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10.1016/j.ridd.2020.103657

Research in developmental disabilities

Res Dev Disabil

Coping strategies among adults with ADHD: The mediational role of attachment relationship patterns.

For adults with attention/hyperactivity disorder (ADHD), research is scarce on their coping with stress (despite studies demonstrating other self-regulation deficits) and their attachment patterns (despite rare research in younger persons with ADHD showing high vulnerability to insecure attachments). Attachment was linked with coping and self-regulation in general populations but not yet in ADHD. This study explored the possible mediational role of attachment patterns in explaining associations between adults' ADHD symptoms and dysregulated coping. Participants comprised 62 adults (32 females, 30 males) ages 21-40 years (M = 27.60, SD = 4.80) in two groups: 31 adults with formally diagnosed ADHD and 31 demographically matched adults without ADHD. Instruments included computerized neuropsychological tests (sustained/executive attention) and self-reports (ADHD, coping, attachment). Disorder status was verified via ADHD-symptom self-reports and computerized testing. Preliminary analyses revealed significant intergroup differences on coping strategies and attachment. PROCESS analyses (Hayes, 2013) pinpointed attachment measures' mediating role (especially attachment anxiety) regarding ADHD's association with coping. Significantly more maladaptive attachment and coping outcomes emerged for adults with ADHD than controls. Attachment insecurity's role in mediating ADHD's association with coping was partially supported. Possible unique adaptive value of attachment relationships was discussed for coping with stressors in adulthood with ADHD.

CognitiveConstruct

ExecutiveAttention

The New Zealand medical journal

N Z Med J

Ability of the Maze Navigation Test, Montreal Cognitive Assessment, and Trail Making Tests A & B to predict on-road driving performance in current drivers diagnosed with dementia.

This study aimed to evaluate the ability of the Maze Navigation Test (MNT), Montreal Cognitive Assessment (MoCA) and Trail Making Tests A & B (TMT A & B) to predict on-road driving performance in current drivers diagnosed with dementia. Current drivers with a diagnosis of dementia in whom there were clinical concerns about their driving safety were invited to participate between December 2014 and February 2018. Participants completed the MNT, MoCA and TMT A & B, then underwent a blinded specialist Occupational Therapy & Rehabilitation Service (OTRS) off-road and on-road driving assessment. Of the 34 participants, 19 (55.9%) retained their full license and 15 (44.1%) received driving restrictions (including cessation). Only completion time for the MNT (AUC .737, p=.019), the MoCA domain of attention (AUC .809, p=.003) and a combination of the MoCA domain of attention and visuospatial/executive (AUC .783, p=.006) predicted outcome. Derived optimal cut-scores were <443s for MNT completion time (sensitivity 73.3%, specificity 68.4%), <5/6 for MoCA-attention (sensitivity 73.3%, specificity 72.2%) and <8/11 for MoCA-visuospatial/executive+attention (sensitivity 80%, specificity 66.7%). Using these derived cut-scores, MNT completion time predicted poor performance during the on-road assessment in the domains of speed control (p=.039), planning/judgement (p=.004) and vehicle position (p=.028). Results of this study indicate MNT completion time and the MoCA domains of attention and visuospatial/executive could be used to inform driving ability and further referral for a specialist driving assessment.

CognitiveConstruct

ExecutiveAttention

10.1038/s41598-020-63296-x

Scientific reports

Sci Rep

The SLC6A3 gene polymorphism is related to the development of attentional functions but not to ADHD.

Neuropharmacological and human clinical studies have suggested that the brain dopaminergic system is substantively involved in normal and pathological phenotypes of attention. Dopamine transporter gene (SLC6A3) was proposed as a candidate gene for Attention-Deficit/Hyperactivity Disorder (ADHD). We investigated the effect of the SLC6A3 variants on cognitive performance in ADHD and healthy children and teenagers. Participants completed cognitive tasks measuring attentional switching, selective and sustained attention, and effectiveness of alerting, orienting and executive attention. We estimated the effects of 40 bp variable number of tandem repeat (VNTR) polymorphism located in the 3' untranslated region (3' UTR) (9-repeat vs 10-repeat allele) of the SLC6A3 gene, ADHD diagnosis, age, and their interactions as predictors of cognitive performance. ADHD children demonstrated deficits in most of the examined attention processes, persistent within the examined age range (9-16 years). No significant effects were observed for the interaction of ADHD and the SLC6A3 polymorphism, but the results revealed a significant main effect of SLC6A3 genotype in the entire research sample. Subjects carrying 9R allele performed the switching task significantly worse in comparison to children with 10R/10R or 10R/11R genotype. SLC6A3 polymorphism moderated age-related improvements in orienting and attentional switching. Results suggest that SLC6A3 genotype influence these attentional/cognitive functions which deficits are not the key symptoms in ADHD.

CognitiveConstruct

ExecutiveAttention

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

J Tradit Chin Med

Neuropsychological features in post-stroke cognitive impairment with no dementia patients with different Traditional Chinese Medicine syndromes.

To investigate neuropsychological features of post-stroke cognitive impairment with no dementia (PSCIND) patients with different Traditional Chinese Medicine (TCM) syndromes. We recruited 50 patients with PSCIND between April 2012 and March 2013. Patients were divided into different groups according to TCM classifications. Patients were assessed using neuropsychological tests, including cognitive screening (mini-mental state examination), memory testing (auditory verbal learning test), executive/attention [shape trails test, stroop color-word test (SCWT), reading the mind in the eyes test, the digit ordering test-A (DOT-A), and symbol digit modalities test], language (action naming test, Boston naming test, famous face test, similarity test, and verbal fluency test), and visuospatial functioning [complex figure test (CFT)]. We found no significant differences between patients with and without a diagnosis of turbid phlegm blocking the upper orifices on neuropsychological test performance. Patients diagnosed with upper hyperactivity of liver Yang syndrome scored significantly lower on the SCWT-C executive test and the CFT-delayed recall memory test. Patients with excess syndrome scored significantly lower on the SCWT-C executive test, and significantly higher on the DOT-A executive test. Neuropsychological characteristics differ between PSCIND patients with different TCM classifications.

CognitiveConstruct

ExecutiveAttention

10.3390/brainsci10030145

Brain sciences

Brain Sci

The Relation between Sustained Attention and Incidental and Intentional Object-Location Memory.

The role of attention allocation in object-location memory has been widely studied through incidental and intentional encoding conditions. However, the relation between sustained attention and memory encoding processes has scarcely been studied. The present study aimed to investigate performance differences across incidental and intentional encoding conditions using a divided attention paradigm. Furthermore, the study aimed to examine the relation between sustained attention and incidental and intentional object-location memory performance. Based on previous findings, an all women sample was recruited in order to best illuminate the potential effects of interest. Forty-nine women participated in the study and completed the psychomotor vigilance test, as well as object-location memory tests, under both incidental and intentional encoding divided attention conditions. Performance was higher in the incidental encoding condition than in the intentional encoding condition. Furthermore, sustained attention correlated with incidental, but not with intentional memory performance. These findings are discussed in light of the automaticity hypothesis, specifically as it regards the role of attention allocation in encoding object-location memory. Furthermore, the role of sustained attention in incidental memory performance is discussed in light of previous animal and human studies that have examined the brain regions involved in these cognitive processes. We conclude that under conditions of increased mental demand, executive attention is associated with incidental, but not with intentional encoding, thus identifying the exact conditions under which executive attention influence memory performance.

CognitiveConstruct

ExecutiveAttention

10.1093/arclin/acaa014

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Arch Clin Neuropsychol

Predictors of Heterogeneity in Cognitive Function: APOE-e4, Sex, Education, Depression, and Vascular Risk.

Mild cognitive impairment and dementia are clinically heterogeneous disorders influenced by diverse risk factors. Improved characterization of the effect of multiple risk factors influence on specific cognitive functions may improve understanding of mechanisms in early cognitive change and lead to more effective interventions. Structural equation modeling (SEM) simultaneously examined the effects of modifiable (education, depression, and metabolic/vascular risk) and nonmodifiable risk factors (age, sex, and apolipoprotein E-ɛ4 allele [APOE-e4] status) on specific cognitive domains in 461 cognitively normal older adults. The hypothesized model(s) provided an adequate fit for the data. Sex differences in cognition, depression, and vascular risk were found. On average, men were higher in vascular risk with generally lower cognitive performance than women; women were more likely to have depression. APOE-e4 associated with depression but not age, sex, or metabolic/vascular risk. Depression associated with lower executive attention, memory, and language performance, whereas metabolic/vascular risk associated with lower executive attention, memory, and working memory. Older age and lower education are associated with worse performance across the cognitive domains. The combined risk factors accounted for 16%-47% of the variance in the cognitive domains. Results highlight the combined effect of risk factors on cognitive function. Future research is needed to determine whether the multifactorial risk effects on cognition vary by sex. Precision medicine approaches that integrate neuropsychological services may improve diagnostic accuracy and earlier identification of those at risk of cognitive decline.

CognitiveConstruct

ExecutiveAttention

10.3389/fpsyg.2019.03073

Frontiers in psychology

Front Psychol

Enhanced Attentional Network by Short-Term Intensive Meditation.

While recent studies have suggested behavioral effects of short-term meditation on the executive attentional functions, functional changes in the neural correlates of attentional networks after short-term meditation have been unspecified. Here, we conducted a randomized control trial to investigate the effects of a 4-day intensive meditation on the neural correlates of three attentional functions: alerting, orienting, and executive attention. Twenty-three participants in meditation practice and 14 participants in a relaxation retreat group performed attention network test (ANT) during functional magnetic resonance imaging both before and immediately after intervention. The meditation group showed significantly improved behavioral performance in the executive control network in ANT after the intervention. Moreover, neural activities in the executive control network, namely, the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC), were also significantly increased during the ANT after meditation. Interestingly, neural activity in the right ACC was significantly predicted by behavioral conflict levels in each individual in the meditation group, indicating significant effects of the program on the executive control network. Moreover, brain regions associated with the alerting and orienting networks also showed enhanced activity during the ANT after the meditation. Our study provides novel evidence on the enhancement of the attentional networks at the neural level via short-term meditation. We also suggest that short-term meditation may be beneficial to individuals at high risk of cognitive deficits by improving neural mechanisms of attention.

CognitiveConstruct

ExecutiveAttention

10.1038/s41598-020-58787-w

Scientific reports

Sci Rep

EEG microstates associated with intra- and inter-subject alpha variability.

Variation of the magnitude of posterior alpha rhythm (8-12 Hz) has functional and behavioural effects in sensory processing and cognitive performances. Electrical brain activity, as revealed by electroencephalography (EEG), can be represented by a sequence of microstates of about 40-120 ms duration, in which distributed neural pools are synchronously active and generate stable spatial potential topographies on the scalp. Microstate dynamics may reflect transitions between global states characterized by selective inhibition of specific intra-cortical regions, mediated by alpha activity. We investigated the intra-subject and inter-subject relationship between microstate features and alpha band. High-density EEG signals were acquired in 29 healthy subjects during ten minutes of eyes closed rest. Individual EEG signal epochs were classified into four groups depending on the amount of occipital alpha power, and microstate metrics (duration, coverage and frequency of occurrence) were calculated and compared across groups. Correlations between alpha power and microstate metrics between individuals were also performed. To assess if microstate parameter variations are specific for the alpha band, the same analysis was also performed for theta and beta bands, as well as for global field power. We observed an increase in the metrics of microstate, previously associated to the visual system, with the level of intra-subject amplitude alpha oscillations, together with lower coverage of microstate associated with executive attention network and a higher frequency of microstate associated with task negative network. Other modulation effects of broad-band EEG power level on microstate metrics were observed. These effects are not specific for the alpha band, since they can equally be attributed to fluctuations in other frequency bands. We can interpret our results as a regulation mechanism mediated by posterior alpha level, dynamically interacting with other frequency bands, responsible for the switching between active areas.

CognitiveConstruct

ExecutiveAttention

10.1097/AUD.0000000000000830

Ear and hearing

Ear Hear

Audiovisual Enhancement of Speech Perception in Noise by School-Age Children Who Are Hard of Hearing.

The purpose of this study was to examine age- and hearing-related differences in school-age children's benefit from visual speech cues. The study addressed three questions: (1) Do age and hearing loss affect degree of audiovisual (AV) speech enhancement in school-age children? (2) Are there age- and hearing-related differences in the mechanisms underlying AV speech enhancement in school-age children? (3) What cognitive and linguistic variables predict individual differences in AV benefit among school-age children? Forty-eight children between 6 and 13 years of age (19 with mild to severe sensorineural hearing loss; 29 with normal hearing) and 14 adults with normal hearing completed measures of auditory and AV syllable detection and/or sentence recognition in a two-talker masker type and a spectrally matched noise. Children also completed standardized behavioral measures of receptive vocabulary, visuospatial working memory, and executive attention. Mixed linear modeling was used to examine effects of modality, listener group, and masker on sentence recognition accuracy and syllable detection thresholds. Pearson correlations were used to examine the relationship between individual differences in children's AV enhancement (AV-auditory-only) and age, vocabulary, working memory, executive attention, and degree of hearing loss. Significant AV enhancement was observed across all tasks, masker types, and listener groups. AV enhancement of sentence recognition was similar across maskers, but children with normal hearing exhibited less AV enhancement of sentence recognition than adults with normal hearing and children with hearing loss. AV enhancement of syllable detection was greater in the two-talker masker than the noise masker, but did not vary significantly across listener groups. Degree of hearing loss positively correlated with individual differences in AV benefit on the sentence recognition task in noise, but not on the detection task. None of the cognitive and linguistic variables correlated with individual differences in AV enhancement of syllable detection or sentence recognition. Although AV benefit to syllable detection results from the use of visual speech to increase temporal expectancy, AV benefit to sentence recognition requires that an observer extracts phonetic information from the visual speech signal. The findings from this study suggest that all listener groups were equally good at using temporal cues in visual speech to detect auditory speech, but that adults with normal hearing and children with hearing loss were better than children with normal hearing at extracting phonetic information from the visual signal and/or using visual speech information to access phonetic/lexical representations in long-term memory. These results suggest that standard, auditory-only clinical speech recognition measures likely underestimate real-world speech recognition skills of children with mild to severe hearing loss.

CognitiveConstruct

ExecutiveAttention

10.1089/whr.2019.0011

Women's health reports (New Rochelle, N.Y.)

Womens Health Rep (New Rochelle)

Iron Deficiency in Menstruating Adult Women: Much More than Anemia.

Iron deficiency anemia (IDA) is highly prevalent in women of child-bearing age. However, their nonhematological symptoms have been overlooked. This study aims to analyze the nonhematological features and symptoms of IDA in a group of women of reproductive age and the changes occurred during iron therapy. IDA women underwent dietary, physical activity, menstrual blood loss, and cognitive function assessment at baseline. Hematological and biochemical parameters were analyzed. Executive attention was tested by the flanker task and working memory by the 2-back task. Oral iron therapy (ferrous sulfate) was given to 35 women for 8 weeks and the changes in iron status, biochemical markers, cognitive function, and nonhematological symptoms were evaluated. Patients presented nonhematological symptoms: pica, 32.4%; cheilitis, 20.6%; restless legs syndrome (RLS), 20.6%; diffuse hair loss, 55.9%; and ungual alterations, 38.2%. Two or more symptoms were present in 58.8% of women. Serum iron and working memory were correlated at baseline. Multivariate analyses show associations (odds ratio [OR], 95% confidence interval [CI]) between pica and reaction time in the working memory test (OR 2.14, 95% CI 1.19-3.87,  = 0.012); RLS with total serum protein (OR 0.08, 95% CI 0.06-0.92,  = 0.043); and cheilitis with mean corpuscular hemoglobin (OR 0.388, 95% CI 0.189-0.799,  = 0.01). Pica, cheilitis, and RLS completely resolved with iron therapy, and ungual alterations and hair loss improved in 92.3% and 84.2% of women, respectively. Better performance in executive attention and working memory was observed after iron therapy. More attention should be given to the nonhematological manifestations of IDA to improve the quality of life of menstruating women.

CognitiveConstruct

ExecutiveAttention

10.1080/13825585.2020.1715336

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn

Aging in cognitive control of social processing: evidence from the attention network test.

Aging seems to be associated with impairment of attentional network functioning. It is not known whether social information can modulate this age-related decline. We used three variants of Attention Network test to examine the age-related decline of attentional effects in response to stimuli with and without social-cognitive content. Three groups of younger, middle-aged, and older participants performed the ANT, using fish, drawings, or photographs of faces looking to the left or right as target and flanker stimuli. The results showed that both executive attention and alerting were more resistant to the age-related decline with social stimuli and that orienting attention scores showed a progressive increase with age in the presence of this kind of stimuli. These findings underline the importance of social information in modulating and contrasting the age-related decline and support the status of human faces as a special class of visual stimuli for the human attentional systems.

CognitiveConstruct

ExecutiveAttention

10.3390/ijerph16245136

International journal of environmental research and public health

Int J Environ Res Public Health

Device-Measured Sedentary Behavior, Physical Activity and Aerobic Fitness Are Independent Correlates of Cognitive Performance in Healthy Middle-Aged Adults-Results from the SCAPIS Pilot Study.

