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10.1038/s41467-018-07290-y | Medicine_easy_503 | For further information, please contact the cited source. | This sensing-and-protrusion matrix facilitates high spatial segregation of adhesion ligands but retains biomechanical coupling between the two systems 48 . | Within a few years, the researchers hope to move to clinical trials in humans. Note: material may have been edited for length and content. For further information, please contact the cited source. | Combined, this suggests a model where a wellestablished multitude of interactions between MTs and contracting peripheral F-actin stress-fibers (via conventionally known MT-actomyosin interactions adaptors, such as myosin, and TIP 50 and septin 49 complex, which can be overexpressed in some carcinoma cells 52 ) are necessary to promote Arp2/3-dependent uniaxial dimensionality commitment on biaxial contact guidance cues (Fig. This sensing-and-protrusion matrix facilitates high spatial segregation of adhesion ligands but retains biomechanical coupling between the two systems 48 . We confirmed the specificity of the collagen and E-cadherin ligands through immunofluorescence staining, where no cross-reactivity was observed (Supplementary Figure 9) . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37755115692&p=1pl&v=1&x=-Mn9Lv5PBlXV6JRvBL7A3Q |
10.1186/1750-1326-10-2 | Medicine_easy_504 | In this field studying sAPP and its fragments could be extremely useful. | In the absence of capture-antibody (IPc), or when a rabbit IgG was used for immunoprecipitation (not shown), no bands were observed on the immunoblots ( Figure 1C, D) . | Professor Saez Valero, along with Inmaculada Cuchillo and Inmaculada Lopez, main authors of the study, explain that this finding opens the possibility of designing new tests applicable in the early diagnosis and clinical trials, in order to effectively estimate the value of sAPP as a biomarker for Alzheimer's. The validation of new biomarkers for clinical diagnosis of Alzheimer's disease in its early stages is a priority for the appropriate therapeutic intervention of disease. In this field studying sAPP and its fragments could be extremely useful. | We do not exclude that some of the 6E10 immunoreactivity detected in Sigma-Ct immunoprecipitates arises from sAPPα forms, reflecting the presence of heteromers containing sAPPf and sAPPα. In the absence of capture-antibody (IPc), or when a rabbit IgG was used for immunoprecipitation (not shown), no bands were observed on the immunoblots ( Figure 1C, D) . The major APP band in the brain was identified at~240 kDa with the 6E10 antibody. | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2015/02/150204075222.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news%2Ftop_health+%28ScienceDaily%3A+Top+Health+News%29 |
10.1016/j.cub.2018.03.039 | Medicine_easy_505 | As moscas macho procuram um par para acasalar atraves de melodias criadas pelas vibracoes de suas asas para atrair femeas e entao poderem ejacular. | None of the genotypes showed a significant preference for the activation zone when both sides of the arena were un-illuminated ( Figure 1C) . | Outra maneira eficiente de diferencia-las e atraves do comprimento do seu corpo, se a mosca e curta e de cauda redonda, entao e macho. As moscas macho procuram um par para acasalar atraves de melodias criadas pelas vibracoes de suas asas para atrair femeas e entao poderem ejacular. A investigacao continuou quando puseram as moscas modificadas em um quarto com iluminacao vermelha, onde notaram que os insetos preferiam ficar debaixo da luz, ja que ela causava uma ejaculacao. | For example, in a two-choice preference assay, flies prefer to reside in a zone where they receive optogenetic stimulation of reward-encoding neurons . None of the genotypes showed a significant preference for the activation zone when both sides of the arena were un-illuminated ( Figure 1C) . CRZ > CsChrimson males, but not genetic controls, showed a strong positional preference for the illuminated zone during the two-choice phase ( Figures 1D and 1E ). | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34574646081&p=1pl&v=1&x=SvgIniugq6r2rX-R8WD__A |
10.1073/pnas.1703200114 | Medicine_easy_507 | Instead, they simply need to wash the slide in a buffer solution to remove any extraneous particles. | In both cases, as expected the data show good correspondence with ELISA values (dashed black trace). | Using the D4 assay, researchers don't need to follow a complicated workflow to clear non-target proteins from their slide, as with the ELISA test. Instead, they simply need to wash the slide in a buffer solution to remove any extraneous particles. Leptin levels are typically measured using ELISA, but the researchers recognized that if they could use the D4 assay to accurately test for leptin levels, the tool could be used to plan better treatment for those suffering from malnutrition in resource-limited settings. | In this experiment, the scanner was more sensitive than the mobile phone, with LODs determined to be 0.037 ng/mL and 0.71 ng/mL, respectively. In both cases, as expected the data show good correspondence with ELISA values (dashed black trace). Transitioning to the mobile phone-based detection platform reduced detection sensitivity and interassay consistency, as seen by the higher LOD and larger error bars with the mobile phone device. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/printable-tool-enables-sensitive-diagnostic-testing/ |
10.1016/j.canlet.2014.04.014 | Medicine_easy_508 | Unfortunately, four years after Dr. Warburg gave this statement, he died. | Intriguingly, OGA is a bifunctional enzyme harboring O-GlcNAc cleavage activity as well as HAT activity, implying an intrinsic relationship between histone O-GlcNAcylation and acetylation. | From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Unfortunately, four years after Dr. Warburg gave this statement, he died. It's not something that is openly publicized, it seems. | Additionally, H2B monoubiquitination facilitates H3K4 and H3K79 methylation . Intriguingly, OGA is a bifunctional enzyme harboring O-GlcNAc cleavage activity as well as HAT activity, implying an intrinsic relationship between histone O-GlcNAcylation and acetylation. Sakabe and Hart reported that both OGT catalytic activity and O-GlcNAc levels on histones (particularly H3) are reduced during early mitosis and are gradually increased during late mitosis to G1 phase . | [1] | Medicine | train | 1 | news | http://www.inquisitr.com/1834216/two-cancer-doctors-were-possibly-silenced-about-its-main-causes-see-why-they-say-the-disease-forms/ |
10.1001/jama.299.24.2884 | Medicine_easy_510 | During the transition period there were some challenges for physicians and secretaries. | The same limitation of studies on EMI by mobile phones, generalization of demonstrated EMI incidents, applies to the present study on RFID. | This allowed doctors and secretaries to make all the necessary adjustments and distribute documentation quickly enough to meet treatment guidelines. During the transition period there were some challenges for physicians and secretaries. Despite this, even the initial speech recognition results were very high - as high as 97% and 100%. | The 30-cm median distance for all incidents found with RFID might be more critical compared with the median range of 3 cm with modern mobile phones. The same limitation of studies on EMI by mobile phones, generalization of demonstrated EMI incidents, applies to the present study on RFID. Our results apply only on the technology of 1 active and 1 passive RFID system from 2 specified manufacturers. | [1] | Medicine | train | 1 | news | http://www.bio-medicine.org/medicine-news-1/The-Oscar-Lambret-Center--28France-29-Completes-First-Stage-Of-Winscribe-Text-Rollout-147489-1/ |
10.1038/s41379-019-0249-1 | Medicine_easy_511 | Note: material may have been edited for length and content. | HPV-negative tumors were more frequently of the non-squamous type (9/21, 43% vs. 37/193, 19%; p < 0.01) and showed negative p16 staining (9/21; 43% vs. 7/193; 4%; p < 0.01). | "The new study confirms that HPV-negative tumours represent a more aggressive type of cancer with worse prognosis, which must be considered for the clinical management of these patients," he adds. Note: material may have been edited for length and content. For further information, please contact the cited source. | Twenty-one out of 214 tumors (10%) were negative for HPV DNA. HPV-negative tumors were more frequently of the non-squamous type (9/21, 43% vs. 37/193, 19%; p < 0.01) and showed negative p16 staining (9/21; 43% vs. 7/193; 4%; p < 0.01). HPV-negative tumors were more frequently diagnosed at advanced FIGO stage (19/21, 91% vs. 110/193, 57%; p < 0.01) and more frequently had lymph node metastases (14/21, 67% vs. 69/193, 36%; p < 0.01). | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39016732778&p=1pl&v=1&x=cbOsRpZYCVu8RgjbTeOnHg |
10.1016/j.neuron.2017.09.032 | Medicine_easy_513 | "We might find a way to stimulate the human brain or optimize training techniques to mitigate those deficits." | In Figure 7A , we found that theta synchrony dropped both early (LM1, b = À0.28891, p = 0.027735, two-sided t test) and late (LM1, b = À0.27005, p = 0.015615). | "We might find a way to stimulate the human brain or optimize training techniques to mitigate those deficits." The neural signatures could help identify changes in learning strategies that occur in diseases such as Alzheimer's, with an eye to diagnosing these diseases earlier or enhancing certain types of learning to help patients cope with the disorder, says Roman F. Loonis, a graduate student in the Miller Lab and first author of the paper. Molaison couldn't remember eating breakfast a few minutes after the meal, but he was able to learn and retain motor skills that he learned, such as tracing objects like a five-pointed star in a mirror. | This was the case. In Figure 7A , we found that theta synchrony dropped both early (LM1, b = À0.28891, p = 0.027735, two-sided t test) and late (LM1, b = À0.27005, p = 0.015615). In other words, we did not see any difference in the change in theta synchrony before and after learning, like we did for alpha-2/beta-1. | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/w-hfqFowFj8/ |
10.1001/jamacardio.2018.2866 | Medicine_easy_515 | Akcea plans to use the upfront payment to settle a $125 million obligation to Ionis in Akcea common stock, the companies said. | the triglyceride-lowering allele for LPL variants or the LDL-C lowering allele for the 58 LDL-C associated variants) for the effect on the respective lipid trait expressed in standardised units. | "We believe that our deep expertise in cardiovascular and metabolic diseases will help allow this program to reach its maximum potential for patients." Akcea plans to use the upfront payment to settle a $125 million obligation to Ionis in Akcea common stock, the companies said. Before regulatory filing for marketing approval, Akcea has the option to participate in commercialization activities with Pfizer in the United States and certain additional markets on predefined terms and based on meeting predefined criteria. | All genetic variants satisfied these criteria: (1) were over 500 kb away from each other and had no or negligible linkage disequilibrium (R 2 < 0.01); (2) the genetic regions were associated with LDL-C levels (p < 5 x 10 -8 ) in the Global Lipids Genetics Consortium analysis of up to 188,577 individuals. the triglyceride-lowering allele for LPL variants or the LDL-C lowering allele for the 58 LDL-C associated variants) for the effect on the respective lipid trait expressed in standardised units. Because polymorphisms included in genetic scores are inherited approximately randomly at the time of conception in a process known as "Mendelian randomisation", 18 and inherited approximately independently of the other polymorphisms included in the genetic score, the number of lipid lowering alleles that a person inherits for each genetic score should also be random. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=40368499467&p=1pl&v=1&x=JSZ2HfjDtiFiPnSQRe8oew |
10.1038/s41467-018-04227-3 | Medicine_easy_518 | But the nanospheres also have a natural property that is especially important to Westmeyer's team: They can take in iron atoms and process them in such a way that they remain inside the nanospheres without disrupting the cell's processes. | 5e ). | "We can thus spatially separate processes and give the cells new properties." But the nanospheres also have a natural property that is especially important to Westmeyer's team: They can take in iron atoms and process them in such a way that they remain inside the nanospheres without disrupting the cell's processes. The iron-incorporating nanocompartments are helping us to take a big step towards this goal," explains Westmeyer. | 5d ) indicating that in the absence of the nancompartment the imported iron was not sufficiently sequestered by the endogenous iron homeostasis machinery. 5e ). These data confirmed that either B or C are sufficient to load the nanocompartment with iron and showed that no obvious additional iron loading resulted from the presence of the Mms peptides. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34116477623&p=1pl&v=1&x=15ixZ62UWCQkoigx-xwN7Q |
10.1126/science.1261447 | Medicine_easy_521 | "The resources we've generated will allow us and others to delve even deeper, and finally begin to really understand the workings of this invisible world." | At larger scales ( Fig. | "The finding that temperature shapes which species are present, for instance, is especially relevant in the context of climate change, but to some extent this is just the beginning," says Chris Bowler, a plant biologist from the French National Centre for Scientific Research. "The resources we've generated will allow us and others to delve even deeper, and finally begin to really understand the workings of this invisible world." They found a large spike in the nitrite levels of younger rings, but had no clue as to its cause. | The mixed layer of the young ring was deep (>250 m) compared with seasonal cycles of the mixed layer depths in the region (50 to 100 m) (Fig. At larger scales ( Fig. 4B ) ( , steep spatial gradients were observed, with fresher and colder water in the Cape Basin than in the Agulhas Current because of both lateral mixing with waters from the south and surface fluxes. | [1] | Medicine | train | 1 | news | http://newsoffice.mit.edu/2015/uncovering-diverse-invisible-ocean-world-0526 |
10.1007/s10803-016-2729-1 | Medicine_easy_522 | Worth nearly PS300,000, her project will run up until 2018. | Further, 47% of police reported that they were 'fairly knowledgeable' about ASD. | The new funding will enable her to expand her research into developing support for the challenges people with autism spectrum disorder face in other important real life contexts, in particular for job interviews and medical consultations. Worth nearly PS300,000, her project will run up until 2018. Commenting on the funding, she said: "I'm thrilled to receive this award. | More specifically, police respondents were largely satisfied (42%) with their dealings with the ASD community; with only 21% reporting dissatisfaction (37% gave a neutral response). Further, 47% of police reported that they were 'fairly knowledgeable' about ASD. However, the possibility of a discrepancy between police self-reported competence and professional conduct in practice cannot be discounted. | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/xSk6tvoBtH4/ |
10.1098/rsif.2013.1205 | Medicine_easy_523 | As a result of this lateral friction contact, larger dirt particles are removed. | 30 g 5 g Owing to the random population and position of the contaminants in each samples, the processes of adhesion recovery for two samples were never alike. | (Photograph with scanning electron microscope: Michael Rohrig, KIT)
When moving forwards, the geckos toes drag across a part of the surface. As a result of this lateral friction contact, larger dirt particles are removed. Smaller particles deposit among the setae on the sole and in the skinfolds below. | Results from the experiments in figures 4 and 5 show significant cleaning for all samples. 30 g 5 g Owing to the random population and position of the contaminants in each samples, the processes of adhesion recovery for two samples were never alike. Nevertheless, we observed a general agreement between the adhesion recovery trend for a given contaminant size regime, depending on the ratio of the particle diameter to the fibre tip diameter. | [1] | Medicine | train | 1 | news | http://www.nanowerk.com/nanotechnology_news/newsid=34447.php |
