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10.1016/j.dcn.2011.09.004

Developmental cognitive neuroscience

Dev Cogn Neurosci

Enhanced efficiency of the executive attention network after training in preschool children: immediate changes and effects after two months.

Executive attention is involved in the regulation of thoughts, emotions and responses. This function experiences major development during preschool years and is associated to a neural network involving the anterior cingulate cortex and prefrontal structures. Recently, there have been some attempts to improve attention and other executive functions through training. In the current study, a group of 5 years old children (n=37) were assigned to either a training-group who performed ten sessions of computerized training of attention or a non-trained control group. Assessment of performance in a range of tasks, targeting attention, intelligence and regulation of affect was carried out in three occasions: (1) before, (2) after, and (3) two months after completion of training. Also, brain function was examined with a high-density electroencephalogram system. Results demonstrate that trained children activate the executive attention network faster and more efficiently than untrained children, an effect that was still observed two months after without further training. Also, evidence of transfer of attention training to fluid intelligence and, to a lesser degree, to regulation of affect was observed. Results show that efficiency of the brain system underlying self-regulation can be enhanced by experience during development, providing opportunities for curricular improvement.

CognitiveConstruct

ExecutiveAttention

10.1016/j.jecp.2012.01.003

Journal of experimental child psychology

J Exp Child Psychol

Auditory and visual differences in time perception? An investigation from a developmental perspective with neuropsychological tests.

Adults and children (5- and 8-year-olds) performed a temporal bisection task with either auditory or visual signals and either a short (0.5-1.0s) or long (4.0-8.0s) duration range. Their working memory and attentional capacities were assessed by a series of neuropsychological tests administered in both the auditory and visual modalities. Results showed an age-related improvement in the ability to discriminate time regardless of the sensory modality and duration. However, this improvement was seen to occur more quickly for auditory signals than for visual signals and for short durations rather than for long durations. The younger children exhibited the poorest ability to discriminate time for long durations presented in the visual modality. Statistical analyses of the neuropsychological scores revealed that an increase in working memory and attentional capacities in the visuospatial modality was the best predictor of age-related changes in temporal bisection performance for both visual and auditory stimuli. In addition, the poorer time sensitivity for visual stimuli than for auditory stimuli, especially in the younger children, was explained by the fact that the temporal processing of visual stimuli requires more executive attention than that of auditory stimuli.

CognitiveConstruct

ExecutiveAttention

10.1017/S0140525X11001713

The Behavioral and brain sciences

Behav Brain Sci

Psychological constructionism and cultural neuroscience.

Lindquist et al. argue that emotional categories do not map onto distinct regions within the brain, but rather, arise from basic psychological processes, including conceptualization, executive attention, and core affect. Here, we use examples from cultural neuroscience to argue that psychological constructionism, not locationism, captures the essential role of emotion in the social and cultural brain.

CognitiveConstruct

ExecutiveAttention

10.1111/j.1365-2869.2012.01020.x

Journal of sleep research

J Sleep Res

Influence of acute sleep loss on the neural correlates of alerting, orientating and executive attention components.

The Attention Network Test (ANT) is deemed to assess the alerting, orientating and executive components of human attention. Capitalizing on the opportunity to investigate three facets of attention in a single task, we used functional magnetic resonance imaging (fMRI) to assess the effect of sleep deprivation (SD) on brain responses associated with the three attentional components elicited by the ANT. Twelve healthy volunteers were scanned in two conditions 1 week apart, after a normal night of sleep (rested wakefulness, RW) or after one night of total sleep deprivation. Sleep deprivation was associated with a global increase in reaction times, which did not affect specifically any of the three attention effects. Brain responses associated with the alerting effect did not differ between RW and SD. Higher-order attention components (orientating and conflict effects) were associated with significantly larger thalamic responses during SD than during RW. These results suggest that SD influences different components of human attention non-selectively, through mechanisms that might either affect centrencephalic structures maintaining vigilance or ubiquitously perturb neuronal function. Compensatory responses can counter these effects transiently by recruiting thalamic responses, thereby supporting thalamocortical function.

CognitiveConstruct

ExecutiveAttention

10.1093/ntr/nts108

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Nicotine Tob Res

Nicotine enhances alerting, but not executive, attention in smokers and nonsmokers.

Difficulty concentrating is a symptom of nicotine withdrawal that can contribute to relapse in individuals trying to quit smoking. The purpose of this study was to determine the effects of nicotine on executive and alerting attention in smokers and nonsmokers. Thirty daily smokers who were not tobacco deprived and 30 nonsmokers participated in the study. Participants received a single dose of intranasal nicotine (0, 0.5, or 1.5 mg) at each of 3 experimental sessions on separate days. Participants completed subjective ratings and 3 attention tasks before and after nicotine administration. Nicotine had no effect on executive attention as assessed by a Rapid Serial Visual Presentation (RSVP) task or the Attention Network Test in smokers and nonsmokers. In contrast, nicotine enhanced alerting attention by decreasing errors on a Continuous Performance Test (CPT) in nonsmokers and improving the correct identification of target words on the RSVP task in smokers. Nonsmokers were more sensitive than smokers to the subjective, but not the cardiovascular, effects of nicotine. The acute administration of intranasal nicotine improved alerting attention in nonsmokers as measured by the CPT, and in smokers as measured by the RSVP. Understanding the elements of attention enhanced by nicotine might guide the development of novel medications for tobacco dependence.

CognitiveConstruct

ExecutiveAttention

10.1016/j.biopsycho.2012.04.007

Biological psychology

Biol Psychol

Effortful control, depression, and anxiety correlate with the influence of emotion on executive attentional control.

Recent evidence confirms that emotion can trigger executive attentional control. Participants resolve conflict faster when encountering emotionally negative or positive stimuli. This effect is accompanied by an enlarged conflict negativity in event-related brain potentials (ERPs) and activation of the ventral anterior cingulate cortex (ACC) in fMRI. Here, we tested whether temperament (the trait effortful control) and subclinical factors (anxiety, depression) can influence the emotional modulation of executive attention. These factors correlated with conflict processing in six experiments that utilized different conflict tasks (flanker, Simon) and different types of emotional stimuli (visual, auditory). Participants high in effortful control and low in anxiety and depression responded faster to conflict processing in emotional stimuli, showed an enhanced ERP conflict negativity, and additional activation in the ventral ACC. The data show that temperamental effortful control, depression, and anxiety are related to the influence of emotion on executive attention and its underlying neural correlates.

CognitiveConstruct

ExecutiveAttention

10.3758/s13415-012-0094-x

Cognitive, affective & behavioral neuroscience

Cogn Affect Behav Neurosci

Electrodermal responses to sources of dual-task interference.

There is a response selection bottleneck that is responsible for dual-task interference. How the response selection bottleneck operates was addressed in three dual-task experiments. The overlap between two tasks (as indexed by the stimulus onset asynchrony [SOA]) was systematically manipulated, and both reaction time and electrodermal activity were measured. In addition, each experiment also manipulated some aspect of the difficulty of either task. Both increasing task overlap by reducing SOA and increasing the difficulty of either task lengthened reaction times. Electrodermal response was strongly affected by task difficulty but was only weakly affected by SOA, and in a different manner from reaction time. A fourth experiment found that the subjectively perceived difficulty of a dual-task trial was affected both by task difficulty and by SOA, but in different ways than electrodermal activity. Overall, the results were not consistent with a response selection bottleneck that involves processes of voluntary, executive attention. Instead, the results converge with findings from neural network modeling to suggest that the delay of one task while another is being processed reflects the operation of a routing mechanism that can process only one stream of information for action at a time and of a passive, structural store that temporarily holds information for the delayed task. The results suggest that conventional blocked or event-related neuroimaging designs may be inadequate to identify the mechanism of operation of the response selection bottleneck.

CognitiveConstruct

ExecutiveAttention

10.1016/j.humov.2011.11.005

Human movement science

Hum Mov Sci

Multiple measures of visual attention predict novice motor skill performance when attention is focused externally.

Multiple lines of evidence indicate that the control of attention and motor skill performance are related. Athletes of various skill levels differ in terms of their control over the focus of attention and directing athletes to adopt an internal or external focus of attention modulates performance. However, it is unclear (a) whether the relationship between skill level and attentional control arises from preexisting individual differences in attention or from practice of the motor skill and (b) whether the effect of adopting an internal or external focus of attention on motor performance is influenced by individual differences in attention. To address these issues, individuals were measured on three distinct attention functions - orienting, alerting, and executive - prior to engaging in a novel golf-putting task performed with either external or internal focus instructions. The results indicated that, on average, attentional functioning and putting performance were related but that the strong relationships with orienting and executive attention were only present in the group given external focus instructions. These findings suggest that individual differences in attentional abilities are predictive of novel skill performance under an external focus of attention and they shed light on the mechanisms underlying the effects of focus instructions during motor performance.

CognitiveConstruct

ExecutiveAttention

10.1016/j.parkreldis.2012.03.018

Parkinsonism & related disorders

Parkinsonism Relat Disord

Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait.

Freezing of gait is a common cause of disability and falls in patients with Parkinson's disease. We studied brain functional connectivity, by means of resting-state functional magnetic resonance imaging, in patients with Parkinson's disease and freezing of gait. Resting-state functional magnetic resonance imaging at 3 T was collected in 29 patients with Parkinson's disease, of whom 16 presented with freezing of gait as determined by a validated freezing of gait questionnaire, and 15 matched healthy controls. Single-subject and group-level independent component analysis was used to identify the main resting-state networks differing between Parkinson's disease patients with and without freezing of gait. Statistical analysis was performed using BrainVoyager QX. Between-group differences in resting-state networks revealed that patients with freezing of gait exhibit significantly reduced functional connectivity within both "executive-attention" (in the right middle frontal gyrus and in the angular gyrus) and visual networks (in the right occipito-temporal gyrus) [p < 0.05 corrected for multiple comparisons]. Freezing of gait clinical severity was significantly correlated with decreased connectivity within the two networks. Consistent with their "executive-attention" network impairment, patients with freezing of gait scored lower on tests of frontal lobe functions (phonemic verbal fluency: p = 0.005; frontal assessment battery: p < 0.001; ten point clock test: p = 0.04). Our findings suggest that a resting-state functional connectivity disruption of "executive-attention" and visual neural networks may be associated with the development of freezing of gait in patients with Parkinson's disease.

CognitiveConstruct

ExecutiveAttention

Zhonghua yi xue za zhi

Zhonghua Yi Xue Za Zhi

[Mechanism of impaired attention network in patients with stable chronic obstructive pulmonary disease].

To explore the influences of stable chronic obstructive pulmonary disease (COPD) on attention functions. The research objects came from the Hospital Affiliated to Anhui Medical University from February to September in 2011. Attention network test (ANT) was employed to compare stable COPD patients (n = 38) with healthy controls (n = 36) in the efficiencies of anatomically defined attentional networks: alertness, orientation and executive attention. Significant group differences were found in orientation ((27 ± 8) ms vs (57 ± 4) ms, P = 0.001), but not in alertness ((19 ± 7) ms vs (32 ± 4) ms, P = 0.115) or executive attention network ((94 ± 15) ms vs (119 ± 11) ms, P = 0.196). The accuracy of attention network test was significantly slower in the COPD group than in the healthy controls (90.2% ± 1.6% vs 96.3% ± 1.7%, P = 0.011). The score of verbal fluency test was significantly lower in COPD patients than in healthy controls (18.2 ± 0.5 vs 21.4 ± 0.6, P = 0.000). The attention functions of COPD patients are impaired, especially oriental network efficiency. It is probably due to chronic hypoxia, hypoxia-related low blood flow of temporal or parietal lobe or long-term anticholinergic drug use.

CognitiveConstruct

ExecutiveAttention

10.1016/j.bandc.2012.02.014

Brain and cognition

Brain Cogn

Hemispheric asymmetry in the efficiency of attentional networks.

Despite the fact that hemispheric asymmetry of attention has been widely studied, a clear picture of this complex phenomenon is still lacking. The aim of the present study was to provide an efficient and reliable measurement of potential hemispheric asymmetries of three attentional networks, i.e. alerting, orienting and executive attention. Participants (N=125) were tested with the Lateralized Attention Network Test (LANT) that allowed us to investigate the efficiency of the networks in both visual fields (VF). We found a LVF advantage when a target occurred in an unattended location, which seems to reflect right hemisphere superiority in control of the reorienting of attention. Furthermore, a LVF advantage in conflict resolution was observed, which may indicate hemispheric asymmetry of the executive network. No VF effect for alerting was found. The results, consistent with the common notion of general right hemisphere dominance for attention, provide a more detailed account of hemispheric asymmetries of the attentional networks than previous studies using the LANT task.

CognitiveConstruct

ExecutiveAttention

10.1037/a0027875

Journal of experimental psychology. Human perception and performance

J Exp Psychol Hum Percept Perform

The relationship between alertness and executive control.

The current study focuses on the relationship between alerting and executive attention. Previous studies reported an increased flanker congruency effect following alerting cues. In the first two experiments, we found that the alertness-congruency interaction did not exist for all executive tasks (it appeared for a flanker task but not for a Stroop task). In Experiments 3 and 4, we show that alerting increases the congruency effect in a response selection task only when the relevant and irrelevant information is spatially separated. We suggest that alerting modulates the allocation of attention by prioritizing processing of spatial information presented in the visual field. This process can be adaptive under many circumstances, but it comes at a cost. Alerting could possibly compromise our performance when required to filter out irrelevant spatial information.

CognitiveConstruct

ExecutiveAttention

10.1123/mcj.16.1.64

Motor control

Motor Control

The relationship between attention and gait in aging: facts and fallacies.

The current study critically assessed the relationship between cognitive functions and gait in nondemented older adults. Quantitative measures of gait (velocity, cadence, and a coefficient of variance in stride length) were assessed in single and dual-task conditions. Three cognitive factors captured the domains of Executive Attention, Verbal IQ, and Memory. Linear regressions showed that Executive Attention was related to velocity in both walking conditions. However, Memory and Verbal IQ were also related to velocity. Memory was related to Cadence in both walking conditions. Executive Attention was related to the coefficient of variance in stride length in both walking conditions. Linear mixed effects models showed that dual-task costs were largest in velocity followed by cadence and the coefficient of variance in stride length. The relationship between cognitive functions and gait depends, in part, on the analytic approach used, gait parameters assessed, and walking condition.

CognitiveConstruct

ExecutiveAttention

10.1523/JNEUROSCI.6048-11.2012

The Journal of neuroscience : the official journal of the Society for Neuroscience

J Neurosci

Efficient "pop-out" visual search elicits sustained broadband γ activity in the dorsal attention network.

