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10.1111/j.1360-0443.2010.02899.x | Medicine_tweet_261 | RT @username: Relation between Different Dimensions of #Alcohol Consumption & Burden of Disease - An Overview | The variation in the effect of alcohol consumption on different types of stroke may be ascribed to the difference in the causes of haemorrhagic and ischaemic stroke. | RT @username: Relation between Different Dimensions of #Alcohol Consumption & Burden of Disease - An Overview | According to these meta-analyses, low to moderate alcohol consumption (one to two drinks per day) seemed to have a protective effect on ischaemic stroke, and then the risk curve turned upwards. The variation in the effect of alcohol consumption on different types of stroke may be ascribed to the difference in the causes of haemorrhagic and ischaemic stroke. Consequently, a pattern of irregular heavy drinking occasions should also have the same detrimental effects as for IHD. | [3.0, 2.0, 3.0, 3.0] | Medicine | train | 2.75 | tweets | 193584254939176960 |
10.1001/jama.2013.276302 | Medicine_tweet_262 | Controversies about Accountable Care Organizations ACO lower spending ..but not with consistently improved quality | Additional efforts to foster multipayer participation in global payment systems, such as recent state initiatives and provisions in Pioneer Medicare ACO contracts, 15,32,33 may be important. | Controversies about Accountable Care Organizations ACO lower spending ..but not with consistently improved quality | Conversely, cost-reducing spillovers present a free-riding problem to commercial insurers engaged in ACO contracts, since competing insurers with similar provider networks could offer lower premiums without incurring the costs of managing an ACO. Additional efforts to foster multipayer participation in global payment systems, such as recent state initiatives and provisions in Pioneer Medicare ACO contracts, 15,32,33 may be important. Our study had several limitations. | [3.0, 1.0, 4.0, 1.0, 1.0] | Medicine | train | 1 | tweets | 372694073179529216 |
10.1186/s13601-015-0055-x | Medicine_tweet_263 | @username @username Latest Canadian study of where accidental exposures occur says this too. | Consequently, more education is required on the importance of strict allergen avoidance and the need for prompt and correct management of anaphylaxis. | @username @username Latest Canadian study of where accidental exposures occur says this too. | Conclusion: Despite increased awareness, accidental exposures continue to occur, mainly at home, and most are managed inappropriately by both health care professionals and caregivers. Consequently, more education is required on the importance of strict allergen avoidance and the need for prompt and correct management of anaphylaxis. Potential predictors for the Cox regression included sex, ethnicity, age at study entry, disease duration, source of recruitment (i.e., food allergy advocacy associations versus allergy clinics), other atopic conditions, severity of initial reaction to peanut, whether the child attended a school prohibiting peanut, and parental factors (i.e., living arrangement, age, level of education and employment). | [1.0, 1.0, 2.0, 1.0] | Medicine | train | 1.25 | tweets | 586156349496684544 |
10.1038/s41467-018-04133-8 | Medicine_tweet_264 | Congratulations Giancarlo for this really interesting paper! Unexpected behaviors in molecular transport through size-controlled #nanochannels down to the ultra-#nanoscale
@username @username @username @username #researchimpactEU | It is important to note that obtaining a linear release profile for a molecule carrying a charge of sign opposite to that of the channel surfaces is trivial: as a matter of fact, it is a previously unreported achievement. | Congratulations Giancarlo for this really interesting paper! Unexpected behaviors in molecular transport through size-controlled #nanochannels down to the ultra-#nanoscale
@username @username @username @username #researchimpactEU | 3 and Supplementary Fig. It is important to note that obtaining a linear release profile for a molecule carrying a charge of sign opposite to that of the channel surfaces is trivial: as a matter of fact, it is a previously unreported achievement. Figure 2b exhibits release curves of anionic cefazolin, (3-aminosalicylic acid in Supplementary Fig. | [1.0, 2.0, 1.0, 1.0, 3.0] | Medicine | train | 1.6 | tweets | 996674391961415680 |
10.1016/j.cell.2015.10.069 | Medicine_tweet_265 | Yeast can adapt to deletion of many essential genes; 'essentiality' may need to be redefined as a spectrum: | In particular, evolvable genes were enriched for components of subcellular compartments found only in eukaryotes (nucleus, endoplasmic reticulum, Golgi apparatus), but lacked core machineries common to all known cellular systems (mediators of DNA, mRNA and protein synthesis). | Yeast can adapt to deletion of many essential genes; 'essentiality' may need to be redefined as a spectrum: | Our data also pointed toward specific cellular functions being more evolvable than others. In particular, evolvable genes were enriched for components of subcellular compartments found only in eukaryotes (nucleus, endoplasmic reticulum, Golgi apparatus), but lacked core machineries common to all known cellular systems (mediators of DNA, mRNA and protein synthesis). This finding might imply that while some core functions are so central to cell survival as to prevent major evolutionary changes, it is possible that evolutionarily ''younger'' essential genes might have retained a certain degree of evolvability. | [2.0, 1.0, 2.0, 1.0, 4.0] | Medicine | train | 2 | tweets | 671449802937380868 |
10.1073/pnas.1424293112 | Medicine_tweet_266 | .@username on pathogenic fungus on BC poplars. | Most of the M. populorum secondary metabolite cluster proteins were found nested within a group of Eurotiomycetes fungi, including P. oxalicum, as expected under the hypothesis that the cluster was transferred from a Eurotiomycetes ancestor through a horizontal transfer event ( Fig. | .@username on pathogenic fungus on BC poplars. | The striking conservation in synteny and gene sequence as well as the sporadic distribution of the full cluster in only two groups of the fungal phylogeny (Dothideomycetes and Eurotiales) raises the possibility that this cluster was acquired through horizontal gene transfer (HGT) (Fig. Most of the M. populorum secondary metabolite cluster proteins were found nested within a group of Eurotiomycetes fungi, including P. oxalicum, as expected under the hypothesis that the cluster was transferred from a Eurotiomycetes ancestor through a horizontal transfer event ( Fig. 2B ; Dataset S2; SI Appendix, Origin and evolutionary history of the chaetoglobosin-like gene cluster in M. populorum). | [1.0, 2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.2 | tweets | 573359896764145664 |
10.1186/s40479-014-0023-4 | Medicine_tweet_267 | Sleep and BPD
| Future studies should concentrate on ambulatory polysomnographic recordings to investigate sleep in natural environments to detect sleep and dream complaints in people with nightmares. | Sleep and BPD
| Therefore, nightmares should be seen as a distinct sleep disorder with specific symptoms that needs specific treatment. Future studies should concentrate on ambulatory polysomnographic recordings to investigate sleep in natural environments to detect sleep and dream complaints in people with nightmares. Furthermore, the difference between nightmare distress and nightmare frequency should be regarded which may lead to new insights concerning objective sleep measures. | [1.0, 3.0, 1.0, 1.0, 1.0] | Medicine | train | 1.4 | tweets | 833963484970901504 |
10.1038/s41591-018-0013-y | Medicine_tweet_268 | Supporting brilliant Jose Vicente Sanchez-Mut @username to describe a new quantitative trait locus associated with Alzheimer’s disease. #meQTL #Alzheimer #GWAS. NOW OUT @username.
| These findings suggest that in a particular genetic background, PM20D1 contributes to neuroprotection against AD. | Supporting brilliant Jose Vicente Sanchez-Mut @username to describe a new quantitative trait locus associated with Alzheimer’s disease. #meQTL #Alzheimer #GWAS. NOW OUT @username.
| In line, genetically increasing or decreasing the expression of PM20D1 reduces and aggravates AD-related pathologies, respectively. These findings suggest that in a particular genetic background, PM20D1 contributes to neuroprotection against AD. When we re-analyzed these biologically and technically independent datasets by focusing exclusively on the comparison between samples from healthy controls and patients with advanced-stage AD, we noted that only one gene, PM20D1, which was previously described as a mQTL , consistently displayed promoter hypermethylation in patients with AD (hereafter referred to as AD samples) than in healthy controls in both studies (Fig. | [2.0, 3.0, 4.0] | Medicine | train | 3 | tweets | 993748033690046464 |
10.1001/jamaophthalmol.2017.5470 | Medicine_tweet_269 | Study suggests #opticneuritis overdiagnosed in >50% of cases and evaluates where diagnostic process might go wrong. | The most common diagnostic error was eliciting or interpreting critical elements of history, which occurred in 24 of 73 patients (33%) with alternative diagnoses. | Study suggests #opticneuritis overdiagnosed in >50% of cases and evaluates where diagnostic process might go wrong. | The most common alternative diagnoses were headache and eye pain, functional visual loss, and other optic neuropathies, particularly nonarteritic anterior ischemic optic neuropathy. The most common diagnostic error was eliciting or interpreting critical elements of history, which occurred in 24 of 73 patients (33%) with alternative diagnoses. Other common errors included errors weighing or considering alternative diagnoses (23 patients [32%]), errors weighing or interpreting physical examination findings (15 patients [21%]), and misinterpreting diagnostic test results (11 patients [15%]). | [2.0, 3.0, 2.0, 3.0, 4.0] | Medicine | train | 2.8 | tweets | 939540144989851649 |
10.1073/pnas.1323342111 | Medicine_tweet_27 | Amygdala encodes subjective judgment of emotions shown in face stimuli, rather than simply their stimulus features: | This suggests that amygdala neurons encode whole-face information and emotion independently. | Amygdala encodes subjective judgment of emotions shown in face stimuli, rather than simply their stimulus features: | We found 3 out of 24 (12.5%) fear-selective cells and 5 out of 17 (29.4%) happyselective cells are also whole-face-selective, a ratio of whole-face cells similar to that found in the entire population (36 out of 185, 19.5%). This suggests that amygdala neurons encode whole-face information and emotion independently. We found that face information conveyed by the eyes, but not the mouth region, modulated emotion-selective neuronal responses. | [4.0, 5.0, 5.0, 4.0, 4.0] | Medicine | train | 4.4 | tweets | 535386739956006912 |
10.1016/j.ijnurstu.2014.02.007 | Medicine_tweet_272 | @username The only research I know in this area is on critical care & level 1 trauma centres but not much. | We found no evidence that the number of support staff working on the unit improves patients' survival chances even though their presence on the unit might have the effect of releasing clinical staff to care for patients. | @username The only research I know in this area is on critical care & level 1 trauma centres but not much. | Nurses and doctors do seem to make a difference to patient outcomes in ICU. We found no evidence that the number of support staff working on the unit improves patients' survival chances even though their presence on the unit might have the effect of releasing clinical staff to care for patients. In this study, clear support emerged for the effect of workload. | [2.0, 1.0, 2.0, 3.0, 1.0] | Medicine | train | 1.8 | tweets | 620479212097548288 |
10.1126/science.aap7778 | Medicine_tweet_273 | WHY these behavioral progressions of H. sapiens emerged in the Glacial Maximum?
1) Oldest known evidence for BOW-ARROW dated to ~62,000 years in S. Africa
2) Oldest known CAVE PAINTINGS dated to ~65,000 years in W. Europe
| The implication is, therefore, that the artists were Neandertals. | WHY these behavioral progressions of H. sapiens emerged in the Glacial Maximum?