High aerobic fitness, more moderate to vigorous physical activity (MVPA) and less sedentary behavior (SED) have all been suggested to promote cognitive functions, but it is unclear whether they are independent predictors of specific cognitive domains. This study aimed to investigate to what extent aerobic fitness MVPA and SED are independently associated with cognitive performance among middle-aged Swedish adults. We acquired device-based measures of aerobic fitness, cognitive performance and percent daily time spent in MVPA and SED in Swedish adults ( = 216; 54-66 years old). Aerobic fitness was associated with better performance at one out of two tests of speed/attention and one out of four tests of executive attention, and with worse performance at one of seven tests of memory. Increasing %MVPA was associated with better performance at one out of seven tests of memory and two out of three tests of verbal ability, whereas increasing %SED was associated with better performance at all four tests of executive attention and four out of seven tests of memory. These findings suggest that aerobic fitness, %MVPA and %SED are partly independent correlates of cognitive performance. To fully understand the association between SED and performance at several tests of cognitive function, future investigations might attempt to investigate intellectually engaging SED (such as reading books) separately from mentally undemanding SED (such as watching TV).

CognitiveConstruct

ExecutiveAttention

10.1080/09297049.2019.1702635

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

Child Neuropsychol

A child-focused version of the Attention Network Task designed to investigate interactions between the attention networks, including the endogenous orienting network.

A new variation of the Attention Network Task (ANT) was designed to measure the functioning of and interactions between the alerting, exogenous and endogenous visual spatial orienting, and executive control systems in young school children. Previous research has produced mixed results regarding typical functioning of the attention networks in six-year-olds; no ANT has measured the functioning of the endogenous network. This Staged ANT tested the Alerting, Exogenous, and Endogenous orienting networks in separate conditions. Two hundred and forty-seven children (average age 6 years, 103 girls) completed the task. There was no clear benefit of the alerting cue until the spatial orienting cues were introduced into the task, suggesting task complexity was needed before alerting benefits were observed. The validity effect of the exogenous cue was very strong: in contrast, the validity effect of the endogenous cue was very weak. The flanker effect was very strong. A benefit of the alerting cue was shown during both the exogenous and endogenous conditions, while a cost of the alerting cue was shown during the invalid exogenous trials. Neither the alerting nor validity effects interacted with the flanker effect. These results suggest that the alerting cue primes the exogenous and endogenous systems for the upcoming cues. Once the complexity of the task increases with the addition of the flankers, the alerting effect attenuates. The alerting and the two orienting networks interact together but the executive attention network acts independently, in children aged 6 years.

CognitiveConstruct

ExecutiveAttention

10.1136/bmjopen-2019-032619

BMJ open

BMJ Open

Training attention in children with acquired brain injury: a study protocol of a randomised controlled trial of the TALI attention training programme.

Childhood inattention has been linked with poor academic outcomes, and increased lifetime social, occupational and psychiatric morbidity. Children with an acquired brain injury (ABI) are particularly susceptible to attention deficits and may benefit from interventions aimed at enhancing attention. The primary objective of this study is to evaluate the short-term efficacy of the TALI Train programme, compared with a placebo, on the outcome of attention in children with ABI. The study is a parallel, double-blind, randomised controlled trial. Participants will consist of 80 children with a diagnosis of ABI aged 4-9 years 11 months. Participants will be randomly allocated to either (1) TALI Train (intervention group), an adaptive game-based attention training programme, or (2) a non-adaptive placebo programme (control group). Both programmes are delivered on a touchscreen tablet, and children complete five 20 min sessions per week for a 5-week period at home. Assessment of selective, sustained and executive attention (primary outcomes), and behavioural attention, working memory, social skills and mathematics ability (secondary outcomes) will occur at baseline, post-training, and at 3-month and 6-month follow-up to assess immediate and long-term efficacy of TALI Train compared with placebo. Assessments will be completed at the Royal Children's Hospital in Melbourne, Australia. All assessments and analyses will be undertaken by researchers blinded to group membership. Latent growth curve modelling will be employed to examine primary and secondary outcomes. Ethics approval has been obtained from the Royal Children's Hospital Human Research Ethics Committee (HREC) (38132) and the Monash University HREC (17446). Results will be disseminated through peer-reviewed journals, conference presentations, media outlets, the internet and various community/stakeholder activities. ACTRN12619000511134.

CognitiveConstruct

ExecutiveAttention

10.1371/journal.pone.0223690

PloS one

PLoS One

Toddler skills predict moderate-to-late preterm born children's cognition and behaviour at 6 years of age.

To compare moderate-to-late preterm born (32-36 weeks' gestation) to full term born (≥37 weeks' gestation) children in cognitive and behavioural functioning at the age of 6 years and assess which toddler skills predict later cognitive and behavioural functioning. A prospective longitudinal study with a cohort of 88 moderate-to-late preterm and 83 full term born Dutch children, followed from 18 months to 6 years of age. Orienting, alerting and executive attention skills were assessed at 18 months (corrected for prematurity), and cognitive, motor and language skills (Bayley-III-NL) at 24 months (corrected for prematurity). At 6 years (corrected for prematurity), cognitive (indices of IQ; WPPSI-III-NL) and behavioural functioning (CBCL/6-18) were assessed. Group differences and potential predictors were examined with MANCOVAs and hierarchical regression analyses. At 6 years, moderate-to-late preterm born children performed poorer than full term born children on cognitive processing speed, and they showed more behavioural attention problems. Attention problems at 6 years were predicted by poorer orienting attention skills at 18 months, while lower performance IQ was predicted by poorer alerting attention skills at 18 months. Full Scale IQ and Verbal IQ at 6 years were predicted by language skills at 24 months. Moderate-to-late preterm and full term born children showed some differing correlational patterns in the associations between early skills and later functioning, although in further analyses predictors appeared the same for both groups. Moderate-to-late preterm born children show specific vulnerabilities at primary school-age, particularly in cognitive processing speed and behavioural attention problems. Cognitive and behavioural functioning at 6 years can be predicted by differentiated attention skills at 18 months and language skills at 24 months.

CognitiveConstruct

ExecutiveAttention

10.1016/j.neuropsychologia.2019.107242

Neuropsychologia

Neuropsychologia

Time course of the inhibitory tagging effect in ongoing emotional processing. A HD-tDCS study.

When a cueing procedure that usually triggers inhibition of return (IOR) effects is combined with tasks that tap semantic processing, or involve response-based conflict, an inhibitory tagging (IT) emerges that disrupts responses to stimuli at inhibited locations. IT seems to involve the executive prefrontal cortex, mainly the left dorsolateral prefrontal cortex (DLPFC), in cognitive conflict tasks. Contrary to other inhibitory effects, IT has been observed with rather short intervals, concretely when the stimulus onset asynchrony (SOA) between the prime presented at the cued location, and the subsequent target is 250 ms. Here we asked whether IT is also applied to ongoing emotional processing, and whether the left DLPFC plays a causal role in IT using HD-tDCS. In two experiments with an emotional conflict task, we observed reduced conflict effects, the signature of IT, when the prime word was presented at the cued location, and once again when the prime-target SOA was just 250 ms. Also, the IT effect was eliminated when cathodal stimulation was applied to the left DLPFC. These findings suggest that the IT effect involves areas of the executive attention network and cooperates with IOR to favor attentional allocation to novel unexplored objects/locations, irrespective of their emotional content.

CognitiveConstruct

ExecutiveAttention

10.1111/desc.12918

Developmental science

Dev Sci

Common mechanisms of executive attention underlie executive function and effortful control in children.

Executive Function (EF) and Effortful Control (EC) have traditionally been viewed as distinct constructs related to cognition and temperament during development. More recently, EF and EC have been implicated in top-down self-regulation - the goal-directed control of cognition, emotion, and behavior. We propose that executive attention, a limited-capacity attentional resource subserving goal-directed cognition and behavior, is the common cognitive mechanism underlying the self-regulatory capacities captured by EF and EC. We addressed three related questions: (a) Do behavioral ratings of EF and EC represent the same self-regulation construct? (b) Is this self-regulation construct explained by a common executive attention factor as measured by performance on cognitive tasks? and (c) Does the executive attention factor explain additional variance in attention deficit hyperactivity disorder (ADHD) problems to behavioral ratings of self-regulation? Measures of performance on complex span, general intelligence, and response inhibition tasks were obtained from 136 preadolescent children (M = 11 years, 10 months, SD = 8 months), along with self- and parent-reported EC, and parent-reported EF, and ADHD problems. Results from structural equation modeling demonstrated that behavioral ratings of EF and EC measured the same self-regulation construct. Cognitive tasks measured a common executive attention factor that significantly explained 30% of the variance in behavioral ratings of self-regulation. Executive attention failed to significantly explain additional variance in ADHD problems beyond that explained by behavioral ratings of self-regulation. These findings raise questions about the utility of task-based cognitive measures in research and clinical assessment of self-regulation and psychopathology in developmental samples.

CognitiveConstruct

ExecutiveAttention

10.1177/1550059419881529

Clinical EEG and neuroscience

Clin EEG Neurosci

Faulty Executive Attention and Memory Interactions in Schizophrenia: Prefrontal Gray Matter Volume and Neuropsychological Impairment.

We hypothesized that neuropsychological disturbance in schizophrenia (SZ) may reflect faulty interactions of executive attention and episodic memory, emanating, in part, from reduced prefrontal cortex (PFC) gray matter volume. Participants with SZ (n = 84) and age-matched (n = 77) controls completed both the Wisconsin Card Sorting Test (WCST) and the Wechsler Memory Scale-Third Edition (WMS-III), used, respectively, as measures of executive attention and episodic memory. A subset of SZ (n = 27) and control (n = 17) groups also had available 3-T magnetic resonance imaging (MRI) studies of the PFC. For SZ, but not control groups, neuropsychological results indicated that executive attention interacted significantly with episodic memory, with failures of executive attention, as reflected by increased WCST perseverative errors, directly linked to poor performance on the WMS-III measure of delayed visual recall of action scenes. MRI results indicated reduced left PFC gray matter volume for SZ group, which in turn correlated significantly with their deficits in visual memory but not in executive attention. Results showed that 61% of the variance in neuropsychological performance in the SZ group was attributed to gray matter volume of left inferior prefrontal gyrus gray matter volume. PFC-mediated failure of executive attention-episodic memory interactions may represent an important mechanism in neuropsychological disturbance in SZ.

CognitiveConstruct

ExecutiveAttention

10.1016/B978-0-12-804281-6.00001-X

Handbook of clinical neurology

Handb Clin Neurol

The prefrontal cortex in the neurology clinic.

Throughout the nervous system, posterior structures are mainly devoted to receptive functions-sensation and perception-while anterior structures are devoted to motor functions. In the cortex, that dichotomy is unclear because perception and action are intertwined in the perception-action cycle, the biocybernetic cycle that adapts the organism to its environment. All neural systems store information (memory), which they enact in behavior and language. There are no "systems of memory" but the memory of systems. The cortex of the frontal lobe is a hierarchical system: motor cortex at the bottom for coordination of simple movements, and prefrontal cortex at the top for complex goal-directed actions. In the coordination of such actions, the frontal hierarchy engages the posterior (perceptual) cortex in the perception-action cycle. Inputs to the cycle come to prefrontal cortex from sensory-evoked perceptual memory and biologic (phyletic) memory. The first comes from neocortex, the second from limbic structures-through orbitomedial cortex. Outputs flow to pyramidal and diencephalic structures. Feedback inputs for monitoring and correction operate at all levels of the cycle. All prefrontal functions-planning, executive attention, working memory, decision-making, and inhibitory controls-are prospective, i.e., have a future perspective for the cycle to reach its goal. Damage to lateral prefrontal cortex impairs all of them. Orbitofrontal damage impairs the exclusionary aspect of attention and often leads to poor impulse control, excessive risk taking, unstable mood, and antisocial behavior. Medial prefrontal damage leads to poor monitoring of behavioral outcome for prevention of errors.

CognitiveConstruct

ExecutiveAttention

10.1093/geronb/gbz119

The journals of gerontology. Series B, Psychological sciences and social sciences

J Gerontol B Psychol Sci Soc Sci

Dual-Task Gait Assessment in a Clinical Sample: Implications for Improved Detection of Mild Cognitive Impairment.

Research has longitudinally linked dual-task gait dysfunction to mild cognitive impairment (MCI) and dementia risk. Our group previously demonstrated that dual-task gait speed assessment distinguished between subjective cognitive complaints (SCC) and MCI in a memory clinic setting, and also found that differences in dual-task gait speed were largely attributable to executive attention processes. This study aimed to reproduce these findings in a larger diverse sample and to extend them by examining whether there were group differences in single- versus dual-task cognitive performance (number of letters correctly sequenced backward). Two-hundred fifty-two patients (M age = 66.01 years, SD = 10.46; 119 MCI, 133 SCC) presenting with cognitive complaints in an academic medical setting underwent comprehensive neuropsychological and gait assessment (single- and dual-task conditions). Patients with MCI walked slower and showed greater decrement in cognitive performance than those with SCC during dual-task conditions. Neuropsychological measures of executive attention accounted for significant variance in dual-task gait performance across diagnostic groups beyond demographic and health risk factors. Reproduction of our results within a sample over four times the previous size provides support for the use of dual-task gait assessment as a marker of MCI risk in clinical settings.

CognitiveConstruct

ExecutiveAttention

10.1016/j.neuropsychologia.2019.107151

Neuropsychologia

Neuropsychologia

BLAST: A short computerized test to measure the ability to stay on task. Normative behavioral data and detailed cortical dynamics.

This article provides an exhaustive description of a new short computerized test to assess on a second-to-second basis the ability of individuals to « stay on task », that is, to apply selectively and repeatedly task-relevant cognitive processes. The task (Bron/Lyon Attention Stability Test, or BLAST) lasts around 1 min, and measures repeatedly the time to find a target letter in a two-by-two letter array, with an update of all letters every new trial across thirty trials. Several innovative psychometric measures of attention stability are proposed based on the instantaneous fluctuations of reaction times throughout the task, and normative data stratified over a wide range of age are provided by a large (>6000) dataset of participants aged 8 to 70. We also detail the large-scale brain dynamics supporting the task from an in-depth study of 32 participants with direct electrophysiological cortical recordings (intracranial EEG) to prove that BLAST involves critically large-scale executive attention networks, with a marked activation of the dorsal attention network and a deactivation of the default-mode network. Accordingly, we show that BLAST performance correlates with scores established by ADHD-questionnaires.

CognitiveConstruct

ExecutiveAttention

10.1016/j.physbeh.2019.112657

Physiology & behavior

Physiol Behav

A psychophysiological investigation of the interplay between orienting and executive control during stimulus conflict: A heart rate variability study.

It has been hypothesized that resting state cardiac vagal activity (CVA) - an indicator of parasympathetic nervous system activity - is a specific psychophysiological marker of executive control function. Here, we propose an alternative hypothesis - that CVA is associated with early stage attention orientation, promoting the flexible uptake of new information, on which the later operation of such executive control functions depends. We therefore predicted that CVA would predict the interaction between orienting and executive control. This was tested using the revised version of the Attention Network Test (ANT-R) that was developed to distinguish between orienting and executive attention during a stimulus conflict task. Healthy adults (N = 48) performed the ANT-R and their resting CVA was measured over a 5 min period using ECG recordings. Multiple regression analyses indicated that, when other factors were controlled for, CVA was more strongly associated with the interaction between the orienting and executive control terms than with either factor individually. Higher levels of CVA are specifically implicated in the modulation of executive control by intrinsic orientation operating at early stages of conflict detection. These initial findings of higher CVA on orienting attention in conflict detection need to be replicated in larger samples.

CognitiveConstruct

ExecutiveAttention

10.1080/09297049.2019.1639652

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

Child Neuropsychol

Neurocognitive processes underlying academic difficulties in very preterm born adolescents.

Very preterm birth is associated with academic difficulties, but the underlying neurocognitive mechanisms of these difficulties remain largely unclear. The present study aimed to assess the role of working memory (WM), attentional processes, and processing speed in academic difficulties of very preterm born adolescents at 13 years. Participants included 55 very preterm and 61 full-term adolescents. Academic performance, visuospatial WM, alerting, orienting, executive attention, sustained attention, and processing speed (simple and choice reaction time [RT]) were compared between groups. Mediation analyses with multiple, parallel mediators were performed to examine whether these functions mediate the relation between very preterm birth and academic performance. Very preterm born adolescents showed poorer reading comprehension, arithmetic, visuospatial WM, alerting, sustained attention, and choice RT than full-term controls. The relationship between very preterm birth and arithmetic was mediated by visuospatial WM, sustained attention, and choice RT. The relationship between very preterm birth and reading comprehension was mediated by visuospatial WM and choice RT. The findings indicate that very preterm birth affects arithmetic and reading comprehension through its negative effect on visuospatial WM, sustained attention, and processing speed. These neurocognitive processes may identify very preterm born children at risk for academic difficulties and could serve as targets for interventions.

CognitiveConstruct

ExecutiveAttention

10.1016/j.jagp.2019.05.017

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Am J Geriatr Psychiatry

The Construction and Evaluation of Executive Attention Training to Improve Selective Attention, Focused Attention, and Divided Attention for Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial.

To examine the immediate and long-term effects of executive attention training on selective attention, focused attention, and divided attention in older adults with mild cognitive impairment. A double-blind, multisite randomized controlled trial at five sites. Seventy participants (mean age: 78.19 ± 7.22 years) were assigned to an experimental group (executive attention training, n = 35) or an active control group (n = 35). The training duration was the same for both groups (45 minutes per session, 3 times per week, 18 sessions in total). Primary outcome measure was selective attention (Digit Span Task). Secondary outcome measures included focused attention (Stroop Color Word Test) and divided attention (Trail-Making Test Part B). Data were collected at pretest, post-test, 3-month follow-up, and 6-month follow-up. In GEE analysis, findings indicated a significant improvement in selective attention at post-test, whereas divided attention showed significant reducing omission error at 3-month follow-up. There was no significant effect of group in focused attention associated with the executive attention training compared with active control group. The executive attention training significantly improved selective attention and divided attention performance. Future studies should identify transfer effects of attention training, and that can employ early screening to provide integrated attention training, and decrease its relevant risks on competency in performing daily activities, such as falling and driving.

