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10.1073/pnas.1704745114 | Medicine_easy_382 | "Our work has important implications for understanding how crops and weeds grow," said study author George Bassel of the University of Birmingham. | These features are present in the less dormant model (Fig. | This proved the scientists' theory that more seeds would germinate when exposed to varying environments, such as fluctuating temperatures, rather than constant environments and temperatures. "Our work has important implications for understanding how crops and weeds grow," said study author George Bassel of the University of Birmingham. The knowledge gained in the study can be applied to commercial plants and crops to control germination, which may increase crop yields and potentially eliminate the need for herbicides. | 3 ), and these effects increase with the progressive loss of the depth of dormancy . These features are present in the less dormant model (Fig. 1C) and not the highly dormant model (Fig. | [1] | Medicine | train | 1 | news | http://www.natureworldnews.com/articles/38372/20170609/scientists-germinate-brain-plant-crops.htm |
10.1073/pnas.1403984111 | Medicine_easy_383 | "It also highlights the importance of the accurate collection of data as part of their day-to-day patrol work, which is essential to understand and communicate the true proportions of the threat that elephants face." | Annual illegal killing of elephants in the Samburu population during 2009 to 2012 exceeded those of all previous years of monitoring (1998) (1999) (2000) (2001) (2002) (2003) (2004) (2005) (2006) (2007) (2008) with an estimated aggregate of 20.8% of the known elephants illegally killed during that 4-y period. | Such figures cause conservationists alarm, as the study shows over 54 percent is a level of poaching that elephant birth rates are unable to overcome and will lead to population decline. "It also highlights the importance of the accurate collection of data as part of their day-to-day patrol work, which is essential to understand and communicate the true proportions of the threat that elephants face." Both came to similar conclusions. | The population was subjected to unsustainable rates of illegal killing between 2009 and 2012, escalating from a mean of 0.6% (SD = 0.4%) between 1998 and 2008 to a high of 8% in 2011 ( Fig. Annual illegal killing of elephants in the Samburu population during 2009 to 2012 exceeded those of all previous years of monitoring (1998) (1999) (2000) (2001) (2002) (2003) (2004) (2005) (2006) (2007) (2008) with an estimated aggregate of 20.8% of the known elephants illegally killed during that 4-y period. Preliminary numbers from 2013 indicated the annual rate of illegal offtake remained concerning at around 3.7%, although below the peak levels experienced in 2011. | [1] | Medicine | train | 1 | news | http://www.newswise.com/articles/colorado-state-university-study-verifies-more-than-100-000-african-elephants-killed-in-three-years |
10.1073/pnas.1408439111 | Medicine_easy_384 | During the holiday season, populations in cities dropped sharply, while tourist sites such as coastlines and Disneyland Paris boomed. | This ability allows us to follow how population distribution changes through time in relation to the week, the season, or any particular event affecting populations over large spatial extents. | The results showed clear trends in population dynamics across weeks and seasons that traditional survey-based censuses can't reflect, the team reports online today in Proceedings of the National Academy of Sciences. During the holiday season, populations in cities dropped sharply, while tourist sites such as coastlines and Disneyland Paris boomed. They found that the two methods are comparable in accuracy when checked against actual survey-based census data, but estimates from mobile phone data can provide more timely information, down to the hours. | In countries where detailed human population census data are available at high resolution, the main value added is not so much in the gain in spatial resolution, but more in the ability to estimate population numbers and densities at high spatial resolution for any time period. This ability allows us to follow how population distribution changes through time in relation to the week, the season, or any particular event affecting populations over large spatial extents. The relevance of the MP approach is even greater in low-income countries where population distribution data may be scarce, outdated, and unreliable. | [1] | Medicine | train | 1 | news | http://news.sciencemag.org/math/2014/10/taking-census-cellphones |
10.1534/genetics.116.197285 | Medicine_easy_385 | / no comments
LAWRENCE -- Rest easy, folks. | It is clear that there is a need for more detailed modeling of CGD on several fronts. | / no comments
LAWRENCE -- Rest easy, folks. So natural selection favors individuals lacking modified genes and purges a given genetic alteration within a population within a few generations. "By doing that they spread through a population much more quickly." | Note that our theory also allows the assessment of strategies involving the purposeful release of resistance alleles for controlling a drive. It is clear that there is a need for more detailed modeling of CGD on several fronts. Furthermore, resistance alleles may be created if homology-directed repair inserts the driver construct, but introduces errors that prevent it from driving. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/research-shows-nature-can-beat-back-scientific-tinkering-with-genes-of-entire-species/ |
10.1186/s40168-015-0071-z | Medicine_easy_386 | So those women make much less of the special sugar. | Bifidobacteria were found to be established (High-Bif qPCR ) earlier in secretorfed infants (60% of infants versus 37.5% at day 6) and more often (80% versus 50% by day 120) ( Figure 5 ). | "Bifidobacteria sort of push other bacteria out. So those women make much less of the special sugar. And they were right. | Much of the bifidobacterial abundance difference between the two secretor status milk phenotypes appears to come from variation in the time at which each infant transitions from possessing a Low-Bif qPCR ' gut community to possessing a High-Bif qPCR gut community. Bifidobacteria were found to be established (High-Bif qPCR ) earlier in secretorfed infants (60% of infants versus 37.5% at day 6) and more often (80% versus 50% by day 120) ( Figure 5 ). Of 35 milks from non-secretors, 20 of the matched infant stool samples were Low-Bif qPCR (57.1%). | [1] | Medicine | train | 1 | news | http://medcitynews.com/2015/04/one-gene-mother-can-affect-bacteria-babys-gut/ |
10.1073/pnas.1403984111 | Medicine_easy_387 | He credits investments in fighting poachers and hopes that efforts to reduce demand in China for ivory are starting to help. | More broadly, results from application to continental data indicated illegal killing levels were unsustainable for the species between 2010 and 2012, peaking to ∼8% in 2011 which extrapolates to ∼40,000 elephants illegally killed and a probable species reduction of ∼3% that year. | The rate of poaching across Africa seems to have declined to about 5% last year, which is still unsustainable for the population, Wittemyer says. He credits investments in fighting poachers and hopes that efforts to reduce demand in China for ivory are starting to help. "It's not even close to being over." | At the intensively monitored site, illegal killing increased markedly after 2008 and was correlated strongly with the local black market ivory price and increased seizures of ivory destined for China. More broadly, results from application to continental data indicated illegal killing levels were unsustainable for the species between 2010 and 2012, peaking to ∼8% in 2011 which extrapolates to ∼40,000 elephants illegally killed and a probable species reduction of ∼3% that year. Preliminary data from 2013 indicate overharvesting continued. | [1] | Medicine | train | 1 | news | http://news.sciencemag.org/africa/2014/08/poaching-drives-overall-elephant-decline-africa |
10.1007/s40279-014-0157-y | Medicine_easy_388 | Pull a 2-in-1
If your week is packed, you can run on a strength-training day, but it should be low in mileage, duration, and/or effort. | Future researchers should take this into consideration when assigning velocities for economy assessment. | "Every good program should always have at least one complete day of rest, which will help you to avoid overdoing it," says Velasquez. Pull a 2-in-1
If your week is packed, you can run on a strength-training day, but it should be low in mileage, duration, and/or effort. And make sure to hit the weights before the road--doing so ensures you get the most out of your weight training and can maintain form. | Consequently, the most valid measurement of economy may be at specific race velocities and power outputs, rather than an arbitrary submaximal intensity which is commonly used. Future researchers should take this into consideration when assigning velocities for economy assessment. This combined neuromuscular and anaerobic ability may be the differentiating factor for elite endurance performance as successful athletes at world-level can produce high velocities and power outputs to win a race following a sustained period of highintensity exercise (i.e. | [1] | Medicine | train | 1 | news | http://www.womenshealthmag.com/fitness/cardio-and-strength-training |
10.1088/1741-2552/aabc9b | Medicine_easy_389 | The short time periods over which movement was assessed did not permit comparison of the two deep brain stimulation paradigms relative to incidence of dyskinesia, but it is hoped that the variable stimulation will also translate into a reduction in adverse effects when tested over longer time periods. | This approach is helpful for rapid algorithm prototyping and visualization of signals in realtime before implementing fully embedded adaptive DBS, for which algorithm troubleshooting is more challenging. | Because adaptive deep brain stimulation did not continuously stimulate the brain, the system saved about 40 percent of the device's battery energy used during traditional stimulation. The short time periods over which movement was assessed did not permit comparison of the two deep brain stimulation paradigms relative to incidence of dyskinesia, but it is hoped that the variable stimulation will also translate into a reduction in adverse effects when tested over longer time periods. "Instead, our device receives feedback from the motor cortex, far from the stimulation source, providing a more reliable signal." | The stimulation delivered by the Activa SC was not altered during adaptive DBS. This approach is helpful for rapid algorithm prototyping and visualization of signals in realtime before implementing fully embedded adaptive DBS, for which algorithm troubleshooting is more challenging. The "Nexus E" interface allows for simple control algorithms, based on spectral power in pre-specified frequency bands, to be implemented within Activa PC+S . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34175486612&p=1pl&v=1&x=_1eTrGJQyGkkr4UeWUolqA |
10.1080/10635150701775111 | Medicine_easy_390 | Yet, Chih-Ming is confident. | Dorsal scales of foreand hind limbs weakly keeled. | In all three cases, the data was limited, especially in the case of the ecological niche modeling. Yet, Chih-Ming is confident. All results were consistent. | Dorsolateral body scales much larger than dorsal scales. Dorsal scales of foreand hind limbs weakly keeled. Scales of lateral portion of body weakly keeled. | [1] | Medicine | train | 1 | news | http://arstechnica.com/science/2014/06/humans-not-entirely-at-fault-for-passenger-pigeon-extinction/ |
10.1534/genetics.116.197285 | Medicine_easy_391 | It's like the perfect template for repairing your 2007 Honda Civic. | (N e /N )⇡, and N thus simply cancels out in the products u µ (i)⇡(i). | "Obviously that doesn't work most of the time. It's like the perfect template for repairing your 2007 Honda Civic. But organisms use both NHEJ and homology-directed repair. | If the effective population size differs from the census size, this will not affect Equation (17), but will change the establishment probability of a new allele specified by Equation (8). (N e /N )⇡, and N thus simply cancels out in the products u µ (i)⇡(i). Resistance alleles from de novo mutations can only arise as long as the driver has not yet fixed in the population. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/research-shows-nature-can-beat-back-scientific-tinkering-with-genes-of-entire-species/ |
10.1038/s41467-018-06824-8 | Medicine_easy_392 | "It seemed a good place to start." | Analyses of syx1a expression levels relative to the second housekeeping gene GAPDH generated the same statistical outcomes. | The gene, linked to social behavior in a number of animals, was the one that best differentiated social from solitary sweat bees, Kocher says. "It seemed a good place to start." The social bees' gene was about 15 times as active as that of the solitary bees, her team reports today in Nature Communications , making it a strong candidate for the switch to sociality. | 4) . We elected to focus our functional analyses on two of these SNPs because: (1) they showed the highest estimates of divergence (of the seven SNPs in syx1a) between all social and all solitary populations, and (2) these two SNPs were in strong LD with each other (Supplementary Fig. Analyses of syx1a expression levels relative to the second housekeeping gene GAPDH generated the same statistical outcomes. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37425745606&p=1pl&v=1&x=BF9poLDtNwHfjOufQy7mMA |
10.1534/genetics.116.197285 | Medicine_easy_393 | "Obviously that doesn't work most of the time. | Generally, as long as resistance alleles do not carry large costs themselves and provide any fitness advantage over the driver, evolution of resistance from the SGV is practically assured whenever θ > 0.1, whereas it remains unlikely for θ << 0.1 (Fig. | We argue resistance could be thought of as a good thing -- if we know it's going to evolve, we can plan around it, and understand a gene drive is a temporary solution. "Obviously that doesn't work most of the time. It's like the perfect template for repairing your 2007 Honda Civic. | Similarly, lower driver costs decrease π(t) and thus P SGV , as resistance alleles will have a smaller fitness advantage (SI Fig. Generally, as long as resistance alleles do not carry large costs themselves and provide any fitness advantage over the driver, evolution of resistance from the SGV is practically assured whenever θ > 0.1, whereas it remains unlikely for θ << 0.1 (Fig. 2 ), consistent with general results for the probability of adaptation from SGV after an environmental shift [17] . | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/research-shows-nature-can-beat-back-scientific-tinkering-with-genes-of-entire-species/ |
10.1098/rsos.171474 | Medicine_easy_394 | It will still be available this weekend on ESPN's digital channels, including its app. | One noteworthy attempt to bring a measure of harmony to the existing literature is that by Hilgard et al. | The decision comes in the wake of the two shootings that prompted politicians, including President Donald Trump, to say video games that glorify violence could be contributing to the country's shooting epidemic. It will still be available this weekend on ESPN's digital channels, including its app. "Blaming video games is a 'look over there' move instead of a 'look at ourselves' reflection. | This interpretation is not uniform; other analyses of the literature conducted by Sherry and Ferguson provide evidence the GAM framing, and the idea that games cause aggression more broadly, is incomplete, not evidenced or flawed. One noteworthy attempt to bring a measure of harmony to the existing literature is that by Hilgard et al. Their analysis detected the presence of publication bias not uncovered in the original reporting of the data. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39907846044&p=1pl&v=1&x=qR_l8J7Kj5CPAEm_xm1uww |
10.1007/s40279-014-0157-y | Medicine_easy_395 | Pencil it in
Trying to pack all of this into one week may feel overwhelming--it definitely did to me at first, too! | found no difference in w _ VO 2max during a cycling protocol. | In fact, running can actually decrease mobility in certain joints, since the repetitive motion doesn't allow hips and ankles to go through their full ranges of motion. Pencil it in
Trying to pack all of this into one week may feel overwhelming--it definitely did to me at first, too! It's a bit neurotic, but it helps... and now I'm never double-booking during my workout time. | established a significant increase in peak treadmill velocity at _ VO 2max (p \ 0.01; ES = 0.55), whereas Hausswirth et al. found no difference in w _ VO 2max during a cycling protocol. argue that the aerobic system is still strongly involved during a _ VO 2max test, and v _ VO 2max = w _ VO 2max should not be used as a pure measure of endurance-specific muscle power performance. | [1] | Medicine | train | 1 | news | http://www.womenshealthmag.com/fitness/cardio-and-strength-training |
