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10.1073/pnas.1803839115 | Medicine_482 | Modeling and testing strategies that enable learning, attention, sensory processing and other functions in a computer can motivate and suggest new biological experiments that probe the mechanisms of intelligence both natural and artificial, the researchers said. | Humans and other advanced animals can rapidly learn new rules or tasks, in contrast to the thousands of data points usually required for ANNs to accurately perform new tasks. | The computational research also benefits the laboratory's original focus on better understanding the primate brain by recording its activity as animals learn and behave. Modeling and testing strategies that enable learning, attention, sensory processing and other functions in a computer can motivate and suggest new biological experiments that probe the mechanisms of intelligence both natural and artificial, the researchers said. "Adding in this component of research to the lab has really opened a lot of doors in terms of allowing us to think about new kinds of problems, new kinds of neuroscience topics and problems that we normally can't really address using the experimental techniques currently available to us in the lab," Freedman said. | To our knowledge, these numbers of tasks are an order of magnitude greater compared to previously published work Nguyen et al., 2017; . Humans and other advanced animals can rapidly learn new rules or tasks, in contrast to the thousands of data points usually required for ANNs to accurately perform new tasks. This is because most new tasks are at least partially similar to tasks or contexts that have been previously encountered, and one can use past knowledge learned from these similar tasks to help learn the rules and contingencies of the new task. | [1.0, 4.0, 2.0, 3.0, 2.0] | Medicine | train | 2.4 | news | http://ct.moreover.com/?a=37417668602&p=1pl&v=1&x=xwt2GQA4KNm3ZCC-rb8usg |
10.1080/00224499.2013.843148 | Medicine_485 | Teens want to discuss more than sex. | Among this sexually active sample, 20 adolescents (38%) reported they had not used condoms every time they had sex in the past year, and 9 youth (17%) reported they had not discussed any sexual health topics with their dating partners. | On a personal note, when I speak with my own kids about sex, I am upfront and honest. Teens want to discuss more than sex. More than a third reported they wanted more guidance on how to have a mature relationship, handle breakups and how to not get hurt in a relationship. | Of the 603 7th and 8th graders that we sampled, 53 (8.8%; 29 girls, 24 boys) had engaged in sexual intercourse in the past year and 23 (3.8%; 12 girls, 11 boys) had had sex with two or more partners. Among this sexually active sample, 20 adolescents (38%) reported they had not used condoms every time they had sex in the past year, and 9 youth (17%) reported they had not discussed any sexual health topics with their dating partners. In addition, when asked about use of protection at first intercourse, 29 youth (55%) reported they had used a condom, and 8 of these adolescents (15%) indicated they had used both condoms and birth control pills the first time they had sex. | [2.0, 1.0, 3.0, 2.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=34612105223&p=1pl&v=1&x=ZML-98OfCDRtz_WfrGcLMw |
10.1016/j.amjmed.2013.04.026 | Medicine_486 | The findings reveal the importance of keeping up a higher level of physical activity--especially as we age. | Compared with women with waist circumference <71 cm, the multivariate-adjusted RR for waist circumference >88 cm was 1.27 (95% CI 1.17, 1.38). | It turns out that hearing loss may be associated with obesity in women. The findings reveal the importance of keeping up a higher level of physical activity--especially as we age. Yet it turns out that there may now be ways to offset this hearing loss. | Compared with women with BMI <25 kg/m 2 , the multivariateadjusted relative risk (RR) for women with BMI ≥ 40 was 1.25 (95% CI 1.14,1.37). Compared with women with waist circumference <71 cm, the multivariate-adjusted RR for waist circumference >88 cm was 1.27 (95% CI 1.17, 1.38). Higher physical activity was inversely related to risk; compared with women in the lowest quintile of physical activity, the multivariateadjusted RR for women in the highest quintile was 0.83 (95% CI 0.78,0.88). | [4.0, 2.0, 1.0, 2.0] | Medicine | train | 2.25 | news | http://www.scienceworldreport.com/articles/11159/20131125/obesity-linked-higher-risk-hearing-loss-women.htm |
10.1111/papt.12095 | Medicine_487 | Increasing positive emotion can have a range of benefits including reducing attention to and experiences of threat. | It would also be useful to evaluate this technique within a clinical group, where problems around accessing positive social memories and emotions will be more pronounced. | Increasing positive emotion can have a range of benefits including reducing attention to and experiences of threat. It was expected that the results would help to indicate when the social BMAC may be used most effectively in clinical settings. Social safeness increased
The study found that that safe/warm positive affect, relaxed positive affect and feelings of social safeness increased following the social BMAC, whilst negative affect decreased. | In future research, it would be helpful to have a comparison group who complete a relaxation imagery exercise to allow for the exploration of change brought about by the social BMAC above that of relaxation alone. It would also be useful to evaluate this technique within a clinical group, where problems around accessing positive social memories and emotions will be more pronounced. Nonetheless, the current study helps us to establish a proof-of-concept regarding the social BMAC. | [4.0, 5.0, 4.0, 1.0, 2.0] | Medicine | train | 1 | news | http://www.science20.com/news_articles/can_positive_memories_help_treat_mental_health_problems-170898 |
10.1038/s41467-018-05321-2 | Medicine_488 | This finding proved that blocking SUMO proteases with new drugs could reduce inflammation, and in the future could treat inflammatory diseases. | Signal II triggers loss of sumoylation of NLRP3. | They also found that blocking a further set of proteins called SUMO proteases - which themselves deactivate SUMOs - raised the levels of SUMO proteins. This finding proved that blocking SUMO proteases with new drugs could reduce inflammation, and in the future could treat inflammatory diseases. "New drugs that block activation of inflammasomes could, in the future, be used to treat inflammatory diseases that involve aberrant activation of the immune response, including cancer." | Taken together, these results indicate that NLRP3 is sumoylated in murine macrophages and human cells. Signal II triggers loss of sumoylation of NLRP3. Accordingly, we found that treatment with the bacterial toxin nigericin induced notable reduction of sumoylated NLRP3 ( Fig. | [1.0, 1.0, 1.0, 2.0, 2.0] | Medicine | train | 1.4 | news | http://ct.moreover.com/?a=37233930820&p=1pl&v=1&x=Aa6nBM2K5KAVpqdJ0YaxGg |
10.1016/j.bbr.2018.07.009 | Medicine_489 | Using animal models, Thanos found that regular aerobic exercise (one hour on a treadmill, five times a week) decreased stress-induced cocaine-seeking behavior. | 5) . | Using animal models, Thanos found that regular aerobic exercise (one hour on a treadmill, five times a week) decreased stress-induced cocaine-seeking behavior. Exercise also altered behavioral and physiological responses to stress. "Our results suggest that regular aerobic exercise could be a useful strategy for relapse prevention, as part of a comprehensive treatment program for recovering cocaine abusers," Thanos says. | 4) . 5) . A two way repeated measures ANOVA (between-subjects factor: exercise, within-subjects factor: stress) found no significant main effect of exercise treatment on corticosterone levels [F (1,22) costerone levels between sedentary and exercise rats (p > 0.05). | [1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34769125656&p=1pl&v=1&x=Q5cXML0nZW69IoP-wAIe9A |
10.1038/s41589-018-0155-8 | Medicine_49 | The team found that in adult mice, reducing ABHD12 activity with the inhibitor led to a rise in lyso-PS in immune cells called macrophages, as well as in brain tissue. | We also found that DO264 inhibits ABHD12 activity ( Supplementary Fig. | "This is a good example of how the study of a rare genetic disease can reveal a pathway that plays a key role in human biology," says study co-senior author Benjamin Cravatt, professor and chair of the Department of Chemical Physiology at Scripps Research. The team found that in adult mice, reducing ABHD12 activity with the inhibitor led to a rise in lyso-PS in immune cells called macrophages, as well as in brain tissue. The rise wasn't as great as that seen in the ABHD12-knockout mice, and even four weeks of treatment with the inhibitor appeared to cause only slight hearing defects -- nothing like the profound defects experienced by PHARC patients. | ), which adopt a more macrophage-like cell state compared to undifferentiated THP-1 cells. We also found that DO264 inhibits ABHD12 activity ( Supplementary Fig. 16 ) and alters lyso-PS and PS content in primary human macrophages, which showed elevations in both lyso-PS and 20:4 PS following 4 or 24 h treatment with DO264 (1 µ M), but not (S)-DO271 (1 µ M) ( Fig. | [4.0, 5.0, 1.0] | Medicine | train | 4 | news | http://ct.moreover.com/?a=37814264274&p=1pl&v=1&x=fV_-TrzPs9X1ZtNnkmq4RQ |
10.1038/d41586-018-04813-x | Medicine_491 | These studies raise ethical questions whether the subject is an animal or an AI. | Is there a point at which we should be concerned about the welfare of brain surrogates or chimaeras, such that assigning someone loosely akin to a guardian or decision-maker for the brain surrogate might be warranted, beyond the researchers involved? | The premiere of the second season of Westworld is a perfect time to ponder what makes us human. These studies raise ethical questions whether the subject is an animal or an AI. Yet as our models become more and more like the real thing (and for now, they are still quite a long way off), the problems with using them become so pronounced as to negate their utility--like Borges' map. | When people undergoing in vitro fertilization procedures choose to donate excess embryos to research, for instance, they are assured that these will not be used to create a baby. Is there a point at which we should be concerned about the welfare of brain surrogates or chimaeras, such that assigning someone loosely akin to a guardian or decision-maker for the brain surrogate might be warranted, beyond the researchers involved? Such an arrangement would be similar to the appointment of a guardian ad litem in custody disputes involving children in the United States (someone besides the parents who can represent the child's interests). | [4.0, 3.0, 3.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33910842388&p=1pl&v=1&x=rFhRGsT2IZi6idGW_Ok3MA |
10.1016/j.cell.2013.12.044 | Medicine_493 | By relying on several factors, the insect has a better chance of a really juicy bite when given a choice of targets. | The role of mosquito vision in host-seeking and its interactions with odors warrants further investigation. | It makes no sense for an animal (even a mosquito) to go bite anything that's warm if the blood thus harvested is nutritionally inadequate. By relying on several factors, the insect has a better chance of a really juicy bite when given a choice of targets. This research translates into practical information when designing chemical repellents to block mosquitoes from spreading malaria. | In addition, it is possible that diurnal patterns of flight periodicity in Ae. The role of mosquito vision in host-seeking and its interactions with odors warrants further investigation. Neither chemosensory input in isolation fully encodes the experience of the food or beverage, which may explain why humans with olfactory dysfunction report difficulties with enjoyment of food and wine . | [4.0, 2.0, 1.0, 3.0] | Medicine | train | 2.5 | news | http://guardianlv.com/2014/03/mosquitoes-select-their-targets-using-a-combination-of-sensory-cues/ |
10.1126/scitranslmed.aah4066 | Medicine_494 | In contrast, a-synuclein did not stimulate the release of IL-1b from microglia obtained from NLRP3-knockout mice. | Inflammasome components are up-regulated, and activation occurs via NLRP3 in the 6-OHDA mouse model of PD. | ... fibrillar a-synuclein mediates a delayed but robust activation of the inflammasome pathway in microglia," the team writes. In contrast, a-synuclein did not stimulate the release of IL-1b from microglia obtained from NLRP3-knockout mice. Their in vitro tests confirmed that MCC950 blocked mediators of microglial inflammasome activation by a-synuclein aggregates. | Inflammasome components are up-regulated in patients with PD. Inflammasome components are up-regulated, and activation occurs via NLRP3 in the 6-OHDA mouse model of PD. NLRP3 and ASC are up-regulated in the MitoPark mouse model of PD. | [1.0, 4.0, 2.0, 2.0, 2.0] | Medicine | train | 2.2 | news | http://ct.moreover.com/?a=37562808671&p=1pl&v=1&x=dc1ZI8yMrgwAVLaLhUUa7Q |
10.1186/s40479-014-0023-4 | Medicine_495 | Since dreaming mostly occurs during REM sleep, a complete lack of dreams could indicate that you arenat dropping into REM at all a which means that your sleep cycle is way out of whack. | Future studies should concentrate on ambulatory polysomnographic recordings to investigate sleep in natural environments to detect sleep and dream complaints in people with nightmares. | Most people dream, even if they canat remember their dreams; whatas more, whether or not you remember your dreams actually doesnat say anything at all about the quality of your sleep. Since dreaming mostly occurs during REM sleep, a complete lack of dreams could indicate that you arenat dropping into REM at all a which means that your sleep cycle is way out of whack. If you have sleep apnea, this might be something you experience regularly. | Therefore, nightmares should be seen as a distinct sleep disorder with specific symptoms that needs specific treatment. Future studies should concentrate on ambulatory polysomnographic recordings to investigate sleep in natural environments to detect sleep and dream complaints in people with nightmares. Furthermore, the difference between nightmare distress and nightmare frequency should be regarded which may lead to new insights concerning objective sleep measures. | [4.0, 2.0, 2.0, 2.0] | Medicine | train | 2.5 | news | http://ct.moreover.com/?a=38986009666&p=1pl&v=1&x=B3U6MA4BMyLJIproaHuz1Q |
10.1007/s12110-018-9323-5 | Medicine_496 | Scientists found that this hormonal and psychological shift made men more inclined to approach new potential partners. | Moreover, the contrasting changes in testosterone in winners and losers significantly predicted the changes in SPMV, Child Involvement, and M-P Trade-off in the groups following the manipulation. | Scientists found that this hormonal and psychological shift made men more inclined to approach new potential partners. The body attempts to take advantage of this apparent status improvement by inducing chemical and consequently behavioural changes that promote a "short-term" approach to reproductive success, say the researchers. "We found that a perceived shift in social status can cause male physiology to adapt by preparing to shift mating strategies to optimise reproductive success." | Furthermore, winners exhibited a tendency toward increased sociosexuality, a measure of engaging in casual, uncommitted sexual relationships. Moreover, the contrasting changes in testosterone in winners and losers significantly predicted the changes in SPMV, Child Involvement, and M-P Trade-off in the groups following the manipulation. Both post-race testosterone and SPMV levels were significant correlates of the post-race outcome measures, whereas self-esteem was only correlated with men's likelihood of becoming involved with children, and consequently with the M-P Trade-off. | [3.0, 2.0, 3.0, 3.0, 3.0] | Medicine | train | 2.8 | news | http://ct.moreover.com/?a=34770036725&p=1pl&v=1&x=maeovqxLeM8k2R-pmDJURA |
10.1016/j.ccell.2014.10.003 | Medicine_497 | "Our study confirmed that the fusion gene ASPSCR1-TFE3 causes ASPS; it's the driver." | Despite the already reported high expression of Hif1a and proangiogenic genes in ASPS, we demonstrated that these tumors lack frank hypoxia. | "That would be the ideal route to new and effective treatments. "Our study confirmed that the fusion gene ASPSCR1-TFE3 causes ASPS; it's the driver." Only 50 to 100 cases of ASPS are diagnosed in the United States each year, but this research bears on a fundamental question of cancer research: "How does a cancer start?" | This model revealed an unusual anatomic distribution, which has implications with regard to cell of origin and the metabolic microenvironment. Despite the already reported high expression of Hif1a and proangiogenic genes in ASPS, we demonstrated that these tumors lack frank hypoxia. When provided exogenous administration of lactate, the tumors responded with enhanced proliferation and angiogenesis, suggesting that lactate, not hypoxia, contributes to this unique form of sarcomagenesis. | [3.0, 2.0, 2.0, 2.0, 2.0] | Medicine | train | 2.2 | news | http://www.sciencedaily.com/releases/2014/11/141126123921.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1177/1745691613518075 | Medicine_498 | Benefits of meta-synthesis for big data