1) Oldest known evidence for BOW-ARROW dated to ~62,000 years in S. Africa
2) Oldest known CAVE PAINTINGS dated to ~65,000 years in W. Europe
| In this age range, Iberia was exclusively populated by Neandertals, as indicated by numerous diagnostic osteological remains, including articulated skeletons (28, 29) . The implication is, therefore, that the artists were Neandertals. This is a 1 cm 5 cm restricted and nonfigurative set of subjects and could represent the extension of Neandertal body art to the external world. | [1.0, 2.0, 3.0] | Medicine | train | 2 | tweets | 989516975188664321 |
10.1001/jama.2009.1943 | Medicine_tweet_274 | @username Here is a link to one of the studies we cite: | The present findings indicate that the efficacy of ADM treatment for depression varies considerably as a function of symptom severity. | @username Here is a link to one of the studies we cite: | Specific contrasts revealed that the regression coefficient (i.e., the slope representing the relationship between initial severity and change in symptoms) was more positive for each medication class relative to placebo: imipramine, F(1,707)=5.60, p=0.02; and paroxetine, F(1,707)=5.91, p=0.02. The present findings indicate that the efficacy of ADM treatment for depression varies considerably as a function of symptom severity. "True" drug effects (an advantage of ADM over placebo) were nonexistent-to-negligible among depressed patients with mild, moderate, and severe baseline symptoms, whereas they were large for patients with very-severe symptoms. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | tweets | 94488214106144769 |
10.1038/s41598-017-18618-x | Medicine_tweet_275 | Apple cider vinegar has multiple antimicrobial properties on different microbial species, affecting microbe growth, suppressing mononuclear cytokine and phagocytic responses | The minimum dilution of ACV required for growth inhibition varied for each microbial species. | Apple cider vinegar has multiple antimicrobial properties on different microbial species, affecting microbe growth, suppressing mononuclear cytokine and phagocytic responses | The minimum dilution of ACV required for growth inhibition varied for each microbial species. For C. albicans, a 1/2 ACV had the strongest effect, S. aureus, a 1/25 dilution ACV was required, whereas for E-coli cultures, a 1/50 ACV dilution was required (p < 0.05). Monocyte co-culture with microbes alongside ACV resulted in dose dependent downregulation of inflammatory cytokines (TNFα, IL-6). | [2.0, 3.0, 2.0, 2.0, 1.0] | Medicine | train | 2 | tweets | 1022411479558094848 |
10.1377/hlthaff.2014.1428 | Medicine_tweet_276 | Some state vaccination laws contribute to greater exemption rates and disease outbreaks in the US -- @username | Thus, their scores on the index-which assesses the effectiveness of both nonmedical and medical exemption policies-would not be accurate, and they are not included in any of the four quartiles. | Some state vaccination laws contribute to greater exemption rates and disease outbreaks in the US -- @username | Another component associated with lower exemption rates was the ability to be exempt from text) . Thus, their scores on the index-which assesses the effectiveness of both nonmedical and medical exemption policies-would not be accurate, and they are not included in any of the four quartiles. This reduced exemption rates by 0.7 percent (Exhibit 3). | [2.0, 2.0, 1.0, 1.0] | Medicine | train | 1.5 | tweets | 628571140647219201 |
10.1038/s41379-019-0249-1 | Medicine_tweet_279 | @username @username @username It's an area of active research, but the numbers are small.
See e.g.
Note they used both an L1 test (SPF) *and* a p16 test to protect against false negatives caused by viral genome integration that drops the L1 gene. (An e6/e7 test would be good too.) | HPV-negative tumors were more frequently of the non-squamous type (9/21, 43% vs. 37/193, 19%; p < 0.01) and showed negative p16 staining (9/21; 43% vs. 7/193; 4%; p < 0.01). | @username @username @username It's an area of active research, but the numbers are small.
See e.g.
Note they used both an L1 test (SPF) *and* a p16 test to protect against false negatives caused by viral genome integration that drops the L1 gene. (An e6/e7 test would be good too.) | Twenty-one out of 214 tumors (10%) were negative for HPV DNA. HPV-negative tumors were more frequently of the non-squamous type (9/21, 43% vs. 37/193, 19%; p < 0.01) and showed negative p16 staining (9/21; 43% vs. 7/193; 4%; p < 0.01). HPV-negative tumors were more frequently diagnosed at advanced FIGO stage (19/21, 91% vs. 110/193, 57%; p < 0.01) and more frequently had lymph node metastases (14/21, 67% vs. 69/193, 36%; p < 0.01). | [2.0, 3.0, 2.0, 1.0, 1.0] | Medicine | train | 1.8 | tweets | 1112854810674384896 |
10.1111/acer.12656 | Medicine_tweet_28 | Lower results on IQ tests are associated with higher consumption of alcohol. | They found a J-shaped association between frequency of drinking and IQ test results, where the daily drinkers had the lowest IQ. | Lower results on IQ tests are associated with higher consumption of alcohol. | It should be noted that the authors report a skewed study population with regard to low socioeconomic position . They found a J-shaped association between frequency of drinking and IQ test results, where the daily drinkers had the lowest IQ. A higher IQ was associated with being a rare, an occasional, and a moderate drinker, whereas there was a lower IQ for being a former drinker compared with being a lifetime abstainer. | [5.0, 5.0, 5.0, 5.0, 5.0] | Medicine | train | 5 | tweets | 569886674550964225 |
10.1007/s00401-017-1680-3 | Medicine_tweet_280 | Open Access UCL Research: Mixed pathologies including chronic traumatic encephalopathy account for dementia in ... | The findings of multiple foci of tau-positive ATs and NFTs with more intense in the sulcal depths of the frontal and temporal cortices with a perivascular distribution were diagnostic of CTE . | Open Access UCL Research: Mixed pathologies including chronic traumatic encephalopathy account for dementia in ... | Examination of the brain showed moderate atrophy of the temporal lobes and hippocampi and fenestration of the septum pellucidum, with no evidence of metastatic tumour. The findings of multiple foci of tau-positive ATs and NFTs with more intense in the sulcal depths of the frontal and temporal cortices with a perivascular distribution were diagnostic of CTE . In addition, there was widespread tau pathology supportive of CTE with neuronal and glial inclusions in the superficial cortical layers. | [2.0, 4.0, 2.0, 1.0] | Medicine | train | 2.25 | tweets | 851466787560542208 |
10.1542/peds.2014-2707 | Medicine_tweet_281 | The Great Sleep Recession Maybe some quantitative easing required? | Cohort effects were also observed for some subgroups, particularly in $7 hours of sleep for male subjects, white subjects, and those in urban areas; those in the earliest cohorts, as well as cohorts born in the early 1990s, were more likely to report regular $7 hours of sleep compared with all other adolescents. | The Great Sleep Recession Maybe some quantitative easing required? | Thus, these data indicate that adolescent sleep is declining across all age groups and major sociodemographic subgroups. Cohort effects were also observed for some subgroups, particularly in $7 hours of sleep for male subjects, white subjects, and those in urban areas; those in the earliest cohorts, as well as cohorts born in the early 1990s, were more likely to report regular $7 hours of sleep compared with all other adolescents. Third, we documented that girls are less likely to regularly report $7 hours of sleep and to feel they get adequate sleep, as are black/Hispanic adolescents and those in lower SES strata. | [1.0, 2.0, 2.0, 3.0] | Medicine | train | 2 | tweets | 567235990394523648 |
10.1073/pnas.1313039111 | Medicine_tweet_282 | The power of crowd-sourcing: My favorite hobby, folding RNA,...done by 37,000 people. | These results show that an online community can carry out large-scale experiments, hypothesis generation, and algorithm design to create practical advances in empirical science. | The power of crowd-sourcing: My favorite hobby, folding RNA,...done by 37,000 people. | These rules, distilled by machine learning into a new automated algorithm EteRNABot, also significantly outperform prior algorithms in a gauntlet of independent tests. These results show that an online community can carry out large-scale experiments, hypothesis generation, and algorithm design to create practical advances in empirical science. The initial 6-mo training period, called phase I, saw the EteRNA community engaging in six RNA design problems containing increasing numbers of nonhelical elements (bulges and multihelix junctions) and more complex topologies ( Fig. | [2.0, 1.0, 2.0, 3.0] | Medicine | train | 2 | tweets | 428926849721184256 |
10.1073/pnas.1408439111 | Medicine_tweet_285 | New research on @username dynamic population mapping: and video: by @username et al. | This study demonstrates how data collected by mobile phone network operators can costeffectively provide accurate and detailed maps of population distribution over national scales and any time period while guaranteeing phone users' privacy. | New research on @username dynamic population mapping: and video: by @username et al. | The global MP penetration Significance Knowing where people are is critical for accurate impact assessments and intervention planning, particularly those focused on population health, food security, climate change, conflicts, and natural disasters. This study demonstrates how data collected by mobile phone network operators can costeffectively provide accurate and detailed maps of population distribution over national scales and any time period while guaranteeing phone users' privacy. The methods outlined may be applied to estimate human population densities in lowincome countries where data on population distributions may be scarce, outdated, and unreliable, or to estimate temporal variations in population density. | [1.0, 3.0, 1.0, 1.0] | Medicine | train | 1.5 | tweets | 527035715730046976 |
10.1002/pon.4156 | Medicine_tweet_286 | Exercise improves memory in breast cancer survivors
New study: | Finally, higher levels of distress (β = À0.31) and fatigue (β = À0.18) were associated with lower Frequency of Forgetting scores which is indicative of greater SMI. | Exercise improves memory in breast cancer survivors
New study: | Survivors who reported higher levels of distress also reported higher levels of fatigue (β = 0.63). Finally, higher levels of distress (β = À0.31) and fatigue (β = À0.18) were associated with lower Frequency of Forgetting scores which is indicative of greater SMI. Additionally, the indirect paths from physical activity to SMI via exercise self-efficacy and distress, exercise self-efficacy and fatigue and exercise selfefficacy, distress and fatigue were all significant. | [4.0, 1.0, 2.0] | Medicine | train | 2 | tweets | 751688955070976000 |
10.1542/peds.2013-3406 | Medicine_tweet_287 | Prenatal SSRIs might increase susceptibility to #autism or developmental delays, but findings are inconsistent. (£) | Adjusting, rather than restricting, for maternal mental health yielded similar findings. | Prenatal SSRIs might increase susceptibility to #autism or developmental delays, but findings are inconsistent. (£) | The pattern was similar among boys in the anxiety/mood disorder subset, but with low precision (102 ASD, 29 DD, 50 TD). Adjusting, rather than restricting, for maternal mental health yielded similar findings. Results were similar, although attenuated. | [1.0, 3.0, 1.0, 2.0, 1.0] | Medicine | train | 1.6 | tweets | 455744735857352704 |
10.1098/rspb.2013.1698 | Medicine_tweet_288 | Lab is starting to do sleep work: here we link perceptual consolidation with processes usually associated with memory | The average time spent in REM was negatively correlated with SWS duration, which, in turn, can explain the negative correlation that was found for SWS duration and adaptation and for low-frequency power in the delta and theta range and adaptation. | Lab is starting to do sleep work: here we link perceptual consolidation with processes usually associated with memory | Participants who exhibited high amounts of REM sleep also showed greater adaptation. The average time spent in REM was negatively correlated with SWS duration, which, in turn, can explain the negative correlation that was found for SWS duration and adaptation and for low-frequency power in the delta and theta range and adaptation. Adaptation was further predicted by spindle density of both slow and fast spindles, however in opposite ways. | [3.0, 3.0, 2.0, 2.0, 1.0] | Medicine | train | 2.2 | tweets | 376419863214182400 |
10.1038/s41586-018-0347-0 | Medicine_tweet_289 | Quite excited to share our article on high-rate energy storage in niobium tungsten oxides in @username!! This has been a work in progress for roughly four years and involved seven different beamtimes @username and @username and PFG NMR! | Any Methods, including any statements of data availability and Nature Research reporting summaries, along with any additional references and Source Data files, are available in the online version of the paper at https://doi.org/10.1038/s416-018-0347-0. | Quite excited to share our article on high-rate energy storage in niobium tungsten oxides in @username!! This has been a work in progress for roughly four years and involved seven different beamtimes @username and @username and PFG NMR! | These criteria, which lead to extremely high power and energy densities (Fig. Any Methods, including any statements of data availability and Nature Research reporting summaries, along with any additional references and Source Data files, are available in the online version of the paper at https://doi.org/10.1038/s416-018-0347-0. 1, Supplementary Fig. | [1.0, 2.0, 1.0, 3.0, 2.0] | Medicine | train | 1.8 | tweets | 1022171486340239360 |