CognitiveConstruct

ExecutiveAttention

10.1038/s41598-019-45674-2

Scientific reports

Sci Rep

Discovery of Biomarker Panels for Neural Dysfunction in Inborn Errors of Amino Acid Metabolism.

Patients with inborn errors of amino acid metabolism frequently show neuropsychiatric symptoms despite accurate metabolic control. This study aimed to gain insight into the underlying mechanisms of neural dysfunction. Here we analyzed the expression of brain-derived neurotrophic factor (BDNF) and 10 genes required for correct brain functioning in plasma and blood of patients with Urea Cycle Disorders (UCD), Maple Syrup Urine Disease (MSUD) and controls. Receiver-operating characteristic (ROC) analysis was used to evaluate sensitivity and specificity of potential biomarkers. CACNA2D2 (α2δ2 subunit of voltage-gated calcium channels) and MECP2 (methyl-CpG binding protein 2) mRNA and protein showed an excellent neural function biomarker signature (AUC ≥ 0,925) for recognition of MSUD. THBS3 (thrombospondin 3) mRNA and AABA gave a very good biomarker signature (AUC 0,911) for executive-attention deficits. THBS3, LIN28A mRNA, and alanine showed a perfect biomarker signature (AUC 1) for behavioral and mood disorders. Finally, a panel of BDNF protein and at least two large neural AAs showed a perfect biomarker signature (AUC 1) for recognition of psychomotor delay, pointing to excessive protein restriction as central causative of psychomotor delay. To conclude, our study has identified promising biomarker panels for neural function evaluation, providing a base for future studies with larger samples.

CognitiveConstruct

ExecutiveAttention

10.1080/13825585.2019.1626799

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn

Age-related changes in time production and reproduction tasks: Involvement of attention and working memory processes.

Several studies have reported age-related differences in time estimation, which have been attributed either to a slowing of the pacemaker rate with aging or to impaired attention and/or working resources in older adults. Here, we compared performance of young and older participants on time production/reproduction tasks and on working memory, divided attention, sustained attention and executive attention tasks. Results showed that relative to young participants, older adults significantly under-reproduced and tended to over-produce target durations. Neither attention nor working memory predicted time reproduction and production performance. Conversely, when temporal variability was considered, participants' temporal variability in time production tasks was exclusively accounted for by age, whereas variability in temporal reproduction was also explained by divided attention and working memory. Overall, our results extend previous investigations on timing abilities in the elderly and underscore the importance of divided attention and working memory in the maintenance of a stable representation of durations.

CognitiveConstruct

ExecutiveAttention

10.1044/2019_JSLHR-L-18-0275

Journal of speech, language, and hearing research : JSLHR

J Speech Lang Hear Res

Effects of Signs on Word Learning by Children With Developmental Language Disorder.

Purpose This study investigated the effects of signs on word learning by children with developmental language disorder (DLD), in comparison with typically developing (TD) children, and the relation between a possible sign effect and children's linguistic and cognitive abilities. Method Nine- to 11-year-old children with DLD ( n = 40) and TD children ( n = 26) participated in a word learning experiment. Half of the spoken pseudowords were taught with a pseudosign with learning outcomes being assessed in accuracy and speed. To investigate whether sign effects would hold for children with varying linguistic and cognitive abilities, we measured children's linguistic (vocabulary, syntax) and cognitive (divided attention, working memory [WM], lexical access) skills. Results The children with DLD showed a positive sign effect in both accuracy and speed. For the TD children, there was no effect of signs on word learning. Principal component analyses of the linguistic and cognitive measures evidenced a 4-component solution (language skills, visual WM, verbal WM, and executive attention). Repeated-measures analyses of covariance with the component scores as covariates yielded no significant interactions with the linguistic and cognitive components. Conclusions Our results suggest that children with DLD benefit from signs for word learning, regardless of their linguistic and cognitive abilities. This implies that using sign-supported speech as a means to improve the vocabulary skills of children with DLD is effective, even still at the age of 9-11 years.

CognitiveConstruct

ExecutiveAttention

10.3389/fpsyg.2019.00845

Frontiers in psychology

Front Psychol

The Childhood Maltreatment Modulates the Impact of Negative Emotional Stimuli on Conflict Resolution.

It has been reported that negative emotional stimuli could facilitate conflict resolution. However, it remains unclear about whether and how the impact of negative emotional stimuli on conflict resolution varies depending on childhood maltreatment. To clarify this issue, seventy-nine subjects were required to perform an arrow Eriksen Flanker Task which was presented in the center of emotional pictures. The present study found a significant interaction effect of childhood maltreatment and emotion on executive attention scores in reaction times (RTs) that reflect conflict resolution speed. For subjects in high childhood maltreatment, negative pictures elicited smaller executive attention scores in RTs than neutral and positive pictures, while neutral and positive pictures elicited similar executive attention scores in RTs. By contrast, for subjects in low childhood maltreatment, executive attention scores in RTs were similar across three conditions. These results suggest that the speed of conflict resolution is enhanced in high, instead of low, childhood maltreatment in situations of negative stimuli. This finding extends our understanding of the interaction among emotion, childhood maltreatment and conflict resolution.

CognitiveConstruct

ExecutiveAttention

10.1007/s00406-019-00993-3

European archives of psychiatry and clinical neuroscience

Eur Arch Psychiatry Clin Neurosci

Attention as neurocognitive endophenotype of ADHD across the life span: a family study.

Endophenotypes mediate pathways between genetic variations and the psychiatric phenotype, or share genetic risk with the psychiatric phenotype. Identifying endophenotypes is an important step to unravel disease pathways underlying complex psychiatric phenotypes such as ADHD. Potential viable endophenotypes for ADHD across the lifespan are neurocognitive measures of basic attention functions, such as sustained attention, and executive attention functions (EF), such as inhibition. The present study evaluated the endophenotype criteria of familiality and state-independency for measures of basic attention and EF in affected- and unaffected parents of children with ADHD (N = 139), and typically developing children (N = 60). In addition, the added value of neurocognitive measures relative to questionnaire data in genetically informed designs was explored by comparing the intergenerational transmission of neurocognitive measures to those of ADHD symptom scores. Results revealed small-to-medium-sized familial effects of ADHD for reaction time measures of EF components and state-independency given familial effects. Parent-child correlations as estimates of intergenerational transmission of those neurocognitive measures were not higher than those of behavioral ADHD symptom ratings. Taken together, our results argue against neurocognitive measures as pivotal endophenotypes for ADHD across the lifespan. If studied as neurocognitive endophenotypes of ADHD in adults, reaction time measures of executive-rather than basic attention function-seem to be more sensitive.

CognitiveConstruct

ExecutiveAttention

10.1016/j.yebeh.2019.02.019

Epilepsy & behavior : E&B

Epilepsy Behav

Executive functioning in children with epilepsy: Genes matter.

Pediatric epilepsy has emerged as a chronic medical disease with a characteristic behavioral and cognitive phenotype, which includes compromised executive functioning (EF) and attention-related deficits. However, considerable interindividual variability exists; children often display very different or even opposite outcomes, and some children are more likely than others to develop neurocognitive problems in the face of similar individual and disease-related problems. The factors responsible for this interindividual variability are still largely unknown, but we do know that some genetic factors render the developing brain more susceptible to damage or traumatic experiences than others. Dopamine availability has a neuromodulatory function in the prefrontal cortex (PFC) and especially affects EF. Dopamine availability relates to polymorphisms in the gene encoding catechol-O-methyltransferase (COMT Val158Met), which in turn is affected by the methylation state of its promoter. Allelic variation of the methylenetetrahydrofolate reductase (MTHFR C677T) gene, alters methylation and may influence the methylation state of the COMT promoter. Given this, we tested the hypothesis that these polymorphisms interact in children with epilepsy, and that variability in allelic expression is associated with variability in cognitive phenotype. Executive function was tested directly and indirectly (parent-rated) in 42 children between 5 and 12 years of age. The MTHFR T allele carriers performed worse than MTHFR homozygous CC carriers on indirect EF, and a significant decline was observed when T allele carriers had at least one met allele of the COMT gene, especially on Working Memory. Direct EF was significantly compromised in COMT Val/Val carriers where reduced dopamine availability seems to confer a higher risk in a test that requests a high degree of executive attention and planning. This finding suggests that in children with epilepsy, genes that influence methylation and dopamine availability affect PFC-related EF. Therefore, we should consider genetic vulnerability as a polygenic risk, which might predispose for a particular phenotype and include specific genetic signatures as part of each patient's behavioral and cognitive profile from the moment that we start to take care of the child.

CognitiveConstruct

ExecutiveAttention

10.3390/bs9040043

Behavioral sciences (Basel, Switzerland)

Behav Sci (Basel)

Attention Network in Interpreters: The Role of Training and Experience.

The purpose of this study is to explore the relationship found between interpreting training and experience and the attentional network components: Alerting, orienting, and executive attention using the Attention Network Test (ANT). In the current study we tested three groups of interpreting students, translation students, and professional interpreters as specific forms of multilingual expertise. The student groups were tested longitudinally at the beginning and the end of their Master's programme. The professional interpreters were tested only one point in time. The results showed different attention network dynamics for the interpreting students compared to the translation students regarding alertness and executive network. First, the interpreting students showed a higher conflict effect when the alert cue was presented as well as a reduced accuracy compared to translation students. Second, the interpreting training had less effect on alerting than the translation training. Finally, two student groups showed a faster response time in conflict effect than the professional interpreters. In contrast, the professional interpreters scored a higher accuracy than two-student groups specifically in an incongruent alert condition, which confirms that they used a different responding strategy.

CognitiveConstruct

ExecutiveAttention

The Yale journal of biology and medicine

Yale J Biol Med

A Review on the Trajectory of Attentional Mechanisms in Aging and the Alzheimer's Disease Continuum through the Attention Network Test.

Multiple domains of cognition are known to decline in both normal aging and in the trajectory towards Alzheimer's disease (AD). While declines in episodic memory are most well-known in both normal aging and AD, some of these memory differences might stem from early deteriorations in attention that have consequences for later memory. Further complicating the matter is that attention is a multifaceted construct that might be differentially affected in normal aging and AD. According to cognitive neuroscience models of attention, three types of attention networks exist: alerting, orienting, and executive. Efficiency of these three networks can be captured using the Attention Network Test (ANT). We reviewed the literature investigating differences in attention networks using the ANT as a function of normal aging and the AD trajectory, which included people at risk for AD, preclinical stages of AD, mild cognitive impairment, and those diagnosed with AD. We found that normal aging and the AD trajectory evidenced different patterns of attentional declines. Whereas normal aging was most consistently associated with impairments in alerting, early phases of the AD trajectory were most consistently associated with impairments in executive attention, and later phases of the AD trajectory were mixed. The mixed results with AD are largely attributed to small sample sizes and confounding effects of general slowing. These findings highlight key gaps in the literature linking different phases of AD while also highlighting the usefulness of the ANT to distinguish normal aging from the AD trajectory, especially in the earliest phases of the disease process.

CognitiveConstruct

ExecutiveAttention

10.1016/j.bbr.2019.03.028

Behavioural brain research

Behav Brain Res

Enhanced executive attention efficiency after adaptive force control training: Behavioural and physiological results.

Attention plays an important role in perception and cognition, and developing an effective method to train and improve attention is an essential and challenging task. In this study, fingertip-based adaptive force control tasks (AFCT) were explored for attention training, and the visual-channel task called an attention network test (ANT) was used to measure the level of attention before and after AFCT. The purposes of this study were to investigate whether AFCT can enhance the attention level on the ANT task and to elucidate the underlying electrophysiological mechanisms. The results showed that the efficiency of the executive control network during ANT was significantly improved by the AFCT training, indicating that the AFCT training may enhance the executive attention level during visual-channel tasks. To measure the behavioural performance during the AFCT training, we used tolerance, variance and duration of the forces to design a comprehensive score of behavioural performance (CSBP), and the electrophysiological mechanisms were also explored using electroencephalography (EEG) recordings. The AFCT and ANT results showed consistency in medial frontal theta activity and in connectivity strength at frontal-parietal regions in the alpha band. These results indicated that the observed attention improvement across tasks executed using different sensory channels may be due to the training of overlapping components of the relevant attention networks. Thus, this study provides further insight into the design of training tasks that stimulate multi-sensory channels, which can be used to improve attention and treat various attention deficit disorders.

CognitiveConstruct

ExecutiveAttention

10.1016/j.bandc.2019.03.001

Brain and cognition

Brain Cogn

Should we pay attention to eye movements? The impact of bilateral eye movements on behavioral and neural responses during the Attention Network Test.

Bilateral eye movements (EMs) have been associated with enhancements in episodic memory and creativity. We explored the influence of EMs on behavior and event related potential (ERP) responses during the Attention Network Test (ANT). Participants completed ANT trials after bilateral EMs or a center-fixation control manipulation. We examined condition (EM, control) and handedness (consistent, inconsistent) differences for overall task performance, as well as alerting, orienting, and executive attention networks. Behaviorally, there was a trend for inconsistent-handed participants to display faster RTs across cue types, and greater accuracy for no cue, double, and center cue trials when compared to consistent handers, yet consistent handers garnered greater improvements in behavior following altering and orienting cues than inconsistent handers. Although there were no behavioral differences between EM and control conditions, target-locked N100 and P200 ERPs were weaker in the EM than control condition for all cue types, except spatial cues for which there were no differences between groups. Because stronger N100 and P200 responses have been linked to increased selective attention, we speculate that ERP differences between EM and control conditions, in the absence of behavioral differences, may indicate that participants exposed to EMs required less selective attention to successfully complete the task.

CognitiveConstruct

ExecutiveAttention

10.1007/s10461-019-02423-w

AIDS and behavior

AIDS Behav

Impaired Neurocognitive Performance and Mortality in HIV: Assessing the Prognostic Value of the HIV-Dementia Scale.

This study examined whether global HIV-associated neurocognitive impairment (NCI), assessed with the HIV-Dementia Scale (HDS), predicted mortality in an ethnically diverse sample of 209 HIV-positive adults. Participants were predominantly in the mid-range of illness at baseline, and followed over 13-years. At baseline, 31 (15%) participants scored in the NCI range (HDS ≤ 10); 58 (28%) died during follow-up. Baseline NCI was significantly associated with earlier mortality (HR = 2.10, 95% CI [1.10-4.00]) independent of sociodemographic and HIV disease-related covariates. Less errors on the antisaccade task, an index of executive/attention control, was the only HDS subtest predicting earlier mortality (HR = 0.72, 95% CI [0.58-0.90]). In the absence of an AIDS-defining condition, NCI, particularly in the executive/attention domain, is an independent prognostic marker of mortality in a diverse HIV-positive cohort. These findings highlight the clinical utility of brief cognitive screening measures in this population.

CognitiveConstruct

ExecutiveAttention

10.3389/fpsyg.2019.00042

Frontiers in psychology

Front Psychol

Cognitive Restoration in Children Following Exposure to Nature: Evidence From the Attention Network Task and Mobile Eye Tracking.

Exposure to nature improves cognitive performance through a process of cognitive restoration. However, few studies have explored the effect in children, and no studies have explored how eye movements "in the wild" with mobile eye tracking technology contribute to the restoration process. Our results demonstrated that just a 30-min walk in a natural environment was sufficient to produce a faster and more stable pattern of responding on the Attention Network Task, compared with an urban environment. Exposure to the natural environment did not improve executive (directed) attention performance. This pattern of results supports suggestions that children and adults experience unique cognitive benefits from nature. Further, we provide the first evidence of a link between cognitive restoration and the allocation of eye gaze. Participants wearing a mobile eye-tracker exhibited higher fixation rates while walking in the natural environment compared to the urban environment. The data go some way in uncovering the mechanisms sub-serving the restoration effect in children and elaborate how nature may counteract the effects of mental fatigue.

CognitiveConstruct

ExecutiveAttention

10.2147/JPR.S184183

Journal of pain research

J Pain Res

Does experimentally induced pain affect attention? A meta-analytical review.

Recent studies have found that clinical pain is related to cognitive impairment. However, there remains a scarcity of systematic reviews on the influence of acute pain on attention. Laboratory-induced pain is often used to simulate acute pain. The current systematic meta-analysis aimed to evaluate the effect of induced-pain on three components of attention (orienting, alerting, and executive attention) in healthy subjects. A systematic search of three databases was performed. Only data from studies that administered laboratory-induced pain and that also included a control group were selected. The effects of experimental pain on orienting attention, alerting attention, and executive attention were analyzed. Two reviewers assessed the studies and extracted relevant data according to the Cochrane Collaboration and Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. Eight studies were included in the meta-analysis. Orienting attention was marginally interrupted by pain under the invalid cue and marginally facilitated by pain under the valid cue condition. Performance on alerting attention was decreased by pain. Executive attention was not significantly affected by pain. There was moderate evidence that experimentally induced pain can produce effects on orienting and alerting attention but not on executive attention. This meta-analysis suggests that experimentally induced pain influences some aspects of attention.