10.1038/s41598-018-26198-7 | Medicine_easy_396 | "Finding changes in both markers of the immune system ramping up its attack on cancer cells as well as markers of inflammation resolution suggests a potentially important link between these two areas of inquiry," Dr. Langevin adds. | While our method of stretching does not fully suspend the animal, since its front feet are allowed to grip a bar of the cage, some stress inevitably results from being restrained by the tail, and muscle activity is required to maintain the stretched posture; in the no stretch group, we did not hold the mice by the tail, as they have a tendency to pull away which can cause inadvertent stretching of tissues. | They highlight the "interesting possibility" that stretching could effectively keep inflammation under control, without suppressing the natural cytotoxic immune response against the cancer cells, and then rescuing the cytotoxic function of exhausted T cells. "Finding changes in both markers of the immune system ramping up its attack on cancer cells as well as markers of inflammation resolution suggests a potentially important link between these two areas of inquiry," Dr. Langevin adds. The authors do acknowledge that the active stretching model in mice is complex, and factors such as mild stress may also be relevant. | One key consideration is that, like exercise, our active stretching model is a complex intervention. While our method of stretching does not fully suspend the animal, since its front feet are allowed to grip a bar of the cage, some stress inevitably results from being restrained by the tail, and muscle activity is required to maintain the stretched posture; in the no stretch group, we did not hold the mice by the tail, as they have a tendency to pull away which can cause inadvertent stretching of tissues. Both active and passive stretching had similar effects compared with anesthesia alone, and there was no significant difference between the effects of active and passive stretching 23 . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34125675804&p=1pl&v=1&x=EIuTbzUDbEKkr7kvXb-kdg |
10.1007/s13187-013-0592-8 | Medicine_easy_397 | Black survivors also are more likely to receive "inadequate post-treatment surveillance" for cancer recurrence, the report says. | Then, I just started to cry because I just knew." | For most cancers, the five-year relative survival rate is lower for black patients than white patients - even after controlling for the stage of a patient's cancer at diagnosis - and much of that disparity appears tied to differences in health insurance coverage, the report notes. Black survivors also are more likely to receive "inadequate post-treatment surveillance" for cancer recurrence, the report says. Racial and ethnic minorities also tend to be underrepresented in large clinical trials - "a major barrier to health equity in cancer treatment," according to the study. | Most survivors did not identify their cancer through conscious preventive measures, but through randomly identifying "a lump" and then conducting a self-breast exam and going to their doctor for diagnostic screening. Then, I just started to cry because I just knew." In retrospect, many women offered advice to encourage African-American women to get screening. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39437519490&p=1pl&v=1&x=hIawzcsvTMkDXewMLvf5FQ |
10.2337/dc12-2084 | Medicine_easy_399 | "This also opens the door for a new approach that could really benefit the lives of these children." | Our study suggests that long-chain omega-3 fatty acids may provide protection to the b-cell after clinical diagnosis of type 1 diabetes. | Diet additions may help youth with Type 1 diabetes keep producing own insulin
Adding foods rich in specific amino and fatty acids to the diets of youth with Type 1 diabetes kept them producing some of their own insulin for up to two years after diagnosis, said researchers at the Gillings School of Global Public Health at the University of North Carolina at Chapel Hill." "This also opens the door for a new approach that could really benefit the lives of these children." Mayer-Davis noted the study reflects subjects eating actual foods rich in these nutrients, not taking supplements. | However, significantly reduced risk of development of islet autoimmunity was associated with increased intake of omega-3 fatty acids among youth genetically susceptible to development of type 1 diabetes (36), although continued follow-up did not reveal subsequent protection against incident type 1 diabetes (37). Our study suggests that long-chain omega-3 fatty acids may provide protection to the b-cell after clinical diagnosis of type 1 diabetes. Our results support further study of the potential role of branched-chain amino acids to enhance sustained insulin production in type 1 diabetes. | [1] | Medicine | train | 1 | news | http://www.healthcanal.com/metabolic-problems/diabetes/40953-diet-additions-may-help-youth-with-type-1-diabetes-keep-producing-own-insulin.html |
10.1001/jamaophthalmol.2017.4816 | Medicine_easy_402 | Even in appointments for which the trainee was not present, the presence of a trainee in a clinic session was correlated with longer mean appointment time (mean, 87.2 versus 80.3 minutes). | The presence of a trainee in a clinic session was associated with longer mean appointment times, even in appointments in which the trainee was not present. | The researchers found that appointments with trainees were significantly longer than appointments in clinic sessions without trainees (mean, 105 versus 80.3 minutes). Even in appointments for which the trainee was not present, the presence of a trainee in a clinic session was correlated with longer mean appointment time (mean, 87.2 versus 80.3 minutes). Among the 33 study physicians, three, one, and 29 had shorter, no change in, and longer mean appointment times when a trainee was present. | Findings In this single-center cohort study of 49 448 outpatient ophthalmology appointments by 33 attending physicians, appointments with residents and fellows were 32% and 30% longer, respectively, than appointments without trainees. The presence of a trainee in a clinic session was associated with longer mean appointment times, even in appointments in which the trainee was not present. Meaning Academic medical centers face potential challenges in maintaining clinical efficiency and medical education, particularly in emerging value-based reimbursement models. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=32519400937&p=1pl&v=1&x=h8CIkB_TZAebA9x0rdJEgQ |
10.1001/jamaoncol.2017.5667 | Medicine_easy_404 | With the MRI model, 18 of 100 fewer biopsies could have been performed, with no increase in missed clinically significant prostate cancers. | Eighteen of 100 fewer biopsies could have been performed, with no increase in the number of patients with missed clinically significant prostate cancers. | The MRI model had a lower false-positive rate than the baseline model at a risk threshold of 20 percent (46 [95 percent confidence interval, 32 to 66 percent] versus 92 percent [95 percent confidence interval, 70 to 100 percent]), with a small reduction in the true-positive rate (89 [95 percent confidence interval, 85 to 96 percent] versus 99 percent [95 percent confidence interval, 89 to 100 percent]). With the MRI model, 18 of 100 fewer biopsies could have been performed, with no increase in missed clinically significant prostate cancers. "The inclusion of MRI-derived parameters in a risk model could reduce the number of unnecessary biopsies while maintaining a high rate of diagnosis of clinically significant prostate cancers," the authors write. | At a risk threshold of 20%, the MRI model had a lower false-positive rate than the baseline model (46% [95% CI, 32%-66%] vs 92% [95% CI, 70%-100%]), with only a small reduction in the true-positive rate (89% [95% CI, 85%-96%] vs 99% [95% CI, 89%-100%]). Eighteen of 100 fewer biopsies could have been performed, with no increase in the number of patients with missed clinically significant prostate cancers. Data acquisition and reporting were consistent with the Standards of Reporting for MRI-targeted Biopsy Studies (START) of the recommendations for the prostate. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33409750483&p=1pl&v=1&x=Eq3brMqNx1jvME6Zq_cliw |
10.1007/s00125-015-3781-7 | Medicine_easy_405 | During the period 1996-2011, a total of 2,832 amputations were performed of which 1,285 were among patients with diabetes and 1,547 among individuals without diabetes. | The total number of amputations amounted to 2,832, of which 1,285 were among individuals with diabetes and 1,547 among individuals without diabetes. | Despite the reductions in amputation rates for people with diabetes, they remained far more likely to have an amputation than those without diabetes. During the period 1996-2011, a total of 2,832 amputations were performed of which 1,285 were among patients with diabetes and 1,547 among individuals without diabetes. Diabetes patients had an 11-times increased rate of BAA relative to persons without diabetes. | The different curves thus start at age of diagnosis and duration of diabetes equal to 0, so it can be seen that the initial high rates decrease in about 1 year and the major effect is then age related. The total number of amputations amounted to 2,832, of which 1,285 were among individuals with diabetes and 1,547 among individuals without diabetes. We found a substantial reduction by calendar time in BAA rates among patients with diabetes of almost 10% per year. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/major-fall-in-diabetes-related-amputations-since-the-1990s/ |
10.1186/s12940-018-0421-y | Medicine_easy_406 | Dow Chemical study produced 'misleading' results
We further found issues which inappropriately decrease the ability of the studies to reveal true effects, including a dosage regimen that resulted in too low exposure of the nursing pups for chlorpyrifos and possibly for chlorpyrifos-methyl, and a failure to detect any neurobehavioral effects of lead nitrate used as positive control in the chlorpyrifos study. | We further found issues which inappropriately decrease the ability of the studies to reveal true effects, including a dosage regimen that resulted in too low exposure of the nursing pups for chlorpyrifos and possibly for chlorpyrifos-methyl, and a failure to detect any neurobehavioral effects of lead nitrate used as positive control in the chlorpyrifos study. | Dow Chemical study produced 'misleading' results
We further found issues which inappropriately decrease the ability of the studies to reveal true effects, including a dosage regimen that resulted in too low exposure of the nursing pups for chlorpyrifos and possibly for chlorpyrifos-methyl, and a failure to detect any neurobehavioral effects of lead nitrate used as positive control in the chlorpyrifos study. Our observations thus suggest that conclusions in test reports submitted by the producer may be misleading. This discrepancy affects the ability of regulatory authorities to perform a valid and safe evaluation of these pesticides. | We noted treatment-related changes in a brain dimension measure for chlorpyrifos at all dose levels tested, although not been reported in the original test summary. We further found issues which inappropriately decrease the ability of the studies to reveal true effects, including a dosage regimen that resulted in too low exposure of the nursing pups for chlorpyrifos and possibly for chlorpyrifos-methyl, and a failure to detect any neurobehavioral effects of lead nitrate used as positive control in the chlorpyrifos study. Our observations thus suggest that conclusions in test reports submitted by the producer may be misleading. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37923386732&p=1pl&v=1&x=tmRJDzIyel0iLSnuaiuv0A |
10.1186/s10194-018-0916-5 | Medicine_easy_407 | "Migraineurs with insomnia experienced a higher headache intensity and impact of headache ... compared to migraineurs without insomnia. | Migraineurs with insomnia experienced a higher headache intensity and impact of headache (HIT-6 score) compared to migraineurs without insomnia (Table 3) . | "These findings suggest that the headache status does not influence the overall severity of insomnia among affected individuals. In contrast, insomnia has a significant impact on the clinical presentation of migraine," the authors stated. "Migraineurs with insomnia experienced a higher headache intensity and impact of headache ... compared to migraineurs without insomnia. | In contrast, insomnia has a significant impact on the clinical presentation of migraine. Migraineurs with insomnia experienced a higher headache intensity and impact of headache (HIT-6 score) compared to migraineurs without insomnia (Table 3) . It is possible that their distinct anatomy and pathophysiology contribute to the contrast findings. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37508029023&p=1pl&v=1&x=NpyIs2Y_TfCnoQt5fi_dUg |
10.1038/s41591-018-0013-y | Medicine_easy_408 | The collaborating teams in Switzerland and Spain claim their findings suggest that in a particular genetic background PM20D1 contributes to neuroprotection against AD. | These findings suggest that in a particular genetic background, PM20D1 contributes to neuroprotection against AD. | Genetically boosting PM20D1 expression in AD mice reduced AD-related pathologies, whereas genetically depleting PM20D1 promoted disease progression. The collaborating teams in Switzerland and Spain claim their findings suggest that in a particular genetic background PM20D1 contributes to neuroprotection against AD. "This variation is associated with the loss of activity of a neuroprotective gene called PM20D1; whoever possesses the variation has a greater probability of suffering from AD, so people carrying these variants could be excellent candidates for clinical prevention trials of the disease in the future," comments co-researcher Manel Esteller, M.D., Ph.D., director of the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), ICREA researcher, and professor of genetics of the University of Barcelona. | In line, genetically increasing or decreasing the expression of PM20D1 reduces and aggravates AD-related pathologies, respectively. These findings suggest that in a particular genetic background, PM20D1 contributes to neuroprotection against AD. When we re-analyzed these biologically and technically independent datasets by focusing exclusively on the comparison between samples from healthy controls and patients with advanced-stage AD, we noted that only one gene, PM20D1, which was previously described as a mQTL , consistently displayed promoter hypermethylation in patients with AD (hereafter referred to as AD samples) than in healthy controls in both studies (Fig. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34070583365&p=1pl&v=1&x=qsJQCFeEwdzOAnJYU5yj9g |
10.1038/s41598-019-41135-y | Medicine_easy_409 | "We have looked at 14 species and among eight open-water and shoreline foraging species that have undergone significant population declines, five were negatively associated with temperature increases," Safeeq said in an email interview. | Finally, among eight open-water and shoreline foraging species that have undergone significant populations declines, five were negatively associated with temperature increases ( Fig. | If they don't find water at their breeding sites, specifically fresh water, they won't be able to survive. "We have looked at 14 species and among eight open-water and shoreline foraging species that have undergone significant population declines, five were negatively associated with temperature increases," Safeeq said in an email interview. The report also found that drier summers lead to saltier wetlands, and that's a major problem for birds that are unaccustomed to a saline environment. | In addition, associations between long-term and large-scale trends in climate and hydrology for waterbird assemblages were evident from a non-metric multidimensional scaling analysis (nMDS; see methods section; Fig. Finally, among eight open-water and shoreline foraging species that have undergone significant populations declines, five were negatively associated with temperature increases ( Fig. Here, we provide evidence that recent climate change is affecting an entire landscape of terrestrial and wetland ecosystems in a complex manner: climate-induced shifts in water volume drive changes in wetland salinity, which determines wetland community composition, which in turn determines waterbird use of the region. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=38788883587&p=1pl&v=1&x=cTbex_LwQXrrjx9pS0d6RQ |
10.1192/bjp.bp.111.101196 | Medicine_easy_410 | Given the and impact of the ADHD, one might have expected that older adults with ADHD would experience impairments in these three areas." | Given the chronicity and impact of the ADHD one might have expected that older adults with ADHD experience impairments in these three areas. | But they add, "Another striking finding is that older adults with ADHD did not differ in living situation, level of education, and income compared with older adults without ADHD. Given the and impact of the ADHD, one might have expected that older adults with ADHD would experience impairments in these three areas." However, the respondents themselves did report that their ADHD had a negative impact on many areas of functioning, currently and in childhood. | Another striking finding is that older adults with ADHD did not differ in living situation, level of education and income compared to older adults without ADHD. Given the chronicity and impact of the ADHD one might have expected that older adults with ADHD experience impairments in these three areas. There are several explanations for this finding. | [5] | Medicine | train | 5 | news | http://psychcentral.com/news/2014/04/15/attention-deficit-symptoms-in-older-people/68528.html |
10.1001/jama.2013.276302 | Medicine_easy_411 | "Additional efforts to foster multipayer participation in global payment systems, such as recent state initiatives and provisions in Pioneer Medicare ACO contracts, may be important," the study states. | Additional efforts to foster multipayer participation in global payment systems, such as recent state initiatives and provisions in Pioneer Medicare ACO contracts, 15,32,33 may be important. | Though these results are encouraging, showing ACOs can have a major effect on healthcare costs and further systemic change, they also present a "free-riding" problem. Since insurers can reap the benefits of an ACO without having value-based contracts themselves, they may be less likely to pursue the model on their own. "Additional efforts to foster multipayer participation in global payment systems, such as recent state initiatives and provisions in Pioneer Medicare ACO contracts, may be important," the study states. | Conversely, cost-reducing spillovers present a free-riding problem to commercial insurers engaged in ACO contracts, since competing insurers with similar provider networks could offer lower premiums without incurring the costs of managing an ACO. Additional efforts to foster multipayer participation in global payment systems, such as recent state initiatives and provisions in Pioneer Medicare ACO contracts, 15,32,33 may be important. Our study had several limitations. | [5] | Medicine | train | 5 | news | http://www.beckershospitalreview.com/accountable-care-organizations/commercial-acos-produce-medicare-savings-study-finds.html |