An object that differs markedly from its surrounding-for example, a red cherry among green leaves-seems to pop out effortlessly in our visual experience. The rapid detection of salient targets, independently of the number of other items in the scene, is thought to be mediated by efficient search brain mechanisms. It is not clear, however, whether efficient search is actually an "effortless" bottom-up process or whether it also involves regions of the prefrontal cortex generally associated with top-down sustained attention. We addressed this question with intracranial EEG (iEEG) recordings designed to identify brain regions underlying a classic visual search task and correlate neural activity with target detection latencies on a trial-by-trial basis with high temporal precision recordings of these regions in epileptic patients. The spatio-temporal dynamics of single-trial spectral analysis of iEEG recordings revealed sustained energy increases in a broad gamma band (50-150 Hz) throughout the duration of the search process in the entire dorsal attention network both in efficient and inefficient search conditions. By contrast to extensive theoretical and experimental indications that efficient search relies exclusively on transient bottom-up processes in visual areas, we found that efficient search is mediated by sustained gamma activity in the dorsal lateral prefrontal cortex and the anterior cingulate cortex, alongside the superior parietal cortex and the frontal eye field. Our findings support the hypothesis that active visual search systematically involves the frontal-parietal attention network and therefore, executive attention resources, regardless of target saliency.

CognitiveConstruct

ExecutiveAttention

10.1016/j.ijpsycho.2012.02.007

International journal of psychophysiology : official journal of the International Organization of Psychophysiology

Int J Psychophysiol

Are low and high number magnitudes processed differently while resolving the conflict evoked by the SNARC effect?

In the brain, numbers are thought to be represented in a spatially organised fashion on what is known as the Mental Number Line (MNL). The SNARC (Spatial-Numerical Association of Response Codes) effect refers to the faster responses to digits when the reaction side is congruent with the digit position on the MNL (e.g. a left-handed response to a small magnitude) and the slowing down of responses (inhibition) in the case of incongruity. We examined the electrophysiological correlates of conflict, which are linked to that of inhibition, to shed light on the relationship between the SNARC effect and executive attention. Event-related potentials (ERPs) were recorded from twenty-nine participants during a parity-judgment task. The participants responded more quickly on congruent than on incongruent trials. The congruency effect was reflected in early sensory (N1, N2) components above parieto-occipital and frontal regions, as well as in the later P3 component above centro-parietal areas. Moreover, both the N1 amplitude and N2 latency were greater with high than low magnitude digit targets. P3 amplitude modulation implies that the SNARC effect is the result of first evoking the parallel processing of digit magnitude categorisation (in the occipital and central areas) and numeric conflict detection (in the parieto-occipital and frontal areas) and secondly conflict monitoring and resolution localised in the centro-parietal and frontal sites. These results also suggest that the left hemisphere specialises in conflict processing of high magnitude digit targets, while the right hemisphere of low digit magnitudes.

CognitiveConstruct

ExecutiveAttention

10.1364/JOSAA.29.000A52

Journal of the Optical Society of America. A, Optics, image science, and vision

J Opt Soc Am A Opt Image Sci Vis

Individual differences in simultaneous color constancy are related to working memory.

Few studies have investigated the possible role of higher-level cognitive mechanisms in color constancy. Following up on previous work with successive color constancy [J. Exper. Psychol. Learn. Mem. Cogn. 37, 1014 (2011)], the current study examined the relation between simultaneous color constancy and working memory-the ability to maintain a desired representation while suppressing irrelevant information. Higher working memory was associated with poorer simultaneous color constancy of a chromatically complex stimulus. Ways in which the executive attention mechanism of working memory may account for this are discussed. This finding supports a role for higher-level cognitive mechanisms in color constancy and is the first to demonstrate a relation between simultaneous color constancy and a complex cognitive ability.

CognitiveConstruct

ExecutiveAttention

10.1590/s0004-282x2012005000007

Arquivos de neuro-psiquiatria

Arq Neuropsiquiatr

Executive attention and working memory in narcoleptic outpatients.

This pioneering study aimed to evaluate executive attention and working memory in Brazilian narcoleptic outpatients. Narcoleptic group: 19 treated narcoleptic outpatients (13 F; 6 M) (mean age=37.58; SD = 8.93); control group: 19 subjects (15 F; 4 M) (mean age=34.42; SD=12.31). Epworth Sleepiness Scale - Brazilian Portuguese Version (ESS-BR), Victoria Stroop Test (VST), Trail Making Test (TMT) and Letter-Number Sequencing (LNS) of WAIS-III. Significant difference at Excessive Daytime Sleepiness (EDS) (p<0.001) and at working memory (p=0.009) with worse results for narcoleptic patients. Patients were slower at VST-1 (p=0.002), VST-2 (p=0.045) and at TMT-A (p=0.016), TMT-B (p=0.006) and B-A (p=0.024). Narcoleptic patients showed higher degrees of EDS, an impaired executive attention at a temporal level and lower performance in working memory when compared to normal controls.

CognitiveConstruct

ExecutiveAttention

10.1016/j.neuropharm.2011.12.032

Neuropharmacology

Neuropharmacology

Effects of smoking history on selective attention in schizophrenia.

Smoking prevalence is highly elevated in schizophrenia compared to the general population and to other psychiatric populations. Evidence suggests that smoking may lead to improvements of schizophrenia-associated attention deficits; however, large-scale studies on this important issue are scarce. We examined whether sustained, selective, and executive attention processes are differentially modulated by long-term nicotine consumption in 104 schizophrenia patients and 104 carefully matched healthy controls. A significant interaction of 'smoking status' × 'diagnostic group' was obtained for the domain of selective attention. Smoking was significantly associated with a detrimental conflict effect in controls, while the opposite effect was revealed for schizophrenia patients. Likewise, a positive correlation between a cumulative measure of nicotine consumption and conflict effect in controls and a negative correlation in patients were found. These results provide evidence for specific directional effects of smoking on conflict processing that critically dissociate with diagnosis. The data supports the self-medication hypothesis of smoking in schizophrenia and suggests selective attention as a specific cognitive domain targeted by nicotine consumption. A potential mechanistic model explaining these findings is discussed.

CognitiveConstruct

ExecutiveAttention

10.1016/j.pnpbp.2011.12.008

Progress in neuro-psychopharmacology & biological psychiatry

Prog Neuropsychopharmacol Biol Psychiatry

Differential effects of methylphenidate and atomoxetine on attentional processes in children with ADHD: an event-related potential study using the Attention Network Test.

Methylphenidate (MPH) and atomoxetine (ATX) are effective medications in the treatment of attention deficit/hyperactivity disorder (ADHD). The aim of this study was to investigate differential effects of MPH and ATX on attentional functions at the performance and the neuronal level in children with ADHD. Using the Attention Network Test (ANT), differential effects of both medications on the noradrenergic alerting network and the dopaminergic executive attention network were considered. Nineteen children with ADHD performed the ANT three times while event-related potentials (ERPs) were recorded. The baseline testing was conducted without medication. In two medication blocks of 8 weeks each, medication was individually titrated for each child (cross-over design, balanced order). At the end of the medication blocks the testing was repeated. While both medications comparably reduced ADHD symptomatology, MPH had some advantages over ATX with regard to performance measures on the ANT and the underlying neuronal mechanisms. Compared with ATX, MPH led to a larger reduction in reaction time variability, which was accompanied by an MPH-related increase in the contingent negative variation (CNV) compared to the baseline testing. Contrary to our expectations, specific alerting network effects were not observed with ATX. Due to the chosen study design, it remains unresolved to what extent e.g. shortened reaction times and smaller conflict scores that were observed with both medications reflect practice or medication effects. The differential pattern of MPH vs. ATX effects on attentional functions in children with ADHD may be explained by the dopaminergic effects of MPH within the cortico-striato-thalamo-cortical circuit.

CognitiveConstruct

ExecutiveAttention

10.1155/2012/863242

Child development research

Child Dev Res

The Dopamine Receptor D4 Gene 7-Repeat Allele Interacts with Parenting Quality to Predict Effortful Control in Four-Year-Old Children.

The dopamine receptor D4 gene (DRD4) 7-repeat allele has been found to interact with environmental factors such as parenting in children and peer attitudes in adults to influence aspects of behavior such as risk taking. We previously found that in toddlers, lower-quality parenting in combination with the 7-repeat allele of the DRD4 gene was associated with greater parent-reported Sensation Seeking (SS), but was unrelated to Effortful Control (EC). We now report findings from a followup assessment with the same sample of children showing that parenting quality interacts with the presence of the 7-repeat allele to predict EC in 3-to 4-year-old children. The change in these patterns of results may reflect the increased role of the executive attention network in older children and adults. However, due to the small sample size ( = 52) and the novelty of the results, these findings should be treated with caution and considered preliminary until they are replicated in an independent sample.

CognitiveConstruct

ExecutiveAttention

10.2478/v10053-008-0123-z

Advances in cognitive psychology

Adv Cogn Psychol

Event-related potential practice effects on the Paced Auditory Serial Addition Test (PASAT).

Practice can change the nature and quality of a stimulus-response relationship. The current study observed the effects of repeated administration of the Paced Auditory Serial Addition Test (PASAT) in 12 healthy individuals, in an effort to establish distinct profiles associated with novel and practiced processing. Over four training sessions the mean number of correct responses on this demanding test of attention significantly improved and was approaching ceiling for most task conditions. Behavioural improvements were associated with significantly reduced amplitude of late Processing Negativity, a frontally distributed component of the event-related potential waveform associated with voluntary, limited-capacity activity within higher-order attentional systems. These results suggest that PASAT performance became more efficient as practice seemingly eased the strategic planning and coordination requirements the task places on frontally-mediated executive attention resources. The findings of the current study extend our understanding of the functional and behavioural mechanisms underlying the effects of practice.

CognitiveConstruct

ExecutiveAttention

10.1007/s00213-011-2581-0

Psychopharmacology

Psychopharmacology (Berl)

Dorsal-striatal 5-HT₂A and 5-HT₂C receptors control impulsivity and perseverative responding in the 5-choice serial reaction time task.

Prefrontal cortex (PFC) and dorsal striatum are part of the neural circuit critical for executive attention. The relationship between 5-HT and aspects of attention and executive control is complex depending on experimental conditions and the level of activation of different 5-HT receptors within the nuclei of corticostriatal circuitry. The present study investigated which 5-HT(2A) and 5-HT(2C) receptors in the dorsomedial-striatum (dm-STR) contribute to executive attention deficit induced by blockade of NMDA receptors in the PFC. Executive attention was assessed by the five-choice serial reaction time task (5-CSRTT), which provides indices of attention (accuracy) and those of executive control over performance such as premature (an index of impulsivity) and perseverative responding. The effects of targeted infusion in dm-STR of 100 and 300 ng/μl doses of the selective 5-HT(2A) antagonist M100907 and 1 and 3 μg/μl doses of 5-HT(2C) agonist Ro60-0175 was examined in animals injected with 50 ng/μl dose of a competitive NMDA receptor antagonist 3-(R)-2-carboxypiperazin-4-phosphonic acid (CPP) in the mPFC. Blockade of NMDA receptors impaired accuracy as well as executive control as shown by increased premature and perseverative responding. The CPP-induced premature and perseverative over-responding were dose-dependently prevented by both M100907 and Ro60-0175. Both drugs partially removed the CPP-induced accuracy deficit but only at the highest dose tested. It is suggested that in the dorsal striatum, 5-HT by an action on 5-HT(2A) and 5-HT(2C) receptors may integrate the glutamate corticostriatal inputs critical for different aspects of the 5-CSRT task performance.

CognitiveConstruct

ExecutiveAttention

10.1080/00207594.2010.541255

International journal of psychology : Journal international de psychologie

Int J Psychol

The effect of music-induced mood on attentional networks.

Attention network theory suggests that there are three separate neural networks that execute the discrete functions of alerting, orienting, and executive attention. Previous research on the influence of mood on attention has shown subtle and inconsistent results. The attention network theory may aid in clarifying the influence of mood on attention. The present study investigated the influence of mood on attentional networks in a normal population. Participants performed the Attention Network Test (ANT), which provides functional measures of alerting, orienting, and executive attention. Positive or negative mood was induced by listening to music with a positive or negative valence, respectively; neutral mood was induced by reading a collection of basic facts about China. The results revealed that negative mood led to a significantly higher alerting efficiency relative to other moods, while there were no significant mood effects on orienting or executive attention efficiency. According to the algorithm underlying the ANT, the higher alerting efficiency in the negative mood condition can be attributed to relatively greater benefits of cueing effects. The findings are discussed in the context of the noradrenergic system and of evolutionary significance. Specifically, the increase in the alerting function during negative mood states may be due to the modulation effect of negative mood on the noradrenergic system, and/or to the survival benefit resulting from an increase in automatic vigilance towards negative information. The current results suggest that as the influence of negative mood on attention appears to specifically consist in an enhanced alerting function, it may not be found in studies where the three attentional networks are not dissociated.

CognitiveConstruct

ExecutiveAttention

10.1037/a0025896

Journal of experimental psychology. Learning, memory, and cognition

J Exp Psychol Learn Mem Cogn

Drifting from slow to "D'oh!": working memory capacity and mind wandering predict extreme reaction times and executive control errors.

A combined experimental, individual-differences, and thought-sampling study tested the predictions of executive attention (e.g., Engle & Kane, 2004) and coordinative binding (e.g., Oberauer, Süβ, Wilhelm, & Sander, 2007) theories of working memory capacity (WMC). We assessed 288 subjects' WMC and their performance and mind-wandering rates during a sustained-attention task; subjects completed either a go/no-go version requiring executive control over habit or a vigilance version that did not. We further combined the data with those from McVay and Kane (2009) to (1) gauge the contributions of WMC and attentional lapses to the worst performance rule and the tail, or τ parameter, of reaction time (RT) distributions; (2) assess which parameters from a quantitative evidence-accumulation RT model were predicted by WMC and mind-wandering reports; and (3) consider intrasubject RT patterns--particularly, speeding--as potential objective markers of mind wandering. We found that WMC predicted action and thought control in only some conditions, that attentional lapses (indicated by task-unrelated-thought reports and drift-rate variability in evidence accumulation) contributed to τ, performance accuracy, and WMC's association with them and that mind-wandering experiences were not predicted by trial-to-trial RT changes, and so they cannot always be inferred from objective performance measures.

CognitiveConstruct

ExecutiveAttention

10.1080/87565641.2011.591857

Developmental neuropsychology

Dev Neuropsychol

Behavioral and brain measures of executive attention and school competence in late childhood.

This study examines the role of executive attention on school competence in early adolescence. Twelve-year-old children (N = 37) performed a combined Flanker-Go/No-Go task while their brain activation was registered using electroencephalogram (EEG). Additionally, measures of children regulation, schooling skills, and academic achievement were obtained. We observed that individual differences in executive attention and Effortful Control predict most dimensions of school competence. Also, individual differences in the amplitude of event-related potentials (ERPs) related to interference suppression predict school achievement and some skills important for school. The results are consistent with the role attributed to executive attention in self-regulation.

