ads_id
stringlengths 8
8
| arxiv_id
int64 0
999
| title
stringlengths 0
236
| abstract
stringlengths 0
4.26k
⌀ | embed
sequencelengths 1.54k
1.54k
| date
date32 | cites
int64 1
1.16k
| bibcode
stringlengths 8
8
| keywords
sequencelengths 0
30
| ads_keywords
sequencelengths 0
14
| read_count
int64 0
0
| doi
stringlengths 13
16.8k
⌀ | authors
sequencelengths 0
66
| aff
sequencelengths 0
66
| cite_bibcodes
sequencelengths 1
1.16k
| ref_bibcodes
sequencelengths 0
0
| umap_x
float32 4.76
33.7
| umap_y
float32 2.73
7.65
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
39042728 | 700 | Generation of antitumor chimeric antigen receptors incorporating T cell signaling motifs. | Chimeric antigen receptor (CAR) T cells have been used to successfully treat various blood cancers, but adverse effects have limited their potential. Here, we developed chimeric adaptor proteins (CAPs) and CAR tyrosine kinases (CAR-TKs) in which the intracellular ζ T cell receptor (TCRζ) chain was replaced with intracellular protein domains to stimulate signaling downstream of the TCRζ chain. CAPs contain adaptor domains and the kinase domain of ZAP70, whereas CAR-TKs contain only ZAP70 domains. We hypothesized that CAPs and CAR-TKs would be more potent than CARs because they would bypass both the steps that define the signaling threshold of TCRζ and the inhibitory regulation of upstream molecules. CAPs were too potent and exhibited high tonic signaling in vitro. In contrast, CAR-TKs exhibited high antitumor efficacy and significantly enhanced long-term tumor clearance in leukemia-bearing NSG mice as compared with the conventional CD19-28ζ-CAR-T cells. CAR-TKs were activated in a manner independent of the kinase Lck and displayed slower phosphorylation kinetics and prolonged signaling compared with the 28ζ-CAR. Lck inhibition attenuated CAR-TK cell exhaustion and improved long-term function. The distinct signaling properties of CAR-TKs may therefore be harnessed to improve the in vivo efficacy of T cells engineered to express an antitumor chimeric receptor. | [
0.0385613776743412,
0.02286805957555771,
-0.0032428684644401073,
0.05471023917198181,
-0.01955401338636875,
-0.0054693156853318214,
-0.025510186329483986,
-0.0025908781681209803,
0.0023816151078790426,
-0.014770853333175182,
0.004057144746184349,
-0.004188111983239651,
-0.02917727455496788,
0.008729266934096813,
0.009987693279981613,
-0.05830899626016617,
0.03487151488661766,
-0.008176925592124462,
0.013928106054663658,
0.018882092088460922,
0.01609191671013832,
-0.0024228983093053102,
-0.005349736660718918,
0.010283793322741985,
-0.032001618295907974,
0.00788082554936409,
0.029268382117152214,
0.005272864364087582,
-0.028630629181861877,
-0.018529050052165985,
0.041659045964479446,
-0.016285520046949387,
-0.056532394140958786,
-0.02503187023103237,
0.007089326158165932,
0.02475854568183422,
0.010147131979465485,
0.013734501786530018,
-0.0215242188423872,
-0.05521133169531822,
0.0259885024279356,
0.03901691734790802,
0.010938631370663643,
0.0721118301153183,
-0.0671008974313736,
-0.012060396373271942,
-0.01737881451845169,
-0.004805936943739653,
0.006013115402311087,
0.015135284513235092,
0.00863815937191248,
0.028152313083410263,
-0.020863687619566917,
0.03860693424940109,
-0.05047372356057167,
0.027309564873576164,
-0.00989658571779728,
-0.01389394048601389,
0.001742436783388257,
0.036078691482543945,
0.009811172261834145,
-0.005090648774057627,
0.014907514676451683,
0.0029268383514136076,
-0.060723353177309036,
-0.0034734851215034723,
-0.058764535933732986,
-0.015898311510682106,
0.0007495040772482753,
0.06600760668516159,
0.011405558325350285,
-0.016467735171318054,
0.002847119001671672,
0.018870703876018524,
0.028266197070479393,
-0.011360004544258118,
0.004122628364712,
0.04810492321848869,
0.04628276452422142,
0.015841370448470116,
0.04204625263810158,
0.000040349015762330964,
0.006952664349228144,
-0.035919252783060074,
-0.006531290709972382,
-0.023893022909760475,
-0.01349534373730421,
-0.05484690144658089,
-0.004498447757214308,
-0.0074480632320046425,
0.0021339156664907932,
0.04159071296453476,
-0.06177109479904175,
0.021045902743935585,
-0.013973659835755825,
0.04270678386092186,
-0.04400506988167763,
-0.040542975068092346,
0.03209272399544716,
0.03541816025972366,
0.06454987823963165,
-0.008182619698345661,
-0.04783159866929054,
0.004162488039582968,
0.0234830379486084,
0.039153579622507095,
-0.06773865222930908,
0.0028884022030979395,
0.015454161912202835,
0.005796734243631363,
0.09757646173238754,
-0.027696773409843445,
-0.03254826366901398,
0.056987933814525604,
-0.013347293250262737,
-0.09757646173238754,
-0.042501792311668396,
-0.0120148416608572,
-0.011502360925078392,
0.02018037997186184,
-0.000608215807005763,
0.04127183556556702,
0.0452578030526638,
-0.01855182647705078,
-0.00931007880717516,
0.0036300767678767443,
0.05079260095953941,
0.01023254543542862,
-0.027036242187023163,
-0.042843446135520935,
0.009828254580497742,
0.0013915293384343386,
0.0005356142646633089,
0.016388017684221268,
-0.04168182238936424,
-0.019827336072921753,
-0.013734501786530018,
-0.02242390811443329,
-0.04566778987646103,
0.005961867049336433,
0.0060586691834032536,
-0.022480851039290428,
0.0142583716660738,
-0.011217649094760418,
-0.04509836435317993,
-0.03885747864842415,
0.004737605806440115,
0.018517661839723587,
-0.03291269391775131,
0.03414265066385269,
-0.026011278852820396,
0.05448246747255325,
0.055530209094285965,
-0.03562315180897713,
0.013108136132359505,
-0.052796974778175354,
-0.022902224212884903,
0.0380147323012352,
-0.031158870086073875,
-0.04874267801642418,
-0.01059128250926733,
0.00732279010117054,
-0.02790176495909691,
0.021034514531493187,
0.005412373226135969,
-0.019257912412285805,
-0.010409067384898663,
0.03655700758099556,
-0.06391212344169617,
-0.00007366920181084424,
-0.022287247702479362,
-0.04017854109406471,
-0.06104223057627678,
-0.021045902743935585,
-0.042570121586322784,
-0.014133098535239697,
-0.0025737956166267395,
0.044073402881622314,
-0.040155764669179916,
-0.033277127891778946,
0.002949615241959691,
0.009367021732032299,
0.03603313863277435,
0.00931007880717516,
-0.018210172653198242,
0.018631545826792717,
-0.03232049569487572,
0.02268584445118904,
-0.03509928286075592,
-0.0396774485707283,
0.0156591534614563,
0.013062581419944763,
0.04093018174171448,
0.016444958746433258,
-0.03145496919751167,
-0.017697691917419434,
0.03370988741517067,
0.025396300479769707,
0.0026122317649424076,
-0.03325434774160385,
0.008797597140073776,
-0.020487867295742035,
-0.026125162839889526,
0.016798002645373344,
-0.025920171290636063,
0.026922356337308884,
-0.008091512136161327,
0.011325838975608349,
-0.030817216262221336,
-0.0011374240275472403,
0.04398229345679283,
-0.01078488677740097,
-0.011935122311115265,
0.005349736660718918,
-0.0251457542181015,
-0.02364247664809227,
0.0014150181086733937,
0.04482503980398178,
-0.016684116795659065,
-0.002626467263326049,
-0.024211900308728218,
0.0016897651366889477,
-0.019975386559963226,
-0.033345457166433334,
-0.0788082554936409,
-0.004589555785059929,
-0.0031232894398272038,
-0.008376223966479301,
0.014167264103889465,
0.009389798156917095,
-0.02783343568444252,
0.02571517787873745,
0.04405062645673752,
-0.03612424433231354,
-0.035964805632829666,
-0.014987234026193619,
0.0447111576795578,
0.0051504382863640785,
0.0698796883225441,
-0.021455887705087662,
0.007396814879029989,
0.0299061369150877,
0.015499715693295002,
-0.02810675837099552,
-0.04332176223397255,
-0.016422182321548462,
0.0007665868033654988,
-0.06559762358665466,
-0.02503187023103237,
-0.015192226506769657,
0.026899579912424088,
0.0025695248041301966,
-0.013734501786530018,
0.019246524199843407,
0.02503187023103237,
0.03678477555513382,
0.046920519322156906,
-0.00768722128123045,
0.01766352541744709,
-0.007539170794188976,
0.025624070316553116,
0.011547914706170559,
-0.021159788593649864,
-0.02582906372845173,
-0.03359600529074669,
0.02391579933464527,
0.026740141212940216,
0.01207178458571434,
0.011616244912147522,
0.0019588179420679808,
0.058718983083963394,
0.011200565844774246,
0.03537260740995407,
-0.0053070299327373505,
-0.07807938754558563,
0.021421723067760468,
0.006901416461914778,
0.018642935901880264,
0.00180649699177593,
0.024553554132580757,
-0.000014024285519553814,
0.012356496416032314,
0.013597840443253517,
-0.018904870375990868,
-0.021000349894165993,
-0.012777869589626789,
0.009258830919861794,
-0.003533274633809924,
0.020191768184304237,
0.003063499927520752,
0.02229863591492176,
-0.005859370809048414,
-0.027856212109327316,
-0.016410794109106064,
-0.02285667136311531,
0.036534231156110764,
-0.0357598140835762,
-0.017754632979631424,
-0.05225032567977905,
-0.02269723266363144,
-0.029200052842497826,
0.03370988741517067,
-0.015829982236027718,
-0.04856046289205551,
0.016524678096175194,
0.005537646356970072,
0.02967836894094944,
-0.053070299327373505,
0.018176008015871048,
0.04090740531682968,
0.021763376891613007,
-0.022879447788000107,
0.028767289593815804,
0.0018477801932021976,
0.0047404528595507145,
-0.024052461609244347,
0.011866792105138302,
-0.0631377100944519,
0.04293455556035042,
-0.03951800987124443,
-0.047148291021585464,
-0.006149776745587587,
-0.03849304839968681,
-0.00931007880717516,
0.038538601249456406,
-0.011331533081829548,
-0.00006156894960440695,
-0.009537848643958569,
0.016285520046949387,
-0.02224169299006462,
0.03995077311992645,
-0.035190388560295105,
0.067055344581604,
-0.03951800987124443,
-0.005443691276013851,
-0.018585992977023125,
-0.029883360490202904,
-0.034461528062820435,
0.0004103410174138844,
0.02398413047194481,
-0.016183024272322655,
0.0491982139647007,
-0.043071214109659195,
0.07352399826049805,
-0.00550632830709219,
-0.0016940358327701688,
0.03605591505765915,
0.007977627217769623,
0.006918499246239662,
0.018426554277539253,
-0.01592108979821205,
0.013108136132359505,
0.035577598959207535,
-0.009008284658193588,
0.010807663202285767,
0.053571391850709915,
-0.04086185246706009,
-0.012060396373271942,
-0.006024503614753485,
0.00916772335767746,
0.017424367368221283,
0.029997246339917183,
-0.04108962044119835,
0.010044635273516178,
0.04500725492835045,
0.0637299120426178,
-0.0307488851249218,
0.022663066163659096,
-0.028266197070479393,
-0.009258830919861794,
0.004837254993617535,
-0.022013923153281212,
0.011240425519645214,
0.043002884835004807,
0.0015203615184873343,
0.005893536377698183,
0.039882443845272064,
0.03136386349797249,
0.04769493639469147,
-0.01170735340565443,
0.018597381189465523,
-0.04354953020811081,
0.009406881406903267,
-0.013256185688078403,
0.03113609366118908,
0.00765874981880188,
0.03751363977789879,
-0.014884738251566887,
-0.07297735661268234,
0.04783159866929054,
-0.006343381013721228,
-0.016080528497695923,
0.0034535552840679884,
-0.02806120365858078,
-0.00989089161157608,
0.06523319333791733,
0.01811906509101391,
0.083819180727005,
0.05174923315644264,
0.029359491541981697,
-0.03509928286075592,
-0.024325784295797348,
-0.02252640575170517,
-0.035691484808921814,
0.025532962754368782,
-0.027696773409843445,
0.020214544609189034,
0.003185926005244255,
0.025305192917585373,
-0.014395033940672874,
0.047376058995723724,
0.016023585572838783,
0.03259381651878357,
-0.013290351256728172,
0.029086166992783546,
-0.024211900308728218,
-0.009771312586963177,
0.020886464044451714,
-0.019497070461511612,
0.034962620586156845,
0.021660881116986275,
-0.057261258363723755,
-0.011775683611631393,
-0.0018734042532742023,
0.00009822560241445899,
-0.001545985578559339,
0.031158870086073875,
-0.013142300769686699,
0.018904870375990868,
-0.03113609366118908,
0.00021869433112442493,
0.036966994404792786,
0.006445877254009247,
-0.03598758205771446,
-0.003675630548968911,
0.044961702078580856,
-0.020556198433041573,
0.02767399698495865,
-0.061679985374212265,
0.023505814373493195,
-0.03309490904211998,
-0.0153744425624609,
0.03140941634774208,
-0.01990705542266369,
0.02644404023885727,
-0.02202531322836876,
-0.009925056248903275,
-0.016741059720516205,
-0.02956448309123516,
0.0067135063000023365,
-0.033573225140571594,
0.010175603441894054,
-0.0318421795964241,
0.020248709246516228,
-0.05338917300105095,
-0.002101173857226968,
0.040497418493032455,
-0.03990522027015686,
0.005238698795437813,
0.025009093806147575,
0.0357598140835762,
-0.044027846306562424,
0.016399405896663666,
-0.03673922270536423,
0.006747671868652105,
0.041841261088848114,
0.03170551732182503,
-0.018244339153170586,
0.021763376891613007,
-0.008900093846023083,
-0.004495600704103708,
0.010893077589571476,
-0.025282416492700577,
0.036306459456682205,
-0.006229496095329523,
0.05051928013563156,
0.037263091653585434,
0.00574263883754611,
0.02683124877512455,
0.01839238777756691,
-0.028812844306230545,
-0.025783509016036987,
-0.02359692193567753,
0.024394115433096886,
0.010579894296824932,
0.04127183556556702,
0.01610330492258072,
0.009412575513124466,
-0.01799379102885723,
0.034962620586156845,
0.004501295275986195,
-0.012846200726926327,
0.034734852612018585,
-0.009663121774792671,
0.010038941167294979,
0.00989089161157608,
0.013483955524861813,
0.019713452085852623,
-0.02380191534757614,
-0.0020057952497154474,
0.006696423981338739,
0.0013637699885293841,
0.00947521161288023,
0.02068147249519825,
0.013757279142737389,
0.07817050069570541,
0.03179662302136421,
0.05858232080936432,
0.006411711685359478,
0.03598758205771446,
-0.03664811700582504,
-0.0391080267727375,
0.05334362015128136,
-0.0033396705985069275,
-0.044073402881622314,
-0.025350747630000114,
-0.07388842850923538,
-0.01445197593420744,
-0.007499311584979296,
-0.007926379330456257,
-0.03257104009389877,
-0.010631142184138298,
-0.02106868103146553,
0.009395492263138294,
-0.007379732560366392,
-0.012231223285198212,
-0.03416542708873749,
-0.04427839443087578,
-0.03621535375714302,
-0.024166345596313477,
0.045531127601861954,
-0.010095884092152119,
0.03156885504722595,
0.010283793322741985,
-0.005432303063571453,
-0.012766481377184391,
-0.038037508726119995,
0.0525236502289772,
-0.012880366295576096,
-0.051840342581272125,
-0.004210888873785734,
-0.021114233881235123,
0.01389394048601389,
-0.03259381651878357,
0.00501662353053689,
0.005984643939882517,
0.006451571360230446,
-0.04915266111493111,
0.013347293250262737,
-0.006081446073949337,
0.0363292396068573,
-0.02437133900821209,
0.0029239910654723644,
-0.03168274089694023,
0.009680204093456268,
-0.03878914937376976,
-0.015283335000276566,
-0.01095571368932724,
-0.011980677023530006,
-0.05161257088184357,
-0.03159163147211075,
-0.000854135665576905,
-0.0019602414686232805,
-0.03318601846694946,
-0.019292078912258148,
-0.0017652137903496623,
-0.018654324114322662,
0.007715692277997732,
-0.051293693482875824,
0.04493892565369606,
0.0010954290628433228,
-0.011798460967838764,
0.008011792786419392,
-0.007112103048712015,
0.03678477555513382,
0.003573134308680892,
-0.00370979611761868,
0.0014043414266780019,
0.004934057127684355,
0.009059532545506954,
-0.05015484616160393,
0.0002509023470338434,
0.0035987584851682186,
0.04439228028059006,
-0.025282416492700577,
0.005509175360202789,
-0.029222829267382622,
-0.02717290259897709,
-0.018483497202396393,
0.019690675660967827,
0.018141841515898705,
0.0006808173493482172,
0.02571517787873745,
0.030885547399520874,
-0.05138480290770531,
0.020658696070313454,
-0.005341195035725832,
-0.022093642503023148,
-0.039153579622507095,
-0.0006338398670777678,
0.007191822398453951,
0.0043589393608272076,
-0.031227201223373413,
-0.060450028628110886,
-0.04539446532726288,
0.006816003005951643,
-0.008222479373216629,
-0.007413897663354874,
-0.012060396373271942,
0.02840285934507847,
0.08067595958709717,
0.0318649560213089,
-0.0047518415376544,
0.021148400381207466,
0.012310942634940147,
0.001173724769614637,
-0.016809390857815742,
-0.010557116940617561,
0.01799379102885723,
-0.005973255727440119,
-0.03901691734790802,
-0.018585992977023125,
-0.02995169162750244,
0.0082395626232028,
-0.01495306845754385,
-0.005634448491036892,
0.009446741081774235,
0.008063040673732758,
0.01776602305471897,
0.011223343200981617,
0.005435150116682053,
-0.03375544399023056,
-0.016057750210165977,
0.0536624975502491,
-0.004777465481311083,
-0.031090538948774338,
0.02292500250041485,
-0.005460774060338736,
0.0038749289233237505,
0.0234830379486084,
-0.006787531543523073,
-0.008330670185387135,
-0.01827850379049778,
-0.03917635604739189,
0.02995169162750244,
0.010653919540345669,
-0.015237780287861824,
0.03594202920794487,
0.012185669504106045,
-0.007607501931488514,
-0.002723269397392869,
-0.016183024272322655,
0.024075238034129143,
-0.012925920076668262,
0.010363512672483921,
-0.03421097993850708,
0.010192685760557652,
-0.013381458818912506,
0.05817233398556709,
0.07625723630189896,
-0.02699068747460842,
0.013028416782617569,
0.0051760622300207615,
-0.013643394224345684,
-0.017287706956267357,
-0.007863742299377918,
0.02135339193046093,
0.00028097504400648177,
0.0024214747827500105,
0.008376223966479301,
0.08108595013618469,
0.014201429672539234,
-0.015795815736055374,
-0.0009246018598787487,
0.002420051023364067,
0.024735769256949425,
-0.003140372224152088,
-0.0248724315315485,
-0.042114581912755966,
0.0027545876801013947,
0.012675373815000057,
0.010500174947082996,
-0.03610146790742874,
-0.04282066971063614,
0.015681931748986244,
-0.01961095631122589,
0.0025339359417557716,
0.03268492594361305,
0.012174280360341072,
-0.01134861633181572,
-0.03919913247227669,
0.016558844596147537,
-0.03329990431666374,
0.014235595241189003,
0.01333590503782034,
0.0014249830273911357,
-0.0016798002179712057,
-0.011229037307202816,
-0.006269355770200491,
0.005634448491036892,
0.010739332996308804,
0.01478224154561758,
0.00041354403947480023,
-0.017481310293078423,
-0.0024556401185691357,
-0.01777741126716137,
0.014292537234723568,
-0.033846549689769745,
0.014554471708834171,
0.009184805676341057,
0.003706948831677437,
0.001938887988217175,
-0.02207086607813835,
-0.016729671508073807,
-0.005252934526652098,
-0.002556712832301855,
-0.008518580347299576,
0.038811925798654556,
-0.005400984548032284,
0.019360408186912537,
-0.0204081479460001,
0.0005434438353404403,
-0.03134108707308769,
0.015021399594843388,
0.018153229728341103,
0.026580702513456345,
0.0041197813116014,
0.04366341605782509,
-0.021262284368276596,
0.0023246726486831903,
-0.005586047191172838,
-0.03790084645152092,
-0.03304935619235039,
0.008467331528663635,
-0.03339101001620293,
0.008979813195765018,
-0.0324343778192997,
-0.02721845731139183,
0.0020456549245864153,
-0.006292133126407862,
0.03393765911459923,
-0.02391579933464527,
-0.009651733562350273,
0.03644312173128128,
-0.01621718890964985,
0.010192685760557652,
0.03257104009389877,
-0.013005639426410198,
0.017071325331926346,
-0.050337065011262894,
-0.0022848129738122225,
0.006753365974873304,
0.001782296458259225,
0.0024214747827500105,
-0.009344244375824928,
-0.035235945135354996,
-0.00911647453904152,
-0.02168365754187107,
-0.017469922080636024,
-0.006275050342082977,
-0.033072132617235184,
0.017230764031410217,
-0.020943406969308853,
0.002865625312551856,
0.0012933037942275405,
-0.00045269192196428776,
0.00048329844139516354,
-0.006616704631596804,
-0.0178799070417881,
0.025191308930516243,
-0.008302198722958565,
0.0030521114822477102,
-0.0033539060968905687,
-0.010027552954852581,
-0.0013317399425432086,
0.01906430907547474,
-0.016843555495142937,
-0.004461435601115227,
0.017515476793050766,
0.017538253217935562,
-0.020544810220599174,
0.010352124460041523,
-0.015898311510682106,
0.0022848129738122225,
0.004367480520159006,
-0.037878070026636124,
0.005956172943115234,
0.002753164153546095,
-0.022116420790553093,
-0.00144206581171602,
-0.01772046834230423,
0.042000699788331985,
-0.014121710322797298,
0.024735769256949425,
0.0031916203442960978,
0.03639756888151169,
0.030657777562737465,
-0.08687129616737366,
-0.05584908649325371,
-0.011787072755396366,
-0.015271945856511593,
0.010910159908235073,
0.017139656469225883,
-0.023847468197345734,
-0.00967450998723507,
-0.0021780459210276604,
-0.022549182176589966,
0.01749269850552082,
-0.008495802991092205,
0.00692988745868206,
0.00032083471887744963,
-0.014713910408318043,
-0.023574145510792732,
-0.030361676588654518,
-0.05912896618247032,
-0.003046417376026511,
0.04143127426505089,
-0.006257967557758093,
0.020317040383815765,
-0.015522493049502373,
0.03660256043076515,
0.026193493977189064,
0.009993387386202812,
0.003638617927208543,
0.010038941167294979,
-0.04102129116654396,
0.01408754475414753,
0.03931301832199097,
-0.014269759878516197,
-0.002778788097202778,
0.03648867830634117,
-0.02521408535540104,
-0.03951800987124443,
0.023961354047060013,
-0.045303355902433395,
-0.0011068175081163645,
-0.009384104050695896,
-0.0077783288434147835,
-0.007579030469059944,
0.007744163740426302,
-0.0003818698169197887,
-0.016763836145401,
-0.013278963044285774,
-0.01720798760652542,
0.0094979889690876,
-0.0027218456380069256,
-0.011969287879765034,
0.020476479083299637,
-0.004882809240370989,
-0.004068532958626747,
0.01912125013768673,
-0.013780055567622185,
-0.004304843954741955,
0.00038898762431927025,
0.022013923153281212,
0.0038749289233237505,
0.013028416782617569,
0.0020926324650645256,
0.04719384387135506,
0.007083632051944733,
-0.02022593282163143,
0.012880366295576096,
-0.03589647635817528,
-0.0558946393430233,
0.010517257265746593,
-0.028197865933179855,
-0.009970610961318016,
-0.009315772913396358,
-0.0021182564087212086,
-0.020806744694709778,
0.027765104547142982,
-0.012299553491175175,
0.014292537234723568,
-0.012755093164741993,
0.0025140061043202877,
0.0039005528669804335,
0.017743244767189026,
-0.008171231485903263,
-0.01985011249780655,
-0.016957441344857216,
-0.03701254725456238,
-0.019200969487428665,
-0.03448430448770523,
-0.02929116040468216,
0.02119395323097706,
0.008962730877101421,
-0.0167752243578434,
-0.014554471708834171,
-0.0030976654961705208,
0.008114289492368698,
-0.005452232901006937,
-0.016615785658359528,
-0.010346430353820324,
-0.030361676588654518,
0.0048258667811751366,
-0.004196653142571449,
-0.027127349749207497,
0.029610037803649902,
-0.02872173674404621,
0.005927701480686665,
-0.05065594241023064,
-0.02867618203163147,
-0.021603938192129135,
0.03598758205771446,
0.011809849180281162,
0.02756011113524437,
-0.015636377036571503,
0.03448430448770523,
-0.010340736247599125,
0.003837916301563382,
-0.010374901816248894,
0.01318785548210144,
-0.007214599289000034,
0.02844841219484806,
-0.015943866223096848,
0.0017011535819619894,
0.0029866278637200594,
0.02856229804456234,
0.01800518110394478,
-0.0019474293803796172,
-0.026967911049723625,
-0.00045126836630515754,
0.025806285440921783,
0.015556657686829567,
0.008712183684110641,
0.03359600529074669,
0.008091512136161327,
0.02521408535540104,
-0.011468195356428623,
0.020487867295742035,
-0.027286788448691368,
-0.028357304632663727,
0.03159163147211075,
0.025054646655917168,
0.03817417100071907,
-0.00646865414455533,
0.02387024462223053,
-0.02822064235806465,
-0.014577249065041542,
0.023175548762083054,
-0.017299095168709755,
0.026762917637825012,
-0.019963998347520828,
-0.06382101774215698,
0.024690216407179832,
-0.004216582980006933,
0.006480042822659016,
-0.02833452820777893,
0.038379162549972534,
0.03364155814051628,
0.025122977793216705,
-0.02560129389166832,
-0.0007502158405259252,
0.02633015625178814,
-0.012493157759308815,
-0.01744714565575123,
0.025077423080801964,
-0.01770908012986183,
0.0419095903635025,
0.0038749289233237505,
-0.015841370448470116,
-0.000350907415850088,
-0.004333314951509237,
0.007157657295465469,
-0.00045340368524193764,
0.034575413912534714,
0.015545269474387169,
0.02917727455496788,
-0.05635017901659012,
0.034233760088682175,
0.01699160598218441,
-0.027241233736276627,
0.015864146873354912,
0.031956061720848083,
-0.026125162839889526,
-0.004615179728716612,
0.024553554132580757,
-0.02872173674404621,
-0.004361786413937807,
0.024052461609244347,
0.02828897349536419,
0.029382267966866493,
-0.019417351111769676,
0.016399405896663666,
-0.027013463899493217,
0.010636836290359497,
-0.018699876964092255,
-0.026284601539373398,
-0.02525964006781578,
-0.006064363289624453,
0.0435950867831707,
-0.004171029198914766,
-0.008615382015705109,
-0.011787072755396366,
0.01237927284091711,
-0.040155764669179916,
-0.01733325980603695,
-0.037764184176921844,
0.057489026337862015,
0.03259381651878357,
-0.03232049569487572,
-0.022093642503023148,
0.014861960895359516,
0.005361124873161316,
-0.02699068747460842,
0.024690216407179832,
0.0368758849799633,
0.030543891713023186,
0.03316324204206467,
-0.010699473321437836,
0.03544093668460846,
0.024849655106663704,
-0.011969287879765034,
0.008473025634884834,
-0.01243621576577425,
-0.042342353612184525,
-0.011832626536488533,
-0.04662441834807396,
-0.04065685719251633,
-0.004467129707336426,
-0.029610037803649902,
-0.0018734042532742023,
-0.0039375657215714455,
0.03571426123380661,
0.009577708318829536,
-0.013222020119428635,
0.02102312631905079,
-0.04097573459148407,
0.02840285934507847,
-0.00002128666346834507,
0.00860399380326271,
-0.004837254993617535,
-0.008393306285142899,
-0.0051703681237995625,
-0.019428739324212074,
0.008905787952244282,
0.009999081492424011,
0.03660256043076515,
0.020613141357898712,
0.0024129333905875683,
-0.0066565643064677715,
-0.004028673283755779,
0.00782957673072815,
0.04965375363826752,
-0.00044699767022393644,
0.022674456238746643,
0.012333719059824944,
0.005665766540914774,
0.0007943462114781141,
0.03348211944103241,
0.012447603978216648,
0.025646846741437912,
0.00048614555271342397,
0.00620671920478344,
0.017515476793050766,
0.003687018994241953,
0.022458074614405632,
-0.00785235408693552,
0.009845337830483913,
0.010050330311059952,
-0.026535149663686752,
0.020658696070313454,
0.0007680103299207985,
-0.0054750097915530205,
0.013392847962677479,
0.0029083320405334234,
0.05334362015128136,
0.006827391218394041,
0.0023403316736221313,
0.008450249210000038,
0.025555739179253578,
0.023209713399410248,
-0.010921548120677471,
0.01879098452627659,
0.010653919540345669,
-0.017242152243852615,
0.01243621576577425,
0.010579894296824932,
0.01670689322054386,
-0.025191308930516243,
-0.008393306285142899,
0.02929116040468216,
0.0021225272212177515,
-0.007801105733960867,
0.01318785548210144,
-0.022788340225815773,
-0.019440127536654472,
-0.013745889998972416,
-0.01372311357408762,
-0.010671001859009266,
-0.020670084282755852,
0.002263459609821439,
-0.02890395186841488,
-0.005326959770172834,
0.00020855145703535527,
-0.012026230804622173,
0.0035076504573225975,
-0.018460718914866447,
0.017686303704977036,
-0.011764295399188995,
-0.02940504439175129,
0.015408608131110668,
-0.02398413047194481,
-0.019155416637659073,
-0.028357304632663727,
0.05953895300626755,
-0.0024257453624159098,
-0.04475671052932739,
0.00020534844952635467,
0.018415166065096855,
-0.02387024462223053,
0.04662441834807396,
0.03541816025972366,
-0.023460259661078453,
0.0034080015029758215,
0.016729671508073807,
0.006741977762430906,
-0.034689296036958694,
0.018176008015871048,
0.030088353902101517,
-0.013540897518396378,
-0.023266656324267387,
-0.0028926727827638388,
-0.013597840443253517,
-0.016729671508073807,
0.000765874981880188,
-0.017686303704977036,
0.025737956166267395,
-0.006269355770200491,
0.008632464334368706,
-0.005520563572645187,
-0.007100714836269617,
0.007664444390684366,
-0.008723572827875614,
-0.001521785045042634,
0.0002573083620518446,
0.022366967052221298,
0.0033453647047281265,
0.010517257265746593,
0.0031773848459124565,
0.016342462971806526,
0.014987234026193619,
0.004330467898398638,
-0.005788193084299564,
-0.009156334213912487,
-0.030771661549806595,
-0.02062452957034111,
0.05042817071080208,
-0.036966994404792786,
-0.004182417877018452,
0.056532394140958786,
-0.0167752243578434,
-0.005514869466423988,
-0.00695835892111063,
0.02633015625178814,
-0.021922815591096878,
-0.01059128250926733,
-0.007977627217769623,
0.013256185688078403,
0.03808306157588959,
0.0032599512487649918,
-0.01059697661548853,
0.010551422834396362,
-0.03983688727021217,
-0.004823019728064537,
-0.005358277820050716,
0.0025709483306854963,
0.02095479518175125,
0.02023732103407383,
-0.00315176066942513,
-0.0021082914900034666,
0.007430980447679758,
0.008734961040318012,
0.03441597521305084,
0.008683713153004646,
-0.016467735171318054,
0.0259885024279356,
0.013848386704921722,
-0.017868518829345703,
-0.033573225140571594,
-0.035691484808921814,
-0.003618688089773059,
-0.013643394224345684,
-0.03432486578822136,
-0.04778604581952095,
-0.00952646043151617,
-0.037308648228645325,
-0.006548373494297266,
0.000996491638943553,
0.016183024272322655,
-0.007413897663354874,
-0.03906247392296791,
-0.015841370448470116,
0.006121305748820305,
-0.001511820126324892,
-0.002546747913584113,
-0.017845742404460907,
-0.04352675378322601,
-0.0071234917268157005,
0.01019837986677885,
-0.009105086326599121,
-0.0025851840618997812,
0.020932018756866455,
0.004088462796062231,
0.010864606127142906,
-0.0040799216367304325,
0.0030805827118456364,
-0.017481310293078423,
0.007806800305843353,
-0.0637299120426178,
-0.0035560515243560076,
-0.02767399698495865,
-0.0028898257296532393,
-0.008683713153004646,
-0.01149097178131342,
-0.021034514531493187,
-0.011935122311115265,
-0.012481769546866417,
0.022105030715465546,
-0.006440183147788048,
0.009122169576585293,
0.012868978083133698,
-0.01922374777495861,
0.005990338511765003,
0.008507191203534603,
-0.04719384387135506,
0.014338091015815735,
-0.0035588988102972507,
-0.006975441239774227,
-0.0000760714610805735,
-0.00011521934357006103,
-0.04070241376757622,
0.04760383069515228,
0.006673646625131369,
0.027878988534212112,
0.012140115723013878,
-0.004780312534421682,
-0.0024086625780910254,
-0.015306111425161362,
0.056987933814525604,
0.020430926233530045,
0.018825151026248932,
-0.006759060546755791,
0.004862879402935505,
-0.003977425396442413,
0.006001726724207401,
0.0201120488345623,
0.021205341443419456,
0.015476938337087631,
-0.029541706666350365,
-0.025965724140405655,
-0.031386639922857285,
-0.012925920076668262,
-0.03491706773638725,
-0.019576789811253548,
0.016137469559907913,
0.017800187692046165,
-0.024462446570396423,
0.02051064558327198,
-0.008273727260529995,
0.0335504487156868,
-0.004840102046728134,
-0.002051349263638258,
-0.023688029497861862,
-0.04673830419778824,
-0.01483918447047472,
-0.026694586500525475,
0.034005988389253616,
-0.0028784372843801975,
0.03849304839968681,
-0.0074423691257834435,
0.033504895865917206,
-0.019918443635106087,
0.06354769319295883,
0.014395033940672874,
-0.0034080015029758215,
-0.0011132234940305352,
-0.027856212109327316,
0.014497529715299606,
0.017014382407069206,
-0.013017027638852596,
0.02063591778278351,
0.02974669821560383,
-0.004062838852405548,
-0.004395951516926289,
0.0026563620194792747,
0.010608364827930927,
0.006633787415921688,
-0.005688543897122145,
0.006263661663979292,
-0.009469517506659031,
-0.01654745452105999,
-0.014190040528774261,
0.008649547584354877,
-0.018973201513290405,
-0.013108136132359505,
-0.01237927284091711,
-0.0060074208304286,
0.01733325980603695,
0.030839992687106133,
-0.030430007725954056,
-0.010135743767023087,
-0.023346375674009323,
-0.015226392075419426,
-0.0352131687104702,
0.01856321655213833,
0.010488785803318024,
-0.03013390675187111,
-0.011325838975608349,
-0.01990705542266369,
0.003763891290873289,
0.02498631551861763,
-0.018768208101391792,
-0.01391671784222126,
0.025851840153336525,
0.004774618428200483,
-0.0037667383439838886,
0.012105950154364109,
0.02756011113524437,
0.01860876940190792,
-0.0074423691257834435,
0.01168457604944706,
-0.03234327211976051,
0.01794823817908764,
0.04493892565369606,
-0.003763891290873289,
0.017401590943336487,
0.04760383069515228,
-0.025282416492700577,
0.005603129975497723,
-0.004692052025347948,
-0.014133098535239697,
0.05092926323413849,
-0.030839992687106133,
-0.007601807825267315,
-0.01352950930595398,
0.008142760023474693,
-0.04523502662777901,
-0.010932937264442444,
0.0346665196120739,
0.00855274498462677,
-0.0022933543659746647,
0.01939457468688488,
0.009441046044230461,
-0.016126081347465515,
-0.007749857846647501,
0.03644312173128128,
0.026125162839889526,
0.005520563572645187,
0.009361326694488525,
0.032981026917696,
-0.02464466169476509,
-0.03455263748764992,
0.00785235408693552,
-0.010579894296824932,
-0.02286805957555771,
-0.005756874568760395,
0.02699068747460842,
0.007681527175009251,
0.014383644796907902,
0.012310942634940147,
-0.010221157222986221,
-0.021729212254285812,
-0.014748075976967812,
-0.0046835108660161495,
-0.027742328122258186,
-0.018460718914866447,
-0.008279422298073769,
-0.004680663347244263,
-0.010579894296824932,
0.008102900348603725,
-0.011325838975608349,
0.019018754363059998,
-0.02102312631905079,
0.0009495141566731036,
0.005204533692449331,
0.02655792608857155,
-0.009036755189299583,
0.014884738251566887,
-0.000227057738811709,
0.009520765393972397,
-0.029974468052387238,
-0.021330615505576134,
-0.034005988389253616,
0.0012911685043945909,
0.011451112106442451,
-0.004139711149036884,
-0.06746532768011093,
0.00501662353053689,
0.030475560575723648,
-0.01593247801065445,
0.003314046422019601,
0.033345457166433334,
-0.008114289492368698,
-0.0013374341651797295,
-0.05079260095953941,
-0.00366139505058527,
-0.002802988514304161,
0.01823294907808304,
0.00392902409657836,
-0.021045902743935585,
-0.012538711540400982,
-0.006087140180170536,
0.01098418515175581,
-0.02879006788134575,
-0.025920171290636063,
-0.01990705542266369,
-0.04140849784016609,
-0.006798920221626759,
-0.017914071679115295,
-0.016080528497695923,
-0.021102845668792725,
0.04405062645673752,
-0.027651218697428703,
0.012789258733391762,
-0.020932018756866455,
0.01631968654692173,
0.023505814373493195,
0.05958450585603714,
-0.022013923153281212,
0.024553554132580757,
0.03735420107841492,
-0.0022663066629320383,
-0.005272864364087582,
0.00891148205846548,
0.0038606934249401093,
-0.01112084649503231,
-0.004051450174301863,
0.017128268256783485,
0.017253540456295013,
-0.023847468197345734,
0.0009616144234314561,
-0.010021858848631382,
-0.006451571360230446,
0.024439668282866478,
-0.04391396418213844,
0.02090924233198166,
-0.005554729141294956,
0.00857552234083414,
0.009845337830483913,
0.0226402897387743,
-0.014679745770990849,
0.009885197505354881,
0.0015189379919320345,
0.0019203817937523127,
0.010893077589571476,
-0.0009744264534674585,
0.017743244767189026,
0.02810675837099552,
-0.0008939953404478729,
0.014497529715299606,
-0.0005334789166226983,
0.023437483236193657,
0.004199500661343336,
0.03414265066385269,
0.012903142720460892,
0.01025532279163599,
0.023961354047060013,
-0.010898771695792675,
0.01670689322054386,
0.026352932676672935,
0.021034514531493187,
-0.0004829425597563386,
0.05170368030667305,
0.014725299552083015,
-0.0380147323012352,
-0.01671828329563141,
-0.017469922080636024,
0.0045667788945138454,
0.004082768689841032,
0.002301895758137107,
0.11634466797113419,
-0.009088004007935524,
-0.012823423370718956,
0.02548740804195404,
-0.021945593878626823,
-0.028197865933179855,
0.007476534228771925,
0.016251355409622192,
0.027469003573060036,
-0.007886519655585289,
0.027651218697428703,
0.017014382407069206,
0.018654324114322662,
-0.02302749827504158,
0.03550926595926285,
-0.018756819888949394,
-0.02195698209106922,
0.029154498130083084,
0.016627173870801926,
0.011923734098672867,
0.0023887327406555414,
0.01772046834230423,
-0.02095479518175125,
0.020248709246516228,
-0.022606125101447105,
0.0118781803175807,
-0.016536066308617592,
-0.02901783585548401,
0.00863815937191248,
0.010243933647871017,
0.02655792608857155,
-0.0063775465823709965,
0.010335042141377926,
-0.008006098680198193,
-0.01349534373730421,
-0.025532962754368782,
-0.018847927451133728,
-0.012515935115516186,
-0.0008228173828683794,
0.0015502562746405602,
0.006679341197013855,
-0.007761246524751186,
-0.012812035158276558,
0.01749269850552082,
0.03416542708873749,
0.012231223285198212,
-0.023050274699926376,
-0.01403060182929039,
-0.0012185669038444757,
-0.01497584581375122,
-0.005224463529884815,
-0.021615326404571533,
0.017082713544368744,
-0.025920171290636063,
-0.030498338863253593,
-0.01132014486938715,
0.011268896982073784,
-0.004942598752677441,
-0.014907514676451683,
-0.026649033650755882,
-0.025396300479769707,
0.02297055535018444,
0.035076506435871124,
0.018073510378599167,
0.009702981449663639
] | 2024-07-23 | 60 | 39042728 | [
"CAR tyrosine kinases",
"T cells",
"CAR",
"CARs",
"intracellular protein domains",
"high antitumor efficacy",
"chimeric adaptor proteins",
"adaptor domains",
"CAR-TK cell exhaustion",
"various blood cancers",
"ZAP70 domains",
"slower phosphorylation kinetics",
"CAR-TKs",
"adverse effects",
"CAPs",
"high tonic",
"TCRζ",
"upstream molecules",
"28ζ",
"long-term tumor clearance",
"Lck inhibition",
"an antitumor chimeric receptor",
"the conventional CD19-28ζ-CAR-T cells",
"leukemia-bearing NSG mice",
"the kinase domain",
"The distinct signaling properties",
"NSG",
"Lck",
"long-term function",
"the 28ζ-CAR"
] | [] | 0 | 10.1126/scisignal.adp8569
10.1056/NEJMra1706169
10.1182/blood-2011-10-384388
10.1182/blood-2010-04-281931
10.1056/NEJMoa1103849
10.1038/s41591-019-0564-6
10.1038/s41467-018-08064-2
10.1126/science.aaf1292
10.1126/science.282.5397.2263
10.1016/S0140-6736(21)01289-7
10.1016/j.it.2017.06.010
10.1038/nm.3838
10.1073/pnas.0911512106
10.1128/MCB.01637-12
10.1038/sj.cgt.7700710
10.1038/s41591-018-0290-5
10.1158/2159-8290.CD-19-0945
10.1126/scisignal.abe2606
10.1016/j.ymthe.2017.06.008
10.1038/s41591-018-0010-1
10.1038/nm.2446
10.1038/s41591-019-0737-3
10.1126/scisignal.aap9777
10.1126/scisignal.aat6753
10.15252/embj.2020104730
10.1016/j.xcrm.2023.100917
10.1186/s13287-022-02819-x
10.1038/s41590-020-0719-0
10.1038/s41467-019-10097-0
10.1038/s41467-018-05395-y
10.1126/scitranslmed.abb5191
10.1038/s41421-018-0066-6
10.1038/s41586-023-05778-2
10.3389/fcell.2020.608530
10.1016/j.tibs.2017.11.008
10.1038/mto.2016.14
10.1126/science.aba1786
10.1073/pnas.1716266115
10.1371/journal.pone.0144787
10.1182/blood.2020005185
10.1126/scitranslmed.aau5907
10.1016/j.ccell.2019.12.014
10.1097/CJI.0b013e3181ac6138
10.5281/zenodo.3555620
10.7717/peerj.453
10.1093/nar/gkv342
10.1146/annurev.biochem.77.062906.171838
10.1038/nprot.2015.053
10.1093/nar/gky427
10.1093/bioinformatics/btu426
10.1177/109434209400800104
10.7554/eLife.37854
10.1002/jcc.23899
10.1038/s41586-021-03819-2
10.1002/jcc.20084
10.1093/bioinformatics/btz502 | [
"Balagopalan",
"Moreno",
"Qin",
"Angeles",
"Kondo",
"Yi",
"McIntire",
"Alvinez",
"Pallikkuth",
"Lee",
"Yamane",
"Tran",
"Youkharibache",
"Cachau",
"Taylor",
"Samelson"
] | [
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.",
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.",
"Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.",
"Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.",
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.",
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.",
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.",
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.",
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.",
"Laboratory of Cancer Biology and Genetics (CCR Microscopy Core), National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Integrated Data Science Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.",
"Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.",
"Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA."
] | [
"39042728",
"29972754",
"22160384",
"20668228",
"21830940",
"31501612",
"30655520",
"7761445",
"28280247",
"9856951",
"34097851",
"28754596",
"25939063",
"9858619",
"11015445",
"19920178",
"14647385",
"23530057",
"15060573",
"30559421",
"32193224",
"34429382",
"28676342",
"29713085",
"21926977",
"31959992",
"30755478",
"30131370",
"32643825",
"15489916",
"36696897",
"35365241",
"32632291",
"31064990",
"30076299",
"33762437",
"30479831",
"36890224",
"33575254",
"29269020",
"11861607",
"27231717",
"33795428",
"29440406",
"26700307",
"32483603",
"31270272",
"32004441",
"19561539",
"25024921",
"25883148",
"18410248",
"25950237",
"29788355",
"24996895",
"30526845",
"25824339",
"34265844",
"15264254",
"31218344"
] | [] | 8.565756 | 4.645638 |
39039086 | 701 | C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial. | Chimeric antigen receptor (CAR) T cells show suboptimal efficacy in acute myeloid leukemia (AML). We find that CAR T cells exposed to myeloid leukemia show impaired activation and cytolytic function, accompanied by impaired antigen receptor downstream calcium, ZAP70, ERK, and C-JUN signaling, compared to those exposed to B-cell leukemia. These defects are caused in part by the high expression of CD155 by AML. Overexpressing C-JUN, but not other antigen receptor downstream components, maximally restores anti-tumor function. C-JUN overexpression increases costimulatory molecules and cytokines through reinvigoration of ERK or transcriptional activation, independent of anti-exhaustion. We conduct an open-label, non-randomized, single-arm, phase I trial of C-JUN-overexpressing CAR-T in AML (NCT04835519) with safety and efficacy as primary and secondary endpoints, respectively. Of the four patients treated, one has grade 4 (dose-limiting toxicity) and three have grade 1-2 cytokine release syndrome. Two patients have no detectable bone marrow blasts and one patient has blast reduction after treatment. Thus, overexpressing C-JUN endows CAR-T efficacy in AML. | [
0.015055103227496147,
0.017360949888825417,
0.0354539155960083,
0.05577952414751053,
-0.024851899594068527,
-0.004236535169184208,
0.007978960871696472,
0.0072042448446154594,
-0.009070882573723793,
-0.022192247211933136,
-0.025888921692967415,
-0.03235505148768425,
-0.04445769637823105,
0.028450973331928253,
0.01654353365302086,
-0.04701974615454674,
0.028231369331479073,
-0.018532173708081245,
0.013395870104432106,
0.023241467773914337,
0.023936882615089417,
0.002784706186503172,
0.020752618089318275,
0.024583494290709496,
-0.007216445170342922,
-0.013725276105105877,
0.0017720856703817844,
-0.023180466145277023,
-0.0006572882412001491,
-0.010553212836384773,
0.04262765869498253,
-0.024620095267891884,
-0.027279749512672424,
-0.017751356586813927,
-0.027157746255397797,
0.01238934975117445,
0.05133863538503647,
-0.003913228865712881,
-0.012834658846259117,
-0.04821537062525749,
0.03159863501787186,
0.012883459217846394,
0.003498420352116227,
0.053632281720638275,
-0.04716615006327629,
-0.0057219150476157665,
0.0126028535887599,
-0.0015723066171631217,
0.006539331749081612,
0.005740215536206961,
0.006856537889689207,
0.023656276986002922,
0.0017415850888937712,
0.05377868190407753,
-0.04162723943591118,
0.026425732299685478,
0.030159007757902145,
-0.011864738538861275,
-0.00398643035441637,
-0.02957339584827423,
0.009107483550906181,
-0.014262087643146515,
-0.03330666944384575,
-0.023668477311730385,
-0.03816236928105354,
-0.019752196967601776,
-0.044701699167490005,
-0.032330650836229324,
0.056804344058036804,
0.026572134345769882,
-0.016653334721922874,
-0.040212009102106094,
0.03284306079149246,
-0.01786115951836109,
0.026059724390506744,
-0.000308246846543625,
0.003498420352116227,
-0.008930579759180546,
0.010333607904613018,
0.023058464750647545,
0.02086242102086544,
0.01593352109193802,
0.02686494030058384,
-0.060074009001255035,
0.0247786995023489,
0.000265736598521471,
-0.01537230983376503,
-0.04884978383779526,
-0.0035655219107866287,
0.013725276105105877,
-0.021228427067399025,
-0.002125892788171768,
-0.06036681681871414,
0.04662933945655823,
0.02321706712245941,
0.04357927665114403,
0.016531333327293396,
-0.051631439477205276,
0.03113502636551857,
0.04677574336528778,
0.005569412373006344,
0.007545852102339268,
-0.005688364617526531,
-0.04084642231464386,
0.019959602504968643,
-0.0017080344259738922,
-0.04872778058052063,
-0.02896338328719139,
0.039601996541023254,
0.005032601300626993,
0.10043242573738098,
-0.002610852476209402,
-0.009906599298119545,
0.05494990572333336,
-0.04994780570268631,
-0.069004587829113,
-0.0788135901093483,
-0.004126733168959618,
0.006984640844166279,
-0.007704454939812422,
-0.016226327046751976,
0.027548154816031456,
0.04948419705033302,
-0.05475470423698425,
0.010370208881795406,
-0.01703154295682907,
0.10043242573738098,
0.017836758866906166,
-0.041700441390275955,
-0.033648278564214706,
0.021655436605215073,
0.01023600623011589,
-0.03169623762369156,
-0.017873359844088554,
-0.054413095116615295,
-0.007844758220016956,
-0.03823557123541832,
-0.009369788691401482,
-0.056462738662958145,
-0.020264608785510063,
0.019569193944334984,
0.011443830095231533,
-0.021631035953760147,
-0.0014869049191474915,
-0.05026501044631004,
-0.05455949902534485,
0.005057001952081919,
0.0026947292499244213,
-0.01495750155299902,
0.0665157362818718,
0.0024278489872813225,
0.056804344058036804,
0.02547411248087883,
0.009247786365449429,
0.010614213533699512,
-0.050753023475408554,
-0.011614633724093437,
0.026547733694314957,
-0.018227167427539825,
-0.05089942365884781,
0.02547411248087883,
-0.007856958545744419,
-0.030598215758800507,
-0.030037004500627518,
0.013542273081839085,
-0.004931949544698,
-0.02664533630013466,
0.02791416272521019,
-0.0507042221724987,
0.009955400601029396,
-0.014079083688557148,
-0.05324187129735947,
-0.06715015321969986,
-0.035819921642541885,
-0.046751342713832855,
-0.02116742543876171,
-0.0313546322286129,
0.009503991343080997,
-0.022265449166297913,
0.0019047633977606893,
0.04001680761575699,
0.030647017061710358,
0.027645757421851158,
0.014384089969098568,
-0.02674293890595436,
0.01764155551791191,
-0.0192519873380661,
0.050606619566679,
-0.05494990572333336,
-0.01986199989914894,
0.016189726069569588,
0.01594572141766548,
0.04216405004262924,
0.027108946815133095,
0.007124943658709526,
0.006661334075033665,
0.043872084468603134,
0.0364055335521698,
-0.046873342245817184,
-0.017446352168917656,
0.0067955367267131805,
-0.008052161894738674,
-0.026206128299236298,
-0.028450973331928253,
-0.00048152843373827636,
0.03191584348678589,
0.00026897728093899786,
-0.00071028305683285,
-0.0202524084597826,
0.020008403807878494,
0.07827677577733994,
0.014920900575816631,
-0.02796296402812004,
0.025059305131435394,
-0.006008620839565992,
-0.03857717663049698,
0.01434748899191618,
0.0343070924282074,
0.0008921429398469627,
-0.009912699460983276,
-0.008778076618909836,
-0.03672273829579353,
0.013151864521205425,
-0.011956240981817245,
-0.04179804027080536,
0.01384727843105793,
0.004456139635294676,
-0.020264608785510063,
0.018739577382802963,
-0.007515351288020611,
-0.01859317533671856,
0.01121202576905489,
0.004767246078699827,
-0.04306686669588089,
-0.04333527386188507,
-0.023900281637907028,
0.00921118538826704,
-0.0054108090698719025,
0.0710054263472557,
-0.009223385713994503,
-0.012261247262358665,
0.023107266053557396,
0.01384727843105793,
-0.004983800463378429,
0.019020183011889458,
-0.010571513324975967,
-0.014823298901319504,
-0.07905758917331696,
0.028621776029467583,
-0.024986103177070618,
0.016165325418114662,
0.04301806539297104,
-0.014518292620778084,
0.013395870104432106,
0.002752680331468582,
0.022985262796282768,
0.036478735506534576,
-0.03101302497088909,
0.011529232375323772,
-0.012578452937304974,
0.027401750907301903,
0.010461710393428802,
-0.053632281720638275,
-0.04960620030760765,
-0.008466970175504684,
0.04338407516479492,
0.015970122069120407,
0.002183843869715929,
0.018739577382802963,
-0.015201506204903126,
0.04133443161845207,
0.020264608785510063,
0.02372947707772255,
0.004511040635406971,
-0.033599477261304855,
-0.006545431911945343,
-0.002828931901603937,
0.042481254786252975,
0.026572134345769882,
0.0033032165374606848,
-0.0035045205149799585,
0.0013839653693139553,
-0.000871555064804852,
-0.018849380314350128,
-0.01143162976950407,
-0.04372568055987358,
0.011883039027452469,
-0.04411608725786209,
0.00609707273542881,
-0.011126624420285225,
0.018007563427090645,
-0.024449292570352554,
-0.0037424254696816206,
-0.023192666471004486,
-0.0414564348757267,
0.016921740025281906,
-0.0002409548469586298,
-0.015201506204903126,
-0.039650797843933105,
0.012340548448264599,
-0.0006904576439410448,
0.020142605528235435,
-0.046482935547828674,
-0.05006980895996094,
0.02691374160349369,
0.02747495286166668,
-0.003025660989806056,
-0.028670577332377434,
0.01611652411520481,
0.05324187129735947,
0.029378192499279976,
0.013530072756111622,
0.03323346748948097,
0.02386368066072464,
0.01684853993356228,
-0.026279328390955925,
-0.02155783399939537,
-0.06407569348812103,
0.05187544599175453,
-0.014420690014958382,
-0.026669736951589584,
-0.02230204828083515,
-0.032159846276044846,
-0.004660493694245815,
0.004541541449725628,
0.01672653667628765,
0.01326166745275259,
-0.007118843495845795,
0.01125472690910101,
-0.040529217571020126,
-0.005545011721551418,
-0.05207064747810364,
0.0372595489025116,
-0.03403868526220322,
0.019020183011889458,
0.003958979621529579,
-0.04457969591021538,
-0.03186704218387604,
0.004956349730491638,
0.033160269260406494,
-0.004959399811923504,
0.022497253492474556,
-0.004520190879702568,
0.0546083003282547,
-0.007570252288132906,
-0.008887878619134426,
0.01662893407046795,
0.0005444359849207103,
-0.00405963184311986,
0.02730415016412735,
-0.007545852102339268,
-0.0021914690732955933,
0.007643453776836395,
0.012096543796360493,
0.026620935648679733,
0.021740837022662163,
-0.04028521105647087,
-0.01920318603515625,
-0.00289145833812654,
0.011376729235053062,
0.027450552210211754,
0.010791117325425148,
-0.040651217103004456,
0.04504330828785896,
0.07715435326099396,
0.048190969973802567,
-0.03496590256690979,
0.03662513568997383,
-0.013700875453650951,
-0.04384768381714821,
-0.039040785282850266,
0.009534492157399654,
0.024046683683991432,
0.010437309741973877,
0.011486531235277653,
0.031159427016973495,
0.02216784656047821,
-0.00019596645142883062,
0.04758095741271973,
0.0039650797843933105,
0.024156486615538597,
-0.03391668200492859,
0.025108106434345245,
-0.02913418598473072,
0.004181634169071913,
0.00872927624732256,
0.021704237908124924,
-0.010095703415572643,
-0.051143430173397064,
0.03474630042910576,
0.0012878883862867951,
-0.02630372904241085,
0.01650693267583847,
-0.03818676993250847,
-0.009571093134582043,
0.0787159875035286,
-0.012639454565942287,
0.06436849385499954,
0.03774756193161011,
-0.0018163116183131933,
-0.012047742493450642,
-0.02818256802856922,
0.0011079348623752594,
-0.038308773189783096,
0.02242405153810978,
-0.042871661484241486,
-0.0025254508946090937,
-0.0034801200963556767,
0.011498731561005116,
-0.026596534997224808,
0.004145033657550812,
0.0206794161349535,
0.05514511093497276,
0.014408489689230919,
-0.01876397803425789,
-0.034648697823286057,
-0.04433569312095642,
0.052851464599370956,
-0.04006560519337654,
0.052802663296461105,
0.013054262846708298,
-0.045702122151851654,
0.018605373799800873,
0.021179625764489174,
0.019178785383701324,
-0.004099282436072826,
0.05207064747810364,
-0.0005814179312437773,
0.0476541593670845,
-0.04084642231464386,
-0.00027183673228137195,
0.01579931750893593,
0.00827176682651043,
-0.033160269260406494,
-0.004096232354640961,
0.04882538318634033,
-0.02552291378378868,
0.031330231577157974,
-0.05821957066655159,
0.02664533630013466,
-0.008046061731874943,
0.03306266665458679,
-0.01454269327223301,
-0.02552291378378868,
0.004135883413255215,
0.03196464478969574,
-0.01728774793446064,
0.010486111044883728,
-0.03262345865368843,
0.03462429717183113,
-0.0466049388051033,
-0.05348587781190872,
-0.023497672751545906,
0.01903238333761692,
-0.031379032880067825,
-0.029329391196370125,
0.03984600305557251,
-0.008735375478863716,
0.020362209528684616,
0.04462849721312523,
0.014359689317643642,
-0.051631439477205276,
0.0015829819021746516,
0.008875678293406963,
-0.008161964826285839,
0.02242405153810978,
0.021521233022212982,
-0.020057203248143196,
0.0302566085010767,
0.004035231191664934,
0.022460652515292168,
-0.00803386140614748,
0.004663543775677681,
0.042652059346437454,
-0.011346228420734406,
0.045580118894577026,
0.030232209712266922,
0.0083388676866889,
0.037210747599601746,
0.00988829880952835,
-0.0372595489025116,
-0.04655613750219345,
-0.0053711580112576485,
-0.01864197477698326,
0.031086226925253868,
0.048752181231975555,
-0.009479590691626072,
-0.017800157889723778,
-0.010455610230565071,
0.03828437253832817,
-0.004669643938541412,
-0.021740837022662163,
0.02442489191889763,
-0.011785437352955341,
0.03386788070201874,
-0.008771976456046104,
0.027108946815133095,
-0.00864387396723032,
0.00502040097489953,
-0.011590233072638512,
-0.0232536680996418,
0.017055943608283997,
0.012578452937304974,
0.014896499924361706,
0.010553212836384773,
0.049703799188137054,
-0.006197724957019091,
0.04162723943591118,
0.017970962449908257,
0.03474630042910576,
-0.010229906067252159,
-0.0048404475674033165,
0.019886400550603867,
-0.016360528767108917,
-0.07051742076873779,
-0.0375523567199707,
-0.04560451954603195,
0.007393348962068558,
0.012749256566166878,
0.0002655459684319794,
-0.01984979957342148,
-0.020350009202957153,
0.01867857575416565,
-0.004141983576118946,
0.027987362816929817,
-0.03540511429309845,
-0.0025696768425405025,
-0.011309627443552017,
-0.011950140818953514,
-0.031379032880067825,
0.053193069994449615,
-0.006844338029623032,
0.020093804225325584,
-0.00916848424822092,
-0.020764818415045738,
-0.01598232239484787,
-0.009247786365449429,
0.04433569312095642,
-0.013286067172884941,
-0.00630142679437995,
-0.0052583059296011925,
-0.012883459217846394,
0.011730535887181759,
-0.021887240931391716,
-0.005331507418304682,
0.019093384966254234,
-0.009381989017128944,
-0.016043322160840034,
0.01989860087633133,
-0.01794656179845333,
0.041090428829193115,
-0.047751761972904205,
0.012895659543573856,
-0.008003361523151398,
-0.00011780862405430526,
-0.006194674875587225,
-0.020276809111237526,
-0.013957081362605095,
-0.010144504718482494,
-0.0283045694231987,
-0.0020145655144006014,
0.019923001527786255,
0.0004155708593316376,
-0.0072896466590464115,
-0.030720219016075134,
-0.009680895134806633,
0.004816046915948391,
-0.01326166745275259,
-0.030500615015625954,
0.035819921642541885,
-0.014359689317643642,
0.0013092388398945332,
-0.0056761642917990685,
-0.0027618305757641792,
0.03557591512799263,
0.02394908294081688,
-0.00044912155135534704,
0.054413095116615295,
0.007088342681527138,
0.015274707227945328,
-0.006392928771674633,
-0.015957921743392944,
-0.004385988228023052,
0.0375523567199707,
-0.03835757076740265,
0.0012047742493450642,
-0.027987362816929817,
-0.032721057534217834,
-0.008869579061865807,
0.03789396211504936,
0.025059305131435394,
-0.0019566144328564405,
0.040309611707925797,
0.011968441307544708,
-0.03801596537232399,
0.019398391246795654,
0.02552291378378868,
-0.0365031361579895,
-0.02006940357387066,
0.01842237077653408,
0.03442909196019173,
-0.008875678293406963,
-0.03128143027424812,
-0.020886819809675217,
-0.010071302764117718,
0.032159846276044846,
0.005108852870762348,
-0.0021975692361593246,
-0.010199405252933502,
0.01764155551791191,
0.034551095217466354,
0.01703154295682907,
-0.04160283878445625,
0.019447190687060356,
0.028597375378012657,
0.013273866847157478,
0.007460450287908316,
-0.011761036701500416,
0.011047322303056717,
-0.021582234650850296,
-0.015201506204903126,
-0.005706665106117725,
-0.022448452189564705,
0.015091704204678535,
0.01326166745275259,
-0.03367267921566963,
0.005349807906895876,
0.009034281596541405,
0.01877617835998535,
-0.0019977902993559837,
-0.03225744888186455,
-0.02769455686211586,
-0.042139649391174316,
0.012749256566166878,
0.0036143227480351925,
-0.03130583092570305,
0.014835498295724392,
-0.030549414455890656,
-0.017824558541178703,
-0.010095703415572643,
-0.023156065493822098,
0.002238745102658868,
-0.01317626517266035,
-0.025888921692967415,
0.010425110347568989,
0.0044134389609098434,
-0.001452591735869646,
-0.0057615661062300205,
0.019447190687060356,
-0.021069824695587158,
-0.010663014836609364,
-0.02146023139357567,
-0.00024190799740608782,
-0.02691374160349369,
-0.0018071613740175962,
-0.039919205009937286,
0.013700875453650951,
-0.017531752586364746,
0.0748119056224823,
0.07715435326099396,
-0.025669317692518234,
0.01393268071115017,
-0.02825576812028885,
0.005432159174233675,
-0.030012603849172592,
0.002621527761220932,
0.028426572680473328,
0.01276145689189434,
0.023046264424920082,
-0.0037881762254983187,
0.07920399308204651,
0.004547641612589359,
-0.014493891969323158,
-0.018019763752818108,
0.009540592320263386,
0.017055943608283997,
0.004456139635294676,
-0.007930159568786621,
-0.053632281720638275,
-0.004507990553975105,
0.01512830425053835,
-0.01332266815006733,
-0.046702541410923004,
-0.05504750832915306,
-0.020435411483049393,
-0.001765985507518053,
0.024839701130986214,
0.007710555102676153,
0.00844866968691349,
-0.018751777708530426,
-0.01276145689189434,
0.026596534997224808,
-0.026010923087596893,
0.005929319187998772,
0.02603532373905182,
0.011437729932367802,
-0.014115684665739536,
-0.012846858240664005,
-0.03664953634142876,
0.016616733744740486,
0.037820760160684586,
0.016580134630203247,
0.04475050047039986,
0.015030702576041222,
0.0041480837389826775,
-0.035819921642541885,
-0.009906599298119545,
-0.03713754937052727,
0.025620516389608383,
0.026230528950691223,
0.01589692011475563,
-0.003066836856305599,
-0.02564491704106331,
-0.0157261174172163,
-0.004977700300514698,
-0.003233065130189061,
0.01004080194979906,
0.06202604994177818,
0.007722755428403616,
0.011602433398365974,
0.016384929418563843,
0.04616573080420494,
-0.018519973382353783,
-0.006996840704232454,
0.023363471031188965,
0.011022921651601791,
-0.038699179887771606,
0.05714594945311546,
-0.011370629072189331,
-0.0116268340498209,
-0.003916278947144747,
-0.000357810320565477,
-0.009503991343080997,
-0.010473910719156265,
-0.0182027667760849,
0.0375523567199707,
-0.02268025651574135,
-0.0021640185732394457,
-0.023326870054006577,
-0.016775337979197502,
0.02891458198428154,
-0.03184264153242111,
-0.011706136167049408,
0.026279328390955925,
-0.02455909363925457,
0.04072441905736923,
0.02786536142230034,
-0.005365057848393917,
-0.013212866149842739,
-0.012230746448040009,
0.005871368106454611,
0.009064782410860062,
0.019190985709428787,
0.023436671122908592,
-0.009564992971718311,
-0.0322086475789547,
-0.008723176084458828,
-0.004276186227798462,
-0.03762555867433548,
-0.01999620348215103,
-0.023546474054455757,
0.011004621163010597,
0.008460870012640953,
0.01847117207944393,
-0.009430790320038795,
0.027230948209762573,
0.029451392590999603,
0.008924479596316814,
0.005572461988776922,
0.03713754937052727,
-0.002580351894721389,
-0.015469911508262157,
0.027645757421851158,
-0.021936042234301567,
0.003971179947257042,
0.033941082656383514,
-0.01579931750893593,
-0.028206968680024147,
0.0018452871590852737,
-0.008967180736362934,
-0.0034740199334919453,
0.028841380029916763,
-0.005901868920773268,
0.03347747400403023,
-0.00844866968691349,
-0.006807737052440643,
-0.022106844931840897,
0.009522291831672192,
-0.037649959325790405,
-0.010107903741300106,
-0.013164064846932888,
0.01955699361860752,
-0.015408909879624844,
0.028548574075102806,
-0.006182474549859762,
0.04401848465204239,
0.03911398723721504,
-0.08593852818012238,
-0.03140343353152275,
-0.029646597802639008,
-0.027938563376665115,
-0.008046061731874943,
0.014164485037326813,
-0.028426572680473328,
-0.006691834889352322,
0.02869497798383236,
0.005520611070096493,
0.022058043628931046,
-0.022143445909023285,
-0.005712765268981457,
-0.012968861497938633,
-0.010900919325649738,
-0.0056822644546628,
-0.02438829094171524,
-0.020886819809675217,
0.0029860101640224457,
0.05148503556847572,
0.015250307507812977,
-0.03740595281124115,
0.005310156848281622,
0.049581799656152725,
0.00032959727104753256,
-0.007301846984773874,
-0.00940638966858387,
-0.004544591531157494,
-0.046531736850738525,
0.03013460710644722,
0.03306266665458679,
-0.00025563326198607683,
-0.005008200649172068,
0.043481674045324326,
-0.003958979621529579,
-0.019874200224876404,