10.1007/s40675-017-0065-4 | Medicine_easy_525 | "So, definitely a big improvement from four hours," she says. | Indeed, when dCBT was piloted within a UK mental health service based on the stepped care model, 59% of patients showed a reliable recovery, with 88% completing four or more sessions . | "So, definitely a big improvement from four hours," she says. Thesing is not alone. Nearly 100 people wrote back suggesting a range of apps, including podcasts created to put a listener to sleep. | This highlights that integrating dCBT into traditional clinical care might be a slow process in need of innovative approaches and thorough research on integration models, such as the stepped care model. Indeed, when dCBT was piloted within a UK mental health service based on the stepped care model, 59% of patients showed a reliable recovery, with 88% completing four or more sessions . It is important to consider dCBT as part of the whole spectrum of digital medicine, a rapidly developing, new field of medicine, where technologies will revolutionize how patients and health professionals interact. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37327604103&p=1pl&v=1&x=T1rdR-YWJ5homnguLqVtLg |
10.1016/j.molcel.2014.02.019 | Medicine_easy_528 | "Importantly, this work shows that silent locus identity is required for, but separable from, actual gene silencing," Pikaard said. | Two loci shown to be susceptible to such spontaneous losses of CG methylation and silencing are among the Group E loci identified in our study: At5g24240 and At4g14548 (which we call ERT9 and ERT11, respectively). | The discovery made by a 12-member all-Indiana University team of scientists led by IU biologist and biochemist Craig Pikaard provides important new insight into how plant cells know to silence a genetic locus -- that specific place on a chromosome where a gene is located -- in every successive generation. "Importantly, this work shows that silent locus identity is required for, but separable from, actual gene silencing," Pikaard said. "We've found that epigenetic inheritance is a two-step process, with the heritable specification of silent locus identity occurring before actual silencing of the locus can occur." | However, spontaneous loss of CG methylation occurs at individual loci, resulting in the sporadic emergence of transcriptionally active epialleles Schmitz and Ecker, 2012; Schmitz et al., 2011) . Two loci shown to be susceptible to such spontaneous losses of CG methylation and silencing are among the Group E loci identified in our study: At5g24240 and At4g14548 (which we call ERT9 and ERT11, respectively). Sporadic erasure of HDA6-and MET1-dependent silent locus identity can presumably account for the emergence of stable, active epialleles at these loci. | [1] | Medicine | train | 1 | news | http://www.newswise.com/articles/gene-silencing-instructions-acquired-through-molecular-memory-tags-on-chromatin |
10.1126/scitranslmed.aan3879 | Medicine_easy_529 | "It may even have potential for temporarily treating gunshot wounds." | These formed shapes were also maintained at 10°C, below LCST, resulting in complete structural collapse after a few hours, consistent with the thermoresponsive trends observed (fig. | "First responders at a mass casualty incident could deploy the hydrogel while patients wait for their injuries to be completely repaired by an ocular surgeon in appropriate microsurgical facilities," Whalen noted. "It could also be useful in emergency rooms in rural areas where there isn't an eye center with such capabilities nearby," he added. "It may even have potential for temporarily treating gunshot wounds." | Shape persistence and stability remained for 1 month in an aqueous environment above its LCST (Fig. These formed shapes were also maintained at 10°C, below LCST, resulting in complete structural collapse after a few hours, consistent with the thermoresponsive trends observed (fig. Our hydrogel challenges the preconception that materials held together by noncovalent forces and mostly composed of water are weak. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=32701646499&p=1pl&v=1&x=eK9q0MrjpuJALT5vetSZOg |
10.1038/s41598-018-37709-x | Medicine_easy_530 | People with cognitive impairment had fewer capillaries in their retina than those who did not. | The AI platform will allow for accurate classification of participants into cognitively healthy or cognitively impaired by comparing their CGN_ICA test profile with a large dataset of many individuals with validated clinical status which the AI platform has "learned" from. | Weintraub thinks that lower capillary counts could help indicate the early signs of dementia. People with cognitive impairment had fewer capillaries in their retina than those who did not. That's not enough data to predict if a person is in the early stages of dementia. | The CGN_ICA is designed to be an extremely easy to use, versatile and practical measurement tool for studies into dementias and other conditions that have an element of cognitive function, as it allows simple, sensitive and repeatable data collection of an overall score of a subject's cognitive ability. The AI platform will allow for accurate classification of participants into cognitively healthy or cognitively impaired by comparing their CGN_ICA test profile with a large dataset of many individuals with validated clinical status which the AI platform has "learned" from. The AI engine will have the ability to improve its accuracy over time by learning from new data points that are incorporated into its training datasets. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39669460552&p=1pl&v=1&x=_5nPswP0wchea4m11hUqkQ |
10.1097/01.psy.0000170341.88395.47 | Medicine_easy_532 | In some cases, even if the tears appear to have healed, they may have left nerve damage, according to Prendergast, as nerves grow slowly and may be "stunned" after birth. | In healthy subjects, our own research group has reported lower mean 24-hour ABP in men and women reporting high compared with intermediate or low relationship quality and those with no partnered relationship . | The effects of childbirth vary depending on what kind of labor your partner had. In some cases, even if the tears appear to have healed, they may have left nerve damage, according to Prendergast, as nerves grow slowly and may be "stunned" after birth. If your partner did experience tearing during labor, she might feel self-conscious about the way her vagina looks. | The quality of the marital relationship seems to play an essential role in health outcomes , with greater levels of marital dissatisfaction and discord linked to enhanced health risk . In healthy subjects, our own research group has reported lower mean 24-hour ABP in men and women reporting high compared with intermediate or low relationship quality and those with no partnered relationship . In another study of ABP at home and work, time spent with the spouse or partner was characterized by lower BP compared with times spent with others or alone . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33626619506&p=1pl&v=1&x=OTigSvsWVsrww9rX18b9rw |
10.1002/nau.23116 | Medicine_easy_533 | "Women experienced that the app was suitable for this kind of [pelvic floor] training since they carried their smartphones with them at all times, and the reminders helped and motivated them to perform their training regularly," Asklund explained. | The overall scores can be divided into severity categories (1-5 = slight, 6-12 = moderate, 13- = severe, 19-21 = very severe). | "Two thirds of the women using the app were satisfied with the treatment outcomes," lead author Ina Asklund, PhD, told Health in an email. "Women experienced that the app was suitable for this kind of [pelvic floor] training since they carried their smartphones with them at all times, and the reminders helped and motivated them to perform their training regularly," Asklund explained. For women who'd prefer to manage their incontinence themselves, this is an option worth trying, she says: "There are many health apps, but very few are evaluated in research studies." | The responses summed to an overall score of 0-21, where 21 was most severe. The overall scores can be divided into severity categories (1-5 = slight, 6-12 = moderate, 13- = severe, 19-21 = very severe). The ICIQ-LUTSqol contained 19 questions that summed to an overall score of 19-76, where 76 corresponded to the highest impact on quality of life. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/this-app-might-help-treat-your-incontinence-study-says/ |
10.1038/s41598-017-14953-1 | Medicine_easy_535 | Ultimately, reducing the transfer of antibiotic-resistance plasmids could help preserve the potency of antibiotics, contributing to an overall strategy to help improve human health, he added. | 5, ). | Such molecules could one day be applied in clinics in hospitals that are hotbeds of resistance, Baron hopes. Ultimately, reducing the transfer of antibiotic-resistance plasmids could help preserve the potency of antibiotics, contributing to an overall strategy to help improve human health, he added. "The beauty of what we are working on here is that the proteins are very similar to proteins that bacteria use to cause disease. | The molecules do not negatively impact bacterial viability and they have no effect on transfer of the unrelated plasmid RP4, suggesting that the effect is specific for pKM101 (supplementary Fig. 5, ). The DSF approach used as primary assay to screen a library of several hundred fragments can be conducted in most molecular biology laboratories since it uses a commonly available RT-PCR instrument and does not necessitate specialized high-throughput screening equipment. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/antibiotics-resistance-researchers-succeed-to-block-genes-of-resistance/ |
10.1073/pnas.1719666115 | Medicine_easy_537 | And males who cooperated well with other males may have been more successful hunters and scavengers. | Their intake of relatively rare, high-protein/ fat foods would have substantially increased depending on the skills of their "provisioner(s)." | The combination "is a key difference that sets apart humans from all other species," Raghanti says. And males who cooperated well with other males may have been more successful hunters and scavengers. As human ancestors got better at cooperating, they shared the know-how for making tools and eventually developed language--all in a feedback loop fueled by surging levels of dopamine. | Their own search time and travel would have been substantially reduced, allowing them to intensify infant care and to more successfully avoid predators. Their intake of relatively rare, high-protein/ fat foods would have substantially increased depending on the skills of their "provisioner(s)." Females' choice of males with the greatest environmental awareness would be under intense selection, as would a male's capacity to carry exceptionally valuable foods for significant distances. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33063269549&p=1pl&v=1&x=GY_Ozg3nrmLLkOMikJx2og |
10.1080/10408398.2016.1247252 | Medicine_easy_538 | aIt doesnat seem to be something we should be overly concerned with,a she says. | In adults, coffee and tea were the biggest contributors to total caffeine intake. | It gives employees the choice to deny the sale of caffeinated beverages to anyone under the age of 16. aIt doesnat seem to be something we should be overly concerned with,a she says. The numbers vary, but they can be taken to suggest that caffeine, in moderation, is nothing to worry about. | Caffeinated soft drinks (48.9%) and tea (38.0%) were the greatest contributors to total caffeine intake in children and adolescents, whereas coffee (5.4%), and energy drinks (0.6%) only had a small contribution to daily total caffeine intake. In adults, coffee and tea were the biggest contributors to total caffeine intake. In adults, total caffeine intake ranged from 122 to 143 mg/day. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37606354782&p=1pl&v=1&x=NkCPm4nvG7M0zaIIZkj4mw |
10.1177/0956797615617897 | Medicine_easy_539 | And the analysis of the infantsaEUR(tm) behaviour shows that when they expected a liquid they were surprised to see it blocked by the grid (or see the grid unable to penetrate the material). | 44, 16 .59]. | aEURoeIf infants understand the properties of liquids, then they should be surprised when, what they think is a liquid gets trapped on a gridaEUR. And the analysis of the infantsaEUR(tm) behaviour shows that when they expected a liquid they were surprised to see it blocked by the grid (or see the grid unable to penetrate the material). Conversely, if they thought they were looking at a solid, then they were surprised when they saw it pass through the grid. | Infants who were habituated to the liquid looked an average of 6.45 s (SD = 8.56), 95% CI = [3.42, 9.49] longer at the novel events than at the familiar events, whereas infants habituated to the solid looked an average of 12.51 s (SD = 10.71) longer at the novel events than at the familiar events, 95% CI = [8. 44, 16 .59]. Although we did not predict this effect, infants may have firmer expectations about a solid's behavior than about a liquid's behavior, and thus the infants in our experiment may have been more surprised by the solidto-liquid shift than by the reverse shift. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/babies-have-a-grasp-of-the-physics-of-liquids/ |
10.1890/14-0684.1 | Medicine_easy_540 | "Lemurs fill an important role as the gardeners for these trees. | Total area sampled per site was 18 000 m 2 . | "Seeds away from the parent tree survive better because there's less competition among seedlings," Razafindratsima said. "Lemurs fill an important role as the gardeners for these trees. By ensuring that some seeds land in spots suitable for germination and survival, they increase the ability of these trees to replace themselves"
Dunham hopes the study will contribute to growing efforts to protect lemurs, and therefore the rainforest, which has been impacted in recent years by economic and political instability. | The gap category was representative of observed recent tree-fall gaps in the park. Total area sampled per site was 18 000 m 2 . However, our germination rates for Cryptocarya seeds were similar to rates found for seeds passed through the gut of the three lemur species in a previous study . | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2014/11/141104083849.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1038/srep33746 | Medicine_easy_542 | That requires further work, but it is an exciting and important possibility." | As seen previously (Fig. | "Through this process we were able to demonstrate how the spread of this toxicity is driven. In doing that we also uncovered a previously unknown, fast acting, neuroprotective signalling mechanism. That requires further work, but it is an exciting and important possibility." | Spreading toxicity during stroke or a TBI in vivo is likely to be a consequence of both synaptic toxicity through hyperactivity and excitotoxicity from extracellular accumulation of glutamate 5 . As seen previously (Fig. 3a,c) , no protection was afforded to the directly preconditioned chamber (Fig. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/stimulating-neurons-could-protect-against-brain-damage-research-shows/ |
10.1098/rsos.150292 | Medicine_easy_543 | Sheas stressed and desperate, so itas a relief when they FaceTime her asking her to acome playa while calling her aBeckalicious.a When she asks, aYou guys love me?a they respond like thatas the dumbest question in the world. | The 15-layer has likewise been widely identified, with online values varying between 11.2 and 20.9 and offline between 9.0 and 20.0 . | Lifetime
The audienceas first introduction to Beck's friends Peach, Annika, and Lynn paints them as a good support system for our weary protagonist. Sheas stressed and desperate, so itas a relief when they FaceTime her asking her to acome playa while calling her aBeckalicious.a When she asks, aYou guys love me?a they respond like thatas the dumbest question in the world. aOf coursea they love her. | Sample 1 also confirms the existence and size of the two innermost layers of the social network, now conventionally identified as the support clique and the sympathy group . The 15-layer has likewise been widely identified, with online values varying between 11.2 and 20.9 and offline between 9.0 and 20.0 . In the present sample, the mean values for these two layers (4.1 and 13.6) fit comfortably within these ranges. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38341050496&p=1pl&v=1&x=Q_UDVvb8Z9mwJ-bM3otzgg |
