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1.0alpha7.train.476
15771353
[ { "id": "1.0alpha7.train.476.sent", "type": "sentence", "text": [ " Since our data suggested that MEIS1 was bound to either HOXA9 and/or PBX1a in the presence of DNA, we wished to study the interactions between these molecules in the absence of a DNA target. " ], "offsets": [ [ 0, 196 ] ] } ]
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1.0alpha7.train.477
5872668
[ { "id": "1.0alpha7.train.477.sent", "type": "sentence", "text": [ " As described by Kumar et al. ( 17), the crystal structure of CtBP bound to NAD+ supports the prediction that CtBP is structurally similar to 3-phosphoglycerate dehydrogenase. " ], "offsets": [ [ 0, 186 ] ] } ]
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1.0alpha7.train.478
2277874
[ { "id": "1.0alpha7.train.478.sent", "type": "sentence", "text": [ "The fact that deletion of domain 7 did not affect the inhibition of osteoclastogenesis (Fig. 2 A) but significantly decreased the binding of OCIF to heparin (Fig. 3) indicates that binding ability of OCIF to heparin does not correlate with its osteoclastogenesis inhibitory activity in vitro." ], "offsets": [ [ 0, 292 ] ] } ]
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1.0alpha7.train.479
864775
[ { "id": "1.0alpha7.train.479.sent", "type": "sentence", "text": [ " Since a peptide encompassing this region binds to collagen type I and inhibits APP-collagen type I binding in nanomolar concentrations, this region may comprise the major part of the collagen type I binding site of APP. " ], "offsets": [ [ 0, 229 ] ] } ]
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[]
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1.0alpha7.train.480
15406437
[ { "id": "1.0alpha7.train.480.sent", "type": "sentence", "text": [ " Figure 5C shows that the binding of Rpb1 (the large subunit of RNA pol II) to both the GAL1 and GAL10 promoters increases with time after induction with galactose, reaching its maximum level at 60 min. " ], "offsets": [ [ 0, 212 ] ] } ]
[ { "id": "1.0alpha7.train.480.ent0_0", "type": "protein-complex", "text": [ "RNA pol II" ], "offsets": [ [ 67, 77 ] ], "normalized": [] }, { "id": "1.0alpha7.train.480.ent1_0", "type": "chemical", "text": [ "galactose" ], "offsets": [ [ 162, 171 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6036" } ] }, { "id": "1.0alpha7.train.480.ent2_0", "type": "protein", "text": [ "Rpb1" ], "offsets": [ [ 39, 43 ] ], "normalized": [] }, { "id": "1.0alpha7.train.480.ent3_0", "type": "DNA", "text": [ "GAL10 promoters" ], "offsets": [ [ 104, 119 ] ], "normalized": [] }, { "id": "1.0alpha7.train.480.ent4_0", "type": "gene", "text": [ "GAL10" ], "offsets": [ [ 104, 109 ] ], "normalized": [] }, { "id": "1.0alpha7.train.480.ent5_0", "type": "DNA", "text": [ "GAL1" ], "offsets": [ [ 93, 97 ] ], "normalized": [] } ]
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1.0alpha7.train.481
1986039
[ { "id": "1.0alpha7.train.481.sent", "type": "sentence", "text": [ "Binding of purified alpha-actinin to the beta1 cytoplasmic domain is shown in Fig. 1 B." ], "offsets": [ [ 0, 90 ] ] } ]
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[]
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1.0alpha7.train.482
11069909
[ { "id": "1.0alpha7.train.482.sent", "type": "sentence", "text": [ "On binding of LPS to TLRs, specifically TLR2 and TLR4, via CD14, a number of molecules are recruited to the receptor to mediate NF-κB activation, which include the adaptor molecule MyD88, the protein kinase IRAK, and the adaptor molecule TRAF-6, thus forming the receptor complex [29], resulting in interaction of downstream molecules and the subsequent activation of NF-κB." ], "offsets": [ [ 0, 374 ] ] } ]
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1.0alpha7.train.483
4311853
[ { "id": "1.0alpha7.train.483.sent", "type": "sentence", "text": [ " Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats. " ], "offsets": [ [ 0, 169 ] ] } ]
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1.0alpha7.train.484
8909102
[ { "id": "1.0alpha7.train.484.sent", "type": "sentence", "text": [ " An N-terminal proline-rich sequence (PXXP) binds to Nck (Bokoch et al., 1996 ; Galisteo et al., 1996 ); a CRIB ( Cdc42/ Rac interactive binding) motif binds to GTP-bound forms of Cdc42 and Rac (Manser et al., 1994 ; Burbelo et al., 1995 ); and a proline-rich motif is constitutively bound to Pix, a guanine nucleotide exchange factor specific to Rac and Cdc42 (Manser et al., 1998 ). " ], "offsets": [ [ 0, 417 ] ] } ]
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[]
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1.0alpha7.train.485
4879462
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[]
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1.0alpha7.train.486
640037
[ { "id": "1.0alpha7.train.486.sent", "type": "sentence", "text": [ " Castanospermine partially blocked the binding of gp160 to calreticulin and calnexin, whereas 1-deoxynojirimycin had little inhibitory effect. " ], "offsets": [ [ 0, 148 ] ] } ]
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[]
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1.0alpha7.train.487
3405495
[ { "id": "1.0alpha7.train.487.sent", "type": "sentence", "text": [ " ( A), Annexin V binding by FACS analysis (apoptotic cells as a %-age of control) ( B), and DNA cleavage (laddering) ( C). " ], "offsets": [ [ 0, 126 ] ] } ]
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[]
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[]
1.0alpha7.train.488
8909808
[ { "id": "1.0alpha7.train.488.sent", "type": "sentence", "text": [ "The ubiquitous expression of Tctex-1 suggests that it may bind to additional cytoplasmic dynein cargo molecules or receptors other than rhodopsin." ], "offsets": [ [ 0, 150 ] ] } ]
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[]
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[]
1.0alpha7.train.489
3199964
[ { "id": "1.0alpha7.train.489.sent", "type": "sentence", "text": [ "We previously determined that the flanking A nucleotides of the AUUUA motifs in the TNFα ARE were essential for binding of TTP to the TNFα ARE (11)." ], "offsets": [ [ 0, 148 ] ] } ]
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[]
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1.0alpha7.train.490
4890087
[ { "id": "1.0alpha7.train.490.sent", "type": "sentence", "text": [ "All of these results and our results are convergent with those of recent studies reporting that dynamin directly binds regulatory components of the actin cytoskeleton, such as profilin (26), proteins of the syndapin/pacsin/FAP52 family (27-29), and cortactin (30)." ], "offsets": [ [ 0, 264 ] ] } ]
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[]
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1.0alpha7.train.491
24668074
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1.0alpha7.train.492
3806869
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1.0alpha7.train.493
4825807