0.017617154866456985,
-0.03418508917093277,
-0.02233864925801754,
-0.0027679307386279106,
0.014750096946954727,
0.007222545333206654,
0.012438150122761726,
0.01794656179845333,
-0.013408070430159569,
0.00014440134691540152,
-0.02591332234442234,
0.0019169636070728302,
0.013469071127474308,
-0.04245685413479805,
0.006033021491020918,
0.004858748055994511,
-0.03713754937052727,
0.03330666944384575,
-0.013725276105105877,
-0.004395138472318649,
0.004129783250391483,
0.022460652515292168,
0.034648697823286057,
-0.0035380711778998375,
-0.0014335288433358073,
0.04933779314160347,
0.008375468663871288,
-0.01060201320797205,
0.01495750155299902,
0.008674374781548977,
-0.05192424729466438,
0.0333554707467556,
-0.03957759588956833,
-0.01786115951836109,
-0.01004080194979906,
0.004663543775677681,
-0.04394528642296791,
0.034648697823286057,
-0.0113645289093256,
-0.002026765840128064,
-0.024937301874160767,
-0.020703816786408424,
-0.010583712719380856,
0.011096123605966568,
-0.018666375428438187,
-0.032647859305143356,
-0.026938142254948616,
0.003650923492386937,
-0.03374588117003441,
-0.013920480385422707,
-0.018397970125079155,
0.006783336400985718,
0.012188045307993889,
-0.01348127145320177,
0.010913119651377201,
0.018044162541627884,
-0.028402172029018402,
0.0202524084597826,
-0.011724435724318027,
-0.031208228319883347,
-0.05616993084549904,
0.01265165489166975,
0.001688209013082087,
0.0056853145360946655,
0.03845517337322235,
-0.04292046278715134,
0.02230204828083515,
-0.02808496542274952,
0.007314047310501337,
-0.015445510856807232,
0.038211170583963394,
-0.023900281637907028,
-0.015713917091488838,
-0.010870418511331081,
0.04292046278715134,
0.006466130260378122,
-0.0035990725737065077,
-0.014798898249864578,
0.009992001578211784,
0.01594572141766548,
0.0009905074257403612,
0.0012589128455147147,
0.010577612556517124,
-0.008631673641502857,
0.04023640975356102,
0.03159863501787186,
0.006575932260602713,
-0.026986943557858467,
-0.011510931886732578,
0.013444670476019382,
0.03403868526220322,
-0.00462694326415658,
0.0030897122342139482,
-0.010120104067027569,
0.037430353462696075,
0.030720219016075134,
0.011010721325874329,
-0.015701716765761375,
0.00699074100703001,
-0.009632093831896782,
0.03684474155306816,
0.0111022237688303,
0.018910380080342293,
0.0045262910425662994,
-0.022436251863837242,
-0.005898818839341402,
0.02482750080525875,
-0.023180466145277023,
0.02355867438018322,
-0.01245645061135292,
-0.0322086475789547,
0.03828437253832817,
-0.018788378685712814,
0.023583075031638145,
-0.008967180736362934,
0.015921320766210556,
0.033770281821489334,
0.036161527037620544,
0.0126028535887599,
0.018275968730449677,
-0.000986694823950529,
-0.03589312359690666,
-0.024071084335446358,
0.025449711829423904,
-0.005429109558463097,
0.03013460710644722,
-0.05168024078011513,
-0.005005150567740202,
0.0393579937517643,
0.0037820760626345873,
0.0026581285055726767,
0.009705295786261559,
0.01664113439619541,
0.03491710498929024,
0.0434572733938694,
-0.046800144016742706,
0.04626333341002464,
-0.010406809858977795,
-0.008546272292733192,
-0.014359689317643642,
0.0005539674311876297,
-0.0033977683633565903,
0.013957081362605095,
0.0293049905449152,
-0.06724775582551956,
0.015823718160390854,
0.010742316022515297,
0.0325014553964138,
0.016689935699105263,
-0.0029036584310233593,
0.00803386140614748,
-0.027377352118492126,
0.03469749912619591,
-0.01816616579890251,
-0.015006301924586296,
-0.028426572680473328,
0.016360528767108917,
0.030598215758800507,
0.024095484986901283,
-0.013456870801746845,
-0.0030119356233626604,
0.025791319087147713,
-0.058512378484010696,
-0.04245685413479805,
-0.010205505415797234,
0.03645433485507965,
0.04018760845065117,
-0.017690356820821762,
-0.02464449591934681,
0.00521560525521636,
-0.0047245449386537075,
-0.019276387989521027,
-0.008161964826285839,
0.054364293813705444,
-0.012590653263032436,
0.047410156577825546,
-0.04279846325516701,
0.03057381510734558,
-0.00030214671278372407,
-0.017214545980095863,
-0.007686154916882515,
0.0036356733180582523,
-0.01265165489166975,
-0.022411851212382317,
-0.037601158022880554,
-0.030549414455890656,
0.01645813137292862,
-0.011132724583148956,
0.023680677637457848,
0.0065210312604904175,
0.030329810455441475,
0.0009386563906446099,
0.007143243681639433,
0.034941501915454865,
-0.0363079309463501,
0.022192247211933136,
0.0012406124733388424,
-0.006447829771786928,
-0.014005881734192371,
-0.0072042448446154594,
-0.016689935699105263,
-0.021191826090216637,
-0.016567934304475784,
0.008869579061865807,
0.03601512685418129,
0.05128983408212662,
-0.009418589994311333,
-0.008668274618685246,
-0.02038661018013954,
-0.007063942030072212,
0.029670996591448784,
-0.0037454753182828426,
-0.005886618513613939,
0.001211636932566762,
-0.02364407666027546,
-0.0059415195137262344,
0.0565115362405777,
0.034770701080560684,
0.03806476667523384,
0.00992489978671074,
0.006636933423578739,
0.011602433398365974,
0.030281009152531624,
0.010534912347793579,
-0.0014388664858415723,
0.012328348122537136,
-0.030769020318984985,
-0.018385769799351692,
-0.015055103227496147,
-0.005154603626579046,
-0.016958341002464294,
-0.011303527280688286,
0.0038308771327137947,
0.034160688519477844,
0.014664695598185062,
0.009912699460983276,
-0.0103885093703866,
0.007942359894514084,
-0.010290907695889473,
-0.005731065291911364,
0.04131003096699715,
-0.0023332969285547733,
-0.010510511696338654,
-0.0029433092568069696,
0.004852647893130779,
0.004767246078699827,
-0.016519133001565933,
0.007503150962293148,
0.019215386360883713,
0.004120633006095886,
-0.023961283266544342,
-0.005084452219307423,
0.00552976131439209,
-0.0008982431027106941,
-0.00030138419242575765,
0.01876397803425789,
-0.0002573489327915013,
-0.009192884899675846,
0.023888081312179565,
-0.032111044973134995,
0.010486111044883728,
-0.02160663530230522,
0.0118891391903162,
-0.03164743632078171,
-0.00864387396723032,
0.014420690014958382,
-0.0005722677451558411,
-0.02111862599849701,
0.008332767523825169,
-0.015189305879175663,
-0.037210747599601746,
-0.028646176680922508,
0.045092109590768814,
-0.01049221120774746,
-0.03613712638616562,
0.033550675958395004,
0.01559191383421421,
-0.012206345796585083,
0.03694234415888786,
-0.009369788691401482,
-0.03740595281124115,
0.014811098575592041,
-0.010809417814016342,
0.007466550450772047,
-0.003434369107708335,
0.0022097695618867874,
0.023180466145277023,
0.007643453776836395,
-0.024705497547984123,
-0.015103904530405998,
0.02189944125711918,
-0.010559312999248505,
-0.006185524631291628,
-0.01686074025928974,
0.015201506204903126,
-0.009357588365674019,
0.020106004551053047,
0.016177525743842125,
-0.009656494483351707,
0.02586452104151249,
-0.007960660383105278,
-0.006350228097289801,
-0.021972643211483955,
-0.01916658505797386,
-0.002278395928442478,
-0.0024735997430980206,
0.005130203440785408,
-0.0015875570243224502,
0.02674293890595436,
0.011266927234828472,
0.004538491368293762,
-0.026279328390955925,
-0.0017522602574899793,
-0.027767758816480637,
0.05612112954258919,
-0.04045601561665535,
-0.01711694523692131,
0.03691794350743294,
-0.021045424044132233,
0.00008716503361938521,
-0.01976439729332924,
0.011529232375323772,
0.010742316022515297,
0.023241467773914337,
-0.027621356770396233,
0.029402591288089752,
0.026108525693416595,
-0.009247786365449429,
0.012590653263032436,
0.011754936538636684,
-0.03408748656511307,
-0.013554473407566547,
0.005734115373343229,
0.019886400550603867,
0.027450552210211754,
0.03662513568997383,
0.007527551613748074,
0.026816140860319138,
-0.001884937984868884,
0.0059506697580218315,
0.05255865678191185,
0.013310467824339867,
-0.012529652565717697,
0.042871661484241486,
0.0012840759009122849,
0.007094442844390869,
-0.007399449124932289,
-0.04094402492046356,
-0.010687415488064289,
-0.0118891391903162,
-0.022655855864286423,
-0.037479154765605927,
-0.006478330586105585,
-0.02208244428038597,
-0.015738317742943764,
0.004745895508676767,
-0.008985481224954128,
0.014676895923912525,
-0.035600315779447556,
-0.021740837022662163,
0.003248315304517746,
0.0008685049833729863,
-0.027450552210211754,
0.014420690014958382,
-0.0166777353733778,
-0.0322086475789547,
0.01306646317243576,
0.000114472619316075,
0.012517452239990234,
0.0030226109083741903,
-0.013200665824115276,
0.03906518593430519,
-0.02464449591934681,
-0.0034313190262764692,
-0.025937722995877266,
-0.016433730721473694,
-0.055974725633859634,
0.009857798926532269,
-0.01786115951836109,
-0.015018502250313759,
-0.013115264475345612,
-0.0026932042092084885,
-0.005285756662487984,
-0.006874838378280401,
0.018312567844986916,
0.01362767443060875,
-0.017177945002913475,
0.02020360715687275,
-0.004355487879365683,
0.0005501548293977976,
0.012493051588535309,
0.002128942869603634,
-0.03289186209440231,
0.03518550843000412,
-0.0003877390699926764,
0.015469911508262157,
0.025376511737704277,
-0.010858219116926193,
-0.026157326996326447,
0.005111902952194214,
-0.00929658766835928,
0.040309611707925797,
-0.017397550866007805,
0.008961080573499203,
-0.002063366584479809,
-0.0116268340498209,
0.03596632555127144,
0.010968021117150784,
0.012907859869301319,
-0.012102643959224224,
-0.003840027377009392,
0.0006672009476460516,
0.022851061075925827,
0.029597796499729156,
0.030647017061710358,
0.014445090666413307,
-0.02996380254626274,
-0.010382409207522869,
-0.029841801151633263,
-0.031232628971338272,
-0.025327710434794426,
-0.0228266604244709,
0.020545214414596558,
0.03457549586892128,
-0.025937722995877266,
0.01784895919263363,
0.014994101598858833,
-0.003596022492274642,
0.00858287326991558,
-0.00018767408619169146,
0.004849597811698914,
-0.02996380254626274,
-0.028816979378461838,
0.005404708907008171,
-0.0025742517318576574,
0.03796716406941414,
0.01537230983376503,
0.004806896671652794,
0.04636093229055405,
-0.007216445170342922,
0.0010995471384376287,
-0.0011147974291816354,
-0.005108852870762348,
-0.0033703178633004427,
-0.05329067260026932,
0.0033032165374606848,
0.021216226741671562,
-0.016189726069569588,
0.026669736951589584,
0.006136723794043064,
-0.007192044984549284,
-0.02291206084191799,
0.015384510159492493,
0.03040301240980625,
-0.014213286340236664,
0.005853068083524704,
-0.0217286366969347,
-0.00552976131439209,
0.000827329175081104,
0.011071722954511642,
-0.016909539699554443,
-0.02603532373905182,
-0.024888500571250916,
0.016885140910744667,
-0.02133822999894619,
-0.005804266780614853,
0.006777236703783274,
-0.025400912389159203,
-0.003812576876953244,
-0.04257885739207268,
-0.03550271317362785,
-0.03891878202557564,
0.001245187595486641,
0.01889817975461483,
-0.0008624048787169158,
-0.0075946529395878315,
-0.010510511696338654,
0.016580134630203247,
0.03174503892660141,
-0.010974121280014515,
0.0009035806870087981,
0.04982580244541168,
0.009595492854714394,
-0.016092123463749886,
-0.013054262846708298,
0.02268025651574135,
0.0212040264159441,
-0.0068260375410318375,
-0.03528311103582382,
-0.05021621286869049,
0.01404248271137476,
0.016787538304924965,
-0.010394609533250332,
0.019093384966254234,
0.03999240696430206,
-0.013249467127025127,
0.020240208134055138,
0.016567934304475784,
0.005401658825576305,
0.05143623426556587,
0.025449711829423904,
-0.005917119327932596,
-0.004013880621641874,
0.0015890819486230612,
-0.02996380254626274,
0.003785126144066453,
0.04575091972947121,
-0.027840960770845413,
0.012011141516268253,
0.01703154295682907,
0.02164323627948761,
-0.0008372418815270066,
0.007917959243059158,
0.01623852737247944,
0.023534273728728294,
0.0023820979986339808,
-0.007692255079746246,
0.02355867438018322,
-0.00012695881014224142,
-0.02796296402812004,
0.032647859305143356,
0.019971802830696106,
-0.03664953634142876,
0.0011544482549652457,
0.02935379184782505,
0.01445729099214077,
0.005557212047278881,
-0.0011933365603908896,
0.0016805838095024228,
-0.012242946773767471,
-0.011913539841771126,
-0.009479590691626072,
-0.04218845069408417,
-0.018544374033808708,
-0.01789776049554348,
-0.028280168771743774,
0.003553321585059166,
-0.03162303566932678,
-0.023351270705461502,
0.03872358053922653,
-0.012883459217846394,
-0.003916278947144747,
0.02055741474032402,
0.000997370108962059,
-0.041822440922260284,
0.01794656179845333,
-0.03479510173201561,
-0.006200775038450956,
-0.01750735193490982,
-0.004925849381834269,
-0.022582653909921646,
-0.006124523468315601,
0.007680054754018784,
-0.00390712870284915,
-0.02320486679673195,
0.004706244915723801,
-0.0007285834290087223,
-0.016494732350111008,
0.019971802830696106,
0.018739577382802963,
-0.010778916999697685,
-0.017482951283454895,
-0.03877238184213638,
-0.005291856359690428,
-0.01969119720160961,
0.019837599247694016,
0.029060985893011093,
-0.024180887266993523,
-0.0002779368369374424,
-0.03208664432168007,
0.00486789783462882,
-0.019325189292430878,
-0.010510511696338654,
-0.019910801202058792,
-0.017787957563996315,
-0.0075946529395878315,
-0.021801838651299477,
0.013993681408464909,
-0.01989860087633133,
0.026620935648679733,
-0.026401331648230553,
0.01733654923737049,
-0.007338447961956263,
0.0011430105660110712,
-0.006856537889689207,
0.044530898332595825,
-0.048922985792160034,
0.003072936786338687,
0.008375468663871288,
0.01197454147040844,
-0.010778916999697685,
0.0059049190022051334,
-0.009766296483576298,
-0.011334028095006943,
-0.023631876334547997,
0.013944881036877632,
0.011803737841546535,
-0.03752795606851578,
-0.009680895134806633,
-0.03379467874765396,
-0.00788135826587677,
0.02360747568309307,
-0.01754395291209221,
-0.006514931097626686,
-0.005273556336760521,
0.006661334075033665,
0.0007087580161169171,
0.02221664786338806,
-0.0228266604244709,
0.0293049905449152,
0.008515771478414536,
-0.01177933719009161,
0.0075946529395878315,
-0.022485053166747093,
-0.01837356947362423,
-0.004019980784505606,
0.00539860874414444,
0.011962341144680977,
0.02033780887722969,
0.03074461966753006,
0.017348749563097954,
0.03096422366797924,
0.011895239353179932,
-0.012364949099719524,
0.02098442241549492,
-0.004114532843232155,
0.00901598110795021,
0.016799738630652428,
0.012993261218070984,
0.0063685281202197075,
0.028646176680922508,
0.01064471434801817,
-0.04694654420018196,
0.026791740208864212,
-0.02847537398338318,
-0.015116104856133461,
-0.04858137667179108,
-0.007710555102676153,
0.11087583005428314,
0.009461290203034878,
0.009009881876409054,
0.03379467874765396,
-0.013090863823890686,
-0.006807737052440643,
0.0018224116647616029,
0.031208228319883347,
0.009241686202585697,
-0.009205085225403309,
0.009223385713994503,
0.047312553972005844,
0.02774335816502571,
0.006447829771786928,
0.012920060195028782,
-0.01701934263110161,
-0.0395531952381134,
0.025815719738602638,
-0.001463267020881176,
0.019739996641874313,
-0.0006096310098655522,
0.010717915371060371,
-0.011401129886507988,
0.019483791664242744,
-0.032647859305143356,
-0.016433730721473694,
-0.0038857783656567335,
-0.03786956146359444,
0.001712609431706369,
-0.007076142355799675,
-0.013700875453650951,
0.011065622791647911,
-0.01847117207944393,
-0.015689516440033913,
0.0055999127216637135,
-0.014725696295499802,
-0.028768179938197136,
-0.034258291125297546,
0.020215807482600212,
0.007985061034560204,
0.002389723202213645,
0.002632203046232462,
0.021448031067848206,
0.012377149425446987,
0.03694234415888786,
-0.019605794921517372,
-0.04160283878445625,
-0.0033215167932212353,
0.023741677403450012,
-0.014323088340461254,
-0.004925849381834269,
0.020960021764039993,
0.01955699361860752,
-0.020520813763141632,
-0.01606772281229496,
-0.0343070924282074,
0.009510091505944729,
-0.004486640449613333,
0.0010225330479443073,
-0.015201506204903126,
-0.03518550843000412,
0.04821537062525749,
0.0027130297385156155,
-0.005465710069984198,
0.013957081362605095
] | 2024-07-23 | 68 | 39039086 | [
"impaired antigen receptor downstream calcium",
"CAR T cells",
"leukemia show impaired activation",
"anti-tumor function",
"suboptimal efficacy",
"acute myeloid leukemia",
"efficacy",
"AML",
"blast reduction",
"cytolytic function",
"cytokines",
"costimulatory molecules",
"ERK",
"CAR",
"CAR-T efficacy",
"C-JUN",
"C-JUN overexpression",
"B-cell leukemia",
"ERK or transcriptional activation",
"no detectable bone marrow blasts",
"part",
"C-JUN-overexpressing CAR-T",
"safety",
"reinvigoration",
"myeloid",
"CD155",
"dose-limiting toxicity",
"-",
"ZAP70, ERK",
"treatment"
] | [] | 0 | 10.1038/s41467-024-50485-9
10.1056/NEJMra1406184
10.1007/s11864-017-0456-2
10.1200/JCO.2010.31.8121
10.1038/s41591-019-0564-6
10.3389/fonc.2022.967754
10.1182/blood.2020006921
10.1038/s41375-021-01232-2
10.1038/mt.2014.164
10.3389/fonc.2019.01358
10.1158/1078-0432.CCR-20-4543
10.1002/cam4.5916
10.1091/mbc.e02-03-0149
10.1089/jir.1998.18.197
10.1007/s12031-019-1260-1
10.1186/s12882-022-03001-4
10.1038/bcj.2014.18
10.1002/glia.20653
10.1016/S0960-9822(00)00512-1
10.1007/s10555-008-9123-1
10.1038/s41577-018-0020-8
10.1038/s41392-021-00823-w
10.4049/jimmunol.0900092
10.4049/jimmunol.168.2.689
10.7150/ijbs.41105
10.1038/s41577-019-0224-6
10.1038/s41388-018-0288-y
10.1038/s41590-018-0131-1
10.1016/j.coi.2023.102397
10.3389/fimmu.2022.880108
10.1136/jitc-2020-001229
10.1158/2326-6066.CIR-16-0376
10.1038/srep06138
10.1016/j.bone.2017.05.012
10.1093/biolre/ioz222
10.1158/0008-5472.CAN-12-0995
10.1186/s12967-023-03984-0
10.1038/354494a0
10.1093/emboj/cdg388
10.1038/s41467-019-08871-1
10.1172/jci.insight.120974
10.1111/imr.12823
10.1186/s12967-022-03480-x
10.1111/imr.12518
10.1038/s41586-023-05778-2
10.1016/j.ccell.2019.12.014
10.1158/2326-6066.CIR-19-0293
10.1038/s41586-019-1805-z
10.1016/j.ccell.2021.12.005
10.1126/scitranslmed.add7900
10.1073/pnas.2104758118
10.1038/nm.3838
10.1089/hum.2017.241
10.3390/cells9112470
10.1136/jitc-2021-003149
10.1038/s41591-018-0036-4
10.1182/blood-2018-99-110579
10.1016/j.cell.2018.05.013
10.1002/cpz1.246
10.1016/j.immuni.2020.09.006
10.1182/blood-2012-03-416040
10.1038/ncomms13720
10.1186/s13059-014-0550-8
10.1073/pnas.0506580102
10.1016/j.ccell.2022.09.013
10.1038/nmeth.2688
10.1016/j.bbmt.2018.12.758 | [
"Zuo",
"Li",
"Sun",
"Deng",
"Zhang",
"Han",
"Ling",
"Xu",
"Duan",
"Wang",
"Yu",
"Zheng",
"Xu",
"Zong",
"Tian",
"Shan",
"Tang",
"Huang",
"Song",
"Niu",
"Zhou",
"Feng",
"Han",
"Wang",
"Wu",
"Pan",
"Feng"
] | [
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.\nTianjin Institutes of Health Science, Tianjin, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.\nTianjin Institutes of Health Science, Tianjin, China.\nCentral laboratory, Fujian Medical University Union Hospital, Fuzhou, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.\nTianjin Institutes of Health Science, Tianjin, China.",
"Cytology Laboratory, Beijing GoBroad Boren Hospital, Beijing, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.\nTianjin Institutes of Health Science, Tianjin, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.\nTianjin Institutes of Health Science, Tianjin, China.",
"Department of Hematology, Beijing GoBroad Boren Hospital, Beijing, China.",
"Department of Hematology, Beijing GoBroad Boren Hospital, Beijing, China.",
"Department of Hematology, Beijing GoBroad Boren Hospital, Beijing, China.",
"Department of Hematology, Beijing GoBroad Boren Hospital, Beijing, China.",
"Medical Laboratory, Beijing GoBroad Boren Hospital, Beijing, China.",
"Medical Laboratory, Beijing GoBroad Boren Hospital, Beijing, China.",
"Medical Laboratory, Beijing GoBroad Boren Hospital, Beijing, China.",
"Medical Laboratory, Beijing GoBroad Boren Hospital, Beijing, China.",
"Gobroad Research Center, Gobroad Medical Group, Beijing, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.\nTianjin Institutes of Health Science, Tianjin, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.\nTianjin Institutes of Health Science, Tianjin, China.",
"Central laboratory, Fujian Medical University Union Hospital, Fuzhou, China.",
"Department of Bone Marrow Transplantation, Beijing GoBroad Boren Hospital, Beijing, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.\nTianjin Institutes of Health Science, Tianjin, China.",
"Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.\nTianjin Institutes of Health Science, Tianjin, China.",
"Institute of Stem Cells, Health-Biotech (Tianjin) Stem Cell Research Institute Co., Ltd, Tianjin, China.",
"Department of Hematology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China. [email protected].",
"Department of Bone Marrow Transplantation, Beijing GoBroad Boren Hospital, Beijing, China. [email protected].",
"State Key Laboratory of Experimental Hematology, Boren Clinical Translational Center, Department of Hematology, Beijing GoBroad Boren Hospital, Beijing, China. [email protected].",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. [email protected].\nTianjin Institutes of Health Science, Tianjin, China. [email protected].\nCentral laboratory, Fujian Medical University Union Hospital, Fuzhou, China. [email protected]."
] | [
"39039086",
"26376137",
"28286924",
"21282535",
"31501612",
"36523990",
"33094319",
"33833386",
"25174587",
"31850234",
"33832948",
"37031462",
"12475968",
"9555982",
"30649683",
"36575400",
"24681962",
"18338791",
"10837247",
"18330678",
"29789755",
"34897277",
"19380816",
"11777962",
"32398947",
"31676858",
"29855615",
"32489646",
"29915297",
"37931499",
"35615350",
"32938629",
"28550091",
"25138242",
"28506888",
"31836902",
"22986738",
"36829235",
"1749429",
"12881422",
"30911002",
"30385732",
"31883174",
"35729552",
"28258695",
"36890224",
"32004441",
"31953246",
"31802004",
"34971569",
"37467316",
"34285077",
"25939063",
"29409351",
"33202877",
"34531250",
"29808007",
"29856956",
"34529358",
"33053331",
"22723548",
"28008905",
"25516281",
"16199517",
"36240777",
"24097267",
"30592986",
"7581076"
] | [] | 6.899868 | 7.15047 |
39037052 | 702 | Targeting Tumor-Associated Sialic Acids Using Chimeric Switch Receptors Based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells. | Cancer exploits different mechanisms to escape T-cell immunosurveillance, including overexpression of checkpoint ligands, secretion of immunosuppressive molecules, and aberrant glycosylation. Herein, we report that IFNγ, a potent immunomodulator secreted in the tumor microenvironment, can induce α2,6 hypersialylation in cancer cell lines derived from various histologies. We focused on Siglec-9, a receptor for sialic acid moieties, and demonstrated that the Siglec-9+ T-cell population displayed reduced effector function. We speculated that Siglec-9 in primary human T cells can act as a checkpoint molecule and demonstrated that knocking out Siglec-9 using a clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system enhanced the functionality of primary human T cells. Finally, we aimed to augment cancer-specific T-cell activity by taking advantage of tumor hypersialylation. Thus, we designed several Siglec-9-based chimeric switch receptors (CSR), which included an intracellular moiety derived from costimulatory molecules (CD28/41BB) and different hinge regions. In an antigen-specific context, T cells transduced with Siglec-9 CSRs demonstrated increased cytokine secretions and upregulation of activation markers. Moreover, T cells equipped with specific Siglec-9 CSRs mediated robust antitumor activity in a xenograft model of human tumors. Overall, this work sheds light on tumor evasion mechanisms mediated by sialylated residues and exemplifies an approach to improve engineered T cell-based cancer treatment. See related Spotlight by Abken, p. 1310. | [
0.004858135711401701,
0.02103022299706936,
0.013609880581498146,
0.0584159716963768,
-0.029373671859502792,
-0.013680888339877129,
0.010893821716308594,
0.02338532544672489,
-0.015917642042040825,
-0.025539236143231392,
-0.0008683695341460407,
-0.04288887605071068,
-0.011858347803354263,
0.012710444629192352,
0.001420901040546596,
0.006443982478231192,
0.032166656106710434,
-0.019124839454889297,
0.021278752014040947,
0.01853310689330101,
0.010816896334290504,
0.03143290430307388,
-0.049563631415367126,
0.021965162828564644,
-0.020012442022562027,
-0.004207228310406208,
0.03654548525810242,
-0.011745918542146683,
0.004662863444536924,
0.004438004456460476,
0.049090247601270676,
-0.03050980158150196,
0.015207561664283276,
-0.013408690690994263,
-0.04298355057835579,
0.008307944051921368,
0.017349638044834137,
-0.007520938292145729,
-0.03633246198296547,
-0.0014467894798144698,
0.025373550131917,
0.030486131086945534,
-0.002213084837421775,
0.035433027893304825,
-0.031409237533807755,
-0.022545062005519867,
-0.006032727193087339,
-0.06296049058437347,
0.008272440172731876,
0.009621593169867992,
-0.016686895862221718,
0.002192374086007476,
-0.002170184161514044,
0.06523274630308151,
-0.01647387258708477,
0.01637919433414936,
-0.043007221072912216,
0.04445105046033859,
-0.030959518626332283,
-0.018982823938131332,
0.0020488786976784468,
-0.020000606775283813,
0.011053590103983879,
-0.0023595390375703573,
-0.023906050249934196,
0.004130302928388119,
-0.03957516327500343,
0.016675062477588654,
-0.012982642278075218,
-0.006799022667109966,
0.017823025584220886,
-0.03339746221899986,
0.009645262733101845,
0.02189415507018566,
0.012887964956462383,
-0.030675485730171204,
0.0193852037191391,
0.03185895457863808,
0.03287673741579056,
-0.0516938753426075,
0.02819020487368107,
-0.0016583342803642154,
0.03879407420754433,
-0.040095891803503036,
-0.024852825328707695,
-0.003562238300219178,
0.016178006306290627,
0.011461885645985603,
-0.10367178171873093,
0.026699034497141838,
0.04369363188743591,
0.009023942053318024,
-0.02306578867137432,
0.03138556703925133,
0.007142228540033102,
0.006580081302672625,
-0.02620197832584381,
-0.05983613431453705,
0.04035625234246254,
0.026059960946440697,
0.06196637451648712,
-0.02442677691578865,
-0.00972810573875904,
-0.05354008451104164,
0.024947501718997955,
-0.028403228148818016,
-0.021799476817250252,
0.008834587410092354,
0.03583540767431259,
0.011396795511245728,
0.13652485609054565,
0.009574254974722862,
-0.03166959807276726,
0.04407234117388725,
-0.021941494196653366,
-0.05529161915183067,
-0.050226375460624695,
-0.02404806576669216,
0.03948048874735832,
0.05197790637612343,
0.018391089513897896,
0.041610728949308395,
-0.006887782830744982,
-0.007899647578597069,
-0.014402803964912891,
-0.03772895410656929,
0.039551496505737305,
-0.020450323820114136,
-0.04016689956188202,
-0.01961006224155426,
0.05633306875824928,
-0.032166656106710434,
0.039267461746931076,
0.0010022493079304695,
-0.022852763533592224,
-0.001366905402392149,
-0.007065303158015013,
-0.01564544439315796,
-0.021586453542113304,
0.0488535538315773,
-0.005920297931879759,
-0.010799144394695759,
0.008722158148884773,
-0.0043936241418123245,
-0.041894759982824326,
-0.09231048822402954,
-0.01366905402392149,
0.025444557890295982,
-0.00608302466571331,
0.07782484591007233,
0.012112793512642384,
0.028971292078495026,
0.05103113502264023,
0.021278752014040947,
-0.03155125305056572,
-0.020710688084363937,
0.010633458383381367,
0.02594161592423916,
-0.029421010985970497,
-0.0013018145691603422,
-0.03240334987640381,
0.02695939689874649,
-0.021361595019698143,
0.006390726193785667,
-0.0010155633790418506,
-0.02601262368261814,
0.003022280987352133,
0.024190083146095276,
-0.04961097240447998,
-0.011485555209219456,
-0.04260484129190445,
-0.05401347205042839,
-0.05202524736523628,
0.011029920540750027,
-0.05306669697165489,
0.0019172178581357002,
0.018793469294905663,
0.0011945628793910146,
-0.03053347021341324,
0.008686654269695282,
-0.026699034497141838,
0.027574799954891205,
0.028876615688204765,
-0.001653896295465529,
0.02591794542968273,
-0.021042058244347572,
-0.009071281179785728,
0.004526764620095491,
0.0024512577801942825,
-0.0060948594473302364,
-0.003671708982437849,
-0.018036050722002983,
0.05794258415699005,
-0.02157461829483509,
-0.03443891555070877,
0.0006816035020165145,
0.018473932519555092,
0.04352794587612152,
0.010154154151678085,
-0.02112490125000477,
0.030083753168582916,
-0.02667536586523056,
-0.014154274947941303,
-0.029089638963341713,
-0.009254718199372292,
-0.005476497579365969,
-0.018828973174095154,
0.033823512494564056,
-0.004955771379172802,
0.009657097980380058,
0.04087698087096214,
0.013302178122103214,
0.015349578112363815,
0.01764550618827343,
-0.017302298918366432,
0.025775929912924767,
0.02331431582570076,
-0.006177701987326145,
0.02828488126397133,
0.005923256743699312,
-0.03668750450015068,
0.013550707139074802,
0.01653304509818554,
-0.02055683732032776,
-0.027456453070044518,
-0.007810887880623341,
0.0010562450625002384,
-0.022071674466133118,
-0.02939734049141407,
0.009864204563200474,
-0.0017500530229881406,
0.03465193882584572,
0.025397220626473427,
-0.05794258415699005,
-0.030367784202098846,
0.01698276400566101,
0.009077198803424835,
0.018556775525212288,
0.027953511103987694,
-0.026533348485827446,
0.024213751778006554,
0.002877306193113327,
0.022545062005519867,
0.053398068994283676,
-0.03268738090991974,
0.024781815707683563,
0.003656915621832013,
-0.069966621696949,
-0.010491442866623402,
-0.000749652914237231,
-0.04184742271900177,
0.03708988055586815,
0.009414486587047577,
0.006361139472573996,
0.004242732189595699,
0.012698610313236713,
0.027125082910060883,
-0.01526673510670662,
0.015467924997210503,
-0.011071342043578625,
-0.008390787057578564,
-0.0005932132480666041,
-0.029350003227591515,
-0.032237663865089417,
-0.053587425500154495,
-0.023870546370744705,
0.026557018980383873,
0.015183892101049423,
0.014402803964912891,
-0.024947501718997955,
0.0005170275107957423,
0.05964677780866623,
0.03574072942137718,
0.0073019964620471,
-0.04004855081439018,
0.009674849919974804,
-0.009420404210686684,
0.04580020532011986,
-0.003420222084969282,
0.013432360254228115,
-0.031054196879267693,
-0.02565758302807808,
-0.001195302465930581,
-0.003227908629924059,
-0.032545365393161774,
-0.015456089749932289,
0.0011834678007289767,
-0.027101414278149605,
-0.01357437577098608,
-0.011219275183975697,
0.04130302742123604,
0.0014689794043079019,
-0.015941312536597252,
0.008467712439596653,
-0.033752501010894775,
0.03408387303352356,
0.0005591885419562459,
-0.01859227940440178,
-0.06078290939331055,
0.005961719434708357,
-0.022272864356637,
-0.014095102436840534,
-0.004582979250699282,
-0.04776476323604584,
-0.013420525006949902,
-0.006195453926920891,
-0.0119116036221385,
0.004801920615136623,
0.02316046506166458,
0.040403593331575394,
0.02385871112346649,
-0.02714875154197216,
-0.005272349342703819,
0.04795411601662636,
-0.0010828730883076787,
0.0035237756092101336,
0.011479638516902924,
-0.0063374703750014305,
0.0380839966237545,
-0.034036535769701004,
-0.031598590314388275,
0.006189536768943071,
-0.03285306692123413,
-0.0015022645238786936,
-0.0064321476966142654,
-0.03484129160642624,
0.002955710981041193,
0.013408690690994263,
0.020982885733246803,
0.0043492442928254604,
0.06343387812376022,
-0.033089760690927505,
0.04970565065741539,
-0.0017500530229881406,
0.0031687351875007153,
-0.03503064811229706,
-0.07635734230279922,
0.03339746221899986,
0.007479516789317131,
0.042628511786460876,
-0.04501911625266075,
0.021716635674238205,
-0.03867572918534279,
-0.0005477237282320857,
0.002448299201205373,
-0.0016169128939509392,
-0.03559871390461922,
0.054818231612443924,
-0.0160241536796093,
0.00744401291012764,
0.05638040974736214,
0.06599016487598419,
0.010296170599758625,
0.021598288789391518,
-0.00333442073315382,
0.03339746221899986,
-0.0021716635674238205,
-0.06911452114582062,
0.013278509490191936,
0.005041573196649551,
0.02807185798883438,
-0.01287612970918417,
-0.009828700684010983,
0.0392911322414875,
0.07086605578660965,
0.045539841055870056,
-0.027645809575915337,
0.04828548803925514,
0.010704467073082924,
-0.007183649577200413,
-0.02762213908135891,
0.06982460618019104,
0.043575286865234375,
-0.00022670805628877133,
-0.0070120468735694885,
0.010633458383381367,
-0.028568914160132408,
0.012899799272418022,
0.008870091289281845,
-0.009858286939561367,
0.04880621284246445,
-0.025681251659989357,
-0.04527948051691055,
-0.037137221544981,
-0.0277878250926733,
-0.017467984929680824,
0.016213510185480118,
-0.028308549895882607,
-0.10263033211231232,
0.03370516374707222,
0.0008365638204850256,
-0.026557018980383873,
0.007769466377794743,
0.021870486438274384,
-0.033468469977378845,
0.008089003153145313,
-0.028213873505592346,
0.03436790779232979,
0.04243915528059006,
0.015432421118021011,
0.012248892337083817,
-0.04345693811774254,
0.00377822108566761,
-0.062108393758535385,
-0.034131214022636414,
-0.059220731258392334,
0.0430782288312912,
0.02062784507870674,
0.050889115780591965,
0.007035716436803341,
-0.02939734049141407,
0.01404776331037283,
0.04556351155042648,
-0.007313831243664026,
-0.023669356480240822,
-0.04007222130894661,
-0.019976936280727386,
0.03488863259553909,
0.037492260336875916,
0.009964799508452415,
0.012083206325769424,
-0.06840444356203079,
0.02714875154197216,
-0.02068701758980751,
0.008716240525245667,
-0.010562450625002384,
-0.0016879210015758872,
0.02401256188750267,
0.030012743547558784,
-0.038699399679899216,
-0.030367784202098846,
0.049752987921237946,
-0.0026790753472596407,
-0.04201310873031616,
-0.04679431766271591,
0.0366164967417717,
-0.0026672405656427145,
-0.02639133296906948,
-0.03576439991593361,
0.022911937907338142,
-0.04565818980336189,
0.01818990148603916,
-0.042557504028081894,
-0.046297263354063034,
0.03621411696076393,
0.03330278396606445,
0.0037279236130416393,
-0.01707744039595127,
-0.01213054545223713,
-0.01441463828086853,
0.02743278443813324,
-0.050037018954753876,
-0.015183892101049423,
0.029539357870817184,
0.0005288621759973466,
-0.03332645446062088,
0.05084177851676941,
-0.06286580860614777,
0.032261334359645844,
-0.02420191653072834,
0.030438793823122978,
-0.03344479948282242,
-0.007136310916393995,
0.006367057096213102,
-0.020414819940924644,
0.025018509477376938,
0.0024571751710027456,
0.021929658949375153,
0.00910678505897522,
0.0059173391200602055,
0.032450687140226364,
-0.030296776443719864,
0.012544759549200535,
0.004798962268978357,
-0.009586089290678501,
0.016828913241624832,
0.027693146839737892,
-0.022284699603915215,
0.022852763533592224,
-0.009722188115119934,
-0.026912059634923935,
-0.053871456533670425,
-0.02103022299706936,
-0.0009297619108110666,
0.030178429558873177,
-0.020829033106565475,
0.006574163679033518,
-0.042817868292331696,
0.019633730873465538,
0.028426896780729294,
0.029705042019486427,
-0.037870969623327255,
0.06049887463450432,
-0.010657127946615219,
0.022545062005519867,
-0.021314255893230438,
0.03884141519665718,
-0.014876190572977066,
-0.007124476600438356,
-0.008071250282227993,
0.010384930297732353,
0.02191782370209694,
0.019468046724796295,
0.02490016259253025,
0.02021363005042076,
0.0047279540449380875,
-0.003979410510510206,
0.02527887374162674,
-0.028332220390439034,
-0.0022574649192392826,
-0.02201250195503235,
-0.023610183969140053,
0.04177641496062279,
-0.015432421118021011,
-0.011029920540750027,
-0.02892395481467247,
-0.015858469530940056,
-0.02318413555622101,
-0.002247109543532133,
-0.02882927656173706,
-0.0033876767847687006,
-0.01694726012647152,
0.01024883147329092,
0.006793105509132147,
-0.0033521726727485657,
-0.03836802765727043,
-0.03519633412361145,
-0.05524427816271782,
-0.023562844842672348,
-0.04378831014037132,
0.013846573419868946,
-0.05609637498855591,
0.050321053713560104,
0.08170662075281143,
-0.002977900905534625,
0.0017293423879891634,
-0.011663075536489487,
-0.013432360254228115,
-0.01878163404762745,
-0.002492679050192237,
0.02845056727528572,
-0.024024397134780884,
0.04830915853381157,
-0.0008617124985903502,
-0.004695408511906862,
0.009698518551886082,
0.005532712209969759,
0.00004364037522464059,
0.008574224077165127,
-0.009976633824408054,
0.025397220626473427,
-0.03817867115139961,
0.024781815707683563,
-0.009858286939561367,
-0.01840292476117611,
0.024592461064457893,
0.010201492346823215,
-0.0008084564469754696,
-0.007077137473970652,
0.01235540397465229,
-0.018615949898958206,
-0.030959518626332283,
-0.0015207561664283276,
-0.031219881027936935,
0.022343872115015984,
-0.002190894912928343,
-0.01979941688477993,
0.029894398525357246,
0.0010525466641411185,
0.05604903772473335,
-0.012532924301922321,
0.0035119408275932074,
-0.0057723643258214,
-0.01357437577098608,
0.0647120252251625,
-0.000576200895011425,
-0.057137828320264816,
-0.002167225582525134,
0.019468046724796295,
0.022284699603915215,
0.0016435409197583795,
-0.008213266730308533,
-0.001391314435750246,
0.011710414662957191,
-0.012077289633452892,
-0.0009711832972243428,
0.0062013715505599976,
0.01530223898589611,
-0.007538690231740475,
-0.03727923706173897,
0.01492352969944477,
-0.007171815261244774,
0.00972810573875904,
-0.007586028892546892,
-0.031125204637646675,
0.0031006857752799988,
0.019823085516691208,
-0.010680797509849072,
-0.021077562123537064,
-0.0036066181492060423,
0.02433209866285324,
0.001989705255255103,
-0.002727893413975835,
-0.03545669838786125,
-0.005334481131285429,
0.0392911322414875,
0.00020840129582211375,
-0.005881835240870714,
0.029752381145954132,
-0.00494097825139761,
0.04419068992137909,
0.02658068761229515,
-0.037492260336875916,
-0.027077743783593178,
-0.00904169399291277,
0.005367026664316654,
-0.008816835470497608,
-0.004180599935352802,
0.008047581650316715,
-0.02620197832584381,
0.0009637866169214249,
0.010319839231669903,
-0.017385141924023628,
-0.0001665176241658628,
0.016485707834362984,
-0.03235601261258125,
-0.017479820176959038,
-0.024734478443861008,
-0.009952964261174202,
-0.018036050722002983,
0.025420889258384705,
-0.025633912533521652,
-0.013811069540679455,
0.0027293728198856115,
0.006479486357420683,
-0.000028638996809604578,
0.003221991239115596,
0.007094889879226685,
-0.0021361594554036856,
0.01669873110949993,
0.0021657461766153574,
-0.005479455925524235,
-0.007958821021020412,
-0.03803665563464165,
0.025207864120602608,
0.020769860595464706,
-0.0020414821337908506,
0.03266371414065361,
0.03164593130350113,
-0.007532772608101368,
0.0034853126853704453,
-0.006875948049128056,
0.014698670245707035,
-0.015846634283661842,
0.017562663182616234,
0.00034468501689843833,
0.036474477499723434,
-0.009716271422803402,
0.07668871432542801,
-0.0021953328978270292,
-0.03732657432556152,
0.05822661891579628,
-0.0077280448749661446,
-0.013444194570183754,
-0.03200097009539604,
-0.02873459830880165,
0.020000606775283813,
-0.03133822977542877,
-0.0002662802580744028,
-0.024876493960618973,
0.0522146001458168,
0.00955058541148901,
0.061635006219148636,
-0.004313740413635969,
0.0018447304610162973,
0.021870486438274384,
-0.021716635674238205,
-0.01287612970918417,
-0.04776476323604584,
0.012781452387571335,
-0.0013905747327953577,
-0.0005602980381809175,
-0.009491411969065666,
-0.04828548803925514,
-0.012710444629192352,
0.005296018440276384,
-0.0025429765228182077,
-0.0066333371214568615,
0.00009597184543963522,
-0.020485827699303627,
0.002060713479295373,
0.03053347021341324,
-0.006038644816726446,
-0.054250165820121765,
0.022450385615229607,
-0.00762745039537549,
0.008864174596965313,
0.011071342043578625,
-0.018462099134922028,
-0.00569543894380331,
0.03439157456159592,
-0.00454747537150979,
0.015479759313166142,
-0.03335012495517731,
0.01474600937217474,
-0.045634519308805466,
-0.012438246980309486,
-0.012911634519696236,
0.008302027359604836,
0.02008344978094101,
-0.03072282485663891,
0.029231656342744827,
-0.01964556612074375,
-0.025491897016763687,
-0.0009282825631089509,
-0.0430782288312912,
-0.017598167061805725,
0.028237542137503624,
0.05159919708967209,
-0.016686895862221718,
0.008118589408695698,
-0.03664016351103783,
0.01719578728079796,
0.0012463395250961185,
0.030628148466348648,
0.022036170586943626,
-0.04918492212891579,
0.041137341409921646,
-0.011645323596894741,
-0.014982703141868114,
-0.01488802582025528,
-0.025633912533521652,
-0.02819020487368107,
-0.012651271186769009,
0.020237300544977188,
0.01568094827234745,
-0.031196212396025658,
-0.03406020626425743,
-0.012035868130624294,
-0.01669873110949993,
0.025728590786457062,
-0.0232196394354105,
0.009645262733101845,
0.023551009595394135,
-0.0142371179535985,
0.019373368471860886,
0.01675790548324585,
0.010781392455101013,
0.02353917621076107,
-0.03041512332856655,
0.025633912533521652,
0.008165928535163403,
-0.016260847449302673,
-0.00917187612503767,
-0.009674849919974804,
-0.01058020256459713,
-0.0009778402745723724,
0.01357437577098608,
0.005035655573010445,
0.010012137703597546,
-0.008165928535163403,
0.0027944634202867746,
0.017207622528076172,
0.05230927839875221,
-0.007296079304069281,
0.04191843047738075,
-0.009592006914317608,
0.017657339572906494,
-0.003988286480307579,
0.05197790637612343,
0.0015932435635477304,
-0.01966923475265503,
-0.0022086468525230885,
-0.014675001613795757,
0.015053710900247097,
0.01062754075974226,
-0.01749165542423725,
-0.0044113765470683575,
0.010432269424200058,
-0.0017840777290984988,
0.027669478207826614,
-0.0020429613068699837,
0.005654017440974712,
0.010083146393299103,
-0.019787581637501717,
-0.01764550618827343,
0.024497784674167633,
0.01840292476117611,
0.00518063036724925,
-0.030438793823122978,
-0.021184073761105537,
0.01798871159553528,
-0.03602476045489311,
0.012781452387571335,
-0.02125508151948452,
0.03493596985936165,
0.023361654952168465,
-0.10367178171873093,
-0.00940856896340847,
0.02546822838485241,
0.037776295095682144,
0.005393654573708773,
-0.009461825713515282,
-0.0013920540222898126,
0.011083176359534264,
-0.007154063321650028,
-0.0046332767233252525,
0.017018267884850502,
0.00021764713164884597,
0.005115539766848087,
-0.008947016671299934,
0.013243005611002445,
-0.017574496567249298,
-0.04258117452263832,
-0.03311343118548393,
0.012627601623535156,
0.02695939689874649,
0.009668932296335697,
-0.002134680049493909,
0.004559309687465429,
0.037018872797489166,
0.022769920527935028,
-0.020284639671444893,
-0.022769920527935028,
0.022758087143301964,
-0.02724342979490757,
-0.032829396426677704,
-0.022320203483104706,
-0.008793165907263756,
-0.00544099323451519,
0.03602476045489311,
0.002733810804784298,
-0.03614310920238495,
0.030959518626332283,
0.01761000230908394,
-0.018888147547841072,
0.02911330945789814,
0.02667536586523056,
-0.005177672021090984,
0.0392911322414875,
0.019527219235897064,
-0.017479820176959038,
0.01139087788760662,
-0.0270540751516819,
-0.004585938062518835,
0.008071250282227993,
-0.021692965179681778,
0.0037634277250617743,
-0.011692662723362446,
-0.014166110195219517,
0.006071189884096384,
-0.01263943687081337,
-0.023231472820043564,
0.01116601936519146,
0.0038107663858681917,
0.011124597862362862,
0.001710111042484641,
-0.026059960946440697,
0.006562329363077879,
0.04473508521914482,
0.003577031660825014,
0.0016760863363742828,
-0.002004498615860939,
-0.030959518626332283,
0.018036050722002983,
-0.009254718199372292,
-0.02017812617123127,
0.0027086620684713125,
0.0022012502886354923,
-0.04419068992137909,
0.025444557890295982,
-0.007242823019623756,
0.004479425959289074,
-0.006763518787920475,
-0.007615615613758564,
-0.004050418734550476,
0.05112580955028534,
-0.016462037339806557,
-0.003272288478910923,
0.009970716200768948,
0.027361776679754257,
-0.04061661660671234,
-0.007686623837798834,
-0.006071189884096384,
0.046391937881708145,
0.02334981970489025,
0.0046332767233252525,
0.014544819481670856,
-0.03664016351103783,
0.013219336047768593,
0.02293560653924942,
0.022627905011177063,
-0.019172178581357002,
-0.029705042019486427,
0.009467742405831814,
-0.015858469530940056,
-0.010805061087012291,
0.05363476276397705,
-0.0018787551671266556,
-0.02527887374162674,
-0.008810917846858501,
-0.016497541218996048,
0.014177944511175156,
0.019598226994276047,
0.0034024701453745365,
0.007284244522452354,
0.016959093511104584,
-0.014012259431183338,
-0.012521089985966682,
0.02762213908135891,
-0.02613097056746483,
0.011035837233066559,
-0.012029950506985188,
0.027858832851052284,
0.010870152153074741,
0.00454747537150979,
-0.006911452393978834,
0.04655762389302254,
0.031977299600839615,
-0.002446819795295596,
0.03060447797179222,
0.012047702446579933,
0.028142865747213364,
0.01837925612926483,
-0.03408387303352356,
-0.0036628330126404762,
0.029941735789179802,
0.0048877219669520855,
-0.013503368012607098,
0.02461613155901432,
0.0019408873049542308,
-0.021610122174024582,
0.04743339121341705,
0.01742064580321312,
0.027006736025214195,
0.03900710120797157,
0.02490016259253025,
0.019917763769626617,
-0.030083753168582916,
-0.03053347021341324,
0.011503307148814201,
0.004429128486663103,
-0.004488301929086447,
-0.044522061944007874,
-0.008053498342633247,
-0.021882319822907448,
-0.004121426958590746,
-0.042178794741630554,
-0.006461734417825937,
0.039196453988552094,
0.024379437789320946,
0.013171996921300888,
-0.007574194110929966,
0.0426521822810173,
-0.027953511103987694,
-0.01146780326962471,
0.002591794589534402,
-0.027077743783593178,
0.034793954342603683,
-0.022722583264112473,
-0.009586089290678501,
-0.0040977573953568935,
0.0005399571964517236,
-0.018391089513897896,
0.013065485283732414,
0.013124658726155758,
0.02236754260957241,
-0.011183771304786205,
-0.06802573055028915,
0.0670316219329834,
0.0008239895105361938,
-0.03723189979791641,
0.0068522789515554905,
0.012556593865156174,
0.020604174584150314,
0.0011686744401231408,
0.01713661476969719,
-0.014568489044904709,
-0.007479516789317131,
0.02565758302807808,
0.02968137338757515,
0.054060809314250946,
-0.03668750450015068,
0.014757843688130379,
-0.010810978710651398,
-0.009799113497138023,
0.00300600822083652,
-0.024734478443861008,
-0.009006190113723278,
0.014296291396021843,
0.03595375269651413,
0.018485767766833305,
-0.0015237148618325591,
-0.04340960085391998,
-0.009130454622209072,
-0.0442853681743145,
-0.012734114192426205,
-0.03455726057291031,
0.012911634519696236,
0.029444679617881775,
-0.024024397134780884,
0.00021246945834718645,
0.021243248134851456,
0.007941069081425667,
-0.04168173670768738,
-0.02176397293806076,
0.026367664337158203,
0.010124566964805126,
0.06101960316300392,
-0.005861124489456415,
0.013124658726155758,
-0.0009859766578301787,
-0.007029798813164234,
0.026272986084222794,
0.01798871159553528,
-0.03192996233701706,
-0.020982885733246803,
-0.003378800582140684,
-0.014686835929751396,
0.000852096825838089,
0.022663408890366554,
-0.020059779286384583,
0.0292079858481884,
0.025894276797771454,
0.0058640833012759686,
-0.039835527539253235,
0.007420343346893787,
0.004263442941009998,
0.025420889258384705,
0.023811373859643936,
-0.009018025361001492,
0.023243308067321777,
0.010396764613687992,
0.001202699146233499,
-0.04530314728617668,
0.026367664337158203,
0.0023003655951470137,
0.025799598544836044,
0.03237967938184738,
-0.0008106754976324737,
-0.018982823938131332,
0.017030103132128716,
-0.0032308672089129686,
0.04632093012332916,
-0.030202100053429604,
-0.002646530047059059,
-0.009905626066029072,
0.012805121950805187,
0.02223736047744751,
0.011793256737291813,
0.04932694137096405,
0.032332342118024826,
0.005334481131285429,
0.0019290526397526264,
0.0033166685607284307,
0.029468350112438202,
0.012319900095462799,
0.035433027893304825,
-0.02807185798883438,
-0.018367420881986618,
0.011745918542146683,
0.012911634519696236,
-0.012592097744345665,
0.01132578682154417,
-0.005535671021789312,
-0.015467924997210503,
0.035906415432691574,
0.005352233536541462,
0.01745615154504776,
-0.01357437577098608,
0.0005625170306302607,
0.0068522789515554905,
-0.009923378005623817,
0.00795290432870388,
0.0046539874747395515,
-0.032261334359645844,
-0.02391788549721241,
0.003757510334253311,
0.01134353969246149,
0.014663166366517544,
0.005881835240870714,
0.019550887867808342,
0.020793529227375984,
0.00036650520632974803,
-0.01194119080901146,
0.04130302742123604,
-0.013598045334219933,
0.011302118189632893,
0.02658068761229515,
-0.02622564695775509,
0.009461825713515282,
-0.031314559280872345,
-0.03060447797179222,
0.01427262183278799,
-0.017846694216132164,
-0.021207744255661964,
-0.02121957764029503,
0.004124385304749012,
0.016592219471931458,
-0.0069883777759969234,
-0.0025429765228182077,
0.03344479948282242,
0.02433209866285324,
-0.03848637267947197,
-0.04622625559568405,
0.04435637593269348,
-0.019965102896094322,
-0.03855738043785095,
-0.002068110043182969,
0.036663834005594254,
0.0050238207913935184,
0.022036170586943626,
-0.0007677747635170817,
0.012260726653039455,
0.031598590314388275,
-0.003736799815669656,
-0.005032697226852179,
-0.0015296321362257004,
0.002764876699075103,
0.0014741570921614766,
0.009479577653110027,
-0.032900404185056686,
-0.021799476817250252,
0.001525194151327014,
-0.041421376168727875,
-0.01404776331037283,
-0.011231109499931335,
0.018864477053284645,
-0.0184384286403656,
0.022982945665717125,
0.009526915848255157,
0.011379043571650982,
0.05036839097738266,
-0.016106996685266495,
-0.02325514331459999,
0.015822965651750565,
0.01919584907591343,
-0.03810766339302063,
-0.0099943857640028,
0.006887782830744982,
0.025610243901610374,
0.0003084413183387369,
-0.0032338257879018784,
-0.01301814615726471,
-0.009373065084218979,
-0.011728166602551937,
-0.055102262645959854,
0.04942161589860916,
-0.009876038879156113,
0.015385081991553307,
0.042746856808662415,
0.024095404893159866,
-0.005615554749965668,
0.019207682460546494,
0.041989438235759735,
0.026557018980383873,
-0.00608894182369113,
-0.00884050503373146,
0.03940948098897934,
-0.02242671512067318,
-0.011781422421336174,
0.010810978710651398,
0.002270778873935342,
-0.0032663713209331036,
-0.037870969623327255,
-0.01779935695230961,
-0.016840746626257896,
-0.016047824174165726,
0.010840564966201782,
-0.03268738090991974,
0.010917491279542446,
0.004917308688163757,
0.0044320872984826565,
0.05552831292152405,
0.00866298470646143,
-0.007171815261244774,
0.03436790779232979,
-0.0004260484129190445,
-0.01102400291711092,
0.009420404210686684,
-0.014675001613795757,
-0.01970474049448967,
-0.021278752014040947,
-0.03164593130350113,
-0.015574436634778976,
0.015361412428319454,
0.018710626289248466,
-0.05756387487053871,
-0.0216692965477705,
0.025633912533521652,
0.008296109735965729,
-0.007816805504262447,
-0.02242671512067318,
-0.015609940513968468,
0.01713661476969719,
-0.016047824174165726,
0.01736147329211235,
-0.013846573419868946,
-0.025491897016763687,
0.027669478207826614,
-0.0178348608314991,
-0.004488301929086447,
0.024119075387716293,
0.0019142592791467905,
0.015219396911561489,
-0.018580446019768715,
-0.0025725632440298796,
-0.010100898332893848,
0.0025296625681221485,
-0.026699034497141838,
0.026699034497141838,
-0.029752381145954132,
0.021787643432617188,
0.01427262183278799,
-0.004452797584235668,
-0.014568489044904709,
-0.013456029817461967,
-0.029728712514042854,
-0.0061185285449028015,
0.02445044554769993,
0.03176427632570267,
-0.021408934146165848,
0.022604236379265785,
0.006100776605308056,
0.027835164219141006,
-0.01116601936519146,
0.015160223469138145,
0.023645687848329544,
0.0354093573987484,
-0.002868430223315954,
-0.031054196879267693,
-0.010905656032264233,
0.019053831696510315,
-0.017905868589878082,
0.005662893410772085,
-0.00025315117090940475,
-0.002162787364795804,
-0.003085892414674163,
-0.011923438869416714,
0.02781149372458458,
-0.0013950127176940441,
0.008449960500001907,
-0.03157492354512215,
0.017728349193930626,
0.006645171903073788,
0.004423210863023996,
-0.007799053099006414,
0.017752017825841904,
0.01549159362912178,
0.01900649443268776,
0.008136341348290443,
-0.00839670468121767,
0.0049912757240235806,
-0.049658309668302536,
-0.0014948678435757756,
-0.0006102256011217833,
0.02461613155901432,
-0.03753960132598877,
-0.015609940513968468,
-0.022130848839879036,
0.0068108574487268925,
0.007793135941028595,
0.04407234117388725,
-0.009562419727444649,
0.013811069540679455,
-0.019302360713481903,
-0.0092192143201828,
0.0017071523470804095,
0.013621714897453785,
-0.00988195650279522,
-0.013456029817461967,
0.027030404657125473,
-0.032616373151540756,
0.014592158608138561,
0.012710444629192352,
0.0047723338939249516,
-0.0006960270111449063,
-0.008970686234533787,
0.004020832013338804,
-0.014947199262678623,
-0.02290010266005993,
0.0016997556667774916,
0.020130788907408714,
0.021550949662923813,
-0.03950415551662445,
0.04426169767975807,
0.01764550618827343,
-0.03436790779232979,
-0.01824907399713993,
-0.005304894410073757,
0.0032693298999220133,
-0.010124566964805126,
0.018544940277934074,
0.0005506823654286563,
0.0055267950519919395,
-0.016296351328492165,
-0.015101050026714802,
0.008390787057578564,
-0.017621835693717003,
-0.0066333371214568615,
0.007272409740835428,
-0.029515687376260757,
0.008106755092740059,
-0.020994719117879868,
-0.03725556656718254,
-0.005668811034411192,
0.010023972950875759,
-0.01945621147751808,
-0.008361199870705605,
-0.01634369045495987,
0.025870606303215027,
-0.002806298201903701,
-0.0006379631231538951,
-0.02901863120496273,
0.05647508427500725,
-0.0014852521708235145,
-0.0017589291092008352,
-0.004825590178370476,
0.013444194570183754,
0.035811737179756165,
-0.028332220390439034,
-0.01881713792681694,
-0.03259270265698433,
0.005615554749965668,
0.022343872115015984,
-0.005009027663618326,
0.03737391531467438,
0.05354008451104164,
-0.021373428404331207,
0.011645323596894741,
0.010876069776713848,
-0.014651332050561905,
0.028048187494277954,
0.013373186811804771,
0.0024379438254982233,
-0.012083206325769424,
0.009515081532299519,
-0.03190629184246063,
-0.010775474831461906,
-0.015065545216202736,
0.0034172635059803724,
-0.003716089064255357,
0.03789464011788368,
0.03301875293254852,
-0.02565758302807808,
0.013467864133417606,
0.02622564695775509,
0.00007438280590577051,
-0.008106755092740059,
-0.0026583645958453417,
-0.0001791844260878861,
-0.00871032290160656,
0.004582979250699282,
-0.007870061323046684,
-0.012343569658696651,
-0.00987012218683958,
0.038344357162714005,
0.05226194113492966,
0.0215391144156456,
0.005810827016830444,
-0.016935424879193306,
-0.030841171741485596,
0.003307792590931058,
-0.014130606316030025,
-0.038320690393447876,
0.0004197612579446286,
0.0115447286516428,
-0.0013972317101433873,
-0.02327881194651127,
-0.006017934065312147,
-0.020616009831428528,
-0.01904199831187725,
0.027882501482963562,
-0.00006744841812178493,
0.020888207480311394,
0.0277878250926733,
0.006319718435406685,
-0.009645262733101845,
0.039835527539253235,
-0.027172422036528587,
-0.018828973174095154,
-0.014438307844102383,
-0.01479334756731987,
-0.012035868130624294,
0.011953025124967098,
-0.01210095826536417,
-0.014284457080066204,
-0.04527948051691055,
-0.04717302694916725,
0.03772895410656929,
-0.0000026206184884358663,
0.018178066238760948,
0.026557018980383873,
0.011118680238723755,
0.0019630773458629847,
-0.025610243901610374,
0.015657279640436172,
-0.008367117494344711,
0.02582326903939247,
0.023042118176817894,
-0.010745887644588947,
0.0193852037191391,
-0.004408417735248804,
-0.00486405286937952,
-0.0013735623797401786,
0.00933164358139038,
0.02189415507018566,
-0.0270540751516819,
0.026509679853916168,
0.00019138894276693463,
-0.0076096984557807446,
0.00025629476294852793,
-0.0038048492278903723,
-0.0452321395277977,
0.015006371773779392,
0.016970928758382797,
-0.001478595077060163,
0.018071554601192474,
0.02214268408715725,
-0.030367784202098846,
0.0022086468525230885,
0.037302907556295395,
0.028521575033664703,
-0.0019290526397526264,
-0.0002010046155191958,
0.026438672095537186,
0.026699034497141838,
0.005855207331478596,
-0.025207864120602608,
0.03053347021341324,
0.008905595168471336,
-0.012958972714841366,
-0.005100746173411608,
-0.02046215906739235,
0.004142137244343758,
0.002213084837421775,
0.05055774748325348,
0.017728349193930626,
-0.010728135704994202,
-0.0053847786039114,
0.013740061782300472,
-0.03652181848883629,
0.01798871159553528,
-0.0034823541063815355,
-0.01301814615726471,
0.010018055327236652,
0.010739970952272415,
0.006219123490154743,
0.013882078230381012,
0.004272318910807371,
0.011308034881949425,
0.012343569658696651,
0.04326758533716202,
-0.003571114270016551,
0.0070120468735694885,
0.01932602934539318,
0.014828852377831936,
0.041137341409921646,
-0.007775383535772562,
-0.0021997708827257156,
0.030107421800494194,
0.00005547505497816019,
-0.0026036291383206844,
0.007337500806897879,
0.043598953634500504,
-0.015941312536597252,
0.02471080794930458,
-0.03237967938184738,
0.021752139553427696,
-0.03287673741579056,
0.0292079858481884,
0.07981307059526443,
-0.03032044693827629,
-0.011852430179715157,
0.018107058480381966,
-0.004648069851100445,
-0.013491533696651459,
0.010000303387641907,
-0.0044320872984826565,
0.011018085293471813,
0.00505340751260519,
0.001782598439604044,
0.012852461077272892,
0.03597742319107056,
0.012911634519696236,
0.0270540751516819,
-0.020036110654473305,
0.015373247675597668,
0.047883108258247375,
-0.014959033578634262,
-0.026557018980383873,
0.017065607011318207,
0.008698488585650921,
0.0006224301178008318,
0.017976876348257065,
-0.005796033889055252,
-0.010917491279542446,
-0.014840686693787575,
-0.062487103044986725,
0.0036953783128410578,
-0.0014778554905205965,
0.007396673783659935,
0.017882199957966805,
0.01581113040447235,
-0.05822661891579628,
0.03133822977542877,
-0.00176040839869529,
-0.003180569736286998,
-0.04054560884833336,
-0.009290223009884357,
0.013290343806147575,
0.0385100431740284,
0.01609516330063343,
0.013515202328562737,
0.014663166366517544,
0.029989074915647507,
0.01198852900415659,
-0.025681251659989357,
-0.017811190336942673,
0.02854524366557598,
-0.014438307844102383,
-0.001474896795116365,
0.013775565661489964,
0.02316046506166458,
-0.011929355561733246,
-0.034225888550281525,
-0.02527887374162674,
0.020012442022562027,
0.0022855722345411777,
-0.0004744966281577945,
-0.034225888550281525,
0.017823025584220886,
0.015373247675597668,
0.02407173626124859,
-0.03884141519665718,
-0.01301814615726471
] | 2024-07-22 | 1 | 39037052 | [
"T cells",
"primary human T cells",
"cancer cell lines",
"human tumors",
"tumor evasion mechanisms",
"Siglec-9 CSRs",
"tumor hypersialylation",
"specific Siglec-9 CSRs",
"engineered T cell-based cancer treatment",
"immunosuppressive molecules",
"costimulatory molecules",
"different mechanisms",
"Siglec-9",
"increased cytokine secretions",
"T-cell immunosurveillance",
"robust antitumor activity",
"sialic acid moieties",
"checkpoint ligands",
"Cancer",
"cancer-specific T-cell activity",
"related Spotlight",
"different hinge regions",
"several Siglec-9-based chimeric switch receptors",
"α2,6 hypersialylation",
"secretion",
"the Siglec-9+ T-cell population",
"CRISPR)/Cas9 system",
"reduced effector function",
"sialylated residues",
"Abken"
] | [] | 0 | 10.1158/2326-6066.CIR-23-0823 | [
"Eisenberg",
"Hoogi",
"Katzman",
"Ben Haim",
"Zur-Toledano",
"Radman",
"Reboh",
"Zadok",
"Kamer",
"Bar",
"Sagi",
"Hendel",
"Cohen"
] | [
"Laboratory of Tumor Immunology and Immunotherapy, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.",
"Laboratory of Tumor Immunology and Immunotherapy, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.",
"Laboratory of Tumor Immunology and Immunotherapy, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.",
"Institute of Nanotechnology and Advanced Materials, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.",
"Laboratory of Tumor Immunology and Immunotherapy, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.",
"Laboratory of Tumor Immunology and Immunotherapy, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.",
"Laboratory of Tumor Immunology and Immunotherapy, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.",
"Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel.",
"Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel.",
"Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel.\nSchool of Medicine, Tel Aviv University, Tel Aviv, Israel.",
"Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.",
"Institute of Nanotechnology and Advanced Materials, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.",
"Laboratory of Tumor Immunology and Immunotherapy, The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel."