10.1038/s41390-018-0199-1 | Medicine_easy_412 | "We suggest that the prevention of weight problems in women of childbearing age may benefit their later offspring and could reduce the burden of regulatory problems in infancy and prevent their long-term neurodevelopmental consequences," Girchenko said. | Our findings suggest that prevention of overweight/obesity in women of childbearing age will benefit the offspring by reducing the burden of regulatory problems in infancy and preventing their long-term neurodevelopmental consequences. | The research team confirmed that weight was the primary factor, and not whether the mom had high blood pressure or gestational diabetes. In conclusion, the findings reveal that regulatory problems in infancy may have prenatal origins that can be attributed at least partially to mothers being overweight or obese, said lead author Polina Girchenko, a doctoral student of the University of Helsinki. "We suggest that the prevention of weight problems in women of childbearing age may benefit their later offspring and could reduce the burden of regulatory problems in infancy and prevent their long-term neurodevelopmental consequences," Girchenko said. | In sum, our study showed that infants of overweight/obese mothers displayed higher levels of regulatory behavior problems and were more likely to display problems on multiple areas of behavioral self-regulation. Regulatory behavior problems partially mediated the effects of maternal overweight/obesity on childhood developmental milestones. Our findings suggest that prevention of overweight/obesity in women of childbearing age will benefit the offspring by reducing the burden of regulatory problems in infancy and preventing their long-term neurodevelopmental consequences. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37410791006&p=1pl&v=1&x=kBMJpUsrpIL-rs9R4JEiCg |
10.1001/jamapediatrics.2013.78 | Medicine_easy_414 | The study also found that adolescents whose fathers engaged in weight conversations were significantly more likely to engage in dieting and UWCBs than adolescents whose fathers did not. | This study builds on recent research focusing on fathers and their role in adolescent eating disorders treatment 32, [41] [42] [43] and finds that adolescents whose fathers engaged in weight conversations were significantly more likely to engage in dieting and UWCBs than adolescents whose fathers did not. | The results also indicate that weight conversations from one parent or from both parents were associated with a significantly higher prevalence of dieting relative to parents who engaged in only healthful eating conversations (35.2 percent and 37.1 percent vs. 21.2 percent, respectively). The study also found that adolescents whose fathers engaged in weight conversations were significantly more likely to engage in dieting and UWCBs than adolescents whose fathers did not. "Finally, for parents who may wonder whether talking with their adolescent child about eating habits and weight is useful or detrimental, results from this study indicate that they may want to focus on discussing and promoting healthful eating behaviors rather than discussing weight and size, regardless of whether their child is nonoverweight or overweight," the authors conclude. | This approach may be particularly important for parents of overweight or obese adolescents. This study builds on recent research focusing on fathers and their role in adolescent eating disorders treatment 32, [41] [42] [43] and finds that adolescents whose fathers engaged in weight conversations were significantly more likely to engage in dieting and UWCBs than adolescents whose fathers did not. Thus, it may be important to educate fathers to avoid any form of weight-related conversations with their adolescents. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2013/06/130624172806.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1001/jama.2014.15704 | Medicine_easy_415 | The date of last patient follow-up was May 25, 2013. | The date of last patient follow-up was May 25, 20. | This HBV reactivation risk exists for patients with lymphoma treated with chemotherapies containing the drug rituximab. The date of last patient follow-up was May 25, 2013. The researchers found that the rates were significantly lower for the entecavir group vs the lamivudine group for hepatitis (8.2 percent vs 23.3 percent), HBV-related hepatitis (0 percent vs 13.3 percent), HBV reactivation (6.6 percent vs 30 percent), delayed hepatitis B (0 percent vs 8.3 percent), and chemotherapy disruption (1.6 percent vs 18.3 percent). | The date of last patient follow-up was May 25, 20. Incidence of HBV-related hepatitis was significantly lower for the entecavir group vs the lamivudine group. Due to the increasing incidence of diffuse large B-cell lymphoma and extensive use of the R-CHOP regimen, the risk for HBV reactivation has greatly increased. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2014/12/141216161445.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1001/jama.2014.2850 | Medicine_easy_416 | The authors note that the effects found in this study have to be weighed against costs of the STEMO concept. | These effects have to be weighed against costs of the STEMO concept. | STEMO deployment was not associated with increased risk for intracerebral hemorrhage or 7-day mortality. The authors note that the effects found in this study have to be weighed against costs of the STEMO concept. Depending on the configuration of the vehicle, a single STEMO ambulance costs about $1.4 million. | Nevertheless, even the 15-minute time reduction detected in the catchment area has been associated with better outcomes in larger cohorts. These effects have to be weighed against costs of the STEMO concept. Depending on the configuration of the vehicle, a single STEMO ambulance costs about €1 million (US$1.4 million). | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2014/04/140422162305.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1073/pnas.1317920111 | Medicine_easy_417 | Javey notes that the use of elastic fibers with a small spring constant as the structural component of the whiskers provides large deflection and therefore high strain in response to the smallest applied pressures. | Notably, the use of high-aspect-ratio elastic fibers with small spring constant (see Supporting Information for details) as the structural component of the whiskers provides large deflection and therefore high strain for smallest applied pressures. | "The composite can then be painted or printed onto high-aspect-ratio elastic fibers to form e-whiskers that can be integrated with different user-interactive systems." Javey notes that the use of elastic fibers with a small spring constant as the structural component of the whiskers provides large deflection and therefore high strain in response to the smallest applied pressures. As proof-of-concept, he and his research group successfully used their e-whiskers to demonstrate highly accurate 2D and 3D mapping of wind flow. | The composite can be readily painted or printed on high-aspectratio elastic fibers to form e-whiskers, and eventually be integrated with different user-interactive systems. Notably, the use of high-aspect-ratio elastic fibers with small spring constant (see Supporting Information for details) as the structural component of the whiskers provides large deflection and therefore high strain for smallest applied pressures. The resistivity of the composite films is highly sensitive to mechanical strain and can be readily tuned by changing the composition ratio of the components. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2014/01/140121191452.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1136/bmjopen-2013-002893 | Medicine_easy_418 | "Investing in this area is a vital component to deliver the Olympic legacy and improve the short and long term health of our children," they conclude. | Investing in this area is a vital component to deliver the Olympic legacy and improve the short and long-term health of our children. | "The results of our study provide a useful baseline and strongly suggest that contemporary UK children are insufficiently active, implying that effort is needed to boost [physical activity] among young people to the level appropriate for good health," they write. This is likely to require population wide interventions, they say, including policies to make it easier for kids to walk to school, in a bid to increase physical activity and curb the amount of time they are sedentary. "Investing in this area is a vital component to deliver the Olympic legacy and improve the short and long term health of our children," they conclude. | There are many opportunities to increase PA through sport but also in other areas. The full potential to boost PA will only be realised with a comprehensive policy response that increases time spent in more intense PA and decreases the time spent being sedentary. Investing in this area is a vital component to deliver the Olympic legacy and improve the short and long-term health of our children. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2013/08/130822090511.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1186/s13756-019-0493-7 | Medicine_easy_419 | The impact of specialty level culture, and peer influence appears to be important factors of antibiotic prescribing. | The impact of specialty level culture, and peer influence appears to be significant factors of antibiotic decision-making. | Hospitals were significantly (83% in teaching hospitals, 79% in regional hospitals, p = < 0.01) more likely to have antibiotic policies, when compared to primary care. A surveillance mechanism for antibiotic consumption was reported in 58% (104/178) of teaching hospitals and 62% (98/159) of regional hospitals. The impact of specialty level culture, and peer influence appears to be important factors of antibiotic prescribing. | This study with participants representing 53 countries provides insights into the main components of antibiotic stewardship programmes in different countries and the key factors which influence the antibiotic decision-making of key healthcare professionals. The impact of specialty level culture, and peer influence appears to be significant factors of antibiotic decision-making. These data identify existing gaps in adequate training and education for staff involved in stewardship, and the need for greater participation of nurses and pharmacists to ensure effective and sustainable stewardship programmes. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=38590609963&p=1pl&v=1&x=WFWbZ39ALBU43TNOXZBu6g |
10.1136/injuryprev-2014-041483 | Medicine_easy_421 | "Future efforts should examine whether this association pertains at lower doses." | Future efforts should examine whether this association pertains at lower doses. | "SSRIs appear to increase fracture risk among middle-aged women without psychiatric disorders, an effect sustained over time, suggesting that shorter duration of treatment may decrease this," says Professor Matthew Miller, study lead author and part of the British Medical Journal group. "Future efforts should examine whether this association pertains at lower doses." The researchers emphasized that their research was conducted using only statistical data as a research tool therefore, other factors such as cause and effect links cannot be determined in this study. | Conclusions SSRIs appear to increase fracture risk among middle-aged women without psychiatric disorders, an effect sustained over time, suggesting that shorter duration of treatment may decrease fracture risk. Future efforts should examine whether this association pertains at lower doses. For example, escitalopram improves VMS as well as sleep disturbance related to the perimenopausal condition and improves quality of life. | [5] | Medicine | train | 5 | news | http://www.techtimes.com/articles/64466/20150629/antidepressants-for-menopausal-women-ups-risk-of-bone-fractures-what-to-know.htm |
10.1001/jamapediatrics.2013.455 | Medicine_easy_422 | "Longer breastfeeding duration was associated with higher Peabody Picture Vocabulary Test score at age 3 years (0.21; 95% CI, 0.03-0.38 points per month breastfed) and with higher intelligence on the Kaufman Brief Intelligence Test at age 7 years (0.35; 0.16-0.53 verbal points per month breastfed; and 0.29; 0.05-0.54 nonverbal points per month breastfed)," according to the study results. | RESULTS Adjusting for sociodemographics, maternal intelligence, and home environment in linear regression, longer breastfeeding duration was associated with higher Peabody Picture Vocabulary Test score at age 3 years (0.21; 95% CI, 0.03-0.38 points per month breastfed) and with higher intelligence on the Kaufman Brief Intelligence Test at age 7 years (0.35; 0.16-0.53 verbal points per month breastfed; and 0.29; 0.05-0.54 nonverbal points per month breastfed). | "Longer breastfeeding duration was associated with higher Peabody Picture Vocabulary Test score at age 3 years (0.21; 95% CI, 0.03-0.38 points per month breastfed) and with higher intelligence on the Kaufman Brief Intelligence Test at age 7 years (0.35; 0.16-0.53 verbal points per month breastfed; and 0.29; 0.05-0.54 nonverbal points per month breastfed)," according to the study results. However, the study also noted that breastfeeding duration was not associated with Wide Range Assessment of Memory and Learning scores. As for fish intake (less than 2 servings per week vs. greater than or equal to 2 servings), the relationship between breastfeeding duration and the Wide Range Assessment of Visual Motor Abilities at 3 years of age appeared to be stronger in children of women with higher vs. lower fish intake, although this finding was not statistically significant, the results also indicate. | MAIN EXPOSURE Duration of any breastfeeding to age 12 months. RESULTS Adjusting for sociodemographics, maternal intelligence, and home environment in linear regression, longer breastfeeding duration was associated with higher Peabody Picture Vocabulary Test score at age 3 years (0.21; 95% CI, 0.03-0.38 points per month breastfed) and with higher intelligence on the Kaufman Brief Intelligence Test at age 7 years (0.35; 0.16-0.53 verbal points per month breastfed; and 0.29; 0.05-0.54 nonverbal points per month breastfed). Breastfeeding duration was not associated with Wide Range Assessment of Memory and Learning scores. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2013/07/130729231601.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1016/j.drugalcdep.2013.12.012 | Medicine_easy_423 | "The new DSM-5-AUD criteria has the advantage of shedding light on risky drinkers allowing for preventive and brief interventions, which could reach a large number of individuals. | DSM-5-AUD has the advantage of shedding light on risky drinkers included in the "use in larger amounts class", allowing for preventive interventions, which will reach a large number of individuals. | No link was found between gender and the two problematic alcohol classes, and Dr. Martins suggests this may be a result of the recent trend of increased alcohol use among females in Brazil and worldwide. "The new DSM-5-AUD criteria has the advantage of shedding light on risky drinkers allowing for preventive and brief interventions, which could reach a large number of individuals. Future studies may distinguish additional patterns among users as well," said Dr. Martins. | The two symptomatic classes clearly represented the dimensionality of the new proposed AUD criteria, and could be more specifically targeted by different prevention or treatment strategies. DSM-5-AUD has the advantage of shedding light on risky drinkers included in the "use in larger amounts class", allowing for preventive interventions, which will reach a large number of individuals. As reported by nearly a quarter of all current alcohol users , this totals 11 criteria . | [5] | Medicine | train | 5 | news | http://www.healthcanal.com/mental-health-behavior/47145-study-shows-how-the-new-diagnostic-and-statistical-manual-of-mental-disorders-can-help-at-risk-drinkers.html |
10.1089/trgh.2017.0044 | Medicine_easy_424 | According to the report, "[t]his case illustrates that, in some circumstances, modest but functional lactation can be induced in transgender women." | This case illustrates that, in some circumstances, modest but functional lactation can be induced in transgender women. | The report documents the successful treatment that allowed a 30-year-old trans woman to breastfeed her child, the first ever documented instance of this being possible. According to the report, "[t]his case illustrates that, in some circumstances, modest but functional lactation can be induced in transgender women." After one month of being on the prescribed regimen, which had been used to increase lactation in cisgender women, the woman was able to "express droplets of milk," according to the report. | After implementing a regimen of domperidone, estradiol, progesterone, and breast pumping, she was able to achieve sufficient breast milk volume to be the sole source of nourishment for her child for 6 weeks. This case illustrates that, in some circumstances, modest but functional lactation can be induced in transgender women. The patient's medical history was significant for gender incongruence for which she initiated a feminizing hormone regimen in 2011. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33307118545&p=1pl&v=1&x=CviXLVqLYDLnzmegYXw7BA |