[ { "id": "1.0alpha7.train.493.sent", "type": "sentence", "text": [ "MEP50 binds a subset of the Sm proteins." ], "offsets": [ [ 0, 42 ] ] } ]
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1.0alpha7.train.494
9485931
[ { "id": "1.0alpha7.train.494.sent", "type": "sentence", "text": [ "We find that the fourth repeat is necessary for the F-actin binding activity of cortactin and that the NTA region binds directly to the Arp2/3 complex." ], "offsets": [ [ 0, 155 ] ] } ]
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1.0alpha7.train.495
1551561
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1.0alpha7.train.496
2063195
[ { "id": "1.0alpha7.train.496.sent", "type": "sentence", "text": [ " On the other hand, fascin inhibits actin binding of cultured cell TM, when caldesmon is absent. " ], "offsets": [ [ 0, 102 ] ] } ]
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1.0alpha7.train.497
3194889
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1.0alpha7.train.498
21460729
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1.0alpha7.train.499
54841
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1.0alpha7.train.500
2913618
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1.0alpha7.train.501
25150848
[ { "id": "1.0alpha7.train.501.sent", "type": "sentence", "text": [ "(C) Binding of n-sec1 to syntaxin 1a in the presence of 1 mM S-NC." ], "offsets": [ [ 0, 69 ] ] } ]
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1.0alpha7.train.502
4848653
[ { "id": "1.0alpha7.train.502.sent", "type": "sentence", "text": [ " Therefore, the DERK binding ability of DMKP-3, which involved DERK sequestration within the cytosol, is essential to inhibit insulin-stimulated cell proliferation. " ], "offsets": [ [ 0, 169 ] ] } ]
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1.0alpha7.train.503
9119520
[ { "id": "1.0alpha7.train.503.sent", "type": "sentence", "text": [ " Daam1 exhibits little, if any, binding to Rac or Cdc42, whereas PAK (p21 activated kinase) binds to either GTP-loaded Rac or Cdc42, but not Rho (Figure 2F). " ], "offsets": [ [ 0, 172 ] ] } ]
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1.0alpha7.train.504
7501553
[ { "id": "1.0alpha7.train.504.sent", "type": "sentence", "text": [ "Cortactin binds Arp2/3 complex with micromolar affinity ( 27A) and activates nucleation through Arp2/3 complex ( 27B, 27C), although maximal activation is weak compared to WASp/Scar WA." ], "offsets": [ [ 0, 189 ] ] } ]
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1.0alpha7.train.505
10277183
[ { "id": "1.0alpha7.train.505.sent", "type": "sentence", "text": [ " The more widely used PKC inhibitor, H-7, which interferes with ATP binding to PKC, 31 also suppresses proliferation of HEC induced by bFGF; an H-7 concentration of 26 mumol/L produces half-maximal inhibition (Fig 3 ). " ], "offsets": [ [ 0, 229 ] ] } ]
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[]
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1.0alpha7.train.506
12760613
[ { "id": "1.0alpha7.train.506.sent", "type": "sentence", "text": [ " Furthermore, binding of Smad3 to CBP was direct, as purified GST-CBP1891-2175, but not GST, interacted with bacterially expressed, purified Smad3210-425 (Fig. 2D). " ], "offsets": [ [ 0, 171 ] ] } ]
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[]
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1.0alpha7.train.507
19710037
[ { "id": "1.0alpha7.train.507.sent", "type": "sentence", "text": [ " Baker et al. (Baker et al., 2001 ) show in vitro experiments in which MAE binding to PNT-P2 leads to activation of transcription, and assume that this occurs via MAE promoting MAPK phosphorylation, and hence activation, of PNT-P2. " ], "offsets": [ [ 0, 239 ] ] } ]
[ { "id": "1.0alpha7.train.507.ent0_0", "type": "protein-family", "text": [ "MAPK" ], "offsets": [ [ 182, 186 ] ], "normalized": [ { "db_name": "intenz", "db_id": "https://www.ebi.ac.uk/intenz/query?cmd" } ] }, { "id": "1.0alpha7.train.507.ent1_0", "type": "protein-isoform", "text": [ "PNT-P2" ], "offsets": [ [ 89, 95 ] ], "normalized": [] }, { "id": "1.0alpha7.train.507.ent2_1", "type": "protein-isoform", "text": [ "PNT-P2" ], "offsets": [ [ 230, 236 ] ], "normalized": [] }, { "id": "1.0alpha7.train.507.ent3_0", "type": "protein", "text": [ "MAE" ], "offsets": [ [ 73, 76 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6529" }, { "db_name": "hgnc", "db_id": "SLC6A1" }, { "db_name": "uniprot", "db_id": "P30531" } ] }, { "id": "1.0alpha7.train.507.ent4_1", "type": "protein", "text": [ "MAE" ], "offsets": [ [ 167, 170 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6529" }, { "db_name": "hgnc", "db_id": "SLC6A1" }, { "db_name": "uniprot", "db_id": "P30531" } ] }, { "id": "1.0alpha7.train.507.ent5_0", "type": "protein", "text": [ "PNT" ], "offsets": [ [ 89, 92 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P51023" } ] }, { "id": "1.0alpha7.train.507.ent6_1", "type": "protein", "text": [ "PNT" ], "offsets": [ [ 230, 233 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P51023" } ] } ]
[]
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1.0alpha7.train.508
11580525
[ { "id": "1.0alpha7.train.508.sent", "type": "sentence", "text": [ " Profilin binds actin monomers and appears to regulate microfilament assembly ( Schluter et al., 1997). " ], "offsets": [ [ 0, 107 ] ] } ]
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[]
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1.0alpha7.train.509
15558507
[ { "id": "1.0alpha7.train.509.sent", "type": "sentence", "text": [ "Briefly, GST or GST-dFMR1 (2 μg) bound to 30 μl of glutathione-Sepharose 4B resin (Pharmacia) was incubated with 5 μl of the in vitro-translated proteins in 500 μl of binding buffer (50 mM Tris-HCl [pH 7.5], 200 mM NaCl, 2 mM EDTA, 0.1% NP-40, 1 μg of leupeptin/ml, 1 μg of pepstatin A/ml, 0.5% aprotinin)." ], "offsets": [ [ 0, 306 ] ] } ]
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[]
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[]
1.0alpha7.train.510
4316007
[ { "id": "1.0alpha7.train.510.sent", "type": "sentence", "text": [ " To test this hypothesis, we have examined the interaction of Arp1 with the Golgi-associated betaIII isoform of spectrin and demonstrated that Arp1 binds directly to betaIII spectrin. " ], "offsets": [ [ 0, 189 ] ] } ]
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[]
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1.0alpha7.train.511
4878420
[ { "id": "1.0alpha7.train.511.sent", "type": "sentence", "text": [ " Immunoblotting with rabbit anti-human galectin-1 polyclonal antibody revealed the 58-kDa Dmgal band (Fig. 3 D, lanes 6 and 7), demonstrating that native Dmgal binds beta-lactose. " ], "offsets": [ [ 0, 187 ] ] } ]
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[]
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1.0alpha7.train.512
1976359
[ { "id": "1.0alpha7.train.512.sent", "type": "sentence", "text": [ "The implication was that negative charge at the PKA site enhances recognition of the Dorsal NLS by the importin complex, and that the PKA site may be directly involved in NLS binding by importin." ], "offsets": [ [ 0, 195 ] ] } ]