] | [
"39037052"
] | [] | 10.565889 | 4.841741 |
39034731 | 703 | FDA-approved CAR T-cell Therapy: A Decade of Progress and Challenges. | CAR T-cell therapy is a promising approach for cancer treatment, utilizing a patient's own T-cells (autologous cell) or T-cells from a healthy donor (allogeneic cell) to target and destroy cancer cells. Over the last decade, significant advancements have been made in this field, including the development of novel CAR constructs, improved understanding of biology and mechanisms of action, and expanded clinical applications for treating a wider range of cancers. In this review, we provide an overview of the steps involved in the production of CAR T-cells and their mechanism of action. We also introduce different CAR T-cell therapies available, including their implementation, dosage, administration, treatment cost, efficacy, and resistance. Common side effects of CAR T-cell therapy are also discussed. The CAR T-cell products highlighted in this review are FDA-approved products, which include Kymriah | [
-0.003167439252138138,
0.009027735330164433,
0.03975829482078552,
0.061599764972925186,
-0.02768576703965664,
-0.03498047590255737,
-0.0019196602515876293,
0.01774619147181511,
0.023611821234226227,
0.0003709343436639756,
0.0060256002470850945,
-0.03758268058300018,
-0.04295773059129715,
-0.009081059135496616,
0.020583024248480797,
-0.04496270790696144,
0.03779597580432892,
0.0033327434211969376,
0.026747265830636024,
0.001944989082403481,
0.03216497227549553,
0.013554934412240982,
0.004687170498073101,
-0.001951654558070004,
-0.01287238858640194,
-0.02033773437142372,
0.01997513137757778,
-0.001537061296403408,
-0.0487167090177536,
-0.05882691964507103,
-0.018919317051768303,
-0.020913630723953247,
-0.009976901113986969,
-0.04039818421006203,
0.02459298074245453,
0.031034506857395172,
0.035407066345214844,
-0.007236052770167589,
-0.01744757778942585,
-0.0069374386221170425,
0.02847496047616005,
0.03163173422217369,
0.01754356175661087,
0.0737576112151146,
-0.06851053982973099,
-0.021670831367373466,
0.007918598130345345,
-0.04457877576351166,
-0.02228938788175583,
-0.009859587997198105,
-0.024145059287548065,
-0.015783872455358505,
-0.02363315038383007,
0.05396378040313721,
-0.06808394938707352,
0.04927127808332443,
-0.036388225853443146,
0.002310257637873292,
0.0020103107672184706,
0.016466418281197548,
-0.020156431943178177,
0.005503025837242603,
0.015485258772969246,
-0.006617495324462652,
-0.05763246491551399,
-0.003666017670184374,
-0.054262395948171616,
-0.024742286652326584,
-0.015410605818033218,
0.06130114942789078,
0.030159994959831238,
-0.014024184085428715,
0.011784580536186695,
0.004841809626668692,
0.040312863886356354,
-0.013160337693989277,
-0.022758638486266136,
0.017650209367275238,
0.0306079164147377,
0.0002362915111007169,
0.057461827993392944,
-0.007646646350622177,
-0.02350517362356186,
-0.047650232911109924,
0.004380558151751757,
-0.020583024248480797,
0.00255954684689641,
-0.020028455182909966,
-0.01675436832010746,
-0.020039118826389313,
-0.018482061102986336,
0.024081071838736534,
-0.02205476351082325,
0.04210454598069191,
-0.004668506793677807,
0.02945611998438835,
-0.0289655402302742,
-0.04483472928404808,
0.02636333368718624,
0.0388411246240139,
0.05477430671453476,
0.022076092660427094,
-0.018844664096832275,
-0.006249560508877039,
0.05567014589905739,
0.005260402336716652,
-0.061642423272132874,
0.02824033424258232,
0.04035552218556404,
-0.013736234977841377,
0.025766106322407722,
-0.0048684715293347836,
0.002555547747761011,
0.044322822242975235,
-0.018940648064017296,
-0.07653045654296875,
0.00819588266313076,
-0.007348032668232918,
0.006638824939727783,
0.017628880217671394,
-0.031546417623758316,
0.061898376792669296,
0.009923577308654785,
-0.014162826351821423,
-0.009944906458258629,
-0.029157506301999092,
0.06462856382131577,
-0.009102389216423035,
-0.019164608791470528,
-0.04709566384553909,
0.03707077354192734,
0.005988273303955793,
0.011070040985941887,
-0.0015317288925871253,
-0.07247783988714218,
0.011432643048465252,
-0.009107721038162708,
0.004625848028808832,
-0.01599716767668724,
-0.02538217417895794,
0.010702106170356274,
-0.044024206697940826,
0.004961788654327393,
0.02416638843715191,
-0.0209029670804739,
-0.05869894474744797,
-0.001405084622092545,
0.037838634103536606,
-0.008238541893661022,
0.03896910324692726,
-0.051958803087472916,
0.034383248537778854,
0.06424462795257568,
0.01463207695633173,
-0.023825116455554962,
-0.036452215164899826,
0.005063103977590799,
0.057163216173648834,
-0.03370070084929466,
-0.032079655677080154,
-0.030309302732348442,
0.010062218643724918,
-0.03235694020986557,
-0.044920049607753754,
-0.03581232950091362,
-0.006297552026808262,
-0.020732330158352852,
-0.001279773423448205,
-0.04097408056259155,
0.03574834018945694,
-0.02442234382033348,
-0.06223965063691139,
-0.07234986126422882,
0.022929275408387184,
-0.02781374379992485,
-0.005625670775771141,
0.016402430832386017,
0.055286213755607605,
-0.02248135395348072,
-0.04530398175120354,
0.01056879572570324,
-0.002130289562046528,
0.008937085047364235,
-0.007326703052967787,
-0.027771083638072014,
0.019249925389885902,
-0.012499121017754078,
0.026086049154400826,
-0.07021690160036087,
-0.018247436732053757,
0.019548539072275162,
-0.009843590669333935,
0.013490945100784302,
-0.012680422514677048,
-0.006217566318809986,
-0.0029221493750810623,
0.03466053307056427,
0.023953093215823174,
-0.031247802078723907,
-0.026747265830636024,
0.042467150837183,
-0.056736625730991364,
-0.06334878504276276,
0.020199092105031013,
-0.04059014841914177,
-0.0338926687836647,
-0.026640618219971657,
0.057163216173648834,
-0.03018132410943508,
-0.0022236064542084932,
0.014205485582351685,
-0.016861015930771828,
-0.02696056105196476,
0.0473942793905735,
-0.040995411574840546,
-0.014888031408190727,
-0.021009614691138268,
0.048802029341459274,
0.010963392443954945,
0.02725917473435402,
-0.01872735284268856,
0.01593318022787571,
0.00028844893677160144,
0.002063634805381298,
-0.03440457582473755,
-0.008531822822988033,
0.022374706342816353,
-0.02011377364397049,
-0.008745118975639343,
-0.0414859913289547,
-0.009896914474666119,
0.024806275963783264,
0.04743693768978119,
-0.02050836943089962,
-0.031247802078723907,
-0.03837187588214874,
0.0049244617111980915,
-0.017426248639822006,
0.04683971032500267,
-0.01830076053738594,
0.022012103348970413,
0.010360833257436752,
0.004492538049817085,
-0.023249218240380287,
-0.026939231902360916,
-0.0015263964887708426,
-0.0020303071942180395,
-0.07269113510847092,
0.03933170437812805,
-0.01557057723402977,
-0.01763954386115074,
0.024998242035508156,
-0.0002641199098434299,
0.009544976986944675,
0.041528649628162384,
0.024273037910461426,
0.042467150837183,
-0.03617493063211441,
0.029584096744656563,
-0.01120868232101202,
-0.01075009722262621,
-0.0032447590492665768,
-0.041464660316705704,
-0.06770001351833344,
-0.06799863278865814,
0.052684009075164795,
-0.027963049709796906,
-0.0039299712516367435,
0.019697846844792366,
-0.01031817402690649,
0.024145059287548065,
0.013949531130492687,
0.05682194232940674,
-0.014717395417392254,
-0.04803416505455971,
0.026576628908514977,
0.004636512603610754,
0.034191280603408813,
0.022140081971883774,
0.02405974082648754,
0.02063634805381298,
0.0035487052518874407,
-0.0017730195540934801,
-0.028794903308153152,
0.005732318852096796,
-0.022438695654273033,
0.018119459971785545,
0.01202987041324377,
-0.012616433203220367,
-0.027771083638072014,
0.0464131198823452,
0.0026048722211271524,
-0.009091723710298538,
-0.026086049154400826,
0.010515471920371056,
0.01711696945130825,
-0.018290096893906593,
-0.03005334734916687,
-0.013384297490119934,
0.027856402099132538,
-0.05665130540728569,
0.04726630076766014,
-0.010952727869153023,
-0.04289374127984047,
0.02574477717280388,
0.02241736464202404,
-0.00674014026299119,
-0.023611821234226227,
0.04193391278386116,
0.02531818486750126,
0.0209029670804739,
0.01377889420837164,
0.04513334482908249,
0.02551015093922615,
0.021542852744460106,
0.03143977001309395,
0.009742275811731815,
-0.08135093748569489,
0.027408482506871223,
-0.05665130540728569,
-0.026320675387978554,
-0.017682204023003578,
-0.014226814731955528,
0.031909018754959106,
-0.00036493540392257273,
-0.04999648407101631,
0.01853538677096367,
-0.006334878504276276,
0.01793815754354,
-0.022950604557991028,
-0.0006905444315634668,
-0.043768253177404404,
0.05349453166127205,
-0.01997513137757778,
0.005503025837242603,
-0.0054150414653122425,
-0.019900478422641754,
-0.04999648407101631,
0.015815867111086845,
-0.007923930883407593,
-0.005185748916119337,
0.031909018754959106,
-0.0398222841322422,
0.05835767090320587,
-0.019335243850946426,
-0.015879856422543526,
0.008633138611912727,
0.0444507971405983,
-0.016797026619315147,
0.0034473896957933903,
0.0059776087291538715,
0.004431215580552816,
0.00949698593467474,
-0.006457523908466101,
-0.015495924279093742,
0.06283687800168991,
-0.06475653499364853,
0.008723788894712925,
0.02327054738998413,
0.0011917890515178442,
0.03896910324692726,
0.01692500337958336,
-0.017788851633667946,
0.04332033172249794,
0.04824746027588844,
0.08207613974809647,
-0.038862455636262894,
0.04615716263651848,
-0.03314613178372383,
-0.04683971032500267,
-0.006174907088279724,
-0.02508356049656868,
0.011187353171408176,
0.004495204426348209,
-0.010696773417294025,
0.020263079553842545,
0.014589417725801468,
0.02393176406621933,
0.005508358124643564,
0.0021689494606107473,
0.03342341631650925,
-0.02484893426299095,
-0.009891582652926445,
-0.005780310370028019,
-0.011987211182713509,
0.031845029443502426,
0.006324213929474354,
0.012488456442952156,
-0.048802029341459274,
0.03736938536167145,
0.0048258122988045216,
-0.00580163998529315,
-0.01153929065912962,
-0.010840747505426407,
-0.029605425894260406,
0.06927840411663055,
-0.032570235431194305,
0.08732321113348007,
0.04067546874284744,
0.01056879572570324,
0.014312133193016052,
-0.03907575085759163,
-0.017799515277147293,
-0.031247802078723907,
0.016146475449204445,
-0.020817648619413376,
0.02452899143099785,
0.01869535818696022,
0.01929258555173874,
-0.0016517076874151826,
0.0164557546377182,
0.006601497996598482,
0.03564169257879257,
0.012904382310807705,
0.007993252016603947,
-0.017234282568097115,
-0.038329217582941055,
0.05626737326383591,
-0.011485966853797436,
-0.010222190991044044,
0.025979401543736458,
-0.006457523908466101,
-0.004188592080026865,
-0.02047637477517128,
0.004697835072875023,
0.022993262857198715,
0.03182370215654373,
0.03071456402540207,
-0.03736938536167145,
-0.02241736464202404,
0.0009258361533284187,
0.04696768522262573,
-0.01333097368478775,
-0.016146475449204445,
0.003895310452207923,
0.015954509377479553,
-0.0404835008084774,
-0.004588521085679531,
-0.044322822242975235,
0.03628157824277878,
-0.04178460314869881,
0.0017596884863451123,
0.01681835576891899,
-0.014472105540335178,
0.04594386741518974,
0.013096348382532597,
0.03271954134106636,
0.005271066911518574,
-0.04157130792737007,
-0.030799882486462593,
-0.030159994959831238,
0.0002712853020057082,
-0.03525776043534279,
-0.008467834442853928,
-0.04163529723882675,
0.0008531823405064642,
-0.008403846062719822,
-0.05912553519010544,
-0.008553152903914452,
0.04581588879227638,
0.03798794373869896,
-0.04846075549721718,
0.024870265275239944,
-0.013960195705294609,
-0.02580876462161541,
0.04385356977581978,
0.044322822242975235,
-0.0013664248399436474,
-0.012307154946029186,
-0.0654817447066307,
0.03736938536167145,
-0.016103817149996758,
-0.03954499959945679,
-0.013864212669432163,
-0.014973349869251251,
0.026875242590904236,
0.008953082375228405,
-0.0038446527905762196,
0.010019559413194656,
-0.005860296078026295,
-0.02369713969528675,
0.018023476004600525,
-0.032143644988536835,
0.003066123928874731,
0.014429446309804916,
0.013192331418395042,
-0.015613236464560032,
0.00919837225228548,
-0.01948455162346363,
0.01232848409563303,
-0.022396035492420197,
0.0033594053238630295,
0.03485249727964401,
-0.006782799493521452,
-0.020295074209570885,
-0.01908995397388935,
-0.009768937714397907,
0.0031327789183706045,
-0.026214025914669037,
0.005127092357724905,
-0.022566672414541245,
0.02617136761546135,
-0.009544976986944675,
0.02841097116470337,
0.02478494681417942,
0.060917217284440994,
0.005609673913568258,
0.06488451361656189,
-0.015069332905113697,
0.007913266308605671,
-0.03792395442724228,
-0.0022529345005750656,
0.0365375317633152,
-0.02610737830400467,
-0.031951677054166794,
-0.0112726716324687,
-0.056864600628614426,
-0.007182728499174118,
-0.0012624432565644383,
-0.014066843315958977,
-0.017106305807828903,
-0.013426956720650196,
-0.009592968970537186,
-0.01384288351982832,
0.020103108137845993,
-0.021777478978037834,
-0.034873828291893005,
0.013192331418395042,
-0.02834698185324669,
-0.018738016486167908,
0.004111272282898426,
-0.006100253667682409,
0.0116032799705863,
0.017372924834489822,
-0.018023476004600525,
-0.028922880068421364,
-0.026576628908514977,
0.04624248296022415,
-0.029733404517173767,
-0.016007833182811737,
-0.010931398719549179,
-0.018055470660328865,
0.032079655677080154,
-0.014738724566996098,
-0.012072529643774033,
0.022758638486266136,
-0.0021289566066116095,
-0.024315696209669113,
0.009832926094532013,
0.0028821565210819244,
0.04786352813243866,
-0.01899397186934948,
-0.013490945100784302,
-0.01836474984884262,
0.005519023165106773,
-0.017884833738207817,
-0.008905090391635895,
-0.04573057219386101,
-0.009107721038162708,
-0.03282618895173073,
-0.005247071385383606,
-0.019281920045614243,
0.0064521911554038525,
-0.016509078443050385,
-0.010835415683686733,
0.042445819824934006,
-0.005593676585704088,
-0.03672949969768524,
-0.021830802783370018,
0.014237480238080025,
0.005822969134896994,
0.008761116303503513,
0.02109493315219879,
-0.029285483062267303,
0.018770011141896248,
0.01138998381793499,
0.018428737297654152,
0.020252415910363197,
-0.013896207325160503,
0.05251337215304375,
-0.03630290925502777,
-0.02033773437142372,
-0.014205485582351685,
0.03549238294363022,
0.014728059992194176,
0.016381099820137024,
-0.05059371143579483,
-0.018226107582449913,
-0.008302530273795128,
-0.0015064000617712736,
0.039097078144550323,
0.027109868824481964,
0.03233560919761658,
0.0019223263952881098,
-0.038862455636262894,
0.029434790834784508,
-0.0013364300830289721,
0.012595104053616524,
-0.019676517695188522,
-0.009075727313756943,
-0.019335243850946426,
-0.002962142461910844,
-0.031951677054166794,
-0.0361962616443634,
-0.029178835451602936,
0.028688255697488785,
-0.017927493900060654,
0.0059829410165548325,
0.00870779249817133,
0.0015050669899210334,
0.036558862775564194,
0.0001459741615690291,
-0.03246358782052994,
0.010787423700094223,
0.03773198649287224,
0.011027381755411625,
-0.02824033424258232,
-0.002839497523382306,
-0.02290794439613819,
-0.008222544565796852,
-0.0036446882877498865,
-0.00919837225228548,
-0.012819064781069756,
0.0032900844234973192,
-0.004236583597958088,
-0.028091028332710266,
-0.009102389216423035,
0.0007245384040288627,
-0.0043565621599555016,
-0.0012137851445004344,
-0.0112726716324687,
-0.017362259328365326,
-0.001253111520782113,
0.038201238960027695,
-0.0004579189408104867,
-0.035236429423093796,
0.05434771254658699,
-0.02129756286740303,
0.022993262857198715,
0.005519023165106773,
-0.047053005546331406,
-0.0006122249760665,
0.0029914705082774162,
-0.014525429345667362,
0.017063645645976067,
0.016711708158254623,
-0.012776405550539494,
0.00837718416005373,
0.005886957980692387,
-0.011262007057666779,
0.0012724414700642228,
-0.02008177898824215,
0.021084267646074295,
-0.047778211534023285,
0.009081059135496616,
-0.005252403672784567,
0.002699522068724036,
0.01665838435292244,
0.08075370639562607,
0.056864600628614426,
-0.034383248537778854,
0.027173856273293495,
-0.0054577006958425045,
-0.025723446160554886,
-0.0082278773188591,
-0.005503025837242603,
0.018012812361121178,
-0.0027248510159552097,
0.0019503214862197638,
-0.005039107985794544,
0.04854607582092285,
0.019111283123493195,
-0.015016009099781513,
-0.015911851078271866,
-0.02031640335917473,
-0.0017836842453107238,
0.007172063924372196,
-0.030330631881952286,
-0.010952727869153023,
0.029370801523327827,
-0.0031941013876348734,
0.004497870337218046,
-0.031482428312301636,
-0.008729121647775173,
-0.006617495324462652,
-0.018343420699238777,
0.019345909357070923,
0.033060815185308456,
0.008419843390583992,
-0.01635977067053318,
0.013234990648925304,
-0.03495914489030838,
-0.03736938536167145,
0.012115188874304295,
0.008926420472562313,
0.02093496173620224,
0.006057594437152147,
-0.018716687336564064,
-0.004511201288551092,
-0.008665133267641068,
0.03152508661150932,
0.029584096744656563,
0.014034849591553211,
-0.012168512679636478,
0.035897646099328995,
-0.0043752253986895084,
-0.02452899143099785,
-0.02617136761546135,
0.001715696300379932,
0.01833275519311428,
0.02224672958254814,
-0.030202653259038925,
-0.018674027174711227,
-0.026875242590904236,
-0.01008888054639101,
0.007012092042714357,
-0.004148599226027727,
0.03587631508708,
0.0022609331645071507,
0.015357282012701035,
0.004713832400739193,
0.04875937104225159,
-0.014984014444053173,
0.01073409989476204,
0.02580876462161541,
0.03815858066082001,
-0.0395023413002491,
0.05840032920241356,
-0.02339852601289749,
-0.009257027879357338,
-0.0036980120930820704,
-0.027899062260985374,
-0.01777818612754345,
0.006036264821887016,
-0.03331676870584488,
-0.006697481032460928,
-0.024614309892058372,
-0.029904039576649666,
-0.03643088415265083,
-0.005223075393587351,
0.033658042550086975,
-0.005265734624117613,
-0.022609330713748932,
0.009251696057617664,
-0.019580533728003502,
0.004940459039062262,
0.010296843945980072,
-0.007641314063221216,
0.0026941897813230753,
-0.04046216979622841,
0.010334170423448086,
0.004804483149200678,
-0.0092996871098876,
-0.019729841500520706,
0.004596519749611616,
-0.03973696753382683,
0.01814078912138939,
-0.0054577006958425045,
-0.026789924129843712,
0.004055282101035118,
-0.03436191752552986,
0.0015957175055518746,
0.010499474592506886,
0.00903306808322668,
-0.004535197280347347,
-0.004268577788025141,
0.029776062816381454,
0.048204801976680756,
-0.005710989236831665,
0.02653397060930729,
-0.0361962616443634,
-0.0064895180985331535,
0.008249206468462944,
-0.02715252712368965,
-0.019953802227973938,
-0.0020676341373473406,
-0.01580520160496235,
0.023483842611312866,
0.0016023830976337194,
0.0032340942416340113,
-0.0021476198453456163,
-0.002014310099184513,
-0.025339514017105103,
0.01586919091641903,
0.019495215266942978,
-0.02162817120552063,
0.0017250280361622572,
0.006660154554992914,
-0.045048028230667114,
0.002954143797978759,
-0.0011098035611212254,
0.017330266535282135,
-0.033295441418886185,
0.011048710905015469,
-0.013202995993196964,
0.018716687336564064,
0.03167439252138138,
-0.03485249727964401,
-0.008521158248186111,
0.0037886628415435553,
-0.01833275519311428,
-0.009289022535085678,
0.0075773256830871105,
-0.03090653009712696,
-0.013309644535183907,
0.010499474592506886,
-0.03824389725923538,
0.01366158202290535,
-0.010835415683686733,
-0.004652509931474924,
-0.002091629896312952,
-0.027963049709796906,
-0.005764313042163849,
-0.053835805505514145,
-0.07482408732175827,
-0.01318166684359312,
0.04120870679616928,
0.016509078443050385,
-0.004393889103084803,
-0.0010911402059718966,
0.03828655555844307,
0.010046222247183323,
-0.004735162016004324,
0.00011389650899218395,
-0.04184859246015549,
-0.038499850779771805,
0.006078924052417278,
-0.006372205447405577,
0.013608258217573166,
-0.05618205666542053,
0.02478494681417942,
-0.008505160920321941,
0.004852474667131901,
0.02077499032020569,
0.0023275879211723804,
-0.004876470193266869,
-0.0005888957530260086,
-0.012381808832287788,
0.011347324587404728,
0.02423037774860859,
0.010350167751312256,
-0.018492726609110832,
-0.0021956113632768393,
-0.024145059287548065,
0.00041259362478740513,
0.006158909760415554,
-0.017266277223825455,
0.011923222802579403,
-0.0381799079477787,
-0.023846445605158806,
-0.011656603775918484,
0.015367946587502956,
0.01348028052598238,
-0.01109137013554573,
0.014472105540335178,
0.003836654359474778,
0.01224316656589508,
-0.020551029592752457,
0.04671173170208931,
0.04024887457489967,
-0.018652698025107384,
-0.016039827838540077,
-0.029904039576649666,
-0.05567014589905739,
0.03628157824277878,
-0.03542839735746384,
0.006014935206621885,
-0.011869898997247219,
0.005340388044714928,
-0.030693234875798225,
0.019409898668527603,
-0.009241030551493168,
-0.0025088891852647066,
-0.010355500504374504,
-0.008067904971539974,
0.012648427858948708,
0.007731964811682701,
-0.043043047189712524,
-0.03715609014034271,
-0.019303249195218086,
0.005252403672784567,
-0.03604695200920105,
-0.014013519510626793,
-0.01623179391026497,
0.01672237366437912,
0.02228938788175583,
-0.01120868232101202,
0.0007985253469087183,
-0.022502683103084564,
-0.0060895886272192,
-0.009507650509476662,
-0.024976912885904312,
-0.011048710905015469,
-0.023014593869447708,
0.01672237366437912,
0.015111992135643959,
-0.01616780459880829,
0.0338926687836647,
-0.007875938899815083,
0.01269108708947897,
-0.023953093215823174,
-0.030266642570495605,
-0.028794903308153152,
0.023249218240380287,
-0.0004345897468738258,
0.01694633439183235,
-0.04084610193967819,
0.02913617715239525,
-0.04084610193967819,
0.003988627344369888,
-0.02913617715239525,
-0.017404919490218163,
0.02672593668103218,
0.03271954134106636,
0.012488456442952156,
0.005908287595957518,
0.0032500913366675377,
0.05106296017765999,
0.021649502217769623,
-0.02139354683458805,
-0.029541438445448875,
-0.018279431387782097,
-0.022012103348970413,
-0.004575190134346485,
0.025254197418689728,
0.002358249155804515,
0.003953966777771711,
0.025723446160554886,
-0.00468183821067214,
0.02508356049656868,
0.013864212669432163,
-0.0008658467559143901,
0.04829011857509613,
0.019004635512828827,
0.03623891994357109,
0.004772488493472338,
0.023675808683037758,
-0.010776759125292301,
0.0029381467029452324,
-0.012435132637619972,
-0.008713124319911003,
0.05187348648905754,
0.0006028932984918356,
-0.031951677054166794,
0.03071456402540207,
0.01962319388985634,
0.023462513461709023,
-0.034873828291893005,
0.025531480088829994,
0.045048028230667114,
0.04289374127984047,
0.012637763284146786,
0.00831319484859705,
0.015549248084425926,
-0.0002849495504051447,
0.002402241574600339,
0.017863504588603973,
-0.0582723543047905,
0.040014252066612244,
-0.02004978433251381,
-0.019548539072275162,
0.0011584616731852293,
-0.006196236703544855,
-0.0008478499366901815,
0.007977254688739777,
0.044621434062719345,
0.010430153459310532,
0.019505880773067474,
-0.01632777601480484,
0.03340208902955055,
-0.013075019232928753,
0.0083931814879179,
0.019303249195218086,
0.022396035492420197,
0.012808399274945259,
0.01351227518171072,
0.04061147943139076,
-0.025104889646172523,
-0.012136518955230713,
0.018887324258685112,
0.035471055656671524,
0.015911851078271866,
-0.043299004435539246,
0.00211562542244792,
-0.0605759434401989,
-0.03412729129195213,
0.009209036827087402,
-0.000057823097449727356,
-0.021404212340712547,
0.00847849901765585,
0.05029509961605072,
0.0027088539209216833,
-0.032015666365623474,
-0.026086049154400826,
0.015293292701244354,
-0.014397451654076576,
0.010408824309706688,
-0.03713475912809372,
0.027408482506871223,
0.05421973764896393,
-0.016583731397986412,
0.015079997479915619,
0.009528979659080505,
0.010371497832238674,
-0.03374335914850235,
0.009934241883456707,
0.04110205918550491,
0.0037620007060468197,
0.054987601935863495,
-0.02218274027109146,
0.017394253984093666,
-0.00724138505756855,
-0.0059136198833584785,
0.001253111520782113,
0.0036233586724847555,
-0.023014593869447708,
-0.012829729355871677,
-0.04816214367747307,
-0.05477430671453476,
-0.012477791868150234,
-0.023590490221977234,
0.006484185811132193,
0.0059189521707594395,
0.04897266626358032,
0.02653397060930729,
0.0018090131925418973,
0.007587990257889032,
-0.018226107582449913,
0.0202417504042387,
0.013522939756512642,
-0.020860306918621063,
0.01463207695633173,
0.023313207551836967,
-0.003967297729104757,
-0.03534307703375816,
0.007438683416694403,
-0.03175971284508705,
0.04300038889050484,
0.045474618673324585,
0.015325287356972694,
-0.0332527793943882,
-0.024699628353118896,
0.006361540872603655,
0.03640955686569214,
-0.0014490768080577254,
-0.0006965433713048697,
-0.006761469878256321,
-0.022140081971883774,
0.021969445049762726,
0.03427660092711449,
0.04598652571439743,
0.04302171990275383,
0.021969445049762726,
-0.0028128353878855705,
0.013192331418395042,
-0.01787417009472847,
0.01239247340708971,
-0.017063645645976067,
0.01919660158455372,
-0.010974057950079441,
-0.010515471920371056,
0.03346607834100723,
0.006057594437152147,
0.019068624824285507,
-0.03120514377951622,
-0.004233917221426964,
0.01879134029150009,
0.00804657582193613,
0.02913617715239525,
0.001418415573425591,
0.00029661416192539036,
0.006766802165657282,
-0.007635981775820255,
0.010824751108884811,
-0.012765740044414997,
-0.024209048599004745,
-0.0033274111337959766,
-0.004964454565197229,
-0.014461440034210682,
-0.04218986630439758,
0.018322089686989784,
0.01091006863862276,
0.021041609346866608,
-0.012008541263639927,
-0.007939928211271763,
-0.011613944545388222,
-0.017255611717700958,
-0.012968371622264385,
0.004185925703495741,
-0.025851424783468246,
-0.010110210627317429,
-0.016743702813982964,
-0.031845029443502426,
0.007689305581152439,
-0.0008771780994720757,
-0.00386331626214087,
-0.005124426446855068,
0.03606828302145004,
0.03781730681657791,
-0.013064354658126831,
-0.0034553883597254753,
0.03440457582473755,
-0.0032287619542330503,
-0.021041609346866608,
-0.04035552218556404,
0.0730750635266304,
-0.010264850221574306,
-0.06151444464921951,
-0.017884833738207817,
0.020785653963685036,
-0.0044338819570839405,
0.03630290925502777,
0.0025008907541632652,
-0.02109493315219879,
0.019303249195218086,
0.005737651139497757,
0.02452899143099785,
0.0039646318182349205,
-0.002130289562046528,
0.01015286985784769,
-0.013949531130492687,
-0.013768229633569717,
-0.007705302909016609,
0.006857452914118767,
-0.005652332678437233,
-0.016285117715597153,
-0.022161411121487617,
0.015058668330311775,
-0.006366873160004616,
-0.003364737844094634,
-0.0035753671545535326,
0.02380378730595112,
-0.008867763914167881,
0.0004939125501550734,
0.0070707486011087894,
0.010942063294351101,
0.004631180316209793,
-0.004588521085679531,
0.001515731681138277,
0.015175980515778065,
0.011507296934723854,
0.014493434689939022,
-0.026747265830636024,
-0.009555641561746597,
-0.0048951334320008755,
-0.003674016334116459,
-0.020007126033306122,
0.03672949969768524,
-0.016477083787322044,
-0.04743693768978119,
0.04500536620616913,
0.014280139468610287,
-0.0021822804119437933,
0.00919837225228548,
0.0034153955057263374,
-0.005065769888460636,
0.010051554068922997,
-0.00039559663855470717,
0.0007365362835116684,
0.033060815185308456,
0.000004561692549032159,
-0.005476363934576511,
0.026704607531428337,
-0.021276233717799187,
-0.014642741531133652,
-0.013970860280096531,
0.006542841903865337,
0.025403503328561783,
0.010744764469563961,
-0.04385356977581978,
-0.0043778917752206326,
0.020913630723953247,
0.007641314063221216,
0.05626737326383591,
0.025958072394132614,
-0.01692500337958336,
0.03186636045575142,
0.030799882486462593,
-0.002338252728804946,
-0.006852120626717806,
-0.023313207551836967,
0.004537863656878471,
-0.026022059842944145,
-0.01984715461730957,
-0.031887687742710114,
-0.002270264783874154,
0.00033077478292398155,
-0.010216858237981796,
-0.024337025359272957,
0.0296267569065094,
0.004108605906367302,
-0.01869535818696022,
-0.011304665356874466,
-0.008169220760464668,
-0.011880563572049141,
-0.024571651592850685,
0.0060256002470850945,
-0.029946699738502502,
-0.016701044514775276,
0.0064895180985331535,
-0.008814440108835697,
0.02538217417895794,
0.0273231640458107,
-0.00724138505756855,
0.002091629896312952,
0.011827239766716957,
0.0032927505671977997,
-0.013192331418395042,
-0.010952727869153023,
-0.045176003128290176,
0.013234990648925304,
-0.03758268058300018,
-0.017628880217671394,
0.006297552026808262,
-0.017308935523033142,
-0.03163173422217369,
0.0013397628208622336,
0.022801296785473824,
-0.004076611716300249,
-0.00037593345041386783,
-0.019505880773067474,
-0.0037140091881155968,
-0.0007358697475865483,
0.0031727717723697424,
-0.012221836484968662,
-0.05690725892782211,
0.033060815185308456,
-0.0011317996541038156,
0.03677215799689293,
-0.005209744442254305,
-0.006750805303454399,
-0.058187033981084824,
-0.00007727798947598785,
-0.00029794726287946105,
0.0021996106952428818,
0.013874877244234085,
0.0037620007060468197,
0.005577679257839918,
0.001197121455334127,
0.043896231800317764,
-0.006462856195867062,
0.004668506793677807,
-0.01523996889591217,
-0.018983306363224983,
-0.002346251392737031,
-0.004044617526233196,
0.027792414650321007,
0.024081071838736534,
0.024614309892058372,
-0.02738715335726738,
-0.0005335722235031426,
0.00498578418046236,
-0.001779685029760003,
-0.029776062816381454,
-0.005039107985794544,
0.0006308883312158287,
0.011347324587404728,
-0.028816232457756996,
-0.0060682594776153564,
-0.0043352325446903706,
0.011816575191915035,
-0.00010998053039656952,
-0.011528626084327698,
-0.011155358515679836,
-0.0014410782605409622,
-0.019761836156249046,
-0.02617136761546135,
0.019409898668527603,
-0.006126915570348501,
0.020199092105031013,
-0.0044632102362811565,
0.007417353801429272,
-0.00411393865942955,
0.049228619784116745,
0.00831319484859705,
0.0007092077867127955,
-0.03835054486989975,
-0.027707096189260483,
0.027301834896206856,
-0.023910434916615486,
-0.008467834442853928,
0.013352303765714169,
0.02459298074245453,
-0.032634224742650986,
-0.026043390855193138,
0.05289730429649353,
-0.008099899627268314,
-0.006196236703544855,
-0.03948101028800011,
-0.028453629463911057,
0.002532884944230318,
0.0034020645543932915,
-0.013640251941978931,
0.023547831922769547,
-0.009816928766667843,
-0.009369008243083954,
-0.033359427005052567,
0.023675808683037758,
-0.0024728956632316113,
0.028560278937220573,
-0.02804836817085743,
0.002796838292852044,
-0.00562033848837018,
-0.05784576013684273,
-0.060917217284440994,
0.007012092042714357,
0.012317819520831108,
-0.015250634402036667,
-0.006644157227128744,
-0.026747265830636024,
0.017266277223825455,
0.02099894918501377,
-0.028816232457756996,
0.032079655677080154,
0.03233560919761658,
0.02587275393307209,
0.019132614135742188,
0.01120868232101202,
-0.0024888927582651377,
0.030437279492616653,
-0.005105762742459774,
-0.018674027174711227,
-0.013682911172509193,
0.003300748998299241,
0.031290460377931595,
-0.01493069063872099,
0.02557414025068283,
0.022012103348970413,
-0.0018730018055066466,
0.000584896479267627,
-0.02333453670144081,
-0.023718468844890594,
0.043768253177404404,
-0.017159629613161087,
-0.007284044288098812,
-0.027856402099132538,
0.005583012010902166,
-0.019079290330410004,
0.024507662281394005,
0.041166048496961594,
-0.015495924279093742,
0.00409794133156538,
0.008867763914167881,
0.036857474595308304,
-0.021969445049762726,
-0.010243520140647888,
0.02004978433251381,
0.025851424783468246,
0.0075399987399578094,
-0.00007248717156471685,
-0.014162826351821423,
-0.010216858237981796,
-0.011368654668331146,
0.01031817402690649,
0.0031301125418394804,
0.00011964549048570916,
0.037412043660879135,
-0.0018650032579898834,
-0.0044898721389472485,
0.015335951931774616,
0.017191624268889427,
0.022012103348970413,
-0.011464637704193592,
-0.0025835426058620214,
-0.02787773311138153,
-0.013117678463459015,
-0.013597593642771244,
-0.01681835576891899,
0.0008838435751385987,
-0.021073604002594948,
0.0007065415848046541,
-0.02199077419936657,
0.007113407365977764,
-0.013544268906116486,
0.01790616475045681,
0.0021996106952428818,
-0.025979401543736458,
-0.004820480011403561,
0.02290794439613819,
-0.008697126992046833,
0.028560278937220573,
-0.019665852189064026,
0.0012144517386332154,
-0.04084610193967819,
-0.02192678488790989,
-0.0024169054813683033,
-0.00024512328673154116,
-0.04393889009952545,
0.015485258772969246,
0.003722007852047682,
0.004852474667131901,
0.016242457553744316,
0.029285483062267303,
-0.0037620007060468197,
0.030565256252884865,
-0.040376853197813034,
-0.00047291629016399384,
-0.004481873475015163,
0.006009602919220924,
-0.014824043028056622,
-0.006708146072924137,
-0.014024184085428715,
-0.01055279839783907,
-0.0015143986092880368,
-0.017991481348872185,
-0.04012089967727661,
0.011677932925522327,
-0.018194112926721573,
0.014322797767817974,
-0.006670819129794836,
0.002567545510828495,
-0.020913630723953247,
0.01366158202290535,
-0.05899755656719208,
0.0025915412697941065,
-0.017884833738207817,
0.016071822494268417,
0.01714896410703659,
0.015687890350818634,
-0.03837187588214874,
0.01168859750032425,
0.018908653408288956,
0.005508358124643564,
-0.02399575337767601,
0.001675703446380794,
0.023654479533433914,
-0.02610737830400467,
-0.031098496168851852,
0.04240316152572632,
0.04018488898873329,
-0.03841453418135643,
0.009774269536137581,
-0.009608966298401356,
0.003660685382783413,
0.022588001564145088,
-0.05362251028418541,
0.022438695654273033,
0.00720939040184021,
0.034809838980436325,
0.006766802165657282,
0.027771083638072014,
-0.046327799558639526,
0.03197300806641579,
0.0005485695437528193,
-0.002532884944230318,
0.01202987041324377,
-0.014365456998348236,
-0.02423037774860859,
0.01041948888450861,
0.001841007499024272,
0.011933887377381325,
0.0450906865298748,
0.0064201969653368,
0.011006051674485207,
-0.0007945260149426758,
-0.010499474592506886,
0.0021702824160456657,
0.024678299203515053,
-0.020647011697292328,
-0.010211525484919548,
-0.001951654558070004,
0.015325287356972694,
-0.004212587606161833,
0.04078211635351181,
0.03167439252138138,
-0.010446150787174702,
0.00885709933936596,
-0.0030901196878403425,
0.005662997718900442,
-0.031418439000844955,
0.021190915256738663,
0.09760405868291855,
-0.027835072949528694,
-0.01224316656589508,
0.04218986630439758,
-0.008083902299404144,
0.0037966612726449966,
0.024507662281394005,
0.005545685067772865,
0.02162817120552063,
-0.02574477717280388,
-0.0028768242336809635,
-0.008041243068873882,
0.004351229872554541,
-0.0020649677608162165,
0.0520014613866806,
-0.004444546531885862,
0.02557414025068283,
0.03370070084929466,
0.006169574800878763,
0.02834698185324669,
0.011912558227777481,
0.014098837971687317,
0.019889812916517258,
0.027301834896206856,
-0.016573065891861916,
-0.0035033798776566982,
-0.035961635410785675,
0.006217566318809986,
-0.010227522812783718,
-0.0004345897468738258,
0.020711001008749008,
-0.0011957883834838867,
0.031098496168851852,
0.020188426598906517,
-0.0036020290572196245,
-0.03370070084929466,
-0.01061678770929575,
0.005865628365427256,
0.012445797212421894,
0.0043485634960234165,
-0.0015050669899210334,
0.017095640301704407,
-0.020284410566091537,
-0.0070654163137078285,
0.010702106170356274,
0.022310717031359673,
-0.027045879513025284,
0.009113053791224957,
0.011155358515679836,
-0.027408482506871223,
-0.022630661725997925,
0.004287241026759148,
0.0009984899079427123,
-0.012552444823086262,
-0.01672237366437912,
-0.015186645090579987,
0.026043390855193138,
-0.006254892796278,
-0.009075727313756943,
-0.011198017746210098,
-0.00628688745200634,
0.016861015930771828,
0.038563840091228485,
-0.007806618232280016,
-0.010526136495172977
] | 2024-07-22 | 62 | 39034731 | [
"cancer cells",
"allogeneic cell",
"autologous cell",
"novel CAR constructs",
"different CAR T-cell therapies",
"CAR",
"CAR T-cell therapy",
"cancer treatment",
"CAR T-cells",
"treatment cost",
"significant advancements",
"The CAR T-cell products",
"clinical applications",
"cancers",
"T-cells",
"improved understanding",
"Common side effects",
"mechanisms",
"action",
"administration",
"dosage",
"biology",
"a patients own T-cells",
"FDA",
"FDA-approved products",
"efficacy",
"resistance",
"Kymriah",
"a promising approach",
"a wider range"
] | [
"CAR T-cell",
"T-cell",
"cancer therapy",
"clinical application.",
"gene therapy",
"immunotherapy"
] | 0 | 10.2174/0113892010257212231001082741
10.1155/2016/5474602
10.1186/s13045-020-00910-5
10.3389/fimmu.2019.00456
10.1200/JCO.20.01467
10.15419/bmrat.v9i2.726
10.1038/nature22395
10.1038/s41591-022-02182-7
10.1016/S0140-6736(20)32334-5
10.3390/ijms21113906
10.1182/blood.2022015526
10.1016/j.omtm.2016.12.006
10.1038/mto.2016.15
10.1186/1476-4598-13-219
10.1038/s41467-022-32866-0
10.3390/ijms20061283
10.1634/theoncologist.2019-0233
10.3390/v13081528
10.1001/jamaoncol.2018.0977
10.1001/jamanetworkopen.2020.2072
10.1016/j.jtct.2021.03.005
10.1200/JCO.22.00642
10.1056/NEJMoa1709866
10.1158/1078-0432.CCR-18-2035
10.1186/s40164-022-00268-z
10.1056/NEJMoa1804980
10.1182/blood-2019-129120
10.1002/hon.85_2879
10.1056/NEJMoa2116596
10.1158/2159-8290.CD-19-0813
10.1097/01.COT.0000872268.55217.67
10.1001/jama.2020.15456
10.1080/13696998.2021.1894158
10.1056/NEJMoa1914347
10.2147/OTT.S155778
10.2147/TCRM.S72943
10.1182/bloodadvances.2020003698
10.1007/s00277-015-2478-9
10.51731/cjht.2022.250
10.1007/s11899-021-00635-3
10.1056/NEJMoa1817226
10.3389/fimmu.2021.632937
10.1056/NEJMoa2024850
10.1097/MD.0000000000025784
10.1158/2326-6066.CIR-18-0551
10.1038/s41467-021-21177-5
10.1038/s41591-021-01245-5
10.1172/JCI126397
10.1038/s43018-021-00241-5
10.3389/fimmu.2020.01128
10.3389/fonc.2020.01362
10.1038/s41408-022-00716-3
10.1016/S2352-3026(21)00057-0
10.7573/dic.212567
10.1002/cpt.2561
10.1016/j.hemonc.2021.09.004
10.1002/ajh.26151
10.1002/ajh.26301
10.1016/S0140-6736(20)31366-0
10.1080/13696998.2018.1529674
10.1097/HS9.0000000000000524
10.1182/bloodadvances.2020003848
10.1056/NEJMoa1707447
10.1016/S1470-2045(18)30864-7
10.1016/S1470-2045(21)00591-X
10.1186/s13046-022-02327-z
10.1016/j.imlet.2019.05.003
10.7861/clinmedicine.18-4-324
10.1038/mto.2016.11
10.1146/annurev-pathol-020117-043625
10.1016/j.annonc.2020.10.478 | [
"Ong",
"Kimberly",
"Lee",
"Ling",
"Lee",
"Tan",
"Foo",
"Yow",
"Sellappans",
"Hamzah"
] | [
"School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.",
"School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.",
"School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.",
"School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.",
"School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.",
"School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.",
"School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.\nMedical Advancement for Better Quality of Life Impact Lab, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.",
"Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, Malaysia.",
"School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.",
"School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.\nMedical Advancement for Better Quality of Life Impact Lab, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia."
] | [
"39034731",
"27298832",
"32616000",
"30941126",
"33021872",
"28541315",
"36690811",
"33308471",
"32486160",
"36095849",
"28344995",
"27347557",
"25241075",
"36064867",
"30875739",
"32043764",
"29710129",
"32250433",
"33823168",
"36399695",
"29385370",
"30309857",
"35337365",
"30501490",
"34904798",
"32001516",
"32870282",
"33634729",
"32242358",
"31686856",
"26609233",
"34638136",
"26411584",
"34089485",
"31042825",
"33717171",
"33626253",
"33950974",
"31113804",
"33558511",
"33619368",
"30896447",
"34485921",
"32582204",
"32850436",
"35973981",
"34048683",
"30815024",
"34699774",
"33661537",
"34310745",
"32888407",
"30260711",
"33880433",
"34478487",
"29226797",
"30518502",
"34895487",
"31091431",
"30072559",
"27626062",
"33098993"
] | [] | 8.2471 | 3.595999 |
39034520 | 704 | [Role of Pharmacotherapy in Treatment of Meningiomas]. | Meningiomas constitute the most common primary tumors of the central nervous system. Despite maximum treatment, grade 2/3 meningiomas are associated with a high risk of recurrence. Stereotactic radiosurgery is the treatment of choice as adjuvant treatment for grade 2/3 meningiomas. Currently, pharmacotherapies, including molecular targeted therapy for various growth factors, their receptors, and the associated pathways, have shown limited effectiveness for management of refractory or recurrent meningiomas. Therefore, novel systemic treatment approaches are urgently required in such cases. Recent advances in genetics and epigenetics and the identification of specific genetic alterations have led to new classifications of these tumors and the development of therapeutic targets. Identification of targeted gene mutations may lead to precision-based medicine. Other therapeutic approaches such as immune checkpoint inhibitors rarely elicit a significant response in meningiomas with a high tumor mutation burden. Combination therapies that affect these multiple targets are also considered adjuvant therapeutic options. Comprehensive/in-depth research is warranted to investigate the safety and efficacy of other treatment strategies, including chimeric antigen receptor T-cells, oncolytic virus immunotherapy, and gene therapy. In this article, we review the current evidence regarding the efficacy of systemic treatments available in the literature and discuss recent and ongoing trials for meningiomas. | [
0.012518536299467087,
0.07940517365932465,
0.06020348146557808,
0.03353690728545189,
-0.07015665620565414,
0.007811699062585831,
0.02296716533601284,
0.04241108521819115,
-0.03261205554008484,
-0.01775936596095562,
0.05637194961309433,
-0.02153584733605385,
-0.04060542210936546,
0.014103997498750687,
-0.02066604420542717,
-0.03712621331214905,
0.03798500448465347,
-0.04633069783449173,
-0.00924852304160595,
0.05161556601524353,
0.016746433451771736,
0.0581335723400116,
0.018618157133460045,
-0.02695283852517605,
0.009226502850651741,
0.027789609506726265,
-0.00987059623003006,
0.033735089004039764,
-0.009094380773603916,
-0.012100150808691978,
0.035056307911872864,
0.002087799133732915,
-0.01789148896932602,
0.004527922719717026,
-0.043886445462703705,
-0.0068593211472034454,
0.010674336925148964,
-0.02756940759718418,
-0.005692245904356241,
-0.004098527133464813,
0.03247993066906929,
-0.007492404896765947,
-0.012386415153741837,
0.04866484925150871,
-0.013212176039814949,
0.019410887733101845,
-0.0027291399892419577,
-0.06068792939186096,
-0.004153577610850334,
-0.02902274578809738,
-0.051131121814250946,
0.016372088342905045,
0.03734641522169113,
0.05593154579401016,
-0.02159089781343937,
0.04593433067202568,
-0.020996348932385445,
-0.04553796723484993,
0.03166517987847328,
-0.00693088723346591,
0.030982552096247673,
-0.008279629983007908,
0.024332424625754356,
0.007051998749375343,
-0.05003010481595993,
-0.01707673817873001,
-0.02492697164416313,
-0.020732106640934944,
0.014170059002935886,
-0.0010721130529418588,
-0.007376797962933779,
-0.07099342346191406,
0.013223186135292053,
-0.0016212441259995103,
0.0048692370764911175,
0.02417828142642975,
0.02336353063583374,
-0.006121641490608454,
0.005642700009047985,
0.015348143875598907,
0.007178615313023329,
-0.01942189782857895,
0.031489018350839615,
0.013443388976156712,
-0.056548111140728,
0.010597266256809235,
-0.0010143097024410963,
0.009881606325507164,
-0.08513045310974121,
-0.0531129464507103,
-0.028428198769688606,
0.02309928834438324,
-0.037016112357378006,
0.04014299437403679,
-0.04131006821990013,
-0.034924183040857315,
0.03642156347632408,
-0.0254994984716177,
0.0200825072824955,
-0.0006213851738721132,
-0.0018909926293417811,
-0.0028461229521781206,
-0.010828479193150997,
0.00414256751537323,
0.054213959723711014,
0.01855209656059742,
-0.018915431573987007,
-0.0002561579458415508,
0.03472600132226944,
0.02153584733605385,
0.06755825877189636,
-0.010366053320467472,
0.028736483305692673,
0.02536737732589245,
-0.021943222731351852,
-0.00999170821160078,
-0.03239184990525246,
-0.015997743234038353,
-0.01505087036639452,
0.04813636094331741,
0.0036250906996428967,
0.033735089004039764,
0.002386449370533228,
-0.024993032217025757,
0.039130061864852905,
-0.02836213819682598,
0.04318179562687874,
-0.033338725566864014,
0.0020327481906861067,
0.009292563423514366,
0.020412812009453773,
-0.027261123061180115,
0.027415264397859573,
-0.01919068582355976,
-0.09283755719661713,
-0.02349565178155899,
-0.012111160904169083,
0.044018566608428955,
-0.014346220530569553,
0.03800702467560768,
-0.0006932951509952545,
-0.025301316753029823,
-0.008384226821362972,
-0.0007597001385875046,
-0.022075343877077103,
-0.023011205717921257,
0.019300786778330803,
0.0340874120593071,
0.003297538962215185,
0.03087245114147663,
-0.030674267560243607,
0.03474802151322365,
0.018056640401482582,
0.02019260823726654,
-0.05302486568689346,
-0.01836492493748665,
-0.017715325579047203,
0.05223213508725166,
-0.009353119879961014,
-0.04659494012594223,
-0.01066332682967186,
0.05646003037691116,
0.0028241025283932686,
-0.027261123061180115,
0.04131006821990013,
0.033867210149765015,
-0.019377857446670532,
0.01894846186041832,
-0.04142017289996147,
0.005397724453359842,
0.047960199415683746,
-0.03362498804926872,
-0.061304494738578796,
-0.0343516580760479,
0.014137027785182,
-0.006479471456259489,
-0.022207465022802353,
-0.0023313984274864197,
0.019598061218857765,
0.014037936925888062,
-0.010333022102713585,
0.02638031169772148,
0.004434336442500353,
0.055006690323352814,
0.023869996890425682,
0.037434499710798264,
-0.03236982971429825,
-0.005901438649743795,
-0.02468474768102169,
-0.04972182214260101,
0.01926775649189949,
-0.04646281898021698,
0.0443929098546505,
0.024728789925575256,
-0.0050674197264015675,
-0.03659772872924805,
0.014357230626046658,
0.040054913610219955,
-0.037302374839782715,
-0.00457196356728673,
0.0066611384972929955,
-0.044304829090833664,
-0.0021277107298374176,
-0.02994759939610958,
-0.05196789279580116,
-0.05729680135846138,
0.019598061218857765,
0.05333314836025238,
-0.00008399537910008803,
0.013597531244158745,
0.023869996890425682,
-0.01398288644850254,
0.048268482089042664,
0.005573886912316084,
-0.004332492593675852,
-0.010971611365675926,
-0.04027511551976204,
0.002376815304160118,
0.021557867527008057,
0.014269149862229824,
0.022163424640893936,
-0.014203089289367199,
-0.03490216284990311,
0.0589263029396534,
0.016856534406542778,
0.03137891739606857,
-0.007057503797113895,
-0.008356701582670212,
-0.002378191566094756,
-0.0030167801305651665,
-0.000445222802227363,
-0.01747310347855091,
0.03047608584165573,
0.001974944956600666,
-0.05461032688617706,
-0.017660275101661682,
-0.01366359181702137,
0.0028296075761318207,
0.03871167451143265,
-0.04848868399858475,
0.05963095277547836,
0.011659745126962662,
0.0019570535514503717,
0.011494592763483524,
-0.02904476597905159,
0.013124094344675541,
-0.006518006790429354,
-0.033074479550123215,
-0.006176692433655262,
0.0039030970074236393,
-0.030410025268793106,
0.015216022729873657,
0.003173674689605832,
-0.004266431555151939,
0.0049683284014463425,
-0.018166741356253624,
-0.009237512946128845,
0.00339663028717041,
-0.025675661861896515,
0.020787157118320465,
-0.005681235808879137,
0.009848576039075851,
-0.0013191532343626022,
-0.046947263181209564,
-0.0636826902627945,
0.015227032825350761,
-0.014951778575778008,
-0.023319490253925323,
0.08310458809137344,
-0.027239102870225906,
-0.020236648619174957,
-0.015337133780121803,
0.015788549557328224,
-0.02677667699754238,
-0.012232272885739803,
-0.03010174073278904,
0.0010466520907357335,
0.025653641670942307,
-0.025235256180167198,
0.0332946814596653,
0.009325593709945679,
0.013575511053204536,
0.07887668907642365,
-0.055006690323352814,
0.002658950397744775,
0.019388867542147636,
-0.0065069966949522495,
0.021150492131710052,
-0.042697347700595856,
-0.058001451194286346,
-0.011923988349735737,
0.016085823997855186,
-0.007844729349017143,
-0.04452503100037575,
0.019829273223876953,
0.017715325579047203,
0.012925911694765091,
-0.027767589315772057,
-0.0033113015815615654,
0.06588471680879593,
0.0034324130974709988,
0.013619551435112953,
0.01887139119207859,
-0.008786097168922424,
-0.01862916722893715,
0.027437284588813782,
0.0019033791031688452,
0.0063638645224273205,
-0.0005856021889485419,
0.014048947021365166,
0.013971876353025436,
-0.03512236848473549,
0.025851823389530182,
0.003773727687075734,
-0.009606353007256985,
0.03800702467560768,
0.026182128116488457,
-0.011246864683926105,
-0.003165417117998004,
-0.024354444816708565,
-0.0072611914947628975,
-0.0037131719291210175,
-0.003985673189163208,
0.022923124954104424,
0.023737875744700432,
-0.043512098491191864,
-0.008703520521521568,
0.010933075100183487,
0.08446984738111496,
-0.038359351456165314,
0.04870888963341713,
0.020126547664403915,
0.020842207595705986,
0.02209736406803131,
0.01813371106982231,
0.018331894651055336,
0.015469255857169628,
-0.0018331893952563405,
-0.022053323686122894,
-0.04027511551976204,
-0.007437353953719139,
0.007393313571810722,
-0.008417257107794285,
0.01736300066113472,
0.011648735031485558,
-0.019675131887197495,
-0.028340118005871773,
0.03472600132226944,
0.027129001915454865,
-0.004337997641414404,
-0.0014464580453932285,
0.009220997802913189,
-0.009314583614468575,
0.0019281519344076514,
-0.00001309605340793496,
0.021623928099870682,
0.033052459359169006,
-0.007393313571810722,
0.008609934709966183,
-0.005846387706696987,
-0.034131452441215515,
-0.031863365322351456,
-0.03190740570425987,
0.05778124928474426,
0.02930901013314724,
0.05531497672200203,
-0.024662727490067482,
0.017109768465161324,
0.00098953687120229,
-0.023583734408020973,
-0.019598061218857765,
0.018034620210528374,
0.004759135656058788,
-0.007090534549206495,
-0.04003289341926575,
0.03976865112781525,
-0.006716189440339804,
-0.0006379003752954304,
0.020357761532068253,
0.05425800383090973,
0.05236425623297691,
-0.004170093219727278,
-0.006639118306338787,
-0.020335741341114044,
-0.0364656038582325,
-0.014753595925867558,
0.022746963426470757,
0.0023424087557941675,
-0.07861244678497314,
-0.005725276190787554,
0.012650658376514912,
0.006573057267814875,
0.042300984263420105,
0.006655633449554443,
-0.005048152059316635,
0.04791615903377533,
-0.02571970224380493,
0.047739993780851364,
0.025059092789888382,
-0.013773693703114986,
0.006275783758610487,
-0.021822109818458557,
-0.04371028020977974,
0.0027828144375234842,
0.031995486468076706,
-0.03239184990525246,
0.002569492906332016,
-0.004365522880107164,
0.006842806003987789,
-0.02415626123547554,
-0.048752930015325546,
0.016085823997855186,
0.03236982971429825,
0.0018579622264951468,
0.044304829090833664,
-0.037544600665569305,
-0.010063273832201958,
0.044811297208070755,
0.014940768480300903,
0.00054259377066046,
0.012364394962787628,
-0.00805942714214325,
-0.0017712573753669858,
0.006842806003987789,
-0.008164023980498314,
-0.01564541831612587,
0.013377328403294086,
-0.005634442437440157,
-0.0012758007505908608,
-0.03996683284640312,
-0.019113615155220032,
0.052716583013534546,
-0.03816116973757744,
-0.04221290349960327,
0.013080053962767124,
0.05104304105043411,
-0.009661403484642506,
0.005138985812664032,
-0.04791615903377533,
0.002079541329294443,
-0.02521323598921299,
-0.000889069342520088,
-0.03666378930211067,
-0.04725554957985878,
0.023980099707841873,
0.0015276578487828374,
-0.002497927052900195,
0.056283868849277496,
-0.03776480257511139,
-0.0687033161520958,
-0.007371292915195227,
-0.023319490253925323,
0.02811991423368454,
-0.0188934113830328,
0.0033333217725157738,
-0.027106979861855507,
0.0716099962592125,
-0.06562047451734543,
-0.01187994796782732,
-0.006055580452084541,
0.027657488361001015,
0.015458245761692524,
-0.004357265308499336,
-0.08918219059705734,
-0.04393048584461212,
-0.013223186135292053,
0.03159911930561066,
-0.009545797482132912,
-0.00571426609531045,
-0.009661403484642506,
0.02930901013314724,
-0.007035483606159687,
-0.03824925050139427,
-0.02219645492732525,
0.04300563409924507,
0.026072027161717415,
-0.012386415153741837,
-0.03485812246799469,
0.046022411435842514,
0.0006323952693492174,
-0.0036250906996428967,
0.049413539469242096,
0.01601976342499256,
-0.00919897761195898,
0.02145877480506897,
0.01926775649189949,
-0.030586186796426773,
0.007773163262754679,
0.025829803198575974,
0.045890290290117264,
-0.023011205717921257,
-0.03074032999575138,
0.0039030970074236393,
-0.007993366569280624,
-0.001877230009995401,
0.005323405843228102,
0.008901703171432018,
-0.04478927701711655,
-0.03565085306763649,
0.013421368785202503,
0.019895335659384727,
0.01366359181702137,
0.007415333762764931,
-0.016295017674565315,
0.028406178578734398,
0.03430761769413948,
-0.024596666917204857,
0.048620808869600296,
0.03177528455853462,
0.0278776902705431,
-0.02677667699754238,
-0.03734641522169113,
-0.0057693165726959705,
-0.0012496516574174166,
0.00693088723346591,
0.008885188028216362,
-0.01707673817873001,
0.015788549557328224,
0.007652051746845245,
-0.016317037865519524,
-0.0004758447757922113,
-0.008532863110303879,
0.007850234396755695,
0.02638031169772148,
-0.008092457428574562,
-0.022901104763150215,
-0.016471179202198982,
-0.021612918004393578,
-0.020335741341114044,
-0.05835377797484398,
-0.013002983294427395,
-0.03338276594877243,
0.00788876973092556,
-0.033977311104536057,
-0.03816116973757744,
0.0038507988210767508,
-0.0335589274764061,
-0.02442050538957119,
-0.023077266290783882,
-0.009732969105243683,
0.002691980917006731,
-0.001198041602037847,
-0.01609683409333229,
0.021315643563866615,
-0.019994426518678665,
0.021888170391321182,
0.03457185998558998,
-0.025807783007621765,
0.016394108533859253,
0.00854937918484211,
0.04450301080942154,
-0.011241359636187553,
0.0343516580760479,
0.012254293076694012,
0.0010459639597684145,
-0.008296145126223564,
-0.015039860270917416,
-0.00933109875768423,
0.03419751673936844,
0.02360575459897518,
-0.008543874137103558,
-0.011560654267668724,
-0.010454134084284306,
-0.025103135034441948,
-0.0035480197984725237,
0.0036443585995584726,
-0.0043269875459373,
0.005950984079390764,
-0.035716913640499115,
0.009386150166392326,
-0.011648735031485558,
0.00956781767308712,
-0.006033560261130333,
-0.057737208902835846,
0.027613447979092598,
0.0010555977933108807,
-0.04721150919795036,
-0.019565030932426453,
0.015116930939257145,
-0.022108374163508415,
-0.0017492370679974556,
-0.02996961958706379,
0.014544403180480003,
-0.0005267667002044618,
0.0015194002771750093,
0.0258958637714386,
-0.06584067642688751,
0.026732636615633965,
-0.008725540712475777,
-0.0010239436523988843,
0.005730781238526106,
-0.021260593086481094,
0.04247714579105377,
-0.04049531742930412,
0.007140079978853464,
-0.007778668310493231,
0.01775936596095562,
-0.01431319024413824,
-0.02349565178155899,
0.03948238492012024,
-0.011219339445233345,
-0.010597266256809235,
-0.017506133764982224,
-0.024706769734621048,
-0.006259268149733543,
0.058265697211027145,
-0.01670239306986332,
-0.036619748920202255,
0.032545994967222214,
0.008819127455353737,
-0.00025409352383576334,
0.05223213508725166,
-0.015348143875598907,
-0.018309874460101128,
-0.015931682661175728,
0.012738739140331745,
-0.02172301895916462,
0.00854937918484211,
0.04562604799866676,
0.01162671484053135,
-0.04685918241739273,
0.016030773520469666,
0.011318430304527283,
0.026974858716130257,
-0.00440130615606904,
-0.028450218960642815,
-0.019807253032922745,
-0.024508586153388023,
0.007921800017356873,
-0.0066060880199074745,
-0.012419445440173149,
-0.03007972054183483,
-0.0073988186195492744,
0.018331894651055336,
0.0024194796569645405,
0.0074648791924119,
0.01860714703798294,
0.00178914878051728,
0.00969993881881237,
-0.006033560261130333,
0.011362471617758274,
0.01609683409333229,
-0.04659494012594223,
-0.02098533883690834,
-0.029727395623922348,
-0.0177043154835701,
-0.028846584260463715,
-0.02051190286874771,
-0.021469784900546074,
-0.013498439453542233,
-0.0076025063171982765,
-0.03681793063879013,
0.02415626123547554,
0.024772830307483673,
0.007613516412675381,
-0.024486565962433815,
-0.014885718002915382,
0.003969158045947552,
-0.0054087345488369465,
0.022350598126649857,
-0.02598394639790058,
0.02149180695414543,
-0.0025075608864426613,
-0.022504739463329315,
0.024728789925575256,
0.05562325939536095,
-0.016614310443401337,
-0.01659229025244713,
0.014203089289367199,
-0.013245206326246262,
0.05725276097655296,
-0.018541086465120316,
0.06218530610203743,
0.02613808773458004,
0.015359153971076012,
0.0057693165726959705,
0.010762418620288372,
0.006892351899296045,
-0.02000543661415577,
-0.020049476996064186,
0.013806723989546299,
-0.010999136604368687,
-0.03890985623002052,
-0.01451137289404869,
0.026336271315813065,
0.030432045459747314,
0.008929228410124779,
0.011197319254279137,
0.0071621001698076725,
-0.00417559826746583,
0.02576374262571335,
-0.041111886501312256,
-0.04029713571071625,
0.007035483606159687,
-0.01894846186041832,
-0.01688956469297409,
0.01625097543001175,
-0.00828513503074646,
-0.011857927776873112,
-0.05830973759293556,
0.044172707945108414,
0.018056640401482582,
0.000047825324145378545,
-0.02439848519861698,
0.03510034829378128,
-0.012518536299467087,
0.010944085195660591,
-0.006699674297124147,
0.048752930015325546,
-0.0072997272945940495,
-0.04562604799866676,
-0.029000725597143173,
0.00030432731728069484,
0.021579887717962265,
-0.002689228393137455,
0.0034847112838178873,
-0.012155202217400074,
0.01990634575486183,
0.0005852581234648824,
-0.0002965858147945255,
-0.021734029054641724,
-0.027371224015951157,
0.02415626123547554,
0.002770428080111742,
-0.010178880766034126,
0.06293399631977081,
-0.03217164799571037,
0.05875014141201973,
-0.018783310428261757,
-0.050778795033693314,
0.003355342196300626,
0.002964481944218278,
-0.0391080416738987,
-0.0005085311713628471,
-0.014126017689704895,
0.022724943235516548,
-0.00687033124268055,
-0.01990634575486183,
0.008846652694046497,
-0.001500132493674755,
0.03454983979463577,
-0.04119996726512909,
-0.07341565936803818,
-0.040979765355587006,
0.006617098115384579,
0.03243589028716087,
0.01583258993923664,
-0.029220929369330406,
-0.009424685500562191,
0.0017272167606279254,
0.0017712573753669858,
0.006050075404345989,
-0.02309928834438324,
-0.003982920665293932,
0.02124958299100399,
-0.01358652114868164,
-0.02113948203623295,
-0.005956489127129316,
-0.017660275101661682,
-0.03569489344954491,
-0.06055580452084541,
0.008186044171452522,
-0.007486899849027395,
-0.04119996726512909,
-0.02323140949010849,
-0.025169195607304573,
0.016724413260817528,
0.013377328403294086,
-0.007051998749375343,
0.023407571017742157,
0.017506133764982224,
-0.036906011402606964,
0.01979624293744564,
-0.023297470062971115,
0.0008814998436719179,
0.005973004270344973,
-0.04197067767381668,
-0.020522912964224815,
-0.017924519255757332,
-0.008092457428574562,
-0.00933109875768423,
-0.033713068813085556,
0.007574980612844229,
0.026710616424679756,
-0.026072027161717415,
0.04434886947274208,
0.00022983680537436157,
0.026820717379450798,
-0.005075677763670683,
-0.013630561530590057,
0.007987861521542072,
0.016614310443401337,
0.010938580147922039,
0.01628400757908821,
-0.01326722651720047,
0.008587914519011974,
0.01638309843838215,
-0.037302374839782715,
-0.023055246099829674,
0.0005136921536177397,
-0.011505602858960629,
0.009639383293688297,
0.00295622437261045,
-0.02185514010488987,
0.025015052407979965,
0.060115400701761246,
-0.005249087233096361,
0.007574980612844229,
-0.038997940719127655,
-0.03666378930211067,
0.019487960264086723,
0.0034186504781246185,
-0.011505602858960629,
-0.017693305388092995,
-0.018453005701303482,
0.009606353007256985,
0.00840624701231718,
0.005780327133834362,
0.037280354648828506,
-0.008279629983007908,
0.035188429057598114,
0.0009152184356935322,
0.005502320826053619,
-0.03776480257511139,
0.0012276313500478864,
-0.03157709911465645,
-0.029000725597143173,
-0.04133208841085434,
0.026094047352671623,
-0.01227631326764822,
0.04685918241739273,
-0.02236160822212696,
-0.021689988672733307,
0.026446372270584106,
0.02109544165432453,
0.02037978172302246,
0.03192942589521408,
0.02560960128903389,
0.014037936925888062,
0.020941298454999924,
0.029881536960601807,
-0.038073085248470306,
-0.00687033124268055,
0.013256216421723366,
-0.00003737428778549656,
0.019388867542147636,
-0.041904617100954056,
0.003091098740696907,
-0.0533771887421608,
-0.011274389922618866,
0.004065496381372213,
0.00854937918484211,
-0.03472600132226944,
0.011648735031485558,
0.02320938929915428,
0.018981492146849632,
-0.02077614702284336,
0.002862638095393777,
-0.01160469464957714,
0.006925382185727358,
-0.0009145303047262132,
-0.013322276994585991,
-0.005857397802174091,
0.02508111298084259,
0.004423326347023249,
0.0015083900652825832,
0.012111160904169083,
-0.010085294023156166,
-0.006886846851557493,
-0.04404058679938316,
0.044657155871391296,
0.018728259950876236,
0.01815573126077652,
0.0054665375500917435,
-0.018717249855399132,
-0.0033250642009079456,
0.05403779819607735,
-0.03219366818666458,
-0.01287086121737957,
-0.042168859392404556,
0.003853551344946027,
-0.023671815171837807,
0.01768229529261589,
0.0076630618423223495,
0.01638309843838215,
0.006193207576870918,
-0.009347614832222462,
0.011934998445212841,
-0.021998273208737373,
-0.021348673850297928,
0.011637724936008453,
0.008670490235090256,
-0.01570046879351139,
-0.01038807351142168,
-0.029771436005830765,
0.020203618332743645,
-0.02100735902786255,
0.015337133780121803,
0.015403195284307003,
-0.0057693165726959705,
-0.007321747485548258,
0.0459783710539341,
0.0038315309211611748,
-0.005961994174867868,
0.011968029662966728,
-0.0008746185339987278,
-0.00399117823690176,
0.024266362190246582,
-0.034527819603681564,
0.02045685239136219,
0.004902267828583717,
0.026336271315813065,
0.021678978577256203,
0.01140651199966669,
-0.04503149911761284,
-0.0048114340752363205,
-0.026996878907084465,
0.03628944233059883,
0.0298595167696476,
-0.013300256803631783,
-0.010580751113593578,
-0.009193472564220428,
-0.004627014044672251,
-0.032281748950481415,
0.0018648435361683369,
-0.004478377290070057,
-0.004649034235626459,
-0.0034048878587782383,
0.01839795522391796,
0.03210558742284775,
0.005356436129659414,
-0.023187369108200073,
0.015127941034734249,
-0.007652051746845245,
0.03470398113131523,
0.022658880800008774,
0.015337133780121803,
0.020732106640934944,
-0.016162894666194916,
0.004178350791335106,
0.050470512360334396,
-0.00005152404628461227,
-0.020049476996064186,
-0.046022411435842514,
-0.044547051191329956,
0.04051733762025833,
-0.0335589274764061,
0.022449688985943794,
-0.008857662789523602,
0.02375989593565464,
0.05553517863154411,
0.030123760923743248,
0.05029435083270073,
0.008615439757704735,
0.02574172243475914,
-0.058662060648202896,
0.006809775717556477,
0.012364394962787628,
0.03179730474948883,
-0.03380114957690239,
0.0012530923122540116,
0.0005450022290460765,
-0.010509184561669827,
-0.017374010756611824,
0.00040015002014115453,
0.014599454589188099,
0.024090200662612915,
-0.01338833849877119,
-0.02217443473637104,
0.02481687068939209,
-0.010971611365675926,
0.016614310443401337,
0.049193333834409714,
-0.023980099707841873,
-0.020732106640934944,
0.018596136942505836,
0.004800423979759216,
0.025653641670942307,
-0.005188531707972288,
-0.014467332512140274,
0.02558758109807968,
-0.001378332730382681,
-0.022945145145058632,
-0.03485812246799469,
-0.007993366569280624,
0.02785567007958889,
-0.0051142130978405476,
-0.04373230040073395,
0.0028461229521781206,
0.007486899849027395,
0.03472600132226944,
0.037830863147974014,
-0.05082283541560173,
-0.005348178558051586,
0.012573587708175182,
-0.03644358366727829,
-0.013201165944337845,
-0.006688664201647043,
0.007696092594414949,
0.04769595339894295,
-0.012441465631127357,
-0.017660275101661682,
0.010338527150452137,
-0.000003486367177174543,
-0.05914650857448578,
-0.06940796226263046,
0.010184385813772678,
-0.00399117823690176,
0.04448099061846733,
-0.024530606344342232,
0.012727729044854641,
0.010173375718295574,
0.01619592495262623,
0.023407571017742157,
0.003938879817724228,
-0.03283225744962692,
-0.01470955554395914,
0.003696656785905361,
-0.017109768465161324,
-0.009320088662207127,
-0.0044150687754154205,
0.019576041027903557,
0.0369940921664238,
-0.00718962587416172,
0.019443918019533157,
-0.0010611028410494328,
0.023341510444879532,
0.0030332952737808228,
0.021921202540397644,
0.004079259466379881,
0.016955625265836716,
-0.034373678267002106,
0.008395236916840076,
-0.013476419262588024,
-0.01625097543001175,
0.006094116251915693,
-0.013729652389883995,
0.04897313192486763,
0.023539694026112556,
-0.030454065650701523,
-0.035849038511514664,
-0.0012248788261786103,
-0.021227562800049782,
0.04901717230677605,
-0.03681793063879013,
-0.04214683920145035,
-0.0258958637714386,
-0.02730516344308853,
-0.0005608293577097356,
0.02417828142642975,
-0.02349565178155899,
0.011791867204010487,
-0.0027084960602223873,
-0.022636860609054565,
-0.013619551435112953,
0.029793456196784973,
-0.016217945143580437,
0.015711478888988495,
-0.041640374809503555,
-0.021745039150118828,
0.006875836290419102,
0.01747310347855091,
0.022614840418100357,
-0.0015909661306068301,
-0.03327266126871109,
0.0006375563098117709,
0.007079524453729391,
0.0005787208210676908,
-0.007569475565105677,
-0.024772830307483673,
-0.0039030970074236393,
-0.013025003485381603,
-0.015337133780121803,
0.006028055213391781,
-0.0372583344578743,
0.02032473124563694,
-0.03034396469593048,
0.004194865934550762,
-0.01105969212949276,
0.02362777478992939,
0.005659215152263641,
0.010448629036545753,
-0.012892881408333778,
-0.016636330634355545,
-0.02130463346838951,
0.03525448963046074,
-0.017252899706363678,
-0.02320938929915428,
0.0038232733495533466,
0.005042647011578083,
-0.0294631514698267,
-0.00473711546510458,
-0.02862638048827648,
0.018430985510349274,
-0.0077621531672775745,
0.005818862468004227,
-0.023671815171837807,
0.0258958637714386,
-0.02915486879646778,
0.012166212312877178,
0.0076025063171982765,
0.004131557419896126,
-0.012914901599287987,
-0.016504209488630295,
-0.030255882069468498,
-0.012342373840510845,
0.006644623354077339,
-0.02576374262571335,
0.04958970099687576,
0.008290640078485012,
-0.02508111298084259,
-0.017561184242367744,
0.009243017993867397,
0.006688664201647043,
-0.01654824987053871,
0.024772830307483673,
0.01668037287890911,
0.020357761532068253,
0.0005742479697801173,
0.004453604109585285,
-0.026072027161717415,
-0.02825203537940979,
-0.019355837255716324,
0.01781441643834114,
0.031114673241972923,
-0.042719367891550064,
0.016614310443401337,
0.03666378930211067,
0.015348143875598907,
-0.021678978577256203,
-0.0325019508600235,
0.04584624990820885,
0.0035039791837334633,
0.03644358366727829,
-0.010355043224990368,
0.04119996726512909,
-0.009909131564199924,
-0.004624261520802975,
0.007409828715026379,
0.005653710104525089,
0.030520126223564148,
-0.01537016499787569,
-0.018563106656074524,
0.0014726071385666728,
0.0052656023763120174,
-0.0028062111232429743,
-0.004164587706327438,
0.048092320561409,
-0.001182902604341507,
-0.007839224301278591,
0.02968335524201393,
0.05817761272192001,
-0.0007686458411626518,
-0.01823280192911625,
-0.019168665632605553,
-0.021844130009412766,
0.023715855553746223,
0.0018249318236485124,
0.031643159687519073,
-0.0022405649069696665,
-0.007877759635448456,
0.014148037880659103,
-0.0006884782342240214,
-0.019840283319354057,
0.014015916734933853,
0.012694698758423328,
-0.017186839133501053,
-0.006617098115384579,
0.054081838577985764,
-0.03419751673936844,
-0.005004111677408218,
-0.01314611453562975,
0.04472321644425392,
0.035584792494773865,
0.04168441519141197,
0.012408435344696045,
-0.0008801235817372799,
-0.014015916734933853,
0.005593154579401016,
-0.004844464361667633,
-0.004170093219727278,
-0.025697682052850723,
0.016636330634355545,
-0.03195144608616829,
0.004483882337808609,
0.022636860609054565,
0.015634408220648766,
0.01902553252875805,
0.020809177309274673,
0.0026052759494632483,
0.0020079754758626223,
-0.004082011990249157,
-0.021954232826828957,
0.0004772210377268493,
0.010542214848101139,
0.006611593067646027,
0.001195289078168571,
-0.031334877014160156,
-0.004159082658588886,
0.026094047352671623,
-0.009997213259339333,
0.023869996890425682,
0.007866749539971352,
0.013619551435112953,
0.0023836966138333082,
0.004263679031282663,
-0.027217082679271698,
-0.03628944233059883,
-0.020104527473449707,
-0.028318097814917564,
0.014489352703094482,
-0.01860714703798294,
-0.01755017414689064,
0.006182197481393814,
-0.020544933155179024,
-0.004293957259505987,
-0.010564235970377922,
0.004032466094940901,
-0.03824925050139427,
0.01932280696928501,
0.0066721485927701,
-0.03494620695710182,
-0.00007676996756345034,
-0.0014148037880659103,
0.030277902260422707,
-0.016140874475240707,
0.017616234719753265,
0.03285427764058113,
-0.02053392305970192,
0.023980099707841873,
-0.0005856021889485419,
-0.017219869419932365,
-0.0033470846246927977,
0.014236119575798512,
-0.009006300009787083,
-0.015689458698034286,
0.013806723989546299,
-0.01160469464957714,
0.07006857544183731,
0.0018524571787565947,
-0.012265303172171116,
0.0045141601003706455,
0.01451137289404869,
0.009716453962028027,
0.03362498804926872,
-0.007932811044156551,
0.006897856947034597,
0.004544437862932682,
0.021029379218816757,
-0.011235854588449001,
0.01717582903802395,
-0.03626742213964462,
-0.029132848605513573,
-0.02576374262571335,
0.0004930481081828475,
0.04646281898021698,
0.011125752702355385,
-0.03155507892370224,
-0.006980433128774166,
-0.007591496221721172,
-0.011703785508871078,
0.005455527454614639,
0.00894574448466301,
-0.007123564835637808,
0.012265303172171116,
-0.029771436005830765,
-0.020093517377972603,
-0.0021098193246871233,
-0.00005358844646252692,
0.016471179202198982,
-0.00022398766304831952,
0.00811447761952877,
-0.02706293947994709,
0.015227032825350761,
0.00950175616890192,
0.006919877137988806,
-0.0052133044227957726,
-0.004717847798019648,
0.031995486468076706,
-0.007079524453729391,
0.009589837864041328,
0.029749415814876556,
0.02298918552696705,
0.008235589601099491,
-0.007597001269459724,
0.048885051161050797,
0.03723631426692009,
-0.01598673313856125,
0.03494620695710182,
-0.029220929369330406,
-0.002770428080111742,
-0.011439542286098003,
0.032237708568573,
-0.03021184168756008,
-0.010795448906719685,
-0.024332424625754356,
0.02259282022714615,
-0.0356728732585907,
0.023473631590604782,
-0.014566424302756786,
-0.019631091505289078,
0.00038982799742370844,
0.013773693703114986,
-0.0067051793448626995,
-0.05712063983082771,
0.00024015882809180766,
0.0075584654696285725,
-0.022350598126649857,
0.015557336620986462,
-0.03314054012298584,
-0.01338833849877119,
0.04452503100037575,
0.03155507892370224,
-0.0024181033950299025,
0.034527819603681564,
0.01018989086151123,
-0.008868672885000706,
0.02836213819682598,
0.009259533137083054,
-0.02402414008975029,
-0.011714795604348183,
-0.0220643337816,
-0.0388437956571579,
-0.0033443321008235216,
0.028185974806547165,
0.0018565859645605087,
-0.0005549801862798631,
0.01879432052373886,
0.01807866059243679,
0.04580220952630043,
-0.011252369731664658,
-0.04379836469888687,
-0.012683688662946224,
-0.02706293947994709,
0.006908867042511702,
0.0011134010273963213,
-0.01338833849877119,
-0.011714795604348183,
0.012639648281037807,
-0.012155202217400074,
-0.0012448347406461835,
0.008296145126223564,
0.009413675405085087,
0.011169794015586376,
-0.016999665647745132,
0.007079524453729391,
0.012232272885739803,
0.03935026377439499,
-0.021029379218816757,
0.005736286286264658,
-0.016790473833680153,
-0.02679869718849659,
0.023517673835158348,
-0.005078430287539959,
0.0377868227660656,
-0.0073602828197181225,
0.03203952684998512,
-0.004951813258230686,
-0.016823504120111465,
0.0032342304475605488,
0.017274919897317886,
0.005461032502353191,
-0.005045399535447359,
0.02011553756892681,
0.009947667829692364,
-0.01881634071469307,
0.02185514010488987,
-0.020963318645954132,
0.0067602298222482204,
-0.024090200662612915,
0.004260926507413387,
-0.04751979187130928,
-0.005923458840698004,
0.010008223354816437,
0.0036140806041657925,
-0.016658350825309753,
-0.010261456482112408,
-0.020996348932385445,
-0.02072109654545784,
0.001200105994939804,
-0.005642700009047985,
-0.01688956469297409,
-0.01668037287890911,
-0.03203952684998512,
-0.012100150808691978,
0.011868937872350216,
-0.02439848519861698,
-0.02030271105468273,
-0.016239965334534645,
-0.009110895916819572,
-0.010487164370715618,
-0.0050123692490160465,
0.022240495309233665,
0.01696663536131382,
0.014412282034754753,
-0.0404292568564415,
0.013729652389883995,
0.008175034075975418,
0.0029286989010870457,
-0.022680900990962982,
-0.018408965319395065,
0.021425744518637657,
0.018992502242326736,
-0.006314319092780352,
-0.010569741018116474,
-0.014280159957706928,
0.03626742213964462,
-0.017120778560638428,
-0.019355837255716324,
0.0012358889216557145,
-0.004332492593675852,
0.00897326972335577,
0.02338555082678795,
-0.011307420209050179,
-0.024662727490067482,
0.005474795587360859,
0.011026661843061447,
0.032656095921993256,
0.02211938425898552,
-0.006440935656428337,
-0.04553796723484993,
-0.01299197319895029,
-0.011615704745054245,
-0.0003850110515486449,
0.008340186439454556,
0.03950440511107445,
0.030145781114697456,
-0.017935529351234436,
-0.002475906629115343,
0.0006155360024422407,
-0.05989519879221916,
-0.011274389922618866,
-0.00712906988337636,
-0.016339058056473732,
0.021866150200366974,
-0.021899182349443436,
-0.005053657107055187,
0.0372583344578743,
0.010410093702375889,
-0.011791867204010487,
0.02170099876821041,
-0.07997770607471466,
0.00805942714214325,
-0.03256801515817642,
-0.05003010481595993,
0.0114285321906209,
-0.014808647334575653,
-0.03864561393857002,
0.014004906639456749,
0.008472307585179806,
0.015293093398213387,
0.020522912964224815,
0.00755296042189002,
0.005436259787529707,
-0.004459109157323837,
-0.013729652389883995,
0.0035177418030798435,
-0.006286793854087591,
-0.013245206326246262,
-0.02536737732589245,
0.019939376041293144,
-0.014588444493710995,
0.02077614702284336,
0.029110826551914215,
0.0004376533324830234,
-0.0325019508600235,
-0.0015772035112604499,
0.021954232826828957,
0.023803936317563057,
-0.017429061233997345,
-0.010597266256809235,
0.09134017676115036,
-0.022394638508558273,
-0.024618687108159065,
0.001588213606737554,
-0.009545797482132912,
-0.012496516108512878,
0.02944113127887249,
-0.034659940749406815,
0.009320088662207127,
0.0032149627804756165,
0.00735477777197957,
0.01036054827272892,
0.032149627804756165,
0.06650128215551376,
0.003669131314381957,
-0.013630561530590057,
-0.03203952684998512,
0.008714530616998672,
-0.014302180148661137,
-0.02045685239136219,
0.02536737732589245,
0.007828214205801487,
0.00258050300180912,
0.039394304156303406,
0.012914901599287987,
-0.00580234732478857,
-0.007332757581025362,
-0.013762683607637882,
-0.013421368785202503,
-0.010685347020626068,
-0.0030305427499115467,
-0.001185655128210783,
0.013531469739973545,
0.0038315309211611748,
0.000893886259291321,
-0.00805942714214325,
-0.0055078258737921715,
-0.0507347546517849,
-0.010448629036545753,
0.044679176062345505,
0.013300256803631783,
-0.02143675461411476,
-0.006815280765295029,
0.013157125562429428,
-0.0034516809973865747,
0.01564541831612587,
-0.016735423356294632,
-0.02576374262571335,
-0.005659215152263641,
-0.015028850175440311,
0.03943834453821182,
-0.005293128080666065,
-0.020886247977614403,
0.019410887733101845,
-0.003036047797650099,
0.006314319092780352,
-0.024464545771479607,
-0.026754656806588173,
-0.007437353953719139,
-0.0319734662771225,
-0.033448826521635056,
0.020016446709632874,
0.02640233188867569,
-0.024728789925575256,
0.011890958063304424
] | 2024-07-22 | 1 | 39034520 | [
"adjuvant treatment",
"novel systemic treatment approaches",
"systemic treatments",
"other treatment strategies",
"maximum treatment",
"Other therapeutic approaches",
"meningiomas",
"adjuvant therapeutic options",
"targeted gene mutations",
"therapeutic targets",
"gene therapy",
"molecular targeted therapy",
"specific genetic alterations",
"various growth factors",
"immune checkpoint inhibitors",
"oncolytic virus immunotherapy",
"Recent advances",
"limited effectiveness",
"efficacy",
"such cases",
"new classifications",
"a high tumor mutation burden",
"chimeric antigen receptor T-cells",
"Identification",
"refractory or recurrent meningiomas",
"Stereotactic radiosurgery",
"grade 2/3 meningiomas",
"management",
"epigenetics",
"genetics"
] | [] | 0 | 10.11477/mf.1436204981 | [
"Tamura"
] | [
"Department of Neurosurgery, Keio University School of Medicine."
