opentargets/clinical_trial_reason_to_stop · Datasets at Hugging Face

text stringlengths 4 164	label_descriptions sequence	Another_Study bool 2 classes	Business_Administrative bool 2 classes	Covid19 bool 2 classes	Endpoint_Met bool 2 classes	Ethical_Reason bool 2 classes	Insufficient_Data bool 2 classes	Insufficient_Enrollment bool 2 classes	Interim_Analysis bool 2 classes	Invalid_Reason bool 2 classes	Logistics_Resources bool 2 classes	Negative bool 2 classes	No_Context bool 2 classes	Regulatory bool 2 classes	Safety_Sideeffects bool 2 classes	Study_Design bool 2 classes	Study_Staff_Moved bool 2 classes	Success bool 2 classes
Unable to recruit participants.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unable to recruit patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unable to recruit subjects	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unable to recruit subjects in the Turkey site.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unable to recruit subjects into the trial.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unable to recruit sufficient numbers of patients.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unable to recruit target enrollment numbers	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unable to renegotiate an expired contract w/sponsor providing study med	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Unable to secure supply of the study medication	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Unable to successfully recruit subjects to this study.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unacceptable Neurotoxicity (2 cases)	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Unacceptable incidence of wound dehiscence in the PDS group	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Unavailability of clarithromycin 250 mg in the market	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Unavailability of investigational product	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Unavailability of study article	[ "No_Context" ]	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false
Unavailable study resources	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
Under additional IRB Review	[ "Regulatory" ]	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false
Undergoing interim analysis	[ "Interim_Analysis" ]	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false
Unexpected adverse event	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Unexpected difficult recruitment. Study drug expired	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unexpected safety events.	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Unexpected side-effects: reversible and mild to moderate neurological impairment	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Unexpected withdrawal of funding	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Unexpectedely high rates of treatment-failure	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Unfavourable Pharmakokinetics	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Unforeseen difficulty identifying and enrolling eligible subjects	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unfortunately we had unforeseen difficulty recruiting to this study. Therefore we have decided to halt the study and not publish the results.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unfortunately, other Phase III clinical Study (GEM+S-1 vs GEM vs S-1) have been started in Japan."	[ "Another_Study" ]	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
UniQure, has decided not to renew the Marketing Authorization of Glybera in the EU. ThisÊ decision is not related to any safety, efficacy or quality issue	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Unknown	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
Unplanned interim analysis by DSMB indicated possible reduced response rate with the addition of Ca/Mg in pooled population. Further analysis pending.	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Unrelated serious adverse events involving one of the proposed medications	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Unsatisfactory enrollment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unsatisfactory filter deployment in several cases	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Unsuccessful recruitment	[ "Insufficient_Enrollment", "Study_Design" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	true	false	false
Unsufficient recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unsufficient referrals for recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Unusual high frequency of elevated liver function tests.	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
Urgent shift among clinical sites toward efforts to combat COVID-19 pandemic;impacted	[ "Covid19" ]	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Varience of supply chain from that required by protocol	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Ventricular rate during AF in CRT-patients much lower than expected	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Very difficult to recruit patients/slow recruitment(2 patients in nearly 2 years).	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Very low rate of recruitment anticipated futility of pursuing the study	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Very low recruitment	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Very low recruitment rate	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Very poor enrollment	[ "Insufficient_Enrollment", "Insufficient_Data" ]	false	false	false	false	false	true	true	false	false	false	false	false	false	false	false	false	false
Very poor recruitment in the Part 4 of the study	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Very poor recruitment of patients to the study	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Very slow enrollment.Study entry criteria not in line w/local standards of care	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Voluntarily closed and terminated by the PI due to lack of feasibility	[ "Logistics_Resources", "Study_Design" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	true	false	false
Voluntarily terminated based on preliminary non-clinical findings.	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Voluntary halt of further dosing due to an FDA Clinical Hold issued in relation to Dynavax study DV2-HBV-10	[ "Another_Study" ]	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Voluntary suspension due to substantial study updates and COVID-19	[ "Covid19" ]	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Waiting for FDA approval of IND	[ "Regulatory" ]	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false