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[]
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1.0alpha7.train.513
19133531
[ { "id": "1.0alpha7.train.513.sent", "type": "sentence", "text": [ "The reason for the lower species shift may be that inhibition of binding between Sp1 and Ets-1 induces instability of Ets-1-binding to the -64/-44 probe." ], "offsets": [ [ 0, 156 ] ] } ]
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[]
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1.0alpha7.train.514
4576284
[ { "id": "1.0alpha7.train.514.sent", "type": "sentence", "text": [ " In contrast to the model previously proposed ( 44), however, we found that paxillin alpha could bind directly to PAK3. " ], "offsets": [ [ 0, 123 ] ] } ]
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[]
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1.0alpha7.train.515
9632799
[ { "id": "1.0alpha7.train.515.sent", "type": "sentence", "text": [ "Bni1p binds to the actin-binding proteins, Bud6p and profilin (Evangelista et al., 1997; Imamura et al., 1997) and is a target of the rho-related GTPases, Cdc42p and Rho1p (Kohno et al., 1996; Evangelista et al., 1997; Imamura et al., 1997)." ], "offsets": [ [ 0, 241 ] ] } ]
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[]
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1.0alpha7.train.516
5026175
[ { "id": "1.0alpha7.train.516.sent", "type": "sentence", "text": [ " Other myosins bind actin in the presence of ATP with equilibrium dissociation constants <50 muM at low ionic strength conditions ( 36, 37), whereas myo1eIQ clearly binds with a dissociation constant > 50 muM (Fig. 2). " ], "offsets": [ [ 0, 228 ] ] } ]
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[]
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1.0alpha7.train.517
18104698
[ { "id": "1.0alpha7.train.517.sent", "type": "sentence", "text": [ "This is consistent with the greater inhibitory effect of SR1 on FGF2-induced proliferation and FGF2 binding in RPE cells and is consistent with previous work showing that the human soluble receptor preferentially binds FGF2 over FGF1 (Duan et al." ], "offsets": [ [ 0, 254 ] ] } ]
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[]
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[]
1.0alpha7.train.518
8669390
[ { "id": "1.0alpha7.train.518.sent", "type": "sentence", "text": [ " Complicating such studies is the fact that, in many perinatal rodents, E2 is much less potent than DES as an estrogen due to high serum concentrations of alpha-fetoprotein (AFP), which binds E2 but not DES with high affinity [ 17]. " ], "offsets": [ [ 0, 239 ] ] } ]
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1.0alpha7.train.519
18209686
[ { "id": "1.0alpha7.train.519.sent", "type": "sentence", "text": [ " The dissociation equilibrium constant ( Kd) for profilin binding actin was determined from the dependence of k 1 on profilin concentration (Figure 5, A and B). " ], "offsets": [ [ 0, 168 ] ] } ]
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[]
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1.0alpha7.train.520
16264797
[ { "id": "1.0alpha7.train.520.sent", "type": "sentence", "text": [ "Cdc20 also binds to the APC and presumably activates Pds1 ubiquitination." ], "offsets": [ [ 0, 75 ] ] } ]
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[]
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1.0alpha7.train.521
3406966
[ { "id": "1.0alpha7.train.521.sent", "type": "sentence", "text": [ "Because HSP47 binds in vitro to various types of collagen (at least types I-V; Ref. 4), as well as to collagen-like proteins such as C1q,3 it appears that HSP47 may function through specific binding to the helix-forming portions of procollagen." ], "offsets": [ [ 0, 244 ] ] } ]
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[]
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1.0alpha7.train.522
15706092
[ { "id": "1.0alpha7.train.522.sent", "type": "sentence", "text": [ "These results indicate that direct cooperative interactions between RAP1 and GCN4 at the HIS4 promoter are very unlikely and support the idea that RAP1 binding to the HIS4 promoter facilitates GCN4 binding by overcoming the repressive effect of chromatin." ], "offsets": [ [ 0, 255 ] ] } ]
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[]
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1.0alpha7.train.523
5552575
[ { "id": "1.0alpha7.train.523.sent", "type": "sentence", "text": [ "The intersection of the fit lines on the 1/velocity axis, K is = 25 ± 10 nM, suggests that GC-boxbMET and AdoMet bind competitively to the same poly(dI.dC)-bound form of the enzyme but not necessarily to the same site on the enzyme." ], "offsets": [ [ 0, 232 ] ] } ]
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[]
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[]
1.0alpha7.train.524
15771298
[ { "id": "1.0alpha7.train.524.sent", "type": "sentence", "text": [ " In a similar manner, the binding of MEIS1 to HOXA9 was increased fivefold in the presence of PBX2 (compare lane 15 with lane 14). " ], "offsets": [ [ 0, 135 ] ] } ]
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[]
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1.0alpha7.train.525
16353004
[ { "id": "1.0alpha7.train.525.sent", "type": "sentence", "text": [ "PSD-95 binds to neuroligins via its third PDZ domain and recruits to the junction NMDA2 receptors and K+ channels that bind to the other PDZ domains." ], "offsets": [ [ 0, 152 ] ] } ]
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[]
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1.0alpha7.train.526
12689159
[ { "id": "1.0alpha7.train.526.sent", "type": "sentence", "text": [ " However, GSK-3beta does not bind directly to beta-catenin, and efficient in vitro phosphorylation of beta-catenin by GSK-3beta requires the presence of Axin, which binds both proteins (Ikeda et al. 1998 ). " ], "offsets": [ [ 0, 214 ] ] } ]
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[]
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1.0alpha7.train.527
3741029
[ { "id": "1.0alpha7.train.527.sent", "type": "sentence", "text": [ "Electrophoretic mobility shift assays with in vitro transcribed and translated ARNT and EPAS1 binding to the HIF1-binding site were performed as described (28). " ], "offsets": [ [ 0, 161 ] ] } ]
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[]
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1.0alpha7.train.528
6233726
[ { "id": "1.0alpha7.train.528.sent", "type": "sentence", "text": [ " Although Arg binding to F-actin saturates at a ratio of one Arg/two actin molecules, Arg688-1182 seems to bind to F-actin at a much lower density of approximately one Arg688-1182/five actin molecules. " ], "offsets": [ [ 0, 209 ] ] } ]
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[]