10.1016/j.jtho.2016.01.011 | Medicine_tweet_29 | Metabolic phenotyping of plasma could be used to detect lung cancer in Belgian cohort. | In conclusion, this paper validates 1 H-NMR metabolic phenotyping of blood plasma as a complementary tool to discriminate between patients with lung cancer and controls. | Metabolic phenotyping of plasma could be used to detect lung cancer in Belgian cohort. | These findings indicate that lung cancer cells utilize at least some steps of the gluconeogenic pathway to adapt to low-glucose conditions as a result of insufficient blood flow. In conclusion, this paper validates 1 H-NMR metabolic phenotyping of blood plasma as a complementary tool to discriminate between patients with lung cancer and controls. Our findings indicate that metabolic alterations can already be detected in an early stage. | [5.0, 3.0, 3.0, 4.0, 5.0] | Medicine | train | 4 | tweets | 704624845577969664 |
10.1186/s13058-018-1049-0 | Medicine_tweet_290 | Congratulations to @username on latest #BreastCancer research publication. @username @username | This opens the way for testing new treatments that prevent metastasis by inducing/enforcing dormancy, and/or to eradicate MRD . | Congratulations to @username on latest #BreastCancer research publication. @username @username | Improved techniques to assess the MRD population and their dormant or reactivating state will be key to identifying the risk of future metastasis despite undergoing standard treatment. This opens the way for testing new treatments that prevent metastasis by inducing/enforcing dormancy, and/or to eradicate MRD . These drugs will be tested in a clinical trial of prostate cancer patients at risk of developing metastasis (Mount Sinai IRB no. | [1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | tweets | 1052288596449914885 |
10.1038/s41467-018-06824-8 | Medicine_tweet_291 | NEW PAPER from fantastic postdoc Sarah Kocher (@username) now PI at @username on the genetic basis of social behavior in halictid bees (w great collabs: @username, Pierce, Yu, Rubin): | We estimated the nucleotide diversity per site (π) to be 0.002, and we did not find differences in genetic diversity among social forms (Supplementary Table 1 ; two-sample t-test; t 4 = −0.961, p = 0.391). | NEW PAPER from fantastic postdoc Sarah Kocher (@username) now PI at @username on the genetic basis of social behavior in halictid bees (w great collabs: @username, Pierce, Yu, Rubin): | Whole-genome resequencing data identified a total of 2,6,960 genetic variants among 143 individuals of L. albipes that passed our quality filters (see Methods; Supplementary Data 1). We estimated the nucleotide diversity per site (π) to be 0.002, and we did not find differences in genetic diversity among social forms (Supplementary Table 1 ; two-sample t-test; t 4 = −0.961, p = 0.391). As in honey bees , LD decays rapidly with physical distance: | [1.0, 1.0, 3.0, 1.0, 3.0] | Medicine | train | 1.8 | tweets | 1052896612274589696 |
10.1001/jamainternmed.2016.0157 | Medicine_tweet_292 | Great talk on validation of a blood pressure app for your smartphone: Conclusion: Recall the App. #epilifestyle16 | IBP systolic BP readings were within , 10, and 1 mm Hg of the standard BP measurement 24%, 44%, and 9% of the time, respectively, whereas respective proportions for diastolic BP were 26%, 48%, and 70%, correlating with the lowest possible accuracy grade in all categories by British Hypertensive Society scoring. | Great talk on validation of a blood pressure app for your smartphone: Conclusion: Recall the App. #epilifestyle16 | IBP underestimated higher BPs and overestimated lower BPs (Figure) . IBP systolic BP readings were within , 10, and 1 mm Hg of the standard BP measurement 24%, 44%, and 9% of the time, respectively, whereas respective proportions for diastolic BP were 26%, 48%, and 70%, correlating with the lowest possible accuracy grade in all categories by British Hypertensive Society scoring. Spearman ρ was 0.44 (P < .001) for systolic BP and 0.41 (P < .001) for diastolic BP. | [3.0, 1.0, 2.0, 5.0] | Medicine | train | 3 | tweets | 705098247971303424 |
10.1038/nature22346 | Medicine_tweet_294 | A Challenge to Lepton Universality in B Meson Decays. | A confirmation of these results would point to new particles or interactions, and could have profound implications for our understanding of particle physics. | A Challenge to Lepton Universality in B Meson Decays. | For purely leptonic B − decays, the standard model prediction of the total decay rate Γ, which depends critically on the lepton mass squared m ℓ 2 , is: One of the key assumptions of the standard model of particle physics is that the interactions of the charged leptons, namely electrons, muons and taus, differ only because of their different masses. A confirmation of these results would point to new particles or interactions, and could have profound implications for our understanding of particle physics. SM 0 05 0 10 4 Decays to the lower-mass charged leptons, e − and μ − , are strongly suppressed by spin effects and have not yet been observed. | [1.0, 1.0, 1.0, 1.0, 3.0] | Medicine | train | 1.4 | tweets | 838940737831985154 |
10.1093/asj/sjw089 | Medicine_tweet_295 | New in @username by @username, a free read: #hairloss #hairtransplant #hair #oa | This 49-year-old man is a poor candidate for leg hair extraction because of complete hair loss in most areas. | New in @username by @username, a free read: #hairloss #hairtransplant #hair #oa | The author has observed that following scoring by the UPunch Rotor, a variable percentage of grafts is completely Figure 3 . This 49-year-old man is a poor candidate for leg hair extraction because of complete hair loss in most areas. In the areas with hair, the hair is also vellous-looking with densities below 8 per cm 2 . | [3.0, 2.0, 2.0, 2.0] | Medicine | train | 2.25 | tweets | 737437256739377152 |
10.1016/j.physbeh.2009.12.026 | Medicine_tweet_296 | Hunger & Thirst: Issues in Measurement & #Prediction of Eating & Drinking | This agrees with work in both animal models and humans ] that show about 70-75% of drinking occurs peri-prandially. | Hunger & Thirst: Issues in Measurement & #Prediction of Eating & Drinking | Otherwise, the peaks are highly synchronous. This agrees with work in both animal models and humans ] that show about 70-75% of drinking occurs peri-prandially. The weekday versus weekend differences in ingestive episodes highlight the importance of lifestyle and social custom on this activity . | [2.0, 3.0, 1.0, 2.0] | Medicine | train | 2 | tweets | 170241073459892224 |
10.1001/jamacardio.2018.1511 | Medicine_tweet_297 | 17 years after publishing NRMI data on race based differences in statin use, not much has changed. Yet, this study provides new insights into why. Perceptions of CV Risk and Statin Drugs and Racial Differences in Statin Use @username @username | Demographic, clinical, socioeconomic, belief-related, and clinician differences contributed to observed differences and represent potential targets for intervention. | 17 years after publishing NRMI data on race based differences in statin use, not much has changed. Yet, this study provides new insights into why. Perceptions of CV Risk and Statin Drugs and Racial Differences in Statin Use @username @username | CONCLUSIONS AND RELEVANCE African American individuals were less likely to receive guideline-recommended statin therapy. Demographic, clinical, socioeconomic, belief-related, and clinician differences contributed to observed differences and represent potential targets for intervention. Part of the explanation for this increased risk may be undertreatment of African American peoples for primary prevention. | [1.0, 4.0, 1.0, 3.0, 4.0] | Medicine | train | 2 | tweets | 1006928867200663555 |
10.1186/1472-6920-12-82 | Medicine_tweet_298 | Gender Differences in Medical Students' Motives & Career Choice | However, the significance of gender influence, stating the higher aspirations of women for general practice is not very strong (see table 4, Model 1: p = 0.046). | Gender Differences in Medical Students' Motives & Career Choice | The finding that men aspire more to surgery specialties and women prefer more often general practice and nonsurgery specialties is consistent with previous research . However, the significance of gender influence, stating the higher aspirations of women for general practice is not very strong (see table 4, Model 1: p = 0.046). In separate analyses of different stages of education this gender influence even disappeared. | [4.0, 3.0, 3.0, 4.0, 4.0] | Medicine | train | 3.6 | tweets | 241974413065584640 |
10.1016/j.neuron.2017.09.032 | Medicine_tweet_299 | Brain synchrony in implicit vs explicit learning #neuroscience
| In Figure 7A , we found that theta synchrony dropped both early (LM1, b = À0.28891, p = 0.027735, two-sided t test) and late (LM1, b = À0.27005, p = 0.015615). | Brain synchrony in implicit vs explicit learning #neuroscience
| This was the case. In Figure 7A , we found that theta synchrony dropped both early (LM1, b = À0.28891, p = 0.027735, two-sided t test) and late (LM1, b = À0.27005, p = 0.015615). In other words, we did not see any difference in the change in theta synchrony before and after learning, like we did for alpha-2/beta-1. | [3.0, 1.0, 2.0, 4.0] | Medicine | train | 2.5 | tweets | 918367395265351680 |
10.1377/hlthaff.2018.05101 | Medicine_tweet_32 | New @username study suggests that state efforts to remove barriers to using #telehealth might not be sufficient for increasing use, and new incentives for providers and consumers to adopt and use telehealth may be needed. @username | Policies that incentivize providers and health systems to use telehealth could be an important way to increase access to care for underserved populations. | New @username study suggests that state efforts to remove barriers to using #telehealth might not be sufficient for increasing use, and new incentives for providers and consumers to adopt and use telehealth may be needed. @username | Making telehealth easy to use is important but might not be enough to make providers or health systems invest the time, energy, and money needed to begin offering the service or expand its use. Policies that incentivize providers and health systems to use telehealth could be an important way to increase access to care for underserved populations. For example, offering financial incentives for providers to adopt telehealth may lead to increased usage, as payment incentives led to the increased adoption and use of electronic health records and patient-centered medical home status in safety-net clinics. | [1.0, 3.0, 5.0] | Medicine | train | 5 | tweets | 1069710580695609344 |
10.1001/jamapsychiatry.2015.0500 | Medicine_tweet_33 | Antipsychotic use increased from 2006 to 2010 for adolescents and young adults in the US #percentagesthough... | There were approximately 270 000 antipsychotic prescriptions dispensed to younger children, 2.14 million to older children, 2.80 million to adolescents, and 1.83 million to young adults nationwide in 2010. | Antipsychotic use increased from 2006 to 2010 for adolescents and young adults in the US #percentagesthough... | The age and sex composition of the IMS population that filled at least 1 prescription of any kind closely resembled the composition of the corresponding population from the nationally representative Medical Expenditure Panel Survey. There were approximately 270 000 antipsychotic prescriptions dispensed to younger children, 2.14 million to older children, 2.80 million to adolescents, and 1.83 million to young adults nationwide in 2010. Across the 4 age groups, almost all of the antipsychotic prescriptions (96.7%) were for secondgeneration medications. | [3.0, 4.0, 2.0, 4.0] | Medicine | train | 3.25 | tweets | 616296471634255872 |
10.1186/s12887-019-1528-1 | Medicine_tweet_35 | Academic performance, executive function scores are positively correlated w/ age, Vitamin E levels, total antioxidant capacity, physical activity, negatively correlated w/ BMI (open access)
#nutrition #cardio #hiit #exercise #fitness #fit #muscle #lift | The academic performance and executive function scores were found to be positively correlated with age, gender, α-and γ-tocopherol, TAC activity, and PA score; and negatively correlated with BMI. | Academic performance, executive function scores are positively correlated w/ age, Vitamin E levels, total antioxidant capacity, physical activity, negatively correlated w/ BMI (open access)
#nutrition #cardio #hiit #exercise #fitness #fit #muscle #lift | Groups of adolescents who were moderately of highly active were found to have significantly higher levels of vitamin E, TAC activity, LTPA, and academic performance compared with mildly active participants. The academic performance and executive function scores were found to be positively correlated with age, gender, α-and γ-tocopherol, TAC activity, and PA score; and negatively correlated with BMI. Vitamin E levels and TAC activity could be used as indicators for improving executive function, PA and academic performance among students. | [5.0, 5.0, 3.0, 4.0] | Medicine | train | 4.25 | tweets | 1130400928534806528 |