] | [
"39034520"
] | [] | 10.18926 | 7.398923 |
39033780 | 705 | Discovery of differentially expressed proteins for CAR-T therapy of ovarian cancers with a bioinformatics analysis. | Target antigens are crucial for developing chimeric antigen receptor (CAR)-T cells, but their application to ovarian cancers is limited. This study aimed to identify potential genes as CAR-T-cell antigen candidates for ovarian cancers. A differential gene expression analysis was performed on ovarian cancer samples from four datasets obtained from the GEO datasets. Functional annotation, pathway analysis, protein localization, and gene expression analysis were conducted using various datasets and tools. An oncogenicity analysis and network analysis were also performed. In total, 153 differentially expressed genes were identified in ovarian cancer samples, with 60 differentially expressed genes expressing plasma membrane proteins suitable for CAR-T-cell antigens. Among them, 21 plasma membrane proteins were predicted to be oncogenes in ovarian cancers, with nine proteins playing crucial roles in the network. Key genes identified in the oncogenic pathways of ovarian cancers included | [
0.027939558029174805,
0.011374424211680889,
0.03604158014059067,
0.025299066677689552,
-0.038095295429229736,
-0.026856280863285065,
0.011949916370213032,
-0.04520431160926819,
0.0033344668336212635,
-0.013315298594534397,
0.0140036316588521,
-0.04260895401239395,
-0.003940989729017019,
0.02222977764904499,
0.043963052332401276,
0.006753564812242985,
0.03823070600628853,
0.0024063452146947384,
-0.006149862427264452,
0.022613439708948135,
0.029587045311927795,
0.0010811627143993974,
-0.0318438746035099,
-0.03188901022076607,
-0.0061555043794214725,
-0.013766665011644363,
0.0187542587518692,
0.013540981337428093,
0.0011227730428799987,
0.005873400717973709,
0.011882211081683636,
0.0005747864488512278,
-0.023290488868951797,
-0.02092081680893898,
-0.030218956992030144,
-0.014398577623069286,
0.00031736676464788616,
0.01093998458236456,
0.0029846581164747477,
-0.06526753306388855,
0.01709548942744732,
0.012006336823105812,
0.014996637590229511,
0.04653584212064743,
-0.023155078291893005,
-0.002888742834329605,
0.012875217013061047,
-0.07167693227529526,
-0.002608049428090453,
0.002608049428090453,
-0.026653164997696877,
0.01656513474881649,
-0.021112646907567978,
0.005760559346526861,
-0.04389534890651703,
0.010251651518046856,
-0.055743709206581116,
0.00463214423507452,
0.017400162294507027,
-0.010279862210154533,
-0.01886710152029991,
-0.006228851620107889,
0.03130223602056503,
-0.01993909478187561,
-0.020446881651878357,
-0.012615681625902653,
-0.043534256517887115,
-0.034371525049209595,
0.005139931105077267,
-0.011927347630262375,
0.006601228378713131,
0.0033739611972123384,
0.04258638620376587,
0.013834369368851185,
0.05041758716106415,
-0.00898782629519701,
-0.0032724039629101753,
0.001727885683067143,
-0.05989627540111542,
-0.04421130567789078,
0.06346207112073898,
0.028706880286335945,
0.026946553960442543,
-0.01744529791176319,
0.00541921379044652,
-0.023076089099049568,
0.009726938791573048,
-0.01437600888311863,
-0.04236070439219475,
0.016373302787542343,
-0.055292341858148575,
-0.01051118690520525,
-0.027307646349072456,
0.03450693562626839,
-0.029271088540554047,
0.011870927177369595,
0.0066237966530025005,
-0.06919441372156143,
0.027646170929074287,
0.03516141697764397,
-0.011769370175898075,
0.011870927177369595,
-0.038185566663742065,
0.005690033547580242,
0.011114888824522495,
-0.00389303220435977,
-0.07894392311573029,
-0.02430606260895729,
0.020762838423252106,
0.0005063763237558305,
0.07235398143529892,
-0.018449587747454643,
-0.03225010633468628,
0.03480032458901405,
-0.00391842145472765,
-0.007103373296558857,
-0.017264751717448235,
-0.007859411649405956,
-0.010759438388049603,
0.01083842758089304,
-0.061611466109752655,
0.019634423777461052,
0.005918537266552448,
-0.011481624096632004,
0.014928932301700115,
-0.0016094021266326308,
0.043647099286317825,
0.006279630120843649,
-0.02866174466907978,
-0.062378790229558945,
-0.0060313791036605835,
0.007960968650877476,
0.01895737461745739,
0.013902074657380581,
-0.014014916494488716,
-0.0022215673234313726,
0.024779995903372765,
-0.02200409583747387,
-0.03617699071764946,
0.02155272848904133,
-0.014139041304588318,
-0.026766007766127586,
-0.01389079075306654,
0.01399234775453806,
-0.039494529366493225,
-0.07682250440120697,
-0.0027759012300521135,
0.020886965095996857,
-0.008717007003724575,
0.05836163088679314,
0.009822853840887547,
0.025908412411808968,
0.0881066545844078,
-0.003915600478649139,
0.005151215009391308,
-0.024441471323370934,
-0.027623603120446205,
0.03290458396077156,
-0.04172879084944725,
-0.02036789245903492,
-0.039607372134923935,
0.028052400797605515,
-0.025524750351905823,
0.00018530692614149302,
0.0324757881462574,
0.015256172977387905,
-0.0014669396914541721,
0.0028351431246846914,
-0.04870239645242691,
-0.018009506165981293,
-0.012457703240215778,
-0.03452950343489647,
-0.043534256517887115,
0.023606445640325546,
-0.07054851204156876,
0.004933995194733143,
-0.015617265366017818,
0.031121689826250076,
-0.014849943108856678,
-0.007582949940115213,
-0.011380067095160484,
0.018979942426085472,
0.0518619604408741,
-0.024576881900429726,
0.016147620975971222,
0.01603478007018566,
0.02527649886906147,
0.005695675499737263,
-0.03464234620332718,
-0.0024966185446828604,
0.02845863066613674,
-0.0333559513092041,
0.07546840608119965,
0.04416617006063461,
0.05772971734404564,
-0.04565567523241043,
0.02965475060045719,
0.03942682594060898,
-0.01808849535882473,
-0.03692174330353737,
0.03489059582352638,
0.00771271763369441,
0.008276925422251225,
0.0020410208962857723,
-0.031550485640764236,
-0.050282180309295654,
0.025953548029065132,
0.005269698798656464,
0.0131234684959054,
0.03319797292351723,
0.06116010248661041,
-0.020898249000310898,
-0.019668275490403175,
0.020458167418837547,
-0.0010487207910045981,
-0.018765544518828392,
-0.004649070557206869,
0.05402851849794388,
0.056826986372470856,
0.012965490110218525,
0.0034219189547002316,
0.04021671414375305,
-0.030557481572031975,
0.012107894755899906,
-0.015267456881701946,
-0.00018777533841785043,
-0.001523360493592918,
-0.04969540238380432,
0.017479149624705315,
-0.05353201553225517,
-0.035906169563531876,
0.002679985947906971,
0.03342365473508835,
-0.044820647686719894,
-0.007188004441559315,
-0.037643928080797195,
0.011679097078740597,
-0.009354561567306519,
0.006725354120135307,
-0.0169939324259758,
-0.01175808534026146,
0.025547318160533905,
0.013270162045955658,
0.0029169530607759953,
0.01905893161892891,
0.00045242393389344215,
0.0017067278968170285,
-0.07045824080705643,
0.0024303242098540068,
-0.01622661016881466,
0.013100899755954742,
0.002868995536118746,
0.03739567846059799,
0.010341924615204334,
0.0431731641292572,
-0.011041542515158653,
0.02900026924908161,
-0.04105174168944359,
-0.007949684746563435,
-0.004282335285097361,
0.024870269000530243,
-0.012942921370267868,
-0.07244425266981125,
-0.01078200712800026,
-0.03944939374923706,
0.027916990220546722,
-0.009501255117356777,
0.00964794959872961,
0.0036504229065030813,
0.007210572715848684,
0.03443922847509384,
0.012660818174481392,
0.05145572870969772,
0.01083278562873602,
-0.07194774597883224,
0.040464967489242554,
-0.027736444026231766,
0.01852857694029808,
0.0067874169908463955,
-0.022387756034731865,
-0.029361361637711525,
0.018709123134613037,
0.009388414211571217,
0.0014288556994870305,
-0.012525408528745174,
-0.015842948108911514,
0.07072906196117401,
-0.004742164630442858,
-0.01719704642891884,
-0.03563534840941429,
0.024870269000530243,
-0.008085094392299652,
-0.024689722806215286,
-0.028368357568979263,
-0.03073802776634693,
0.015346446074545383,
-0.0032582986168563366,
-0.04346655309200287,
-0.04793507605791092,
0.04107430949807167,
-0.017343740910291672,
0.01198376901447773,
-0.019995516166090965,
-0.01351841352880001,
-0.010883564129471779,
0.0004139872908126563,
0.017738686874508858,
-0.005766201298683882,
-0.0006354387733153999,
0.02536677196621895,
0.05276469141244888,
0.011210804805159569,
0.047348298132419586,
0.028345787897706032,
0.006437608506530523,
0.009715653955936432,
0.03215983137488365,
-0.02299709990620613,
0.004118715412914753,
-0.052358463406562805,
-0.039833053946495056,
-0.02613409422338009,
-0.009247361682355404,
0.036357536911964417,
-0.031866442412137985,
-0.01570753939449787,
0.03200185298919678,
0.0008709954563528299,
0.03315283730626106,
-0.04653584212064743,
0.009061173535883427,
-0.04502376541495323,
0.04703234136104584,
-0.012886500917375088,
0.021191636100411415,
0.005706959404051304,
-0.0708644688129425,
-0.018359314650297165,
0.018923521041870117,
-0.04425644129514694,
-0.005216098856180906,
0.005532055161893368,
-0.015154615044593811,
0.03967507556080818,
0.0109512684866786,
0.035567644983530045,
-0.005046836566179991,
0.008649301715195179,
-0.03518398478627205,
0.009202225133776665,
0.017806390300393105,
-0.003382424358278513,
-0.007870695553719997,
0.034371525049209595,
0.03847895562648773,
-0.023290488868951797,
-0.013687675818800926,
0.008192294277250767,
0.07018741965293884,
0.00618371507152915,
-0.000937995093408972,
-0.003955095075070858,
-0.004383892752230167,
0.061927422881126404,
0.09207867830991745,
0.035138849169015884,
-0.026833711192011833,
0.029225952923297882,
-0.0322275348007679,
-0.03290458396077156,
-0.042338136583566666,
-0.02070641703903675,
-0.005467171315103769,
-0.036650922149419785,
-0.042744364589452744,
0.022286199033260345,
-0.04008130729198456,
0.020334040746092796,
-0.0019281794084236026,
0.00585647439584136,
0.043963052332401276,
-0.010703017935156822,
0.015639834105968475,
-0.04175135865807533,
0.008863700553774834,
-0.009839779697358608,
-0.00541921379044652,
-0.03173103556036949,
-0.07433998584747314,
0.04583622142672539,
-0.020571008324623108,
0.0010296788532286882,
-0.023944970220327377,
0.0015007921028882265,
-0.021439887583255768,
0.034371525049209595,
-0.01241256669163704,
0.054525021463632584,
0.03358163312077522,
-0.01356355007737875,
-0.01797565259039402,
-0.04118715226650238,
-0.016926227137446404,
0.02235390432178974,
-0.03150535002350807,
-0.03227267414331436,
0.03446180000901222,
0.032430652529001236,
0.048973217606544495,
-0.00771271763369441,
-0.019420024007558823,
0.012006336823105812,
0.029587045311927795,
-0.011492908000946045,
0.008773427456617355,
-0.015560844913125038,
-0.007769138086587191,
0.06603485345840454,
-0.046671248972415924,
0.037553656846284866,
0.04649070277810097,
-0.014511418528854847,
0.024373767897486687,
-0.014748386107385159,
-0.00936584547162056,
-0.02396753802895546,
0.06116010248661041,
-0.004499555565416813,
-0.005619507282972336,
-0.07244425266981125,
-0.017072921618819237,
0.05750403553247452,
-0.004835258703678846,
-0.033491361886262894,
-0.0008406692650169134,
-0.030354367569088936,
0.024373767897486687,
0.03213726356625557,
0.006324766669422388,
0.04653584212064743,
-0.04139026626944542,
0.01927333138883114,
-0.014917648397386074,
-0.053125783801078796,
0.0023245352786034346,
-0.013146036304533482,
-0.007233140990138054,
0.0005740812048316002,
-0.02942906692624092,
-0.01972469687461853,
-0.023290488868951797,
-0.01624917797744274,
-0.0006167493993416429,
0.02798469550907612,
-0.002272346056997776,
-0.0390205942094326,
0.02613409422338009,
-0.021654287353157997,
0.011250299401581287,
0.03188901022076607,
0.024035243317484856,
-0.033920157700777054,
-0.02766873873770237,
-0.026878848671913147,
0.0004023505316581577,
0.010652238503098488,
0.00970437005162239,
-0.06436479836702347,
0.02516365796327591,
-0.010973837226629257,
0.030986279249191284,
-0.0019281794084236026,
-0.017795106396079063,
0.052042506635189056,
0.011904779821634293,
0.007464466150850058,
0.029496772214770317,
0.018269041553139687,
0.0028041116893291473,
0.007887621410191059,
-0.03019638918340206,
0.026021253317594528,
-0.030580051243305206,
-0.018133630976080894,
0.022940680384635925,
0.01971341297030449,
-0.021202920004725456,
0.009484329260885715,
0.0662154033780098,
0.014195462688803673,
-0.011148741468787193,
-0.008039957843720913,
0.02112393081188202,
-0.008694438263773918,
0.020300189033150673,
-0.020875679329037666,
-0.0014514239737764,
-0.01008238922804594,
-0.05068840831518173,
0.020898249000310898,
-0.0020861574448645115,
0.013439424335956573,
-0.011859643273055553,
0.03227267414331436,
0.03204698860645294,
0.04924403503537178,
0.022579586133360863,
0.03746338188648224,
0.009145804680883884,
0.028729449957609177,
-0.043286003172397614,
-0.01578652858734131,
0.003850716631859541,
-0.034597206860780716,
-0.022399039939045906,
-0.008293851278722286,
-0.020209915935993195,
-0.005839548539370298,
-0.025253931060433388,
-0.006025736685842276,
-0.006809985265135765,
-0.004953742492944002,
-0.00048239747411571443,
0.01569625549018383,
-0.006793058943003416,
-0.02320021577179432,
0.0032441935036331415,
-0.06942009925842285,
-0.03563534840941429,
-0.044504694640636444,
0.046580977737903595,
-0.006753564812242985,
0.020401746034622192,
0.007921474054455757,
-0.039404258131980896,
-0.039065733551979065,
0.00005822798266308382,
0.01916048862040043,
-0.030760597437620163,
-0.02900026924908161,
-0.002033968223258853,
-0.0033034353982657194,
0.013258878141641617,
-0.0010085210669785738,
0.0017814853927120566,
0.05511179566383362,
0.0008575955289416015,
-0.029790159314870834,
-0.0033852453343570232,
-0.004025620874017477,
0.0399007610976696,
-0.035229120403528214,
0.03480032458901405,
0.006257061846554279,
-0.004265409428626299,
0.017151910811662674,
-0.00422591483220458,
-0.03367190808057785,
-0.01677953265607357,
-0.004900142550468445,
-0.007030026521533728,
0.009433550760149956,
0.010618386790156364,
-0.01313475240021944,
-0.0053994664922356606,
0.015538276173174381,
0.006668933667242527,
0.027533330023288727,
-0.028413493186235428,
-0.009523823857307434,
-0.008739574812352657,
-0.027488192543387413,
0.028729449957609177,
-0.02006322145462036,
0.007114657666534185,
-0.003263940801844001,
-0.04129999503493309,
0.019769832491874695,
-0.0010480155469849706,
-0.004406461026519537,
-0.02059357613325119,
-0.016598986461758614,
0.0028379641007632017,
0.01580909639596939,
-0.019589286297559738,
-0.030376935377717018,
-0.03060261905193329,
0.002444429323077202,
-0.01198376901447773,
0.0012920353328809142,
0.05199737101793289,
-0.0029028479475528,
0.054525021463632584,
-0.0038704639300704002,
-0.0354999415576458,
-0.017366308718919754,
0.014014916494488716,
0.0014570660423487425,
-0.02168813906610012,
-0.019690843299031258,
0.01907021552324295,
-0.0025544497184455395,
-0.031008848920464516,
-0.05077867954969406,
-0.02210565283894539,
0.0005155446706339717,
-0.005924179684370756,
-0.017456581816077232,
0.03520655259490013,
-0.008694438263773918,
0.005190709605813026,
0.042654093354940414,
-0.026088958606123924,
0.02310994267463684,
0.029880432412028313,
0.02376442216336727,
-0.04983081296086311,
0.011154383420944214,
0.005154035985469818,
-0.038185566663742065,
-0.02365158125758171,
-0.011464698240160942,
-0.04258638620376587,
-0.02004065364599228,
-0.007983537390828133,
-0.029383929446339607,
0.002993121277540922,
0.014263167046010494,
0.025547318160533905,
0.01808849535882473,
0.003952274098992348,
-0.047122616320848465,
-0.006516597233712673,
0.024576881900429726,
-0.0031003206968307495,
-0.00932070892304182,
-0.006313482765108347,
-0.028052400797605515,
-0.001332940417341888,
-0.0042710513807833195,
-0.02550218254327774,
0.02735278382897377,
-0.033491361886262894,
-0.014533987268805504,
0.03315283730626106,
-0.03358163312077522,
-0.007582949940115213,
0.015730107203125954,
0.005526413209736347,
-0.006116010248661041,
-0.0171180572360754,
-0.016587702557444572,
-0.022274915128946304,
-0.024148084223270416,
-0.004420566372573376,
-0.029022837057709694,
0.016068631783127785,
0.0000284748512058286,
0.045723382383584976,
0.061069827526807785,
-0.049740538001060486,
0.013247593306005001,
-0.00366452825255692,
0.008508250117301941,
0.005137110128998756,
0.0011827200651168823,
0.0017518645618110895,
0.012615681625902653,
-0.020661281421780586,
-0.011769370175898075,
0.06779517978429794,
-0.014454998075962067,
0.032724037766456604,
-0.025863274931907654,
-0.007656296715140343,
0.032408084720373154,
-0.003675812389701605,
-0.05317092314362526,
-0.016429724171757698,
0.026427483186125755,
0.02125934138894081,
0.01971341297030449,
-0.026021253317594528,
-0.0026644703466445208,
-0.00036814544000662863,
-0.013371719047427177,
0.018460871651768684,
-0.024057811126112938,
0.020243767648935318,
-0.007673223037272692,
0.017039068043231964,
-0.02538933977484703,
-0.06765977293252945,
0.014421145431697369,
0.014748386107385159,
0.04409846290946007,
-0.0035770758986473083,
0.008254356682300568,
-0.02202666364610195,
0.006375545635819435,
0.05168141424655914,
0.03696687892079353,
-0.009941337630152702,
-0.01960057020187378,
-0.011357498355209827,
-0.016700543463230133,
0.01508691068738699,
-0.013100899755954742,
0.03856923058629036,
0.02156401425600052,
-0.016294315457344055,
-0.021925106644630432,
0.008463113568723202,
-0.006516597233712673,
-0.021327046677470207,
0.00391842145472765,
-0.023076089099049568,
-0.0017377593321725726,
0.004496734123677015,
0.01905893161892891,
-0.019544150680303574,
0.04579108580946922,
-0.008333345875144005,
-0.002939521335065365,
0.04497862607240677,
0.018359314650297165,
-0.05547288805246353,
0.04118715226650238,
-0.06942009925842285,
0.011870927177369595,
0.003117246786132455,
-0.008378482423722744,
-0.001251835492439568,
-0.02897770144045353,
-0.015007921494543552,
-0.0026475440245121717,
0.003672991180792451,
-0.016147620975971222,
0.0023823664523661137,
-0.0003970610850956291,
0.05055299773812294,
-0.054434746503829956,
-0.0056928545236587524,
-0.0076280864886939526,
-0.03588360175490379,
0.033604204654693604,
0.02221849374473095,
0.0107932910323143,
0.005007341969758272,
-0.005605402402579784,
0.023155078291893005,
0.0063191247172653675,
-0.002458534436300397,
-0.013394287787377834,
-0.010979479178786278,
-0.018235187977552414,
-0.01743401400744915,
-0.005233025178313255,
-0.036019012331962585,
-0.01361997053027153,
-0.04432414844632149,
0.020875679329037666,
0.012107894755899906,
0.0195102971047163,
-0.007887621410191059,
0.04631015658378601,
0.03507114201784134,
0.015278740786015987,
0.01241256669163704,
-0.0006721122772432864,
-0.0010592996841296554,
-0.021970242261886597,
0.017050351947546005,
-0.019025079905986786,
-0.030873438343405724,
0.00930942501872778,
-0.008384124375879765,
0.016091199591755867,
-0.027194805443286896,
0.03529682382941246,
-0.010624028742313385,
0.0036109285429120064,
-0.024531744420528412,
0.03369447588920593,
0.01356355007737875,
-0.032317809760570526,
0.007532170973718166,
0.025569887831807137,
-0.0037971169222146273,
-0.010770722292363644,
0.007684506941586733,
0.001816748408600688,
-0.03495829924941063,
0.002156683476641774,
-0.0004164557030890137,
-0.006099083926528692,
0.0001319716830039397,
-0.07023255527019501,
-0.025457045063376427,
-0.025795569643378258,
0.014443714171648026,
-0.025457045063376427,
-0.0024994395207613707,
-0.007509602699428797,
0.00658994447439909,
0.000017840860891737975,
0.01509819459170103,
0.01351841352880001,
-0.04432414844632149,
0.012717238627374172,
0.021214203909039497,
-0.0037012016400694847,
-0.017840243875980377,
0.01155497133731842,
-0.029045404866337776,
0.002695501782000065,
0.02888742834329605,
0.022297482937574387,
-0.00974950660020113,
0.0031257099471986294,
0.06711813062429428,
-0.026021253317594528,
0.0033796033822000027,
-0.012175599113106728,
-0.0295193400233984,
-0.01971341297030449,
-0.015335162170231342,
-0.02287297509610653,
-0.00029973528580740094,
-0.012525408528745174,
0.020221199840307236,
-0.010663523338735104,
-0.043082889169454575,
0.026969121769070625,
-0.014951501041650772,
-0.010686091147363186,
-0.004705491010099649,
0.019205626100301743,
0.024464040994644165,
0.03692174330353737,
0.010150094516575336,
-0.013033194467425346,
-0.017795106396079063,
-0.03507114201784134,
0.015030489303171635,
-0.0295193400233984,
-0.006307840812951326,
0.019882675260305405,
-0.03703458607196808,
-0.02493797428905964,
0.011092321015894413,
-0.006652007345110178,
-0.019544150680303574,
0.008463113568723202,
0.019566718488931656,
0.00854774471372366,
0.003819685196503997,
-0.0045757233165204525,
0.030376935377717018,
0.039404258131980896,
-0.007165436167269945,
-0.00621192529797554,
-0.05019190534949303,
-0.04965026676654816,
0.04333114251494408,
-0.059760864824056625,
0.032633766531944275,
0.0012934458209201694,
0.005754917394369841,
-0.03791474923491478,
0.027510760352015495,
-0.01851729303598404,
0.017614560201764107,
-0.00541639281436801,
-0.020119642838835716,
-0.019984232261776924,
0.019025079905986786,
-0.05511179566383362,
-0.022602155804634094,
-0.02221849374473095,
0.017298603430390358,
-0.0019549792632460594,
0.015177183784544468,
-0.011904779821634293,
-0.005585655104368925,
0.014996637590229511,
-0.0346197783946991,
-0.0020015262998640537,
-0.03615442290902138,
-0.022940680384635925,
0.04391791671514511,
-0.008333345875144005,
-0.002033968223258853,
-0.0014182768063619733,
0.025005679577589035,
0.005427676718682051,
0.005297909025102854,
0.02900026924908161,
-0.03723770007491112,
0.012232020497322083,
-0.006217567250132561,
-0.010911774821579456,
-0.030692892149090767,
0.05353201553225517,
-0.00899346824735403,
-0.007035668473690748,
-0.03288201615214348,
0.0020847469568252563,
0.030038410797715187,
0.00044290293590165675,
0.004321829881519079,
-0.01486122701317072,
0.015662401914596558,
0.03238551318645477,
-0.016948794946074486,
0.024125516414642334,
-0.025795569643378258,
0.04567824676632881,
0.021078795194625854,
0.011475982144474983,
0.007960968650877476,
0.012841364368796349,
0.023380761966109276,
0.002224388299509883,
-0.0063360510393977165,
0.03127966821193695,
0.022263631224632263,
-0.022195925936102867,
-0.01654256507754326,
-0.011882211081683636,
0.004155388567596674,
-0.015831664204597473,
0.048521850258111954,
-0.014601691626012325,
0.01972469687461853,
-0.0020593577064573765,
0.012536692433059216,
-0.0009372898493893445,
0.02266986109316349,
0.016824670135974884,
-0.03105398453772068,
0.02681114338338375,
-0.012378714047372341,
-0.06463561952114105,
0.0066576492972671986,
-0.020085789263248444,
-0.027713876217603683,
-0.017016500234603882,
0.02854890376329422,
0.018709123134613037,
0.06350720673799515,
-0.01437600888311863,
0.00776349613443017,
0.018156198784708977,
-0.010956911370158195,
-0.023493602871894836,
0.004448776599019766,
0.005918537266552448,
0.028797155246138573,
-0.01952158287167549,
-0.021406035870313644,
0.02484770119190216,
-0.011645244434475899,
0.014804806560277939,
0.01960057020187378,
0.041661087423563004,
0.011289793066680431,
-0.003247014479711652,
-0.04412103071808815,
0.05145572870969772,
0.036899175494909286,
-0.03475518524646759,
-0.01753557100892067,
0.014218030497431755,
-0.023606445640325546,
0.00013038484030403197,
0.003063647076487541,
-0.034258682280778885,
-0.015662401914596558,
-0.00042879776447080076,
0.02593098022043705,
0.024464040994644165,
-0.004835258703678846,
-0.02505081705749035,
-0.039178572595119476,
0.0012398461112752557,
0.006194998975843191,
-0.027646170929074287,
0.0040905047208070755,
0.002575607504695654,
0.032182399183511734,
-0.008999111130833626,
-0.005653359927237034,
0.026766007766127586,
0.0028605323750525713,
-0.02681114338338375,
0.0038732849061489105,
0.015944505110383034,
0.007137225940823555,
0.0315956249833107,
0.04511403664946556,
-0.0396525077521801,
0.004017157945781946,
0.01470324955880642,
-0.03146021440625191,
-0.01579781249165535,
0.04039726033806801,
-0.0093150669708848,
0.04371480271220207,
-0.02157529816031456,
0.026495186612010002,
0.03495829924941063,
-0.017016500234603882,
-0.012649533338844776,
0.028571471571922302,
-0.03771163523197174,
-0.00817536748945713,
-0.019465161487460136,
-0.0507335439324379,
0.004823974799364805,
-0.020085789263248444,
0.01853986084461212,
0.016508713364601135,
0.03333338350057602,
-0.0010670576011762023,
0.006894616410136223,
0.01351841352880001,
-0.024148084223270416,
0.018697839230298996,
0.03452950343489647,
0.046265020966529846,
0.017603276297450066,
-0.015955790877342224,
-0.027307646349072456,
0.020413029938936234,
-0.006550449877977371,
0.020762838423252106,
0.021067511290311813,
-0.012175599113106728,
0.012243304401636124,
-0.022173358127474785,
-0.0014133399818092585,
-0.010973837226629257,
0.03651551529765129,
-0.013202456757426262,
0.00882984884083271,
0.01753557100892067,
-0.02125934138894081,
-0.009292498230934143,
0.03376217931509018,
0.005681570153683424,
0.04698720574378967,
-0.01952158287167549,
0.012277157045900822,
-0.0013992347521707416,
0.018269041553139687,
0.0001504847314208746,
0.0026574176736176014,
-0.01952158287167549,
-0.008316420018672943,
-0.023922400549054146,
0.04039726033806801,
-0.014545271173119545,
0.0028069326654076576,
-0.025005679577589035,
0.01752428710460663,
0.019363604485988617,
0.022410323843359947,
0.028142673894762993,
-0.02778158150613308,
0.008745217695832253,
-0.01089484803378582,
-0.03206956014037132,
0.030241526663303375,
-0.013021910563111305,
0.0040199789218604565,
0.019758548587560654,
0.0019126636907458305,
0.003678633365780115,
0.010189589112997055,
-0.005032731685787439,
0.005594118032604456,
0.019002510234713554,
-0.03136993944644928,
0.014443714171648026,
0.014353440143167973,
-0.014443714171648026,
-0.005348687991499901,
0.025095952674746513,
-0.00888062734156847,
-0.03674119710922241,
-0.02134961448609829,
-0.02604382112622261,
0.0034952659625560045,
0.008852416649460793,
0.01569625549018383,
-0.01356355007737875,
0.01552699226886034,
0.03308513015508652,
-0.005455887410789728,
-0.014601691626012325,
0.029451634734869003,
-0.008903195150196552,
-0.03378475084900856,
-0.048657260835170746,
0.022286199033260345,
-0.0337396115064621,
-0.00882984884083271,
0.008615450002253056,
0.013146036304533482,
0.010200873017311096,
-0.01046605035662651,
-0.0045757233165204525,
-0.03768906742334366,
0.007554739248007536,
-0.0011947095626965165,
0.026540324091911316,
-0.01601221039891243,
0.011081037111580372,
0.007690149359405041,
0.012062758207321167,
-0.030354367569088936,
0.020785406231880188,
-0.012299724854528904,
0.009766433387994766,
-0.008903195150196552,
-0.03886261582374573,
0.049198899418115616,
-0.011086679063737392,
-0.006228851620107889,
0.012830080464482307,
-0.000739817158319056,
0.03712485730648041,
0.03617699071764946,
-0.01591065339744091,
-0.018054641783237457,
0.002517776330932975,
-0.032520923763513565,
0.020176062360405922,
-0.006505313329398632,
0.02678857557475567,
0.053983379155397415,
-0.004804227501153946,
-0.014398577623069286,
0.005303550977259874,
-0.004333114251494408,
-0.015481855720281601,
0.0276913084089756,
-0.005873400717973709,
-0.027059394866228104,
0.026720870286226273,
0.04324086755514145,
0.0020184526219964027,
0.0012074041878804564,
0.014545271173119545,
0.009969547390937805,
-0.0023654401302337646,
-0.01443242933601141,
0.00025089606060646474,
0.030038410797715187,
-0.014951501041650772,
0.005811337847262621,
0.012446419335901737,
-0.0262469369918108,
-0.015007921494543552,
-0.021293193101882935,
-0.005216098856180906,
0.0031877728179097176,
0.03464234620332718,
-0.03527425602078438,
0.01679081656038761,
-0.002283630194142461,
0.01677953265607357,
0.03604158014059067,
0.0061780731193721294,
0.016926227137446404,
0.03746338188648224,
0.00582826416939497,
-0.010449124500155449,
-0.012254588305950165,
-0.026066388934850693,
0.013315298594534397,
-0.007515244651585817,
-0.030151251703500748,
-0.014804806560277939,
-0.005481276661157608,
-0.02006322145462036,
-0.0020113999489694834,
-0.028368357568979263,
0.012491555884480476,
0.012277157045900822,
-0.027646170929074287,
-0.021733276546001434,
0.020898249000310898,
0.0027900063432753086,
-0.016046063974499702,
-0.03389758989214897,
-0.030557481572031975,
-0.022850407287478447,
0.009066815488040447,
-0.0009535108110867441,
-0.014996637590229511,
0.002550218254327774,
0.004823974799364805,
0.021970242261886597,
-0.026088958606123924,
-0.002285040682181716,
-0.01443242933601141,
-0.044527262449264526,
-0.05447988212108612,
0.04671638831496239,
-0.03987818956375122,
-0.004265409428626299,
-0.017953084781765938,
-0.023674149066209793,
-0.013168605044484138,
-0.009512539952993393,
0.016610270366072655,
-0.006855121813714504,
-0.007932758890092373,
0.007447539828717709,
0.004451597575098276,
0.012672102078795433,
0.030151251703500748,
0.027826717123389244,
-0.021507592871785164,
0.005072226282209158,
0.009631022810935974,
-0.03130223602056503,
-0.006042663007974625,
0.011746801435947418,
-0.021496308967471123,
-0.0276913084089756,
-0.014285735785961151,
-0.01971341297030449,
-0.005292267072945833,
0.010804574936628342,
0.013304014690220356,
0.00021016731625422835,
-0.007949684746563435,
0.018235187977552414,
0.014917648397386074,
-0.023132510483264923,
-0.0035516866482794285,
-0.0003395824460312724,
0.002593944314867258,
0.03227267414331436,
0.032724037766456604,
0.03380731865763664,
-0.035793326795101166,
0.007769138086587191,
-0.031550485640764236,
-0.02210565283894539,
-0.03303999453783035,
0.016395872458815575,
-0.01908149942755699,
0.011301077902317047,
-0.03344622626900673,
0.024260925129055977,
0.003969200421124697,
0.0015501603484153748,
-0.0017321172636002302,
0.03732797130942345,
0.006606870796531439,
0.0022892721462994814,
-0.010319356806576252,
-0.014612976461648941,
-0.004017157945781946,
0.016373302787542343,
0.027533330023288727,
0.006392471957951784,
-0.00035580340772867203,
-0.011633960530161858,
0.032746605575084686,
-0.002784364391118288,
-0.001815337804146111,
-0.0061780731193721294,
-0.005613865330815315,
0.007278277538716793,
0.014522702433168888,
-0.03466491401195526,
0.015876801684498787,
0.041683655232191086,
0.008192294277250767,
-0.02037917822599411,
0.03188901022076607,
0.01171294879168272,
-0.007532170973718166,
-0.0032611198257654905,
-0.037305403500795364,
-0.021507592871785164,
0.017953084781765938,
-0.007041310425847769,
0.005503844935446978,
-0.04190933704376221,
0.0012038778513669968,
-0.007588591892272234,
0.02191382274031639,
-0.02516365796327591,
-0.009286856278777122,
-0.011199519969522953,
-0.03484546020627022,
-0.011848359368741512,
-0.004649070557206869,
-0.07266993820667267,
-0.0003559797187335789,
-0.009907484985888004,
-0.00025918285246007144,
-0.015154615044593811,
-0.013360435143113136,
-0.014691964723169804,
-0.006268346216529608,
-0.024915406480431557,
-0.03085087053477764,
0.02843606099486351,
0.0022046410012990236,
0.0280072633177042,
-0.008243072777986526,
0.008395408280193806,
-0.0028506587259471416,
-0.023177646100521088,
0.0025868916418403387,
-0.017140626907348633,
-0.02658546157181263,
0.013258878141641617,
-0.006381187587976456,
0.007244425360113382,
0.041006606072187424,
-0.0256150234490633,
0.02156401425600052,
-0.04177393019199371,
-0.009473045356571674,
0.07948556542396545,
0.009794643148779869,
-0.014297019690275192,
-0.0025600919034332037,
0.0004351450770627707,
-0.00017922406550496817,
-0.013225025497376919,
0.03800502046942711,
-0.034258682280778885,
-0.02115778438746929,
0.01916048862040043,
0.032295241951942444,
-0.04825103282928467,
-0.00007198054663604125,
0.042992617934942245,
-0.0036137495189905167,
-0.0005120183923281729,
0.020119642838835716,
-0.010669165290892124,
0.0009309424785897136,
-0.044617533683776855,
-0.01242385059595108,
0.014127757400274277,
-0.01232229359447956,
0.01993909478187561,
0.03254349157214165,
-0.03647037595510483,
0.02255701832473278,
-0.0047393436543643475,
-0.030264094471931458,
-0.011069752275943756,
0.0071428678929805756,
0.0018421377753838897,
0.0015459287678822875,
0.013823085464537144,
-0.007509602699428797,
-0.017953084781765938,
0.010652238503098488,
-0.013529697433114052,
-0.026224367320537567,
0.045587971806526184,
-0.03188901022076607,
-0.009687444195151329,
-0.008288209326565266,
0.02016477845609188,
-0.004869111347943544,
-0.012672102078795433,
-0.01861885003745556,
-0.03683147206902504,
-0.0015614444855600595,
-0.02169942297041416,
-0.03811786323785782,
0.004601112566888332,
0.002063589170575142,
-0.0008928584866225719,
-0.008355913683772087,
-0.008733932860195637,
-0.0025530392304062843,
0.008807280100882053,
-0.012153031304478645,
0.01733245700597763,
-0.009552034549415112,
-0.02604382112622261,
-0.01002032682299614,
-0.016215326264500618,
0.019690843299031258,
0.015933221206068993,
-0.03258863091468811,
-0.042338136583566666,
-0.011814506724476814,
0.0300835482776165,
-0.036222126334905624,
-0.018246473744511604,
-0.02929365634918213,
-0.00778606440871954,
-0.02496054209768772,
0.024373767897486687,
-0.001787127461284399,
-0.00021369362366385758,
0.013473276980221272,
0.03924627974629402,
-0.05989627540111542,
-0.0014225083868950605,
-0.010347566567361355,
0.004852185025811195,
0.0271271001547575,
0.02626950480043888,
-0.008643659763038158,
-0.0006918595172464848,
0.006990531925112009,
0.03150535002350807,
0.003438845044001937,
0.006245777942240238,
0.0009845421882346272,
0.005286625120788813,
-0.00043585035018622875,
0.008891911245882511,
0.019262045621871948,
-0.029880432412028313,
0.015718823298811913,
-0.0073798350058496,
0.007560381665825844,
-0.008485682308673859,
-0.041661087423563004,
0.024125516414642334,
0.009822853840887547,
0.02264729142189026,
-0.016835954040288925,
0.014590407721698284,
-0.020243767648935318,
0.024892838671803474,
-0.01313475240021944,
-0.0171180572360754,
0.014601691626012325,
-0.009128878824412823,
-0.03653808310627937,
0.02920338325202465,
0.016395872458815575,
0.0006326177390292287,
0.010703017935156822,
0.009439192712306976,
0.02615666389465332,
-0.010612744837999344,
-0.00812458898872137,
-0.007853769697248936,
0.00020470155868679285,
-0.021112646907567978,
-0.020616143941879272,
0.01842701993882656,
-0.01896865852177143,
0.007503960747271776,
0.006296556442975998,
0.037531089037656784,
-0.027962127700448036,
-0.004084862768650055,
-0.046152178198099136,
-0.017163194715976715,
-0.009828495793044567,
-0.0038140432443469763,
0.09013780206441879,
-0.020886965095996857,
0.0016827491344884038,
0.02852633409202099,
-0.0063021983951330185,
-0.0536222867667675,
-0.00018742270185612142,
0.005334582645446062,
0.05402851849794388,
-0.010928700678050518,
0.04215759038925171,
0.005845190491527319,
-0.012728522531688213,
0.01962313987314701,
0.0303995031863451,
-0.016204042360186577,
-0.007667581085115671,
0.06386829912662506,
-0.030331799760460854,
0.00004057445767102763,
-0.030106116086244583,
-0.004671638831496239,
-0.007921474054455757,
0.0023964715655893087,
-0.014500134624540806,
0.00270960689522326,
-0.04096147045493126,
-0.03238551318645477,
0.010917416773736477,
0.013439424335956573,
0.023335624486207962,
-0.018506009131669998,
-0.02006322145462036,
-0.020988522097468376,
-0.01767098158597946,
-0.04892808198928833,
-0.019781118258833885,
-0.02809753641486168,
0.006573018152266741,
0.008790354244410992,
0.0019507476827129722,
-0.019453877583146095,
-0.011701664887368679,
-0.0075773075222969055,
0.01323630940169096,
-0.011814506724476814,
-0.02232005074620247,
-0.019307183101773262,
0.003120067762210965,
-0.03777933865785599,
0.0116113917902112,
0.0023090194445103407,
-0.0007183067500591278,
0.002049484057351947,
-0.05037245154380798,
-0.024328630417585373,
0.014635544270277023,
0.012288440950214863,
-0.0021312939934432507,
-0.028074968606233597,
-0.011137457564473152,
0.012717238627374172,
0.017039068043231964,
0.01592193730175495,
-0.006584302522242069
] | 2024-07-22 | 93 | 39033780 | [
"ovarian cancer samples",
"ovarian cancers",
"gene expression analysis",
"pathway analysis",
"plasma membrane proteins",
"potential genes",
"network analysis",
"Key genes",
"protein localization",
"chimeric antigen receptor",
"CAR)-T cells",
"Target antigens",
"various datasets",
"A differential gene expression analysis",
"crucial roles",
"21 plasma membrane proteins",
"CAR-T-cell antigen candidates",
"Functional annotation",
"CAR-T-cell antigens",
"An oncogenicity analysis",
"oncogenes",
"153 differentially expressed genes",
"60 differentially expressed genes",
"the oncogenic pathways",
"tools",
"GEO",
"nine proteins",
"the GEO datasets",
"four datasets",
"the network"
] | [
"CAR-T-cell antigen",
"chimeric antigen receptor (CAR)-T cell",
"differentially expressed gene (DEG)",
"ovarian cancer",
"protein-protein interaction (PPI) network"
] | 0 | 10.18632/aging.206024
10.1016/j.bulcan.2021.02.017
10.1038/s43018-021-00241-5
10.1038/s43018-021-00277-7
10.3322/caac.21456
10.21037/cco-20-34
10.1002/iub.1722
10.3390/ijms24031973
10.1186/s12943-023-01723-z
10.1016/j.cell.2016.06.017
10.1371/journal.pone.0046317
10.1097/PAS.0b013e318212ae22
10.1158/0008-5472
10.1158/1078-0432.CCR-14-3173
10.1186/1755-8794-2-71
10.18632/oncotarget.19929
10.1016/j.omto.2019.12.006
10.3390/ijms22073495
10.1186/s12885-020-07180-x
10.3390/ijms21020381
10.1158/1538-7445.AM2022-574
10.1371/journal.pone.0146885
10.1089/hum.2017.080
10.1097/CJI.0000000000000203
10.3390/ijms20030660
10.1097/CJI.0000000000000286
10.1007/s00018-023-04905-6
10.31219/osf.io/aev4k
10.1002/jcph.1691
10.1073/pnas.1911154117
10.1186/s13287-022-02719-0
10.1093/noajnl/vdad024
10.3389/fonc.2020.01143
10.1080/21541248.2016.1253528
10.3390/ijms22041979
10.3390/ijms22189838
10.3390/cancers14081961
10.1002/1873-3468.14578
10.3390/diagnostics12092050
10.1186/s40164-022-00344-4
10.1007/s40263-018-0582-9
10.1038/s41408-022-00629-1
10.1136/jitc-2021-003486
10.3389/fonc.2022.876758
10.1136/jclinpath-2020-207073
10.1038/s42003-024-05826-1
10.1371/journal.pone.0271584
10.3390/ijms22168996
10.1186/s12967-020-02598-0
10.1136/bmjopen-2018-028634
10.1053/j.gastro.2022.05.054
10.1016/S1470-2045(23)00396-0
10.1007/s12032-023-02136-0
10.4161/cbt.6.11.4832
10.1074/jbc.M603767200
10.1158/1078-0432.CCR-04-0073
10.1186/s43046-022-00125-4
10.3389/fimmu.2020.02109
10.3390/cancers14071849
10.3390/vaccines8020164
10.7150/ijbs.82317
10.1038/gt.2017.69
10.15698/cst2019.06.188
10.1038/s41388-017-0106-y
10.1515/med-2017-0007
10.18632/oncotarget.10028
10.1186/s40164-022-00352-4
10.18632/oncotarget.17871
10.18632/oncotarget.15650
10.3389/fonc.2020.01767
10.3390/ijms22126567
10.1007/s10555-013-9423-y
10.1016/j.ygyno.2007.02.004
10.3389/fimmu.2023.1121973
10.18632/oncotarget.9977
10.1111/cas.13434
10.3390/cancers14081877
10.1016/j.bbrc.2019.12.058
10.3389/fimmu.2020.00122
10.1038/s41571-023-00819-1
10.1186/s12859-015-0611-3
10.1093/nar/gkx247
10.1155/2022/2443615
10.1016/j.pt.2021.01.005
10.1186/1752-0509-8-S4-S11
10.3389/fmolb.2022.888194
10.1109/TCBB.2014.2361348
10.2174/1570163820666230310140613
10.1093/nar/gkz369
10.1002/advs.202101447
10.1038/s41467-019-09234-6
10.1093/nar/gkaa407
10.1093/nar/gkac959
10.1371/journal.pone.0294236 | [
"Anurogo",
"Liu",
"Chang",
"Chang",
"Qiu"
] | [
"International Ph.D. Program in Cell Therapy and Regenerative Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.\nFaculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar 90221, Indonesia.",
"School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.\nPhD Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.",
"International Ph.D. Program in Cell Therapy and Regenerative Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.",
"International Ph.D. Program in Cell Therapy and Regenerative Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.",
"International Ph.D. Program in Cell Therapy and Regenerative Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.\nDepartment of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei 11031, Taiwan.\nDepartment of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan."