Was not able to recruit enough patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Was unable to accrue any patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
We are awaiting publication of the Erythropoietin in Acute Ischemic Stroke Study(NCT00604630).	[ "Another_Study" ]	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
We believe regional anesth better for TKR,90% patients got epidural. Last year we started spinal morphine one shot, and found it very promissing."	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
We can't obtained the test drug (Vadenafil) from Bayer. They decided not to carry out this trail in Taiwan. Therefore this trail has never been started.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
We closed the study to further enrollment based on the lack of perceived need for domperidone in this population.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
We could not get funding for study.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
We could not receive the support from the national medical insurance owing to the changedÊ policy of the government for clincal trials.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
We decided that the study would not substantially add to existing contributions in the literature	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
We decided to enroll patients via e-mail rather than via telephone and are waiting for the hospital registration system to be updated with patients' e-mail.	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
We determined that the results would not be worth reporting.	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
We did not achieve a tolerogenic profile. Subjects withdrew from protocol and enrolled inÊ other islet transplant trials.	[ "Study_Design", "Insufficient_Enrollment", "Another_Study" ]	true	false	false	false	false	false	true	false	false	false	false	false	false	false	true	false	false
We did not see any effect of Palifermin on benign or malignant tumor growth	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
We didn't use this tech in patient.	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
We didnt recieved the medicine	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
We encounter technical problems to continue with the study. (Notably difficulty in teaching the patients to use the dressing set involved in the study.)	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
We failed to recruit patients	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
We found out that there is another study on the same issue	[ "Another_Study" ]	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
We had got enough data, therefore we stopped the study and published the data."	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
We had to suspend our clinical trials due to the pandemic of COVID-19.	[ "Covid19" ]	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false
We have decided to cancel this study.	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
We have recruited 16 subjects for the pilot study. The recruitment will resume once the amendments are approved for increasing sample size to 30 subjects.	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false
We need to make significant adjustments to proposed drug and its delivery method	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false
We strongly feel that the ability to recruit the required number of patients is very low andÊ thus decided to stop the study.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
We were unable to enroll a sufficient number of patients due to manpower.	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
We were unable to procure the supplement for this study.	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
We were unable to receive IVIG free from phamaceutical company.	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
We were unable to recruit sufficient patients within the confines of our budget	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
We wish to wait until there is more data available using this substance.	[ "Insufficient_Data" ]	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false
When 9 subjects of targeted 12 subjects had been studied, no changes in plasma potassium were detected and it was deemed futile to continue with enrolment."	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
When used appear DNE3 toxic properties. The DSMB determined that due to higher than expected Ê risk and safety concerns the study should be closed.	[ "Safety_Sideeffects" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false
While the GBT440 IPF results noted an improvement in oxygen saturation, they did not translateÊ into a clinically meaningful benefit.	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Will study new T-cell construct for the same indication	[ "Another_Study" ]	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Withdrawal of drug supply.	[ "Logistics_Resources" ]	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Withdrawal of marketing autorization of efalizumab by the EMEA.	[ "Regulatory" ]	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false
Withdrawal of pharmaceutical company support for the investigational drug	[ "Business_Administrative", "Logistics_Resources" ]	false	true	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false
Withdrawal of pharmaceutical support from Novartis	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Withdrawn (No Participants Enrolled)	[ "Study_Design", "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	true	false	false
Withdrawn - due to lack of accrual	[ "Insufficient_Enrollment" ]	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false
Withdrawn as NCI rescinded approval for parent study NSABP-B-45	[ "Another_Study" ]	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Withdrawn as company has shut down and filed for bankruptcy	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Withdrawn as early analysis indicated stereotactic radiosurgery not as beneficial post-op as pre-op	[ "Negative" ]	false	false	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false
Withdrawn as study has been abandoned	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
Withdrawn as study never opened	[ "Invalid_Reason" ]	false	false	false	false	false	false	false	false	true	false	false	false	false	false	false	false	false
Withdrawn as the clinical development of ATN-224 was terminated by the drug company who was providing ATN-224 for the study	[ "Business_Administrative" ]	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Withdrawn as the sponsor has stopped the drug for NSCLC population	[ "Study_Design" ]	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	false	false

Unable to recruit participants.