10.1073/pnas.1313039111 | Medicine_easy_544 | Lee said the players found a solution by putting the GC pairs only at the end of the stack -- "capping" -- and filling the rest of the stack with adenine-uracil pairs. | These results show that an online community can carry out large-scale experiments, hypothesis generation, and algorithm design to create practical advances in empirical science. | But too many GC pairs can produce some unexpected shapes when synthesized -- "It's like doing origami with a cardboard box," as one player put it. Lee said the players found a solution by putting the GC pairs only at the end of the stack -- "capping" -- and filling the rest of the stack with adenine-uracil pairs. They also are developing a template that researchers in other fields can use to turn scientific projects into online challenges. | These rules, distilled by machine learning into a new automated algorithm EteRNABot, also significantly outperform prior algorithms in a gauntlet of independent tests. These results show that an online community can carry out large-scale experiments, hypothesis generation, and algorithm design to create practical advances in empirical science. The initial 6-mo training period, called phase I, saw the EteRNA community engaging in six RNA design problems containing increasing numbers of nonhelical elements (bulges and multihelix junctions) and more complex topologies ( Fig. | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2014/01/140127164801.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1002/per.704 | Medicine_easy_545 | However, that impulse toward convention doesn't lend itself to every job type. | A total of 731 participants met these criteria: 181 participants from the baseline assessment only, 248 participants from the follow-up assessment only, and 302 from both assessments. | While conscientiousness doesn't correlate with high SAT scores, it does predict high GPAs. However, that impulse toward convention doesn't lend itself to every job type. Work that requires innovation, creativity, and spontaneity doesn't fit well to a highly conscientious personality; a highly conscientious painter would stick to the norms of a genre rather than expanding it, and a highly conscientious chef would be less likely to tinker with tried-and-true recipes. | Finally, as young adulthood is more of a time of flux, in both personality and work life, and therefore more susceptible to outside influences, we expect the longitudinal relations to be confined primarily to younger adults. A total of 731 participants met these criteria: 181 participants from the baseline assessment only, 248 participants from the follow-up assessment only, and 302 from both assessments. Income and job satisfaction were available for a subset of these participants (income: concurrent n = 631, longitudinal n = 242; job satisfaction: concurrent n = 719, longitudinal n = 302; prestige scores were available for all participants). | [1] | Medicine | train | 1 | news | http://www.businessinsider.com/conscientiousness-predicts-job-performance-2014-12 |
10.1038/s41540-017-0043-y | Medicine_easy_546 | "Synthetic biology is important for gene therapy applications, and our methodology may assist in building more robust and reliable therapeutics in the future," Bleris said. | Using Pearson's correlation, the coefficient of determination (R-Squared) values obtained from the fits for the 1, 0.1, and 0.01 ng/mL Dox concentrations were all above 0.95 where the 0.001 ng/mL Dox induced group had an R-Squared value above 0.8. | "By using principles of math and physics in synthetic biology, we uncovered specific properties of microRNA that can be used in future applications for targeted and smart therapeutics." He also said that this research could shed light on natural genetic redundancies and other diseases where microRNA are not at physiological levels. "Synthetic biology is important for gene therapy applications, and our methodology may assist in building more robust and reliable therapeutics in the future," Bleris said. | where γ is the decay constant, ω controls the rate of saturation with respect to c, which represents the plasmid copies. Using Pearson's correlation, the coefficient of determination (R-Squared) values obtained from the fits for the 1, 0.1, and 0.01 ng/mL Dox concentrations were all above 0.95 where the 0.001 ng/mL Dox induced group had an R-Squared value above 0.8. Interestingly, the decay constant γ was found to be the same at all Dox concentrations, thus attributing the differences in behavior of the repression efficiency at different Dox concentrations to variations in the parameter ω. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33490142809&p=1pl&v=1&x=7kV89J9ospqm2Qxx1MsxLg |
10.1186/s12929-018-0404-x | Medicine_easy_547 | Dr. Schneider says that regular activity doesnat necessarily mean you have to start hitting the gym every day. | In aged rats and primates, BDNF infusion produced beneficial effects on age-related perturbations in gene expression and ameliorated agerelated cognitive impairment . | By cutting down on smoking, you could be doing your a huge favor for your cognitive health down the road. Dr. Schneider says that regular activity doesnat necessarily mean you have to start hitting the gym every day. He said you should aim for a least a few walks a week, and try to keep up an active lifestyle in general. | Reduced protein and mRNA levels of BDNF were found in the hippocampus of postmortem AD samples and MCI patients, . In aged rats and primates, BDNF infusion produced beneficial effects on age-related perturbations in gene expression and ameliorated agerelated cognitive impairment . Indeed, the results showed that APP/PS1 mice performed better in memory tasks if their companies interacted with them more often. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39395405146&p=1pl&v=1&x=jVK2N5h6x8DoIkfbCSzsUA |
10.1073/pnas.1720487115 | Medicine_easy_548 | Those mutational differences often emerged even among closely related species residing on the same plateau, the study reported. | Evolutionary increases in Hb-O 2 affinity may be caused by amino acid mutations that increase the intrinsic O 2 affinity of the Hb tetramer and/or mutations that suppress the sensitivity of Hb to the affinity-reducing effects of allosteric cofactors (nonheme ligands such as Cl − ions and organic phosphates) . | Those mutational differences often emerged even among closely related species residing on the same plateau, the study reported. "You could imagine, just because of the different ancestral starting points, that the Tibetan birds maybe all went one (mutational) route, and the Andean birds typically did things a different way," said co-author Jay Storz, Susan J. Rosowski Professor of Biological Sciences at Nebraska. "But that's not what we saw. | Under severe hypoxia, an increased Hb-O 2 affinity safeguards arterial O 2 saturation, thereby securing tissue oxygenation, albeit at a lower pressure gradient for O 2 diffusion from the peripheral capillaries to the cells of respiring tissues . Evolutionary increases in Hb-O 2 affinity may be caused by amino acid mutations that increase the intrinsic O 2 affinity of the Hb tetramer and/or mutations that suppress the sensitivity of Hb to the affinity-reducing effects of allosteric cofactors (nonheme ligands such as Cl − ions and organic phosphates) . If such contingencies influence the adaptive evolution of Hb function, such that highland representatives of different lineages hit upon different solutions to the same problem, this may be reflected in clade-specific or regionspecific patterns of molecular parallelism. | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/0IiwEKtJQjU/ |
10.1016/j.biopsych.2013.05.025 | Medicine_easy_549 | "The stranger anxiety or wariness that young children typically show is a sign that they understand their parents are very special people who are their source of security." | e n ¼ 2 missing data from PI group. | "The stranger anxiety or wariness that young children typically show is a sign that they understand their parents are very special people who are their source of security." The UCLA researchers discovered that while the typically-raised children exhibited higher amygdala signals for their mothers compared to strangers, the previously institutionalized children showed amygdala responses to strangers that were similar to those they showed toward their adoptive mothers. Additionally, the children who had lived in an institution showed greater amygdala reactivity to strangers than did the typically-raised children. | d n ¼ 8 missing data from Comp group. e n ¼ 2 missing data from PI group. f n ¼ 1 missing data from PI group. | [1] | Medicine | train | 1 | news | http://www.medicaldaily.com/neglected-babies-may-develop-dangerous-indiscriminate-friendliness-childhood-along-changes-brain |
10.1186/gb-2014-15-2-r27 | Medicine_easy_550 | Charles Wondji said: 'We found a population of mosquitoes fully resistant to DDT (no mortality when they were treated with DDT) but also to pyrethroids. | Peaks were detected at 232 nm. | The authors say that knowing how resistance works will help to develop tests, and stop these genes from spreading amongst mosquito populations. Charles Wondji said: 'We found a population of mosquitoes fully resistant to DDT (no mortality when they were treated with DDT) but also to pyrethroids. They identified the GSTe2 gene as being upregulated - producing a lot of protein - in Benin mosquitoes. | All constructs yielded 26.8 kDa products. Peaks were detected at 232 nm. Preliminary crystallization conditions led to crystal clusters of thin plates. | [1] | Medicine | train | 1 | news | http://www.healthcanal.com/infections/47991-researchers-at-lstm-crack-the-genetic-secret-of-mosquito-resistance-to-ddt-and-bed-net-insecticides.html |
10.1242/jeb.098301 | Medicine_easy_551 | Surprisingly, female ants are the ones who demonstrate this macho behavior. | Negative control (without reverse transcriptase) and melting curve analyses confirmed that the qRT-PCR analysis was not confounded by DNA contamination or primer dimers. | Surprisingly, female ants are the ones who demonstrate this macho behavior. "The answer appears to be dopamine. We found that gamergates have dopamine levels two to three times higher than other workers." | Pooling brain samples within colonies was necessary to get measurable levels of biogenic amines but it does decrease resolution with respect to individual brain amine levels. Negative control (without reverse transcriptase) and melting curve analyses confirmed that the qRT-PCR analysis was not confounded by DNA contamination or primer dimers. We included gamergates from seven additional colonies in this study (20 colonies total), and with this larger sample size all variables conformed to the assumption of normality required for regression analyses. | [1] | Medicine | train | 1 | news | http://www.natureworldnews.com/articles/7008/20140512/dopamine-turns-worker-ants-into-warrior-queens.htm |
10.1186/s12915-018-0524-5 | Medicine_easy_552 | "It's not unlike seeing a bicycle being pedaled: You get more than a static picture and a better understanding of how it works. | It appears, however, that at the very high concentrations of CEF applied here (around 200 mmol/L), stacking is not required for effective catalysis, as the kinetics in the monomeric needles, where stacking does not occur, is similar to that in the shard crystal form. | "This will teach us more about how nature has selected for and designed these molecules to work," he said. "It's not unlike seeing a bicycle being pedaled: You get more than a static picture and a better understanding of how it works. "Anytime you want to engineer a protein or recreate a molecular machine, knowing more about how they work at a fundamental level is going to be helpful, whether it's breaking down cellulose for biofuels or designing a new drug or improving an existing drug." | However, the binding of the additional CEF molecule could be a mechanism to steer the substrate towards, and orient it with respect to, the active site under certain conditions. It appears, however, that at the very high concentrations of CEF applied here (around 200 mmol/L), stacking is not required for effective catalysis, as the kinetics in the monomeric needles, where stacking does not occur, is similar to that in the shard crystal form. When only low CEF concentrations are present, stacking might well be essential to recruit antibiotic substrate molecules to promote effective BlaC function. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34227031048&p=1pl&v=1&x=lbeh9QknwsyjFW3nEb3T4Q |
10.1111/j.1749-6632.2012.06538.x | Medicine_easy_553 | His 2 Week Diet also:
lCorrects common misconceptions popularized by the mainstream dieting industry
lProvides dieters with a straightforward, step-by-step plan of action
Produces rapid results to fuel dieter motivation avoids outdated and ineffective techniques like "Count every calorie" and the "Eat less, exercise more" mantra. | Only 4% (4/97) of controls had zonulin levels 2 SD above the mean (P < 0.01). | SOURCE: Dr. Fasano Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384703/
"If we take control of cellular inflammation, we can effectively increase our ability to lose weight, burn fat, increase metabolism, and permanently stave off body fat," Flatt said. His 2 Week Diet also:
lCorrects common misconceptions popularized by the mainstream dieting industry
lProvides dieters with a straightforward, step-by-step plan of action
Produces rapid results to fuel dieter motivation avoids outdated and ineffective techniques like "Count every calorie" and the "Eat less, exercise more" mantra. "It's true that eating certain foods and following rigorous workout programs will produce weight loss. | Forty-two percent (141/339) of T1D patients and 29% of their first-degree relatives (26/89) had serum zonulin levels that were 2 SD above the mean zonulin levels detected in age-matched healthy controls. Only 4% (4/97) of controls had zonulin levels 2 SD above the mean (P < 0.01). Serum zonulin was higher in T1D as compared to their relatives (P = 0.01). | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33868436087&p=1pl&v=1&x=DGr_SOV1N3U402PHXaTl9Q |
10.1186/s40168-016-0167-0 | Medicine_easy_554 | "As a young scholar at the beginning of my career, I am privileged to work with a scientist who is open-minded to new ideas and has an unquenchable passion for his work." | We conclude that it is critical to compare the microbiome of habitat without human occupation to habitat with human occupation since humans appeared to be the primary source of contamination in such habitats. | "The biggest assets for my career, to be where I am right now, are my students and postdocs," he said. "Dr. Venkat showed me and other members of our group that teamwork and collaboration are very crucial while doing research," said Aleksandra Checinska, a postdoctoral scholar at JPL through Caltech in Pasadena, which manages JPL for NASA. "As a young scholar at the beginning of my career, I am privileged to work with a scientist who is open-minded to new ideas and has an unquenchable passion for his work." | Furthermore, the MARS 500 microbial analysis did not contain control, i.e., preoccupation bacterial diversity measurements, to compare the microbial accumulation as measured in this study. We conclude that it is critical to compare the microbiome of habitat without human occupation to habitat with human occupation since humans appeared to be the primary source of contamination in such habitats. Such a comparison may enable development of cleaning and maintenance protocols. | [1] | Medicine | train | 1 | news | http://www.spacedaily.com/reports/Microbes_in_Space_JPL_Researcher_Explores_Tiny_Life_999.html |