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"arg1_id": "1.0alpha7.train.528.ent1_1", "arg2_id": "1.0alpha7.train.528.ent7_3", "normalized": [] } ]
1.0alpha7.train.529
9170184
[ { "id": "1.0alpha7.train.529.sent", "type": "sentence", "text": [ " While the central region of s-synaphin bound to syntaxin, no binding was detected to the NH2- or COOH-terminal constructs (Figure 2C). " ], "offsets": [ [ 0, 145 ] ] } ]
[ { "id": "1.0alpha7.train.529.ent0_0", "type": "protein", "text": [ "s-synaphin" ], "offsets": [ [ 30, 40 ] ], "normalized": [] }, { "id": "1.0alpha7.train.529.ent1_0", "type": "protein-family", "text": [ "syntaxin" ], "offsets": [ [ 51, 59 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00804" } ] } ]
[]
[ { "id": "1.0alpha7.train.529.coref0", "entity_ids": [ "1.0alpha7.train.529.ent0_0" ] }, { "id": "1.0alpha7.train.529.coref1", "entity_ids": [ "1.0alpha7.train.529.ent1_0" ] } ]
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1.0alpha7.train.530
11107234
[ { "id": "1.0alpha7.train.530.sent", "type": "sentence", "text": [ "BMP-7 binding to ROS 17/2." ], "offsets": [ [ 0, 27 ] ] } ]
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[]
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[]
1.0alpha7.train.531
6370202
[ { "id": "1.0alpha7.train.531.sent", "type": "sentence", "text": [ "This fragment of eIF4G binds both eIF4E and eIF4A and probably coordinates their activities so that a cap-proximal region of mRNA is unwound and is thus rendered accessible to an incoming 43S complex so it can bind productively." ], "offsets": [ [ 0, 231 ] ] } ]
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[]
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1.0alpha7.train.532
22276975
[ { "id": "1.0alpha7.train.532.sent", "type": "sentence", "text": [ "However, our current results clearly suggest that the previously reported ANG II stimulation of TGF-β1 transcription in MCT cells is rather inhibited by concomitant induction of oxygen radicals and may involve transcription factors other than the Sp1 binding sequence in the TGF-β1 enhancer/promoter. " ], "offsets": [ [ 0, 301 ] ] } ]
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[]
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1.0alpha7.train.533
11521301
[ { "id": "1.0alpha7.train.533.sent", "type": "sentence", "text": [ "As expected, binding of ORC to hamster metaphase chromatin incubated in Xenopus egg extract preceded binding of Mcm proteins, and binding of Mcm proteins preceded binding of proliferating cell nuclear antigen (PCNA), which was accompanied by DNA replication (Figure 4A and B)." ], "offsets": [ [ 0, 276 ] ] } ]
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[]
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[]
1.0alpha7.train.534
24539764
[ { "id": "1.0alpha7.train.534.sent", "type": "sentence", "text": [ " We suggest that PHO binds to PREs and, in conjunction with other unidentified DNA binding proteins, recruits PcG proteins to the DNA. " ], "offsets": [ [ 0, 140 ] ] } ]
[ { "id": "1.0alpha7.train.534.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 82, 85 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.534.ent1_1", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 134, 137 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.534.ent2_0", "type": "protein-complex", "text": [ "PcG proteins" ], "offsets": [ [ 114, 126 ] ], "normalized": [] }, { "id": "1.0alpha7.train.534.ent3_0", "type": "protein-complex", "text": [ "PcG" ], "offsets": [ [ 114, 117 ] ], "normalized": [] }, { "id": "1.0alpha7.train.534.ent4_0", "type": "protein", "text": [ "PHO" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q8ST83" } ] }, { "id": "1.0alpha7.train.534.ent5_0", "type": "DNA", "text": [ "PREs" ], "offsets": [ [ 32, 36 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.535
15260107
[ { "id": "1.0alpha7.train.535.sent", "type": "sentence", "text": [ "We may conclude that GAGA factor binds to (CT)n repeats independently of TBP binding and facilitates binding of the latter directly or indirectly." ], "offsets": [ [ 0, 148 ] ] } ]
[ { "id": "1.0alpha7.train.535.ent0_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 75, 78 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.535.ent1_0", "type": "protein", "text": [ "GAGA factor" ], "offsets": [ [ 22, 33 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q08605" } ] }, { "id": "1.0alpha7.train.535.ent2_0", "type": "DNA", "text": [ "(CT)n repeats" ], "offsets": [ [ 43, 56 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.536
15810775
[ { "id": "1.0alpha7.train.536.sent", "type": "sentence", "text": [ " U2AF65 binds directly to Py tracts ( 41), while U2AF35 is tethered to the pre-mRNA through its interaction with U2AF65 ( 42). " ], "offsets": [ [ 0, 132 ] ] } ]
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[]
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1.0alpha7.train.537
11286084
[ { "id": "1.0alpha7.train.537.sent", "type": "sentence", "text": [ " In mammals, however, there has been no evidence that eIF4G binds PABP. " ], "offsets": [ [ 0, 76 ] ] } ]
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[]
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1.0alpha7.train.538
3190668
[ { "id": "1.0alpha7.train.538.sent", "type": "sentence", "text": [ " According to crystallographic studies of a PD bound to a PAX6 consensus binding site, neither of these mutations is involved in direct DNA contact ( 23). " ], "offsets": [ [ 0, 158 ] ] } ]
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[]
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1.0alpha7.train.539
4249976
[ { "id": "1.0alpha7.train.539.sent", "type": "sentence", "text": [ " It was also shown that the GST-A box of HMG-1 was able to pull down TFIID in crude HeLa extract, suggesting that HMG-1 binds to TBP and/or other TFIID components ( 41). " ], "offsets": [ [ 0, 177 ] ] } ]
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1.0alpha7.train.540
9742495
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1.0alpha7.train.541
3393175
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1.0alpha7.train.542
17859517
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1.0alpha7.train.543
910361
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[]
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1.0alpha7.train.544
24764904
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[]
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1.0alpha7.train.545
2853996
[ { "id": "1.0alpha7.train.545.sent", "type": "sentence", "text": [ "These observations suggest that the amino-terminal domain regulates PI binding to APP and that the carboxyl-terminal domain containing PDZ motifs is essential to modulate APP processing." ], "offsets": [ [ 0, 189 ] ] } ]
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[]
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1.0alpha7.train.546
23794628