[ "Insufficient_Enrollment" ]

false

true

false

Unable to recruit patients

[ "Insufficient_Enrollment" ]

false

true

false

Unable to recruit subjects

[ "Insufficient_Enrollment" ]

false

true

false

Unable to recruit subjects in the Turkey site.

[ "Insufficient_Enrollment" ]

false

true

false

Unable to recruit subjects into the trial.

[ "Insufficient_Enrollment" ]

false

true

false

Unable to recruit sufficient numbers of patients.

[ "Insufficient_Enrollment" ]

false

true

false

Unable to recruit target enrollment numbers

[ "Insufficient_Enrollment" ]

false

true

false

Unable to renegotiate an expired contract w/sponsor providing study med

[ "Business_Administrative" ]

false

true

false

Unable to secure supply of the study medication

[ "Logistics_Resources" ]

false

true

false

Unable to successfully recruit subjects to this study.

[ "Insufficient_Enrollment" ]

false

true

false

Unacceptable Neurotoxicity (2 cases)

[ "Safety_Sideeffects" ]

false

true

false

Unacceptable incidence of wound dehiscence in the PDS group

[ "Safety_Sideeffects" ]

false

true

false

Unavailability of clarithromycin 250 mg in the market

[ "Logistics_Resources" ]

false

true

false

Unavailability of investigational product

[ "Logistics_Resources" ]

false

true

false

Unavailability of study article

[ "No_Context" ]

false

true

false

Unavailable study resources

[ "Invalid_Reason" ]

false

true

false

Under additional IRB Review

[ "Regulatory" ]

false

true

false

Undergoing interim analysis

[ "Interim_Analysis" ]

false

true

false

Unexpected adverse event

[ "Safety_Sideeffects" ]

false

true

false

Unexpected difficult recruitment. Study drug expired

[ "Insufficient_Enrollment" ]

false

true

false

Unexpected safety events.

[ "Safety_Sideeffects" ]

false

true

false

Unexpected side-effects: reversible and mild to moderate neurological impairment

[ "Safety_Sideeffects" ]

false

true

false

Unexpected withdrawal of funding

[ "Business_Administrative" ]

false

true

false

Unexpectedely high rates of treatment-failure

[ "Negative" ]

false

true

false

Unfavourable Pharmakokinetics

[ "Negative" ]

false

true

false

Unforeseen difficulty identifying and enrolling eligible subjects

[ "Insufficient_Enrollment" ]

false

true

false

Unfortunately we had unforeseen difficulty recruiting to this study. Therefore we have decided to halt the study and not publish the results.

[ "Insufficient_Enrollment" ]

false

true

false

Unfortunately, other Phase III clinical Study (GEM+S-1 vs GEM vs S-1) have been started in Japan."

[ "Another_Study" ]

true

false

UniQure, has decided not to renew the Marketing Authorization of Glybera in the EU. ThisÊ decision is not related to any safety, efficacy or quality issue

[ "Business_Administrative" ]

false

true

false

Unknown

[ "Invalid_Reason" ]

false

true

false

Unplanned interim analysis by DSMB indicated possible reduced response rate with the addition of Ca/Mg in pooled population. Further analysis pending.

