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10.1016/j.jsams.2019.05.003 | Medicine_easy_6 | "While for the majority of cancer patients, moderate to high intensity exercise will likely be appropriate, there is no set prescription and total weekly dosage that would be considered evidence-based for all cancer patients." | Conclusions: While for the majority, multimodal, moderate to high intensity exercise will be appropriate, there is no set prescription and total weekly dosage that would be considered evidence-based for all cancer patients. | "Research in this space has exponentially grown and consequently, the updated position stand now provides the foundation for Accredited Exercise Physiologists to ensure their exercise prescription is targeted towards improving cancer outcomes," Professor Hayes said. "While for the majority of cancer patients, moderate to high intensity exercise will likely be appropriate, there is no set prescription and total weekly dosage that would be considered evidence-based for all cancer patients." This position statement allows for precision medicine through exercise." | Additional specific exercise prescription considerations are provided for the presence of haematological, musculoskeletal, systemic, cardiovascular, lymphatic, gastrointestinal, genitourinary and neurological disease-and treatment-related concerns, as well as presence of co-morbid chronic disease. Conclusions: While for the majority, multimodal, moderate to high intensity exercise will be appropriate, there is no set prescription and total weekly dosage that would be considered evidence-based for all cancer patients. Targeted exercise prescription, which includes the provision of behaviour change advice and support, is needed to ensure greatest benefit (as defined by the patient) in the short and longer term, with low risk of harm. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=39294284554&p=1pl&v=1&x=LXJKTkEMj4CRRK0Y-kPbZw |
10.1377/hlthaff.2012.1030 | Medicine_easy_7 | "Because Medicaid pays for nearly half of U.S. births, government efforts to decrease variation are warranted." | Because Medicaid pays for nearly half of US births, government efforts to decrease variation are warranted. | Even among lower-risk pregnancies, "in which more limited variation might be expected," hospital cesarean rates varied 15-fold, from 2 percent to 37 percent. "Because Medicaid pays for nearly half of U.S. births, government efforts to decrease variation are warranted." Read this story on www.medpagetoday.com. | Thus, vast differences in practice patterns are likely to be driving the costly overuse of cesarean delivery in many US hospitals. Because Medicaid pays for nearly half of US births, government efforts to decrease variation are warranted. We focus on four promising directions for reducing these variations, including better coordinating maternity care, collecting and measuring more data, tying Medicaid payment to quality improvement, and enhancing patient-centered decision making through public reporting. | [5] | Medicine | train | 5 | news | http://abcnews.go.com/Health/section-rates-vary-widely-hospitals-study-finds/story?id=18656847 |
10.1111/cdev.12250 | Medicine_easy_8 | The pseudomature behaviors evolved into larger problems and the status of once cool individuals dropped: "The adolescent who comes to depend upon pseudomature behavior to gain peer status may gradually need to shift, for example, from minor forms of delinquency, such as vandalism and shoplifting, to more serious acts of criminal behavior to impress even a subset of older peers," the authors wrote. | The adolescent who comes to depend upon pseudomature behavior to gain peer status may gradually need to shift, for example, from minor forms of delinquency, such as vandalism and shoplifting, to more serious acts of criminal behavior to impress even a subset of older peers. | In fact, just the opposite happened. The pseudomature behaviors evolved into larger problems and the status of once cool individuals dropped: "The adolescent who comes to depend upon pseudomature behavior to gain peer status may gradually need to shift, for example, from minor forms of delinquency, such as vandalism and shoplifting, to more serious acts of criminal behavior to impress even a subset of older peers," the authors wrote. The chart below shows that students who engaged in pseudomature behavior at 13 were perceived as more popular by their peers than those who did not engage in pseudomature behavior, but that correlation faded over time. | Early reliance upon minor acts of delinquency to impress peers may thus lead to a greater likelihood of associating with deviance-prone peers, who in turn would only be impressed by more and more serious acts of deviance over time. The adolescent who comes to depend upon pseudomature behavior to gain peer status may gradually need to shift, for example, from minor forms of delinquency, such as vandalism and shoplifting, to more serious acts of criminal behavior to impress even a subset of older peers. Similarly, whereas minor levels of alcohol or substance use may impress a subgroup of peers in early adolescence, by early adulthood, such behavior would gain little notice, and it may take heavy drinking and more serious substance use to try to impress adult peers. | [5] | Medicine | train | 5 | news | http://www.businessinsider.com/being-popular-in-high-school-leads-to-problems-in-adulthood-2014-6 |
10.1542/peds.2017-1330 | Medicine_easy_9 | "Marijuana users who use other drugs are at highest risk for currently using SCs, so particular focus must be paid to these individuals to prevent increasingly dangerous and severe health outcomes among young users." | Marijuana users who use other drugs in particular are at highest risk for currently using SCs, so particular focus needs to be paid to these individuals at high risk. | Although previous studies have revealed that marijuana users are at high risk for SC use, this study further revealed risk factors among current marijuana users that increase risk of current use and higher-frequency use of SCs. "Our research calls for future prevention focused primarily on marijuana users, especially male and/or African-American marijuana users who appear to be at greatest risk for frequent use," says Palamar. "Marijuana users who use other drugs are at highest risk for currently using SCs, so particular focus must be paid to these individuals to prevent increasingly dangerous and severe health outcomes among young users." | Although previous studies have revealed that marijuana users are at high risk for use, this study revealed risk factors among current marijuana users that increase risk of current use and higher-frequency use of SCs. Prevention needs to be focused primarily on marijuana users, especially marijuana users with risk factors discovered in this analysis. Marijuana users who use other drugs in particular are at highest risk for currently using SCs, so particular focus needs to be paid to these individuals at high risk. | [5] | Medicine | train | 5 | news | http://www.futurity.org/synthetic-cannabinoids-spice-1549022-2/ |
10.1001/jama.2014.15690 | Medicine_easy_10 | Reduction in the incidence of colorectal cancer may influence the overall benefitrisk profile of aspirin. | Reduction in the incidence of colorectal cancer may influence the overall benefit-risk profile of aspirin. | The authors write that despite inconsistent evidence for the benefit of aspirin in primary prevention of cardiovascular events, the benefits in secondary prevention are well documented, including in Japanese patients. Reduction in the incidence of colorectal cancer may influence the overall benefitrisk profile of aspirin. Further analyses of [this] study data are planned, including analysis of deaths associated with cancers, to allow more precise identification of the patients for whom aspirin treatment may be most beneficial. | No effect on fatal myocardial infarction was observed, but a modest nonsignificant reduction was apparent for all-cause mortality. Reduction in the incidence of colorectal cancer may influence the overall benefit-risk profile of aspirin. Further analyses of the JPPP study data are planned, including analysis of deaths associated with cancers, to allow more precise identification of the patients for whom aspirin treatment may be most beneficial. | [5] | Medicine | train | 5 | news | http://www.newswise.com/articles/effect-of-once-daily-low-dose-aspirin-on-cv-death-and-other-outcomes |
10.1377/hlthaff.2012.1030 | Medicine_easy_11 | Cesarean rates increased from 20.7 percent in 1996 to 32.8 percent in 2011, according to the Minnesota researchers. | Cesarean rates increased from 20.7 percent of all deliveries in 1996 to 32.8 percent in 2011. | "The scale of this variation signals potential quality issues that should be quite alarming to women, clinicians, hospitals and policymakers," she added.Cesarean delivery is the most common surgery in the United States, performed on 1.67 million women each year. Cesarean rates increased from 20.7 percent in 1996 to 32.8 percent in 2011, according to the Minnesota researchers. "Cesarean deliveries save lives, and every woman who needs one should have one," Kozhimannil said. | We focus on four promising directions for reducing these variations, including better coordinating maternity care, collecting and measuring more data, tying Medicaid payment to quality improvement, and enhancing patient-centered decision making through public reporting. Cesarean rates increased from 20.7 percent of all deliveries in 1996 to 32.8 percent in 2011. 3 In international comparisons, US cesarean rates exceed those for similar countries, without measurable clinical benefit. | [5] | Medicine | train | 5 | news | http://www.webmd.com/baby/news/20130304/c-section-rates-vary-widely-at-us-hospitals |
10.1001/jamasurg.2018.0672 | Medicine_easy_12 | The difference in the global score of SwQoR between inadequate and sufficient FHL (37.4 and 17.7) was statistically significant. | There was a statistically significant difference in the global score of SwQoR (SD) between inadequate (37.4 [34.7]) and sufficient FHL (17.7 [21.0]) (P < .001). | The researchers found that the inadequate and problematic FHL groups had a global score of SwQoR that indicated poor recovery (37.4 and 22.9, respectively). The difference in the global score of SwQoR between inadequate and sufficient FHL (37.4 and 17.7) was statistically significant. Compared to patients with sufficient FHL, patients with inadequate or problematic FHL had a lower health-related quality of life in terms of EuroQoL-visual analog scale scores, physical function, bodily pain, vitality, social functioning, mental health, and physical component summary. | The global score of SwQoR indicated poor recovery in both inadequate (37.4) and problematic (22.9) FHL. There was a statistically significant difference in the global score of SwQoR (SD) between inadequate (37.4 [34.7]) and sufficient FHL (17.7 [21.0]) (P < .001). The patients with inadequate or problematic FHL had a lower health-related quality of life than the patients with sufficient FHL in terms of EuroQol-visual [11.3], and 45 [10.1], respectively; P = .004). | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33900191633&p=1pl&v=1&x=U2NKEgQRLXmLRbYHpHEUVQ |
10.1377/hlthaff.2018.05101 | Medicine_easy_13 | "Policies that incentivize providers to adopt telehealth could be an important way to increase access for underserved populations." | Policies that incentivize providers and health systems to use telehealth could be an important way to increase access to care for underserved populations. | But underserved populations -- such as low-income, rural and Medicaid populations -- did not use video-based telehealth as widely as other demographic groups. The researchers identified this trend across the U.S., even in states with less restrictive telehealth policies -- suggesting that providers and patients will need incentives to adopt the service that go beyond removing regulatory restrictions. "Policies that incentivize providers to adopt telehealth could be an important way to increase access for underserved populations." | Making telehealth easy to use is important but might not be enough to make providers or health systems invest the time, energy, and money needed to begin offering the service or expand its use. Policies that incentivize providers and health systems to use telehealth could be an important way to increase access to care for underserved populations. For example, offering financial incentives for providers to adopt telehealth may lead to increased usage, as payment incentives led to the increased adoption and use of electronic health records and patient-centered medical home status in safety-net clinics. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37884913467&p=1pl&v=1&x=MrQLspWtUsUM_TYVPtFo1w |
10.1016/j.jsams.2019.05.003 | Medicine_easy_14 | "While for the majority of cancer patients, moderate to high intensity exercise will likely be appropriate, there is no set prescription and total weekly dosage that would be considered evidence-based for all cancer patients." | While for the majority, multimodal, moderate to high intensity exercise will be appropriate, there is no set prescription and total weekly dosage that would be considered evidence-based for all cancer patients. | "Research in this space has exponentially grown and consequently, the updated position stand now provides the foundation for Accredited Exercise Physiologists to ensure their exercise prescription is targeted towards improving cancer outcomes," Professor Hayes said. "While for the majority of cancer patients, moderate to high intensity exercise will likely be appropriate, there is no set prescription and total weekly dosage that would be considered evidence-based for all cancer patients." This position statement allows for precision medicine through exercise." | Overall, evidence supports that the implementation of exercise prescription brings with it reduced morbidity, improved function and quality of life, and potential for improved survival, with very low risk of harm. While for the majority, multimodal, moderate to high intensity exercise will be appropriate, there is no set prescription and total weekly dosage that would be considered evidence-based for all cancer patients. Appropriate exercise prescription for cancer patients needs to be targeted and individualised according to patient-and cancer-specific considerations. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=39294284554&p=1pl&v=1&x=LXJKTkEMj4CRRK0Y-kPbZw |
10.1038/nature13850 | Medicine_easy_15 | According to the study, "the unexpected morphology suggests that the magnetic field's role during the accretion of a T Tauri star is more complex than the current theoretical understanding," and that magnetic fields are important in forming a planetary system like our own. | The unexpected morphology suggests that the role of the magnetic field in the accretion of a T Tauri star is more complex than our current theoretical understanding. | These CARMA observations found the first detection of the magnetic field morphology in a T Tauri star disk. According to the study, "the unexpected morphology suggests that the magnetic field's role during the accretion of a T Tauri star is more complex than the current theoretical understanding," and that magnetic fields are important in forming a planetary system like our own. While the magnetic field morphology appears significantly more toroidal than poloidal, neither morphology is a good fit. | From this we conclude that the magnetic field inside the disk at this scale cannot be dominated by a vertical component, though a purely toroidal field also does not fit the data well. The unexpected morphology suggests that the role of the magnetic field in the accretion of a T Tauri star is more complex than our current theoretical understanding. Although HL Tau is a T Tauri star, it is considered to be in an early stage of development owing to its bipolar outflow 14 and possible residual envelope 15 . | [5] | Medicine | train | 5 | news | http://www.futurity.org/stars-magnetic-field-803342/ |
10.1080/02770903.2017.1299757 | Medicine_easy_16 | A total of 799 children in 24 schools completed the questionnaire and 689 were included for analysis. | Results: A total of 799 children completed the questionnaire; 689 (86.2%) were included for analysis. | The researchers say the results should prompt more intense clinical monitoring, and suggest a need for interventions aimed at addressing poor asthma control in UK schoolchildren. A total of 799 children in 24 schools completed the questionnaire and 689 were included for analysis. The study, published in the Journal of Asthma, found that suboptimal asthma control was reported by 49.6 per cent of the students. | Results: A total of 799 children completed the questionnaire; 689 (86.2%) were included for analysis. Suboptimal asthma control was reported by 49.6% of students. Over a third (42.4%) of students prescribed a short-acting β2-agonist inhaler felt uncomfortable using it at school, and 29.2% (n = 173) reported not using this inhaler when wheezy. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/asthmatic-schoolchildren-are-uncomfortable-using-their-inhalers/ |