[ { "id": "1.0alpha7.train.546.sent", "type": "sentence", "text": [ "To address the relative contributions of [3H]BTA-1 binding to Aβ and tau deposits in the frontal gray of AD brain we compared [3H]BTA-1 binding in homogenates from entorhinal cortex, frontal gray, and cerebellum from a typical Braak stage VI AD brain (Table 1, AD 01) and a Braak stage II control brain (Table 1, Cntl 04), matched for age and postmortem interval." ], "offsets": [ [ 0, 363 ] ] } ]
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[]
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1.0alpha7.train.547
13774575
[ { "id": "1.0alpha7.train.547.sent", "type": "sentence", "text": [ " Rho-kinase and the myosin-binding subunit of myosin phosphatase, two downstream targets of Rho, interact with ERM proteins and myosin light chain (MLC), resulting in their phosphorylation. " ], "offsets": [ [ 0, 196 ] ] } ]
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[]
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1.0alpha7.train.548
6510425
[ { "id": "1.0alpha7.train.548.sent", "type": "sentence", "text": [ "A potential mechanism by which CBP repressed TCF-mediated transcription of Ubx was that CBP-mediated acetylation of TCF decreased the affinity of TCF's binding to Armadillo." ], "offsets": [ [ 0, 181 ] ] } ]
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[]
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1.0alpha7.train.549
11313011
[ { "id": "1.0alpha7.train.549.sent", "type": "sentence", "text": [ "Though PAK binds to activated Rac1, recent investigations demonstrated that the activity of the PAK kinase is not correlated with the cytoskeletal rearrangements induced by Rac1 (Joneson et al., 1996; Lamarche et al., 1996; Sells et al., 1997) and rather is linked to the activation of JNK (Bagrodia et al., 1995), supporting the proposed signalling pathway (Figure 7)." ], "offsets": [ [ 0, 369 ] ] } ]
[ { "id": "1.0alpha7.train.549.ent0_0", "type": "protein", "text": [ "JNK" ], "offsets": [ [ 286, 289 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5599" }, { "db_name": "hgnc", "db_id": "MAPK8" }, { "db_name": "uniprot", "db_id": "P45983" } ] }, { "id": "1.0alpha7.train.549.ent1_0", "type": "protein-family", "text": [ "PAK kinase" ], "offsets": [ [ 96, 106 ] ], "normalized": [] }, { "id": "1.0alpha7.train.549.ent2_0", "type": "protein-family", "text": [ "PAK" ], "offsets": [ [ 7, 10 ] ], "normalized": [] }, { "id": "1.0alpha7.train.549.ent3_1", "type": "protein-family", "text": [ "PAK" ], "offsets": [ [ 96, 99 ] ], "normalized": [] }, { "id": "1.0alpha7.train.549.ent4_0", "type": "protein", "text": [ "Rac1" ], "offsets": [ [ 30, 34 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5879" }, { "db_name": "hgnc", "db_id": "RAC1" }, { "db_name": "uniprot", "db_id": "P63000" } ] }, { "id": "1.0alpha7.train.549.ent5_1", "type": "protein", "text": [ "Rac1" ], "offsets": [ [ 173, 177 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5879" }, { "db_name": "hgnc", "db_id": "RAC1" }, { "db_name": "uniprot", "db_id": "P63000" } ] } ]
[]
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1.0alpha7.train.550
2046243
[ { "id": "1.0alpha7.train.550.sent", "type": "sentence", "text": [ " mAb 1 inhibited the binding of DREF to DRE-P, and mAb 4 supershifted the band with DRE-P ( 20, 28) (Fig. 5 C, lanes 10-12). " ], "offsets": [ [ 0, 133 ] ] } ]
[ { "id": "1.0alpha7.train.550.ent0_0", "type": "reagent", "text": [ "mAb 4" ], "offsets": [ [ 54, 59 ] ], "normalized": [] }, { "id": "1.0alpha7.train.550.ent1_0", "type": "reagent", "text": [ "mAb 1" ], "offsets": [ [ 1, 6 ] ], "normalized": [] }, { "id": "1.0alpha7.train.550.ent2_0", "type": "DNA", "text": [ "DRE-P" ], "offsets": [ [ 42, 47 ] ], "normalized": [] }, { "id": "1.0alpha7.train.550.ent3_1", "type": "DNA", "text": [ "DRE-P" ], "offsets": [ [ 88, 93 ] ], "normalized": [] }, { "id": "1.0alpha7.train.550.ent4_0", "type": "protein", "text": [ "DREF" ], "offsets": [ [ 33, 37 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9189" }, { "db_name": "hgnc", "db_id": "ZBED1" }, { "db_name": "uniprot", "db_id": "O96006" } ] } ]
[]
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1.0alpha7.train.551
2371050
[ { "id": "1.0alpha7.train.551.sent", "type": "sentence", "text": [ " We have found that both Axin and Axil bind not only to GSK-3beta but also to beta-catenin and that they promote GSK-3beta-dependent phosphorylation of beta-catenin ( 11, 12). " ], "offsets": [ [ 0, 184 ] ] } ]
[ { "id": "1.0alpha7.train.551.ent0_0", "type": "protein", "text": [ "Axil" ], "offsets": [ [ 36, 40 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8313" }, { "db_name": "hgnc", "db_id": "AXIN2" }, { "db_name": "uniprot", "db_id": "A0A087WXP8" } ] }, { "id": "1.0alpha7.train.551.ent1_0", "type": "protein-family", "text": [ "beta-catenin" ], "offsets": [ [ 82, 94 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR013284" } ] }, { "id": "1.0alpha7.train.551.ent2_1", "type": "protein-family", "text": [ "beta-catenin" ], "offsets": [ [ 158, 170 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR013284" } ] }, { "id": "1.0alpha7.train.551.ent3_0", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 26, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.551.ent4_0", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 59, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] }, { "id": "1.0alpha7.train.551.ent5_1", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 118, 127 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] } ]
[]
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1.0alpha7.train.552
17933404
[ { "id": "1.0alpha7.train.552.sent", "type": "sentence", "text": [ "The WD-40 repeats have a self-inhibitory effect on the rest of the protein, and binding of dATP and cytochrome c to Apaf-1 antagonizes this inhibitory effect and allows Apaf-1 self-aggregation as well as Apaf-1 binding to procaspase-9 (124, 193, 269) (Fig. ​(Fig.6A).6A)." ], "offsets": [ [ 0, 271 ] ] } ]
[ { "id": "1.0alpha7.train.552.ent0_0", "type": "protein", "text": [ "procaspase-9" ], "offsets": [ [ 222, 234 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "842" }, { "db_name": "hgnc", "db_id": "CASP9" }, { "db_name": "uniprot", "db_id": "P55211" } ] }, { "id": "1.0alpha7.train.552.ent1_0", "type": "protein", "text": [ "Apaf-1" ], "offsets": [ [ 116, 122 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "317" }, { "db_name": "hgnc", "db_id": "APAF1" }, { "db_name": "uniprot", "db_id": "O14727" } ] }, { "id": "1.0alpha7.train.552.ent2_1", "type": "protein", "text": [ "Apaf-1" ], "offsets": [ [ 169, 175 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "317" }, { "db_name": "hgnc", "db_id": "APAF1" }, { "db_name": "uniprot", "db_id": "O14727" } ] }, { "id": "1.0alpha7.train.552.ent3_2", "type": "protein", "text": [ "Apaf-1" ], "offsets": [ [ 204, 210 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "317" }, { "db_name": "hgnc", "db_id": "APAF1" }, { "db_name": "uniprot", "db_id": "O14727" } ] }, { "id": "1.0alpha7.train.552.ent4_0", "type": "protein", "text": [ "cytochrome c" ], "offsets": [ [ 100, 112 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "54205" }, { "db_name": "hgnc", "db_id": "CYCS" }, { "db_name": "uniprot", "db_id": "P99999" } ] }, { "id": "1.0alpha7.train.552.ent5_0", "type": "protein-region", "text": [ "WD-40 repeats" ], "offsets": [ [ 4, 17 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR036322" } ] }, { "id": "1.0alpha7.train.552.ent6_0", "type": "chemical", "text": [ "dATP" ], "offsets": [ [ 91, 95 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "15993" } ] } ]