[ "Negative" ]

false

true

false

Unrelated serious adverse events involving one of the proposed medications

[ "Safety_Sideeffects" ]

false

true

false

Unsatisfactory enrollment

[ "Insufficient_Enrollment" ]

false

true

false

Unsatisfactory filter deployment in several cases

[ "Safety_Sideeffects" ]

false

true

false

Unsuccessful recruitment

[ "Insufficient_Enrollment", "Study_Design" ]

false

true

false

true

false

Unsufficient recruitment

[ "Insufficient_Enrollment" ]

false

true

false

Unsufficient referrals for recruitment

[ "Insufficient_Enrollment" ]

false

true

false

Unusual high frequency of elevated liver function tests.

[ "Safety_Sideeffects" ]

false

true

false

Urgent shift among clinical sites toward efforts to combat COVID-19 pandemic;impacted

[ "Covid19" ]

false

true

false

Varience of supply chain from that required by protocol

[ "Logistics_Resources" ]

false

true

false

Ventricular rate during AF in CRT-patients much lower than expected

[ "Negative" ]

false

true

false

Very difficult to recruit patients/slow recruitment(2 patients in nearly 2 years).

[ "Insufficient_Enrollment" ]

false

true

false

Very low rate of recruitment anticipated futility of pursuing the study

[ "Negative" ]

false

true

false

Very low recruitment

[ "Insufficient_Enrollment" ]

false

true

false

Very low recruitment rate

[ "Insufficient_Enrollment" ]

false

true

false

Very poor enrollment

[ "Insufficient_Enrollment", "Insufficient_Data" ]

false

true

false

Very poor recruitment in the Part 4 of the study

[ "Insufficient_Enrollment" ]

false

true

false

Very poor recruitment of patients to the study

[ "Insufficient_Enrollment" ]

false

true

false

Very slow enrollment.Study entry criteria not in line w/local standards of care

[ "Insufficient_Enrollment" ]

false

true

false

Voluntarily closed and terminated by the PI due to lack of feasibility

[ "Logistics_Resources", "Study_Design" ]

false

true

false

true

false

Voluntarily terminated based on preliminary non-clinical findings.

[ "Negative" ]

false

true

false

Voluntary halt of further dosing due to an FDA Clinical Hold issued in relation to Dynavax study DV2-HBV-10

[ "Another_Study" ]

true

false

Voluntary suspension due to substantial study updates and COVID-19

[ "Covid19" ]

false

true

false

Waiting for FDA approval of IND

[ "Regulatory" ]

false

true

false

Was not able to recruit enough patients

[ "Insufficient_Enrollment" ]

false

true

false

Was unable to accrue any patients

[ "Insufficient_Enrollment" ]

false

true

false

We are awaiting publication of the Erythropoietin in Acute Ischemic Stroke Study(NCT00604630).

[ "Another_Study" ]

true

false

We believe regional anesth better for TKR,90% patients got epidural. Last year we started spinal morphine one shot, and found it very promissing."

[ "Negative" ]

false

true

false

We can't obtained the test drug (Vadenafil) from Bayer. They decided not to carry out this trail in Taiwan. Therefore this trail has never been started.

[ "Business_Administrative" ]

false

true

false

We closed the study to further enrollment based on the lack of perceived need for domperidone in this population.

[ "Business_Administrative" ]

false

true

false

We could not get funding for study.

[ "Business_Administrative" ]

false

true

false

We could not receive the support from the national medical insurance owing to the changedÊ policy of the government for clincal trials.

[ "Business_Administrative" ]

false

true

false

We decided that the study would not substantially add to existing contributions in the literature

[ "Business_Administrative" ]

false

true

false

We decided to enroll patients via e-mail rather than via telephone and are waiting for the hospital registration system to be updated with patients' e-mail.

[ "Logistics_Resources" ]

false

true

false

We determined that the results would not be worth reporting.

[ "Negative" ]

false

true

false

We did not achieve a tolerogenic profile. Subjects withdrew from protocol and enrolled inÊ other islet transplant trials.

[ "Study_Design", "Insufficient_Enrollment", "Another_Study" ]

true

false

true

false

true

false

We did not see any effect of Palifermin on benign or malignant tumor growth

[ "Negative" ]

false

true

false

We didn't use this tech in patient.