Aside from the study results, Krizan said other researchers can benefit from using the meta-synthesis method. | To our knowledge, we are among the first in psychological science to use metasynthesis, and the present article could serve as a template for later researchers using this analytic technique. | "If people are evaluating themselves in terms of very specific criteria, they're going to have better self-insight because they are constrained by how to interpret the ability." Benefits of meta-synthesis for big data
Aside from the study results, Krizan said other researchers can benefit from using the meta-synthesis method. Krizan says this type of analysis is a way to use the volume of big data that already exists. | Researchers in these situations may consider adopting a metasynthetic approach to derive a robust estimate of population effects. To our knowledge, we are among the first in psychological science to use metasynthesis, and the present article could serve as a template for later researchers using this analytic technique. There were several limitations to the use of metasynthesis for evaluating self-insight of ability across domains. | [2.0, 4.0, 3.0, 3.0, 5.0] | Medicine | train | 3.4 | news | http://www.newswise.com/articles/why-we-think-we-re-good-at-something-when-we-re-not |
10.1186/s40575-015-0014-9 | Medicine_499 | When making breeding decisions, genetic testing needs to be considered alongside health screening and family history. | Comparing historic photos of breed champions to their modern day kin, it is readily apparent that there has been selection towards exaggerated phenotypes among some breeds. | This approach has been successful in generating Dalmatians lacking a genetic defect that causes kidney stones, which is common in the breed. When making breeding decisions, genetic testing needs to be considered alongside health screening and family history. That will help to keep as much genetic diversity as possible in our pedigree dogs and, at the same time, reduce the prevalence of inherited diseases." | None are more dependent on human intervention than breeds of extreme skull shapes and size. Comparing historic photos of breed champions to their modern day kin, it is readily apparent that there has been selection towards exaggerated phenotypes among some breeds. The "stop" (the angle formed by the rostrum and forehead) is more acute in today's St. Bernard and the "Roman nose" of the Bull Terrier angulates more ventrally than it did decades ago . | [2.0, 2.0, 2.0, 3.0, 1.0] | Medicine | train | 2 | news | http://www.sciencedaily.com/releases/2015/03/150304124137.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1016/j.jpeds.2017.10.028 | Medicine_50 | The study identified a significant association between corporal punishment during childhood and violence toward dating partners in adulthood. | One factor that merits additional attention is the association between a youth's history of experiencing corporal punishment and perpetration of dating violence. | About 19 percent said they had committed some form of dating violence and 69 percent said they were physically punished during childhood. The study identified a significant association between corporal punishment during childhood and violence toward dating partners in adulthood. Specifically, people who got spanked as kids had a 29 percent higher risk for perpetrating dating violence, the findings showed. | 9 These factors cut across various domains including affective (eg, emotion dysregulation, psychiatric disorder), cognitive (eg, attitudes toward women, beliefs about violence), demographic (eg, age, race, sex, sexual orientation, socioeconomic status), interpersonal (eg, relationship satisfaction, problem solving skills), contextual (eg, availability of weapon, drug/alcohol use), as well as distal factors (eg, history of child abuse, exposure to family violence). One factor that merits additional attention is the association between a youth's history of experiencing corporal punishment and perpetration of dating violence. Attaining a better understanding of antecedents of dating violence is critical for preventive strategies seeking to mitigate dating violence among youth. | [4.0, 4.0, 4.0] | Medicine | train | 4 | news | http://ct.moreover.com/?a=32686504555&p=1pl&v=1&x=J_KXigEKTcXYUPzjI0fyuQ |
10.1038/s41467-018-05031-9 | Medicine_500 | In her study, Jone Michelena has already identified such a combination, which inhibits cancer cell proliferation to a significantly higher extent than the combination's individual components by themselves. | However, compared to microscopy-based measurements the sensitivity of both western blot and flow cytometry was extenuated and the lack of high-resolution cell images represents an additional limitation that precludes analyses of PARPi-induced changes at the subcellular level (see below). | Doing so can reveal which cell functions are needed for a certain drug to take effect.In addition, mechanisms of drug combinations can be analyzed in great detail. In her study, Jone Michelena has already identified such a combination, which inhibits cancer cell proliferation to a significantly higher extent than the combination's individual components by themselves. "We hope that our approach will make the search for strategies to combat cancer even more efficient," says Matthias Altmeyer, head of the research group at the Department of Molecular Mechanisms of Disease at UZH.Jone Michelena, Aleksandra Lezaja, Federico Teloni, Thomas Schmid, Ralph Imhof, Matthias Altmeyer. | Also flow cytometry revealed olaparib-induced γH2AX signaling in S-phase cells (Supplementary Figure 1g ). However, compared to microscopy-based measurements the sensitivity of both western blot and flow cytometry was extenuated and the lack of high-resolution cell images represents an additional limitation that precludes analyses of PARPi-induced changes at the subcellular level (see below). All compounds resulted in clearly detectable S-phase specific γH2AX signaling after just 4 h of exposure, with niraparib having the strongest and PJ-34 the weakest effect (Fig. | [2.0, 2.0, 3.0, 1.0, 1.0] | Medicine | train | 1.8 | news | http://ct.moreover.com/?a=34516153762&p=1pl&v=1&x=eQWXvJNP_ZAMG9EbtqgrOA |
10.1167/iovs.07-0804 | Medicine_501 | If you're reading this, there's a good chance you spend much of your working day and leisure time staring at a computer screen. | Of all near-work activities, only the time spent reading for pleasure was independently associated with SER after adjustment for age, sex, ethnicity, and school type (P trend ϭ 0.02, Table 2 ). | If you're reading this, there's a good chance you spend much of your working day and leisure time staring at a computer screen. You probably spend less time thinking about what it's doing to your eyes. Many people are vaguely aware, though, that all that staring isn't great -- reflected in the dry, fatigued eyes they experience after a long day of work. | Less total near work was reported by the children of European Caucasian ethnicity than by those of East Asian ethnicity and by those attending public comprehensive schools than by those attending other school types (Table 1) . Of all near-work activities, only the time spent reading for pleasure was independently associated with SER after adjustment for age, sex, ethnicity, and school type (P trend ϭ 0.02, Table 2 ). In general, there was only a very weak correlation between SER and hours spent in near-work activities (correlation coefficient for all, r Յ Ϫ0.2; Table 3 ). | [1.0, 1.0, 1.0, 2.0, 2.0] | Medicine | train | 1.4 | news | http://www.vox.com/2014/8/5/5967487/computer-screen-eyesight-vision |
10.1038/nature12775 | Medicine_503 | advertisement
The third site, with a lower binding affinity, allows the calcium ions to move into the cell. | This pore architecture suggests a conduction pathway involving transitions between two main states with one or two hydrated Ca 21 ions bound in the selectivity filter and supports a 'knock-off' mechanism of ion permeation through a stepwisebinding process. | This role is supported by the second site inside the pore. advertisement
The third site, with a lower binding affinity, allows the calcium ions to move into the cell. The flow of ions is accelerated by having these three binding sites in sequence. | Our results reveal interactions of hydrated Ca 21 with two high-affinity Ca 21 -binding sites followed by a third lower-affinity site that would coordinate Ca 21 as it moves inward. This pore architecture suggests a conduction pathway involving transitions between two main states with one or two hydrated Ca 21 ions bound in the selectivity filter and supports a 'knock-off' mechanism of ion permeation through a stepwisebinding process. The multi-ion selectivity filter of our Ca V Ab model establishes a structural framework for understanding the mechanisms of ion selectivity and conductance by vertebrate Ca V channels. | [3.0, 3.0, 4.0, 4.0] | Medicine | train | 3.5 | news | http://www.sciencedaily.com/releases/2013/11/131124200508.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1038/s41419-018-0765-9 | Medicine_504 | Reversal of the mutation restored mitochondrial function, as well as the skin and hair pathology. | Instead, follicles contained predominantly keratinaceous debris with only a few developing hair shafts which were fragmented and malformed. | The mitochondria of induced-mutation mice had reduced mitochondrial DNA content, altered mitochondrial gene expression, and instability of the large complexes in mitochondria that are involved in oxidative phosphorylation. Reversal of the mutation restored mitochondrial function, as well as the skin and hair pathology. This showed that mitochondria are reversible regulators of skin aging and loss of hair, an observation that Singh calls "surprising." | 6d ) in mtDNA-depleter compared with wild-type mice, these follicles were aberrant and did not produce normal hair shafts in mtDNA-depleter mice. Instead, follicles contained predominantly keratinaceous debris with only a few developing hair shafts which were fragmented and malformed. Thus, alopecia was not due to loss of hair follicles or cessation of cycling; rather, the follicles were dysfunctional and could not produce normal hair shaft or completely lost this capability. | [2.0, 3.0, 3.0, 2.0, 2.0] | Medicine | train | 2.4 | news | http://ct.moreover.com/?a=34590725905&p=1pl&v=1&x=7f-YQHjEdaZi0GdLFEWbxQ |
10.1093/molbev/mst211 | Medicine_506 | Their work suggests that a genetic mutation that makes certain people sensitive to the taste of a bitter compound appears to have been advantageous for certain human populations in Africa. | Individuals with the common derived G-allele at position 665 had a lower mean salicin score compared with individuals with two common haplotypes, but the difference in mean score was not statistically significant (P = 0.382 in Central Africa; P = 0.425 in East Africa) (supplementary table S8, Supplementary Material online). | For this reason, the ability to sense bitterness likely played an important role in human evolution. Their work suggests that a genetic mutation that makes certain people sensitive to the taste of a bitter compound appears to have been advantageous for certain human populations in Africa. Yet the reason why this trait was selected may not have to do with just taste. | This analysis showed a significant difference in mean salicin sensitivity between genotypic classes (P = 0.035 in Central Africa; P = 0.033 in East Africa) (supplementary table S7, Supplementary Material online), with individuals possessing at least one derived T-allele having a higher mean score than individuals homozygous for the ancestral G-allele, indicating a functional difference between these polymorphisms (supplementary table S7, Supplementary Material online) consistent with in vitro analyses by . Individuals with the common derived G-allele at position 665 had a lower mean salicin score compared with individuals with two common haplotypes, but the difference in mean score was not statistically significant (P = 0.382 in Central Africa; P = 0.425 in East Africa) (supplementary table S8, Supplementary Material online). This univariate analysis also showed no significant difference (P = 0.933 in Central Africa; P = 0.589 in East Africa) in mean salicin score between groups with and without additional nonsynonymous variants (supplementary table S9, Supplementary Material online). | [3.0, 2.0, 1.0, 4.0, 4.0] | Medicine | train | 2.8 | news | http://www.sciencedaily.com/releases/2013/11/131111185522.htm |
10.1098/rspb.2014.2120 | Medicine_507 | The researchers found that when the seals put on enough fat to achieve neutral buoyancy, the number of strokes needed to complete a round-trip from bottom to surface was at its lowest. | Seals gradually became more buoyant as they increased their fat stores while foraging over the course of the migration. | This means that she's negatively buoyant when she heads back out to sea and can sink into the deep water without swimming very hard. The researchers found that when the seals put on enough fat to achieve neutral buoyancy, the number of strokes needed to complete a round-trip from bottom to surface was at its lowest. "At neutral buoyancy, they're able to spend more time foraging at depth because they're spending less energy moving up and down," said Costa. | At the start of each migration, all 14 seals were negatively buoyant, as indicated by the negative drift rate values (figure 1; electronic supplementary material, figure S3 ). Seals gradually became more buoyant as they increased their fat stores while foraging over the course of the migration. All seals were still negatively buoyant at the end of the short foraging migration, but five of seven seals became neutrally buoyant by the end of the recording period during the long foraging migration, as indicated by the drift rates being zero (i.e. | [5.0, 4.0, 3.0, 5.0, 4.0] | Medicine | train | 4.2 | news | http://www.scienceworldreport.com/articles/18617/20141105/benefits-being-fat-obese-elephant-seals-dive-better.htm |
10.1073/pnas.1323342111 | Medicine_508 | "When a fear face was incorrectly judged as happy, the neurons responded as if a happy face was correctly judged as happy -- in a sense, "correctly" representing the patient's incorrect judgment. | This suggests that amygdala neurons encode whole-face information and emotion independently. | The team observed this also occurred when the neurons made and incorrect judgment about the face in question. "When a fear face was incorrectly judged as happy, the neurons responded as if a happy face was correctly judged as happy -- in a sense, "correctly" representing the patient's incorrect judgment. When a happy face was incorrectly judged as a fear face, the neurons responded as if a fear face had been correctly judged as fear -- again, reinforcing the 'correctness' of the incorrect decision. | We found 3 out of 24 (12.5%) fear-selective cells and 5 out of 17 (29.4%) happyselective cells are also whole-face-selective, a ratio of whole-face cells similar to that found in the entire population (36 out of 185, 19.5%). This suggests that amygdala neurons encode whole-face information and emotion independently. We found that face information conveyed by the eyes, but not the mouth region, modulated emotion-selective neuronal responses. | [3.0, 4.0, 3.0, 3.0, 4.0] | Medicine | train | 3.4 | news | http://www.hngn.com/articles/35346/20140704/brain-region-responds-to-subjective-perceptions.htm |
10.1186/1472-6920-12-82 | Medicine_510 | Such pay gap is of more concern given that both genders go through the same training and take similar risks. | However, the significance of gender influence, stating the higher aspirations of women for general practice is not very strong (see table 4, Model 1: p = 0.046). | In USA, male physicians earned about 25% more than their female counterparts, widening the gap from 16% in 2000. Such pay gap is of more concern given that both genders go through the same training and take similar risks. Gap in leadership positions- Gender gap is more prevalent in leadership roles. | The finding that men aspire more to surgery specialties and women prefer more often general practice and nonsurgery specialties is consistent with previous research . However, the significance of gender influence, stating the higher aspirations of women for general practice is not very strong (see table 4, Model 1: p = 0.046). In separate analyses of different stages of education this gender influence even disappeared. | [3.0, 2.0, 3.0, 2.0, 2.0] | Medicine | train | 2.4 | news | http://ct.moreover.com/?a=37759049921&p=1pl&v=1&x=RXeUx8pnfSV9zoQ5zjpYTQ |
10.1111/add.14393 | Medicine_511 | "We know these harm reduction strategies are effective in preventing hepatitis C. We must improve our efforts to enhance strategies to prevent hepatitis C infection and reduce the number of new infections." | The HCV viraemic prevalence was 60-80% in 10 countries, 40-< 60% in 38 countries and < 40% in 50 countries. | While this only represents 8.5 percent of all infections, there is a considerable further burden among people with a history of injecting drug use. "We know these harm reduction strategies are effective in preventing hepatitis C. We must improve our efforts to enhance strategies to prevent hepatitis C infection and reduce the number of new infections." The new research reveals that the greatest numbers of people with hepatitis C who have recently injected drugs live in Eastern Europe, East and Southeast Asia, and North America. | At the country level, there was very marked variation in the estimates of HCV viraemic prevalence between countries, ranging from 0.5% (UI = 0.0-1.4; Maldives) to 72.8% (UI = 68.8-76.7; Mauritius) ( Fig. The HCV viraemic prevalence was 60-80% in 10 countries, 40-< 60% in 38 countries and < 40% in 50 countries. The largest populations of people with recent injecting drug use living with HCV infection were in Russia (969 500; UI = 463 000-1 570 500), the United States (895 000; UI = 353 500-1 601 500), China (828 000; UI = 493 000-1 228 500) and Brazil (461 000, UI = 336 500-596 500) ( Fig. | [3.0, 3.0, 1.0, 1.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=34614481283&p=1pl&v=1&x=l9r6ZsooGbwi-xiv6r37nA |