[]
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1.0alpha7.train.553
3397409
[ { "id": "1.0alpha7.train.553.sent", "type": "sentence", "text": [ " The presentation is based on the binding data of fH for C3b, C3c, and C3d shown in Figs. 4 and 6. " ], "offsets": [ [ 0, 106 ] ] } ]
[ { "id": "1.0alpha7.train.553.ent0_0", "type": "protein", "text": [ "fH" ], "offsets": [ [ 51, 53 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2271" }, { "db_name": "hgnc", "db_id": "FH" }, { "db_name": "uniprot", "db_id": "P07954" } ] }, { "id": "1.0alpha7.train.553.ent1_0", "type": "protein", "text": [ "C3d" ], "offsets": [ [ 75, 78 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1380" }, { "db_name": "hgnc", "db_id": "CR2" }, { "db_name": "uniprot", "db_id": "P20023" } ] }, { "id": "1.0alpha7.train.553.ent2_0", "type": "protein", "text": [ "C3c" ], "offsets": [ [ 65, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "718" }, { "db_name": "hgnc", "db_id": "C3" }, { "db_name": "uniprot", "db_id": "P01024" } ] }, { "id": "1.0alpha7.train.553.ent3_0", "type": "protein", "text": [ "C3b" ], "offsets": [ [ 59, 62 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "718" }, { "db_name": "hgnc", "db_id": "C3" }, { "db_name": "uniprot", "db_id": "P01024" } ] } ]
[]
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[]
1.0alpha7.train.554
11563423
[ { "id": "1.0alpha7.train.554.sent", "type": "sentence", "text": [ "BRG1 binds to HP1alpha in vitro inding assays between BRG1 and HP1alpha were performed in vitro." ], "offsets": [ [ 0, 102 ] ] } ]
[ { "id": "1.0alpha7.train.554.ent0_0", "type": "protein", "text": [ "BRG1" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6597" }, { "db_name": "hgnc", "db_id": "SMARCA4" }, { "db_name": "uniprot", "db_id": "P51532" } ] }, { "id": "1.0alpha7.train.554.ent1_1", "type": "protein", "text": [ "BRG1" ], "offsets": [ [ 58, 62 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6597" }, { "db_name": "hgnc", "db_id": "SMARCA4" }, { "db_name": "uniprot", "db_id": "P51532" } ] }, { "id": "1.0alpha7.train.554.ent2_0", "type": "protein", "text": [ "HP1alpha" ], "offsets": [ [ 15, 23 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23468" }, { "db_name": "hgnc", "db_id": "CBX5" }, { "db_name": "uniprot", "db_id": "P45973" } ] }, { "id": "1.0alpha7.train.554.ent3_1", "type": "protein", "text": [ "HP1alpha" ], "offsets": [ [ 68, 76 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23468" }, { "db_name": "hgnc", "db_id": "CBX5" }, { "db_name": "uniprot", "db_id": "P45973" } ] } ]
[]
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1.0alpha7.train.555
9738434
[ { "id": "1.0alpha7.train.555.sent", "type": "sentence", "text": [ "Crk Binding to CAS Is Required for the Induction of Cell Migration" ], "offsets": [ [ 0, 66 ] ] } ]
[ { "id": "1.0alpha7.train.555.ent0_0", "type": "protein-family", "text": [ "CAS" ], "offsets": [ [ 15, 18 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR037362" } ] }, { "id": "1.0alpha7.train.555.ent1_0", "type": "protein", "text": [ "Crk" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1398" }, { "db_name": "hgnc", "db_id": "CRK" }, { "db_name": "uniprot", "db_id": "P46108" } ] } ]
[]
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1.0alpha7.train.556
23202160
[ { "id": "1.0alpha7.train.556.sent", "type": "sentence", "text": [ "In support of these results, biochemical studies have shown that both STNA and STNB bind to the C2B domain of Syt, STNB through its region of homology with AP50 and STNA through its N terminal 250 residues (L. Kelly, personal communication) (Stimson et al., 1998). " ], "offsets": [ [ 0, 265 ] ] } ]
[ { "id": "1.0alpha7.train.556.ent0_0", "type": "protein-domain", "text": [ "C2B" ], "offsets": [ [ 96, 99 ] ], "normalized": [] }, { "id": "1.0alpha7.train.556.ent1_0", "type": "protein", "text": [ "AP50" ], "offsets": [ [ 156, 160 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1173" }, { "db_name": "hgnc", "db_id": "AP2M1" }, { "db_name": "uniprot", "db_id": "Q96CW1" } ] }, { "id": "1.0alpha7.train.556.ent2_0", "type": "protein", "text": [ "STNB" ], "offsets": [ [ 79, 83 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q24212" } ] }, { "id": "1.0alpha7.train.556.ent3_1", "type": "protein", "text": [ "STNB" ], "offsets": [ [ 115, 119 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q24212" } ] }, { "id": "1.0alpha7.train.556.ent4_0", "type": "protein", "text": [ "STNA" ], "offsets": [ [ 70, 74 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q24211" } ] }, { "id": "1.0alpha7.train.556.ent5_1", "type": "protein", "text": [ "STNA" ], "offsets": [ [ 165, 169 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q24211" } ] }, { "id": "1.0alpha7.train.556.ent6_0", "type": "protein", "text": [ "Syt" ], "offsets": [ [ 110, 113 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6760" }, { "db_name": "hgnc", "db_id": "SS18" }, { "db_name": "uniprot", "db_id": "Q15532" } ] } ]
[]
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1.0alpha7.train.557
16222433
[ { "id": "1.0alpha7.train.557.sent", "type": "sentence", "text": [ " Interaction between Eps15 and the EGF receptor has not been detected, but Eps15 does bind AP2. " ], "offsets": [ [ 0, 101 ] ] } ]
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[]
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1.0alpha7.train.558
15783736
[ { "id": "1.0alpha7.train.558.sent", "type": "sentence", "text": [ "Phosphorylation events are important for the regulation of Sp1 binding to the NRE site." ], "offsets": [ [ 0, 89 ] ] } ]
[ { "id": "1.0alpha7.train.558.ent0_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 60, 63 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.558.ent1_0", "type": "DNA", "text": [ "NRE site" ], "offsets": [ [ 80, 88 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.559
11989550
[ { "id": "1.0alpha7.train.559.sent", "type": "sentence", "text": [ " Binding of PIP2 to vinculin unfolds the inactive molecule and exposes binding sites for talin and alpha-actinin in the head domain and for VASP in the tail domain ( Gilmore and Burridge, 1996; Huttelmaier et al., 1999). " ], "offsets": [ [ 0, 230 ] ] } ]