10.1001/archophthalmol.2009.303 | Medicine_easy_425 | "As racial inequities in educational opportunities decreased, near-work exposure may have increased relatively more in black participants than in white participants." | As racial inequities in educational opportunities decreased, near-work exposure may have increased relatively more in black participants than in white participants. | "Black participants surveyed in 1971 to 1972 may have had less access to educational opportunities than white participants and consequently experienced less exposure to near work (a risk factor for myopia)," the authors wrote. "As racial inequities in educational opportunities decreased, near-work exposure may have increased relatively more in black participants than in white participants." The 2009 study is hardly the first to suggest that an increase in years of formal education and access to technology across society may account for higher myopia rates in recent years. | Black participants surveyed in 1971-1972 may have had less access to educational opportunities than white participants and consequently experienced less exposure to near work (a risk factor for myopia ). As racial inequities in educational opportunities decreased, near-work exposure may have increased relatively more in black participants than in white participants. [24] The higher 1999-2004 prevalence rates might be explained by an increased proportion of persons with 12 or more years of formal education. | [5] | Medicine | train | 5 | news | http://www.theatlantic.com/health/archive/2014/05/nearsightedness-and-the-indoor-life/361169/ |
10.1186/s12940-019-0488-0 | Medicine_easy_426 | More than ten percent of total pesticide use in the USA was from pesticide ingredients either banned, not approved or of unknown status in all three of the other nations. | More than 10% of total pesticide use in the USA in 2016 was from pesticide ingredients either banned, not approved or of unknown status in all three agricultural nations (Table 1 and Additional file 5: Table S137 ). | Of the 1.2 billion pounds of pesticides used in US agriculture in 2016, approximately 322 million pounds were pesticides banned in the EU, 40 million pounds were pesticides banned in China and nearly 26 million pounds were pesticides banned in Brazil. More than ten percent of total pesticide use in the USA was from pesticide ingredients either banned, not approved or of unknown status in all three of the other nations. Donley found that of 508 pesticide active ingredients that have been used in agriculture in the USA since 1970, 134 have been cancelled. | Of the 1.2 billion pounds of pesticides used in USA agriculture in 2016, roughly 322 million pounds were of pesticides banned in the EU, 40 million were of pesticides banned in China and nearly 26 million were of pesticides banned in Brazil (Table 1 and Additional file 5: Tables S131-S133 ). More than 10% of total pesticide use in the USA in 2016 was from pesticide ingredients either banned, not approved or of unknown status in all three agricultural nations (Table 1 and Additional file 5: Table S137 ). From 1992 to 2016, the trends in use of the 13 pesticides that are banned in at least two other places and used in the USA varied by pesticide (Fig. | [5] | Medicine | train | 5 | news | https://www.sciencedaily.com/releases/2019/06/190606223504.htm |
10.1186/s12889-017-4672-2 | Medicine_easy_428 | Even though this is an observational study, our findings do not support the hypothesis of adverse effects on child's language, communication and motor skills due to the use of mobile phone during pregnancy." | Our unique findings do not support the hypothesis of adverse effects on children's language, communication and motor skills due to maternal cell phone use during gestation. | These findings provide further evidence that exposure to radio frequency electromagnetic fields associated with maternal use of mobile phones during pregnancy is not linked to neurodevelopment in children. Even though this is an observational study, our findings do not support the hypothesis of adverse effects on child's language, communication and motor skills due to the use of mobile phone during pregnancy." Professor Jan Alexander, senior author from the Norwegian Institute of Public Health, said: "Our investigation revealed for the first time that maternal mobile phone use may actually have a positive impact. | These associations were confirmed by dose-response trends, even after excluding non-users. Our unique findings do not support the hypothesis of adverse effects on children's language, communication and motor skills due to maternal cell phone use during gestation. Nevertheless, in the Spanish study cell phone users had children who scored higher in the Bayley mental scale and in the Danish study there was a trend for lower risk for cognitive/language delay at 6 months [ . | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/mobile-phone-use-while-pregnant-not-linked-to-child-neurodevelopment-problems/ |
10.1001/jama.2015.7515 | Medicine_easy_429 | They note that the absolute cardiovascular event risk of statin-noneligible adults is not much lower with the ACC/AHA guidelines (1 percent) compared with the ATP III guidelines (2.4 percent), and the larger benefit may be that the ACC/AHA guidelines identify many more statin-eligible participants with a similarly high event rate as the ATP III guidelines (6.3 percent vs 6.9 percent). | Although our analyses suggest that adherence to new ACC/AHA statin eligibility guidelines may prove beneficial for the reduction of future cardiovascular events compared with using the ATP III guidelines, the absolute event risk of statinnoneligible adults is not much lower with the ACC/AHA guidelines (1.0%) compared with the ATP III guidelines (2.4%), and the larger benefit may be that the ACC/AHA guidelines identify many more statin-eligible participants with a similarly high event rate as the ATP III guidelines (6.3% vs 6.9%). | The authors write that extrapolating their findings to the approximately 10 million U.S. adults who are newly eligible for statins, an estimated 41,000 to 63,000 incident CVD events would be prevented over a 10-year period by adopting the ACC/AHA guidelines. They note that the absolute cardiovascular event risk of statin-noneligible adults is not much lower with the ACC/AHA guidelines (1 percent) compared with the ATP III guidelines (2.4 percent), and the larger benefit may be that the ACC/AHA guidelines identify many more statin-eligible participants with a similarly high event rate as the ATP III guidelines (6.3 percent vs 6.9 percent). The researchers add that a risk-benefit analysis considering costs and potential adverse effects of statins, especially in patients with prediabetes and in lower-risk patients, is needed to provide a complete assessment of the effects of the change in statin eligibility guidelines on the health care system. | 21 Analogous to their finding that participants with 50% or greater coronary stenosis were more frequently assigned statin therapy with the ACC/AHA guidelines than the ATP III guidelines (90% vs 60%, respectively), we show that those with high-risk CAC scores (>300) are more frequently allocated statin therapy with the ACC/AHA guidelines compared with the ATP III guidelines (5% vs 34%, respectively), and the HR among those with CAC scores greater than 300 for being statin eligible vs noneligible with the ACC/AHA guidelines is considerably higher than with the ATP III guidelines (HRs, 11 vs 3.6, respectively). Although our analyses suggest that adherence to new ACC/AHA statin eligibility guidelines may prove beneficial for the reduction of future cardiovascular events compared with using the ATP III guidelines, the absolute event risk of statinnoneligible adults is not much lower with the ACC/AHA guidelines (1.0%) compared with the ATP III guidelines (2.4%), and the larger benefit may be that the ACC/AHA guidelines identify many more statin-eligible participants with a similarly high event rate as the ATP III guidelines (6.3% vs 6.9%). In addition, a risk-benefit analysis considering costs and potential adverse effects of statins, especially in patients with prediabetes and in lower-risk patients, is needed to provide a complete assessment of the effects of the change in statin eligibility guidelines on the health care system. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/accuracy-of-newer-cholesterol-guidelines-in-identifying-increased-risk-of-cvd-events/ |
10.1073/pnas.1605036113 | Medicine_easy_430 | For ET, indirect effects were, on average, 65 per cent of the size of direct effects. | For ET, indirect effects were, on average, 65% of the size of direct effects. | The simulations suggested that the indirect effects of increased CO2 on net primary productivity (how much carbon dioxide vegetation takes in during photosynthesis minus how much carbon dioxide the plants release during respiration) are large and variable, ranging from less than 10 per cent to more than 100 per cent of the size of direct effects. For ET, indirect effects were, on average, 65 per cent of the size of direct effects. Indirect effects tended to be considerably larger in water-limited ecosystems. | The simulations suggest that the indirect effects of elevated CO 2 on net primary productivity are large and variable, ranging from less than 10% to more than 100% of the size of direct effects. For ET, indirect effects were, on average, 65% of the size of direct effects. Indirect effects tended to be considerably larger in water-limited ecosystems. | [5] | Medicine | train | 5 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/c9qz2n8jSb0/ |
10.1016/j.amepre.2018.05.028 | Medicine_easy_431 | The researchers identified genomic testing barriers including a lack of terminology understanding, health care system mistrust, reluctance to seek medical care, and unfavorable attitudes toward research. | Results: Identified genomic testing barriers included a lack of terminology understanding, healthcare system mistrust, reluctance to seek medical care, and unfavorable attitudes toward research. | Fifty-six participants were included in the study. The researchers identified genomic testing barriers including a lack of terminology understanding, health care system mistrust, reluctance to seek medical care, and unfavorable attitudes toward research. Barriers to research study participation included a lack of prostate cancer knowledge, prostate-specific antigen testing confusion, health care system distrust, and misuse of personal health information. | Because healthcare system mistrust has contributed to these disparities for centuries, black men may be less inclined to pursue novel testing, and identification of facilitators to their participation in prostate cancer research studies remains warranted. Results: Identified genomic testing barriers included a lack of terminology understanding, healthcare system mistrust, reluctance to seek medical care, and unfavorable attitudes toward research. Lack of prostate cancer knowledge, prostate-specific antigen testing confusion, healthcare system distrust, and misuse of personal health information were barriers to research study participation. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37556914670&p=1pl&v=1&x=a-8RKkdSAg5CxnyiRPJ2fQ |
10.1016/j.amepre.2016.07.031 | Medicine_easy_432 | There were 401 HIV-negative participants, of whom 168 (42 percent) were aware of PrEP. | Results: There were 401 HIV-negative participants, of whom 168 (42%) were aware of PrEP. | Side effects are generally mild. There were 401 HIV-negative participants, of whom 168 (42 percent) were aware of PrEP. Having seen a doctor (82 percent had) and having a test for another sexually transmitted disease (46 percent had) in the prior year did not increase the likelihood that a gay or bisexual man knew about PrEP. | Results: There were 401 HIV-negative participants, of whom 168 (42%) were aware of PrEP. Visiting a healthcare provider in the past 12 months, receiving an HIV test from a provider, and having a sexually transmitted infection test in the past 12 months were not significantly associated with PrEP awareness. PrEP awareness was associated with being out to a healthcare provider (OR¼2.97, 95% CI¼1.78, 4.96, po0.001); being tested for HIV (OR¼1.50, 95% CI¼1.06, 2.13, p¼0.023); and receiving condoms from an HIV/AIDS CBO (OR¼2.59, 95% CI¼1.43, 4.64, p¼0.001). | [5] | Medicine | train | 5 | news | http://www.futurity.org/hiv-prep-gay-bisexual-men-1266322-2/ |
10.1377/hlthaff.2014.1428 | Medicine_easy_433 | Thus, their scores on the index-which assesses the effectiveness of both nonmedical and medical exemption policies-would not be accurate, and they are not included in any of the four quartiles. | Thus, their scores on the index-which assesses the effectiveness of both nonmedical and medical exemption policies-would not be accurate, and they are not included in any of the four quartiles. | "Most effective" states are those in the highest quartile of the exemption law effectiveness index; "least effective" states are those in the lowest quartile. Thus, their scores on the index-which assesses the effectiveness of both nonmedical and medical exemption policies-would not be accurate, and they are not included in any of the four quartiles. (Credit: courtesy Health Affairs)
Vaccination exemption rates have increased drastically in the past 10 years, according to the study, due largely to religious and philosophical reasons, which fall under the nonmedical exemption category. | Another component associated with lower exemption rates was the ability to be exempt from text) . Thus, their scores on the index-which assesses the effectiveness of both nonmedical and medical exemption policies-would not be accurate, and they are not included in any of the four quartiles. This reduced exemption rates by 0.7 percent (Exhibit 3). | [5] | Medicine | train | 5 | news | http://www.healthcanal.com/public-health-safety/65883-study-finds-state-policies-influence-vaccination-disease-outbreak-rates.html |
10.1001/jamainternmed.2017.7720 | Medicine_easy_434 | CVD risk did not differ with individual LABA agents, LAMA dosage forms, and concomitant COPD regimens. | Individual LABA agents, LAMA dosage forms, and concomitant COPD regimens did not differ in the CVD risks. | The researchers found that in patients with COPD, new LABA and LAMA use was associated with a 1.5- and 1.52-fold increased cardiovascular risk within 30 days of initiation, respectively; with prevalent use, the risk was absent or reduced. CVD risk did not differ with individual LABA agents, LAMA dosage forms, and concomitant COPD regimens. In an alternative case-crossover study the risk persisted, and it remained across subgroups without history of CVD or prior exacerbations. | New LABA and LAMA use in COPD was associated with a 1.50-fold (95% CI, 1.35-1.67; P < .001) and a 1.52-fold (95% CI, 1.28-1.80; P < .001) increased cardiovascular risk within 30 days of initiation, respectively, whereas the risk was absent, or even reduced with prevalent use. Individual LABA agents, LAMA dosage forms, and concomitant COPD regimens did not differ in the CVD risks. The risk persisted in an alternative case-crossover study and remained across subgroups without CVD history or prior exacerbations. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=32941222539&p=1pl&v=1&x=86oovtifFN21huIJ46h8cQ |
10.1001/jama.2015.7120 | Medicine_easy_435 | In 1 case, blood was sampled after completion of treatment for colorectal cancer and the abnormal pattern was no longer evident. | In 1 case, blood was sampled after completion of treatment for colorectal cancer and the abnormal pattern was no longer evident. | Maternal cancers most frequently occurred with the rare NIPT finding of more than 1 aneuploidy detected (7 known cancers among 39 cases of multiple aneuploidies by NIPT, 18 percent). In 1 case, blood was sampled after completion of treatment for colorectal cancer and the abnormal pattern was no longer evident. aEURoeHere we have shown that occult maternal malignancies may provide a biological explanation for some discordant NIPT results. | All 8 cases that underwent further bioinformatics analysis showed unique patterns of nonspecific copy-number gains and losses across multiple chromosomes. In 1 case, blood was sampled after completion of treatment for colorectal cancer and the abnormal pattern was no longer evident. CONCLUSIONS AND RELEVANCE In this preliminary study, a small number of cases of occult malignancy were subsequently diagnosed among pregnant women whose noninvasive prenatal testing results showed discordance with the fetal karyotype. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/certain-abnormal-prenatal-testing-results-and-subsequent-diagnosis-of-maternal-cancer/ |
10.1016/j.jneb.2017.10.010 | Medicine_easy_436 | "The finding that mothers of children with obesity used more direct imperatives to restrict eating may have important implications for practice guidelines and future research," she says. | The finding that mothers of children with obesity used more direct imperatives to restrict eating may have important implications for practice guidelines and future research. | Pesch says the U-M developmental and behavioral research team plans to further study what language and communication tactics are most effective in encouraging healthy eating among children. "The finding that mothers of children with obesity used more direct imperatives to restrict eating may have important implications for practice guidelines and future research," she says. "Direct imperatives may in fact have a healthy, adaptive role in approaches to feeding to prevent childhood obesity, but we have to do more work to understand the nuances." | In addition, mothers' behavior may have been influenced by knowledge that they were participating in a study about feeding behaviors. The finding that mothers of children with obesity used more direct imperatives to restrict eating may have important implications for practice guidelines and future research. Direct imperatives may have a healthy, adaptive role in approaches to feeding to prevent childhood obesity; they deserve careful consideration in future work. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/moms-of-obese-children-use-different-words-to-restrict-eating/ |