10.1089/trgh.2018.0014 | Medicine_512 | This process revealed that, in this study sample, more time passed after undergoing gender-affirming surgery was associated with a lower likelihood of seeking mental health treatment. | Moreover, the DSM-5 clearly points to the existence of gender diverse populations who do not experience distress or impairment, prevalence studies then do not contribute to the validity of any tools determining GD. | Less than one-third received neither treatment. This process revealed that, in this study sample, more time passed after undergoing gender-affirming surgery was associated with a lower likelihood of seeking mental health treatment. That suggests that gender-affirming surgery boosts mental health over time, more so than hormone treatment or no treatment at all. | Moreover, if the intention of research is to understand links between biology and gender identity, it is methodologically weak to attempt to do so by looking solely at clinically referred populations for whom gender diversity is causing distress or impairment. Moreover, the DSM-5 clearly points to the existence of gender diverse populations who do not experience distress or impairment, prevalence studies then do not contribute to the validity of any tools determining GD. A large majority of articles did not make it clear whether ''clinically significant distress'' or social impairment had been established, or even assessed by a clinician or the researcher. | [3.0, 1.0, 3.0, 1.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=40344614896&p=1pl&v=1&x=KM56ohmnQ-bIRGluHw3gKQ |
10.1073/pnas.1409860111 | Medicine_513 | Accurate or not, first impressions appear to stem from how a person looks. | First (Fig. | Accurate or not, first impressions appear to stem from how a person looks. Even though it is not clear how accurate they are, these first impressions can influence our subsequent behavior (for example, judgments of competence based on facial images can predict election results). By combining these measures the model could explain more than half of the variation in human raters' social judgments of the same faces. | Note that our analysis suggests that social trait judgments are determined by multiple small contributions from different physical attributes, which means that it is impossible to unambiguously determine the contribution of each attribute (multicollinearity), although the correlations may serve to indicate relationships worthy of further investigation. First (Fig. Then (Fig. | [1.0, 2.0, 1.0, 2.0, 1.0] | Medicine | train | 1.4 | news | http://psychcentral.com/news/2014/07/29/facial-features-provide-first-impression/73005.html |
10.1038/s41562-018-0366-8 | Medicine_514 | And by providing evidence of the role of memory destabilization and reconsolidation in visual perceptual learning, the researchers offer insights into how the brain learns and refines new skills, keeping humans able to adapt in a changing world. | The similarity in the time-course changes in the E/I ratio and behavioural performance between reconsolidation and consolidation is in accordance with the hypothesis that these two processes have similar or some common underlying mechanisms. | "This may explain why practice makes your skill and memory better, if you consider practice as a series of reactivations, increasing the level of plasticity again and again," Sasaki said. By showing that visual brain areas are highly excitable following memory reactivation, Sasaki and her colleagues shed light on how new information is incorporated into the memory. And by providing evidence of the role of memory destabilization and reconsolidation in visual perceptual learning, the researchers offer insights into how the brain learns and refines new skills, keeping humans able to adapt in a changing world. | First, although it has been controversial whether reactivation and reconsolidation of skill learning occurs in humans, our results show that reactivation and reconsolidation indeed occur in humans with VPL, a type of procedural learning. The similarity in the time-course changes in the E/I ratio and behavioural performance between reconsolidation and consolidation is in accordance with the hypothesis that these two processes have similar or some common underlying mechanisms. Thus, the E/I ratio decreases from high after the end of training or reactivation to baseline levels 3.5 hour later, thereby reflecting that both consolidation and reconsolidation are associated with decreases in the degree of plasticity. | [3.0, 3.0, 1.0, 2.0, 1.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=34502600282&p=1pl&v=1&x=LB8CER237X2pdI0qQt-rJg |
10.1093/aje/kwu128 | Medicine_515 | The compound result of both effects is that total mortality rises in expansions and falls in recessions." | An increased hazard of death for nonwhites (for instance, by 26%; hazard ratio = 1.26 in model M1, Table 1 ) is observed across models (Tables 2-4 ), but the increase in the hazard, though always significant, ranges widely from 25% (Table 1, model M3) to 72% (Table 3, model M1LE) . | Compared with the increase in the risk of death among the unemployed, the decrease of the mortality risk associated with a weakening economy is small, but the benefit spreads across the entire adult population. The compound result of both effects is that total mortality rises in expansions and falls in recessions." While this investigation did not cover the potential causes for these phenomena, the authors suggest that the increase in the risk of death associated with individual joblessness may be related to stress and depression, which often lead to substance abuse and other harmful behaviors. | Females have a significantly lower hazard of death. An increased hazard of death for nonwhites (for instance, by 26%; hazard ratio = 1.26 in model M1, Table 1 ) is observed across models (Tables 2-4 ), but the increase in the hazard, though always significant, ranges widely from 25% (Table 1, model M3) to 72% (Table 3, model M1LE) . Compared with nonmarried persons, married persons have a significantly reduced hazard of death-for instance, by 36% (i.e., 1 − 0.64 = 0.36) in model M1 (Table 1) . | [5.0, 3.0, 2.0, 2.0] | Medicine | train | 2 | news | http://www.healthcanal.com/public-health-safety/53473-losing-your-job-could-kill-you-but-recessions-could-be-good-for-your-health.html |
10.1177/0956797614534694 | Medicine_516 | But it turns out the impact of sleeplessness goes deeper than a double espresso or two can solve. | Planned comparisons revealed that in the morning-encoding condition, the false memory rate was significantly higher in the sleep-deprived group than in the rested group, t(51) = 2.01, p = .04 (two-tailed), Cohen's d = 0.56. | Anyone who's succumbed to a late-night Netflix marathon, only to stumble into work at 8 a.m. the next day, will vouch for the effect a lack of sleep can have on your brain function. But it turns out the impact of sleeplessness goes deeper than a double espresso or two can solve. That might be problematic enough if you're working in an office, for example, and you lose your focus after the phone rings. | However, there was a significant interaction between the factors, F(1, 99) = 4.52, p = .04. Planned comparisons revealed that in the morning-encoding condition, the false memory rate was significantly higher in the sleep-deprived group than in the rested group, t(51) = 2.01, p = .04 (two-tailed), Cohen's d = 0.56. However, in the evening-encoding condition, there was no significant difference in the false memory rate between sleep-deprived and rested participants, t(52) = 0.98, p = .33 (Fig. | [3.0, 2.0, 2.0, 2.0, 1.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=37283282830&p=1pl&v=1&x=IqAMjFQanJyiIcdckYqgcw |
10.1017/ice.2014.2 | Medicine_517 | Risk for person-to-person transmission in A H7N9 is lower compared to other viruses including certain influenza strains, but some cases were identified as being spread between relatives. | Hand hygiene compliance demonstrated an increase in all clinical departments from 23% (2007 baseline) to 66% (2010) and to 75% (2013). | "Despite the delay in airborne precaution implementation, we suspect that high hand hygiene compliance, as a result of continuous implementation of proactive control measures against various viruses and multidrug-resistant organisms, protected frontline healthcare workers against many challenges of emerging infectious diseases." Risk for person-to-person transmission in A H7N9 is lower compared to other viruses including certain influenza strains, but some cases were identified as being spread between relatives. During the study period, 126 of 163,456 admitted patients were tested for the strain and two cases tested positive for A H7N9 influenza. | The pathogenicity of influenza A H7N9 appeared to be lower than that of HN1, but the former was capable of replicating in the upper and lower respiratory tract. Hand hygiene compliance demonstrated an increase in all clinical departments from 23% (2007 baseline) to 66% (2010) and to 75% (2013). The first case of influenza A H7N9 was in a 36-year-old Indonesian woman. | [1.0, 1.0, 1.0, 1.0, 2.0] | Medicine | train | 1.2 | news | http://www.healthcanal.com/infections/58819-infection-control-preparedness-measures-control-avian-flu-in-hong-kong-hospital.html |
10.1002/cbic.201300796 | Medicine_518 | The new system, described in the March 21st issue of journal ChemBioChem, could have a major impact on peptide drug development, says Bradley Pentelute, an assistant professor of chemistry and leader of the research team. | During our studies with ACP(65-74), we observed no decrease in the Val deletion peptide after double coupling Val and double deprotecting the preceding Gln, and these results are consistent with our experience optimizing the fragments of B. a. RNAse and the DARPin. | The new system, described in the March 21st issue of journal ChemBioChem, could have a major impact on peptide drug development, says Bradley Pentelute, an assistant professor of chemistry and leader of the research team. "Because you can get these really fast now, you can start to do things you couldn't do before." Using this approach, each amino acid addition takes only a few minutes, and an entire peptide can be assembled in little more than an hour. | Fourth, high quality peptides can be obtained quickly without double coupling, double deprotection, or colorimetric tests of coupling efficiency. During our studies with ACP(65-74), we observed no decrease in the Val deletion peptide after double coupling Val and double deprotecting the preceding Gln, and these results are consistent with our experience optimizing the fragments of B. a. RNAse and the DARPin. Finally, automation of this system enables faster cycle times, in contrast to the often slow automation of batch synthesis. | [1.0, 1.0, 2.0, 2.0, 1.0] | Medicine | train | 1.4 | news | http://www.sciencedaily.com/releases/2014/03/140319085543.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1146/annurev.psych.60.110707.163514 | Medicine_519 | Rosenbaum, who was not a part of this research, tells Inverse that this study adds to a growing realization that gorilla social structures are more complex than we previously realized. | It draws on many of the same brain structures involved in perception, cognition, and behavior more generally, but specialization may be evident at the level of neural processing as well (see sidebar Face Processing and Modularity). | From the lens of human experience, it would be easy (and likely accurate) to call the latter group friends. Rosenbaum, who was not a part of this research, tells Inverse that this study adds to a growing realization that gorilla social structures are more complex than we previously realized. "It would almost be more surprising if these were simply random interactions." | Although many open questions remain, several of them linked to technical issues in measurement and analysis (see sidebar Future Challenges), it seems clear that human social cognition is both special and ubiquitous. It draws on many of the same brain structures involved in perception, cognition, and behavior more generally, but specialization may be evident at the level of neural processing as well (see sidebar Face Processing and Modularity). Three prominent differences discussed above are: the ability to shift one's conscious experience to places and times outside the here-and-now, and into the viewpoint of another mind (Buckner & Carroll 2006 ; the association of our evaluation of others with strong moral emotions that motivate particular aspects of social behavior, such as altruistic punishment (Fehr & Gaechter 2002) ; and the ability to use these abilities flexibly as a function of context, across considerable time intervals, and with the | [2.0, 1.0, 1.0, 2.0, 4.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=39734684164&p=1pl&v=1&x=0ozGmWfzlQQwnUcL442DSg |
10.1038/s41598-018-29793-w | Medicine_52 | Each nasal microbiota type had a characteristic inflammatory response and viral load profile. | The results indicate that nasal microbiota has a role in the presentation of viral upper respiratory illness symptoms. | The study team found that the baseline nasal microbiota samples divided into six types named after predominant bacterial genera: (1) Staphylococcus, (2) Corynebacterium/Alloiococcus, (3) Moraxella, (4) Haemophilus, (5) Pseudomonadaceae/Mixed, and (6) Mixed. Each nasal microbiota type had a characteristic inflammatory response and viral load profile. In general, subjects having Staphyloccocus, and Corynebacterium/Alloiococcus types had lower inflammatory responses and Pseudomonadaceae/Mixed type had lower viral load than other types. | The individual symptoms sneezing, plugged nose, and cough followed a similar pattern. The results indicate that nasal microbiota has a role in the presentation of viral upper respiratory illness symptoms. It has been shown that the severity of illness is modestly correlated with the innate inflammatory CXCL8 and CXCL10 response to the virus 33 , however the nasal lavage concentrations of these cytokines were similar between the clusters. | [5.0, 4.0, 3.0, 2.0, 4.0] | Medicine | train | 3.6 | news | http://ct.moreover.com/?a=37212363335&p=1pl&v=1&x=sLcdfRtU-o1Jl6n2DiKDzQ |
10.1073/pnas.1422096112 | Medicine_520 | "Defining biomarkers like this epigenetic tag associated with the oxytocin receptor may help us to predict future social developmental problems and inform interventions for those with social deficits," said co-author Jessica J. Connelly, a U.Va. | Analyses using a left amygdala seed region revealed no significant voxels. | assistant professor of psychology, individuals with lower DNA methylation show diminished brain response to angry and fearful faces and greater communication between brain regions important for regulating emotion. "Defining biomarkers like this epigenetic tag associated with the oxytocin receptor may help us to predict future social developmental problems and inform interventions for those with social deficits," said co-author Jessica J. Connelly, a U.Va. "While our findings certainly have clinical implications, we show that even in a healthy population these markers are variable and may partially explain what makes each of us unique in how we respond in social situations," said the study's lead author Meghan Puglia, a Ph.D. candidate in psychology at U.Va. | S6 and S7) identified similar regions with the same pattern of activation. Analyses using a left amygdala seed region revealed no significant voxels. Using an imaging epigenetic approach, we provide evidence that a functional epigenetic modification within OXTR predicts individual variability in neural response to negative social stimuli. | [1.0, 1.0, 2.0, 1.0, 1.0] | Medicine | train | 1.2 | news | http://www.newswise.com/articles/u-va-team-finds-molecular-tag-that-explains-differences-in-brain-s-response-to-anger-fear |
10.1073/pnas.1410186112 | Medicine_521 | But McIntyre said some of the findings were not entirely expected. | In the Sierra Nevada, increases of small trees of 63% and declines of large trees of 20% were found in resurveyed plots . | There is indeed a general pattern across the entire state: large trees are in decline, and even though they are known to suffer disproportionate mortality rates in times of drought, the report describes the decline as "striking." But McIntyre said some of the findings were not entirely expected. "What was somewhat surprising is that we detected a signal that the steepest declines in large trees were in areas where our models suggest that water stress for plants has increased the most. | The differences in forest structure between the contemporary and historical datasets are also consistent with results of smaller studies that attempted to relocate and resurvey VTM plots. In the Sierra Nevada, increases of small trees of 63% and declines of large trees of 20% were found in resurveyed plots . Similarly, a 79% increase in tree density was found in the Transverse ranges of southern California, attributed to fire suppression . | [1.0, 2.0, 1.0, 1.0, 4.0] | Medicine | train | 1.8 | news | http://www.theepochtimes.com/n3/1211310-changing-california-forests-may-help-us-prepare-for-the-future/ |