[ { "id": "1.0alpha7.train.559.ent0_0", "type": "protein", "text": [ "vinculin" ], "offsets": [ [ 22, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7414" }, { "db_name": "hgnc", "db_id": "VCL" }, { "db_name": "uniprot", "db_id": "P18206" } ] }, { "id": "1.0alpha7.train.559.ent1_0", "type": "protein-family", "text": [ "alpha-actinin" ], "offsets": [ [ 103, 116 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR026921" } ] }, { "id": "1.0alpha7.train.559.ent2_0", "type": "protein", "text": [ "talin" ], "offsets": [ [ 92, 97 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7094" }, { "db_name": "hgnc", "db_id": "TLN1" }, { "db_name": "uniprot", "db_id": "Q9Y490" } ] }, { "id": "1.0alpha7.train.559.ent3_0", "type": "protein", "text": [ "VASP" ], "offsets": [ [ 145, 149 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7408" }, { "db_name": "hgnc", "db_id": "VASP" }, { "db_name": "uniprot", "db_id": "P50552" } ] }, { "id": "1.0alpha7.train.559.ent4_0", "type": "chemical", "text": [ "PIP2" ], "offsets": [ [ 13, 17 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "53480243" } ] } ]
[]
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1.0alpha7.train.560
9396424
[ { "id": "1.0alpha7.train.560.sent", "type": "sentence", "text": [ " Myopodin ( Fig. 6, a and b) and synaptopodin (unpublished data) directly bind to actin. " ], "offsets": [ [ 0, 96 ] ] } ]
[ { "id": "1.0alpha7.train.560.ent0_0", "type": "protein", "text": [ "synaptopodin" ], "offsets": [ [ 38, 50 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "11346" }, { "db_name": "hgnc", "db_id": "SYNPO" }, { "db_name": "uniprot", "db_id": "Q8N3V7" } ] }, { "id": "1.0alpha7.train.560.ent1_0", "type": "protein", "text": [ "Myopodin" ], "offsets": [ [ 5, 13 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "171024" }, { "db_name": "hgnc", "db_id": "SYNPO2" }, { "db_name": "uniprot", "db_id": "Q9UMS6" } ] }, { "id": "1.0alpha7.train.560.ent2_0", "type": "protein", "text": [ "actin" ], "offsets": [ [ 88, 93 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "58" }, { "db_name": "hgnc", "db_id": "ACTA1" }, { "db_name": "uniprot", "db_id": "P68133" } ] } ]
[]
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1.0alpha7.train.561
1124651
[ { "id": "1.0alpha7.train.561.sent", "type": "sentence", "text": [ "Although HOXD4 showed stable binding to T6 in our hands (Table I), poor T6 binding was reported for its paralog, HOXB4. " ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "1.0alpha7.train.561.ent0_0", "type": "protein", "text": [ "HOXD4" ], "offsets": [ [ 9, 14 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3233" }, { "db_name": "hgnc", "db_id": "HOXD4" }, { "db_name": "uniprot", "db_id": "P09016" } ] }, { "id": "1.0alpha7.train.561.ent1_0", "type": "protein", "text": [ "T6" ], "offsets": [ [ 40, 42 ] ], "normalized": [] }, { "id": "1.0alpha7.train.561.ent2_1", "type": "protein", "text": [ "T6" ], "offsets": [ [ 72, 74 ] ], "normalized": [] }, { "id": "1.0alpha7.train.561.ent3_0", "type": "protein", "text": [ "HOXB4" ], "offsets": [ [ 113, 118 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3214" }, { "db_name": "hgnc", "db_id": "HOXB4" }, { "db_name": "uniprot", "db_id": "P17483" } ] } ]
[]
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1.0alpha7.train.562
11757488
[ { "id": "1.0alpha7.train.562.sent", "type": "sentence", "text": [ "Bandshift experiments showed that a fraction of complexes containing cyclin E, cdk2 and p130 were bound to E2F proteins in serum-starved p27-/- MycER cells, whereas no cyclin E-cdk2-p130-E2F complexes were detectable in serum-starved p27+/+ MycER cells (not shown)." ], "offsets": [ [ 0, 265 ] ] } ]
[ { "id": "1.0alpha7.train.562.ent0_0", "type": "protein-family", "text": [ "cyclin E" ], "offsets": [ [ 69, 77 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR028858" } ] }, { "id": "1.0alpha7.train.562.ent1_1", "type": "protein-family", "text": [ "cyclin E" ], "offsets": [ [ 168, 176 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR028858" } ] }, { "id": "1.0alpha7.train.562.ent2_0", "type": "protein-family", "text": [ "E2F proteins" ], "offsets": [ [ 107, 119 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR015633" } ] }, { "id": "1.0alpha7.train.562.ent3_0", "type": "protein", "text": [ "p130" ], "offsets": [ [ 88, 92 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5934" }, { "db_name": "hgnc", "db_id": "RBL2" }, { "db_name": "uniprot", "db_id": "Q08999" } ] }, { "id": "1.0alpha7.train.562.ent4_1", "type": "protein", "text": [ "p130" ], "offsets": [ [ 182, 186 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5934" }, { "db_name": "hgnc", "db_id": "RBL2" }, { "db_name": "uniprot", "db_id": "Q08999" } ] }, { "id": "1.0alpha7.train.562.ent5_0", "type": "protein-complex", "text": [ "cyclin E-cdk2-p130-E2F" ], "offsets": [ [ 168, 190 ] ], "normalized": [] }, { "id": "1.0alpha7.train.562.ent6_0", "type": "protein-family", "text": [ "E2F" ], "offsets": [ [ 107, 110 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR015633" } ] }, { "id": "1.0alpha7.train.562.ent7_1", "type": "protein-family", "text": [ "E2F" ], "offsets": [ [ 187, 190 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR015633" } ] }, { "id": "1.0alpha7.train.562.ent8_0", "type": "protein", "text": [ "cdk2" ], "offsets": [ [ 79, 83 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1017" }, { "db_name": "hgnc", "db_id": "CDK2" }, { "db_name": "uniprot", "db_id": "P24941" } ] }, { "id": "1.0alpha7.train.562.ent9_1", "type": "protein", "text": [ "cdk2" ], "offsets": [ [ 177, 181 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1017" }, { "db_name": "hgnc", "db_id": "CDK2" }, { "db_name": "uniprot", "db_id": "P24941" } ] }, { "id": "1.0alpha7.train.562.ent10_0", "type": "cell", "text": [ "MycER" ], "offsets": [ [ 144, 149 ] ], "normalized": [] }, { "id": "1.0alpha7.train.562.ent11_1", "type": "cell", "text": [ "MycER" ], "offsets": [ [ 241, 246 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.563
19615854
[ { "id": "1.0alpha7.train.563.sent", "type": "sentence", "text": [ " In addition, it has been proposed that TOY and EY diverged to regulate different sets of target genes because of a N14G mutation that changes the DNA binding specificity of the PD domain of ey (Czerny et al., 1999 ). " ], "offsets": [ [ 0, 226 ] ] } ]
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[]
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1.0alpha7.train.564
24542475
[ { "id": "1.0alpha7.train.564.sent", "type": "sentence", "text": [ " Since Smad2 and Smad4 synergize with FAST2 to induce the gsc promoter, we sought to determine whether FAST2 binds directly to the gsc element and whether it supports formation of a DNA-binding complex with Smads. " ], "offsets": [ [ 0, 223 ] ] } ]