10.1007/s10803-017-3154-9 | Medicine_easy_17 | "In spite of its limitations," the study authors concluded, "the present findings reveal indicators that may be useful for identifying children and adolescents at greater risk of psychiatric hospitalization as well as other potential targets for individual and family intervention." | In spite of its limitations, the present findings reveal indicators that may be useful for identifying children and adolescents at greater risk of psychiatric hospitalization as well as offer potential targets for individual and family intervention aimed at reducing the likelihood of requiring acute psychiatric services. | Also, the study measured associations of risk factors with hospitalization but doesn't prove they were the cause of hospital visits. But the study authors wrote that the risk factors they identified may be worth addressing before young autism patients reach the point where hospitalization becomes necessary. "In spite of its limitations," the study authors concluded, "the present findings reveal indicators that may be useful for identifying children and adolescents at greater risk of psychiatric hospitalization as well as other potential targets for individual and family intervention." | Lastly, there may be a variety of factors not measured in the present study that contribute to greater risk for hospitalization including outpatient psychiatric care, home-based behavioral services, school setting or day programming, and the availability of other individual and family services. In spite of its limitations, the present findings reveal indicators that may be useful for identifying children and adolescents at greater risk of psychiatric hospitalization as well as offer potential targets for individual and family intervention aimed at reducing the likelihood of requiring acute psychiatric services. Our results underscore the importance of a multi-disciplinary approach to the assessment and treatment of children and adolescents with ASD that addresses behavioral, psychological/ psychiatric, adaptive, sleep, and medical functioning in order to decrease behavioral crises and the utilization of inpatient psychiatric services. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/study-of-kids-with-autism-identifies-hospitalization-risk-factors/ |
10.1016/j.jsams.2019.05.003 | Medicine_easy_19 | "As exercise capacity improves, progression towards longer sessions of at least 20 minutes duration on most days of the week is recommended." | As exercise capacity improves, progression towards longer sessions of at least 20 min duration on most days of the week is recommended. | "The type, duration, frequency, intensity and total volume of exercise prescription needs to be tailored to the patient's needs and priorities," Professor Galvao said. "For example, for patients with a low level of fitness, or those with advanced stage disease, a starting exercise prescription may need to involve multiple short bouts of five to ten minutes, to accumulate at least 20 minutes on any given day. "As exercise capacity improves, progression towards longer sessions of at least 20 minutes duration on most days of the week is recommended." | For deconditioned patients, immediately post-surgery and/or for those with advanced stage disease, a starting exercise prescription may need to involve multiple short bouts (5-10 min duration) daily, to accumulate at least 20 min on any given day. As exercise capacity improves, progression towards longer sessions of at least 20 min duration on most days of the week is recommended. The 20 min cut-point being proposed (which has also been suggested by others previously ) is not distinct and less duration per day may be more optimal for some patients (e.g., palliative patients with lung cancer). | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=39294284554&p=1pl&v=1&x=LXJKTkEMj4CRRK0Y-kPbZw |
10.1038/s41598-018-30980-y | Medicine_easy_21 | However, when memory was tested again following overnight sleep, the change in memory accuracy was greater if the child had napped the previous day. | However, when memory was probed again following overnight sleep, the change in memory accuracy was greater if the child napped the previous day. | Change in memory accuracy also did not differ when tested after a nap compared to the change in memory accuracy after an interval awake, they report. However, when memory was tested again following overnight sleep, the change in memory accuracy was greater if the child had napped the previous day. Further, Spencer and colleagues report, greater nap slow wave activity was associated with greater memory decay during the nap. | Change in memory accuracy also did not differ when probed after a nap compared to the change in memory accuracy after an interval awake. However, when memory was probed again following overnight sleep, the change in memory accuracy was greater if the child napped the previous day. Greater nap slow wave activity was associated with greater memory decay during the nap. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34884544095&p=1pl&v=1&x=ZTfu4WJpcprjoFwmcebiPw |
10.1038/s41467-018-07557-4 | Medicine_easy_22 | "Our results demonstrate that one-third of pan-Arctic infrastructure and 45 percent of the hydrocarbon extraction fields in the Russian Arctic are in regions where thaw-related ground instability can cause severe damage to the built environment. | Our results demonstrate that one-third of pan-Arctic infrastructure and 45% of the hydrocarbon extraction fields in the Russian Arctic are in regions where thaw-related ground instability can cause severe damage to the built environment. | "We show that nearly four million people and 70 percent of current infrastructure in the permafrost domain are in areas with high potential for thaw of near-surface permafrost," the team wrote. "Our results demonstrate that one-third of pan-Arctic infrastructure and 45 percent of the hydrocarbon extraction fields in the Russian Arctic are in regions where thaw-related ground instability can cause severe damage to the built environment. Alarmingly, these figures are not reduced substantially even if the climate change targets of the Paris Agreement are reached." | We show that nearly four million people and 70% of current infrastructure in the permafrost domain are in areas with high potential for thaw of near-surface permafrost. Our results demonstrate that one-third of pan-Arctic infrastructure and 45% of the hydrocarbon extraction fields in the Russian Arctic are in regions where thaw-related ground instability can cause severe damage to the built environment. Alarmingly, these figures are not reduced substantially even if the climate change targets of the Paris Agreement are reached. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37952048427&p=1pl&v=1&x=WVBbJHZ_CDGkehwcKPFvdQ |
10.1016/j.jadohealth.2015.02.018 | Medicine_easy_23 | Before college, 28 percent of the women said they had experienced attempted or completed rape. | Before entering college, 28% of women had experienced attempted or completed rape. | By the time they started their sophomore year, 11 percent of the women said they had been raped by force, and nearly 16 percent said they had been raped while incapacitated, either as a teen or in college. Before college, 28 percent of the women said they had experienced attempted or completed rape. The study highlights the need for a "trauma-informed approach" in college messaging that is sensitive to rape survivors, notes an editorial in the Journal of Adolescent Health. | In addition, this study provides temporal resolution unavailable in most previous reports. Before entering college, 28% of women had experienced attempted or completed rape. During their first year, one of six female students had experienced A/C IR or A/C FR. | [5] | Medicine | train | 5 | news | http://www.csmonitor.com/USA/Education/2015/0520/Preventing-college-rape-why-freshman-year-is-key-especially-for-past-victims |
10.1001/jama.2013.277165 | Medicine_easy_25 | "Otamixaban did not reduce ischemic events compared with UFH plus eptifibatide but increased bleeding among patients with NSTE-ACS and a planned invasive strategy. | Otamixaban did not reduce ischemic events compared with UFH plus eptifibatide but increased bleeding among patients with NSTE-ACS and a planned invasive strategy. | Study anticoagulant was discontinued because of bleeding in 242 patients (4.7 percent) in the otamixaban group and in 95 patients (1.7 percent) in the UFH-plus-eptifibatide group. "Otamixaban did not reduce ischemic events compared with UFH plus eptifibatide but increased bleeding among patients with NSTE-ACS and a planned invasive strategy. These findings do not support the use of otamixaban for patients with NSTE-ACS undergoing planned early percutaneous coronary intervention," the authors conclude. | Other regimens might have offered a different benefit-risk profile, 19, 26, 27 but because otamixaban did not display superior efficacy and did show worse safety, this point is moot. Otamixaban did not reduce ischemic events compared with UFH plus eptifibatide but increased bleeding among patients with NSTE-ACS and a planned invasive strategy. These findings do not support the use of otamixaban for patients with NSTE-ACS undergoing planned early percutaneous coronary intervention. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2013/09/130901153354.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1093/eurpub/cky178 | Medicine_easy_26 | "Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles," the authors wrote. | Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles. | That simple narrative isn't quite accurate anymore. "Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles," the authors wrote. "We estimated that each 1% reduction in real public health expenditure per-capita corresponded to a 0.5 percentage points reduction in MMR coverage." | Second, we added the German-speaking province of Bolzano However, none of the main results was qualitatively changed, although the coefficient estimates were slightly attenuated. Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles. We estimated that each 1% reduction in real public health expenditure per-capita corresponded to a 0.5 percentage points reduction in MMR coverage. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37159214862&p=1pl&v=1&x=CcPjjUifeL13VJ3H086Sjg |
10.1093/eurpub/cky178 | Medicine_easy_27 | "Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles," the authors write. | Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles. | On average, a 0.5 percentage point decline in MMR coverage corresponds to a 1% cut in spending. "Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles," the authors write. It will be important to monitor these developments, not only to inform policy in Italy but across Europe where many countries now face similar problems." | Second, we added the German-speaking province of Bolzano However, none of the main results was qualitatively changed, although the coefficient estimates were slightly attenuated. Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles. We estimated that each 1% reduction in real public health expenditure per-capita corresponded to a 0.5 percentage points reduction in MMR coverage. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37085206177&p=1pl&v=1&x=Z0WLlSNB6z5fzDN5rayk1A |
10.1016/j.mayocp.2014.07.004 | Medicine_easy_28 | "As far as we are aware, our study is the first prospective cohort study comparing prescription medication when offered with specialist behavioral support with prescription medication offered without such support. | As far as we are aware, our study is the first prospective cohort study comparing prescription medication when offered with specialist behavioral support with prescription medication offered without such support. | A combination of prescription medication along with limited behavioral support was also more effective than unaided quitting. "As far as we are aware, our study is the first prospective cohort study comparing prescription medication when offered with specialist behavioral support with prescription medication offered without such support. A major strength of our study is the use of a representative sample of the English population that was sufficiently large to detect an effect of specialist behavioral support despite its low prevalence," says Dr. Kotz. | Finally, our sample size was too small for comparing the differential effectiveness of different prescription medications. As far as we are aware, our study is the first prospective cohort study comparing prescription medication when offered with specialist behavioral support with prescription medication offered without such support. A major strength of our study is the use of a representative sample of the English population that was sufficiently large to detect an effect of specialist behavioral support despite its low prevalence. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2014/10/141008083514.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1038/s41598-018-30980-y | Medicine_easy_29 | Yet nap slow wave activity also predicted greater overnight improvement in memory. | Yet nap slow wave activity also predicted greater overnight improvement in memory. | Further, Spencer and colleagues report, greater nap slow wave activity was associated with greater memory decay during the nap. Yet nap slow wave activity also predicted greater overnight improvement in memory. Together, "these results suggest that sleep bouts can interact to benefit memory in early childhood," they conclude. | Greater nap slow wave activity was associated with greater memory decay during the nap. Yet nap slow wave activity also predicted greater overnight improvement in memory. These results suggest that sleep bouts can interact to benefit memory in early childhood. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34884544095&p=1pl&v=1&x=ZTfu4WJpcprjoFwmcebiPw |
10.1001/jamasurg.2018.0672 | Medicine_easy_30 | Researchers believe this is the first study that has examined whether there is an association between postoperative recovery and functional health literacy in patients undergoing day surgery. | To our knowledge, this is the first study that has examined whether there is any association between postoperative recovery and functional health literacy in patients undergoing day surgery. | "Patients are spending less time in the hospital, and this places greater demands on the patients and their relatives. Researchers believe this is the first study that has examined whether there is an association between postoperative recovery and functional health literacy in patients undergoing day surgery. In the study, 60.6 percent of patients reported sufficient functional health literacy, 31.7 patients had problematic functional health literacy and 7.7 percent had inadequate functional health literacy. | There were no differences between the groups in health care contacts ( Table 4) . To our knowledge, this is the first study that has examined whether there is any association between postoperative recovery and functional health literacy in patients undergoing day surgery. We found that patients with inadequate FHL experienced a poor recovery; that is, they reported higher scores in SwQoR on postoperative day 14 compared with patients with sufficient FHL. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33897057585&p=1pl&v=1&x=gsIoyrhoCs5f3L7Wv3ex4w |
10.1073/pnas.1505114112 | Medicine_easy_31 | "Our results support the notion that the adolescent brain remains receptive to training, underscoring the importance of enrichment during the teenage years," the authors write. | Our results support the notion that the adolescent brain remains receptive to training, underscoring the importance of enrichment during teenage years. | They also demonstrated prolonged heightened brain sensitivity to sound details. [related]
All participants improved in language skills important for language and reading, but the improvement was greater for those in music classes, compared with the ROTC group. "Our results support the notion that the adolescent brain remains receptive to training, underscoring the importance of enrichment during the teenage years," the authors write. | These changes seem to benefit literacy skills: both groups improved in phonological awareness relative to the general population, but the music training group improved more compared with the active controls. Our results support the notion that the adolescent brain remains receptive to training, underscoring the importance of enrichment during teenage years. Here, we show that inschool music training begun in high school prolongs the stability of subcortical sound processing and accelerates maturation of cortical auditory responses. | [5] | Medicine | train | 5 | news | http://www.futurity.org/band-teenagers-brains-965992/ |
10.1038/s41467-018-07557-4 | Medicine_easy_32 | "The results show that most fundamental Arctic infrastructure will be at risk, even if the Paris Agreement target is achieved," the authors write. | The results show that most fundamental Arctic infrastructure will be at risk, even if the Paris Agreement target is achieved. | The research is the first to explicitly show the amount of fundamental infrastructure across the Northern Hemisphere that is at risk of structural failure from permafrost thaw caused by climate change. "The results show that most fundamental Arctic infrastructure will be at risk, even if the Paris Agreement target is achieved," the authors write. However, after 2050, attaining the Paris Agreement goals would make a clear difference in potential damage to infrastructure. | Our results demonstrate that ca. The results show that most fundamental Arctic infrastructure will be at risk, even if the Paris Agreement target is achieved. Results show that by 2050 3.6 million people, which constitutes about three quarters of the current population in the Northern Hemisphere permafrost area, may be affected by damage to infrastructure associated with permafrost thaw (Fig. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37952353365&p=1pl&v=1&x=z8k6aIsKNtvV0TWFOzO7Gg |
