opentargets/clinical_trial_reason_to_stop · Datasets at Hugging Face

text stringlengths 4 164	label_descriptions sequence	Another_Study bool 2 classes	Business_Administrative bool 2 classes	Covid19 bool 2 classes	Endpoint_Met bool 2 classes	Ethical_Reason bool 2 classes	Insufficient_Data bool 2 classes	Insufficient_Enrollment bool 2 classes	Interim_Analysis bool 2 classes	Invalid_Reason bool 2 classes	Logistics_Resources bool 2 classes	Negative bool 2 classes	No_Context bool 2 classes	Regulatory bool 2 classes	Safety_Sideeffects bool 2 classes	Study_Design bool 2 classes	Study_Staff_Moved bool 2 classes	Success bool 2 classes
difficulties for including diabetic patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
difficulty in achieving target enrollment numbers	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
difficulty in patients's inclusion	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
difficulty in recruiting patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
difficulty in recruiting subjects	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
difficulty in recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
difficulty obtaining required data	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
difficulty of enrolling patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
difficulty of recrutement	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
difficulty to include patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
difficulty with accrual	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
drug not available	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
drug withdrawn from market	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false
drug-related harm	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
due to COVID-19	[ "Covid19" ]	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false
due to COVID-19 (at least until 25 APRIL 2020)	[ "Covid19" ]	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false
due to COVID-19 restrictions	[ "Covid19" ]	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false
due to celecoxib safety issues	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
due to lack of finance	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
due to low enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
due to low study enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
due to multiple subjects reporting pain and burning at the phlebotomy sites after 38hr	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
due to poor enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
due to recruitment problems / based on recommendation of Independent Review Board	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
due to slow recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
due to slow recruitment of patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
due to strong side effect	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
due to very low recruitment. For this reason, there will be no further analysis and reporting of this study."	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
during Period 1 due to numerous orthostatic AEs that occurred. Subsequently, RLD was reduced to 5 mg due to safety concerns."	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
early termination due to loss of interest and low enrollment of patient	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
early termination due to slow recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
echo contrast agents no longer allowed in CAD patients.	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false
end of the follow-up period	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
enough patients have been enrolled for the statistic analysis	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
enrolling participants stopped	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
enrollment completed	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
enrollment criteria not met by PI patient population	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
enrollment difficult due to inclusion/exclusion criteria/protocol requirements	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
enrollment insufficient: lack of motivated patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
enrollment stopped for safety issues	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
enrollment was completed	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
exhausted personel after a long recruiting period	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
extremely slow enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
failed recruitment efforts	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
failure of recruiting a sufficient number of patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
failure to accrue	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
feasibility and low enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
feasibility issues	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
financial reasons	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
financial support withdrawn	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
following DSMB recommandation.	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
for administrative reasons	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
for lack of recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
four adverse events encountered	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
funding	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
funding exhausted	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
funding was withdrawn	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
funding was withdrawn from Drug company	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
funding withdrawn	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
futility	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
ganaxolone did not significantly reduce spasms after an 8-day placebo control period	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
grant funding ended and lack of sufficient participants to complete trial	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
grant was not approved.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
higher incidence of pain related sexual dysfunction in the TO arm	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
images obtained were non-diagnostic	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
immunohistochemistry markers are not recieved yet	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
inability to recruit due to administrative difficulties at the site	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
inactive	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
inadequate enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
inadequate number of enrolled study subjects	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
inadequate recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
inclusion was finished	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
inconclusive results, market feasiblity"	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
insufficent enrolement	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
insufficient enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
insufficient enrollment rate	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
insufficient enrolment	[ "Another_Study" ]	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
insufficient funding	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
insufficient number of eligible subjects	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
insufficient numbers of eligible patients as laparscopic surgery increased and open surgery decreased.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
insufficient recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
insufficient recruitment/enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
interim analysis	[ "Interim_Analysis" ]	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false
interim analysis found no difference in LB rate and lower than expected event rate	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
interim analysis indicates statistical futility for primary outcomes	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
interim analysis showed significant differences between two treatment groups	[ "Endpoint_Met" ]	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false
interim analysis suggested no differences with whole sample	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
interim review of the data indicated that the hypothesis put forth on the efficacy of a 3 day regimen was not met.	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
intermediate analysis	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
investigation of adverse events	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
investigation of adverse events in a related clinical study	[ "Another_Study" ]	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
investigator closed study	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
is finish	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
it was not possible to recruit any patient in the study	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
it was not possible to recruit new patients anymore	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
key investigator relocated.	[ "Study_Staff_Moved" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false
key personnel left institution	[ "Study_Staff_Moved" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false
key study staff left foundation	[ "Study_Staff_Moved" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false
lack of accrual	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
lack of appropriate funding	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false