10.1001/jama.2014.15690 | Medicine_tweet_36 | Low-dose #aspirin and #CV events in #Japanese pts 60 yrs or older w atherosclerotic risk factors #AHA14 | Once-daily, low-dose aspirin did not significantly reduce the risk of the composite outcome of cardiovascular death, nonfatal stroke, and nonfatal myocardial infarction among Japanese patients 60 years or older with atherosclerotic risk factors. | Low-dose #aspirin and #CV events in #Japanese pts 60 yrs or older w atherosclerotic risk factors #AHA14 | Reduction in the incidence of colorectal cancer may influence the overall benefit-risk profile of aspirin. Further analyses of the JPPP study data are planned, including analysis of deaths associated with cancers, to allow more precise identification of the patients for whom aspirin treatment may be most beneficial. Once-daily, low-dose aspirin did not significantly reduce the risk of the composite outcome of cardiovascular death, nonfatal stroke, and nonfatal myocardial infarction among Japanese patients 60 years or older with atherosclerotic risk factors. | [2.0, 4.0, 4.0, 3.0, 4.0] | Medicine | train | 3.4 | tweets | 534390530533515264 |
10.1136/bmj.j5644 | Medicine_tweet_37 | A healthy diet seems to most benefit people with a genetic predisposition to #obesity
@username #OA | Moreover, the beneficial effect of improved diet quality on weight management was particularly pronounced in people at high genetic risk for obesity. | A healthy diet seems to most benefit people with a genetic predisposition to #obesity
@username #OA | These data indicate that improving adherence to healthy dietary patterns could attenuate the genetic association with weight gain. Moreover, the beneficial effect of improved diet quality on weight management was particularly pronounced in people at high genetic risk for obesity. Weights reported in questionnaires and measured by technicians were highly correlated (r=0.97 in both studies) in a validation subsample. | [4.0, 4.0, 5.0, 5.0, 5.0] | Medicine | train | 4.6 | tweets | 951260235104047104 |
10.1098/rsos.172398 | Medicine_tweet_38 | The #behaviour of overweight #dogs shows similarity with #personality traits of overweight humans [BIOLOGY (WHOLE ORGANISM)] BLet @username | These results are very similar to those expected from the parallel models that exist between certain personality traits and being overweight in humans, suggesting that dogs are indeed a promising model for experimentally investigating obesity in humans. | The #behaviour of overweight #dogs shows similarity with #personality traits of overweight humans [BIOLOGY (WHOLE ORGANISM)] BLet @username | Our results also confirm that overweight dogs, as opposed to normal weight dogs, tried to maximize food intake from the higher quality food and hesitated to do the task when the food reward was uncertain. These results are very similar to those expected from the parallel models that exist between certain personality traits and being overweight in humans, suggesting that dogs are indeed a promising model for experimentally investigating obesity in humans. Dogs, due to their shared living environment with humans, may provide a beneficial model to study the causes and consequences of obesity. | [5.0, 4.0, 5.0, 5.0, 5.0] | Medicine | train | 4.8 | tweets | 1004296558983036928 |
10.1001/jama.2015.1693 | Medicine_tweet_39 | Balloon-Expandable Stent vs Medical Therapy for Intracranial Stenosis | These findings do not support the use of a balloon-expandable stent for patients with symptomatic intracranial arterial stenosis. | Balloon-Expandable Stent vs Medical Therapy for Intracranial Stenosis | Worsening of baseline disability score (modified Rankin Scale) occurred in more patients in the stent group (14/58; 24.1% [95% CI, 13.9%-37.2%]) vs the medical group (6/53; 11.3% [95% CI,.0%]) (P = .09).The EuroQol-5D showed no difference in any of the 5 dimensions between groups at 12-month follow-up. These findings do not support the use of a balloon-expandable stent for patients with symptomatic intracranial arterial stenosis. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00816166. | [3.0, 3.0, 1.0, 2.0, 2.0] | Medicine | train | 2.2 | tweets | 580401347905871872 |
10.1007/s40264-014-0155-x | Medicine_tweet_4 | Patients reporting AEs on TW showed sophistication - role in pharmacovigilance not established: #hcsm #pharmacy | Conclusion Patients reporting AEs on Twitter showed a range of sophistication when describing their experience. | Patients reporting AEs on TW showed sophistication - role in pharmacovigilance not established: #hcsm #pharmacy | Similar overall distribution profiles were observed, with Spearman rank correlation rho of 0.75 (p \ 0.0001) between Proto-AEs reported in Twitter and FAERS by SOC. Conclusion Patients reporting AEs on Twitter showed a range of sophistication when describing their experience. Additional work is needed to improve data acquisition and automation. | [5.0, 3.0, 2.0, 3.0] | Medicine | train | 3.25 | tweets | 461596772389756929 |
10.1001/jamasurg.2018.0672 | Medicine_tweet_40 | Poorer postoperative recovery in patients with lower functional health literacy! | Health literacy is a relevant factor to consider for optimizing the postoperative recovery in patients undergoing day surgery. | Poorer postoperative recovery in patients with lower functional health literacy! | CONCLUSIONS AND RELEVANCE Inadequate FHL in patients undergoing day surgery was associated with poorer postoperative recovery and a lower health-related quality of life. Health literacy is a relevant factor to consider for optimizing the postoperative recovery in patients undergoing day surgery. 6 Considering this, the association between FHL and postoperative recovery in patients undergoing day surgery needs to be assessed. | [4.0, 3.0, 4.0, 4.0, 4.0] | Medicine | train | 3.8 | tweets | 989287935248912384 |
10.1016/j.jpain.2017.11.005 | Medicine_tweet_41 | #acupuncture has a clinically relevant effect on #chronicpain that persists over time.
The effect of acupuncture cannot be explained only by placebo effects. | Another novel finding is the higher than average effects of acupuncture on upper body musculoskeletal pain. | #acupuncture has a clinically relevant effect on #chronicpain that persists over time.
The effect of acupuncture cannot be explained only by placebo effects. | In some cases, heterogeneity was also driven by a set of outlying trials with large effect sizes. Another novel finding is the higher than average effects of acupuncture on upper body musculoskeletal pain. We now have sufficient data to conduct a meta-analysis for neck pain and for shoulder pain, even after exclusion of outlying trials. | [4.0, 2.0, 3.0, 4.0] | Medicine | train | 3.25 | tweets | 990283938320076801 |
10.1016/j.psyneuen.2016.08.027 | Medicine_tweet_42 | Can women's cortisol levels predict their likelihood of getting #pregnant when having #IVF? | Despite these potential limitations, the present study extends the available evidence for the role of cortisol on clinical pregnancy in IVF patients and provides the first evidence that elevated chronic cortisol levels are associated with a reduced likelihood of pregnancy. | Can women's cortisol levels predict their likelihood of getting #pregnant when having #IVF? | It is also not clear how generalizable our results are to women trying to conceive naturally; also our findings extend only to clinical pregnancy. Despite these potential limitations, the present study extends the available evidence for the role of cortisol on clinical pregnancy in IVF patients and provides the first evidence that elevated chronic cortisol levels are associated with a reduced likelihood of pregnancy. Thus, further research is needed to not only corroborate these findings but also identify the pathways. | [4.0, 5.0, 3.0, 4.0] | Medicine | train | 4 | tweets | 803233989997699072 |
10.1038/s41467-019-09961-w | Medicine_tweet_43 | Thrilled that our new paper is out @username: In this work with Dan Schacter and @username, we show that episodic simulations can form real-life attitudes and how this is supported by affective representations in the vmPFC. 1/5 | By this process, episodic simulations modify attitudes toward the very elements that the simulations had been based on, thus influencing how we evaluate our real-life environment. | Thrilled that our new paper is out @username: In this work with Dan Schacter and @username, we show that episodic simulations can form real-life attitudes and how this is supported by affective representations in the vmPFC. 1/5 | Such evaluative conditioning forms attitudes by changing the liking of the CS to align with the valence of the UCS . By this process, episodic simulations modify attitudes toward the very elements that the simulations had been based on, thus influencing how we evaluate our real-life environment. Our hypothesis assigns a key role to the vmPFC in mediating such presumed attitude change. | [4.0, 5.0, 4.0, 5.0, 5.0] | Medicine | train | 4.6 | tweets | 1129381200391540737 |
10.1186/s12940-019-0488-0 | Medicine_tweet_44 | There are 72, 17, and 11 pesticides approved for outdoor agricultural applications in the USA that are banned or in the process of complete phase out in the EU, Brazil, and China, respectively. | More than 10% of total pesticide use in the USA in 2016 was from pesticide ingredients either banned, not approved or of unknown status in all three agricultural nations (Table 1 and Additional file 5: Table S137 ). | There are 72, 17, and 11 pesticides approved for outdoor agricultural applications in the USA that are banned or in the process of complete phase out in the EU, Brazil, and China, respectively. | Of the 1.2 billion pounds of pesticides used in USA agriculture in 2016, roughly 322 million pounds were of pesticides banned in the EU, 40 million were of pesticides banned in China and nearly 26 million were of pesticides banned in Brazil (Table 1 and Additional file 5: Tables S131-S133 ). More than 10% of total pesticide use in the USA in 2016 was from pesticide ingredients either banned, not approved or of unknown status in all three agricultural nations (Table 1 and Additional file 5: Table S137 ). From 1992 to 2016, the trends in use of the 13 pesticides that are banned in at least two other places and used in the USA varied by pesticide (Fig. | [3.0, 3.0, 4.0, 3.0, 4.0] | Medicine | train | 3.4 | tweets | 1136804388507463680 |
10.1038/s41598-018-29793-w | Medicine_tweet_45 | Nasal microbiota clusters associate with inflammatory response, viral load... - Lehtinen MJ et al. - #microbiome | Thus, microbiota at the time of infection may influence subsequent rhinovirus viral load. | Nasal microbiota clusters associate with inflammatory response, viral load... - Lehtinen MJ et al. - #microbiome | Subjects with Ps/Mix cluster had significantly lower viral load than those subjects with Mor or Staph predominant microbiota types (Fig. Thus, microbiota at the time of infection may influence subsequent rhinovirus viral load. The results also suggest that high inflammatory response does not lead to low viral load as the subjects with Ps/Mix and Mor clusters had both relatively high inflammatory cytokine response and only Ps/Mix cluster had low viral load. | [2.0, 3.0, 4.0, 4.0] | Medicine | train | 3.25 | tweets | 1024582940532133889 |
10.1038/srep01456 | Medicine_tweet_47 | Bed bugs evolved unique adaptive strategy to resist pyrethroid ...: Recent advances in genomic and post-genomi... | Our data showed that multiple mechanisms involved in pyrethroid resistance is not only a phenomenon occurring in laboratory bed bug strains but also is widespread in naturally occurring bed bug populations (Figs. | Bed bugs evolved unique adaptive strategy to resist pyrethroid ...: Recent advances in genomic and post-genomi... | 3D) is also interesting and further research is required to understand functional significance of this observation. Our data showed that multiple mechanisms involved in pyrethroid resistance is not only a phenomenon occurring in laboratory bed bug strains but also is widespread in naturally occurring bed bug populations (Figs. Inactivation of four P450 target genes significantly enhanced the susceptibility of resistant bed bugs to pyrethroid insecticide, which further confirmed the involvement of P450-mediated metabolic detoxification in pyrethroid resistance of bed bugs. | [3.0, 5.0, 3.0, 5.0] | Medicine | train | 4 | tweets | 312697337266991106 |
10.1001/jama.2018.20578 | Medicine_tweet_48 | In this case, I'm not really sure that pooling 164 225 heterogenous patients really does help... I'm not convinced. #aspirin for primary prevention is still dead to me. @username @username | In this meta-analysis of 13 trials enrolling 164 225 participants without cardiovascular disease, aspirin use was associated with reductions in the composite cardiovascular outcome consisting of cardiovascular mortality, nonfatal myocardial infarction, and nonfatal stroke. | In this case, I'm not really sure that pooling 164 225 heterogenous patients really does help... I'm not convinced. #aspirin for primary prevention is still dead to me. @username @username | Aspirin use was associated with increased risk of major bleeding (HR, In this meta-analysis of 13 trials enrolling 164 225 participants without cardiovascular disease, aspirin use was associated with reductions in the composite cardiovascular outcome consisting of cardiovascular mortality, nonfatal myocardial infarction, and nonfatal stroke. However, aspirin use was associated with an increased risk of major bleeding, intracranial bleeding, and major gastrointestinal bleeding with comparable absolute risk estimates. | [3.0, 2.0, 3.0, 1.0, 3.0] | Medicine | train | 2.4 | tweets | 1087857553655005185 |