10.1037/a0014755 | Medicine_522 | If anything, I think this is advice for parents of boys, to make sure that their boys have female friends growing up. | An important topic for future studies will be to further examine factors that lead to changes in suppression, including both features of the environment that may affect all individuals similarly and construal processes that may vary from one individual to the next. | Be friends with women, and that should really start when you're kids. If anything, I think this is advice for parents of boys, to make sure that their boys have female friends growing up. And once you have the groundwork for thinking of girls as equals, you can't just shift that." | Variance in the dynamic component of suppression may reflect differences in how the transition was construed-as a traumatic separation by some and as an exciting social opportunity by others. An important topic for future studies will be to further examine factors that lead to changes in suppression, including both features of the environment that may affect all individuals similarly and construal processes that may vary from one individual to the next. Although we did not reassess suppression at the end of the fall term, indirect evidence suggests that changes in suppression may have endured. | [2.0, 2.0, 2.0, 3.0, 3.0] | Medicine | train | 2.4 | news | http://ct.moreover.com/?a=37631861006&p=1pl&v=1&x=MfBpuiejaIC9ZaCTBUlhMg |
10.1016/j.biopsych.2010.02.005 | Medicine_523 | That's a lot to choose from. | Pearson correlations indicated that OT was unrelated to demographic variables, including parent age, height, weight, smoking, use of medications, and time of last meal. | That's a lot to choose from. After the vole study, interest in the nine-amino acid peptide started to rise. It is not all marketing and placebos, however. | Figure 1 illustrates frequency distributions of OT levels in mothers and fathers during the first and second visits. Pearson correlations indicated that OT was unrelated to demographic variables, including parent age, height, weight, smoking, use of medications, and time of last meal. In addition, maternal OT was not related to menstrual cycle phase, contra- ceptive intake, mode of delivery (vaginal vs. caesarean section), feeding style (breastfeeding vs. bottle feeding), postpartum interval (weeks from birth to date of blood draw), or the interval from prior breastfeeding. | [3.0, 1.0, 3.0, 1.0, 1.0] | Medicine | train | 1.8 | news | http://www.scientificamerican.com/article/fact-or-fiction-oxytocin-is-the-love-hormone/ |
10.1126/scitranslmed.aaw2064 | Medicine_527 | Although the work is still at an early stage, the findings open a "realistic path" that tests the links between pre-existing active lifestyle and subsequent recovery from a spinal injury, and possibly paves the way for clinical trials in human patients, say researchers at Imperial College London, led by the Dr. Simone Di Giovanni. | Parameters that correlated with improved recovery included reduced paw dragging, increased step height, and more frequent plantar steps with weight bearing (Fig. | This finding explains why people who have led an "active lifestyle" recover more after spinal cord injury than those with "less active" lifestyles. Although the work is still at an early stage, the findings open a "realistic path" that tests the links between pre-existing active lifestyle and subsequent recovery from a spinal injury, and possibly paves the way for clinical trials in human patients, say researchers at Imperial College London, led by the Dr. Simone Di Giovanni. "We have shown that environmental enrichment, how housing the mice in a larger cage than usual, with other mice, with more toys, tunnels, swings, wheels, etc., increases the activity of the neurons. | PC1 captured the extent of the recovery, showing that CSP-TTK21 significantly (P = 0.0002) improved locomotor performance compared to CSPtreated rats. Parameters that correlated with improved recovery included reduced paw dragging, increased step height, and more frequent plantar steps with weight bearing (Fig. The number of footfalls occurring during locomotion across a horizontal ladder also decreased ( fig. | [3.0, 1.0, 1.0, 2.0, 3.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=38965485737&p=1pl&v=1&x=YmKptu5RU9Zpxjvh34QP3Q |
10.1093/asj/sjw089 | Medicine_528 | However, a bazooka is not self-navigating. | This 49-year-old man is a poor candidate for leg hair extraction because of complete hair loss in most areas. | With the Dr.UGraft Revolution Console and Nurture handpiece, the wait is finally over. However, a bazooka is not self-navigating. I prefer the term Tomahawk which is a self-guiding missile." | The author has observed that following scoring by the UPunch Rotor, a variable percentage of grafts is completely Figure 3 . This 49-year-old man is a poor candidate for leg hair extraction because of complete hair loss in most areas. In the areas with hair, the hair is also vellous-looking with densities below 8 per cm 2 . | [1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37347525609&p=1pl&v=1&x=3KFR7iLlfn28dZzIHuWgYQ |
10.1063/1.4913758 | Medicine_529 | The team's research sets up a framework by which future hillslope-soil models can be analyzed to predict the worst possible rain pattern that could lead the hillslope to flood, Curtu noted. | In fact, during this day the percentage of users tweeting from Venezuela (≈ 20%) was very low in comparison to the rest of the days (average around > 80%). | "In this case, by using physical parameters to describe a realistic hillslope, we found a pattern of precipitation that yields the greatest -- most amplified -- runoff coefficient, which determines the manner and how fast water will reach the river link." The team's research sets up a framework by which future hillslope-soil models can be analyzed to predict the worst possible rain pattern that could lead the hillslope to flood, Curtu noted. This can be used to predict the extent of flooding possibilities based on predicted rain patterns. | Besides a large amount of users from all around the globe joined to the conversation, making the topic international, rather than local from Venezuela. In fact, during this day the percentage of users tweeting from Venezuela (≈ 20%) was very low in comparison to the rest of the days (average around > 80%). Hence, our set of Venezuelan elite were not capable of polarizing this majority of worldwide users. | [1.0, 2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.2 | news | http://www.sciencedaily.com/releases/2015/03/150310123111.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1038/s41598-018-25573-8 | Medicine_53 | These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer." | Lastly, a tumor could be established in the egg using tumor samples from ovarian cancer patients and that our nanoparticles were effective in eliminating the tumor. | Lastly, a tumor could be established in the egg using tumor samples from ovarian cancer patients and that our nanoparticles were effective in eliminating the tumor. These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer." "We were surprised when the tumor was formed in three days," notes Dr. Tamanoi. | Furthermore, we observed excellent tumor accumulation of the nanoparticles. Lastly, a tumor could be established in the egg using tumor samples from ovarian cancer patients and that our nanoparticles were effective in eliminating the tumor. These results point to the remarkable efficacy of our nanoparticle based drug delivery system and suggests the value of the chicken egg tumor model for testing novel therapies for ovarian cancer. | [4.0, 4.0, 2.0, 3.0, 5.0] | Medicine | train | 3.6 | news | http://ct.moreover.com/?a=34218407527&p=1pl&v=1&x=TZ9cA3HHZNB3jHckRRSErA |
10.1038/s41598-017-08692-6 | Medicine_530 | Younger children (between 3-5 years old) preferred a more equal distribution of money, and older players, i.e., adolescents and young adults, were more prone to consider the other participants' intentions. | Another important aspect of our approach is the use of meta-analytic decoding. | Younger children usually prefer egalitarian outcomes, whereas older children and adolescents consider reciprocity and intention. Younger children (between 3-5 years old) preferred a more equal distribution of money, and older players, i.e., adolescents and young adults, were more prone to consider the other participants' intentions. The scientists found that this development of intention-based reciprocity was significantly correlated with the decrease in the cortical thickness of the social brain in late adolescence, specifically the MPFC. | The shift from egalitarianism to intention-based reciprocity was statistically mediated by cortical thinning in the DMPFC and posterior temporal lobe that are known to be involved in processing social information 4, 12, 28-30, 32, 37- 47, 52-56 . Another important aspect of our approach is the use of meta-analytic decoding. We found that the social inference topic was the most spatially consistent with our results among 41 topics that covered a broad range of cognitive processes. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=40322312938&p=1pl&v=1&x=8J0o0AiJ6oUGKUZ8i-_wpQ |
10.1038/s41467-018-03725-8 | Medicine_531 | With the help of oncology collaborators at the ONJCRI, the researchers demonstrated that the diagnostic approach could be easily translated to the clinic. | In Supplementary Fig. | "These nanoparticles emit a unique barcoded signal when hit with laser light, and this signal changes ever so slightly if that nanoparticle encounters a CTC and sticks to it, making them easy to detect." With the help of oncology collaborators at the ONJCRI, the researchers demonstrated that the diagnostic approach could be easily translated to the clinic. The technology successfully tracked in real-time how the diversity of tumour cell populations were changing in response to particular therapies for all of the patients studied, and was highly predictive of treatment effectiveness and patient outcomes. | 7 , each antibody-SERS label alone and in combination enable the detection down to 10 cells, demonstrating that our technique is sensitive for cell characterisation. In Supplementary Fig. 8 , Raman intensities showed a positive correlation with increasing cell numbers, and a detection limit of 10 cells was distinguished from the blank PBS signal. | [1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=33835182104&p=1pl&v=1&x=mvlcc2nMKjTf7fD7xDthOQ |
10.1016/j.cell.2015.10.069 | Medicine_532 | Dr Giulia Rancati, Principal Investigator at IMB and corresponding author of the paper, said, aEURoeWe are thrilled to challenge a longstanding paradigm in genetics, especially one with such clinical implications. | In particular, evolvable genes were enriched for components of subcellular compartments found only in eukaryotes (nucleus, endoplasmic reticulum, Golgi apparatus), but lacked core machineries common to all known cellular systems (mediators of DNA, mRNA and protein synthesis). | With this new paradigm, drug resistance can be predicted at the discovery stage and resources can be optimised to develop more effective drugs that can save lives. Dr Giulia Rancati, Principal Investigator at IMB and corresponding author of the paper, said, aEURoeWe are thrilled to challenge a longstanding paradigm in genetics, especially one with such clinical implications. The next step will be to translate these findings in pathogenic fungi and human cells, and to find non-evolvable essential genes as novel antifungal and chemotherapy targets, respectively.aEUR
Professor Rong Li, Bloomberg Distinguished Professor of Cell Biology and Chemical Biomolecular Engineering at Johns Hopkins University (JHU), and a world renowned expert in cellular asymmetry, division and evolution commented, aEURoeThis is a fantastic study that takes a systematic approach to re-define the essentiality of gene function, taking into account the cellaEUR(tm)s adaptive potential. | Our data also pointed toward specific cellular functions being more evolvable than others. In particular, evolvable genes were enriched for components of subcellular compartments found only in eukaryotes (nucleus, endoplasmic reticulum, Golgi apparatus), but lacked core machineries common to all known cellular systems (mediators of DNA, mRNA and protein synthesis). This finding might imply that while some core functions are so central to cell survival as to prevent major evolutionary changes, it is possible that evolutionarily ''younger'' essential genes might have retained a certain degree of evolvability. | [1.0, 2.0, 1.0, 2.0, 3.0] | Medicine | train | 1.8 | news | http://healthmedicinet.com/news/scientists-identify-new-paradigm-in-genetics-paving-way-for-development-of-better-drug-targets-to-save-lives/ |
10.1111/risa.12765 | Medicine_533 | It's also relatively cheap compared to space missions, and can help scientists develop new tools for looking into space. | led to an estimated $70 bn cost from lost revenue and satellite replacement for a 1859-calibre superstorm. | To observe the Sun safely and study the corona during an eclipse, you need the special filters in a spectrometer. Scientists could reconstruct the corona's magnetic field, plasma and other features to finally make sense of this extreme and mysterious environment--and help prepare Earth for its mood swings. It's also relatively cheap compared to space missions, and can help scientists develop new tools for looking into space. | It is likely that many encountered problems remain undisclosed due to commercial and security sensitivities. led to an estimated $70 bn cost from lost revenue and satellite replacement for a 1859-calibre superstorm. The failure of Intelsat's Galaxy-15 spacecraft in April 2010, probably due to space weather, provides a useful case study. | [5.0, 2.0, 1.0, 2.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39594914538&p=1pl&v=1&x=_k2NW0gkLrFN84At_6MBdw |
10.1073/pnas.1204651110 | Medicine_534 | "In effect, the same climate phenomenon that helped form hurricanes Katrina and Rita along U.S. southern coasts in 2005 also likely caused the severe drought in southwest Amazonia," Saatchi said in a statement. | We found no in situ observations over the region affected by the 2005 drought that could be used to directly verify our results. | The implications of this assessment are important because large-scale droughts can lead to sustained releases of carbon dioxide from decaying wood. "In effect, the same climate phenomenon that helped form hurricanes Katrina and Rita along U.S. southern coasts in 2005 also likely caused the severe drought in southwest Amazonia," Saatchi said in a statement. "An extreme climate event caused the drought, which subsequently damaged the Amazonian trees." | The delayed recovery of QSCAT in southwestern Amazonia suggests a decline in more long-lived aspects of canopy structure with recovery timescales greater than 3-4 y, such as loss of leaves or dieback of branches, or potential tree falls creating large gaps. We found no in situ observations over the region affected by the 2005 drought that could be used to directly verify our results. The effects of extreme droughts on the understory light environment of tropical forests may be compared with the effects of tree-fall gaps, although on much larger scales (27) . | [4.0, 4.0, 3.0, 2.0] | Medicine | train | 3.25 | news | http://www.redorbit.com/news/science/1112766449/climate-change-threat-amazon-rainforest-011813/ |
10.1016/j.stemcr.2019.01.012 | Medicine_535 | This double fail-safe approach, published online ahead of the March 5 issue of Stem Cell Reports, addresses the limitations of PSC-derived beta cells and opens the door to creating safe cell-replacement therapies for people living with T1D. | In contrast, lH1 cells selected with GCV and CB1954 exhibit a stronger (normalized by DNA content) response than the parental line ( Figure 3B, right panel) , in all likelihood reflecting the corresponding enrichment in b cells. | This double fail-safe approach, published online ahead of the March 5 issue of Stem Cell Reports, addresses the limitations of PSC-derived beta cells and opens the door to creating safe cell-replacement therapies for people living with T1D. Looming Clinical Trials Warrant SafeguardsWith clinical trials already initiated using PSC-derived beta cell progenitors and newer approaches with functional beta-like cells on the horizon, the need to ensure patient safety is of paramount importance. Their results demonstrated the removal of all unwanted cells. | Perifused non-treated, differentiated lH1 cells exhibited a glucose-responsive insulin secretion pattern similar to that of differentiated H1 ( Figure 3B , left panel). In contrast, lH1 cells selected with GCV and CB1954 exhibit a stronger (normalized by DNA content) response than the parental line ( Figure 3B, right panel) , in all likelihood reflecting the corresponding enrichment in b cells. The perifusion response of four human islet preparations is shown for comparison in Figure S6 . | [2.0, 1.0, 3.0, 1.0, 3.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=38582104092&p=1pl&v=1&x=6Ba0bRLrUqzjxGbKPej1Gg |