10.1093/sysbio/syx064 | Medicine_easy_557 | the K-Pg event) led to an acceleration in the rate of genetic evolution among its avian survivors. | On the left, the red curve indicates a normal distribution fit to the body size distribution of the LM assemblage. | the K-Pg event) led to an acceleration in the rate of genetic evolution among its avian survivors. These survivors may have been much smaller than their pre-extinction relatives. "All of the new evidence we have reviewed is also consistent with a Lilliput Effect affecting birds across the K-Pg mass extinction." | The depicted progression of body size reduction represents an improvement of up to 36 AICM units relative to a model that constrains the three deepest nodes to the mean LM estimate ( AICM A-B ∼36). On the left, the red curve indicates a normal distribution fit to the body size distribution of the LM assemblage. The latter two models accommodate rapid character evolution near the clade MRCA, followed by a linear or exponential decrease in the rate of evolution. | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/q6b3I3XpwRc/ |
10.1038/s41586-018-0347-0 | Medicine_easy_558 | This is important not only for juicing up smartphones and laptops. | Any Methods, including any statements of data availability and Nature Research reporting summaries, along with any additional references and Source Data files, are available in the online version of the paper at https://doi.org/10.1038/s416-018-0347-0. | This is important not only for juicing up smartphones and laptops. It could help the environment too. You get a lot more unwanted chemical reactions with the electrolyte, so the battery doesn't last as long. | These criteria, which lead to extremely high power and energy densities (Fig. Any Methods, including any statements of data availability and Nature Research reporting summaries, along with any additional references and Source Data files, are available in the online version of the paper at https://doi.org/10.1038/s416-018-0347-0. 1, Supplementary Fig. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34640963107&p=1pl&v=1&x=go9GPx4dYbjzgyOgK56GFA |
10.1038/s41467-018-07425-1 | Medicine_easy_559 | A high level of STING pathway activity was also detected in the lung tissue of patients with pulmonary fibrosis. | 12b ), we could show that silica-induced activation of the STING pathway, including STING dimerization and phosphorylation of TBK1 and IRF3, was partly reduced after knockdown of IFI204 and more importantly after DDX41 knockdown ( Supplementary Fig. | They also demonstrated that treatment with DNase I, an enzyme that degrades the DNA released into the airways, prevents silica-induced lung inflammation. A high level of STING pathway activity was also detected in the lung tissue of patients with pulmonary fibrosis. Thus the mechanism discovered in mice exposed to silica seems to also play a role in humans. | Among DNA sensors activating STING, IFI204, the mouse ortholog of human IFI16, and the helicase DDX41 genes were overexpressed in silica-exposed macrophages (Supplementary Fig. 12b ), we could show that silica-induced activation of the STING pathway, including STING dimerization and phosphorylation of TBK1 and IRF3, was partly reduced after knockdown of IFI204 and more importantly after DDX41 knockdown ( Supplementary Fig. 12c ), as were TNF, CXCL10, and type I IFN expression (Supplementary Fig. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37918696723&p=1pl&v=1&x=7CLKPsENyn8kIUGN0lZgIw |
10.1038/s41586-019-0969-x | Medicine_easy_560 | They were able to study about 80 percent of cells in the earliest embryos and between 3 and 20 percent in the slightly older embryos. | That is, when the nodes are close in (Euclidean) UMAP space, but distant in the graph, they should be linked. | Their analysis didn't capture every single cell in these embryos, but from the researchers' estimates, they got pretty close in some of the developmental stages. They were able to study about 80 percent of cells in the earliest embryos and between 3 and 20 percent in the slightly older embryos. This work is very different from classical methods of studying developmental biology, where researchers would mutate a single gene or a few genes and see what structures changed in the resulting developing animals. | The third major enhancement is that Monocle 3 can learn principal graphs with loops instead of requiring that the trajectory be a tree. That is, when the nodes are close in (Euclidean) UMAP space, but distant in the graph, they should be linked. The principal graph offers users a means of selecting subsets of cells that lead to particular lineages for further analysis. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38634737107&p=1pl&v=1&x=YBRHorf_ThIV1ZkEmYn25A |
10.1038/ijo.2008.130 | Medicine_easy_561 | From the surprisingly long list of nutrients that eggs contain to the extra health benefits that they can provide, there's a lot to love about what eggs can do for you--and how they can help you transform your body. | This lack of intensity is reflected in relatively modest weight loss in 8 weeks in the ED and BD groups. | From the surprisingly long list of nutrients that eggs contain to the extra health benefits that they can provide, there's a lot to love about what eggs can do for you--and how they can help you transform your body. Eggs Provide 'Good' Cholesterol
Chances are, if you've ever spoken to an advocate of decreased egg consumption, you've heard about the dangers of all the cholesterol they contain. The individuals saw their "good" cholesterol (which builds healthy cells and helps the body produce certain hormones) go up after a few weeks of eating multiple eggs a day. | However, eating an egg breakfast while on a reduced energy diet does enhance weight loss. This lack of intensity is reflected in relatively modest weight loss in 8 weeks in the ED and BD groups. Despite the modest weight loss, the results suggest that much better weight loss is possible if the reduction in energy intake, the most common weight loss approach in the United States, is supplemented by an egg breakfast. | [1] | Medicine | train | 1 | news | https://www.theepochtimes.com/what-happens-to-your-body-if-you-eat-2-eggs-a-day-is-it-really-as-bad-as-they-say_2978632.html |
10.1098/rspb.2018.2194 | Medicine_easy_562 | When scientists exposed frogs from quiet ponds to the noises of a busy highway, the amphibians became stressed. | ). | New analysis of frogs from noisy and quiet ponds revealed two different stress and immune profiles. When scientists exposed frogs from quiet ponds to the noises of a busy highway, the amphibians became stressed. In addition to producing more of the stress hormone corticosterone, the frogs also experienced changes to their immune profile. | Additionally, the reduced mass gain over the exposure period may be a response to the cost of maintaining elevated CORT and could impact survival through compromised immune function. ). We provide evidence of the consequences of traffic noise on two fitness-relevant aspects of the innate immune response in a non-human vertebrate. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37757331967&p=1pl&v=1&x=Ic-ANo1XSnsnwmMF4BCyUg |
10.1038/s41564-018-0222-7 | Medicine_easy_563 | The researchers found this same channel through the membrane also serves an unexpected second function, providing a pathway for smaller molecules, such as waste and nutrients, to pass in and out of the parasite. | A full channel conductance (~300 pS) can be estimated from stepwise decrements in conductance (presumably channels diffusing out of the patch, Supplementary Fig. | The researchers found this same channel through the membrane also serves an unexpected second function, providing a pathway for smaller molecules, such as waste and nutrients, to pass in and out of the parasite. Beck said that dual function means this pathway plays an especially critical role for the parasite, making it a potential target for new therapies. "Understanding the structure and function of PTEX can give us clues about how to design new drugs," he said. | 6 ), consistent with sub-conductance states described previously for the PVM when scaling conductance for ion concentration . A full channel conductance (~300 pS) can be estimated from stepwise decrements in conductance (presumably channels diffusing out of the patch, Supplementary Fig. The G-V response was maximal near zero transmembrane potential and diminished with both positive and negative voltages (V half-open, positive = 2 ± 2 mV and V half-open, negative = − 63 ± 2 mV), also consistent with previous reports , . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34929102508&p=1pl&v=1&x=mpGPejlKTQcUHYHeNaqMiA |
10.1038/s41598-017-14471-0 | Medicine_easy_564 | "The biggest gut wrench is that we have starving orcas. | Nevertheless, even when data on certain aspects of the population or its threats are not available, we can use PVA models to explore possible outcomes across a plausible range of values, and thereby identify which factors might be important and the target of additional research. | But with so many other local fish possibilities, it just felt wrong to take chinook out of orcas' mouths, she said. "The biggest gut wrench is that we have starving orcas. That depletes the food supply for orcas in their primary foraging areas.Seeing the impact on the whales, declined to only 75 members in the J, K and L pods, just became too much, Erickson said.She said hers was a decision borne of personal reflection. | PVA can be a powerful tool for informing management and conservation decisions. Nevertheless, even when data on certain aspects of the population or its threats are not available, we can use PVA models to explore possible outcomes across a plausible range of values, and thereby identify which factors might be important and the target of additional research. The Baseline model projects mean population growth over the next 100 years of r = −0.002, with variation across years of SD = 0.045 ( Fig. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34932960007&p=1pl&v=1&x=eDTI_JU64jpqK9Rrut3DpA |
10.1073/pnas.1601040113 | Medicine_easy_566 | This supernova was so close to our planet that, depending on where it went off, our evolutionary ancestors might have seen it as a bright light in the sky. | In particular, surface normalized bacterial Fe-reducing reaction rates are ∼ 1.5 − 2 orders faster for nano-sized ferrihydrite particles as compared to grains with sizes comparable to bulk detrital grains. | This supernova was so close to our planet that, depending on where it went off, our evolutionary ancestors might have seen it as a bright light in the sky. As our solar system traveled through radioactive specks of stardust left over from the explosion, some of the dust broke through our atmosphere and rained down on our planet. That's because the type of ocean crust they found the debris in grows extremely slowly -- about 1 millimeter every million years. | The Fe uptake capability of DMRB from particulate sources depends on the type of source mineral and particle size. In particular, surface normalized bacterial Fe-reducing reaction rates are ∼ 1.5 − 2 orders faster for nano-sized ferrihydrite particles as compared to grains with sizes comparable to bulk detrital grains. MTB are therefore able to take up ferric and ferrous iron from various sources with similar capabilities as for DMRB. | [1] | Medicine | train | 1 | news | http://www.businessinsider.com/stardust-ocean-radioactive-cosmic-supernova-explosion-pnas-2016-8 |
10.1542/peds.2007-1894 | Medicine_easy_567 | Testing this would take around five to seven years and require a sample of several thousand men. | However, a high melanin concentration can cause decreased vitamin D synthesis by preventing UV-B from reaching the stratum basale and spinosum of the epidermis, and this risk becomes manifest in situations of inadequate sun exposure. | For vitamin D to successfully become a biomarker, research would need to prove that the test is safe, consistent, and a provable substitute for clinical endpoint. Testing this would take around five to seven years and require a sample of several thousand men. But lest this research prompts you to go on a sunbathing binge to increase your vitamin D levels, just remember to lather up with sunscreen: Men are more likely to get skin cancer than tumors on their prostate. | Therefore, it imparts an evolutionary advantage to dark-skinned people who live in areas of excessive sun exposure. However, a high melanin concentration can cause decreased vitamin D synthesis by preventing UV-B from reaching the stratum basale and spinosum of the epidermis, and this risk becomes manifest in situations of inadequate sun exposure. It is important to note that women of all populations have lighter skin than men, presumably because of increased vitamin D and calcium needs during pregnancy and lactation. | [1] | Medicine | train | 1 | news | http://qz.com/204932/vitamin-d-may-be-key-to-why-black-men-get-more-deadly-prostate-cancers/ |
10.1038/s41588-018-0127-7 | Medicine_easy_568 | The causes are both genetic and environmental. | 101 ). | This is particularly worrying for severely short-sighted people as it increases their risk of developing eyesight complications. The causes are both genetic and environmental. The study established 161 genetic factors for spherical equivalent and myopia, most of which were previously unknown. | 2b) , and thus weighting by (1/√ n effective ) yielded a final weighting ratio of 1:1 (ref. 101 ). 102 ). | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34316372542&p=1pl&v=1&x=olHMEPNk-t2Lx_dOjLqTiQ |
10.1177/0956797612459659 | Medicine_easy_569 | But itas never too late to begin, right? | In principle, the strongest evidence for enhanced cognitive ability is therefore derived from studies that use a training task with little resemblance to the outcome measure. | And if youare wondering how often you need to meditate to have an improved sex life, that aspect was not covered in this study. But itas never too late to begin, right? aIt is difficult to be fully present and aroused if we have a abusya mind and are thinking of everything we need to get done that day, for example. | Given that the default network has been repeatedly associated with markers of mind wandering , future research should directly test whether mindfulness training reduces mind wandering by dampening activation of the default network. In principle, the strongest evidence for enhanced cognitive ability is therefore derived from studies that use a training task with little resemblance to the outcome measure. From this perspective, our use of mindfulness training in the present investigation allowed us to provide a rigorous demonstration of cognitive enhancement that cannot be attributed to overlap between training and testing contexts. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33634494848&p=1pl&v=1&x=ozfUlstw5uB_7vK6OrhHsg |
10.1016/j.cell.2017.01.041 | Medicine_easy_570 | "It's possible that such a strategy could also improve the effectiveness of other drugs, such as those that need to reach the brain." | Superposition of each of the two rigid bodies from the apo and LTC 4 -bound forms yields Ca RMSD values of <1 Å ( Figure S5 ). | Since other members of this family also eject drugs, this work has medical relevance beyond MRP1. "Ultimately, we hope these and other structures like them could serve as templates for designing chemotherapy drugs the pumps don't recognize, or inhibitors that block them," Johnson says. "It's possible that such a strategy could also improve the effectiveness of other drugs, such as those that need to reach the brain." | As LTC 4 binds at the interface of the two TM bundles, it serves as a connecting bridge to bring the two halves of the transporter closer together. Superposition of each of the two rigid bodies from the apo and LTC 4 -bound forms yields Ca RMSD values of <1 Å ( Figure S5 ). Several residues, including W553, N1244, W1245, and R1248, reposition their side chains to form proper interactions with LTC 4 ( Figure 6B ; Movie S2). | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/researchers-shed-new-light-on-molecular-pump-that-ejects-anticancer-agents/ |
10.1111/apt.14062 | Medicine_easy_571 | The findings suggest that regular yoga may be a valuable adjunct to conventional medical therapies for ulcerative colitis. | Additional Supporting Information may be found in the online version of this article: | The findings suggest that regular yoga may be a valuable adjunct to conventional medical therapies for ulcerative colitis. Our study suggests that it might be worthwhile to consider yoga as part of a multimodal integrative approach for treating ulcerative colitis," said Prof. Holger Cramer, lead author of the Alimentary Pharmacology Therapeutics study. | Yoga can thus be discussed as a safe, acceptable and effective ancillary intervention for patients with ulcerative colitis and impaired quality of life. Additional Supporting Information may be found in the online version of this article: Bold P-values indicate significant group differences (P < 0.05). | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/yoga-helps-patients-with-ulcerative-colitis/ |