CognitiveConstruct

ExecutiveAttention

10.1111/j.1468-1331.2011.03563.x

European journal of neurology

Eur J Neurol

European neuroborreliosis: neuropsychological findings 30 months post-treatment.

The aim of this study was to compare neuropsychological (NP) functioning in patients with Lyme neuroborreliosis (LNB) 30months after treatment to matched controls. We tested 50 patients with LNB and 50 controls with the trail-making test (TMT), Stroop test, digit symbol test, and California Verbal Learning test (CVLT). A global NP sumscore was calculated to express the number of low scores on 23 NP subtasks. Mean scores were lower amongst LNB-treated patients than amongst controls on tasks assessing attention/executive functions: (Stroop test 4: 77.6 vs. 67.0, P=0.015), response/processing speed (TMT 5: 23.4 vs. 19.2, P=0.004), visual memory (digit symbol recall: 6.6 vs. 7.2, P=0.038), and verbal memory (CVLT list B: 4.68 vs. 5.50, P=0.003). The proportion of patients and controls with NP sumscores within one SD from the mean in the control group (defined as normal) and between one and two SD (defined as deficit) were similar, but more LNB-treated patients than controls had a sumscore more than two SD from the mean (defined as impairment) (8 vs. 1, P=0.014). As a group, LNB-treated patients scored lower on four NP subtasks assessing processing speed, visual and verbal memory, and executive/attention functions, as compared to matched controls. The distribution of NP dysfunctions indicates that most LNB-treated patients perform comparable to controls, whilst a small subgroup have a debilitating long-term course with cognitive problems.

CognitiveConstruct

ExecutiveAttention

10.1007/s10484-011-9172-z

Applied psychophysiology and biofeedback

Appl Psychophysiol Biofeedback

Acutely elevated cortisol in response to stressor is associated with attentional bias toward depression-related stimuli but is not associated with attentional function.

Cortisol induces attentional bias toward a negative stimulus and impaired attentional function. Depressed individuals have high levels of cortisol, and exhibit an attentional bias toward a depression-related stimulus and impaired processing speed and executive attention, which are components of attentional function. Therefore, the study tested the hypotheses that an acute increase in cortisol in response to a stressor is associated with attentional bias toward a depression-related stimulus and impaired processing speed and executive attention. Thirty-six participants were administered the dot-probe task for the measurement of attentional bias toward a depression-related stimulus and the Trail Making Test A and B for the measurement of processing speed and executive attention before and after a mental arithmetic task. It was revealed that attentional bias toward a depression-related stimulus following the stressor was observed only among the responders (i.e., participants with cortisol elevation in response to a stressor). On the other hand, no differences in the performance of processing speed and executive attention were noted between the responders and non-responders. The results indicate that acutely elevated cortisol is related to attentional bias, but is not related to processing speed and executive attention. The results have an implication for the etiology of depression.

CognitiveConstruct

ExecutiveAttention

10.1016/j.gaitpost.2011.09.001

Gait & posture

Gait Posture

Why does older adults' balance become less stable when walking and performing a secondary task? Examination of attentional switching abilities.

Previous research using dual-task paradigms indicates balance-impaired older adults (BIOAs) are less able to flexibly shift attentional focus between a cognitive and motor task than healthy older adults (HOA). Shifting attention is a component of executive function. Task switch tests assess executive attention function. This multivariate study asked if BIOAs demonstrate greater task switching deficits than HOAs. A group of 39 HOA (65-80 years) and BIOA (65-87 years) subjects performed a visuo-spatial task switch. A sub-group of subjects performed a dual-task obstacle avoidance paradigm. All participants completed the Berg Balance Scale (BBS) and Timed Up and Go (TUG). We assessed differences by group for: (1) visuo-spatial task switch reaction times (switch/no-switch), and performance on the BBS and TUG. Our balance groups differed significantly on BBS score (p<.001) and switch reaction time (p=.032), but not the TUG. This confirmed our hypothesis that neuromuscular and executive attention function differs between these two groups. For our BIOA sub-group, gait velocity correlated negatively with performance on the switch condition (p=.036). This suggests that BIOA efficiency of attentional allocation in dual task settings should be further explored.

CognitiveConstruct

ExecutiveAttention

10.1016/j.concog.2011.09.008

Consciousness and cognition

Conscious Cogn

Lack of correlation between hypnotic susceptibility and various components of attention.

The purpose of our study was to measure the relationship between performance on various attentional tasks and hypnotic susceptibility. Healthy volunteers (N=116) participated in a study, where they had to perform several tasks measuring various attention components in a waking state: sustained attention, selective or focused attention, divided attention and executive attention in task switching. Hypnotic susceptibility was measured in a separate setting by the Waterloo-Stanford Groups Scale of Hypnotic Susceptibility, Form C (WSGC). We found no significant correlation between any of the attentional measures and hypnotic susceptibility. Highly hypnotizables did not prove to be superior to or worse than the other individuals in any of the tests. These results do not support the neuropsychophysiological model of hypnosis, as they show no consistent relationship between hypnotic susceptibility and waking attentional performance.

CognitiveConstruct

ExecutiveAttention

10.1007/s10519-011-9508-8

Behavior genetics

Behav Genet

Working memory and parent-rated components of attention in middle childhood: a behavioral genetic study.

The purpose of the current study was to investigate potential genetic and environmental correlations between working memory and three behavioral aspects of the attention network (i.e., executive, alerting, and orienting) using a twin design. Data were from 90 monozygotic (39% male) and 112 same-sex dizygotic (41% male) twins. Individual differences in working memory performance (digit span) and parent-rated measures of executive, alerting, and orienting attention included modest to moderate genetic variance, modest shared environmental variance, and modest to moderate nonshared environmental variance. As hypothesized, working memory performance was correlated with executive and alerting attention, but not orienting attention. The correlation between working memory, executive attention, and alerting attention was completely accounted for by overlapping genetic covariance, suggesting a common genetic mechanism or mechanisms underlying the links between working memory and certain parent-rated indicators of attentive behavior.

CognitiveConstruct

ExecutiveAttention

10.1037/a0025530

Developmental psychology

Dev Psychol

Control networks and neuromodulators of early development.

In adults, most cognitive and emotional self-regulation is carried out by a network of brain regions, including the anterior cingulate, insula, and areas of the basal ganglia, related to executive attention. We propose that during infancy, control systems depend primarily upon a brain network involved in orienting to sensory events that includes areas of the parietal lobe and frontal eye fields. Studies of human adults and alert monkeys have shown that the brain network involved in orienting to sensory events is moderated primarily by the nicotinic cholinergic system arising in the nucleus basalis. The executive attention network is primarily moderated by dopaminergic input from the ventral tegmental area. A change from cholinergic to dopaminergic modulation would be a consequence of this switch of control networks and may be important in understanding early development. We trace the attentional, emotional, and behavioral changes in early development related to this developmental change in regulative networks and their modulators.

CognitiveConstruct

ExecutiveAttention

10.1177/1754073910387943

Emotion review : journal of the International Society for Research on Emotion

Emot Rev

Developing Mechanisms of Self-Regulation in Early Life.

Children show increasing control of emotions and behavior during their early years. Our studies suggest a shift in control from the brain's orienting network in infancy to the executive network by the age of 3-4 years. Our longitudinal study indicates that orienting influences both positive and negative affect, as measured by parent report in infancy. At 3-4 years of age, the dominant control of affect rests in a frontal brain network that involves the anterior cingulate gyrus. Connectivity of brain structures also changes from infancy to toddlerhood. Early connectivity of parietal and frontal areas is important in orienting; later connectivity involves midfrontal and anterior cingulate areas related to executive attention and self-regulation.

CognitiveConstruct

ExecutiveAttention

10.1037/a0025250

Journal of experimental psychology. General

J Exp Psychol Gen

Why does working memory capacity predict variation in reading comprehension? On the influence of mind wandering and executive attention.

Some people are better readers than others, and this variation in comprehension ability is predicted by measures of working memory capacity (WMC). The primary goal of this study was to investigate the mediating role of mind-wandering experiences in the association between WMC and normal individual differences in reading comprehension, as predicted by the executive-attention theory of WMC (e.g., Engle & Kane, 2004). We used a latent-variable, structural-equation-model approach, testing skilled adult readers on 3 WMC span tasks, 7 varied reading-comprehension tasks, and 3 attention-control tasks. Mind wandering was assessed using experimenter-scheduled thought probes during 4 different tasks (2 reading, 2 attention-control). The results support the executive-attention theory of WMC. Mind wandering across the 4 tasks loaded onto a single latent factor, reflecting a stable individual difference. Most important, mind wandering was a significant mediator in the relationship between WMC and reading comprehension, suggesting that the WMC-comprehension correlation is driven, in part, by attention control over intruding thoughts. We discuss implications for theories of WMC, attention control, and reading comprehension.

CognitiveConstruct

ExecutiveAttention

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

Nan Fang Yi Ke Da Xue Xue Bao

[Spatiotemporal analysis of event-related potentials during mind wandering].

To investigate the neural mechanism of mind wandering. Event-related potentials (ERP) was recorded from 10 healthy college students while having a sustained attention to response task (SART), which consisted of frequent stimuli and rare stimuli with varied probability ratios. The fault response to the rare stimulus suggested the occurrence of an episode of mind wandering. The ERP of the frequent stimuli before the erroneous or correct responses of the rare stimuli were analyzed with two-way ANOVA of repeated-measurement [(wandering: yes, no)×(probability ratio: 0.1/0.9, 0.2/0.8, 0.3/0.7)]. The reaction time of the error response was shorter than that of the correct one. Significant probability effects were also found: the larger the frequent probability, the shorter its reaction time and the lower its accuracy. The sensitivity d' had no significant effect. The statistical parametric mapping of ERP suggested an interaction effect in the bilateral parietal areas (500-600 ms) and frontal areas (800-900 ms); the probability effect occurred in the left prefrontal lobe and the right parietal lobe (300-350 ms) and mind wandering effect in the bilateral occipital lobes (150-350 ms), frontal poles (250-300 ms), bilateral frontal-temporal-parietal regions (400-600 ms) and left prefrontal (800-900 ms). During mind wandering, the activation of cognitive processing for environment information decreases and speedy responses are more common with faults. The functional failure of the executive attention system influenced by the probability structure of SART may cause the occurrence of mind wandering.

CognitiveConstruct

ExecutiveAttention

10.1080/17470218.2011.597865

Quarterly journal of experimental psychology (2006)

Q J Exp Psychol (Hove)

Variation in working memory capacity and cognitive control: goal maintenance and microadjustments of control.

Variation in working memory capacity (WMC) and cognitive control was examined in four experiments. In the experiments high- and low-WMC individuals performed a choice reaction time task (Experiment 1), a version of the antisaccade task (Experiment 2), a version of the Stroop task (Experiment 3), and an arrow version of the flanker task (Experiment 4). An examination of response time distributions suggested that high- and low-WMC individuals primarily differed in the slowest responses in each experiment, consistent with the notion that WMC is related to active maintenance abilities. Examination of two indicators of microadjustments of control (posterror slowing and conflict adaptation effects) suggested no differences between high- and low-WMC individuals. Collectively these results suggest that variation in WMC is related to some, but not all, cognitive control operations. The results are interpreted within the executive attention theory of WMC.

CognitiveConstruct

ExecutiveAttention

10.1111/j.1467-789X.2011.00903.x

Obesity reviews : an official journal of the International Association for the Study of Obesity

Obes Rev

Intentional weight loss in overweight and obese individuals and cognitive function: a systematic review and meta-analysis.

High adiposity in middle age is associated with higher dementia risk. The association between weight loss and cognitive function in older adults is still controversial. A meta-analysis was undertaken to estimate the effectiveness of intentional weight loss on cognitive function in overweight and obese adults. A structured strategy was used to search randomized and non-randomized studies reporting the effect of intentional and significant weight loss on cognitive function in overweight and obese subjects. Information on study design, age, nutritional status, weight-loss strategy, weight lost and cognitive testing was extracted. A random-effect meta-analysis was conducted to obtain summary effect estimates for memory and attention-executive domains. Twelve studies met inclusion criteria. Seven were randomized trials and the remaining five included a control group. A low-order significant effect was found for an improvement in cognitive performance with weight loss in memory (effect size 0.13, 95% CI 0.00-0.26, P=0.04) and attention/executive functioning (effect size 0.14, 95% CI 0.01-0.27, P<0.001). Studies were heterogeneous in study design, sample selection, weight-loss intervention and assessment of cognitive function. Weight loss appears to be associated with low-order improvements in executive/attention functioning and memory in obese but not in overweight individuals.

CognitiveConstruct

ExecutiveAttention

10.3389/fpsyg.2011.00123

Frontiers in psychology

Front Psychol

The efficiency of attentional networks in early and late bilinguals: the role of age of acquisition.

Previous studies have demonstrated a bilingual advantage in the efficiency of executive attention. A question remains, however, about the impact of the age of L2 acquisition and relative balance of the two languages on the enhancement of executive functions in bilinguals, and whether this is modulated by the similarity of the bilingual's two languages. The present study explores these issues by comparing the efficiency of attentional networks amongst three groups of young adults living in Australia: English monolinguals and early and late Chinese-English bilinguals. We also address the impact of bilingualism on hemispheric lateralization of cognitive functions, which is of interest since a recent study on early bilinguals revealed reduced hemispheric asymmetry in attentional functioning. In the present study, participants performed a modified version of the lateralized attention network test. Both early and late bilinguals were found to have more efficient executive network than monolinguals. The late bilinguals, who were also reported to be more balanced in the proficiency and usage of their two languages, showed the greatest advantage in conflict resolution, whereas early bilinguals seemed to show enhanced monitoring processes. These group differences were observed when controlling for non-verbal intelligence and socioeconomic status. Such results suggest that specific factors of language experience may differentially influence the mechanisms of cognitive control. Since the bilinguals had distinct language sets, it seems that the influence of bilingualism on executive functions is present regardless of the similarity between the two languages. As for hemispheric lateralization, although the results were not clear-cut, they suggest the reduced lateralization in early bilinguals.

CognitiveConstruct

ExecutiveAttention

10.1037/a0024369

Emotion (Washington, D.C.)

Emotion

The impact of task-irrelevant emotional stimuli on attention in three domains.

Whether task-irrelevant emotional stimuli facilitate or disrupt attention performance may depend on a range of factors, such as emotion type, task difficulty, and stimulus duration. Few studies, however, have systematically examined the influence of these factors on attention performance. Sixty-three adults, scoring within a normative range for mood and anxiety symptoms, completed either an easy or difficult version of an attention task measuring three aspects of attention performance: alerting, orienting, and executive attention. Results showed that in the easy task only, threatening versus nonthreatening task-irrelevant emotional faces facilitated orienting regardless of stimulus duration. These effects were no longer significant during the difficult condition. When the easy and difficult conditions were examined together, duration effects emerged such that stimuli of longer durations lead to greater interference, although effects were nonlinear. Findings illustrate that threat-relevant emotional stimuli facilitate attention during tasks with low cognitive load, but underscore the importance of considering a range of task parameters. Results are discussed in the context of adaptive and maladaptive emotion-attention interactions.