10.1016/j.jrp.2009.03.004 | Medicine_536 | Employers should be teaching with their employees about the importance of likability and relationship building. | Similarity of achievement potential (e.g., competitiveness) and intellectual and interest modes (e.g., flexibility and general interests) were less important. | The need to be liked is a fundamentally human one. Employers should be teaching with their employees about the importance of likability and relationship building. Employees should recognize the other person's experience, learn, listen, and validate it. | Similarity of two personality dimensions predicted relationship satisfaction and whether the pair would live together the following year: interpersonal adequacy (e.g., leadership, poise, and general social skills) and, to a lesser extent, character (e.g., maturity, responsibility, and general reliability). Similarity of achievement potential (e.g., competitiveness) and intellectual and interest modes (e.g., flexibility and general interests) were less important. Results suggested that similarity of conscientiousness, but no other big five personality trait, significantly predicted relationship quality after 15 weeks. | [1.0, 3.0, 4.0, 1.0, 3.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=40313783468&p=1pl&v=1&x=SKbYsxu6uxyzE7ymnmeu9Q |
10.1016/j.cub.2014.03.011 | Medicine_537 | "These species are irreplaceable. | However, with narrow-ranged species concentrating their ED over a small area, parts of the phylogeny are potentially, and precariously, represented only in restricted areas of the world. | By using this as a measure, conservationists can focus their attention on saving species whose loss would serve as the greatest blow to species diversity and the history of evolution. "These species are irreplaceable. If they are driven to extinction, millions of years or evolutionary history goes with them." | We noted above that in birds, high-ED species per se are not geographically more restricted than lower-ED species, which means that they are unlikely to be threatened by shrinking or shifting habitats alone. However, with narrow-ranged species concentrating their ED over a small area, parts of the phylogeny are potentially, and precariously, represented only in restricted areas of the world. Indeed, global change is expected to induce both rapid range extensions and range losses in species, often quite independent of current formal threat categorizations , with direct consequences for the spatial concentration and thus potential for global loss of evolutionary information. | [4.0, 3.0, 1.0, 4.0, 5.0] | Medicine | train | 4 | news | http://www.natureworldnews.com/articles/6595/20140411/words-top-100-most-unique-and-endangered-birds-defined-in-new-study.htm |
10.1126/sciadv.aau2477 | Medicine_538 | Almost 26 cubic kilometers of floodwater was temporarily stored on land, evaporating (or transpiring through plant leaves) much more slowly at about one cubic kilometer per day. | Inversion of these data shows that a third of Harvey's total stormwater was captured on land (25.7 ± .0 km ), indicating that the rest drained rapidly into the ocean at a rate of 8.2 km | That's far more water than was captured by stations measuring river flow, showing that much of the water either did not drain through major channels or entered those channels downstream of the last measuring station. Almost 26 cubic kilometers of floodwater was temporarily stored on land, evaporating (or transpiring through plant leaves) much more slowly at about one cubic kilometer per day. It took five weeks for the GPS measurements to return to their pre-Harvey state, bouncing back as the land was relieved of the excess water's weight. | Water left in Harvey's wake should cause elastic loading and subsidence of Earth's crust, and uplift as it drains into the ocean and evaporates. Inversion of these data shows that a third of Harvey's total stormwater was captured on land (25.7 ± .0 km ), indicating that the rest drained rapidly into the ocean at a rate of 8.2 km Over a period of 7 days, Harvey produced record-breaking rainfall, with 1.54 m of precipitation measured southeast of Houston, causing extensive flooding and $125 billion in damage, an amount second only to Hurricane Katrina . | [4.0, 4.0, 2.0, 4.0] | Medicine | train | 3.5 | news | http://ct.moreover.com/?a=37162222017&p=1pl&v=1&x=z5_0Kp-tV0-CvrEXDLiG_A |
10.1093/geronb/gbv101 | Medicine_539 | All of the people in the study reported that they thought they looked around 10 years younger than they actually were. | Taken together, we predict that when a significant relationship exists between daily stressors and subjective age, it will be mediated by positive affect, personal control, and negative affect. | "We found they seemed to be less perturbed by everyday stress," says Bellingtier. All of the people in the study reported that they thought they looked around 10 years younger than they actually were. But on stressful days, those who had undergone major stress in the past thought they looked 20 years younger while people who hadn't experienced a major change were more likely to say they looked their actual age. | We further suspect that on a daily level, individuals' subjective age may be influenced by negative affect. Taken together, we predict that when a significant relationship exists between daily stressors and subjective age, it will be mediated by positive affect, personal control, and negative affect. Nearly all participants reported their employment status as retired (n = 41). | [3.0, 3.0, 3.0, 3.0] | Medicine | train | 3 | news | http://time.com/4117072/major-stress-helps-you-weather-smaller-stress/ |
10.1007/s00125-014-3400-z | Medicine_54 | They conclude: "This nationwide retrospective cohort study found a positive correlation of type 1 diabetes with EV infection. | The findings suggest that a vaccination strategy against EV infection might slow the rising incidence of type 1 diabetes. | They add: "Taiwan has relatively low type 1 diabetes incidence; we believe that the marked escalation of the said incidence in recent decades can be largely attributed to the highly endemic spread of enterovirus infection in Taiwanese children, given that there has been little gene flow and genetic drift in such a short period." They conclude: "This nationwide retrospective cohort study found a positive correlation of type 1 diabetes with EV infection. Our results suggest that preventive strategies, such as an effective vaccine against EV infection, may lessen the incidence of type 1 diabetes in Taiwan." | Whilst the evidence of an association between EV infection and pathogenesis is observational, the conclusions are solid enough to guide further research on this association. The findings suggest that a vaccination strategy against EV infection might slow the rising incidence of type 1 diabetes. Duality of interest The authors declare that there is no duality of interest associated with this manuscript. | [2.0, 3.0, 3.0, 2.0] | Medicine | train | 2.5 | news | http://www.sciencedaily.com/releases/2014/10/141017183715.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1080/15560350802081314 | Medicine_540 | Alyssa relapsed, and overdosed on pills. | While an outcome study is needed, it was determined that a rigorous experimental or quasi-experimental trial would be premature before (a) understanding the nature of programs in operation and (b) assessing the feasibility of an outcome study. | But when she came back to Ohio and started school, peer pressure made it hard to remember what she learned. Alyssa relapsed, and overdosed on pills. Alyssa's experience is a common one. | By providing a frame which was deliberatively conceived by professionals and recovering students, however, the ARS membership criteria did serve as a guide for defining schools which were invited to participate. While an outcome study is needed, it was determined that a rigorous experimental or quasi-experimental trial would be premature before (a) understanding the nature of programs in operation and (b) assessing the feasibility of an outcome study. The prior projects described above and the ARS guidelines for membership set the stage for the project. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39825977404&p=1pl&v=1&x=wzJX19N-iCvOfpLz256iDQ |
10.1111/j.1360-0443.2010.02899.x | Medicine_541 | Logging only fat would yield 10.5gram; and a combo of each would yield 11.9gram of carbs and 5.25gram of fat.Sugar alcohols can raise an individual's blood sugar, albeit much lower than actual sugar, so they still need to be counted as carbs (~2kCal/gram), if tracking. | The variation in the effect of alcohol consumption on different types of stroke may be ascribed to the difference in the causes of haemorrhagic and ischaemic stroke. | (Side note: there's a trace amount of protein to completely count everything. Logging only fat would yield 10.5gram; and a combo of each would yield 11.9gram of carbs and 5.25gram of fat.Sugar alcohols can raise an individual's blood sugar, albeit much lower than actual sugar, so they still need to be counted as carbs (~2kCal/gram), if tracking. Just because something doesn't exert an insulin response does not mean it is free of calories. | According to these meta-analyses, low to moderate alcohol consumption (one to two drinks per day) seemed to have a protective effect on ischaemic stroke, and then the risk curve turned upwards. The variation in the effect of alcohol consumption on different types of stroke may be ascribed to the difference in the causes of haemorrhagic and ischaemic stroke. Consequently, a pattern of irregular heavy drinking occasions should also have the same detrimental effects as for IHD. | [1.0, 2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.2 | news | http://ct.moreover.com/?a=33869739377&p=1pl&v=1&x=2-Vfb5SGnEgGbA_1Dt6Pqw |
10.1073/pnas.1403382111 | Medicine_542 | It identifies an important component in regulation and this 'stop mechanism' may prevent complications from excessive water intake," he said. | Additionally, a distributed network of regions, including the insula, MCC, amygdala, midbrain, cerebellum, and PAG showed drinking-related activation related to the experience of unpleasantness that accompanies drinking water when already fully satiated. | "Different areas of the brain involved in emotional decision-making were activated when people drank water after becoming thirsty and when study participants followed instructions to keep drinking when no longer thirsty. It identifies an important component in regulation and this 'stop mechanism' may prevent complications from excessive water intake," he said. Denton believes the findings could be applied to other aspects of human gratification. | We propose that this cause is an inhibitory mechanism that prevents overdrinking from taking place postsatiation. Additionally, a distributed network of regions, including the insula, MCC, amygdala, midbrain, cerebellum, and PAG showed drinking-related activation related to the experience of unpleasantness that accompanies drinking water when already fully satiated. During the thirst condition, participants with the highest pleasantness ratings showed the greatest activation in the OFC and pACC. | [3.0, 2.0, 3.0, 4.0] | Medicine | train | 3 | news | http://www.theepochtimes.com/n3/593542-your-brain-knows-when-your-thirst-is-quenched/ |
10.2460/javma.242.11.1549 | Medicine_543 | Ten were found more frequently among purebred dogs, and one such disorder was more common in mixed-breeds. | Additionally, clients are willing to pursue more extensive treatment at a referral hospital. | The researchers found that the prevalence of 13 of the 24 genetic disorders was approximately the same in purebred dogs as in their mixed-breed counterparts. Ten were found more frequently among purebred dogs, and one such disorder was more common in mixed-breeds. The data also indicated that the more recently derived breeds or those breeds that shared a similar lineage were more susceptible to certain inherited disorders. | This would cause an overrepresentation of some disorders in purebred dogs. Additionally, clients are willing to pursue more extensive treatment at a referral hospital. Owners of purebred dogs are more likely to spend more on their dogs than are owners of mixed-breed dogs, which would result in a greater proportion of purebred dogs, as seen in the present study. | [1.0, 2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.2 | news | http://www.healthcanal.com/genetics-birth-defects/39146-purebred-dogs-not-always-at-higher-risk-for-genetic-disorders-study-finds.html |
10.1093/aje/kwm375 | Medicine_545 | (c) Aangeboden door Business Insider Inc Shutterstock
Als de griep neerdaalt in je huishouden, stellen we ons er al snel op in dat we zelf ook ziek zullen worden binnen niet al te lange tijd. | A total of 827 papers were selected (figure 1). | (c) Aangeboden door Business Insider Inc Shutterstock
Als de griep neerdaalt in je huishouden, stellen we ons er al snel op in dat we zelf ook ziek zullen worden binnen niet al te lange tijd. Ook als je zorgt voor een zieke partner of een grieperig kind. (c) Aangeboden door Business Insider Inc
Foto: Shutterstock
De kans dat je griep oploopt via een andere persoon, is relatief groot. | However, these percentages come from pre-and postinfluenza-season serologic studies, and they may therefore be subject to recall bias when individuals were asked whether they had had influenza-like illness during winter or to classification bias due to lack of sensitivity of laboratory tests . A total of 827 papers were selected (figure 1). Differences were resolved by discussion and consensus. | [1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37360360866&p=1pl&v=1&x=ovfeGx1RmpUVOmDW-nAgvA |
10.1098/rspb.2013.1698 | Medicine_546 | After multiple exposures to a striking visual pattern, neurons in the retina and visual cortex of the brain fire less frequently the next time you see the pattern. | The average time spent in REM was negatively correlated with SWS duration, which, in turn, can explain the negative correlation that was found for SWS duration and adaptation and for low-frequency power in the delta and theta range and adaptation. | After multiple exposures to a striking visual pattern, neurons in the retina and visual cortex of the brain fire less frequently the next time you see the pattern. By devoting less energy to familiar sights, the brain is free to concentrate on the next new thing that comes along; the original image becomes a routine perception. These nappers perceived the original faces to be compressed, whereas a group who simply wore a blindfold for 90 minutes didn't show this adaptation. | Participants who exhibited high amounts of REM sleep also showed greater adaptation. The average time spent in REM was negatively correlated with SWS duration, which, in turn, can explain the negative correlation that was found for SWS duration and adaptation and for low-frequency power in the delta and theta range and adaptation. Adaptation was further predicted by spindle density of both slow and fast spindles, however in opposite ways. | [2.0, 1.0, 2.0, 1.0, 1.0] | Medicine | train | 1.4 | news | http://news.sciencemag.org/brain-behavior/2013/08/i%E2%80%99ve-grown-accustomed-face |
10.1016/j.biopsych.2015.04.026 | Medicine_547 | This may seem counterintuitive, but Moghaddam says it makes perfect sense. | Thus, during extinction, adolescent VTA neurons maintained a strong phasic response to a cue previously predictive of reward availability. | Anticipation isn't enough
The new findings, published in the journal Biological Psychiatry, show that when adolescents are faced with the prospect of a reward, their dopamine neurons are actually activated less than in adults. This may seem counterintuitive, but Moghaddam says it makes perfect sense. Adult rats get a small dopamine rush from simply anticipating a reward, while adolescent rats don't get the same level of dopamine-based satisfaction. | In session 8, which was an entirely extinction session, adolescent cue responses were significantly greater than adults (F 1,127 5 6.430, p 5 .012; Figure 2B ). Thus, during extinction, adolescent VTA neurons maintained a strong phasic response to a cue previously predictive of reward availability. There were no age-related differences in action-or reward-evoked activity during extinction (action: F 1,127 5 2.121, p 5 .121; reward: F 1,127 5 .317, p 5 .574), indicating that other task-related events are processed similarly by both age groups during extinction. | [1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://www.futurity.org/teenagerss-risk-reward-dopamine-951052/ |
10.1038/s41467-018-05526-5 | Medicine_548 | After a few weeks, roles had redistributed in both groups! | The incomer mouse #5 switched less, whereas the resident mouse #6 switched more in step 2 compared to step 1. d Switch variation between step 1 and 2 (ΔSW) for incomers and residents (two-sample t-test, t(27) = 2.9401). | Therefore, one can say that mice have biologically inscribed individuality. After a few weeks, roles had redistributed in both groups! Some mice who had rarely varied their choice had become the more adventurous ones in their new group, and vice versa. | b Cumulative distribution of SW for steps 1 (purple) and 2 (green) (D = 0.2069, p = 0.57). The incomer mouse #5 switched less, whereas the resident mouse #6 switched more in step 2 compared to step 1. d Switch variation between step 1 and 2 (ΔSW) for incomers and residents (two-sample t-test, t(27) = 2.9401). (Right) SW is different for the same two groups after step 2 (Two-sample t-test (t = 3.5914, **p < 0.01)). | [1.0, 1.0, 3.0, 1.0, 4.0] | Medicine | train | 1 | news | https://www.sciencedaily.com/releases/2018/08/180806073138.htm |