CognitiveConstruct

ExecutiveAttention

10.4103/ijoy.IJOY_26_17

International journal of yoga

Int J Yoga

Association between Cyclic Meditation and Creative Cognition: Optimizing Connectivity between the Frontal and Parietal Lobes.

Important stages of creativity include preparation, incubation, illumination, and verification. Earlier studies have reported that some techniques of meditation promote creativity but have not specified which stage is enhanced. Here, we report the influence of cyclic meditation (CM) on creative cognition measured by a divergent thinking task. Our aim was to determine the degree of association between the two. Twenty-four university students were randomly assigned to an experimental group (CM) and controls (Supine Rest), 35 min/day for 7 days. Creativity performance was assessed pre and post using Abbreviated Torrance Test for Adults (ATTA), while 64-channel electroencephalography (EEG) was used to measure brain activity during both CM/SH and the creativity test. Results indicated that CM training improved creativity performance, producing a shift to predominant gamma activity during creativity compared controls who showed delta activity. Furthermore, the experimental group showed more activation of frontal and parietal regions (EEG leads F3, F4 and P3, P4) than controls, i.e., the regions of the executive network responsible for creative cognition, our particular regions of interest where specialized knowledge is being stored. Improvement on creativity test performance indicates that CM increases association and strengthens the connectivity between frontal and parietal lobes, the major nodes of default mode network and executive attention network, enhancing the important stages of creativity such as preparation, incubation, and illumination.

CognitiveConstruct

ExecutiveAttention

10.1177/0018720818822350

Human factors

Hum Factors

The Abbreviated Vigilance Task and Its Attentional Contributors.

To measure contributing attentional processes, particularly that of executive attention, to two iterations of the abbreviated vigilance task. Joel Warm was at the forefront of vigilance research for decades, and resource theory is currently the dominant explanation for the vigilance decrement. The underlying mechanisms contributing to both overall performance and the decrement are only partly understood. Seventy-eight participants answered questionnaires about their attentional skills and stress state, performed the Attention Network Test and two blocks of the 12-min abbreviated vigilance task, with a brief break between the two vigils during which they viewed images intended to affect performance. Changes in oxygenated hemoglobin were measured with functional near-infrared imaging. Expected patterns were observed for both iterations of the abbreviated vigilance task, with performance declining after the first 2 min. Manipulations intended to evaluate whether executive processes contributed to vigilance performance failed to observe an effect. Other factors, particularly orienting and alerting attentional networks, task engagement, and subclinical ADHD symptomology were associated with performance. Significant factors for the first and second vigilance blocks were different. We suggest that (a) cognitive control is not a predominant factor, at least for the abbreviated vigilance task, and (b) attentional mechanisms and stress states affecting performance on the abbreviated vigilance task change over time. Potential applications of this research include the use of breaks for sustained attention tasks involving high sensory load, and implications for the use of the abbreviated vigilance task as a proxy for general vigilance processes.

CognitiveConstruct

ExecutiveAttention

10.1007/s00221-018-05466-y

Experimental brain research

Exp Brain Res

The impact of cognitive load on processing efficiency and performance effectiveness in anxiety: evidence from event-related potentials and pupillary responses.

Anxiety has been associated with poor attentional control, as reflected in lowered performance on experimental measures of executive attention and inhibitory control. Recent conceptualisations of anxiety propose that individuals who report elevated anxiety symptoms worry about performance and will exert greater cognitive effort to complete tasks well, particularly when cognitive demands are high. Across two experiments, we examined the effect of anxiety on task performance and across two load conditions using (1) measures of inhibitory control (behavioural reaction times and eye-movement responses) and (2) task effort with pupillary and electrocortical markers of effort (CNV) and inhibitory control (N2). Experiment 1 used an oculomotor-delayed-response task that manipulated load by increasing delay duration to create a high load, relative to a low load, condition. Experiment 2 used a Go/No-Go task and load was manipulated by decreasing the No-Go probabilities (i.e., 20% No-Go in the high load condition and 50% No-Go in the low load condition). Experiment 1 showed individuals with high (vs. low) anxiety made more antisaccade errors across load conditions, and made more effort during the high load condition, as evidenced by greater frontal CNV and increased pupillary responses. In Experiment 2, individuals with high anxiety showed increased effort (irrespective of cognitive load), as characterised by larger pupillary responses. In addition, N2 amplitudes were sensitive to load only in individuals with low anxiety. Evidence of reduced performance effectiveness and efficiency across electrophysiological, pupillary, and oculomotor systems in anxiety provides some support for neurocognitive models of frontocortical attentional dysfunction in anxiety.

CognitiveConstruct

ExecutiveAttention

10.3389/fpsyt.2018.00709

Frontiers in psychiatry

Front Psychiatry

Staging, Neurocognition and Social Functioning in Bipolar Disorder.

Bipolar disorder (BD) is associated with significant neurocognitive and functional impairment, which may progress across stages. The 'latent stage' of BD remains understudied. This cross-sectional study assessed staging, neurocognition and social functioning among BD patients and their healthy siblings. Four groups were included: euthymic type I BD patients in the early ( = 25) and late ( = 23) stages, their healthy siblings (latent stage; = 23) and healthy controls ( = 21). All 92 subjects underwent a comprehensive neuropsychological battery of processing speed, verbal learning/memory, visual memory, working memory, verbal fluency, executive cognition, and motor speed. Social functioning was assessed using the FAST scale. Siblings' social functioning was identical to that of controls, and significantly better than both early- ( < 0.005) and late- ( < 0.001) stage patients. Although all patients were strictly euthymic, those at late stages had a significantly worse social functioning than early-stage patients ( < 0.001). Compared to controls, increasingly greater neurocognitive dysfunction was observed across stages of BD ( = 1.59; = 0.005). Healthy siblings' performance lied between those of controls and patients, with deficits in tasks of processing speed, executive attention, verbal memory/learning, and visual memory. Both early- and late-stage patients had a more severe and widespread dysfunction than siblings, with no significant differences between them. Genetic vulnerability to BD-I seems to be associated with neurocognitive impairments, whereas social dysfunction would be the result of the clinical phenotype. Staging models of BD should take into account these divergent findings in the latent stage.

CognitiveConstruct

ExecutiveAttention

10.1111/tops.12407

Topics in cognitive science

Top Cogn Sci

An Integrated Working Memory Model for Time-Based Resource-Sharing.

The time-based resource-sharing (TBRS) model envisions working memory as a rapidly switching, serial, attentional refreshing mechanism. Executive attention trades its time between rebuilding decaying memory traces and processing extraneous activity. To thoroughly investigate the implications of the TBRS theory, we integrated TBRS within the ACT-R cognitive architecture, which allowed us to test the TBRS model against both participant accuracy and response time data in a dual task environment. In the current work, we extend the model to include articulatory rehearsal, which has been argued in the literature to be a separate mechanism from attentional refreshing. Additionally, we use the model to predict performance under a larger range of cognitive load (CL) than typically administered to human subjects. Our simulations support the hypothesis that working memory capacity is a linear function of CL and suggest that this effect is less pronounced when articulatory rehearsal is available.

CognitiveConstruct

ExecutiveAttention

10.1093/cercor/bhy332

Cerebral cortex (New York, N.Y. : 1991)

Cereb Cortex

Connectivity of Frontoparietal Regions Reveals Executive Attention and Consciousness Interactions.

The executive control network is involved in the voluntary control of novel and complex situations. Solving conflict situations or detecting errors have demonstrated to impair conscious perception of near-threshold stimuli. The aim of this study was to explore the neural mechanisms underlying executive control and its interaction with conscious perception using functional magnetic resonance imaging and diffusion-weighted imaging. To this end, we used a dual-task paradigm involving Stroop and conscious detection tasks with near-threshold stimuli. A set of prefrontal and frontoparietal regions were more strongly engaged for incongruent than congruent trials while a distributed set of frontoparietal regions showed stronger activation for consciously than nonconsciously perceived trials. Functional connectivity analysis revealed an interaction between executive control and conscious perception in frontal and parietal nodes. The microstructural properties of the middle branch of the superior longitudinal fasciculus were associated with neural measures of the interaction between executive control and consciousness. These results demonstrate that conscious perception and executive control share neural resources in frontoparietal networks, as proposed by some influential models.

CognitiveConstruct

ExecutiveAttention

10.3389/fnhum.2018.00491

Frontiers in human neuroscience

Front Hum Neurosci

Cognitive Control Over Visual Motion Processing - Are Children With ADHD Especially Compromised? A Pilot Study of Flanker Task Event-Related Potentials.

Performance deficits and diminished brain activity during cognitive control and error processing are frequently reported in attention deficit/hyperactivity disorder (ADHD), indicating a "top-down" deficit in executive attention. So far, these findings are almost exclusively based on the processing of static visual forms, neglecting the importance of visual motion processing in everyday life as well as important attentional and neuroanatomical differences between processing static forms and visual motion. For the current study, we contrasted performance and electrophysiological parameters associated with cognitive control from two Flanker-Tasks using static stimuli and moving random dot patterns. Behavioral data and event-related potentials were recorded from 16 boys with ADHD (combined type) and 26 controls (aged 8-15 years). The ADHD group showed less accuracy especially for moving stimuli, and prolonged response times for both stimulus types. Analyses of electrophysiological parameters of cognitive control revealed trends for diminished N2-enhancements and smaller error-negativities (indicating medium effect sizes), and we detected significantly lower error positivities (large effect sizes) compared to controls, similarly for both static and moving stimuli. Taken together, the study supports evidence that motion processing is not fully developed in childhood and that the cognitive control deficit in ADHD is of higher order and independent of stimulus type.

CognitiveConstruct

ExecutiveAttention

10.1093/scan/nsy113

Social cognitive and affective neuroscience

Soc Cogn Affect Neurosci

Clarifying the relationship between mindfulness and executive attention: a combined behavioral and neurophysiological study.

Mindfulness is frequently associated with improved attention. However, the nature of the relationship between mindfulness and executive attention, a core function of the attentional system, is surprisingly unclear. Studies employing behavioral measures of executive attention have been equivocal. Although neuroscientific studies have yielded more consistent findings, reporting functional and structural changes in executive attention brain regions, the observed changes in brain activity have not been linked to behavioral performance. The current study aimed to fill these gaps in the literature by examining the extent to which trait mindfulness related to behavioral and neurophysiological (indexed by the stimulus-locked P3) measures of executive attention. Results revealed that higher trait mindfulness was related to less flanker interference on accuracy and reaction time, consistent with enhanced executive attention. Critically, mediational analyses showed that the P3 accounted for the relationship between trait mindfulness and executive attention performance, elucidating a neural mechanism through which mindfulness enhances executive attention.

CognitiveConstruct

ExecutiveAttention

10.1037/neu0000507

Neuropsychology

Neuropsychology

The influence of aerobic fitness on top-down and bottom-up mechanisms of interference control.

Extensive evidence has demonstrated the relationship between aerobic fitness and cognitive function in early adulthood. Little is known, however, about whether the cognitive benefits of aerobic fitness are related to the modulation of top-down or bottom-up mechanisms in the control of executive attention. The present study aimed to shed light on this question by evaluating the phase-locking factor (PLF) of electroencephalogram (EEG) signal during cognitive control. Higher fit and lower fit young adults performed a neuropsychological test of cognitive control (i.e., Stroop color-naming task) with concurrent EEG recording. In line with previous literature, behavioral results showed that higher fit individuals performed better on the Stroop task overall. Interestingly, beta phase synchronization was larger during the incongruent condition than the congruent condition for higher fit but not for lower fit individuals, suggesting a more effective use of top-down control in the former. However, no such effect was seen for gamma activity, indicating that bottom-up mechanisms are unlikely to account for the differences in performance explained by fitness levels. Altogether, these findings suggest that the greater cognitive control observed in higher fit individuals is associated with differences in the control of top-down rather than bottom-up processing, consistent with the hypothesis of selective improvement. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

CognitiveConstruct

ExecutiveAttention

10.1093/brain/awy264

Brain : a journal of neurology

Brain

Atrophy subtypes in prodromal Alzheimer's disease are associated with cognitive decline.

Alzheimer's disease is a heterogeneous disorder. Understanding the biological basis for this heterogeneity is key for developing personalized medicine. We identified atrophy subtypes in Alzheimer's disease dementia and tested whether these subtypes are already present in prodromal Alzheimer's disease and could explain interindividual differences in cognitive decline. First we retrospectively identified atrophy subtypes from structural MRI with a data-driven cluster analysis in three datasets of patients with Alzheimer's disease dementia: discovery data (dataset 1: n = 299, age = 67 ± 8, 50% female), and two independent external validation datasets (dataset 2: n = 181, age = 66 ± 7, 52% female; dataset 3: n = 227, age = 74 ± 8, 44% female). Subtypes were compared on clinical, cognitive and biological characteristics. Next, we classified prodromal Alzheimer's disease participants (n = 603, age = 72 ± 8, 43% female) according to the best matching subtype to their atrophy pattern, and we tested whether subtypes showed cognitive decline in specific domains. In all Alzheimer's disease dementia datasets we consistently identified four atrophy subtypes: (i) medial-temporal predominant atrophy with worst memory and language function, older age, lowest CSF tau levels and highest amount of vascular lesions; (ii) parieto-occipital atrophy with poor executive/attention and visuospatial functioning and high CSF tau; (iii) mild atrophy with best cognitive performance, young age, but highest CSF tau levels; and (iv) diffuse cortical atrophy with intermediate clinical, cognitive and biological features. Prodromal Alzheimer's disease participants classified into one of these subtypes showed similar subtype characteristics at baseline as Alzheimer's disease dementia subtypes. Compared across subtypes in prodromal Alzheimer's disease, the medial-temporal subtype showed fastest decline in memory and language over time; the parieto-occipital subtype declined fastest on executive/attention domain; the diffuse subtype in visuospatial functioning; and the mild subtype showed intermediate decline in all domains. Robust atrophy subtypes exist in Alzheimer's disease with distinct clinical and biological disease expression. Here we observe that these subtypes can already be detected in prodromal Alzheimer's disease, and that these may inform on expected trajectories of cognitive decline.

CognitiveConstruct

ExecutiveAttention

10.3389/fpsyt.2018.00435

Frontiers in psychiatry

Front Psychiatry

Analysis of Attention Subdomains in Obstructive Sleep Apnea Patients.

Obstructive sleep apnea (OSA) is characterized by apnea-hypopnea during sleep. Overnight polysomnography (PSG) is usually used to detect the frequency of apneic and hypopneic events. Attention and executive deficits are commonly reported in OSA patients. Previous investigations suggested that cognitive impairments were dependent on attention deficits. However, attention is not a unitary domain and consists of different subdomains such as alertness, sustained attention, focused attention, and executive attention (impulsivity/hyperactivity). Little is known about the attention subdomains affected in OSA. Attention is commonly assessed using continuous performance tests, such as the continuous visual attention test (CVAT). Distinct variables can be derived from the CVAT. Each CVAT variable is associated with a specific attention subdomain. This study aimed to examine the variables of the CVAT that are affected by OSA and to identify the most reliable CVAT variable that distinguishes OSA from controls via discriminant analysis. Patients scheduled to perform a PSG were invited to participate in this study. Immediately before the PSG, they performed the CVAT. Based on the PSG results, 27 treatment-naïve OSA patients were sampled. The same number of healthy controls were selected to match the two groups by age and gender. Five CVAT variables were examined: commission errors, omission errors, reaction time (RT), variability of reaction time (VRT), and coefficient of variability (VRT/RT). ANCOVAs indicated that RT and VRT were affected by OSA. No difference in accuracy (omission and commission errors) was observed between healthy controls and OSA patients. When the VRT measurements were corrected for their respective RT values (VRT/RT), the mean difference on this coefficient did not reach significance. The discriminant analysis indicated that the two groups could be best differentiated by the RT variable. Attention problems, commonly observed in OSA patients, may reflect a primary problem on the alertness subdomain. The CVAT was able to detect the primary (alertness-RT parameter) and the secondary deficits (sustained attention-VRT parameter) associated with OSA. As there is no learning effect in the condition of retests, the CVAT can be used to assess the cognitive recovery in OSA patients during treatment.

CognitiveConstruct

ExecutiveAttention

10.3758/s13428-018-1131-7

Behavior research methods

Behav Res Methods

Remote associates test: An empirical proof of concept.

Associative processes play a major role in research on human thinking, especially creativity. One of the most influential models emphasizing associative processes in creative thinking was introduced by Mednick (Psychological Review, 69, 220-232, 1962), who developed the remote associates test (RAT) as a domain-general measure of individual differences in associative hierarchies. Although S. Mednick's theoretical framework has recently regained much attention, the fundamental psychometric assumptions and underlying cognitive processes involved in the RAT remain controversial. We carried out two studies to evaluate these issues. In the first, a confirmatory factor analysis showed that a single latent factor accounted for the ability to solve RAT problems, despite their psycholinguistic heterogeneity. Subsequent regression analyses indicated that cue-solution associative remoteness substantially determined the difficulty of RAT problems, accounting for about 80% of variance. In the second study we used a newly developed associative chain test (ACT), which assesses lexical-semantic and executive measures during associative processing. We found that performance on the RAT was related to lexical-semantic (higher response remoteness and lower response commonness) but not to executive (response inhibition and switching) ACT measures. Overall, our findings indicate that the RAT reflects a coherent ability to access and combine remote elements in lexical-semantic and associative networks without considerably engaging executive attention. Although the validity and utility of the RAT was supported, we propose that the ACT provides a more complex and fine-grained tool for the assessment of associative processing.