10.1038/s41467-018-05635-1 | Medicine_easy_572 | That's the bottom line," Mahowald said. | 3) 54 . | Both of these studies add nuances to how effective reducing black carbon to improve air quality and reduce climate change will be, according to Natalie Mahowald, the Irving Porter Church Professor of Engineering and Atkinson Center for a Sustainable Future faculty director for the environment, who coauthored the particle-size paper. "We really need to understand more about preindustrial fires and how we're changing the size distribution of the black carbon emissions. That's the bottom line," Mahowald said. | 2 and Supplementary Fig. 3) 54 . A reevaluation of the role of BC in the Earth system using aerosol models which can resolve many MS categories is therefore needed. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37286573745&p=1pl&v=1&x=9uoyBPo_0Au4jjyO_XQmjQ |
10.1038/s41598-019-39913-9 | Medicine_easy_573 | Forskerne bak den lille studien undersokte potensielle effekter av DEHP, en kjemikalie som brukes til a lage plast og finnes i elementer som mobler, gulv, tepper, polstring, leker og sko. | In this latter study, all data was generated from a single laboratory using consistent techniques and thus did not suffer from changes in methodology and quality assurance over the time span encompassed in human meta-analytical studies 9 . | Hunder kan lide av det samme problemet. Forskerne bak den lille studien undersokte potensielle effekter av DEHP, en kjemikalie som brukes til a lage plast og finnes i elementer som mobler, gulv, tepper, polstring, leker og sko. De testet ogsa polyklorert bifenyl 153: den forbudte kjemikalien som finnes i miljoet og har vaert knyttet til mannlig infertilitet. | Temporal trends in human semen quality are paralleled by a similar trend in dogs that live in the human household, where sperm motility declined by 30% over a 26 year period 8 . In this latter study, all data was generated from a single laboratory using consistent techniques and thus did not suffer from changes in methodology and quality assurance over the time span encompassed in human meta-analytical studies 9 . These observations support the hypothesis that temporal trends in semen quality, both in the human and dog, are due to shared environmental factors and that the dog may be a sentinel for human exposure to such factors. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39570151736&p=1pl&v=1&x=SssV8yn22msPHOIzUiXRWg |
10.1126/scitranslmed.aaa5843 | Medicine_easy_574 | It also enhances the ability of the heart to respond to changes brought about by ageing. | *P < 0.05, **P < 0.01, ***P < 0.001, N.S. | This suggests that as individuals grow old, the vinculin in the body rises in order to keep the heart pumping. The insects lived 150 percent longer compared to their normal lifespan. It also enhances the ability of the heart to respond to changes brought about by ageing. | In such models, a relationship between cardiac vinculin expression and clinically relevant functional metrics (pressure-volume relationship, ejection fraction, or In (C) to (E), *P < 0.05, **P < 0.01, compared to control by one-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001, N.S. **P < 0.01, ***P < 10 −6 for population over time versus control, two-way ANOVA. | [1] | Medicine | train | 1 | news | http://www.techtimes.com/articles/61556/20150618/the-secret-to-a-young-and-healthy-heart-researchers-identify-heart-repair-protein.htm |
10.2134/jeq2014.12.0540 | Medicine_easy_576 | We have to remember that those ponds wouldn't be there without the beavers." | Across all sites and seasons, average dry bulk density was 0.33 g cm -3 . | With their return they help solve one of the major problems of the 21st century. I don't want to minimize that. We have to remember that those ponds wouldn't be there without the beavers." | Percentage soil moisture within the soil cores ranged from 70 to 90%, with an average of 79%. Across all sites and seasons, average dry bulk density was 0.33 g cm -3 . Pond C had slightly more acidic soil with a soil pH of 5.5, compared with 6.3 and 6.0 in Ponds A and B, respectively. | [1] | Medicine | train | 1 | news | http://www.terradaily.com/reports/Beavers_take_a_chunk_out_of_nitrogen_in_Northeast_rivers_999.html |
10.1007/s40264-014-0155-x | Medicine_easy_577 | i so dont miss the dreams i had when i was on zoloft -- hayleejean. | Conclusion Patients reporting AEs on Twitter showed a range of sophistication when describing their experience. | These scientists believe these posts have the potential to quickly warn pharmaceutical companies of potential drug reactions. i so dont miss the dreams i had when i was on zoloft -- hayleejean. "For example, a psychiatrist can't see suicidal ideation as an ADR while a patient can describe it perfectly." | Similar overall distribution profiles were observed, with Spearman rank correlation rho of 0.75 (p \ 0.0001) between Proto-AEs reported in Twitter and FAERS by SOC. Conclusion Patients reporting AEs on Twitter showed a range of sophistication when describing their experience. Additional work is needed to improve data acquisition and automation. | [1] | Medicine | train | 1 | news | http://www.inquisitr.com/1914900/up-to-90-percent-of-adverse-reactions-unreported-pharma-companies-search-social-media-to-make-drugs-safer/ |
10.1016/j.neuron.2014.08.013 | Medicine_easy_578 | The surprising result: "We found that in more than half of the cells, the axon does not emerge from the cell body, but arises from a lower dendrite," Thome says. | For all data, *p < 0.05, **p < 0.01, and ***p < 0.001; ns, not significant. | The surprising result: "We found that in more than half of the cells, the axon does not emerge from the cell body, but arises from a lower dendrite," Thome says. "Our measurements indicate that dendrites that are directly connected to the axon, actively propagate even small input stimuli and activate the neuron," says second first author Tony Kelly, a member of the Sonderforschungsbereich (SFB) 1089 at the University of Bonn. A computer simulation of the scientists predicts that this effect is particularly pronounced when the information flow from other dendrites to the axon is suppressed by inhibitory input signals at the cell body. | Higher current injection results in steeper depolarization and typically yields lower action potential thresholds. For all data, *p < 0.05, **p < 0.01, and ***p < 0.001; ns, not significant. Supplemental Information includes eight figures, one table, and three movies and can be found with this article online at http://dx.doi.org/10.1016/j.neuron. | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2014/09/140922091116.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1016/j.pcad.2017.03.005 | Medicine_easy_579 | He sees it particularly around the eyes or crow's feet (likely because of squinting). | Nevertheless, life expectancy is a metric that is easy to understand and could convey a powerful public health message. | "I do find that my patients who are in the gym or running every day and have great metabolisms--their Botox wears off a little more quickly," explains Anolik. He sees it particularly around the eyes or crow's feet (likely because of squinting). Engelman also sees this amongst her active and health-conscious patients. | However, because walking is usually safer and easier to start and sustain, the choice between running and walking should be made not only based on time efficiency, but also individual lifestyle, CRF level, health conditions, and personal preferences. Nevertheless, life expectancy is a metric that is easy to understand and could convey a powerful public health message. We found that runners had a 3.2 years longer life expectancy, compared with non-runners, based on a survival analysis from the ACLS cohort. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39403921692&p=1pl&v=1&x=AB9wNeP9Ym99ZqGW0Wn8CA |
10.1038/s41598-017-08106-7 | Medicine_easy_580 | ---
Image credit: Paul Kozowyk
Comments
comments | Chemical and microscopic analysis of experimental material alongside archaeological remains may help illuminate which methods were likely used in the past by understanding the formation and thermal degradation of biomarkers (cf. | aIt's possible that all three methods we tested, or even some different methods, were used depending on the needs or requirements at the time... My personal favorite is the pit roll method, because it's simple, but still produced reasonable quantities ofA tar,a Kozowyk said in an interview with Seeker. While tar was eventually used for many purposes, he added, it is aunlikelya that the Neanderthals used it for anything other than tool fabrication. ---
Image credit: Paul Kozowyk
Comments
comments | However, the tar lumps themselves may be able to give further insights into the evolution of the technique used. Chemical and microscopic analysis of experimental material alongside archaeological remains may help illuminate which methods were likely used in the past by understanding the formation and thermal degradation of biomarkers (cf. While there are many potential methods of producing tar 26 , we have demonstrated that there are at least three successful aceramic solutions, ranging from low to high-tech. | [1] | Medicine | train | 1 | news | http://www.redorbit.com/news/science/1113418691/researchers-reveal-how-neanderthals-made-the-first-glue/ |
10.3945/jn.109.116640 | Medicine_easy_582 | She shared what worked so well for her with the masses, and the Instagrammable hashtag #Whole30, which to date has spawned 3.4 million posts, was born. | Notwithstanding, the current findings of strong relationships between both whole and refined grain intakes and PAI-1 and the opposing directionality of these associations suggest that the grain variables used in this study adequately differentiated between high and low whole and refined grain consumers, as any misclassification error would have likely been nondifferential and would have tended to bias results toward the null. | She shared what worked so well for her with the masses, and the Instagrammable hashtag #Whole30, which to date has spawned 3.4 million posts, was born. Whole30 involves a lot of diet restriction and willpower, which means the diet may not be the right choice for everyone. In fact, it ranked near the bottom of the list of US News & World Report's 40 best diets of 2018. | The FFQ used in this analysis was limited in its ability to accurately classify whole and refined grain intakes due to lack of specificity of some of the FFQ item lines, as the FFQ was not designed to distinguish between whole and refined grain intakes. Notwithstanding, the current findings of strong relationships between both whole and refined grain intakes and PAI-1 and the opposing directionality of these associations suggest that the grain variables used in this study adequately differentiated between high and low whole and refined grain consumers, as any misclassification error would have likely been nondifferential and would have tended to bias results toward the null. One strength of the FFQ used was that it was modified to include food items that were reported to be regularly consumed by Hispanic and African American residents in the study center areas, which was especially important for measuring grain intakes in ethnic groups, as the foods added to the questionnaire included refined grain products (e.g. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33565657540&p=1pl&v=1&x=rLxgMmzaSOmWVxthTYB20w |
10.1002/oby.21538 | Medicine_easy_583 | "And it's something that never has a finish line. | The magnitude of metabolic adaptation increased 6 years after "The Biggest Loser" competition. | "I think that weight loss is super controversial," said Harper. "And it's something that never has a finish line. Which he sees as more of a constant challenge than a problem. | These observations suggest that metabolic adaptation is a proportional, but incomplete, response to contemporaneous efforts to reduce body weight from its defended baseline or "set point" value . The magnitude of metabolic adaptation increased 6 years after "The Biggest Loser" competition. This was surprising given the relative stability of body weight before the follow-up measurements compared with the substantial negative energy balance at the end of the competition which is known to further suppress RMR . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39890159927&p=1pl&v=1&x=d6KHMAJ56IU315rdfcpknw |
10.1098/rspb.2017.1870 | Medicine_easy_584 | The researches found that people in a higher social class "consistently related to lower levels of wise reasoning," the authors wrote in their paper. | ¼ 0.003). | Affluent people have more resources available to them, and their status might suggest they've made smart decisions about money. The researches found that people in a higher social class "consistently related to lower levels of wise reasoning," the authors wrote in their paper. The results were consistent across different regions of the United States and occurred regardless of people's IQ, age, gender and personality differences in agreeableness, openness to new experiences and consideration of others' emotions. | ¼ 0.013) as compared to the between-state level (s.e. ¼ 0.003). As figure 1 indicates, people from states with higher average social class were less likely to use wise reasoning style about interpersonal experiences from their lives as compared to people from states with lower average social class, r ¼ 20. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=32924247950&p=1pl&v=1&x=r1C2CMK8np2z8Gd9NKhSdw |
10.1038/nature12686 | Medicine_easy_585 | The group plans to make technology, and all the data, available to the broader research community -- -which is especially helpful now that great ape research is severely restricted in the United States and abroad -- -so that other scientists can learn about primates using non-invasive, ethically sound methods. | The reduced levels of A3B in NHP iPS cell were not due to an A3B deletion polymorphism previously described in human individuals 34 (data not shown). | "It could mean that we have gone, as humans, through one or more bottlenecks in evolution, that decrease the variability present in our genome," says Marchetto, though the hypothesis is admittedly hard to prove. The new study provides proof of concept that the iPSC technology can be used to understand some of the evolutionary differences between humans and non-human primates, says Narvaiza. The group plans to make technology, and all the data, available to the broader research community -- -which is especially helpful now that great ape research is severely restricted in the United States and abroad -- -so that other scientists can learn about primates using non-invasive, ethically sound methods. | Relative A3B and PIWIL2 mRNA levels normalized to GAPDH for each individual iPS cell line and fibroblasts are shown in Extended Data Fig. The reduced levels of A3B in NHP iPS cell were not due to an A3B deletion polymorphism previously described in human individuals 34 (data not shown). At this time after transfection, eGFP RNA expressed from retrotransposed L1-eGFP will be insignificant compared to L1-eGFP plasmid-driven expression. | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2013/10/131023141020.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1080/08870446.2013.863883 | Medicine_easy_586 | Eating is no different. | The present study produced an alpha of .79. . | Eating is no different. And since stress is often at the root of overeating, mindfulness seems to make us eat better meals, which means it's likely possible to lose weight without dieting. Apply that to a meal, and mindful eating means actually paying attention to the food you're eating, making you less likely to thoughtlessly plow through a bag of potato chips, for instance. | Before attempting to induce mindfulness without meditation, it is important to show that being higher in the trait of mindfulness and self-compassion results in better weight management. The present study produced an alpha of .79. . The overall scores range from 15 to 90 and the present study produced an alpha of .85. | [1] | Medicine | train | 1 | news | http://time.com/4306564/mindfulness-diet-meditation/ |