10.1001/jama.2015.1693 | Medicine_easy_34 | "These findings do not support the use of a balloon-expandable stent for patients with intracranial arterial stenosis," the authors conclude. | These findings do not support the use of a balloon-expandable stent for patients with symptomatic intracranial arterial stenosis. | A measure of disability worsened in more patients in the stent group than in the medical group. "These findings do not support the use of a balloon-expandable stent for patients with intracranial arterial stenosis," the authors conclude. "For endovascular therapy (e.g., angioplasty alone or new stents) to have any role, multicenter pilot studies will be required to establish the safety and potential efficacy of these devices in carefully defined patient populations. | Worsening of baseline disability score (modified Rankin Scale) occurred in more patients in the stent group (14/58; 24.1% [95% CI, 13.9%-37.2%]) vs the medical group (6/53; 11.3% [95% CI,.0%]) (P = .09).The EuroQol-5D showed no difference in any of the 5 dimensions between groups at 12-month follow-up. These findings do not support the use of a balloon-expandable stent for patients with symptomatic intracranial arterial stenosis. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00816166. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2015/03/150324120611.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1001/jama.2015.1693 | Medicine_easy_35 | The 1-year outcome of stroke or hard TIA occurred in more patients in the stent group (36.2 percent) vs the medical group (15.1 percent). | The 1-year primary outcome of stroke or hard TIA occurred in more patients in the stent group (21/58; 36.2% [95% CI, 24.0-49.9]) vs the medical group (8/53; 15.1% [95% CI, 6.7-27.6]) (P = .02). | Intracranial hemorrhage occurred in 5 patients (8.6 percent) in the stent group and in 0 in the medical group. The 1-year outcome of stroke or hard TIA occurred in more patients in the stent group (36.2 percent) vs the medical group (15.1 percent). Thirty day all-cause death was 3 of 58 patients (5.2 percent) in the stent group and 0 in the medical group. | Intracranial hemorrhage within 30 days occurred in more patients in the stent group (5/58; 8.6% [95% CI, 2.9%-19.0%]) vs none in the medical group (95% CI, 0%-5.5%) (P = .06). The 1-year primary outcome of stroke or hard TIA occurred in more patients in the stent group (21/58; 36.2% [95% CI, 24.0-49.9]) vs the medical group (8/53; 15.1% [95% CI, 6.7-27.6]) (P = .02). Worsening of baseline disability score (modified Rankin Scale) occurred in more patients in the stent group (14/58; 24.1% [95% CI, 13.9%-37.2%]) vs the medical group (6/53; 11.3% [95% CI,.0%]) (P = .09).The EuroQol-5D showed no difference in any of the 5 dimensions between groups at 12-month follow-up. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2015/03/150324120611.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1002/cncr.29575 | Medicine_easy_36 | "Our nomograms make it easier to derive individualized predictions of patient outcome; they allow physicians to recognize the risk of distant metastasis or tumor-related death after treatment and provide a more informative explanation for their patients." | Our nomograms make it easier to derive individualized predictions of patient outcome; they allow physicians to recognize the risk of distant metastasis or tumor-related death after treatment and provide a more informative explanation for their patients. | "It is not unusual for musculoskeletal oncologists to encounter patients who develop distant metastasis or suffer tumor-related death even though they receive identical definitive treatment, and the ability to identify such higher risk patients would undoubtedly be valuable," study authors concluded. "Our nomograms make it easier to derive individualized predictions of patient outcome; they allow physicians to recognize the risk of distant metastasis or tumor-related death after treatment and provide a more informative explanation for their patients." They added that the study is limited by its retrospective nature, but that this tool can be used for patient counseling and establishing post-surgical surveillance strategies. | However, it cannot be denied that the appropriate timing of follow-up and the planning of imaging tests should be stratified according to the degree of risk in individual patients. Our nomograms make it easier to derive individualized predictions of patient outcome; they allow physicians to recognize the risk of distant metastasis or tumor-related death after treatment and provide a more informative explanation for their patients. Although they are brief instruments and easy to use, a nomogram that has the potential Figure 2 . | [5] | Medicine | train | 5 | news | http://www.cancernetwork.com/sarcoma/nomograms-help-predict-survival-outcomes-osteosarcoma-patients |
10.1038/s41598-018-30980-y | Medicine_easy_39 | Together, "these results suggest that sleep bouts can interact to benefit memory in early childhood," they conclude. | These results suggest that sleep bouts can interact to benefit memory in early childhood. | Yet nap slow wave activity also predicted greater overnight improvement in memory. Together, "these results suggest that sleep bouts can interact to benefit memory in early childhood," they conclude. Overall, the authors report, "results of this study are consistent with those in procedural memory consolidation in preschool-aged children." | Yet nap slow wave activity also predicted greater overnight improvement in memory. These results suggest that sleep bouts can interact to benefit memory in early childhood. Thus, enhancing emotional learning at this young age has wide-reaching and long-lasting impact. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34884544095&p=1pl&v=1&x=ZTfu4WJpcprjoFwmcebiPw |
10.1001/jama.2014.15690 | Medicine_easy_40 | "Once-daily, low-dose aspirin did not significantly reduce the risk of the composite outcome of cardiovascular death, nonfatal stroke, and nonfatal myocardial infarction among Japanese patients 60 years or older with atherosclerotic risk factors," researchers wrote. | Once-daily, low-dose aspirin did not significantly reduce the risk of the composite outcome of cardiovascular death, nonfatal stroke, and nonfatal myocardial infarction among Japanese patients 60 years or older with atherosclerotic risk factors. | The study showed no difference in risks of fatal or non-fatal heart event deaths between the two groups. "Once-daily, low-dose aspirin did not significantly reduce the risk of the composite outcome of cardiovascular death, nonfatal stroke, and nonfatal myocardial infarction among Japanese patients 60 years or older with atherosclerotic risk factors," researchers wrote. Researchers however said aspirin users should not immediately get off medication before consulting their doctors about risks and benefits. | Reduction in the incidence of colorectal cancer may influence the overall benefit-risk profile of aspirin. Further analyses of the JPPP study data are planned, including analysis of deaths associated with cancers, to allow more precise identification of the patients for whom aspirin treatment may be most beneficial. Once-daily, low-dose aspirin did not significantly reduce the risk of the composite outcome of cardiovascular death, nonfatal stroke, and nonfatal myocardial infarction among Japanese patients 60 years or older with atherosclerotic risk factors. | [5] | Medicine | train | 5 | news | http://www.counselheal.com/articles/13333/20141120/aspirin-cut-heart-problems-risk.htm |
10.1007/s13524-014-0321-x | Medicine_easy_41 | Those who become parents in their teens have a predominantly declining pattern of happiness that does not increase above the baseline even during the year of birth. | Young parents have a predominantly declining pattern of happiness that does not increase above the baseline even during the year of birth. | Older parents, between the ages of 35 -- 49, have the strongest happiness gains around the time of birth and stay at a higher level of happiness after becoming parents. Those who become parents in their teens have a predominantly declining pattern of happiness that does not increase above the baseline even during the year of birth. Those who become parents between the ages of 23 -34 have increasing happiness before a first birth, however one to two years after the birth, happiness decreases to baseline or below. | In the long-run, there are no differences between men and women. Young parents have a predominantly declining pattern of happiness that does not increase above the baseline even during the year of birth. Those who become parents at ages 23-34 have increasing happiness before a first birth and in the year of birth; however, one to two years after the birth, happiness decreases to baseline or below. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2014/10/141028082454.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1186/s13578-015-0003-4 | Medicine_easy_44 | I/R also increased the release of cytochrome c and down-regulated the phosphorylation of PI3K, Akt and GSK-3b in the aging rat hearts. | I/R also increased the release of cytochrome c and down-regulated the phosphorylation of PI3K, Akt and GSK-3β in the aging rat hearts. | I/R also increased the release of cytochrome c and down-regulated the phosphorylation of PI3K, Akt and GSK-3b in the aging rat hearts. We further found that PC increased H2S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. | I/R also increased the release of cytochrome c and down-regulated the phosphorylation of PI3K, Akt and GSK-3β in the aging rat hearts. We further found that PC increased H 2 S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. | [5] | Medicine | train | 5 | news | http://www.technology.org/2015/03/22/a-novel-target-for-the-treatment-of-aging-cardiovascular-diseases/ |
10.1001/jamaneurol.2017.4618 | Medicine_easy_45 | Diffusion-weighted imaging during the acute phase of carbon monoxide poisoning may therefore help identify patients at risk of developing these debilitating sequelae. | Diffusion-weighted imaging during the acute phase of carbon monoxide poisoning may therefore help identify patients at risk of developing these debilitating sequelae. | In addition, the positive and negative predictive values were 73.1 percent and 91.2 percent, respectively. The researchers concluded that the presence of acute brain lesions was significantly associated with the development of delayed neurological sequelae. Diffusion-weighted imaging during the acute phase of carbon monoxide poisoning may therefore help identify patients at risk of developing these debilitating sequelae. | The presence of acute brain lesions was significantly associated with the development of delayed neurological sequelae. Diffusion-weighted imaging during the acute phase of carbon monoxide poisoning may therefore help identify patients at risk of developing these debilitating sequelae. Documenting acute lesions that can potentially indicate the subsequent development of DNS could give clinicians and researchers useful information for understanding the pathophysiology of DNS and targeting prevention. | [5] | Medicine | train | 5 | news | http://www.diagnosticimaging.com/article/imaging-may-identify-potential-delayed-neurological-sequelae-after-carbon-monoxide-poisoning |
10.1186/s13578-015-0003-4 | Medicine_easy_47 | In conclusion, these results demonstrate that exogenous H2S recovers PC-induced cardioprotection via inhibition of oxidative stress and up-regulation of PI3K-Akt-GSK-3b pathway in the aging rat hearts. | In conclusion, these results demonstrate that exogenous H 2 S recovers PC-induced cardioprotection via inhibition of oxidative stress and up-regulation of PI3K-Akt-GSK-3β pathway in the aging rat hearts. | LY294002 (a PI3K inhibitor) abolished but N-acetyl-cysteine (NAC, an inhibitor of reactive oxygen species, ROS) further enhanced the protective role of H2S against I/R induced myocardial damage in the aging hearts. In conclusion, these results demonstrate that exogenous H2S recovers PC-induced cardioprotection via inhibition of oxidative stress and up-regulation of PI3K-Akt-GSK-3b pathway in the aging rat hearts. These findings suggested that H2S might be a novel target for the treatment of aging cardiovascular diseases. | LY294002 (a PI3K inhibitor) abolished but N-acetyl-cysteine (NAC, an inhibitor of reactive oxygen species, ROS) further enhanced the protective role of H 2 S against I/R induced myocardial damage in the aging hearts. In conclusion, these results demonstrate that exogenous H 2 S recovers PC-induced cardioprotection via inhibition of oxidative stress and up-regulation of PI3K-Akt-GSK-3β pathway in the aging rat hearts. These findings suggested that H 2 S might be a novel target for the treatment of aging cardiovascular diseases. | [5] | Medicine | train | 5 | news | http://www.technology.org/2015/03/22/a-novel-target-for-the-treatment-of-aging-cardiovascular-diseases/ |
10.1038/s41467-018-08278-4 | Medicine_easy_48 | "These studies provide evidence that treatment of growth factors can be used to engineer a regeneration response from a non-regenerating amputation wound," explain the researchers in their paper. | These studies provide evidence that treatment of growth factors can be used to engineer a regeneration response from a non-regenerating amputation wound. | That cartilage is a key part of joints, and shows definite progress in limb regeneration. "These studies provide evidence that treatment of growth factors can be used to engineer a regeneration response from a non-regenerating amputation wound," explain the researchers in their paper. The results of the study showed that the regeneration process was most advanced when BMP2 was applied first, with BMP9 added a week after - in this case it led to the growth of more complete joint structures, even with some connections to the bone. | Combining BMP2 and BMP9 treatments in sequence stimulates the regeneration of bone and joint. These studies provide evidence that treatment of growth factors can be used to engineer a regeneration response from a non-regenerating amputation wound. Transient treatment of the amputation wound with BMP induces formation of an endochondral ossification center that organizes the regeneration response of the amputated stump bone . | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=38466420113&p=1pl&v=1&x=IqxylWeo6-sJ6dtu0xtBJQ |
10.1038/s41598-018-30933-5 | Medicine_easy_49 | In three conditions the subject could increase its payoff by choosing the token over the immediately available food, whereas in one condition, choosing the token led to a lower payoff than choosing the food. | In three conditions the subject could increase its payoff by choosing the token over the immediately available food, whereas in one condition, choosing the token led to a lower payoff than choosing the food. | What makes the study of Dr. Krasheninnikova's study so important and novel is that no previous studies of birds have tested decision-making using token exchange methodology. In three conditions the subject could increase its payoff by choosing the token over the immediately available food, whereas in one condition, choosing the token led to a lower payoff than choosing the food. Finally, two conditions presented a situation where there was no difference between the immediate and the future gain, so that the most economic decision was to consume the food immediately." | With this in mind, it is possible to hypothesise that the feeding specialists (the great green and the blue-throated macaws) might encounter a greater need for optimal decision-making as to where and when to go more often than feeding generalists (the African grey parrots and the blue-headed macaws), who may opportunistically take any food they encounter. In three conditions the subject could increase its payoff by choosing the token over the immediately available food, whereas in one condition, choosing the token led to a lower payoff than choosing the food. Finally, two conditions presented a situation where there was no difference between the immediate and the future gain, so that the most economic decision was to consume the food immediately. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37046481434&p=1pl&v=1&x=hbAvZo2c40WZuNN_G5gurQ |
10.1016/j.scitotenv.2019.04.266 | Medicine_easy_50 | "Here again, a good understanding of wildlife consumer demography, economic status, and motivations is essential to the design of effective policy with limited un-intended consequences on more vulnerable communities," the authors write. | Here again, a good understanding of wildlife consumer demography, economic status, and motivations is essential to the design of effective policy with limited unintended consequences on more vulnerable communities. | From questionnaires administered to both seller and buyers, the team found that most consumers bought bushmeat not because they needed the protein, but because they preferred the taste of it to livestock or they saw it as a healthier choice. "Here again, a good understanding of wildlife consumer demography, economic status, and motivations is essential to the design of effective policy with limited un-intended consequences on more vulnerable communities," the authors write. The study found that, in general, the threat of punishment for breaking Laos's laws controlling the trade in wild animals appeared to do little to dissuade vendors. | This suggests that the cost of law enforcement can be internalized by wildlife vendors as part of their business operations, while this cost may not be tolerable at the individual level for a wildlife consumer. Here again, a good understanding of wildlife consumer demography, economic status, and motivations is essential to the design of effective policy with limited unintended consequences on more vulnerable communities. Doing so, we demonstrated high rates of direct contact between bushmeat and people visiting the market, highlighting that this may be an under-estimated route of disease transmission in the bushmeat system. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=39231575932&p=1pl&v=1&x=ugOkJg6MHSJ-5jXepqCzLA |
10.1186/s13578-015-0003-4 | Medicine_easy_51 | We further found that PC increased H2S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. | We further found that PC increased H 2 S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. | I/R also increased the release of cytochrome c and down-regulated the phosphorylation of PI3K, Akt and GSK-3b in the aging rat hearts. We further found that PC increased H2S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. | I/R also increased the release of cytochrome c and down-regulated the phosphorylation of PI3K, Akt and GSK-3β in the aging rat hearts. We further found that PC increased H 2 S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. | [5] | Medicine | train | 5 | news | http://www.technology.org/2015/03/22/a-novel-target-for-the-treatment-of-aging-cardiovascular-diseases/ |