CognitiveConstruct

ExecutiveAttention

10.1111/desc.12756

Developmental science

Dev Sci

Metacognitive scaffolding boosts cognitive and neural benefits following executive attention training in children.

Interventions including social scaffolding and metacognitive strategies have been used in educational settings to promote cognition. In addition, increasing evidence shows that computerized process-based training enhances cognitive skills. However, no prior studies have examined the effect of combining these two training strategies. The goal of this study was to test the combined effect of metacognitive scaffolding and computer-based training of executive attention in a sample of typically developing preschoolers at the cognitive and brain levels. Compared to children in the regular training protocol and an untrained active control group, children in the metacognitive group showed larger gains on intelligence and significant increases on an electrophysiological index associated with conflict processing. Moreover, changes in the conflict-related brain activity predicted gains in intelligence in the metacognitive scaffolding group. These results suggest that metacognitive scaffolding boosts the influence of process-based training on cognitive efficiency and brain plasticity related to executive attention.

CognitiveConstruct

ExecutiveAttention

10.1177/1087054718797428

Journal of attention disorders

J Atten Disord

Attention in Children With Autism Spectrum Disorder and the Effects of a Mindfulness-Based Program.

Children with autism spectrum disorder (ASD) show atypical attention. Mindfulness-based programs (MBPs), with self-regulation of attention as a basic component, could benefit these children. We investigated how 49 children with ASD differed from 51 typically developing (TD) children in their attention systems; and whether their attention systems were improved by an MBP for children and their parents (MYmind), using a cognitive measure of attention, the Attention Network Test. Children with ASD did not differ from TD children in the speed of the attention systems, but were somewhat less accurate in their orienting and executive attention. Also, MYmind did not significantly improve attention, although trend effects indicated improved orienting and executive attention. Robustness checks supported these improvements. Trend effects of the MBP on the attention systems of children with ASD were revealed, as well as minor differences between children with ASD and TD children in their attention systems.

CognitiveConstruct

ExecutiveAttention

10.1007/s10548-018-0676-1

Brain topography

Brain Topogr

Grey Matter Volumes in the Executive Attention System Predict Individual Differences in Effortful Control in Young Adults.

Effortful control (EC), considered as one component of temperament, describes an individual's capacity for self-regulation. Previous neuroimaging studies have provided convergent evidence that individual differences in EC are determined by the functioning of neural systems subserving executive attention, primarily comprising the anterior cingulate cortex (ACC) and the lateral prefrontal cortex (PFC). Notwithstanding, as previous neuroimaging findings highlighted the structural neural bases of EC in adolescence, during which the PFC is prominently remodeled, the underlying neuroanatomical substrates of EC remain uncertain in young adults. In this study, we included 246 healthy young adults and used voxel-based morphometry analysis to investigate the relationship between EC and grey matter (GM) volumes. Additionally, permutation testing and cross-validation were applied to determine whether GM volumes in the detected regions could predict individual differences in EC. Our results revealed that EC was associated with GM volumes in the dorsal anterior cingulate cortex (dACC) and the pre-supplementary motor area (pre-SMA), demonstrating that these two regions may play a crucial role in EC. Furthermore, the identified regional GM volumes reliably contribute to the prediction of EC confirmed by cross-validation. Overall, these findings provide further evidence for the involvement of the executive attention system in EC, and shed more light on the neuroanatomical substrates of EC in young adulthood.

CognitiveConstruct

ExecutiveAttention

10.3389/fnhum.2018.00315

Frontiers in human neuroscience

Front Hum Neurosci

Brief Mindfulness Meditation Improves Attention in Novices: Evidence From ERPs and Moderation by Neuroticism.

Past research has found that mindfulness meditation training improves executive attention. Event-related potentials (ERPs) have indicated that this effect could be driven by more efficient allocation of resources on demanding attentional tasks, such as the Flanker Task and the Attention Network Test (ANT). However, it is not clear whether these changes depend on long-term practice. In two studies, we sought to investigate the effects of a brief, 10-min meditation session on attention in novice meditators, compared to a control activity. We also tested moderation by individual differences in neuroticism and the possible underlying neural mechanisms driving these effects, using ERPs. In Study 1, participants randomly assigned to listen to a 10-min meditation tape had better accuracy on incongruent trials on a Flanker task, with no detriment in reaction times (RTs), indicating better allocation of resources. In Study 2, those assigned to listen to a meditation tape performed an ANT more quickly than control participants, with no detriment in performance. Neuroticism moderated both of these effects, and ERPs showed that those individuals lower in neuroticism who meditated for 10 min exhibited a larger N2 to incongruent trials compared to those who listened to a control tape; whereas those individuals higher in neuroticism did not. Together, our results support the hypothesis that even brief meditation improves allocation of attentional resources in some novices.

CognitiveConstruct

ExecutiveAttention

10.1186/s13195-018-0413-8

Alzheimer's research & therapy

Alzheimers Res Ther

Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer's disease.

Patients with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) show functional and structural connectivity alterations in the default mode network (DMN) while cerebrovascular disease (CeVD) shows functional and structural connectivity changes in the executive control network (ECN). Such disruptions are associated with memory and executive function impairment, respectively. Concurrent AD and CeVD pathology is associated with a higher rate of cognitive decline and differential neurodegenerative patterns. Together, such findings are likely reflective of different underlying pathology in AD with and without CeVD. However, few studies have examined the effect of CeVD on network functional connectivity (task-free functional magnetic resonance imaging (fMRI)) and structural connectivity (diffusion MRI) of the DMN and ECN in aMCI and AD using a hypothesis-driven multiple seed-based approach. We examined functional and structural connectivity network changes in 39 aMCI, 50 aMCI+CeVD, 47 AD, 47 AD+CeVD, and 65 healthy controls (HCs) and their associations with cognitive impairment in the executive/attention and memory domains. We demonstrate divergent DMN and ECN functional connectivity changes in CeVD and non-CeVD subjects. Compared with controls, intra-DMN hippocampal functional connectivity reductions were observed in both AD and AD+CeVD, while intra-DMN parietal and medial prefrontal-parietal functional connectivity was higher in AD+CeVD and aMCI+CeVD, but lower in AD. Intra-ECN frontal functional connectivity increases and fronto-parietal functional connectivity decreases occurred in CeVD but not non-CeVD subjects. Such functional connectivity alterations were related with cognitive impairment in a dissociative manner: intra-DMN functional connectivity changes were associated with worse cognition primarily in non-CeVD groups, while intra-ECN functional connectivity changes were associated with worse cognition primarily in CeVD groups. Additionally, CeVD and non-CeVD groups showed overlapping and distinct alterations in inter-network DMN-ECN functional connectivity depending on disease severity. In contrast to functional connectivity, CeVD groups had greater network structural connectivity damage compared with non-CeVD groups in both aMCI and AD patients. Network structural connectivity damage was associated with worse cognition. We demonstrate differential functional and structural network changes between aMCI and AD patients with and without CeVD through diverging and deleterious network-based degeneration underlying domain-specific cognitive impairment.

CognitiveConstruct

ExecutiveAttention

10.1080/16506073.2018.1506819

Cognitive behaviour therapy

Cogn Behav Ther

Executive attention moderates the effect of trait anxiety on hyperarousal symptoms.

The majority of individuals exposed to trauma do not go on to develop posttraumatic stress disorder (PTSD); thus, researchers have sought to identify individual difference variables that make one particularly susceptible to posttraumatic stress symptoms. Trait anxiety is one individual difference variable implicated in the pathogenesis of posttraumatic stress symptoms. Following from cognitive theories of anxiety and extant data, the purpose of the present study was to examine executive attention as a moderator of the relation between trait anxiety and posttraumatic stress symptoms, particularly hyperarousal symptoms, among undergraduate women reporting trauma exposure (= 88). As predicted, executive attention moderated the association between trait anxiety and hyperarousal symptoms, such that there was a significantly weaker relation as executive attention increased. Study results further support the potential buffering effect of executive attention in relation to posttraumatic stress symptoms, as well as the possible importance of targeting executive attention following trauma exposure.

CognitiveConstruct

ExecutiveAttention

10.1007/s00213-018-4968-7

Psychopharmacology

Psychopharmacology (Berl)

Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks.

Alcohol-associated stimuli capture attention, yet drinkers differ in the precise stimuli that become paired with intoxication. Extending our prior work to examine the influence of alcoholism risk factors, we paired abstract visual stimuli with intravenous alcohol delivered covertly and examined brain responses to these Pavlovian-conditioned stimuli in fMRI when subjects were not intoxicated. Sixty healthy drinkers performed task-irrelevant alcohol conditioning that presented geometric shapes as conditioned stimuli. Shapes were paired with a rapidly rising alcohol limb (conditioned stimulus; CS+) using intravenous alcohol infusion targeting a final peak breath alcohol concentration of 0.045 g/dL or saline (CS-) infusion at matched rates. On day 2, subjects performed monetary delay discounting outside the scanner to assess delay tolerance and then underwent event-related fMRI while performing the same task with CS+, CS-, and an irrelevant symbol. CS+ elicited stronger activation than CS- in frontoparietal executive/attention and orbitofrontal reward-associated networks. Risk factors including family history, recent drinking, sex, and age of drinking onset did not relate to the [CS+ > CS-] activation. Delay-tolerant choice and [CS+ > CS-] activation in right inferior parietal cortex were positively related. Networks governing executive attention and reward showed enhanced responses to stimuli experimentally paired with intoxication, with the right parietal cortex implicated in both alcohol cue pairing and intertemporal choice. While different from our previous study results in 14 men, we believe this paradigm in a large sample of male and female drinkers offers novel insights into Pavlovian processes less affected by idiosyncratic drug associations.

CognitiveConstruct

ExecutiveAttention

10.1007/s00415-018-8973-x

Journal of neurology

J Neurol

Step length predicts executive dysfunction in Parkinson's disease: a 3-year prospective study.

Cognition and gait appear to be closely related. The chronological interplay between cognitive decline and gait dysfunction is not fully understood. The aim of the present prospective study is investigating whether the dysfunction of specific gait parameters, during specific task and medication conditions, may predict subsequent cognitive impairment in Parkinson's disease (PD). We evaluated cognition and gait in 39 Parkinsonian patients at an initial assessment and after 3 years. Cognitive performance was evaluated with a neuropsychological battery designed to assess memory, executive/attention, and visuospatial domains. Gait was investigated using a gait analysis system during both the off and on states in the following conditions: (1) normal gait; (2) motor dual task; and (3) cognitive dual task. We used regression models to determine whether gait predicts subsequent cognitive dysfunction. Overall, the cognitive test scores were stable over time with the exception of the executive/attention scores, whereas all gait parameters declined. The step length during the cognitive dual task during the on state at the initial evaluation was the only significant predictor of executive/attention domain dysfunction at follow up. The results were confirmed when executive/attention dysfunction at the initial assessment evaluation was included in the regression model as a covariate. Our longitudinal study offers additional insight into the progression of gait dysfunction, and its chronological relationship with cognitive dysfunction in PD patients. In particular, the present study indicates that step length during a cognitive task when on medication is an independent predictor of future executive/attention decline.

CognitiveConstruct

ExecutiveAttention

10.1016/j.nicl.2018.06.005

NeuroImage. Clinical

Neuroimage Clin

Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries.

Alcohol and cannabis are two substances that are commonly abused by adolescents in the United States and which, when abused, are associated with negative medical and psychiatric outcomes across the lifespan. These negative psychiatric outcomes may reflect the detrimental impact of substance abuse on neural systems mediating emotion processing and executive attention. However, work indicative of this has mostly been conducted either in animal models or adults with Alcohol and/or Cannabis Use Disorder (AUD/CUD). Little work has been conducted in adolescent patients. In this study, we used the Affective Stroop task to examine the relationship in 82 adolescents between AUD and/or CUD symptom severity and the functional integrity of neural systems mediating emotional processing and executive attention. We found that AUD symptom severity was related to amygdala responsiveness to emotional stimuli and related to responsiveness within regions implicated in executive attention and response control (i.e., dorsolateral prefrontal cortex, anterior cingulate cortex, precuneus) as a function of task performance. In contrast, CUD symptom severity was unrelated to amygdala responsiveness but related to responsiveness within regions including precuneus, posterior cingulate cortex, and inferior parietal lobule as a function of task performance. These data suggest differential impacts of alcohol and cannabis abuse on the adolescent brain.

CognitiveConstruct

ExecutiveAttention

10.1016/j.cognition.2018.06.022

Cognition

Cognition

Intention, attention and long-term memory for visual scenes: It all depends on the scenes.

Humans have an ability to remember up to 10,000 previously viewed scenes with apparently robust memory for visual detail, a phenomenon that has been interpreted as suggesting a visual memory system of massive capacity. Attempts at explanation have largely focused on the nature of the stimuli and been influenced by theoretical accounts of object recognition. Our own study aims to supplement this by considering two observer-based aspects of visual long-term memory, one strategic, whether the observers are aware or not that their memory will subsequently be tested and the other executive, based on the amount of attentional capacity available during encoding. We describe six studies involving visual scenes ranging in difficulty from complex manmade scenes (d' = 2.54), to door scenes with prominent features removed (d' = 0.79). To ensure processing of the stimuli, all participants have to make a judgement of pleasantness (Experiments 1 and 2) or of the presence or absence of a dot (Experiment 3). Intention to learn influence performance only in the most impoverished condition comprising doors with prominent features removed. Experiments 4-6 investigated the attentional demands of visual long-term memory using a concurrent task procedure. While the demanding task of counting back in threes clearly impaired performance across the range of materials, a lighter load, counting back in ones influences only the most difficult door scenes. Detailed analysis of error patterns indicated that clear differences in performance level between manmade and natural scenes and between unmodified and modified door scenes was reflected in false alarm scores not detections, while concurrent task load affected both. We suggest an interpretation in terms of a two-level process of encoding at the visual feature rather than the whole scene level, with natural images containing many features encoded richly, rapidly and without explicit intent. Only when scenes are selected from a single category and with distinctive detail minimised does memory depend on intention to remember and on the availability of substantial executive capacity.

CognitiveConstruct

ExecutiveAttention

10.1016/j.ntt.2018.06.004

Neurotoxicology and teratology

Neurotoxicol Teratol

An examination of the association between prenatal cocaine exposure and brain activation measures of arousal and attention in young adults: An fMRI study using the Attention Network Task.

Prenatal drug exposure, including cocaine, alcohol, marijuana, and tobacco, is associated with deficits in behavioral regulation and attention. Using fMRI, the objective of this study was to characterize the association between prenatal cocaine exposure (PCE) and the underlying neural substrates associated with behavioral outcomes of attention. Forty-seven young adults were recruited for this study from the ongoing Maternal Health Practices and Child Development (MHPCD) Project, a longitudinal study of the effects of PCE on growth, behavior, and cognitive function. Three groups were compared: 1) prenatal exposure to cocaine, alcohol, marijuana, and tobacco (CAMT, n = 15), 2) prenatal exposure to alcohol, marijuana, and tobacco (AMT, n = 17), and 3) no prenatal exposure to drugs (Controls, n = 15). Subjects were frequency matched on gender, race, handedness, and 15-year IQ. This study used the theoretical model proposed by Posner and Peterson (1990), which posits three dissociable components of attention: alerting, orienting, and executive attention. Subjects completed a functional MRI (fMRI) scan while performing the Attention Network Task, a validated neuroimaging measure of the 3-network model of attention. Behavioral and fMRI data revealed no associations between PCE and task accuracy, speed of processing, or activation in key brain regions associated with each of the attention networks. The results of this study show that any subtle differences in brain function associated with PCE are not detectable using the ANT task and fMRI. These results should be interpreted in the context of other studies that have found associations between PCE and arousal with emotionally arousing stimuli, compared to this study that found no associations using emotionally neutral stimuli.

CognitiveConstruct

ExecutiveAttention

10.3389/fpsyg.2018.00947

Frontiers in psychology

Front Psychol

Profiles of Cognitive-Motor Interference During Walking in Children: Does the Motor or the Cognitive Task Matter?

The evidence supporting the effects of age on the ability to coordinate a motor and a cognitive task show inconsistent results in children and adolescents, where the Dual-Task Effects (DTE) - if computed at all - range from either being lower or comparable or higher in younger children than in older children, adolescents and adults. A feasible reason for the variability in such findings is the wide range of cognitive tasks (and to some extend of motor tasks) used to study Cognitive-Motor Interference (CMI). Our study aims at determining the differences in CMI when performing cognitive tasks targeting different cognitive functions at varying walking pathways. 69 children and adolescents (boys, = 45; girls, = 24; mean age, 11.5 ± 1.50 years) completed higher-level executive function tasks (2-Back, Serial Subtraction, Auditory Stroop, Clock Task, TMT-B) in comparison to non-executive distracter tasks [Motor Response Task (MRT), TMT-A] to assess relative effects on gait during straight vs. repeated Change of Direction (COD) walking. DT during COD walking was assessed using the Trail-Walking-Test (TWT). The motor and cognitive DTE were calculated for each task. There were significant differences between 5th and 8th graders on single gait speed on the straight ( = 0.016) and the COD pathway ( = 0.023), but not on any of the DT conditions. The calculation of DTEs revealed that motor DTEs were lowest for the MRT and highest for the TWT in the numbers/letters condition ( < 0.05 for all comparisons). In contrast, there were cognitive benefits for the higher-order cognitive tasks on the straight pathways, but cognitive costs for both DT conditions on the COD pathway ( < 0.01 for all comparisons). Our findings demonstrate that DT changes in walking when completing a secondary task that involve higher-level cognition are attributable to more than low-level divided attention or motor response processes. These results specifically show the direct competition for higher-level executive function resources important for walking, and are in agreement with previous studies supporting the cognitive-motor link in relation to gait in children. This might be in line with the idea that younger children may not have adequate cognitive resources.