10.1111/cobi.12126 | Medicine_easy_587 | Starbucks is at the forefront of a movement that will work to cull contributions to the 8 million metric tons of plastic already in the ocean. | However, because our analyses included feeding studies, in which gut contents are investigated carefully, and studies reporting null ingestion, it is reasonable to expect that observed increases were not due to differences in necropsy methods among studies. | "It's about pointing out how prevalent single-use plastics are in our lives. Starbucks is at the forefront of a movement that will work to cull contributions to the 8 million metric tons of plastic already in the ocean. And while banning straws is only the beginning, it's at least a start. | As more studies were published on debris ingestion, researchers may have become more meticulous in their necropsy techniques. However, because our analyses included feeding studies, in which gut contents are investigated carefully, and studies reporting null ingestion, it is reasonable to expect that observed increases were not due to differences in necropsy methods among studies. Additionally, our finding of increasing plastic ingestion is consistent with findings of other researchers for both turtles and seabirds (e.g., . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34502185755&p=1pl&v=1&x=z0dO6Ks-U6rnp0rIiC7G-w |
10.1016/j.jacc.2018.06.060 | Medicine_easy_588 | In an accompanying editorial, Larry A. Weinrauch, MD, said that the study's small cohort may understate the importance of this problem for ART adolescents, especially since multiple birth pregnancies and maternal risk factors (such as eclampsia, chronic hypertension and diabetes) were excluded from the study. | Five control subjects and 3 ART subjects were taking noncardiac medication during the time of the study. | These limitations may have resulted in a lower cardiovascular risk among the participants compared with the overall ART population. In an accompanying editorial, Larry A. Weinrauch, MD, said that the study's small cohort may understate the importance of this problem for ART adolescents, especially since multiple birth pregnancies and maternal risk factors (such as eclampsia, chronic hypertension and diabetes) were excluded from the study. "Early study, detection and treatment of ART conceived individuals may be the appropriate course of preventative action," Weinrauch wrote. | None of the participants was born prematurely, mean gestational age was comparable in the 2 groups, and there were no pregnancy or perinatal complications. Five control subjects and 3 ART subjects were taking noncardiac medication during the time of the study. In 2 ART participants 24-h ambulatory BP could not be measured for technical reasons. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=35001649487&p=1pl&v=1&x=_q9H1m99amu0WPJ3O9Pclg |
10.1001/jamaoncol.2016.6326 | Medicine_easy_589 | The extremely dense breast is completely white. | Estimates of the PARP are sensitive to changes in category definitions that alter the prevalence and relative risk of the risk factor. | "It's a rather strong risk factor ... not as strong as age or known genetic mutations, but a strong risk factor," Lilge said. The extremely dense breast is completely white. Lumps, including cancers, are white," she said. | These factors represent clinically available information that can and should be used by clinicians to stratify breast cancer risk for improved risk-based screening and primary and secondary prevention efforts. Estimates of the PARP are sensitive to changes in category definitions that alter the prevalence and relative risk of the risk factor. Close attention to risk factor prevalence should be considered when applying our results to other populations. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=40341473566&p=1pl&v=1&x=te6VJw1kLgJ77y75GPojkg |
10.1177/0190272516628298 | Medicine_easy_590 | Yet she also notes that credit cards offer the poor a source of funds that may help them through tough times that would otherwise be worse. | As hypothesized, a much higher rate of exercise at campus facilities is reported on the survey (m = 1.74, s = 1.83) than can be validated in records (m = 1.08, s = 1.57), the difference reaching conventional levels of statistical significance (z = 7.8, p \ .001; see Figure 3 ). | Stavins found that 44% of adults have revolving credit, and these people typically have an outstanding balance of $6,600. It is worrisome that financially strapped Americans are incurring high interest payments on credit cards that reduce their already modest incomes, writes Stavins. Yet she also notes that credit cards offer the poor a source of funds that may help them through tough times that would otherwise be worse. | Comparison of the three data collection procedures demonstrates the effect of directiveness of measurement. As hypothesized, a much higher rate of exercise at campus facilities is reported on the survey (m = 1.74, s = 1.83) than can be validated in records (m = 1.08, s = 1.57), the difference reaching conventional levels of statistical significance (z = 7.8, p \ .001; see Figure 3 ). Similarly, survey data show a higher rate of reported exercise when compared with text message data. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38281280455&p=1pl&v=1&x=DoxDPACO2UT3_YcaZG3y1g |
10.3945/ajcn.110.010926 | Medicine_easy_591 | "A good quality matcha is bright green and smooth. | For intervention groups, the mean change in blood HDL-cholesterol concentrations showed a favorable trend, but it was not significant. | Compared to the powders, matcha in tea bags provides significantly less EGCG. "A good quality matcha is bright green and smooth. An average matcha will be yellow and grainy to touch--the tougher leaves of the tea bush," says Cheadle. | Therefore, safety issues need to be evaluated in the future under conditions of long-term and high-dose exposure. In conclusion, green tea significantly reduced serum total and LDL-cholesterol concentrations, and the changes were not influenced by the type of intervention, treatment doses of green tea catechins, study duration, individual health status, or quality of the study. For intervention groups, the mean change in blood HDL-cholesterol concentrations showed a favorable trend, but it was not significant. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33513986504&p=1pl&v=1&x=ngHC19jbm3s9fGg1jNED9A |
10.3945/ajcn.2010.29269 | Medicine_easy_592 | Each one is not a Love Canal disaster waiting to happen. | This review does not address potential health effects of differences in contaminant content (such as herbicide, pesticide, and fungicide residues) of organically and conventionally produced foodstuffs or of potential wider environmental or occupational health effects of different agricultural practices. | These dumps are not full of nuclear waste. Each one is not a Love Canal disaster waiting to happen. And as for the related notion that plastic is evil, it's yet another example of where environmentalists vastly overstate what scientists have actually found. | Conclusion: From a systematic review of the currently available published literature, evidence is lacking for nutrition-related health effects that result from the consumption of organically produced foodstuffs. This review does not address potential health effects of differences in contaminant content (such as herbicide, pesticide, and fungicide residues) of organically and conventionally produced foodstuffs or of potential wider environmental or occupational health effects of different agricultural practices. Establishing the strength of the existing evidence base that relates to nutrition-related health benefits of organic food consumption will assist policymakers in the development of evidence-based statements on potential public-health gains or risks that result from organic food consumption and support consumers to make informed choices. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=40057830393&p=1pl&v=1&x=c4t85s4dBchhLBbTWqEeyQ |
10.1111/1471-0528.14528 | Medicine_easy_594 | The review of 21 studies* included 20,160 women, and found that participants had 25 per cent better odds of improved health outcomes**, compared with non-participants. | Completed disclosure of interests form available to view online as supporting information. | This is the case regardless of whether or not the treatment is found to be effective in the trial. The review of 21 studies* included 20,160 women, and found that participants had 25 per cent better odds of improved health outcomes**, compared with non-participants. The researchers hope the results may lead to more clinicians offering trials to their patients and more women volunteering for trials in a research area that currently faces many challenges. | None declared. Completed disclosure of interests form available to view online as supporting information. JZ and KK resolved the discrepancies between reviewers on data extraction. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/better-health-for-women-involved-in-clinical-trials/ |
10.1126/science.aac5082 | Medicine_easy_595 | The discovery could lead to significant advances in health care, transportation, electronic communication and other areas. | The stress-strain curves of the HLEC and its silicone-containing layers (Ecoflex and Ecoflex-EL composite) are all coincident, whereas the elastic modulus of the hydrogel is two orders of magnitude lower, allowing the HLEC to stretch freely without delaminating. | Even in this age of smartphones and other electronics wonders, these ideas sound quite futuristic. The discovery could lead to significant advances in health care, transportation, electronic communication and other areas. "This material can stretch with the body of a soft robot, and that's what our group does," Shepherd said, noting that the material has two key properties: "It allows robots to change their color, and it also allows displays to change their shape." | The HLEC (Fig. The stress-strain curves of the HLEC and its silicone-containing layers (Ecoflex and Ecoflex-EL composite) are all coincident, whereas the elastic modulus of the hydrogel is two orders of magnitude lower, allowing the HLEC to stretch freely without delaminating. 2A, data table S3 , and movie S1) show the excellent adhesion between the layers. | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/BO8EfoM22o0/ |
10.1111/bdi.12337 | Medicine_easy_596 | In the study, the ratio of free to bound EPA correlated with clinical bipolar symptoms, specifically mania and tendency towards suicide. | Based on the clinical and neuroinflammatory links between BD and migraine, concurrent lowering of dietary n-6 in BD may also be necessary for effective treatment of bipolar disorder with n-3 PUFA supplementation (103). | "This means that the availability of omega-3 in the body is lower in bipolar subjects," Saunders said. In the study, the ratio of free to bound EPA correlated with clinical bipolar symptoms, specifically mania and tendency towards suicide. However, the researchers did not find altered ratios of omega-3 to omega-6 fatty acids in bipolar subjects. | Interestingly, both the L6 and the H3-L6 groups had increases in UE EPA, specifically, among PUFA (102). Based on the clinical and neuroinflammatory links between BD and migraine, concurrent lowering of dietary n-6 in BD may also be necessary for effective treatment of bipolar disorder with n-3 PUFA supplementation (103). Future studies of the specific signaling pathways and lipid mediators linking n-3 and n-6 PUFA to BD pathogenesis may lead to development of targeted dietary and medication strategies for treating BD. | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/PW-ENSotbzs/ |
10.1105/tpc.17.00020 | Medicine_easy_597 | That's like turning off your radio and finding some songs still play as long as you turn up the volume. | These examples demonstrate that some introns significantly boost expression, even in the absence of prior promoter activity. | The plants still turned blue as long as the gene contained an intron. That's like turning off your radio and finding some songs still play as long as you turn up the volume. A job for the junk
So what does this finding mean? | In other cases, the expression of genes that are weakly active without an intron can be increased 10-fold or more by the addition of an intron . These examples demonstrate that some introns significantly boost expression, even in the absence of prior promoter activity. First, the varying abilities of efficiently spliced introns to increase mRNA accumulation indicate that only certain introns boost mRNA levels beyond the general effects caused by the splicing machinery or exon junction complexes . | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/9UMX1H2x8hI/ |
10.1038/s41467-019-10460-1 | Medicine_easy_598 | This is the first therapeutic punch. | 4E , F), providing strong evidence for genomic instability and mitotic catastrophe. | This is the first therapeutic punch. Our approach could improve the effectiveness of chemotherapy in combination with PARP inhibitors and counteract the systematic resistance that develops with this treatment," said Mes-Masson, a researcher at the CRCHUM and professor at the Universite de Montreal. Future clinical trials in store? | 4D ) and an increase in the micronuclei number (Supplementary Fig. 4E , F), providing strong evidence for genomic instability and mitotic catastrophe. Finally depleting either p21 or Chk2 redirected Olaparib-treated cells from senescence toward cell death, as observed by significantly decreased colony formation (Fig. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39437894437&p=1pl&v=1&x=ZBlmsrltN99UiFj8MtvN6w |
10.1016/j.ijfoodmicro.2018.02.007 | Medicine_easy_599 | advertisement
"In Finland, there is no urgent need to prevent Yersinia infections, but our study can serve as a model for the prevention of other, more serious foodborne infections through phage treatment," says Skurnik. | The genes predicted to encode structural proteins are located between genes g41 and g49. | In this case as well, the phages effectively inhibited bacterial growth. advertisement
"In Finland, there is no urgent need to prevent Yersinia infections, but our study can serve as a model for the prevention of other, more serious foodborne infections through phage treatment," says Skurnik. In the future, decontamination with phages may well be part of the routine in processing food. | In the genome of fHe-Yen3-01, 56 genes were identified, and based on similarity searches, functions could be predicted only for 19 of them. The genes predicted to encode structural proteins are located between genes g41 and g49. 4A) , and the highest similarity was found between fHe-Yen3-01 and the virulent Yersinia phage ϕ80-18 [GenBank accession number: HE956710]. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33356795765&p=1pl&v=1&x=m6cNwovANRXnCyeSTCyreQ |
10.1007/s00401-017-1680-3 | Medicine_easy_600 | "It's all about informed choice. | The findings of multiple foci of tau-positive ATs and NFTs with more intense in the sulcal depths of the frontal and temporal cortices with a perivascular distribution were diagnostic of CTE . | "It is disgraceful nothing concrete has been done since by the FA or the PFA. "It's all about informed choice. On the back of a cigarette packet, smokers can read about risks to their health. | Examination of the brain showed moderate atrophy of the temporal lobes and hippocampi and fenestration of the septum pellucidum, with no evidence of metastatic tumour. The findings of multiple foci of tau-positive ATs and NFTs with more intense in the sulcal depths of the frontal and temporal cortices with a perivascular distribution were diagnostic of CTE . In addition, there was widespread tau pathology supportive of CTE with neuronal and glial inclusions in the superficial cortical layers. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/football-headers-linked-to-brain-damage/ |