10.1038/s41598-018-25573-8 | Medicine_easy_53 | The tumor closely resembles cancer patient tumor and contains extracellular matrix as well as stromal cells and extensive vasculature. | The tumor closely resembles cancer patient tumor and contains extracellular matrix as well as stromal cells and extensive vasculature. | The scientists had similar results when they used ovarian tumor samples taken directly from patients, showing that their chicken egg model provides a system for replicating human cancer. The tumor closely resembles cancer patient tumor and contains extracellular matrix as well as stromal cells and extensive vasculature. No significant damage to various organs in the chicken embryo occurred. | The tumor closely resembles cancer patient tumor and contains extracellular matrix as well as stromal cells and extensive vasculature. No significant damage to various organs in the chicken embryo occurred. In contrast, injection of free doxorubicin caused widespread organ damage, even when less amount was administered. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34218407527&p=1pl&v=1&x=TZ9cA3HHZNB3jHckRRSErA |
10.1007/s00125-014-3400-z | Medicine_easy_54 | They conclude: "This nationwide retrospective cohort study found a positive correlation of type 1 diabetes with EV infection. | Conclusions/interpretation This nationwide retrospective cohort study found a positive correlation between type 1 diabetes and EV infection. | They add: "Taiwan has relatively low type 1 diabetes incidence; we believe that the marked escalation of the said incidence in recent decades can be largely attributed to the highly endemic spread of enterovirus infection in Taiwanese children, given that there has been little gene flow and genetic drift in such a short period." They conclude: "This nationwide retrospective cohort study found a positive correlation of type 1 diabetes with EV infection. Our results suggest that preventive strategies, such as an effective vaccine against EV infection, may lessen the incidence of type 1 diabetes in Taiwan." | The HRs of type 1 diabetes in children with allergic rhinitis, bronchial asthma or either one of these atopic diseases showed more variation than in those children without these diseases. Conclusions/interpretation This nationwide retrospective cohort study found a positive correlation between type 1 diabetes and EV infection. The results suggest that a preventive strategy, such as an effective vaccine against EV infection, may lessen the incidence of type 1 diabetes in Taiwan. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2014/10/141017183715.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1001/jamasurg.2018.0672 | Medicine_easy_55 | "Health literacy is a relevant factor to consider for optimizing postoperative recovery in patients undergoing day surgery," the researchers conclude. | Health literacy is a relevant factor to consider for optimizing the postoperative recovery in patients undergoing day surgery. | Also, patients with inadequate functional health literacy had a lower health-related quality of life in terms of physical function, bodily pain, vitality, social functioning, mental health and physical aspects. The researchers note that they did not have data on education or socioeconomic status, nor were they aware of how many can speak and read Swedish, which would also pose a challenge to understanding healthcare information, and will require further research. "Health literacy is a relevant factor to consider for optimizing postoperative recovery in patients undergoing day surgery," the researchers conclude. | CONCLUSIONS AND RELEVANCE Inadequate FHL in patients undergoing day surgery was associated with poorer postoperative recovery and a lower health-related quality of life. Health literacy is a relevant factor to consider for optimizing the postoperative recovery in patients undergoing day surgery. 6 Considering this, the association between FHL and postoperative recovery in patients undergoing day surgery needs to be assessed. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=33897057585&p=1pl&v=1&x=gsIoyrhoCs5f3L7Wv3ex4w |
10.1038/s41467-018-04906-1 | Medicine_easy_56 | "Furthermore, this fingerprint sensor array can be integrated with all transparent forms of tactile pressure sensors and skin temperature sensors, to enable the detection of a finger pressing on the display." | Furthermore, this fingerprint sensor array can be integrated with all transparent forms of tactile pressure sensors and skin temperature sensors, to enable the detection of a finger pressing on the display. | This fingerprint sensor array has a high resolution with good transparency," the researchers said. "Furthermore, this fingerprint sensor array can be integrated with all transparent forms of tactile pressure sensors and skin temperature sensors, to enable the detection of a finger pressing on the display." Not only that, the technology could also potentially allow smartphone manufacturers to extend the fingerprint sensor's coverage on a larger portion of a smartphone display. | This sensor with the hybrid electrode also operates at high frequencies with negligible degradation in its performance against various noise signals from mobile devices. Furthermore, this fingerprint sensor array can be integrated with all transparent forms of tactile pressure sensors and skin temperature sensors, to enable the detection of a finger pressing on the display. Therefore, biometrics is a promising approach for ensuring user privacy. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34467889819&p=1pl&v=1&x=bwlU4e1aRXgMmGqDDaSdMA |
10.1038/s41598-018-26198-7 | Medicine_easy_57 | "Together, our results suggest that pro-resolution mechanisms may act in concert with increased cytotoxic immunity to reduce the growth of tumors in response to stretching," the team concludes. | Together, our results suggest that pro-resolution mechanisms may act in concert with increased cytotoxic immunity to reduce the growth of tumors in response to stretching. | Their measurements showed that levels of RvD1 and RvD2 were significantly higher in the stretch group. "Together, our results suggest that pro-resolution mechanisms may act in concert with increased cytotoxic immunity to reduce the growth of tumors in response to stretching," the team concludes. They highlight the "interesting possibility" that stretching could effectively keep inflammation under control, without suppressing the natural cytotoxic immune response against the cancer cells, and then rescuing the cytotoxic function of exhausted T cells. | We therefore measured levels of SPMs within tumors and found that levels of RvD1 and RvD2 were both significantly greater in stretch vs. no-stretch mice (p = 0.04, Fig. Together, our results suggest that pro-resolution mechanisms may act in concert with increased cytotoxic immunity to reduce the growth of tumors in response to stretching. To our knowledge, this is the first report of reduced cancer growth in response to stretching. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34125675804&p=1pl&v=1&x=EIuTbzUDbEKkr7kvXb-kdg |
10.1038/s41598-018-30933-5 | Medicine_easy_58 | Furthermore, "When provided with a choice between a food or a token that could be exchanged for more preferred food, all four species inhibited their impulsive reactions and selected the token significantly more often than chance, thus maximising their payoff. | When provided with a choice between a food or a token that could be exchanged for more preferred food, all four species inhibited their impulsive reactions and selected the token significantly more often than chance, thus maximising their payoff. | And, parrots of the larger macaw species actually did as well or better than primates who have been studied in similar experiments. Furthermore, "When provided with a choice between a food or a token that could be exchanged for more preferred food, all four species inhibited their impulsive reactions and selected the token significantly more often than chance, thus maximising their payoff. They did so regardless of the value of the immediate gain." | These findings parallel earlier findings in primates and suggest that the parrots indeed attributed value to the tokens. When provided with a choice between a food or a token that could be exchanged for more preferred food, all four species inhibited their impulsive reactions and selected the token significantly more often than chance, thus maximising their payoff. They did so regardless of the value of the immediate gain, i.e., low (condition 1) or medium (condition 2). | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37046481434&p=1pl&v=1&x=hbAvZo2c40WZuNN_G5gurQ |
10.1038/s41598-018-25573-8 | Medicine_easy_60 | No significant damage to various organs in the chicken embryo occurred. | No significant damage to various organs in the chicken embryo occurred. | The tumor closely resembles cancer patient tumor and contains extracellular matrix as well as stromal cells and extensive vasculature. No significant damage to various organs in the chicken embryo occurred. In contrast, injection of free doxorubicin caused widespread organ damage, even when less amount was administered," write the investigators. | The tumor closely resembles cancer patient tumor and contains extracellular matrix as well as stromal cells and extensive vasculature. No significant damage to various organs in the chicken embryo occurred. In contrast, injection of free doxorubicin caused widespread organ damage, even when less amount was administered. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34218407527&p=1pl&v=1&x=TZ9cA3HHZNB3jHckRRSErA |
10.1001/jamainternmed.2016.0157 | Medicine_easy_62 | "From a public health perspective, our study supports partnership of app developers, distributors, and regulatory bodies to set and follow standards for safe, validated mHealth technologies," the researchers conclude. | From a public health perspective, our study supports partnership of app developers, distributors, and regulatory bodies to set and follow standards for safe, validated mHealth technologies. | These measurements correlated with the lowest possible accuracy grade in all categories by British Hypertensive Society scoring. These study findings demonstrate that the mHealth app produced highly inaccurate readings, which could give more than three-fourths (77.5%) of persons with hypertensive BP levels false reassurance that their BP is in the nonhypertensive range. "From a public health perspective, our study supports partnership of app developers, distributors, and regulatory bodies to set and follow standards for safe, validated mHealth technologies," the researchers conclude. | Hence, we remain concerned that individuals may use these apps to assess their BP and titrate therapy. From a public health perspective, our study supports partnership of app developers, distributors, and regulatory bodies to set and follow standards for safe, validated mHealth technologies. Between its release on June 5, 04, and removal on July 0, 05 (4 days), the IBP app spent 56 days as one of the top 50 best-selling iPhone apps; at least 950 copies of this $4.99 app were sold on each of those days. | [5] | Medicine | train | 5 | news | http://www.oncologynurseadvisor.com/instant-blood-pressure-mobile-app-fails-validation-study/article/484459/ |
10.1038/s41598-018-25573-8 | Medicine_easy_63 | These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer." | These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer. | Lastly, a tumor could be established in the egg using tumor samples from ovarian cancer patients and that our nanoparticles were effective in eliminating the tumor. These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer." "We were surprised when the tumor was formed in three days," notes Dr. Tamanoi. | Lastly, a tumor could be established in the egg using tumor samples from ovarian cancer patients and that our nanoparticles were effective in eliminating the tumor. These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer. Tumor recurrence and metastasis are primarily responsible for the 70% five-year mortality of advanced EOC. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34218407527&p=1pl&v=1&x=TZ9cA3HHZNB3jHckRRSErA |
10.1038/s41598-018-25573-8 | Medicine_easy_64 | Furthermore, we observed excellent tumor accumulation of the nanoparticles. | Furthermore, we observed excellent tumor accumulation of the nanoparticles. | "The lack of toxic effect of nanoparticle loaded doxorubicin was associated with specific delivery of doxorubicin to the tumor. Furthermore, we observed excellent tumor accumulation of the nanoparticles. Lastly, a tumor could be established in the egg using tumor samples from ovarian cancer patients and that our nanoparticles were effective in eliminating the tumor. | The lack of toxic effect of nanoparticle loaded doxorubicin was associated with specific delivery of doxorubicin to the tumor. Furthermore, we observed excellent tumor accumulation of the nanoparticles. Lastly, a tumor could be established in the egg using tumor samples from ovarian cancer patients and that our nanoparticles were effective in eliminating the tumor. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34218407527&p=1pl&v=1&x=TZ9cA3HHZNB3jHckRRSErA |
10.1038/s41598-018-25573-8 | Medicine_easy_65 | "The lack of toxic effect of nanoparticle loaded doxorubicin was associated with specific delivery of doxorubicin to the tumor. | The lack of toxic effect of nanoparticle loaded doxorubicin was associated with specific delivery of doxorubicin to the tumor. | In contrast, injection of free doxorubicin caused widespread organ damage, even when less amount was administered," write the investigators. "The lack of toxic effect of nanoparticle loaded doxorubicin was associated with specific delivery of doxorubicin to the tumor. Furthermore, we observed excellent tumor accumulation of the nanoparticles. | In contrast, injection of free doxorubicin caused widespread organ damage, even when less amount was administered. The lack of toxic effect of nanoparticle loaded doxorubicin was associated with specific delivery of doxorubicin to the tumor. Furthermore, we observed excellent tumor accumulation of the nanoparticles. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=34218407527&p=1pl&v=1&x=TZ9cA3HHZNB3jHckRRSErA |
10.1001/jama.2013.277165 | Medicine_easy_66 | Study anticoagulant was discontinued because of bleeding in 242 patients (4.7 percent) in the otamixaban group and in 95 patients (1.7 percent) in the UFH-plus-eptifibatide group. | Study anticoagulant was discontinued because of bleeding in 242 patients (4.7%) in the otamixaban group and in 95 patients (1.7%) in the UFH-pluseptifibatide group (P < .001). | Otamixaban consistently increased all types of bleeding events, regardless of the severity or bleeding classification scheme used. Study anticoagulant was discontinued because of bleeding in 242 patients (4.7 percent) in the otamixaban group and in 95 patients (1.7 percent) in the UFH-plus-eptifibatide group. "Otamixaban did not reduce ischemic events compared with UFH plus eptifibatide but increased bleeding among patients with NSTE-ACS and a planned invasive strategy. | Otamixaban consistently increased all types of bleeding events, regardless of the severity or bleeding classification scheme used (Table 2 ; and eTable 4 in the Supplement), and without interaction across patient subsets, including demographics, previous treatment, risk scores, biomarkers or management (eFigure 3B and eFigure 4 in the Supplement). Study anticoagulant was discontinued because of bleeding in 242 patients (4.7%) in the otamixaban group and in 95 patients (1.7%) in the UFH-pluseptifibatide group (P < .001). Except for bleeding, there were no differences in the rate of adverse events or serious adverse events or liver-function abnormalities (eTable 5 in the Supplement). | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2013/09/130901153354.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1186/s13578-015-0003-4 | Medicine_easy_69 | Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. | Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. | We further found that PC increased H2S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. LY294002 (a PI3K inhibitor) abolished but N-acetyl-cysteine (NAC, an inhibitor of reactive oxygen species, ROS) further enhanced the protective role of H2S against I/R induced myocardial damage in the aging hearts. | We further found that PC increased H 2 S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. LY294002 (a PI3K inhibitor) abolished but N-acetyl-cysteine (NAC, an inhibitor of reactive oxygen species, ROS) further enhanced the protective role of H 2 S against I/R induced myocardial damage in the aging hearts. | [5] | Medicine | train | 5 | news | http://www.technology.org/2015/03/22/a-novel-target-for-the-treatment-of-aging-cardiovascular-diseases/ |
10.1038/s41598-018-30933-5 | Medicine_easy_73 | Individuals representing great green macaws did the best of all of the species studied in that all of them "performed significantly above chance throughout all six test conditions, suggesting that they successfully weighed up between the two options to make the most advantageous choice." | In summary, on a group level, the great green macaws were the only species in which most of the individuals performed significantly above chance throughout all six test conditions, suggesting that they successfully weighed up between the two options to make the most advantageous choice. | They did so regardless of the value of the immediate gain." Individuals representing great green macaws did the best of all of the species studied in that all of them "performed significantly above chance throughout all six test conditions, suggesting that they successfully weighed up between the two options to make the most advantageous choice." It's interesting to ask about the ecological relevance of this study and how the results reflect what parrots have to do in the wild. | Five of 13 Goffin cockatoos selected their most preferred food over a tool that could be used to obtain the same food (an analogue to condition 6 in the present study). In summary, on a group level, the great green macaws were the only species in which most of the individuals performed significantly above chance throughout all six test conditions, suggesting that they successfully weighed up between the two options to make the most advantageous choice. These findings are in line with previous studies showing that cockatoos, a distantly related psittaciforme, also decide economically. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37046481434&p=1pl&v=1&x=hbAvZo2c40WZuNN_G5gurQ |