CognitiveConstruct

ExecutiveAttention

10.1089/brain.2017.0574

Brain connectivity

Brain Connect

Brain Network Connectivity and Executive Function in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia.

Chemotherapeutic agents used to treat acute lymphoblastic leukemia (ALL), the most common cancer affecting young children, have been associated with long-term cognitive impairments that reduce quality of life. Executive dysfunction is one of the most consistently observed deficits and can have substantial and pervasive effects on academic success, occupational achievement, psychosocial function, and psychiatric status. We examined the neural mechanisms of executive dysfunction by measuring structural and functional connectomes in 161 long-term survivors of pediatric ALL, age 8-21 years, who were treated on a single contemporary chemotherapy-only protocol for standard/high- or low-risk disease. Lower global efficiency, a measure of information exchange and network integration, of both structural and functional connectomes was found in survivors with executive dysfunction compared with those without dysfunction (p < 0.046). Patients with standard/high- versus low-risk disease and those who received greater number of intrathecal treatments containing methotrexate had the lowest network efficiencies. Patients with executive dysfunction also showed hyperconnectivity in sensorimotor, visual, and auditory-processing regions (p = 0.037) and poor separation between sensorimotor, executive/attention, salience, and default mode networks (p < 0.0001). Connectome disruption was consistent with a pattern of delayed neurodevelopment that may be associated with reduced resilience, adaptability, and flexibility of the brain network. These findings highlight the need for interventions that will prevent or manage cognitive impairment in survivors of pediatric acute lymphoblastic leukemia.

CognitiveConstruct

ExecutiveAttention

10.1016/j.neulet.2018.06.036

Neuroscience letters

Neurosci Lett

The association between visual creativity and cortical thickness in healthy adults.

Creativity is necessary to human survival, human prosperity, civilization and well-being. Visual creativity is an important part of creativity and is the ability to create products of novel and useful visual forms, playing important role in many fields such as art, painting and sculpture. There have been several neuroimaging studies exploring the neural basis of visual creativity. However, to date, little is known about the relationship between cortical structure and visual creativity as measured by the Torrance Tests of Creative Thinking. Here, we investigated the association between cortical thickness and visual creativity in a large sample of 310 healthy adults. We used multiple regression to analyze the correlation between cortical thickness and visual creativity, adjusting for gender, age and general intelligence. The results showed that visual creativity was significantly negatively correlated with cortical thickness in the left middle frontal gyrus (MFG), right inferior frontal gyrus (IFG), right supplementary motor cortex (SMA) and the left insula. These observations have implications for understanding that a thinner prefrontal cortex (PFC) (e.g. IFG, MFG), SMA and insula correspond to higher visual creative performance, presumably due to their role in executive attention, cognitive control, motor planning and dynamic switching.

CognitiveConstruct

ExecutiveAttention

10.1523/ENEURO.0263-17.2018

eNeuro

eNeuro

Differences in Hearing Acuity among "Normal-Hearing" Young Adults Modulate the Neural Basis for Speech Comprehension.

In this paper, we investigate how subtle differences in hearing acuity affect the neural systems supporting speech processing in young adults. Auditory sentence comprehension requires perceiving a complex acoustic signal and performing linguistic operations to extract the correct meaning. We used functional MRI to monitor human brain activity while adults aged 18-41 years listened to spoken sentences. The sentences varied in their level of syntactic processing demands, containing either a subject-relative or object-relative center-embedded clause. All participants self-reported normal hearing, confirmed by audiometric testing, with some variation within a clinically normal range. We found that participants showed activity related to sentence processing in a left-lateralized frontotemporal network. Although accuracy was generally high, participants still made some errors, which were associated with increased activity in bilateral cingulo-opercular and frontoparietal attention networks. A whole-brain regression analysis revealed that activity in a right anterior middle frontal gyrus (aMFG) component of the frontoparietal attention network was related to individual differences in hearing acuity, such that listeners with poorer hearing showed greater recruitment of this region when successfully understanding a sentence. The activity in right aMFGs for listeners with poor hearing did not differ as a function of sentence type, suggesting a general mechanism that is independent of linguistic processing demands. Our results suggest that even modest variations in hearing ability impact the systems supporting auditory speech comprehension, and that auditory sentence comprehension entails the coordination of a left perisylvian network that is sensitive to linguistic variation with an executive attention network that responds to acoustic challenge.

CognitiveConstruct

ExecutiveAttention

10.1891/0889-8391.32.2.140

Journal of cognitive psychotherapy

J Cogn Psychother

A Pilot Study of a 4-Week eHealth-Based Protocol of the Attention Training Technique Component of Metacognitive Therapy Among Patients With Anxiety Disorders.

The attention training technique (ATT) component of metacognitive therapy seeks to reduce anxiety and strengthen executive attention. ATT has the potential to expand mental health service delivery, with researchers labeling ATT as a possible form of eHealth. However, the only known published study to examine ATT in that delivery capacity was not supportive of its use. The current pilot study examined a new 4-week eHealth-based protocol of ATT among a small mixed sample of patients with anxiety disorders ( = 16). Patients attended a single in-person session to practice ATT and then practiced ATT remotely by accessing a standardized recording of ATT through the Internet for 4 weeks. There was no attrition and over 80% of patients achieved the practice benchmark. Improvements were noted across clinician-rated, patient-rated, and performance-based outcomes. Results support further examination of ATT as a possible eHealth treatment for anxiety disorders. Recommendations for future research are discussed.

CognitiveConstruct

ExecutiveAttention

10.1007/s10578-018-0810-z

Child psychiatry and human development

Child Psychiatry Hum Dev

Executive Attention and Empathy-Related Responses in Boys with Oppositional Defiant Disorder or Conduct Disorder, With and Without Comorbid Anxiety Disorder.

This is a first study that investigated the relationships between executive attention-as an important aspect of emotion regulation-and state empathy and sympathy in ODD/CD boys with (N = 31) and without (N = 18) comorbid anxiety disorder (7-12 years). Empathic reactions were evoked using three sadness-inducing film clips. One clip was highly evocative involving a bear cub losing his mother, whilst two other clips were mildly evocative involving children in common childhood situations. Self-reports of empathy and sympathy were collected and executive attention was assessed with a performance task. Poor executive attention skills were associated with less empathy and sympathy, particularly in ODD/CD boys with anxiety and under conditions of a highly evocative stimulus. Our findings support the view that different mechanisms may be involved in empathy problems of ODD/CD children.

CognitiveConstruct

ExecutiveAttention

10.1002/icd.2066

Infant and child development

Infant Child Dev

Executive Attention at Eight Years: Concurrent and Longitudinal Predictors and Individual Differences.

Executive attention, the attention necessary to reconcile conflict among simultaneous attentional demands, is vital to children's daily lives. This attention develops rapidly as the anterior cingulate cortex and prefrontal areas mature during early and middle childhood. However, the developmental course of executive attention is not uniform amongst children. Therefore, the purpose of this investigation was to examine the role of individual differences in the development of executive attention by exploring the concurrent and longitudinal contributions to its development at 8 years of age. Executive attention was predicted by concurrent measures of frontal electroencephalography, lab-based performance on a conflict task, and parent report of attention. Longitudinally, 8-year-old executive attention, was significantly predicted by a combination of 4-year old frontal activity, conflict task performance, and parent report of attention focusing, but not with an analogous equation replacing attention focusing with attention shifting. Together, data demonstrate individual differences in executive attention.

CognitiveConstruct

ExecutiveAttention

10.1016/j.jad.2018.04.064

Journal of affective disorders

J Affect Disord

Temperamental factors in remitted depression: The role of effortful control and attentional mechanisms.

Temperamental effortful control and attentional networks are increasingly viewed as important underlying processes in depression and anxiety. However, it is still unknown whether these factors facilitate depressive and anxiety symptoms in the general population and, more specifically, in remitted depressed individuals. We investigated to what extent effortful control and attentional networks (i.e., Attention Network Task) explain concurrent depressive and anxious symptoms in healthy individuals (n = 270) and remitted depressed individuals (n = 90). Both samples were highly representative of the US population. Increased effortful control predicted a substantial decrease in symptoms of both depression and anxiety in the whole sample, whereas decreased efficiency of executive attention predicted a modest increase in depressive symptoms. Remitted depressed individuals did not show less effortful control nor less efficient attentional networks than healthy individuals. Moreover, clinical status did not moderate the relationship between temperamental factors and either depressive or anxiety symptoms. Limitations include the cross-sectional nature of the study. Our study shows that temperamental effortful control represents an important transdiagnostic process for depressive and anxiety symptoms in adults.

CognitiveConstruct

ExecutiveAttention

10.3389/fped.2018.00071

Frontiers in pediatrics

Front Pediatr

Assessment of Sensory Processing and Executive Functions in Childhood: Development, Reliability, and Validity of the EPYFEI.

The aim of this study was to determine the psychometric properties of the "Assessment of Sensory Processing and Executive Functions in Childhood" (EPYFEI), a questionnaire designed to assess the sensory processing and executive functions of children aged between 3 and 11 years. The EPYFEI was completed by a sample of 1,732 parents of children aged between 3 and 11 years who lived in Spain. An exploratory factor analysis was conducted and showed five main factors: (1) executive attention, working memory, and initiation of actions; (2) general sensory processing; (3) emotional and behavioral self-regulation; (4) supervision, correction of actions, and problem solving; and (5) inhibitory. The reliability of the analysis was high both for the whole questionnaire and for the factors it is composed of. Results provide evidence of the potential usefulness of the EPYFEI in clinical contexts for the early detection of neurodevelopmental disorders, in which there may be a deficit of executive functions and sensory processing.

CognitiveConstruct

ExecutiveAttention

10.1007/s00429-018-1661-x

Brain structure & function

Brain Struct Funct

Frontal cortical control of posterior sensory and association cortices through the claustrum.

The claustrum is a telencephalic gray matter nucleus that is richly interconnected with the neocortex. This structure subserves top-down executive functions that require frontal cortical control of posterior cortical regions. However, functional anatomical support for the claustrum allowing for long-range intercortical communication is lacking. To test this, we performed a channelrhodopsin-assisted long-circuit mapping strategy in mouse brain slices. We find that anterior cingulate cortex input to the claustrum is transiently amplified by claustrum neurons that, in turn, project to parietal association cortex or to primary and secondary visual cortices. Additionally, we observe that claustrum drive of cortical neurons in parietal association cortex is layer-specific, eliciting action potential generation briefly in layers II/III, IV, and VI but not V. These data are the first to provide a functional anatomical substrate through claustrum that may underlie top-down functions, such as executive attention or working memory, providing critical insight to this most interconnected and enigmatic nucleus.

CognitiveConstruct

ExecutiveAttention

10.1177/1745691617720478

Perspectives on psychological science : a journal of the Association for Psychological Science

Perspect Psychol Sci

Working Memory and Executive Attention: A Revisit.

In this follow-up to my 2002 article on working memory capacity, fluid intelligence, and executive attention in Current Directions in Psychological Science, I review even more evidence supporting the idea that the ability to control one's attention (i.e., executive attention) is important to working memory and fluid intelligence. I now argue that working memory tasks reflect primarily the maintenance of information, whereas fluid intelligence tests reflect primarily the ability to disengage from recently attended and no longer useful information. I also point out some conclusions in the 2002 article that now appear to be wrong.

CognitiveConstruct

ExecutiveAttention

10.1016/j.dcn.2018.03.007

Developmental cognitive neuroscience

Dev Cogn Neurosci

Functional network integration and attention skills in young children.

Children acquire attention skills rapidly during early childhood as their brains undergo vast neural development. Attention is well studied in the adult brain, yet due to the challenges associated with scanning young children, investigations in early childhood are sparse. Here, we examined the relationship between age, attention and functional connectivity (FC) during passive viewing in multiple intrinsic connectivity networks (ICNs) in 60 typically developing girls between 4 and 7 years whose sustained, selective and executive attention skills were assessed. Visual, auditory, sensorimotor, default mode (DMN), dorsal attention (DAN), ventral attention (VAN), salience, and frontoparietal ICNs were identified via Independent Component Analysis and subjected to a dual regression. Individual spatial maps were regressed against age and attention skills, controlling for age. All ICNs except the VAN showed regions of increasing FC with age. Attention skills were associated with FC in distinct networks after controlling for age: selective attention positively related to FC in the DAN; sustained attention positively related to FC in visual and auditory ICNs; and executive attention positively related to FC in the DMN and visual ICN. These findings suggest distributed network integration across this age range and highlight how multiple ICNs contribute to attention skills in early childhood.

CognitiveConstruct

ExecutiveAttention

10.1186/s40673-018-0086-x

Cerebellum & ataxias

Cerebellum Ataxias

Spinocerebellar ataxia 17: full phenotype in a 41 CAG/CAA repeats carrier.

Spinocerebellar ataxia 17 (SCA17) is one of the most heterogeneous forms of autosomal dominant cerebellar ataxias with a large clinical spectrum which can mimic other movement disorders such as Huntington disease (HD), dystonia and parkinsonism. SCA17 is caused by an expansion of CAG/CAA repeat in the Tata binding protein () gene. Normal alleles contain 25 to 40 CAG/CAA repeats, alleles with 50 or greater CAG/CAA repeats are pathological with full penetrance. Alleles with 43 to 49 CAG/CAA repeats were also reported and their penetrance is estimated between 50 and 80%. Recently few symptomatic individuals having 41 and 42 repeats were reported but it is still unclear whether CAG/CAA repeats of 41 or 42 are low penetrance disease-causing alleles. Thus, phenotypic variability like the disease course in subject with SCA17 locus restricted expansions remains to be fully understood. The patients was a 63-year-old woman who, at 54 years, showed personality changes and increased frequency of falls. At 55 years of age neuropsychological tests showed executive attention and visuospatial deficit. At the age of 59 the patient developed dysarthria and a progressive cognitive deficit. The neurological examination showed moderate gait ataxia, dysdiadochokinesia and dysmetria, dysphagia, dysarthria and abnormal saccadic pursuit, severe axial asynergy during postural changes, choreiform dyskinesias. Molecular analysis of the gene demonstrated an allele with 41 repeat suggesting that 41 CAG/CCG repeats could be an allele associated with the full clinical spectrum of SCA17. The described case with the other similar cases described in the literature suggests that 41 CAG/CAA trinucleotides should be considered as critical threshold in SCA17. We suggest that SCA17 diagnosis should be suspected in patients presenting with movement disorders associated with other neurodegenerative signs and symptoms.

CognitiveConstruct

ExecutiveAttention

10.3389/fnhum.2018.00060

Frontiers in human neuroscience

Front Hum Neurosci

Functional Dissociation of Latency-Variable, Stimulus- and Response-Locked Target P3 Sub-components in Task-Switching.

Cognitive control warrants efficient task performance in dynamic and changing environments through adjustments in executive attention, stimulus and response selection. The well-known P300 component of the human event-related potential (ERP) has long been proposed to index "context-updating"-critical for cognitive control-in simple target detection tasks. However, task switching ERP studies have revealed both target P3 (300-350 ms) and later sustained P3-like potentials (400-1,200 ms) to first targets ensuing transition cues, although it remains unclear whether these target P3-like potentials also reflect context updating operations. To address this question, we applied novel single-trial EEG analyses-residue iteration decomposition (RIDE)-in order to disentangle target P3 sub-components in a sample of 22 young adults while they either repeated or switched (updated) task rules. The rationale was to revise the context updating hypothesis of P300 elicitation in the light of new evidence suggesting that "the context" consists of not only the sensory units of stimulation, but also associated motor units, and intermediate low- and high-order sensorimotor units, all of which may need to be dynamically updated on a trial by trial basis. The results showed functionally distinct target P3-like potentials in stimulus-locked, response-locked, and intermediate RIDE component clusters overlying parietal and frontal regions, implying multiple functionally distinct, though temporarily overlapping context updating operations. These findings support a reformulated version of the context updating hypothesis, and reveal a rich family of distinct target P3-like sub-components during the reactive control of target detection in task-switching, plausibly indexing the complex and dynamic workings of frontoparietal cortical networks subserving cognitive control.

CognitiveConstruct

ExecutiveAttention

10.1016/j.neuropsychologia.2018.02.027

Neuropsychologia

Neuropsychologia

Neural modulations of interference control over conscious perception.

The relation between attention and consciousness is a highly debated topic in Cognitive Neuroscience. Although there is an agreement about their relationship at the functional level, there is still no consensus about how these two cognitive processes interact at the neural level. According to the gateway hypothesis (Posner, 1994), attention filters the information accessing to consciousness, resulting in both neural and functional modulations. Contrary to this idea, the cumulative influence hypothesis (Tallon-Baudry, 2012) proposes that both attention and consciousness independently impact decision processes about the perception of stimuli. Accordingly, we could observe an interaction between attention and consciousness at the behavioral level, but not at the neural level. Previous studies have shown that alerting and orienting networks of attention modulate participants' ability to verbally report near-threshold visual stimuli both at behavioral and neural levels, supporting the gateway hypothesis over the cumulative influence hypothesis. The impact of the executive control network of attention on conscious perception, however, has only been explored behaviorally (Colás et al., 2017). In the present study, we employed high-density encephalography to investigate the neural basis of the interaction between executive attention and conscious perception. We presented a classical Stroop task concurrently with a detection task of near-threshold stimuli. In two separate sessions, we manipulated the proportion of congruent and incongruent Stroop stimuli. We found that the Stroop-evoked N2 potential (usually associated to conflict detection and localized in the anterior cingulate cortex) was modulated by both conflict detection and conscious perception processes. These results suggest that the relation between executive control and conscious perception lies in frontal lobe regions associated to conflict detection, supporting the gateway hypothesis over the cumulative influence hypothesis.