] | [
"39033780",
"34920806",
"34485921",
"29809280",
"32648448",
"29394468",
"36768291",
"36717905",
"27397505",
"23029477",
"21451362",
"18593951",
"25944803",
"20040092",
"28969098",
"31970285",
"33800608",
"32689954",
"31936170",
"26761817",
"29334771",
"29239915",
"30717444",
"31261167",
"37578596",
"33205434",
"32554495",
"35093187",
"37152812",
"32766150",
"27875099",
"33671303",
"34575999",
"35454871",
"36658753",
"36140449",
"36348464",
"30387077",
"35210399",
"35577500",
"35600381",
"33619217",
"38278958",
"35921335",
"34445701",
"33176788",
"31601584",
"35671803",
"37708912",
"37578554",
"17986852",
"16714763",
"15240533",
"12855632",
"35665865",
"32983169",
"35406620",
"32260318",
"37497001",
"28753202",
"31225512",
"29379166",
"28401199",
"27323861",
"36369033",
"28574829",
"28416759",
"33102207",
"34207342",
"23609751",
"17368732",
"37026005",
"27322684",
"29095547",
"35454785",
"23407681",
"31875843",
"32132993",
"37783747",
"25994840",
"28407145",
"35388303",
"33558197",
"25521941",
"35693550",
"26357321",
"36896903",
"31066453",
"34365737",
"30944313",
"32442275",
"36321662",
"37943830"
] | [] | 10.293334 | 5.833079 |
39033659 | 706 | Dihydroartemisinin remodels tumor micro-environment and improves cancer immunotherapy through inhibiting cyclin-dependent kinases. | Cancer immunotherapies are ineffective in nonresponding patients due to absence of immune responses. Here, we identified that dihydroartemisinin (DHA) induced immunogenic cell death (ICD) in hepatocellular carcinoma (HCC), proved by release or surface expose of damage-associated molecular patterns and in vivo protective vaccine activity. Mechanistically, DHA can inhibit cyclin-dependent kinases (CDKs), leading to a buildup of intracellular reactive oxygen species (ROS), which induces immunogenic cell death. In both Hepa1-6 and H22 tumor bearing mice, DHA exerted anti-tumor activity through increasing tumor-infiltrating CD8 | [
0.0011835879413411021,
-0.01599884405732155,
0.039451051503419876,
0.0990779846906662,
-0.0013116574846208096,
0.004652724601328373,
-0.008590511977672577,
0.059942182153463364,
-0.02850743941962719,
-0.008303411304950714,
0.006395033560693264,
-0.020378541201353073,
-0.042873747646808624,
-0.034654777497053146,
0.003912454470992088,
-0.011517816223204136,
0.011028055101633072,
-0.0007641952834092081,
0.0036112801171839237,
0.028777651488780975,
0.02614307776093483,
0.0434592068195343,
-0.03701913729310036,
0.01578492484986782,
0.0013630259782075882,
0.011292639188468456,
0.025940418243408203,
-0.041882965713739395,
0.020108327269554138,
-0.015807442367076874,
0.03307853639125824,
-0.006777835078537464,
-0.012069500051438808,
-0.01959042064845562,
-0.01669689267873764,
0.002500874688848853,
0.0017971958732232451,
0.027764353901147842,
-0.04147764667868614,
-0.00042467020102776587,
0.03650123253464699,
-0.025107262656092644,
-0.00796564482152462,
0.04908863827586174,
-0.04001399502158165,
-0.00986839272081852,
-0.021076589822769165,
-0.036636337637901306,
0.03974378481507301,
-0.02431914210319519,
-0.020716305822134018,
0.05899643898010254,
0.010155493393540382,
0.042108144611120224,
-0.05003438517451286,
0.0011054795468226075,
-0.00960380956530571,
0.01935398392379284,
-0.0373343862593174,
-0.023305844515562057,
0.019455313682556152,
0.010853542946279049,
0.011664181016385555,
-0.055843956768512726,
-0.06345494836568832,
0.009862762875854969,
-0.01911754719913006,
-0.047152113169431686,
0.008736876770853996,
-0.01577366515994072,
-0.0011322193313390017,
-0.025872865691781044,
0.02485956810414791,
-0.002341843442991376,
0.027629246935248375,
-0.00940677896142006,
-0.03150229528546333,
-0.03485743701457977,
-0.009046495892107487,
0.014051060192286968,
-0.007380184251815081,
0.012193347327411175,
0.006839758716523647,
-0.03393420949578285,
0.010769101791083813,
-0.0396537110209465,
-0.025895383208990097,
-0.010082310996949673,
-0.05458296462893486,
-0.03447463735938072,
0.029993608593940735,
0.023576056584715843,
0.0019280801061540842,
-0.012046982534229755,
-0.023733681067824364,
-0.03560052067041397,
0.02530992217361927,
-0.0419280044734478,
-0.01062836591154337,
0.003425508737564087,
0.047377292066812515,
-0.02681860886514187,
-0.023981375619769096,
-0.00048659395542927086,
0.016032619401812553,
0.023958858102560043,
-0.07475884258747101,
0.00508619099855423,
0.018419498577713966,
0.0571499839425087,
0.12438791245222092,
-0.013870918191969395,
-0.03512765094637871,
0.032290417701005936,
-0.03643367812037468,
-0.022146182134747505,
-0.052871618419885635,
0.0014566152822226286,
0.008337187580764294,
0.022742900997400284,
-0.06503118574619293,
0.021988557651638985,
0.020524905994534492,
0.0013897657627239823,
0.040284208953380585,
-0.005291665438562632,
0.037221796810626984,
-0.018565863370895386,
-0.009530627168715,
-0.01760886050760746,
0.0068059819750487804,
0.025512581691145897,
0.009727656841278076,
-0.04154520109295845,
0.012699996121227741,
-0.022044852375984192,
0.022213734686374664,
0.02828226238489151,
0.005162188317626715,
0.01101116742938757,
0.025557616725564003,
-0.03323616087436676,
-0.007031159475445747,
0.011022426187992096,
-0.04084715247154236,
-0.07656026631593704,
-0.012508596293628216,
-0.006670875940471888,
0.04260353371500969,
0.025422511622309685,
-0.012767549604177475,
0.0015283905668184161,
0.12024464458227158,
0.02027721144258976,
-0.020716305822134018,
-0.012632443569600582,
-0.0042220731265842915,
0.033123571425676346,
-0.06052764132618904,
-0.04276115819811821,
-0.04746736213564873,
0.01608891412615776,
0.00383082777261734,
0.001033000648021698,
-0.04944892227649689,
0.0358031801879406,
-0.004542951006442308,
0.009817727841436863,
-0.04598119482398033,
0.006293703801929951,
-0.031840063631534576,
-0.03879803791642189,
-0.04305388778448105,
0.00774046778678894,
-0.03102942369878292,
-0.030826764181256294,
0.03841523826122284,
0.00807823333889246,
-0.01996196247637272,
0.0167757049202919,
-0.01874600537121296,
0.07034537196159363,
-0.00745336664840579,
-0.02051364630460739,
-0.012767549604177475,
0.008213340304791927,
-0.014996804296970367,
0.016415420919656754,
-0.01707969419658184,
0.0000972836060100235,
0.03377658501267433,
-0.002652869326993823,
0.012846361845731735,
-0.005418327637016773,
-0.02386878803372383,
-0.011630404740571976,
0.030128715559840202,
0.0449904128909111,
0.008669324219226837,
-0.014186166226863861,
0.0019435611320659518,
-0.06286948919296265,
-0.039901409298181534,
-0.03535282611846924,
-0.0179015900939703,
0.0043909563682973385,
-1.3193978531944595e-7,
0.025399992242455482,
0.034114353358745575,
-0.010684660635888577,
0.021403096616268158,
0.005342330317944288,
0.013623223640024662,
-0.015345829539000988,
0.027629246935248375,
0.0006706059793941677,
0.027223927900195122,
-0.021740863099694252,
0.04643154889345169,
0.021752120926976204,
-0.03188509866595268,
0.0224839486181736,
0.012767549604177475,
0.02485956810414791,
-0.03262818232178688,
-0.05206098034977913,
0.003729498013854027,
-0.019342726096510887,
-0.021065331995487213,
0.014174907468259335,
-0.04055442288517952,
0.018025439232587814,
0.0036337978672236204,
-0.0062317801639437675,
-0.03483492136001587,
-0.07277728617191315,
0.010864801704883575,
-0.006963606458157301,
0.021605756133794785,
-0.02364361099898815,
0.008213340304791927,
-0.03562304005026817,
0.026570914313197136,
-0.018723487854003906,
-0.053772326558828354,
0.03469981253147125,
0.01912880688905716,
-0.0724620372056961,
0.007346407510340214,
-0.03643367812037468,
-0.05742019787430763,
-0.013105315156280994,
0.00956440344452858,
0.0012082166504114866,
-0.029475701972842216,
0.0027176078874617815,
0.00940677896142006,
-0.013251680880784988,
-0.04384201020002365,
-0.02576027624309063,
0.033213645219802856,
0.0533670075237751,
0.0023601390421390533,
-0.03093935362994671,
-0.027088822796940804,
0.023846270516514778,
-0.06151842325925827,
-0.01033000648021698,
-0.031142013147473335,
0.0005632949760183692,
0.02796701341867447,
0.01062836591154337,
0.03256062790751457,
-0.0032228492200374603,
-0.023666128516197205,
0.019185101613402367,
-0.000043979929614579305,
0.03805495426058769,
0.00497360248118639,
0.026390772312879562,
-0.018791040405631065,
-0.025445029139518738,
-0.023801235482096672,
-0.029295559972524643,
-0.0029441923834383488,
0.02059245854616165,
-0.02463439106941223,
-0.019793080165982246,
0.000007652507520106155,
-0.02463439106941223,
0.03485743701457977,
-0.03805495426058769,
-0.0037182392552495003,
-0.007982533425092697,
-0.0015058728167787194,
0.04426984488964081,
-0.0640854462981224,
-0.004483841825276613,
-0.05818580090999603,
0.021358061581850052,
0.0007353444234468043,
-0.03497002646327019,
-0.053997501730918884,
-0.0563843809068203,
0.04832303524017334,
-0.02614307776093483,
0.014129872433841228,
0.020975260064005852,
0.011512186378240585,
0.04931381717324257,
0.04510300233960152,
0.024792013689875603,
-0.005322627257555723,
0.04289626330137253,
0.006181115284562111,
0.00003340275725349784,
0.03330371528863907,
-0.046611689031124115,
0.02461187355220318,
-0.02873261645436287,
-0.012227124534547329,
0.0182843916118145,
-0.041207436472177505,
-0.01723731867969036,
-0.0205699410289526,
-0.04449502378702164,
0.051115233451128006,
0.06462586671113968,
-0.015976324677467346,
-0.015537229366600513,
-0.030826764181256294,
-0.003425508737564087,
0.040216654539108276,
-0.009091530926525593,
-0.0006326073198579252,
-0.04384201020002365,
-0.031817544251680374,
-0.0091478256508708,
-0.03269573673605919,
0.008601770736277103,
-0.029475701972842216,
0.021662050858139992,
-0.003645056625828147,
0.012812585569918156,
-0.0028484922368079424,
0.0021659235935658216,
-0.010465112514793873,
0.03823509439826012,
-0.010802878066897392,
0.023958858102560043,
0.0011026648571714759,
0.04850317910313606,
-0.01966923289000988,
-0.006000973749905825,
-0.01982685551047325,
0.006130450405180454,
0.02072756551206112,
-0.02729148231446743,
0.005195965059101582,
0.01898244209587574,
-0.03330371528863907,
-0.020401058718562126,
0.0010646661976352334,
0.04384201020002365,
0.057375162839889526,
0.02134680189192295,
-0.021830933168530464,
-0.02125673182308674,
0.0002197237336076796,
-0.030286340042948723,
-0.0018619343172758818,
0.02326080948114395,
-0.04586860537528992,
0.00884383637458086,
-0.026796091347932816,
0.03359644487500191,
0.017496271058917046,
0.0046808719635009766,
0.018959924578666687,
0.014501414261758327,
0.04526062682271004,
-0.019612938165664673,
0.003616909496486187,
-0.027111340314149857,
-0.0022419209126383066,
0.005010193679481745,
0.003768904134631157,
-0.023283326998353004,
-0.05480813980102539,
0.0002853417827282101,
0.03528527542948723,
-0.04384201020002365,
-0.0076672849245369434,
0.004137631971389055,
-0.04985424131155014,
0.036005839705467224,
-0.030241303145885468,
0.03679396212100983,
0.048593249171972275,
0.010082310996949673,
-0.04604874551296234,
-0.027989530935883522,
-0.012767549604177475,
-0.009885281324386597,
0.02211240492761135,
0.003980007953941822,
0.03701913729310036,
-0.03614094853401184,
0.04001399502158165,
0.01911754719913006,
-0.02127924934029579,
0.005967197008430958,
0.011979429051280022,
-0.004056005273014307,
-0.011956911534070969,
-0.059942182153463364,
-0.022472688928246498,
-0.012024465017020702,
-0.02979094907641411,
-0.001605795230716467,
-0.03645619750022888,
-0.009772692807018757,
-0.02203359268605709,
-0.02744910679757595,
0.02186471037566662,
0.013003985397517681,
0.03614094853401184,
-0.011585368774831295,
0.019770562648773193,
-0.049358852207660675,
-0.025062227621674538,
0.08619784563779831,
-0.013713293708860874,
0.04620636999607086,
-0.013769588433206081,
-0.004371253307908773,
-0.053862396627664566,
-0.031682439148426056,
-0.0944843739271164,
0.06620211154222488,
-0.004976416938006878,
0.00250650430098176,
-0.009237896651029587,
-0.06066275015473366,
-0.0464765839278698,
0.002927304245531559,
0.042490944266319275,
0.008449776098132133,
0.026615949347615242,
-0.011427745223045349,
0.014152389951050282,
-0.050799984484910965,
0.0010639624670147896,
-0.0037323127035051584,
0.009097160771489143,
-0.044562578201293945,
0.006693393457680941,
-0.03771718963980675,
0.002879454055801034,
-0.00017363276856485754,
0.023418433964252472,
-0.0472421869635582,
0.003039892762899399,
-0.021763380616903305,
-0.007616620045155287,
0.022056110203266144,
0.04111736640334129,
0.01528953481465578,
-0.013814623467624187,
-0.016415420919656754,
-0.023058149963617325,
-0.02111036702990532,
-0.014400084502995014,
-0.0198155976831913,
0.009919057600200176,
-0.016145208850502968,
0.05066487938165665,
0.016584303230047226,
-0.016573045402765274,
0.011365821585059166,
-0.029745914041996002,
-0.05449289456009865,
-0.05633934587240219,
-0.03193013370037079,
0.04465264827013016,
0.05678969994187355,
-0.008629918098449707,
-0.026165595278143883,
0.028462404385209084,
0.029092900454998016,
-0.006316221784800291,
-0.03402428328990936,
0.004177038092166185,
-0.009209749288856983,
-0.003132778452709317,
0.003273514099419117,
0.03361896425485611,
-0.002792197745293379,
0.0093392264097929,
-0.011540333740413189,
0.0011118126567453146,
-0.009553144685924053,
0.07583969831466675,
-0.04122995212674141,
0.037852294743061066,
0.013611963950097561,
0.005826461128890514,
0.042040590196847916,
-0.002555761719122529,
-0.015503453090786934,
-0.019027477130293846,
0.0005449993186630309,
-0.009783951565623283,
-0.009282931685447693,
-0.056294310837984085,
-0.03681647777557373,
-0.05174573138356209,
0.00026704612537287176,
-0.014478896744549274,
0.004013784229755402,
-0.022540241479873657,
0.02087393030524254,
-0.0041911113075912,
0.005927790887653828,
-0.003985637333244085,
0.00020125215814914554,
-0.02317073754966259,
-0.013003985397517681,
-0.007616620045155287,
-0.03064662218093872,
0.012711255811154842,
-0.00872561801224947,
0.018014179542660713,
0.03499254211783409,
-0.015300793573260307,
-0.013060280121862888,
-0.03618598356842995,
0.019635455682873726,
-0.0005200186860747635,
-0.005742019508033991,
0.04656665399670601,
-0.010797249153256416,
0.0025445029605180025,
-0.032898396253585815,
0.03598332405090332,
0.027764353901147842,
-0.015559747815132141,
-0.014276237227022648,
0.002969524823129177,
0.008325928822159767,
0.01161914598196745,
-0.04429236426949501,
-0.0033917322289198637,
0.004945455119013786,
-0.010960502550005913,
0.018396981060504913,
-0.009665733203291893,
-0.013229163363575935,
-0.024071447551250458,
-0.026998750865459442,
0.019871892407536507,
0.03222286328673363,
0.0024417657405138016,
-0.033191125839948654,
0.0028738246764987707,
0.016753187403082848,
0.022292546927928925,
0.011551592499017715,
-0.0083822226151824,
0.02943066507577896,
-0.04010406881570816,
-0.03343882039189339,
0.009502479806542397,
-0.05854608491063118,
0.05174573138356209,
0.03409183397889137,
-0.014321272261440754,
-0.0034874326083809137,
0.018306909129023552,
-0.008860724978148937,
0.008168304339051247,
0.02681860886514187,
-0.030669139698147774,
0.05273650959134102,
-0.012396006844937801,
0.023058149963617325,
-0.0034621001686900854,
0.00929419044405222,
-0.03782977536320686,
-0.015424640849232674,
0.012350971810519695,
-0.03954112529754639,
0.008140156976878643,
-0.013049021363258362,
-0.020840153098106384,
-0.015278276056051254,
0.06129324436187744,
-0.015109392814338207,
-0.021594498306512833,
0.0028147154953330755,
-0.005511213093996048,
0.02225876972079277,
-0.0020702232141047716,
-0.041590236127376556,
-0.011348932981491089,
0.029745914041996002,
0.001688829273916781,
0.013983506709337234,
-0.0037801628932356834,
-0.0034818032290786505,
0.025895383208990097,
0.02447676658630371,
-0.005032711196690798,
-0.03704165667295456,
-0.01706843450665474,
0.02034476399421692,
-0.031907614320516586,
0.0015748332953080535,
-0.003453655866906047,
-0.034497153013944626,
-0.007329519372433424,
0.009085902012884617,
0.0014988359762355685,
-0.004511989187449217,
-0.03404679894447327,
-0.007774244528263807,
-0.0198043379932642,
-0.024296624585986137,
-0.02537747472524643,
-0.0179015900939703,
-0.004770942963659763,
-0.03909077122807503,
-0.0027865683659911156,
0.000612904317677021,
0.0071662659756839275,
-0.021087849512696266,
-0.02911541797220707,
0.023305844515562057,
-0.046926937997341156,
-0.01729361154139042,
-0.016359126195311546,
0.036095913499593735,
-0.00022464948415290564,
-0.014321272261440754,
-0.032290417701005936,
0.027921978384256363,
0.006141709163784981,
-0.04656665399670601,
0.02409396506845951,
-0.02979094907641411,
0.003850530833005905,
-0.009575662203133106,
-0.0141073539853096,
0.013105315156280994,
0.011472780257463455,
-0.013229163363575935,
0.015537229366600513,
0.023440951481461525,
0.02034476399421692,
0.045530837029218674,
0.007076194975525141,
-0.010071052238345146,
-0.020558683201670647,
-0.003031448693946004,
-0.0002332695439690724,
0.0032904024701565504,
0.011529074981808662,
-0.00402222853153944,
-0.020006997510790825,
-0.005894014146178961,
0.03933846578001976,
-0.05467303469777107,
0.02981346659362316,
-0.014636521227657795,
0.033123571425676346,
0.014321272261440754,
-0.013206644915044308,
0.00754906702786684,
-0.06957976520061493,
-0.02050238847732544,
-0.016370385885238647,
0.016561785712838173,
-0.03909077122807503,
-0.05125034227967262,
-0.007036788854748011,
0.023440951481461525,
0.03958616033196449,
-0.008849465288221836,
-0.005297294817864895,
-0.00887761265039444,
-0.020941482856869698,
-0.008748135529458523,
-0.013780847191810608,
-0.015953807160258293,
0.001984374364838004,
0.04841310903429985,
0.034947507083415985,
0.028755133971571922,
-0.026570914313197136,
-0.0112419743090868,
0.012733773328363895,
0.00007608527812408283,
0.03832516819238663,
0.008973313495516777,
0.00434310594573617,
-0.005877126008272171,
0.005055229179561138,
0.0024093964602798223,
0.03346133977174759,
-0.02485956810414791,
-0.018385721370577812,
0.017518790438771248,
-0.012531113810837269,
0.025039710104465485,
-0.003912454470992088,
0.004331847187131643,
-0.007284483872354031,
0.04163527116179466,
-0.022224994376301765,
-0.005471806973218918,
0.035780664533376694,
-0.01452393177896738,
-0.015390864573419094,
0.006580804940313101,
0.030916836112737656,
0.03188509866595268,
-0.04976417124271393,
-0.006580804940313101,
0.0049313814379274845,
0.0021321470849215984,
-0.05359218269586563,
-0.03150229528546333,
0.0023390285205096006,
-0.02805708535015583,
-0.038685452193021774,
-0.03569059446454048,
-0.03310105577111244,
-0.03933846578001976,
0.0047653135843575,
0.0038054953329265118,
0.027471624314785004,
-0.014422602020204067,
0.02066001296043396,
-0.030826764181256294,
-0.032132793217897415,
0.03701913729310036,
-0.0031158900819718838,
-0.007121230475604534,
0.03902321681380272,
-0.028642544522881508,
0.020175881683826447,
0.006299333181232214,
-0.040892187505960464,
0.009130937047302723,
0.025174815207719803,
-0.010605848394334316,
0.012891396880149841,
0.0020969631150364876,
0.024071447551250458,
-0.023891305550932884,
-0.0002929063339252025,
0.029475701972842216,
0.0005594246904365718,
0.0036197241861373186,
0.005505583714693785,
0.006800352595746517,
0.00880443025380373,
0.03789732977747917,
-0.02142561413347721,
0.019950704649090767,
-0.007993792183697224,
0.007003012113273144,
0.0014594299718737602,
0.014782886020839214,
0.04697197303175926,
-0.010504518635571003,
-0.03019626811146736,
-0.03924839198589325,
0.00831467006355524,
-0.008781912736594677,
0.023148220032453537,
-0.002612055977806449,
0.0005432401085272431,
0.052556369453668594,
-0.020547423511743546,
-0.025287404656410217,
-0.005544989835470915,
0.006811611820012331,
-0.01730487123131752,
-0.015537229366600513,
-0.012474819086492062,
0.005139670800417662,
-0.014512673020362854,
0.056834734976291656,
-0.02553509920835495,
0.01230593677610159,
0.036163464188575745,
-0.07309253513813019,
-0.040892187505960464,
0.017518790438771248,
0.00922100804746151,
0.013386786915361881,
-0.013071538880467415,
-0.02211240492761135,
0.0179128497838974,
0.04366186633706093,
-0.04908863827586174,
0.009119678288698196,
-0.005212853197008371,
0.0171585064381361,
-0.03253811225295067,
0.008556735701858997,
0.0013468413380905986,
-0.03222286328673363,
-0.03033137507736683,
0.012328454293310642,
0.039676230400800705,
-0.0051790764555335045,
0.013882176950573921,
0.018779782578349113,
0.03247055783867836,
0.024296624585986137,
-0.01813802681863308,
-0.027539176866412163,
-0.025197332724928856,
-0.020310986787080765,
-0.03474484756588936,
-0.013240422122180462,
-0.0021673310548067093,
-0.03262818232178688,
0.03551045060157776,
-0.023688646033406258,
-0.03292091190814972,
0.018408238887786865,
0.01911754719913006,
0.006226150784641504,
0.0009408186888322234,
-0.001487577217631042,
-0.02386878803372383,
0.023913823068141937,
0.03026382066309452,
-0.030781729146838188,
0.011945652775466442,
-0.022889267653226852,
0.025399992242455482,
0.010414447635412216,
-0.018396981060504913,
-0.03019626811146736,
-0.02880016900599003,
-0.011033684946596622,
0.00907464325428009,
-0.01989440992474556,
0.002863973146304488,
0.04145513102412224,
0.020997777581214905,
-0.0021968854125589132,
-0.026323219761252403,
-0.05129537731409073,
0.028912758454680443,
-0.020378541201353073,
-0.020524905994534492,
-0.022596536204218864,
-0.011652922257781029,
-0.021155402064323425,
0.010127346962690353,
-0.026098042726516724,
0.006676505319774151,
0.001522761071100831,
-0.006811611820012331,
-0.022134922444820404,
0.03535282611846924,
-0.021290509030222893,
-0.0030342633835971355,
-0.010313117876648903,
0.0007965645054355264,
-0.0026739798486232758,
0.027404069900512695,
-0.024724461138248444,
-0.02956577204167843,
0.0014763183426111937,
0.041500166058540344,
-0.016133949160575867,
0.02438669465482235,
0.01920761913061142,
0.01032437663525343,
-0.014996804296970367,
-0.03985637053847313,
-0.010470741428434849,
-0.025264887139201164,
-0.016955846920609474,
0.008477923460304737,
0.02332836203277111,
-0.029160453006625175,
-0.03823509439826012,
0.011478410102427006,
0.046161334961652756,
-0.00926041416823864,
0.025197332724928856,
-0.011281379498541355,
0.017665155231952667,
-0.0038617898244410753,
0.02241639420390129,
-0.018926147371530533,
-0.0009675584733486176,
-0.0009534849086776376,
0.0179241094738245,
-0.014760368503630161,
0.02416151762008667,
-0.0001986133720492944,
0.03636612370610237,
-0.02219121716916561,
0.029160453006625175,
0.0190499946475029,
-0.010853542946279049,
-0.008455405943095684,
-0.008280892856419086,
-0.035397861152887344,
0.04863828420639038,
0.003155296202749014,
-0.02927304245531559,
0.012148312292993069,
0.0007473069708794355,
0.013792105950415134,
0.02431914210319519,
0.023440951481461525,
0.00041868892731145024,
0.031840063631534576,
-0.030894318595528603,
0.0009175972663797438,
0.007036788854748011,
-0.026030490174889565,
0.01950034871697426,
0.011044943705201149,
0.03742445632815361,
0.05341204255819321,
0.015987584367394447,
-0.005933420266956091,
0.011450262740254402,
-0.00816267542541027,
-0.00877065397799015,
-0.027156375348567963,
-0.01108997967094183,
0.0013489524135366082,
-0.04102729260921478,
0.011258861981332302,
-0.0005298702162690461,
-0.0046414658427238464,
-0.03560052067041397,
0.008449776098132133,
0.04620636999607086,
0.02158323861658573,
0.050890058279037476,
0.03476736694574356,
0.046386513859033585,
0.006344368681311607,
-0.030353892594575882,
0.03409183397889137,
-0.004033487290143967,
0.010391930118203163,
-0.056294310837984085,
-0.013972247950732708,
0.021605756133794785,
-0.017394941300153732,
0.010521406307816505,
0.01707969419658184,
0.009311079047620296,
0.004340291488915682,
-0.0013398046139627695,
-0.04472019895911217,
-0.00449510058388114,
-0.004244591109454632,
-0.037244316190481186,
-0.00243895105086267,
-0.023001855239272118,
0.022990597411990166,
-0.016651857644319534,
0.010183640755712986,
-0.029858501628041267,
0.025580134242773056,
0.02911541797220707,
-0.003132778452709317,
0.020851412788033485,
-0.012103277258574963,
0.03882055729627609,
-0.01990566775202751,
0.023531021550297737,
-0.01101116742938757,
0.005910902749747038,
0.02402641251683235,
0.023508504033088684,
-0.002141998615115881,
0.002355916891247034,
-0.014861698262393475,
-0.007903721183538437,
0.031524814665317535,
-0.053862396627664566,
-0.020772600546479225,
0.015199463814496994,
0.029926056042313576,
0.044404953718185425,
-0.004196740686893463,
0.005575951654464006,
0.019376501441001892,
-0.0014073577476665378,
-0.04656665399670601,
-0.04260353371500969,
0.043414171785116196,
-0.010206158272922039,
0.017552565783262253,
-0.0005689243553206325,
0.02684112824499607,
0.013285457156598568,
-0.007442107889801264,
-0.00846103485673666,
0.03927091136574745,
-0.02530992217361927,
-0.03476736694574356,
0.014704073779284954,
-0.04062197357416153,
0.017057176679372787,
0.014512673020362854,
-0.04305388778448105,
-0.010116087272763252,
0.0077798739075660706,
0.03386665880680084,
-0.016359126195311546,
0.01957916095852852,
-0.007352036889642477,
0.009097160771489143,
0.03823509439826012,
0.006648357957601547,
0.011866840533912182,
0.011208197101950645,
-0.020603718236088753,
-0.03972126543521881,
0.012666219845414162,
-0.04053190350532532,
0.04719715192914009,
0.013814623467624187,
-0.05224112048745155,
-0.029858501628041267,
-0.00952499732375145,
0.0012792882043868303,
0.02524236962199211,
-0.016201503574848175,
-0.024814533069729805,
-0.0042417761869728565,
0.0065751755610108376,
0.008584882132709026,
0.0033382526598870754,
0.0403742790222168,
-0.0034677295479923487,
-0.00111533107701689,
0.050349630415439606,
0.03361896425485611,
0.02158323861658573,
0.006535769440233707,
0.02463439106941223,
-0.005286035593599081,
-0.012125794775784016,
-0.00028551771538332105,
0.01745123602449894,
-0.033956728875637054,
-0.023283326998353004,
-0.04093722254037857,
-0.022810455411672592,
-0.004255849868059158,
0.02087393030524254,
0.0031524815130978823,
-0.0017380868084728718,
0.00998098123818636,
0.021673310548067093,
-0.009423667564988136,
0.004115113988518715,
0.016336608678102493,
-0.0033635850995779037,
-0.03515016660094261,
0.02224751189351082,
0.02461187355220318,
-0.021481908857822418,
0.011652922257781029,
0.005646319594234228,
-0.01036378275603056,
-0.025647688657045364,
-0.028552474454045296,
0.03589325398206711,
-0.005705428309738636,
-0.023823752999305725,
0.01693332940340042,
-0.0028076786547899246,
-0.018655935302376747,
-0.0327632874250412,
-0.020232174545526505,
0.004464138764888048,
-0.025399992242455482,
0.010650883428752422,
-0.021481908857822418,
0.005626616533845663,
0.03188509866595268,
0.007374554872512817,
-0.00940677896142006,
0.004745610523968935,
-0.024431731551885605,
-0.002844270085915923,
-0.029002828523516655,
0.041522685438394547,
0.006406292784959078,
-0.0396086759865284,
-0.006428810302168131,
0.023891305550932884,
0.015818702057003975,
0.006637099198997021,
-0.012846361845731735,
0.013792105950415134,
0.013341751880943775,
-0.03156984969973564,
-0.02195478044450283,
-0.014917992055416107,
0.0221011471003294,
-0.010391930118203163,
-0.01479414477944374,
-0.018791040405631065,
-0.026390772312879562,
0.03161488473415375,
0.00468650134280324,
0.015559747815132141,
-0.0097220279276371,
0.0012919544242322445,
-0.025895383208990097,
-0.007025530096143484,
0.016482973471283913,
0.026570914313197136,
0.03413686901330948,
-0.03787481412291527,
-0.014895474538207054,
-0.005615357309579849,
-0.023080667480826378,
-0.016257796436548233,
0.018340686336159706,
0.016967104747891426,
0.02187597006559372,
-0.000702975201420486,
-0.022540241479873657,
-0.02530992217361927,
-0.015120651572942734,
-0.012936432845890522,
-0.03873048722743988,
0.035870734602212906,
-0.037919849157333374,
-0.01089857891201973,
0.019399018958210945,
-0.00024400065012741834,
0.0024333216715604067,
-0.0009703731629997492,
0.06458083540201187,
-0.007385813631117344,
-0.003031448693946004,
0.0032284788321703672,
-0.01914006657898426,
0.015739889815449715,
0.007785503286868334,
-0.024792013689875603,
0.026278184726834297,
0.0015860921703279018,
-0.02454431913793087,
-0.0070930831134319305,
0.0021687382832169533,
-0.011923135258257389,
0.005837719887495041,
-0.018239356577396393,
-0.02194352261722088,
-0.03033137507736683,
0.0025571691803634167,
0.027111340314149857,
0.025805311277508736,
0.005162188317626715,
0.043706901371479034,
0.03782977536320686,
-0.00760536128655076,
-0.018430758267641068,
-0.026323219761252403,
0.0076109906658530235,
-0.002969524823129177,
-0.019567903131246567,
-0.005871496628969908,
0.027989530935883522,
0.007014271337538958,
-0.017282353714108467,
-0.029092900454998016,
-0.009851504117250443,
-0.020310986787080765,
0.011675439774990082,
0.009575662203133106,
-0.02524236962199211,
0.008449776098132133,
0.02293430268764496,
0.02585034817457199,
-0.007791132666170597,
-0.02005203440785408,
0.014929250814020634,
-0.011878099292516708,
0.004925752058625221,
0.011191309429705143,
-0.005215668119490147,
0.031817544251680374,
0.005663207732141018,
0.00785868614912033,
0.006642728578299284,
0.005955938249826431,
-0.011821805499494076,
0.006924200337380171,
-0.018723487854003906,
-0.002927304245531559,
0.01646045595407486,
-0.02196604013442993,
0.0034423971083015203,
-0.020097069442272186,
-0.03215530887246132,
-0.004998934920877218,
0.028012048453092575,
-0.01928643137216568,
-0.045080482959747314,
0.005488695111125708,
-0.016877034679055214,
0.01608891412615776,
-0.025062227621674538,
0.0179015900939703,
0.016967104747891426,
-0.0089564248919487,
0.017271094024181366,
-0.022900525480508804,
-0.022056110203266144,
0.016190243884921074,
0.016100173816084862,
-0.024184035137295723,
0.0033523261081427336,
0.005643504671752453,
0.041342541575431824,
0.020097069442272186,
0.00964321568608284,
0.0008423036197200418,
0.001853490131907165,
-0.02659343183040619,
0.0003708387666847557,
0.005564692430198193,
0.035330310463905334,
0.023215774446725845,
0.0002466394507791847,
0.032515592873096466,
0.00906901340931654,
-0.017518790438771248,
-0.015064357779920101,
-0.02393634058535099,
-0.014197424985468388,
0.014692815020680428,
-0.02621063031256199,
-0.017203541472554207,
-0.03222286328673363,
-0.014985545538365841,
-0.006046008784323931,
0.01837446354329586,
0.0033466967288404703,
0.014343790709972382,
0.019714267924427986,
0.021369321271777153,
-0.03368651494383812,
0.009316708892583847,
-0.009519368410110474,
0.02501719258725643,
-0.011742993257939816,
0.009277302771806717,
0.02416151762008667,
0.012373489327728748,
0.030398927628993988,
0.00756595516577363,
-0.00861302949488163,
0.044022150337696075,
-0.00207866751588881,
0.020142104476690292,
-0.00892264861613512,
-0.008128898218274117,
-0.0102849705144763,
0.0027513843961060047,
0.020524905994534492,
-0.008624288253486156,
0.05395246669650078,
0.00850607082247734,
-0.00022693643404636532,
0.004962343722581863,
-0.0037660894449800253,
-0.002265846123918891,
0.00998661108314991,
0.01890362985432148,
-0.01762012019753456,
0.018160544335842133,
0.005483065731823444,
0.021526943892240524,
-0.005750463809818029,
-0.008415999822318554,
0.0006122006452642381,
0.016426680609583855,
-0.003031448693946004,
-0.01737242378294468,
-0.018306909129023552,
-0.031840063631534576,
-0.000868339731823653,
0.01120256818830967,
-0.02332836203277111,
-0.0016142394160851836,
-0.011253233067691326,
0.026503361761569977,
0.006428810302168131,
0.01798040233552456,
-0.026953715831041336,
0.05224112048745155,
0.011517816223204136,
-0.006119191646575928,
0.016122691333293915,
0.009215379133820534,
0.026638468727469444,
-0.0021096293348819017,
-0.012148312292993069,
-0.034407082945108414,
0.006265556905418634,
0.02904786355793476,
-0.01655052788555622,
0.04791771620512009,
0.04109484702348709,
-0.018385721370577812,
0.03118704818189144,
0.010960502550005913,
-0.006158597767353058,
0.030466480180621147,
-0.00022201068350113928,
-0.012125794775784016,
-0.01017801184207201,
-0.03368651494383812,
-0.017969144508242607,
0.03589325398206711,
0.023733681067824364,
0.012711255811154842,
0.012778808362782001,
0.03093935362994671,
0.00872561801224947,
-0.024499284103512764,
0.0018647490069270134,
0.020232174545526505,
0.014118612743914127,
-0.004450065083801746,
-0.012880138121545315,
-0.007104341872036457,
-0.009040866047143936,
-0.02623314969241619,
0.04697197303175926,
-0.007228189613670111,
-0.00850607082247734,
0.006243038922548294,
0.01853208802640438,
0.016494233161211014,
0.005043970420956612,
-0.005989714525640011,
0.010814136825501919,
0.04406718537211418,
0.03010619804263115,
-0.013702034950256348,
-0.013488116674125195,
-0.005505583714693785,
-0.03404679894447327,
-0.027223927900195122,
0.004542951006442308,
0.007295742630958557,
-0.031682439148426056,
-0.017653895542025566,
0.03447463735938072,
0.024837050586938858,
-0.005688540171831846,
0.00459080096334219,
-0.008095121942460537,
0.004019413609057665,
-0.016640597954392433,
-0.017169764265418053,
-0.024364177137613297,
-0.031209565699100494,
-0.025557616725564003,
0.0013545819092541933,
-0.0097220279276371,
-0.017631378024816513,
-0.0472421869635582,
-0.037537045776844025,
0.0025515395682305098,
-0.014704073779284954,
-0.00203926139511168,
-0.012868879362940788,
0.003597206436097622,
-0.01540212333202362,
-0.003141222521662712,
0.012429784052073956,
0.004720278084278107,
0.017710190266370773,
-0.0003520153695717454,
-0.0312771201133728,
0.007582843769341707,
0.013510634191334248,
0.02591790072619915,
-0.006417551543563604,
-0.0005847571301274002,
0.015424640849232674,
-0.055528707802295685,
0.0335514098405838,
-0.00850044097751379,
0.028169672936201096,
0.03010619804263115,
-0.016595562919974327,
-0.02758421190083027,
0.009930316358804703,
0.023035632446408272,
0.006462587043642998,
0.029318077489733696,
0.04719715192914009,
0.008697470650076866,
-0.01928643137216568,
0.02203359268605709,
0.00941803865134716,
0.0026542767882347107,
-0.002879454055801034,
0.015751147642731667,
-0.019263913854956627,
-0.00011619497672654688,
-0.0027021269779652357,
0.007768614683300257,
-0.034879956394433975,
-0.0017606045585125685,
-0.028079602867364883,
0.00396593427285552,
-0.012407266534864902,
-0.04262605309486389,
-0.019308948889374733,
0.008855095133185387,
-0.0002770735591184348,
-0.006417551543563604,
0.018194321542978287,
-0.019185101613402367,
0.04323403164744377,
0.010566442273557186,
0.019455313682556152,
0.016437938436865807,
-0.02675105631351471,
-0.017721449956297874,
0.033348750323057175,
-0.018993699923157692,
0.018881112337112427,
0.012778808362782001,
0.03719928115606308,
-0.0011878099758177996,
0.040757082402706146,
0.013139092363417149,
0.010583330877125263,
0.014625261537730694,
0.009913427755236626,
0.025264887139201164,
0.009119678288698196,
-0.011073091067373753,
-0.0028414553962647915,
0.0074927727691829205,
0.02188722789287567,
0.0033382526598870754,
-0.019308948889374733,
0.0037351276259869337,
-0.002301029860973358,
0.003977193031460047,
0.026480844244360924,
0.08777409046888351,
-0.03422694280743599,
-0.025737758725881577,
0.034947507083415985,
-0.022506466135382652,
0.004694945644587278,
0.022900525480508804,
-0.006181115284562111,
0.008511699736118317,
0.011776769533753395,
0.04426984488964081,
-0.0282147079706192,
0.018802300095558167,
0.05291665345430374,
-0.005457733292132616,
-0.012474819086492062,
0.0013095464091748,
0.03240300714969635,
0.007768614683300257,
-0.007689802907407284,
0.023891305550932884,
-0.00043029963853769004,
-0.0029864131938666105,
-0.00394341628998518,
-0.043571796268224716,
0.012925174087285995,
0.002293993253260851,
-0.01844201609492302,
0.006867906078696251,
0.04091470688581467,
-0.0021180734038352966,
-0.015818702057003975,
-0.00400534039363265,
-0.017271094024181366,
-0.00495108449831605,
-0.004835681524127722,
0.008089492097496986,
-0.025490064173936844,
-0.010076682083308697,
0.027989530935883522,
0.00903523713350296,
0.02219121716916561,
-0.04710707813501358,
-0.016584303230047226,
0.004945455119013786,
0.018396981060504913,
-0.008669324219226837,
0.0083822226151824,
0.033573925495147705,
0.0020913337357342243,
0.004602059721946716,
0.0038871222641319036,
0.010802878066897392,
0.006817241199314594,
-0.01729361154139042,
-0.020851412788033485,
0.01594254933297634,
-0.03339378535747528,
0.006603322457522154,
-0.0194327961653471,
-0.01775522530078888,
-0.017439978197216988,
0.02431914210319519,
-0.02569272369146347,
-0.004849754739552736
] | 2024-07-22 | 1 | 39033659 | [
"immunogenic cell death",
"anti-tumor activity",
"vivo protective vaccine activity",
"intracellular reactive oxygen species",
"DHA",
"hepatocellular carcinoma",
"Cancer immunotherapies",
"immune responses",
"patients",
"absence",
"damage-associated molecular patterns",
"increasing tumor-infiltrating CD8",
"CDKs",
"HCC",
"ROS",
"ICD",
"release or surface expose",
"cyclin-dependent kinases",
"dihydroartemisinin",
"H22",
"both Hepa1-6 and H22 tumor bearing mice",
"a buildup",
"we",
"which"
] | [
"Chimeric antigen receptor cell",
"Cyclin-dependent kinase",
"Dihydroartemisinin",
"Immunogenic cell death",
"Reactive oxygen species",
"Tumor micro-environment"
] | 0 | 10.1016/j.intimp.2024.112637 | [
"Zhou",
"Lei",
"Fang",
"Chen",
"Zhou",
"Wang",
"Sun",
"Chen",
"Yin"
] | [
"State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.",
"State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China; Department of Laboratory Medicine, Xixi Hospital of Hangzhou, Hangzhou, Zhejiang 310023, China. Electronic address: [email protected].",
"State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.",
"State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.",
"State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.",
"State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.",
"State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.",
"State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China. Electronic address: [email protected].",
"State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Electronic address: [email protected]."
] | [
"39033659"
] | [] | 10.9033 | 4.002256 |
39033444 | 707 | Hu8F4-CAR T cells with mutated Fc spacer segment improve target specificity and mediate anti-leukemia activity in vivo. | Hu8F4 is a T-cell receptor-like antibody with high affinity for the leukemia-associated antigen PR1/HLA-A2 epitope. Adapted into a chimeric antigen receptor (CAR) format, Hu8F4-CAR is composed of the Hu8F4 single-chain variable fragment, the human IgG1 CH2CH3 extracellular spacer domain, a human CD28 costimulatory domain and the human CD3ζ signaling domain. We have demonstrated high efficacy of Hu8F4-CAR-T cells against PR1/HLA-A2-expressing cell lines and leukemic blasts from patients with acute myeloid leukemia in vitro. Previous studies have shown that modification of the Fc domains of IgG4 CH2CH3 spacer regions can eliminate activation-induced cell death and off-target killing mediated by mouse Fc gamma receptor-expressing cells.
We generated Hu8F4-CAR(PQ) with mutated Fc receptor binding sites on the CH2 domain of Hu8F4-CAR to prevent unwanted interactions with Fc gamma receptor-expressing cells in vivo.
The primary human T cells transduced with Hu8F4-CAR(PQ) can specifically lyse HLA-A2
Herein, we demonstrate that modification of the IgG1-based spacer can eliminate Fc receptor binding-induced adverse effects and Hu8F4-CAR(PQ)-T cells can kill leukemia in vivo. | [
0.009539208374917507,
-0.026126263663172722,
0.011796440929174423,
0.07703405618667603,
-0.05460581183433533,
-0.054125551134347916,
-0.03789268806576729,
0.050955820828676224,
0.010043483227491379,
-0.015536482445895672,
0.003072177292779088,
-0.022944526746869087,
-0.05950448662042618,
0.003124705981463194,
-0.013735499233007431,
-0.048962730914354324,
0.030640728771686554,
-0.03236967325210571,
0.009329093620181084,
0.036187756806612015,
-0.008458618074655533,
0.017745688557624817,
0.007534113246947527,
0.008776791393756866,
-0.013831551186740398,
-0.04490451514720917,
0.01991887576878071,
-0.011874482966959476,
-0.03023250587284565,
-0.023364756256341934,
0.01282300055027008,
-0.011364204809069633,
-0.000595825316850096,
-0.008152451366186142,
-0.014431878924369812,
0.009713303297758102,
-0.014455892145633698,
0.020327098667621613,
-0.02893579751253128,
-0.008332549594342709,
0.010511739179491997,
0.02421722188591957,
0.04084629938006401,
0.018249964341521263,
-0.035323284566402435,
0.030568689107894897,
0.0021941978484392166,
0.03210552781820297,
0.006753687281161547,
-0.021071504801511765,
0.017685655504465103,
0.01522431243211031,
-0.03508315607905388,
0.06608407944440842,
-0.0293200071901083,
0.034722957760095596,
0.02269238978624344,
0.018814271315932274,
-0.006741680670529604,
-0.005252867937088013,
-0.010883942246437073,
-0.026486460119485855,
0.01571658067405224,
-0.0340505912899971,
-0.07977155596017838,
0.0162808895111084,
-0.0895208790898323,
-0.054125551134347916,
0.04985121637582779,
0.02737494558095932,
-0.021419694647192955,
0.020903412252664566,
0.0282394178211689,
0.004085230175405741,
0.04331964999437332,
-0.011868479661643505,
0.0018355021020397544,
0.02521376684308052,
-0.028047312051057816,
-0.02953612618148327,
0.0045744976960122585,
0.02953612618148327,
0.006939788814634085,
-0.06425908207893372,
0.01309915166348219,
0.0035479371435940266,
0.004118248354643583,
-0.005706115160137415,
-0.0579676479101181,
-0.014647996984422207,
0.0041542681865394115,
0.028647640720009804,
-0.07871497422456741,
-0.013123164884746075,
-0.03722032159566879,
-0.023628899827599525,
-0.0021911964286118746,
-0.048098258674144745,
0.005949248094111681,
0.030688755214214325,
0.03635584935545921,
-0.0049857222475111485,
-0.017049308866262436,
-0.03018447943031788,
0.03815683349967003,
0.023424789309501648,
-0.03028053231537342,
-0.005790161434561014,
-0.0012411776697263122,
-0.002441833261400461,
0.06425908207893372,
-0.020195025950670242,
-0.07516103237867355,
0.07064656913280487,
-0.03760452941060066,
-0.05158016085624695,
-0.042815376073122025,
-0.0030676748137921095,
0.008512647822499275,
0.015116252936422825,
0.00735401501879096,
0.010619797743856907,
0.04471241310238838,
-0.048530496656894684,
-0.0000013982242990095983,
0.012642902322113514,
0.10210374742746353,
-0.051484107971191406,
-0.027470998466014862,
-0.04874661564826965,
0.04946700856089592,
-0.02356886863708496,
-0.011970535852015018,
0.015704574063420296,
-0.013231223449110985,
0.004034202545881271,
0.018309997394680977,
-0.03565946966409683,
-0.05945646017789841,
-0.0007781748427078128,
0.056766994297504425,
-0.006363474298268557,
-0.027086788788437843,
-0.01845407485961914,
-0.02775915525853634,
-0.027879221364855766,
-0.006837733089923859,
-0.03373841941356659,
0.018550127744674683,
0.050475556403398514,
-0.034290723502635956,
0.008182466961443424,
0.05004332214593887,
-0.023989098146557808,
-0.0035989650059491396,
-0.015800626948475838,
-0.012967079877853394,
0.018826277926564217,
-0.02000292018055916,
-0.031120991334319115,
-0.031385134905576706,
0.012462804093956947,
-0.04091833904385567,
-0.020543215796351433,
0.03873314708471298,
-0.027014749124646187,
-0.0011526292655616999,
-0.0032927978318184614,
-0.07727418839931488,
0.008818814530968666,
-0.016448980197310448,
-0.033546313643455505,
-0.05518212914466858,
-0.002363790525123477,
-0.03270585462450981,
0.031145004555583,
0.024577418342232704,
-0.011046030558645725,
-0.034626904875040054,
-0.053645290434360504,
0.037796635180711746,
0.012096604332327843,
0.02936803363263607,
-0.023857025429606438,
-0.03878117352724075,
-0.016701119020581245,
-0.012030567973852158,
0.007630165666341782,
-0.013303263112902641,
0.031000925227999687,
-0.02057923562824726,
0.04089432582259178,
0.07929129153490067,
0.0038961272221058607,
-0.02147972770035267,
-0.0190183836966753,
0.039093345403671265,
-0.0052648745477199554,
0.024877581745386124,
-0.03935748711228371,
-0.010511739179491997,
0.004763600882142782,
-0.06685250252485275,
0.021515747532248497,
-0.010271607898175716,
-0.011178103275597095,
0.007227946072816849,
-0.004913682583719492,
-0.025405870750546455,
0.027014749124646187,
0.05004332214593887,
0.026654552668333054,
0.02000292018055916,
-0.011640354990959167,
-0.019630717113614082,
-0.006321451161056757,
-0.013207211159169674,
0.019222494214773178,
0.018910324200987816,
0.029680203646421432,
-0.036019664257764816,
-0.019654730334877968,
0.0000112092448034673,
0.020303085446357727,
-0.07088670134544373,
-0.019546672701835632,
0.0269907359033823,
-0.040822286158800125,
-0.03092888556420803,
-0.0022332193329930305,
-0.0241691954433918,
0.004754595924168825,
-0.008176463656127453,
-0.05527817830443382,
-0.01996690221130848,
-0.030136452987790108,
-0.0009207527036778629,
0.022644363343715668,
0.050475556403398514,
-0.03340223804116249,
-0.04644135385751724,
0.01189249288290739,
0.053165026009082794,
0.0011623846367001534,
0.008632712997496128,
-0.008668732829391956,
0.004601512104272842,
-0.06858144700527191,
0.0401979461312294,
-0.0034188665449619293,
0.012859020382165909,
0.0011833960888907313,
0.007870296947658062,
-0.016316909343004227,
-0.005691107362508774,
0.018610160797834396,
0.061185404658317566,
-0.012066587805747986,
0.0026759610045701265,
-0.043127547949552536,
0.02131163515150547,
0.01282300055027008,
-0.023628899827599525,
-0.025790080428123474,
-0.021755877882242203,
0.004748592618852854,
0.019030390307307243,
0.010847922414541245,
-0.020122986286878586,
0.024013109505176544,
0.008746775798499584,
0.037916701287031174,
0.043079521507024765,
-0.015692567452788353,
-0.03832492604851723,
0.014455892145633698,
0.0019885858055204153,
0.02490159496665001,
0.018862297758460045,
-0.010349650867283344,
-0.011316178366541862,
-0.0115443030372262,
-0.010151542723178864,
-0.024277254939079285,
-0.03417065739631653,
-0.0026459447108209133,
0.0047515942715108395,
-0.018682200461626053,
-0.023268703371286392,
0.01758960261940956,
0.017133355140686035,
-0.007570133078843355,
0.004787614103406668,
-0.015932699665427208,
-0.042599257081747055,
0.047017671167850494,
-0.01888631097972393,
-0.01416773535311222,
-0.03196144849061966,
0.029560139402747154,
-0.001079089124687016,
-0.01589667983353138,
-0.03369039297103882,
-0.03657196834683418,
0.010967988520860672,
0.029440073296427727,
0.02996836230158806,
0.0016764153260737658,
-0.004721577744930983,
0.027302905917167664,
0.02320867031812668,
-0.009875391609966755,
0.00500073004513979,
0.024205215275287628,
0.010415686294436455,
-0.032417699694633484,
-0.021599791944026947,
-0.03469894453883171,
0.013735499233007431,
-0.05705514922738075,
0.0034368764609098434,
-0.02542988397181034,
-0.01971476338803768,
-0.024109162390232086,
0.011442246846854687,
-0.031769346445798874,
0.0019225496798753738,
-0.04142261669039726,
-0.016713125631213188,
-0.021731864660978317,
0.020891405642032623,
-0.018213944509625435,
0.026750605553388596,
-0.045985106378793716,
-0.007480083964765072,
0.007107880897819996,
-0.0687735453248024,
-0.0320575013756752,
-0.0012456801487132907,
-0.0019135447219014168,
-0.009124982170760632,
0.004787614103406668,
-0.05556633695960045,
0.01624486967921257,
-0.010325637646019459,
0.02737494558095932,
-0.00766618549823761,
0.012570863589644432,
0.003992179408669472,
0.047762077301740646,
0.00005281008270685561,
0.04171077162027359,
0.04994726926088333,
-0.015152272768318653,
0.0075281099416315556,
-0.037148281931877136,
0.008284523151814938,
-0.0385410413146019,
-0.023532848805189133,
0.04231110215187073,
0.013915597461163998,
0.0006175871822051704,
-0.023028573021292686,
0.013615434058010578,
0.03863709419965744,
0.04720977321267128,
0.0019195480272173882,
0.003947155084460974,
-0.002156677423045039,
-0.02360488660633564,
-0.02325669676065445,
-0.030568689107894897,
0.037364400923252106,
-0.03321013227105141,
-0.02845553494989872,
0.002741997130215168,
0.050475556403398514,
-0.01845407485961914,
0.030304545536637306,
-0.025742053985595703,
0.03935748711228371,
-0.0403660386800766,
-0.008800804615020752,
-0.004832638427615166,
0.00011856473429361358,
0.015644541010260582,
0.0069517954252660275,
0.001581863616593182,
-0.042647283524274826,
-0.005589051637798548,
0.0036439895629882812,
-0.017865754663944244,
0.00985738169401884,
-0.004361381288617849,
-0.010451706126332283,
0.04725779965519905,
0.03589960187673569,
0.08423799276351929,
0.026582513004541397,
0.0050307465717196465,
-0.016581052914261818,
-0.0019255513325333595,
-0.010937971994280815,
-0.044112082570791245,
0.0016704120207577944,
-0.031985461711883545,
0.010247594676911831,
0.02941606007516384,
0.02511771395802498,
-0.04271932318806648,
-0.014179741963744164,
-0.00589221715927124,
0.009443155489861965,
0.03028053231537342,
-0.014203755185008049,
-0.03599565103650093,
-0.05479791760444641,
0.028959810733795166,
-0.002458342118188739,
0.012030567973852158,
0.04360780864953995,
-0.0383729487657547,
-0.006441516801714897,
0.006591598968952894,
0.005967258010059595,
-0.03815683349967003,
0.012678922154009342,
0.013951617293059826,
0.02287248708307743,
-0.030568689107894897,
-0.0028740691486746073,
0.03383447229862213,
-0.028863757848739624,
-0.03309006616473198,
-0.04821832478046417,
0.007336005102843046,
-0.03373841941356659,
0.003607969731092453,
-0.023857025429606438,
0.06954196840524673,
-0.016821183264255524,
0.012642902322113514,
-0.007840280421078205,
-0.032849933952093124,
-0.013267243281006813,
0.015056219883263111,
0.013171191327273846,
0.01692924275994301,
-0.02400110475718975,
0.02780718170106411,
-0.041350577026605606,
-0.019738776609301567,
-0.023280709981918335,
0.030736781656742096,
0.008410591632127762,
0.006807717029005289,
0.02209206111729145,
-0.02607823722064495,
0.011820453219115734,
-0.007714211940765381,
0.06752486526966095,
-0.03200947493314743,
-0.003812081180512905,
-0.00848863460123539,
-0.01672513224184513,
0.007630165666341782,
0.03335421159863472,
-0.03191342204809189,
0.006045300513505936,
-0.0503314808011055,
-0.005144808907061815,
-0.029295993968844414,
0.02785520814359188,
0.027831194922327995,
-0.022212127223610878,
0.03899729251861572,
0.012012558057904243,
0.00363798625767231,
0.04478445276618004,
-0.026438433676958084,
0.004682556726038456,
-0.02091541886329651,
-0.004880664870142937,
-0.011442246846854687,
0.020507195964455605,
0.03724433481693268,
0.037100255489349365,
-0.021323641762137413,
-0.04612918570637703,
0.005351922009140253,
-0.02278844267129898,
-0.01706131547689438,
0.003863109042868018,
-0.011748414486646652,
-0.02412116900086403,
0.013531387783586979,
0.06584394723176956,
-0.022644363343715668,
0.008824817836284637,
-0.02230818010866642,
-0.0014985682209953666,
0.05743936076760292,
0.0009882895974442363,
-0.0019030390540137887,
0.03248973935842514,
0.042215049266815186,
0.04204695671796799,
-0.008326546289026737,
-0.023857025429606438,
0.038829199969768524,
0.012979086488485336,
-0.032249607145786285,
0.005601057782769203,
-0.01762562245130539,
-0.024013109505176544,
-0.06401894986629486,
-0.012132624164223671,
0.009593237191438675,
-0.013819544576108456,
0.030784808099269867,
-0.016665099188685417,
0.0054599810391664505,
0.0005335413152351975,
-0.003019648604094982,
0.016352927312254906,
-0.005486995913088322,
-0.04629727825522423,
-0.05090779438614845,
-0.024853568524122238,
-0.06041698530316353,
0.008632712997496128,
-0.01584865339100361,
-0.0028395503759384155,
0.005441971123218536,
-0.020159006118774414,
-0.01788976788520813,
-0.017865754663944244,
0.045720960944890976,
-0.0018760242965072393,
-0.030376585200428963,
0.020243052393198013,
-0.018634174019098282,
0.0171933863312006,
-0.03373841941356659,
0.0383729487657547,
0.022272160276770592,
-0.008662729524075985,
-0.024457352235913277,
0.023664919659495354,
-0.024661464616656303,
0.033066052943468094,
-0.020591242238879204,
-0.0011286161607131362,
-0.00892087072134018,
0.00567309744656086,
-0.002015600446611643,
-0.0027254880405962467,
-0.015512469224631786,
-0.011616341769695282,
-0.008314539678394794,
0.009148995392024517,
-0.022428244352340698,
-0.00499172555282712,
-0.010487725958228111,
-0.016256876289844513,
0.0031787354964762926,
-0.008962893858551979,
-0.020591242238879204,
-0.02634238265454769,
0.026702579110860825,
0.009329093620181084,
0.018958350643515587,
-0.016436973586678505,
0.005682102404534817,
0.06738078594207764,
-0.00213416526094079,
-0.015008194372057915,
0.022800447419285774,
-0.015008194372057915,
0.03863709419965744,
-0.020735321566462517,
-0.005291889421641827,
-0.013399315997958183,
0.05667094141244888,
-0.00039921796997077763,
-0.011676374822854996,
-0.0363798625767231,
-0.015596515499055386,
-0.01130417175590992,
0.014323820360004902,
0.025670014321804047,
-0.014455892145633698,
0.030592702329158783,
0.016989275813102722,
-0.030160466209053993,
-0.014575958251953125,
-0.015752600505948067,
0.014215761795639992,
-0.0212636087089777,
0.003812081180512905,
0.009779339656233788,
-0.018334010615944862,
-0.025621987879276276,
-0.0323936864733696,
-0.048410430550575256,
0.005111790727823973,
0.013675466179847717,
-0.00754611985757947,
-0.013735499233007431,
-0.01961871050298214,
0.026486460119485855,
0.014563951641321182,
-0.044976554811000824,
0.027446985244750977,
0.005429964512586594,
0.020303085446357727,
-0.013027111999690533,
-0.02199600823223591,
0.014419873245060444,
-0.02212808094918728,
-0.00553202023729682,
-0.020675288513302803,
0.019258514046669006,
-0.019438613206148148,
-0.002423823345452547,
-0.017337465658783913,
-0.018358023837208748,
0.015608522109687328,
-0.0069998218677937984,
0.001817492302507162,
0.0059252348728477955,
-0.050523582845926285,
-0.019690750166773796,
0.008806807920336723,
-0.0009327592561021447,
-0.03169730678200722,
0.0049467007629573345,
-0.02031509205698967,
0.0012914551189169288,
0.006993818562477827,
0.029247969388961792,
0.005033748224377632,
0.010739863850176334,
-0.002342779189348221,
0.04048610478639603,
-0.03561144322156906,
0.004271332174539566,
0.0014520427212119102,
0.009191017597913742,
-0.009641263633966446,
-0.0058411890640854836,
-0.023376762866973877,
0.006825726479291916,
0.011754417791962624,
0.029704216867685318,
-0.03162526711821556,
-0.02759106457233429,
0.019006377086043358,
0.04471241310238838,
0.039477553218603134,
-0.021971996873617172,
0.0380367673933506,
-0.009917414747178555,
-0.01845407485961914,
-0.01028961781412363,
-0.022380219772458076,
-0.0015698571223765612,
0.03565946966409683,
0.00907095242291689,
0.013747505843639374,
0.09393928945064545,
0.01290704682469368,
0.014323820360004902,
-0.008902860805392265,
-0.016737138852477074,
-0.015080233104526997,
-0.010613794438540936,
-0.009887398220598698,
-0.06401894986629486,
-0.015776613727211952,
-0.0034158648923039436,
-0.004112245049327612,
-0.02235620655119419,
-0.09197021275758743,
-0.00790631677955389,
0.010535752400755882,
-0.006705661304295063,
-0.02737494558095932,
-0.006669641472399235,
-0.011586326174438,
-0.02455340512096882,
0.006705661304295063,
-0.012859020382165909,
-0.02044716291129589,
0.007462074048817158,
0.014503918588161469,
-0.0013770017540082335,
-0.006549575831741095,
-0.017697662115097046,
-0.001674914499744773,
0.016100790351629257,
-0.00980935525149107,
0.04113445803523064,
-0.04444826766848564,
0.02122758887708187,
-0.02373695932328701,
-0.047497931867837906,
0.005685104057192802,
0.019522659480571747,
0.055374231189489365,
-0.007720214780420065,
-0.02576606720685959,
-0.013747505843639374,
-0.032417699694633484,
0.009142992086708546,
0.0343867726624012,
0.010103516280651093,
0.03184138610959053,
-0.008830821141600609,
0.027903234586119652,
-0.0029836290050297976,
-0.006789707113057375,
-0.0006194632151164114,
-0.010019470006227493,
0.009581231512129307,
0.009779339656233788,
-0.01538039743900299,
0.0445203073322773,
-0.045504845678806305,
0.00700582517310977,
-0.008368569426238537,
-0.013435334898531437,
-0.01870621368288994,
-0.009821361862123013,
-0.02109551802277565,
0.03880518674850464,
-0.014371846802532673,
-0.025453897193074226,
-0.037316374480724335,
-0.009046939201653004,
0.024265248328447342,
-0.029271980747580528,
-0.013279249891638756,
0.033546313643455505,
-0.039477553218603134,
0.031289082020521164,
0.003421868197619915,
-0.0022542306687682867,
0.015428423881530762,
-0.031217044219374657,
-0.026822645217180252,
0.008386578410863876,
-0.020219039171934128,
-0.0018460078863427043,
-0.004772605840116739,
-0.03280190750956535,
-0.01018155924975872,
0.026174290105700493,
0.0005601808661594987,
-0.0009387625614181161,
-0.021071504801511765,
0.02802330069243908,
0.012750961817800999,
-0.02554995007812977,
0.0074260542169213295,
0.0327298678457737,
-0.02169584482908249,
0.020771341398358345,
0.01524832472205162,
0.004325361456722021,
-0.008692746050655842,
-0.007882303558290005,
0.016773156821727753,
-0.010325637646019459,
-0.004577499348670244,
-0.0020891407039016485,
-0.030784808099269867,
-0.02165982499718666,
-0.023664919659495354,
0.020867392420768738,
-0.004469440318644047,
0.001506072236225009,
-0.01052374579012394,
-0.016100790351629257,
0.004130254965275526,
-0.04094235226511955,
-0.014083689078688622,
0.011424236930906773,
-0.02352084219455719,
0.006825726479291916,
-0.021635811775922775,
0.02442133240401745,
-0.04101439192891121,
0.005670095793902874,
-0.014419873245060444,
0.05042753368616104,
0.03498710319399834,
-0.11094056814908981,
-0.004358379635959864,
-0.00735401501879096,
-0.034939076751470566,
0.0017019292572513223,
0.01772167533636093,
-0.020159006118774414,
0.017529571428894997,
0.012096604332327843,
-0.014203755185008049,
0.037148281931877136,
0.0011646358761936426,
0.023977091535925865,
0.0008021879475563765,
-0.006465530022978783,
-0.013483361341059208,
0.009587233886122704,
-0.024397321045398712,
0.0066336216405034065,
0.011874482966959476,
0.004496454726904631,
-0.0031697305385023355,
0.019654730334877968,
-0.01979880966246128,
-0.006105333101004362,
0.005315902177244425,
-0.02893579751253128,
-0.022500284016132355,
-0.012726948596537113,
0.0036860124673694372,
0.0025979182682931423,
0.007257962599396706,
-0.022728409618139267,
0.022032028064131737,
0.002126661129295826,
-0.03998182713985443,
0.0171933863312006,
-0.01509223971515894,
0.0016704120207577944,
0.013327276334166527,
0.009245047345757484,
-0.009215030819177628,
-0.00766618549823761,
0.022812454029917717,
-0.027014749124646187,
-0.01649700663983822,
-0.028911784291267395,
-0.0007901813951320946,
0.01996690221130848,
-0.010841919109225273,
0.010637807659804821,
0.00907095242291689,
-0.031000925227999687,
0.02759106457233429,
-0.04802621901035309,
-0.031000925227999687,
0.024289261549711227,
0.003646991215646267,
-0.0018264972604811192,
-0.00021480477880686522,
-0.03323414549231529,
0.08154851943254471,
0.050091348588466644,
-0.02975224331021309,
-0.010577775537967682,
-0.01883828453719616,
-0.051484107971191406,
0.04946700856089592,
-0.04708971083164215,
-0.012192657217383385,
0.0002138667623512447,
0.025694027543067932,
-0.025405870750546455,
0.026750605553388596,
-0.001254684990271926,
-0.03143316134810448,
0.017133355140686035,
0.011106063611805439,
-0.01814190484583378,
0.009773336350917816,
0.017013289034366608,
-0.01823795773088932,
-0.047065697610378265,
0.02217610739171505,
-0.0539814718067646,
-0.000734651111997664,
0.03208151459693909,
-0.0057871597819030285,
0.035755522549152374,
-0.00416927644982934,
-0.019114436581730843,
0.0008006871212273836,
0.0073239984922111034,
0.0032117534428834915,
-0.005477990955114365,
-0.011706391349434853,
-0.03313809260725975,
0.0008231994579546154,
0.0061203413642942905,
-0.016821183264255524,
0.04877062886953354,
-0.03719630837440491,
-0.0008532158099114895,
-0.0362117700278759,
-0.04720977321267128,
0.015188292600214481,
0.040606170892715454,
-0.02214008755981922,
0.0009635260794311762,
-0.012738955207169056,
0.05037950724363327,
0.014635990373790264,
0.01772167533636093,
-0.00039058824768289924,
-0.0080563984811306,
0.0032297633588314056,
-0.005712118465453386,
-0.007041844539344311,
-0.021551767364144325,
-0.010115522891283035,
0.01915045641362667,
0.020591242238879204,
0.00922703742980957,
-0.004607515409588814,
-0.0005339165218174458,
0.010787890292704105,
0.005138805601745844,
0.03513117879629135,
0.010499732568860054,
0.010349650867283344,
0.009653270244598389,
-0.004490451421588659,
0.00416927644982934,
-0.031024938449263573,
0.0016148816794157028,
0.003157723927870393,
-0.006243408657610416,
0.005496000871062279,
-0.013735499233007431,
0.023172652348876,
0.0033858485985547304,
-0.004391397349536419,
0.020122986286878586,
-0.029223956167697906,
0.012012558057904243,
0.009275063872337341,
-0.06243408843874931,
0.0121686439961195,
-0.03157724067568779,
-0.0056550875306129456,
-0.044688399881124496,
0.020291078835725784,
0.015968717634677887,
0.006861746311187744,
0.011406227014958858,
0.03657196834683418,
0.04315156117081642,
-0.03582756221294403,
-0.030304545536637306,
0.011214122176170349,
-0.017961805686354637,
0.03184138610959053,
-0.02179189771413803,
-0.03335421159863472,
-0.0002952862123493105,
0.008704752661287785,
-0.0006776199443265796,
0.023833012208342552,
0.03546736389398575,
0.03971768543124199,
-0.012072591111063957,
-0.03006441332399845,
0.04509662091732025,
-0.011670371517539024,
-0.01403566263616085,
0.008518651127815247,
0.01724141277372837,
0.012582870200276375,
0.03174533322453499,
0.03534729778766632,
-0.03143316134810448,
-0.004586504306644201,
0.06915775686502457,
0.027182841673493385,
0.02386903204023838,
-0.0002294377627549693,
0.023400776088237762,
-0.03935748711228371,
0.061185404658317566,
0.005489997565746307,
0.0200989730656147,
0.008038388565182686,
-0.02953612618148327,
0.04447228088974953,
0.03143316134810448,
-0.019822822883725166,
-0.036187756806612015,
-0.0008449613233096898,
-0.0619538240134716,
-0.04838641732931137,
-0.014203755185008049,
0.025237778201699257,
0.026438433676958084,
-0.04161471873521805,
-0.026222316548228264,
0.005853195674717426,
0.004772605840116739,
-0.028215404599905014,
0.02542988397181034,
0.050091348588466644,
-0.026822645217180252,
0.02634238265454769,
-0.0075761363841593266,
0.024325281381607056,
0.02651047334074974,
-0.011448250152170658,
0.005907224956899881,
0.023580875247716904,
-0.0071018775925040245,
-0.015044213272631168,
-0.02265636995434761,
-0.019678743556141853,
-0.01067382749170065,
0.008332549594342709,
0.0023667921777814627,
-0.046201225370168686,
0.03813282027840614,
-0.011598332785069942,
0.011490273289382458,
0.04091833904385567,
-0.05172424018383026,
0.013027111999690533,
0.002979126526042819,
-0.004151266533881426,
0.01802183873951435,
-0.011316178366541862,
-0.024637451395392418,
-0.05287686735391617,
-0.02352084219455719,
-0.0086387163028121,
0.04574497416615486,
0.01740950532257557,
0.010583778843283653,
-0.0010445703519508243,
0.03265783190727234,
-0.015344377607107162,
0.02876770682632923,
-0.026222316548228264,
-0.009647266939282417,
-0.017661642283201218,
0.001010801875963807,
-0.014539938420057297,
0.0027600068133324385,
0.046849578619003296,
-0.008212483488023281,
-0.000806690426543355,
0.03191342204809189,
0.029271980747580528,
0.0309769120067358,
0.001356740714982152,
0.013735499233007431,
0.014936154708266258,
0.011058037169277668,
-0.008956890553236008,
0.037532489746809006,
-0.015524475835263729,
-0.0030796814244240522,
-0.03400256484746933,
-0.013003099709749222,
0.007161910180002451,
0.0035269255749881268,
0.011634351685643196,
0.03724433481693268,
-0.020471176132559776,
-0.027567051351070404,
-0.007594146300107241,
0.02338876947760582,
0.00727597251534462,
0.009785342030227184,
0.018430061638355255,
-0.030112439766526222,
0.010037479922175407,
-0.04063018411397934,
0.029055863618850708,
0.023808998987078667,
0.016881216317415237,
0.007251959294080734,
-0.006000276189297438,
0.032201580703258514,
0.016617072746157646,
-0.006375480908900499,
-0.0382048599421978,
-0.011418233625590801,
-0.02071130834519863,
0.01403566263616085,
-0.0035479371435940266,
-0.009713303297758102,
-0.02996836230158806,
-0.0046195220202207565,
-0.016653092578053474,
0.029344020411372185,
0.017445525154471397,
-0.0021956986747682095,
-0.0579676479101181,
0.025357844308018684,
-0.03412263095378876,
0.008482631295919418,
-0.010589782148599625,
0.033162105828523636,
0.01775769516825676,
-0.0026579510886222124,
0.011790437623858452,
0.01918647438287735,
-0.021299628540873528,
0.0325617790222168,
0.051051873713731766,
-0.02212808094918728,
0.0037940714973956347,
0.013399315997958183,
0.013531387783586979,
-0.039741698652505875,
0.028839746490120888,
0.015020200982689857,
0.016653092578053474,
0.0010498231276869774,
-0.023700939491391182,
0.0014197751879692078,
-0.015296351164579391,
0.0006719919038005173,
-0.020351111888885498,
0.008386578410863876,
-0.021984003484249115,
0.04478445276618004,
0.01247481070458889,
-0.02330472320318222,
0.005153813865035772,
-0.01692924275994301,
-0.011922509409487247,
-0.012216669507324696,
0.01664108596742153,
-0.023076599463820457,
0.0009897904237732291,
0.01832200400531292,
-0.002878571627661586,
0.0007552873576059937,
-0.005258871242403984,
0.005658089183270931,
-0.03729236125946045,
-0.01607677713036537,
-0.05916830524802208,
0.05090779438614845,
0.0023262700997292995,
-0.0071859234012663364,
0.02074732817709446,
-0.006225398741662502,
-0.013903590850532055,
0.0064475201070308685,
0.056334756314754486,
-0.0049376958049833775,
0.010043483227491379,
-0.018862297758460045,
0.01584865339100361,
0.04262327030301094,
0.022056041285395622,
0.004766602534800768,
0.020807359367609024,
-0.020639268681406975,
-0.00027127310750074685,
-0.009058945812284946,
0.00046600442146882415,
0.009587233886122704,
0.017769701778888702,
-0.012114614248275757,
0.0024298266507685184,
0.014059675857424736,
0.0028500559274107218,
0.030304545536637306,
0.03313809260725975,
0.008524654433131218,
0.027783168479800224,
0.02910389006137848,
0.0076601821929216385,
0.0020276070572435856,
-0.03748446702957153,
-0.022584330290555954,
-0.005060763098299503,
0.0025243782438337803,
-0.02101147174835205,
0.021155551075935364,
-0.015176285989582539,
-0.0342186838388443,
-0.0073900348506867886,
0.023676926270127296,
0.014563951641321182,
-0.008902860805392265,
-0.019126443192362785,
0.02802330069243908,
0.005616066046059132,
-0.01845407485961914,
0.0031787354964762926,
-0.005009735003113747,
-0.017637629061937332,
0.03515519201755524,
0.00161338085308671,
0.028095338493585587,
0.04310353472828865,
-0.005414956249296665,
0.009905408136546612,
-0.006849739700555801,
0.0073720249347388744,
-0.017685655504465103,
0.007804261054843664,
-0.02347281575202942,
-0.009959437884390354,
-0.010901952162384987,
0.0032327650114893913,
0.025093700736761093,
-0.013663459569215775,
-0.007125890348106623,
0.02053120918571949,
-0.010703844018280506,
0.014684016816318035,
-0.00754611985757947,
0.012871026992797852,
0.01533237099647522,
-0.002021603751927614,
-0.010907955467700958,
0.005580046679824591,
-0.015824640169739723,
0.03018447943031788,
0.010847922414541245,
-0.014575958251953125,
0.027038762345910072,
-0.016100790351629257,
0.011100060306489468,
-0.005595054943114519,
-0.01659305952489376,
0.029608165845274925,
-0.022344199940562248,
0.009197020903229713,
-0.000690752116497606,
-0.001370998565107584,
0.04898674413561821,
0.037532489746809006,
-0.010277611203491688,
-0.03236967325210571,
-0.02538185752928257,
-0.005462982691824436,
0.05388541892170906,
0.027182841673493385,
0.018045851960778236,
0.03109697811305523,
-0.03061671555042267,
0.005291889421641827,
-0.01479207631200552,
-0.006909772288054228,
-0.0032657829578965902,
-0.01416773535311222,
0.013063131831586361,
-0.0027299905195832253,
-0.025790080428123474,
-0.012762968428432941,
-0.01290704682469368,
0.02775915525853634,
-0.01295507326722145,
0.009503188543021679,
-0.001309464918449521,
0.026222316548228264,
-0.004352376330643892,
-0.0003538181772455573,
0.005688105709850788,
0.013039118610322475,
0.00657358905300498,
-0.00026264338521286845,
-0.0014122710563242435,
0.004772605840116739,
0.027495011687278748,
-0.010847922414541245,
-0.00016593433974776417,
-0.00883682444691658,
-0.03777262195944786,
0.0027705125976353884,
0.008194473572075367,
-0.011910502798855305,
-0.015776613727211952,
0.028575601056218147,
-0.02516574040055275,
-0.027903234586119652,
0.017901774495840073,
0.011766424402594566,
-0.007888306863605976,
-0.03563545644283295,
-0.002588913543149829,
0.013279249891638756,
-0.012066587805747986,
0.02157578058540821,
0.014179741963744164,
-0.03076079487800598,
0.0040492108091712,
0.00985137838870287,
-0.007125890348106623,
-0.008620706386864185,
0.018297990784049034,
-0.019762789830565453,
-0.013651452958583832,
0.010667824186384678,
-0.02672659233212471,
-0.008374571800231934,
-0.013831551186740398,
0.01749355159699917,
-0.016773156821727753,
-0.010025473311543465,
0.004721577744930983,
0.009683286771178246,
0.013675466179847717,
-0.022776436060667038,
-0.008800804615020752,
0.022248147055506706,
0.0010190564207732677,
0.0046585435047745705,
0.030040401965379715,
0.00931108370423317,
0.004733584355562925,
0.005763146560639143,
-0.017649635672569275,
-0.01906641013920307,
0.0015165780205279589,
0.0241691954433918,
-0.021803904324769974,
-0.008008372038602829,
0.03885321319103241,
-0.04536076635122299,
-0.009148995392024517,
0.00024125671188812703,
-0.010529749095439911,
0.045720960944890976,
0.011916506104171276,
-0.015596515499055386,
0.011814449913799763,
-0.017781708389520645,
-0.015692567452788353,
0.0031877404544502497,
0.02603021077811718,
-0.006609608419239521,
0.012414777651429176,
0.037148281931877136,
-0.0006348466267809272,
-0.016256876289844513,
0.025285804644227028,
-0.018610160797834396,
-0.0009500187006779015,
0.027687115594744682,
0.012402771972119808,
0.026006199419498444,
-0.017445525154471397,
-0.06886959820985794,
-0.008758782409131527,
-0.03066474199295044,
-0.047065697610378265,
0.02651047334074974,
0.03522723168134689,
0.054557785391807556,
0.0019480636110529304,
0.027495011687278748,
-0.01770966872572899,
-0.0033858485985547304,
-0.017637629061937332,
0.003532928880304098,
-0.02867165394127369,
-0.016352927312254906,
-0.006831729784607887,
-0.022164100781083107,
-0.02109551802277565,
-0.015068226493895054,
-0.005658089183270931,
0.014491911977529526,
0.015104246325790882,
0.012738955207169056,
0.01431181374937296,
-0.005258871242403984,
-0.024637451395392418,
0.013711486011743546,
-0.02338876947760582,
-0.006627618335187435,
-0.019906869158148766,
0.0019555676262825727,
-0.02554995007812977,
0.029560139402747154,
-0.020951438695192337,
0.026414422318339348,
-0.04514464735984802,
-0.002105649560689926,
0.014455892145633698,
-0.010998004116117954,
-0.018093878403306007,
-0.0009582731872797012,
0.020855385810136795,
-0.001207409193739295,
-0.0242532417178154,
-0.011448250152170658,
-0.028647640720009804,
0.025309817865490913,
0.027519024908542633,
-0.01401165034621954,
0.0041902875527739525,
-0.022812454029917717,
0.00794833991676569,
-0.024181202054023743,
-0.04051011800765991,
-0.0007541617378592491,
-0.004661545157432556,
-0.0040131909772753716,
-0.03395453840494156,
-0.03544335067272186,
0.01784174144268036,
0.0028530575800687075,
-0.05883212015032768,
0.008950887247920036,
0.025357844308018684,
0.004043207503855228,
0.056286729872226715,
0.03690814971923828,
-0.02079535275697708,
0.009263057261705399,
0.000418353418353945,
0.008950887247920036,
-0.0121266208589077,
-0.008182466961443424,
0.027567051351070404,
-0.004151266533881426,
0.016172830015420914,
0.03546736389398575,
0.002320266794413328,
-0.011862476356327534,
0.011256145313382149,
-0.005577045027166605,
0.012510830536484718,
-0.00029434819589369,
-0.023893045261502266,
0.02174387127161026,
-0.027470998466014862,
0.019222494214773178,
0.025694027543067932,
-0.001655403757467866,
-0.011532296426594257,
0.024589424952864647,
-0.0006843736628070474,
0.015476449392735958,
0.007726218085736036,
-0.013651452958583832,
0.008602696470916271,
0.023532848805189133,
-0.020122986286878586,
0.01632891595363617,
0.0343867726624012,
0.018418055027723312,
0.0011556309182196856,
0.03369039297103882,
0.008092418313026428,
0.028863757848739624,
0.053213052451610565,
-0.024241235107183456,
0.0020110979676246643,
-0.0022752422373741865,
0.017529571428894997,
0.012114614248275757,
0.03282592073082924,
0.023376762866973877,
-0.003400856861844659,
-0.01948663964867592,
-0.027951261028647423,
-0.0002560772991273552,
-0.014431878924369812,
-0.0009500187006779015,
0.11132477968931198,
0.00414826488122344,
0.015944704413414,
0.02031509205698967,
-0.020843379199504852,
-0.024073142558336258,
0.005054759792983532,
0.0005583048332482576,
0.015524475835263729,
-0.010817905887961388,
0.02732691913843155,
0.026870669797062874,
0.016617072746157646,
0.010841919109225273,
0.007678192108869553,
0.00829652976244688,
-0.017469538375735283,
0.020807359367609024,
-0.028095338493585587,
0.0002999762655235827,
-0.007642172276973724,
0.025670014321804047,
-0.022104067727923393,
0.01867019385099411,
0.009124982170760632,
-0.025790080428123474,
0.006507552694529295,
-0.011922509409487247,
0.008614703081548214,
-0.000134886140585877,
0.017349472269415855,
-0.005231856368482113,
0.011388218030333519,
-0.05023542791604996,
0.02027907222509384,
-0.002970121568068862,
-0.006549575831741095,
-0.012654908932745457,
0.01754157803952694,
0.015104246325790882,
-0.015344377607107162,
0.011214122176170349,
-0.005520013626664877,
0.00911897886544466,
0.015236318111419678,
-0.014936154708266258,
-0.000024763519832049496,
-0.0115022799000144,
0.023700939491391182,
-0.015968717634677887,
-0.020255059003829956,
-0.017913781106472015,
0.01659305952489376,
-0.0013492365833371878,
-0.0201830193400383,
-0.02335274964570999,
0.02053120918571949,
-0.009683286771178246,
-0.029055863618850708,
-0.04440024122595787,
-0.03001638874411583,
-0.022992553189396858,
0.007552123162895441,
0.01823795773088932,
0.026318369433283806
] | 2024-07-21 | 23 | 39033444 | [
"mutated Fc receptor binding sites",
"mouse Fc gamma receptor-expressing cells",
"Fc gamma receptor-expressing cells",
"IgG4 CH2CH3 spacer regions",
"Fc",
"Fc receptor binding-induced adverse effects",
"acute myeloid leukemia",
"the human IgG1 CH2CH3 extracellular spacer domain",
"Hu8F4-CAR(PQ)-T cells",
"The primary human T cells",
"activation-induced cell death",
"high affinity",
"high efficacy",
"leukemia",
"leukemic blasts",
"unwanted interactions",
"a chimeric antigen receptor",
"a human CD28 costimulatory domain",
"Hu8F4-CAR-T cells",
"the Fc domains",
"CAR",
"the human CD3ζ signaling domain",
"a T-cell receptor-like antibody",
"PR1/HLA-A2-expressing cell lines",
"Previous studies",
"Hu8F4-CAR",
"the Hu8F4 single-chain variable fragment",
"patients",
"the CH2 domain",
"killing"
] | [
"AML",
"CAR-T cell",
"Hu8F4",
"PR1"
] | 0 | 10.1016/j.jcyt.2024.06.010 | [
"He",
"Vedia",
"Lu",
"Li",
"Cox",
"St John",
"Sergeeva",
"Clise-Dwyer",
"Alatrash",
"Shpall",
"Ma",
"Molldrem"
] | [
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.",
"Department of Hematopoietic Biology and Malignancy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA. Electronic address: [email protected]."