10.1001/jamaophthalmol.2017.4512 | Medicine_easy_437 | "Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care," the authors write. | Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care. | The researchers found that cataract surgery was associated with a 60 percent reduced risk of death from all causes; and a 37 percent to 69 percent reduced risk of death due to pulmonary, accidental, infectious, neurologic and vascular diseases, and cancer. The study notes some limitations, including that because the WHI cohort is all female, findings from this study may not be generalizable to male patients. "Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care," the authors write. | Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care. 6 Furthermore, the WHI database contains information on total and cause-specific mortality, which is not available in other large databases of patients with cataract surgery in the United States. 7 These factors make the WHI an ideal cohort in which to examine the interplay between eye disease and a wide variety of systemic and lifestyle factors in US women. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/cataract-surgery-in-older-women-associated-with-decreased-risk-of-death/ |
10.1001/jamadermatol.2015.1568 | Medicine_easy_438 | "Research regarding the motivations of indoor tanners could inform the development of new interventions," the study states. | 5 Research regarding the motivations of indoor tanners could inform the development of new interventions. | The overall downward trend of the rates is most likely due to increased awareness of these harms among the public along with government mandated regulation, according to researchers. "Research regarding the motivations of indoor tanners could inform the development of new interventions," the study states. "Physicians can also play a role through behavioral counseling, which is recommended for fair-skinned persons aged 10 to 24 years. | The Surgeon General has highlighted the importance of reducing the harms from indoor tanning and of continued public health efforts to identify and implement effective strategies to reduce indoor tanning. 5 Research regarding the motivations of indoor tanners could inform the development of new interventions. Physicians can also play a role through behavioral counseling, which is recommended for fairskinned persons aged 10 to 24 years. | [5] | Medicine | train | 5 | news | http://www.medicaldaily.com/us-indoor-tanning-rates-have-dropped-among-adults-millions-still-do-it-despite-known-340886 |
10.1136/jech-2013-203159 | Medicine_easy_440 | Policies focused only on adult health behaviours do not address the socially patterned causes of these behaviours, or the independent role played by these causes in social inequalities in health." | ▸ Policies focused only on adult health behaviours do not address the socially patterned causes of these behaviours or the independent role played by these causes in social inequalities in health. | Our work provides evidence that social inequalities in health will persist unless prevention strategies tackle the intergenerational transmission of disadvantage and risk." Policies focused only on adult health behaviours do not address the socially patterned causes of these behaviours, or the independent role played by these causes in social inequalities in health." David Buck, Senior Fellow at health think-tank The Kings Fund, says: "We welcome this study which demonstrates how important early life experiences are directly to our long-term health, and how this is reinforced through shaping our health behaviours which then track through to adulthood and early death. | What this study adds ▸ Differences in childhood and early adult circumstances are the underlying causes of social inequalities in both adult health behaviours and mortality. ▸ Policies focused only on adult health behaviours do not address the socially patterned causes of these behaviours or the independent role played by these causes in social inequalities in health. Contributors IG, PG, DK, EB, PH-C and MM made substantial contributions to the conception and design, acquisition of data, or analysis and interpretation of data; and the final approval of the version to be published. | [5] | Medicine | train | 5 | news | http://www.healthcanal.com/public-health-safety/45052-tackling-early-socioeconomic-inequalities-as-important-as-encouraging-smoking-cessation.html |
10.1073/pnas.1716802115 | Medicine_easy_441 | Relative to international mortality trends and to alternative mortality futures simulated by the Social Security Administration, the effect of rising Max BMI was large. | The effect of rising Max BMI is large relative to international mortality trends and to alternative mortality futures simulated by the Social Security Administration. | The results persisted with inclusion of other variables, differences in the measurement of Max BMI, and trend evaluation methods. Relative to international mortality trends and to alternative mortality futures simulated by the Social Security Administration, the effect of rising Max BMI was large. Over the period 1988 to 2011, the increase in Max BMI was estimated to have reduced life expectancy at age 40 years by 0.9 years and to account for 186,000 excess deaths in 2011. | Results were robust to the inclusion of other variables in the model, to differences in how Max BMI was measured, and to how trends were evaluated. The effect of rising Max BMI is large relative to international mortality trends and to alternative mortality futures simulated by the Social Security Administration. The increase in Max BMI over the period 1988-2011 is estimated to have reduced life expectancy at age 40 by 0.9 years in 2011 (95% confidence interval 0.7-1.1 years) and accounted for 186,000 excess deaths that year. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33026953578&p=1pl&v=1&x=jrNtJZM7DM5E6qfK_FW0VQ |
10.1111/jth.13814 | Medicine_easy_442 | "These preliminary data suggest that extended pharmacologic thromboprophylaxis for liver surgery patients is safe and effective," the authors write. | Conclusions: These preliminary data suggest that extended pharmacologic thromboprophylaxis for liver surgery patients is safe and effective. | No pulmonary emboli, other thoracic, splanchnic, or ileofemoral vein thromboses were identified in standard protocol computed tomography scans of the chest/abdomen/pelvis that were obtained from 90.3 percent of patients. Two patients (1.6 percent) had minor bleeding events, and the severe complication rate was 5.6 percent, with no 90-day mortalities. "These preliminary data suggest that extended pharmacologic thromboprophylaxis for liver surgery patients is safe and effective," the authors write. | The severe complication rate was 5.6%, with no 90-day mortalities. Conclusions: These preliminary data suggest that extended pharmacologic thromboprophylaxis for liver surgery patients is safe and effective. The intraoperative, postoperative and overall transfusion rates were 5.6%, 8.1%, and 10.5%, respectively. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/extended-thromboprophylaxis-safe-effective-after-liver-surgery/ |
10.1038/s41467-017-00706-1 | Medicine_easy_444 | This allows the establishment of entanglement between two distant points without requiring one photon to travel the entire distance, thus reducing the effects of decay and loss. | This allows the establishment of entanglement between two distant points without requiring single photons to travel the entire distance, thus reducing the effects of decay and loss. | Increased bit rates can be achieved by using OAM as the carrier of information. This allows the establishment of entanglement between two distant points without requiring one photon to travel the entire distance, thus reducing the effects of decay and loss. It also means that you don't have to have a line of sight between the two places. | This work represents the first step towards a quantum network for high-dimensional entangled states and provides a test bed for fundamental tests of quantum science. This allows the establishment of entanglement between two distant points without requiring single photons to travel the entire distance, thus reducing the effects of decay and loss. Four of these subspaces did not show entanglement prior to the entanglement swapping. | [5] | Medicine | train | 5 | news | http://www.spacedaily.com/reports/Researchers_demonstrate_quantum_teleportation_of_patterns_of_light_999.html |
10.1001/jamainternmed.2018.2259 | Medicine_easy_445 | "For emergency department patients who present with renal colic owing to ureteral stones smaller than 9 mm, tamsulosin does not appear to promote stone passage," the authors write. | Meaning For emergency department patients who present with renal colic owing to ureteral stones smaller than 9 mm, tamsulosin does not appear to promote stone passage. | No secondary outcomes (time to stone passage, return to work, use of analgesic medication, hospitalization, surgical intervention, and repeated emergency department visit) were significant. "For emergency department patients who present with renal colic owing to ureteral stones smaller than 9 mm, tamsulosin does not appear to promote stone passage," the authors write. "Guidelines for medical expulsive therapy for urinary stones may need to be revised." | Findings In this randomized clinical trial of 512 adults, the proportion achieving ureteral stone expulsion by 28 days was 50% with tamsulosin vs 47% with placebo, a nonsignificant difference. Meaning For emergency department patients who present with renal colic owing to ureteral stones smaller than 9 mm, tamsulosin does not appear to promote stone passage. In the 11 cases for which this algorithm did not yield a clear result, the CT scans were individually reviewed and a consensus was reached. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34693276968&p=1pl&v=1&x=zqMPUltMSVjgeeA6mHsw5Q |
10.1001/jamapediatrics.2018.3101 | Medicine_easy_446 | "Reducing exposures of pregnant women to environmental nitric oxide may be associated with a reduction in autism spectrum disorder incidence in their children," the authors write. | Meaning Reducing exposures of pregnant women to environmental nitric oxide may be associated with a reduction in autism spectrum disorder incidence in their children. | For female children, the corresponding odds ratios were 1.03 (95 percent CI, 0.90 to 1.18), 0.98 (95 percent CI, 0.83 to 1.13), and 1.00 (95 percent CI, 0.86 to 1.16). "Reducing exposures of pregnant women to environmental nitric oxide may be associated with a reduction in autism spectrum disorder incidence in their children," the authors write. Abstract/Full Text (subscription or payment may be required) | Findings In this population-based cohort study of 132 256 births, maternal exposure to nitric oxide during pregnancy was associated with increased risk of autism spectrum disorder in offspring. Meaning Reducing exposures of pregnant women to environmental nitric oxide may be associated with a reduction in autism spectrum disorder incidence in their children. The use of LUR models provides greater spatial resolution and the ability to capture small-scale, localized variation compared with reliance on air-quality monitoring data alone. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37748278537&p=1pl&v=1&x=7TKLTgqSS25asY1UBxk9OA |
10.1016/j.clbc.2018.10.008 | Medicine_easy_447 | Both groups held weak beliefs about their need for tamoxifen for current and future health. | Both groups held weak beliefs about their need for tamoxifen for current and future health. | One in five women (19.4 percent) reported a strong need for tamoxifen. Both groups held weak beliefs about their need for tamoxifen for current and future health. However, group 2 (38 percent of the sample) reported stronger concerns about tamoxifen and medicines in general and stronger perceived sensitivity to the negative effects of medicines compared with group 1 (the other 62 percent of the sample). | The model fit statistics supported a 2-group model. Both groups held weak beliefs about their need for tamoxifen for current and future health. Group 2 (38%; 154/406 of the sample) reported stronger concerns about tamoxifen and medicines in general, and stronger perceived sensitivity to the negative effects of medicines compared with group 1 (62%; 252/ 406). | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37983548591&p=1pl&v=1&x=OvjaYTUHs99OZNUUnAjQsA |
10.1186/s12879-018-3112-y | Medicine_easy_448 | Organs should be discarded when rabies is confirmed or suspected. | Organs should be discarded whenever rabies is confirmed or suspected. | Serological testing and etiological diagnosis are recommended for donors with a high risk of rabies or clinically suspected of rabies. Organs should be discarded when rabies is confirmed or suspected. This is especially if the donor is diagnosed with encephalitis of unknown cause. | Four recipients developed rabies that was considered to be transmitted via organ transplantation. Organs should be discarded whenever rabies is confirmed or suspected. A supervisory system is needed to manage donorderived infectious diseases. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34929693402&p=1pl&v=1&x=Crzot8x-PtqrRp874qPYRw |
10.1186/s13601-015-0055-x | Medicine_easy_449 | We believe that more education is required on the importance of strict allergen avoidance and the need for prompt and correct management of anaphylaxis." | Consequently, more education is required on the importance of strict allergen avoidance and the need for prompt and correct management of anaphylaxis. | "Firstly, schools and daycares that allow peanuts may be doing a good job of controlling risk due to heightened awareness of the dangers. "The most significant finding of this study is the discovery that most moderate and severe accidental exposures are managed inappropriately by caregivers and physicians. We believe that more education is required on the importance of strict allergen avoidance and the need for prompt and correct management of anaphylaxis." | Conclusion: Despite increased awareness, accidental exposures continue to occur, mainly at home, and most are managed inappropriately by both health care professionals and caregivers. Consequently, more education is required on the importance of strict allergen avoidance and the need for prompt and correct management of anaphylaxis. Potential predictors for the Cox regression included sex, ethnicity, age at study entry, disease duration, source of recruitment (i.e., food allergy advocacy associations versus allergy clinics), other atopic conditions, severity of initial reaction to peanut, whether the child attended a school prohibiting peanut, and parental factors (i.e., living arrangement, age, level of education and employment). | [5] | Medicine | train | 5 | news | http://www.newswise.com/articles/peanut-allergic-children-are-more-at-risk-of-exposure-at-home-than-at-school |
10.1001/jamapediatrics.2018.0870 | Medicine_easy_450 | When a single serum sample was analyzed from each of 317 patients, median viral loads did not differ significantly according to age, sex, or disposition. | When a single serum sample from each of 317 patients was analyzed, there were no statistically significant differences in median viral loads according to age, sex, or disposition. | The median viral load was higher in serum than in urine among children with serum and urine specimens collected on the same day. When a single serum sample was analyzed from each of 317 patients, median viral loads did not differ significantly according to age, sex, or disposition. The median serum viral load varied significantly according to the number of days after symptom onset, ranging from 106,778 copies/mL at zero days to 15,901 copies/mL at three or more days. | Of 131 children who had both serum and urine specimens collected on the same day, the median viral load was higher in serum than in urine (median [IQR], 23 098 [8784-88 242] copies/mL for serum vs 9966 [2815-52 774] copies/mL for urine; P = .02). When a single serum sample from each of 317 patients was analyzed, there were no statistically significant differences in median viral loads according to age, sex, or disposition. However, the median serum viral load varied significantly according to the number of days after the onset of symptoms (0 days CONCLUSIONS AND RELEVANCE This study represents the largest study to date of ZIKV infection in the pediatric population. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34198674076&p=1pl&v=1&x=IB7urjKbsD_fGqU6lpquOg |
10.1038/s41746-018-0032-6 | Medicine_easy_451 | "Furthermore, continuous activity monitoring may help predict and monitor treatment complications and allow for more timely and appropriate interventions." | Furthermore, continuous activity monitoring during treatment could help predict and monitor treatment complications and allow for timely and appropriate intervention. | "Data gathered through advancements in technology has the potential to help physicians measure the impact of a particular treatment on a patient's daily functioning," Gresham said. "Furthermore, continuous activity monitoring may help predict and monitor treatment complications and allow for more timely and appropriate interventions." As a next step, investigators plan to study long-term use of the monitors in a larger, more diverse group of advanced cancer patients and correlate that data with clinical and self-reported outcomes. | Of additional importance is the possibility of combining objective activity monitoring data with electronically recorded PROs for the purpose of monitoring treatment tolerability and response in future clinical trials. Furthermore, continuous activity monitoring during treatment could help predict and monitor treatment complications and allow for timely and appropriate intervention. Although limited by its small size and short duration, our trial included participants of varying ECOG-PS and KPS ratings allowing for activity estimates in each of the performance status categories. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34627205538&p=1pl&v=1&x=nFGeRoOK2V_03Aqp23SUIQ |