10.1126/science.aao0432 | Medicine_549 | So, it remains to be seen if, or how, the 34-page framework will translate into actual policy changes, like more humanitarian visas for those displaced by drought or rising seas. | We show a quadratic response function (dashed brown line), as well as flexible restricted cubic splines (solid brown line). | Several EU countries joined the US and Australia in opting not to adopt the document. So, it remains to be seen if, or how, the 34-page framework will translate into actual policy changes, like more humanitarian visas for those displaced by drought or rising seas. "It is difficult to say," Gemenne said. | The coefficients on temperature are displayed in Fig. We show a quadratic response function (dashed brown line), as well as flexible restricted cubic splines (solid brown line). These models correspond to columns (1a) and (3a) of table S1, respectively. | [1.0, 2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.2 | news | http://ct.moreover.com/?a=37956093465&p=1pl&v=1&x=jt9X3KNlGqIE0laIMZIedg |
10.1007/s13524-014-0321-x | Medicine_55 | Those who become parents between the ages of 23 -34 have increasing happiness before a first birth, however one to two years after the birth, happiness decreases to baseline or below. | The OLS specification suggests that happiness increases significantly one year before the birth, stays at an elevated level in the year of birth, and then quickly returns to pre-birth levels. | Older parents, between the ages of 35 -- 49, have the strongest happiness gains around the time of birth and stay at a higher level of happiness after becoming parents. Those who become parents in their teens have a predominantly declining pattern of happiness that does not increase above the baseline even during the year of birth. Those who become parents between the ages of 23 -34 have increasing happiness before a first birth, however one to two years after the birth, happiness decreases to baseline or below. | Modeling these as time-varying would not change the results. The OLS specification suggests that happiness increases significantly one year before the birth, stays at an elevated level in the year of birth, and then quickly returns to pre-birth levels. Happiness stays at this level from when the first child is young through when the child reaches adult ages. | [2.0, 5.0, 4.0, 3.0, 3.0] | Medicine | train | 3.4 | news | http://www.sciencedaily.com/releases/2014/10/141028082454.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1073/pnas.1417259112 | Medicine_551 | Picking a needle out of a haystack might seem like the stuff of fairytales, but our brains can be electrically "tuned" to enable us to do a much better job of finding what we're looking for, even in a crowded and distracting scene, new research indicates. | Additionally, by fitting these behavioral RT data with a logarithmic function to model the rate of improvement (9), we found that anodal tDCS significantly increased the rate parameters of RT speeding (F 1,17 = 5.097, P = 0.037). | Picking a needle out of a haystack might seem like the stuff of fairytales, but our brains can be electrically "tuned" to enable us to do a much better job of finding what we're looking for, even in a crowded and distracting scene, new research indicates. The new findings, published Dec. 1, 2014, in the Proceedings of the National Academy of Science, challenge our current understanding of how visual attention is focused and the roles of short and long-term memory. "These new findings provide evidence that long-term memory representations can also underlie our ability to rapidly configure attention to focus on certain objects, and that long-term memory performance can be sharply accelerated using electrical stimulation." | This striking causal aftereffect of anodal tDCS was evidenced by a stimulation condition × target repetition interaction on RTs (F 2,34 = 3.735, P = 0.042), with this RT effect being significant between the first two trials of search for a particular Landolt C (F 1,17 = 6.204, P = 0.023) but with no significant change thereafter (P > 0.310). Additionally, by fitting these behavioral RT data with a logarithmic function to model the rate of improvement (9), we found that anodal tDCS significantly increased the rate parameters of RT speeding (F 1,17 = 5.097, P = 0.037). Consistent with the interpretation that tDCS changed how attention selected the targets in the search arrays, we found that the N2-posterior-contralateral (N2pc) component, an index of the deployment of covert attention to the possible target in a search array (26), showed a pattern that mirrored the single-trial RT effects (F 1,17 = 4.792, P = 0.043) ( Fig. | [3.0, 3.0, 2.0, 1.0, 2.0] | Medicine | train | 2.2 | news | http://www.sciencedaily.com/releases/2015/01/150114090817.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1073/pnas.1306983110 | Medicine_552 | The virtual effort is similar to performance capture filming of actors for later computer-animated visual effects for such films as "The Lord of the Rings." | We show that jellyfish exhibit a unique mechanism of passive energy recapture, which is exploited to allow them to travel 30% further each swimming cycle, thereby reducing metabolic energy demand by swimming muscles. | The computer modeled jellyfish - unlike the real gelatinous zooplankton filmed in lab settings -- allows researchers to control movements of the creature however fast they wish, and in any desired direction. The virtual effort is similar to performance capture filming of actors for later computer-animated visual effects for such films as "The Lord of the Rings." Stewart said it was "remarkably difficult" to capture the flexibility and soft edges of the jellyfish into a full, controllable computational framework versus a more rigid body such as a shark or a human swimmer whose movements can more easily be modeled because of their joints. | Results from this study also have implications for bioinspired design, where low-energy propulsion is required. We show that jellyfish exhibit a unique mechanism of passive energy recapture, which is exploited to allow them to travel 30% further each swimming cycle, thereby reducing metabolic energy demand by swimming muscles. By accounting for large interspecific differences in net metabolic rates, we demonstrate, contrary to prevailing views, that the jellyfish (Aurelia aurita) is one of the most energetically efficient propulsors on the planet, exhibiting a cost of transport (joules per kilogram per meter) lower than other metazoans. | [1.0, 1.0, 3.0, 1.0, 1.0] | Medicine | train | 1.4 | news | http://www.sciencedaily.com/releases/2013/10/131017173356.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1111/desc.12068 | Medicine_553 | The Quest to Learn public school in New York City offers a glimpse of how gaming is already transforming not just how students learn, but also what they learn. | There were few significant differences between the two control groups, suggesting that the gains associated with adaptive training are unlikely to be due to expectancy effects. | Gamestars
Testing fatigue, combined with more pervasive computer use in and out of the classroom and continued experimentation with games as learning tools, suggests that such video games will play a significant role in the future of education. The Quest to Learn public school in New York City offers a glimpse of how gaming is already transforming not just how students learn, but also what they learn. "Games are also uniquely suited to fostering the skills necessary for navigating a complex, interconnected, rapidly changing 21st century," he adds. | Children who completed adaptive training made significantly greater improvements in tests of visuo-spatial STM and verbal and visuo-spatial WM than either children who completed a non-adaptive version of training or those who received no intervention. There were few significant differences between the two control groups, suggesting that the gains associated with adaptive training are unlikely to be due to expectancy effects. This is the first double-blinded RCT study on this key group of poor learners that meets stringent criteria for intervention research (e.g. | [1.0, 1.0, 2.0, 1.0, 1.0] | Medicine | train | 1.2 | news | http://www.scientificamerican.com/article/fact-or-fiction-video-games-are-the-future-of-education/ |
10.1126/sciadv.1500045 | Medicine_554 | "With X-ray crystallography, we were able to see very beautiful patterns, which was a very exciting discovery. | 5B) , including a net bleach near 500 nm and two net positive features of excited-state absorption at~580 and 640 nm (Fig. | The crystal structure of the Au133 nanoparticle divulged many secrets. "With X-ray crystallography, we were able to see very beautiful patterns, which was a very exciting discovery. These patterns only show up when the nanoparticle size becomes big enough," Jin said. | Upon photoexcitation above the optical gap, we observe three primary transient optical features (Fig. 5B) , including a net bleach near 500 nm and two net positive features of excited-state absorption at~580 and 640 nm (Fig. The bleach at 500 nm correlates to the ground-state transition at 503 nm observed in Fig. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2015/04/150409143139.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1098/rstb.2010.0157 | Medicine_555 | Behavior can be classified as cooperative if it provides a benefit to another individual (recipient) or is beneficial to both the individual and the recipient. | At the same time, these enforcement mechanisms are key in maintaining mutual cooperation in large groups and solving CAPs. | Behavior can be classified as cooperative if it provides a benefit to another individual (recipient) or is beneficial to both the individual and the recipient. The main message of their report is that in comparison with other animals have a larger toolbox of instruments used to sustain cooperation. Helping behavior builds up a reputation and individuals, who have a good name, have more chances to get support from the others in the future. | This allows humans to engage in direct and indirect reciprocity and maintain cooperative interactions at a dyadic level between unrelated individuals. At the same time, these enforcement mechanisms are key in maintaining mutual cooperation in large groups and solving CAPs. The possibility of using language to exchange social information is probably the most important difference. | [1.0, 2.0, 3.0, 2.0, 2.0] | Medicine | train | 2 | news | http://www.technology.org/2014/04/17/specific-human-cooperation/ |
10.1073/pnas.1703958114 | Medicine_556 | What they discovered clarifies animals' feeding behavior and the science of decision-making. | It should be noted that in our model at any given time a worm may be sampling, committed to pumping, or pausing. | What they discovered clarifies animals' feeding behavior and the science of decision-making. "It's an interesting model for understanding the processes that underlie how animals decide where and when to eat," says lead author Monika Scholz, an international student research fellow with the University of Chicago's biophysical sciences program who is now at Princeton University. "For these worms, it's all about the balance between speed and accuracy." | All information gathered from previous samples is thus erased and our model does not include long-term memory or learning (see Discussion). It should be noted that in our model at any given time a worm may be sampling, committed to pumping, or pausing. However, when observing the time trace of pumping one can only discern pumping from pausing. | [2.0, 1.0, 1.0, 2.0, 1.0] | Medicine | train | 1.4 | news | http://www.futurity.org/roundworms-c-elegans-decisions-food-1518062/ |
10.1016/j.celrep.2013.07.022 | Medicine_558 | The lab's results are described in the August 29 issue of Cell Reports. | Almost all planarian muscle cells express PCGs, suggesting a dual function: contraction and control of patterning. | When part of a planarian was cut off, the muscle cells in the body wall altered which PCGs they expressed in response to the wounding. The lab's results are described in the August 29 issue of Cell Reports. Yet, these functions may also explain why muscle cells are so well suited to secrete the proteins coded for by the PCGs. | Almost all planarian muscle cells express PCGs, suggesting a dual function: contraction and control of patterning. PCG expression is dynamic in muscle cells after injury, even in the absence of neoblasts, suggesting that muscle is instructive for regeneration. We conclude that planarian regeneration involves two highly flexible systems: pluripotent neoblasts that can generate any new cell type and muscle cells that provide positional instructions for the regeneration of any body region. | [2.0, 1.0, 1.0, 2.0] | Medicine | train | 1.5 | news | http://www.sciencedaily.com/releases/2013/08/130815133105.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1038/nature24303 | Medicine_559 | The almost simultaneous detections of both gravitational waves and gamma rays from GW170817 raised hopes that this object was indeed a long-sought kilonova and observations with ESO facilities have revealed properties remarkably close to theoretical predictions. | In Fig. | This makes the source both the closest gravitational wave event detected so far and also one of the closest gamma-ray burst sources ever seen. The almost simultaneous detections of both gravitational waves and gamma rays from GW170817 raised hopes that this object was indeed a long-sought kilonova and observations with ESO facilities have revealed properties remarkably close to theoretical predictions. Following the merger of the two neutron stars, a burst of rapidly expanding radioactive heavy chemical elements left the kilonova, moving as fast as one-fifth of the speed of light. | opacities of around κ = 10 cm 2 g −1 would be likely . In Fig. 3 we show the best fits forcing κ = 10 cm 2 g −1 | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/DjjnRDYz368/ |
10.1001/jama.2014.15690 | Medicine_56 | At 5 years after randomization, the cumulative primary event rate was similar in participants in the aspirin group (2.77 percent) and those in the no aspirin group (2.96 percent). | The 5-year cumulative primary outcome event rate was not significantly different between the groups (2.77% [95% CI, 2.40%-3.20%] for aspirin vs 2.96% [95% CI, 2.58%-3.40%] for no aspirin; hazard ratio [HR], 0.94 [95% CI, 0.77-1.15]; P = .54). | The researchers found that there was no statistically significant difference between the two groups in time to the primary end point (a composite of death from cardiovascular causes, nonfatal stroke, and nonfatal heart attack). At 5 years after randomization, the cumulative primary event rate was similar in participants in the aspirin group (2.77 percent) and those in the no aspirin group (2.96 percent). Aspirin significantly reduced incidence of nonfatal heart attack and transient ischemic attack, and significantly increased the risk of extracranial hemorrhage requiring transfusion or hospitalization. | Patients with an occurrence of nonfatal stroke totaled 114 in the aspirin group and 108 in the no aspirin group; of nonfatal myocardial infarction, 20 in the aspirin group and 38 in the no aspirin group; of undefined cerebrovascular events, 3 in the aspirin group and 5 in the no aspirin group. The 5-year cumulative primary outcome event rate was not significantly different between the groups (2.77% [95% CI, 2.40%-3.20%] for aspirin vs 2.96% [95% CI, 2.58%-3.40%] for no aspirin; hazard ratio [HR], 0.94 [95% CI, 0.77-1.15]; P = .54). Aspirin significantly reduced incidence of nonfatal myocardial infarction (0.30 [95% CI, 0.19-0.47] for aspirin vs 0.58 [95% CI, 0.42-0.81] for no aspirin; HR, 0.53 [95% CI, 0.31-0.91]; P = .02) and transient ischemic attack (0.26 [95% CI, 0.16-0.42] for aspirin vs 0.49 [95% CI, 0.35-0.69] for no aspirin; HR, 0.57 [95% CI, 0.32-0.99]; P = .04), and significantly increased the risk of extracranial hemorrhage requiring transfusion or hospitalization (0.86 [95% CI, 0.67-1.11] for aspirin vs 0.51 [95% CI, 0.37-0.72] for no aspirin; HR, 1.85 [95% CI, 1.22-2.81]; P = .004). | [5.0, 5.0, 4.0, 5.0] | Medicine | train | 4.75 | news | http://www.newswise.com/articles/effect-of-once-daily-low-dose-aspirin-on-cv-death-and-other-outcomes |
10.1038/s41746-018-0033-5 | Medicine_560 | Schatz envisions everyone over 60 having a phone app that constantly records their motion. | This finding suggests use of accelerometer to assess characteristics of movement beyond only gait characteristics may improve predictive ability. | Data extracted automatically from the devices predicted falls with an average of 73.7 percent accuracy and 81.1 percent for precision, the researchers report, noting that accelerometer-based measures of gait are potentially useful in screening older women for fall risk. Schatz envisions everyone over 60 having a phone app that constantly records their motion. "I work a lot with primary care physicians, and they love this [idea], because they only see people after they start falling," Schatz said. | [] [] Greater accuracy, sensitivity, and specificity can be achieved with multiple sensors on body parts other than the waist. This finding suggests use of accelerometer to assess characteristics of movement beyond only gait characteristics may improve predictive ability. Of course, this pilot study has several limitations. | [1.0, 3.0, 5.0, 3.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34528601138&p=1pl&v=1&x=69-rKRDpo5a6UlO1u9oP6w |