10.1001/jamaneurol.2015.0475 | Medicine_easy_74 | Although absolute risks for neuropathy are low, CD is a potentially treatable condition with a young age of onset. | Although absolute risks for neuropathy are low, CD is a potentially treatable condition with a young age of onset. | "We found an increased risk of neuropathy in patients with CD [celiac disease] that persists after CD diagnosis. Although absolute risks for neuropathy are low, CD is a potentially treatable condition with a young age of onset. Our findings suggest that screening could be beneficial in patients with neuropathy," researchers wrote in an article detailing their study. | We found an increased risk of neuropathy in patients with CD that persists after CD diagnosis. Although absolute risks for neuropathy are low, CD is a potentially treatable condition with a young age of onset. Our findings suggest that screening could be beneficial in patients with neuropathy. | [5] | Medicine | train | 5 | news | http://www.techtimes.com/articles/52228/20150512/celiac-disease-linked-to-nerve-disease-in-neuropathy-patients-is-gluten-to-blame.htm |
10.1001/jamaneurol.2017.4618 | Medicine_easy_75 | The sensitivity and specificity of acute brain lesions to assess the probability of delayed neurological sequelae were 75.2 percent and 90.2 percent, respectively. | The sensitivity and specificity of acute brain lesions to assess the probability of delayed neurological sequelae were 75.2% (95% CI, 66.8%-83.7%) and 90.2% (95% CI, 86.8%-93.7%), respectively. | Multivariable logistic regression analysis indicated that the presence of acute brain lesions was independently associated with development of delayed neurological sequelae. The sensitivity and specificity of acute brain lesions to assess the probability of delayed neurological sequelae were 75.2 percent and 90.2 percent, respectively. In addition, the positive and negative predictive values were 73.1 percent and 91.2 percent, respectively. | Multivariable logistic regression analysis indicated that the presence of acute brain lesions was independently associated with development of delayed neurological sequelae (adjusted odds ratio, 13.93; 95% CI, 7.16-27.11; P < .001). The sensitivity and specificity of acute brain lesions to assess the probability of delayed neurological sequelae were 75.2% (95% CI, 66.8%-83.7%) and 90.2% (95% CI, 86.8%-93.7%), respectively. In addition, the positive and negative predictive values were 73.1% (95% CI, 64.6%-81.6%) and 91.2% (95% CI, 87.9%-94.5%), respectively. | [5] | Medicine | train | 5 | news | http://www.diagnosticimaging.com/article/imaging-may-identify-potential-delayed-neurological-sequelae-after-carbon-monoxide-poisoning |
10.1002/ijc.28956 | Medicine_easy_76 | "However the risk of death due to melanoma in this age group is generally low except among a small proportion of cases whose melanomas were already more than 1 mm thick when diagnosed," Professor Green said. | However, the risk of death due to melanoma in this age group is generally low except among a small proportion of cases whose melanomas are already >1 mm thick when diagnosed. | As expected in the state's sunny climate, young Queenslanders are still up to five times more likely to be diagnosed with melanoma than young people in the US or Europe. "However the risk of death due to melanoma in this age group is generally low except among a small proportion of cases whose melanomas were already more than 1 mm thick when diagnosed," Professor Green said. "This generally favourable outcome is likely due, in large part, to early detection, resulting from increased skin cancer awareness." | In conclusion, our study shows that the incidence rates of invasive melanoma are relatively high in adolescents and young adults in Queensland compared with other white populations as expected due to the state's sunny climate. However, the risk of death due to melanoma in this age group is generally low except among a small proportion of cases whose melanomas are already >1 mm thick when diagnosed. We have also shown that the incidence of thin invasive melanoma has declined since the mid-to late 1990s among young people who have been exposed to Queensland's primary prevention and early detection programs since birth. | [5] | Medicine | train | 5 | news | http://www.healthcanal.com/cancers/skin-cancer/51127-melanoma-rates-dropping-in-young-queenslanders.html |
10.1186/s13578-015-0003-4 | Medicine_easy_77 | These findings suggested that H2S might be a novel target for the treatment of aging cardiovascular diseases. | These findings suggested that H 2 S might be a novel target for the treatment of aging cardiovascular diseases. | LY294002 (a PI3K inhibitor) abolished but N-acetyl-cysteine (NAC, an inhibitor of reactive oxygen species, ROS) further enhanced the protective role of H2S against I/R induced myocardial damage in the aging hearts. In conclusion, these results demonstrate that exogenous H2S recovers PC-induced cardioprotection via inhibition of oxidative stress and up-regulation of PI3K-Akt-GSK-3b pathway in the aging rat hearts. These findings suggested that H2S might be a novel target for the treatment of aging cardiovascular diseases. | In conclusion, these results demonstrate that exogenous H 2 S recovers PC-induced cardioprotection via inhibition of oxidative stress and up-regulation of PI3K-Akt-GSK-3β pathway in the aging rat hearts. These findings suggested that H 2 S might be a novel target for the treatment of aging cardiovascular diseases. PC can be evoked by applying cycles of brief intermittent interruption of blood flow to the myocardium at the immediate onset of reperfusion after a prolonged period of ischemia. | [5] | Medicine | train | 5 | news | http://www.technology.org/2015/03/22/a-novel-target-for-the-treatment-of-aging-cardiovascular-diseases/ |
10.1001/jama.2018.14619 | Medicine_easy_78 | "Health care professionals should engage patients with severe obesity and type 2 diabetes in a shared decision making conversation about the potential role of bariatric surgery in the prevention of macrovascular events," the authors write. | Health care professionals should engage patients with severe obesity and type 2 diabetes in a shared decision making conversation about the potential role of bariatric surgery in the prevention of macrovascular events. | At five years, bariatric surgery correlated with a lower composite incidence of macrovascular events (2.1 versus 4.3 percent; hazard ratio, 0.60; 95 percent confidence interval, 0.42 to 0.86) and lower incidence of coronary artery disease (1.6 versus 2.8 percent; hazard ratio, 0.64; 95 percent confidence interval, 0.42 to 0.99). At five years, the incidence of cerebrovascular disease did not differ significantly between the groups (0.7 versus 1.7 percent; hazard ratio, 0.69; 95 percent confidence interval, 0.38 to 1.25). "Health care professionals should engage patients with severe obesity and type 2 diabetes in a shared decision making conversation about the potential role of bariatric surgery in the prevention of macrovascular events," the authors write. | The findings require confirmation in randomized clinical trials. Health care professionals should engage patients with severe obesity and type 2 diabetes in a shared decision making conversation about the potential role of bariatric surgery in the prevention of macrovascular events. [5] [6] [7] [8] [9] In comparison, patients who have bariatric surgery have better glycemic control and greater macrovascular risk factor reduction than those who get both intensive lifestyle and medical treatment combined. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37411788291&p=1pl&v=1&x=z91QmlOw-rhPBgdbiO_iaQ |
10.1001/jamaneurol.2015.0475 | Medicine_easy_79 | Our findings suggest that screening could be beneficial in patients with neuropathy," researchers wrote in an article detailing their study. | Our findings suggest that screening could be beneficial in patients with neuropathy. | "We found an increased risk of neuropathy in patients with CD [celiac disease] that persists after CD diagnosis. Although absolute risks for neuropathy are low, CD is a potentially treatable condition with a young age of onset. Our findings suggest that screening could be beneficial in patients with neuropathy," researchers wrote in an article detailing their study. | We found an increased risk of neuropathy in patients with CD that persists after CD diagnosis. Although absolute risks for neuropathy are low, CD is a potentially treatable condition with a young age of onset. Our findings suggest that screening could be beneficial in patients with neuropathy. | [5] | Medicine | train | 5 | news | http://www.techtimes.com/articles/52228/20150512/celiac-disease-linked-to-nerve-disease-in-neuropathy-patients-is-gluten-to-blame.htm |
10.1111/cdev.12370 | Medicine_easy_80 | In turn, these new insights were associated with less emotional distress. | This process could be especially useful in regulating emotions during adolescence, a period characterized by more powerful and frequent negative emotional experiences than any other ). | They were also less likely to continue to blame the other person involved in the event (though not less likely to forgive him or her). In turn, these new insights were associated with less emotional distress. "In fact, they were dealing with them in a more adaptive way." | These findings highlight the role that self-distancing plays in fostering adaptive self-reflection in adolescence, and begin to elucidate the role that development plays in enhancing the benefits of engaging in this process. This process could be especially useful in regulating emotions during adolescence, a period characterized by more powerful and frequent negative emotional experiences than any other ). Analyzing negative experiences from a self-distanced perspective led participants to focus less on recounting the emotional details of the event and more on reconstruing it in ways that promoted insight and closure. | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2015/04/150415092801.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1534/genetics.116.197285 | Medicine_easy_81 | In only a handful of generations you go from having almost no copies of the mutation in the population to it being 'fixed' so every individual in the population has it -- at least that was the simple theory." | For example, when the driver has a dominant fitness cost of s dd = 0.1, resistance alleles would have to be present at . | "That might include the CRISPR/Cas9 machinery but also a new gene that provides resistance to dengue fever in the mosquito, for example, so the two spread together. In only a handful of generations you go from having almost no copies of the mutation in the population to it being 'fixed' so every individual in the population has it -- at least that was the simple theory." Yet, faced with the new and sophisticated CRISPR/Cas9 method of gene drive, nature is still likely to fight back to resist the mutation successfully, Unckless said. | 2). For example, when the driver has a dominant fitness cost of s dd = 0.1, resistance alleles would have to be present at . Note that we would expect this to be the case in scenarios with δ > 10 -3 (SI section 3.1). | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/research-shows-nature-can-beat-back-scientific-tinkering-with-genes-of-entire-species/ |
10.1001/jama.2018.7028 | Medicine_easy_82 | It goes without saying humans do not face the same stressors as those who called earth home millions of years ago. | Findings from the present study demonstrated that not only patients with PTSD, but also individuals with other and more common stress-related disorders, experienced considerably increased relative risk of autoimmune disease. | The chemicals released by your brain that make you nervous around your crush are the same ones that alarmed your archaic ancestors of possible predators. It goes without saying humans do not face the same stressors as those who called earth home millions of years ago. The findings were alarming. | 22 These findings gain support from previous studies of male Vietnam War veterans 10,11 linking self-reported symptoms of PTSD to higher prevalence of a few selected autoimmune diseases. Findings from the present study demonstrated that not only patients with PTSD, but also individuals with other and more common stress-related disorders, experienced considerably increased relative risk of autoimmune disease. Although the present findings are of etiologic importance, the relatively modest differences in incidence rates of autoimmune disease between the exposed and unexposed individuals (9.1 and 6.0 per 1000 person-years, respectively) do not provide direct evidence for altered clinical management or monitoring of persons with stress-related disorders. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34371117916&p=1pl&v=1&x=bgKj_4ZxA1hgbO_2itXByg |
10.1016/j.cell.2018.04.038 | Medicine_easy_85 | TRAP plays a crucial role in adding on small pieces of DNA to the ends of chromosomes to keep them from shortening every time cells divide. | Direct telomerase activity assays with dGTP on the purified telomerase confirmed that the DNA binds and a single dG is added in the expected register (Figure S1) . | When telomerase is not active, each time the cells divide, the telomeres get shorter. TRAP plays a crucial role in adding on small pieces of DNA to the ends of chromosomes to keep them from shortening every time cells divide. The researchers report for the first time the structure, shape and significance of TRAP, and the region with which it interacts. | The structure reveals how the sstDNA and TERT-specific domains, including a previously uncharacterized domain, interact with TER and each other to regulate the catalytic cycle and how telomere-interacting proteins bind to TERT, and it explains decades of biochemical and mutagenesis data on ciliate and human telomerase. Direct telomerase activity assays with dGTP on the purified telomerase confirmed that the DNA binds and a single dG is added in the expected register (Figure S1) . As observed for DNA-free telomerase, sstDNA-bound telomerase is conformationally heterogeneous (see Method Details). | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34239565585&p=1pl&v=1&x=dKdwlCB2iE4axi2krXvE_w |
10.1016/j.cell.2015.07.058 | Medicine_easy_86 | When it comes to defending against DNA viruses, however, the Salk team found something interesting: the cell's response system begins the same way (with MRN detecting either DNA or viral breaks) but never progresses to the global alarm signal in the case of the virus. | However, similar to SAECs, the levels of virus genomes are 10 4 times higher in WT versus DE1B-55K/DE4-ORF3-infected A549 cells ( Figure 2B ). | "This response prevents replication so the cell doesn't pass on a break." When it comes to defending against DNA viruses, however, the Salk team found something interesting: the cell's response system begins the same way (with MRN detecting either DNA or viral breaks) but never progresses to the global alarm signal in the case of the virus. The cell detects the unauthorized replication and the MRN complex grabs and selectively neutralizes viral DNA without triggering a global response that would arrest or kill the cell. | Adenovirus replication is accelerated by about 12 hr in A549 cells. However, similar to SAECs, the levels of virus genomes are 10 4 times higher in WT versus DE1B-55K/DE4-ORF3-infected A549 cells ( Figure 2B ). In WT-virus-infected cells, neither MR knockdown nor Mirin prevents the global phosphorylation of DDR substrates ( Figure 2C ). | [1] | Medicine | train | 1 | news | http://www.healthcanal.com/cancers/66433-the-dna-damage-response-goes-viral-a-way-in-for-new-cancer-treatments.html |
10.1016/j.bodyim.2016.09.005 | Medicine_easy_87 | This research has drawn up similar conclusions the doll is giving children an unrealistic image that being slim is better. | This condition provided no feedback about the movement of Barbie's body. | This was not the first time researchers claim Barbie dolls affect young girls' body image. This research has drawn up similar conclusions the doll is giving children an unrealistic image that being slim is better. The researchers suggested parents should emphasize and discuss what entails having a healthy body with their little girls so that they can develop good body image concepts. | This condition also enabled a comparison to the findings of . This condition provided no feedback about the movement of Barbie's body. ", similar to the measure used by with early school-aged children. | [1] | Medicine | train | 1 | news | http://www.parentherald.com/articles/97873/20170130/barbie-dolls-harm-little-girls-body-image-experts-advise-parents.htm |