CognitiveConstruct

ExecutiveAttention

10.1098/rstb.2017.0254

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Philos Trans R Soc Lond B Biol Sci

Temperament and brain networks of attention.

The attention networks of the human brain are important control systems that develop from infancy into adulthood. While they are common to everyone, they differ in efficiency, forming the basis of individual differences in attention. We have developed methods for measuring the efficiency of these networks in older children and adults and have also examined their development from infancy. During infancy the alerting and orienting networks are dominant in control of the infant's actions, but later an executive network dominates. Each network has been associated with its main neuromodulator and these have led to associations with genes related to that network neuromodulator. The links between parent reports of their child's effortful control and the executive attention network allow us to associate molecular mechanisms to fundamental behavioural outcomes.This article is part of the theme issue 'Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'.

CognitiveConstruct

ExecutiveAttention

10.1038/s41598-018-21428-4

Scientific reports

Sci Rep

Working Memory And Brain Tissue Microstructure: White Matter Tract Integrity Based On Multi-Shell Diffusion MRI.

Working memory is a complex cognitive process at the intersection of sensory processing, learning, and short-term memory and also has a general executive attention component. Impaired working memory is associated with a range of neurological and psychiatric disorders, but very little is known about how working memory relates to underlying white matter (WM) microstructure. In this study, we investigate the association between WM microstructure and performance on working memory tasks in healthy adults (right-handed, native English speakers). We combine compartment specific WM tract integrity (WMTI) metrics derived from multi-shell diffusion MRI as well as diffusion tensor/kurtosis imaging (DTI/DKI) metrics with Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) subtests tapping auditory working memory. WMTI is a novel tool that helps us describe the microstructural characteristics in both the intra- and extra-axonal environments of WM such as axonal water fraction (AWF), intra-axonal diffusivity, extra-axonal axial and radial diffusivities, allowing a more biophysical interpretation of WM changes. We demonstrate significant positive correlations between AWF and letter-number sequencing (LNS), suggesting that higher AWF with better performance on complex, more demanding auditory working memory tasks goes along with greater axonal volume and greater myelination in specific regions, causing efficient and faster information process.

CognitiveConstruct

ExecutiveAttention

10.1080/02699931.2018.1438989

Cognition & emotion

Cogn Emot

Effects of emotional content on working memory capacity.

Emotional events tend to be remembered better than neutral events, but emotional states and stimuli may also interfere with cognitive processes that underlie memory performance. The current study investigated the effects of emotional content on working memory capacity (WMC), which involves both short term storage and executive attention control. We tested competing hypotheses in a preregistered experiment (N = 297). The emotional enhancement hypothesis predicts that emotional stimuli attract attention and additional processing resources relative to neutral stimuli, thereby making it easier to encode and store emotional information in WMC. The emotional impairment hypothesis, by contrast, predicts that emotional stimuli interfere with attention control and the active maintenance of information in working memory. Participants completed a common measure of WMC (the operation span task; Turner, M. L., & Engle, R. W. [1989]. Is working memory capacity task dependent? Journal of Memory and Language, 28, 127-154) that included either emotional or neutral words. Results revealed that WMC was reduced for emotional words relative to neutral words, consistent with the emotional impairment hypothesis.

CognitiveConstruct

ExecutiveAttention

10.1007/s12402-018-0251-3

Attention deficit and hyperactivity disorders

Atten Defic Hyperact Disord

Factor structure and clinical correlates of the 61-item Wender Utah Rating Scale (WURS).

The objective of this study was to assess the factor structure and clinical correlates of a 61-item version of the Wender Utah Rating Scale (WURS), a self-report retrospective measure of childhood problems, experiences, and behavior used in ADHD assessment. Given the currently mostly widely used form of the WURS was derived via a criterion-keyed approach, the study aimed to use latent variable modeling of the 61-item WURS to potentially identify more and more homogeneous set of items reflecting current conceptualizations of ADHD symptoms. Exploratory structural equation modeling was used to generate factor scores which were then correlated with neuropsychological measures of intelligence and executive attention as well as a broad measure of personality and emotional functioning. Support for a modified five-factor model was found: ADHD, disruptive mood and behavior, negative affectivity, social confidence, and academic problems. The ADHD factor differed somewhat from the traditional 25-item WURS short form largely through weaker associations with several measures of personality and psychopathology. This study identified a factor more aligned with DSM-5 conceptualization of ADHD as well as measures of other types of childhood characteristics and symptoms which may prove useful for both research and clinical practice.

CognitiveConstruct

ExecutiveAttention

10.1159/000484477

Dementia and geriatric cognitive disorders

Dement Geriatr Cogn Disord

A Methodological Perspective on the Longitudinal Cognitive Change after Stroke.

Most studies of poststroke cognitive impairment (PSCI) have analyzed cognitive levels at specific time points rather than their changes over time. Furthermore, they seldom consider correlations between cognitive domains. We aimed to investigate the effects of these methodological considerations on determining significant PSCI predictors in a longitudinal stroke cohort. In patients who underwent neuropsychological tests at least twice after stroke, we adopted a multilevel hierarchical mixed-effects model with domain-specific cognitive changes and a multivariate model for multiple outcomes to reflect their correlations. We enrolled 375 patients (median follow-up of 34.1 months). Known predictors of PSCI were generally associated with cognitive levels; however, most of the statistical significances disappeared when cognitive changes were set as outcomes, except age for memory, prior stroke and baseline cognition for executive/attention domain, and baseline cognition for visuospatial function. The multivariate analysis which considered multiple outcomes simultaneously further altered these associations. This study shows that defining outcomes as changes over time and reflecting correlations between outcomes may affect the identification of predictors of PSCI.

CognitiveConstruct

ExecutiveAttention

10.1186/s11689-017-9219-4

Journal of neurodevelopmental disorders

J Neurodev Disord

Developmental change in look durations predicts later effortful control in toddlers at familial risk for ASD.

Difficulties with executive functioning (EF) are common in individuals with a range of developmental disorders, including autism spectrum disorder (ASD). Interventions that target underlying mechanisms of EF early in development could be broadly beneficial, but require infant markers of such mechanisms in order to be feasible. Prospective studies of infants at high familial risk (HR) for ASD have revealed a surprising tendency for HR toddlers to show longer epochs of attention to faces than low-risk (LR) controls. In typical development, decreases in look durations towards the end of the first year of life are driven by the development of executive attention-a foundational component of EF. Here, we test the hypothesis that prolonged attention to visual stimuli (including faces) in HR toddlers reflects early differences in the development of executive attention. In a longitudinal prospective study, we used eye-tracking to record HR and LR infants' looking behaviour to social and non-social visual stimuli at ages 9 and 15 months. At age 3 years, we assessed children with a battery of clinical research measures and collected parental report of effortful control (EC)-a temperament trait closely associated with EF and similarly contingent on executive attention. Consistent with previous studies, we found an attenuated reduction in peak look durations to faces between 9 and 15 months for the HR group compared with the LR group, and lower EC amongst the HR-ASD group. In line with our hypothesis, change in peak look duration to faces between 9 and 15 months was negatively associated with EC at age 3. We suggest that for HR toddlers, disruption to the early development of executive attention results in an attenuated reduction in looking time to faces. Effects may be more apparent for faces due to early biases to orient towards them; further, attention difficulties may interact with earlier emerging differences in social information processing. Our finding that prolonged attention to faces may be an early indicator of disruption to the executive attention system is of potential value in screening for infants at risk for later EF difficulties and for evaluation of intervention outcomes.

CognitiveConstruct

ExecutiveAttention

10.3389/fnagi.2017.00350

Frontiers in aging neuroscience

Front Aging Neurosci

Cognitive-Motor Interference during Walking in Older Adults with Probable Mild Cognitive Impairment.

Although several studies have shown that dual-tasking (DT) mobility is impaired in Alzheimer's disease, studies on the effects of DT conditions in probable Mild Cognitive Impairment (pMCI) have not yielded unequivocal results. The objectives of the study were to (1) examine the effect of a concurrent task on a complex walking task in adults with cognitive impairment; and (2) determine whether the effect varied with different difficulty levels of the concurrent task. Furthermore, the study was designed to evaluate the Trail-Walking Test (TWT) as a potential detection tool for MCI. We examined DT performance in 42 young adults (mean age 23.9 ± 1.98), and 43 older adults (mean age 68.2 ± 6.42). The MoCA was used to stratify the subjects into those with and without pMCI. DT was assessed using the TWT: participants completed 5 trials each of walking along a fixed pathway, stepping on targets with increasing sequential numbers (i.e., 1-2-…-15), and increasing sequential numbers and letters (i.e., 1-A-2-B-3-…-8). Motor and cognitive DT effects (DTE) were calculated for each task. ROC curves were used to distinguish younger and healthy older adults from older adults with pMCI. The TWT showed excellent test-retest reliability across all conditions and groups (ICC : 0.83-0.97). SEM% was also low (<11%) as was the MDC95% (<30%). Within the DT conditions, the pMCI group showed significantly longer durations for all tasks regardless of the cognitive load compared to the younger and the healthy older adults. The motor DTEs were greatest for the complex condition in older adults with pMCI more so than in comparison with younger and healthy older adults. ROC analyses confirmed that only the tasks with higher cognitive load could differentiate older adults with pMCI from controls (area under the curve >0.7, < 0.05). The TWT is a reliable DT mobility measure in people with pMCI. However, the condition with high cognitive load is more sensitive than the condition with low cognitive load in identifying pMCI. The TWT-3 thus could serve as a screening tool for early detection of individuals with pMCI. Future studies need to determine the neural correlates for cognitive-motor interference in older adults with pMCI.

CognitiveConstruct

ExecutiveAttention

10.3758/s13420-017-0310-1

Learning & behavior

Learn Behav

Simians in the Shape School: A comparative study of executive attention.

Executive functions (EF) have been studied extensively in children and adults. However, EF tasks for young children can be difficult to administer and interpret. Espy (1997, Developmental Neuropsychology, 13, 495-499) designed the Shape School task to measure inhibition and switching in preschool-aged children. Shape School presents cartoon-like characters that children must flexibly name by their color, their shape, or both, depending on cues that indicate the appropriate rule. Shape School has been found to be age sensitive as well as predictive of performance on other EF tasks. We presented a computerized analogue of Shape School to seven rhesus macaques. Monkeys were trained to categorize characters by color or shape, or to inhibit this response, depending on whether the characters had eyes open, eyes closed, or wore hats. Monkeys performed above chance on the inhibition and switching components of the task. Long runs of a single classification rule and long runs of noninhibition trials had no significant impact on performance when the rule changed or inhibition was required. This nonverbal adaptation of Shape School can measure EF in nonhuman animals and could be used in conjunction with other EF tasks to provide a clearer picture of both human and nonhuman executive functions.

CognitiveConstruct

ExecutiveAttention

10.5334/joc.7

Journal of cognition

J Cogn

Working Memory Capacity as a Determinant of Proactive Interference and Auditory Distraction.

Individual differences in working memory capacity are related to performance on a range of elemental and higher order cognitive tasks. The current experiment tests the assumptions of two theoretical approaches to working memory capacity: working memory as executive attention and working memory as temporary binding. These approaches are examined using a short-term updating task where proactive interference is manipulated, such that old responses have to be suppressed in favour of new responses. A second source of distraction is introduced by way of irrelevant, to-be-ignored background speech that accompanies presentation of the list items. This speech reinforces either the to-be-remembered item on the current list, or the to-be-suppressed item. Working memory capacity was significantly related to overall level of correct performance on the short-term task, and to the degree of proactive interference experienced. However, there was no evidence for individual differences in the ability to suppress the interfering foil, nor in priming effects associated with the irrelevant speech. The results provided little support for the working memory capacity as executive attention perspective, some evidence for the binding perspective, but also evidence supporting the fact that some effects of distraction are not under voluntary control.

CognitiveConstruct

ExecutiveAttention

10.1162/jocn_a_01233

Journal of cognitive neuroscience

J Cogn Neurosci

Contralateral Delay Activity Tracks Fluctuations in Working Memory Performance.

Neural measures of working memory storage, such as the contralateral delay activity (CDA), are powerful tools in working memory research. CDA amplitude is sensitive to working memory load, reaches an asymptote at known behavioral limits, and predicts individual differences in capacity. An open question, however, is whether neural measures of load also track trial-by-trial fluctuations in performance. Here, we used a whole-report working memory task to test the relationship between CDA amplitude and working memory performance. If working memory failures are due to decision-based errors and retrieval failures, CDA amplitude would not differentiate good and poor performance trials when load is held constant. If failures arise during storage, then CDA amplitude should track both working memory load and trial-by-trial performance. As expected, CDA amplitude tracked load (Experiment 1), reaching an asymptote at three items. In Experiment 2, we tracked fluctuations in trial-by-trial performance. CDA amplitude was larger (more negative) for high-performance trials compared with low-performance trials, suggesting that fluctuations in performance were related to the successful storage of items. During working memory failures, participants oriented their attention to the correct side of the screen (lateralized P1) and maintained covert attention to the correct side during the delay period (lateralized alpha power suppression). Despite the preservation of attentional orienting, we found impairments consistent with an executive attention theory of individual differences in working memory capacity; fluctuations in executive control (indexed by pretrial frontal theta power) may be to blame for storage failures.

CognitiveConstruct

ExecutiveAttention

10.1007/s13365-017-0607-z

Journal of neurovirology

J Neurovirol

Neural response to working memory demand predicts neurocognitive deficits in HIV.

Human immunodeficiency virus (HIV) continues to have adverse effects on cognition and the brain in many infected people, despite a reduced incidence of HIV-associated dementia with combined antiretroviral therapy (cART). Working memory is often affected, along with attention, executive control, and cognitive processing speed. Verbal working memory (VWM) requires the interaction of each of the cognitive component processes along with a phonological loop for verbal repetition and rehearsal. HIV-related functional brain response abnormalities during VWM are evident in functional MRI (fMRI), though the neural substrate underlying these neurocognitive deficits is not well understood. The current study addressed this by comparing 24 HIV+ to 27 demographically matched HIV-seronegative (HIV-) adults with respect to fMRI activation on a VWM paradigm (n-back) relative to performance on two standardized tests of executive control, attention and processing speed (Stroop and Trail Making A-B). As expected, the HIV+ group had deficits on these neurocognitive tests compared to HIV- controls, and also differed in neural response on fMRI relative to neuropsychological performance. Reduced activation in VWM task-related brain regions on the 2-back was associated with Stroop interference deficits in HIV+ but not with either Trail Making A or B performance. Activation of the posterior cingulate cortex (PCC) of the default mode network during rest was associated with Hopkins Verbal Learning Test-2 (HVLT-2) learning in HIV+. These effects were not observed in the HIV- controls. Reduced dynamic range of neural response was also evident in HIV+ adults when activation on the 2-back condition was compared to the extent of activation of the default mode network during periods of rest. Neural dynamic range was associated with both Stroop and HVLT-2 performance. These findings provide evidence that HIV-associated alterations in neural activation induced by VWM demands and during rest differentially predict executive-attention and verbal learning deficits. That the Stroop, but not Trail Making was associated with VWM activation suggests that attentional regulation difficulties in suppressing interference and/or conflict regulation are a component of working memory deficits in HIV+ adults. Alterations in neural dynamic range may be a useful index of the impact of HIV on functional brain response and as a fMRI metric in predicting cognitive outcomes.

CognitiveConstruct

ExecutiveAttention

10.1590/1980-57642016dn11-010012

Dementia & neuropsychologia

Dement Neuropsychol

Development and content validity of the CENA Program for Educational Training on the Neuropsychology of Learning, with an emphasis on executive functions and attention.

The importance of executive functions (EF) in childhood development, and their role as indicators of health, well-being, professional and academic success have been demonstrated by several studies in the literature. FE are cognitive processes that aim to control and manage behavior to achieve specific goal and included skills planning, inhibition, cognitive flexibility, (executive) attention and the central executive component of working memory (WM). In the context of education, the EF are crucial for continued learning and efficient academic performance due to their involvement in several components of the educational process. The aim of this article was to describe the development and content validity of the CENA Program for Educational Training on the Neuropsychology of Learning, with an emphasis on executive functions and attention. The study involved seven specialists (four responsible for evaluating the program, and three involved in brainstorming), and was carried out in three stages:Background research: neuropsychology and education;Program development - author brainstorming andEvaluation by expert judges The goals, language and methods. CENA Program were considered adequate, attesting to its content validity as a school-based neuropsychological intervention. Teacher training in school neuropsychology may be an important area for future investment and contribute to academic achievement and student development in the Brazilian education system.

CognitiveConstruct

ExecutiveAttention

10.1089/g4h.2017.0032

Games for health journal

Games Health J

The Feasibility and Potential Impact of Brain Training Games on Cognitive and Emotional Functioning in Middle-Aged Adults.