10.1098/rsbl.2014.0255 | Medicine_561 | "So whatever is happening in terms of evolution of the bird population and the parasite population is most likely in the earliest stages of that process." | Similarly, D. regalis showed an extraordinarily high degree of population genetic structure among geographical islands. | "Our study empirically demonstrates an important evolutionary process in which the hawks separate into different populations, and the lice living on them do the same." "So whatever is happening in terms of evolution of the bird population and the parasite population is most likely in the earliest stages of that process." A better understanding of how parasites and their hosts coevolve has implications for biomedical sciences, according to Whiteman. | Further analysis of the genetic clusters revealed a clear correspondence with the geographical islands on which populations were sampled. Similarly, D. regalis showed an extraordinarily high degree of population genetic structure among geographical islands. AMOVA and pairwise permutation tests showed that populations of lice on each island were highly differentiated (overall F ST ¼ 0.429, p , 0.0001). | [3.0, 2.0, 1.0, 1.0] | Medicine | train | 1.75 | news | http://www.sciencedaily.com/releases/2014/08/140806173840.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1086/672271 | Medicine_562 | SHEA upholds the value and critical contributions of healthcare epidemiology to improving patient care and healthcare worker safety in all healthcare settings. | 58 To completely eliminate any risk of HIV transmission to her infant, the provider may want to consider stopping breast-feeding. | Many of the revised recommendations are intended to make the PEP regimen better tolerated, increasing the possibility that HCP complete the full regimen. As such, the updated guidelines should be distributed and made readily available to emergency physicians and other providers as needed. SHEA upholds the value and critical contributions of healthcare epidemiology to improving patient care and healthcare worker safety in all healthcare settings. | 46 The lactating healthcare provider should be counseled regarding the high risk of HIV transmission through breast milk should acute HIV infection occur (in a study in Zimbabwe, the risk of breast milk HIV transmission during the 3 months after seroconversion was 77.6 infections per 100 child-years). 58 To completely eliminate any risk of HIV transmission to her infant, the provider may want to consider stopping breast-feeding. Ultimately, lactating women with occupational exposures to HIV who will take antiretroviral medications as PEP must be counseled to weigh the risks and benefits of continued breast-feeding both while taking PEP and while being monitored for HIV seroconversion. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://www.healthcanal.com/infections/hiv-and-aids/41583-new-federal-guidelines-for-managing-occupational-exposures-to-hiv.html |
10.1126/science.1237973 | Medicine_564 | "LncRNAs, unlike proteins, really can use their genomic information -- their context, their location -- to act, to bring together targets," he says. | We found that the localization of A Xist over the whole X-chromosome looked broadly comparable to that of wild-type Xist (Fig. | He adds that the work provides one of the first direct pieces of evidence to explain what makes lncRNAs special. "LncRNAs, unlike proteins, really can use their genomic information -- their context, their location -- to act, to bring together targets," he says. "That makes them quite unique." | Together, these results suggest that the initial localization of Xist is hindered by some feature of actively transcribed genes but that Xist can eventually overcome this barrier to spread across these regions. We found that the localization of A Xist over the whole X-chromosome looked broadly comparable to that of wild-type Xist (Fig. 5C, Fig. | [1.0, 2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.2 | news | http://www.sciencedaily.com/releases/2013/07/130705212230.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.15252/embj.201488795 | Medicine_566 | That, in turn, causes more of the Alzheimer's-related protein to be produced, Golde says. | Distribution of flotillin-1, a marker for lipid rafts, was not affected (Fig 3E) . | The experiments reveal more about the mechanics of a likely relationship between stress and Alzheimer's disease. That, in turn, causes more of the Alzheimer's-related protein to be produced, Golde says. One possible solution--blocking the CRF receptor that initiates the stress-induced process that generates Alzheimer's-related proteins--didn't work. | CRF treatment altered the distribution of PS1 in cells expressing wild-type CRFR1, but in cells expressing the CRFR1 D386/IC3 mutant, the distribution of PS1 was unchanged. Distribution of flotillin-1, a marker for lipid rafts, was not affected (Fig 3E) . In multiple clonal lines, stable overexpression of wild-type CRFR1 also resulted in an increase in the PS1 in the raft fractions ( Supplementary Fig S3C and D) . | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://www.futurity.org/stress-alzheimers-disease-1007782/ |
10.1016/j.jpeds.2016.10.002 | Medicine_567 | A multidisciplinary approach, Sharp adds, also provides important safeguards when introducing food to children with little or no experience consuming food. | -, All 11 studies presented data reflecting changes in oral consumption. | This study is the first meta-analysis of all published, peer-reviewed research focusing on children receiving intensive multidisciplinary intervention at day hospital and inpatient treatment programs. A multidisciplinary approach, Sharp adds, also provides important safeguards when introducing food to children with little or no experience consuming food. In addition to providing support for multidisciplinary intervention, recommendations from the study include: 1) active participation of caregivers in the treatment process - ideally with structured training procedures to support generalization into the home; 2) a formal discharge plan that involves regular outpatient follow-up to support families in maintaining and expanding upon treatment gains; and 3) use of a behavioral approach to structure meals and address mealtime difficulties (e.g., tantrums; food refusal) that prohibit consumption. | Across studies, the number and definition of outcome measures varied (Table V; available at www.jpeds.com). -, All 11 studies presented data reflecting changes in oral consumption. Of these, 8 reported the percentage of patients weaned from enteral feeds, 6 reported the percentage of calories received by oral vs enteral feeds, and 4 reported on the volume of food consumed (eg, grams, kcal). | [1.0, 2.0, 2.0, 1.0, 2.0] | Medicine | train | 1.6 | news | http://healthmedicinet.com/news/intensive-multidisciplinary-intervention-holds-benefit-for-children-with-pediatric-feeding-disorders/ |
10.1038/nm.4296 | Medicine_568 | "This discovery is the perfect example of how we take basic science discoveries and translate them to cure diseases at Northwestern Medicine." | 1d and Supplementary Fig. | The collaborative environment at Northwestern made the discovery possible, Shilatifard said. "This work could not have been done anywhere in the world except Northwestern Medicine, because of all the scientists and physicians who have been recruited here during the past five years and how they work together to link basic scientific research to the clinic," Shilatifard said. "This discovery is the perfect example of how we take basic science discoveries and translate them to cure diseases at Northwestern Medicine." | Interestingly, upon loss of H3K27me3, these nucleosomes acquire H3K27ac, which results in the formation of H3K27M-K27ac heterotypic nucleosomes 4 ( Fig. 1d and Supplementary Fig. These observations support the increased association of acetyl-binding bromodomain proteins to H3K27M-containing nucleosomes , and they prompted us to investigate the role of these proteins in DIPG cells. | [1.0, 3.0, 1.0, 1.0, 1.0] | Medicine | train | 1.4 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/nkWRzOXqal0/ |
10.1016/j.physbeh.2009.12.026 | Medicine_569 | Hey, it beats giving into impulses every time they come up! | This agrees with work in both animal models and humans ] that show about 70-75% of drinking occurs peri-prandially. | After all, you don't have to eat healthy 100 percent of the time. Hey, it beats giving into impulses every time they come up! It's as simple as that. | Otherwise, the peaks are highly synchronous. This agrees with work in both animal models and humans ] that show about 70-75% of drinking occurs peri-prandially. The weekday versus weekend differences in ingestive episodes highlight the importance of lifestyle and social custom on this activity . | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://www.theepochtimes.com/n3/1380572-8-ways-to-combat-food-cravings/ |
10.1007/s00213-019-05253-9 | Medicine_570 | They also found that when cells were pre-treated with the lipid they were more resistant to inflammation when stimulated. | The top 20 differentially expressed genes are reported in Fig. | "This new paper helps clarify that." They also found that when cells were pre-treated with the lipid they were more resistant to inflammation when stimulated. "It seems that these bacteria we co-evolved with have a trick up their sleeve," said Lowry. | Of the 203 differentially expressed genes, 109 were downregulated in the 10(Z)-hexadecenoic acid condition, and 20% of those genes were associated with proinflammatory processes (Table S4 ). The top 20 differentially expressed genes are reported in Fig. Consistent with the ex vivo macrophage experiments measuring IL-6 protein with ELISA, the second most significantly differentially expressed transcript was IL-6 (Table S3) . | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39822828994&p=1pl&v=1&x=E6y_2l3_5RNxQtw1lkssQQ |
10.1001/jamapsychiatry.2016.2600 | Medicine_571 | The findings also could help scientists who study the genetics of autism understand how mutations in a single gene can contribute to symptoms of autism, such as problems with social and language skills and repetitive behaviors. | Of 207 patients with available ADHD data (eFigure 1 in the Supplement), 94 (45.4%; 95% CI, 38.8%-52.4%) exhibited abovethreshold ADHD scores, and, in categorical evaluation of severe ADHD symptoms (AI T score ≥65), the male to female ratio was 1:1. | "In the past, we didn't really understand the association between NF1 and autism, but now we have new insights into the problem, which will allow us to design better treatments for children with NF1 and autism." The findings also could help scientists who study the genetics of autism understand how mutations in a single gene can contribute to symptoms of autism, such as problems with social and language skills and repetitive behaviors. It is equally common in both sexes and in all ethnic groups. | However, despite this correlation, quantitative ASD and ADHD trait scores generated highly contrasting distributions ( Figure 1C ). Of 207 patients with available ADHD data (eFigure 1 in the Supplement), 94 (45.4%; 95% CI, 38.8%-52.4%) exhibited abovethreshold ADHD scores, and, in categorical evaluation of severe ADHD symptoms (AI T score ≥65), the male to female ratio was 1:1. As expected, individuals with above-threshold ADHD scores demonstrated statistically significantly higher QAT scores (mean difference, 13.70; 95% CI, 10.34-17.06) compared with those with lower ADHD trait scores; however, more than half of the patients with available ADHD data (111 [53.6%]) exhibited a QAT burden in the normal range (T score <60). | [2.0, 1.0, 1.0, 1.0] | Medicine | train | 1.25 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/SumzKyaN7os/ |
10.1001/jamapsychiatry.2017.4516 | Medicine_573 | The researchers found that compared with converted adolescent females, those in the resilient group had greater connectivity between the amygdala and orbitofrontal cortex and between the dorsolateral prefrontal cortex and frontotemporal regions. | All of the participants were post-menarche at the time of scanning (age of menarche 12.331.32 years; 6.802.52 years before the MRI scan). | Twenty were at high risk and did not develop depression (resilient), 20 were at high risk and did develop depression (converted), and 25 were at low risk with no history of psychopathology (control). The researchers found that compared with converted adolescent females, those in the resilient group had greater connectivity between the amygdala and orbitofrontal cortex and between the dorsolateral prefrontal cortex and frontotemporal regions. In the resilient group only, there was a correlation for strength of amygdala-orbitofrontal cortex connectivity with positive life events. | By shifting the focus of future research to a resiliencebased model of mental health, and by investigating characteristics of high-risk individuals who remain resilient, we may increase our understanding of how to optimize resilience to psychopathology. All of the participants were post-menarche at the time of scanning (age of menarche 12.331.32 years; 6.802.52 years before the MRI scan). Parenthetically, Tanner staging ranged from 1 to 4.5 (3.201.10; average of breast and hair rating) at study entry, an average of six years before the neuroimaging scans. | [2.0, 2.0, 2.0, 1.0, 1.0] | Medicine | train | 1.6 | news | http://ct.moreover.com/?a=33633515198&p=1pl&v=1&x=7XdGBehR5vM4s0x_RvXRiA |
10.1038/s41467-018-07418-0 | Medicine_574 | "This might initially sound easy, but really is not, since often more than half of the genes we find are so far uncharacterized and unknown." | We found indications for such plasticity in several bacterial genomes, especially within the Delta-and Gammaproteobacteria that might couple the reduction of sulfur with the oxidation of carbon, lipids or hydrocarbons. | With DNA sequencing and the computer approaches that we use, we're getting closer, and things are expanding quickly." "This might initially sound easy, but really is not, since often more than half of the genes we find are so far uncharacterized and unknown." This is not the end of the study, however, as Baker and the Alvin sampling team have joined to study areas of the basin which haven't been studied before. | Respiratory processes were often partitioned among the community and only few genomes were encoding for full pathways. We found indications for such plasticity in several bacterial genomes, especially within the Delta-and Gammaproteobacteria that might couple the reduction of sulfur with the oxidation of carbon, lipids or hydrocarbons. While we cannot determine which processes are active, enhanced genotypic diversity might provide an additional adaptation strategy to variable environmental conditions. | [1.0, 1.0, 2.0, 1.0, 2.0] | Medicine | train | 1.4 | news | http://ct.moreover.com/?a=37824353635&p=1pl&v=1&x=g1jsEMKAoFn00ytHkP11Yw |
10.1073/pnas.1713880115 | Medicine_575 | These figures show that the dogs that existed during the Mayan civilization were domesticated and given corn as food. | 12's unusual δ 13 C and δ 15 N values (Fig. | These figures show that the dogs that existed during the Mayan civilization were domesticated and given corn as food. Meanwhile, deer bones exhibited butcher marks, suggesting that they may have been hunted in the wild and are likely not fed with local crops. The cats, including a large one resembling a jaguar, showed isotope characteristics of eating wild plants. | Of the other Preclassic period animals tested in this study, the remaining dogs show consistently elevated δ 13 C values. 12's unusual δ 13 C and δ 15 N values (Fig. 2) indicate it had a unique low-maize, high-protein diet and may have been a hunting dog. | [1.0, 1.0, 1.0, 1.0, 2.0] | Medicine | train | 1.2 | news | http://ct.moreover.com/?a=33645083227&p=1pl&v=1&x=1mbfWh0JQKhF4z7h-ocIbw |
10.1073/pnas.0801268105 | Medicine_578 | The key is creating a series of tests and guidelines that check capabilities, instead of using chronological age. | The constraints of our experiments do not permit us to know how much longer we could have continued training before failing to realize any further gains in Gf. | Since people age differently, a mandatory retirement age for surgeons is unfair, Katlic and Perry say. The key is creating a series of tests and guidelines that check capabilities, instead of using chronological age. "However, we've learned that a number of physicians have opted to retire when threatened to be put through our program," Katlic says. | The dose-responsive gain in Gf indicates that the training benefit is not a threshold phenomenon. The constraints of our experiments do not permit us to know how much longer we could have continued training before failing to realize any further gains in Gf. This dose responsiveness is an important issue for further study because the exact plot of gain with training could have important practical implications for those interested in training fluid intelligence. | [1.0, 1.0, 3.0, 1.0, 1.0] | Medicine | train | 1.4 | news | http://www.npr.org/sections/health-shots/2015/06/18/414912417/when-should-surgeons-stop-operating |