difficulties for including diabetic patients

[ "Insufficient_Enrollment" ]

false

true

false

difficulty in achieving target enrollment numbers

[ "Insufficient_Enrollment" ]

false

true

false

difficulty in patients's inclusion

[ "Insufficient_Enrollment" ]

false

true

false

difficulty in recruiting patients

[ "Insufficient_Enrollment" ]

false

true

false

difficulty in recruiting subjects

[ "Insufficient_Enrollment" ]

false

true

false

difficulty in recruitment

[ "Insufficient_Enrollment" ]

false

true

false

difficulty obtaining required data

[ "Logistics_Resources" ]

false

true

false

difficulty of enrolling patients

[ "Insufficient_Enrollment" ]

false

true

false

difficulty of recrutement

[ "Insufficient_Enrollment" ]

false

true

false

difficulty to include patients

[ "Insufficient_Enrollment" ]

false

true

false

difficulty with accrual

[ "Insufficient_Enrollment" ]

false

true

false

drug not available

[ "Logistics_Resources" ]

false

true

false

drug withdrawn from market

[ "Study_Design" ]

false

true

false

drug-related harm

[ "Safety_Sideeffects" ]

false

true

false

due to COVID-19

[ "Covid19" ]

false

true

false

due to COVID-19 (at least until 25 APRIL 2020)

[ "Covid19" ]

false

true

false

due to COVID-19 restrictions

[ "Covid19" ]

false

true

false

due to celecoxib safety issues

[ "Safety_Sideeffects" ]

false

true

false

due to lack of finance

[ "Business_Administrative" ]

false

true

false

due to low enrollment

[ "Insufficient_Enrollment" ]

false

true

false

due to low study enrollment

[ "Insufficient_Enrollment" ]

false

true

false

due to multiple subjects reporting pain and burning at the phlebotomy sites after 38hr

[ "Safety_Sideeffects" ]

false

true

false

due to poor enrollment

[ "Insufficient_Enrollment" ]

false

true

false

due to recruitment problems / based on recommendation of Independent Review Board

[ "Insufficient_Enrollment" ]

false

true

false

due to slow recruitment

[ "Insufficient_Enrollment" ]

false

true

false

due to slow recruitment of patients

[ "Insufficient_Enrollment" ]

false

true

false

due to strong side effect

[ "Safety_Sideeffects" ]

false

true

false

due to very low recruitment. For this reason, there will be no further analysis and reporting of this study."

[ "Insufficient_Enrollment" ]

false

true

false

during Period 1 due to numerous orthostatic AEs that occurred. Subsequently, RLD was reduced to 5 mg due to safety concerns."

[ "Safety_Sideeffects" ]

false

true

false

early termination due to loss of interest and low enrollment of patient

[ "Insufficient_Enrollment" ]

false

true

false

early termination due to slow recruitment

[ "Insufficient_Enrollment" ]

false

true

false

echo contrast agents no longer allowed in CAD patients.

[ "Study_Design" ]

false

true

false

end of the follow-up period

[ "Invalid_Reason" ]

false

true

false

enough patients have been enrolled for the statistic analysis

[ "Invalid_Reason" ]

false

true

false

enrolling participants stopped

[ "Invalid_Reason" ]

false

true

false

enrollment completed

[ "Invalid_Reason" ]

false

true

false

enrollment criteria not met by PI patient population

[ "Insufficient_Enrollment" ]

false

true

false

enrollment difficult due to inclusion/exclusion criteria/protocol requirements

[ "Insufficient_Enrollment" ]

false

true

false

enrollment insufficient: lack of motivated patients

[ "Insufficient_Enrollment" ]

false

true

false

enrollment stopped for safety issues

[ "Safety_Sideeffects" ]

false

true

false

enrollment was completed

[ "Invalid_Reason" ]

false

true

false

exhausted personel after a long recruiting period

[ "Logistics_Resources" ]

false

true

false

extremely slow enrollment

[ "Insufficient_Enrollment" ]

false

true

false

failed recruitment efforts

[ "Insufficient_Enrollment" ]

false

true

false

failure of recruiting a sufficient number of patients

[ "Insufficient_Enrollment" ]

false

true

false

failure to accrue

[ "Insufficient_Enrollment" ]

false

true

false

feasibility and low enrollment

[ "Insufficient_Enrollment" ]

false

true

false

feasibility issues

[ "Logistics_Resources" ]

false

true

false

financial reasons

[ "Business_Administrative" ]

false

true

false

financial support withdrawn

[ "Business_Administrative" ]

false

true

false

following DSMB recommandation.