10.1073/pnas.1504869112 | Medicine_tweet_49 | Lianas reduce tropical forests' #carbon accumulation and storage #TheTarzanEffect | This study is the first direct demonstration of liana effects at the ecosystem scale and illustrates the important role of lianas in tropical forests, particularly with respect to carbon budgets. | Lianas reduce tropical forests' #carbon accumulation and storage #TheTarzanEffect | By impacting on tree growth and survival, lianas impact the carbon balance of these forests. This study is the first direct demonstration of liana effects at the ecosystem scale and illustrates the important role of lianas in tropical forests, particularly with respect to carbon budgets. Lianas are increasing in biomass and productivity throughout the tropics, and thus our findings have even greater relevance in terms of the fate of the tropical carbon balance, as well as for global atmospheric CO 2 levels, in a changing climate. | [4.0, 5.0, 2.0, 4.0, 4.0] | Medicine | train | 3.8 | tweets | 658602471737069568 |
10.1038/s41598-018-29793-w | Medicine_tweet_5 | Characterizing the healthy nasal #microbiome discovers groups of microbes that differently modulate the inflammatory response and relate differently to symptom severity in rhinoviral colds. #commoncold #immuneresponse
| The microbiota clusters appear to associate with different inflammatory response, viral titer, and symptom severity profiles in rhinovirus infection. | Characterizing the healthy nasal #microbiome discovers groups of microbes that differently modulate the inflammatory response and relate differently to symptom severity in rhinoviral colds. #commoncold #immuneresponse
| We found that nasal microbiotas of healthy adults in our study cohort grouped into six distinct clusters Staph, Cor/All, Mor, Hae, Ps/Mix, and Mixed, based on the predominant bacterial genera in the nasal microflora. The microbiota clusters appear to associate with different inflammatory response, viral titer, and symptom severity profiles in rhinovirus infection. Our study is aligned with the previous findings suggesting that the microbiota in the nose has seasonal variation. | [5.0, 5.0, 3.0, 3.0] | Medicine | train | 4 | tweets | 1093938835413553152 |
10.1073/pnas.1504869112 | Medicine_tweet_50 | Lianas reduce net carbon storage in #tropicalforests by 75%! Lianas on the rise, implications for the land C sink | Notwithstanding, our results indicate that, due to their unique attributes, lianas have the potential to severely reduce both the carbon sink potential and long-term carbon storage capacity of tropical forests. | Lianas reduce net carbon storage in #tropicalforests by 75%! Lianas on the rise, implications for the land C sink | Longer-term data are needed to assess whether this initial difference in carbon sink potential persists over time. Notwithstanding, our results indicate that, due to their unique attributes, lianas have the potential to severely reduce both the carbon sink potential and long-term carbon storage capacity of tropical forests. While the strength of the liana effect will vary with the density and biomass of lianas, the increase in liana density, biomass, and productivity reported in many neotropical forests (9, 10, 23) may be partially responsible for the longterm decline in the Amazonian carbon sink , which in turn contributes to increasing atmospheric carbon dioxide levels and accelerated climate change. | [4.0, 4.0, 4.0, 4.0] | Medicine | train | 4 | tweets | 657953352681172996 |
10.1126/sciadv.aau2477 | Medicine_tweet_51 | Our new JPL-NASA study out in Science Adv., uses GPS to track the weight of #HurricaneHarvey's stormwater. We found Houston was not only pushed down 2 cm by Harvey's stormwater, but then sprung back up over ~5 weeks, giving clues to water loss over time. | Inversion of these data shows that a third of Harvey's total stormwater was captured on land (25.7 ± .0 km ), indicating that the rest drained rapidly into the ocean at a rate of 8.2 km | Our new JPL-NASA study out in Science Adv., uses GPS to track the weight of #HurricaneHarvey's stormwater. We found Houston was not only pushed down 2 cm by Harvey's stormwater, but then sprung back up over ~5 weeks, giving clues to water loss over time. | Water left in Harvey's wake should cause elastic loading and subsidence of Earth's crust, and uplift as it drains into the ocean and evaporates. Inversion of these data shows that a third of Harvey's total stormwater was captured on land (25.7 ± .0 km ), indicating that the rest drained rapidly into the ocean at a rate of 8.2 km Over a period of 7 days, Harvey produced record-breaking rainfall, with 1.54 m of precipitation measured southeast of Houston, causing extensive flooding and $125 billion in damage, an amount second only to Hurricane Katrina . | [3.0, 3.0, 3.0, 2.0, 3.0] | Medicine | train | 2.8 | tweets | 1042474835681533952 |
10.1038/s41390-018-0199-1 | Medicine_tweet_52 | Neonatal regulatory behavior problems are predicted by maternal early pregnancy overweight & obesity
A number of 3117 women of the PREDO Study filled in a questionnaire on regulatory behavior problems at the child’s mean age of 16.9 days
| Our findings suggest that prevention of overweight/obesity in women of childbearing age will benefit the offspring by reducing the burden of regulatory problems in infancy and preventing their long-term neurodevelopmental consequences. | Neonatal regulatory behavior problems are predicted by maternal early pregnancy overweight & obesity
A number of 3117 women of the PREDO Study filled in a questionnaire on regulatory behavior problems at the child’s mean age of 16.9 days
| In sum, our study showed that infants of overweight/obese mothers displayed higher levels of regulatory behavior problems and were more likely to display problems on multiple areas of behavioral self-regulation. Regulatory behavior problems partially mediated the effects of maternal overweight/obesity on childhood developmental milestones. Our findings suggest that prevention of overweight/obesity in women of childbearing age will benefit the offspring by reducing the burden of regulatory problems in infancy and preventing their long-term neurodevelopmental consequences. | [4.0, 5.0, 4.0, 4.0, 4.0] | Medicine | train | 4.2 | tweets | 1053292082104881152 |
10.1177/0141076815593403 | Medicine_tweet_53 | stat. meth in Swedish trials has led to overestimat of risk reduction in breast cancer death due to mammo screening. | Our re-calculations of Swedish trial revealed that risks of breast cancer death were similar for cancers found during the intervention and the post-intervention periods, indicating that reductions in the risk of breast cancer death also applied to cancer cases diagnosed when screening (or absence of screening) was the same in both screening and control groups. | stat. meth in Swedish trials has led to overestimat of risk reduction in breast cancer death due to mammo screening. | The compensation argument invoked by Swedish trial investigators 6, is thus not tenable. Our re-calculations of Swedish trial revealed that risks of breast cancer death were similar for cancers found during the intervention and the post-intervention periods, indicating that reductions in the risk of breast cancer death also applied to cancer cases diagnosed when screening (or absence of screening) was the same in both screening and control groups. Such result is compatible with an effect of being allocated to the screening or to the control group on the risk of breast cancer death (allocation effect), but not with an effect of mammography screening (screening effect) on that risk. | [3.0, 3.0, 3.0, 5.0] | Medicine | train | 3.5 | tweets | 618657906418950144 |
10.1093/geronb/gbv101 | Medicine_tweet_54 | The secret of staying young
I personally thrive on stress. And if necessary will create situations that encourage it.
The Combined Effects of Daily Stressors and Major Life Events on Daily Subjective... | Taken together, we predict that when a significant relationship exists between daily stressors and subjective age, it will be mediated by positive affect, personal control, and negative affect. | The secret of staying young
I personally thrive on stress. And if necessary will create situations that encourage it.
The Combined Effects of Daily Stressors and Major Life Events on Daily Subjective... | We further suspect that on a daily level, individuals' subjective age may be influenced by negative affect. Taken together, we predict that when a significant relationship exists between daily stressors and subjective age, it will be mediated by positive affect, personal control, and negative affect. Nearly all participants reported their employment status as retired (n = 41). | [3.0, 3.0, 1.0] | Medicine | train | 2.333333 | tweets | 1014776707755270144 |
10.1001/jama.2013.277165 | Medicine_tweet_56 | #Anticoagulation With #Otamixaban and Ischemic Events in NSTE-ACS #esc2013 | Otamixaban did not reduce ischemic events compared with UFH plus eptifibatide but increased bleeding among patients with NSTE-ACS and a planned invasive strategy. | #Anticoagulation With #Otamixaban and Ischemic Events in NSTE-ACS #esc2013 | Other regimens might have offered a different benefit-risk profile, 19, 26, 27 but because otamixaban did not display superior efficacy and did show worse safety, this point is moot. Otamixaban did not reduce ischemic events compared with UFH plus eptifibatide but increased bleeding among patients with NSTE-ACS and a planned invasive strategy. These findings do not support the use of otamixaban for patients with NSTE-ACS undergoing planned early percutaneous coronary intervention. | [2.0, 3.0, 4.0, 3.0, 3.0] | Medicine | train | 3 | tweets | 374147717842206721 |
10.1038/s41598-018-25573-8 | Medicine_tweet_57 | A customised #cancertreatment replicating ovarian #tumours inside chicken eggs | These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer. | A customised #cancertreatment replicating ovarian #tumours inside chicken eggs | Lastly, a tumor could be established in the egg using tumor samples from ovarian cancer patients and that our nanoparticles were effective in eliminating the tumor. These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer. Tumor recurrence and metastasis are primarily responsible for the 70% five-year mortality of advanced EOC. | [1.0, 3.0, 3.0, 3.0] | Medicine | train | 2.5 | tweets | 1006702719170744321 |
10.1001/jama.2018.14619 | Medicine_tweet_59 | In our latest @username funded study in @username, people with severe obesity & diabetes who had bariatric surgery were associated with 40% lower 5-year risk of heart attack and stroke than matched people who got usual medical care | Health care professionals should engage patients with severe obesity and type 2 diabetes in a shared decision making conversation about the potential role of bariatric surgery in the prevention of macrovascular events. | In our latest @username funded study in @username, people with severe obesity & diabetes who had bariatric surgery were associated with 40% lower 5-year risk of heart attack and stroke than matched people who got usual medical care | The findings require confirmation in randomized clinical trials. Health care professionals should engage patients with severe obesity and type 2 diabetes in a shared decision making conversation about the potential role of bariatric surgery in the prevention of macrovascular events. [5] [6] [7] [8] [9] In comparison, patients who have bariatric surgery have better glycemic control and greater macrovascular risk factor reduction than those who get both intensive lifestyle and medical treatment combined. | [4.0, 5.0, 4.0, 3.0, 2.0] | Medicine | train | 3.6 | tweets | 1052217491076931584 |
10.1038/s41467-018-08278-4 | Medicine_tweet_6 | Ken Muneoka and colleagues @username find that BMP9 treatment promotes joint regeneration from digit amputation wounds.
| We show here that Bmp9 is transiently expressed during digit joint cavitation and that BMP9 treatment stimulates joint regeneration. | Ken Muneoka and colleagues @username find that BMP9 treatment promotes joint regeneration from digit amputation wounds.
| Unlike other BMP family members, BMP9 is not effected by BMP antagonists such as Noggin 12 which suppresses BMP signaling and is necessary for joint morphogenesis . We show here that Bmp9 is transiently expressed during digit joint cavitation and that BMP9 treatment stimulates joint regeneration. During angiogenesis, BMP9 acts in a contextdependent manner, inhibiting neovascularization in a model of age-related macular degeneration , while stimulating angiogenesis associated with induced osteogenesis . | [4.0, 5.0, 1.0, 4.0, 5.0] | Medicine | train | 5 | tweets | 1095638718826926080 |
10.1111/jgs.15671 | Medicine_tweet_60 | Quality of end of life care in U.S. hospitals is poor. Improving nurse work environments may be a key intervention to improve EOL care quality.
@username @username | The best predictor of poor quality was the nurse practice environment. | Quality of end of life care in U.S. hospitals is poor. Improving nurse work environments may be a key intervention to improve EOL care quality.