CognitiveConstruct

ExecutiveAttention

10.1111/j.1467-7687.2011.01038.x

Developmental science

Dev Sci

Prenatal cigarette exposure and infant learning stimulation as predictors of cognitive control in childhood.

Prenatal exposures to neurotoxins and postnatal parenting practices have been shown to independently predict variations in the cognitive development and emotional-behavioral well-being of infants and children. We examined the independent contributions of prenatal cigarette exposure and infant learning stimulation, as well as their inter-relationships in predicting variations in the proficiency of executive attention, a core element of cognitive control and self-regulation. Participants were an ethnic-racially, socio-economically diverse sample of 249 children followed from birth in the Project on Human Development in Chicago Neighborhoods. We obtained histories of prenatal exposure to alcohol, cigarettes, and other drugs, and we assessed socio-economic status and learning stimulation during a home visit when the participants were infants. In childhood we utilized the Attention Networks Test to assess the proficiency of executive attention during two home visits, one year apart. Accounting for age, SES, prenatal alcohol exposure, and baseline performance, we found that prenatal cigarette exposure impaired the speed of executive attention. Infant learning stimulation mitigated these effects, and predicted better accuracy of executive attention as well, suggestive of both protective and health promoting effects. Effect sizes for these relations, whether examined independently or by their inter-relationships, were comparable to if not greater in magnitude than the effects of age on speed and accuracy, highlighting the importance of these very early experiences in shaping the proficiency of self-regulation. Since executive attention is central to cognitive control and self-regulation, previously described relations between prenatal cigarette exposure, parenting practices, and some forms of childhood psychopathology may be contingent on how early learning stimulation contributes to the proficiency of executive attention through direct and indirect effects. Furthermore, considering the prolonged developmental trajectory of executive attention, interventions to support provision of learning stimulation may mitigate poor outcomes for some at-risk children by promoting development of more proficient executive attention.

CognitiveConstruct

ExecutiveAttention

10.1080/17470218.2011.577226

Quarterly journal of experimental psychology (2006)

Q J Exp Psychol (Hove)

Integrating working memory capacity and context-processing views of cognitive control.

Individuals low in working memory capacity (WMC) exhibit impaired performance on a variety of cognitive control tasks. The executive-attention theory of WMC (Engle & Kane, 2004) accounts for these findings as failures of goal maintenance and response conflict resolution. Similarly, the context-processing view (Braver et al., 2001) provides an explanation of cognitive control deficits observed in schizophrenia patients and older adults that is based on the ability to maintain context information. Instead of maintenance deficits, the inhibition view (Hasher, Lustig, & Zacks, 2007) states that older adults and individuals low in WMC primarily have an impairment in the ability to inhibit information. In the current experiment, we explored the relationships among these theories. Individuals differing in performance on complex span measures of WMC performed the AX-Continuous Performance Test to measure context-processing performance. High-WMC individuals were predicted to maintain the context afforded by the cue, whereas low-WMC individuals were predicted to fail to maintain the context information. Low-WMC individuals made more errors on AX and BX trials and were slower to respond correctly on AX, BX, and BY trials. The overall pattern of results is most consistent with both the executive-attention and context-processing theories of cognitive control.

CognitiveConstruct

ExecutiveAttention

10.1007/s10802-011-9522-6

Journal of abnormal child psychology

J Abnorm Child Psychol

Attention network performance and psychopathic symptoms in early adolescence: an ERP study.

Reaction time (RT) and event-related potential (ERP) measures were used to examine the relationships between psychopathic symptoms and three major attention networks (alerting, orienting, and executive attention) among a community sample of youth. Antisocial Process Screening Device (APSD; Frick and Hare 2001) total and subscale scores were negatively correlated with ERP measures of attentional alerting, indicating that youth with psychopathic symptoms had difficulty using warning cues to prepare for upcoming targets. APSD total scores were not related to performance on measures of orienting or executive attention, although weaker executive attention was found among youth with higher scores on the Impulsivity subscale. These findings support attention-based models of psychopathy and provide evidence of specific deficits in attentional alerting among youth with psychopathic traits. Deficiencies in attentional alerting may be related to noradrenergic functioning and may have cascading effects on higher order cognitive and affective processing.

CognitiveConstruct

ExecutiveAttention

10.1007/s11689-010-9070-3

Journal of neurodevelopmental disorders

J Neurodev Disord

Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome.

Impairment in the executive control of attention has been found in youth with chromosome 22q11.2 deletion syndrome (22q11.2DS). However, how this impairment is modified by other factors, particularly age, is unknown. Forty-six typically developing and 53 children with 22q11.2DS were tested with the attention networks task (ANT) in this cross-sectional study. We used logarithmic transform and linear modeling to assess age effects on the executive index of the ANT. Mixed modeling accounted for between subject variability, age, handedness, catecholamine-O-transferase (COMT; codon 158) genotype, and gender on performance for all experimental conditions (cue × flanker) and their two-level interactions. Children with 22q11.2DS showed a relative, age-dependent executive index impairment but not orienting or alerting network index impairments. In factorial analysis, age was a major predictor of overall performance. There was a significant effect of the 22q11.2DS on overall performance. Of note, children with 22q11.2DS are specifically vulnerable to incongruent flanker interference, especially at younger ages. We did not find an overall effect of COMT genotype or handedness. Children with 22q11.2DS demonstrated age-related impairment in the executive control of attention. Future investigation will likely reveal that there are different developmental trajectories of executive attentional function likely related to the development of schizophrenia in 22q11.2DS.

CognitiveConstruct

ExecutiveAttention

10.1080/02699931.2010.541668

Cognition & emotion

Cogn Emot

Deliberate real-time mood regulation in adulthood: the importance of age, fixation and attentional functioning.

While previous research has linked executive attention to emotion regulation, the current study investigated the role of attentional alerting (i.e., efficient use of external warning cues) on younger (N=39) and older (N=44) adults' use of gaze to regulate their mood in real time. Participants viewed highly arousing unpleasant images while reporting their mood and were instructed to deliberately manage how they felt and to minimise the effect of those stimuli on their mood. Fixations toward the most negative areas of the images were recorded with eye tracking. We examined whether looking less at the most negative regions, compared to each individual's own tendency, was a beneficial mood regulatory strategy and how it interacted with age and alerting ability. High alerting older adults, who rely more on external cues to guide their attention, experienced a smaller decline in mood over time by activating a less-negative-looking approach (compared to their own average tendency), effectively looking away from the most negative areas of the images. More negative gaze patterns predicted better mood for younger adults, though this effect decreased over time. Alerting did not moderate gaze-mood links in younger adults. Successful mood regulation may thus depend on particular combinations of age, fixation, and attention.

CognitiveConstruct

ExecutiveAttention

10.1016/j.neuroimage.2011.01.072

NeuroImage

Neuroimage

Developmental effects of reward on sustained attention networks.

Adolescence is typified by significant maturation in higher-level attention functions coupled with less developed control over motivation, and enhanced sensitivity to novelty and reward. This study used event-related functional magnetic resonance imaging (fMRI) in seventy male and female participants aged between 10 and 43 years to identify age-related linear changes in cognitive sustained attention systems and the impact of reward on these systems, using a sustained attention task with and without a rewarded condition. For the non-rewarded sustained attention contrast, increasing age was associated with activation increases in typical regions of sustained attention including right inferior frontal, superior temporo-parietal and cerebellar cortices. Age-related activation decreases were observed within more posterior regions including posterior cingulate, insula and posterior cerebellar cortices, presumably mediating visual-spatial saliency detection. The effect of reward on sustained attention networks was associated with increased activation with age in regions associated with both executive attention control and reward processing, including dorsolateral, inferior and ventromedial prefrontal cortices (PFC), striatum, and temporo-parietal regions, suggestive of greater integration and executive control of motivation and cognition with maturity. Activation in paralimbic posterior cingulate and inferior temporal brain regions of visual-spatial saliency processing was progressively reduced in activation with increasing development. Thus, with increasing development between adolescence and adulthood, reward appears to enhance maturing cognitive sustained attention and executive reward-processing networks, whilst reducing paralimbic regions of saliency detection. These findings may be the neural underpinnings for the progressive maturation of motivational control over risk taking behaviours between adolescence and adulthood.

CognitiveConstruct

ExecutiveAttention

10.1080/87565641.2011.540538

Developmental neuropsychology

Dev Neuropsychol

Attention problems in a representative sample of extremely preterm/extremely low birth weight children.

The aim of this study was to examine attention in a large, representative, contemporary cohort of children born extremely preterm (EP) and/or extremely low birth weight (ELBW). Participants included 189 of 201 surviving children born EP (<28 weeks' gestation) or ELBW (<1,000 g) in 1997 in the state of Victoria, Australia. A comparison group of 173 of 199 children born full term and normal birth weight (FT/NBW) were randomly selected matching for birth hospital, expected due date, gender, mother's country of birth, and health insurance status. Participants were assessed at 8 years of age on subtests from the Test of Everyday Attention for Children (TEA-Ch) and the Wechsler Intelligence Scale for Children-4th Edition (WISC-IV). Measures of selective attention, sustained attention, attention encoding, and executive attention (inhibition, shifting attention, and divided attention) were administered. To assess behavioral elements of inattention, the primary caregiver completed the Behavior Rating Inventory of Executive Function (BRIEF) and the Conners' ADHD/DSM-IV Scale (CADS-P). The EP/ELBW group performed more poorly across all cognitive and behavioral measures than the FT/NBW group, with the exception of inhibition. The EP/ELBW group also had significantly elevated rates of impairment in selective, sustained, shifting and divided attention, as well as attention deficit hyperactivity disorder (ADHD) symptoms. No significant gender or gradient effects (e.g., <26 weeks' gestation vs. ≥ 26 weeks' gestation) were identified. Neonatal medical factors were not strong predictors of attention, although necrotizing enterocolitis (NEC) and cystic periventricular leukomalacia (PVL) were independent predictors of selective attention. In conclusion, our comprehensive assessment of attention provides strong evidence that children born EP/ELBW are at increased risk for attentional impairments, and as such, this population should be monitored closely during early and middle childhood with a focus on attention functioning.

CognitiveConstruct

ExecutiveAttention

10.1016/j.bandc.2010.12.003

Brain and cognition

Brain Cogn

Age-related differences in attentional networks of alerting and executive control in young, middle-aged, and older Chinese adults.

Previous studies suggest that aging is associated with impairment of attention. However, it is not known whether this represents a global attentional deficit or relates to a specific attentional network. We used the attention network test to examine three groups of younger, middle-aged, and older participants with respect to the efficiency of three anatomically defined attentional networks: alerting network, orienting network, and executive control network. Age-related change was found to have the greatest effect on the executive network and the least effect on the alerting network as well as on overall mean response time. Impairment of the orienting network was found to be insignificant. Age-related deterioration of the prefrontal lobe, the dopaminergic system, and function of specific genes may explain the age-related changes in executive attention, which occur after the fourth decade of life.

CognitiveConstruct

ExecutiveAttention

10.1016/j.cpr.2010.11.003

Clinical psychology review

Clin Psychol Rev

Does mindfulness training improve cognitive abilities? A systematic review of neuropsychological findings.

Mindfulness meditation practices (MMPs) are a subgroup of meditation practices which are receiving growing attention. The present paper reviews current evidence about the effects of MMPs on objective measures of cognitive functions. Five databases were searched. Twenty three studies providing measures of attention, memory, executive functions and further miscellaneous measures of cognition were included. Fifteen were controlled or randomized controlled studies and 8 were case-control studies. Overall, reviewed studies suggested that early phases of mindfulness training, which are more concerned with the development of focused attention, could be associated with significant improvements in selective and executive attention whereas the following phases, which are characterized by an open monitoring of internal and external stimuli, could be mainly associated with improved unfocused sustained attention abilities. Additionally, MMPs could enhance working memory capacity and some executive functions. However, many of the included studies show methodological limitations and negative results have been reported as well, plausibly reflecting differences in study design, study duration and patients' populations. Accordingly, even though findings here reviewed provided preliminary evidence suggesting that MMPs could enhance cognitive functions, available evidence should be considered with caution and further high quality studies investigating more standardized mindfulness meditation programs are needed.

CognitiveConstruct

ExecutiveAttention

10.1093/arclin/acq095

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Arch Clin Neuropsychol

Attentional functions in major depressive disorders with and without comorbid anxiety.

The aim of this study was to explore if the divergent results regarding attentional functions in patients with mood disorders are due to selective impairments in higher level or more basic and distinctive attentional subcomponents. We compared outpatients with current major depressive disorders (MDD; n = 37) and MDD with comorbid anxiety disorder (MDDA; n = 24) with healthy controls (n = 92) on Stroop and Attentional Network Test (ANT). The current data indicate that significant impairment in attentional functions corresponds to the presence of MDD and MDDA. MDDA displayed significantly lower performance on the Stroop variables, and MDD were significantly impaired in the alerting function in ANT. These results show impairments on different levels of attention in mood disorders. MDDA show impairments on higher level executive attention functions, whereas MDD display deficits at the basic attentional level. These findings suggest that including comorbid anxiety disorder in MDD is important for future research.

CognitiveConstruct

ExecutiveAttention

10.1080/13825585.2010.517826

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn

Cognitive fatigue defined in the context of attention networks.

We examined the effect of cognitive fatigue on the Attention Networks Test (ANT). Participants were 228 non-demented older adults. Cognitive fatigue was operationally defined as decline in alerting, orienting, and executive attention performance over the course of the ANT. Anchored in a theoretical model implicating the frontal basal ganglia circuitry as the core substrate of fatigue, we hypothesized that cognitive fatigue would be observed only in executive attention. Consistent with our prediction, significant cognitive fatigue effect was observed in executive attention but not in alerting or orienting. In contrast, orienting improved over the course of the ANT and alerting showed a trend, though insignificant, that was consistent with learning. Cognitive fatigue is conceptualized as an executive failure to maintain and optimize performance over acute but sustained cognitive effort resulting in performance that is lower and more variable than the individual's optimal ability.

CognitiveConstruct

ExecutiveAttention

10.1002/hbm.21012

Human brain mapping

Hum Brain Mapp

Emotion triggers executive attention: anterior cingulate cortex and amygdala responses to emotional words in a conflict task.

Coherent behavior depends on attentional control that detects and resolves conflict between opposing actions. The current functional magnetic resonance imaging study tested the hypothesis that emotion triggers attentional control to speed up conflict processing in particularly salient situations. Therefore, we presented emotionally negative and neutral words in a version of the flanker task. In response to conflict, we found activation of the dorsal anterior cingulate cortex (ACC) and of the amygdala for emotional stimuli. When emotion and conflict coincided, a region in the ventral ACC was activated, which resulted in faster conflict processing in reaction times. Emotion also increased functional connectivity between the ventral ACC and activation of the dorsal ACC and the amygdala in conflict trials. These data suggest that the ventral ACC integrates emotion and conflict and prioritizes the processing of conflict in emotional trials. This adaptive mechanism ensures rapid detection and resolution of conflict in potentially threatening situations signaled by emotional stimuli.