10.1186/2045-5380-3-19 | Medicine_easy_88 | It works by heightening CNS connections to control hyperactivity and impulses. | Taken together, this review of the preclinical research regarding the role of the eCB system in the regulation of stress and emotional behavior creates a compelling argument that eCB signaling acts to constrain activation of the stress response, and the ensuing neuroendocrine and behavioral responses to stress. | As such, the potential CBD shows as the most effective natural alternative to Adderall is very significant. It works by heightening CNS connections to control hyperactivity and impulses. This, in turn, helps improve focus and attention in those with ADHD. | Possible mechanisms of action of eCB augmentation in the mitigation of stress-induced behavioral dysregulation include modulation of hippocampal neurogenesis and amygdala dendritic hypertrophy . Taken together, this review of the preclinical research regarding the role of the eCB system in the regulation of stress and emotional behavior creates a compelling argument that eCB signaling acts to constrain activation of the stress response, and the ensuing neuroendocrine and behavioral responses to stress. In response to stress, particularly stress of high emotional load or repeated exposure to a common stressor, there is a mobilization of 2-AG, which seems to be important for restricting the magnitude of the stress response and aiding in normative recovery to pre-stress levels of functioning. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38859700967&p=1pl&v=1&x=UP_btp_fYMUlHDGz6aK1Xw |
10.1111/all.13333 | Medicine_easy_89 | The study suggested that the seasonal flu vaccine may not be effective in preventing hospitalization due to influenza community-acquired pneumonia. | The success of vaccination programs was affected by complex factors such as the nature of healthcare provision (eg, free care or insurance-based), education levels, and cultural acceptance of the vaccine. | Advertisement
Follow eMaxHealth on YouTube, Twitter and Facebook Please, click to subscribe to our Youtube Channel to be notified about upcoming health and food tips. The study suggested that the seasonal flu vaccine may not be effective in preventing hospitalization due to influenza community-acquired pneumonia. Important implication also says that while vaccines may be a primary prevention strategy they are not 100% effective. | Pediatricians were more likely than family physicians to routinely recommend influenza vaccination to children with asthma (adjusted OR 3.49, 95% CI 1.68-7.22), with decisions also being made depending on asthma phenotype (ie, intermittent vs. persistent). The success of vaccination programs was affected by complex factors such as the nature of healthcare provision (eg, free care or insurance-based), education levels, and cultural acceptance of the vaccine. Therefore, national health surveys with information on vaccination status linked with medical and socio-demographic details (such as that of Spain with data spanning more than 2 decades ) can aid in assessing the impact of influenza vaccination, at population level. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37849057616&p=1pl&v=1&x=xt4Zpy97jdfgJxOWwQtwhA |
10.1186/s12916-017-0986-2 | Medicine_easy_90 | "Older adults are a diverse group of patients whose risk of postoperative complications is not solely defined by their age, co-morbidities (multiple health problems) or the type of surgical procedure they receive," Watt said. | Among patients undergoing cardiac surgery, the pooled incidence of mortality was 5.21% (4.00-6.75%, 6 studies, I 2 = 60.8%, NNF = 20). | "The fact that age and ASA status were not risk factors for postoperative complications is somewhat surprising because these are the factors a clinician would typically look at when assessing a patient's risk of developing complications after surgery," study author Dr. Jennifer Watt said in a hospital news release. "Older adults are a diverse group of patients whose risk of postoperative complications is not solely defined by their age, co-morbidities (multiple health problems) or the type of surgical procedure they receive," Watt said. "This study highlights how common postoperative complications are among older adults undergoing elective surgery, and the importance of geriatric syndromes, including frailty, in identifying older adults who may be at risk," she said. | The pooled incidence of mortality was 4.58% (95% CI 3.67-5.71%, 11 studies, I 2 = 46.30%, NNF = 21) [1-3, 25, 30, 32, 51, 53, 55-57] . Among patients undergoing cardiac surgery, the pooled incidence of mortality was 5.21% (4.00-6.75%, 6 studies, I 2 = 60.8%, NNF = 20). Only the effects of publication year could be explored in a meta-regression because there were not enough studies to explore the effects of type of surgery or mean age of patients on the pooled incidence of mortality. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33000673455&p=1pl&v=1&x=ZUA80X35mG1U_VnPyqM0hw |
10.1001/jamapsychiatry.2018.1941 | Medicine_easy_91 | Getting to the bottom of exactly what's going on will require more research, but one of the more promising avenues to explore is the role of the lateral orbitofrontal cortex. | Key areas shown include the lateral orbitofrontal cortex, the dorsolateral prefrontal cortex, the anterior and posterior cingulate cortices, and the insula. | While this particular study found strong neural connections in the association of depressive problems with poor sleep quality, rather than the other way around, in general the effects can work both ways. Getting to the bottom of exactly what's going on will require more research, but one of the more promising avenues to explore is the role of the lateral orbitofrontal cortex. Specifically targeting this part of the brain with treatments, the study authors say, could lead to some major progress being made. | With the Depressive Problems Score eFigure 4 and eTable 2 in the Supplement show correlations between the functional connectivities across the whole brain and the Depressive Problems score. Key areas shown include the lateral orbitofrontal cortex, the dorsolateral prefrontal cortex, the anterior and posterior cingulate cortices, and the insula. If the 92 participants who had ever been diagnosed with depression were removed from this analysis, the correlations of some of these areas with the Depressive Problems score were still significant, including the anterior cingulate gyrus and middle frontal gyrus (middle frontal gyrus with right anterior cingulate cortex: r = 0.115; P = .001; left cuneus with left superior frontal gyrus, dorsolateral: r = −0.109; P = .002; right inferior parietal gyrus, excluding supramarginal and angular gyri with left middle cingulate and paracingulate gyri: r = 0.059; P = .01; right middle frontal gyrus with left anterior cingulate cortex: r = 0.059; P = .01; left postcentral gyrus with left inferior temporal lobe: r = 0.059; P = .01; eTable 2 in the Supplement). | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34644678837&p=1pl&v=1&x=NPMHP58RsDT7VzhGCx19YA |
10.1038/s41467-018-08278-4 | Medicine_easy_92 | Die Wissenschaftler konnten das Wachstum in geschadigten oder amputierten Gliedmassen von Mausen mit nur zwei Proteinen kunstlich stimulieren: BMP2 und BMP9. | In cavity-forming digits, the nodule is not next to the BMP9 bead and BrdU-labeled chondrocytes are not present, indicating that BMP9 does not stimulate chondrocyte proliferation (Supplementary Fig. | Die Wissenschaftler konnten das Wachstum in geschadigten oder amputierten Gliedmassen von Mausen mit nur zwei Proteinen kunstlich stimulieren: BMP2 und BMP9. Das konnte Sie auch interessieren
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Die Regeneration von Knochen wurde auch fruher erreicht, aber ohne das zusatzliche Protein wurden die Knochen zum Beispiel nach einer Fraktur zusammenwachsen, anstatt Gelenk- und Knorpelgewebe zu vergrossern. Zwar ist die Studie nur ein kleiner Schritt, sie konnte aber zu einem grossem Fortschritt bei der Behandlung von Erkrankungen wie Arthrose fuhren. | These data indicate that BMP9 stimulates the aggregation and differentiation of chondrocytes but their progression to hypertrophic chondrocytes is delayed compared to BMP2-treated digits . In cavity-forming digits, the nodule is not next to the BMP9 bead and BrdU-labeled chondrocytes are not present, indicating that BMP9 does not stimulate chondrocyte proliferation (Supplementary Fig. The absence of proliferating chondrocytes and delayed hypertrophic differentiation distinguishes the BMP9 response from BMP2 stimulation of endochondral ossification . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38488446029&p=1pl&v=1&x=pEPzQn-OGtRw5F4FBoLIWA |
10.1016/j.neuron.2017.06.028 | Medicine_easy_93 | The findings are published in the journal Neuron and have the potential to reveal new therapeutic strategies for neurological and psychiatric disorders. | In absence of BCAN, GluA1 fails to cluster in postsynaptic densities and this seems to cause a loss of excitatory synaptic contacts onto PV+ interneurons. | The findings are published in the journal Neuron and have the potential to reveal new therapeutic strategies for neurological and psychiatric disorders. As such, unravelling key molecular players in this form of plasticity may pave the way for new treatments. The researchers also found that this protein shapes the intrinsic properties of PV+ interneurons and sculpts their connections to other neurons. | BCAN affects excitatory synaptic differentiation, at least in part by modulating the levels of GluA1 receptor at the synapse. In absence of BCAN, GluA1 fails to cluster in postsynaptic densities and this seems to cause a loss of excitatory synaptic contacts onto PV+ interneurons. Since the specific depletion of GluA1 from PV+ cells causes a similar phenotype, it is unlikely that the reduction in GluA1 observed in Bcan mutants is due to the loss of synapses by a GluA1-independent mechanism. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/how-neurons-sense-our-everyday-life/ |
10.1016/j.cell.2016.09.056 | Medicine_easy_94 | For example, the work could assist researchers who are taking aim at the tetraspanin CD37 in clinical trials to treat chronic lymphocytic leukemia and non-Hodgkin lymphoma. | However, it now seems at least equally likely that other factors are more responsible for the creation of tetraspanin-enriched microdomains than direct interactions between tetraspanins themselves. | Illuminating dark matter
In addition to helping researchers understand and potentially target CD81, the discovery may illuminate other tetraspanins and their disease connections because they likely share CD81's structure, the researchers say. For example, the work could assist researchers who are taking aim at the tetraspanin CD37 in clinical trials to treat chronic lymphocytic leukemia and non-Hodgkin lymphoma. Even if clinical applications don't pan out, though, the work excites Blacklow because it represents one of the last remaining opportunities to illuminate "dark matter" in transmembrane protein biology, he said. | An important caveat from our structure is the fact that four intracellular cysteine residues were mutated to prevent disulfide crosslinking during purification. However, it now seems at least equally likely that other factors are more responsible for the creation of tetraspanin-enriched microdomains than direct interactions between tetraspanins themselves. Our results reveal that CD81 binds cholesterol and that E219 is an important residue in the binding pocket, offering a potential mechanism for how tetraspanins might detect cholesterol or other membrane lipids (whereas CD81 and tspan10 both possess a polar residue in this position, most other tetraspanins have a polar residue one helical turn earlier, with other cholesterol-interacting residues highly conserved throughout evolution). | [1] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/Ay74vlkGcfw/ |
10.1111/cdev.12250 | Medicine_easy_95 | Worse yet, findings revealed that many were also more likely to encounter issues with substance abuse. | Although no measures of pubertal status were available in this study, by the ages of 13-15, the period during which pseudomature behavior was observed, the vast majority of teens are well into puberty. | In fact, researchers discovered that by around 22, most school celebrities had been denoted to just your average Joe. Worse yet, findings revealed that many were also more likely to encounter issues with substance abuse. "The student who was popular and was running with the fast crowd isn't doing as great later on." | Second, one question that might be asked regarding these findings is how they relate to the pubertal status of early adolescents, which has been inconsistently linked to delinquent and romantic behavior . Although no measures of pubertal status were available in this study, by the ages of 13-15, the period during which pseudomature behavior was observed, the vast majority of teens are well into puberty. This fact, plus the lack of consistent links between pubertal timing and delinquent and romantic behavior in the existing literature, suggests that prior differences in pubertal timing are unlikely to account for the findings observed. | [1] | Medicine | train | 1 | news | http://www.scienceworldreport.com/articles/15380/20140612/treatment-of-sleep-apnea-helps-improve-heart-health.htm |
10.1186/gb-2013-14-7-r73 | Medicine_easy_97 | Importantly, removal of these RNAs causes the death of cancer cells providing a clear direction for the development of therapeutics and better diagnostics for cancer patients. | All this begs the question of what such huge transcripts could be doing. | Researchers found that some of these vlincRNAs are co-opted by cancer-associated transcriptional programs. Importantly, removal of these RNAs causes the death of cancer cells providing a clear direction for the development of therapeutics and better diagnostics for cancer patients. VlincRNAs may contribute to the regulation of gene expression in the nucleus of the cell. | These findings should signal re-evaluation of the results of GWAS studies where disease-associated variants are often found outside of known genes. All this begs the question of what such huge transcripts could be doing. While some of these vlincRNA regions could possibly produce spliced protein-coding transcripts, the long un-spliced versions of these RNAs would very unlikely code for proteins, especially considering that, for the most part, they localize to the nucleus (data not shown). | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2013/07/130731093915.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1534/genetics.116.197285 | Medicine_easy_98 | "Basically, looking at the numbers and assuming a simple gene drive system, it's a foregone conclusion that resistance will evolve," Unckless said. | In heterozygotes, the driver can cleave the sister chromosome at the target site and insert itself via homology-directed repair, converting heterozygotes for the driver construct into homozygotes (Fig. | They show nature still has the edge over scientists hoping to solve human problems with GM organisms. "Basically, looking at the numbers and assuming a simple gene drive system, it's a foregone conclusion that resistance will evolve," Unckless said. We argue resistance could be thought of as a good thing -- if we know it's going to evolve, we can plan around it, and understand a gene drive is a temporary solution. | This study highlights the need for careful modeling of CGD prior to the actual release of a driver construct into the wild. In heterozygotes, the driver can cleave the sister chromosome at the target site and insert itself via homology-directed repair, converting heterozygotes for the driver construct into homozygotes (Fig. In addition, arbitrary genetic segments can be included in the construct that will be transmitted alongside the driver. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/research-shows-nature-can-beat-back-scientific-tinkering-with-genes-of-entire-species/ |
10.1098/rsos.171474 | Medicine_easy_99 | Halo didn't cause Sandy Hook. | This flexibility, described as part of the 'garden of forking paths problem' increases the chance of false-positive results and serves to reduce our confidence in the inferences linking gaming to aggression . | Call of Duty didn't cause Parkland. Halo didn't cause Sandy Hook. Doom didn't cause Columbine. | First, there is a noticeable degree of flexibility in how violent game play is operationalized in survey studies. This flexibility, described as part of the 'garden of forking paths problem' increases the chance of false-positive results and serves to reduce our confidence in the inferences linking gaming to aggression . Said differently, this work depends on children and young people accurately reporting on their video game play, the level of violent content present in this play and their own trait-or state-level aggression (for an exception, see ). | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39876854667&p=1pl&v=1&x=20068Ts8P0DG-mROX7fxQA |
10.1098/rsos.171474 | Medicine_easy_100 | excessive bullying, workplace intimidation); 16% had engaged in intimate partner violence, and 11% had engaged in stalking-related conduct. | We argue that this study speaks to the key question of whether adolescents' violent video game play has a measurable effect on real-world aggressive behaviour. | For example the FBI report referenced above finds that while the 63 active shooters examined in the study couldn't be linked based on demographics alone:
62% of the shooters had a history of acting in an abusive, harassing, or oppressive way (e.g. excessive bullying, workplace intimidation); 16% had engaged in intimate partner violence, and 11% had engaged in stalking-related conduct. According to the FBI report, only 25% of active shooters between 2000 and 2013 had ever been diagnosed with mental illness. | This pattern of findings further suggests that links reported in the literature might be influenced by publication bias, selective reporting, or an artefact of unobserved or hidden moderators, as has been previously suspected . We argue that this study speaks to the key question of whether adolescents' violent video game play has a measurable effect on real-world aggressive behaviour. On the basis of our evidence, the answer is no. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39882736616&p=1pl&v=1&x=QLA1HMQhScCizGL1drmq5A |