@username @username | The best predictor of poor quality was the nurse practice environment. Nurses in the best environments were 55% less likely than nurses in poor environments to rate their hospital's overall end-oflife care quality unfavorably (odds ratio = 0.45; 95% confidence interval = 0.39-0.52; P < .001). CONCLUSION: Quality of end-of-life care in US hospitals is imperfect and is significantly worse in hospitals with poor nurse practice environments than in hospitals with the best environments. | [5.0, 4.0, 4.0, 4.0, 1.0] | Medicine | train | 5 | tweets | 1069599220720697349 |
10.1016/j.ejca.2017.11.022 | Medicine_tweet_61 | Consumption of #processed #meat may increase risk of #breast #cancer | Among participants who had the highest intake of processed meat, the incidence of breast cancer was 2.55 per 1,000 population per annum among those with low cooked vegetable intake and 2.35 per 1,000 per annum among those with high intake. | Consumption of #processed #meat may increase risk of #breast #cancer | This was due to the absolute risk already being higher in this sub-group; among participants who ate no processed meat, the incidence of breast cancer was 2.46 per 1,000 population per annum among those with low intake of cooked vegetables compared with only 2.01 per 1,000 per annum among those with high vegetable intake. Among participants who had the highest intake of processed meat, the incidence of breast cancer was 2.55 per 1,000 population per annum among those with low cooked vegetable intake and 2.35 per 1,000 per annum among those with high intake. There was no significant interaction with menopausal status. | [4.0, 4.0, 3.0, 4.0] | Medicine | train | 3.75 | tweets | 945569755339124737 |
10.1080/00224499.2013.843148 | Medicine_tweet_62 | Of 600 12-15yo, 54% hadn't discussed any sexual health issues w/ dating partners, 29% w/ parents, 25% w/ best friends | Among this sexually active sample, 20 adolescents (38%) reported they had not used condoms every time they had sex in the past year, and 9 youth (17%) reported they had not discussed any sexual health topics with their dating partners. | Of 600 12-15yo, 54% hadn't discussed any sexual health issues w/ dating partners, 29% w/ parents, 25% w/ best friends | Of the 603 7th and 8th graders that we sampled, 53 (8.8%; 29 girls, 24 boys) had engaged in sexual intercourse in the past year and 23 (3.8%; 12 girls, 11 boys) had had sex with two or more partners. Among this sexually active sample, 20 adolescents (38%) reported they had not used condoms every time they had sex in the past year, and 9 youth (17%) reported they had not discussed any sexual health topics with their dating partners. In addition, when asked about use of protection at first intercourse, 29 youth (55%) reported they had used a condom, and 8 of these adolescents (15%) indicated they had used both condoms and birth control pills the first time they had sex. | [3.0, 4.0, 3.0, 3.0, 4.0] | Medicine | train | 3.4 | tweets | 487250531019423744 |
10.1186/s12889-017-4672-2 | Medicine_tweet_63 | Using your mobile phone during #pregnancy is unlikely to cause adverse neurodevelopmental effects #bmcpublichealth | Our unique findings do not support the hypothesis of adverse effects on children's language, communication and motor skills due to maternal cell phone use during gestation. | Using your mobile phone during #pregnancy is unlikely to cause adverse neurodevelopmental effects #bmcpublichealth | These associations were confirmed by dose-response trends, even after excluding non-users. Our unique findings do not support the hypothesis of adverse effects on children's language, communication and motor skills due to maternal cell phone use during gestation. Nevertheless, in the Spanish study cell phone users had children who scored higher in the Bayley mental scale and in the Danish study there was a trend for lower risk for cognitive/language delay at 6 months [ . | [5.0, 5.0, 5.0, 5.0, 5.0] | Medicine | train | 5 | tweets | 904972366790479876 |
10.1001/jamainternmed.2013.6536 | Medicine_tweet_64 | MT @username: Replacing carbs & animal fat with veg fat linked to lower risk of lethal prostate cancer. JAMA | In this prospective analysis, vegetable fat intake after diagnosis was associated with a lower risk of lethal prostate cancer and all-cause mortality. | MT @username: Replacing carbs & animal fat with veg fat linked to lower risk of lethal prostate cancer. JAMA | Post-diagnostic intakes of mayonnaise and margarine were not associated with risk of lethal prostate cancer or all-cause mortality. In this prospective analysis, vegetable fat intake after diagnosis was associated with a lower risk of lethal prostate cancer and all-cause mortality. Among 525 Swedish men, marine fatty acids were associated with lower risk of prostate cancer death (events: 222; HR Q4 v. Q1: 0.5; 5% CI: 0.40, 0.87) and, among the men diagnosed with localized disease (46 events), myristic acid and shortchain saturated fatty acids were associated with higher risk of prostate cancer death (HR Q4 v Q1: 2.3; 5% CI: 1.06, 5.38 and HR Q4 v. Q1: 2.88; 5% CI: 1.24, 6.67, respectively). | [5.0, 3.0, 5.0, 5.0] | Medicine | train | 4.5 | tweets | 344467954030739456 |
10.1016/j.bodyim.2016.09.005 | Medicine_tweet_65 | Do you think Barbie has an effect on our body image?
In this recent study, the impact of different types of... | Continued exposure to Barbie in early childhood may lead girls to not only adopt a thin ideal but also, in combination with a variety of other thin-ideal transmitters, may prime them to more readily accept future thin-ideal promoting messages. | Do you think Barbie has an effect on our body image?
In this recent study, the impact of different types of... | However, it is still possible that different types of exposure could have differential cumulative impact over time, which would only become apparent in a longitudinal study. Continued exposure to Barbie in early childhood may lead girls to not only adopt a thin ideal but also, in combination with a variety of other thin-ideal transmitters, may prime them to more readily accept future thin-ideal promoting messages. Future research is necessary to establish this link. | [3.0, 3.0, 4.0, 4.0] | Medicine | train | 3.5 | tweets | 788087593191677952 |
10.1377/hlthaff.2018.05101 | Medicine_tweet_66 | Excited to have our new @username study out in @username showing use of video visits for #telehealth has increased dramatically in the U.S. (from 6.6% in 2013 to 21.6% in 2016); however, use lowest for Medicaid, low income and rural populations. | The use of telehealth increased dramatically in the period 2013-16 across all population groups. | Excited to have our new @username study out in @username showing use of video visits for #telehealth has increased dramatically in the U.S. (from 6.6% in 2013 to 21.6% in 2016); however, use lowest for Medicaid, low income and rural populations. | [31] Demonstrating the role that telehealth can play in achieving the Triple Aim of improving quality and health outcomes while lowering the cost of care could prove to be a powerful incentive for increased uptake. The use of telehealth increased dramatically in the period 2013-16 across all population groups. While we found evidence that populations with limited mobility (such as Medicare beneficiaries younger than age sixty-five and people with selfreported physical or mental health concerns that limit their activities) were among the highest users, key underserved populations (including Medicaid, low-income, and rural populations) had significantly lower use of telehealth. | [4.0, 5.0, 1.0, 4.0, 5.0] | Medicine | train | 5 | tweets | 1069708111756193792 |
10.1001/jamaneurol.2017.4618 | Medicine_tweet_67 | Acute Brain Lesions Associated With DNS in Carbon Monoxide Poisoning | Diffusion-weighted imaging during the acute phase of carbon monoxide poisoning may therefore help identify patients at risk of developing these debilitating sequelae. | Acute Brain Lesions Associated With DNS in Carbon Monoxide Poisoning | The presence of acute brain lesions was significantly associated with the development of delayed neurological sequelae. Diffusion-weighted imaging during the acute phase of carbon monoxide poisoning may therefore help identify patients at risk of developing these debilitating sequelae. Documenting acute lesions that can potentially indicate the subsequent development of DNS could give clinicians and researchers useful information for understanding the pathophysiology of DNS and targeting prevention. | [4.0, 2.0, 3.0, 4.0, 4.0] | Medicine | train | 3.4 | tweets | 958173693795971073 |
10.1001/jamapediatrics.2018.0302 | Medicine_tweet_68 | #Vitamin D supplementation during #pregnancy may reduce the risk for underweight babies and fetal or infant mortality. | Late vitamin D supplementation (initiation at ≥20 weeks' gestation) improved birth weight, but early supplementation (initiation at <20 weeks' gestation) did not. | #Vitamin D supplementation during #pregnancy may reduce the risk for underweight babies and fetal or infant mortality. | We found that maternal vitamin D supplementation timing, dose, and administration method did not affect cord blood vitamin D concentration. Late vitamin D supplementation (initiation at ≥20 weeks' gestation) improved birth weight, but early supplementation (initiation at <20 weeks' gestation) did not. Most importantly, we found that the lower dose of vitamin D supplementation (≤2000 IU/d) reduced the risk of fetal or neonatal mortality and SGA, but the higher dose (>2000 IU/d) did not. | [4.0, 2.0, 5.0, 2.0] | Medicine | train | 4 | tweets | 1001559206733012993 |
10.1186/gb-2013-14-7-r73 | Medicine_tweet_70 | vlincRNA (50kb - 700kb long) in pluripotency and cancer - Genome Biol h/t @username | Our results suggest that gene regulation via vlincRNAs and macroRNAs could be a general theme in human cells. | vlincRNA (50kb - 700kb long) in pluripotency and cancer - Genome Biol h/t @username | These properties make vlincRNA regions similar to macroRNAs which were previously associated only with the regulation of imprinting . Our results suggest that gene regulation via vlincRNAs and macroRNAs could be a general theme in human cells. In this respect, the abundance of these transcripts relative to annotated coding mRNAs is noteworthy. | [2.0, 4.0, 1.0, 3.0, 3.0] | Medicine | train | 2.6 | tweets | 365501527806316546 |
10.1007/s00125-015-3781-7 | Medicine_tweet_71 | Major fall in diabetes-related amputations since the 1990s #Diabetologia @username @username | The total number of amputations amounted to 2,832, of which 1,285 were among individuals with diabetes and 1,547 among individuals without diabetes. | Major fall in diabetes-related amputations since the 1990s #Diabetologia @username @username | The different curves thus start at age of diagnosis and duration of diabetes equal to 0, so it can be seen that the initial high rates decrease in about 1 year and the major effect is then age related. The total number of amputations amounted to 2,832, of which 1,285 were among individuals with diabetes and 1,547 among individuals without diabetes. We found a substantial reduction by calendar time in BAA rates among patients with diabetes of almost 10% per year. | [3.0, 2.0, 3.0, 3.0] | Medicine | train | 2.75 | tweets | 668700522493313024 |
10.1002/ijc.31746 | Medicine_tweet_73 | Today's #MastermindFind: Sequencing and analysis of ANO7 reveals Caucasian SNPs associated with increased risk of prostate cancer, or decreased patient survival. #ProstateCancer #genetics
| In our study, higher ANO7 mRNA expression strongly correlated with poor overall survival in PrCa patients. | Today's #MastermindFind: Sequencing and analysis of ANO7 reveals Caucasian SNPs associated with increased risk of prostate cancer, or decreased patient survival. #ProstateCancer #genetics
| on the other hand, reported high individual variability of ANO expression between individual samples, both in terms of absolute expression levels and of expression level ratios between matched normal and tumorous prostate. In our study, higher ANO7 mRNA expression strongly correlated with poor overall survival in PrCa patients. Multivariate analysis compared high and low ANO7 expression and showed an even stronger negative survival effect than the model with the three selected SNPs, indicating that there might be additional variants that regulate expression. | [4.0, 4.0, 5.0, 5.0, 4.0] | Medicine | train | 4.4 | tweets | 1044200031992139776 |
10.1001/jamapediatrics.2013.78 | Medicine_tweet_74 | Parent conversations with children about their weight associated with disordered eating behaviours | This study builds on recent research focusing on fathers and their role in adolescent eating disorders treatment 32, [41] [42] [43] and finds that adolescents whose fathers engaged in weight conversations were significantly more likely to engage in dieting and UWCBs than adolescents whose fathers did not. | Parent conversations with children about their weight associated with disordered eating behaviours | This approach may be particularly important for parents of overweight or obese adolescents. This study builds on recent research focusing on fathers and their role in adolescent eating disorders treatment 32, [41] [42] [43] and finds that adolescents whose fathers engaged in weight conversations were significantly more likely to engage in dieting and UWCBs than adolescents whose fathers did not. Thus, it may be important to educate fathers to avoid any form of weight-related conversations with their adolescents. | [3.0, 4.0, 4.0, 4.0, 4.0] | Medicine | train | 3.8 | tweets | 349679298631835648 |
10.1186/1471-2431-13-162 | Medicine_tweet_75 | What are the FSA @username doing about the high levels of aluminium found in UK baby milk? | We consider that the aluminium content of all infant formulas investigated herein is too high and especially so considering that these products constitute either all or a substantial proportion of an infant's diet in the first months of their lives. | What are the FSA @username doing about the high levels of aluminium found in UK baby milk? | The concentration of aluminium in each of the 30 infant formulas is at least twice that which is recommended in the European Union for drinking water (50 μg/L) and in 14 of the milks it exceeds the maximum admissible level for drinking water of 200 μg/L . We consider that the aluminium content of all infant formulas investigated herein is too high and especially so considering that these products constitute either all or a substantial proportion of an infant's diet in the first months of their lives. Based upon the criteria for drinking water they are not fit for human consumption and they contravene article 5 of the Food Safety Act which states that 'infant formulas should not contain anything which might endanger the health of infants and young children' . | [4.0, 2.0, 2.0, 5.0, 4.0] | Medicine | train | 5 | tweets | 388456794898829313 |