] | [
"39033444",
"25317870",
"24553386",
"23515080",
"12509765",
"11753365",
"36209106",
"8839835",
"9326217",
"10973322",
"27654852",
"20735170",
"21296998",
"27055866",
"30713535",
"27265873",
"32739874",
"32637585",
"21540550",
"25652098",
"25212991",
"22495388",
"20555360"
] | [] | 8.3213 | 5.384812 |
39032532 | 708 | Molecular mechanism of co-stimulatory domains in promoting CAR-T cell anti-tumor efficacy. | Chimeric antigen receptor (CAR)-engineered T cells have been defined as 'living drug'. Adding a co-stimulatory domain (CSD) has enhanced the anti-hematological effects of CAR-T cells, thereby elevating their viability for medicinal applications. Various CSDs have helped prepare CAR-T cells to study anti-tumor efficacy. Previous studies have described and summarized the anti-tumor efficacy of CAR-T cells obtained from different CSDs. However, the underlying molecular mechanisms by which different CSDs affect CAR-T function have been rarely reported. The role of CSDs in T cells has been significantly studied, but whether they can play a unique role as a part of the CAR structure remains undetermined. Here, we summarized the effects of CSDs on CAR-T signaling pathways based on the limited references and speculated the possible mechanism depending on the specific characteristics of CAR-T cells. This review will help understand the molecular mechanism of CSDs in CAR-T cells that exert different anti-tumor effects while providing potential guidance for further interventions to enhance anti-tumor efficacy in immunotherapy. | [
0.023616749793291092,
-0.014277398586273193,
0.03752439096570015,
0.07204300910234451,
-0.024785658344626427,
-0.014193904586136341,
0.009691216051578522,
-0.017426298931241035,
0.00725797563791275,
-0.02938973158597946,
-0.003894377965480089,
-0.014217760413885117,
-0.04105497524142265,
-0.003909287508577108,
0.03990992158651352,
-0.058493200689554214,
0.03490030765533447,
-0.004296936094760895,
0.047209642827510834,
0.02236434631049633,
0.053388167172670364,
0.012201987206935883,
-0.010120611637830734,
0.032204657793045044,
-0.034280069172382355,
-0.020408211275935173,
0.017020758241415024,
0.046541694551706314,
-0.02664637193083763,
-0.01209463831037283,
0.014158121310174465,
-0.018118102103471756,
-0.04957131668925285,
-0.035639822483062744,
-0.025429751724004745,
0.06388449668884277,
0.006852435413748026,
0.013776436448097229,
-0.019513636827468872,
-0.025405896827578545,
0.03547283262014389,
0.0357590988278389,
0.004866481758654118,
0.0717567503452301,
-0.07247240841388702,
-0.01176066417247057,
-0.028125401586294174,
-0.03230007737874985,
-0.009273748844861984,
0.025811437517404556,
-0.031107313930988312,
0.017199672758579254,
-0.0032323934137821198,
0.001754855620674789,
-0.0426771342754364,
0.01574449986219406,
-0.024201203137636185,
-0.012005181051790714,
-0.02349747158586979,
0.007854358293116093,
0.0008915918879210949,
-0.008868208155035973,
-0.005439009051769972,
0.001972535392269492,
-0.043846044689416885,
-0.010275671258568764,
-0.04534892737865448,
-0.010120611637830734,
-0.014873780310153961,
0.03773908689618111,
0.027362031862139702,
0.0007458509062416852,
0.031894538551568985,
-0.009398989379405975,
0.023127716034650803,
-0.02341397851705551,
0.02938973158597946,
0.03129815682768822,
0.022781813517212868,
0.0015200299676507711,
0.01979990117251873,
-0.002485424280166626,
0.01150421891361475,
-0.061976075172424316,
-0.015661004930734634,
-0.023712169378995895,
0.016794132068753242,
-0.03995763137936592,
-0.033969949930906296,
0.004869463387876749,
-0.0011547456961125135,
0.011015186086297035,
-0.06569749861955643,
0.04971444979310036,
-0.011384942568838596,
0.03828775882720947,
-0.0012755132047459483,
-0.04885565862059593,
0.012846079654991627,
0.004362538456916809,
0.04363134875893593,
-0.010472477413713932,
-0.05057324096560478,
-0.02303229458630085,
0.025787580758333206,
0.0290080476552248,
-0.019895322620868683,
-0.03170369565486908,
0.014158121310174465,
-0.014026917517185211,
0.0782930999994278,
-0.015732571482658386,
-0.030916471034288406,
0.06674713641405106,
-0.01830894500017166,
-0.051670584827661514,
-0.043488215655088425,
0.011468436568975449,
-0.013931496068835258,
0.0375005342066288,
-0.02628854289650917,
0.03878872096538544,
0.027576729655265808,
0.00225730799138546,
0.0010965984547510743,
-0.020766040310263634,
0.06980061531066895,
-0.05081179365515709,
-0.023425906896591187,
-0.03859787806868553,
-0.00004307466224418022,
0.03308730199933052,
0.018917255103588104,
-0.01808231882750988,
-0.03375525400042534,
-0.008021345362067223,
-0.06894182413816452,
-0.024809513241052628,
-0.04155593737959862,
0.0021917058620601892,
0.01944207027554512,
-0.022972656413912773,
0.04565904662013054,
0.027815282344818115,
-0.025024211034178734,
-0.06364594399929047,
0.005039432551711798,
0.0375005342066288,
-0.05725272372364998,
0.03747668117284775,
-0.027433596551418304,
0.06207149475812912,
0.08707185089588165,
-0.027338175103068352,
0.007979598827660084,
-0.043201953172683716,
-0.006506533827632666,
0.03959980234503746,
-0.03435163572430611,
-0.04220002889633179,
0.005951897706836462,
-0.004028564319014549,
-0.027886848896741867,
-0.03000997006893158,
0.00954212062060833,
-0.032180801033973694,
-0.019346650689840317,
0.027051912620663643,
-0.07070711255073547,
-0.024165421724319458,
-0.002306509530171752,
-0.07585985958576202,
-0.05892259627580643,
-0.029795272275805473,
-0.05768211930990219,
-0.005304822698235512,
0.00502154091373086,
0.021708324551582336,
-0.0036498610861599445,
-0.025453606620430946,
0.029103469103574753,
0.01127163041383028,
0.007401107344776392,
-0.008319536224007607,
-0.02013387531042099,
0.006858399137854576,
-0.015470162965357304,
0.004771060310304165,
-0.044513992965221405,
-0.022924944758415222,
-0.008057128638029099,
-0.02764829434454441,
0.057491276413202286,
0.01226162537932396,
-0.037047285586595535,
0.006834543775767088,
0.025405896827578545,
0.031560566276311874,
-0.009136580862104893,
-0.022865306586027145,
0.02200651541352272,
-0.041412804275751114,
-0.029461298137903214,
0.0013992625754326582,
-0.041078828275203705,
-0.02272217534482479,
-0.02120736427605152,
0.03368368744850159,
0.00019568802963476628,
0.004642838146537542,
0.04372676834464073,
-0.015374742448329926,
-0.022746030241250992,
0.030200812965631485,
-0.034256212413311005,
-0.018165811896324158,
0.022710246965289116,
0.03683258593082428,
0.021756036207079887,
0.0028417627327144146,
-0.020873388275504112,
0.0025450624525547028,
0.03614078089594841,
0.005185546353459358,
-0.05057324096560478,
0.03490030765533447,
-0.038741011172533035,
-0.027195043861865997,
0.009070978499948978,
0.00969718024134636,
0.004240280017256737,
0.00031626911368221045,
0.0170803964138031,
-0.03203767165541649,
-0.06273944675922394,
0.01517197210341692,
0.019919177517294884,
0.007007495034486055,
0.06288257241249084,
-0.03280103951692581,
0.004264135379344225,
-0.001205438282340765,
0.040387026965618134,
0.009548084810376167,
-0.009840312413871288,
0.009828384034335613,
-0.0032025743275880814,
-0.07237698882818222,
-0.0005743909277953207,
-0.015231610275804996,
0.006733159068971872,
0.027529017999768257,
-0.00954212062060833,
-0.0034441091120243073,
0.02862636186182499,
0.006870327051728964,
0.049619026482105255,
-0.02760058455169201,
0.020587125793099403,
-0.020121946930885315,
-0.01115831732749939,
-0.0008535725064575672,
-0.020563270896673203,
-0.06440931558609009,
-0.055725984275341034,
0.006566172000020742,
-0.003927179146558046,
-0.007222192827612162,
0.006989603396505117,
-0.01312041562050581,
0.05009613558650017,
0.022280851379036903,
0.018249306827783585,
-0.011206028051674366,
-0.03680872917175293,
0.03148899972438812,
-0.020730257034301758,
0.056489355862140656,
0.014384747482836246,
0.037405114620923996,
-0.005865422543138266,
-0.029055757448077202,
0.011575785465538502,
0.007377251982688904,
-0.04091184213757515,
-0.029198888689279556,
0.007800683844834566,
-0.018988819792866707,
0.005608977749943733,
-0.041484370827674866,
0.020921099931001663,
-0.025405896827578545,
-0.01598305255174637,
-0.057157304137945175,
-0.03690415248274803,
0.011540002189576626,
-0.01051422394812107,
-0.0036647708620876074,
-0.041818343102931976,
0.029771417379379272,
-0.021374350413680077,
0.0020828661508858204,
-0.02365253120660782,
-0.021147724241018295,
0.032848749309778214,
0.002461568918079138,
0.012321263551712036,
-0.0408402755856514,
0.042462438344955444,
0.023592893034219742,
0.03816848248243332,
-0.04303496330976486,
0.045897599309682846,
0.01551787368953228,
-0.01482607051730156,
0.007359360810369253,
0.024976501241326332,
-0.05348358675837517,
0.021839529275894165,
-0.051718294620513916,
0.002498842775821686,
-0.0023601839784532785,
-0.004714404232800007,
-0.01211849320679903,
0.03470946475863457,
-0.028864914551377296,
-0.014635227620601654,
-0.0017980934353545308,
-0.01150421891361475,
-0.01752171851694584,
0.044156163930892944,
-0.02938973158597946,
0.060544755309820175,
-0.014444385655224323,
0.0016147057758644223,
-0.014587516896426678,
-0.02795841358602047,
-0.016865698620676994,
0.02798226848244667,
-0.0023840393405407667,
-0.020098092034459114,
0.040816422551870346,
-0.03649861365556717,
0.03196610510349274,
0.00787224993109703,
-0.02057519741356373,
-0.040053050965070724,
0.0187741219997406,
0.010567898862063885,
-0.003462000750005245,
-0.005987680982798338,
-0.016173895448446274,
0.01133723184466362,
-0.034280069172382355,
-0.006262016948312521,
0.05329274386167526,
-0.025692159309983253,
-0.03337356820702553,
0.029175033792853355,
-0.027195043861865997,
0.05295877158641815,
0.0007451054407283664,
-0.02559673972427845,
0.053006481379270554,
0.036665599793195724,
0.07280638068914413,
-0.038430891931056976,
0.042462438344955444,
-0.001408953801728785,
-0.046016875654459,
-0.013669087551534176,
0.010037118569016457,
0.01128355786204338,
0.013514028862118721,
-0.03275332972407341,
0.03761981055140495,
0.04534892737865448,
0.02218542993068695,
-0.0012188567779958248,
-0.003628987818956375,
0.02698034606873989,
-0.020145801827311516,
-0.02457096055150032,
-0.0016937264008447528,
0.013955351896584034,
0.022555187344551086,
0.03363597393035889,
0.014766432344913483,
-0.07328348606824875,
0.021994588896632195,
-0.030892616137862206,
-0.050000712275505066,
0.029580574482679367,
0.001951661892235279,
-0.04472869262099266,
0.08220537006855011,
-0.001400007982738316,
0.03208538144826889,
0.059208858758211136,
0.0031190807931125164,
0.0019322794396430254,
-0.004964884836226702,
-0.013692943379282951,
-0.02664637193083763,
0.03685644268989563,
-0.003628987818956375,
0.04289183393120766,
0.005600031930953264,
0.03544897958636284,
0.008045200258493423,
0.030606351792812347,
-0.0009460118017159402,
0.025787580758333206,
0.00708502484485507,
0.016734493896365166,
-0.03711884841322899,
-0.05329274386167526,
0.04570676013827324,
0.010848199017345905,
0.04871252551674843,
0.023282773792743683,
-0.021767962723970413,
0.005817711818963289,
-0.03676101937890053,
0.011039040982723236,
0.00100490462500602,
-0.0011398361530154943,
0.029914548620581627,
0.007794720120728016,
-0.02290108986198902,
-0.004228352103382349,
0.07729117572307587,
0.046255432069301605,
-0.027171188965439796,
-0.012213914655148983,
0.006566172000020742,
-0.04198533296585083,
0.012040963396430016,
-0.040792565792798996,
0.011677170172333717,
-0.04191376641392708,
0.027552872896194458,
-0.01418197713792324,
-0.04709036648273468,
0.04203304275870323,
0.009852239862084389,
0.047281209379434586,
-0.024403974413871765,
-0.031250447034835815,
-0.004556362517178059,
-0.0255490280687809,
0.004747204948216677,
-0.019609058275818825,
0.014623300172388554,
-0.06564979255199432,
0.010985367000102997,
0.03439934551715851,
-0.04468097910284996,
-0.0009012831142172217,
0.013287403620779514,
0.06393221020698547,
-0.016245460137724876,
0.021302783861756325,
-0.03272947296500206,
-0.015553656965494156,
0.05348358675837517,
0.037691377103328705,
-0.017891475930809975,
0.004893318749964237,
-0.02793455868959427,
0.020324716344475746,
-0.013001139275729656,
0.004031545948237181,
0.018583280965685844,
-0.004917174112051725,
-0.01501691248267889,
0.03742896765470505,
-0.029222745448350906,
0.02724275551736355,
0.006512497551739216,
0.00371248135343194,
0.009595795534551144,
-0.010275671258568764,
0.0058982232585549355,
0.05329274386167526,
0.05367442965507507,
-0.004788951948285103,
-0.008444776758551598,
0.004413230810314417,
0.0341607928276062,
-0.03408922627568245,
-0.003804920706897974,
0.013132344000041485,
-0.011367050930857658,
-0.004499706439673901,
-0.013191982172429562,
0.038001496344804764,
0.0213624220341444,
-0.04990529268980026,
0.012822224758565426,
0.01839243806898594,
0.057538989931344986,
0.004255189560353756,
0.020062308758497238,
0.03955208882689476,
0.08339813351631165,
-0.01795111410319805,
0.06545894593000412,
0.0024869153276085854,
0.00842688512057066,
-0.01564907841384411,
-0.006026445422321558,
0.0375959575176239,
0.00614870386198163,
-0.011384942568838596,
-0.03206152468919754,
-0.021636757999658585,
-0.020992666482925415,
-0.008432849310338497,
0.00031664184643886983,
0.0020083182025700808,
0.00044542321120388806,
0.008379174396395683,
0.01550594624131918,
0.020062308758497238,
-0.03654632344841957,
-0.03280103951692581,
0.007401107344776392,
-0.035973794758319855,
-0.0614035464823246,
0.020193513482809067,
-0.033993806689977646,
0.006178523413836956,
0.014289326034486294,
-0.0018368582241237164,
-0.021565193310379982,
-0.009792601689696312,
0.02418927662074566,
-0.0017429280560463667,
-0.030487075448036194,
0.00854019820690155,
-0.015541729517281055,
0.03206152468919754,
-0.006100993603467941,
0.01897689327597618,
0.03549668937921524,
-0.007931888103485107,
-0.026789503172039986,
0.034661754965782166,
-0.03167984262108803,
0.023020366206765175,
-0.022710246965289116,
0.02829238772392273,
0.019537491723895073,
0.006321655120700598,
-0.017915330827236176,
-0.02760058455169201,
-0.045515917241573334,
-0.01864291913807392,
-0.014873780310153961,
-0.015148116275668144,
-0.02439204603433609,
0.02495264634490013,
-0.020944954827427864,
-0.051670584827661514,
0.02865021675825119,
-0.003605132456868887,
0.012124457396566868,
-0.04947589710354805,
0.0170565415173769,
-0.05057324096560478,
0.002285636030137539,
0.026097699999809265,
-0.024833370000123978,
0.026169266551733017,
0.020885316655039787,
-0.03198995813727379,
0.006882254499942064,
0.0037572099827229977,
0.02421313151717186,
0.009446699172258377,
-0.02238820120692253,
-0.0030982072930783033,
0.01607847400009632,
-0.030844904482364655,
0.05252937600016594,
-0.02149362675845623,
-0.03790607303380966,
-0.008802606724202633,
-0.01605461910367012,
0.005695453379303217,
-0.010251816362142563,
0.022352417930960655,
0.027433596551418304,
-0.01592341437935829,
0.0018607135862112045,
0.025453606620430946,
-0.005719308741390705,
-0.04513423144817352,
0.02080182358622551,
-0.008122730068862438,
-0.03921811655163765,
0.007222192827612162,
-0.03482874110341072,
-0.02049170434474945,
-0.001893514534458518,
0.00562985148280859,
0.004562326706945896,
-0.0068405079655349255,
0.023091932758688927,
0.054008401930332184,
0.029055757448077202,
-0.027385886758565903,
-0.0030952254310250282,
0.018010752275586128,
0.009500374086201191,
-0.02356903813779354,
-0.022256996482610703,
-0.003819830249994993,
-0.03683258593082428,
-0.043106529861688614,
-0.0011457999935373664,
-0.004636874422430992,
0.0011323813814669847,
0.0009445208706893027,
-0.038430891931056976,
0.005057324189692736,
-0.01790340431034565,
-0.004022600129246712,
0.013955351896584034,
-0.021255074068903923,
-0.004240280017256737,
-0.022149648517370224,
0.012858008034527302,
-0.012858008034527302,
-0.00026073100161738694,
0.026169266551733017,
0.009536157362163067,
-0.024642527103424072,
0.012714875862002373,
0.004177659749984741,
0.011343196034431458,
-0.01486185286194086,
-0.016531724482774734,
0.009595795534551144,
0.013561739586293697,
-0.00630376348271966,
0.03375525400042534,
0.02488107979297638,
-0.006882254499942064,
-0.009243929758667946,
-0.010901872999966145,
0.018762195482850075,
0.004386393819004297,
0.0015491036465391517,
-0.01770063489675522,
0.010221997275948524,
-0.007723154034465551,
0.05772982910275459,
0.04678024724125862,
-0.0239030122756958,
-0.0010190686443820596,
-0.0010369601659476757,
-0.01536281406879425,
-0.0145040238276124,
-0.0018517677672207355,
0.030510930344462395,
-0.001902460353448987,
0.00387946842238307,
-0.027028057724237442,
0.03864558786153793,
0.02434433624148369,
0.00331886881031096,
-0.009560012258589268,
0.004997685551643372,
0.02095688320696354,
0.03697571903467178,
-0.007663515862077475,
-0.02588300220668316,
0.004535489249974489,
-0.013191982172429562,
0.01718774437904358,
-0.019513636827468872,
-0.0425817146897316,
-0.0027865974698215723,
-0.004296936094760895,
-0.0006698121433146298,
0.014802214689552784,
0.003524620784446597,
-0.00969718024134636,
0.006518461275845766,
0.005480755586177111,
-0.028507085517048836,
-0.0028372900560498238,
0.008742968551814556,
0.03342127799987793,
0.015446308068931103,
-0.01484992541372776,
-0.0014842470409348607,
-0.015243537724018097,
0.026861069723963737,
0.0021812692284584045,
0.03103574737906456,
-0.029079612344503403,
0.016984974965453148,
-0.034280069172382355,
0.010532115586102009,
-0.032276224344968796,
-0.002072429284453392,
0.028793349862098694,
0.013979206793010235,
-0.02528662048280239,
-0.004469887353479862,
-0.007174482103437185,
-0.0012792405905202031,
0.003435163525864482,
-0.005868404172360897,
0.03943281248211861,
0.0375005342066288,
0.02434433624148369,
-0.01589955948293209,
-0.002661357168108225,
-0.026479385793209076,
-0.011098679155111313,
0.029509007930755615,
0.0323716439306736,
-0.02931816689670086,
0.0409834086894989,
-0.03490030765533447,
0.008689293637871742,
-0.009470555000007153,
-0.013502100482583046,
-0.019632913172245026,
0.0034649826120585203,
-0.030105391517281532,
-0.009870131500065327,
-0.021994588896632195,
-0.022328563034534454,
-0.004896300844848156,
-0.0016206696163862944,
0.014885708689689636,
-0.024380117654800415,
-0.017307020723819733,
0.010216033086180687,
0.013740654103457928,
0.014086555689573288,
0.012726803310215473,
0.008218151517212391,
0.00802730955183506,
-0.05023926496505737,
0.010520188137888908,
0.008432849310338497,
0.001801075297407806,
-0.00987609475851059,
-0.005140817724168301,
-0.00614274013787508,
-0.003542512422427535,
0.007514419965445995,
-0.0038615770172327757,
0.0024317498318850994,
-0.01486185286194086,
0.012148312292993069,
-0.006643701810389757,
0.02731432020664215,
0.012691020965576172,
0.0037751016207039356,
-0.009476518258452415,
0.005096089094877243,
-0.013991134241223335,
0.005361479241400957,
-0.0019158789655193686,
-0.028793349862098694,
-0.019704479724168777,
-0.022972656413912773,
-0.02490493468940258,
0.01846400462090969,
0.002211088314652443,
0.013096560724079609,
-0.01826123334467411,
0.016460157930850983,
-0.014432457275688648,
-0.0027239772025495768,
-0.01792725920677185,
0.022149648517370224,
-0.016806060448288918,
0.0060413554310798645,
-0.010072900913655758,
0.008456704206764698,
0.004478832706809044,
-0.03509115055203438,
-0.03482874110341072,
0.03886028751730919,
-0.03272947296500206,
0.03824004903435707,
-0.028196966275572777,
0.016794132068753242,
0.03377910703420639,
-0.08988677710294724,
-0.04091184213757515,
0.028220823034644127,
-0.006536352913826704,
0.0014589008642360568,
0.002867109142243862,
-0.020837606862187386,
-0.005450936499983072,
0.0443231500685215,
-0.029079612344503403,
0.011384942568838596,
0.005570212844759226,
0.02367638796567917,
-0.01016832236200571,
0.0016370700905099511,
-0.012989211827516556,
-0.018678700551390648,
-0.048951078206300735,
-0.01178451906889677,
0.02356903813779354,
0.003992781043052673,
-0.01739051565527916,
-0.010997294448316097,
0.01759328506886959,
-0.010341273620724678,
0.019203517585992813,
-0.011152354069054127,
-0.021791817620396614,
-0.048259276896715164,
-0.0026225922629237175,
-0.00692400150001049,
0.008391102775931358,
-0.02024122327566147,
0.03342127799987793,
-0.03468560799956322,
-0.03105960227549076,
0.039766788482666016,
-0.027004200965166092,
-0.02080182358622551,
0.009774710051715374,
0.04842626303434372,
0.007693334948271513,
0.019525565207004547,
0.01723545603454113,
-0.03680872917175293,
-0.02972370572388172,
-0.027910703793168068,
-0.0011077806120738387,
0.0008886100258678198,
0.005057324189692736,
0.027195043861865997,
-0.004478832706809044,
-0.013764508999884129,
0.020277006551623344,
-0.011229882948100567,
0.0007820065948180854,
0.00012551988766063005,
0.05710959434509277,
0.04344050586223602,
-0.012201987206935883,
-0.02962828427553177,
0.04396532103419304,
0.03695186227560043,
0.001313532586209476,
-0.004872445482760668,
-0.023330485448241234,
-0.03177526220679283,
0.032228514552116394,
-0.018845688551664352,
0.00775893684476614,
-0.03795378655195236,
0.030892616137862206,
-0.03373139724135399,
0.028578652068972588,
-0.028554797172546387,
0.012476323172450066,
-0.019251229241490364,
-0.00997748039662838,
0.007401107344776392,
0.004022600129246712,
-0.012667165137827396,
-0.006244125310331583,
-0.03616463765501976,
0.009935732930898666,
-0.018988819792866707,
-0.008975557051599026,
-0.01516004465520382,
0.03845474496483803,
0.0004446777456905693,
-0.00837321113795042,
-0.011569821275770664,
0.0036617887672036886,
-0.002202142495661974,
-0.0005930279148742557,
-0.010233924724161625,
-0.01654365099966526,
-0.032419353723526,
0.017939187586307526,
0.034280069172382355,
-0.031918395310640335,
0.044537849724292755,
-0.03213309124112129,
0.01752171851694584,
-0.044800255447626114,
-0.03821619227528572,
-0.006423039827495813,
0.005534430034458637,
-0.01277451403439045,
0.014050772413611412,
-0.000977321877144277,
0.0357113853096962,
-0.01603076234459877,
0.03776294365525246,
-0.025382041931152344,
-0.016865698620676994,
0.0038705228362232447,
0.022746030241250992,
-0.021791817620396614,
-0.005218347068876028,
-0.01142669003456831,
0.045563627034425735,
0.013168126344680786,
-0.0040911841206252575,
0.014241615310311317,
-0.009649469517171383,
0.025071922689676285,
0.004440068267285824,
0.020360499620437622,
-0.008504414930939674,
0.0008438812801614404,
0.0035991687327623367,
0.005054342094808817,
0.029866838827729225,
0.007842430844902992,
-0.015231610275804996,
0.04398917779326439,
0.040076907724142075,
0.025405896827578545,
0.01468293834477663,
0.02401036210358143,
0.005883313715457916,
0.0041746776551008224,
0.01959712989628315,
-0.01260752696543932,
0.016281243413686752,
0.0005005886196158826,
-0.04305882006883621,
0.0064468951895833015,
0.011074824258685112,
0.01434896420687437,
-0.029890693724155426,
0.01754557527601719,
0.048903368413448334,
0.04203304275870323,
0.004768078681081533,
0.02057519741356373,
0.008641582913696766,
-0.04563519358634949,
-0.01941821537911892,
0.012476323172450066,
-0.046517837792634964,
0.05295877158641815,
-0.03790607303380966,
0.010931692086160183,
0.038741011172533035,
-0.0003691980673465878,
-0.015708716586232185,
-0.004240280017256737,
0.027910703793168068,
0.027218898758292198,
-0.013633305206894875,
-0.07252011448144913,
0.010436694137752056,
-0.005811748094856739,
-0.017760273069143295,
0.02180374599993229,
0.026121554896235466,
0.008349355310201645,
0.02120736427605152,
0.031202735379338264,
-0.04990529268980026,
-0.016042690724134445,
0.01879797875881195,
0.009011340327560902,
0.035615965723991394,
-0.015780283138155937,
-0.011647351086139679,
-0.037405114620923996,
-0.007395143620669842,
-0.008116766810417175,
-0.04389375448226929,
-0.020813750103116035,
0.021374350413680077,
0.03179911896586418,
0.01607847400009632,
-0.021398205310106277,
-0.014289326034486294,
-0.006584063172340393,
-0.038359325379133224,
-0.02588300220668316,
-0.05396069213747978,
0.027552872896194458,
0.03482874110341072,
0.0029088559094816446,
-0.03451862186193466,
0.014873780310153961,
0.01165927853435278,
-0.016436303034424782,
0.018786050379276276,
0.02372409775853157,
0.005537412129342556,
0.05739585682749748,
-0.00418064184486866,
0.035592108964920044,
0.024499395862221718,
0.014730649068951607,
0.02205422706902027,
-0.01585184782743454,
-0.01468293834477663,
-0.024093855172395706,
-0.04200918599963188,
-0.05157516151666641,
-0.001933770370669663,
-0.02459481544792652,
-0.00887417234480381,
-0.013144271448254585,
0.02659866213798523,
0.0038228121120482683,
-0.010096756741404533,
0.019537491723895073,
-0.010269707068800926,
0.0059817167930305,
0.02203037217259407,
-0.0004938793135806918,
0.008289717137813568,
-0.010615609586238861,
-0.016603291034698486,
-0.021577119827270508,
0.0255490280687809,
0.017986897379159927,
0.04408459737896919,
0.021815674379467964,
0.0010324872564524412,
-0.02698034606873989,
-0.032252367585897446,
0.016531724482774734,
0.04105497524142265,
-0.04835469648241997,
0.01310848817229271,
-0.007776828482747078,
-0.01149229146540165,
0.016531724482774734,
0.03556825593113899,
0.010639464482665062,
0.05605996027588844,
0.007317613810300827,
0.0035723315086215734,
0.03816848248243332,
0.027147334069013596,
0.005337623879313469,
0.006870327051728964,
0.010949583724141121,
0.010889945551753044,
-0.022996511310338974,
-0.00331886881031096,
-0.007228156551718712,
-0.011987289413809776,
0.0024705147370696068,
-0.004135912749916315,
0.02051555924117565,
0.0022886181250214577,
0.026861069723963737,
0.00775297312065959,
0.01536281406879425,
0.015243537724018097,
0.010257779620587826,
0.013144271448254585,
0.009744890965521336,
-0.019835684448480606,
-0.006661592982709408,
-0.011289522051811218,
-0.008498451672494411,
0.0009557030280120671,
0.011969397775828838,
0.015267393551766872,
-0.011778554879128933,
-0.01587570272386074,
0.014551734551787376,
0.0255728829652071,
-0.013132344000041485,
-0.04501495510339737,
-0.018702557310461998,
-0.006160631775856018,
-0.024105781689286232,
-0.03005767986178398,
-0.026336252689361572,
0.02831624262034893,
0.0071625541895627975,
0.014444385655224323,
-0.04100726544857025,
0.0022215249482542276,
0.007067133206874132,
-0.006035391241312027,
-0.013323185965418816,
0.04814000055193901,
-0.026336252689361572,
-0.013907641172409058,
-0.042796410620212555,
0.033254291862249374,
-0.02865021675825119,
-0.032920315861701965,
-0.003554440103471279,
0.016448231413960457,
0.012977284379303455,
0.022555187344551086,
0.010275671258568764,
-0.0222331415861845,
0.016090400516986847,
0.009243929758667946,
0.015935340896248817,
-0.011778554879128933,
0.0325147770345211,
0.024403974413871765,
-0.03208538144826889,
-0.025405896827578545,
-0.013036922551691532,
0.004443049896508455,
-0.02624083124101162,
0.0018771140603348613,
-0.009142544120550156,
0.021076159551739693,
0.0032801039051264524,
0.0074726734310388565,
0.002901401137933135,
0.0010690157068893313,
0.007347432896494865,
-0.01050229649990797,
-0.012207950465381145,
0.015553656965494156,
0.013537883758544922,
0.007478637155145407,
-0.0003397516848053783,
-0.005528466310352087,
-0.0005289167747832835,
0.023592893034219742,
-0.018738340586423874,
-0.012977284379303455,
-0.020634835585951805,
-0.017831837758421898,
-0.01959712989628315,
0.050620950758457184,
-0.0060324096120893955,
-0.0427248440682888,
0.026097699999809265,
0.02965214103460312,
-0.0093751335516572,
-0.01649594120681286,
0.028173111379146576,
-0.021565193310379982,
-0.013239692896604538,
-0.0054479544050991535,
0.036283913999795914,
0.021064231172204018,
-0.004717385862022638,
-0.0070313503965735435,
0.005916114896535873,
-0.014253542758524418,
0.01227355282753706,
-0.015303175896406174,
0.0026807396207004786,
-0.003426217706874013,
-0.024976501241326332,
0.002461568918079138,
-0.013156198896467686,
0.013370896689593792,
0.022221213206648827,
0.05085950344800949,
0.012869935482740402,
-0.008331464603543282,
0.03005767986178398,
0.013502100482583046,
-0.005152745172381401,
0.014730649068951607,
-0.02729046531021595,
-0.026097699999809265,
-0.020551342517137527,
-0.021314712241292,
-0.01574449986219406,
-0.0066138822585344315,
-0.03351669758558273,
-0.010114648379385471,
-0.02626468800008297,
-0.009798564948141575,
-0.0011219446314498782,
-0.03554439917206764,
-0.0027865974698215723,
0.0024466593749821186,
0.0027493236120790243,
-0.006912073586136103,
-0.016507869586348534,
-0.04751976206898689,
-0.011188136413693428,
0.02698034606873989,
0.00613081268966198,
0.015768354758620262,
0.005561267491430044,
0.021577119827270508,
0.011313376948237419,
-0.006050300784409046,
0.024666381999850273,
-0.04365520179271698,
-0.01659136265516281,
-0.03509115055203438,
0.04303496330976486,
-0.032419353723526,
-0.0044579594396054745,
0.0028879824094474316,
-0.024499395862221718,
-0.030773339793086052,
-0.01821352355182171,
-0.0022095972672104836,
0.0009027741034515202,
0.0010160867823287845,
0.01906038634479046,
-0.006816652603447437,
0.007794720120728016,
0.020813750103116035,
0.01047844160348177,
-0.05367442965507507,
-0.0008200259762816131,
0.0051736184395849705,
0.007514419965445995,
0.004001726862043142,
-0.026073845103383064,
-0.025477463379502296,
0.026670226827263832,
0.011683134362101555,
0.015374742448329926,
-0.019883394241333008,
-0.028149256482720375,
0.012822224758565426,
-0.018452076241374016,
0.02521505393087864,
0.03480488434433937,
0.010573862120509148,
-0.03893185406923294,
0.001467846566811204,
-0.009232002310454845,
0.017462080344557762,
0.017557501792907715,
0.02282952331006527,
-0.005653706379234791,
-0.0030057679396122694,
-0.01926315575838089,
-0.02169639803469181,
-0.002589791314676404,
-0.011575785465538502,
0.007365324534475803,
0.00997748039662838,
0.01569678820669651,
-0.03385067358613014,
-0.002531643956899643,
-0.0016758349956944585,
0.03280103951692581,
0.01016832236200571,
-0.006440931465476751,
-0.018332799896597862,
-0.01882183365523815,
-0.016806060448288918,
-0.023819519206881523,
0.004768078681081533,
0.01913195289671421,
0.011766627430915833,
0.004416212905198336,
0.021863384172320366,
-0.021326640620827675,
0.027099622413516045,
-0.005868404172360897,
0.012488250620663166,
0.0043088640086352825,
-0.029938403517007828,
0.017151962965726852,
0.014802214689552784,
-0.009226038120687008,
-0.01519582699984312,
0.010579826310276985,
0.019203517585992813,
-0.010943619534373283,
0.012512105517089367,
0.010866089724004269,
0.005552321672439575,
-0.010913800448179245,
-0.018320871517062187,
-0.016293171793222427,
0.013144271448254585,
0.011277593672275543,
-0.010275671258568764,
-0.009291640482842922,
-0.01132530439645052,
0.004362538456916809,
0.008450740948319435,
0.01649594120681286,
0.022579044103622437,
0.004535489249974489,
-0.002315455349162221,
-0.008403030224144459,
-0.044180020689964294,
-0.056441646069288254,
0.00948844663798809,
-0.01077066920697689,
-0.020062308758497238,
0.01211849320679903,
-0.010275671258568764,
0.03277718648314476,
0.027862992137670517,
-0.04026775062084198,
-0.0064468951895833015,
0.023604821413755417,
0.016126183792948723,
0.01759328506886959,
0.008176404982805252,
0.0008162985905073583,
0.02659866213798523,
0.0045831999741494656,
-0.01585184782743454,
-0.011056932620704174,
0.00983434822410345,
0.010037118569016457,
-0.03418464586138725,
-0.01567293331027031,
0.04060172289609909,
-0.010949583724141121,
0.014623300172388554,
-0.022197358310222626,
-0.016293171793222427,
0.03957594558596611,
-0.0289841927587986,
-0.021255074068903923,
-0.004156786482781172,
-0.01572064310312271,
-0.0341607928276062,
-0.0093751335516572,
0.005576177034527063,
0.004055401310324669,
-0.024225059896707535,
0.021255074068903923,
0.03540126979351044,
-0.01854749768972397,
-0.032896462827920914,
0.0005229529342614114,
0.029771417379379272,
-0.00709098856896162,
-0.0070969522930681705,
-0.008522306568920612,
-0.009416880086064339,
-0.03645090013742447,
-0.0029893675819039345,
-0.0170803964138031,
-0.0026956491637974977,
-0.00725797563791275,
0.023867228999733925,
0.00482175312936306,
0.027839137241244316,
-0.0019531529396772385,
0.01734280399978161,
0.000016936332031036727,
-0.028769494965672493,
-0.017199672758579254,
-0.0061904508620500565,
-0.00452057970687747,
-0.0009706125711090863,
-0.014158121310174465,
-0.008456704206764698,
0.012052890844643116,
-0.002782124560326338,
0.04136509448289871,
-0.012249697931110859,
-0.01767677813768387,
-0.00031198261422105134,
0.012136384844779968,
-0.0035723315086215734,
0.028220823034644127,
-0.017318949103355408,
0.008766823448240757,
-0.014527878724038601,
-0.00920814648270607,
-0.02077796868979931,
0.02182760089635849,
-0.02372409775853157,
0.009202182292938232,
-0.05591682717204094,
0.0027642331551760435,
0.027218898758292198,
-0.01132530439645052,
-0.014599444344639778,
0.051050346344709396,
-0.003059442387893796,
0.010883981361985207,
-0.01692533679306507,
-0.019275084137916565,
0.0010324872564524412,
0.02936587668955326,
-0.011677170172333717,
-0.02962828427553177,
-0.012869935482740402,
-0.018857616931200027,
0.006077138241380453,
-0.025787580758333206,
-0.007341469172388315,
0.011706989258527756,
-0.024833370000123978,
-0.00014825697871856391,
0.009172363206744194,
-0.009172363206744194,
0.006506533827632666,
0.01499305758625269,
-0.05071637034416199,
-0.0007044769008643925,
-0.021589048206806183,
0.03418464586138725,
0.018249306827783585,
0.03752439096570015,
-0.0238791573792696,
-0.00082971720257774,
0.029532864689826965,
0.02731432020664215,
-0.0019755172543227673,
0.007001531310379505,
0.03525813668966293,
-0.0063156913965940475,
-0.005134853534400463,
0.0170803964138031,
0.025143487378954887,
-0.024153493344783783,
0.005179582629352808,
-0.00869525782763958,
-0.004768078681081533,
0.02356903813779354,
-0.017831837758421898,
0.0050245230086147785,
-0.0039987447671592236,
0.017843766137957573,
0.005984698887914419,
0.005075215362012386,
-0.030868761241436005,
0.01467101089656353,
0.009965552017092705,
-0.003339742310345173,
0.0030952254310250282,
-0.0009102288750000298,
-0.028411664068698883,
0.005605996120721102,
0.003083297749981284,
0.027433596551418304,
0.011814338155090809,
0.007824539206922054,
0.007729117758572102,
0.0026196104008704424,
-0.027409741654992104,
-0.02269832044839859,
0.015887631103396416,
0.0028700910042971373,
-0.013871857896447182,
0.014575589448213577,
0.002895437180995941,
0.0053406055085361,
0.03339742124080658,
0.033254291862249374,
-0.0324670672416687,
-0.005480755586177111,
-0.030558641999959946,
-0.01569678820669651,
-0.00741899898275733,
0.003259230637922883,
0.15296019613742828,
-0.018344726413488388,
-0.024499395862221718,
-0.007949779741466045,
-0.017652923241257668,
-0.010227960534393787,
-0.003986817318946123,
-0.01467101089656353,
0.010466514155268669,
-0.004976812284439802,
0.02896033599972725,
0.004273080732673407,
0.02967599593102932,
0.03265791013836861,
0.00841495767235756,
-0.005513556767255068,
0.019716406241059303,
0.037357401102781296,
-0.004565308336168528,
0.001810020999982953,
-0.0015655042370781302,
0.0027925611939281225,
-0.028244677931070328,
0.036713309586048126,
-0.044156163930892944,
-0.0016415430000051856,
-0.008999412879347801,
-0.042462438344955444,
0.01672256737947464,
-0.010299526154994965,
-0.005838585086166859,
0.0025629540905356407,
0.0034560367930680513,
-0.007782792206853628,
-0.004150822758674622,
-0.0460645891726017,
0.003965944051742554,
-0.013191982172429562,
-0.011015186086297035,
0.03342127799987793,
0.005045396275818348,
0.028149256482720375,
0.017271239310503006,
0.009548084810376167,
0.04227159544825554,
0.02490493468940258,
-0.021994588896632195,
0.022256996482610703,
0.021302783861756325,
-0.008725076913833618,
0.0036319696810096502,
-0.0009624123340472579,
0.024475539103150368,
-0.015684861689805984,
-0.007061169482767582,
-0.0038108844310045242,
0.006685448344796896,
-0.0032950136810541153,
-0.008146585896611214,
-0.022149648517370224,
-0.014742576517164707,
0.02082567848265171,
0.0021931969095021486,
-0.008456704206764698,
0.014396674931049347
] | 2024-07-21 | 1 | 39032532 | [
"T cells",
"CAR)-engineered T cells",
"different anti-tumor effects",
"anti-tumor efficacy",
"different CSDs",
"CAR",
"CAR-T cells",
"Various CSDs",
"CSDs",
"the anti-tumor efficacy",
"the anti-hematological effects",
"CAR-T function",
"Chimeric antigen receptor",
"a co-stimulatory domain",
"potential guidance",
"further interventions",
"medicinal applications",
"CAR-T",
"the CAR structure",
"Previous studies",
"the underlying molecular mechanisms",
"pathways",
"the molecular mechanism",
"the possible mechanism",
"CSD",
"a unique role",
"the limited references",
"immunotherapy",
"the specific characteristics",
"the effects"
] | [
"Anti-tumor efficacy",
"CAR-T",
"CSD",
"IgSF",
"Molecular mechanism",
"TNFRSF"
] | 0 | 10.1016/j.bcp.2024.116439 | [
"Zhao",
"Yao",
"Li",
"Xue",
"Gao",
"Liu",
"Zhang",
"Zheng",
"Sun"
] | [
"Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.",
"Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.",
"Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.",
"Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.",
"Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.",
"Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.",
"Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China. Electronic address: [email protected].",
"Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China. Electronic address: [email protected].",
"Cancer Institute, the First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China. Electronic address: [email protected]."