CognitiveConstruct

ExecutiveAttention

Hospitals & health networks

Hosp Health Netw

Billing & coding. ICD-10: experts fear executive attention lags.

CognitiveConstruct

ExecutiveAttention

10.1017/S1355617710000767

Journal of the International Neuropsychological Society : JINS

J Int Neuropsychol Soc

Alerting, orienting, and executive attention in older adults.

The Attention Network Test (ANT) assesses alerting, orienting, and executive attention. The current study was designed to achieve three main objectives. First, we determined the reliability, effects, and interactions of attention networks in a relatively large cohort of non-demented older adults (n = 184). Second, in the context of this aged cohort, we examined the effect of chronological age on attention networks. Third, the effect of blood pressure on ANT performance was evaluated. Results revealed high-reliability for the ANT as a whole, and for specific cue and flanker types. We found significant main effects for the three attention networks as well as diminished alerting but enhanced orienting effects during conflict resolution trials. Furthermore, increased chronological age and low blood pressure were both associated with significantly worse performance on the executive attention network. These findings are consistent with executive function decline in older adults and the plausible effect of reduced blood flow to the frontal lobes on individual differences in attention demanding tasks.

CognitiveConstruct

ExecutiveAttention

10.3109/07420528.2010.489400

Chronobiology international

Chronobiol Int

Diurnal patterns of activity of the orienting and executive attention neuronal networks in subjects performing a Stroop-like task: a functional magnetic resonance imaging study.

Attentional processes are fundamental to good cognitive functioning of human operators. The purpose of this study was to analyze the activity of neuronal networks involved in the orienting attention and executive control processes from the perspective of diurnal variability. Twenty-three healthy male volunteers meeting magnetic resonance (MR) inclusion criteria performed the Stroop Color-Word task (block design) in the MR scanner five times/day (06:00, 10:00, 14:00, 18:00, 22:00 h). The first scanning session was scheduled 1-1.5 h after waking. Between MR sessions, subjects performed simulated driving tasks in stable environmental conditions, with controlled physical activity and diet. Significant activation was found in brain regions related to the orienting attentional system: the parietal lobe (BA40) and frontal eye-fields (FEFs). There were also activations in areas of the executive control system: the fronto-insular cortex (FIC), dorsal anterior cingulate cortex (dACC), presupplementary motor area (preSMA), supplementary motor area (SMA), basal ganglia, middle temporal (MT; BA21), and dorsolateral prefrontal cortex (DLPFC), as a part of the central executive network. Significant deactivations were observed in the rostral anterior cingulate cortex (rACC), posterior cingulate cortex (PCC), superior frontal gyrus (SF), parietal lobe (BA39), and parahippocampal that are thought to comprise the default mode network (DMN). Additionally, the activated regions included bilaterally lingual gyrus and fusiform gyrus. The insula was bilaterally deactivated. Visual attention controlled by the goal-oriented attention system and comprising top-down and bottom-up mechanisms, activated by Stroop-like task, turned out to be prone to diurnal changes. The study results show the occurrence of time-of-day-related variations in neural activity of brain regions linked to the orienting attentional system (left parietal lobe-BA40, left and right FEFs), simultaneously providing arguments for temporal stability of the executive system and default mode network. These results also seem to suggest that the involuntary, exogenous (bottom-up) mechanism of attention is more vulnerable to circadian and fatigue factors than the voluntary (top-down) mechanism, which appear to be maintained at the same functional level during the day. The above phenomena were observed at the neural level.

CognitiveConstruct

ExecutiveAttention

10.1016/j.bbr.2010.06.023

Behavioural brain research

Behav Brain Res

Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse.

Control of attention is a key mechanism underlying behavior regulation. In this study we detail the aspects of attention that covary with the chronic use of cannabis throughout adolescence. We compared performance and brain activation differences in tasks involving attention between young adults with a history of chronic cannabis use during adolescence and matched non-user control subjects. Two tasks were used to activate attention networks: the Attention Network Task (ANT) and the use generation task. In the ANT, chronic users (N=14) differed from controls (N=14) in showing poorer performance (longer reaction time and more errors) on tasks requiring processing of incongruent stimuli reflecting the executive attention network, but not in networks related to alerting or orienting components of attention. Functional MRI of brain activity showed stronger activation within the right prefrontal cortex in chronic users compared to the control group specifically on ANT trials requiring executive attention. The use generation task also revealed significantly stronger activation of the same right prefrontal area in users compared to controls. These results suggest that chronic cannabis users have less efficient executive attention in conflict resolution tasks, demanding more activation in the right prefrontal areas to resolve conflict.

CognitiveConstruct

ExecutiveAttention

10.1080/10503301003636696

Psychotherapy research : journal of the Society for Psychotherapy Research

Psychother Res

Conflict begets conflict: executive control, mental state vacillations, and the therapeutic alliance in treatment of borderline personality disorder.

Clinicians routinely note the challenges involved in psychotherapy with individuals with BPD, yet little research exists on the therapeutic alliance with this population. An important question is, what patient factors contribute to a disturbed alliance with individuals with BPD? Executive attention has been identified as a mechanism of BPD, and mental state vacillations (e.g., idealization/denigration, incoherence in self-concept) are a hallmark of the disorder. The goals of this study were to examine the link between executive attention and the alliance and assess mental state vacillations as a mediator. Thirty-nine participants diagnosed with BPD, participating in a randomized clinical trial, were administered the Attentional Network Task (ANT). Early psychotherapy sessions were coded using the Working Alliance Inventory (WAI). In addition, six items were generated and coded representing in-session vacillations in mental states. Performance on the ANT was related to the alliance (r =.34, p =.035), as were in-session mental state vacillations (r =.59, p <.001). A model was supported in which in-session mental state vacillations mediated the relationship between executive attention and alliance. Executive attention was related to therapeutic alliance, and this relationship was found to be mediated by in-session mental state vacillations. These findings emphasize the importance of executive attention in the disorder and uncover a link between poor executive attention and mental state vacillations. Mental state vacillations as a mediator suggests a path in which poor executive attention leads to greater vacillations, which leads to poorer working alliance.

CognitiveConstruct

ExecutiveAttention

10.1037/a0017729

Psychology and aging

Psychol Aging

Executive function in daily life: Age-related influences of executive processes on instrumental activities of daily living.

The present study of older adults used structural equation modeling (SEM) to examine the relationships between 3 executive processes underlying executive function (EF) (inhibition, task switching, updating in working memory), and 2 types of instrumental activities of daily living (IADLs) (self-report, performance based). Experimental tasks of executive attention and self-report or performance-based IADL tests were administered to create latent constructs of EF and IADLs. Confirmatory factor analysis (CFA) was used to examine the construct validity of EF and IADLs. This analysis indicated a 3-factor model of inhibition, updating, and task switching and a 2-factor model of self-report and performance-based IADLs. As predicted, when the latent variable relationships were analyzed, executive processes had a significant relationship with performance-based, but not self-report, IADLs. In addition, task switching had a strong and significant relationship with performance-based IADLs. The results of this study uniquely show a direct relationship between executive processes and performance-based IADLs, thus demonstrating the ecological utility of experimental measures of EF to predict daily function. Furthermore, these results point to areas of cognitive training that may strategically impact older adults' performance on daily life activities.

CognitiveConstruct

ExecutiveAttention

10.1177/1087054710366384

Journal of attention disorders

J Atten Disord

Alerting, orienting, and executive attention in children with ADHD.

This study evaluated the alerting, orienting, and executive attention abilities of children with ADHD and their typically developing (TD) peers using a modified version of the adult attention network test (ANT-I). A total of 25 children with ADHD, Combined Type (ADHD-C, mean age = 9.20 years), 20 children with ADHD, Predominantly Inattentive Type (ADHD-I, mean age = 9.58 years), and 45 TD children (mean age = 9.41 years) matched on age and intelligence to the ADHD group completed the ANT-I. As hypothesized, children with ADHD (n = 45) displayed significantly weaker alerting and executive attention than TD children (n = 45) but did not differ from TD children in orienting ability. Children with ADHD-C (n = 25) did not differ from children with ADHD-I (n = 20) on any of the three networks. Results supported the growing body of evidence that has found alerting and executive attention deficits in children with ADHD.

CognitiveConstruct

ExecutiveAttention

10.1080/17470210903249365

Quarterly journal of experimental psychology (2006)

Q J Exp Psychol (Hove)

Greater efficiency in attentional processing related to mindfulness meditation.

In this study, attentional processing in relation to mindfulness meditation was investigated. Since recent studies have suggested that mindfulness meditation may induce improvements in attentional processing, we have tested 20 expert mindfulness meditators in the attention network test. Their performance was compared to that of 20 age- and gender-matched controls. In addition to attentional network analyses, overall attentional processing was analysed by means of efficiency scores (i.e., accuracy controlled for reaction time). Better orienting and executive attention (reflected by smaller differences in either reaction time or error score, respectively) were observed in the mindfulness meditation group. Furthermore, extensive mindfulness meditation appeared to be related to a reduction of the fraction of errors for responses with the same reaction time. These results provide new insights into differences in attentional processing related to mindfulness meditation and suggest the possibility of increasing the efficiency in attentional processing by extensive mental training.

CognitiveConstruct

ExecutiveAttention

10.1002/art.27497

Arthritis and rheumatism

Arthritis Rheum

Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity.

Fibromyalgia (FM) is considered to be the prototypical central chronic pain syndrome and is associated with widespread pain that fluctuates spontaneously. Multiple studies have demonstrated altered brain activity in these patients. The objective of this study was to investigate the degree of connectivity between multiple brain networks in patients with FM, as well as how activity in these networks correlates with the level of spontaneous pain. Resting-state functional magnetic resonance imaging (FMRI) data from 18 patients with FM and 18 age-matched healthy control subjects were analyzed using dual-regression independent components analysis, which is a data-driven approach for the identification of independent brain networks. Intrinsic, or resting-state, connectivity was evaluated in multiple brain networks: the default mode network (DMN), the executive attention network (EAN), and the medial visual network (MVN), with the MVN serving as a negative control. Spontaneous pain levels were also analyzed for covariance with intrinsic connectivity. Patients with FM had greater connectivity within the DMN and right EAN (corrected P [P(corr)] < 0.05 versus controls), and greater connectivity between the DMN and the insular cortex, which is a brain region known to process evoked pain. Furthermore, greater intensity of spontaneous pain at the time of the FMRI scan correlated with greater intrinsic connectivity between the insula and both the DMN and right EAN (P(corr) < 0.05). These findings indicate that resting brain activity within multiple networks is associated with spontaneous clinical pain in patients with FM. These findings may also have broader implications for how subjective experiences such as pain arise from a complex interplay among multiple brain networks.

CognitiveConstruct

ExecutiveAttention

10.1027/1618-3169/a000073

Experimental psychology

Exp Psychol

Accessory stimuli affect the emergence of conflict, not conflict control.

Accessory signals that precede stimuli in interference tasks lead to faster overall responses while conflict increases. Two opposing accounts exist for the latter finding: one is based on dual-route frameworks of response preparation and proposes amplification of both direct response activation and indirect response selection processes; the other refers to attentional networks and suggests inhibition of executive attention, thereby hampering conflict control. The present study replicated previous behavioral findings in a Simon task and extended them by electrophysiological evidence. Accessory tones facilitated stimulus classification and attentional allocation in the Simon task as reflected by an increased N1 amplitude and an overall decrease of the N2 amplitude, respectively. The conflict-related N2 amplitude, which is larger in conflict trials compared with nonconflict trials, was not modulated by accessory tones. Moreover, accessory tones did not affect sequence-dependent conflict adaptation. In terms of a dual-route framework present results suggest amplification of both response preparation routes by accessory stimuli. An executive attention approach proposing accessory stimuli to hamper control of conflict is not supported.

CognitiveConstruct

ExecutiveAttention

10.1016/j.dcn.2010.12.003

Developmental cognitive neuroscience

Dev Cogn Neurosci

An ERP study of conflict monitoring in 4-8-year old children: associations with temperament.

Although there is great interest in identifying the neural correlates of cognitive processes that create risk for psychopathology, there is a paucity of research in young children. One event-related potential (ERP), the N2, is thought to index conflict monitoring and has been linked cognitive and affective risk factors for anxiety. Most of this research, however, has been conducted with adults, adolescents, and older children, but not with younger children. To address this gap, the current study examined 26 4-8-year-olds, who completed a cued flanker task while EEG was continuously recorded. We assessed whether the N2 was detectable in this group of young children and examined associations between the N2 and factors reflecting affective risk (e.g., reduced executive attention, temperamental effortful control, and temperamental surgency). We documented an N2 effect (greater N2 amplitude to incongruent versus congruent flankers), but only in children older than 6 years of age. Increases in the N2 effect were associated with less efficient executive attention and lower temperamental effortful control. We discuss the implications of these findings and consider how they may inform future studies on biomarkers for cognitive and affective risk factors for anxiety.

CognitiveConstruct

ExecutiveAttention

10.1037/a0017619

Neuropsychology

Neuropsychology

The relationship between working memory capacity and executive functioning: evidence for a common executive attention construct.

Attentional control has been conceptualized as executive functioning by neuropsychologists and as working memory capacity by experimental psychologists. We examined the relationship between these constructs using a factor analytic approach in an adult life span sample. Several tests of working memory capacity and executive function were administered to more than 200 subjects between 18 and 90 years of age, along with tests of processing speed and episodic memory. The correlation between working memory capacity and executive functioning constructs was very strong (r = .97), but correlations between these constructs and processing speed were considerably weaker (rs approximately .79). Controlling for working memory capacity and executive function eliminated age effects on episodic memory, and working memory capacity and executive function accounted for variance in episodic memory beyond that accounted for by processing speed. We conclude that tests of working memory capacity and executive function share a common underlying executive attention component that is strongly predictive of higher level cognition.

CognitiveConstruct

ExecutiveAttention

10.1017/S1355617709991391

Journal of the International Neuropsychological Society : JINS

J Int Neuropsychol Soc

Learning and memory in amnestic mild cognitive impairment: contribution of working memory.