10.1126/science.aau9101 | Medicine_easy_601 | The fragments diffuse out of the solution and can be washed away. | The offset of the increased heating energy costs and a more detailed analysis of the overall energy savings can be found in fig. | Lignin is a strong emitter of IR light, so Hu and his colleagues knew they had to ditch it. The fragments diffuse out of the solution and can be washed away. The new wood is more than just strong. | Therefore, cities in the Southwest may be the most suitable for the installation of this material to reduce energy consumption for cooling. The offset of the increased heating energy costs and a more detailed analysis of the overall energy savings can be found in fig. The results show that cities with hot and dry climates have the largest potential cooling energy savings. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39296984172&p=1pl&v=1&x=qrXKCeLX4dRfawhqqfpjUw |
10.1038/s41562-017-0189-z | Medicine_easy_602 | Lakens, 37, thought it was a disastrous idea. | However, the connection between the two quantities can be evaluated for particular test statistics under certain classes of plausible alternatives (Fig. | Lakens, 37, thought it was a disastrous idea. A lower a, or significance level, would require much bigger sample sizes, making many studies impossible. he says, "Why prescribe a single p-value, when science is so diverse?" | By Bayes' rule, this ratio may be written as: There is no unique mapping between the P value and the Bayes factor, since the Bayes factor depends on H 1 . However, the connection between the two quantities can be evaluated for particular test statistics under certain classes of plausible alternatives (Fig. A two-sided P value of 0.05 corresponds to Bayes factors in favour of H 1 that range from about 2.5 to 3.4 under reasonable assumptions about H 1 (Fig. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33040029907&p=1pl&v=1&x=rQXyq8C5Bl3TR5A2u9xAfg |
10.1037/0022-3514.87.5.665 | Medicine_easy_606 | "At a smaller college there are less alternatives, and students are aware of that." | However, the partner's arbitrary experimental code number (e.g., 12-31) happened to be the same as or different from participants' month and day of birth. | "On a larger campus people perceive that they have more flexibility in swapping out their friends," Bahns says. "At a smaller college there are less alternatives, and students are aware of that." Students may invest more in their friendships if they know they can't find someone new or if they think it would be hard to move in and out of relationships easily. | Because of changes in laboratory-space assignments, participants in Study 5a were able to see one another easily during the study, whereas participants in Study 5b were seated in a way that minimized visual contact. However, the partner's arbitrary experimental code number (e.g., 12-31) happened to be the same as or different from participants' month and day of birth. If implicit egotism influences interpersonal attraction, then participants who believe their partners' arbitrary code numbers resemble their own birthday numbers should rate their partners more favorably than usual. | [1] | Medicine | train | 1 | news | http://www.scientificamerican.com/article.cfm?id=a-friend-like-me |
10.3389/neuro.01.1.1.006.2007 | Medicine_easy_607 | If you're a parent, you'll treat your child in a different way." | The presynaptic form of plasticity that is normally observed between these neurons was normal in the VPA treated slices. | These children are hyperfunctional and they can't bear their environment," says Markan. "If you have that view, it changes the way you look at research. If you're a parent, you'll treat your child in a different way." | The results were also found for both layer 2/3 and in layer 5 pyramidal neurons and a closer examination revealed that the boosted plasticity was a postsynaptic form of plasticity. The presynaptic form of plasticity that is normally observed between these neurons was normal in the VPA treated slices. These results indicate that glutamatergic synapses are hyper-plastic in this animal model of autism. | [1] | Medicine | train | 1 | news | http://time.com/3905841/autism-hyperfunctional/ |
10.1001/jamapsychiatry.2015.0575 | Medicine_easy_608 | "So it's incredibly interesting that not only is hearing voices more common than previously thought, but it's not always linked to serious mental illness." | The sequence of these follow-up probe types differed slightly between the first 6 WMH surveys, which were administered in Europe (Belgium, France, Germany, Italy, the Netherlands, and Spain), and those in the remaining 12 countries (eTables 1 and 2 in the Supplement). | These people seem to function reasonably well. "So it's incredibly interesting that not only is hearing voices more common than previously thought, but it's not always linked to serious mental illness." "These people were representative of the general population, not seeking mental health assistance," says McGrath. | The weighted mean response rate is 72.1%. The sequence of these follow-up probe types differed slightly between the first 6 WMH surveys, which were administered in Europe (Belgium, France, Germany, Italy, the Netherlands, and Spain), and those in the remaining 12 countries (eTables 1 and 2 in the Supplement). Respondents may have had more than 1 hallucination and/or delusion type associated with a single episode of PE. | [1] | Medicine | train | 1 | news | http://www.futurity.org/hallucinations-delusions-930802/ |
10.1093/jac/dku079 | Medicine_easy_609 | "But we're keen not to point the finger at these plants. | All E. coli were positive for bla CTX-M and bla TEM , but negative for bla SHV (Table 1) . | "Stricter regulations and higher levels of treatment are needed if we are to halt the rise in antibiotic resistance in the environment," write the authors in their report. "But we're keen not to point the finger at these plants. There's contribution from everywhere." | Downstream of the WWTP, the human-associated ST3103 and ST38 were codominant in 2009, but neither of these STs was detected in 2011 samples, which were dominated by the well-recognized human diseaseassociated types ST131 (20%) and ST167 (25%) [ Table 2 and Table S1 (available as Supplementary data at JAC Online)]. All E. coli were positive for bla CTX-M and bla TEM , but negative for bla SHV (Table 1) . Sequencing revealed all bla CTX-M -bearing isolates in 2011 carried bla CTX-M-15 and 54.5% of isolates in 2009 carried bla CTX-M-15 with the remainder carrying bla CTX-M-1 . | [1] | Medicine | train | 1 | news | http://www.homelandsecuritynewswire.com/dr20140722-sewage-treatment-contributes-to-antibiotic-resistance |
10.3945/jn.113.188441 | Biology_1 | One man tells the AP, while guzzling ramen: "There's no way any study is going to stop me from eating this." | The consumption of instant noodles $2 times/wk was associated with a higher prevalence of metabolic syndrome in women [OR: 1.68; 95% CI: 1.10, 2.55; P-trend < 0.01, P-interaction (gender 3 instant noodle intake) = 0.04] and marginally higher abdominal obesity in women (OR: 1.48; 95% CI: 0.99, 2.21; Ptrend = 0.06) but not in men ( Table 5 ). | Some South Koreans are a little steamed--and defensive--about the study's findings. One man tells the AP, while guzzling ramen: "There's no way any study is going to stop me from eating this." Love for the instant noodle spans generations--it reminds the elderly of post-Korean War recovery and for the young and busy, it's quick and cheap. | The exclusion of participants taking blood pressurelowering or lipid-lowering medications or who had a history of diabetes mellitus did not change the overall associations between dietary patterns and cardiometabolic risk factors. The consumption of instant noodles $2 times/wk was associated with a higher prevalence of metabolic syndrome in women [OR: 1.68; 95% CI: 1.10, 2.55; P-trend < 0.01, P-interaction (gender 3 instant noodle intake) = 0.04] and marginally higher abdominal obesity in women (OR: 1.48; 95% CI: 0.99, 2.21; Ptrend = 0.06) but not in men ( Table 5 ). Consumption of instant noodles once per week was also associated with a higher prevalence of metabolic syndrome in women (OR: 1.26; 95% CI: 1.06, 1.50) but not in men. | [1.0, 2.0, 2.0] | Biology | train | 1.666667 | news | http://www.newser.com/story/192784/new-heart-disease-culprit-ramen.html |
10.1073/pnas.1318978111 | Biology_100 | When the team administered small doses of androgens to mice that were taking the equivalent of medications given to women undergoing IVF therapy, they developed more mature, egg-containing follicles than mice that didn't receive androgens. | Finally, we report that low doses of exogenous androgens enhance gonadotropin-induced ovulation in mice, further demonstrating the critical role that androgens play in follicular development and fertility. | "Androgens are increasing follicle growth and ensuring follicles don't die -- exactly what you want when providing fertility treatment," noted Hammes, who is also the chief of the Division of Endocrinology and Metabolism at UR Medicine's Strong Memorial Hospital. When the team administered small doses of androgens to mice that were taking the equivalent of medications given to women undergoing IVF therapy, they developed more mature, egg-containing follicles than mice that didn't receive androgens. The androgen-treated female mice also released larger numbers of eggs with ovulation. | Interestingly, we find that the scaffold molecule paxillin regulates both processes, making it a critical regulator of AR actions in the ovary. Finally, we report that low doses of exogenous androgens enhance gonadotropin-induced ovulation in mice, further demonstrating the critical role that androgens play in follicular development and fertility. These data may explain reported positive effects of androgens on ovulation rates in women with diminished ovarian reserve. | [4.0, 4.0, 5.0] | Biology | train | 4.333333 | news | http://www.sciencedaily.com/releases/2014/03/140304141948.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1007/s10336-017-1477-0 | Biology_101 | And it's not like the purported new species was even a hybrid - analysis also excluded that probability, leaving the researchers to hypothesise that the 'Liberian' greenbul was just an icterine greenbul with a juvenile nutritional deficiency that caused changes to its plumage. | We therefore believe this fragment to represent part of the true mitochondrial ND2 of Liberian Greenbul. | "We can't say definitively that the Liberian greenbul is the same bird as the icterine greenbul, but we have presented enough evidence that makes any other explanation seem highly unlikely." And it's not like the purported new species was even a hybrid - analysis also excluded that probability, leaving the researchers to hypothesise that the 'Liberian' greenbul was just an icterine greenbul with a juvenile nutritional deficiency that caused changes to its plumage. But despite the thorough genetic analysis and unlikely alternative explanations, we can't yet say that the elusive birds absolutely, definitely don't exist - it looks like once something becomes a species, unspecying it is a tougher ask. | The presumed nuND2 appears to be highly conserved: the two icterinus sequences isolated were identical, 1 bp different from the leucolepis allele, with a further 2 bp distance to albigularis. We therefore believe this fragment to represent part of the true mitochondrial ND2 of Liberian Greenbul. Based on a short fragment of sequence, many of the nodes in the tree have equivocal bootstrap support, and it does not represent a robust greenbul phylogeny. | [4.0, 1.0, 4.0, 2.0] | Biology | train | 2 | news | http://ct.moreover.com/?a=34855042070&p=1pl&v=1&x=Aj2yuZYjg1DHHMgjyQ7rYg |
10.1007/s10336-017-1477-0 | Biology_102 | In the end, the Liberian and icterine greenbuls turned out to share an astonishing amount of genetic similarities, much more than any other two species of greenbul. | We therefore believe this fragment to represent part of the true mitochondrial ND2 of Liberian Greenbul. | According to the data, the most likely explanation for a lack of new Liberian greenbuls is the fact that they don't actually exist. In the end, the Liberian and icterine greenbuls turned out to share an astonishing amount of genetic similarities, much more than any other two species of greenbul. "We can't say definitively that the Liberian greenbul is the same bird as the icterine greenbul, but we have presented enough evidence that makes any other explanation seem highly unlikely." | The presumed nuND2 appears to be highly conserved: the two icterinus sequences isolated were identical, 1 bp different from the leucolepis allele, with a further 2 bp distance to albigularis. We therefore believe this fragment to represent part of the true mitochondrial ND2 of Liberian Greenbul. Based on a short fragment of sequence, many of the nodes in the tree have equivocal bootstrap support, and it does not represent a robust greenbul phylogeny. | [2.0, 2.0, 2.0, 2.0] | Biology | train | 2 | news | http://ct.moreover.com/?a=34855042070&p=1pl&v=1&x=Aj2yuZYjg1DHHMgjyQ7rYg |
10.1007/s10336-017-1477-0 | Biology_103 | And it's not like the purported new species was even a hybrid - analysis also excluded that probability, leaving the researchers to hypothesise that the 'Liberian' greenbul was just an icterine greenbul with a juvenile nutritional deficiency that caused changes to its plumage. | S4 of the ESM), which was heterozygous C/T in the Liberian Greenbul but homozygous C/C in Icterine Greenbul 'ICT05'. | "We can't say definitively that the Liberian greenbul is the same bird as the icterine greenbul, but we have presented enough evidence that makes any other explanation seem highly unlikely." And it's not like the purported new species was even a hybrid - analysis also excluded that probability, leaving the researchers to hypothesise that the 'Liberian' greenbul was just an icterine greenbul with a juvenile nutritional deficiency that caused changes to its plumage. But despite the thorough genetic analysis and unlikely alternative explanations, we can't yet say that the elusive birds absolutely, definitely don't exist - it looks like once something becomes a species, unspecying it is a tougher ask. | The Liberian Greenbul sequence was identical to that of the Icterine Greenbul from Liberia with the exception of one position (see Fig. S4 of the ESM), which was heterozygous C/T in the Liberian Greenbul but homozygous C/C in Icterine Greenbul 'ICT05'. This single SNP difference was verified in forward and reverse sequences. | [3.0, 2.0, 3.0] | Biology | train | 2.666667 | news | http://ct.moreover.com/?a=34855042070&p=1pl&v=1&x=Aj2yuZYjg1DHHMgjyQ7rYg |
10.1139/cjz-2017-0071 | Biology_104 | "Very little is preventing their continued dispersal northward, provided they can survive winters." | 2010) , suggest that very little is preventing their continued dispersal northward, provided they can survive winters. | "Very little is preventing their continued dispersal northward, provided they can survive winters." "It was so exciting because it was further confirmation that this range expansion is still happening and that these animals are probably going to keep moving even further northward as the climate warms and as humans continue to alter the landscape with more agriculture and urbanization," Walsh says. "Very little is preventing their continued dispersal northward, provided they can survive winters," Walsh says. | A lack of substantial landscape barriers for opossums , coupled with their nomadic behavior, illustrated by fathers and offspring discovered up to 33 km apart Beasley et al. 2010) , suggest that very little is preventing their continued dispersal northward, provided they can survive winters. Opossums collared with GPS units in Michigan had home ranges calculated between 10.9 and 200 hectares, depending on the equation used, with no difference between sexes . | [3.0, 5.0, 5.0, 5.0, 5.0] | Biology | train | 4.6 | news | http://www.futurity.org/virginia-opossum-range-1684512/ |