10.1126/scitranslmed.aab1290 | Medicine_tweet_76 | Drug Delivers Estrogen Selectively to the Brain to Treat Neurological Disorders #SciTM via @username @username | We reveal the therapeutic potential of DHED on estrogen deficiency-associated neurological disorders and psychiatric conditions without encountering adverse systemic actions that are typically seen with the direct use of estrogens. | Drug Delivers Estrogen Selectively to the Brain to Treat Neurological Disorders #SciTM via @username @username | Although this method provides increased selectivity in CNS delivery of the hormone, it still generates elevated levels of the hormone in the periphery with substantial uterotrophic side effects and sustained high circulating estrogen levels even after acute dosing . We reveal the therapeutic potential of DHED on estrogen deficiency-associated neurological disorders and psychiatric conditions without encountering adverse systemic actions that are typically seen with the direct use of estrogens. The reductive bioactivation of DHED to E 2 proceeds through hydride transfer from the coenzyme NADPH to the C1 position of the C1-C2 double bond of DHED's Aring that is conjugated to the 3-carbonyl group. | [4.0, 4.0, 4.0, 4.0, 4.0] | Medicine | train | 4 | tweets | 623932971901435906 |
10.1001/jama.2013.285112 | Medicine_tweet_79 | Tobacco control responsible for 30% of the increase in life expectancy in US in past 50 years. | In women, life expectancy at age 40 years increased 5.4 years (from 37.4 to 42.7 years), but without tobacco control, it would have been projected to increase by only 3.8 years (from 37.3 to 41.2 years). | Tobacco control responsible for 30% of the increase in life expectancy in US in past 50 years. | Hence, 2.3 years (CR, 1.8-2.5) or 30% (CR, 23%-32%) of improved life expectancy for men is projected to be associated with tobacco control. In women, life expectancy at age 40 years increased 5.4 years (from 37.4 to 42.7 years), but without tobacco control, it would have been projected to increase by only 3.8 years (from 37.3 to 41.2 years). Tobacco control appears to be associated with 1.6 years (CR, 1.4-1.7) of the improvement in life expectancy for women or 29% (CR, 25%-32%) of the gain. | [3.0, 4.0, 4.0, 4.0, 4.0] | Medicine | train | 3.8 | tweets | 421008651134844928 |
10.1186/s13293-018-0204-8 | Medicine_tweet_8 | More attention needs to be dedicated to investigating the varied development, function, and biology in lower urinary tract between females and males on a cellular level, a new review paper explains. #sexdifferences | This review serves to characterize the current understanding of biological sex differences between female and male lower urinary tracts, while identifying areas for future research. | More attention needs to be dedicated to investigating the varied development, function, and biology in lower urinary tract between females and males on a cellular level, a new review paper explains. #sexdifferences | Recognizing that cell biology is not uniform, especially in the lower urinary tract of females and males, is crucial for providing context and relevance for diverse fields of biomedical investigation. This review serves to characterize the current understanding of biological sex differences between female and male lower urinary tracts, while identifying areas for future research. First, the differences in overall cell populations are discussed in the detrusor smooth muscle, urothelium, and trigone. | [4.0, 5.0, 4.0, 5.0, 3.0] | Medicine | train | 4.2 | tweets | 1057993659721883648 |
10.1192/bjp.bp.111.101196 | Medicine_tweet_80 | Fascinating piece on ADHD in elderly people Discusses prevalence rates of #ADHD in older adults. | Given the chronicity and impact of the ADHD one might have expected that older adults with ADHD experience impairments in these three areas. | Fascinating piece on ADHD in elderly people Discusses prevalence rates of #ADHD in older adults. | Another striking finding is that older adults with ADHD did not differ in living situation, level of education and income compared to older adults without ADHD. Given the chronicity and impact of the ADHD one might have expected that older adults with ADHD experience impairments in these three areas. There are several explanations for this finding. | [2.0, 2.0, 2.0, 2.0, 3.0] | Medicine | train | 2.2 | tweets | 654074801280167936 |
10.1038/s41562-018-0366-8 | Medicine_tweet_81 | NEW RESEARCH finds that memory consolidation and reconsolidation share common behavioural and neurochemical mechanisms From researchers at @username & #UniversityofRegensburg | The similarity in the time-course changes in the E/I ratio and behavioural performance between reconsolidation and consolidation is in accordance with the hypothesis that these two processes have similar or some common underlying mechanisms. | NEW RESEARCH finds that memory consolidation and reconsolidation share common behavioural and neurochemical mechanisms From researchers at @username & #UniversityofRegensburg | First, although it has been controversial whether reactivation and reconsolidation of skill learning occurs in humans, our results show that reactivation and reconsolidation indeed occur in humans with VPL, a type of procedural learning. The similarity in the time-course changes in the E/I ratio and behavioural performance between reconsolidation and consolidation is in accordance with the hypothesis that these two processes have similar or some common underlying mechanisms. Thus, the E/I ratio decreases from high after the end of training or reactivation to baseline levels 3.5 hour later, thereby reflecting that both consolidation and reconsolidation are associated with decreases in the degree of plasticity. | [5.0, 4.0, 5.0, 4.0] | Medicine | train | 4.5 | tweets | 1016660830346244096 |
10.1073/pnas.1515528113 | Medicine_tweet_83 | On missing the opportunity to nearly eradicate cervical and #HPV-induced #cancer @username | Because of interstate migration and the long duration between HPV infection and resultant cervical cancer, much of the benefit of vaccination will be realized beyond a state's borders. | On missing the opportunity to nearly eradicate cervical and #HPV-induced #cancer @username | Because of the impact of herd immunity, any expansion in coverage will be much more effective in reducing cancer incidence and healthcare costs if targeted in those states with the lowest coverage. Because of interstate migration and the long duration between HPV infection and resultant cervical cancer, much of the benefit of vaccination will be realized beyond a state's borders. Therefore, both cervical cancer incidence and expenditure can be substantially reduced if the states coordinate policies to promote expansion of coverage, particularly for the new nonavalent vaccine. | [3.0, 3.0, 2.0, 1.0] | Medicine | train | 2.25 | tweets | 722161035726049280 |
10.3945/an.111.000513 | Medicine_tweet_85 | Apples and their relationship to human health-#fructose from fruit different from added fructose- | In men, the risk reduction was 19% in the group consuming >54 g compared to no apple intake . | Apples and their relationship to human health-#fructose from fruit different from added fructose- | A group of Finnish women consuming >71 g of apple/d experienced a 43% reduction in coronary mortality compared to women who did not eat apples. In men, the risk reduction was 19% in the group consuming >54 g compared to no apple intake . These findings were consistent with prior data showing reduced coronary mortality in elderly Dutch men (65-84 y) who consumed apples (average 69 g/d) compared to men who had little or no apple intake . | [1.0, 2.0, 2.0, 4.0, 4.0] | Medicine | train | 4 | tweets | 199840951517196289 |
10.1007/s10803-016-2729-1 | Medicine_tweet_86 | We need more police training about autism Remember hearing Dennis Debbaudt talk about this | Further, 47% of police reported that they were 'fairly knowledgeable' about ASD. | We need more police training about autism Remember hearing Dennis Debbaudt talk about this | More specifically, police respondents were largely satisfied (42%) with their dealings with the ASD community; with only 21% reporting dissatisfaction (37% gave a neutral response). Further, 47% of police reported that they were 'fairly knowledgeable' about ASD. However, the possibility of a discrepancy between police self-reported competence and professional conduct in practice cannot be discounted. | [2.0, 2.0, 3.0, 4.0, 3.0] | Medicine | train | 2.8 | tweets | 697728625634897920 |
10.1016/j.cels.2017.12.013 | Medicine_tweet_88 | Multi #omics analysis of individuals during periods of weight loss & gain #systemsbiology | Extensive multi-omic profiling of the blood and microbiomes of healthy and insulin-resistant humans as they gain and lose weight reveals insights into the systemic impacts of weight gain. | Multi #omics analysis of individuals during periods of weight loss & gain #systemsbiology | Graphical Abstract Highlights d Analysis of insulin-sensitive and -resistant individuals across multiple omes d We reveal molecular changes in the human body after modest short-term weight gain d Reversal of short-term weight gain eliminates negative molecular alterations d Open-access multi-omic resource for further bioinformatics developments Extensive multi-omic profiling of the blood and microbiomes of healthy and insulin-resistant humans as they gain and lose weight reveals insights into the systemic impacts of weight gain. As such, a more comprehensive molecular profiling approach may offer novel insights into the diversity of systemic responses to the increase in body fat stores. | [3.0, 5.0, 4.0, 5.0, 4.0] | Medicine | train | 4.2 | tweets | 954036430682165248 |
10.1001/jamaophthalmol.2017.4512 | Medicine_tweet_89 | In Women's Health Initiative participants with #cataract, those with #cataractsurgery may have longer survival. | Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care. | In Women's Health Initiative participants with #cataract, those with #cataractsurgery may have longer survival. | Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care. 6 Furthermore, the WHI database contains information on total and cause-specific mortality, which is not available in other large databases of patients with cataract surgery in the United States. 7 These factors make the WHI an ideal cohort in which to examine the interplay between eye disease and a wide variety of systemic and lifestyle factors in US women. | [3.0, 3.0, 3.0, 2.0] | Medicine | train | 2.75 | tweets | 923579988414226432 |
10.1001/jamapediatrics.2013.455 | Medicine_tweet_9 | Longer breastfeeding is associated with improved cognition at age 3 and 7. Again, data are observational. #needrcts | RESULTS Adjusting for sociodemographics, maternal intelligence, and home environment in linear regression, longer breastfeeding duration was associated with higher Peabody Picture Vocabulary Test score at age 3 years (0.21; 95% CI, 0.03-0.38 points per month breastfed) and with higher intelligence on the Kaufman Brief Intelligence Test at age 7 years (0.35; 0.16-0.53 verbal points per month breastfed; and 0.29; 0.05-0.54 nonverbal points per month breastfed). | Longer breastfeeding is associated with improved cognition at age 3 and 7. Again, data are observational. #needrcts | MAIN EXPOSURE Duration of any breastfeeding to age 12 months. RESULTS Adjusting for sociodemographics, maternal intelligence, and home environment in linear regression, longer breastfeeding duration was associated with higher Peabody Picture Vocabulary Test score at age 3 years (0.21; 95% CI, 0.03-0.38 points per month breastfed) and with higher intelligence on the Kaufman Brief Intelligence Test at age 7 years (0.35; 0.16-0.53 verbal points per month breastfed; and 0.29; 0.05-0.54 nonverbal points per month breastfed). Breastfeeding duration was not associated with Wide Range Assessment of Memory and Learning scores. | [5.0, 4.0, 5.0, 4.0, 4.0] | Medicine | train | 4.4 | tweets | 370897635525136387 |
10.14814/phy2.13617 | Medicine_tweet_90 | Exposing preschoolers to an hour of bright light before bedtime almost completely shuts down their production of the sleep-promoting hormone melatonin. | The magnitude of the circadian response to light may differ in young children and therefore understanding the phase shifting effects of light in this age group is necessary to support age-based recommendations for evening light exposure. | Exposing preschoolers to an hour of bright light before bedtime almost completely shuts down their production of the sleep-promoting hormone melatonin. | Although this study was not designed to assess changes in circadian timing (phase shifts) in response to an experimental light stimulus, this represents an area of rich investigation. The magnitude of the circadian response to light may differ in young children and therefore understanding the phase shifting effects of light in this age group is necessary to support age-based recommendations for evening light exposure. Because the early childhood years are a sensitive and vulnerable window in human development (Center on the Developing Child, 2010), future research should investigate the role of evening light exposure in health and disease in early life. | [5.0, 2.0, 2.0, 2.0, 3.0] | Medicine | train | 2.8 | tweets | 971015501236375552 |
10.1098/rsos.171474 | Medicine_tweet_91 | More evidence that playing violent video games is not associated with violent or aggressive behaviour in real life – this time from a registered report with a large sample of UK teens (N = 1,004). | Preregistered sensitivity and exploratory analyses demonstrated this finding was consistent across three different operationalizations of violent game content and two ways of measuring key adolescent behaviours relating to aggressive and prosocial behaviours. | More evidence that playing violent video games is not associated with violent or aggressive behaviour in real life – this time from a registered report with a large sample of UK teens (N = 1,004). | Results from these confirmatory analyses provided evidence that adolescents' recent violent video game play is not a statistically or practically significant correlate of their aggressive behaviour as judged by carers. Preregistered sensitivity and exploratory analyses demonstrated this finding was consistent across three different operationalizations of violent game content and two ways of measuring key adolescent behaviours relating to aggressive and prosocial behaviours. In other words, we found adolescents were not more or less likely to engage in aggressive or prosocial behaviours as a function of the amount of time they devoted to playing violent games. | [2.0, 2.0, 4.0, 4.0] | Medicine | train | 3 | tweets | 1095826758455066624 |
10.1038/s41467-018-07557-4 | Medicine_tweet_92 | Latest from @username, up to 70% of our #arctic infrastructure is at risk of #climatechange induced permafrost degradation, affecting over 4 million people.
I'm getting a sinking feeling about all of this!
| Detrimental effects on engineered structures, socio-economic activities, and natural systems can, therefore, all be expected throughout the permafrost domain under climate warming 1 , particularly in high-risk areas with substantial urban and industrial centres such as Vorkuta and Novyi Urengoy in hot spots of infrastructure hazard in the Russian Arctic ( Fig. | Latest from @username, up to 70% of our #arctic infrastructure is at risk of #climatechange induced permafrost degradation, affecting over 4 million people.
I'm getting a sinking feeling about all of this!
| The potential harm to industrial facilities could be larger than estimated (pipelines: estimate = 32%, range = 24-70%; industrial areas: estimate = 25%, range = 20-64%) ( Fig. Detrimental effects on engineered structures, socio-economic activities, and natural systems can, therefore, all be expected throughout the permafrost domain under climate warming 1 , particularly in high-risk areas with substantial urban and industrial centres such as Vorkuta and Novyi Urengoy in hot spots of infrastructure hazard in the Russian Arctic ( Fig. adaptation strategies and structures such as insulation and thermosyphons that were not considered in this pan-Arctic study) can to some extent address both human-induced and naturally caused problems, their economic cost may be prohibitive at regional scales 32 . | [3.0, 4.0, 4.0, 3.0] | Medicine | train | 3.5 | tweets | 1073308524707381248 |
10.3945/jn.113.188441 | Medicine_tweet_93 | What to eat when working those long hours at the office? Study shows instant noodles increase risk of heart disease - | However, the stronger association between instant noodle consumption $2 times/wk and metabolic syndrome among women after excluding participants taking blood pressure-lowering and lipid-lowering medications or who had a history of diabetes mellitus might indicate the robustness of that association. | What to eat when working those long hours at the office? Study shows instant noodles increase risk of heart disease - | First, we cannot infer a causal relation given our cross-sectional study design. However, the stronger association between instant noodle consumption $2 times/wk and metabolic syndrome among women after excluding participants taking blood pressure-lowering and lipid-lowering medications or who had a history of diabetes mellitus might indicate the robustness of that association. Second, dietary pattern construction by principal components analysis may be limited by subjectivity in the proper number of extracted factors and food-grouping methods . | [3.0, 4.0, 1.0, 2.0, 1.0] | Medicine | train | 2.2 | tweets | 502708776219459586 |
10.1039/c3cs60122f | Medicine_tweet_94 | Lab notebooks in the digital era: ELNs in record keeping for chemistry & other sciences: Bird, Willoughby, @username | They note that the knowledge that a laboratory notebook comprises can be critical for establishing evidence in support of intellectual property rights and for refuting claims of research misconduct. | Lab notebooks in the digital era: ELNs in record keeping for chemistry & other sciences: Bird, Willoughby, @username | 119 He also presented a financial justification for electronic management of IP records. They note that the knowledge that a laboratory notebook comprises can be critical for establishing evidence in support of intellectual property rights and for refuting claims of research misconduct. 120 It is perhaps a sign of the times that this is one of only two publications in this survey to mention defence against claims of misconduct. | [2.0, 3.0, 1.0, 3.0, 5.0] | Medicine | train | 3 | tweets | 366952261068406785 |
10.1111/dom.13336 | Medicine_tweet_95 | Girls with menarche at age 10 years or younger are 18% more likely to develop T2D compared with girls with it at age 13 years or older. Nulliparous women are at greater risk T2D vs. women who have had at least 2. @username @username | Non-linear associations with diabetes were observed for age at menarche, parity and age at first birth. | Girls with menarche at age 10 years or younger are 18% more likely to develop T2D compared with girls with it at age 13 years or older. Nulliparous women are at greater risk T2D vs. women who have had at least 2. @username @username | Results: Over a median follow-up of 9 years, 4073 cases of diabetes were reported. Non-linear associations with diabetes were observed for age at menarche, parity and age at first birth. Notable trends in the prevalence of female-specific risk factors such as an increase in the rate of gestational diabetes (itself, a major risk factor for diabetes) observed in populations, 11 and a decline in the mean age of menarche 12 (in part attributable to the increase in childhood obesity) have added to the speculation that they may play a role in the diabetes pandemic. | [4.0, 2.0, 1.0, 3.0] | Medicine | train | 2.5 | tweets | 992436255689408512 |
10.1177/0146167214565055 | Medicine_tweet_96 | Does having particular types of goals provoke superstitious behavior more so than others? | We suggest that this internal sense of judgment and control for learning goals means that people do not believe that superstition (contingent on external forces such as luck) will facilitate the achievement of learning goals, and will not use superstitious behavior to facilitate their achievement. | Does having particular types of goals provoke superstitious behavior more so than others? | Intrinsic motivation leads to a perception of internal (rather than external) locus of control , which is consistent with the idea that learning goals are judged internally-by oneself. We suggest that this internal sense of judgment and control for learning goals means that people do not believe that superstition (contingent on external forces such as luck) will facilitate the achievement of learning goals, and will not use superstitious behavior to facilitate their achievement. In Study 5, conditioning trials established positive or negative associations with several items. | [2.0, 5.0, 4.0] | Medicine | train | 2 | tweets | 560262826816983041 |
10.1016/j.socscimed.2018.10.008 | Medicine_tweet_97 | Important paper out today with @username. Male infants and birth complications increase incidence of PND. #pnd #ppd #babyboy #obgyn #episiotomy #csection #difficultbirth #inflammation #evolutionarymedicine | We found the odds of PND increased by 71-79% when male infants were born compared to female infants. | Important paper out today with @username. Male infants and birth complications increase incidence of PND. #pnd #ppd #babyboy #obgyn #episiotomy #csection #difficultbirth #inflammation #evolutionarymedicine | We found the odds of PND increased by 71-79% when male infants were born compared to female infants. The occurrence of birth complications increased the odds of PND by 174% compared to having no complications. Testing for interaction effects found that, while always at increased risk of PND, women with a tendency towards symptoms of depression, anxiety, and stress at other points in the life course had reduced odds of PND when experiencing birth complications, suggesting such women may elicit greater support. | [4.0, 5.0, 3.0, 5.0, 5.0] | Medicine | train | 4.4 | tweets | 1058267550939668481 |
10.1093/eurpub/cky178 | Medicine_easy_0 | "We estimated that each 1% reduction in real public health expenditure per-capita corresponded to a 0.5 percentage points reduction in MMR coverage." | We estimated that each 1% reduction in real public health expenditure per-capita corresponded to a 0.5 percentage points reduction in MMR coverage. | "Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles," the authors wrote. "We estimated that each 1% reduction in real public health expenditure per-capita corresponded to a 0.5 percentage points reduction in MMR coverage." "Many people were not hired anymore as staff." | Our analysis suggests that austerity measures adopted in Italy contributed significantly to the resurgence of measles. We estimated that each 1% reduction in real public health expenditure per-capita corresponded to a 0.5 percentage points reduction in MMR coverage. In the worst affected regions, which faced up to 5% cuts, this would equate to a 2.5 percentage point fall in coverage. | [5] | Medicine | train | 5 | news | http://ct.moreover.com/?a=37159214862&p=1pl&v=1&x=CcPjjUifeL13VJ3H086Sjg |
10.1001/jamasurg.2014.2253 | Medicine_easy_2 | The authors acknowledge limitations of their study, including that the decreasing rate of PTR could have primarily been the result of more effective systemic therapy or of greater reluctance by surgeons to operate on patients with asymptomatic stage IV CRC. | First, the decreasing rate of PTR could have been primarily the result of more effective systemic therapy or of greater reluctance among surgeons to operate on patients with asymptomatic stage IV CRC. | Results also show the median survival rate for stage IV CRC improved from 8.6 percent in 1988 to 17.8 percent in 2009. The authors acknowledge limitations of their study, including that the decreasing rate of PTR could have primarily been the result of more effective systemic therapy or of greater reluctance by surgeons to operate on patients with asymptomatic stage IV CRC. "Despite the availability of more effective chemotherapeutic options, a considerable number of patients with stage IV CRC continue to undergo PTR. | Our study has several limitations. First, the decreasing rate of PTR could have been primarily the result of more effective systemic therapy or of greater reluctance among surgeons to operate on patients with asymptomatic stage IV CRC. The extent to which these factors contributed to the observed decreasing PTR rate is unknown. | [5] | Medicine | train | 5 | news | http://www.sciencedaily.com/releases/2015/01/150114115508.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1080/02770903.2017.1299757 | Medicine_easy_3 | Over a third (42.4 per cent) of students prescribed a short-acting '?2-agonist' inhaler felt uncomfortable using it at school, and 29.2 per cent reported not using this inhaler when wheezy. | Over a third (42.4%) of students prescribed a short-acting β2-agonist inhaler felt uncomfortable using it at school, and 29.2% (n = 173) reported not using this inhaler when wheezy. | The study, published in the Journal of Asthma, found that suboptimal asthma control was reported by 49.6 per cent of the students. Over a third (42.4 per cent) of students prescribed a short-acting '?2-agonist' inhaler felt uncomfortable using it at school, and 29.2 per cent reported not using this inhaler when wheezy. 56.4 per cent of those with regular inhaled corticosteroids did not take them as prescribed, and 41.7 per cent did not know what this inhaler was for. | Suboptimal asthma control was reported by 49.6% of students. Over a third (42.4%) of students prescribed a short-acting β2-agonist inhaler felt uncomfortable using it at school, and 29.2% (n = 173) reported not using this inhaler when wheezy. 56.4% (n = 220) of those with regular inhaled corticosteroids did not take them as prescribed, and 41.7% did not know what this inhaler was for. | [5] | Medicine | train | 5 | news | http://healthmedicinet.com/news/asthmatic-schoolchildren-are-uncomfortable-using-their-inhalers/ |
10.1001/jamaneurol.2017.4618 | Medicine_easy_4 | Multivariable logistic regression analysis indicated that the presence of acute brain lesions was independently associated with development of delayed neurological sequelae. | Multivariable logistic regression analysis indicated that the presence of acute brain lesions was independently associated with development of delayed neurological sequelae (adjusted odds ratio, 13.93; 95% CI, 7.16-27.11; P < .001). | A total of 101 patients (26.1 percent) had delayed neurological sequelae. Multivariable logistic regression analysis indicated that the presence of acute brain lesions was independently associated with development of delayed neurological sequelae. The sensitivity and specificity of acute brain lesions to assess the probability of delayed neurological sequelae were 75.2 percent and 90.2 percent, respectively. | Multivariable logistic regression analysis indicated that the presence of acute brain lesions was independently associated with development of delayed neurological sequelae (adjusted odds ratio, 13.93; 95% CI, 7.16-27.11; P < .001). The sensitivity and specificity of acute brain lesions to assess the probability of delayed neurological sequelae were 75.2% (95% CI, 66.8%-83.7%) and 90.2% (95% CI, 86.8%-93.7%), respectively. In addition, the positive and negative predictive values were 73.1% (95% CI, 64.6%-81.6%) and 91.2% (95% CI, 87.9%-94.5%), respectively. | [5] | Medicine | train | 5 | news | http://www.diagnosticimaging.com/article/imaging-may-identify-potential-delayed-neurological-sequelae-after-carbon-monoxide-poisoning |
10.1377/hlthaff.2012.1030 | Medicine_easy_5 | Even among lower-risk pregnancies, "in which more limited variation might be expected," hospital cesarean rates varied 15-fold, from 2 percent to 37 percent. | Even for women with lower-risk pregnancies, in which more limited variation might be expected, cesarean rates varied fifteenfold, from 2.4 percent to 36.5 percent. | C-Section Rates Vary Widely Between Hospitals, Study Finds Rates ranged from 7 percent to 70 percent depending on the hospital. Even among lower-risk pregnancies, "in which more limited variation might be expected," hospital cesarean rates varied 15-fold, from 2 percent to 37 percent. "Because Medicaid pays for nearly half of U.S. births, government efforts to decrease variation are warranted." | Working with 2009 data from 593 US hospitals nationwide, we found that cesarean rates varied tenfold across hospitals, from 7.1 percent to 69.9 percent. Even for women with lower-risk pregnancies, in which more limited variation might be expected, cesarean rates varied fifteenfold, from 2.4 percent to 36.5 percent. Thus, vast differences in practice patterns are likely to be driving the costly overuse of cesarean delivery in many US hospitals. | [5] | Medicine | train | 5 | news | http://abcnews.go.com/Health/section-rates-vary-widely-hospitals-study-finds/story?id=18656847 |