In addition to deficits in delayed recall, recent research suggests that participants with amnestic mild cognitive impairment (aMCI) demonstrate diminished use of strategic encoding strategies during learning. Few studies have explored the cognitive mechanisms underlying this deficit. The aim of this study was to investigate in aMCI whether components of working memory (executive attention--attention set-shifting, dividing and focusing attention; and episodic buffer functions--strategic retrieval and manipulation of information) predict strategic encoding strategies during learning (semantic clustering). Thirty-three participants with aMCI and 33 healthy older adults (HOA) were administered neuropsychological tests assessing word-list learning and working memory. The aMCI group demonstrated significant impairment in acquisition, retrieval of information, and decreased use of semantic clustering strategies. Use of semantic clustering in the aMCI group was not predicted by measures of executive attention or phonemic verbal fluency, but was predicted by semantic verbal fluency performance. In the HOA group, semantic clustering was strongly related to semantic verbal fluency. These findings suggest that in aMCI, diminished strategic encoding strategies during learning (semantic clustering) is selectively related to the strategic function of the episodic buffer, but only when in interaction with the manipulation and retrieval of semantic associations.

CognitiveConstruct

ExecutiveAttention

10.1016/j.plrev.2009.02.001

Physics of life reviews

Phys Life Rev

Toward a physical basis of attention and self regulation.

The concept of self-regulation is central to the understanding of human development. Self-regulation allows effective socialization and predicts both psychological pathologies and levels of achievement in schools. What has been missing are neural mechanisms to provide understanding of the cellular and molecular basis for self-regulation. We show that self-regulation can be measured during childhood by parental reports and by self-reports of adolescents and adults. These reports are summarized by a higher order factor called effortful control, which reflects perceptions about the ability of a given person to regulate their behavior in accord with cultural norms. Throughout childhood effortful control is related to children's performance in computerized conflict related tasks. Conflict tasks have been shown in neuroimaging studies to activate specific brain networks of executive attention. Several brain areas work together at rest and during cognitive tasks to regulate competing brain activity and thus control resulting behavior. The cellular structure of the anterior cingulate and insula contain cells, unique to humans and higher primates that provide strong links to remote brain areas. During conflict tasks, anterior cingulate activity is correlated with activity in remote sensory and emotional systems, depending upon the information selected for the task. During adolescence the structure and activity of the anterior cingulate has been found to be correlated with self-reports of effortful control.Studies have provided a perspective on how genes and environment act to shape the executive attention network, providing a physical basis for self-regulation. The anterior cingulate is regulated by dopamine. Genes that influence dopamine levels in the CNS have been shown to influence the efficiency of self-regulation. For example, alleles of the COMT gene that influence the efficiency of dopamine transmission are related to the ability to resolve conflict. Humans with disorders involving deletion of this gene exhibit large deficits in self-regulation. Alleles of other genes influencing dopamine and serotonin transmission have also been found to influence ability to resolve conflict in cognitive tasks. However, as is the case for many genes, the effectiveness of COMT alleles in shaping self-regulation depends upon cultural influences such as parenting. Studies find that aspects of parenting quality and parent training can influence child behavior and the efficiency of self-regulation.During development, the network that relates to self-regulation undergoes important changes in connectivity. Infants can use parts of the self-regulatory network to detect errors in sensory information, but the network does not yet have sufficient connectivity to organize brain activity in a coherent way. During middle childhood, along with increased projection cells involved in remote connections of dorsal anterior cingulate and prefrontal and parietal cortex, executive network connectivity increases and shifts from predominantly short to longer range connections. During this period specific exercises can influence network development and improve self-regulation. Understanding the physical basis of self-regulation has already cast light on individual differences in normal and pathological states and gives promise of allowing the design of methods to improve aspects of human development.

CognitiveConstruct

ExecutiveAttention

10.1159/000275672

Dementia and geriatric cognitive disorders

Dement Geriatr Cogn Disord

Attention network functioning in patients with dementia with Lewy bodies and Alzheimer's disease.

Attention deficits are at the core of the defects in neuropsychological performance which define both dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Most studies have used separate tasks to test different attention abilities in patients with these diagnoses, precluding the assessment of any interaction among the different attention components. We used a version of the Attention Network Test in which the alerting, orienting and executive attention networks, along with their interactions, could be assessed with a single task. Three groups of participants were tested: DLB patients (n = 13), AD patients (n = 18) and healthy controls (n = 18). The alerting signal improved orienting attention and increased the conflict effect in the healthy controls, but they had no effect on these networks in the AD patients. The DLB patients only showed preserved orienting and conflict effects when the alerting signal was present, indicating that there was regulation of the orienting and executive attention networks by the alerting signal. The most important differences among the 3 groups were observed in the attention network interactions, where alerting played a more relevant role in the DLB than in the AD patients. Under alerting states, the DLB patients showed evidence of certain regulation in the orienting and executive attention networks.

CognitiveConstruct

ExecutiveAttention

10.1002/hbm.20924

Human brain mapping

Hum Brain Mapp

Biasing the organism for novelty: A pervasive property of the attention system.

Although the functional and anatomical independences between the orienting and the executive attention networks have been well established, surprisingly little is known about the potential neural interaction between them. Recent studies point out that spatial inhibition of return (IOR), a mechanism associated with the orienting network, and nonspatial inhibition of return, a mechanism associated with the executive network, might bias the organism for novel locations and objects, respectively. By orthogonally combining the spatial and the nonspatial IOR paradigms in this fMRI study, we demonstrate that the orienting and the executive networks interact and compensate each other in biasing the attention system for novelty. Behaviorally, participants responded slower to the target at the old location only when the color of the target was novel, and participants responded slower to the old color representation only when the target appeared at a novel spatial location. Neurally, the orienting network was involved in slowing down responses to the old location only when the nonspatial IOR mechanism in the executive network was not operative (i.e., when the color of the target was novel); the prefrontal executive network was involved in slowing down responses to the old color representation only when the spatial IOR mechanism in the orienting network was not functioning (i.e., when the target appeared at a novel location).

CognitiveConstruct

ExecutiveAttention

10.1111/j.1469-8749.2009.03560.x

Developmental medicine and child neurology

Dev Med Child Neurol

Predictive validity of attentional functions in differentiating children with and without ADHD: a componential analysis.

The objective of this study was to investigate which attentional components are of predictive utility in differentiating children with attention-deficit-hyperactivity disorder, combined type (ADHD-C) from their peers without ADHD. Thirty-four children participated in the study: 17 males with ADHD-C (mean age 10y 4mo, SD 1y 9mo) and 17 comparison children (12 males, 5 females; mean age 10y 8mo, SD 1.7y). Attentional functions were assessed using a computer-administered, child-friendly test series in German (i.e. Testbatterie zur Aufmerksamkeitsprüfung für Kinder; KITAP). The KITAP measures several attentional components, including alertness and executive attention (inhibition, divided attention, flexibility). The variable best able to discriminate between children with and without ADHD-C was found to be response time variability in a go/no go task, followed by, in order, number of errors in a divided attention task and response time variability in an alertness task. However, group discrimination was not facilitated by differences in either response latency or accuracy of response in visuospatial attention and attentional flexibility tasks. The assessment of attentional functions proved to be a powerful instrument for discriminating between children with and without ADHD-C. Notably, the discriminative power of executive attention was found to be task dependent and dependent on processing demands.

CognitiveConstruct

ExecutiveAttention

10.1371/journal.pone.0008469

PloS one

PLoS One

Neurological soft signs and their relationships to neurocognitive functions: a re-visit with the structural equation modeling design.

Neurological soft signs and neurocognitive impairments have long been considered important features of schizophrenia. Previous correlational studies have suggested that there is a significant relationship between neurological soft signs and neurocognitive functions. The purpose of the current study was to examine the underlying relationships between these two distinct constructs with structural equation modeling (SEM). 118 patients with schizophrenia and 160 healthy controls were recruited for the current study. The abridged version of the Cambridge Neurological Inventory (CNI) and a set of neurocognitive function tests were administered to all participants. SEM was then conducted independently in these two samples to examine the relationships between neurological soft signs and neurocognitive functions. Both the measurement and structural models showed that the models fit well to the data in both patients and healthy controls. The structural equations also showed that there were modest to moderate associations among neurological soft signs, executive attention, verbal memory, and visual memory, while the healthy controls showed more limited associations. The current findings indicate that motor coordination, sensory integration, and disinhibition contribute to the latent construct of neurological soft signs, whereas the subset of neurocognitive function tests contribute to the latent constructs of executive attention, verbal memory, and visual memory in the present sample. Greater evidence of neurological soft signs is associated with more severe impairment of executive attention and memory functions. Clinical and theoretical implications of the model findings are discussed.

CognitiveConstruct

ExecutiveAttention

10.1016/j.alcohol.2009.10.009

Alcohol (Fayetteville, N.Y.)

Alcohol

A neurodevelopmental framework for the development of interventions for children with fetal alcohol spectrum disorders.

Despite considerable data published on cognitive and behavioral disabilities in children with fetal alcohol spectrum disorders (FASD), relatively little information is available on behavioral or pharmacological interventions for alcohol-affected children. The main goals of this article, therefore, are to summarize published intervention studies of FASD and to present a neurodevelopmental framework, based on recent findings from a number of disciplines, for designing new therapies for alcohol-affected children. This framework assumes a neuroconstructionist view, which posits that reciprocal interactions between neural activity and the brain's hardware lead to the progressive formation of intra- and interregional neural connections. In this view, behavioral interventions can be conceptualized as a series of guided experiences that are designed to produce neural activation. Based on evidence from cognitive neuroscience, it is hypothesized that specific interventions targeting executive attention and self-regulation may produce greater generalizable results than those aimed at domain-specific skills in children with FASD. In view of reciprocal interactions between environmental effects and neural structures, the proposed framework suggests that the maximum effects of interventions can eventually be achieved by optimally combining behavioral methods and cognition-enhancing drugs.

CognitiveConstruct

ExecutiveAttention

10.1017/S1355617709990488

Journal of the International Neuropsychological Society : JINS

J Int Neuropsychol Soc

The influence of pre-deployment neurocognitive functioning on post-deployment PTSD symptom outcomes among Iraq-deployed Army soldiers.

This study evaluated associations between pre-deployment neurocognitive performance and post-deployment posttraumatic stress disorder (PTSD) symptoms in a sample of deployed active duty Army soldiers. As part of a larger longitudinal study, each participant completed baseline measures of memory, executive attention, and response inhibition, and baseline and post-deployment self-report measures of PTSD symptom severity. Data were subjected to multiple regression analyses that examined associations between baseline neurocognitive performances and longitudinal PTSD symptom outcome. Results revealed that pre-trauma immediate recall of visual information was associated with post-deployment PTSD symptom severity, even after controlling for pre-deployment PTSD symptom levels, combat intensity, age, gender, and test-retest interval. There was also an interaction between pre-deployment PTSD symptom severity and pre-deployment immediate visual recall and verbal learning, indicating that neurocognitive performances were more strongly (and negatively) associated with residualized post-deployment PTSD symptoms at higher levels of pre-deployment PTSD symptoms. These findings highlight the potential role of pre-trauma neurocognitive functioning in moderating the effects of trauma exposure on PTSD symptoms

CognitiveConstruct

ExecutiveAttention

10.1186/1744-9081-5-41

Behavioral and brain functions : BBF

Behav Brain Funct

Correlations between measures of executive attention and cortical thickness of left posterior middle frontal gyrus - a dichotic listening study.

The frontal lobe has been associated to a wide range of cognitive control functions and is also vulnerable to degeneration in old age. A recent study by Thomsen and colleagues showed a difference between a young and old sample in grey matter density and activation in the left middle frontal cortex (MFC) and performance on a dichotic listening task. The present study investigated this brain behaviour association within a sample of healthy older individuals, and predicted a positive correlation between performance in a condition requiring executive attention and measures of grey matter structure of the posterior left MFC. A dichotic listening forced attention paradigm was used to measure attention control functions. Subjects were instructed to report only the left or the right ear syllable of a dichotically presented consonant-vowel syllable pair. A conflict situation appears when subjects are instructed to report the left ear stimulus, caused by the conflict with the bottom-up, stimulus-driven right ear advantage. Overcoming this processing conflict was used as a measure of executive attention. Thickness and volumes of frontal lobe regions were derived from automated segmentation of 3D magnetic resonance image acquisitions. The results revealed a statistically significant positive correlation between the thickness measure of the left posterior MFC and performance on the dichotic listening measures of executive attention. Follow-up analyses showed that this correlation was only statistically significant in the subgroup that showed the typical bottom-up, stimulus-driven right ear advantage. The results suggest that the left MFC is a part of an executive attention network, and that the dichotic listening forced attention paradigm may be a feasible tool for assessing subtle attentional dysfunctions in older adults.

CognitiveConstruct

ExecutiveAttention

10.1080/17470210903137180

Quarterly journal of experimental psychology (2006)

Q J Exp Psychol (Hove)

What's on your mind: the influence of the contents of working memory on choice.

Information maintained in working memory (WM) has the potential to bias selective attention and limit executive attention. The current study assessed the influence of information in WM on the tasks one chooses to perform in a multitasking environment. Participants held either identities or locations in WM while performing voluntary task-switching trials on stimuli that did or did not match the information they were attempting to maintain. A bias toward performing the task associated with stimuli that had recently been encoded into WM was found. The results suggest that information in WM can influence choice within a multitasking environment.

CognitiveConstruct

ExecutiveAttention

10.1016/j.rmed.2009.08.008

Respiratory medicine

Respir Med

Impact of chronic obstructive pulmonary disease (COPD) on attention functions.

The present study investigates the influence of COPD on attention functions, learning, and logical thinking. Therefore, 60 COPD patients and 60 healthy controls were recruited into a cross-sectional study and underwent extensive neuropsychological testing. The Attention Network Test was used for assessment of tonic and phasic alertness, orienting, and executive attention. Logical thinking and learning were determined with the Standard Progressive Matrices and the Verbal and Nonverbal Learning Test, respectively. Significant group differences were found in phasic alertness (p=0.001) and orienting (p=0.01) but not in executive attention. In addition overall reaction time was significantly slower in the COPD group (p=0.001). Further group differences were found in verbal (p<0.001) and visual learning (p<0.001) and logical thinking (p<0.001). Regression analysis revealed significant correlations for age (p=0.024) and blood carbon dioxide levels (p=0.043) in reaction time, a correlation for age and orienting (p=0.019) and finally for age (p=0.011) as well as for blood carbon dioxide values (p=0.048) and performance in logical thinking. Results are indicating a global impairment in cognitive functions of COPD patients which is negatively influenced by accelerated aging and increasing with disease severity.

CognitiveConstruct

ExecutiveAttention

10.1055/s-0029-1237117

Seminars in neurology

Semin Neurol

Neurocognitive consequences of sleep deprivation.