[ { "id": "1.0alpha7.train.564.ent0_0", "type": "DNA", "text": [ "gsc promoter" ], "offsets": [ [ 63, 75 ] ], "normalized": [] }, { "id": "1.0alpha7.train.564.ent1_0", "type": "DNA", "text": [ "gsc element" ], "offsets": [ [ 139, 150 ] ], "normalized": [] }, { "id": "1.0alpha7.train.564.ent2_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 190, 193 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.564.ent3_0", "type": "protein", "text": [ "Smad4" ], "offsets": [ [ 19, 24 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4089" }, { "db_name": "hgnc", "db_id": "SMAD4" }, { "db_name": "uniprot", "db_id": "Q13485" } ] }, { "id": "1.0alpha7.train.564.ent4_0", "type": "protein", "text": [ "FAST2" ], "offsets": [ [ 41, 46 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8928" }, { "db_name": "hgnc", "db_id": "FOXH1" }, { "db_name": "uniprot", "db_id": "O75593" } ] }, { "id": "1.0alpha7.train.564.ent5_1", "type": "protein", "text": [ "FAST2" ], "offsets": [ [ 109, 114 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8928" }, { "db_name": "hgnc", "db_id": "FOXH1" }, { "db_name": "uniprot", "db_id": "O75593" } ] }, { "id": "1.0alpha7.train.564.ent6_0", "type": "protein", "text": [ "Smad2" ], "offsets": [ [ 8, 13 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4087" }, { "db_name": "hgnc", "db_id": "SMAD2" }, { "db_name": "uniprot", "db_id": "Q15796" } ] }, { "id": "1.0alpha7.train.564.ent7_0", "type": "protein-family", "text": [ "Smads" ], "offsets": [ [ 215, 220 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR017855" } ] } ]
[]
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1.0alpha7.train.565
6619861
[ { "id": "1.0alpha7.train.565.sent", "type": "sentence", "text": [ "On the basis of averaging the results of three to five independent experiments in each case, the concentration of competitor required to reduce binding of BLM to the X-junction DNA to 50% of control values was as follows." ], "offsets": [ [ 0, 221 ] ] } ]
[ { "id": "1.0alpha7.train.565.ent0_0", "type": "protein", "text": [ "BLM" ], "offsets": [ [ 155, 158 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "641" }, { "db_name": "hgnc", "db_id": "BLM" }, { "db_name": "uniprot", "db_id": "P54132" } ] }, { "id": "1.0alpha7.train.565.ent1_0", "type": "DNA", "text": [ "X-junction DNA" ], "offsets": [ [ 166, 180 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.566
16027275
[ { "id": "1.0alpha7.train.566.sent", "type": "sentence", "text": [ "A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74." ], "offsets": [ [ 0, 158 ] ] } ]
[ { "id": "1.0alpha7.train.566.ent0_0", "type": "protein", "text": [ "Elf1" ], "offsets": [ [ 144, 148 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1997" }, { "db_name": "hgnc", "db_id": "ELF1" }, { "db_name": "uniprot", "db_id": "P32519" } ] }, { "id": "1.0alpha7.train.566.ent1_0", "type": "protein-domain", "text": [ "Ets" ], "offsets": [ [ 41, 44 ] ], "normalized": [] }, { "id": "1.0alpha7.train.566.ent2_0", "type": "protein", "text": [ "Ets1" ], "offsets": [ [ 93, 97 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2113" }, { "db_name": "hgnc", "db_id": "ETS1" }, { "db_name": "uniprot", "db_id": "P14921" } ] }, { "id": "1.0alpha7.train.566.ent3_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 65, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.566.ent4_0", "type": "protein", "text": [ "E74" ], "offsets": [ [ 154, 157 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P11536" } ] } ]
[]
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1.0alpha7.train.567
4241455
[ { "id": "1.0alpha7.train.567.sent", "type": "sentence", "text": [ "Binding of in vitro synthesized HOX and PBX1b to the PPE." ], "offsets": [ [ 0, 62 ] ] } ]
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[]
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1.0alpha7.train.568
2892411
[ { "id": "1.0alpha7.train.568.sent", "type": "sentence", "text": [ " GST-GR does not bind the purified TPR domain fragment of PP5, and the PP5 TPR domain does not compete for the binding of FKBP52 to GST-GR (data not shown) under conditions in which it blocks FKBP52 binding to hsp90 ( 33). " ], "offsets": [ [ 0, 231 ] ] } ]
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[]
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1.0alpha7.train.569
4810865
[ { "id": "1.0alpha7.train.569.sent", "type": "sentence", "text": [ "Characterization the nuclear proteins that bind to the PRE site of the aurora A gene." ], "offsets": [ [ 0, 89 ] ] } ]
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[]
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[]
1.0alpha7.train.570
589672
[ { "id": "1.0alpha7.train.570.sent", "type": "sentence", "text": [ " This sequence shares similarity with the RII binding regions of AKAP 150, Ht 31, and MAP 2 (14, 32, 34, 35) . " ], "offsets": [ [ 0, 120 ] ] } ]
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[]
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1.0alpha7.train.571
12497496
[ { "id": "1.0alpha7.train.571.sent", "type": "sentence", "text": [ "The histone deacetylase activity of Sir2 is required for stable binding of Sir2 and Sir3 at 70 bp (Fig. 2)." ], "offsets": [ [ 0, 113 ] ] } ]
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[]
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1.0alpha7.train.572
1932390
[ { "id": "1.0alpha7.train.572.sent", "type": "sentence", "text": [ " However, because binding of TPR proteins to the TPR binding site on hsp90 is a reversible process, over time, a single receptor. " ], "offsets": [ [ 0, 134 ] ] } ]
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[]
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1.0alpha7.train.573
15811317
[ { "id": "1.0alpha7.train.573.sent", "type": "sentence", "text": [ "We then compared binding of PAX4 and PAX6 to the same oligonucleotide probes." ], "offsets": [ [ 0, 79 ] ] } ]
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[]
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[]
1.0alpha7.train.574
19301544
[ { "id": "1.0alpha7.train.574.sent", "type": "sentence", "text": [ " Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active. " ], "offsets": [ [ 0, 108 ] ] } ]
[ { "id": "1.0alpha7.train.574.ent0_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 73, 76 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.574.ent1_0", "type": "protein-family", "text": [ "GTPase" ], "offsets": [ [ 19, 25 ] ], "normalized": [] }, { "id": "1.0alpha7.train.574.ent2_0", "type": "protein-family", "text": [ "Ras" ], "offsets": [ [ 39, 42 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039360" } ] }, { "id": "1.0alpha7.train.574.ent3_1", "type": "protein-family", "text": [ "Ras" ], "offsets": [ [ 92, 95 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039360" } ] }, { "id": "1.0alpha7.train.574.ent4_0", "type": "protein", "text": [ "GTP-bound form of Ras" ], "offsets": [ [ 73, 95 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.575
24702406
[ { "id": "1.0alpha7.train.575.sent", "type": "sentence", "text": [ "[In new window] We next tested whether the upstream CU elements affected PTB binding to the downstream CU elements." ], "offsets": [ [ 0, 118 ] ] } ]
[ { "id": "1.0alpha7.train.575.ent0_0", "type": "DNA", "text": [ "CU elements" ], "offsets": [ [ 53, 64 ] ], "normalized": [] }, { "id": "1.0alpha7.train.575.ent1_1", "type": "DNA", "text": [ "CU elements" ], "offsets": [ [ 106, 117 ] ], "normalized": [] }, { "id": "1.0alpha7.train.575.ent2_0", "type": "protein", "text": [ "PTB" ], "offsets": [ [ 75, 78 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5725" }, { "db_name": "hgnc", "db_id": "PTBP1" }, { "db_name": "uniprot", "db_id": "P26599" } ] } ]
[]
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