[ "Negative" ]

false

true

false

for administrative reasons

[ "Business_Administrative" ]

false

true

false

for lack of recruitment

[ "Insufficient_Enrollment" ]

false

true

false

four adverse events encountered

[ "Safety_Sideeffects" ]

false

true

false

funding

[ "Business_Administrative" ]

false

true

false

funding exhausted

[ "Business_Administrative" ]

false

true

false

funding was withdrawn

[ "Business_Administrative" ]

false

true

false

funding was withdrawn from Drug company

[ "Business_Administrative" ]

false

true

false

funding withdrawn

[ "Business_Administrative" ]

false

true

false

futility

[ "Negative" ]

false

true

false

ganaxolone did not significantly reduce spasms after an 8-day placebo control period

[ "Negative" ]

false

true

false

grant funding ended and lack of sufficient participants to complete trial

[ "Business_Administrative" ]

false

true

false

grant was not approved.

[ "Business_Administrative" ]

false

true

false

higher incidence of pain related sexual dysfunction in the TO arm

[ "Safety_Sideeffects" ]

false

true

false

images obtained were non-diagnostic

[ "Logistics_Resources" ]

false

true

false

immunohistochemistry markers are not recieved yet

[ "Logistics_Resources" ]

false

true

false

inability to recruit due to administrative difficulties at the site

[ "Business_Administrative" ]

false

true

false

inactive

[ "Invalid_Reason" ]

false

true

false

inadequate enrollment

[ "Insufficient_Enrollment" ]

false

true

false

inadequate number of enrolled study subjects

[ "Insufficient_Enrollment" ]

false

true

false

inadequate recruitment

[ "Insufficient_Enrollment" ]

false

true

false

inclusion was finished

[ "Invalid_Reason" ]

false

true

false

inconclusive results, market feasiblity"

[ "Negative" ]

false

true

false

insufficent enrolement

[ "Insufficient_Enrollment" ]

false

true

false

insufficient enrollment

[ "Insufficient_Enrollment" ]

false

true

false

insufficient enrollment rate

[ "Insufficient_Enrollment" ]

false

true

false

insufficient enrolment

[ "Another_Study" ]

true

false

insufficient funding

[ "Business_Administrative" ]

false

true

false

insufficient number of eligible subjects

[ "Insufficient_Enrollment" ]

false

true

false

insufficient numbers of eligible patients as laparscopic surgery increased and open surgery decreased.

[ "Insufficient_Enrollment" ]

false

true

false

insufficient recruitment

[ "Insufficient_Enrollment" ]

false

true

false

insufficient recruitment/enrollment

[ "Insufficient_Enrollment" ]

false

true

false

interim analysis

[ "Interim_Analysis" ]

false

true

false

interim analysis found no difference in LB rate and lower than expected event rate

[ "Negative" ]

false

true

false

interim analysis indicates statistical futility for primary outcomes

[ "Negative" ]

false

true

false

interim analysis showed significant differences between two treatment groups

[ "Endpoint_Met" ]

false

true

false

interim analysis suggested no differences with whole sample

[ "Negative" ]

false

true

false

interim review of the data indicated that the hypothesis put forth on the efficacy of a 3 day regimen was not met.

[ "Negative" ]

false

true

false

intermediate analysis

[ "Negative" ]

false

true

false

investigation of adverse events

[ "Safety_Sideeffects" ]

false

true

false

investigation of adverse events in a related clinical study

[ "Another_Study" ]

true

false

investigator closed study

[ "Invalid_Reason" ]

false

true

false

is finish

[ "Invalid_Reason" ]

false

true

false

it was not possible to recruit any patient in the study

[ "Insufficient_Enrollment" ]

false

true

false

it was not possible to recruit new patients anymore

[ "Insufficient_Enrollment" ]

false

true

false

key investigator relocated.

[ "Study_Staff_Moved" ]

false

true

false

key personnel left institution

[ "Study_Staff_Moved" ]

false

true

false

key study staff left foundation

[ "Study_Staff_Moved" ]

false

true

false

lack of accrual

[ "Insufficient_Enrollment" ]

false

true

false

lack of appropriate funding

[ "Business_Administrative" ]

false

true

false