] | [
"39032532"
] | [] | 8.416869 | 4.553822 |
39032527 | 709 | Development of TaqMan-based real-time PCR based on ψ gene for quantitative detection of CAR-T cells. | Chimeric-antigen-receptor-T (CAR-T) have heralded a paradigm shift in the landscape of cancer immunotherapy. Retrovirus-mediated gene transfer serves to deliver the specific CAR expressing cassette into T cells across a spectrum of basic research and clinical contests in cancer therapy. However, it is necessary to devise a precise and validated quantitative methodology tailored to the diverse CAR constructs. In the investigation, a TaqMan real-time qPCR method was developed, utilizing primers targeting ψ gene sequence. This method offers a swift, sensitive, reproducible, and accurate tool for evaluating retroviral copy numbers at the integrated DNA level. Importantly, the established qPCR exhibits no cross-reactivity with non-transduced T cells or tissues. The regression equation characterizing TaqMan real-time PCR dynamics is y = -3.3841x + 41.402 (R | [
0.010356099344789982,
-0.0100855128839612,
0.026271529495716095,
0.03333139047026634,
-0.06361252814531326,
-0.011961172334849834,
-0.012078016065061092,
0.016481203958392143,
-0.007914667949080467,
-0.032347436994314194,
0.008671080693602562,
-0.012631489895284176,
-0.01725606620311737,
-0.0040649534203112125,
0.00017219167784787714,
-0.04012066125869751,
-0.0056546516716480255,
-0.007773224264383316,
-0.007705577649176121,
0.030551724135875702,
0.026615913957357407,
-0.002399921417236328,
-0.035397689789533615,
-0.019211672246456146,
0.02233572117984295,
-0.0170469768345356,
0.016013825312256813,
0.02617313526570797,
-0.02425442822277546,
-0.02644372172653675,
0.001394445076584816,
-0.03276561573147774,
-0.022102031856775284,
-0.03099450282752514,
-0.024734104052186012,
0.03200305253267288,
0.009599685668945312,
-0.025730356574058533,
-0.029297184199094772,
-0.022815397009253502,
0.02354106307029724,
0.024082235991954803,
0.015325059182941914,
0.0709429681301117,
-0.02777205780148506,
-0.0008817136404104531,
-0.034610528498888016,
-0.05087034031748772,
0.0076932781375944614,
0.02069989964365959,
-0.04560619592666626,
-0.022557109594345093,
-0.05347781628370285,
0.04267893731594086,
-0.044917430728673935,
0.021597756072878838,
-0.025004692375659943,
0.038201954215765,
0.005845292471349239,
0.038374144583940506,
0.034143149852752686,
-0.011352350935339928,
0.016173718497157097,
-0.030822310596704483,
-0.06607240438461304,
0.016739491373300552,
-0.04381048306822777,
0.017219167202711105,
0.0076010324992239475,
0.022766198962926865,
0.025213781744241714,
0.03180626407265663,
0.017292963340878487,
-0.012643788941204548,
0.026123937219381332,
0.009095410816371441,
-0.03601266071200371,
0.047500304877758026,
-0.020908989012241364,
0.003376186825335026,
0.0524938628077507,
-0.015140567906200886,
0.02703409269452095,
-0.04063723608851433,
-0.025607362389564514,
-0.024746404960751534,
0.032962407916784286,
-0.027919650077819824,
-0.005574705544859171,
-0.009341398254036903,
-0.02927258610725403,
0.046491753309965134,
-0.016911683604121208,
0.04481903463602066,
0.020589204505085945,
-0.006195825524628162,
-0.02458651177585125,
-0.033749569207429886,
0.025361374020576477,
0.004633801057934761,
0.05854517221450806,
-0.006389541085809469,
0.00588526576757431,
0.002138559240847826,
0.02359025925397873,
0.015940029174089432,
-0.0689258724451065,
0.008271350525319576,
-0.006838469300419092,
-0.02360256016254425,
0.09549258649349213,
-0.014759286306798458,
-0.00895396713167429,
0.054904546588659286,
-0.001861822558566928,
-0.019285468384623528,
-0.04302332177758217,
-0.028534621000289917,
-0.031092897057533264,
0.027919650077819824,
-0.044327057898044586,
0.0032132198102772236,
0.06061147153377533,
-0.031363483518362045,
-0.0002473333734087646,
-0.010589788667857647,
0.033405184745788574,
-0.03908751159906387,
-0.029395578429102898,
-0.01083577610552311,
0.018129324540495872,
-0.009722679853439331,
0.035865068435668945,
0.02287689410150051,
-0.02049081027507782,
-0.03153567761182785,
0.006371092051267624,
0.00281810131855309,
-0.044720638543367386,
0.003834339790046215,
0.01950685679912567,
-0.02248331345617771,
-0.0556425116956234,
-0.011635237373411655,
-0.016444304957985878,
-0.057807207107543945,
-0.0427035354077816,
0.024426618590950966,
0.03087150864303112,
0.05387139692902565,
0.0013221860863268375,
0.03362657502293587,
0.017133072018623352,
0.009894872084259987,
0.0003051790117751807,
-0.024143733084201813,
-0.014525597915053368,
0.011094063520431519,
-0.03950569033622742,
-0.03247043117880821,
-0.011204758659005165,
-0.007133655250072479,
-0.041203007102012634,
-0.03940729424357414,
-0.0028980474453419447,
-0.021204175427556038,
0.01778494007885456,
0.008179104886949062,
-0.0767974853515625,
0.00593446334823966,
-0.03446293622255325,
-0.04228535667061806,
-0.05101793259382248,
-0.032691821455955505,
-0.04582758620381355,
0.02352876216173172,
0.008591135032474995,
0.025287577882409096,
-0.02292609214782715,
-0.016026126220822334,
0.0028119515627622604,
0.007810122333467007,
0.04388427734375,
0.0003933887928724289,
0.010509842075407505,
0.0026843452360481024,
-0.03726720064878464,
0.023836247622966766,
-0.0023245876654982567,
-0.029961351305246353,
0.030625520274043083,
0.04614736884832382,
0.06508845090866089,
0.025927146896719933,
0.02954317256808281,
-0.03660302981734276,
0.06159542500972748,
0.03224904090166092,
-0.036922816187143326,
-0.05888955295085907,
-0.027255482971668243,
-0.03525009751319885,
-0.03271641954779625,
-0.018141623586416245,
-0.02133946865797043,
-0.049271419644355774,
0.03429074212908745,
0.026123937219381332,
-0.05116552859544754,
-0.01678868941962719,
0.04371208697557449,
-0.0026751207187771797,
-0.02973996289074421,
0.018289215862751007,
-0.028657615184783936,
0.010884974151849747,
0.0017987880855798721,
0.06021789088845253,
0.022397218272089958,
0.02458651177585125,
-0.0540681853890419,
-0.0174405574798584,
-0.01533735916018486,
-0.01443950179964304,
-0.030846908688545227,
0.012219459749758244,
0.032618023455142975,
-0.045901380479335785,
0.03170786798000336,
-0.03635704144835472,
-0.008326697163283825,
0.04964040219783783,
0.0107742790132761,
-0.007213601376861334,
-0.012551543302834034,
0.012176411226391792,
0.015509550459682941,
-0.01810472458600998,
0.0065002357587218285,
-0.02777205780148506,
-0.03628324717283249,
0.03438913822174072,
0.02914959192276001,
-0.019592953845858574,
-0.02868221327662468,
-0.011586040258407593,
-0.01849830523133278,
-0.06764673441648483,
0.015361957252025604,
-0.013517046347260475,
0.00919380597770214,
0.005024307407438755,
0.0025106160901486874,
0.002845774870365858,
0.03047792613506317,
0.03564367815852165,
-0.0017649646615609527,
-0.0213517677038908,
0.019199371337890625,
-0.014796185307204723,
0.012379352003335953,
-0.005946762394160032,
-0.03985007479786873,
-0.007035260088741779,
-0.03247043117880821,
0.017477454617619514,
-0.013160363771021366,
0.024943195283412933,
-0.012975872494280338,
0.010725081898272038,
0.04540940374135971,
-0.020724497735500336,
0.04435165598988533,
-0.00555010698735714,
-0.07000821828842163,
0.022557109594345093,
0.014168915338814259,
0.03264262154698372,
0.01182587817311287,
0.031166693195700645,
-0.02605014108121395,
0.029247986152768135,
0.01745285652577877,
0.024229828268289566,
0.006740074139088392,
-0.025607362389564514,
0.05638047680258751,
0.005817618686705828,
0.027132488787174225,
-0.03682442009449005,
-0.001083116396330297,
0.006703176070004702,
-0.014021322131156921,
-0.02855921909213066,
-0.010122410953044891,
0.022581709548830986,
0.0027627539820969105,
-0.04627036303281784,
-0.04275273531675339,
-0.00459690298885107,
-0.02379935048520565,
-0.013467849232256413,
0.0068938168697059155,
-0.02715708687901497,
-0.014992975629866123,
0.020453911274671555,
-0.00835744570940733,
-0.03793136775493622,
-0.01790793426334858,
0.03323299437761307,
-0.0006614773883484304,
0.031363483518362045,
-0.0034253844060003757,
-0.02425442822277546,
0.027132488787174225,
0.029321782290935516,
0.015275862067937851,
-0.04924682155251503,
0.04218696057796478,
-0.07074618339538574,
-0.0458521842956543,
-0.0036590732634067535,
0.002310750773176551,
-0.0035914264153689146,
-0.0309453047811985,
-0.03468432277441025,
-0.014845382422208786,
-0.03807896003127098,
0.062038201838731766,
0.00042740433127619326,
0.029838357120752335,
-0.009236853569746017,
0.05160830542445183,
0.01410741824656725,
0.01371383760124445,
0.005543956998735666,
-0.029321782290935516,
-0.02828863263130188,
0.02153625898063183,
0.02696029655635357,
0.001349091064184904,
0.03131428733468056,
-0.01680098846554756,
0.056282080709934235,
0.017932534217834473,
0.011020267382264137,
0.012576142325997353,
0.0060543823055922985,
0.03593886271119118,
0.007773224264383316,
-0.014525597915053368,
0.01796943135559559,
0.036381643265485764,
-0.011383099481463432,
0.045901380479335785,
0.03576667234301567,
-0.0031517227180302143,
0.014513298869132996,
0.0048490408807992935,
-0.01410741824656725,
0.03180626407265663,
0.033355988562107086,
-0.04752490296959877,
0.02379935048520565,
0.05613448843359947,
0.035988058894872665,
-0.02114267833530903,
0.021068882197141647,
-0.046368759125471115,
-0.021843744441866875,
-0.03303620219230652,
-0.029321782290935516,
-0.01414431631565094,
-0.008123757317662239,
-0.018461408093571663,
-0.018621299415826797,
0.02558276429772377,
0.0370212122797966,
0.019592953845858574,
-0.00016998163482639939,
0.03906291350722313,
-0.015976928174495697,
-0.039677880704402924,
-0.01955605484545231,
0.009101560339331627,
0.02055230736732483,
0.02009722962975502,
0.0025690384209156036,
-0.05756121873855591,
0.026812704280018806,
-0.028510022908449173,
-0.029395578429102898,
0.017145371064543724,
-0.0462457649409771,
0.00014547890168614686,
0.059775110334157944,
0.014255011454224586,
0.07143494486808777,
0.03128968924283981,
0.02247101441025734,
0.011419998481869698,
0.002137021627277136,
-0.04587678238749504,
-0.022175827994942665,
-0.016948580741882324,
-0.015288161113858223,
0.020453911274671555,
0.03591426461935043,
0.02373785339295864,
0.01020850706845522,
0.017354460433125496,
0.023688655346632004,
0.01897798292338848,
0.05421578139066696,
0.01388602890074253,
-0.022852296009659767,
-0.011592189781367779,
0.05716763809323311,
0.000018809441826306283,
0.012047267518937588,
-0.0076379310339689255,
-0.04818907007575035,
-0.0001431727723684162,
-0.003207070054486394,
-0.020453911274671555,
-0.010946471244096756,
0.023479565978050232,
0.020343216136097908,
0.0060974303632974625,
-0.034192346036434174,
-0.0018525979248806834,
0.007933116517961025,
-0.01193042378872633,
-0.03357737883925438,
0.010128560476005077,
0.04526181146502495,
0.0007245118613354862,
-0.006912265904247761,
-0.0176373478025198,
0.06612160801887512,
-0.024500416591763496,
0.04361369088292122,
0.0024398944806307554,
-0.005058130715042353,
0.025213781744241714,
-0.014660891145467758,
0.00459382776170969,
-0.012336303479969501,
-0.03020733967423439,
-0.031363483518362045,
-0.0475987009704113,
0.0017495903884992003,
-0.0017219168366864324,
-0.021831445395946503,
-0.056478869169950485,
-0.00677697267383337,
0.009286051616072655,
-0.06435049325227737,
0.01976514421403408,
0.02696029655635357,
-0.0030779263470321894,
-0.007760924752801657,
0.0020124902948737144,
-0.008591135032474995,
0.0012891314690932631,
0.0556425116956234,
0.038497138768434525,
-0.048336662352085114,
0.042014770209789276,
-0.02499239146709442,
-0.036529235541820526,
-0.028042644262313843,
-0.006598630920052528,
0.0278212558478117,
-0.006109729874879122,
0.021425563842058182,
0.03992386907339096,
0.042408350855112076,
0.024574212729930878,
-0.027255482971668243,
0.019223971292376518,
-0.019322365522384644,
0.003210144815966487,
0.026345327496528625,
0.015423454344272614,
0.06016869097948074,
-0.0006057457067072392,
-0.006162002217024565,
0.008302099071443081,
-0.007471888791769743,
0.018891887739300728,
-0.027673661708831787,
0.006414140108972788,
-0.012004219926893711,
-0.013381753116846085,
0.023479565978050232,
0.0187073964625597,
0.012176411226391792,
0.002169307554140687,
0.027476871386170387,
-0.00915690790861845,
0.04961580038070679,
-0.0035268545616418123,
0.046836137771606445,
0.06597401201725006,
0.05175589770078659,
0.05810239166021347,
0.08235681802034378,
-0.035668276250362396,
0.08161885291337967,
-0.006389541085809469,
-0.027526069432497025,
0.0019556055776774883,
-0.020712198689579964,
-0.021733049303293228,
-0.008172955363988876,
-0.04592598229646683,
-0.031092897057533264,
-0.006979912519454956,
-0.02511538565158844,
-0.022557109594345093,
-0.027476871386170387,
-0.015509550459682941,
0.029666166752576828,
0.0045538549311459064,
-0.03099450282752514,
-0.006512535270303488,
-0.05849597230553627,
-0.01638280786573887,
-0.05352701246738434,
0.02523837983608246,
0.008714129216969013,
-0.011383099481463432,
-0.0036129504442214966,
0.0109710693359375,
-0.0004373975971248001,
-0.04413026571273804,
0.03630784526467323,
-0.012471597641706467,
-0.0321260467171669,
-0.012465447187423706,
-0.008941668085753918,
0.009015464223921299,
-0.026689710095524788,
-0.019346965476870537,
0.01275448314845562,
0.0003174784069415182,
-0.032347436994314194,
0.014587095007300377,
-0.006918415427207947,
0.019617551937699318,
-0.04169498383998871,
0.009888721629977226,
-0.008732577785849571,
0.02062610350549221,
-0.008535787463188171,
0.01202881895005703,
-0.010989518836140633,
0.03087150864303112,
-0.04634416103363037,
-0.026394523680210114,
0.02942017838358879,
0.014414903707802296,
-0.02129027061164379,
0.006629379466176033,
0.003107137279585004,
-0.008148356340825558,
-0.025152284651994705,
-0.04381048306822777,
0.015546448528766632,
-0.011044866405427456,
-0.021450163796544075,
0.010313051752746105,
-0.006998361553996801,
0.01903948001563549,
0.022188127040863037,
0.005891415290534496,
-0.0005173437530174851,
-0.013529346324503422,
0.00027020255220122635,
-0.01424271147698164,
-0.020650701597332954,
0.024008439853787422,
0.020650701597332954,
-0.007330445572733879,
0.004710672423243523,
-0.04693453013896942,
-0.011696734465658665,
-0.022655505686998367,
0.0048613399267196655,
0.033946357667446136,
0.013873729854822159,
0.0059990352019667625,
0.026788106188178062,
-0.04063723608851433,
0.005682325456291437,
-0.0023737852461636066,
-0.007810122333467007,
-0.03131428733468056,
-0.00726894848048687,
0.024242129176855087,
0.029764560982584953,
-0.0027996522840112448,
-0.0397762767970562,
-0.020380115136504173,
0.018399911001324654,
-0.03318379446864128,
-0.013307956978678703,
-0.0207613967359066,
-0.01400902308523655,
0.018609000369906425,
0.04216236248612404,
-0.014808484353125095,
-0.005116552580147982,
0.029297184199094772,
-0.005516283214092255,
-0.01811702363193035,
-0.017600448802113533,
-0.0015051397494971752,
-0.015214364975690842,
-0.006303445436060429,
-0.0010377623839303851,
-0.011297004297375679,
-0.031117497012019157,
0.0041080014780163765,
0.004981259349733591,
0.0025152284651994705,
0.014796185307204723,
0.03357737883925438,
0.005556256510317326,
0.0033362137619405985,
-0.011813579127192497,
-0.01371383760124445,
0.02366405725479126,
0.018916485831141472,
-0.008628033101558685,
-0.0015258949715644121,
-0.0014451801544055343,
0.006146627943962812,
-0.00538713950663805,
0.02002343162894249,
0.03458592668175697,
-0.0024029964115470648,
-0.02206513285636902,
0.027378477156162262,
0.0016050724079832435,
-0.02550896629691124,
-0.006266547366976738,
-0.0024783301632851362,
-0.008431242778897285,
-0.040489643812179565,
-0.026788106188178062,
0.002112422836944461,
-0.04216236248612404,
-0.008246751502156258,
-0.030551724135875702,
0.006592481397092342,
0.019789744168519974,
0.044179465621709824,
0.06312055140733719,
-0.020011132583022118,
0.016567299142479897,
-0.0021892942022532225,
-0.007890068925917149,
-0.024635709822177887,
0.0168501865118742,
0.013664639554917812,
0.001009320025332272,
-0.01737906038761139,
-0.007920817472040653,
0.068975068628788,
0.038177356123924255,
-0.016026126220822334,
-0.02538597397506237,
-0.01384913083165884,
0.013406352140009403,
0.03219984471797943,
-0.025361374020576477,
-0.030059747397899628,
0.006610930431634188,
-0.018338413909077644,
0.0020124902948737144,
-0.02543517015874386,
-0.0011884301202371716,
0.010626686736941338,
0.00028845950146205723,
0.00935369823127985,
0.011290854774415493,
-0.002386084757745266,
-0.03033033385872841,
-0.018719695508480072,
-0.0016650320030748844,
-0.020908989012241364,
0.013283357955515385,
0.0031916957814246416,
0.00707215815782547,
0.0013137302594259381,
-0.0007648692699149251,
-0.006617080420255661,
-0.0057038492523133755,
0.021769948303699493,
0.014722388237714767,
0.01672719232738018,
-0.037439391016960144,
-0.004357064608484507,
-0.015706341713666916,
-0.017895635217428207,
-0.02538597397506237,
0.027181686833500862,
0.03072391450405121,
0.018547503277659416,
0.0014959152322262526,
-0.024869397282600403,
-0.01677638851106167,
-0.01427960954606533,
0.02089668996632099,
-0.004393962677568197,
0.013836830854415894,
0.009710380807518959,
0.020835192874073982,
0.008111458271741867,
0.008830972947180271,
-0.020982785150408745,
-0.01573093980550766,
0.03126508742570877,
0.01252079475671053,
-0.03033033385872841,
0.039825476706027985,
-0.039235103875398636,
-0.007939266040921211,
-0.04078482836484909,
-0.014562495984137058,
-0.02226192317903042,
0.005952912382781506,
-0.015066771768033504,
0.003256267635151744,
-0.024377422407269478,
-0.0211549773812294,
0.011715183965861797,
-0.012742184102535248,
0.008289799094200134,
-0.015607945621013641,
-0.015165166929364204,
-0.000697222538292408,
-0.029912155121564865,
0.053379420191049576,
0.026542117819190025,
0.0045015825890004635,
0.013467849232256413,
-0.03306080400943756,
0.005946762394160032,
0.00931680016219616,
-0.017268365249037743,
-0.03141268342733383,
-0.010110110975801945,
-0.047032926231622696,
-0.020798295736312866,
-0.02609933912754059,
-0.025484368205070496,
-0.005061205476522446,
-0.036922816187143326,
-0.012219459749758244,
0.03190465644001961,
-0.010091662406921387,
0.004292492754757404,
0.009974817745387554,
0.03766078129410744,
-0.009458242915570736,
-0.010854225605726242,
0.01956835389137268,
-0.02710789069533348,
-0.02636992558836937,
0.0023906968999654055,
-0.020207922905683517,
0.03372497111558914,
0.034192346036434174,
-0.014218112453818321,
0.05018157511949539,
-0.017329862341284752,
0.025078488513827324,
-0.022889193147420883,
0.01533735916018486,
-0.02961696870625019,
0.0004127988067921251,
-0.00578379537910223,
0.015325059182941914,
-0.015103669837117195,
0.035004109144210815,
-0.01824001781642437,
-0.0006422596052289009,
-0.006863068323582411,
-0.012705286033451557,
-0.025066189467906952,
0.03256882727146149,
0.007416541688144207,
0.02213893085718155,
0.017243767157197,
-0.09101559966802597,
-0.02228652313351631,
0.010460644029080868,
0.024217529222369194,
0.0053071933798491955,
0.009870273061096668,
-0.013172663748264313,
-0.00915075745433569,
-0.011297004297375679,
-0.00622964883223176,
0.004443160258233547,
-0.03315919637680054,
0.026123937219381332,
-0.002715093782171607,
-0.0012699136277660728,
-0.008800224401056767,
-0.02484479919075966,
-0.055150534957647324,
0.016690293326973915,
0.00465840008109808,
-0.0005542419385164976,
0.03146187961101532,
0.024402020499110222,
0.037980563938617706,
-0.011690584942698479,
0.0491730235517025,
-0.00588526576757431,
0.012606890872120857,
-0.021204175427556038,
-0.017686545848846436,
0.014574795961380005,
-0.00207398715429008,
-0.007035260088741779,
0.05273985117673874,
-0.03556988015770912,
-0.045311011373996735,
0.013086567632853985,
-0.030846908688545227,
0.006567882373929024,
0.012465447187423706,
0.029321782290935516,
-0.001376764732412994,
0.017268365249037743,
0.029444776475429535,
0.019789744168519974,
-0.004529255907982588,
-0.046098172664642334,
0.000003903619926859392,
0.02365175634622574,
-0.010583638213574886,
0.03475812077522278,
-0.011948872357606888,
-0.017686545848846436,
-0.012803681194782257,
0.016936281695961952,
0.004566154442727566,
0.0027550668455660343,
0.023159781470894814,
0.017944833263754845,
-0.016702592372894287,
-0.018731994554400444,
0.041670385748147964,
0.03424154594540596,
-0.027280081063508987,
-0.012244057841598988,
-0.0048613399267196655,
-0.04044044390320778,
0.004393962677568197,
-0.011788980104029179,
0.02617313526570797,
-0.02002343162894249,
0.014943777583539486,
-0.027452273294329643,
0.02049081027507782,
-0.03141268342733383,
0.011549142189323902,
-0.010067063383758068,
-0.00401268107816577,
0.0025152284651994705,
-0.008732577785849571,
-0.023811649531126022,
-0.02664051204919815,
-0.005048905964940786,
-0.012791382148861885,
-0.0362340472638607,
0.01751435361802578,
-0.007970014587044716,
-0.009673482738435268,
0.02750147134065628,
-0.008480439893901348,
-0.004138750024139881,
-0.03989927098155022,
-0.00819755345582962,
-0.0006768516614101827,
-0.005055055487900972,
-0.02809184230864048,
-0.04235915467143059,
-0.0016312086954712868,
0.009341398254036903,
-0.018055526539683342,
0.024967793375253677,
-0.030035149306058884,
-0.02446351759135723,
-0.051067132502794266,
-0.026148537173867226,
-0.006321894470602274,
0.032495029270648956,
0.006524834781885147,
0.0036836720537394285,
-0.06681036949157715,
0.023319672793149948,
-0.003366962308064103,
0.0064018405973911285,
-0.018867287784814835,
0.00958738662302494,
0.024106834083795547,
0.020466210320591927,
-0.008474290370941162,
0.0532810240983963,
-0.03547148406505585,
0.03237203508615494,
0.01355394534766674,
-0.004206396639347076,
-0.026714308187365532,
-0.0016066099051386118,
-0.005420962814241648,
0.010313051752746105,
0.01651810109615326,
0.02954317256808281,
-0.034659724682569504,
0.007465739268809557,
-0.004916687496006489,
0.006961463484913111,
-0.013209561817348003,
-0.0065002357587218285,
0.01931006647646427,
0.0018771968316286802,
0.024955494329333305,
-0.023085983470082283,
0.006789271719753742,
0.004307867027819157,
0.008664931170642376,
0.02195443958044052,
-0.01410741824656725,
0.0021400966215878725,
-0.019482258707284927,
-0.031634069979190826,
0.011592189781367779,
-0.017145371064543724,
0.007933116517961025,
-0.04277733340859413,
0.0051411516033113,
0.02074909768998623,
0.029789160937070847,
-0.004037280101329088,
0.04046504572033882,
0.03131428733468056,
-0.014550196938216686,
-0.029592370614409447,
0.014070520177483559,
0.006014409475028515,
0.059381529688835144,
0.002771978499367833,
-0.017108473926782608,
0.027673661708831787,
0.011266255751252174,
0.006918415427207947,
-0.0009685782133601606,
0.018916485831141472,
0.021511660888791084,
0.05844677612185478,
-0.022790798917412758,
0.04818907007575035,
-0.01420581340789795,
-0.031215891242027283,
-0.025127684697508812,
0.045630794018507004,
0.036529235541820526,
0.020404713228344917,
-0.009722679853439331,
-0.03013354353606701,
-0.004486208315938711,
0.019396163523197174,
0.03588966652750969,
0.018547503277659416,
0.008578835055232048,
-0.016616497188806534,
-0.04267893731594086,
0.011875076219439507,
0.03303620219230652,
-0.039751678705215454,
-0.03682442009449005,
0.026074739173054695,
0.07025420665740967,
0.021167276427149773,
-0.004270968493074179,
-0.04634416103363037,
-0.0005915245274081826,
-0.02147476188838482,
-0.027919650077819824,
-0.03345438465476036,
0.036061856895685196,
0.03013354353606701,
-0.002821176080033183,
-0.006789271719753742,
0.016751790419220924,
0.017760341987013817,
-0.035717472434043884,
0.013221860863268375,
0.04813987389206886,
0.0023092133924365044,
0.0215485580265522,
-0.056085288524627686,
0.0366276316344738,
0.0016435080906376243,
-0.03079771250486374,
0.006740074139088392,
0.022766198962926865,
-0.032691821455955505,
-0.00707215815782547,
-0.05273985117673874,
-0.014783885329961777,
-0.016493503004312515,
-0.011788980104029179,
-0.019396163523197174,
0.03052712418138981,
0.016616497188806534,
0.0048644146881997585,
-0.000043768588511738926,
0.00895396713167429,
-0.04012066125869751,
0.020933588966727257,
0.018879586830735207,
-0.010645135305821896,
0.0064571877010166645,
-0.002747379709035158,
-0.036652229726314545,
-0.019740546122193336,
0.0076010324992239475,
-0.005316418129950762,
0.03748858720064163,
-0.021400965750217438,
0.01778494007885456,
0.003330064006149769,
-0.003945034462958574,
-0.014820783399045467,
0.06710555404424667,
-0.024229828268289566,
0.004218696150928736,
-0.01758814975619316,
0.0018233868759125471,
0.0044031874276697636,
0.009562787599861622,
0.021118080243468285,
0.0779782310128212,
0.010110110975801945,
0.004427785985171795,
0.01196732185781002,
0.024377422407269478,
-0.005974436178803444,
-0.011383099481463432,
-0.0012061104644089937,
0.028903603553771973,
-0.011979620903730392,
0.042924925684928894,
-0.042605139315128326,
0.01917477324604988,
-0.0013706149766221642,
0.014710089191794395,
0.02181914635002613,
0.029592370614409447,
0.011911974288523197,
0.021782247349619865,
0.02750147134065628,
0.004470834042876959,
-0.008049961179494858,
0.03424154594540596,
-0.012268656864762306,
-0.011303153820335865,
0.014168915338814259,
-0.009095410816371441,
-0.026468321681022644,
-0.03839874267578125,
-0.004092627204954624,
0.008252901025116444,
0.010374548844993114,
-0.010288452729582787,
0.016087623313069344,
-0.004735270980745554,
-0.03537309169769287,
-0.005577780306339264,
-0.0035945011768490076,
-0.021843744441866875,
-0.032347436994314194,
-0.008302099071443081,
-0.02003573253750801,
0.0024045337922871113,
-0.0011653687106445432,
0.0020570755004882812,
0.007631781045347452,
0.051116328686475754,
0.02109348028898239,
-0.008707978762686253,
-0.040145259350538254,
0.02313518151640892,
-0.015448053367435932,
-0.02366405725479126,
-0.022950690239667892,
0.035127103328704834,
-0.005408663768321276,
-0.04737731069326401,
0.03197845444083214,
-0.0023384245578199625,
0.015054472722113132,
0.03510250523686409,
0.017944833263754845,
-0.05392059311270714,
0.015890831127762794,
-0.003277791664004326,
0.030354933813214302,
-0.03411855176091194,
-0.019592953845858574,
-0.029764560982584953,
0.0048490408807992935,
-0.03197845444083214,
0.012668387964367867,
-0.00257057580165565,
-0.0007667910540476441,
0.008468140847980976,
0.010073212906718254,
0.011536842212080956,
0.0176373478025198,
0.01863360032439232,
0.037906769663095474,
0.016038425266742706,
0.011210908181965351,
0.008763326331973076,
-0.020576905459165573,
0.0008232914842665195,
0.012133363634347916,
-0.01381223276257515,
0.019777443259954453,
-0.006134328432381153,
0.013504747301340103,
0.007613332010805607,
0.027919650077819824,
0.021646954119205475,
0.005002783145755529,
-0.023381169885396957,
0.0008840197697281837,
0.054953742772340775,
-0.009365997277200222,
-0.036849018186330795,
0.06838469207286835,
-0.0033392885234206915,
0.007225900888442993,
-0.007275098469108343,
0.023553362116217613,
0.01381223276257515,
-0.0030487151816487312,
-0.03168326988816261,
0.03244583308696747,
0.00924915261566639,
-0.006245023105293512,
-0.028706813231110573,
0.025730356574058533,
-0.036258649080991745,
-0.02836242876946926,
0.0008978566038422287,
0.006967613473534584,
0.023110583424568176,
0.015251263044774532,
-0.04634416103363037,
0.022692402824759483,
-0.0003974245337303728,
0.0019525305833667517,
0.009655033238232136,
0.01261918991804123,
0.006574032362550497,
0.01252079475671053,
0.015202064998447895,
0.011542991735041142,
-0.00697376299649477,
-0.032888609915971756,
0.0020693750120699406,
-0.02617313526570797,
-0.014980675652623177,
-0.017096173018217087,
0.00677697267383337,
-0.031019100919365883,
0.011198609136044979,
-0.010190057568252087,
-0.014869981445372105,
-0.018928784877061844,
-0.027181686833500862,
-0.01976514421403408,
-0.011659836396574974,
0.00027942712767980993,
-0.009495140984654427,
-0.010233105160295963,
-0.00978417694568634,
0.003160947235301137,
0.01996193453669548,
-0.017206868156790733,
0.03534848988056183,
0.035127103328704834,
-0.015042172744870186,
0.0028165639378130436,
0.00951359048485756,
-0.00806226022541523,
-0.007133655250072479,
-0.017563551664352417,
-0.0560360923409462,
0.008129906840622425,
-0.04440085589885712,
-0.00509195402264595,
-0.023147480562329292,
-0.020933588966727257,
-0.029862957075238228,
-0.006936864927411079,
0.00593138812109828,
0.014648592099547386,
0.004489283077418804,
0.007391942664980888,
0.006641678977757692,
0.009993267245590687,
0.03628324717283249,
-0.011383099481463432,
-0.03699661046266556,
0.01242239959537983,
0.006078981328755617,
-0.004599977750331163,
-0.008382044732570648,
-0.018190821632742882,
-0.019617551937699318,
0.002562888665124774,
0.0025967119727283716,
0.027747459709644318,
0.00816065538674593,
0.04076023027300835,
-0.0026289978995919228,
-0.02458651177585125,
0.03404475376009941,
0.01388602890074253,
-0.00849888939410448,
-0.010817327536642551,
-0.00449543260037899,
0.015325059182941914,
0.030256537720561028,
0.05421578139066696,
0.026025542989373207,
0.026492919772863388,
-0.008345146663486958,
0.0048551904037594795,
-0.023172080516815186,
0.025533566251397133,
-0.0278212558478117,
-0.04922221973538399,
0.004581528715789318,
0.03020733967423439,
-0.038570936769247055,
-0.005922163836658001,
-0.005138076841831207,
0.005642352160066366,
-0.03001054935157299,
0.00543941231444478,
0.007004511542618275,
-0.024242129176855087,
-0.002562888665124774,
-0.02656671591103077,
-0.0009255302720703185,
0.02577955462038517,
0.020982785150408745,
-0.002838087733834982,
0.044917430728673935,
-0.01014085952192545,
0.04639335721731186,
0.003978857770562172,
0.00593446334823966,
-0.02109348028898239,
-0.02466030791401863,
0.0057007744908332825,
0.02162235416471958,
-0.004609202034771442,
0.03483191505074501,
0.032298240810632706,
-0.02848542295396328,
-0.020835192874073982,
0.03210144862532616,
-0.005900640040636063,
0.006567882373929024,
-0.029321782290935516,
-0.012170261703431606,
-0.018067827448248863,
-0.029715364798903465,
0.004673774354159832,
0.0031209741719067097,
0.012742184102535248,
-0.010472944006323814,
-0.011635237373411655,
-0.009821075014770031,
-0.0009831837378442287,
0.018080126494169235,
-0.0026997195091098547,
0.013541645370423794,
0.009913320653140545,
-0.02907579392194748,
-0.05116552859544754,
0.0397762767970562,
0.0352746956050396,
-0.002266165567561984,
-0.012938974425196648,
-0.0205646064132452,
0.02240951731801033,
0.04486823081970215,
-0.05352701246738434,
0.005897564813494682,
0.014267310500144958,
0.02942017838358879,
-0.016210615634918213,
0.002138559240847826,
0.018805790692567825,
0.005946762394160032,
-0.024684907868504524,
-0.006635529454797506,
-0.01271758507937193,
-0.02114267833530903,
0.01778494007885456,
-0.023565661162137985,
0.01183202862739563,
0.04304791986942291,
-0.006275771651417017,
0.010220806114375591,
-0.01677638851106167,
-0.016013825312256813,
0.05623288080096245,
-0.03128968924283981,
-0.012114914134144783,
-0.005405588541179895,
0.004366288892924786,
0.0103806983679533,
-0.014599394053220749,
0.0393826961517334,
0.015964629128575325,
0.0064940862357616425,
0.013197261840105057,
0.021991336718201637,
-0.046688541769981384,
-0.02789505198597908,
0.025927146896719933,
0.00792696699500084,
0.010731231421232224,
0.014697789214551449,
0.02333197183907032,
-0.004882864188402891,
-0.009765728376805782,
0.00257057580165565,
-0.018522905185818672,
-0.015718640759587288,
-0.004520031623542309,
0.03945649415254593,
-0.012391651049256325,
0.010657435283064842,
0.01255769282579422,
-0.004123375751078129,
-0.011253955774009228,
-0.00474449573084712,
-0.016419706866145134,
-0.00603285850957036,
0.0034561329521238804,
-0.014587095007300377,
-0.005291819106787443,
-0.016690293326973915,
0.0016204466810449958,
-0.008880170993506908,
0.0031378858257085085,
-0.007478038780391216,
0.01236090250313282,
-0.015607945621013641,
0.006856918800622225,
-0.03303620219230652,
0.011641387827694416,
-0.010485243052244186,
0.008086859248578548,
0.006118954159319401,
-0.01996193453669548,
-0.051657501608133316,
-0.019998833537101746,
-0.002815026557072997,
0.010294602252542973,
-0.05010777711868286,
0.003720570122823119,
0.012336303479969501,
-0.006171226967126131,
0.01007936242967844,
0.016887083649635315,
-0.011198609136044979,
-0.003019504016265273,
-0.019346965476870537,
-0.03345438465476036,
-0.01404592115432024,
0.029444776475429535,
-0.0034438336733728647,
-0.010952620767056942,
0.003886612132191658,
-0.001872584456577897,
0.008326697163283825,
-0.026788106188178062,
-0.036972012370824814,
0.005565480794757605,
-0.01087882462888956,
-0.005464010871946812,
-0.002796577289700508,
-0.01811702363193035,
-0.009261452592909336,
0.022913793101906776,
-0.03357737883925438,
0.02141326479613781,
-0.03170786798000336,
0.019223971292376518,
0.0311420951038599,
0.016099922358989716,
-0.014636293053627014,
0.022458715364336967,
0.03672602400183678,
0.02605014108121395,
0.009113859385251999,
0.01176438108086586,
0.013172663748264313,
-0.014697789214551449,
0.02585335075855255,
0.01573093980550766,
-0.010805027559399605,
-0.03067471832036972,
0.010485243052244186,
-0.0026705083437263966,
-0.007970014587044716,
0.003157872473821044,
-0.047106724232435226,
0.01653040200471878,
-0.0014636293053627014,
0.040686432272195816,
0.05928313359618187,
0.04139979928731918,
-0.05952912196516991,
-0.0014328807592391968,
-0.03131428733468056,
0.004187947604805231,
-0.005048905964940786,
-0.012108764611184597,
0.0028872855473309755,
0.048336662352085114,
0.018215419724583626,
0.005759196821600199,
0.015694040805101395,
-0.007428841199725866,
-0.024967793375253677,
0.0025259903632104397,
0.020244821906089783,
0.019974235445261,
0.007527236361056566,
-0.05121472477912903,
0.014058220200240612,
0.0017588150221854448,
0.02094588801264763,
0.000831747311167419,
0.015509550459682941,
-0.0019110201392322779,
-0.0032378186006098986,
-0.0022554034367203712,
-0.020146425813436508,
0.02399614080786705,
-0.011118662543594837,
-0.002555201528593898,
0.10075672715902328,
-0.03180626407265663,
-0.009003165178000927,
-0.0041110762394964695,
0.004741420969367027,
-0.04784468933939934,
0.011007968336343765,
0.002247716300189495,
0.026911098510026932,
-0.02148706093430519,
0.04924682155251503,
0.004332465585321188,
0.019715948030352592,
-0.004987408872693777,
0.031560275703668594,
-0.015903132036328316,
0.018867287784814835,
0.025927146896719933,
-0.013074268586933613,
-0.03333139047026634,
-0.01557104755192995,
-0.0060113342478871346,
-0.0030886882450431585,
0.005230322014540434,
0.010325350798666477,
-0.01837531104683876,
-0.008492739871144295,
-0.011426148004829884,
0.0033577377907931805,
0.008283649571239948,
0.007496487814933062,
-0.007484188303351402,
0.0023660981096327305,
-0.008056110702455044,
-0.00475679524242878,
-0.021425563842058182,
-0.0072935475036501884,
-0.0205646064132452,
0.007742475718259811,
-0.029789160937070847,
0.0052118729799985886,
0.015214364975690842,
-0.023221278563141823,
-0.0011092526838183403,
0.03416774794459343,
-0.01792023330926895,
-0.03608645498752594,
-0.00041894850437529385,
0.003929660189896822,
-0.03950569033622742,
0.00622964883223176,
-0.027255482971668243,
-0.0021016609389334917,
-0.0002354183088755235,
-0.049935586750507355,
-0.005368690472096205,
0.010983369313180447,
0.026271529495716095,
-0.0056054540909826756,
-0.03534848988056183,
-0.0192977674305439,
-0.0020693750120699406,
0.026935698464512825,
0.026197733357548714,
0.0000752858177293092
] | 2024-07-21 | 1 | 39032527 | [
"non-transduced T cells",
"T cells",
"retroviral copy numbers",
"ψ gene sequence",
"TaqMan real-time PCR dynamics",
"cancer immunotherapy",
"cancer therapy",
"CAR",
"a TaqMan real-time qPCR method",
"reactivity",
"Retrovirus-mediated gene transfer",
"the specific CAR expressing cassette",
"basic research and clinical contests",
"primers",
"PCR",
"qPCR",
"the diverse CAR constructs",
"CAR-T",
"a precise and validated quantitative methodology",
"the integrated DNA level",
"tissues",
"a paradigm shift",
"y = -3.3841x",
"Chimeric-antigen-receptor-T",
"The regression equation",
"a swift, sensitive, reproducible, and accurate tool",
"This method",
"a spectrum",
"no cross",
"the landscape"
] | [
"CAR-T",
"In vivo",
"Retrovirus",
"TaqMan realtime PCR"
] | 0 | 10.1016/j.ab.2024.115626 | [
"Hu",
"Cheng",
"Cao",
"Guo",
"Duan",
"Jin",
"Zhang",
"Wang",
"Liu"
] | [
"National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, PR China.",
"National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, PR China.",
"National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, PR China.",
"National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, PR China.",
"National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, PR China.",
"National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, PR China.",
"National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, PR China.",
"National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, PR China.",
"National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, 430068, PR China; Wuhan Binhui Biopharmaceutical Co., Ltd. Wuhan, 430068, PR China. Electronic address: [email protected]."
] | [
"39032527"
] | [] | 8.738298 | 3.324093 |
39032146 | 710 | Novel chimeric antigen receptors for the effective and safe treatment of NY-BR-1 positive breast cancer. | null | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-20 | 12 | 39032146 | [] | [] | 0 | 10.1002/ctm2.1776
10.1126/science.aaa4967
10.3390/cancers15030663
10.1158/1078-0432.CCR-05-2192
10.1002/ijc.23241
10.1002/ijc.22620
10.1126/sciadv.abf1333
10.1080/19420862.2017.1323159
10.1126/science.aba1624
10.1038/mt.2011.9
10.1158/1078-0432.CCR-18-0426 | [
"Jäger",
"Berger",
"Tuch",
"Luckner-Minden",
"Eurich",
"Hlevnjak",
"Schneeweiss",
"Lichter",
"Aulmann",
"Heussel",
"Fremd",
"Harbottle",
"Zörnig",
"Schmidt"
] | [
"Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.\nClinical Cooperation Unit \"Applied Tumor Immunity\", German Cancer Research Center (DKFZ), Heidelberg, Germany.",
"Clinical Cooperation Unit \"Applied Tumor Immunity\", German Cancer Research Center (DKFZ), Heidelberg, Germany.",
"Clinical Cooperation Unit \"Applied Tumor Immunity\", German Cancer Research Center (DKFZ), Heidelberg, Germany.",
"Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.",
"Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.",
"Computational Oncology Group, Molecular Precision Oncology Program, NCT and DKFZ, Heidelberg, Germany.",
"Division of Gynecological Oncology, NCT, University Hospital Heidelberg, Heidelberg, Germany.\nDivision of Molecular Genetics, DKFZ, Heidelberg, Germany.\nNCT Heidelberg, a partnership between DKFZ and Heidelberg University Medical Center, Heidelberg, Germany.",
"German Cancer Consortium (DKTK), Heidelberg, Germany.",
"Institute for Pathology, University Hospital Heidelberg, Heidelberg, Germany.",
"Department of Diagnostics and Interventional Radiology, Thoraxklinik Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.",
"Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.\nDivision of Gynecological Oncology, NCT, University Hospital Heidelberg, Heidelberg, Germany.\nDivision of Molecular Genetics, DKFZ, Heidelberg, Germany.\nNCT Heidelberg, a partnership between DKFZ and Heidelberg University Medical Center, Heidelberg, Germany.",
"DNA Vector Lab, DKFZ, Heidelberg, Germany.\nGMP and T Cell Therapy Group, DKFZ, Heidelberg, Germany.",
"Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.",
"Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.\nDNA Vector Lab, DKFZ, Heidelberg, Germany."
] | [
"39032146",
"25838374",
"36765623",
"16675566",
"18041742",
"17330232",
"33853779",
"28463043",
"36520915",
"21326215",
"30097433",
"15585893"
] | [] | 32.936584 | 7.467575 |
39028827 | 711 | CD5 deletion enhances the antitumor activity of adoptive T cell therapies. | Most patients treated with US Food and Drug Administration (FDA)-approved chimeric antigen receptor (CAR) T cells eventually experience disease progression. Furthermore, CAR T cells have not been curative against solid cancers and several hematological malignancies such as T cell lymphomas, which have very poor prognoses. One of the main barriers to the clinical success of adoptive T cell immunotherapies is CAR T cell dysfunction and lack of expansion and/or persistence after infusion. In this study, we found that CD5 inhibits CAR T cell activation and that knockout (KO) of CD5 using CRISPR-Cas9 enhances the antitumor effect of CAR T cells in multiple hematological and solid cancer models. Mechanistically, CD5 KO drives increased T cell effector function with enhanced cytotoxicity, in vivo expansion, and persistence, without apparent toxicity in preclinical models. These findings indicate that CD5 is a critical inhibitor of T cell function and a potential clinical target for enhancing T cell therapies. | [
0.01285470649600029,
0.0390130914747715,
0.022531181573867798,
0.06351737678050995,
-0.01472147461026907,
-0.009274765849113464,
0.005821835249662399,
-0.002614066004753113,
0.015749378129839897,
-0.036768242716789246,
0.004082078579813242,
-0.005691870581358671,
-0.06692009419202805,
0.010338114574551582,
0.01475691981613636,
-0.04083259776234627,
0.025756673887372017,
-0.006563225761055946,
0.039674729108810425,
0.05770440027117729,
0.00015017957775853574,
0.012323032133281231,
0.014745105057954788,
0.029466580599546432,
-0.032325807958841324,
-0.022472107782959938,
0.04567674174904823,
0.028993980959057808,
-0.02627653256058693,
-0.019329320639371872,
0.034476134926080704,
-0.019412025809288025,
-0.045629482716321945,
-0.015820268541574478,
-0.03475969284772873,
0.02634742297232151,
0.059878360480070114,
0.0071953278966248035,
-0.01200402807444334,
-0.02438613586127758,
0.06035095825791359,
0.007573407143354416,
0.0002817136119119823,
0.06039821729063988,
-0.056333862245082855,
-0.021361498162150383,
0.003257982898503542,
-0.0350668840110302,
-0.029679249972105026,
0.016753653064370155,
-0.03249121829867363,
-0.005172010976821184,
0.003411577781662345,
0.035303182899951935,
-0.04681098088622093,
0.03591756522655487,
-0.008152341470122337,
-0.005204502027481794,
-0.02000277489423752,
0.0029242094606161118,
0.0401473306119442,
-0.02190498821437359,
-0.0014015529304742813,
-0.02837960049510002,
-0.06139067932963371,
-0.007910134270787239,
-0.06488791108131409,
-0.05269484594464302,
-0.026701873168349266,
0.02653646282851696,
-0.021881358698010445,
-0.03272751718759537,
-0.0003071896790061146,
0.0011202085297554731,
0.03289292752742767,
0.013705385848879814,
0.03761892020702362,
0.017332587391138077,
0.043030187487602234,
-0.00701219541952014,
0.01901031658053398,
0.025236815214157104,
0.0058484189212322235,
-0.06252491474151611,
-0.010586229152977467,
-0.0074198124930262566,
-0.00302316015586257,
-0.0439281240105629,
-0.03551585227251053,
-0.017143547534942627,
0.02627653256058693,
0.024362504482269287,
-0.05463250353932381,
0.04799248278141022,
0.012358477339148521,
0.007478887215256691,
-0.008619033731520176,
-0.056900981813669205,
0.03520866483449936,
0.022968336939811707,
0.02116064354777336,
0.015749378129839897,
-0.038162410259246826,
-0.017876077443361282,
0.030742598697543144,
0.009700105525553226,
-0.057090021669864655,
-0.03806789219379425,
-0.010745731182396412,
-0.006439168471843004,
0.07722276449203491,
-0.008193694055080414,
-0.02875768020749092,
0.05387634411454201,
-0.046763721853494644,
-0.05449072644114494,
-0.023346416652202606,
0.005393541883677244,
-0.016552798449993134,
0.009895052760839462,
-0.0010973169701173902,
0.049292128533124924,
0.018265971913933754,
-0.024646064266562462,
0.004445389378815889,
-0.005786390509456396,
0.09277128428220749,
-0.008453624323010445,
-0.033861756324768066,
-0.04222676530480385,
0.018584975972771645,
0.0020513772033154964,
0.02570941299200058,
-0.025614893063902855,
-0.04187231883406639,
0.004191366955637932,
-0.025662153959274292,
-0.012972856871783733,
-0.035114143043756485,
0.01475691981613636,
-0.009357470087707043,
-0.028403231874108315,
0.012653851881623268,
-0.012358477339148521,
-0.02819056063890457,
-0.042959295213222504,
0.006214683875441551,
0.03045903891324997,
0.00674635823816061,
0.02324008196592331,
0.007171697914600372,
0.04142334684729576,
0.06602215021848679,
-0.016292868182063103,
-0.015123184770345688,
-0.03804426267743111,
0.013091006316244602,
0.043857235461473465,
-0.052411288022994995,
-0.05515236407518387,
-0.0011733759893104434,
0.0018076931592077017,
-0.030057329684495926,
0.0051011210307478905,
0.027079952880740166,
0.014296135865151882,
0.009044373407959938,
0.015572153963148594,
-0.04704728350043297,
-0.007343015167862177,
-0.016351943835616112,
-0.04156512767076492,
-0.08790350705385208,
-0.030766228213906288,
-0.055435921996831894,
-0.003656738670542836,
-0.0013291861396282911,
0.024811474606394768,
-0.031073417514562607,
-0.01212217751890421,
0.03745351359248161,
0.02185772731900215,
0.023594530299305916,
0.00440108310431242,
-0.009995480068027973,
-0.008376826532185078,
-0.01010181475430727,
0.03060081973671913,
-0.040690816938877106,
-0.016245609149336815,
0.039485689252614975,
-0.01257114764302969,
0.05099348723888397,
-0.017049027606844902,
-0.020735304802656174,
0.01364631112664938,
0.02660735324025154,
0.014012576080858707,
-0.02875768020749092,
-0.019849179312586784,
0.005718454252928495,
-0.013906240463256836,
-0.04477880522608757,
0.009646937251091003,
-0.011141533963382244,
-0.008229139260947704,
-0.0431719645857811,
0.04558222368359566,
-0.026300163939595222,
0.01551307924091816,
0.03038814850151539,
0.013587236404418945,
-0.018537716940045357,
0.014343395829200745,
-0.03230217844247818,
-0.026394683867692947,
-0.007307569961994886,
0.05198594555258751,
0.023074671626091003,
0.056144822388887405,
-0.013551791198551655,
-0.021609613671898842,
0.017249882221221924,
0.004362684208899736,
-0.035114143043756485,
-0.004058448597788811,
0.009635122492909431,
-0.008317751809954643,
-0.020853454247117043,
-0.004173644352704287,
-0.033530935645103455,
0.02875768020749092,
0.04154149815440178,
-0.02306285686790943,
-0.05066267028450966,
-0.013055562041699886,
0.01841956563293934,
0.029112130403518677,
0.04801611229777336,
-0.007862874306738377,
-0.02001458965241909,
-0.005990198813378811,
0.05415990576148033,
-0.020120924338698387,
-0.015312224626541138,
0.004528094083070755,
-0.005783436819911003,
-0.05902767926454544,
0.0058513726107776165,
0.0005726576782763004,
0.05066267028450966,
0.00013254939403850585,
-0.010798899456858635,
0.005827742628753185,
0.015264964662492275,
0.017935151234269142,
0.06800707429647446,
-0.036390163004398346,
0.002947839442640543,
0.00039063303847797215,
0.008672201074659824,
-0.009605585597455502,
-0.025614893063902855,
-0.046385642141103745,
-0.02755255252122879,
0.017757926136255264,
-0.007886504754424095,
0.00832365918904543,
0.006173331290483475,
-0.029348429292440414,
0.07306388765573502,
0.003473606426268816,
0.02236577309668064,
-0.002377766417339444,
-0.04437709599733353,
0.027623441070318222,
0.002556468127295375,
0.0401473306119442,
-0.006202868651598692,
0.011962675489485264,
-0.028214192017912865,
0.023901721462607384,
-0.021456018090248108,
-0.0175334420055151,
-0.018478641286492348,
-0.011767728254199028,
0.013717200607061386,
0.01219306793063879,
0.001400814508087933,
-0.04028910771012306,
-0.005437848158180714,
0.00801056157797575,
-0.011791357770562172,
-0.011395555920898914,
-0.030931638553738594,
0.0335545651614666,
-0.008855333551764488,
-0.006397815886884928,
-0.05444346368312836,
0.016611872240900993,
-0.03570489212870598,
0.03426346555352211,
-0.011419185437262058,
-0.05458524450659752,
-0.00022688468743581325,
-0.021125199273228645,
0.04047814756631851,
-0.013327306136488914,
0.009475620463490486,
0.05964205786585808,
-0.016044754534959793,
0.004536955617368221,
0.03078985959291458,
0.03705180063843727,
-0.019471099600195885,
0.014177985489368439,
0.01251207198947668,
-0.05628660321235657,
0.039296649396419525,
-0.021680502220988274,
-0.0478743314743042,
-0.02386627532541752,
-0.06625845283269882,
0.030364518985152245,
0.01622197777032852,
-0.031451497226953506,
0.02210584282875061,
0.009221598505973816,
-0.006120163947343826,
-0.03038814850151539,
0.03969835862517357,
-0.056522902101278305,
0.03965109959244728,
-0.017497997730970383,
-0.025662153959274292,
-0.015406744554638863,
-0.04967020824551582,
-0.011874062940478325,
0.02819056063890457,
0.019612880423665047,
-0.011513705365359783,
0.045511335134506226,
-0.06233587488532066,
0.07509606331586838,
0.000091796915512532,
-0.019293874502182007,
-0.0025638523511588573,
0.010314484126865864,
-0.0038310098461806774,
0.024622434750199318,
0.02533133514225483,
0.03294018656015396,
-0.00655731838196516,
0.013327306136488914,
0.005210409872233868,
0.058366041630506516,
-0.03542133420705795,
-0.0007945579709485173,
0.01345727127045393,
0.012606591917574406,
0.03019910864531994,
0.024078944697976112,
-0.0440935343503952,
0.03142786771059036,
0.053167447447776794,
0.06734543293714523,
-0.0348542146384716,
0.02875768020749092,
-0.021326053887605667,
-0.028025152161717415,
-0.03979288041591644,
-0.02672550268471241,
0.04298292472958565,
0.0011054398491978645,
-0.035823043435811996,
0.027339883148670197,
0.01779337227344513,
0.018762201070785522,
0.0235590860247612,
-0.02209402807056904,
0.03870590031147003,
-0.03475969284772873,
-0.010562599636614323,
-0.01654098369181156,
0.008725368417799473,
0.0037099062465131283,
0.008441808633506298,
-0.00015156414883676916,
-0.0697556883096695,
0.021775022149086,
0.005452617071568966,
-0.004858913831412792,
0.02660735324025154,
-0.01424887590110302,
-0.0010832867119461298,
0.06299751251935959,
-0.021928617730736732,
0.09589044004678726,
0.03343641757965088,
-0.001998209860175848,
0.027977891266345978,
-0.0644625723361969,
-0.03041177988052368,
-0.009162522852420807,
0.006309203803539276,
-0.009428360499441624,
0.03329463675618172,
-0.023157376796007156,
0.010538969188928604,
-0.015690304338932037,
0.04451887309551239,
0.0039550671353936195,
0.03154601901769638,
0.002902056323364377,
-0.01576119475066662,
-0.03008095920085907,
-0.023535456508398056,
-0.002346751978620887,
-0.01912846602499485,
0.019648324698209763,
-0.0020499003585428,
-0.009268858470022678,
0.029537469148635864,
-0.005880910437554121,
-0.012110362760722637,
0.007153975311666727,
0.011708653531968594,
0.0167772825807333,
0.010911141522228718,
-0.045322295278310776,
-0.023783570155501366,
0.03958021104335785,
0.024669695645570755,
0.0013003870844841003,
0.012594777159392834,
0.017202623188495636,
-0.044944215565919876,
-0.0034204390831291676,
-0.06649475544691086,
-0.0014118910767138004,
-0.047590769827365875,
-0.007278032600879669,
0.03097889944911003,
-0.021822283044457436,
0.025236815214157104,
0.02001458965241909,
0.025189554318785667,
0.006332833785563707,
-0.035185035318136215,
0.008453624323010445,
-0.027458032593131065,
-0.012500257231295109,
-0.0072130500338971615,
-0.015016850084066391,
-0.039178501814603806,
0.004504464101046324,
0.038398709148168564,
-0.03783159330487251,
0.017462551593780518,
0.032278548926115036,
-0.0007561592501588166,
-0.05023732781410217,
0.0009703058749437332,
-0.03336552530527115,
-0.022684777155518532,
0.033601824194192886,
0.06890501081943512,
-0.0175334420055151,
0.010308576747775078,
-0.040950749069452286,
0.01437884010374546,
-0.0022315557580441236,
-0.002899102633818984,
0.025567634031176567,
-0.006007921416312456,
0.057420842349529266,
0.019908254966139793,
0.02823782153427601,
0.00027303697424940765,
-0.010344021953642368,
0.0013048177352175117,
-0.02552037499845028,
-0.01817145198583603,
0.006976750213652849,
0.04350278526544571,
0.04267573729157448,
-0.005638703238219023,
-0.009599677287042141,
-0.017391663044691086,
0.045889414846897125,
0.01850227080285549,
-0.03837507963180542,
0.020428113639354706,
-0.010828436352312565,
-0.02090071327984333,
0.014638770371675491,
0.019719215109944344,
0.009806440211832523,
0.003509051399305463,
0.014839624986052513,
0.03064807876944542,
0.02134968340396881,
0.005736176855862141,
-0.02127879299223423,
0.032656628638505936,
0.024315245449543,
0.03653194382786751,
0.025874823331832886,
0.019329320639371872,
0.01912846602499485,
-0.038611382246017456,
-0.02722173184156418,
0.03135697916150093,
-0.01647009328007698,
-0.05387634411454201,
-0.021479647606611252,
-0.05973657965660095,
-0.01621016301214695,
-0.010692563839256763,
0.015335854142904282,
-0.014520619995892048,
-0.003098480636253953,
0.01937657967209816,
0.026938172057271004,
-0.0014148447662591934,
-0.039367541670799255,
-0.034736063331365585,
-0.031687796115875244,
-0.0220467671751976,
-0.025945713743567467,
0.03924939036369324,
-0.010881603695452213,
0.029372060671448708,
0.030293628573417664,
-0.004870728589594364,
-0.042841147631406784,
-0.0412815697491169,
0.04832329973578453,
-0.01070437952876091,
-0.03026999905705452,
0.026252903044223785,
-0.03728810325264931,
0.029537469148635864,
-0.008353196084499359,
0.019719215109944344,
0.012464812025427818,
0.0038605474401265383,
-0.026867283508181572,
0.012559331953525543,
-0.020628968253731728,
0.015040479600429535,
-0.011029290966689587,
0.0023098301608115435,
0.006640023086220026,
0.016694577410817146,
-0.02483510412275791,
-0.007118530105799437,
-0.007933764718472958,
-0.009522880427539349,
-0.03211313858628273,
-0.012866522185504436,
-0.00024534561089240015,
0.022401217371225357,
-0.022956522181630135,
-0.030813489109277725,
0.010149074718356133,
0.006332833785563707,
-0.009765087626874447,
-0.012996486388146877,
0.02951383963227272,
-0.019033946096897125,
0.0013867842499166727,
-0.0004323547182139009,
-0.011974490247666836,
0.05288388580083847,
0.012228512205183506,
-0.01869131065905094,
0.022755667567253113,
0.0039550671353936195,
0.012405737303197384,
-0.011425093747675419,
-0.003937344532459974,
-0.009983665309846401,
0.038280561566352844,
-0.01513499952852726,
0.0024235493037849665,
-0.039178501814603806,
-0.012500257231295109,
-0.001413367921486497,
0.0020809147972613573,
0.009416545741260052,
0.01517044473439455,
0.04054903984069824,
0.024669695645570755,
-0.046456534415483475,
0.009351562708616257,
0.015973864123225212,
-0.008122804574668407,
-0.0031132493168115616,
-0.0022891538683325052,
-0.0016230839537456632,
-0.018951240926980972,
0.008884871378540993,
-0.051513347774744034,
-0.01342182606458664,
0.024669695645570755,
0.012263957411050797,
-0.019364764913916588,
0.0033259191550314426,
-0.012642037123441696,
0.06885775178670883,
0.014508805237710476,
-0.029159391298890114,
0.0058366041630506516,
0.03237306699156761,
-0.020794378593564034,
-0.01658824272453785,
0.001293002744205296,
-0.0032963815610855818,
-0.03728810325264931,
-0.027150843292474747,
-0.0038339635357260704,
-0.04286477714776993,
0.018573161214590073,
-0.004761440213769674,
-0.03702817112207413,
-0.012334847822785378,
0.018088746815919876,
-0.0035149590112268925,
0.002537268679589033,
-0.005216317251324654,
-0.02679639309644699,
-0.017060842365026474,
0.016694577410817146,
-0.006787710823118687,
-0.05070992931723595,
0.021550538018345833,
-0.01443791575729847,
-0.01671820878982544,
0.0015979771269485354,
-0.006515965797007084,
0.016954507678747177,
-0.011950860731303692,
0.0016865895595401525,
0.008754906244575977,
-0.011986305005848408,
-0.028214192017912865,
0.026441942900419235,
0.014544250443577766,
-0.003925529774278402,
0.004711226560175419,
-0.02065259963274002,
-0.0014096758095547557,
-0.036319274455308914,
0.007053548004478216,
-0.007532055024057627,
-0.0010832867119461298,
0.00503318477421999,
0.052978407591581345,
0.07292210310697556,
-0.011584595777094364,
0.016930878162384033,
0.000842556357383728,
-0.03475969284772873,
-0.009918682277202606,
-0.042912036180496216,
0.013563605956733227,
-0.00775653962045908,
0.023417307063937187,
-0.0026199736166745424,
0.050379108637571335,
0.022495737299323082,
-0.013126451522111893,
-0.026938172057271004,
-0.0019376580603420734,
0.013788091018795967,
0.01058032177388668,
-0.027339883148670197,
-0.017946965992450714,
0.01361086592078209,
-0.00931021012365818,
-0.006273758597671986,
-0.0386350117623806,
-0.06753446906805038,
0.0009274765616282821,
0.005296068266034126,
0.002343798289075494,
0.0014621047303080559,
0.008932131342589855,
-0.007898319512605667,
-0.001909597427584231,
-0.014048020355403423,
-0.028663160279393196,
0.012866522185504436,
-0.01722625270485878,
0.008908500894904137,
-0.007892412133514881,
-0.010267224162817001,
-0.009274765849113464,
-0.006716820877045393,
0.03615386411547661,
0.005461478140205145,
0.01767522282898426,
-0.015383114106953144,
0.012913782149553299,
-0.004536955617368221,
0.004061402287334204,
-0.023960795253515244,
-0.006096533965319395,
0.03589393198490143,
0.010586229152977467,
0.0299628097563982,
-0.03440524637699127,
-0.009522880427539349,
0.012665667571127415,
-0.006640023086220026,
-0.001531517831608653,
0.03683913126587868,
0.002085345331579447,
0.03249121829867363,
0.010279039852321148,
0.02077074907720089,
-0.017214437946677208,
0.017521627247333527,
0.03920213133096695,
-0.0114014632999897,
-0.042392175644636154,
0.060256440192461014,
-0.007130345329642296,
-0.004891404882073402,
-0.010450356639921665,
-0.023204635828733444,
-0.019364764913916588,
-0.008707646280527115,
-0.015064110048115253,
0.025095034390687943,
0.00018959362932946533,
0.0015566246584057808,
-0.011921322904527187,
-0.008187786675989628,
0.034547023475170135,
-0.014166170731186867,
0.0006435476243495941,
0.0072898478247225285,
-0.02386627532541752,
0.02311011590063572,
0.007632482331246138,
0.004912081174552441,
0.001188883208669722,
-0.029986439272761345,
0.0033081965520977974,
0.008240954019129276,
-0.0039609745144844055,
0.00920978281646967,
0.009440175257623196,
-0.028734050691127777,
0.0040998007170856,
0.013882610946893692,
-0.009239320643246174,
-0.009960034862160683,
-0.020380854606628418,
0.02001458965241909,
0.0005442278925329447,
-0.007786076981574297,
-0.00312801799736917,
0.007230772636830807,
-0.0068999528884887695,
0.011608225293457508,
-0.0018564299680292606,
0.004232719540596008,
-0.011584595777094364,
0.001922889263369143,
0.0063682785257697105,
-0.01475691981613636,
0.0002842981484718621,
0.019612880423665047,
-0.007650204934179783,
-0.006004967726767063,
-0.01989644020795822,
-0.003509051399305463,
-0.013185526244342327,
0.0002617758291307837,
-0.016505537554621696,
0.0029685157351195812,
-0.052411288022994995,
0.0037955648731440306,
0.021515093743801117,
0.021113382652401924,
-0.03272751718759537,
-0.03350730612874031,
-0.023275526240468025,
-0.001949473051354289,
-0.024905994534492493,
0.029844660311937332,
-0.020758934319019318,
0.011637763120234013,
0.05070992931723595,
-0.10331025719642639,
-0.008666293695569038,
0.001208082539960742,
0.006480521056801081,
0.010869788937270641,
-0.004442435689270496,
-0.012027657590806484,
-0.0008853856706991792,
0.014733290299773216,
-0.015985678881406784,
-0.015075924806296825,
-0.014922330155968666,
0.00832365918904543,
-0.01918753981590271,
-0.005984291434288025,
-0.04142334684729576,
-0.02849775180220604,
-0.0463620126247406,
-0.018951240926980972,
0.011560965329408646,
0.009168430231511593,
-0.014969590120017529,
-0.014768734574317932,
0.06838515400886536,
-0.0017781556816771626,
0.03343641757965088,
-0.02438613586127758,
-0.018006041646003723,
-0.058035220950841904,
0.013469086028635502,
0.0178051870316267,
0.00652187317609787,
-0.01734440214931965,
0.05236402526497841,
-0.0028149208519607782,
-0.05312018468976021,
0.032065875828266144,
-0.03483058512210846,
-0.03211313858628273,
-0.010231779888272285,
-0.020676229149103165,
-0.014886884950101376,
0.025095034390687943,
0.0008477253722958267,
-0.01994369924068451,
-0.013374566100537777,
-0.0644625723361969,
-0.02254299633204937,
0.011135626584291458,
-0.03336552530527115,
0.019400211051106453,
0.002054331125691533,
-0.01535948459059,
0.003438161453232169,
0.00021543892216868699,
-0.0181832667440176,
-0.012098548002541065,
0.03740625083446503,
0.02646557241678238,
-0.01118288654834032,
-0.004318377934396267,
0.06734543293714523,
0.025236815214157104,
-0.013244601897895336,
0.005804112646728754,
-0.022011322900652885,
-0.03289292752742767,
0.036626461893320084,
-0.03648468106985092,
-0.013941685669124126,
-0.009487435221672058,
0.0035238200798630714,
-0.04236854612827301,
0.044849693775177,
-0.03759529069066048,
0.018006041646003723,
-0.012606591917574406,
-0.012488442473113537,
-0.00013605697313323617,
0.03310559689998627,
-0.015843898057937622,
-0.003993466030806303,
-0.021810468286275864,
0.014154355973005295,
-0.0220467671751976,
0.025544004514813423,
-0.032774776220321655,
0.010722101666033268,
0.013185526244342327,
-0.019801920279860497,
0.0037748885806649923,
-0.004864821210503578,
-0.016009308397769928,
0.019329320639371872,
-0.02387809008359909,
-0.02305104210972786,
-0.006580948363989592,
-0.008264584466814995,
-0.0031811855733394623,
0.0005841034580953419,
0.04669283330440521,
-0.05439620465040207,
-0.0004408467502798885,
-0.015654858201742172,
-0.04274662584066391,
0.0008876009960658848,
0.03641379252076149,
0.0032727515790611506,
0.021928617730736732,
-0.042722996324300766,
0.039485689252614975,
0.006586855743080378,
0.04678735136985779,
-0.008843518793582916,
-0.013717200607061386,
0.019967330619692802,
0.0005150596261955798,
-0.007614759728312492,
-0.018903980031609535,
-0.014048020355403423,
0.07202416658401489,
0.04274662584066391,
0.004702365025877953,
-0.018348677083849907,
0.0035149590112268925,
0.01330367662012577,
0.010214056819677353,
0.02368905022740364,
0.013398196548223495,
0.021385127678513527,
0.023098301142454147,
0.001949473051354289,
0.0038575935177505016,
0.02495325542986393,
0.01879764534533024,
0.020179999992251396,
-0.003978697117418051,
0.024362504482269287,
0.033909015357494354,
0.021385127678513527,
0.0007775739068165421,
-0.017214437946677208,
-0.013339121825993061,
-0.04622023180127144,
0.03698091208934784,
-0.0042593032121658325,
-0.0354449637234211,
0.006610485725104809,
-0.0067640808410942554,
-0.007331199944019318,
-0.02951383963227272,
0.032089509069919586,
0.05496332421898842,
0.048630490899086,
0.017651591449975967,
0.01421343069523573,
0.004661012906581163,
-0.024220725521445274,
-0.013469086028635502,
0.021172458305954933,
-0.022507552057504654,
0.05137156695127487,
-0.03459428623318672,
-0.03449976444244385,
0.02483510412275791,
-0.012145807966589928,
-0.013055562041699886,
0.01563122868537903,
0.04577126353979111,
0.025284074246883392,
0.008040099404752254,
-0.05628660321235657,
0.032278548926115036,
0.015335854142904282,
-0.0006210253341123462,
0.026867283508181572,
0.013256416656076908,
0.006976750213652849,
0.000907538749743253,
0.03310559689998627,
-0.04586578160524368,
0.0053108371794223785,
0.015914788469672203,
0.02424435503780842,
0.017119918018579483,
-0.004968202672898769,
0.013516345992684364,
-0.023700866848230362,
0.02894672006368637,
-0.004504464101046324,
-0.0029138713143765926,
-0.020558079704642296,
0.042912036180496216,
0.05387634411454201,
0.017320772632956505,
-0.010538969188928604,
-0.011513705365359783,
0.009717827662825584,
-0.030553558841347694,
-0.03553948551416397,
-0.06994473189115524,
0.019081205129623413,
0.03057718835771084,
-0.008246861398220062,
-0.040194589644670486,
0.03308196738362312,
0.02198769338428974,
-0.038918569684028625,
0.004418805707246065,
0.05080444738268852,
0.0007103761308826506,
0.0420377254486084,
-0.011631855741143227,
0.011171070858836174,
0.0013218017993494868,
0.008418179117143154,
0.011295128613710403,
0.027528921142220497,
-0.04137608781456947,
-0.013008302077651024,
-0.024362504482269287,
-0.03487784415483475,
0.013138266280293465,
-0.018856720998883247,
-0.016198348253965378,
0.009735549800097942,
0.027812480926513672,
0.013764460571110249,
0.0003463268221821636,
0.02729262225329876,
-0.0028518426697701216,
0.012689297087490559,
0.019423840567469597,
0.02274385280907154,
-0.00231130700558424,
0.0016688670730218291,
0.013280046172440052,
-0.023015595972537994,
0.02774159237742424,
-0.004194320645183325,
0.022684777155518532,
0.004014142323285341,
0.00514542730525136,
-0.03161690756678581,
-0.0010832867119461298,
-0.015583968721330166,
0.03286929801106453,
-0.029348429292440414,
0.015560339204967022,
-0.008542235940694809,
-0.022968336939811707,
0.01817145198583603,
0.004501510411500931,
0.04196683689951897,
0.044944215565919876,
-0.005275391973555088,
0.017013583332300186,
0.010716194286942482,
0.014815994538366795,
0.006970842834562063,
0.019908254966139793,
0.017001768574118614,
-0.008335473947227001,
-0.010279039852321148,
0.02064078487455845,
0.006173331290483475,
-0.019683770835399628,
-0.016635503619909286,
-0.02032177895307541,
0.005789344199001789,
0.04799248278141022,
0.032065875828266144,
-0.02793063223361969,
0.015264964662492275,
-0.006610485725104809,
-0.0017648638458922505,
0.015064110048115253,
0.011218330822885036,
-0.01837230660021305,
-0.010042740032076836,
0.015914788469672203,
-0.005071583669632673,
-0.016883617267012596,
0.0295847300440073,
0.022342141717672348,
0.020947974175214767,
0.005854326765984297,
0.001785540021955967,
0.002408780623227358,
-0.015312224626541138,
-0.02989191934466362,
0.0028075366280972958,
-0.02331097051501274,
0.007496609818190336,
-0.004285886883735657,
-0.008784443140029907,
0.01085797417908907,
-0.02064078487455845,
-0.00012331893958617002,
-0.03060081973671913,
0.009747365489602089,
0.02165687270462513,
-0.016623688861727715,
-0.046763721853494644,
0.00848906859755516,
-0.028545010834932327,
-0.006232406012713909,
-0.033412784337997437,
0.03331826627254486,
-0.006870415527373552,
-0.03253847733139992,
-0.022519366815686226,
0.031073417514562607,
-0.013031931594014168,
0.03305833786725998,
0.03648468106985092,
-0.018159637227654457,
0.011324666440486908,
0.010214056819677353,
0.017249882221221924,
-0.03705180063843727,
-0.006876322906464338,
0.009404730051755905,
-0.027009062469005585,
-0.031309716403484344,
0.0020809147972613573,
0.02691454254090786,
-0.01589115895330906,
-0.0014177985722199082,
-0.02710358239710331,
-0.0008034191560000181,
-0.03133334964513779,
0.007331199944019318,
0.006120163947343826,
0.021066123619675636,
0.027883371338248253,
-0.0149814048781991,
-0.004321332089602947,
0.007278032600879669,
-0.01089341938495636,
-0.013539976440370083,
0.008164157159626484,
0.0299628097563982,
-0.011797265149652958,
0.025496743619441986,
-0.00039358678623102605,
-0.00997775699943304,
-0.021704133599996567,
-0.02785974182188511,
-0.018384121358394623,
0.051844168454408646,
-0.03984013944864273,
-0.02088889852166176,
0.03478332608938217,
-0.011962675489485264,
-0.019742844626307487,
0.015619413927197456,
0.008808073587715626,
0.0030718969646841288,
0.005942938849329948,
-0.029797399416565895,
0.02660735324025154,
0.05033184960484505,
-0.00465805921703577,
0.0027898140251636505,
0.040312737226486206,
0.014768734574317932,
0.0042593032121658325,
-0.001965718576684594,
0.0021458971314132214,
0.01137192640453577,
-0.02039266936480999,
-0.0075084250420331955,
-0.007656112313270569,
0.010911141522228718,
0.005945892538875341,
0.04028910771012306,
-0.002305399626493454,
-0.01472147461026907,
0.013374566100537777,
0.019908254966139793,
-0.027788851410150528,
0.0024959163274616003,
-0.00745525723323226,
-0.008193694055080414,
-0.02223580703139305,
-0.025496743619441986,
-0.01443791575729847,
-0.019152095541357994,
-0.018029671162366867,
-0.0009267381392419338,
-0.016056569293141365,
0.013469086028635502,
0.0003679261135403067,
-0.036508314311504364,
-0.0016024077776819468,
-0.0011682069161906838,
0.0014968112809583545,
-0.007927857339382172,
0.0009717827779240906,
-0.028450490906834602,
-0.024433394894003868,
0.021609613671898842,
-0.007390275131911039,
0.01664731837809086,
0.015678489580750465,
-0.016304682940244675,
0.018478641286492348,
0.02514229528605938,
-0.009859607554972172,
-0.00036681845085695386,
0.001720557571388781,
-0.04418805614113808,
0.014367025345563889,
-0.011767728254199028,
-0.008684015832841396,
-0.010403096675872803,
-0.019671954214572906,
-0.03161690756678581,
0.008181879296898842,
-0.004445389378815889,
0.021255163475871086,
-0.018407750874757767,
0.02419709600508213,
-0.00032768130768090487,
0.0009415068780072033,
0.00035574191133491695,
0.006923582870513201,
-0.05945301800966263,
0.0066813756711781025,
-0.007307569961994886,
-0.006120163947343826,
0.04199046641588211,
-0.032396696507930756,
-0.012275772169232368,
0.016422832384705544,
-0.011247868649661541,
0.03388538584113121,
-0.0012051287340000272,
0.011342388577759266,
-0.0025815749540925026,
-0.009062095545232296,
0.025307703763246536,
0.030931638553738594,
0.004560585133731365,
-0.023334601894021034,
0.0013675849186256528,
-0.027198102325201035,
-0.004155922215431929,
0.038989461958408356,
0.02279111184179783,
0.021361498162150383,
-0.01863223686814308,
-0.02646557241678238,
-0.02196406200528145,
-0.0009016312542371452,
-0.03501962497830391,
-0.02324008196592331,
0.011631855741143227,
0.005293114576488733,
-0.016162903979420662,
-0.004229765851050615,
-0.016375573351979256,
0.04697639122605324,
0.0026258809957653284,
0.027599811553955078,
0.0004869990225415677,
0.0010463648941367865,
-0.025662153959274292,
-0.030884379521012306,
-0.007585222367197275,
0.021054308861494064,
0.001221374375745654,
0.00031882006442174315,
0.046007562428712845,
-0.02793063223361969,
0.036697354167699814,
0.0066754682920873165,
0.013658125884830952,
-0.010409004054963589,
-0.04180142655968666,
0.02190498821437359,
-0.006297388579696417,
-0.02158598229289055,
0.0028429816011339426,
0.014686030335724354,
-0.0001334724365733564,
-0.032467588782310486,
0.042084988206624985,
-0.018147822469472885,
-0.011879970319569111,
0.009676475077867508,
-0.013327306136488914,
-0.010816621594130993,
-0.012334847822785378,
0.022531181573867798,
0.0031132493168115616,
-0.023665420711040497,
-0.018407750874757767,
0.010237687267363071,
-0.001984918024390936,
-0.005606211721897125,
0.01162594836205244,
-0.010048647411167622,
-0.016422832384705544,
-0.014839624986052513,
-0.04362093657255173,
-0.04995376989245415,
0.017876077443361282,
0.01882127672433853,
-0.015418559312820435,
0.01665913313627243,
-0.001756002544425428,
0.007171697914600372,
0.008890778757631779,
-0.02488236501812935,
-0.006214683875441551,
0.022117657586932182,
0.015111370012164116,
0.000891293166205287,
0.017320772632956505,
0.025992972776293755,
0.024409765377640724,
-0.025165924802422523,
-0.008494975976645947,
-0.04021821916103363,
-0.0026096354704350233,
0.028521381318569183,
-0.024078944697976112,
0.011442815884947777,
0.042084988206624985,
-0.01626923866569996,
0.0054083107970654964,
-0.0028429816011339426,
-0.002221217844635248,
0.06526599079370499,
-0.01875038631260395,
-0.007573407143354416,
-0.031002528965473175,
-0.007443442475050688,
-0.0505208894610405,
0.019589250907301903,
0.024622434750199318,
-0.014815994538366795,
0.005491015501320362,
0.018974870443344116,
0.03045903891324997,
-0.038658641278743744,
-0.024787845090031624,
-0.020038219168782234,
0.03268025815486908,
-0.0036390163004398346,
0.007650204934179783,
0.00193913490511477,
0.010846159420907497,
-0.032065875828266144,
0.0005973953520879149,
-0.010852066799998283,
-0.025425855070352554,
0.017521627247333527,
-0.006628208328038454,
0.030506299808621407,
0.00432428577914834,
-0.006663653068244457,
0.005916355177760124,
-0.0074257198721170425,
-0.001259773038327694,
-0.03234943747520447,
-0.015241334214806557,
-0.03133334964513779,
-0.010302669368684292,
-0.02521318383514881,
-0.016068384051322937,
-0.014225245453417301,
0.00405549444258213,
0.04418805614113808,
-0.005774575285613537,
-0.007975117303431034,
0.013055562041699886,
-0.011679115705192089,
-0.017131732776761055,
0.010822528973221779,
-0.042392175644636154,
0.008016468957066536,
-0.007118530105799437,
-0.022212177515029907,
-0.025662153959274292,
-0.0062678512185812,
-0.005387634504586458,
0.003432254074141383,
-0.05415990576148033,
-0.006758172996342182,
0.007656112313270569,
-0.02286200225353241,
0.007939672097563744,
0.039745621383190155,
0.005183826200664043,
-0.005204502027481794,
-0.0440935343503952,
-0.0013284477172419429,
-0.008223231881856918,
-0.0015905927866697311,
-0.025685783475637436,
-0.01044444926083088,
-0.012736557051539421,
-0.005440801847726107,
-0.023712681606411934,
-0.020617153495550156,
-0.032514847815036774,
0.0012354046339169145,
-0.026938172057271004,
-0.009670567698776722,
-0.0026657567359507084,
-0.005798205267637968,
0.013823536224663258,
0.010273132473230362,
-0.046007562428712845,
-0.0002591912925709039,
-0.0025446531362831593,
0.013055562041699886,
0.01690724864602089,
0.04692913219332695,
-0.001518225995823741,
0.003916668705642223,
0.015690304338932037,
0.019742844626307487,
-0.002154758432880044,
0.013433641754090786,
0.027788851410150528,
-0.017651591449975967,
-0.021373312920331955,
-0.016186533495783806,
0.002171003958210349,
-0.015383114106953144,
-0.014922330155968666,
-0.01099384669214487,
-0.007100807968527079,
0.022448476403951645,
-0.038800422102212906,
0.011637763120234013,
-0.0001385491923429072,
0.019541990011930466,
0.004339054226875305,
0.043148335069417953,
-0.02887583151459694,
0.05864959955215454,
-0.009387007914483547,
-0.010491709224879742,
0.0051040747202932835,
-0.032703887671232224,
-0.03374360501766205,
0.01047989446669817,
0.010279039852321148,
0.004454250447452068,
0.017509812489151955,
0.02361816167831421,
0.016422832384705544,
0.010538969188928604,
-0.010745731182396412,
0.009989572688937187,
0.014993219636380672,
-0.004188413266092539,
-0.00529016088694334,
0.03008095920085907,
-0.006409631110727787,
-0.0028902413323521614,
0.023275526240468025,
0.02001458965241909,
-0.03244395554065704,
-0.003039405681192875,
-0.035870302468538284,
-0.0045458166860044,
-0.029750140383839607,
-0.005866141524165869,
0.11484168469905853,
-0.003063035663217306,
-0.01257114764302969,
0.016635503619909286,
-0.002955223899334669,
-0.024811474606394768,
0.0017781556816771626,
-0.0037748885806649923,
-0.0032136766240000725,
-0.013362751342356205,
0.017190808430314064,
0.00020214705727994442,
0.02660735324025154,
-0.0024471792858093977,
0.008376826532185078,
-0.011448723264038563,
-0.005027277395129204,
0.04352641478180885,
0.002971469424664974,
-0.01387079618871212,
-0.013504531234502792,
0.010403096675872803,
-0.0117795430123806,
0.01824234053492546,
-0.016233794391155243,
0.01364631112664938,
-0.011135626584291458,
-0.02236577309668064,
-0.034168943762779236,
0.00991277489811182,
0.04307744652032852,
0.021692318841814995,
0.02660735324025154,
-0.0059281704016029835,
0.015300409868359566,
-0.02552037499845028,
-0.015430374071002007,
-0.022708406671881676,
0.013244601897895336,
-0.0014273981796577573,
0.0008455101051367819,
-0.0026406499091535807,
-0.012913782149553299,
0.01044444926083088,
0.03426346555352211,
0.008536328561604023,
-0.028521381318569183,
0.01651735231280327,
0.0295847300440073,
-0.030506299808621407,
-0.008400456048548222,
-0.009008928202092648,
0.041068896651268005,
-0.019329320639371872,
-0.03998192027211189,
0.00428884057328105,
0.03197135776281357,
0.002893195254728198,
0.0007232988136820495,
-0.040879856795072556,
-0.023381860926747322,
0.007413905113935471,
0.01873857155442238,
0.0011563919251784682,
0.009830069728195667
] | 2024-07-19 | 1 | 39028827 | [
"CAR T cells",
"T cell function",
"T cell lymphomas",
"CAR T cell activation",
"T cell therapies",
"T cell effector function",
"CAR T cell dysfunction",
"adoptive T cell immunotherapies",
"CD5 KO",
"enhanced cytotoxicity",
"CD5",
"solid cancers",
"several hematological malignancies",
"vivo expansion",
"apparent toxicity",
"expansion",
"persistence",
"preclinical models",
"multiple hematological and solid cancer models",
"Most patients",
"KO",
"CAR",
"US Food and Drug Administration",
"disease progression",
"lack",
"a potential clinical target",
"the clinical success",
"infusion",
"a critical inhibitor",
"CRISPR-Cas9"
] | [] | 0 | 10.1126/sciimmunol.adn6509 | [
"Patel",
"Ghilardi",
"Zhang",
"Chiang",
"Xie",
"Guruprasad",
"Kim",
"Chun",
"Angelos",
"Pajarillo",
"Hong",
"Lee",
"Shestova",
"Shaw",
"Cohen",
"Gupta",
"Vu",
"Qian",
"Yang",
"Nimmagadda",
"Snook",
"Siciliano",
"Rotolo",
"Inamdar",
"Harris",
"Ugwuanyi",
"Wang",
"Carturan",
"Paruzzo",
"Chen",
"Ballard",
"Blanchard",
"Xu",
"Abdel-Mohsen",
"Gabunia",
"Wysocka",
"Linette",
"Carreno",
"Barrett",
"Teachey",
"Posey",
"Powell",
"Sauter",
"Pileri",
"Pillai",
"Scholler",
"Rook",
"Schuster",
"Barta",
"Porazzi",
"Ruella"
] | [
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, MacKay Memorial Hospital, Taipei, Taiwan.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.\nCollege of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Republic of Korea.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"viTToria Biotherapeutics, Philadelphia, PA, USA.",
"viTToria Biotherapeutics, Philadelphia, PA, USA.",
"viTToria Biotherapeutics, Philadelphia, PA, USA.",
"viTToria Biotherapeutics, Philadelphia, PA, USA.",
"viTToria Biotherapeutics, Philadelphia, PA, USA.",
"viTToria Biotherapeutics, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Pathology and Laboratory Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Pathology and Laboratory Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Division of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Dermatology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Oncology, Children's Hospital of Philadelphia, PA, USA.",
"Division of Oncology, Children's Hospital of Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Division of Haematopathology, Istituto Europeo di Oncologia IRCCS, Italy.",
"Division of Hemato-pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Dermatology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.\nDivision of Hematology and Oncology, Hospital of University of Pennsylvania, Philadelphia, PA, USA.\nLymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA."