10.1001/jamapediatrics.2018.2537 | Medicine_easy_452 | "Although identifying and treating ACE exposure is important, prioritizing primary prevention of ACEs is critical to improve health and life outcomes throughout the lifespan and across generations," the authors write. | Although identifying and treating ACE exposure is important, prioritizing primary prevention of ACEs is critical to improve health and life outcomes throughout the lifespan and across generations. | Participants who identified as black, Hispanic, or multiracial reported significantly higher ACE exposures (mean scores, 1.69, 1.8, and 2.52, respectively), as did those with less than a high school education (mean score, 1.97), those with income of less than $15,000 per year (mean score, 2.16), those who were unemployed or unable to work (mean scores, 2.3 and 2.33, respectively), and those identifying as gay/lesbian or bisexual (mean scores, 2.19, and 3.14, respectively). The most prevalent ACEs were emotional abuse, parental separation or divorce, and household substance abuse (34.42, 27.63, and 27.56 percent, respectively). "Although identifying and treating ACE exposure is important, prioritizing primary prevention of ACEs is critical to improve health and life outcomes throughout the lifespan and across generations," the authors write. | These findings highlight that childhood adversity is common across sociodemographic characteristics, but some individuals are at higher risk of experiencing ACEs than others. Although identifying and treating ACE exposure is important, prioritizing primary prevention of ACEs is critical to improve health and life outcomes throughout the lifespan and across generations. T he foundation for lifelong health, well-being, and even prosperity is built in childhood. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37160193461&p=1pl&v=1&x=6fvmQHbT6IVvjWqKYgg6uA |
10.1001/jamainternmed.2017.7978 | Medicine_easy_453 | "This study provides longitudinal biochemical evidence that lactation duration is independently associated with lower incidence of diabetes," the authors write. | This study provides longitudinal biochemical evidence that lactation duration is independently associated with lower incidence of diabetes. | There was no modification of the effect by race, gestational diabetes, or parity. "This study provides longitudinal biochemical evidence that lactation duration is independently associated with lower incidence of diabetes," the authors write. "Further investigation is required to elucidate mechanisms that may explain this relationship." | There was no evidence of effect modification by race, GD, or parity. This study provides longitudinal biochemical evidence that lactation duration is independently associated with lower incidence of diabetes. Further investigation is required to elucidate mechanisms that may explain this relationship. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33026953525&p=1pl&v=1&x=fXymZlYbcgFBAOd5jAkOfA |
10.1186/s12887-019-1528-1 | Medicine_easy_454 | Academic performance and executive function scores were found to be positively correlated with age, gender, a- and g-tocopherol, TAC activity, and physical activity score; and negatively correlated with BMI. | The academic performance and executive function scores were found to be positively correlated with age, gender, α-and γ-tocopherol, TAC activity, and PA score; and negatively correlated with BMI. | "On the other hand, significantly higher levels of a- and g-tocopherol [and] total antioxidant capacity activity...were observed in participants in the moderate and high activity groups." Academic performance and executive function scores were found to be positively correlated with age, gender, a- and g-tocopherol, TAC activity, and physical activity score; and negatively correlated with BMI. "Children who face difficulties in learning may benefit from the provision of a balanced diet including vitamin E and other antioxidants," they suggested. | Groups of adolescents who were moderately of highly active were found to have significantly higher levels of vitamin E, TAC activity, LTPA, and academic performance compared with mildly active participants. The academic performance and executive function scores were found to be positively correlated with age, gender, α-and γ-tocopherol, TAC activity, and PA score; and negatively correlated with BMI. Vitamin E levels and TAC activity could be used as indicators for improving executive function, PA and academic performance among students. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=39377367952&p=1pl&v=1&x=zEYBhT0yGmhwB_yLm12nhg |
10.1186/s10194-018-0955-y | Medicine_easy_455 | "We found low to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in patients with episodic migraine and medium to high quality of evidence to recommend erenumab, fremanezumab, and galcanezumab in patients with chronic migraine," wrote the authors.After completing a review of available data, the researchers determined that erenumab, fremanezumab, and galcanezumab are effective for prevention in patients with episodic migraine. | Results: We found low to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in patients with episodic migraine and medium to high quality of evidence to recommend erenumab, fremanezumab, and galcanezumab in patients with chronic migraine. | However, in reviewing available research, the EHF found that there was not enough evidence to provide a guideline based on the Grading of Recommendation, Assessment, Development, and Evaluation approach. "We found low to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in patients with episodic migraine and medium to high quality of evidence to recommend erenumab, fremanezumab, and galcanezumab in patients with chronic migraine," wrote the authors.After completing a review of available data, the researchers determined that erenumab, fremanezumab, and galcanezumab are effective for prevention in patients with episodic migraine. These drugs were found to reduce the number of headache or migraine days, reduce the number of days using acute medications, and improve disability. | Results: We found low to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in patients with episodic migraine and medium to high quality of evidence to recommend erenumab, fremanezumab, and galcanezumab in patients with chronic migraine. For several clinical questions, there was not enough evidence to provide recommendations using the GRADE approach and recommendations relied on experts' opinion. Conclusion: Monoclonal antibodies acting on the calcitonin gene-related peptide are new drugs which can be recommended for migraine prevention. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=38762906591&p=1pl&v=1&x=c2w-_A1-a5S8NGK1QrFyyQ |
10.1001/jamadermatol.2018.0233 | Medicine_easy_456 | "Marital status should be considered when counseling patients for melanoma procedures and when recommending screening and follow-up to optimize patient care," the authors write. | Marital status should be considered when counseling patients for melanoma procedures and when recommending screening and follow-up to optimize patient care. | Married patients were more likely to undergo sentinel lymph node biopsy in lesions with Breslow thickness >1 mm, for which it is routinely recommended, compared with never married, divorced, and widowed patients (odds ratios, 0.59, 0.87, and 0.69, respectively), independent of T stage and other patient factors. "Marital status should be considered when counseling patients for melanoma procedures and when recommending screening and follow-up to optimize patient care," the authors write. Abstract/Full Text (subscription or payment may be required) | Moreover, never married, divorced, and widowed patients are less likely to undergo SLNB for appropriate lesions. Marital status should be considered when counseling patients for melanoma procedures and when recommending screening and follow-up to optimize patient care. [8] Among patients with clinically localized melanoma, a wide range in melanoma-specific survival is characterized by T stage and ulceration status. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33834316760&p=1pl&v=1&x=2_EXvE2OKA56huD06z1NXw |
10.1186/s40337-019-0237-3 | Medicine_easy_457 | On average, participants responded to 96% of the random prompts and reported 4 eating episodes per day. | Participants on average responded to 96% of the random prompts and reported 4 eating episodes per day. | On average, participants responded to 96% of the random prompts and reported 4 eating episodes per day. Of the total eating episodes, 8% were characterized as OBE, and 43% of participants reported at least one OBE episode during the 3-day assessment. Between-person analyses were significant for negative affect (odds ratio, 1.93; P =.02), indicating a 93% increased risk for OBE among individuals with higher negative affect than those with average negative affect. | Level of participation was high. Participants on average responded to 96% of the random prompts and reported 4 eating episodes per day. Participants reported eating 1002 eating episodes during the 3-day period, 80 (8%) of which were characterized as OBE episodes. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=39084406645&p=1pl&v=1&x=y6415bVDpIJumqEEqILv8g |
10.1136/bmj.j5644 | Medicine_easy_458 | "The beneficial effect of improved diet quality on weight management was particularly pronounced in people at high genetic risk for obesity," the authors write. | Moreover, the beneficial effect of improved diet quality on weight management was particularly pronounced in people at high genetic risk for obesity. | Among participants with low, intermediate, and high genetic risk, changes in body mass index per one standard deviation increment of AHEI-2010 score were -0.12, -0.14, and -0.18, respectively (weight changes of -0.35, -0.36, and -0.50 kg, respectively). "The beneficial effect of improved diet quality on weight management was particularly pronounced in people at high genetic risk for obesity," the authors write. Abstract/Full Text
Editorial (subscription or payment may be required) | These data indicate that improving adherence to healthy dietary patterns could attenuate the genetic association with weight gain. Moreover, the beneficial effect of improved diet quality on weight management was particularly pronounced in people at high genetic risk for obesity. Weights reported in questionnaires and measured by technicians were highly correlated (r=0.97 in both studies) in a validation subsample. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=32994759138&p=1pl&v=1&x=bIscXL-eokFPkbnRPYR7Vg |
10.1542/peds.2013-2795 | Medicine_easy_459 | Among youth with type 2 diabetes, DKA was much less common and decreased over time, suggesting improved detection or earlier diagnosis of diabetes. | Among youth with type 2 diabetes, DKA was less common and decreased by ∼10% per year, suggesting improved detection or earlier diagnosis. | Rates were disproportionately high in children younger than 5 years of age, non-White racial/ethnic groups, youth without private health insurance and those with lower family income. Among youth with type 2 diabetes, DKA was much less common and decreased over time, suggesting improved detection or earlier diagnosis of diabetes. Dabelea says "These data suggest that more needs to be done to begin reducing DKA rates in the future. | WHAT THIS STUDY ADDS: DKA in youth with type 1 diabetes remains a problem, with almost one-third presenting with DKA. Among youth with type 2 diabetes, DKA was less common and decreased by ∼10% per year, suggesting improved detection or earlier diagnosis. In youth with type 1 diabetes (n = 5615), the prevalence of DKA was high and stable over time (30.2% in 2002-2003, 29.1% in 2004-2005, and 31.1% in 2008-2010; P for trend = .42). | [5] | Medicine | train | 5 | news | http://www.healthcanal.com/metabolic-problems/diabetes/49282-burden-of-diabetic-ketoacidosis-still-unacceptably-high.html |
10.1377/hlthaff.2015.0215 | Medicine_easy_461 | They found that insurance application rates, successful enrollment, and positive experiences with the ACA were highest in Kentucky, followed by Arkansas, with Texas performing worst. | We found that application rates, successful enrollment, and positive experiences with the ACA were highest in Kentucky, followed by Arkansas, with Texas performing worst on most outcomes. | They found that insurance application rates, successful enrollment, and positive experiences with the ACA were highest in Kentucky, followed by Arkansas, with Texas performing worst. Latinos were equally likely to apply for coverage as other groups, but much less likely to complete the process and obtain coverage. Surprisingly, more than half of low-income adults in the study said they had heard little or nothing about the lawaEUR(tm)s new coverage options. | We found that application rates, successful enrollment, and positive experiences with the ACA were highest in Kentucky, followed by Arkansas, with Texas performing worst on most outcomes. Awareness of the ACA was low -less than half of adults had heard some or a lot about the law. Navigator assistance was the strongest predictor of successful enrollment, while Latinos were much less likely to complete the process. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/survey-finds-state-policies-have-critical-impact-on-aca-applications-enrollment/ |
10.1007/s00198-014-2732-3 | Medicine_easy_464 | The researchers found that at the start of the study, women who took calcium supplements had higher levels of physical activity, smoked less, and had lower trans fat intake compared to women who did not take calcium supplements. | At baseline, women who took calcium supplements had higher levels of physical activity, smoked less, and had lower trans fat intake compared with those who did not take calcium supplements. | "Our study has several distinct strengths compared to prior studies including the large number of participants, long-term follow-up, large number of cardiovascular events that were confirmed by medical record review, detailed information about diet and other cardiovascular disease risk factors, and repeated assessment of calcium supplement use over the 24-year follow up period," said Julie Paik, MD, MPH, BWH Channing Division of Network Medicine, Department of Medicine, lead study author. The researchers found that at the start of the study, women who took calcium supplements had higher levels of physical activity, smoked less, and had lower trans fat intake compared to women who did not take calcium supplements. During the 24 years of follow-up, there were 2,709 heart attacks and 1,856 strokes. | Results During 24 years of follow-up, 4,565 cardiovascular events occurred (2,709 CHD and 1,856 strokes). At baseline, women who took calcium supplements had higher levels of physical activity, smoked less, and had lower trans fat intake compared with those who did not take calcium supplements. After multivariable adjustment for age, body mass index, dietary calcium, vitamin D intake, and other CVD risk factors, the relative risk of CVD for women taking >1,000 mg/day of calcium supplements compared with none was 0.82 (95 % confidence interval [CI] 0.74 to 0.92; p for trend <0.001). | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2014/05/140509130048.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1001/jamaophthalmol.2017.5470 | Medicine_easy_465 | Eliciting or interpreting critical elements of history was the most common diagnostic error, which occurred in 33 percent of patients with alternative diagnoses. | The most common diagnostic error was eliciting or interpreting critical elements of history, which occurred in 24 of 73 patients (33%) with alternative diagnoses. | Headache and eye pain, functional visual loss, and other optic neuropathies were the most common alternative diagnoses. Eliciting or interpreting critical elements of history was the most common diagnostic error, which occurred in 33 percent of patients with alternative diagnoses. Errors weighing or considering alternative diagnoses, errors weighing or interpreting physical examination findings, and misinterpreting diagnostic test results were also common errors (32, 21, and 15 percent, respectively). | The most common alternative diagnoses were headache and eye pain, functional visual loss, and other optic neuropathies, particularly nonarteritic anterior ischemic optic neuropathy. The most common diagnostic error was eliciting or interpreting critical elements of history, which occurred in 24 of 73 patients (33%) with alternative diagnoses. Other common errors included errors weighing or considering alternative diagnoses (23 patients [32%]), errors weighing or interpreting physical examination findings (15 patients [21%]), and misinterpreting diagnostic test results (11 patients [15%]). | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=32721477061&p=1pl&v=1&x=Y4NwLPnnNBNpNGFVlxe7_w |
10.1001/jamaoncol.2017.1261 | Medicine_easy_466 | "Women who have a tumor that is classified as ultralow risk by 70-gene signature can be reassured that their long-term outcome is expected to be excellent, with or without endocrine therapy. | Women who have a tumor that is an ultralow-risk tumor by 70-gene signature can be reassured that their long-term outcome is expected to be excellent, with or without endocrine therapy. | For ultralow risk elderly women over age 75 who have other conditions and face a life expectancy of less than a decade, simple excision may be sufficient, they said. "Women who have a tumor that is classified as ultralow risk by 70-gene signature can be reassured that their long-term outcome is expected to be excellent, with or without endocrine therapy. Having a test that accurately identifies a population of women, who have very little risk to begin with, should be welcomed by patients and clinicians alike. | The ultralow-risk tumors are hormone-positive, mostly luminal A with low proliferation (Ki67 < 15%); however, they are only a small subset of cancers with those characteristics. Women who have a tumor that is an ultralow-risk tumor by 70-gene signature can be reassured that their long-term outcome is expected to be excellent, with or without endocrine therapy. In the tamoxifentreated arm, most had only 2 years of therapy and still had excellent long-term survival. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/test-identifies-breast-cancer-patients-with-lowest-risk-of-death/ |