10.1038/s41467-018-06824-8 | Medicine_easy_101 | The social bees' gene was about 15 times as active as that of the solitary bees, her team reports today in Nature Communications , making it a strong candidate for the switch to sociality. | We estimated the nucleotide diversity per site (π) to be 0.002, and we did not find differences in genetic diversity among social forms (Supplementary Table 1 ; two-sample t-test; t 4 = −0.961, p = 0.391). | "It seemed a good place to start." The social bees' gene was about 15 times as active as that of the solitary bees, her team reports today in Nature Communications , making it a strong candidate for the switch to sociality. These findings are in line with syntaxin function in other animals, Kocher says. | Whole-genome resequencing data identified a total of 2,6,960 genetic variants among 143 individuals of L. albipes that passed our quality filters (see Methods; Supplementary Data 1). We estimated the nucleotide diversity per site (π) to be 0.002, and we did not find differences in genetic diversity among social forms (Supplementary Table 1 ; two-sample t-test; t 4 = −0.961, p = 0.391). As in honey bees , LD decays rapidly with physical distance: | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37425745606&p=1pl&v=1&x=BF9poLDtNwHfjOufQy7mMA |
10.1001/jamapsychiatry.2013.4081 | Medicine_easy_102 | The study adds to a growing body of research focused on the specific effects of parental age. | Considering the broadest category of any psychiatric diagnosis (ICD-10-DCR codes F00-F99) as the outcome of interest, the offspring of the youngest mothers were at the highest risk for any mental disorders. | While older women posed increased risk only for mental retardation (which may, the authors say, reflect the well-known association between maternal age and Down syndrome), children with fathers over the age of 45 had a 34% increased risk for psychiatric illnesses overall, and showed a clear trend of steadily increasing risk over the age of 29. The study adds to a growing body of research focused on the specific effects of parental age. But it's not the first to find that an older father might make you more prone to psychiatric illness. | Overall, the cohort was followed up for 42.7 million person-years, during which 218 441 members of the cohort had their first psychiatric contact for any psychiatric disorder. Considering the broadest category of any psychiatric diagnosis (ICD-10-DCR codes F00-F99) as the outcome of interest, the offspring of the youngest mothers were at the highest risk for any mental disorders. Compared with the offspring of mothers aged 25 to 29 years, the offspring of mothers aged 12 to 19 years had a 51% increased risk of having a mental disorder (IRR, 1.51 [95% CI, 1.48-1.54]). | [1] | Medicine | train | 1 | news | http://qz.com/170543/men-shouldnt-wait-too-long-to-have-kids-either/ |
10.1001/jamaoncol.2018.3701 | Medicine_easy_103 | "This is a scenario where care is probably not beneficial and also costly--and we are putting a dollar figure on just how costly this is." | CONCLUSIONS AND RELEVANCE There is substantial cost to the Medicare program associated with the diagnosis and treatment of localized prostate cancer among elderly men in the United States, despite the fact that these men are unlikely to die of prostate cancer. | The study also showed that of the total, $451 million was spent on men who were diagnosed with prostate cancer that is graded with a Gleason score of 6, which is considered to be low-grade disease and is best managed using active surveillance rather than aggressive treatment. "This is a scenario where care is probably not beneficial and also costly--and we are putting a dollar figure on just how costly this is." Recommended Screening
The researchers said there is a wide recognition that screening for prostate cancer should stop in men at age 70. | IMPORTANCE Localized prostate cancer diagnosis and treatment among elderly men who are not likely to benefit represents a potential source of low-value health care services. CONCLUSIONS AND RELEVANCE There is substantial cost to the Medicare program associated with the diagnosis and treatment of localized prostate cancer among elderly men in the United States, despite the fact that these men are unlikely to die of prostate cancer. The majority of costs are related to treatment. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37161484598&p=1pl&v=1&x=LLy33mp4g8e_fImU9SDVlg |
10.1155/2013/783698 | Medicine_easy_104 | The study's findings, published online in the open-access journal BioMed Research International, raise important questions about the direction of current research efforts, health resource allocation and the diagnosis and treatment of infected children in India and around the world, the researchers say. | Four of 7 (57%) children with culture-confirmed TB harbored drug-resistant (DR) strains of whom 2 (50%) were multi-DR (MDR). | The study's findings, published online in the open-access journal BioMed Research International, raise important questions about the direction of current research efforts, health resource allocation and the diagnosis and treatment of infected children in India and around the world, the researchers say. "Pediatric TB is a decidedly different disease from adult TB, and our findings support the notion that childhood infections may require different prevention, diagnostic, containment and treatment tools," says lead investigator Sanjay Jain, M.D., an infectious disease specialist at the Johns Hopkins Children's Center. In nearly half of those (12) the disease had spread beyond the lungs. | Extrapulmonary disease was noted in 46%, which was predominantly meningeal. Four of 7 (57%) children with culture-confirmed TB harbored drug-resistant (DR) strains of whom 2 (50%) were multi-DR (MDR). In adjusted analyses, HIV infection, positive TST, and exposure to household smoke were found to be significantly associated with children with TB ( ≤ 0.04). | [1] | Medicine | train | 1 | news | http://www.newswise.com/articles/johns-hopkins-study-highlights-challenges-of-tuberculosis-in-children |
10.1126/scitranslmed.aan2415 | Medicine_easy_105 | They found none of the cancer-derived mutations among blood samples of 44 healthy individuals. | In principle, analysis of ctDNA has the advantage of identifying alterations that are specific to the tumor. | Among 45 breast cancer patients, the test spotted cancer-derived mutations in two of three (67 percent) patients with stage I disease, 17 of 29 (59 percent) with stage II disease and six of 13 (46 percent) with stage III cancers. They found none of the cancer-derived mutations among blood samples of 44 healthy individuals. Despite these initial promising results for early detection, the blood test needs to be validated in studies of much larger numbers of people, say the scientists. | These analyses provide a broadly applicable approach for noninvasive detection of early-stage tumors that may be useful for screening and management of patients with cancer. In principle, analysis of ctDNA has the advantage of identifying alterations that are specific to the tumor. Overall, these analyses provide information on the potential use and limitations of large-scale mutation-based measurements of ctDNA for early diagnosis in common cancers. | [1] | Medicine | train | 1 | news | http://healthmedicinet.com/news/scientists-develop-blood-test-that-spots-tumor-derived-dna-in-people-with-early-stage-cancers/ |
10.1186/s40168-015-0071-z | Medicine_easy_106 | "The types and levels of bacteria encountered by infants in developing countries is different from the types and levels of bacteria encountered by the babies in our UC Davis cohort, and that might account for some of the differences," he said. | The ecological phenomena of alternative stable community states may help explain this bimodal distribution in the infant gut. | advertisement
The researchers determined that more infants fed by secretor mothers had high levels of bifidobacteria -- 60 percent of infants versus 37.5 percent at day 6 and 80 percent versus 50 percent at day 120 -- and that infants who had more bifidobacteria had lower amounts of milk sugars left over and higher amounts of lactate in their feces. "The types and levels of bacteria encountered by infants in developing countries is different from the types and levels of bacteria encountered by the babies in our UC Davis cohort, and that might account for some of the differences," he said. Maternal secretor status is likely only one of the many factors that influence the infant gut microbiota, Lewis said. | Using this cutoff, our data also agree with the growing consensus that the establishment of bifidobacteria can happen in many infants in the first week of life . The ecological phenomena of alternative stable community states may help explain this bimodal distribution in the infant gut. Perhaps once a certain threshold of bifidobacteria/gram feces is reached the amount of SCFA and lactate produced alters the pH of the gut lumen, overcoming the buffering capacity of the luminal contents. | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2015/04/150409143035.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1038/s41598-019-40955-2 | Medicine_easy_107 | "So far, we plan to continue our 'seaweed project' in Okinawa," said Nishitsuji. | Although taxonomic classification of these brown algae should include morphological and life cycle data, the results appear to support the order Chordariales, including N. decipiens and C. okamuranus. | The Unit plans to continue sequencing samples from the Cooperative, but someday, they hope to extend their research even further. "So far, we plan to continue our 'seaweed project' in Okinawa," said Nishitsuji. "If possible, we would like to expand it to cover all of Japan." | First, molecular phylogeny using 32 mitochondrial genes showed that N. decipiens and C. okamuranus share a more recent common ancestor. Although taxonomic classification of these brown algae should include morphological and life cycle data, the results appear to support the order Chordariales, including N. decipiens and C. okamuranus. An intimate relationship between N. decipiens and C. okamuranus can also be deduced from their morphology. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38763824360&p=1pl&v=1&x=EwLVh9xrW10mzhFmqvXNkA |
10.1016/j.jpeds.2017.10.028 | Medicine_easy_108 | Temple hopes his research in identifying possible risk factors for domestic abuse may be applied to develop better intervention for children subjected to corporal punishment as they age. | Third, consistent with extant literature, female subjects were more likely to perpetrate teen dating violence than their male counterparts. | Werner-Wilson emphasized that research shows not all corporal punishment is negative, and if it is done under certain parameters, such as being conducted soon after the punishable act and being done without a strong emotional reaction from the parent, the results can be positive. Temple hopes his research in identifying possible risk factors for domestic abuse may be applied to develop better intervention for children subjected to corporal punishment as they age. "It's difficult to change our structure, our culture, and parents' behavior, but even with all that if we can affect kids through prevention programs than that would certainly be a step in the right direction," added Temple. | Second, in contrast to past research, no differences in corporal punishment were found when stratified by demographic characteristics. Third, consistent with extant literature, female subjects were more likely to perpetrate teen dating violence than their male counterparts. Notably, this latter finding refers only to acts of violence and not frequency or severity, which is important, given research showing that female subjects may suffer more long-term negative physical and psychosocial consequences of teen dating violence. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=32698329640&p=1pl&v=1&x=pR-rCOq5zncqbaREgJOeFg |
10.1073/pnas.1408439111 | Medicine_easy_110 | Accounting for variables, the team managed to create an accurate model of population density, essentially replacing the census. | Although these previously published estimates were obtained based on the number of calls or users per MP tower, rather than on the density of calls or users in a tower's covering area, similar values were expected in our analysis. | Scientists can utilize this widespread cell phone use to pinpoint cell phone tower activity, calculating the cell phone use to estimate local population density -- even in nations where a census is not taken or strongly regulated. "This is the first time people have provided statistical evidence that population data produced from cellphone records are of really good quality," said Renaud Lambiotte, an applied mathematician at the University of Namur in Belgium. Accounting for variables, the team managed to create an accurate model of population density, essentially replacing the census. | As shown in SI Appendix, section A.3, a combination of both methods further improved the accuracy of the population mapping, highlighting the complementarity of the two approaches. Although these previously published estimates were obtained based on the number of calls or users per MP tower, rather than on the density of calls or users in a tower's covering area, similar values were expected in our analysis. By using a standard cross-validation procedure in Portugal, best-fit estimates of 62.95 ± 2.48 for α and 0.803 ± 0.015 for β were found, whereas these estimations became 69.11 ± 10.49 for α and 0.767 ± 0.055 for β when using a spatially stratified crossvalidation procedure (SI Appendix, section B.2). | [1] | Medicine | train | 1 | news | http://www.inquisitr.com/1569497/scientists-have-discovered-a-way-to-take-a-census-with-cell-phones/ |
10.1038/ncomms4632 | Medicine_easy_111 | They found that the faster the nanomotor rotated, the faster it released the drugs. | No clear wear was found on the nanowire rotor (Fig. | In the near future, the Cockrell School researchers believe their nanomotors could provide a new approach to controlled biochemical drug delivery to live cells. They found that the faster the nanomotor rotated, the faster it released the drugs. "We were able to establish and control the molecule release rate by mechanical rotation, which means our nanomotor is the first of its kind for controlling the release of drugs from the surface of nanoparticles," Fan said. | 7c reveals the final Au thickness of B15 nm, reduced from its original thickness of 40 nm (Fig. No clear wear was found on the nanowire rotor (Fig. 7c) , which can be attributed to the fact that Au (Vickers hardness: 216 MPa) is much softer than Ni (Vickers hardness: 638 MPa). | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2014/05/140520123441.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.2337/dc13-1904 | Medicine_easy_112 | Cameron and his team found that 20 to 30 percent of children newly diagnosed with type 1 diabetes had DKA. | 2E) and trended lower at 6 months compared with the non-DKA group (F = 5.80, P = 0.02). | Symptoms tended to develop over time, raising a big concern for parents who might not notice any differences in their child right away. Cameron and his team found that 20 to 30 percent of children newly diagnosed with type 1 diabetes had DKA. "DKA still kills people, so we need to do better. | Gray matter MD in the frontal lobes decreased over 6 months with DKA (F = 50.23, P , 0.001) (Fig. 2E) and trended lower at 6 months compared with the non-DKA group (F = 5.80, P = 0.02). For spectroscopy, frontal gray matter NAA levels were lower at baseline in the DKA group (F = 8.73, P = 0.005) (Fig. | [1] | Medicine | train | 1 | news | http://www.medicaldaily.com/type-1-diabetes-diagnosis-may-come-brain-changes-kids-including-memory-loss-284362 |
10.1088/1741-2552/aabc9b | Medicine_easy_113 | Because adaptive deep brain stimulation did not continuously stimulate the brain, the system saved about 40 percent of the device's battery energy used during traditional stimulation. | In both patients there were energy savings without worsening of clinical symptoms. | Doctors saw and patients noticed no differences in the improvement in movement under adaptive stimulation versus constant, open loop stimulation set manually by the researchers. Because adaptive deep brain stimulation did not continuously stimulate the brain, the system saved about 40 percent of the device's battery energy used during traditional stimulation. The short time periods over which movement was assessed did not permit comparison of the two deep brain stimulation paradigms relative to incidence of dyskinesia, but it is hoped that the variable stimulation will also translate into a reduction in adverse effects when tested over longer time periods. | We have demonstrated the feasibility of adaptive DBS using a cortical detector sensitive to dyskinesia in two patients. In both patients there were energy savings without worsening of clinical symptoms. This strategy requires further testing in a chronic ambulatory setting, and may be useful in PD patients who are motor fluctuators and experience severe dyskinesia alternating with marked bradykinesia . | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34178086266&p=1pl&v=1&x=nNMoIIdQdsrnpbYA5pi8RQ |
10.1088/1741-2552/aabc9b | Medicine_easy_114 | The new method described in this study is adaptive, so that the stimulation delivered is responsive in real time to signals received from the patient's brain. | The study was registered at ClinicalTrials.gov (NCT0193296). | "The novel approach taken in this small-scale feasibility study may be an important first step in developing a more refined or personalized way for doctors to reduce the problems patients with Parkinson's disease face every day," said Nick B. Langhals, Ph.D., program director at NINDS and team lead for the BRAIN Initiative. The new method described in this study is adaptive, so that the stimulation delivered is responsive in real time to signals received from the patient's brain. The device differs from traditional ones in that it can both monitor and modulate brain activity. | Since this signature of dyskinesia is not disrupted by voluntary movement and occurs in a predictable frequency range, it is a promising control signal for adaptive DBS. The study was registered at ClinicalTrials.gov (NCT0193296). Because Activa PC+S was only implanted unilaterally, adaptive DBS was delivered only on one side. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34178086266&p=1pl&v=1&x=nNMoIIdQdsrnpbYA5pi8RQ |