10.1186/s12904-016-0129-0 | Medicine_579 | Cox diz que depois que implementou a maconha em seu ritual de luto, seu sono e humor melhoraram. | As this study compared 38 intervention persons with 86 controls, we regard the results as clinically interesting. | Se possivel, fale com um profissional de saude imparcial sobre todo o processo de luto. Cox diz que depois que implementou a maconha em seu ritual de luto, seu sono e humor melhoraram. Isso nao e surpresa, com estudos mostrando que apoio social pode melhorar os resultados do processo de luto. | Our clinical opinion is that if relevant differences in treatment effects are not detected in an intervention group of 10 to 15 persons, in spite of 10 hours counselling with three experienced facilitators, treatments are difficult to motivate as "value for money". As this study compared 38 intervention persons with 86 controls, we regard the results as clinically interesting. However, attendance rate was high at meetings so the results may give a reasonable picture. | [1.0, 1.0, 1.0, 2.0] | Medicine | train | 1.25 | news | http://ct.moreover.com/?a=39052842120&p=1pl&v=1&x=AEwoUDuaCvDghVWkGINUEA |
10.1177/0956797617692041 | Medicine_58 | The results showed that bundling seemed to diminish participants' interest in buying the larger option: People were less likely to buy a large drink when it was bundled than when it was presented as one serving. | These concerns, combined with the extant research on the contextual, social, and convenience factors affecting choice, led us to predict that bundling would not backfire and could even reduce sugary-drink purchases. | The regulation was ultimately overturned but it generated heated debate about the appropriateness and effectiveness of addressing public health issues through such means. The results showed that bundling seemed to diminish participants' interest in buying the larger option: People were less likely to buy a large drink when it was bundled than when it was presented as one serving. However, it did not affect the further downstream behavior of consumption. | In addition, a strict (although unlikely) implementation limiting sugarydrink sizes to 16 oz decreased the number of hypothetical calories purchased. These concerns, combined with the extant research on the contextual, social, and convenience factors affecting choice, led us to predict that bundling would not backfire and could even reduce sugary-drink purchases. Indeed, that a single unit (i.e., a cup) is considered a more appropriate serving size than the same quantity divided into two serving containers suggests that bundling may decrease purchasing. | [3.0, 3.0, 5.0, 2.0] | Medicine | train | 3.25 | news | http://healthmedicinet.com/news/some-strategies-to-limit-sugary-drinks-may-backfire/ |
10.1098/rspb.2009.1900 | Medicine_580 | The "watching eyes effect" makes for fun and easy citizen science. | Therefore, relatively weak forces can affect behaviour in the dictator game. | But you can see for yourself. The "watching eyes effect" makes for fun and easy citizen science. The next time you want to induce some "honest" behavior, bring along an extra pair of eyes! | A possible reason for this may be that the dictator game constitutes a less robust situation. Therefore, relatively weak forces can affect behaviour in the dictator game. Perhaps the implicit reputation cue is one of these weak forces. | [1.0, 3.0, 1.0, 1.0, 1.0] | Medicine | train | 1.4 | news | http://www.realclearscience.com/blog/2015/12/the_world_would_be_a_much_better_place_if_there_were_eyes_everywhere.html |
10.1101/lm.037291.114 | Medicine_581 | So, essentially, your age is actually a measure of chronology, physiology, sociology, and psychology, she says. | It should be mentioned that amygdalar lesions/inactivation blocked stress effects on hippocampal LTP and memory despite the increase in CORT levels (see also . | Ignore this factor at all costs, she adds. So, essentially, your age is actually a measure of chronology, physiology, sociology, and psychology, she says. "I would recommend a minimum of 12 to a maximum of 16-hour fasting period between dinner and breakfast," she says. | Since immediate, post-stress muscimol infusions into the amygdala failed to prevent stress effects on LTP and memory, it appears the critical time window of amygdalar activity is during, and not after, stress . It should be mentioned that amygdalar lesions/inactivation blocked stress effects on hippocampal LTP and memory despite the increase in CORT levels (see also . These findings suggest that the amygdala is a critical component of the central stress mechanism affecting hippocampal functioning. | [2.0, 1.0, 3.0, 1.0] | Medicine | train | 1.75 | news | http://ct.moreover.com/?a=38068224339&p=1pl&v=1&x=coI6m_VNBj546f2Li7tAQg |
10.1186/s12906-017-2062-z | Medicine_582 | Inflammation kan i sin tur visa sig nastan var som helst i kroppen. | The ESs in the Curamin and CuraMed groups were 5.9-and 5.0-fold higher than in the placebo group, with an ESs of 0.38 (confidence interval, 0.022-0.733) and 0.32 (confidence interval, 0.042-0.679) vs 0.06 (confidence interval, −0.292 -0.419) ( Table 3) . | Halso-samma saker som traning, notter, starka kryddor eller sol i stora mangder kan ocksa bidra till pittaobalans och forsamrad matsmaltning. Inflammation kan i sin tur visa sig nastan var som helst i kroppen. Alla har nagon svaghet, det kan vara huden, musklerna eller lederna. | The walking speed of a 40-m distance significantly increased from week 4 to week 12 of treatment only in the Curamin and CuraMed groups ( Fig. The ESs in the Curamin and CuraMed groups were 5.9-and 5.0-fold higher than in the placebo group, with an ESs of 0.38 (confidence interval, 0.022-0.733) and 0.32 (confidence interval, 0.042-0.679) vs 0.06 (confidence interval, −0.292 -0.419) ( Table 3) . Between-group comparisons of the changes from baseline demonstrated differences in the effect of the intervention compared to placebo. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39102394392&p=1pl&v=1&x=ATQrz5KG2CwdjZHPtq9Mgw |
10.1186/s12888-016-1111-3 | Medicine_583 | One study participant placed birds in his closest social circle. | This finding indicates a therapeutic role beyond that found previously for other long-term conditions. | The animals also could distract them from their illness, even from severe psychosis. One study participant placed birds in his closest social circle. When he was hearing voices, he said that they "help me in the sense, you know, I'm not thinking about the voices, I'm just thinking of when I hear the birds singing." | One element of the intimate relationship with pets was their input as a source of practical illness work, notably in relation to distraction and disruption from negative feelings, emotions and untoward symptoms. This finding indicates a therapeutic role beyond that found previously for other long-term conditions. But if I'm here and I'm having…having problems with voices and that, erm, it does help me in the sense, you know, I'm not thinking about the voices, I'm just thinking of when I hear the birds singing (ID 2, 2 birds, first circle). | [1.0, 4.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://healthmedicinet.com/news/pets-help-people-manage-the-pain-of-serious-mental-illness/ |
10.1073/pnas.1817205116 | Medicine_584 | Due to the accelerated melting of ice, the sea levels could rise faster too, considering that ice sheets on both Greenland and Antarctica are endangered. | The 95th percentile ice sheet contribution by 2200, for the +5°C scenario, is 7.5 m as a result of instabilities coming into play in both West and East Antarctica. | A new study adds to the plethora of evidence suggesting that we need to take action before global sea levels rise drastically, which could happen by the end of the century. Due to the accelerated melting of ice, the sea levels could rise faster too, considering that ice sheets on both Greenland and Antarctica are endangered. That's double the upper limit warned about by the UN climate science panel. | Beyond 2100, uncertainty and projected SLR increase rapidly. The 95th percentile ice sheet contribution by 2200, for the +5°C scenario, is 7.5 m as a result of instabilities coming into play in both West and East Antarctica. Introducing process correlations and tail dependences increases estimates by roughly 15%. | [4.0, 5.0, 2.0, 2.0, 3.0] | Medicine | train | 3.2 | news | http://ct.moreover.com/?a=39285629267&p=1pl&v=1&x=qjuEVjhrnSTn4j0Ie-u_kA |
10.1016/j.cub.2014.11.033 | Medicine_585 | However, as the spermathecal cells stretched upon entry of the egg, SPV-1 detached from the straightened membrane. | Taken together, our findings support a model in which SPV-1 regulates cyclical contraction of the spermatheca through transient localization to the apical membrane mediated by its F-BAR domain ( Figure 5C ). | In an empty spermatheca, SPV-1 attached to the folded, convoluted cell membranes where it acted as a protein roadblock preventing actomyosin contractility. However, as the spermathecal cells stretched upon entry of the egg, SPV-1 detached from the straightened membrane. With the roadblock removed, actomyosin contractility occured and a fertilised embryo was ejected into the uterus. | Thus, detachment of SPV-1 from the membrane, facilitated by the F-BAR domain, functions as a cue to initiate spermathecal contractility and embryo exit. Taken together, our findings support a model in which SPV-1 regulates cyclical contraction of the spermatheca through transient localization to the apical membrane mediated by its F-BAR domain ( Figure 5C ). We presume SPV-1 localization to be membrane curvature dependent. | [5.0, 3.0, 2.0, 3.0, 3.0] | Medicine | train | 3.2 | news | http://www.newswise.com/articles/epithelial-tube-contraction |
10.1089/cyber.2014.0317 | Medicine_586 | It is also related to two socioeconomic factors: GDP per capita and the Internet penetration rate. | The results revealed six extreme outliers in the data set. | Cheng and Li's work focuses on the prevalence issue, bringing together data for a more conclusive global estimate. It is also related to two socioeconomic factors: GDP per capita and the Internet penetration rate. The results of the study failed to support this hypothesis. | About half (49%) of the participants were men, and the average age was 18.42 years (SD = 5.02; range 12-41). The results revealed six extreme outliers in the data set. The prevalence rates were relatively low for the nations in Oceania and those in Northern and Western Europe, but relatively high for the nations in the Middle East. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://www.techtimes.com/articles/22541/20141219/internet-addiction-affects-6-percent-of-global-population-study.htm |
10.1111/pbi.12661 | Medicine_587 | "For cleaning up contaminated soils, grasses work best, but they're definitely not as easy to transform, especially since flexible systems to express multiple genes in grasses have not been used before," said first author and acting UW instructor Long Zhang. | After 9 days of culture, lines N5 and 18 also removed significantly more RDX from the media than wild type (P = 0.03 for N5 and 0.05 for N18). | In particular, the UW engineers had to build into their gene constructs robust monocot "promoters" -- or regions of DNA that cause a particular gene to be expressed -- for the process to work in grass species. "For cleaning up contaminated soils, grasses work best, but they're definitely not as easy to transform, especially since flexible systems to express multiple genes in grasses have not been used before," said first author and acting UW instructor Long Zhang. The research team also found another unexpected side benefit: because the genetically modified grasses use RDX as a nitrogen source, they actually grow faster than wild grass species. | The RDX removal by line N19 was not only significantly greater than that of wild type, but also greater than lines N5 and N18 (P < 0.05). After 9 days of culture, lines N5 and 18 also removed significantly more RDX from the media than wild type (P = 0.03 for N5 and 0.05 for N18). RDX levels were highest in wild-type creeping bentgrass tissues (Figure 5b ), while lower levels of RDX were detected in plant lines N5 and N18; RDX was not detected in line N19. | [2.0, 4.0, 3.0, 1.0] | Medicine | train | 2.5 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/DUrKXVO_Vac/ |
10.1038/s41564-019-0367-z | Medicine_588 | Researchers can now explain how a cell that is being attacked by bacteria or viruses specifically manages to 'sound the alarm' among its neighboring cells so they can react with a quick response. | The effect of GW4869 on Ifnb mRNA induction was not due to a general suppressive effect on Ifnb transcription, since Ifnb mRNA levels in the spleen after TLR9 agonist treatment were not affected ( Supplementary Fig. | Researchers can now explain how a cell that is being attacked by bacteria or viruses specifically manages to 'sound the alarm' among its neighboring cells so they can react with a quick response. "We've succeeded in finding and describing a messenger which both quickly and effectively can inform the surrounding cells that something is very wrong and that the cells must therefore band together to fight the foreign micro-organisms" says professor Soren Riis Paludan from the Department of Biomedicine at Aarhus University, Denmark. "The study sheds new light on how the organism quickly and effectively alarms the neighborhood, and now that we know about the mechanism, it makes sense to continue working on when it might be advantageous to give it a boost to inhibit an infection, and vice versa, when it should be blocked in order to halt an autoimmune disease," says Nandakumar. | 3g ), but not Tnfa mRNA (Fig. The effect of GW4869 on Ifnb mRNA induction was not due to a general suppressive effect on Ifnb transcription, since Ifnb mRNA levels in the spleen after TLR9 agonist treatment were not affected ( Supplementary Fig. Collectively, these results demonstrate that EV-mediated DNA transfer to bystander cells occurs during infection with intracellular bacteria. | [1.0, 3.0, 2.0, 3.0, 4.0] | Medicine | train | 2.6 | news | http://ct.moreover.com/?a=38639018346&p=1pl&v=1&x=nBHoU4YuRxGM-XtW7LCoJA |
10.1038/s41467-019-09961-w | Medicine_589 | Using MRI data, the researchers were able to show how this mechanism works in the brain. | By this process, episodic simulations modify attitudes toward the very elements that the simulations had been based on, thus influencing how we evaluate our real-life environment. | And we don't even have to actually experience the episode in reality," is how co-author Daniel Schacter sums it up. Using MRI data, the researchers were able to show how this mechanism works in the brain. But this region also evaluates how important individual people and places are for us. | Such evaluative conditioning forms attitudes by changing the liking of the CS to align with the valence of the UCS . By this process, episodic simulations modify attitudes toward the very elements that the simulations had been based on, thus influencing how we evaluate our real-life environment. Our hypothesis assigns a key role to the vmPFC in mediating such presumed attitude change. | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39250492451&p=1pl&v=1&x=6VwLkjOi_emjw_8akjADsA |
10.1001/jama.2018.7028 | Medicine_59 | When PTSD patients took SSRIs for 179 days or less, however, they had more than triple the risk of autoimmune disorders. | In addition, among patients with PTSD specifically, persistent use of SSRIs throughout the first year after diagnosis was associated with attenuated risk of autoimmune disease. | PTSD patients who took SSRIs for at least 320 days that first year after diagnosis were 82 percent more likely to develop autoimmune disorders than individuals without stress disorders, the study found. When PTSD patients took SSRIs for 179 days or less, however, they had more than triple the risk of autoimmune disorders. Roughly 9 in every 1,000 people diagnosed with stress disorders in the study developed autoimmune disorders each year, researchers calculated. | These associations were independent of history of other psychiatric disorders and became stronger with the presence of co-occurring psychiatric comorbidities. In addition, among patients with PTSD specifically, persistent use of SSRIs throughout the first year after diagnosis was associated with attenuated risk of autoimmune disease. To our knowledge, this is the first study to address all stressrelated disorders and their associations with 41 distinct autoimmune diseases in men and women using both populationand sibling-based comparisons. | [3.0, 5.0, 2.0, 3.0, 3.0] | Medicine | train | 3.2 | news | http://ct.moreover.com/?a=34345635410&p=1pl&v=1&x=x9tdQB0Ktba3xt_eBoS5xQ |
10.1111/acer.13408 | Medicine_590 | Before the intervention, says Petrenko, "parents felt they were often just pulling at straws"--guessing at what might work best. | Adapting existing interventions improves study efficiency and increases the potential for future dissemination. | "The intervention really helps parents understand their children's behavior and lets them understand why their kids are the way they are." Before the intervention, says Petrenko, "parents felt they were often just pulling at straws"--guessing at what might work best. "After program completion, having been given these tools, they feel more confident in their parenting approach." | Similar to several prior FASD interventions , results from this study document that existing interventions can be effective for children with FASD with appropriate adaptations. Adapting existing interventions improves study efficiency and increases the potential for future dissemination. Caregivers were also Bold data highlight statistically significant findings. | [1.0, 3.0, 1.0, 2.0, 1.0] | Medicine | train | 1.6 | news | http://www.futurity.org/intervention-fetal-alcohol-spectrum-disorders-parents-1412692/ |