Sleep deprivation is associated with considerable social, financial, and health-related costs, in large measure because it produces impaired cognitive performance due to increasing sleep propensity and instability of waking neurobehavioral functions. Cognitive functions particularly affected by sleep loss include psychomotor and cognitive speed, vigilant and executive attention, working memory, and higher cognitive abilities. Chronic sleep-restriction experiments--which model the kind of sleep loss experienced by many individuals with sleep fragmentation and premature sleep curtailment due to disorders and lifestyle--demonstrate that cognitive deficits accumulate to severe levels over time without full awareness by the affected individual. Functional neuroimaging has revealed that frequent and progressively longer cognitive lapses, which are a hallmark of sleep deprivation, involve distributed changes in brain regions including frontal and parietal control areas, secondary sensory processing areas, and thalamic areas. There are robust differences among individuals in the degree of their cognitive vulnerability to sleep loss that may involve differences in prefrontal and parietal cortices, and that may have a basis in genes regulating sleep homeostasis and circadian rhythms. Thus, cognitive deficits believed to be a function of the severity of clinical sleep disturbance may be a product of genetic alleles associated with differential cognitive vulnerability to sleep loss.

CognitiveConstruct

ExecutiveAttention

10.1080/17470210903147486

Quarterly journal of experimental psychology (2006)

Q J Exp Psychol (Hove)

Selection of objects and tasks in working memory.

When people hold several objects (such as digits or words) in working memory and select one for processing, switching to a new object takes longer than selecting the same object as that on the preceding processing step. Similarly, selecting a new task incurs task- switching costs. This work investigates the selection of objects and of tasks in working memory using a combination of object-switching and task-switching paradigms. Participants used spatial cues to select one digit held in working memory and colour cues to select one task (addition or subtraction) to apply to it. Across four experiments the mapping between objects and their cues and the mapping between tasks and their cues were varied orthogonally. When mappings varied from trial to trial for both objects and tasks, switch costs for objects and tasks were additive, as predicted by sequential selection or resource sharing. When at least one mapping was constant across trials, allowing learning of long-term associations, switch costs were underadditive, as predicted by partially parallel selection. The number of objects in working memory affected object-switch costs but not task-switch costs, counter to the notion of a general resource of executive attention.

CognitiveConstruct

ExecutiveAttention

10.1016/S0079-6123(09)17614-8

Progress in brain research

Prog Brain Res

Development of attentional processes in ADHD and normal children.

Attention Deficit Hyperactivity Disorder (ADHD) is a developmental disorder. Typical development of attentional processes is rapid during early childhood. ADHD results in impairment in response inhibition, error monitoring, attentional disengagement, executive attention, and delay aversion and may effect the ongoing development of these processes during childhood. We examined the development of attentional processes in children with ADHD and normal children. Two hundred forty children (120 in each group) in the age range of 6-9 years participated in the study. Four tasks: Stop-Signal, attentional disengagement, attention network, and choice delay task were administered. Stop signal reaction time, switch costs, conflict effect, and percentage choice of short delay reward was higher in ADHD group compared to normal group. Post error of slowing was less in ADHD children. Endogenous orienting effect was more in normal children compared to ADHD children. Different developmental trajectories were observed for control functions in normal children. Major development in response inhibition occurred in 7-8 years, error monitoring in 6-9 years, and attentional disengagement in 7-9 years. Late development in alerting network was observed in normal children at age 9 years. No developmental changes occurred on these control functions in ADHD children aged 6-9 years. Age related changes were observed on delay aversion between 6 and 9 years in normal children, while it changed between 6 and 7 years in ADHD children. Performance was not changed on orienting and conflict attentional networks in both the children except conflict effect reduced between 7 and 9 years in ADHD children under double cue condition. Conflict network was interacted with the alerting and orienting network in normal children; specifically conflict network interacted with the orienting network in younger children (age 6 years) and with alerting network in older children (age 9 years). In ADHD group interaction between alerting and conflict network was observed only in the double cue condition. Together these results indicated that the deficits in control processes accumulate with age in ADHD children Present study favors the conceptual view of ADHD as a stable deficit in cognitive control functions, which are implicated in the pathology of ADHD. These results have theoretical implication for the theories of executive control and ADHD.

CognitiveConstruct

ExecutiveAttention

10.1016/S0079-6123(09)17613-6

Progress in brain research

Prog Brain Res

Attention for action during error correction.

While the role of attention in selecting visual attributes is well acknowledged, relatively less is known about the mechanisms that facilitate the selection of actions during goal-directed behaviors. The notion of an executive attention has provided a particularly fruitful framework to understand how the brain coordinates the selection of appropriate modules in a sequence that optimizes behavior. However, to do this, theorists have recognized the need to parcel out this unitary system into subcomponents. Two modules that have been commonly invoked are performance monitoring and response inhibition. Visuomotor control of eye movements provides an elegant model system to investigate these mechanisms of selection and control specially occurring during "double-step" tasks in which goals are suddenly changed, demanding inhibition and error detection/correction. Here, we describe our work that has focused on the executive mechanisms that regulate the production of saccadic movements during double-step tasks in different cognitive contexts and target-shift double-step tasks. By examining the pattern of response in the context of quantitative models of saccadic reaction times, we provide behavioral evidence of predictive error correction that produces fast, corrective responses. The predictions from these behavioral experiments were also tested and supported by analyzing neural data from the frontal cortex of monkeys performing similar tasks. Finally, we present data that tested the possibility of an interaction between the inhibitory control and error correction and suggest a model in which predictive error correction may be engaged when the likelihood of error is high. We propose that these results when used in conjunction with electrophysiological recordings, may provide an important approach to understand how error detection/correction and inhibition, two vital cogs in the functioning of executive control, may interact to govern goal-directed behaviors.

CognitiveConstruct

ExecutiveAttention

10.1016/j.janxdis.2009.08.005

Journal of anxiety disorders

J Anxiety Disord

The effect of fear on attentional processing in a sample of healthy females.

The present experiment examines the effect of fear on efficiency of three attention networks: executive attention, orienting and alerting, in a healthy female sample. International Affective Picture System (IAPS) images were used to elicit both a fear response and a non-emotional response in 100 participants. During the emotion manipulation, participants performed a modified version of the Attention Network Test (ANT). Results showed enhanced executive attention in the fear condition compared to the control condition. Specifically, during a fear experience participants were better able to inhibit irrelevant information resulting in faster response times to a target. There was no effect of fear on orienting while the effect of fear on alerting was inconclusive. It is suggested that enhanced executive attention in fear-eliciting situations may function to focus attention on a potentially threat-related target, thus facilitating subsequent rapid responding.

CognitiveConstruct

ExecutiveAttention

10.1038/npp.2009.95

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Neuropsychopharmacology

Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion.

Catecholamines, particularly dopamine, have been implicated in various aspects of the reward function including the ability to learn through reinforcement and to modify flexibly responses to changing reinforcement contingencies. We examined the impact of catecholamine depletion (CD) achieved by oral administration of alpha-methyl-paratyrosine (AMPT) on probabilistic reversal learning and passive avoidance (PA) in 15 female subjects with major depressive disorder in full remission (RMDD) and 12 healthy female controls. The CD did not affect significantly the acquisition phase of the reversal learning task. However, CD selectively impaired reversal of the 80-20 contingency pair. In the PA learning task, CD was associated with reduced responding toward rewarding stimuli, although the RMDD and control subjects did not differ regarding these CD-induced changes in reward processing. Interestingly, the performance decrement produced by AMPT on both of these tasks was associated with the level of decreased metabolism in the perigenual anterior cingulate cortex. In an additional examination using the affective Stroop task we found evidence for impaired executive attention as a trait abnormality in MDD. In conclusion, this study showed specific effects of CD on the processing of reward-related stimuli in humans and confirms earlier investigations that show impairments of executive attention as a neuropsychological trait in affective illness.

CognitiveConstruct

ExecutiveAttention

10.1111/j.1467-9280.2009.02415.x

Psychological science

Psychol Sci

Retrieval-induced forgetting and executive control.

Retrieving information from long-term memory can lead people to forget previously irrelevant related information. Some researchers have proposed that this retrieval-induced forgetting (RIF) effect is mediated by inhibitory executive-control mechanisms recruited to overcome interference. We assessed whether inhibition in RIF depends on executive processes. The RIF effect observed in a standard retrieval-practice condition was compared to that observed in two different conditions in which participants had to perform two concurrent updating tasks that demanded executive attention. Whereas the usual RIF effect was observed when retrieval practice was performed singly, no evidence of forgetting was found in the dual-task conditions. Results strongly suggest that inhibition involved in RIF is the result of executive-control processes.

CognitiveConstruct

ExecutiveAttention

10.1080/13546800902844064

Cognitive neuropsychiatry

Cogn Neuropsychiatry

Genetic variation influences on the early development of reactive emotions and their regulation by attention.

Individual differences in temperament and attention provide an important link between normal and pathological development. Previous studies suggest that during infancy, orienting of attention is associated with higher levels of positive affect and lower levels of negative affect. For older children and adults, self-regulation, as measured by ratings of effortful control, is consistently associated with lower levels of negative affect such as sadness and distress. In the current paper we use a longitudinal study of children at ages 6-7 months (Time 1) and 18-20 months (Time 2) to examine how variations in candidate genes relate to emotional and self-regulatory aspects of temperament. In accord with previous findings, parent ratings of orienting were positively related to positive affect only during infancy. Genetic variation in COMT was related to positive affect at Time l but not Time 2. Negative affect at both Time 1 and Time 2 was related to genetic variation in SNAP25. Genetic variation in CHRNA4 was related to Effortful Control at Time 2. These findings lend support to the early modulation of emotion by aspects of orienting (Time 1) and executive attention (Time 2), and indicate that emotional reactivity and its regulation are modulated by different genes.

CognitiveConstruct

ExecutiveAttention

10.1177/1087054709334514

Journal of attention disorders

J Atten Disord

The effect of happiness and sadness on alerting, orienting, and executive attention.

According to the attention network approach, attention is best understood in terms of three functionally and neuroanatomically distinct networks-alerting, orienting, and executive attention. An important question is whether the experience of emotion differentially influences the efficiency of these networks. This study examines 180 participants were randomly assigned to a happy, sad, or control condition and undertook a modified version of the Attention Network Test. The results showed no effect of happiness or sadness on alerting, orienting, or executive attention. However, sad participants showed reduced intrinsic alertness. This suggests that sadness reduces general alertness rather than impairing the efficiency of specific attention networks.

CognitiveConstruct

ExecutiveAttention

10.1002/ajmg.b.30967

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Am J Med Genet B Neuropsychiatr Genet

Familiality and molecular genetics of attention networks in ADHD.

Indices from a more elementary neuropsychological level might be useful in the search for genes for complex psychiatric disorders, such as ADHD. In this study we investigated systematically whether attentional performance as measured with the Attention Network Test (ANT) is suited for the identification of endophenotypes of ADHD. Attentional performance in affected sib pairs with ADHD (n = 181) was compared to unaffected control siblings (n = 121). Intrafamilial correlation patterns were calculated. In addition, linkage and association analyses were conducted between quantitative scores of attentional functions and dopamine receptor D4 (DRD4) and dopamine transporter (DAT1 or SLC6A3) gene variants. Only the executive attention network was significantly impaired in subjects with ADHD compared to controls (P < 0.05) and showed evidence for familiality in both affected and unaffected families. Linkage analyses revealed the highest LOD score for a severity score based on DSM-IV inattentive symptoms in the DAT1 chromosomal region (LOD score 2.6 at 15 cM). However, a SNP (rs6350) at the DAT1 locus showed a tendency for association with both alerting performance (P = 0.02) and executive attention (P = 0.01) although it did not survive alpha adjustment for multiple testing. No evidence was found for association of any of the investigated phenotypes with the VNTR in the DRD4. Thus, our data suggest that the quantitative behavioral ratings of inattentive symptoms might be more useful when searching for new genes associated with ADHD, however, among the ANT measures the executive attention network seems to be best suited for further endophenotype analyses.

CognitiveConstruct

ExecutiveAttention

10.1016/j.neuroscience.2009.01.029

Neuroscience

Neuroscience

Assessing the molecular genetics of the development of executive attention in children: focus on genetic pathways related to the anterior cingulate cortex and dopamine.

It is well known that children show gradual and protracted improvement in an array of behaviors involved in the conscious control of thought and emotion. Non-invasive neuroimaging in developing populations has revealed many neural correlates of behavior, particularly in the developing cingulate cortex and frontostriatal circuits. These brain regions, themselves, undergo protracted molecular and cellular change in the first two decades of human development and, as such, are ideal regions of interest for cognitive- and imaging-genetic studies that seek to link processes at the biochemical and synaptic levels to brain activity and behavior. We review our research to date that employs both adult and child-friendly versions of the attention network task (ANT) in an effort to begin to describe the role of specific genes in the assembly of a functional attention system. Presently, we constrain our predictions for genetic association studies by focusing on the role of the anterior cingulate cortex (ACC) and of dopamine in the development of executive attention.

CognitiveConstruct

ExecutiveAttention

10.1016/j.brat.2009.01.012

Behaviour research and therapy

Behav Res Ther

Effects of anxiety and attention control on processing pictorial and linguistic emotional information.

This study investigated the role of executive attention control in modulating selective processing of emotional information in anxiety. It was hypothesized that the combination of high anxiety and poor attention control would be associated with greater difficulty in ignoring task-irrelevant threat-related information. The study included both faces and words as stimuli. Cognitive interference effects were assessed using two emotional Stroop tasks: one with angry, fearful, happy and neutral faces, and one with threat-related, positive, and neutral words. An objective measure of attention control was obtained from the Attention network task. There were four participant groups with high/low trait anxiety and high/low attention control. Results indicated that the combination of high anxiety and poor attention control was associated with greater cognitive interference by emotional faces (including angry faces), compared to neutral faces. This interference effect was not evident in participants with high anxiety and high attentional control, or in low-anxious individuals. There was no evidence of associations between anxiety, attention control, and the interference effect of emotional words. Results indicate that high anxiety and poor attention control together predict enhanced processing of emotionally salient information, such as angry facial expressions. Implications for models of emotion processing are discussed.

CognitiveConstruct

ExecutiveAttention

10.1037/a0014104

Journal of experimental psychology. Learning, memory, and cognition

J Exp Psychol Learn Mem Cogn

Conducting the train of thought: working memory capacity, goal neglect, and mind wandering in an executive-control task.

On the basis of the executive-attention theory of working memory capacity (WMC; e.g., M. J. Kane, A. R. A. Conway, D. Z. Hambrick, & R. W. Engle, 2007), the authors tested the relations among WMC, mind wandering, and goal neglect in a sustained attention to response task (SART; a go/no-go task). In 3 SART versions, making conceptual versus perceptual processing demands, subjects periodically indicated their thought content when probed following rare no-go targets. SART processing demands did not affect mind-wandering rates, but mind-wandering rates varied with WMC and predicted goal-neglect errors in the task; furthermore, mind-wandering rates partially mediated the WMC-SART relation, indicating that WMC-related differences in goal neglect were due, in part, to variation in the control of conscious thought.

CognitiveConstruct

ExecutiveAttention

10.1080/00207450802480325

The International journal of neuroscience

Int J Neurosci

Differentiating a network of executive attention: LORETA neurofeedback in anterior cingulate and dorsolateral prefrontal cortices.