10.1016/j.yebeh.2013.06.008 | Medicine_easy_470 | While 147 neurologists (29.1 percent) reported initiating carbamazepine treatment in Asian patients, only 33 of them (22.5 percent) said they performed haplotype screening. | While 147 neurologists (29.1%) reported initiating carbamazepine treatment in patients of Asian descent since the warning, only 33 of them (22.5%) said they performed haplotype screening. | The researchers found that 70 percent of the neurologists who responded knew of the recommendation. While 147 neurologists (29.1 percent) reported initiating carbamazepine treatment in Asian patients, only 33 of them (22.5 percent) said they performed haplotype screening. Eighteen neurologists reported that their Asian patients developed carbamazepine-related hypersensitivity reactions -- severe skin rashes that can lead to scarring, blisters in the mouth and shredding of the skin -- during this time period. | FDA recommendation to perform haplotype screening prior to initiating carbamazepine therapy in patients with Asian heritage Seventy percent of respondents reported that they were aware of this 2007 FDA recommendation. While 147 neurologists (29.1%) reported initiating carbamazepine treatment in patients of Asian descent since the warning, only 33 of them (22.5%) said they performed haplotype screening. Eighteen neurologists reported that their patients of Asian descent had developed carbamazepine-related hypersensitivity reactions during this time period. | [5] | Medicine | train | 5 | news | http://www.healthcanal.com/brain-nerves/41944-many-neurologists-unaware-of-safety-risks-related-to-anti-epilepsy-drugs.html |
10.5717/jenb.2014.18.3.249 | Medicine_easy_471 | "It was concluded that the 12 weeks of vitamin D supplementation and circuit training would have positive effects on abdominal fat and blood lipid profiles in T2D and vitamin D deficient elderly women," wrote the researchers. | [Conclusion] It was concluded that the 12 weeks of vitamin D supplementation and circuit training would have positive effects on abdominal fat and blood lipid profiles in T2D and vitamin D deficient elderly women. | Those in the vitamin D and circuit training group saw even more improvements, including lower fasting insulin and glucose levels. "It was concluded that the 12 weeks of vitamin D supplementation and circuit training would have positive effects on abdominal fat and blood lipid profiles in T2D and vitamin D deficient elderly women," wrote the researchers. "Vitamin D supplementation was especially effective when it was complemented with exercise training." | 4) Fasting glucose, fasting insulin, and HOMA-IR tended to be lower in D+T. [Conclusion] It was concluded that the 12 weeks of vitamin D supplementation and circuit training would have positive effects on abdominal fat and blood lipid profiles in T2D and vitamin D deficient elderly women. Vitamin D supplementation was especially effective when it was complemented with exercise training. | [5] | Medicine | train | 5 | news | http://www.theepochtimes.com/n3/1224245-vitamin-d-combined-with-exercise-is-crucial-for-reversing-insulin-resistance-in-type-2-diabetics-study-shows/ |
10.1111/dom.13336 | Medicine_easy_472 | There were non-linear associations with diabetes for age at menarche, parity, and age at first birth. | Non-linear associations with diabetes were observed for age at menarche, parity and age at first birth. | The researchers found that over a median follow-up of nine years, 4,073 cases of diabetes were reported. There were non-linear associations with diabetes for age at menarche, parity, and age at first birth. Menarche at <=10 years was associated with an 18 percent increased risk of diabetes after adjustment for BMI, compared with menarche at age 13 years. | Results: Over a median follow-up of 9 years, 4073 cases of diabetes were reported. Non-linear associations with diabetes were observed for age at menarche, parity and age at first birth. Notable trends in the prevalence of female-specific risk factors such as an increase in the rate of gestational diabetes (itself, a major risk factor for diabetes) observed in populations, 11 and a decline in the mean age of menarche 12 (in part attributable to the increase in childhood obesity) have added to the speculation that they may play a role in the diabetes pandemic. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33959353279&p=1pl&v=1&x=fJcnxDYhIvLteA1Lt9SuQA |
10.1089/apc.2017.0171 | Medicine_easy_473 | "This finding is particularly troubling, given that the highest rates of new HIV infection are in the South, and southern blacks have a higher prevalence of HIV there than other ethnic groups," study authors noted. | This finding is particularly troubling, given that the highest rates of new HIV infection are in the South, and southern blacks have a higher prevalence of HIV there than other ethnic groups. | Lack of insurance was cited as a barrier by 15% of respondents who did not use PrEP. "This finding is particularly troubling, given that the highest rates of new HIV infection are in the South, and southern blacks have a higher prevalence of HIV there than other ethnic groups," study authors noted. Regional disparities must also be overcome. | These regional disparities might reflect the more limited expansion of Medicaid in the south than in the rest of the country. This finding is particularly troubling, given that the highest rates of new HIV infection are in the South, and southern blacks have a higher prevalence of HIV there than other ethnic groups. Lower education frequently coincides with lower health literacy and reduced knowledge of preventive services such as PrEP. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33794251881&p=1pl&v=1&x=FcO5IgoNkIDHnFFfmx6DSQ |
10.1001/jamacardio.2018.1511 | Medicine_easy_474 | "Demographic, clinical, socioeconomic, belief-related, and clinician differences contributed to observed differences and represent potential targets for intervention," the authors write. | Demographic, clinical, socioeconomic, belief-related, and clinician differences contributed to observed differences and represent potential targets for intervention. | After adjustment for demographic, clinical, and clinician factors; socioeconomic status; and patient beliefs, the group differences in statin undertreatment were not significant. "Demographic, clinical, socioeconomic, belief-related, and clinician differences contributed to observed differences and represent potential targets for intervention," the authors write. Several authors disclosed financial ties to pharmaceutical companies, including Sanofi and Regeneron Pharmaceuticals, both of which partially funded the PALM Registry. | CONCLUSIONS AND RELEVANCE African American individuals were less likely to receive guideline-recommended statin therapy. Demographic, clinical, socioeconomic, belief-related, and clinician differences contributed to observed differences and represent potential targets for intervention. Part of the explanation for this increased risk may be undertreatment of African American peoples for primary prevention. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34305773648&p=1pl&v=1&x=SRMGhcUEOmnUBC4TA3jq6w |
10.1007/s10549-019-05226-8 | Medicine_easy_475 | Significantly smaller increases in 10-year DR rates with the increasing EPclin score were seen for women who received ET + C compared with those receiving ET alone (EPClin = 5; 12 percent for ET + C versus 20 percent for ET alone). | Women who received ET + C had significantly smaller increases in 10-year DR rates with the increasing EPclin score than those receiving ET alone (EPclin = 5; 12% ET + C vs. 20% ET alone). | The researchers found that in women who received ET alone and in those who received ET + C, EPclin was highly prognostic for DR (hazard ratios, 2.79 and 2.27, respectively). Significantly smaller increases in 10-year DR rates with the increasing EPclin score were seen for women who received ET + C compared with those receiving ET alone (EPClin = 5; 12 percent for ET + C versus 20 percent for ET alone). A significant positive interaction was seen between EPclin and treatment groups. | Results EPclin was highly prognostic for DR in women who received ET alone (HR 2.79 (2.49-3.13), P < 0.0001) as well as in those who received ET + C (HR 2.27 (1.99-2.59), P < 0.0001). Women who received ET + C had significantly smaller increases in 10-year DR rates with the increasing EPclin score than those receiving ET alone (EPclin = 5; 12% ET + C vs. 20% ET alone). We observed a significant positive interaction between EPclin and treatment groups (P-interaction = 0.022). | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=39175818639&p=1pl&v=1&x=xKDJaFBDNHKJMwZHYcOoJQ |
10.1038/nature22346 | Medicine_easy_476 | A confirmation of these results would point to new particles or interactions and could have profound implications for the understanding of particle physics. | A confirmation of these results would point to new particles or interactions, and could have profound implications for our understanding of particle physics. | However, Franco Sevilla noted, the fact that all three experiments observed a higher-than-expected tau decay rate while operating in different environments is noteworthy. A confirmation of these results would point to new particles or interactions and could have profound implications for the understanding of particle physics. "We're not sure what confirmation of these results will mean in the long term," Franco Sevilla said. | For purely leptonic B − decays, the standard model prediction of the total decay rate Γ, which depends critically on the lepton mass squared m ℓ 2 , is: One of the key assumptions of the standard model of particle physics is that the interactions of the charged leptons, namely electrons, muons and taus, differ only because of their different masses. A confirmation of these results would point to new particles or interactions, and could have profound implications for our understanding of particle physics. SM 0 05 0 10 4 Decays to the lower-mass charged leptons, e − and μ − , are strongly suppressed by spin effects and have not yet been observed. | [5] | Medicine | train | 5 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/VPxE-tYPN_o/ |
10.1001/jamasurg.2018.4608 | Medicine_easy_478 | "In urgent situations, patients need not be denied cardiac surgery because of their OUD status, although close postoperative monitoring is suggested," the authors write. | In urgent situations, patients need not be denied cardiac surgery because of their OUD status, although close postoperative monitoring is suggested. | They also had a significantly longer length of stay (median, 11 versus 10 days; P < 0.001) and higher cost per patient ($49,790 versus $45,216; P < 0.001). "In urgent situations, patients need not be denied cardiac surgery because of their OUD status, although close postoperative monitoring is suggested," the authors write. Abstract/Full Text (subscription or payment may be required) | In conclusion, preoperative OUD in cardiac surgery patients does not increase mortality but confers an increased burden of morbidity and resource utilization. Trends in patient volume and morbidity reported in our study suggest that cardiac surgeons are likely to encounter this population of patients more often now than in the past and should be prepared to adequately manage the perioperative factors specific to them. In urgent situations, patients need not be denied cardiac surgery because of their OUD status, although close postoperative monitoring is suggested. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=38086062320&p=1pl&v=1&x=7OYx6eU_dmAY0OnM1eTLzg |
10.1016/j.juro.2016.08.007 | Medicine_easy_480 | "Men's level of emotional distress shortly after diagnosis predicted greater likelihood of choosing surgery over active surveillance," the researchers report. | The level of emotional distress in men shortly after diagnosis predicted a greater likelihood of choosing surgery over active surveillance. | The majority of study participants had either low- or intermediate-risk disease, and were more likely to have been treated with surgery, followed by radiation and active surveillance. "Men's level of emotional distress shortly after diagnosis predicted greater likelihood of choosing surgery over active surveillance," the researchers report. "Importantly, this was true among men with low-risk disease, for whom active surveillance may be a clinically viable option and side effects of surgery might be avoided." | Being older was associated with a lower likelihood of choosing surgery over active surveillance or radiation. The level of emotional distress in men shortly after diagnosis predicted a greater likelihood of choosing surgery over active surveillance. Importantly, this was true for men with low risk disease, for whom active surveillance may be a clinically viable option and the side effects of surgery or radiation might be unnecessary. | [5] | Medicine | train | 5 | news | http://www.futurity.org/prostate-cancer-anxiety-1333372-2/ |
10.1001/jama.2019.1432 | Medicine_easy_481 | The authors concluded: "In this long-term prospective cohort study, diet quality assessed during midlife was not significantly associated with subsequent risk for dementia." | In this long-term prospective cohort study, diet quality assessed during midlife was not significantly associated with subsequent risk for dementia. | Of the 8,255 total, 344 participants had developed dementia in the 25 years following the start of the study. The authors concluded: "In this long-term prospective cohort study, diet quality assessed during midlife was not significantly associated with subsequent risk for dementia." "This was a robust study that followed participants over a long time, but was based on self-reported feedback from the participants on their diet, which may not always be accurate. | Fourth, as with all observational studies, it was not possible to rule out residual confounding. In this long-term prospective cohort study, diet quality assessed during midlife was not significantly associated with subsequent risk for dementia. The validity and reliability of this version of the FFQ in terms of nutrient and food consumption has been documented in detail both in this cohort and in another independent study in the United Kingdom. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=38752330367&p=1pl&v=1&x=xgPuP-sFG5bg4SZUexf-TA |
10.1093/jnci/dju237 | Medicine_easy_483 | "Promotion of lactation may be an effective tool for reducing occurrence of the subtypes that contribute disproportionately to breast cancer mortality," concluded the authors. | Promotion of lactation may be an effective tool for reducing occurrence of the subtypes that contribute disproportionately to breast cancer mortality. | The risk of ER-negative breast cancer increased with each subsequent birth among those women who did not breastfeed (odds ratio of 1.68 for four or more births compared with one birth for a woman who breastfed). "Promotion of lactation may be an effective tool for reducing occurrence of the subtypes that contribute disproportionately to breast cancer mortality," concluded the authors. The finding may explain why African American women, who typically have more children but have lower rates of breastfeeding compared with American white women, are disproportionately affected by ER-negative breast cancer, stated the authors. | The findings suggest that parous women who have not breastfed are at increased risk of ER-and triple-negative breast cancer. Promotion of lactation may be an effective tool for reducing occurrence of the subtypes that contribute disproportionately to breast cancer mortality. If so, the higher parity and lower prevalence of lactation in AA women relative to white women could be a contributor to the racial disparity in ER-cancer. | [5] | Medicine | train | 5 | news | http://www.cancernetwork.com/triple-negative-breast-cancer/breastfeeding-reduces-breast-cancer-risk-black-women |
10.1016/j.jtho.2016.01.011 | Medicine_easy_484 | "This paper validates H-NMR metabolic phenotyping of blood plasma as a complementary tool to discriminate between lung cancer patients and controls," stated the authors. | In conclusion, this paper validates 1 H-NMR metabolic phenotyping of blood plasma as a complementary tool to discriminate between patients with lung cancer and controls. | The model had a sensitivity of 71% and a specificity of 81%; however, it could not discriminate between histologic subtypes and tumor stages. "This paper validates H-NMR metabolic phenotyping of blood plasma as a complementary tool to discriminate between lung cancer patients and controls," stated the authors. "Our findings indicate that while metabolic alterations can be detected at an early stage, our intent is not to use the metabolome as a separate screening tool but to complement current risk models with additional parameters to better select high-risk individuals eligible for LDCT screening." | These findings indicate that lung cancer cells utilize at least some steps of the gluconeogenic pathway to adapt to low-glucose conditions as a result of insufficient blood flow. In conclusion, this paper validates 1 H-NMR metabolic phenotyping of blood plasma as a complementary tool to discriminate between patients with lung cancer and controls. Our findings indicate that metabolic alterations can already be detected in an early stage. | [5] | Medicine | train | 5 | news | http://www.oncologynurseadvisor.com/unique-metabolic-biomarkers-specific-to-lung-cancer-found/article/482912/ |
10.1038/s41586-018-0150-y | Medicine_easy_485 | What happened next astonished them. | v, GBX2 is expressed in the host and in the graft-induced secondary axis. | There is a difference between what cells can do in a Petri dish, however, and what they will do inside a real embryo. What happened next astonished them. Yet as soon as they were introduced to their avian hosts, the human cells began laying the groundwork for a secondary spinal column and nervous system--an act that clearly announced the presence of a true human organizer. | u, HOXB1 is expressed in the host and in the graft-induced secondary axis. v, GBX2 is expressed in the host and in the graft-induced secondary axis. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. | [1] | Medicine | train | 1 | news | https://www.futurity.org/stem-cells-embryos-1771882-2/ |