[ "Invalid_Reason" ]

false

true

false

We didnt recieved the medicine

[ "Logistics_Resources" ]

false

true

false

We encounter technical problems to continue with the study. (Notably difficulty in teaching the patients to use the dressing set involved in the study.)

[ "Logistics_Resources" ]

false

true

false

We failed to recruit patients

[ "Insufficient_Enrollment" ]

false

true

false

We found out that there is another study on the same issue

[ "Another_Study" ]

true

false

We had got enough data, therefore we stopped the study and published the data."

[ "Invalid_Reason" ]

false

true

false

We had to suspend our clinical trials due to the pandemic of COVID-19.

[ "Covid19" ]

false

true

false

We have decided to cancel this study.

[ "Invalid_Reason" ]

false

true

false

We have recruited 16 subjects for the pilot study. The recruitment will resume once the amendments are approved for increasing sample size to 30 subjects.

[ "Study_Design" ]

false

true

false

We need to make significant adjustments to proposed drug and its delivery method

[ "Study_Design" ]

false

true

false

We strongly feel that the ability to recruit the required number of patients is very low andÊ thus decided to stop the study.

[ "Insufficient_Enrollment" ]

false

true

false

We were unable to enroll a sufficient number of patients due to manpower.

[ "Insufficient_Enrollment" ]

false

true

false

We were unable to procure the supplement for this study.

[ "Logistics_Resources" ]

false

true

false

We were unable to receive IVIG free from phamaceutical company.

[ "Business_Administrative" ]

false

true

false

We were unable to recruit sufficient patients within the confines of our budget

[ "Insufficient_Enrollment" ]

false

true

false

We wish to wait until there is more data available using this substance.

[ "Insufficient_Data" ]

false

true

false

When 9 subjects of targeted 12 subjects had been studied, no changes in plasma potassium were detected and it was deemed futile to continue with enrolment."

[ "Negative" ]

false

true

false

When used appear DNE3 toxic properties. The DSMB determined that due to higher than expected Ê risk and safety concerns the study should be closed.

[ "Safety_Sideeffects" ]

false

true

false

While the GBT440 IPF results noted an improvement in oxygen saturation, they did not translateÊ into a clinically meaningful benefit.

[ "Negative" ]

false

true

false

Will study new T-cell construct for the same indication

[ "Another_Study" ]

true

false

Withdrawal of drug supply.

[ "Logistics_Resources" ]

false

true

false

Withdrawal of marketing autorization of efalizumab by the EMEA.

[ "Regulatory" ]

false

true

false

Withdrawal of pharmaceutical company support for the investigational drug

[ "Business_Administrative", "Logistics_Resources" ]

false

true

false

true

false

Withdrawal of pharmaceutical support from Novartis

[ "Business_Administrative" ]

false

true

false

Withdrawn (No Participants Enrolled)

[ "Study_Design", "Insufficient_Enrollment" ]

false

true

false

true

false

Withdrawn - due to lack of accrual

[ "Insufficient_Enrollment" ]

false

true

false

Withdrawn as NCI rescinded approval for parent study NSABP-B-45

[ "Another_Study" ]

true

false

Withdrawn as company has shut down and filed for bankruptcy

[ "Business_Administrative" ]

false

true

false

Withdrawn as early analysis indicated stereotactic radiosurgery not as beneficial post-op as pre-op

[ "Negative" ]

false

true

false

Withdrawn as study has been abandoned

[ "Invalid_Reason" ]

false

true

false

Withdrawn as study never opened

[ "Invalid_Reason" ]

false

true

false

Withdrawn as the clinical development of ATN-224 was terminated by the drug company who was providing ATN-224 for the study

[ "Business_Administrative" ]

false

true

false

Withdrawn as the sponsor has stopped the drug for NSCLC population

[ "Study_Design" ]

false

true

false