10.1186/s40168-015-0071-z | Biology_105 | The researchers emphasized that the finding does not suggest that breast milk from mothers without an active copy of the gene is less nourishing or healthy. | A broader range of bifidobacterial species were positively correlated with the amounts of overall bifidobacteria within secretor-fed infants than non-secretor-fed infants, suggesting that the presence of 2′-fucosylated sugars allows a broader array of bifidobacterial species to colonize the gut environment. | The research may have applications in a clinical setting for protecting premature infants from a range of intestinal diseases including necrotizing enterocolitis (NEC), a condition that is the second most common cause of death among premature infants in the United States. The researchers emphasized that the finding does not suggest that breast milk from mothers without an active copy of the gene is less nourishing or healthy. Rather, it conveys the subtle and elegant choreography of one part of the human microbiome: The relationships between the mothers' genetics, the composition of her breast milk and the development of thier infants' gut microbiota. | However, there was a large difference in which species of bifidobacteria thrived in each group of infants (defined as a species whose presence tended to lead to domination of the microbiota by bifidobacteria). A broader range of bifidobacterial species were positively correlated with the amounts of overall bifidobacteria within secretor-fed infants than non-secretor-fed infants, suggesting that the presence of 2′-fucosylated sugars allows a broader array of bifidobacterial species to colonize the gut environment. According to our fecal isolate data, bifidobacteria that can grow on 2′-fucosylated substrates are relatively uncommon, but represent a larger proportion of total bifidobacteria in secretor-fed infants, suggesting that this substrate is related to the competitive fitness of these strains. | [1.0, 3.0, 2.0, 2.0, 2.0] | Biology | train | 2 | news | http://www.healthcanal.com/genetics-birth-defects/62224-a-mother-s-genes-can-influence-the-bacteria-in-her-baby-s-gut-researchers-at-uc-davis-have-found.html |
10.1002/emmm.201302567 | Biology_108 | "We observed delayed onset of motor neuron dysfunction; we noted also that SMN2 mis-splicing increases during the late stages of SMA, likely accelerating its progression in the body. | SMN2 mis-splicing was exacerbated during late-stage disease, which should accelerate the decline. | "Our efforts to model the adult form of SMA were successful," says Kentaro Sahashi, M.D., Ph.D., a postdoctoral researcher and neurologist who is first author of the team's new paper. "We observed delayed onset of motor neuron dysfunction; we noted also that SMN2 mis-splicing increases during the late stages of SMA, likely accelerating its progression in the body. We noted, importantly, marked liver and heart pathologies that were related to SMA's progression in adults." | We found that ICV-administered ASO phenocopies adult-onset SMA. SMN2 mis-splicing was exacerbated during late-stage disease, which should accelerate the decline. In addition, systemically administered exon-skipping ASO also affected survival, resulting in striking liver and heart lesions, and the combination of central and peripheral administration exacerbated the pathology. | [3.0, 4.0, 5.0, 4.0, 4.0] | Biology | train | 4 | news | http://www.sciencedaily.com/releases/2013/09/130909093116.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1038/s41467-019-09863-x | Biology_11 | The interdisciplinary research team hope their assessments will provide a better understanding of the socio-economic risks from climate change under different scenarios and help guide policy-makers towards prudent decisions on emissions reduction targets. | Considering the nonlinear Arctic feedbacks makes the 1.5°C target marginally more economically attractive than the 2°C target, although both are statistically equivalent. | In both cases, the primary driver behind the additional costs is the emitted permafrost carbon. The interdisciplinary research team hope their assessments will provide a better understanding of the socio-economic risks from climate change under different scenarios and help guide policy-makers towards prudent decisions on emissions reduction targets. "These two components are set to peak for global temperatures within the range covered by the Paris Agreement, but if the climate warms further, the summer and spring sea ice and land snow covers will retreat further north and the albedo feedback will actually weaken. | Combined, these two factors lead to significant increases in the mean discounted economic effect of climate change: +4.0% ($24.8 trillion) under the 1.5°C scenario, +5.5% ($33.8 trillion) under the 2°C scenario, and +4.8% ($66.9 trillion) under mitigation levels consistent with the current national pledges. Considering the nonlinear Arctic feedbacks makes the 1.5°C target marginally more economically attractive than the 2°C target, although both are statistically equivalent. T he Arctic region is warming twice as fast as the global average 1 , manifested by a decrease in sea ice, snow and glaciers and permafrost degradation relative to their benchmark average states for the period between 1979 and 2005 . | [1.0, 1.0, 2.0, 2.0, 1.0] | Biology | train | 1.4 | news | https://www.sciencedaily.com/releases/2019/04/190423114027.htm |
10.1111/gcb.13276 | Biology_111 | "In our study, we observed a widely variable bleaching and mortality response among corals," Marcelino says. | Coral colonies, inhabiting the same reef and apparently exposed to identical conditions, will bleach and die at different rates Obura, 2001; . | Rainforests of the sea
The index provides a valuable new tool to conservationists and park managers committed to preserving coral reefs and scientists interested in learning more about the hundreds of reef-building corals. "In our study, we observed a widely variable bleaching and mortality response among corals," Marcelino says. "Now, with the index, we have a platform we can use to better understand bleaching mechanisms, both intrinsic and environmental. | Within a bleaching event, coral susceptibility to stress is highly uneven. Coral colonies, inhabiting the same reef and apparently exposed to identical conditions, will bleach and die at different rates Obura, 2001; . Knowing which of many potential factors determine differential bleaching susceptibility among taxa will be essential to understanding bleaching mechanisms, and to preserve, manage, or reconstruct coral assemblages. | [4.0, 4.0, 5.0, 5.0] | Biology | train | 4.5 | news | http://www.futurity.org/coral-reefs-climate-change-1138362/ |
10.1038/s41467-018-08278-4 | Biology_112 | That cartilage is a key part of joints, and shows definite progress in limb regeneration. | The regenerated cartilage grew well beyond the amputation plane (Fig. | Without the proteins, the amputated toes would've healed over as normal. That cartilage is a key part of joints, and shows definite progress in limb regeneration. "These studies provide evidence that treatment of growth factors can be used to engineer a regeneration response from a non-regenerating amputation wound," explain the researchers in their paper. | BMP9 induced a robust chondrogenic response in all of the digits analyzed at 7 days (n = 4). The regenerated cartilage grew well beyond the amputation plane (Fig. 3b) and cells are immunopositive for Sox9 and Acan (Fig. | [5.0, 3.0, 4.0, 2.0, 3.0] | Biology | train | 3.4 | news | http://ct.moreover.com/?a=38466420113&p=1pl&v=1&x=IqxylWeo6-sJ6dtu0xtBJQ |
10.1186/s40168-015-0071-z | Biology_113 | advertisement
The researchers determined that more infants fed by secretor mothers had high levels of bifidobacteria -- 60 percent of infants versus 37.5 percent at day 6 and 80 percent versus 50 percent at day 120 -- and that infants who had more bifidobacteria had lower amounts of milk sugars left over and higher amounts of lactate in their feces. | Bifidobacteria were found to be established (High-Bif qPCR ) earlier in secretorfed infants (60% of infants versus 37.5% at day 6) and more often (80% versus 50% by day 120) ( Figure 5 ). | The delay, the authors said, may be due to difficulties in the infant acquiring a species of bifidobacteria that is geared toward consuming the specific milk sugar delivered by the mother. advertisement
The researchers determined that more infants fed by secretor mothers had high levels of bifidobacteria -- 60 percent of infants versus 37.5 percent at day 6 and 80 percent versus 50 percent at day 120 -- and that infants who had more bifidobacteria had lower amounts of milk sugars left over and higher amounts of lactate in their feces. "The types and levels of bacteria encountered by infants in developing countries is different from the types and levels of bacteria encountered by the babies in our UC Davis cohort, and that might account for some of the differences," he said. | Much of the bifidobacterial abundance difference between the two secretor status milk phenotypes appears to come from variation in the time at which each infant transitions from possessing a Low-Bif qPCR ' gut community to possessing a High-Bif qPCR gut community. Bifidobacteria were found to be established (High-Bif qPCR ) earlier in secretorfed infants (60% of infants versus 37.5% at day 6) and more often (80% versus 50% by day 120) ( Figure 5 ). Of 35 milks from non-secretors, 20 of the matched infant stool samples were Low-Bif qPCR (57.1%). | [3.0, 4.0, 5.0, 4.0, 5.0] | Biology | train | 4.2 | news | http://www.sciencedaily.com/releases/2015/04/150409143035.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1016/j.cell.2013.08.004 | Biology_115 | These drugs also might have broader therapeutic value for patients with mental health issues. | Thus SIK1 provides negative feedback, acting to suppress the effects of light on the clock. | The findings reveal a little bit more about how our internal clocks function. In addition, the research could pave the way for drugs that could bring bodies in tune with the solar cycle more quickly. These drugs also might have broader therapeutic value for patients with mental health issues. | Knockdown of Sik1 within the SCN results in increased behavioral phase shifts and rapid re-entrainment following experimental jet lag. Thus SIK1 provides negative feedback, acting to suppress the effects of light on the clock. This pathway provides a potential target for the regulation of circadian rhythms. | [1.0, 1.0, 3.0, 2.0, 1.0] | Biology | train | 1.6 | news | http://www.scienceworldreport.com/articles/9204/20130902/what-causes-jet-lag-internal-clock-slow-change-time.htm |
10.1073/pnas.1504869112 | Biology_116 | The researchers found that study plots with lianas accumulated 76 percent less biomass over the experimental period due to reduced tree growth and increased tree death. | Lianas, per-unit biomass, have a much stronger competitive effect on trees than do other trees (3), and our findings appear to represent the unique effect of lianas on forest carbon dynamics and not merely the effect of biomass removal. | The researchers found that study plots with lianas accumulated 76 percent less biomass over the experimental period due to reduced tree growth and increased tree death. Extrapolating their results to tropical forests as a whole, the team calculated that lianas could potentially reduce long-term storage of carbon in tropical forests by one-third or more. The study will be useful in guiding scientists working to predict the trajectory of carbon storage as atmospheric concentrations rise, and it may help explain recent observations that the carbon storage capacity of tropical forests is declining. | Because biomass dynamics of lianas are included in the whole-forest estimates, our findings corroborate earlier research that lianas themselves do not compensate for the loss in tree biomass that they cause . Lianas, per-unit biomass, have a much stronger competitive effect on trees than do other trees (3), and our findings appear to represent the unique effect of lianas on forest carbon dynamics and not merely the effect of biomass removal. This point is confirmed by our inclusion of lianas in the biomass calculations in the control plots. | [4.0, 3.0, 5.0] | Biology | train | 4 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/PUyOGba13Ho/ |
10.1098/rsos.180695 | Biology_117 | The survey of U.S. indoor climate preferences in 37 states shows that, on average, Americans keep their home climate similar to the outdoor climate of northeast Africa, with outdoor conditions in west central Kenya the most similar to conditions in American homes. | Overall, we identified the geographical distribution of the global outdoor climate that is most similar to the interiors of our study homes and summarized study home indoor climate preferences. | The survey of U.S. indoor climate preferences in 37 states shows that, on average, Americans keep their home climate similar to the outdoor climate of northeast Africa, with outdoor conditions in west central Kenya the most similar to conditions in American homes. There was some variation in American responses. For example, citizens in North Carolina reported indoor conditions most like those in Namibia, which is in southern Africa and south of the equator. | We found that the indoor climates of our study homes largely matched the TNZ of humans and other primates. Overall, we identified the geographical distribution of the global outdoor climate that is most similar to the interiors of our study homes and summarized study home indoor climate preferences. It would be difficult to convincingly argue that the behaviours leading to the construction of human houses are under direct selection. | [4.0, 3.0, 2.0, 5.0, 4.0] | Biology | train | 3.6 | news | http://ct.moreover.com/?a=38804472041&p=1pl&v=1&x=HgOgei0b1kV3BVEuJ5LhBA |
10.1038/s41467-018-07557-4 | Biology_118 | "This is the first study to explicitly show the amount of fundamental infrastructure potentially at risk across the Northern Hemisphere permafrost area under climate change," Hjort and his colleagues wrote in the paper. | Moreover, we were able to quantify and show the magnitude of infrastructure at risk across the circumpolar permafrost domain. | The team found that 3.6 million people--three quarters of the current population in the Northern Hemisphere permafrost area--may be affected by infrastructure damage from permafrost thaw. "This is the first study to explicitly show the amount of fundamental infrastructure potentially at risk across the Northern Hemisphere permafrost area under climate change," Hjort and his colleagues wrote in the paper. The most vulnerable areas identified in the paper are home to nearly one million people, and contain 36,000 buildings, 13,000 kilometers of roads, and 100 airports. | Consequently, detailed hazard maps and geospatial data-based computations, such as those presented here, are of importance to enable planners and policymakers to identify both high-and low hazard areas when planning future infrastructure at urban and settlement scales 33 . Moreover, we were able to quantify and show the magnitude of infrastructure at risk across the circumpolar permafrost domain. The major advantage of the approach presented here is that hazard quantification can be conducted with any available infrastructure or population dataset (also using planned infrastructure and future population if suitable high-quality datasets and projections are available) and for any policy-relevant global warming scenario. | [3.0, 5.0, 4.0] | Biology | train | 4 | news | http://ct.moreover.com/?a=37954092559&p=1pl&v=1&x=m3BMJF9FCb6eVFPBkTQfrg |
10.1098/rsos.171474 | Biology_119 | The task force also "concluded that violent video game use is a risk factor for adverse outcomes, but found insufficient studies to examine any potential link between violent video game use and delinquency or criminal behavior." | Measurement flexibility also extends to a number of outcome assessments employed in the gaming literature. | That task force "found that violent video game exposure was associated with: an increased composite aggression score; increased aggressive behavior; increased aggressive cognitions; increased aggressive affect, increased desensitization, and decreased empathy; and increased physiological arousal." The task force also "concluded that violent video game use is a risk factor for adverse outcomes, but found insufficient studies to examine any potential link between violent video game use and delinquency or criminal behavior." In Przybylski and Weinstein's review of prior literature, the two researchers strongly argue that earlier research is beset with such problems. | Such a pattern could lead researchers to make the spurious claim that playing the 2004 Xbox game Spider Man 2 is a significant catalyst for adolescent promiscuity . Measurement flexibility also extends to a number of outcome assessments employed in the gaming literature. A similar tractability is present in behavioural measurements of aggression. | [2.0, 1.0, 3.0, 1.0] | Biology | train | 1.75 | news | http://ct.moreover.com/?a=38538076628&p=1pl&v=1&x=7Ko5INusmGh9TtCxVKqTtA |