This study examines the differential effects of space-specific neuro-operant learning, utilizing low-resolution electromagnetic tomographic (LORETA) neurofeedback in three regions of training (ROTs), namely, the anterior cingulate gyrus (AC) and right and left dorsolateral prefrontal cortices (RPFC and LPFC respectively). This study was conducted with 14 nonclinical students with a mean age of 22. We utilized electrophysiological measurements and subtests of the WAIS-III for premeasures and postmeasures. The data indicate that the AC shares a significant association with the RPFC and LPFC; however, each of the ROTs exhibits different cortical effects in all frequencies when trained exclusively. LORETA neurofeedback (LNFB) appears to enhance the functioning and strengthening of networks of cortical units physiologically related to each ROT; moreover, significant changes are mapped for each frequency domain, showing the associations within this possible attentional network.

CognitiveConstruct

ExecutiveAttention

Hospitals & health networks

Hosp Health Netw

Data page: infection control programs get executive attention.

CognitiveConstruct

ExecutiveAttention

10.1016/j.concog.2008.10.002

Consciousness and cognition

Conscious Cogn

Excessive daydreaming: a case history and discussion of mind wandering and high fantasy proneness.

This case study describes a patient presenting with a long history of excessive daydreaming which has caused her distress but is not incident to any other apparent clinical psychiatric disorders. We have treated this patient for over 10 years, and she has responded favorably to fluvoxamine therapy, stating that it helps to control her daydreaming. Our patient, and other psychotherpists, have brought to our attention other possible cases of excessive daydreaming. We examine the available literature regarding daydreaming, mind wandering, and fantasy proneness relative to current cognitive and neuroanatomical models of executive attention.

CognitiveConstruct

ExecutiveAttention

10.1007/s10802-008-9288-7

Journal of abnormal child psychology

J Abnorm Child Psychol

ERP correlates of effortful control in children with varying levels of ADHD symptoms.

As effortful control (EC), the self-regulation aspect of temperament, has been argued to play a key role in the normal and psychopathological course of development, research adding to the construct validity of EC is needed. In the current study, interrelations between the temperament construct of EC and the efficiency of the executive attention network, argued to underlie EC, were investigated, using event-related potentials (ERPs). In general, children scoring low on EC questionnaires made more errors of commission in the Go/No-Go task and showed smaller No-Go N2 or No-Go P3 amplitudes, two ERP components related to the executive attention network. The two EC scales (Effortful Control Scale and Attentional Control Scale), used in the current study, were differentially related to the outcome, indicating that they may measure different constructs. No-Go P3 amplitude was noted to be associated more strongly with EC than No-Go N2 amplitude. EC was found to be implicated in Attention-Deficit Hyperactivity Disorder (ADHD) symptomatology, as children scoring high on ADHD symptoms scored low on EC questionnaires, made more errors of commission, and showed smaller No-Go P3 amplitudes.

CognitiveConstruct

ExecutiveAttention

10.1093/schbul/sbn118

Schizophrenia bulletin

Schizophr Bull

Impaired modulation of attention and emotion in schizophrenia.

Fronto-limbic interactions facilitate the generation of task-relevant responses while inhibiting interference from emotionally distracting information. Schizophrenia is associated with deficits in both executive attention and affective regulation. This study aims to elucidate the neural correlates of emotion-attention regulation and shifting in schizophrenia. We employed functional magnetic resonance imaging to probe the fronto-limbic regions in 16 adults with schizophrenia and 13 matched adults with no history of psychiatric illness. Subjects performed a forced-choice visual oddball task where they detected infrequent target circles embedded in a series of infrequent nontarget aversive and neutral pictures and frequent squares. In control participants, target events activated a dorsal frontoparietal network, whereas these regions were deactivated by aversive stimuli. Conversely, ventral frontolimbic brain regions were activated by aversive stimuli and deactivated by target events. In the patient group, regional hemodynamic timecourses revealed not only reduced activation to target and aversive events in dorsal executive and ventral limbic regions, respectively, but also reduced deactivation to target and aversive stimuli in ventral and dorsal regions, respectively, relative to the control group. Patients further showed reduced spatial extent of activation in the right inferior frontal gyrus during the target and aversive conditions. Activation of the anterior cingulate to aversive images was inversely related to severity of avolition and anhedonia symptoms in the schizophrenia group. These results suggest both frontal and limbic dysfunction in schizophrenia as well as aberrant reciprocal inhibitions between these regions during attention-emotion modulation in this disorder.

CognitiveConstruct

ExecutiveAttention

10.1037/a0013176

Psychology and aging

Psychol Aging

Cognitive resources, valence, and memory retrieval of emotional events in older adults.

In 2 studies with older adults, the authors investigated the effect of executive attention resources on the retrieval of emotional public events. Participants completed a battery of working memory tasks, as a measure of executive attention, and a battery of tasks assessing memory, as well as subjective experiences associated with the retrieval of remote public events. Participants also rated the valence of each public event story. The group-rated valence of the public event stories predicted retrieval and the quality of experiences associated with them, such that emotionally arousing events elicited the highest memory rates and the richest experiences. Furthermore, positive public events elicited the highest memory rates. Executive attention moderated only the relationship between event valence and how participants' associated memories are experienced at retrieval, such that superior executive attention resources predicted richer experiences associated with positive relative to neutral and negative stories. The current results extend previous findings on the effects of aging on emotion regulation, suggesting that cognitive control resources modulate subjective experiences associated with retrieved memories for remote real life events, but not memory retrieval itself.

CognitiveConstruct

ExecutiveAttention

10.3758/mc.36.4.749

Memory & cognition

Mem Cognit

Executive attention and task switching in category learning: evidence for stimulus-dependent representation.

One class of multiple-system models of category learning posits that within a single category-learning task people can learn to utilize different systems with different category representations to classify different stimuli. This is referred to as stimulus-dependent representation (SDR). The use of SDR implies that learners switch from subtask to subtask as trials demand. Thus, the use of SDR can be assessed via slowed response times, following a representation switch. Additionally, the use of SDR requires control of executive attention to keep inactive representations from interfering with the current response. Subjects were given a category learning task composed of one- and two-dimensional substructures. Control of executive attention was measured using a working memory capacity (WMC) task. Subjects most likely to be using SDR showed greater slowing of responses following a substructure switch and a greater correlation between learning performance and WMC. These results provide support for the principle of SDR in category learning and the reliance of SDR on executive attention.

CognitiveConstruct

ExecutiveAttention

10.1016/j.clinph.2008.04.297

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Clin Neurophysiol

Event-related-potential low-resolution brain electromagnetic tomography (ERP-LORETA) suggests decreased energetic resources for cognitive processing in narcolepsy.

Event-related potentials (ERPs) are sensitive measures of both perceptual and cognitive processes. The aim of the present study was to identify brain regions involved in the processes of cognitive dysfunction in narcolepsy by means of ERP tomography. In 17 drug-free patients with narcolepsy and 17 controls, ERPs were recorded (auditory odd-ball paradigm). Latencies, amplitudes and LORETA sources were determined for standard (N1 and P2) and target (N2 and P300) ERP components. Psychometry included measures of mental performance, affect and critical flicker fusion frequency (CFF). In the ERPs patients demonstrated delayed cognitive N2 and P300 components and reduced amplitudes in midline regions, while N1 and P2 components did not differ from controls. LORETA suggested reduced P300 sources bilaterally in the precuneus, the anterior and posterior cingulate gyri, the ventrolateral prefrontal cortex and the parahippocampal gyrus. In psychometry, patients demonstrated deteriorated mood, increased trait anxiety, decreased CFF and a trend toward reduced general verbal memory and psychomotor activity. Narcoleptic patients showed prolonged information processing, as indexed by N2 and P300 latencies and decreased energetic resources for cognitive processing. Electrophysiological aberrations in brain areas related to the 'executive attention network' and the 'limbic system' may contribute to a deterioration in mental performance and mood at the behavioral level.

CognitiveConstruct

ExecutiveAttention

10.1016/j.apmr.2007.10.023

Archives of physical medicine and rehabilitation

Arch Phys Med Rehabil

The interaction between executive attention and postural control in dual-task conditions: children with cerebral palsy.

To investigate the interference between a secondary task and a postural task in children with cerebral palsy (CP). In this exploratory study, a dual-task paradigm was used in which children stood in either a wide or a narrow stance position while simultaneously performing a visual working memory task calibrated to be of equitable attentional demand between groups. Study data were gathered in a university motor control laboratory. Children with CP (n=8; age range, 10-14y) were compared with typically developing older children (n=6; age range, 7-12y), and typically developing young children (n=5; age range, 4-6y). Not applicable. Proficiency in postural control was measured by the range and root mean square of the velocity of center of pressure displacement in the mediolateral and anteroposterior directions, calculated from forceplate data. Accuracy of response was used as a measure of cognitive task performance. Capacity of the executive attention system was determined by assessing visual working memory capacity. Children with CP, like the typically developing young children, were more unstable and had less executive attention capacity compared with older children, and like the typically developing young children, experienced dual-task interference in postural control in both stance positions. Children with ataxic CP also experienced decreased cognitive task performance in narrow stance. In designing therapeutic interventions for children with CP, it would be beneficial for clinicians to assess postural control in both single- and dual-task environments.

CognitiveConstruct

ExecutiveAttention

10.1016/j.infbeh.2008.02.001

Infant behavior & development

Infant Behav Dev

Executive attention and self-regulation in infancy.

This study investigates early executive attention in infancy by studying the relations between infant sequential looking and other behaviors predictive of later self-regulation. One early marker of executive attention development is anticipatory looking, the act of looking to the location of a target prior to its appearance in that location, a process that involves endogenous control of visual orienting. Previous studies have shown that anticipatory looking is positively related to executive attention as assessed by the ability to resolve spatial conflict in 3-4-year-old children. In the current study, anticipatory looking was positively related to cautious behavioral approach in response to non-threatening novel objects in 6- and 7-month-old infants. This finding and previous findings showing the presence of error detection in infancy are consistent with the hypothesis that there is some degree of executive attention in the first year of life. Anticipatory looking was also related to the frequency of distress, to looking away from disturbing stimuli, and to some self-regulatory behaviors. These results may indicate either early attentional regulation of emotion or close relations between early developing fear and later self-regulation. Overall, the results suggest the presence of rudimentary systems of executive attention in infants and support further studies using anticipatory looking as a measure of individual differences in attention in infancy.

CognitiveConstruct

ExecutiveAttention

10.1016/j.infbeh.2007.12.003

Infant behavior & development

Infant Behav Dev

Attention development in infants and preschool children born preterm: a review.

A potential mechanism that can explain preterm children's heightened risk for the development of later cognitive and behavioral problems is attention. Attention is the ability of an infant or child to orient to, to shift between and to maintain focus on events, objects, tasks, and problems in the external world, processes which are all dependent on the functioning of attentional networks in the brain. The aim of this paper is to provide a review of the literature on attention development in children born preterm during the first 4 years of life. First, research examining the differences between preterm and full-term children indicates that early attention development in infants born preterm is less optimal and that these differences increase when infants grow into toddlers. Second, studies investigating individual differences within preterm populations reveal the influence of both biological factors and environmental factors. Third, individual differences in early orienting and sustained attention have been shown to be predictive of later attentional, cognitive and behavioral functioning in children born preterm. The importance of long-term follow-up studies, with a focus on individual developmental trajectories in orienting, sustained and executive attention, is emphasized.

CognitiveConstruct

ExecutiveAttention

Vertex (Buenos Aires, Argentina)

Vertex

[Development of a sensitive neuropsychological battery to foretell the performance in elder's car driving].

The increase in life expectancy move older people to continue driving. Development of sensitive neuropsychological battery to evaluate driving routines. 78 men were received at the Santojanni Hospital, derived by the General Direction of Road Education and licenses of Buenos Aires city (DGEVL) when people were transacting their driving license renovation. Age 64.2 (DS14,0) years and education 7.9 (DS4,5) years. They were evaluated with MMSE, Cognitive Reaction test (TRC); Procedural memory test (TMP); Continuous Performance test (TPC); Trail Making Test (TMT); Stroop (ST); WAIS III Subtests: Digit-Symbol (DS), Search of Symbols (BS); Digits and Construction with cubes (CC); Rey visual Complex Figure (FC); Benton Visual Discrimination test (TB) and Test of transit Signals (DST). Statistical package SPSS 12.0 was used to obtain, descriptive, frequencies and correlations statistics. The most sensitive tests were: FC; TMT; ST; TPC; DS; TRC; TMP signifying impairment in: perceptual organization; visuospatial skills; information processing speed; reaction capacity before decision making; maintained, selective and executive attention and procedural memory, all of them of critical importance in driving and its control in the transit. Alarming ignorance of transit signals was observed. Of 78 subjects, 23.1% renewed their registry; 33,3% renewed but with lower category and sooner next control; 38,5% were not renewed; 3,8% did not return to DGEVL; 1,3% we do not know data.

CognitiveConstruct

ExecutiveAttention

10.1016/j.schres.2007.11.036

Schizophrenia research

Schizophr Res

A 10-13 year follow-up of changes in perception and executive attention in patients with early-onset schizophrenia: a dichotic listening study.

CognitiveConstruct

ExecutiveAttention

10.1093/schbul/sbm155

Schizophrenia bulletin

Schizophr Bull

Executive attention in schizophrenic males and the impact of COMT Val108/158Met genotype on performance on the attention network test.

Executive control of attention in schizophrenia has recently been assessed by means of the Attention Network Test (ANT). In the past, for tasks assessing executive attention, findings in schizophrenia have been contradictory, among others suggesting a lack of increased stimulus interference effects. Attention and executive functioning are substantially influenced by candidate genes of schizophrenia, including the functional single-nucleotide polymorphism catechol-o-methyltransferase (COMT) Val108/158Met, with task-dependent, specific effects of Met allele load on cognitive function. Therefore, we aimed at investigating executive attention in schizophrenic patients (SZP) as compared with healthy controls (HC), and to assess the specific impact of COMT Val108/158Met on executive attention, using ANT. We applied ANT to 63 SZP and 40 HC. We calculated a general linear model to investigate the influence of affection status and the COMT Val108/158Met genotype on executive attention as assessed by the ANT. Multivariate analysis of variance revealed a significant effect of group on executive attention. SZP exhibited smaller conflict effects in the ANT. Met allele load significantly modulated executive attention efficiency, with homozygous Met individuals showing low overall reaction time but increased effects conflicting stimulus information in executive attention. Our data suggest a disease-related dissociation of executive attention with reduced conflict effects in SZP. Furthermore, they support the hypothesis of differential tonic-phasic dopamine activation and specific dopamine level effects in different cognitive tasks, which helps interpreting contradictory findings of Met allele load on cognitive performance. Disease status seems to modulate the impact of COMT Val108/158Met on cognitive performance.

CognitiveConstruct

ExecutiveAttention