To investigate whether a commercially available brain training program is feasible to use with a middle-aged population and has a potential impact on cognition and emotional well-being (proof of concept). Fourteen participants (ages 46-55) completed two 6-week training conditions using a crossover (counterbalanced) design: (1) experimental brain training condition and (2) active control "find answers to trivia questions online" condition. A comprehensive neurocognitive battery and a self-report measure of depression and anxiety were administered at baseline (first time point, before training) and after completing each training condition (second time point at 6 weeks, and third time point at 12 weeks). Cognitive composite scores were calculated for participants at each time point. Study completion and protocol adherence demonstrated good feasibility of this brain training protocol in healthy middle-aged adults. Exploratory analyses suggested that brain training was associated with neurocognitive improvements related to executive attention, as well as improvements in mood. Overall, our findings suggest that brain training programs are feasible in middle-aged cohorts. We propose that brain training games may be linked to improvements in executive attention and affect by promoting cognitive self-efficacy in middle-aged adults.

CognitiveConstruct

ExecutiveAttention

10.1177/1550059417742297

Clinical EEG and neuroscience

Clin EEG Neurosci

The Significance of Impulsive Error in Children With ADHD.

A deficit of inhibition ability is a neuropsychological problem in children with attention deficit hyperactivity disorder (ADHD). We investigated whether in children who made impulsive error (IE), less error-related negativity (ERN) would correlate with poorer executive attention functions (EAFs). Ninety children (49 with ADHD and 41 without ADHD) were investigated by a 4-minute simple reaction time task and simultaneous electroencephalogram. When they made IE, the ERN in response-locked event-related potential (ERP) was defined as error awareness. The average area under curve of ERN in the control group with IEs was used as the proper criterion for regrouping the children with ADHD into 2 groups: ADHD children with enough ERN (ADHD-enough ERN) and those with less ERN (ADHD-less ERN). EAFs from Comprehensive Nonverbal Attention Test were used as objective indices, and behavioral questionnaires were used as subjective indices and statistically analyzed within ADHD groups. Forty-eight percent of the children made IEs. ADHD(n = 31, 63%) was significantly more than in the control group (n = 12, 29%; P < .001). The ADHD group had significantly less ERN than did the control group while making IE, especially at frontal and central electrodes ( P < .01). Both ADHD-less ERN and ADHD-enough ERN groups had poorer subjective EAFs on questionnaires. Only the ADHD-less ERN group had significant poorer objective EAFs on the Comprehensive Nonverbal Attention Test than did the ADHD without IE. We conclude that investigating the IE and ERN of IE in children with ADHD might help to differentiate subtypes of ADHD with different neuropsychological abilities, and the possibility that ADHD-less ERN children might be confirmed a meaningful subgroup that needs close follow-up, treatments different from standard, or both.

CognitiveConstruct

ExecutiveAttention

10.1037/edu0000189

Journal of educational psychology

J Educ Psychol

Measuring arithmetic: A psychometric approach to understanding formatting effects and domain specificity.

Using multitrait, multimethod data, and confirmatory factor analysis, the current study examined the effects of arithmetic item formatting and the possibility that across formats, abilities other than arithmetic may contribute to children's answers. Measurement hypotheses were guided by several leading theories of arithmetic cognition. With a sample of 1314 3rd grade students (age M=103.24 months, SD=5.41 months), Abstract Code Theory, Encoding Complex Theory, Triple Code Theory, and the Exact versus Approximate Calculations Hypothesis were evaluated, using 11 measures of arithmetic with symbolic problem formats (e.g., Arabic numeral and language-based formats) and various problem demands (e.g., requiring both exact and approximate calculations). In general, results provided support for both Triple Code Theory and Encoding Complex Theory. As predicted by Triple Code Theory, arithmetic outcomes with language formatting, Arabic numeral formatting, and estimation demands (across formats) were related but distinct from one another. As predicted by Encoding Complex Theory, executive attention was a direct predictor of all arithmetic outcomes. Language was no longer a direct predictor of arithmetic outcomes when executive attention was accounted for in the model; however, a strong and enduring relationship between language and executive attention suggested that language may play a facilitative role in reasoning during numeric processing. These findings have important implications for assessing arithmetic in educational settings and suggest that in addition to arithmetic-focused interventions, interventions targeting executive attention, language, and/or the interplay between them (i.e., internal speech during problem-solving) may be a promising avenues of mathematical problem-solving intervention.

CognitiveConstruct

ExecutiveAttention

10.3389/fpsyg.2017.01725

Frontiers in psychology

Front Psychol

Latent Factors in Attention Emerge from 9 Years of Age among Elementary School Children.

We explored the development of attention among elementary school children. Three hundred and sixty-five primary school children aged 7-12 years completed seven attention tests (alertness, focused attention, divided attention, attentional switching, sustained attention, spatial attention, and supervisory attention). A factor analysis indicated that there was no stable construct of attention among 7- to 8-year-old children. However, from 9 years on, children's attention could be separated into perceptual and executive attention. Notably, however, the attention types included in these two factors differed from those among adults.

CognitiveConstruct

ExecutiveAttention

10.1038/s41598-017-13383-3

Scientific reports

Sci Rep

White noise enhances new-word learning in healthy adults.

Research suggests that listening to white noise may improve some aspects of cognitive performance in individuals with lower attention. This study investigated the impact of white noise on new word learning in healthy young adults, and whether this effect was mediated by executive attention skills. Eighty participants completed a single training session to learn the names of twenty novel objects. The session comprised 5 learning phases, each followed by a recall test. A final recognition test was also administered. Half the participants listened to white noise during the learning phases, and half completed the learning in silence. The noise group demonstrated superior recall accuracy over time, which was not impacted by participant attentional capacity. Recognition accuracy was near ceiling for both groups. These findings suggest that white noise has the capacity to enhance lexical acquisition.

CognitiveConstruct

ExecutiveAttention

10.1080/23279095.2017.1357037

Applied neuropsychology. Adult

Appl Neuropsychol Adult

Effect of transcranial direct current stimulation combined with cognitive training on cognitive functioning in older adults with HIV: A pilot study.

The objective of this study was to examine combination speed of processing (SOP) cognitive remediation therapy (CRT) and transcranial direct stimulation (tDCS) as neurorehabilitation in older HIV+ adults. Thirty-three HIV+ adults aged 50+ completed neurocognitive testing and were randomized to either active (n = 17) or sham (n = 16) tDCS. Both conditions received 10 1-hour sessions of SOP CRT, with either active or sham tDCS for the first 20 minutes. Participants then completed a posttest assessment. Repeated measures analysis of variance examining Time X Condition showed small-to-medium effects in the expected direction for an executive (d = 0.36), and SOP measure (d = 0.49), while medium-to-large effects were observed for an executive/attention (d = 0.60) and oral reading measure (d = 0.75). The only statistically significant interaction was the oral reading measure. Small-to-medium and medium-to-large effects (ds = 0.32, 0.58) were found for two SOP measures in the opposite direction (sham group showing greater improvements). Further trials of CRT and tDCS in this population are needed, including larger samples and a nonactive control and tDCS only condition, as is determination of which parameters of each technique (e.g., tDCS montage, timing of tDCS, domain targeted in CRT, number of sessions) are most effective in improving cognitive outcomes, durability of training gains, and translation to everyday functioning.

CognitiveConstruct

ExecutiveAttention

10.5535/arm.2017.41.4.564

Annals of rehabilitation medicine

Ann Rehabil Med

Relationship Between Cognitive Function and Dysphagia After Stroke.

To investigate the characteristics of cognitive deficits in patients with post-stroke dysphagia, and to analyze the relationships between cognitive dysfunction and severity of dysphagia in supratentorial stroke. A total of 55 patients with first-ever supratentorial lesion stroke were enrolled retrospectively, within 3 months of onset. We rated dysphagia from 0 (normal) to 4 (severe) using the dysphagia severity scale (DSS) through clinical examinations and videofluoroscopic swallowing studies (VFSS). The subjects were classified either as non-dysphagic (scale 0) or dysphagic (scale 1 to 4). We compared general characteristics, stroke severity and the functional scores of the two groups. We then performed comprehensive cognitive function tests and investigated the differences in cognitive performance between the two groups, and analyzed the correlation between cognitive test scores, DSS, and parameters of oral and pharyngeal phase. Fugl-Meyer motor assessment, the Berg Balance Scale, and the Korean version of the Modified Barthel Index showed significant differences between the two groups. Cognitive test scores for the dysphagia group were significantly lower than the non-dysphagia group. Significant correlations were shown between dysphagia severity and certain cognitive subtest scores: visual span backward (p=0.039), trail making tests A (p=0.042) and B (p=0.002), and Raven progressive matrices (p=0.002). The presence of dysphagia was also significantly correlated with cognitive subtests, in particular for visual attention and executive attention (odds ratio [OR]=1.009; 95% confidence interval [CI], 1.002-1.016; p=0.017). Parameters of premature loss were also significantly correlated with the same subtests (OR=1.009; 95% CI, 1.002-1.016; p=0.017). Our results suggest that cognitive function is associated with the presence and severity of post-stroke dysphagia. Above all, visual attention and executive functions may have meaningful influence on the oral phase of swallowing in stroke patients with supratentorial lesions.

CognitiveConstruct

ExecutiveAttention

Nonlinear dynamics, psychology, and life sciences

Nonlinear Dynamics Psychol Life Sci

Applying the Neurodynamics of Emotional Circular Causalities in Psychosocial and Cognitive Therapy using Multi-Sensory Environments: An ORBDE Case Study Analysis.

This exploratory, evidence-based practice research study focuses on presenting a plausible mesoscopic brain dynamics hypothesis for the benefits of treating clients with psychosocial and cognitive challenges using a mindful therapeutic approach and multi-sensory environments. After an extensive neuroscientific review of the therapeutic benefits of mindfulness, a multi-sensory environment is presented as a window of therapeutic opportunity to more quickly and efficiently facilitate the neurobiological experience of becoming more mindful or conscious of self and environment. The complementary relationship between the default mode network and the executive attention network is offered as a neurobiological hypothesis that could explain positive occupational engagement pattern shifts in a case study video of a hospice client with advanced dementia during multi-sensory environment treatment. Orbital Decomposition is used for a video analysis that shows a significant behavioral pattern shift consistent with dampening of the perceptual system attractors that contribute to negative emotional circular causalities in a variety of client populations. This treatment approach may also prove to be valuable for any person who has developed circular causalities due to feelings of isolation, victimization, or abuse. A case is made for broader applications of this intervention that may positively influence perception during the information transfer and processing of hippocampal learning. Future research is called for to determine if positive affective, interpersonal, and occupational engagement pattern shifts during treatment are related to the improved default mode network-executive attention network synchrony characteristic of increased mindfulness.

CognitiveConstruct

ExecutiveAttention

10.3389/fneur.2017.00375

Frontiers in neurology

Front Neurol

REM Sleep Behavior Disorder Is Not Associated with a More Rapid Cognitive Decline in Mild Dementia.

REM sleep behavior disorder (RBD) is associated with cognitive dysfunctions and is a risk factor for development of mild cognitive impairment and dementia. However, it is unknown whether RBD is associated with faster cognitive decline in already established dementia. The main goal of this study was to determine if patients with mild dementia with and without RBD differ in progression rate and in specific neuropsychological measures over 4-year follow-up. This longitudinal, prospective study based on data from the DemVest study compares neuropsychological measures in a mild dementia cohort. A diagnosis of probable RBD (pRBD) was made based on the Mayo Sleep Questionnaire. Neuropsychological domains were assessed by Mini Mental State Examination, total score and figure copying, California Verbal Learning Test-II, Visual Object and Space Perception Cube and Silhouettes, Boston Naming Test, Stroop test, Verbal Category Fluency, Trail Making Test A and B. Among the 246 subjects, 47 (19.1%) had pRBD at the baseline, and pRBD group was younger and with male predominance. During 4-year follow-up, we did not observe any significant differences in the rate of decline in neuropsychological measures. Patients with pRBD performed generally poorer in visuoconstructional, visuoperceptual, and executive/attention tests in comparison to RBD negative. We did not find any significant differences in progression rate of neurocognitive outcomes between dementia patients with and without RBD.

CognitiveConstruct

ExecutiveAttention

10.3389/fnins.2017.00410

Frontiers in neuroscience

Front Neurosci

Mechanism of Cerebralcare Granule® for Improving Cognitive Function in Resting-State Brain Functional Networks of Sub-healthy Subjects.

Cerebralcare Granule® (CG), a Chinese herbal medicine, has been used to ameliorate cognitive impairment induced by ischemia or mental disorders. The ability of CG to improve health status and cognitive function has drawn researchers' attention, but the relevant brain circuits that underlie the ameliorative effects of CG remain unclear. The present study aimed to explore the underlying neurobiological mechanisms of CG in ameliorating cognitive function in sub-healthy subjects using resting-state functional magnetic resonance imaging (fMRI). Thirty sub-healthy participants were instructed to take one 2.5-g package of CG three times a day for 3 months. Clinical cognitive functions were assessed with the Chinese Revised Wechsler Adult Intelligence Scale (WAIS-RC) and Wechsler Memory Scale (WMS), and fMRI scans were performed at baseline and the end of intervention. Functional brain network data were analyzed by conventional network metrics (CNM) and frequent subgraph mining (FSM). Then 21 other sub-healthy participants were enrolled as a blank control group of cognitive functional. We found that administrating CG can improve the full scale of intelligence quotient (FIQ) and Memory Quotient (MQ) scores. At the same time, following CG treatment, in CG group, the topological properties of functional brain networks were altered in various frontal, temporal, occipital cortex regions, and several subcortical brain regions, including essential components of the executive attention network, the salience network, and the sensory-motor network. The nodes involved in the FSM results were largely consistent with the CNM findings, and the changes in nodal metrics correlated with improved cognitive function. These findings indicate that CG can improve sub-healthy subjects' cognitive function through altering brain functional networks. These results provide a foundation for future studies of the potential physiological mechanism of CG.

CognitiveConstruct

ExecutiveAttention

10.1111/ner.12629

Neuromodulation : journal of the International Neuromodulation Society

Neuromodulation

The Effect of Prefrontal Transcranial Direct Current Stimulation on Attention Network Function in Healthy Volunteers.

The effect of acute transcranial direct current stimulation (tDCS) on cortical attention networks remains unclear. We examined the effect of 20 min of 2 mA dorsolateral prefrontal cortex tDCS (bipolar balanced montage) on the efficiency of alerting, orienting and executive attention networks measured by the attention network test. A between-subjects stratified randomized design compared active tDCS vs. sham tDCS on attention network function in healthy young adults. Executive attention was greater following active vs. sham stimulation (d = 0.76) in the absence of effects on alerting, orienting, or global RT or error rates. Group differences were not moderated by state-mood. Twenty minutes of active 2 mA tDCS over left DLPFC is associated with greater executive attention in healthy humans.

CognitiveConstruct

ExecutiveAttention

10.1080/13803395.2017.1342772

Journal of clinical and experimental neuropsychology

J Clin Exp Neuropsychol

Understanding heterogeneity in older adults: Latent growth curve modeling of cognitive functioning.

Clarifying relationships between specific neurocognitive functions in cognitively intact older adults can improve our understanding of mechanisms involved in cognitive decline, which may allow identification of new opportunities for intervention and earlier detection of those at increased risk of dementia. The present study employed latent growth curve modeling to longitudinally examine the relationship between executive attention/processing speed, episodic memory, language, and working memory functioning utilizing the neuropsychological test battery from the National Alzheimer's Disease Coordinating Center. A total of 691 relatively healthy older adults (M = 69.07, SD = 6.49) were assessed at baseline, and 553 individuals completed three visits spanning a two-year period. Better cognitive performance was concomitantly associated with better functioning across domains. Subtle declines in executive attention/processing speed processes were found, while, on average, memory and language performance improved with repeated testing. Lower executive attention/processing speed performance at baseline predicted less incremental growth rate in memory. In turn, higher initial memory functioning was associated with incremental improvements in language performance. These results are consistent with the notion that intact executive function and attention processes are important to preserving memory functioning with advanced age, but are also the functions most susceptible to decline with age. These findings also provide further insight into the critical role of practice effects in clinical assessment practice and have implications for pharmaceutical trials. Practice effects should be routinely considered as they may give the appearance of retention of function within the cognitive domains considered to be a hallmark of Alzheimer's disease pathology.

CognitiveConstruct

ExecutiveAttention

10.3928/01484834-20170619-08

The Journal of nursing education

J Nurs Educ

Meditation's Effect on Attentional Efficiency, Stress, and Mindfulness Characteristics of Nursing Students.

Strengthening attention-regulation efficiency of nurse graduates is important to the quality and safety of nursing practice in increasingly complex and cognitively distracting workplaces. Neuroscientific evidence suggests that regular practice of focused meditation can enhance attentional skills. This study explored meditation as an educational strategy for enhancing nursing students' attentional efficiency. A randomized-control trial with 52 prelicensure nursing students examined differences between those who meditated and those who did not on measurements of alerting, orienting, and executive attention. Stress and mindfulness were also explored. Meditation demonstrated moderate strength for enhancing executive attention, F = 4.26 (1, 49), n = .080, p = .044. Additional outcomes specific to the meditation group were reduced stress and increased mindfulness, F = 7.16 (2, 47), n = .234, p = .002. Results support the consideration of meditation training as a strategy for enhancing nursing students' attentional efficiency and other self-regulatory skills necessary for safe nursing practice. [J Nurs Educ. 2017;56(7):430-434.].

CognitiveConstruct

ExecutiveAttention