10.1098/rsos.171474 | Medicine_easy_115 | The registered study approach is a safe-guard against this," says Przybylski. | In fact, we observed at least three such correlations ranging in size from when considering uncorrected models using variables we did not hypothesize would be correlated with aggressive behaviour. | A cherry-picked result can add undue weight to the moral panic surrounding video games. The registered study approach is a safe-guard against this," says Przybylski. While no correlation was found between playing video games and aggressive behavior in teenagers, the researchers emphasize that this does not mean that some mechanics and situations in gaming do not provoke angry feelings or reactions in players. | Further, this is not to say that we could rule out a correlation between every operationalization of gaming and every measure of adolescents' violent behaviour. In fact, we observed at least three such correlations ranging in size from when considering uncorrected models using variables we did not hypothesize would be correlated with aggressive behaviour. For example, our positive control check question, a simple 5-point Likert scale that asked participants to rate their own intensity of engagement with games happened to be positively correlated (r ¼ 0.25) to aggressive behaviour. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38630667262&p=1pl&v=1&x=eg7bkQTzSVqLm5ru549FjQ |
10.1111/cdev.12250 | Medicine_easy_118 | "We suspect they may have then engaged in more and more extreme behaviors trying to gain peer approval," Allen said. | This constellation will be linked to greater peer popularity in the short term, but this link will fade as adolescence progresses and peers mature. | And as the cohort got older, these mature behaviors got a forceful shove into full-blown recklessness. "We suspect they may have then engaged in more and more extreme behaviors trying to gain peer approval," Allen said. In other words, "those who got approval for drinking at 13 had to get wasted multiple times and engage in more extreme acts to try, unsuccessfully, to gain approval in later years." | A constellation of behaviors-minor delinquent activity, precocious romantic involvement, and a focus on physical appearance in friendships -will each be linked to early adolescents' strong desire for status among peers. This constellation will be linked to greater peer popularity in the short term, but this link will fade as adolescence progresses and peers mature. 3. | [1] | Medicine | train | 1 | news | http://www.medicaldaily.com/cool-kids-grow-be-adult-burnouts-how-early-popularity-can-kill-childs-future-287922 |
10.1093/molbev/msu227 | Medicine_easy_119 | They also identified genomic hotspots that seem to play a key role in adaptation and survival, with many having an unknown function. | As we do not observe a dominance of intraspecies clustering in the phylogenetic analysis, these gene families are not evolving in a fashion as would be predicted via concerted evolution. | They found an extensive and robust shuffling of the genomic deck between chlamydia families has played a major role in the evolution of the pathogen, often serving to outwit and exploit its hosts. They also identified genomic hotspots that seem to play a key role in adaptation and survival, with many having an unknown function. Of note, these gene families were most commonly found to have specific protein features gained from their eukaryotic hosts. | S2-S6, Supplementary Material online). As we do not observe a dominance of intraspecies clustering in the phylogenetic analysis, these gene families are not evolving in a fashion as would be predicted via concerted evolution. We provide clear evidence supporting birth-and-death evolution of the PEX and NEX gene families, which is marked by independent gains and losses of members . | [1] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2014/10/141014085130.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.2337/db13-1600 | Medicine_easy_120 | The researchers also confirmed that the spinal cord is the actual physical route by which information from the portal vein travels to the hindbrain, overturning the previous belief that it was transmitted via the vagus nerve. | This would further explain why clamping either portal-mesenteric or brain glycemia during general systemic hypoglycemia is equally effective in blunting the CRR . | "But neurons in the hindbrain continue to respond to fast onset hypoglycemia even in the absence of peripheral sensors." The researchers also confirmed that the spinal cord is the actual physical route by which information from the portal vein travels to the hindbrain, overturning the previous belief that it was transmitted via the vagus nerve. "But it's absolutely essential in slow onset hypoglycemia." | In this capacity, central glucose sensors might also act primarily to suppress CRRs once euglycemia is reestablished following a hypoglycemic event. This would further explain why clamping either portal-mesenteric or brain glycemia during general systemic hypoglycemia is equally effective in blunting the CRR . What is clear from experiment 3 is that the brain can defend itself against large, rapid declines in blood glucose without portal-mesenteric glucose sensory input. | [1] | Medicine | train | 1 | news | http://www.healthcanal.com/metabolic-problems/diabetes/49962-diabetes-detectives.html |
10.1210/en.2015-2036 | Medicine_easy_121 | Vitamin D and ID1 expression
The researchers found that the 4T1 cell line expresses significantly lower levels of the vitamin D receptor protein. | These results confirmed the in vivo BLI signal data that the VDR KD tumors were substantially larger than control and VDR Rescue tumors. | Mice fed a diet deficient in vitamin D developed palpable tumors an average of seven days sooner than their peers, and after six weeks of growth those tumors were significantly larger in size than those in animals with adequate vitamin D levels. Vitamin D and ID1 expression
The researchers found that the 4T1 cell line expresses significantly lower levels of the vitamin D receptor protein. When they genetically engineered 168FARN cells to also have lower-than-normal levels of the VDR protein, the cells began to behave much more like the 4T1 cells. | This striking pattern remained consistent until the endpoint of the study when the mice with VDR KD tumors needed to be euthanized for morbidity ( Figure 2B ). These results confirmed the in vivo BLI signal data that the VDR KD tumors were substantially larger than control and VDR Rescue tumors. Remarkably, ex vivo BLI imaging ( Figure 2E ) and direct histology (Supplemental Figure 3) revealed that 60% of the mice with VDR KD tumors had metastatic spread to the liver. | [1] | Medicine | train | 1 | news | http://www.science20.com/news_articles/vitamin_d_deficiency_contributes_to_spread_of_breast_cancer_in_mice_stanford_study_finds-167109 |
10.1001/jamainternmed.2016.0157 | Medicine_easy_122 | Forty-five (53%) participants reported having hypertension, 41 (91%) of whom reported taking antihypertensive medications. | Results | Of 85 participants, 44 (52%) were women. | Of the remaining 85 participants, 44 (52%) were women, mean age (SD) was 56.6 (16.3) years, body mass index was 27.8 (5.8). Forty-five (53%) participants reported having hypertension, 41 (91%) of whom reported taking antihypertensive medications. The difference between IBP and standard measurements were 12.4 (SD 10.5) mm Hg for systolic BP and 10.1 (SD 8.1) mm Hg for diastolic BP. | Per prespecified dropping rules, data from 16 individuals were discarded because of unavailable cuff sizes (n = 1), standard device errors (n = 2), and excessive variation in sequential standard BP measurements, greater than 12 mm Hg for systolic BP or greater than 8 mm Hg for diastolic BP (n = 1). Results | Of 85 participants, 44 (52%) were women. Their mean (SD) age was 56.6 (16.3) years, and their body mass index, calculated as weight in kilograms divided by height in meters squared, was 27.8 (5.8); 45 (53%) self-reported hypertension, and 91% of these (41) reported taking antihypertensive medications. | [1] | Medicine | train | 1 | news | http://www.oncologynurseadvisor.com/instant-blood-pressure-mobile-app-fails-validation-study/article/484459/ |
10.1001/jamaoncol.2018.3701 | Medicine_easy_123 | "The SelectMDx biomarker offers physicians and patients an easily obtained urine-based test, which combines cost effectiveness with clinical utility, improving urologists' ability to diagnose and treat prostate cancer." | Comparing SEER agespecific rates between the 2007-2011 and 2009-2013 periods, all age groups experienced a decline in incidence of prostate cancer. | "These data further demonstrate the importance of adjunctive biomarkers regarding PSA assessment, especially regarding the decision to either avoid or to proceed to prostate biopsy," said principal investigator Neal Shore , M.D., Medical Director at the Carolina Urologic Research Center , Atlantic Urology Clinics in Myrtle Beach, South Carolina. "The SelectMDx biomarker offers physicians and patients an easily obtained urine-based test, which combines cost effectiveness with clinical utility, improving urologists' ability to diagnose and treat prostate cancer." SelectMDx was shown to have a significant impact on initial prostate biopsy decision-making. | These men have less than a 10-year life expectancy and are the least likely to benefit from prostate cancer screening; they are more likely to die from a comorbid illness than from prostate cancer. Comparing SEER agespecific rates between the 2007-2011 and 2009-2013 periods, all age groups experienced a decline in incidence of prostate cancer. 29, 30 The age groups with the largest declines were ages 70 to 74 years (a decrease of 112 men per 100 000) and 75 to 79 years (a decrease of 120 men per 100 000). | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37616037423&p=1pl&v=1&x=gXp7O7pmGkPY1w04wbVK7A |
10.1038/s41467-019-09863-x | Medicine_easy_124 | But they are considerably lower for these scenarios compared to business as usual," said Yumashev. | The dynamic model formulation employed here contains the following layers of nonlinearity: nonlinear response of the equilibrium cumulative carbon to GMST changes, represented by the ωφ ω (T)·T term; evolution of the characteristic time lag for cumulative permafrost emissions with the difference between the equilibrium and realised cumulative carbon, represented by p (in the corresponding linear model p = 0 and the lag is simply equal to τ); temperature-dependence in the lag and power parameters, represented by φ τ , φ p ; and, saturation of the cumulative carbon emissions due to the permafrost carbon stock exhaustion, represented by C max . | "Even at 1.5degC to 2degC [warming], there are impacts and costs due to thawing permafrost. But they are considerably lower for these scenarios compared to business as usual," said Yumashev. "The most important thing to remember about our study is the greater the warming, the stronger the feedbacks and the higher the costs to society." | The pursuit curve model ensures that there is an equilibrium level of cumulative carbon emissions from permafrost for any given level of warming globally (providing p > −1). The dynamic model formulation employed here contains the following layers of nonlinearity: nonlinear response of the equilibrium cumulative carbon to GMST changes, represented by the ωφ ω (T)·T term; evolution of the characteristic time lag for cumulative permafrost emissions with the difference between the equilibrium and realised cumulative carbon, represented by p (in the corresponding linear model p = 0 and the lag is simply equal to τ); temperature-dependence in the lag and power parameters, represented by φ τ , φ p ; and, saturation of the cumulative carbon emissions due to the permafrost carbon stock exhaustion, represented by C max . 7 under the range of scenarios considered. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39059198716&p=1pl&v=1&x=LFeOjGrAvD1wF12D7W6Wvg |
10.1001/jamapsychiatry.2018.1941 | Medicine_easy_125 | "These findings provide a neural basis for understanding how depression relates to poor sleep quality, and this in turn has implications for treatment of depression and improvement of sleep quality because of the brain areas identified." | Many significantly correlated links involved the precuneus, the anterior cingulate cortex, the lateral orbitofrontal cortex, the hippocampus and parahippocampal cortex, and some motor areas ( Figure 2 ; eFigure 2 in the Supplement). | Researchers believe it is the first time the neural mechanisms underlying the association of depression and sleep have been studied in a large sample. "These findings provide a neural basis for understanding how depression relates to poor sleep quality, and this in turn has implications for treatment of depression and improvement of sleep quality because of the brain areas identified." "This study may also have implications for a deeper understanding of depression," he said. | All links that are correlated with the PSQI score are shown in Figure 2 . Many significantly correlated links involved the precuneus, the anterior cingulate cortex, the lateral orbitofrontal cortex, the hippocampus and parahippocampal cortex, and some motor areas ( Figure 2 ; eFigure 2 in the Supplement). The correlation between the sleep quality and the mean strength of these significant functional connectivities is shown in Figure 1A (r = 0.181; P =6. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34634204738&p=1pl&v=1&x=GZ7D3xt9Fp7_9IgR9S1Qrg |
10.1111/1365-2656.12871 | Medicine_easy_126 | It is no longer a case of which disease is a better control agent, because their effectiveness is intrinsically linked." | Where, in this instance, we were able to model directly the effect of disease status of individual rabbits on survival, using a larger number of individuals, without assuming discrete periods for RHD epizootics. | Our study shows the first evidence that both viruses work in tandem to control rabbit population numbers. It is no longer a case of which disease is a better control agent, because their effectiveness is intrinsically linked." "The effect of RHDV disease virus on rabbits is enhanced by previous infection with MYXV virus. | This is likely to reflect differences in the two approaches used to analyse the data. Where, in this instance, we were able to model directly the effect of disease status of individual rabbits on survival, using a larger number of individuals, without assuming discrete periods for RHD epizootics. Our finding that RHDV can persist at low levels across the year is independently supported by relatively short-lived immunoglobulin M (IgM), being detected (at titres ≥40) in low numbers of rabbits throughout the year (Supporting Information Figure S10 ). | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34506942217&p=1pl&v=1&x=OCP5j07SbNKK_Tx7JPH1Dw |
10.1073/pnas.1505114112 | Medicine_easy_128 | But perhaps the best benefit to musical training, Kraus found, was that the developmental outcomes strengthened the brain well enough to stall cognitive decline later in life. | Response consistency peaks in childhood (∼8-11 y of age), declining steadily until young adulthood ; we show that this adolescent decline is mitigated by in-school music lessons. | The findings have important implications for teens in low-income neighborhoods, as their language development is often below that of their wealthier counterparts. But perhaps the best benefit to musical training, Kraus found, was that the developmental outcomes strengthened the brain well enough to stall cognitive decline later in life. Source: Tierney A, Krizman J, Kraus N. Music training alters the course of adolescent auditory development. | The consistency of neural responses to sound tracks with language skills, suggesting that stable perceptual encoding is vital for the acquisition and maintenance of phonological categories . Response consistency peaks in childhood (∼8-11 y of age), declining steadily until young adulthood ; we show that this adolescent decline is mitigated by in-school music lessons. Synaptic density follows a similar developmental trajectory, increasing in early childhood and subsequently declining during adolescence (2-5). | [1] | Medicine | train | 1 | news | http://www.medicaldaily.com/taking-music-class-high-school-improves-teen-language-skills-may-boost-academic-344674 |
10.1002/ejhf.69 | Medicine_easy_129 | Heart failure hospitalizations are associated with a poor prognosis irrespective of whether the hospitalization occurred in patients without heart failure or in a patient with previously diagnosed heart failure, or whether the patient has reduced or preserved ejection fraction. | HF with preserved ejection fraction was more common in participants without vascular disease (67.0% vs. 55.0%, P=0.040). | "I say it really does not matter. Heart failure hospitalizations are associated with a poor prognosis irrespective of whether the hospitalization occurred in patients without heart failure or in a patient with previously diagnosed heart failure, or whether the patient has reduced or preserved ejection fraction. The data include new-onset HF in both inpatient and outpatient settings. | There was no significant difference in hospitalizations between those with and without vascular disease (RR 1.04 95%CI: 0.86-1.24 for all-cause, and RR 0.84 95%CI 0.69-1.02 for HF hospitalization). HF with preserved ejection fraction was more common in participants without vascular disease (67.0% vs. 55.0%, P=0.040). Conclusion-A significant proportion of HF in older adults develops without prior vascular disease. | [1] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38228224591&p=1pl&v=1&x=VEvBLGqbB4NvvfbrYC9-sA |