10.1038/s41598-017-18681-4 | Medicine_easy_486 | En net als ieder ander middel zijn ze niet onfeilbaar. | Another point to be noted is the following: Here, the interaction parameter is chosen as Q = γρ dm ρ de . | Misschien dat digitale computers en modellen weliswaar handige middelen zijn om de wereld beter te begrijpen, maar ook weer niet veel meer dan dat. En net als ieder ander middel zijn ze niet onfeilbaar. We moeten er rekening mee blijven houden dat ze er net zo goed naast kunnen zitten. | In fact this model establishes lower and upper boundaries for the EoS parameters of dark energy. Another point to be noted is the following: Here, the interaction parameter is chosen as Q = γρ dm ρ de . This implies that the transformation between dark energy and dark matter will be equal for both directions. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=40290578371&p=1pl&v=1&x=qYzyuuN_ge5s0bCN6R9APA |
10.4049/jimmunol.1502483 | Medicine_easy_487 | "If we can instead vaccinate mom or boost her vaccination shortly before she becomes pregnant, transferred immune cells during breast feeding will ensure that the baby is protected early on. | This mechanism is consistent with the observation that a significant proportion of transferred maternal cells: 1) had a memory phenotype; 2) were Ag-specific by tetramer staining; or 3) when in the spleen, responded to Ag by the production of appropriate cytokines. | The researchers show that you can vaccinate the mother and this results in vaccination of the baby through this process. "If we can instead vaccinate mom or boost her vaccination shortly before she becomes pregnant, transferred immune cells during breast feeding will ensure that the baby is protected early on. "We hope that by vaccinating the mother, who will eventually nurse the baby, we will improve infant immunity against TB," Walker said. | The mechanisms by which CD4 + T cells can acquire MHCII seem to be fewer in mice than humans . This mechanism is consistent with the observation that a significant proportion of transferred maternal cells: 1) had a memory phenotype; 2) were Ag-specific by tetramer staining; or 3) when in the spleen, responded to Ag by the production of appropriate cytokines. Importantly, Umeshappa et al. | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/lnaDDxms29c/ |
10.1016/j.neuropharm.2018.11.016 | Medicine_easy_488 | Esto se conoce como extincion del miedo. | S7A ) and the IL (interaction THC x stress: F 1,22 = 5.66, p < 0.05) (Fig. | Normalmente, las reacciones de miedo disminuyen con el tiempo a medida que el estimulo deja de asociarse con la experiencia negativa. Esto se conoce como extincion del miedo. "Hemos observado que ratones adolescentes tratados con THC y expuestos al estres exhiben un deterioro en la extincion del miedo en la edad adulta. | Simultaneous THC and stress adolescent exposure reduced the activity of the BLA (interaction THC x stress: F 1,23 = 9.52, p < 0.05) (Fig. S7A ) and the IL (interaction THC x stress: F 1,22 = 5.66, p < 0.05) (Fig. Interestingly, cFos expression was higher in adult animals exposed to THC and stress during the adolescence that did not undergo fear conditioning/extinction in both the BLA (p < 0.05) (Fig. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38133740347&p=1pl&v=1&x=f5RA8MMV5XZmwk4nj7ktlg |
10.1038/s41467-018-08119-4 | Medicine_easy_489 | Flipping the quantum switch
Using this system, researchers can literally turn spin-orbit coupling on and off, which allows them to isolate its effect on spin current decay. | In addition, all the effective interaction parameters would approach the corresponding bare values, i.e., g ↑ ↑ → g ↑↑ , g ↓ ↓ → g ↓↓ , and g ↑ ↓ → g ↑↓ . | "Because we can control every parameter, this is a really efficient system to study these kinds of collisions." Flipping the quantum switch
Using this system, researchers can literally turn spin-orbit coupling on and off, which allows them to isolate its effect on spin current decay. This can't be done with electrons in solid-state materials, which is part of what makes this system so powerful, Chen says. | As we can see, either decreasing Ω or increasing q y would decrease θ qy (or increase cos θ qy ). In addition, all the effective interaction parameters would approach the corresponding bare values, i.e., g ↑ ↑ → g ↑↑ , g ↓ ↓ → g ↓↓ , and g ↑ ↓ → g ↑↓ . On the other hand, either increasing Ω or decreasing q y would increase θ qy towards π/2 (or decrease cos θ qy ), thus enhancing the bare spin mixing, nonorthogonality and g ↑ ↓ . | [1] | Medicine | train | 1 | news | https://www.futurity.org/quantum-system-for-spintronics-1972642/ |
10.1038/s41598-017-00678-8 | Medicine_easy_491 | It seemed to increase students' level of physical, mental and emotional awareness. | The shortest path length L ij between node i and j is the length of the path with the shortest length between the 2 nodes. | Meditation allowed them to know themselves better, helping them feel more relaxed and peaceful. It seemed to increase students' level of physical, mental and emotional awareness. Moreover, students also reported waking dreams, visions and a sense of tranquility during meditation. | The global efficiency of G can be computed as: The shortest path length L ij between node i and j is the length of the path with the shortest length between the 2 nodes. Shortest path length. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33999175752&p=1pl&v=1&x=8DSh2p-NEYJL7vSaxYifuA |
10.1001/jamainternmed.2017.5038 | Medicine_easy_492 | There's bound to be a lot of hand-wringing over this in certain corners of the internet. | Similar trends were observed with greater intake of low-pesticide residue FVs except that no difference in prevalence of diminished ovarian reserve was observed. | It seems that eating fruits and vegetables that are known to have high pesticide residues could make it harder to get pregnant. There's bound to be a lot of hand-wringing over this in certain corners of the internet. So, I want to put these findings in perspective for those of you who are trying to conceive as well as anyone who is just generally concerned about pesticides and their effects on health. | Women who consumed more high-pesticide residue FVs were more likely to report regular organic FV consumption, had higher total calorie and micronutrient intake, higher adherence to the prudent dietary pattern, and a slightly higher prevalence of diminished ovarian reserve. Similar trends were observed with greater intake of low-pesticide residue FVs except that no difference in prevalence of diminished ovarian reserve was observed. Other characteristics were similar across quartiles of high-or low-pesticide FV intake ( Table 2) . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33322911082&p=1pl&v=1&x=r2UbM3QJAND2ZMUx0DoPKQ |
10.1073/pnas.1514699113 | Medicine_easy_493 | If shame is a defense against devaluation, then the intensity of shame associated with an act should move up or down in lockstep with the degree to which others in your community would devalue you (if they knew your behavior). | Yes (see Table 1 , diagonal values). | Depending on the aversive magnitude of the anticipated shame, individuals will often be deterred from behaviors that hurt or destroy their relationships with the people around them -- or they will be motivated to hide them. If shame is a defense against devaluation, then the intensity of shame associated with an act should move up or down in lockstep with the degree to which others in your community would devalue you (if they knew your behavior). "We observed a surprisingly close match between the negative reactions to people who commit each of these acts -- that is, the magnitudes of devaluation -- and the intensities of shame felt by individuals imagining that they would commit those acts," Cosmides said. | 3. Yes (see Table 1 , diagonal values). Shame and devaluation means were highly correlated with one another in each country, with a mean r of .72 and a range of rs of .67-.79. | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/8ZfHYeQdk9w/ |
10.1126/science.aat3466 | Medicine_easy_495 | They found that rising global temperatures would lead to an increase in crop losses from insects, especially in temperate regions. | As a result, the increase in pest-related crop loss is consistently larger than in tropical regions, where the increasing metabolic rate is offset by declining population growth rates, resulting in a smaller overall rise in crop damages. | "We are going to see increased pest pressure from climate change." They found that rising global temperatures would lead to an increase in crop losses from insects, especially in temperate regions. Losses are projected to rise by 10 to 25% per degree of warming. | In temperate regions, warming increases both the size of insect populations and their per capita metabolic rate (Fig. As a result, the increase in pest-related crop loss is consistently larger than in tropical regions, where the increasing metabolic rate is offset by declining population growth rates, resulting in a smaller overall rise in crop damages. This broad geographic pattern holds across all crops, climate models, and life history parameters considered ( Fig. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34960791264&p=1pl&v=1&x=xXKZ8HOVq-LOHSdbqTvAUg |
10.1016/j.cell.2017.07.013 | Medicine_easy_497 | "Initially, we did not expect the outcome would come out this way," Tonegawa says. | The AAV 9 -EF1a-DIO-mCherry, AAV 9 -EF1a-DIO-eArch3.0-mCherry, and AAV 9 -EF1a-eArch3.0-eYFP viruses were acquired from Vector BioLabs. | Other experiments revealed that the direct circuit from CA1 to the entorhinal cortex is not necessary for memory recall, but is required for memory formation. "Initially, we did not expect the outcome would come out this way," Tonegawa says. The researchers found evidence for two possible explanations. | The AAV 9 -EF1a-DIO-eYFP, AAV 9 -EF1a-DIO-ChR2-eYFP, and AAV 9 -EF1a-DIO-eArch3.0-eYFP viruses were acquired from the University of North Carolina (UNC) at Chapel Hill Vector Core. The AAV 9 -EF1a-DIO-mCherry, AAV 9 -EF1a-DIO-eArch3.0-mCherry, and AAV 9 -EF1a-eArch3.0-eYFP viruses were acquired from Vector BioLabs. Viral titers were 1.2 3 10 13 genome copy (GC) mL -1 for AAV 9 -EF1a-DIO-eYFP, 4 3 10 12 GC mL -1 for AAV 9 -EF1a-DIO-ChR2-eYFP, 1.6 3 10 13 GC mL -1 for AAV 9 -EF1a-DIO-eArch3.0-eYFP, 3 3 10 13 GC mL -1 for AAV 9 -EF1a-DIO-mCherry and AAV 9 -EF1a-DIO-eArch3.0-mCherry, 1 3 10 11 GC mL -1 for AAV 9 -EF1a-eArch3.0-eYFP, 4 3 10 12 GC mL -1 for AAV 2 -Syn-DIO-GCaMP6f and AAV 5 -Syn-DIO-GCaMP6f, 1.1 3 10 13 GC mL -1 for AAV 8 -CMV-DIO-Synaptophysin-mCherry, 2 3 10 14 GC mL -1 for AAV 9 -EF1a-DIO-H2B-GFP, 4 3 10 13 GC mL -1 for AAV 9 -c-Fos-tTA, 1.4 3 10 13 GC mL -1 for AAV 5 -TRE-H2B-GFP, and 1.5 3 10 13 GC mL -1 for AAV 9 -TRE-ChR2-eYFP. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/how-we-recall-the-past-neuroscientists-discover-a-brain-circuit-dedicated-to-retrieving-memories/ |
10.1016/j.cell.2013.05.002 | Medicine_easy_498 | These tests largely stopped with the Limited Test Ban Treaty of 1963, but their effects remained in the atmosphere. | Analysis of the number of neuronal progenitor cells gives an indirect indication of the possible extent of neurogenesis. | The oldest person in the study was 72, suggesting new neuron creation, known as neurogenesis, continues well into old age. These tests largely stopped with the Limited Test Ban Treaty of 1963, but their effects remained in the atmosphere. The neutrons sent flying by the bombs reacted with nitrogen in the atmosphere, creating a spike in carbon 14, an isotope (or variation) of carbon. | The similar decline in neuroblast numbers in the subventricular zone and the hippocampus poses the question of whether there is postnatal hippocampal neurogenesis in humans to an extent that may have an impact on brain function. Analysis of the number of neuronal progenitor cells gives an indirect indication of the possible extent of neurogenesis. The cumulative nature of 14 C integration makes the method especially suited for establishing the kinetics of slowly turning over cell populations. | [1] | Medicine | train | 1 | news | http://www.livescience.com/37226-bomb-tests-reveal-new-neurons.html |
10.1016/j.neuron.2014.01.025 | Medicine_easy_499 | "As an engineer, I can't design a circuit that would do that," Stanley said. | Taken together, the spiking activity measured in the VPm thalamus of the awake animal strongly mirrored the behavioral findings obtained throughout the study. | But in the brain, a pathway adaptively changes between being good at detecting something to being good at discriminating something, the study showed. "As an engineer, I can't design a circuit that would do that," Stanley said. Learning more about how circuits in the brain multitask could lead to a better understanding of disease, therapeutic applications or to potentially improving how the brain functions. | Similarly, timing precision as measured using TC40 was reduced to 81% ± 3.0% of the nonadapted value with a short period of recovery (p < 0.005, n = 43, paired t test) and increased to 87% ± 3.0% of its nonadapted value (p < 0.05, n = 43, paired t test) with additional recovery time (Figure 6D) . Taken together, the spiking activity measured in the VPm thalamus of the awake animal strongly mirrored the behavioral findings obtained throughout the study. The Spatial Discrimination Performance of the Animals Is Improved with Adaptation (A) Discrimination task. | [1] | Medicine | train | 1 | news | http://www.newswise.com/articles/brain-circuits-multitask-to-detect-discriminate-the-outside-world |
10.1098/rspb.1998.0302 | Medicine_easy_500 | Males and females, they found, oftentimes both began from the same brightly colored starting point. | Ellipsoid models are valid if the thresholds are small compared to nonlinearities in signal processing, or when discrimination is limited by noise in receptors and in opponency channels. | This allowed them to standardize and compare colors between the sexes and within and between bird species according to how birds perceive color rather than how people see it. Males and females, they found, oftentimes both began from the same brightly colored starting point. But the females' rate of evolutionary change tended to outpace their male counterparts, allowing the fairer sex of many species to, well, lose their "fairness" and quickly shed their color, while males evolved at a slower step toward more gaudy patterns. | Models which describe sensitivity to small di¡erences by ellipsoids of colour mismatches are useful for predicting contours of equal discriminability in a perceptual space . Ellipsoid models are valid if the thresholds are small compared to nonlinearities in signal processing, or when discrimination is limited by noise in receptors and in opponency channels. the number of parameters exceeds the number of receptor types. | [1] | Medicine | train | 1 | news | http://www.smithsonianmag.com/science-nature/drab-female-birds-were-once-flashy-their-male-mates-180951427/ |
10.3109/15563650.2015.1110590 | Medicine_easy_501 | In this way, the more adverse effects observed with synthetic cannabis use stem from its ability to completely saturate and activate all of the body's cannabinoid receptors at a lower dose. | 58 Hospitalization lasted between 6-10 days and in one case, symptoms persisted for more than five months. | This is because, while the THC in natural cannabis only partially reacts with the body, synthetic cannabis reacts far more fully. In this way, the more adverse effects observed with synthetic cannabis use stem from its ability to completely saturate and activate all of the body's cannabinoid receptors at a lower dose. Different brands of smoking mixtures can have very different effects, but the strength of a specific brand appears to owe more to the ratio of cannabinoids to chemically inactive plant material in the mixture, rather than the variation in the chemical structure of compounds themselves. | Hurst et al reported on 10 cases of new onset psychosis associated with SC use from San Diego, although only two involved just the use of SCs, with the remainder consuming cannabis or alcohol either concurrently or in the recent past. 58 Hospitalization lasted between 6-10 days and in one case, symptoms persisted for more than five months. An audit of an open adult ward in New Zealand found 13% (n=17) of psychiatric admissions were probably related to SC consumption, including four first time admissions (affective, suicidal or psychotic symptoms) plus four first admissions with psychosis. | [1] | Medicine | train | 1 | news | http://www.theepochtimes.com/n3/2169878-what-is-spice-and-why-is-the-drug-so-dangerous/ |
10.1186/1471-2105-15-328 | Medicine_easy_502 | With a little help from a team of engineers at Drexel University, these scientists could soon be donning 3-D glasses in a home-theater-like lab to take their own fantastic voyage into the petri dish. | The delta for each node connected to this root node is based only on the registration position change. | With a little help from a team of engineers at Drexel University, these scientists could soon be donning 3-D glasses in a home-theater-like lab to take their own fantastic voyage into the petri dish. "This type of imaging is so important because it allows us to see and measure relationships between cells and their environment," Cohen said. LEVER is easier and more accurate than processing the data manually and also provides more data than what can be obtained by hand. | This technique also works directly on the images rather than requiring preprocessing to determine a set of feature points that are used in more complex registration schemes. The delta for each node connected to this root node is based only on the registration position change. The final positions can be viewed as the red lines in Figure 2 . | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2014/10/141003214351.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |