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10.1126/scisignal.aac5472 | Medicine_591 | We need more studies to make sure they were not losing bone or muscle mass." | Trehalose stimulated an increase in AMPK (Thr 172 ) phosphorylation within 30 min, and this increase was sustained throughout the 4-hour time course (Fig. | "We know the mice that received drinking water with three percent trehalose lost weight, and we suspect that weight loss was due to loss of fat, but we can't be certain that's the only effect. We need more studies to make sure they were not losing bone or muscle mass." In the meantime, DeBosch advises his patients to avoid foods with added fructose, especially sugar-sweetened beverages. | Reduced ATP concentration should increase the AMP/ATP ratio, leading to the phosphorylation at Thr 172 and activation of AMPK, an energy-sensing kinase that stimulates autophagy . Trehalose stimulated an increase in AMPK (Thr 172 ) phosphorylation within 30 min, and this increase was sustained throughout the 4-hour time course (Fig. In contrast, AMPK activation was at basal levels in cells that had not been exposed to trehalose (0 in Fig. | [1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/8epGo0Xrlqg/ |
10.1186/s13054-014-0480-6 | Medicine_592 | Instead of creating another EMR alert, data should be tethered to a decision support system so treatment is proactive and forecasted, rather than reactive. | This strategy requires that initial antibiotic choices be guided by local antibiotic resistance patterns and laboratory test results (including Gram staining), rapidly yielding identities of likely responsible pathogens. | I get 100 alerts a day," Dr. Siddiqui said, adding that the industry needs to do a better job of making EMR data actionable without contributing to clinician alert fatigue. Instead of creating another EMR alert, data should be tethered to a decision support system so treatment is proactive and forecasted, rather than reactive. The decision support solution can analyze EMR data to identify patients at-risk for developing complications down the road so that decisions can be made and communicated faster. | In general, the first goal can be accomplished by rapidly identifying patients with infection and starting empirical therapy likely to treat the institution's most common etiological agents. This strategy requires that initial antibiotic choices be guided by local antibiotic resistance patterns and laboratory test results (including Gram staining), rapidly yielding identities of likely responsible pathogens. Therefore, every effort | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34230514886&p=1pl&v=1&x=sTidMUp-CQ82HZ8HjR4Fgw |
10.1093/cercor/bhp008 | Medicine_593 | Das heisst nach einer eindringlichen ersten Testphase also konkret: Zum dudeligen Bass kommen nach und nach auch noch andere Bass-Gitarren, die den Sex-Soundtrack rhythmisch upgraden sollen. | An additional notable effect of valence was found in the substantia nigra. | Die ernuchternde Antwort: Die App passt lediglich den Rhythmus dieses einen Songs an. Das heisst nach einer eindringlichen ersten Testphase also konkret: Zum dudeligen Bass kommen nach und nach auch noch andere Bass-Gitarren, die den Sex-Soundtrack rhythmisch upgraden sollen. Entsprechend steigert er die Geschwindigkeit. | An area of overlap between familiarity and valence responses was in the ventral lateral thalamic nucleus. An additional notable effect of valence was found in the substantia nigra. As noted above in the Materials and Methods, the familiarity, autobiographical salience, and valence regressors were correlated moderately prior to orthogonalization ( Supplementary Fig. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33839584826&p=1pl&v=1&x=5ADwEoil4iW7ttlnMQrtQA |
10.1016/j.annemergmed.2018.06.042 | Medicine_594 | Making sure everyone can hear you, understand you, and is physically able to follow safety procedures will speed the decontamination process and limit toxic exposure, especially for children, the elderly and the most vulnerable victims," said Robert P. Chilcott, PhD, professor at the University of Hertfordshire (UK) and lead study author. | A ladder pipe operator stated that "It was pretty tough keeping those people in really cold water, but usually we were able to communicate with the guys standing on the end of it demonstrating to make sure you catch as much of your body as you can. | "Should a large-scale chemical exposure occur, clear communication from first responders can save lives. Making sure everyone can hear you, understand you, and is physically able to follow safety procedures will speed the decontamination process and limit toxic exposure, especially for children, the elderly and the most vulnerable victims," said Robert P. Chilcott, PhD, professor at the University of Hertfordshire (UK) and lead study author. "First responder staffing levels and resources may need to be re-evaluated in order to avoid casualties and ensure safe and effective rapid response." | It was noted that the wound dressing packs had been difficult to distribute and that firefighters wearing full personal protective equipment had needed to intervene by picking up dressing packs from the floor to hand to the volunteers. A ladder pipe operator stated that "It was pretty tough keeping those people in really cold water, but usually we were able to communicate with the guys standing on the end of it demonstrating to make sure you catch as much of your body as you can. Having a facecloth would have been really useful." | [2.0, 2.0, 2.0, 1.0, 3.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=34969890416&p=1pl&v=1&x=uZ-qm2MubdaW8Fvq03jOmA |
10.1016/j.stemcr.2014.02.010 | Medicine_595 | As they suspected, when cells lacked GRP78 on their surfaces, they didn't respond to CRIPTO. | Significantly, the self-renewal potential of these cells is evident in their capacity to reconstitute fully arborized mammary epithelial outgrowths in tertiary transplants that respond normally to pregnancy ( Figure S4G ). | When they instead boosted levels of CRIPTO, the stem cell colony grew as new stem cells were produced more often than differentiated cells. As they suspected, when cells lacked GRP78 on their surfaces, they didn't respond to CRIPTO. With the new ability to isolate and sustain mammary stem cells, Spike and Gray hope they can uncover details on exactly what cellular programs CRIPTO and GRP78 activate. | Outgrowths from transplanted GRP78 high cells resemble endogenous mammary glands in FACS analyses including the presence of GRP78 high cells within the CD24 expressing mammary epithelium ( Figure S4F) . Significantly, the self-renewal potential of these cells is evident in their capacity to reconstitute fully arborized mammary epithelial outgrowths in tertiary transplants that respond normally to pregnancy ( Figure S4G ). We also identify a diffuse, small, and variable population of GRP78 ''superpositive'' (GRP78 high+ ) cells with intermediate performance in stem cell assays ( Figures S4D and S4E) . | [1.0, 2.0, 1.0, 2.0, 1.0] | Medicine | train | 1.4 | news | http://www.sciencedaily.com/releases/2014/05/140507100434.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1007/s10533-018-0502-6 | Medicine_597 | The downstream data showed an instant spike in copper released from the streambed, suggesting a direct connection between the stream's salt content and copper in the water. | For example, NO 3 -, DOC, and turbidity dynamics all b Fig. | In a similar set of observations in Washington, D.C.'s Rock Creek, the team observed notable spikes in cadmium, copper and zinc following other snowstorms. The downstream data showed an instant spike in copper released from the streambed, suggesting a direct connection between the stream's salt content and copper in the water. Salt ion concentrations can stay high for months following a storm, Kaushal added. | Developing a unified concept for chemical transport in catchments in response to hydrological events Analyzing how chemical cocktails respond similarly or differently over time can allow us to formulate a unified concept for catchment chemical transport in response to hydrologic events (e.g., based on common modes of transport, mobility, and reactivity for carbon, nutrients, redox sensitive metals, and ionic salts). For example, NO 3 -, DOC, and turbidity dynamics all b Fig. 9 There have been significant changes in sieved, EEA 2012; Jaworski, unpublished data; . | [1.0, 3.0, 1.0, 1.0] | Medicine | train | 1.5 | news | http://ct.moreover.com/?a=37871057373&p=1pl&v=1&x=AqaJhGfZgLtEdz5q-Bzr2Q |
10.1073/pnas.1308285110 | Medicine_598 | It's very hard to change people's minds, to convince people about life after death or not. | In contrast, the CAS3 period was distinguished by a clear increase in absolute power of low gamma ( Fig. | Will this study convince people, one way or the other, about the existence of life after death? It's very hard to change people's minds, to convince people about life after death or not. Are you planning further experiments to follow up? | A short burst of delta (0-5 Hz) waves separated the CAS2 and CAS3 periods and was associated with abruptly reduced beta and low-gamma (25-55 Hz) power. In contrast, the CAS3 period was distinguished by a clear increase in absolute power of low gamma ( Fig. During this period, all other bands showed further decline in power. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://news.nationalgeographic.com/news/2013/08/130814-near-death-brain-life-after-death-bright-light/ |
10.1001/jamasurg.2014.2253 | Medicine_6 | Our findings indicate potential overuse of PTR among these patients and highlight a need to better understand the clinical decisions and outcomes associated with that treatment," the authors conclude. | The use of PTR varied significantly according to both the demographic characteristics of the patients and clinical factors. | The authors acknowledge limitations of their study, including that the decreasing rate of PTR could have primarily been the result of more effective systemic therapy or of greater reluctance by surgeons to operate on patients with asymptomatic stage IV CRC. "Despite the availability of more effective chemotherapeutic options, a considerable number of patients with stage IV CRC continue to undergo PTR. Our findings indicate potential overuse of PTR among these patients and highlight a need to better understand the clinical decisions and outcomes associated with that treatment," the authors conclude. | Our population-based study demonstrated that the use of PTR in patients presenting with stage IV CRC has been decreasing over time, and a notable reduction in the PTR rate was observed in 2001. The use of PTR varied significantly according to both the demographic characteristics of the patients and clinical factors. Younger age, female sex, white race/ ethnicity, married status, residence in the South, higher tumor grade, and tumors located in the colon were associated with an increased likelihood of having undergone PTR. | [2.0, 4.0, 2.0, 1.0, 2.0] | Medicine | train | 2.2 | news | http://www.sciencedaily.com/releases/2015/01/150114115508.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1038/s41467-018-04355-w | Medicine_60 | "These results shed new light on tumor microenvironment functioning and, potentially, may lead to new approaches for targeting the metastases of this extremely aggressive disease," said Alessandro Porrello, PhD, researcher at UNC Lineberger and the study's first author. | By integrating multi-step genomics analyses with novel mouse models, we found that IMs are critical drivers of LUSC metastasis. | "It's important to understand that while there is so much focus on activating parts of the immune system to attack cancer, there is also a 'Jekyll and Hyde' process going on in most tumors," Pecot said. "These results shed new light on tumor microenvironment functioning and, potentially, may lead to new approaches for targeting the metastases of this extremely aggressive disease," said Alessandro Porrello, PhD, researcher at UNC Lineberger and the study's first author. By genetically modifying the expression of CCL2 in a metastasis model developed in their laboratory, they found low expression was linked to reduced metastases, while high expression was linked to enhanced metastatic features. | Discussion PD1/PD-L1 immune checkpoint inhibitors, while effective in several cancer types, provide only about 20% response rates in unselected LUSC patients 5 . By integrating multi-step genomics analyses with novel mouse models, we found that IMs are critical drivers of LUSC metastasis. This analysis clearly implicated CD14 and the IM-rich subset in the poor survival of LUSC patients. | [1.0, 3.0, 1.0, 1.0, 2.0] | Medicine | train | 1.6 | news | http://healthmedicinet.com/news/by-forming-clots-in-tumors-immune-cell-aids-lung-cancers-spread/ |
10.1177/1088868313497266 | Medicine_600 | The 400% increase in atheism is a stunning number, especially from a country with such a long history of religiosity and problems stemming from the tension between Protestants and Catholics. | The omnibus F was significant, F(3, 54) = 7.06, p < .001. | Hegarty also points out that the Catholic Church influences basically "everything" in Ireland, including government and education. The 400% increase in atheism is a stunning number, especially from a country with such a long history of religiosity and problems stemming from the tension between Protestants and Catholics. Hegarty also points out a trend toward "cultural Catholicism" in which people participate in the celebrations and rituals of the Catholic Church without actually believing in a personal God, and he says this trend is also on the rise. | Any effects that distorted the "true" intelligence-religiosity relation should be removed. The omnibus F was significant, F(3, 54) = 7.06, p < .001. Surprisingly, studies with restriction of range yielded an effect size (M = −.31) that was more negative than that of the 46 studies with no evident source of bias (M = −.14). | [3.0, 4.0, 1.0, 2.0, 1.0] | Medicine | train | 2.2 | news | http://guardianlv.com/2014/01/ireland-turning-atheist/ |
10.1016/j.eplepsyres.2018.10.003 | Medicine_601 | The study, led by Irazoqui's team at Purdue, found acid in the esophagus of animal models 100 percent of the time that they experienced sudden death during a seizure. | In one case the lag between electrodes was < 5 s. | Sitting up pushes the acid back down to the stomach with the help of gravity. The study, led by Irazoqui's team at Purdue, found acid in the esophagus of animal models 100 percent of the time that they experienced sudden death during a seizure. These findings propose another potential cause of death to investigate, as well as ideas for more targeted treatment. | In two cases the pH change occurred in < 10 s. In six animals in which there was a pH change and two recording electrodes, the average delay between the pH change on the electrodes was 15.2 18 min. In one case the lag between electrodes was < 5 s. Three times after death we observed a pool of liquid at the animal's mouth, which was never present in control animals (Figure 6a ). | [1.0, 1.0, 4.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=38210522649&p=1pl&v=1&x=GtiFUzqWGcBfarbO3gmxSQ |
10.1093/scan/nsu039 | Medicine_602 | Once you immerse yourself in other details, your mind will wander to something else entirely, and you won't be focused on the negative emotions as much." | This procedure allowed identification of the brain regions that showed increased activation in both conditions. | "But we found that instead of thinking about your emotions during a negative memory, looking away from the worst emotions and thinking about the context, like a friend who was there, what the weather was like, or anything else non-emotional that was part of the memory, will rather effortlessly take your mind away from the unwanted emotions associated with that memory. Once you immerse yourself in other details, your mind will wander to something else entirely, and you won't be focused on the negative emotions as much." This simple strategy, the study suggests, is a promising alternative to other emotion-regulation strategies, like suppression or reappraisal. | [Context vs SM] \ [Emotion vs SM]), in which the statistical activations maps of the two contributing contrasts (Context vs SM) and (Emotion vs SM) were inclusively masked with each other. This procedure allowed identification of the brain regions that showed increased activation in both conditions. Context vs SM and Emotion vs SM, respectively). | [1.0, 1.0, 1.0, 2.0] | Medicine | train | 1.25 | news | http://www.sciencedaily.com/releases/2014/04/140418141121.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.3758/s13420-015-0194-x | Medicine_603 | And now they completely ignore social information and they just use trial and error learning to open the door and extract the food," Logan explained. | Whilst the task did not involve tool making, we assume that any social learning mechanism found to play a role in the acquisition of novel foraging behavior is also likely to play a role in the acquisition of tool-making behavior. | But the researchers did strong evidence of social learning: if one crow sees a companion interacting with a particular area of the apparatus, reaching its bill through a door and pulling out a piece of boiled egg - the treat - the former is far more likely to try that particular door on either apparatus before choosing the other access options. And now they completely ignore social information and they just use trial and error learning to open the door and extract the food," Logan explained. Even if one crow is at an apparatus and tries unsuccessfully to open the door, if he or she sees another crow on the second apparatus actually solving the problem correctly, the first crow doesn't use that information. | We found no evidence that the choice of apparatus was influenced by the apparatus at which the interactions of others were observed suggesting the context specific effect generalized between apparatuses, as would be expected by stimulus enhancement, but not local Fig. Whilst the task did not involve tool making, we assume that any social learning mechanism found to play a role in the acquisition of novel foraging behavior is also likely to play a role in the acquisition of tool-making behavior. Since action-specific social learning mechanisms (e.g., imitation or emulation) would be required to account for the documented pattern of variation in New Caledonian crow tool types, that we found no action-specific effect in our diffusion experiment suggests that social learning resulting from observing another's tool-making activity is unlikely to explain tool type variation. | [1.0, 2.0, 2.0, 4.0, 1.0] | Medicine | train | 2 | news | http://www.sci-news.com/biology/science-new-caledonian-crows-corvus-moneduloides-social-learning-03219.html |
10.1073/pnas.1308939110 | Medicine_604 | He went on to say, "Just because a plant or animal trait is common today doesn't mean that it was bred into them from the beginning. | While the expression of the dominant allele in skin tissue results in white skin color, the recessive allele possesses one or more cis-acting and tissue-specific regulatory mutations that inhibit expression of BCDO2 in skin tissue. | In fact, it probably only became prevalent in domesticated chickens as late as 500 years ago. He went on to say, "Just because a plant or animal trait is common today doesn't mean that it was bred into them from the beginning. It demonstrates that the pets and livestock we know today-dogs, chickens, horses, cows-are probably radically different from the ones our great-great-grandparents knew." | As a result, a re-evaluation of all the early finds is necessary to establish the chronology and geography of chicken domestication. While the expression of the dominant allele in skin tissue results in white skin color, the recessive allele possesses one or more cis-acting and tissue-specific regulatory mutations that inhibit expression of BCDO2 in skin tissue. Provided that sufficient carotenoids are available in the diet, the recessive allele reduces carotenoid cleavage and allows them to be deposited in skin tissue leading to yellow skin . | [2.0, 1.0, 2.0, 1.0, 2.0] | Medicine | train | 1.6 | news | http://www.scienceworldreport.com/articles/14144/20140422/evolution-barnyard-chicken-ancient-bone-dna-reveals-rapid-changes.htm |
10.1111/ecoj.12256 | Medicine_605 | But it then reverses direction and keeps rising to the age of 70. | The average age in the MABEL sample is slightly higher at 45.4 years (11.7). | But don't worry, it doesn't last. But it then reverses direction and keeps rising to the age of 70. The findings show there really is a kind of midlife "crisis" in people's feelings of satisfaction with their lives. | The average (standard deviation) age of subjects in these data sets is 40.9 years (15.0) for the BHPS, 39.4 years (14.8) for HILDA and 40.5 years (14.5) for SOEP. The average age in the MABEL sample is slightly higher at 45.4 years (11.7). In the eyes of some researchers, particularly those from a psychology background, the single-item nature of our analysis is not necessarily ideal. | [1.0, 1.0, 2.0, 2.0] | Medicine | train | 1.5 | news | http://www.futurity.org/midlife-happiness-aging-1055032/ |
10.1177/1742395311429393 | Medicine_606 | Hyland told SELF that the treatments required her to be hooked up to a machine through a port in her chest. | [] Finally, anticipated stigma from healthcare providers may be associated with decreased patient satisfaction among people living with chronic illness. | Unfortunately, though, by October 2016, Hylandas body had started to reject the kidney, and, as per SELF, the then-25-year-oldas creatinine levels (aka waste that would normally be flushed out by your kidneys, the outlet explains) were considerably high. Hyland told SELF that the treatments required her to be hooked up to a machine through a port in her chest. As a result of the dialysis, Hyland said she lost a significant amount of weight, developed sciatica (severe lower back pain), experienced swelling in the face, and a spike in blood pressure that affected her vision. | Although not all chronic illnesses are concealable, people living with chronic illnesses who anticipate stigma may likewise be more likely to socially isolate themselves and therefore receive less social support. [] Finally, anticipated stigma from healthcare providers may be associated with decreased patient satisfaction among people living with chronic illness. People living with chronic illness who anticipate stigma from their healthcare providers may be less open about their symptoms and illness-related concerns with their healthcare providers. | [1.0, 3.0, 1.0, 2.0, 1.0] | Medicine | train | 1.6 | news | http://ct.moreover.com/?a=37953358997&p=1pl&v=1&x=Nd2HoaAt80ZWni3RqJtbgg |
10.1242/jeb.128165 | Medicine_607 | With some forward planning, it's easy to swap red meat for other animal products and non-meat alternatives that are healthier and more environmentally sustainable. | 4A-C) : the macropod measurements were higher than expected for nonruminants but lower than in ruminants. | Alternatively, a handful of dried shiitake mushrooms in your salad or stir-fry would fulfil your requirements. By making some of the changes above and increasing your intake of meat alternatives such as legumes, you'll also be boosting your levels of dietary fibre. With some forward planning, it's easy to swap red meat for other animal products and non-meat alternatives that are healthier and more environmentally sustainable. | However, CH 4 yield of M. fuliginosus and M. rufus per unit of DMI, GEI and dNDFi as well as related to body mass shows a different picture (Fig. 4A-C) : the macropod measurements were higher than expected for nonruminants but lower than in ruminants. The results facilitate a comparison with other herbivores that suggests that CH 4 production in macropods is not fundamentally different from that in other mammals, but is similarly low to that in, for example, horses when compared with ruminants, and lead to a hypothetical explanation for why physiological characteristics of macropods could be responsible for these low values. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39441990364&p=1pl&v=1&x=YxAD5qU8KM3Gmd7EgOopCA |
10.1038/s41598-017-00981-4 | Medicine_608 | Coated with platinum powder, each nanoelectrode has a rough surface texture, which improves its ability to pass signals. | 6d for ±100 mV), whereas, if the shape of the postsynaptic signals presumably originated from multiple PSPs (as in Fig. | "Our combination of the sensitivity and parallelism can benefit fundamental and applied neurobiology alike, including functional connectome construction and high-throughput electrophysiological screening," said Hongkun Park, PhD, the Mark Hyman Jr. professor of chemistry and professor of physics, and co-senior author of the paper. "The mapping of the biological synaptic network enabled by this long sought-after parallelization of intracellular recording also can provide a new strategy for machine intelligence to build next-generation artificial neural network and neuromorphic processors," added Donhee Ham, the Gordon McKay professor of applied physics and electrical engineering at the John A. Paulson School of Engineering and Applied Sciences (SEAS), and co-senior author of the paper. Coated with platinum powder, each nanoelectrode has a rough surface texture, which improves its ability to pass signals. | The number of synaptic connections mapped with this approach is summarized in Table 1 for eight patched cells. 6d for ±100 mV), whereas, if the shape of the postsynaptic signals presumably originated from multiple PSPs (as in Fig. The summary in Table 1 illustrates the variations in connectivity between the different cell cultures and patched neurons. | [1.0, 2.0, 2.0, 3.0, 1.0] | Medicine | train | 1.8 | news | http://ct.moreover.com/?a=40268623864&p=1pl&v=1&x=GnMfq6uP6rJXVXPwSsrPIg |
10.1111/cdev.12250 | Medicine_62 | The researchers conclude with this scary notion:
"The findings support the proposition that early adolescent attempts to gain status via pseudomature behavior are not simply passing annoyances of this developmental stage, but rather may signal movement down a problematic pathway and away from progress toward real psychosocial competence." | Alternatively, these teens may actually be later selecting partners as adults who are similar to themselves in terms of status-seeking behavior, and may thus find that their partners actually are ending relationships with them due to status concerns. | By the time these "cool" kids turned 23, many of them were having problems with criminal behavior and alcohol and marijuana use -- significantly more than the other subjects in the study, who were not ranked in the "cool" category at the study's onset. The researchers conclude with this scary notion:
"The findings support the proposition that early adolescent attempts to gain status via pseudomature behavior are not simply passing annoyances of this developmental stage, but rather may signal movement down a problematic pathway and away from progress toward real psychosocial competence." In other words, if you're acting extreme to look cool, chances are good that you might be the only one who thinks so. | These teens may then be likely to perceive social status as a primary reason for the formation or dissolution of important relationships (e.g., romantic relationships) going forward, whether or not this is actually the case. Alternatively, these teens may actually be later selecting partners as adults who are similar to themselves in terms of status-seeking behavior, and may thus find that their partners actually are ending relationships with them due to status concerns. In either case, these findings make clear that the status-seeking aspect of early adolescent pseudomature behavior displays long-term continuity that extends into a new and important relationship domain even across a span of nearly a decade. | [5.0, 4.0, 2.0, 2.0, 2.0] | Medicine | train | 2 | news | http://www.businessinsider.com/kids-who-were-cool-at-13-are-not-at-age-23-2015-7 |
10.1002/ijc.28956 | Medicine_63 | "However the risk of death due to melanoma in this age group is generally low except among a small proportion of cases whose melanomas were already more than 1 mm thick when diagnosed," Professor Green said. | As seen across all ages those diagnosed with lesions >1 mm were at higher risk of death of those with thin melanoma. | As expected in the state's sunny climate, young Queenslanders are still up to five times more likely to be diagnosed with melanoma than young people in the US or Europe. "However the risk of death due to melanoma in this age group is generally low except among a small proportion of cases whose melanomas were already more than 1 mm thick when diagnosed," Professor Green said. "This generally favourable outcome is likely due, in large part, to early detection, resulting from increased skin cancer awareness." | With regard to survival, Queensland melanoma patients in this young age group had virtually the same survival rate at around 96% as all Australians aged 0-19, 20- and 0-9 years from 199 to 200 and young adults aged 20-2 years in the USA, and better survival at 5 years than seen in Australians aged 60-69 (91%). As seen across all ages those diagnosed with lesions >1 mm were at higher risk of death of those with thin melanoma. The generally favourable outcome in Queensland is likely due in part to early detection resulting from increased skin cancer awareness. | [4.0, 4.0, 4.0, 4.0] | Medicine | train | 4 | news | http://www.healthcanal.com/cancers/skin-cancer/51127-melanoma-rates-dropping-in-young-queenslanders.html |
10.1111/1365-2656.12871 | Medicine_64 | Rabbits that survive infection with MYXV virus have lower rates of survival than rabbits not yet infected," says Dr. Wells. | The transition probabilities between the different disease states can be | "By explicitly modelling the complex way that diseases behave in rabbit populations we found an unexpected result. Rabbits that survive infection with MYXV virus have lower rates of survival than rabbits not yet infected," says Dr. Wells. "This is important because it confirms that MYXV virus weakens animals so that they have a lower resistance when subsequently exposed to RHDV disease. | Specifically, the categories for η DZ were (i) all individuals <90 days old, including η RHD = "maternal antibodies" AND/OR η MYXV = "antibodies against MYXV", (ii) η RHD = "susceptible" AND η MYXV = "susceptible" (individuals ≥90 days old), (iii) η RHD = "susceptible" AND η MYXV = "immune" (individuals ≥90 days old), (iv) η RHD = "immune" AND η MYXV = "susceptible" (individuals ≥90 days old) and (v) η RHD = "immune" AND η MYXV = "immune" (individuals ≥90 days old). The transition probabilities between the different disease states can be In the case of RHD, the equation was as follows: | [1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34506942217&p=1pl&v=1&x=OCP5j07SbNKK_Tx7JPH1Dw |
10.1001/jamapsychiatry.2018.1941 | Medicine_65 | The analysis showed that these functional connectivities underlie the relation between depressive problems and sleep quality. | D, The mediation implemented by functional connectivity from the depressive problems score on poor sleep quality (Pittsburgh Sleep Quality Index [PSQI] score; β = 0.0139; P < .001). | In the brains of those living with depressive problems, they discovered a strong connection between the dorsolateral prefrontal cortex (associated with short-term memory), the precuneus (associated with the self), and the lateral orbitofrontal cortex (associated with negative emotion). The analysis showed that these functional connectivities underlie the relation between depressive problems and sleep quality. The researchers conclude that increased functional connectivity among these brain regions provides a neural basis for how depression is related to poor sleep quality. | 3 77 ; P < .001; left middle cingulate and paracingulate gyri: r =0 .38 5;P < .001; left precuneus: r = 0.430; P < .001; left insula: r = 0.348; P < .001; and to 2 ROIs within the right middle cingulate and paracingulate gyri: r = 0.368 and r = 0.402; P < .001 for both), 7 links involving the anterior cingulate cortex (to the left supplementary motor area: r = 0.446; P < .001; right postcentral gyrus: r = 0.368; P < .001; temporal pole [middle temporal gyrus]: r = 0.338; Depression score D, The mediation implemented by functional connectivity from the depressive problems score on poor sleep quality (Pittsburgh Sleep Quality Index [PSQI] score; β = 0.0139; P < .001). The total assocation of the Depressive Problems score with the outcome shows that the regression coefficient 32 (β) of the Depressive Problems score on the PSQI score was high when the functional connectivities were not taken into account. | [4.0, 3.0, 3.0] | Medicine | train | 3.333333 | news | https://www.futurity.org/depression-sleep-problems-insomnia-1821432-2/ |
10.1186/s13578-015-0003-4 | Medicine_66 | We further found that PC increased H2S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. | Taken together, our results indicated that aging rat hearts suffered from I/R injury and PC did not improve this injury. | I/R also increased the release of cytochrome c and down-regulated the phosphorylation of PI3K, Akt and GSK-3b in the aging rat hearts. We further found that PC increased H2S production rate and CSE expressions, and protected young hearts from I/R-induced cardiomyocytes damage, all of which were disappeared in the aging hearts. Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. | PC did not change the above mentioned indexes in comparison with the I/R (Figures 3, 4, 5 and 6 ). Taken together, our results indicated that aging rat hearts suffered from I/R injury and PC did not improve this injury. H 2 S produced by CSE in cardiovascular system acted as a physiological cardiac function regulator, which protected the cardiac function in ischemic reperfusion or hypoxia . | [3.0, 4.0, 3.0, 5.0] | Medicine | train | 3.75 | news | http://www.technology.org/2015/03/22/a-novel-target-for-the-treatment-of-aging-cardiovascular-diseases/ |
10.4049/jimmunol.1800107 | Medicine_67 | Importantly, chemical inhibition and small interfering RNA (siRNA) knock-down of NLRP3 in primary human macrophages reduced IL-1B production in response to CLCs, suggesting that the inflammatory response occurs via the NLRP3 inflammasome pathway. | CLC-induced IL-1β in macrophages occurred through the activation of caspase-1 following the assembly of the NLRP3 inflammasome. | Additionally, CLCs were shown to promote inflammation in vivo, as evidenced by an increased tissue presence of IL-1b. Importantly, chemical inhibition and small interfering RNA (siRNA) knock-down of NLRP3 in primary human macrophages reduced IL-1B production in response to CLCs, suggesting that the inflammatory response occurs via the NLRP3 inflammasome pathway. However, until recently, they were believed to be inert by-products of eosinophil activity with no immune activation," says Eicke Latz, M.D., Ph.D. "This study suggests that degradation of eosinophils leaves behind remnants that sustain immune activity. | Here we show that CLCs are promptly phagocytosed in vitro by human macrophages, and this leads to the release of the pro-inflammatory cytokine IL-1β. CLC-induced IL-1β in macrophages occurred through the activation of caspase-1 following the assembly of the NLRP3 inflammasome. Furthermore, we show that CLCs promoted inflammation in vivo, characterized by neutrophil infiltration, phagocytosis of the crystals, and IL-1β release. | [3.0, 4.0, 3.0, 3.0, 5.0] | Medicine | train | 3.6 | news | http://ct.moreover.com/?a=38014682083&p=1pl&v=1&x=fA9J7idoQjbuZC8wnt8o2Q |
10.1186/1471-2431-13-162 | Medicine_68 | The results show high levels of aluminium in each of the 30 infant formulas. | This issue can only be resolved through future research on infant exposure to aluminium through formula feeds and other routes. | The results show high levels of aluminium in each of the 30 infant formulas. Professor Exley said: "Clearly the manufacturers of infant formulas are not concerned about reducing their content of aluminium and the extensive use of aluminium-based packaging for infant formulas seems to confirm this. "There are no adequate criteria upon which to base a safety level for aluminium in infant formulas and for this reason it would be sensible to take action to reduce the level of aluminium to a lowest practicable level. | However, these organisations, charged with the responsibility of protecting the public from additives in their food, need to recognise and emphasise that this value was determined for adults and, critically, it was not based upon any studies on humans, whether infants, adolescents or adults. This issue can only be resolved through future research on infant exposure to aluminium through formula feeds and other routes. However, precautionary practical solutions to this public health issue should now be sought. | [1.0, 4.0, 3.0, 2.0, 2.0] | Medicine | train | 2.4 | news | http://www.healthcanal.com/child-health/43790-action-needed-now-to-lower-the-content-of-aluminium-in-infant-formulas.html |
10.3945/an.111.000513 | Medicine_7 | However, the study found that you can significantly lower your risk for cardiovascular disease by eating fresh fruit, including apples. | In men, the risk reduction was 19% in the group consuming >54 g compared to no apple intake . | And a probiotic-rich diet supports diverse gut microbiome, which can potentially protect you from cardiac conditions and autoimmune diseases, among other benefits that scientists are still uncovering. However, the study found that you can significantly lower your risk for cardiovascular disease by eating fresh fruit, including apples. Apples Lower Cholesterol Shutterstock You probably don't spending much time thinking about cholesterol because it's something only older folks need to worry about, right? | A group of Finnish women consuming >71 g of apple/d experienced a 43% reduction in coronary mortality compared to women who did not eat apples. In men, the risk reduction was 19% in the group consuming >54 g compared to no apple intake . These findings were consistent with prior data showing reduced coronary mortality in elderly Dutch men (65-84 y) who consumed apples (average 69 g/d) compared to men who had little or no apple intake . | [3.0, 4.0, 4.0, 4.0, 5.0] | Medicine | train | 4 | news | http://ct.moreover.com/?a=40250485393&p=1pl&v=1&x=uqRXZJPaxyAilrC1dCICVA |
10.1186/1471-2431-13-162 | Medicine_70 | "Since manufacturers are not willing to address the aluminium content of infant formulas it must now be time for the government, through the Food Standards Agency, to provide guidance on this matter and to indicate a maximum allowable concentration, for example, 50 ppb (50 mg/L) aluminium in the product at point of use, as a precautionary step to protect infants against chronic aluminium intoxication during the earliest weeks, months and years of their lives." | It is the opinion of the authors that regulatory and other nonvoluntary methods are now required to reduce the aluminium content of infant formulas and thereby protect infants from chronic exposure to dietary aluminium. | Professor Exley said: "Clearly the manufacturers of infant formulas are not concerned about reducing their content of aluminium and the extensive use of aluminium-based packaging for infant formulas seems to confirm this. "There are no adequate criteria upon which to base a safety level for aluminium in infant formulas and for this reason it would be sensible to take action to reduce the level of aluminium to a lowest practicable level. "Since manufacturers are not willing to address the aluminium content of infant formulas it must now be time for the government, through the Food Standards Agency, to provide guidance on this matter and to indicate a maximum allowable concentration, for example, 50 ppb (50 mg/L) aluminium in the product at point of use, as a precautionary step to protect infants against chronic aluminium intoxication during the earliest weeks, months and years of their lives." | There was no clear evidence that subsequent to the problem of aluminium being highlighted in a previous publication in this journal that contamination had been addressed and reduced. It is the opinion of the authors that regulatory and other nonvoluntary methods are now required to reduce the aluminium content of infant formulas and thereby protect infants from chronic exposure to dietary aluminium. However, the range of values obtained was skewed towards high content and we were left to conclude that the aluminium content of infant formulas were too high, for example as compared to aluminium exposure through breast milk . | [4.0, 4.0, 4.0, 4.0, 3.0] | Medicine | train | 3.8 | news | http://www.healthcanal.com/child-health/43790-action-needed-now-to-lower-the-content-of-aluminium-in-infant-formulas.html |
10.1111/jgs.15671 | Medicine_72 | The nurse practice environment was the best predictor of poor-quality end-of-life care. | The best predictor of poor quality was the nurse practice environment. | The researchers found that 58 percent of nurses gave their hospitals an unfavorable evaluation of end-of-life care overall and 53 percent reported that patients often experience painful procedures that were unlikely to change their outcome. The nurse practice environment was the best predictor of poor-quality end-of-life care. Compared to nurses in poor-quality environments, nurses in the best environments were less likely to rate their hospital's overall end-of-life care quality unfavorably (odds ratio, 0.45). | The best predictor of poor quality was the nurse practice environment. Nurses in the best environments were 55% less likely than nurses in poor environments to rate their hospital's overall end-oflife care quality unfavorably (odds ratio = 0.45; 95% confidence interval = 0.39-0.52; P < .001). CONCLUSION: Quality of end-of-life care in US hospitals is imperfect and is significantly worse in hospitals with poor nurse practice environments than in hospitals with the best environments. | [5.0, 4.0, 5.0] | Medicine | train | 4.666667 | news | http://ct.moreover.com/?a=38083013721&p=1pl&v=1&x=ehR_OuxwwqRLFfruA-gOJQ |
10.1001/jama.2018.20578 | Medicine_73 | No effect was seen with aspirin on new cancer diagnoses or deaths. | In this meta-analysis, the use of aspirin in individuals without cardiovascular disease was associated with a lower risk of cardiovascular events and an increased risk of major bleeding. | Aspirin use was associated with a 43% of major bleeding events, compared to those who did not take it. No effect was seen with aspirin on new cancer diagnoses or deaths. Lead author, Dr Sean Zheng, Academic Clinical Fellow in Cardiology at King's College London said: "This study demonstrates that there is insufficient evidence to recommend routine aspirin use in the prevention of heart attacks, strokes and cardiovascular deaths in people without cardiovascular disease. | 19, 22 Increasing adoption of additional primary prevention strategies, such as risk factor modification and development of public health initiatives, may limit the applicability of earlier studies to current practice. In this meta-analysis, the use of aspirin in individuals without cardiovascular disease was associated with a lower risk of cardiovascular events and an increased risk of major bleeding. This information may inform discussions with patients about aspirin for primary prevention of cardiovascular events and bleeding. | [2.0, 2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.4 | news | https://www.sciencedaily.com/releases/2019/01/190122114950.htm |
10.1001/jamapsychiatry.2018.1941 | Medicine_74 | From the other side, people with insomnia also have a higher risk of depression and anxiety. | Further, the mediating effects of the 39 functional connectivities of the effects of the sleep quality on the depressive problems had much lower significance (3.4% of the total effect size, =0.016, p=0.0095, Fig. | "These findings provide a neural basis for understanding how depression relates to poor sleep quality, and this in turn has implications for treatment of depression and improvement of sleep quality because of the brain areas identified." From the other side, people with insomnia also have a higher risk of depression and anxiety. While this particular study found strong neural connections in the association of depressive problems with poor sleep quality, rather than the other way around, in general the effects can work both ways. | In the reverse direction, only 2 links significantly mediated effects of sleep quality on depressive problems with FDR correction. Further, the mediating effects of the 39 functional connectivities of the effects of the sleep quality on the depressive problems had much lower significance (3.4% of the total effect size, =0.016, p=0.0095, Fig. S4 ) than for the effect in the opposite direction described above. | [2.0, 3.0, 1.0, 1.0, 3.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=34644678837&p=1pl&v=1&x=NPMHP58RsDT7VzhGCx19YA |
10.1177/0141076814565942 | Medicine_75 | The researchers also made the observation of an increased risk of hyperactivity disorder among circumcised boys in non-Muslim families. | However, risk was significantly increased among circumcised boys in non-Muslim families (HR ¼ 1.81; 95% CI: 1.11-2.96), and risk appeared to be particularly high in the <5 years age window (HR ¼ 3.60; 95% CI: 1.16-11.18), although the latter observation was based on only three cases. | They found that regardless of cultural background circumcised boys may run a greater risk of developing ASD. The researchers also made the observation of an increased risk of hyperactivity disorder among circumcised boys in non-Muslim families. Risk was particularly high for infantile autism before the age of five, at least in epidemiology. | Among boys in Muslim families, risk of hyperkinetic disorder did not depend on the boys' foreskin status (HR ¼ 1.08; 95% CI: 0.77-1.52). However, risk was significantly increased among circumcised boys in non-Muslim families (HR ¼ 1.81; 95% CI: 1.11-2.96), and risk appeared to be particularly high in the <5 years age window (HR ¼ 3.60; 95% CI: 1.16-11.18), although the latter observation was based on only three cases. Associations of ritual circumcision with risk of asthma were consistently negative, both in the 0-4 years (HR ¼ 0.91; 95% CI: 0.78-1.06) and the 5-9 years age interval (HR ¼ 1.16; 95% CI: 0.89-1.51), yielding an inconspicuous overall HR estimate (HR ¼ 0.96; 95% CI: 0.84-1.10) based on a total of 235 cases of asthma in circumcised boys versus 29,002 cases in intact boys. | [2.0, 4.0, 5.0] | Medicine | train | 5 | news | http://www.science20.com/news_articles/circumcision_linked_to_autism_study-152121 |
10.1038/s41467-018-04408-0 | Medicine_76 | If you eliminate testosterone, you get more BAFF and thereby more B cells in the spleen because they survive to a greater extent. | In the present study, we found that serum BAFF levels were higher in female compared to male mice, which is in accordance with a previous report of sex differences in BAFF levels among wild-type controls . | After numerous experiments on mice and studies of blood samples from 128 men, the researchers were able to conclude that the critical connection is the protein BAFF, which makes the B cells more viable. If you eliminate testosterone, you get more BAFF and thereby more B cells in the spleen because they survive to a greater extent. Recognition of the link between testosterone and BAFF is completely new. | Interestingly, both hormones suppress bone marrow B lymphopoiesis but differ in their effects on splenic B cell number and BAFF. In the present study, we found that serum BAFF levels were higher in female compared to male mice, which is in accordance with a previous report of sex differences in BAFF levels among wild-type controls . We further found that testosterone suppresses BAFF, and others have shown that estradiol increases Baff mRNA levels and the relative number of mature B cells in the spleen . | [2.0, 3.0, 3.0, 2.0, 1.0] | Medicine | train | 2.2 | news | http://ct.moreover.com/?a=34228585539&p=1pl&v=1&x=jeRWiJSUImhYEA135bTOfw |
10.1152/ajpregu.00204.2013 | Medicine_77 | Importance of the Findings The study, according to Dr. Smith, confirms for the first time in vivo that CO has a beneficial effect at the placental level. | This adaptive angiogenesis was similar to our findings. | Compared to controls, CO exposure did lead to increased vessel diameter, a significant increase in the number of radial artery branches, and significantly higher maternal blood flow. Importance of the Findings The study, according to Dr. Smith, confirms for the first time in vivo that CO has a beneficial effect at the placental level. It also provides an explanation for the lower incidence of PE among smokers, whose CO levels are higher. | The placentas of women who smoke in pregnancy have been reported as larger in size, with an increase in branching of the vascular tree ; the authors suggest that this alteration is an adaptation response, increasing surface area for nutrient transfer. This adaptive angiogenesis was similar to our findings. It is clear that CO plays a role in angiogenesis, a process necessary for placentation and may account for the COinduced increases of placental vessel branching in the placentas of women who smoke in pregnancy. | [1.0, 2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.2 | news | http://www.sciencedaily.com/releases/2013/09/130919154253.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1016/j.ejca.2017.11.022 | Medicine_78 | The correlation between eating chicken and a lower risk of breast cancer may have more to do with consuming large quantities of red meat than it does with chicken having any protective qualities. | Of the eleven cohort studies, ten reported the association between red meat consumption and overall risk of breast cancer; of these, six also reported results separately for pre-menopausal and post-menopausal breast cancer. | As with all observational studies, this research cannot show cause and effect. The correlation between eating chicken and a lower risk of breast cancer may have more to do with consuming large quantities of red meat than it does with chicken having any protective qualities. Some 1,536 cases of invasive breast cancer were diagnosed among the cohort over the eight-year period. | A further five studies were excluded due to repeat analyses conducted on the same cohort and two due to inadequate exposure information; resulting in ten eligible cohort studies in addition to UK Biobank ( Figure 1) . Of the eleven cohort studies, ten reported the association between red meat consumption and overall risk of breast cancer; of these, six also reported results separately for pre-menopausal and post-menopausal breast cancer. The ten studies produced a pooled relative risk for breast cancer, overall, of 1.03 (95% CI 0.99-1.08) (Figure 2 ). | [3.0, 4.0, 3.0, 2.0, 2.0] | Medicine | train | 2.8 | news | http://ct.moreover.com/?a=40018041593&p=1pl&v=1&x=0-S1_nh44txdcV7SbNzZRw |
10.1001/jamapediatrics.2018.0302 | Medicine_79 | Taking vitamin D during pregnancy was safe, with no extra fetal or neonatal mortality, congenital abnormality, or critical illness at birth, said senior author Dr. Shu Qin Wei of the University of Montreal, Canada. | Vitamin D supplementation with doses of 2000 IU/d or lower during pregnancy may reduce the risk of fetal or neonatal mortality. | At higher doses, any differences between women who took vitamin D and those who didn't were too small to rule out the possibility that they were due to chance. Taking vitamin D during pregnancy was safe, with no extra fetal or neonatal mortality, congenital abnormality, or critical illness at birth, said senior author Dr. Shu Qin Wei of the University of Montreal, Canada. And supplementation reduced infants' risk of being small for gestational age and improved their calcium levels and growth in the first 12 months of life. | CONCLUSIONS AND RELEVANCE Vitamin D supplementation during pregnancy is associated with a reduced risk of SGA and improved infant growth without risk of fetal or neonatal mortality or congenital abnormality. Vitamin D supplementation with doses of 2000 IU/d or lower during pregnancy may reduce the risk of fetal or neonatal mortality. Low vitamin D level status during pregnancy may expose the offspring to a suboptimal nutritional environment during critical phases of fetal development and may have long-term effects on offspring health outcomes. | [2.0, 2.0, 2.0, 5.0, 4.0] | Medicine | train | 4 | news | http://ct.moreover.com/?a=34180824606&p=1pl&v=1&x=LymT53igqmp5seujNS7GFA |
10.1001/jama.2013.277165 | Medicine_8 | Otamixaban consistently increased all types of bleeding events, regardless of the severity or bleeding classification scheme used. | Otamixaban consistently increased all types of bleeding events, regardless of the severity or bleeding classification scheme used (Table 2 ; and eTable 4 in the Supplement), and without interaction across patient subsets, including demographics, previous treatment, risk scores, biomarkers or management (eFigure 3B and eFigure 4 in the Supplement). | Patients in the otamixaban group had about double the rate of the primary safety outcome of Thrombosis in Myocardial Infarction major or minor bleeding at day 7 compared with patients in the combination of UFH-plus-eptifibatide group (3.1 percent vs. 1.5 percent). Otamixaban consistently increased all types of bleeding events, regardless of the severity or bleeding classification scheme used. Study anticoagulant was discontinued because of bleeding in 242 patients (4.7 percent) in the otamixaban group and in 95 patients (1.7 percent) in the UFH-plus-eptifibatide group. | Patients in the otamixaban group had an increased rate of the primary safety outcome of TIMI major or minor bleeding at day 7 compared with patients in the combination of UFHplus-eptifibatide group (3.1% vs 1.5%; RR, 2.13 [95% CI, 1.63-2.78]; P < .001; Table 2 ). Otamixaban consistently increased all types of bleeding events, regardless of the severity or bleeding classification scheme used (Table 2 ; and eTable 4 in the Supplement), and without interaction across patient subsets, including demographics, previous treatment, risk scores, biomarkers or management (eFigure 3B and eFigure 4 in the Supplement). Study anticoagulant was discontinued because of bleeding in 242 patients (4.7%) in the otamixaban group and in 95 patients (1.7%) in the UFH-pluseptifibatide group (P < .001). | [4.0, 4.0, 5.0, 5.0, 4.0] | Medicine | train | 4.4 | news | http://www.sciencedaily.com/releases/2013/09/130901153354.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1002/emmm.201302567 | Medicine_80 | "We observed delayed onset of motor neuron dysfunction; we noted also that SMN2 mis-splicing increases during the late stages of SMA, likely accelerating its progression in the body. | SMN2 mis-splicing increased during late-stage disease. | "Our efforts to model the adult form of SMA were successful," says Kentaro Sahashi, M.D., Ph.D., a postdoctoral researcher and neurologist who is first author of the team's new paper. "We observed delayed onset of motor neuron dysfunction; we noted also that SMN2 mis-splicing increases during the late stages of SMA, likely accelerating its progression in the body. We noted, importantly, marked liver and heart pathologies that were related to SMA's progression in adults." | Systemic ASO injection elicited marked liver and heart pathologies, and resulted in decreased levels of circulating IGF1. SMN2 mis-splicing increased during late-stage disease. Our study also suggests that high SMN levels are not as critical in adults, and there is a broad therapeutic time window for treatment of adult-onset SMA. | [5.0, 5.0, 2.0, 4.0] | Medicine | train | 4 | news | http://www.sciencedaily.com/releases/2013/09/130909093116.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1038/s41598-018-29793-w | Medicine_82 | Well, as a turns out, your nose has a microbiome, too a and it might play a key role in how well you fight off colds. | The nasal microbiota clusters of subjects before the infection associated with the severity of clinical cold symptoms during rhinovirus infection. | Well, as a turns out, your nose has a microbiome, too a and it might play a key role in how well you fight off colds. As if that werenat weird enough, researchers further found that study participantsa noses fell into six different nasal microbiome subtypes. These nasal microbiome types are linked to how bad your cold symptoms get, and how well you fight the virus off in the first place. | The clusters predominant of Staphylococcus, Corynebacterium/Alloiococcus, Moraxella, and Pseudomonadaceae/Mixed had characteristic inflammatory marker and viral load profiles in nasal washes. The nasal microbiota clusters of subjects before the infection associated with the severity of clinical cold symptoms during rhinovirus infection. Rhinovirus infection and probiotic intervention did not significantly alter the composition of nasal or fecal microbiota. | [1.0, 4.0, 5.0, 3.0] | Medicine | train | 4 | news | http://ct.moreover.com/?a=37227743738&p=1pl&v=1&x=2zyW9bON3VHP6zbXr8qTXQ |
10.1098/rsos.171474 | Medicine_83 | "We found a whole lot of nothing," Przybylski said. | Despite the null findings identified in the present study, history gives us reason to suspect the idea that violent video games drives aggressive behaviour will remain an unsettled question for parents, pundits and policy-makers. | "We found a whole lot of nothing," Przybylski said. "Basically, we found that having information about the kinds of video games people played, how violent they were, how much time they spent on them, there was no linear connection." "We found pretty conclusive evidence that, among at least British teens, there is no connection between violent video game play and violent aggression," he said. | Until such findings are confirmed, however, we strongly would caution about drawing impulsive, thoughtless or potentially stigmatizing conclusions about members of such groups . Despite the null findings identified in the present study, history gives us reason to suspect the idea that violent video games drives aggressive behaviour will remain an unsettled question for parents, pundits and policy-makers. Although our results do have implications for these stakeholders, the present work holds special significance for those studying technology effects, in general, and video games, in particular. | [2.0, 5.0, 1.0, 2.0, 4.0] | Medicine | train | 3 | news | http://ct.moreover.com/?a=39875701073&p=1pl&v=1&x=dQGeE7OWTZ_rTEJvCuEV5g |
10.1016/j.stemcr.2018.03.019 | Medicine_84 | X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs. | We conclude that global DNA hypomethylation correlates with the presence of two active X chromosomes during reprogramming to iPSCs. | Note: material may have been edited for length and content. For further information, please contact the cited source. X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs. | Thus, iPSCs display the same strong relationship between the presence of two active X chromosomes and global hypomethylation as female mouse ESCs . We conclude that global DNA hypomethylation correlates with the presence of two active X chromosomes during reprogramming to iPSCs. In Addition to the Non-repetitive Genome, Hypomethylation in Female iPSCs Affects the Repetitive Genome as well as ICRs One characteristic of the female XaXa ESC genome is hypomethylation of repetitive elements . | [4.0, 3.0, 4.0, 2.0] | Medicine | train | 3.25 | news | http://ct.moreover.com/?a=33847856937&p=1pl&v=1&x=vV_Dne2GAjTKIkp14dSTOw |
10.14814/phy2.13617 | Medicine_85 | The study, published today in the journal Physiological Reports, is the first to assess the hormonal impact nighttime light exposure can have on young children. | Specifically, electronic device use before bedtime suppressed melatonin, delayed the timing of melatonin onset, increased sleep onset latency by 10-min, and negatively affected next day alertness. | The study, published today in the journal Physiological Reports, is the first to assess the hormonal impact nighttime light exposure can have on young children. The study comes at a time when use of electronics is rapidly expanding among this age group and adds to a growing body of evidence suggesting that-because of structural differences in their eyes-children may be more vulnerable to the impact light has on sleep and the body clock. "In this study we found that these kids were extremely sensitive to light." | Thus, the 1-h before bedtime may represent a window during which the circadian system is sensitive to perturbations (i.e., suppression of melatonin and phase delays) . Specifically, electronic device use before bedtime suppressed melatonin, delayed the timing of melatonin onset, increased sleep onset latency by 10-min, and negatively affected next day alertness. Considering that the screens of most electronic devices peak in the short wavelengths and lens transparency differences across age are most prominent at shorter wavelengths , we expect that young children are more sensitive to the effects of light emitted from these sources. | [4.0, 3.0, 3.0, 1.0] | Medicine | train | 2.75 | news | http://healthmedicinet.com/news/preschoolers-exposed-to-nighttime-light-lack-melatonin/ |
10.1016/j.cell.2018.04.034 | Medicine_86 | The fact that immune checkpoint inhibitors may be effective against this sub-type of prostate cancer makes it even more significant. | Further, we identify that CDK12 mutant tumors have synthetic genetic dependencies and a characteristic immunophenotype, which provide candidate targets for precision therapy. | "Because prostate cancer is so common, 7 percent is a significant number. The fact that immune checkpoint inhibitors may be effective against this sub-type of prostate cancer makes it even more significant. This is an exciting prospect for patients who have CDK12 alterations and may benefit from immunotherapy," says senior study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology. | We show that CDK12 mutants are genetically, transcriptionally, and phenotypically distinct from HRD and MMRD tumors. Further, we identify that CDK12 mutant tumors have synthetic genetic dependencies and a characteristic immunophenotype, which provide candidate targets for precision therapy. We detected aberrations of CDK12 in 25/360 of mCRPC patients (6.9%), 95% confidence interval (CI) [4.6%, 10 .2%] ( Figure 1A ). | [4.0, 4.0, 2.0, 4.0, 1.0] | Medicine | train | 4 | news | http://ct.moreover.com/?a=34304617241&p=1pl&v=1&x=JkbWFHiGsGoeqOJxN0A0-A |
10.1177/0956797617692041 | Medicine_87 | But data from two additional experiments indicate that this unintended increase in consumption can be dampened somewhat by requiring people to get the refills themselves. | Experiment 3a suggests that requiring participants to get their own refills alleviates the perverse effect of the free-refill response to a portion cap. | This may have happened, the researchers surmise, because consumers wanted to get their "money's worth" - that is, they consumed more of the refill since they had already paid for it. But data from two additional experiments indicate that this unintended increase in consumption can be dampened somewhat by requiring people to get the refills themselves. "Taken together, these results suggest that this method of complying with a sugary-drink portion limit could have the perverse effect of increasing consumption," the researchers write. | However, at least in this instance, it did not achieve the intended purpose of reducing consumption. Experiment 3a suggests that requiring participants to get their own refills alleviates the perverse effect of the free-refill response to a portion cap. Of 285 participants, 48.4% were male and 50.5% were female; 1.1% did not report their gender. | [4.0, 2.0, 4.0, 4.0] | Medicine | train | 3.5 | news | http://healthmedicinet.com/news/some-strategies-to-limit-sugary-drinks-may-backfire/ |
10.1210/jc.2013-2350 | Medicine_88 | In the CPG, The Endocrine Society recommends that a diagnosis be made if adult women have two of the three cardinal features of PCOS (diagnostic criteria supported by the NIH panel):* Excess production of male hormones called androgens. | Evaluation of women with PCOS should exclude alternate androgen-excess disorders and risk factors for endometrial cancer, mood disorders, obstructive sleep apnea, diabetes, and cardiovascular disease. | "The Society's recommendations allow physicians to make the diagnosis if clear symptoms are present without resorting to universal hormone tests or ultrasound screening." In the CPG, The Endocrine Society recommends that a diagnosis be made if adult women have two of the three cardinal features of PCOS (diagnostic criteria supported by the NIH panel):* Excess production of male hormones called androgens. Other recommendations from the CPG include:
* Because women with PCOS face an increased risk of pregnancy complications such as gestational diabetes, preterm delivery and preeclampsia that can be exacerbated by obesity, women should have their body mass index, blood pressure and oral glucose tolerance assessed prior to conceiving;
* Following diagnosis, women with PCOS should be examined for skin and hair complications including excess hair growth and acne;
* Although women with PCOS have some of the same risk factors associated with the development of endometrial cancer, they should not routinely undergo ultrasound screening for endometrial thickness;
* To gauge metabolic risk, adolescents and adult women with PCOS should be screened for increased obesity using body mass index and waist circumference measurements;
* Clinicians should give adolescents and adult women with PCOS an oral glucose tolerance test to check for type 2 diabetes or impaired glucose tolerance because they are at increased risk of these conditions; and
* Initial treatment of type 2 diabetes or impaired glucose tolerance in women with PCOS should be diet and exercise, with metformin as a second-line therapy. | We suggest using the Rotterdam criteria for diagnosing PCOS (presence of two of the following criteria: androgen excess, ovulatory dysfunction, or polycystic ovaries). Evaluation of women with PCOS should exclude alternate androgen-excess disorders and risk factors for endometrial cancer, mood disorders, obstructive sleep apnea, diabetes, and cardiovascular disease. Thiazolidinediones have an unfavorable riskbenefit ratio overall, and statins require further study. | [1.0, 2.0, 3.0, 2.0, 1.0] | Medicine | train | 1.8 | news | http://www.newswise.com/articles/experts-clarify-conflicting-criteria-for-diagnosing-polycystic-ovary-syndrome |
10.1073/pnas.1504869112 | Medicine_89 | Extrapolating their results to tropical forests as a whole, the team calculated that lianas could potentially reduce long-term storage of carbon in tropical forests by one-third or more. | While the strength of the liana effect will vary with the density and biomass of lianas, the increase in liana density, biomass, and productivity reported in many neotropical forests (9, 10, 23) may be partially responsible for the longterm decline in the Amazonian carbon sink , which in turn contributes to increasing atmospheric carbon dioxide levels and accelerated climate change. | The researchers found that study plots with lianas accumulated 76 percent less biomass over the experimental period due to reduced tree growth and increased tree death. Extrapolating their results to tropical forests as a whole, the team calculated that lianas could potentially reduce long-term storage of carbon in tropical forests by one-third or more. The study will be useful in guiding scientists working to predict the trajectory of carbon storage as atmospheric concentrations rise, and it may help explain recent observations that the carbon storage capacity of tropical forests is declining. | Notwithstanding, our results indicate that, due to their unique attributes, lianas have the potential to severely reduce both the carbon sink potential and long-term carbon storage capacity of tropical forests. While the strength of the liana effect will vary with the density and biomass of lianas, the increase in liana density, biomass, and productivity reported in many neotropical forests (9, 10, 23) may be partially responsible for the longterm decline in the Amazonian carbon sink , which in turn contributes to increasing atmospheric carbon dioxide levels and accelerated climate change. Aboveground tree carbon stocks in these 16 plots averaged 75.1 Mg C ha -1 , which was representative for other ∼60 year old forests in the neotropics . | [2.0, 3.0, 3.0, 2.0, 4.0] | Medicine | train | 2.8 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/PUyOGba13Ho/ |
10.1038/s41467-018-08278-4 | Medicine_9 | The results of the study showed that the regeneration process was most advanced when BMP2 was applied first, with BMP9 added a week after - in this case it led to the growth of more complete joint structures, even with some connections to the bone. | Control studies in which BMP2 treatment was followed by a second treatment with another BMP2 bead stimulated excessive bone growth but not the regeneration of joint structures ( Fig. | "These studies provide evidence that treatment of growth factors can be used to engineer a regeneration response from a non-regenerating amputation wound," explain the researchers in their paper. The results of the study showed that the regeneration process was most advanced when BMP2 was applied first, with BMP9 added a week after - in this case it led to the growth of more complete joint structures, even with some connections to the bone. Humans are similar to mice in terms of the way our skeletons fit together, so this is possibly something that could be transferred over. | In both series, histological analyses indicated the regeneration of a complete joint structure that included a layer of articular cartilage lining the stump (Fig. Control studies in which BMP2 treatment was followed by a second treatment with another BMP2 bead stimulated excessive bone growth but not the regeneration of joint structures ( Fig. d; 0/16 digits) . | [3.0, 3.0, 3.0, 3.0, 3.0] | Medicine | train | 3 | news | http://ct.moreover.com/?a=38466420113&p=1pl&v=1&x=IqxylWeo6-sJ6dtu0xtBJQ |
10.1073/pnas.1719801115 | Medicine_90 | The researchers suggest that the active form of MinE briefly remains in the open conformation and can therefore "jump on" the nearest membrane-bound MinD. | Upon detachment from the membrane, MinE quickly reassumes its latent conformation with its MinD-and membrane-interaction regions buried (Fig. | Once in this state, MinE activates MinD's ATPase function, and both MinE and MinD-ADP are released from the membrane. The researchers suggest that the active form of MinE briefly remains in the open conformation and can therefore "jump on" the nearest membrane-bound MinD. "This ability to switch between the two conformations is essential for the robustness of pattern formation, and allows pattern formation even for strongly enhanced MinE concentrations, as our simulations have shown," says Frey. | In addition, after dissociation of the MinDE complex and the release of MinD-ADP into the cytosol, MinE's MTS enables it to remain bound to the membrane, and the protein may reassociate repeatedly with other membrane-bound MinD molecules or (eventually) return to the cytosol . Upon detachment from the membrane, MinE quickly reassumes its latent conformation with its MinD-and membrane-interaction regions buried (Fig. In contrast, in silico and in vitro approaches both allow highly comparable conditions and the precise variation of parameters. | [4.0, 3.0, 3.0, 4.0, 2.0] | Medicine | train | 3.2 | news | http://ct.moreover.com/?a=33823920795&p=1pl&v=1&x=YBjBpHcja7cILepug4S5RQ |
10.1001/jama.2018.20578 | Medicine_94 | They found that while it was associated with a lower risk of heart attacks and other cardiovascular events, it did lead to an increased risk of major bleeding. | The current study demonstrates that the absolute risk reduction for cardiovascular events and absolute risk increase for major bleeding associated with aspirin use were of similar magnitude. | They found that while it was associated with a lower risk of heart attacks and other cardiovascular events, it did lead to an increased risk of major bleeding. The results showed that:
Aspirin use was associated with an 11% lower risk of cardiovascular events. Approximately 250 patients needed to be treated with aspirin for 5 years to prevent a single heart attack, stroke or cardiovascular death. | 6 This study showed that when analysis was restricted to populations with observation-derived 10-year cardiovascular event rate estimates of 10% or more, aspirin use was associated with an absolute risk decrease of 0.51% (5% CI, 0.06%-0.3%) for the cardiovascular composite outcome, but an absolute risk increase of 0.64% (5% CI, 0.35%-0.7%) for major bleeding. The current study demonstrates that the absolute risk reduction for cardiovascular events and absolute risk increase for major bleeding associated with aspirin use were of similar magnitude. Aspirin use was not associated with a reduction in cardiovascular mortality, and deaths due to bleeding were rare. | [5.0, 4.0, 1.0, 5.0] | Medicine | train | 4 | news | https://www.sciencedaily.com/releases/2019/01/190122114950.htm |
10.1186/s40168-015-0071-z | Medicine_95 | The researchers emphasized that the finding does not suggest that breast milk from mothers without an active copy of the gene is less nourishing or healthy. | In aggregate, the bifidobacterial species distribution did not differ greatly between secretor-fed infants and non-secretor-fed infants. | The research may have applications in a clinical setting for protecting premature infants from a range of intestinal diseases including necrotizing enterocolitis (NEC), a condition that is the second most common cause of death among premature infants in the United States. The researchers emphasized that the finding does not suggest that breast milk from mothers without an active copy of the gene is less nourishing or healthy. Rather, it conveys the subtle and elegant choreography of one part of the human microbiome: The relationships between the mothers' genetics, the composition of her breast milk and the development of thier infants' gut microbiota. | However, it may be that only some bifidobacterial species would possess this advantage, due to differences in abilities of various species to consume fucosylated substrates. In aggregate, the bifidobacterial species distribution did not differ greatly between secretor-fed infants and non-secretor-fed infants. As the species of bifidobacteria present within an infant are dependent on environmental exposure, we tentatively conclude that this subset of geographically co-located infants was exposed to similar sets of bifidobacterial species. | [5.0, 2.0, 3.0, 4.0] | Medicine | train | 3.5 | news | http://www.healthcanal.com/genetics-birth-defects/62224-a-mother-s-genes-can-influence-the-bacteria-in-her-baby-s-gut-researchers-at-uc-davis-have-found.html |
10.1038/s41598-017-18618-x | Medicine_96 | In addition, plasma triglycerides and total cholesterol levels were decreased and HDL (good lipids) was increased in the ACV group. | ACV decreased the serum lipid profile in mice fed a high cholesterol diet over days. | This study administered 30 cc of ACV per day and found that it created significantly reduced body weight, BMI, hip-circumference, visceral adiposity index, and appetite score. In addition, plasma triglycerides and total cholesterol levels were decreased and HDL (good lipids) was increased in the ACV group. Weight checks are done at six and twelve-week intervals showed a significant reduction in BMI and body fat in this ACV group (Khezri et al, 2018). | Another means of action could involve the acetic acid component of ACV which is able to reduce the cell hydrogen potential hence could potentially facilitate diffusion across the plasma membrane of microbes. ACV decreased the serum lipid profile in mice fed a high cholesterol diet over days. Intragastric ACV addition induced a protective effect against erythrocyte, kidney and liver oxidative injury as well as lowering cholesterol levels . | [4.0, 1.0, 3.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=39098464353&p=1pl&v=1&x=1oF0R8OHMp2RCFFanDJNtw |
10.1016/j.cell.2018.04.034 | Medicine_97 | "It suggests that those early stage patients who have CDK12 loss are the ones who will develop metastatic disease. | The majority of CDK12 mutations (83%) were truncating and resulted in the loss of the kinase domain. | That jumped to 7 percent for metastatic cancer, which indicates a more-aggressive form of the disease. "It suggests that those early stage patients who have CDK12 loss are the ones who will develop metastatic disease. This could be a harbinger in early cancer," Chinnaiyan says. | CRPC genomes are more highly mutated than those of localized tumors; however, the magnitude of the increased mutation rate is not sufficient to explain the increased frequency of biallelic loss of CDK12. The majority of CDK12 mutations (83%) were truncating and resulted in the loss of the kinase domain. Missense mutations were clustered around conserved residues in the kinase domain ( Figure S1 ). | [2.0, 3.0, 1.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=34304617241&p=1pl&v=1&x=JkbWFHiGsGoeqOJxN0A0-A |
10.1007/s13524-014-0321-x | Medicine_99 | "Those who become parents at young ages have a downward happiness trajectory, but those who become parents at older ages and men with more resources have more positive short- and long-term responses to a birth," the scientists claim. | Our study has limitations. | In addition, the data reveals that a reaction to a birth is highly influenced by such sociodemographic characteristics as age or socioeconomic status. "Those who become parents at young ages have a downward happiness trajectory, but those who become parents at older ages and men with more resources have more positive short- and long-term responses to a birth," the scientists claim. This fact can also in part explain why mean age of parents has increased. | Future research could consider whether this has changed the well-being implications of having children. Our study has limitations. First, although our fixed-effects approach is robust to attrition that varies only across individuals but not within, time-varying attrition risk that is correlated with childbearing could influence our results. | [1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://www.technology.org/2014/08/27/third-child-make-parents-happier/ |
10.1001/jama.2018.20578 | Medicine_tweet_0 | This meta-analysis confirms that use of #aspirin for primary prevention of #cardiovasculardisease is associated with a lower risk of CV events including CV mortality and nonfatal AMI and #stroke, and an increased risk of major bleeding. | Aspirin use was associated with significant reductions in the composite cardiovascular outcome compared with no aspirin (57.1 per 10 000 participant-years with aspirin and 61.4 per 10 000 participant-years with no aspirin) (hazard ratio CONCLUSIONS AND RELEVANCE The use of aspirin in individuals without cardiovascular disease was associated with a lower risk of cardiovascular events and an increased risk of major bleeding. | This meta-analysis confirms that use of #aspirin for primary prevention of #cardiovasculardisease is associated with a lower risk of CV events including CV mortality and nonfatal AMI and #stroke, and an increased risk of major bleeding. | The median age of trial participants was 62 years (range, 53-74), 77 501 (47%) were men, 30 361 (19%) had diabetes, and the median baseline risk of the primary cardiovascular outcome was 9.2% (range, 2.6%-15.9%). Aspirin use was associated with significant reductions in the composite cardiovascular outcome compared with no aspirin (57.1 per 10 000 participant-years with aspirin and 61.4 per 10 000 participant-years with no aspirin) (hazard ratio CONCLUSIONS AND RELEVANCE The use of aspirin in individuals without cardiovascular disease was associated with a lower risk of cardiovascular events and an increased risk of major bleeding. This information may inform discussions with patients about aspirin for primary prevention of cardiovascular events and bleeding. | [5.0, 5.0, 5.0, 5.0] | Medicine | train | 5 | tweets | 1087877579288297472 |
10.1001/jamaophthalmol.2017.4816 | Medicine_tweet_1 | Trainees in clinic associated w longer appointment times, even for patients not seen by a trainee. | The presence of a trainee in a clinic session was associated with longer mean appointment times, even in appointments in which the trainee was not present. | Trainees in clinic associated w longer appointment times, even for patients not seen by a trainee. | Findings In this single-center cohort study of 49 448 outpatient ophthalmology appointments by 33 attending physicians, appointments with residents and fellows were 32% and 30% longer, respectively, than appointments without trainees. The presence of a trainee in a clinic session was associated with longer mean appointment times, even in appointments in which the trainee was not present. Meaning Academic medical centers face potential challenges in maintaining clinical efficiency and medical education, particularly in emerging value-based reimbursement models. | [5.0, 5.0, 5.0, 5.0] | Medicine | train | 5 | tweets | 928668516101902337 |
10.1001/jamaneurol.2017.4618 | Medicine_tweet_10 | Acute lesions on diffusion #MRI of the brain could predict delayed neurological sequelae following acute CO poisoning. | Multivariable logistic regression analysis indicated that the presence of acute brain lesions was independently associated with development of delayed neurological sequelae (adjusted odds ratio, 13.93; 95% CI, 7.16-27.11; P < .001). | Acute lesions on diffusion #MRI of the brain could predict delayed neurological sequelae following acute CO poisoning. | Multivariable logistic regression analysis indicated that the presence of acute brain lesions was independently associated with development of delayed neurological sequelae (adjusted odds ratio, 13.93; 95% CI, 7.16-27.11; P < .001). The sensitivity and specificity of acute brain lesions to assess the probability of delayed neurological sequelae were 75.2% (95% CI, 66.8%-83.7%) and 90.2% (95% CI, 86.8%-93.7%), respectively. In addition, the positive and negative predictive values were 73.1% (95% CI, 64.6%-81.6%) and 91.2% (95% CI, 87.9%-94.5%), respectively. | [2.0, 4.0, 3.0, 5.0, 4.0] | Medicine | train | 3.6 | tweets | 958021925342760960 |
10.1111/infa.12017 | Medicine_tweet_100 | Ha- I guess once we start talking we forget to consider how other people feel: Infants Match Emotional Expressions | The present findings are the first to show 5-month-olds match the faces and voices of other infants on the basis of global invariant properties common to facial and vocal emotional expressions. | Ha- I guess once we start talking we forget to consider how other people feel: Infants Match Emotional Expressions | These temporal and intensity patterns are invariant across face and voice and may specify different emotional valences which can be detected only in dynamic, moving expressions ) where changes in intensity and temporal patterns are evident. The present findings are the first to show 5-month-olds match the faces and voices of other infants on the basis of global invariant properties common to facial and vocal emotional expressions. Infants' intermodal matching of facial and vocal affective information in unfamiliar peers appears to emerge somewhat earlier (by 5 months but not 3.5 months of age) than their matching of facial and vocal affective information in unfamiliar adults (by 7 months but not 5 months of age; ) . | [4.0, 3.0, 1.0, 2.0, 4.0] | Medicine | train | 2.8 | tweets | 350351449005371392 |
10.1016/j.cub.2013.11.012 | Medicine_tweet_101 | We show that generalization is different in subjects who never used a computer: science news: | Interestingly, non-computer users still have a broad generalization as their generalization is significantly larger than zero even at the largest angular separation of 180 (30.0% 6 6.9%; p < 0.001, one-sample t test). | We show that generalization is different in subjects who never used a computer: science news: | However, the computer users, compared to the non-computer-user group, generalize much more into other directions [interaction effect F(8, 96) = 6.9, p < 0.0001; main effect on groups F(2, 24) = 12.5, p < 0.0001, two-way ANOVA; Figure 2B ]. Interestingly, non-computer users still have a broad generalization as their generalization is significantly larger than zero even at the largest angular separation of 180 (30.0% 6 6.9%; p < 0.001, one-sample t test). There is no difference between the computer group and the student group, suggesting that subjects of different ages behave similarly as long as they are computer users. | [4.0, 4.0, 5.0, 1.0, 5.0] | Medicine | train | 4 | tweets | 414133139586707456 |
10.1007/s00198-014-2732-3 | Medicine_tweet_102 | Calcium supplement intake and risk of cardiov... [Osteoporos Int. 2014] - PubMed - NCBI | At baseline, women who took calcium supplements had higher levels of physical activity, smoked less, and had lower trans fat intake compared with those who did not take calcium supplements. | Calcium supplement intake and risk of cardiov... [Osteoporos Int. 2014] - PubMed - NCBI | Results During 24 years of follow-up, 4,565 cardiovascular events occurred (2,709 CHD and 1,856 strokes). At baseline, women who took calcium supplements had higher levels of physical activity, smoked less, and had lower trans fat intake compared with those who did not take calcium supplements. After multivariable adjustment for age, body mass index, dietary calcium, vitamin D intake, and other CVD risk factors, the relative risk of CVD for women taking >1,000 mg/day of calcium supplements compared with none was 0.82 (95 % confidence interval [CI] 0.74 to 0.92; p for trend <0.001). | [3.0, 2.0, 3.0, 1.0, 3.0] | Medicine | train | 2.4 | tweets | 468539681773068288 |
10.1111/all.13333 | Medicine_tweet_104 | New paper: Influenza burden, prevention and treatment in asthma @username @username @username @username | Asthma patients seemed to have a higher risk of being admitted to the intensive care unit (ICU) or to have a more severe disease course when hospitalized for influenza, Severe disease was especially common in those developing pneumonia, but did not seem to be related to the severity of underlying asthma. | New paper: Influenza burden, prevention and treatment in asthma @username @username @username @username | Interestingly, influenza-related hospitalization costs in children with asthma may be lower than in children with other chronic conditions and were very close to costs in children without comorbidity. Asthma patients seemed to have a higher risk of being admitted to the intensive care unit (ICU) or to have a more severe disease course when hospitalized for influenza, Severe disease was especially common in those developing pneumonia, but did not seem to be related to the severity of underlying asthma. In a multivariate analysis of H1N1 pediatric patients, asthma was associated with increased mortality in ICU-admitted children and adolescents (OR 1.34, P = .05). | [2.0, 2.0, 4.0, 4.0, 3.0] | Medicine | train | 3 | tweets | 928044868596850689 |
10.1093/gerona/glt162 | Medicine_tweet_105 | RT @username New study: Chronological age is not a relevant marker for healthy #aging. | Our findings suggest that the time has arrived to reconsider the importance of chronological age and to design better social policies to reflect the substantial variation in health trajectories across the life span. | RT @username New study: Chronological age is not a relevant marker for healthy #aging. | Instead, different people appear to be experiencing widely different health trajectories with widely different health outcomes at the same ages. Our findings suggest that the time has arrived to reconsider the importance of chronological age and to design better social policies to reflect the substantial variation in health trajectories across the life span. These findings have important implications for five policy issues surrounding aging. | [3.0, 5.0, 5.0, 4.0, 4.0] | Medicine | train | 4.2 | tweets | 403280517866348544 |
10.1016/j.scitotenv.2019.04.266 | Medicine_tweet_107 | Conservation, bushmeat markets and health risks: Pruvot et al assessed health risks by conducting questionnaires with wildlife consumers in Laos and showed that consumption of bushmeat in urban areas was mostly driven by dietary preference and tradition
| Here again, a good understanding of wildlife consumer demography, economic status, and motivations is essential to the design of effective policy with limited unintended consequences on more vulnerable communities. | Conservation, bushmeat markets and health risks: Pruvot et al assessed health risks by conducting questionnaires with wildlife consumers in Laos and showed that consumption of bushmeat in urban areas was mostly driven by dietary preference and tradition
| This suggests that the cost of law enforcement can be internalized by wildlife vendors as part of their business operations, while this cost may not be tolerable at the individual level for a wildlife consumer. Here again, a good understanding of wildlife consumer demography, economic status, and motivations is essential to the design of effective policy with limited unintended consequences on more vulnerable communities. Doing so, we demonstrated high rates of direct contact between bushmeat and people visiting the market, highlighting that this may be an under-estimated route of disease transmission in the bushmeat system. | [4.0, 5.0, 1.0, 3.0] | Medicine | train | 3 | tweets | 1129283088607920129 |
10.1186/s10194-018-0916-5 | Medicine_tweet_108 | "Insomnia and migraine as closely related" as per researchers from South Korea representing various colleges – | Migraineurs with insomnia experienced a higher headache intensity and impact of headache (HIT-6 score) compared to migraineurs without insomnia (Table 3) . | "Insomnia and migraine as closely related" as per researchers from South Korea representing various colleges – | In contrast, insomnia has a significant impact on the clinical presentation of migraine. Migraineurs with insomnia experienced a higher headache intensity and impact of headache (HIT-6 score) compared to migraineurs without insomnia (Table 3) . It is possible that their distinct anatomy and pathophysiology contribute to the contrast findings. | [5.0, 3.0, 4.0, 4.0, 2.0] | Medicine | train | 3.6 | tweets | 1062586173812396032 |
10.1186/s12916-017-0986-2 | Medicine_tweet_109 | Old Age Alone Not to Blame for Surgical Complications. Study @username by @username Dr. Watt: #geriatrics @username | One study found that, while frail patients with postoperative complications had prolonged hospitalizations (P < 0.001), those without postoperative complications did not (P = 0.19) . | Old Age Alone Not to Blame for Surgical Complications. Study @username by @username Dr. Watt: #geriatrics @username | Among six studies that investigated frailty as a prognostic factor for prolonged hospitalization, there was a significant association identified in four studies . One study found that, while frail patients with postoperative complications had prolonged hospitalizations (P < 0.001), those without postoperative complications did not (P = 0.19) . Age was identified as a significant prognostic factor for prolonged hospitalization in only two of six studies 2 . | [2.0, 2.0, 4.0, 3.0] | Medicine | train | 2.75 | tweets | 951832472873967616 |
10.1073/pnas.1509654112 | Medicine_tweet_11 | Male and female brains are more similar than previously thought. Interesting paper in PNAS | Here we show that, although there are sex/gender differences in brain and behavior, humans and human brains are comprised of unique "mosaics" of features, some more common in females compared with males, some more common in males compared with females, and some common in both females and males. | Male and female brains are more similar than previously thought. Interesting paper in PNAS | Such an alignment may be predicted by the classic view of sexual differentiation of the brain, according to which masculinization and defeminization of the brain are under the sole influence of testosterone (9). Here we show that, although there are sex/gender differences in brain and behavior, humans and human brains are comprised of unique "mosaics" of features, some more common in females compared with males, some more common in males compared with females, and some common in both females and males. Our results demonstrate that regardless of the cause of observed sex/gender differences in brain and behavior (nature or nurture), human brains cannot be categorized into two distinct classes: male brain/female brain. | [5.0, 1.0, 4.0, 3.0] | Medicine | train | 5 | tweets | 671443107045621761 |
10.1038/nature12775 | Medicine_tweet_110 | #sr Stepwise-binding process w/ decreasing affinity:Structural basis for Ca2+ selectivity of voltage-gated Ca channel | This pore architecture suggests a conduction pathway involving transitions between two main states with one or two hydrated Ca 21 ions bound in the selectivity filter and supports a 'knock-off' mechanism of ion permeation through a stepwisebinding process. | #sr Stepwise-binding process w/ decreasing affinity:Structural basis for Ca2+ selectivity of voltage-gated Ca channel | Our results reveal interactions of hydrated Ca 21 with two high-affinity Ca 21 -binding sites followed by a third lower-affinity site that would coordinate Ca 21 as it moves inward. This pore architecture suggests a conduction pathway involving transitions between two main states with one or two hydrated Ca 21 ions bound in the selectivity filter and supports a 'knock-off' mechanism of ion permeation through a stepwisebinding process. The multi-ion selectivity filter of our Ca V Ab model establishes a structural framework for understanding the mechanisms of ion selectivity and conductance by vertebrate Ca V channels. | [4.0, 3.0, 3.0, 4.0] | Medicine | train | 3.5 | tweets | 406122131508846592 |
10.1001/jamapediatrics.2013.4951 | Medicine_tweet_111 | Feed & satiety response in INFANTS linked to obesity in childhood, this is where prevention begins @username . | Similar patterns are to be expected in the wider population; therefore, this study corroborates the hypothesis that a hearty appetite in infancy is a risk factor for faster weight gain. | Feed & satiety response in INFANTS linked to obesity in childhood, this is where prevention begins @username . | 25 Our findings indicate that within the same family the sibling with the higher appetite grows faster than the sibling with the lower appetite. Similar patterns are to be expected in the wider population; therefore, this study corroborates the hypothesis that a hearty appetite in infancy is a risk factor for faster weight gain. Our study has several strengths. | [4.0, 4.0, 4.0, 3.0] | Medicine | train | 3.75 | tweets | 435541800690794497 |
10.1001/jama.2013.277165 | Medicine_tweet_113 | The TAO RCT—#anticoagulation with #otamixaban in #ACS | At that time, the rates of the primary efficacy outcome in the higher-dose otamixaban group was 4.7% (the one selected to go forward) and was 5.6% in the UFH-pluseptifibatide group (adjusted RR, 0.848; 95% CI, 0.662-1.087) but the lower-dose group fulfilled the prespecified criteria for futility with a RR of more than 1 (primary efficacy outcome, 6.3%; RR, 1.130; 95% CI, 0.906-1.408) and was discontinued. | The TAO RCT—#anticoagulation with #otamixaban in #ACS | The design of the TAO trial has been published. At that time, the rates of the primary efficacy outcome in the higher-dose otamixaban group was 4.7% (the one selected to go forward) and was 5.6% in the UFH-pluseptifibatide group (adjusted RR, 0.848; 95% CI, 0.662-1.087) but the lower-dose group fulfilled the prespecified criteria for futility with a RR of more than 1 (primary efficacy outcome, 6.3%; RR, 1.130; 95% CI, 0.906-1.408) and was discontinued. Events occurring among patients who received the discontinued otamixaban dose were not considered in primary outcome analyses, which pertained only to participants randomized to the higher dose of otamixaban vs UFH plus eptifibatide, not to the low-dose otamixaban group. | [3.0, 2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.6 | tweets | 380062458775220225 |
10.1016/j.ejca.2017.11.022 | Medicine_tweet_115 | Red meat is not associated with breast cancer in the UK - HR 0.99. Very small association for processed meat.
Headlines witter on about bacon, but it's not mentioned in the paper.
| Of the eleven cohort studies, ten reported the association between red meat consumption and overall risk of breast cancer; of these, six also reported results separately for pre-menopausal and post-menopausal breast cancer. | Red meat is not associated with breast cancer in the UK - HR 0.99. Very small association for processed meat.
Headlines witter on about bacon, but it's not mentioned in the paper.
| A further five studies were excluded due to repeat analyses conducted on the same cohort and two due to inadequate exposure information; resulting in ten eligible cohort studies in addition to UK Biobank ( Figure 1) . Of the eleven cohort studies, ten reported the association between red meat consumption and overall risk of breast cancer; of these, six also reported results separately for pre-menopausal and post-menopausal breast cancer. The ten studies produced a pooled relative risk for breast cancer, overall, of 1.03 (95% CI 0.99-1.08) (Figure 2 ). | [2.0, 3.0, 1.0, 1.0] | Medicine | train | 1.75 | tweets | 948652066527825920 |
10.1098/rsbl.2014.0993 | Medicine_tweet_116 | Ephedra foeminea production of drops on fullmoons to attract insects for pollination:
This raises possibility that | The moon may further be crucial for pollinator attraction. | Ephedra foeminea production of drops on fullmoons to attract insects for pollination:
This raises possibility that | This fits well with our field sites in the Balkans, where a cloudy sky is rare in the summer and no high trees shade the environment. The moon may further be crucial for pollinator attraction. While investigated species of Gnetum emit easily detectable scent (C. Rydin 2014, personal observation and ), Ephedra does not. | [3.0, 2.0, 5.0, 1.0, 3.0] | Medicine | train | 3 | tweets | 583797469449945088 |
10.1001/jama.2018.20578 | Medicine_tweet_117 | Meta-analysis evaluating aspirin for primary prevention in cardiovascular disease – the double-edged sword: NNT 265 (to prevent CV mortality/nonfatal MI + stroke); NNH 210 (major bleeding). #JAMA #CVD
| The current study demonstrates that the absolute risk reduction for cardiovascular events and absolute risk increase for major bleeding associated with aspirin use were of similar magnitude. | Meta-analysis evaluating aspirin for primary prevention in cardiovascular disease – the double-edged sword: NNT 265 (to prevent CV mortality/nonfatal MI + stroke); NNH 210 (major bleeding). #JAMA #CVD
| 6 This study showed that when analysis was restricted to populations with observation-derived 10-year cardiovascular event rate estimates of 10% or more, aspirin use was associated with an absolute risk decrease of 0.51% (5% CI, 0.06%-0.3%) for the cardiovascular composite outcome, but an absolute risk increase of 0.64% (5% CI, 0.35%-0.7%) for major bleeding. The current study demonstrates that the absolute risk reduction for cardiovascular events and absolute risk increase for major bleeding associated with aspirin use were of similar magnitude. Aspirin use was not associated with a reduction in cardiovascular mortality, and deaths due to bleeding were rare. | [3.0, 5.0, 2.0, 4.0] | Medicine | train | 3.5 | tweets | 1087869932593926144 |
10.1001/jama.2013.277165 | Medicine_tweet_118 | #Anticoagulation With #Otamixaban and Ischemic Events in NSTE-ACS | Otamixaban consistently increased all types of bleeding events, regardless of the severity or bleeding classification scheme used (Table 2 ; and eTable 4 in the Supplement), and without interaction across patient subsets, including demographics, previous treatment, risk scores, biomarkers or management (eFigure 3B and eFigure 4 in the Supplement). | #Anticoagulation With #Otamixaban and Ischemic Events in NSTE-ACS | Patients in the otamixaban group had an increased rate of the primary safety outcome of TIMI major or minor bleeding at day 7 compared with patients in the combination of UFHplus-eptifibatide group (3.1% vs 1.5%; RR, 2.13 [95% CI, 1.63-2.78]; P < .001; Table 2 ). Otamixaban consistently increased all types of bleeding events, regardless of the severity or bleeding classification scheme used (Table 2 ; and eTable 4 in the Supplement), and without interaction across patient subsets, including demographics, previous treatment, risk scores, biomarkers or management (eFigure 3B and eFigure 4 in the Supplement). Study anticoagulant was discontinued because of bleeding in 242 patients (4.7%) in the otamixaban group and in 95 patients (1.7%) in the UFH-pluseptifibatide group (P < .001). | [4.0, 2.0, 2.0, 1.0, 2.0] | Medicine | train | 2.2 | tweets | 374109851703869440 |
10.1038/s41467-018-07557-4 | Medicine_tweet_12 | "We show that nearly four million people and 70% of current infrastructure in the permafrost domain are in areas with high potential for thaw of near-surface permafrost." .. "where thaw-related ground instability can cause severe damage"
| Here, the ground temperature and thaw of near-surface permafrost was considered to be the most important factor affecting infrastructure hazard followed by GIC, relative increase of ALT, fine-grained sediment content and slope gradient. | "We show that nearly four million people and 70% of current infrastructure in the permafrost domain are in areas with high potential for thaw of near-surface permafrost." .. "where thaw-related ground instability can cause severe damage"
| The AHP developed is a multi-objective, multicriteria decision-making approach to analyse complicated problems such as the determination of relative roles of factors affecting geohazards 70 . Here, the ground temperature and thaw of near-surface permafrost was considered to be the most important factor affecting infrastructure hazard followed by GIC, relative increase of ALT, fine-grained sediment content and slope gradient. 2). | [3.0, 4.0, 3.0, 2.0] | Medicine | train | 3 | tweets | 1073349529884336133 |
10.1001/jama.2018.20578 | Medicine_tweet_120 | In @username
Bottom line of this latest analysis calculates out as follows: For every 265 folks taking #aspirin for median 5 years, 1 #heartattack, #stroke or death is likely prevented & for every 210 folks on aspirin, 1 serious bleeding event occurs | In this meta-analysis, the use of aspirin in individuals without cardiovascular disease was associated with a lower risk of cardiovascular events and an increased risk of major bleeding. | In @username
Bottom line of this latest analysis calculates out as follows: For every 265 folks taking #aspirin for median 5 years, 1 #heartattack, #stroke or death is likely prevented & for every 210 folks on aspirin, 1 serious bleeding event occurs | 19, 22 Increasing adoption of additional primary prevention strategies, such as risk factor modification and development of public health initiatives, may limit the applicability of earlier studies to current practice. In this meta-analysis, the use of aspirin in individuals without cardiovascular disease was associated with a lower risk of cardiovascular events and an increased risk of major bleeding. This information may inform discussions with patients about aspirin for primary prevention of cardiovascular events and bleeding. | [4.0, 2.0, 4.0, 4.0, 4.0] | Medicine | train | 3.6 | tweets | 1087751911909089280 |
10.1002/ijc.28956 | Medicine_tweet_121 | Positive effect of primary prevention measures for melanoma? | As seen across all ages those diagnosed with lesions >1 mm were at higher risk of death of those with thin melanoma. | Positive effect of primary prevention measures for melanoma? | With regard to survival, Queensland melanoma patients in this young age group had virtually the same survival rate at around 96% as all Australians aged 0-19, 20- and 0-9 years from 199 to 200 and young adults aged 20-2 years in the USA, and better survival at 5 years than seen in Australians aged 60-69 (91%). As seen across all ages those diagnosed with lesions >1 mm were at higher risk of death of those with thin melanoma. The generally favourable outcome in Queensland is likely due in part to early detection resulting from increased skin cancer awareness. | [2.0, 2.0, 3.0, 4.0, 2.0] | Medicine | train | 2.6 | tweets | 464970007298846720 |
10.1186/s10194-018-0955-y | Medicine_tweet_122 | @username guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention just published on #TheJournalofHeadacheandPain and available at | Results: We found low to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in patients with episodic migraine and medium to high quality of evidence to recommend erenumab, fremanezumab, and galcanezumab in patients with chronic migraine. | @username guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention just published on #TheJournalofHeadacheandPain and available at | Results: We found low to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in patients with episodic migraine and medium to high quality of evidence to recommend erenumab, fremanezumab, and galcanezumab in patients with chronic migraine. For several clinical questions, there was not enough evidence to provide recommendations using the GRADE approach and recommendations relied on experts' opinion. Conclusion: Monoclonal antibodies acting on the calcitonin gene-related peptide are new drugs which can be recommended for migraine prevention. | [3.0, 2.0, 4.0, 1.0] | Medicine | train | 2.5 | tweets | 1085833674418020352 |
10.1016/j.biopsych.2013.07.024 | Medicine_tweet_123 | New study ( prenatal exposure to glucucorticoids or smoking raise adult daughters' nicotine dependence but not sons' | Given evidence for more pronounced MSDP-offspring smoking links in daughters (12-14, 16,17,19,24) and for sex differences in prenatal glucocorticoid levels (59) and offspring outcomes after prenatal glucocorticoid exposure (60), we also hypothesized that links between prenatal glucocorticoids and offspring ND would be stronger for daughters. | New study ( prenatal exposure to glucucorticoids or smoking raise adult daughters' nicotine dependence but not sons' | Thus, we propose that maternal cortisol levels might mediate the relation between MSDP and offspring ND. Given evidence for more pronounced MSDP-offspring smoking links in daughters (12-14, 16,17,19,24) and for sex differences in prenatal glucocorticoid levels (59) and offspring outcomes after prenatal glucocorticoid exposure (60), we also hypothesized that links between prenatal glucocorticoids and offspring ND would be stronger for daughters. showed associations between fetal testosterone exposure and alterations in responsiveness of neural reward regions and behavioral approach tendencies, both of which have been associated with ND . | [5.0, 4.0, 3.0, 3.0] | Medicine | train | 3.75 | tweets | 423478257359392768 |
10.1073/pnas.1204651110 | Medicine_tweet_124 | Severe drought has lasting effects on Amazon - Nature.comSevere drought has lasting effects... | We found no in situ observations over the region affected by the 2005 drought that could be used to directly verify our results. | Severe drought has lasting effects on Amazon - Nature.comSevere drought has lasting effects... | The delayed recovery of QSCAT in southwestern Amazonia suggests a decline in more long-lived aspects of canopy structure with recovery timescales greater than 3-4 y, such as loss of leaves or dieback of branches, or potential tree falls creating large gaps. We found no in situ observations over the region affected by the 2005 drought that could be used to directly verify our results. The effects of extreme droughts on the understory light environment of tropical forests may be compared with the effects of tree-fall gaps, although on much larger scales (27) . | [1.0, 2.0, 1.0] | Medicine | train | 1.333333 | tweets | 283317092286083072 |
10.1098/rsbl.2014.0255 | Medicine_tweet_125 | Galápagos hawk and feather lice showed patterns of co-divergence across temporal and spatial scales on the islands.
| Similarly, D. regalis showed an extraordinarily high degree of population genetic structure among geographical islands. | Galápagos hawk and feather lice showed patterns of co-divergence across temporal and spatial scales on the islands.
| Further analysis of the genetic clusters revealed a clear correspondence with the geographical islands on which populations were sampled. Similarly, D. regalis showed an extraordinarily high degree of population genetic structure among geographical islands. AMOVA and pairwise permutation tests showed that populations of lice on each island were highly differentiated (overall F ST ¼ 0.429, p , 0.0001). | [1.0, 3.0, 3.0] | Medicine | train | 2.333333 | tweets | 497496916322951168 |
10.1038/s41588-018-0175-z | Medicine_tweet_126 | Seeing an enhancer interact with a promoter to activate a gene in a living single cell, in real-time, for the 1st time (via genome editing and color imaging) @username by @username and colleagues @username | We show that sustained proximity of the enhancer to its target is required for activation. | Seeing an enhancer interact with a promoter to activate a gene in a living single cell, in real-time, for the 1st time (via genome editing and color imaging) @username by @username and colleagues @username | Even for a compact genome such as Drosophila melanogaster, at least 30% of enhancer-promoter interactions occur over 20 kb, and in many cases over intervening genes . We show that sustained proximity of the enhancer to its target is required for activation. Transcription in turn affects the three-dimensional topology as it enhances the temporal stability of the proximal conformation and is associated with further spatial compaction. | [4.0, 1.0, 5.0, 3.0] | Medicine | train | 3 | tweets | 1021412274429296640 |
10.1111/papt.12095 | Medicine_tweet_127 | Broad minded affective coping (BMAC), a therapeutic technique, effective to elicit positive memories | It would also be useful to evaluate this technique within a clinical group, where problems around accessing positive social memories and emotions will be more pronounced. | Broad minded affective coping (BMAC), a therapeutic technique, effective to elicit positive memories | In future research, it would be helpful to have a comparison group who complete a relaxation imagery exercise to allow for the exploration of change brought about by the social BMAC above that of relaxation alone. It would also be useful to evaluate this technique within a clinical group, where problems around accessing positive social memories and emotions will be more pronounced. Nonetheless, the current study helps us to establish a proof-of-concept regarding the social BMAC. | [3.0, 4.0, 3.0, 2.0] | Medicine | train | 3 | tweets | 723067166199713792 |
10.1016/j.jadohealth.2015.02.018 | Medicine_tweet_128 | RT @username: Academic study--Sexual assaults have reached epidemic levels among college women. #fem2 | Before entering college, 28% of women had experienced attempted or completed rape. | RT @username: Academic study--Sexual assaults have reached epidemic levels among college women. #fem2 | In addition, this study provides temporal resolution unavailable in most previous reports. Before entering college, 28% of women had experienced attempted or completed rape. During their first year, one of six female students had experienced A/C IR or A/C FR. | [1.0, 1.0, 3.0, 3.0, 4.0] | Medicine | train | 3 | tweets | 600982012313370624 |
10.1063/1.4913758 | Medicine_tweet_129 | @username @username If you want to argue that there is no social polarization in Venezuela, I don't know what to tell you. There are a whole lot of scholarly articles on this.
Even Venezuelan Twitter is polarized: | In fact, during this day the percentage of users tweeting from Venezuela (≈ 20%) was very low in comparison to the rest of the days (average around > 80%). | @username @username If you want to argue that there is no social polarization in Venezuela, I don't know what to tell you. There are a whole lot of scholarly articles on this.
Even Venezuelan Twitter is polarized: | Besides a large amount of users from all around the globe joined to the conversation, making the topic international, rather than local from Venezuela. In fact, during this day the percentage of users tweeting from Venezuela (≈ 20%) was very low in comparison to the rest of the days (average around > 80%). Hence, our set of Venezuelan elite were not capable of polarizing this majority of worldwide users. | [1.0, 3.0, 1.0, 2.0] | Medicine | train | 1.75 | tweets | 1100622633580851200 |
10.1016/j.jpsychires.2013.06.014 | Medicine_tweet_130 | Prisoners in 10-week #yoga course experienced improved behavioural control & decreased psychological distress: | Participation in the yoga course significantly influenced positive affect as measured by the PANAS, F(1,86) ¼ 5.26, p ¼ 0.024. | Prisoners in 10-week #yoga course experienced improved behavioural control & decreased psychological distress: | The average time that participants in the yoga group spent practising yoga (outside of class) did not differ significantly when compared to the time spent by the control group doing other forms of exercise (167.1 AE 48.4 min vs. 241.76 AE 27.0 min, respectively), t(75) ¼ À1.46, p ¼ 0.15. Participation in the yoga course significantly influenced positive affect as measured by the PANAS, F(1,86) ¼ 5.26, p ¼ 0.024. Exploration of simple effects demonstrated that participants did not differ in positive affect at baseline, F(1,86) < 1, but at Time 2 the yoga group reported significantly higher positive affect than the control group, F(1,86) ¼ 6.33, p ¼ 0.014. | [4.0, 3.0, 4.0, 4.0] | Medicine | train | 3.75 | tweets | 357523208028684288 |
10.1016/j.cell.2013.12.044 | Medicine_tweet_131 | Closer to bite free? RT @username: New Vosshall Lab CELL paper out today: Mosquitoes that can't sense carbon dioxide | The role of mosquito vision in host-seeking and its interactions with odors warrants further investigation. | Closer to bite free? RT @username: New Vosshall Lab CELL paper out today: Mosquitoes that can't sense carbon dioxide | In addition, it is possible that diurnal patterns of flight periodicity in Ae. The role of mosquito vision in host-seeking and its interactions with odors warrants further investigation. Neither chemosensory input in isolation fully encodes the experience of the food or beverage, which may explain why humans with olfactory dysfunction report difficulties with enjoyment of food and wine . | [4.0, 2.0, 1.0, 2.0, 4.0] | Medicine | train | 1 | tweets | 439155896846155777 |
10.1534/genetics.116.197285 | Medicine_tweet_132 | Paper on the Evolution of Resistance Against #CRISPR/Cas9 Gene Drive. | Thus, resistance is more likely to evolve from alleles in the SGV than from de novo mutation after introduction of the driver, unless the drive is very slow. | Paper on the Evolution of Resistance Against #CRISPR/Cas9 Gene Drive. | We find that in most scenarios P SGV is higher than P μ . Thus, resistance is more likely to evolve from alleles in the SGV than from de novo mutation after introduction of the driver, unless the drive is very slow. The key parameter determining the likelihood of resistance from NHEJ is the product N e δ, similar to the role played by θ = 4N e μ for de novo mutation. | [3.0, 1.0, 1.0, 3.0] | Medicine | train | 2 | tweets | 831607450742747137 |
10.1002/oby.20610 | Medicine_tweet_133 | Home-school #kids thinner, leaner, and have better #diet than public school kids #philosophy of #education #health | Traditional school status was associated with increased reported intake of trans fat (p=0.0136), total sugar (p=0.0342), added sugars (p=0.0164), calcium (p=0.0109), and decreased consumption of fiber (p=0.0408), and fruits and vegetables (p=0.0005). | Home-school #kids thinner, leaner, and have better #diet than public school kids #philosophy of #education #health | No significant differences were detected between TSC and HSC with respect to the amount of time spent engaged in daily moderate to vigorous physical activity. Traditional school status was associated with increased reported intake of trans fat (p=0.0136), total sugar (p=0.0342), added sugars (p=0.0164), calcium (p=0.0109), and decreased consumption of fiber (p=0.0408), and fruits and vegetables (p=0.0005). Being traditionally schooled was also nearly significantly associated with increased energy intake (p=0.0584). | [3.0, 2.0, 4.0, 3.0, 4.0] | Medicine | train | 3.2 | tweets | 391719121970544640 |
10.1016/j.amepre.2016.07.031 | Medicine_tweet_134 | Healthcare Provider Contact & PrEP in Baltimore Men Who Have Sex w Men [a] HT @username | Results: There were 401 HIV-negative participants, of whom 168 (42%) were aware of PrEP. | Healthcare Provider Contact & PrEP in Baltimore Men Who Have Sex w Men [a] HT @username | Results: There were 401 HIV-negative participants, of whom 168 (42%) were aware of PrEP. Visiting a healthcare provider in the past 12 months, receiving an HIV test from a provider, and having a sexually transmitted infection test in the past 12 months were not significantly associated with PrEP awareness. PrEP awareness was associated with being out to a healthcare provider (OR¼2.97, 95% CI¼1.78, 4.96, po0.001); being tested for HIV (OR¼1.50, 95% CI¼1.06, 2.13, p¼0.023); and receiving condoms from an HIV/AIDS CBO (OR¼2.59, 95% CI¼1.43, 4.64, p¼0.001). | [2.0, 2.0, 3.0, 4.0, 1.0] | Medicine | train | 2.4 | tweets | 784184031676071936 |
10.1089/apc.2017.0171 | Medicine_tweet_135 | Healthcare insurance barriers remain a major obstacle against proving #HIV prophylaxis to Black and Hispanic men who have sex with men.
| This finding is particularly troubling, given that the highest rates of new HIV infection are in the South, and southern blacks have a higher prevalence of HIV there than other ethnic groups. | Healthcare insurance barriers remain a major obstacle against proving #HIV prophylaxis to Black and Hispanic men who have sex with men.
| These regional disparities might reflect the more limited expansion of Medicaid in the south than in the rest of the country. This finding is particularly troubling, given that the highest rates of new HIV infection are in the South, and southern blacks have a higher prevalence of HIV there than other ethnic groups. Lower education frequently coincides with lower health literacy and reduced knowledge of preventive services such as PrEP. | [2.0, 2.0, 2.0, 3.0, 2.0] | Medicine | train | 2.2 | tweets | 948737570141278208 |
10.1001/jamapediatrics.2018.3101 | Medicine_tweet_136 | Association of Prenatal Exposure to Air Pollution With Autism and some media: It's complicated: | Meaning Reducing exposures of pregnant women to environmental nitric oxide may be associated with a reduction in autism spectrum disorder incidence in their children. | Association of Prenatal Exposure to Air Pollution With Autism and some media: It's complicated: | Findings In this population-based cohort study of 132 256 births, maternal exposure to nitric oxide during pregnancy was associated with increased risk of autism spectrum disorder in offspring. Meaning Reducing exposures of pregnant women to environmental nitric oxide may be associated with a reduction in autism spectrum disorder incidence in their children. The use of LUR models provides greater spatial resolution and the ability to capture small-scale, localized variation compared with reliance on air-quality monitoring data alone. | [4.0, 4.0, 4.0, 5.0, 4.0] | Medicine | train | 4.2 | tweets | 1064597051869155328 |
10.1073/pnas.1613193114 | Medicine_tweet_137 | #climatechange expected to have negative impact on US electric grid #climateandhealth #putkids1st #KidsEnvHealth | As such, even absent population and income changes, climate change will demand significant changes to the electric grid. | #climatechange expected to have negative impact on US electric grid #climateandhealth #putkids1st #KidsEnvHealth | Overall, if the US had faced, over the past decade, the warmer climate that scientists predict for the future, our results show that much greater generation or storage capacity would have been needed. As such, even absent population and income changes, climate change will demand significant changes to the electric grid. ERCOT covers Texas only and can be thought of as more representative of warmer regions. | [2.0, 5.0, 2.0, 5.0] | Medicine | train | 5 | tweets | 829353787303272448 |
10.1177/0956797614534694 | Medicine_tweet_138 | Fewer than 5 hrs of sleep had about 20% higher rate of reported a false memory & other effects | Planned comparisons revealed that in the morning-encoding condition, the false memory rate was significantly higher in the sleep-deprived group than in the rested group, t(51) = 2.01, p = .04 (two-tailed), Cohen's d = 0.56. | Fewer than 5 hrs of sleep had about 20% higher rate of reported a false memory & other effects | However, there was a significant interaction between the factors, F(1, 99) = 4.52, p = .04. Planned comparisons revealed that in the morning-encoding condition, the false memory rate was significantly higher in the sleep-deprived group than in the rested group, t(51) = 2.01, p = .04 (two-tailed), Cohen's d = 0.56. However, in the evening-encoding condition, there was no significant difference in the false memory rate between sleep-deprived and rested participants, t(52) = 0.98, p = .33 (Fig. | [4.0, 5.0, 4.0, 5.0, 3.0] | Medicine | train | 4.2 | tweets | 489700861963427840 |
10.1038/s41598-018-26198-7 | Medicine_tweet_139 | A new Harvard study found that when mice are randomized to either a stretching (10 minutes/day) vs. no stretching group, those in the stretching group had a 52% reduction in the growth of implanted breast cancer tumors growth... | Both active and passive stretching had similar effects compared with anesthesia alone, and there was no significant difference between the effects of active and passive stretching 23 . | A new Harvard study found that when mice are randomized to either a stretching (10 minutes/day) vs. no stretching group, those in the stretching group had a 52% reduction in the growth of implanted breast cancer tumors growth... | While our method of stretching does not fully suspend the animal, since its front feet are allowed to grip a bar of the cage, some stress inevitably results from being restrained by the tail, and muscle activity is required to maintain the stretched posture; in the no stretch group, we did not hold the mice by the tail, as they have a tendency to pull away which can cause inadvertent stretching of tissues. Both active and passive stretching had similar effects compared with anesthesia alone, and there was no significant difference between the effects of active and passive stretching 23 . This result demonstrated a mechanical effect of stretching that was not due to stress or muscle activity (since these were identical in the two anesthetized groups). | [4.0, 2.0, 1.0, 3.0] | Medicine | train | 2.5 | tweets | 999281918742016000 |
10.1098/rsos.150710 | Medicine_tweet_14 | Our new paper using MTurk finds no evidence that artificial monitoring cues influence online donations to charity | This work supports the importance of cultural differences and enduring individual differences in prosocial behaviour and shows that a range of artificial monitoring cues do not reliably boost online charity donation on MTurk. | Our new paper using MTurk finds no evidence that artificial monitoring cues influence online donations to charity | By contrast, the control variables of culture, age, sex and previous charity giving frequency did predict donations. This work supports the importance of cultural differences and enduring individual differences in prosocial behaviour and shows that a range of artificial monitoring cues do not reliably boost online charity donation on MTurk. None of the monitoring primes we tested had a significant effect on charitable giving. | [3.0, 4.0, 5.0, 5.0, 5.0] | Medicine | train | 4.4 | tweets | 788976892560805888 |
10.1126/scitranslmed.aah4066 | Medicine_tweet_140 | [Research Articles] Inflammasome inhibition prevents {alpha}-synuclein pathology and dopaminergic neurodegeneration in mice | Inflammasome components are up-regulated, and activation occurs via NLRP3 in the 6-OHDA mouse model of PD. | [Research Articles] Inflammasome inhibition prevents {alpha}-synuclein pathology and dopaminergic neurodegeneration in mice | Inflammasome components are up-regulated in patients with PD. Inflammasome components are up-regulated, and activation occurs via NLRP3 in the 6-OHDA mouse model of PD. NLRP3 and ASC are up-regulated in the MitoPark mouse model of PD. | [5.0, 1.0, 3.0, 3.0] | Medicine | train | 3 | tweets | 1057698005728485376 |
10.1016/j.socscimed.2018.10.008 | Medicine_tweet_141 | Research by Dr Sarah Johns identifies that male infants and birth complications increase chances of postnatal depression @username@username #BiologicalAnthropology #HealthMatters #depression #postnatal | We did not find much evidence for the additive effects of birth complications with other PND risk factors in our sample (low SES, low social support, and a history of depression, anxiety, and stress) as anticipated. | Research by Dr Sarah Johns identifies that male infants and birth complications increase chances of postnatal depression @username@username #BiologicalAnthropology #HealthMatters #depression #postnatal | Irrespective of whether post-birth infections are experienced, birth complications are likely to be stressful for women, particularly if they resulted in emergency procedures being undertaken. We did not find much evidence for the additive effects of birth complications with other PND risk factors in our sample (low SES, low social support, and a history of depression, anxiety, and stress) as anticipated. Only one predicted interaction effect was found; male infants increased PND risk when associated with complicated births when PND was measured by clinical diagnosis, but not when PND was determined retrospectively, and inclusion of the interaction term only marginally improved the model performance. | [1.0, 1.0, 3.0, 1.0] | Medicine | train | 1.5 | tweets | 1058329179685568513 |
10.1073/pnas.1515528113 | Medicine_tweet_142 | Cost-effectiveness of #hpv #vaccines: | Therefore, both cervical cancer incidence and expenditure can be substantially reduced if the states coordinate policies to promote expansion of coverage, particularly for the new nonavalent vaccine. | Cost-effectiveness of #hpv #vaccines: | Because of interstate migration and the long duration between HPV infection and resultant cervical cancer, much of the benefit of vaccination will be realized beyond a state's borders. Therefore, both cervical cancer incidence and expenditure can be substantially reduced if the states coordinate policies to promote expansion of coverage, particularly for the new nonavalent vaccine. Both of these vaccines are highly efficacious against HPV-16 and HPV-18 and are partially efficacious against other non-vaccine-targeted oncogenic serotypes . | [1.0, 4.0, 5.0, 4.0, 4.0] | Medicine | train | 4 | tweets | 722389929796304896 |
10.1186/s13059-018-1434-0 | Medicine_tweet_143 | Pretty convincing evidence of negative selection detectable in cancer exomes in contrast to Martincorena et al Cell 2017. Nice eg in TERT w +ve selection in promoter but -ve selection in exons. Makes good sense! | In summary, the presented evidence supports a major role of negative selection in cancer evolution, which has been neglected in most studies, and ultimately challenges the current paradigm of an exclusive role of positive selection in cancer. | Pretty convincing evidence of negative selection detectable in cancer exomes in contrast to Martincorena et al Cell 2017. Nice eg in TERT w +ve selection in promoter but -ve selection in exons. Makes good sense! | Interestingly, AP-1 is essential for MHC complex I downregulation and immune escape upon HIV infection . In summary, the presented evidence supports a major role of negative selection in cancer evolution, which has been neglected in most studies, and ultimately challenges the current paradigm of an exclusive role of positive selection in cancer. These studies help to shed light upon the mechanisms underlying immune evasion and provide insights for improving cancer immunotherapies in the future. | [4.0, 5.0, 3.0, 3.0] | Medicine | train | 3.75 | tweets | 1003045321730076673 |
10.1001/jama.2015.1693 | Medicine_tweet_144 | Study in @username on #stents vs meds for intracranial stenosis in @username | The 1-year primary outcome of stroke or hard TIA occurred in more patients in the stent group (21/58; 36.2% [95% CI, 24.0-49.9]) vs the medical group (8/53; 15.1% [95% CI, 6.7-27.6]) (P = .02). | Study in @username on #stents vs meds for intracranial stenosis in @username | Intracranial hemorrhage within 30 days occurred in more patients in the stent group (5/58; 8.6% [95% CI, 2.9%-19.0%]) vs none in the medical group (95% CI, 0%-5.5%) (P = .06). The 1-year primary outcome of stroke or hard TIA occurred in more patients in the stent group (21/58; 36.2% [95% CI, 24.0-49.9]) vs the medical group (8/53; 15.1% [95% CI, 6.7-27.6]) (P = .02). Worsening of baseline disability score (modified Rankin Scale) occurred in more patients in the stent group (14/58; 24.1% [95% CI, 13.9%-37.2%]) vs the medical group (6/53; 11.3% [95% CI,.0%]) (P = .09).The EuroQol-5D showed no difference in any of the 5 dimensions between groups at 12-month follow-up. | [3.0, 1.0, 1.0, 3.0, 5.0] | Medicine | train | 1 | tweets | 580482974388482048 |
10.1001/jama.2014.15690 | Medicine_tweet_145 | Aspirin - another drug that doesn't seem to make much difference in heart disease prevention in persons at risk | The 5-year cumulative primary outcome event rate was not significantly different between the groups (2.77% [95% CI, 2.40%-3.20%] for aspirin vs 2.96% [95% CI, 2.58%-3.40%] for no aspirin; hazard ratio [HR], 0.94 [95% CI, 0.77-1.15]; P = .54). | Aspirin - another drug that doesn't seem to make much difference in heart disease prevention in persons at risk | Patients with an occurrence of nonfatal stroke totaled 114 in the aspirin group and 108 in the no aspirin group; of nonfatal myocardial infarction, 20 in the aspirin group and 38 in the no aspirin group; of undefined cerebrovascular events, 3 in the aspirin group and 5 in the no aspirin group. The 5-year cumulative primary outcome event rate was not significantly different between the groups (2.77% [95% CI, 2.40%-3.20%] for aspirin vs 2.96% [95% CI, 2.58%-3.40%] for no aspirin; hazard ratio [HR], 0.94 [95% CI, 0.77-1.15]; P = .54). Aspirin significantly reduced incidence of nonfatal myocardial infarction (0.30 [95% CI, 0.19-0.47] for aspirin vs 0.58 [95% CI, 0.42-0.81] for no aspirin; HR, 0.53 [95% CI, 0.31-0.91]; P = .02) and transient ischemic attack (0.26 [95% CI, 0.16-0.42] for aspirin vs 0.49 [95% CI, 0.35-0.69] for no aspirin; HR, 0.57 [95% CI, 0.32-0.99]; P = .04), and significantly increased the risk of extracranial hemorrhage requiring transfusion or hospitalization (0.86 [95% CI, 0.67-1.11] for aspirin vs 0.51 [95% CI, 0.37-0.72] for no aspirin; HR, 1.85 [95% CI, 1.22-2.81]; P = .004). | [4.0, 5.0, 5.0, 1.0, 4.0] | Medicine | train | 5 | tweets | 548775937345859586 |
10.1016/j.mito.2018.08.001 | Medicine_tweet_146 | Dense article about the connection between disruption of cell function & chronic illness. I never thought of the role that mitochondria play in disease prevention.
| This switch in bioenergetics is protective to cells when capillaries have been disrupted and the availability of oxygen for aerobic metabolism is compromised. | Dense article about the connection between disruption of cell function & chronic illness. I never thought of the role that mitochondria play in disease prevention.
| With M1 polarization, energy-coupled mitochondrial oxygen consumption drops, and cellular energy production switches to glycolysis and lactate production. This switch in bioenergetics is protective to cells when capillaries have been disrupted and the availability of oxygen for aerobic metabolism is compromised. This treatment causes cells to enter CDR1, decreasing mitochondrial oxidative phosphorylation and increasing glycolysis. | [3.0, 2.0, 2.0, 2.0, 1.0] | Medicine | train | 2 | tweets | 1038881989355433984 |