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The following are multiple choice questions (with answers) about medical knowledge. **Question:** A 43-year-old woman comes to the physician for a 3-month history of redness and itching in both eyes. She has also had swelling and pain in the index and middle fingers of both hands and wrist joints over the past 5 months. She has had multiple dental treatments for oral infections over the past year. She has type 2 diabetes mellitus and eczema. Her sister has vitiligo. Current medications include metformin and a daily multivitamin. Vital signs are within normal limits. Examination shows lichenified lesions over her wrists and knees. Bilateral wrist and first metacarpophalengeal joints show swelling and tenderness; range of motion is limited by pain. Oropharyngeal examination shows dry mucous membranes and multiple dental caries. Ophthalmologic examination is slightly decreased in both eyes. There are multiple corneal punctate spots on fluorescein staining. Laboratory studies show: Hemoglobin 10.7 g/dL Leukocyte count 4,100/mm3 Platelet count 155,000/mm3 Erythrocyte sedimentation rate 48 mm/h Serum Creatinine 1.0 mg/dL Anti-nuclear antibody positive Rheumatoid factor positive Urinalysis is within normal limits. This patient's condition is most likely associated with which of the following antibodies?" (A) Anti-U1 RNP antibodies (B) Anti-topoisomerase I antibodies (C) Anti-Jo1 antibodies (D) Anti-Ro antibodies

['(D) Anti-Ro antibodies <> answer', 'The following are multiple choice questions (with answers) about medical knowledge. <> instruction', '(A) Anti-U1 RNP antibodies (B) Anti-topoisomerase I antibodies (C) Anti-Jo1 antibodies (D) Anti-Ro antibodies <> possible answers', ' A 43-year-old woman comes to the physician for a 3-month history of redness and itching in both eyes. She has also had swelling and pain in the index and middle fingers of both hands and wrist joints over the past 5 months. She has had multiple dental treatments for oral infections over the past year. She has type 2 diabetes mellitus and eczema. Her sister has vitiligo. Current medications include metformin and a daily multivitamin. Vital signs are within normal limits. Examination shows lichenified lesions over her wrists and knees. Bilateral wrist and first metacarpophalengeal joints show swelling and tenderness; range of motion is limited by pain. Oropharyngeal examination shows dry mucous membranes and multiple dental caries. Ophthalmologic examination is slightly decreased in both eyes. There are multiple corneal punctate spots on fluorescein staining. Laboratory studies show:\nHemoglobin 10.7 g/dL\nLeukocyte count 4,100/mm3\nPlatelet count 155,000/mm3\nErythrocyte sedimentation rate 48 mm/h\nSerum\nCreatinine 1.0 mg/dL\nAnti-nuclear antibody positive\nRheumatoid factor positive\nUrinalysis is within normal limits. This patient\'s condition is most likely associated with which of the following antibodies?" <> context']

The following are multiple choice questions (with answers) about medical knowledge. **Question:** A 54-year-old woman with metastatic breast cancer comes to the physician for a follow-up examination. She had a mastectomy 6 months ago and received chemotherapy with doxorubicin and paclitaxel. A CT scan of the chest shows new metastases in the lungs and liver. Adjuvant therapy is initiated with a drug that inhibits the formation of deoxythymidine monophosphate and results in the accumulation of deoxyuridine triphosphate. The patient is advised to avoid folic acid supplementation while receiving this drug in order to prevent the toxic effects of this drug. Which of the following drugs was most likely given? (A) Hydroxyurea (B) Azathioprine (C) Mycophenolate mofetil (D) Capecitabine

['(D) Capecitabine <> answer', 'The following are multiple choice questions (with answers) about medical knowledge. <> instruction', '(A) Hydroxyurea (B) Azathioprine (C) Mycophenolate mofetil (D) Capecitabine <> possible answers', ' A 54-year-old woman with metastatic breast cancer comes to the physician for a follow-up examination. She had a mastectomy 6 months ago and received chemotherapy with doxorubicin and paclitaxel. A CT scan of the chest shows new metastases in the lungs and liver. Adjuvant therapy is initiated with a drug that inhibits the formation of deoxythymidine monophosphate and results in the accumulation of deoxyuridine triphosphate. The patient is advised to avoid folic acid supplementation while receiving this drug in order to prevent the toxic effects of this drug. Which of the following drugs was most likely given? <> context']

The following are multiple choice questions (with answers) about medical knowledge. **Question:** Which of the following cells in the body depends on dynein for its unique functioning? (A) Lower esophageal mucosal cell (B) Fallopian tube mucosal cell (C) Small intestinal mucosal cell (D) Adipocyte

['(B) Fallopian tube mucosal cell <> answer', 'The following are multiple choice questions (with answers) about medical knowledge. <> instruction', '(A) Lower esophageal mucosal cell (B) Fallopian tube mucosal cell (C) Small intestinal mucosal cell (D) Adipocyte <> possible answers', ' Which of the following cells in the body depends on dynein for its unique functioning? <> context']

The following are multiple choice questions (with answers) about medical knowledge. **Question:** A 45-year-old male with a 15-year history of diabetes mellitus presents to his primary care provider for a routine checkup. His doctor is concerned about his renal function and would like to order a test to detect renal impairment. Which of the following is the most sensitive test for detecting renal impairment in diabetic patients? (A) Cystatin C levels (B) Urine microalbumin to creatinine ratio (C) Hemoglobin A1C (D) Urine protein dipstick

['(B) Urine microalbumin to creatinine ratio <> answer', 'The following are multiple choice questions (with answers) about medical knowledge. <> instruction', '(A) Cystatin C levels (B) Urine microalbumin to creatinine ratio (C) Hemoglobin A1C (D) Urine protein dipstick <> possible answers', ' A 45-year-old male with a 15-year history of diabetes mellitus presents to his primary care provider for a routine checkup. His doctor is concerned about his renal function and would like to order a test to detect renal impairment. Which of the following is the most sensitive test for detecting renal impairment in diabetic patients? <> context']