] | [
"39028827"
] | [] | 8.473936 | 5.167303 |
39026380 | 712 | CAR-T cell combination therapies in hematologic malignancies. | Chimeric antigen receptor-T cell therapy, a groundbreaking cancer treatment, has achieved remarkable success against hematologic malignancies. However, CAR-T monotherapy faces challenges in certain cases, including treatment tolerance and relapse rates. To overcome these challenges, researchers are investigating combining CAR-T cells with other treatments to enhance therapeutic efficacy. Therefore, this review aims to investigate the progress of research in combining CAR-T cells for hematologic malignancies. It covers the basic principles and clinical applications of CAR-T cell therapy, detailing combinations with chemotherapy, immune checkpoint inhibitors, targeted drugs, radiotherapy, hematopoietic stem cell transplantation, and other treatments. These combinations synergistically enhance the antitumor effects of CAR-T cells and comprehensively target tumors through different mechanisms, improving patient response and survival rates. | [
0.01885387673974037,
0.013705027289688587,
0.07822790741920471,
0.051055822521448135,
-0.04151530563831329,
-0.02838357724249363,
0.01748012937605381,
0.04419790208339691,
0.02142830193042755,
0.005046089179813862,
-0.018291397020220757,
-0.026804307475686073,
-0.05529605224728584,
0.006571273785084486,
-0.002377016469836235,
-0.02715044841170311,
0.026479799300432205,
0.005700512323528528,
0.05131543055176735,
0.03504679352045059,
-0.0008640008163638413,
0.013575224205851555,
0.021796077489852905,
0.01429995708167553,
-0.04372195899486542,
-0.011022432707250118,
-0.006468513049185276,
0.03695056959986687,
-0.05088275298476219,
-0.02764802612364292,
0.0029232704546302557,
-0.021439118310809135,
-0.01851855218410492,
-0.014321590773761272,
0.0028718900866806507,
0.04577717185020447,
0.022499175742268562,
0.035133328288793564,
-0.009459389373660088,
-0.005657244939357042,
0.054257627576589584,
0.06217560917139053,
0.044068098068237305,
0.0996021255850792,
-0.06797347217798233,
-0.012006771750748158,
0.0011344236554577947,
-0.045084889978170395,
-0.019935568794608116,
0.00908079743385315,
-0.027193715795874596,
0.008247895166277885,
-0.03487372398376465,
0.025333207100629807,
-0.04902224242687225,
0.032645437866449356,
-0.03219113126397133,
0.005976343527436256,
0.007642148062586784,
-0.006906598340719938,
-0.010508629493415356,
0.0055193291045725346,
0.007485303096473217,
-0.01660395972430706,
-0.06498800218105316,
0.010649249888956547,
-0.035630907863378525,
-0.051877908408641815,
-0.011049475520849228,
0.00711752800270915,
0.022758781909942627,
-0.008166768588125706,
-0.006230541039258242,
0.014473027549684048,
0.029357098042964935,
0.006392794661223888,
-0.004315947648137808,
0.04227248951792717,
0.019708413630723953,
-0.016452522948384285,
0.025527911260724068,
-0.015630437061190605,
0.018010158091783524,
-0.04039034992456436,
-0.009962375275790691,
-0.012612518854439259,
-0.002725861733779311,
-0.03467901796102524,
-0.04945491999387741,
-0.01948125846683979,
-0.016225367784500122,
0.013445421122014523,
-0.03803226351737976,
0.04517142474651337,
-0.002931383205577731,
-0.0060358368791639805,
-0.0058519490994513035,
-0.06018529832363129,
0.011487560346722603,
0.036864034831523895,
0.03742651641368866,
0.020995626226067543,
-0.03803226351737976,
-0.0006358316168189049,
0.054041292518377304,
0.0038670459762215614,
-0.06265155225992203,
-0.02857828140258789,
0.02260734513401985,
-0.020032919943332672,
0.04897897690534592,
-0.028859520331025124,
0.0006828175392001867,
0.050623148679733276,
-0.02301838807761669,
-0.05655081570148468,
-0.020779287442564964,
-0.010541080497205257,
-0.014581196941435337,
0.03216949477791786,
-0.021904246881604195,
0.017490945756435394,
0.027323519811034203,
-0.017415227368474007,
0.004345694091171026,
-0.025138502940535545,
0.0968329906463623,
-0.02128768153488636,
-0.025333207100629807,
-0.055901799350976944,
0.03415980562567711,
0.025246672332286835,
0.012915392406284809,
-0.02827540785074234,
-0.047161735594272614,
-0.0022161148954182863,
-0.032840143889188766,
0.0039049051702022552,
-0.03374876454472542,
-0.02559281326830387,
0.00438355328515172,
-0.03353242576122284,
-0.014159337617456913,
0.009183557704091072,
-0.021439118310809135,
-0.05659408122301102,
0.008950994350016117,
0.03104453720152378,
-0.009621643461287022,
0.01794525608420372,
-0.03701547160744667,
0.03580397740006447,
0.03794572502374649,
0.005232681054621935,
-0.004004961811006069,
-0.030049381777644157,
-0.017382776364684105,
0.0633438378572464,
-0.0322127640247345,
-0.0545172356069088,
-0.006928232032805681,
-0.003007101360708475,
-0.012158208526670933,
-0.025268305093050003,
0.002985467668622732,
-0.04608004540205002,
-0.023277994245290756,
0.028405210003256798,
-0.042640265077352524,
-0.0036777500063180923,
-0.01983821578323841,
-0.062478482723236084,
-0.06602642685174942,
-0.010400461032986641,
-0.02715044841170311,
-0.0014372972073033452,
-0.002018706174567342,
0.029962845146656036,
-0.024640925228595734,
-0.008345247246325016,
0.008740064688026905,
0.025765884667634964,
0.016128014773130417,
-0.0035344259813427925,
-0.02673940546810627,
0.025549545884132385,
0.002432452980428934,
0.006106146611273289,
-0.035306401550769806,
-0.006008794531226158,
0.002106593456119299,
0.004416004288941622,
0.028729718178510666,
0.018734890967607498,
-0.012677420862019062,
-0.010903446935117245,
0.03725344315171242,
0.033986736088991165,
-0.04383012652397156,
-0.02082255482673645,
0.01898368075489998,
-0.018183229491114616,
-0.022434275597333908,
0.007804401684552431,
-0.054430700838565826,
-0.017718100920319557,
-0.00022935232846066356,
0.029378732666373253,
-0.011282038874924183,
0.016171284019947052,
0.031520482152700424,
0.01321826595813036,
-0.012796406634151936,
0.03268870711326599,
-0.04370032250881195,
-0.03904905170202255,
-0.024035178124904633,
0.02282368391752243,
0.0024027065373957157,
0.03930865600705147,
-0.0021336358040571213,
-0.004800004418939352,
-0.0047837793827056885,
0.011044067330658436,
-0.009583784267306328,
-0.0058303154073655605,
0.0069985417649149895,
-0.031325776129961014,
0.0003586482198443264,
-0.022542444989085197,
0.009091614745557308,
-0.0028935240115970373,
0.03314301744103432,
-0.009107839316129684,
-0.026912476867437363,
-0.03636645898222923,
0.015132859349250793,
0.0035668767523020506,
0.039957672357559204,
-0.004467384424060583,
0.02652306854724884,
0.036041948944330215,
0.05408455803990364,
-0.027085546404123306,
-0.01015167124569416,
-0.00680924579501152,
-0.018291397020220757,
-0.06468513607978821,
0.018951229751110077,
-0.007133753504604101,
0.006176456809043884,
0.036236654967069626,
-0.025008700788021088,
0.026999011635780334,
0.04359215497970581,
-0.007798993494361639,
0.058238252997398376,
-0.04233739152550697,
0.009345811791718006,
-0.01470018271356821,
-0.012158208526670933,
0.010108403861522675,
-0.04945491999387741,
-0.049411654472351074,
-0.0721704363822937,
0.02589568682014942,
-0.0009606769890524447,
0.017436861991882324,
0.040887925773859024,
-0.008534543216228485,
0.017242157831788063,
0.035025160759687424,
0.05880073085427284,
-0.03024408593773842,
-0.04703193157911301,
-0.00538411783054471,
0.009134882129728794,
0.03852983936667442,
0.03074166364967823,
0.0249005313962698,
0.020887456834316254,
0.0027664252556860447,
0.010124629363417625,
-0.029876310378313065,
-0.004432229790836573,
-0.03260217234492302,
0.006706485524773598,
-0.0053056953474879265,
0.008356064558029175,
-0.02323472686111927,
0.0074149928987026215,
0.0008545360178686678,
-0.00621972419321537,
-0.024597657844424248,
-0.009994826279580593,
0.005376005079597235,
-0.015057140961289406,
-0.0015008464688435197,
-0.013099280185997486,
0.017436861991882324,
-0.04897897690534592,
0.023689037188887596,
-0.009037530049681664,
-0.03537129983305931,
0.05854112654924393,
0.017490945756435394,
-0.028751350939273834,
-0.034094907343387604,
0.021493203938007355,
0.03372713178396225,
0.036647696048021317,
-0.047854017466306686,
0.03556600585579872,
0.01887551136314869,
0.006133188959211111,
0.01564125530421734,
0.026047123596072197,
-0.04845976456999779,
0.004843272268772125,
-0.039633166044950485,
-0.0052272723987698555,
-0.008983445353806019,
-0.003337017260491848,
0.026349997147917747,
0.013477872125804424,
-0.04707520082592964,
0.017653200775384903,
-0.040044207125902176,
0.0410393625497818,
-0.032342568039894104,
-0.021244414150714874,
-0.05265672504901886,
0.057329632341861725,
-0.023732304573059082,
0.015511451289057732,
0.005684287287294865,
-0.033575695008039474,
-0.047248270362615585,
0.021709542721509933,
0.018540186807513237,
-0.009351219981908798,
0.024727459996938705,
-0.03766448795795441,
0.05109909176826477,
-0.002724509686231613,
-0.038097161799669266,
-0.0010019164765253663,
0.02838357724249363,
-0.009188966825604439,
0.03762121871113777,
0.018377933651208878,
0.01176880020648241,
0.02416498027741909,
-0.0017618044512346387,
-0.009897474199533463,
0.05996895954012871,
-0.04893570765852928,
-0.0034965667873620987,
0.018648356199264526,
-0.009762262925505638,
0.035414569079875946,
-0.003967102617025375,
-0.06831961125135422,
0.04625311493873596,
0.05430089682340622,
0.0710887461900711,
-0.017415227368474007,
0.04060668498277664,
-0.05304613709449768,
-0.04112589731812477,
-0.029854675754904747,
-0.020011287182569504,
0.013791562058031559,
0.029378732666373253,
-0.031931523233652115,
0.037275079637765884,
0.044392604380846024,
0.0008545360178686678,
-0.00006823950388934463,
0.024013543501496315,
0.020703569054603577,
-0.02890278771519661,
-0.014775901101529598,
-0.018237313255667686,
-0.03149884566664696,
0.023213092237710953,
0.02682594209909439,
-0.013975449837744236,
-0.06940130889415741,
0.027410054579377174,
-0.017934439703822136,
-0.02827540785074234,
0.017609931528568268,
0.010654658079147339,
-0.013780745677649975,
0.08644875884056091,
-0.03870290890336037,
0.09432347118854523,
0.03489535674452782,
-0.007550204638391733,
-0.0014643394388258457,
-0.04145040735602379,
-0.00950806587934494,
-0.03186662122607231,
0.026609603315591812,
-0.020595399662852287,
0.014418943785130978,
0.005148849915713072,
0.03885434567928314,
-0.012428632006049156,
-0.004602596163749695,
0.018269764259457588,
0.02983304299414158,
0.017242157831788063,
0.015435732901096344,
-0.02366740256547928,
-0.05637774243950844,
0.055252786725759506,
-0.018918778747320175,
0.022369373589754105,
0.0481136217713356,
-0.010227389633655548,
0.0272586178034544,
-0.01224474422633648,
0.0023161713033914566,
0.00023205655452329665,
0.03980623558163643,
0.014321590773761272,
0.004848680924624205,
-0.035003527998924255,
-0.044695477932691574,
0.05884400010108948,
0.027539856731891632,
-0.0108493622392416,
-0.01015167124569416,
0.04763767868280411,
-0.028340307995676994,
0.028816252946853638,
-0.03292667865753174,
0.008615669794380665,
-0.04798382148146629,
-0.009037530049681664,
0.029248928651213646,
-0.03251563757658005,
0.029075859114527702,
-0.009432347491383553,
0.010351784527301788,
0.03837840259075165,
-0.037902459502220154,
-0.015900859609246254,
-0.006587499286979437,
-0.015803508460521698,
0.009416121989488602,
0.014289140701293945,
-0.03811879828572273,
-0.009578375145792961,
0.006089921109378338,
-0.05447396636009216,
0.009210600517690182,
0.016149649396538734,
0.022780416533350945,
-0.023797206580638885,
0.023061655461788177,
-0.04884917289018631,
0.007766542490571737,
0.044998351484537125,
0.053522080183029175,
-0.008053191006183624,
0.0028096928726881742,
-0.0398278683423996,
0.03602031618356705,
-0.0051191034726798534,
-0.012050040066242218,
-0.024943798780441284,
-0.017188072204589844,
0.03803226351737976,
0.024229882284998894,
0.02325635962188244,
0.01862672157585621,
-0.0005175216356292367,
-0.03379203379154205,
-0.025268305093050003,
-0.02214221842586994,
0.003420848399400711,
0.013878097757697105,
0.00801533181220293,
-0.014537929557263851,
-0.0016374100232496858,
-0.016430888324975967,
0.042207591235637665,
-0.007663782220333815,
-0.0013298040721565485,
-0.00020011287415400147,
-0.007306823972612619,
-0.017501763999462128,
-0.005505808163434267,
0.0009965080535039306,
-0.014105252921581268,
-0.019924750551581383,
0.013510323129594326,
-0.008642712607979774,
0.005987160839140415,
0.005559892859309912,
0.025030333548784256,
0.04543102905154228,
0.06252174824476242,
0.016560692340135574,
0.051877908408641815,
0.006160231307148933,
0.03433287888765335,
-0.03954663127660751,
-0.02446785382926464,
0.059276677668094635,
0.002124171005561948,
-0.05533932149410248,
-0.029941212385892868,
-0.07818464189767838,
-0.022066500037908554,
0.0164417065680027,
-0.0015211282297968864,
-0.01512204296886921,
-0.00009811276686377823,
-0.004015778657048941,
0.013575224205851555,
0.034700654447078705,
-0.030698396265506744,
-0.02323472686111927,
0.00544631527736783,
-0.02723698318004608,
-0.02673940546810627,
0.0013690154301002622,
0.000047028213884914294,
-0.030720029026269913,
0.015035507269203663,
-0.020433146506547928,
-0.013477872125804424,
-0.047767482697963715,
0.037902459502220154,
-0.026285095140337944,
-0.05057987943291664,
-0.001252057496458292,
-0.011076517403125763,
0.022650612518191338,
-0.005535554606467485,
0.007923387922346592,
0.012093307450413704,
0.0024594953283667564,
-0.03783755749464035,
0.011022432707250118,
-0.0011209024814888835,
0.010898038744926453,
-0.04915204644203186,
0.016365988180041313,
0.0004451835120562464,
0.029270563274621964,
-0.02764802612364292,
-0.021211963146924973,
-0.04060668498277664,
-0.02589568682014942,
-0.024294784292578697,
-0.018897144123911858,
-0.028448477387428284,
-0.003112566424533725,
-0.018940413370728493,
-0.029140761122107506,
0.05278652906417847,
-0.00005108455661684275,
-0.022044865414500237,
-0.02673940546810627,
0.020335793495178223,
0.009307952597737312,
-0.007701640948653221,
0.015511451289057732,
-0.036539528518915176,
0.035414569079875946,
0.008199218660593033,
-0.006960682570934296,
0.019189201295375824,
-0.016073931008577347,
0.029854675754904747,
-0.024640925228595734,
-0.028772985562682152,
-0.018367115408182144,
0.06676197797060013,
-0.017004184424877167,
0.017599115148186684,
-0.03294831141829491,
-0.003074707230553031,
0.0037778064142912626,
0.015284296125173569,
0.048892442137002945,
0.020887456834316254,
0.04054178670048714,
0.011887785978615284,
-0.03190989047288895,
0.027842730283737183,
0.0028962281066924334,
-0.013510323129594326,
0.005159666761755943,
0.0026514953933656216,
-0.004164510872215033,
-0.007577246520668268,
-0.004713469184935093,
-0.0481136217713356,
-0.045820437371730804,
0.012731505557894707,
0.01813996024429798,
-0.0054354979656636715,
0.006106146611273289,
0.0056410194374620914,
0.049627989530563354,
0.010930489748716354,
-0.03303484991192818,
0.01361849159002304,
0.024943798780441284,
0.0345708504319191,
-0.024294784292578697,
0.004375440999865532,
0.0068741473369300365,
-0.016420071944594383,
-0.0033099749125540257,
-0.0001007324899546802,
-0.02805906906723976,
-0.028340307995676994,
-0.003009805688634515,
-0.05070968344807625,
-0.018432017415761948,
-0.0013047900283709168,
0.011346940882503986,
0.013997083529829979,
-0.00112698704469949,
-0.027280250564217567,
-0.021060526371002197,
0.016528241336345673,
-0.00860485341399908,
-0.035630907863378525,
0.04151530563831329,
-0.026999011635780334,
0.008231669664382935,
0.01923246867954731,
-0.019719230011105537,
-0.0035560596734285355,
-0.01464609894901514,
0.004856793209910393,
0.01803179271519184,
-0.020173540338873863,
-0.01835629902780056,
0.00573296332731843,
-0.00010707052570069209,
-0.012006771750748158,
0.008199218660593033,
-0.010925080627202988,
0.027280250564217567,
-0.023061655461788177,
-0.007041809614747763,
-0.014451393857598305,
0.005776230711489916,
-0.0017753256252035499,
0.05797864869236946,
0.07757889479398727,
-0.018150778487324715,
0.015543902292847633,
0.0011560574639588594,
-0.00866975449025631,
-0.00858862791210413,
0.010838545858860016,
0.018280580639839172,
-0.012861307710409164,
0.0072905984707176685,
0.005960118491202593,
0.0580219142138958,
0.023624135181307793,
-0.002124171005561948,
-0.008967219851911068,
-0.004778370726853609,
0.02323472686111927,
0.010297699831426144,
-0.013023561798036098,
-0.01413770392537117,
0.019903117790818214,
-0.022564077749848366,
0.017664017155766487,
-0.03359732776880264,
-0.0545172356069088,
-0.011000799015164375,
-0.015230211429297924,
0.008485867641866207,
0.01685274764895439,
0.005635611247271299,
-0.01769646815955639,
0.010811503045260906,
-0.02046559751033783,
-0.03180171921849251,
-0.015251846052706242,
0.013780745677649975,
0.031239241361618042,
-0.0015251846052706242,
-0.019383905455470085,
0.002646086970344186,
-0.020671118050813675,
0.03208296000957489,
0.02684757485985756,
0.03299158066511154,
-0.03835676982998848,
0.018886327743530273,
-0.009378262795507908,
0.02827540785074234,
0.00028259181999601424,
-0.0002286762755829841,
0.018561821430921555,
0.007160795386880636,
-0.00128586043138057,
-0.010860179550945759,
-0.013510323129594326,
0.0034505948424339294,
0.008664346300065517,
-0.01865917257964611,
0.03329445421695709,
-0.009984009899199009,
0.015046324580907822,
0.010714150965213776,
0.02293185330927372,
-0.0041807363741099834,
-0.0028178056236356497,
0.007128344848752022,
0.03147721290588379,
-0.052180781960487366,
0.050969287753105164,
-0.02394864335656166,
0.004421412479132414,
0.009426938369870186,
-0.04192635044455528,
-0.027518223971128464,
-0.008648120798170567,
-0.0099569670855999,
0.036755867302417755,
-0.006922823376953602,
-0.02366740256547928,
0.006127780303359032,
-0.0003525637148413807,
0.035133328288793564,
-0.032840143889188766,
-0.02334289625287056,
-0.001652283244766295,
-0.010724968276917934,
0.023624135181307793,
0.0199463851749897,
0.008848234079778194,
-0.010102995671331882,
-0.03827023506164551,
-0.0013304800959303975,
0.005662653129547834,
-0.006187273655086756,
-0.021352583542466164,
0.0009978601010516286,
-0.030373888090252876,
-0.008150543086230755,
-0.0036425951402634382,
-0.03742651641368866,
-0.02262897975742817,
-0.027323519811034203,
0.011509194038808346,
-0.009064571931958199,
0.00948102306574583,
0.00047154974890872836,
0.0005689019453711808,
0.03413817286491394,
0.0380755290389061,
-0.020855005830526352,
0.00197949493303895,
-0.02323472686111927,
-0.024446221068501472,
0.012915392406284809,
-0.02487889677286148,
-0.02252081036567688,
0.03515496477484703,
-0.010449136607348919,
0.03292667865753174,
0.0058249072171747684,
0.008475050330162048,
-0.0018037200206890702,
-0.004113130737096071,
-0.012818040326237679,
0.031823355704545975,
0.008734656497836113,
0.00005792963202111423,
-0.010530263185501099,
0.02178526110947132,
-0.024143347516655922,
-0.009048346430063248,
-0.028816252946853638,
0.022261204198002815,
-0.023213092237710953,
0.02386210672557354,
-0.005248906556516886,
0.03411654010415077,
0.037469781935214996,
-0.06481493264436722,
0.0016144240507856011,
-0.011995955370366573,
-0.024619290605187416,
-0.0007551556336693466,
0.006062879227101803,
-0.041818179190158844,
0.006836288142949343,
0.008226261474192142,
-0.012623336166143417,
0.00779358483850956,
-0.022542444989085197,
0.005689695477485657,
0.01552226860076189,
-0.00041239475831389427,
-0.0071013025008141994,
-0.009789304807782173,
-0.0398927703499794,
0.0022336922120302916,
0.030157549306750298,
0.01326153427362442,
-0.012082490138709545,
-0.004123947583138943,
0.04268353432416916,
-0.02663123607635498,
0.010811503045260906,
-0.0027055800892412663,
-0.03969806432723999,
-0.04398156329989433,
-0.02572261542081833,
0.001667156582698226,
-0.0026285096537321806,
-0.019470442086458206,
0.03415980562567711,
-0.011401024647057056,
-0.02859991416335106,
0.02191506326198578,
-0.0014656916027888656,
-0.008345247246325016,
-0.00871302280575037,
-0.009280910715460777,
0.022044865414500237,
0.0302224513143301,
0.0010857474990189075,
-0.018432017415761948,
-0.023602500557899475,
-0.029854675754904747,
0.004832455422729254,
0.01733950898051262,
0.001910537015646696,
0.0023432134184986353,
-0.030482057482004166,
-0.018323848024010658,
-0.010962939821183681,
0.0015562832122668624,
-0.0053056953474879265,
-0.013045195490121841,
0.04132060334086418,
0.004524173215031624,
-0.0028232140466570854,
-0.030308986082673073,
0.0475078746676445,
0.058238252997398376,
-0.004113130737096071,
-0.009897474199533463,
-0.0170150026679039,
-0.03126087412238121,
0.011249587871134281,
-0.03472228720784187,
0.005265131592750549,
-0.01608474738895893,
0.004813525825738907,
-0.019297370687127113,
-0.0025095234159380198,
-0.0039022008422762156,
0.005662653129547834,
0.0007308176136575639,
-0.010108403861522675,
0.00180507218465209,
0.008577810600399971,
-0.025268305093050003,
-0.01234209630638361,
-0.0068687391467392445,
0.01558716967701912,
-0.010508629493415356,
-0.0037940319161862135,
-0.012201476842164993,
0.01939472369849682,
0.005895216949284077,
-0.0028421436436474323,
-0.022282838821411133,
-0.0050163427367806435,
-0.011325306259095669,
-0.003837299533188343,
-0.006084512919187546,
-0.01703663542866707,
-0.031022902578115463,
0.005997977685183287,
0.013531956821680069,
-0.023407796397805214,
0.028859520331025124,
-0.030417155474424362,
0.009902882389724255,
-0.01983821578323841,
-0.03197479248046875,
-0.005367892328649759,
0.04307294264435768,
0.008004514500498772,
0.007350091356784105,
-0.017188072204589844,
0.02918402850627899,
-0.029789775609970093,
0.04196961596608162,
-0.04495508596301079,
-0.003109862096607685,
-0.003664228832349181,
0.015457366593182087,
-0.02079010382294655,
-0.011952687054872513,
-0.024857264012098312,
0.0650312751531601,
0.022845318540930748,
-0.008231669664382935,
-0.013304801657795906,
-0.010524854995310307,
0.0022336922120302916,
-0.00948102306574583,
0.020800922065973282,
0.003282932797446847,
0.021979965269565582,
0.045084889978170395,
-0.009940741583704948,
0.021871795877814293,
0.023299628868699074,
-0.0052245683036744595,
0.04259699955582619,
0.015305929817259312,
0.031715184450149536,
0.013953816145658493,
0.026674505323171616,
-0.009718995541334152,
-0.008950994350016117,
-0.009437755681574345,
-0.014559563249349594,
0.03156374767422676,
-0.02194751426577568,
-0.04028217867016792,
0.008918543346226215,
0.010200347751379013,
-0.003491158364340663,
-0.026479799300432205,
0.03954663127660751,
0.042012885212898254,
0.054344166070222855,
0.006657809019088745,
0.024943798780441284,
0.012601702474057674,
-0.003296453971415758,
-0.029941212385892868,
0.013856464065611362,
-0.05010393634438515,
0.045387763530015945,
-0.017242157831788063,
-0.016506606712937355,
0.01203922275453806,
0.0038616375532001257,
-0.009908291511237621,
0.000417127157561481,
0.04010910913348198,
0.0278643649071455,
0.018323848024010658,
-0.03666933253407478,
0.012374547310173512,
-0.002241804962977767,
-0.026566335931420326,
0.012504350394010544,
0.008009923622012138,
0.007625923026353121,
0.024727459996938705,
0.037361614406108856,
-0.03958989679813385,
-0.003791327588260174,
0.009102431125938892,
0.03411654010415077,
0.02323472686111927,
-0.030611859634518623,
-0.019546160474419594,
-0.027539856731891632,
-0.004813525825738907,
-0.003629073966294527,
-0.027172083035111427,
-0.0539114885032177,
0.014667732641100883,
0.04194798320531845,
0.032234396785497665,
-0.023494333028793335,
-0.018583454191684723,
0.025938954204320908,
-0.03379203379154205,
-0.02487889677286148,
-0.051358696073293686,
0.022282838821411133,
0.03554437309503555,
-0.013661759905517101,
-0.02570098266005516,
0.011249587871134281,
-0.008356064558029175,
-0.045517563819885254,
-0.018042609095573425,
0.030893100425601006,
0.011487560346722603,
0.05395475775003433,
-0.03859474137425423,
0.032147862017154694,
0.002990876091644168,
0.024186614900827408,
0.003142312867566943,
0.01326153427362442,
-0.008680571801960468,
0.004737807437777519,
-0.052094247192144394,
-0.030071014538407326,
-0.001965973759070039,
-0.04238066077232361,
0.014256689697504044,
0.0012480012373998761,
0.04547429829835892,
0.016149649396538734,
0.010692517273128033,
-0.010048910975456238,
-0.015965761616826057,
0.013953816145658493,
0.009334994480013847,
0.0102760661393404,
-0.0009059163858182728,
0.015825141221284866,
-0.01846446841955185,
-0.015900859609246254,
0.017307057976722717,
-0.021731175482273102,
0.054863374680280685,
0.037058740854263306,
-0.0023229317739605904,
-0.04214268922805786,
-0.013586041517555714,
0.002779946429654956,
0.05200771242380142,
-0.02827540785074234,
0.004632342606782913,
-0.008437191136181355,
-0.026999011635780334,
0.00798828899860382,
0.048892442137002945,
0.044068098068237305,
0.026609603315591812,
0.019189201295375824,
0.010649249888956547,
0.008788741193711758,
0.010476179420948029,
0.024835629388689995,
0.007328457664698362,
0.0023891853634268045,
-0.006484738551080227,
-0.015035507269203663,
0.015652071684598923,
0.019686779007315636,
-0.0006929584196768701,
-0.027929266914725304,
0.013510323129594326,
0.009059163741767406,
0.0223044715821743,
0.01810751110315323,
-0.029616704210639,
0.03065512888133526,
-0.027388419955968857,
-0.016701310873031616,
0.013239899650216103,
0.0037318344693630934,
-0.007739500142633915,
-0.0018632130231708288,
0.001476508448831737,
0.0026677208952605724,
-0.020638667047023773,
-0.0030287352856248617,
0.018886327743530273,
0.02304002270102501,
-0.013239899650216103,
-0.025484643876552582,
-0.009756854735314846,
-0.03489535674452782,
-0.03515496477484703,
-0.020335793495178223,
-0.015468183904886246,
-0.021558105945587158,
-0.01321826595813036,
-0.0278643649071455,
0.0038102571852505207,
-0.003915722016245127,
-0.007977472618222237,
-0.018951229751110077,
-0.01638762094080448,
0.03312138468027115,
0.001583325443789363,
-0.03580397740006447,
0.022953486070036888,
0.007355500012636185,
-0.03937355801463127,
-0.05447396636009216,
0.04685886204242706,
-0.014116070233285427,
-0.05849785730242729,
0.02766966074705124,
0.01613883301615715,
-0.005559892859309912,
0.01156327873468399,
0.00846423301845789,
-0.005992569029331207,
-0.0017577481921762228,
0.026155292987823486,
0.014083619229495525,
-0.019611060619354248,
0.012536800466477871,
-0.005284061189740896,
-0.015284296125173569,
-0.03762121871113777,
-0.016528241336345673,
0.01382401306182146,
-0.008621078915894032,
-0.009881248697638512,
-0.03956826403737068,
0.007523162290453911,
-0.009210600517690182,
0.01089263055473566,
-0.014819169417023659,
0.02282368391752243,
-0.005949301645159721,
0.0021160582546144724,
-0.016398437321186066,
0.00419966597110033,
-0.014829985797405243,
-0.013477872125804424,
0.023797206580638885,
0.009556741453707218,
0.011006208136677742,
0.009756854735314846,
-0.004426821134984493,
-0.011855334974825382,
-0.027128813788294792,
-0.02942200005054474,
-0.014732633717358112,
0.05174810439348221,
-0.01767483353614807,
-0.04402483254671097,
0.059579551219940186,
0.0158359594643116,
-0.007258147932589054,
0.009740629233419895,
0.017382776364684105,
0.006160231307148933,
-0.017869537696242332,
-0.004643159452825785,
0.03115270659327507,
0.03744814917445183,
-0.029746508225798607,
-0.016344353556632996,
0.025982221588492393,
0.0012763956328853965,
0.0073717255145311356,
-0.0023432134184986353,
0.018734890967607498,
0.016095565631985664,
0.0008329022093676031,
-0.03314301744103432,
0.007247331086546183,
0.014894887804985046,
0.022542444989085197,
0.04106099531054497,
0.03178008645772934,
-0.00622513284906745,
0.05196444317698479,
0.013661759905517101,
-0.007139161694794893,
-0.009102431125938892,
-0.020508864894509315,
-0.013650942593812943,
-0.021439118310809135,
-0.019254103302955627,
-0.03848657384514809,
0.014959788881242275,
-0.014354041777551174,
0.012623336166143417,
0.0013838886516168714,
0.024402953684329987,
-0.008534543216228485,
-0.0328834131360054,
0.0059114424511790276,
-0.026371631771326065,
0.008502092212438583,
-0.020443962886929512,
0.014170153997838497,
-0.035414569079875946,
-0.04238066077232361,
0.021406669169664383,
-0.001960565336048603,
0.021828528493642807,
0.03539293631911278,
0.0070580351166427135,
0.01726379059255123,
0.022120583802461624,
0.01737195998430252,
-0.013380520045757294,
-0.0037453556433320045,
-0.052094247192144394,
0.015608803369104862,
-0.01901613175868988,
-0.0035506512504070997,
0.016971735283732414,
-0.015987396240234375,
-0.05114235728979111,
-0.011033250018954277,
0.004359215497970581,
-0.006690260022878647,
-0.00860485341399908,
-0.006760569754987955,
0.000321803119732067,
0.005646428093314171,
0.009848798625171185,
0.007680007256567478,
-0.03184498846530914,
-0.0011242827167734504,
0.00508124427869916,
0.015067958272993565,
-0.011941870674490929,
-0.0048919483087956905,
-0.03827023506164551,
-0.0013311562361195683,
0.0038832712452858686,
0.0054354979656636715,
-0.019665146246552467,
-0.008821191266179085,
-0.0008153247181326151,
-0.002724509686231613,
0.05737290158867836,
0.0181940458714962,
0.012926209717988968,
-0.020422330126166344,
-0.011541645042598248,
-0.014851619489490986,
0.003401918802410364,
0.017490945756435394,
0.0328834131360054,
0.037058740854263306,
-0.03158538416028023,
-0.009675727225840092,
-0.011595729738473892,
-0.027799462899565697,
-0.02591732144355774,
-0.005878991447389126,
0.008621078915894032,
0.017490945756435394,
-0.035739075392484665,
-0.01962187886238098,
-0.013023561798036098,
0.023407796397805214,
0.0029827633406966925,
-0.0016238888492807746,
-0.01605229638516903,
-0.014007900841534138,
-0.01028688345104456,
-0.015143676660954952,
0.030308986082673073,
0.008610261604189873,
0.028145603835582733,
-0.004513356368988752,
0.025484643876552582,
-0.010351784527301788,
0.03671259805560112,
0.025852419435977936,
0.019459623843431473,
-0.03322955220937729,
-0.02384047396481037,
0.016917649656534195,
-0.00016538043564651161,
-0.02498706616461277,
0.013672576285898685,
0.024402953684329987,
-0.004821638576686382,
-0.002796171698719263,
0.038205333054065704,
-0.002156621776521206,
-0.008664346300065517,
-0.021298499777913094,
-0.018529370427131653,
0.006214316003024578,
-0.007463668938726187,
0.020487230271100998,
-0.005024455487728119,
-0.0033424256835132837,
0.00868597999215126,
-0.0020051850005984306,
-0.0223044715821743,
0.008750881999731064,
0.002573072910308838,
-0.01460283063352108,
0.009432347491383553,
-0.013380520045757294,
-0.05109909176826477,
-0.06438226252794266,
0.0153816482052207,
0.0216987244784832,
-0.014894887804985046,
-0.0026001152582466602,
-0.018280580639839172,
0.013045195490121841,
0.04893570765852928,
-0.03619338572025299,
0.0038102571852505207,
0.024013543501496315,
0.05261345952749252,
-0.005492286756634712,
0.0205521322786808,
0.008199218660593033,
0.028513379395008087,
-0.016896016895771027,
-0.013348069041967392,
-0.01726379059255123,
-0.001719888998195529,
0.029443634673953056,
-0.010611390694975853,
0.01009758748114109,
0.02589568682014942,
-0.004529581870883703,
0.006571273785084486,
-0.008880684152245522,
-0.021709542721509933,
0.018778158351778984,
-0.018258947879076004,
-0.012893758714199066,
-0.016885198652744293,
-0.011552461422979832,
-0.03617175295948982,
0.013488689437508583,
0.04032544791698456,
-0.006884964182972908,
0.012590885162353516,
0.017966890707612038,
0.04132060334086418,
-0.01633353717625141,
-0.031607016921043396,
0.011314489878714085,
0.04763767868280411,
0.0014278324088081717,
0.00787471141666174,
-0.011422659270465374,
-0.017112353816628456,
-0.01613883301615715,
0.006084512919187546,
-0.0022458613384515047,
-0.03247236832976341,
0.010157080367207527,
-0.00001567607068864163,
-0.00838310644030571,
0.010346376337110996,
-0.0046783145517110825,
0.023104922845959663,
0.0017929031746461987,
-0.006901189684867859,
0.001008000923320651,
-0.011033250018954277,
-0.00264067854732275,
-0.022347738966345787,
0.0031585381366312504,
-0.03262380510568619,
0.0033667637035250664,
-0.000782197923399508,
0.004321356303989887,
-0.017718100920319557,
-0.005792456213384867,
-0.007377133704721928,
-0.01460283063352108,
0.0060358368791639805,
0.00663076713681221,
-0.01973004639148712,
0.029768140986561775,
-0.022910218685865402,
-0.01460283063352108,
-0.04090955853462219,
-0.008026148192584515,
-0.0024608473759144545,
0.010578939691185951,
-0.05810844898223877,
0.001633353647775948,
0.0016144240507856011,
-0.021103795617818832,
0.018669988960027695,
0.02983304299414158,
-0.0018158890306949615,
0.030287353321909904,
-0.023883741348981857,
0.00960541795939207,
0.0024919460993260145,
0.027821097522974014,
-0.016268635168671608,
-0.019849032163619995,
-0.003934651613235474,
-0.021655457094311714,
-0.014072801917791367,
-0.022499175742268562,
-0.02572261542081833,
0.011855334974825382,
-0.022780416533350945,
-0.0074744862504303455,
-0.010806094855070114,
-0.012125758454203606,
0.0006550992256961763,
0.030482057482004166,
-0.04646945372223854,
-0.010962939821183681,
-0.012590885162353516,
0.019611060619354248,
0.01975168101489544,
0.0375346839427948,
-0.02745332196354866,
0.00030794396298006177,
-0.008058599196374416,
0.022650612518191338,
-0.034505948424339294,
0.010308517143130302,
0.02652306854724884,
-0.009216008707880974,
-0.024424586445093155,
0.0386812761425972,
0.018020974472165108,
-0.021320132538676262,
-0.00330456648953259,
-0.022499175742268562,
0.015154493041336536,
0.0036534119863063097,
-0.047767482697963715,
0.015792692080140114,
0.007041809614747763,
0.02572261542081833,
0.02071438543498516,
0.026804307475686073,
-0.047767482697963715,
0.015370831824839115,
-0.009324178099632263,
-0.015803508460521698,
-0.006106146611273289,
-0.00246896012686193,
-0.017436861991882324,
0.011238771490752697,
0.00740417605265975,
0.006046653725206852,
0.04090955853462219,
0.0003424228634685278,
0.003461411688476801,
0.00591685064136982,
-0.016841931268572807,
-0.012071673758327961,
0.023083290085196495,
-0.009854206815361977,
0.003426256822422147,
0.010086770169436932,
0.018561821430921555,
0.017242157831788063,
0.0528297983109951,
0.017609931528568268,
-0.02159055508673191,
-0.0029422000516206026,
0.0006713246111758053,
0.00497848354279995,
-0.0278643649071455,
0.006003385875374079,
0.1132747009396553,
-0.01564125530421734,
-0.008637304417788982,
0.014765084721148014,
-0.01717725582420826,
-0.009675727225840092,
0.020952358841896057,
0.006657809019088745,
0.03467901796102524,
-0.02148238755762577,
0.006446879357099533,
0.007674599066376686,
0.03662606328725815,
0.014775901101529598,
0.03695056959986687,
-0.0017699172021821141,
0.004989300388842821,
0.035111695528030396,
-0.00034309891634620726,
0.0013054660521447659,
-0.003699383931234479,
0.01361849159002304,
-0.001687438227236271,
0.027193715795874596,
-0.03415980562567711,
0.003272115718573332,
0.0023296924773603678,
0.004551215562969446,
0.013759111985564232,
-0.024857264012098312,
0.002136340131983161,
0.02518177032470703,
0.012558434158563614,
0.0038697500713169575,
-0.012266377918422222,
-0.01838875003159046,
-0.011033250018954277,
-0.01464609894901514,
0.012580068781971931,
0.008361472748219967,
-0.01197432167828083,
0.011660630814731121,
-0.009540515951812267,
0.00365070765838027,
0.011638997122645378,
0.00946479756385088,
0.002696115290746093,
0.010389643721282482,
0.006528006400913,
-0.036258287727832794,
0.0018551003886386752,
-0.017079902812838554,
0.016474155709147453,
-0.028816252946853638,
-0.043137844651937485,
-0.03472228720784187,
-0.0051813009195029736,
-0.006441471166908741,
0.016668861731886864,
-0.015230211429297924,
-0.01679866388440132,
0.01613883301615715,
0.020433146506547928,
-0.01136857457458973,
-0.0006348175229504704
] | 2024-07-19 | 128 | 39026380 | [
"hematopoietic stem cell transplantation",
"other treatments",
"treatment tolerance",
"CAR-T cell therapy",
"CAR-T cells",
"Chimeric antigen receptor-T cell therapy",
"targeted drugs",
"immune checkpoint inhibitors",
"certain cases",
"hematologic malignancies",
"patient response",
"different mechanisms",
"clinical applications",
"challenges",
"survival rates",
"relapse rates",
"remarkable success",
"combinations",
"a groundbreaking cancer treatment",
"therapeutic efficacy",
"tumors",
"chemotherapy",
"radiotherapy",
"research",
"researchers",
"CAR-T monotherapy",
"the basic principles",
"the antitumor effects",
"these challenges",
"These combinations"
] | [
"Chimeric antigen receptor T cell therapy",
"Combination therapy",
"Complete remission rate",
"Hematologic malignancies",
"Hematopoietic stem cell transplantation",
"Malignant tumor",
"Multiple myeloma"
] | 0 | 10.1186/s40164-024-00536-0
10.1146/annurev-pharmtox-031720-102211
10.1158/2159-8290.CD-12-0548
10.1200/JCO.19.02103
10.1038/s41591-021-01436-0
10.1186/s40164-023-00373-7
10.1016/S1470-2045(21)00375-2
10.1056/NEJMoa1708566
10.1056/NEJMoa2024850
10.1200/JCO.22.00642
10.1056/NEJMoa1707447
10.1056/NEJMoa1914347
10.1016/S0140-6736(20)31366-0
10.1056/NEJMoa1709866
10.1016/S1470-2045(21)00591-X
10.1056/NEJMc2030164
10.1200/JCO.21.02370
10.1056/NEJMoa1709919
10.1200/JCO.19.02104
10.1158/2159-8290.CD-15-1020
10.3389/fimmu.2023.1165870
10.1158/2159-8290.CD-18-0442
10.1182/blood-2015-08-665547
10.1111/bjh.13562
10.1016/j.ccell.2017.03.002
10.1126/scitranslmed.aaa0984
10.1056/NEJMoa1215134
10.1038/nm.4441
10.1038/s41591-018-0146-z
10.1200/JCO.2018.77.8084
10.1172/JCI126397
10.1038/s41591-023-02491-5
10.1038/s41586-018-0756-0
10.1038/s41590-023-01569-z
10.1016/j.immuni.2023.09.001
10.1016/j.ymthe.2021.12.013
10.1182/blood-2008-12-195792
10.1158/0008-5472.CAN-11-1620
10.1038/s41591-018-0010-1
10.1016/j.ccell.2023.01.009
10.1038/s41571-019-0297-y
10.1182/blood.2021011597
10.1158/2159-8290.CD-21-1026
10.1182/blood.2019000050
10.1158/1078-0432.CCR-17-0344
10.1007/s13402-023-00833-6
10.1158/1535-7163.MCT-18-1146
10.1182/bloodadvances.2022007317
10.1182/blood.2019002936
10.21037/atm-22-20
10.3389/fonc.2019.00767
10.1016/j.ijrobp.2022.12.017
10.1016/j.ijrobp.2019.05.065
10.1158/1078-0432.CCR-21-0308
10.1002/ctm2.176
10.1038/s41392-022-00924-0
10.1056/NEJMoa2114110
10.1056/NEJMoa2211582
10.1016/S1470-2045(22)00293-5
10.1186/s13045-016-0250-9
10.1056/NEJMoa2300696
10.1016/S0140-6736(21)00224-5
10.1182/blood-2015-11-679134
10.1172/JCI89756
10.1158/0008-5472.CAN-15-1490
10.1002/ijc.33212
10.1016/j.jcyt.2023.03.005
10.1158/1078-0432.CCR-15-1527
10.1097/CJI.0000000000000307
10.1186/s40164-024-00484-9
10.1158/0008-5472.CAN-16-1925
10.1038/s41375-017-0008-6
10.1038/cdd.2015.50
10.1054/drup.2000.0142
10.1016/j.stem.2012.12.011
10.1016/j.ccr.2004.07.011
10.1002/ptr.5766
10.1038/nrc.2015.17
10.1200/JCO.2011.37.0981
10.1182/blood-2018-08-868752
10.1038/s41591-018-0233-1
10.1038/79802
10.1016/j.it.2018.07.002
10.1016/j.coi.2005.04.005
10.1038/ncomms8333
10.1016/j.canlet.2015.07.048
10.1038/s41591-022-02182-7
10.3389/fimmu.2021.599493
10.1146/annurev-immunol-041015-055318
10.1038/nri.2016.80
10.1016/j.ctrv.2017.01.009
10.1182/blood-2016-09-738245
10.1182/bloodadvances.2023011287
10.1016/j.intimp.2023.110092
10.1038/s41598-021-99311-y
10.1111/imm.13624
10.1038/cr.2016.142
10.1038/s41598-017-00462-8
10.1007/s00262-018-2281-2
10.1186/s13045-020-00910-5
10.1002/adhm.202301515
10.1172/JCI83092
10.1136/jitc-2023-008429
10.18632/oncotarget.9114
10.1158/1078-0432.CCR-17-0867
10.1016/j.omto.2021.03.014
10.1186/s12943-023-01830-x
10.1016/j.ijrobp.2009.04.018
10.1038/s41392-022-01102-y
10.3389/fonc.2021.648655
10.1007/s13277-012-0329-z
10.1016/j.freeradbiomed.2007.10.048
10.1016/j.ymthe.2018.09.008
10.1186/s13045-017-0502-3
10.1186/s13045-020-00860-y
10.1158/1078-0432.CCR-15-2335
10.1182/blood-2015-02-627786
10.1200/JCO.19.03011
10.1186/s13045-021-01159-2 | [
"Zhou",
"Zhu",
"Xiao"
] | [
"1Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.",
"1Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. [email protected].",
"1Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. [email protected]."
] | [
"39026380",
"30652353",
"33035447",
"23550147",
"32667831",
"34312556",
"36707873",
"34516954",
"29226764",
"33626253",
"36399695",
"29226797",
"32242358",
"32888407",
"29385370",
"34895487",
"33596362",
"35658525",
"29385376",
"32401634",
"26516065",
"37122700",
"30135176",
"26907630",
"26084925",
"28366678",
"28724573",
"23527958",
"29155426",
"30275569",
"29812997",
"30896447",
"37653344",
"30487606",
"37488429",
"37776850",
"34933101",
"19423728",
"22186141",
"29713085",
"36801000",
"29033130",
"36520915",
"31848460",
"35084470",
"35904479",
"31558469",
"29061640",
"37219767",
"31395689",
"35349631",
"32076701",
"35433994",
"31482064",
"38564164",
"36563910",
"31175906",
"34526365",
"34425260",
"32997409",
"36483984",
"35399106",
"35196427",
"20615965",
"36796019",
"36511784",
"35810754",
"26957112",
"37407001",
"33676628",
"26813675",
"28714866",
"23886836",
"26880800",
"32683672",
"37074239",
"26819453",
"31899702",
"38326887",
"28615225",
"29479065",
"25952548",
"11498379",
"23333150",
"15380515",
"28144994",
"26822577",
"22649144",
"30361262",
"30420752",
"10973284",
"30072119",
"15886118",
"26065893",
"26341688",
"36690811",
"34113336",
"30676822",
"27526640",
"28242522",
"28031179",
"37903325",
"37004344",
"34611279",
"36640111",
"27910851",
"28389661",
"30523370",
"32616000",
"37602495",
"27454297",
"38589248",
"27145284",
"28912137",
"33981830",
"37563723",
"19632068",
"35906199",
"33842363",
"22322922",
"18060882",
"30415658",
"28676064",
"32228710",
"26927664",
"25940714",
"31860405",
"34526099"
] | [] | 8.294635 | 3.979207 |
39024031 | 713 | Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy. | The purpose of this study was to investigate the remodeling of the multiple myeloma microenvironment after B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor T (CAR-T) cell therapy.
We performed single-cell RNA sequencing on paired bone marrow specimens (n = 14) from seven patients with multiple myeloma before (i.e., baseline, "day -4") and after (i.e., "day 28") lymphodepleted BCMA CAR-T cell therapy.
Our analysis revealed heterogeneity in gene expression profiles among multiple myeloma cells, even those harboring the same cytogenetic abnormalities. The best overall responses of patients over the 15-month follow-up are positively correlated with the abundance and targeted cytotoxic activity of CD8+ effector CAR-T cells on day 28 after CAR-T cell infusion. Additionally, favorable responses are associated with attenuated immunosuppression mediated by regulatory T cells, enhanced CD8+ effector T-cell cytotoxic activity, and elevated type 1 conventional dendritic cell (DC) antigen presentation ability. DC re-clustering inferred intramedullary-originated type 3 conventional DCs with extramedullary migration. Cell-cell communication network analysis indicated that BCMA CAR-T therapy mitigates BAFF/GALECTIN/MK pathway-mediated immunosuppression and activates MIF pathway-mediated anti-multiple myeloma immunity.
Our study sheds light on multiple myeloma microenvironment dynamics after BCMA CAR-T therapy, offering clues for predicting treatment responsivity. | [
0.014044723473489285,
0.02325141802430153,
0.05093168094754219,
0.029702123254537582,
-0.05420517176389694,
-0.01742652989923954,
0.02652491070330143,
0.011589604429900646,
-0.026356421411037445,
-0.014417805708944798,
0.004130978137254715,
0.005220136139541864,
-0.05921168625354767,
0.007762508001178503,
0.03694713115692139,
0.010175504721701145,
0.034780848771333694,
0.00643265200778842,
0.01754687912762165,
0.05810447782278061,
-0.005481895059347153,
-0.011102191172540188,
-0.0004682326689362526,
-0.005854976829141378,
-0.022180313244462013,
-0.002446092665195465,
-0.023528221994638443,
-0.011385011486709118,
-0.00676962872967124,
-0.025562118738889694,
-0.027271073311567307,
-0.025104792788624763,
-0.01303379237651825,
0.00207902817055583,
-0.0666251853108406,
0.026212003082036972,
0.02238490618765354,
-0.020615777000784874,
-0.017450598999857903,
-0.05160563439130783,
0.022974615916609764,
0.006062578875571489,
-0.006528931204229593,
0.06315913051366806,
-0.05892284959554672,
-0.010506464168429375,
-0.04115934297442436,
-0.045588184148073196,
0.06118541210889816,
0.03475677967071533,
-0.02674153819680214,
0.014056758023798466,
-0.03697120025753975,
0.009098381735384464,
-0.03312003239989281,
0.003318622475489974,
-0.000049361879064235836,
0.013804025948047638,
0.0114752734079957,
0.004446893930435181,
0.012046930380165577,
-0.012173296883702278,
-0.0102838184684515,
-0.01754687912762165,
-0.03959480673074722,
-0.04330155625939369,
-0.05892284959554672,
-0.03519003465771675,
0.028402354568243027,
-0.011264662258327007,
0.017390424385666847,
-0.014995479956269264,
-0.006902012974023819,
0.033649567514657974,
0.024021651595830917,
-0.0021783162374049425,
0.008346199989318848,
0.009134486317634583,
-0.03790992125868797,
-0.019604844972491264,
0.0310259610414505,
0.013707746751606464,
0.029317006468772888,
-0.030183518305420876,
0.005707549396902323,
0.010181521996855736,
0.03981143608689308,
-0.01398454885929823,
-0.05295354127883911,
0.01864205300807953,
0.0017525816801935434,
-0.016391528770327568,
-0.05757494270801544,
0.05632331222295761,
0.025177001953125,
0.00044641943532042205,
-0.013912339694797993,
-0.068791463971138,
0.01785978488624096,
0.016379494220018387,
0.030327938497066498,
0.021325835958123207,
-0.009423323906958103,
-0.014141002669930458,
0.04012434184551239,
-0.040509458631277084,
-0.014261351898312569,
-0.004194161389023066,
0.006817768327891827,
0.0015367057640105486,
0.05507168546319008,
0.001666833064518869,
-0.002716877730563283,
0.024142000824213028,
0.0010034095030277967,
-0.007882856763899326,
-0.02722293511033058,
-0.015368562191724777,
-0.001535201445221901,
0.01708955131471157,
-0.0242864191532135,
0.053916335105895996,
0.012889373116195202,
-0.03396247699856758,
0.006902012974023819,
-0.02237287163734436,
0.07798612862825394,
-0.005815863609313965,
-0.06758797913789749,
-0.04821179434657097,
0.03451608121395111,
0.002351317787542939,
0.015825888141989708,
-0.025225142017006874,
-0.06484401971101761,
0.0035533029586076736,
-0.02505665272474289,
-0.018918856978416443,
-0.03559922054409981,
-0.03564736247062683,
0.014959375374019146,
0.00044867597171105444,
0.017931994050741196,
0.004443885292857885,
-0.04708051308989525,
-0.03124259039759636,
0.01944839209318161,
0.028522703796625137,
0.006492826156318188,
0.01989368349313736,
-0.04371074214577675,
0.06335169076919556,
0.017125656828284264,
0.027271073311567307,
0.04720086231827736,
-0.07442379742860794,
0.002704842947423458,
0.05040214583277702,
-0.02551397867500782,
-0.06498843431472778,
0.011625709012150764,
0.006787681486457586,
-0.03990771621465683,
-0.02541770040988922,
0.02529735118150711,
0.012564430944621563,
-0.026139793917536736,
0.05526424199342728,
-0.08660311251878738,
-0.03526224568486214,
0.00954367220401764,
-0.017173796892166138,
-0.06782867014408112,
-0.04958377033472061,
-0.057960059493780136,
0.00995285902172327,
0.018437460064888,
-0.02461136132478714,
-0.03225352242588997,
-0.02337176725268364,
-0.013142106123268604,
0.01119245309382677,
0.037717364728450775,
0.018979031592607498,
-0.03981143608689308,
-0.007335268892347813,
-0.02315513975918293,
0.07090960443019867,
-0.015428736805915833,
-0.00483501935377717,
0.007347303908318281,
0.007792595308274031,
0.06166680529713631,
0.013707746751606464,
0.006104700732976198,
-0.014802921563386917,
0.04103899374604225,
0.043758880347013474,
-0.04250725358724594,
-0.009014137089252472,
0.047730397433042526,
-0.014429840259253979,
-0.01998996175825596,
-0.01123457495123148,
-0.015163969248533249,
0.020627811551094055,
-0.02710258588194847,
0.012034895829856396,
-0.012600536458194256,
0.037933990359306335,
0.04664725810289383,
0.02440676838159561,
-0.012052948586642742,
0.03685085102915764,
-0.03381805866956711,
-0.04236283525824547,
-0.03831910714507103,
0.013178210705518723,
0.009038207121193409,
0.02922072820365429,
0.042073994874954224,
-0.0013546779518947005,
0.028643053025007248,
0.047176793217659,
-0.006926082540303469,
0.01522414293140173,
0.025802817195653915,
-0.019388217478990555,
-0.01303379237651825,
-0.02112124301493168,
0.013563327491283417,
0.02045932225883007,
-0.006002404261380434,
-0.02585095725953579,
-0.01180623285472393,
-0.03742852807044983,
0.04127969220280647,
0.013635536655783653,
0.059837501496076584,
-0.014032688923180103,
-0.0005080982809886336,
0.02439473383128643,
0.03745259717106819,
0.01946042664349079,
-0.01439373567700386,
0.027487702667713165,
-0.017221936956048012,
-0.07760100811719894,
0.015368562191724777,
-0.0016653287457302213,
-0.029268866404891014,
0.022745953872799873,
-0.025682467967271805,
-0.022445080801844597,
-0.01213719230145216,
0.014285421930253506,
0.017005307599902153,
0.027824679389595985,
-0.0027740434743463993,
-0.032542359083890915,
-0.0038632017094641924,
-0.01651187799870968,
-0.038728296756744385,
-0.007275094743818045,
-0.0005306637031026185,
0.022637639194726944,
0.004389728419482708,
0.0016397546278312802,
0.047874815762043,
-0.006065587513148785,
-0.004889176692813635,
0.0029229754582047462,
0.031290728598833084,
-0.005960282403975725,
-0.04036504030227661,
-0.009627916850149632,
-0.031651776283979416,
0.006032491568475962,
0.013779955916106701,
-0.009369166567921638,
-0.00922474730759859,
0.01998996175825596,
0.01729414612054825,
0.0019120441284030676,
0.009290939196944237,
-0.009934806264936924,
0.012227454222738743,
0.02796909771859646,
-0.018979031592607498,
-0.02977433241903782,
-0.008731316775083542,
-0.00007249144255183637,
-0.008923875167965889,
-0.041544459760189056,
-0.029413284733891487,
0.003387823235243559,
0.005114830564707518,
-0.032662708312273026,
-0.04561225697398186,
0.092572420835495,
-0.016933098435401917,
0.003318622475489974,
-0.04140004143118858,
-0.01912344992160797,
0.018232867121696472,
0.025538049638271332,
-0.020387113094329834,
-0.03475677967071533,
-0.004290440585464239,
0.04527527838945389,
-0.0025393629912286997,
-0.019628915935754776,
0.01118041854351759,
0.035141896456480026,
0.004431850276887417,
-0.007756490260362625,
-0.0035833902657032013,
-0.029172588139772415,
0.02012234553694725,
-0.03461236134171486,
-0.06912843883037567,
-0.009357132017612457,
-0.051316797733306885,
-0.003249421948567033,
0.012913443148136139,
-0.02686188742518425,
0.005539061035960913,
-0.03268677741289139,
0.01546484138816595,
-0.05752680078148842,
0.03990771621465683,
-0.05271284282207489,
0.07115030288696289,
0.028498632833361626,
0.000054674157581757754,
-0.009561724960803986,
-0.04012434184551239,
-0.011812250129878521,
0.009260852821171284,
0.01687292382121086,
-0.008935910649597645,
0.025249211117625237,
-0.022396940737962723,
0.038270968943834305,
0.01854577474296093,
-0.009531637653708458,
0.0024566231295466423,
0.01269681565463543,
-0.031098170205950737,
0.006763611454516649,
0.027126654982566833,
-0.026958167552947998,
0.04780260846018791,
0.007245007436722517,
0.02000199630856514,
0.003475076286122203,
-0.03239794075489044,
-0.009922771714627743,
0.03001503087580204,
-0.004091864451766014,
0.004865106660872698,
0.02089257910847664,
0.0006728259031660855,
0.019640950486063957,
0.038391318172216415,
0.07736030966043472,
0.0062220413237810135,
0.02392537333071232,
-0.033986546099185944,
0.0015043619787320495,
-0.026380492374300957,
-0.005250223446637392,
0.024214209988713264,
0.011318819597363472,
-0.051750052720308304,
0.029702123254537582,
-0.0046033477410674095,
0.022974615916609764,
-0.015163969248533249,
-0.011445186100900173,
0.030376076698303223,
-0.02878747135400772,
0.015404666773974895,
-0.06397750973701477,
-0.010061172768473625,
0.03896899148821831,
0.004136995412409306,
0.0015600234037265182,
-0.08872125297784805,
0.015825888141989708,
-0.024081826210021973,
-0.02551397867500782,
-0.0031411077361553907,
-0.010867510922253132,
-0.03319224342703819,
0.04282015934586525,
-0.006101692095398903,
0.07163169980049133,
0.06537355482578278,
0.012516291812062263,
-0.0004539412329904735,
-0.03612875938415527,
-0.025441769510507584,
-0.06277401745319366,
0.006252128630876541,
-0.0025950244162231684,
-0.01056663878262043,
-0.0420258566737175,
0.01931600831449032,
0.004705644212663174,
-0.01855780929327011,
-0.019412286579608917,
0.027680261060595512,
0.003992576617747545,
0.021073102951049805,
-0.020146416500210762,
-0.07967101037502289,
0.06667332351207733,
0.025586187839508057,
0.02775247022509575,
0.024418802931904793,
-0.03976329788565636,
0.03256642818450928,
-0.025441769510507584,
0.0014163567684590816,
-0.014694607816636562,
0.028594912961125374,
0.0007995683699846268,
0.008219833485782146,
-0.05545680224895477,
-0.03762108460068703,
0.04192957654595375,
0.019171589985489845,
-0.02214420773088932,
0.015777748078107834,
0.03213317319750786,
-0.04554004594683647,
0.020290834829211235,
-0.052424006164073944,
0.011282715015113354,
-0.00025480129988864064,
-0.007618089206516743,
-0.028233865275979042,
-0.03901713341474533,
0.0101093128323555,
0.027848748490214348,
-0.011535448022186756,
0.010650882497429848,
-0.024190140888094902,
-0.015236178413033485,
0.01788385584950447,
-0.027247004210948944,
-0.006342390086501837,
0.03011130914092064,
-0.028715262189507484,
-0.0016683374997228384,
0.022192347794771194,
-0.06455518305301666,
0.018726298585534096,
0.005427738185971975,
0.04267574101686478,
-0.06267774105072021,
0.01900310069322586,
-0.013118037022650242,
0.0008356730686500669,
0.023431941866874695,
0.020603742450475693,
-0.02215624414384365,
0.014032688923180103,
-0.022276591509580612,
0.042651671916246414,
0.01073512714356184,
-0.023877233266830444,
0.010933702811598778,
-0.02924479730427265,
0.0075157927349209785,
0.011715970933437347,
0.004146021790802479,
0.06831006705760956,
-0.00752782728523016,
0.0007484200759790838,
-0.02292647585272789,
-0.029485495761036873,
0.00008386818080907688,
0.026236074045300484,
0.043879229575395584,
-0.03641759604215622,
0.032085031270980835,
-0.027150725945830345,
0.007509774994105101,
-0.00843646191060543,
-0.014790887013077736,
0.002522815018892288,
-0.011709953658282757,
-0.004365658387541771,
-0.04700830206274986,
0.01073512714356184,
-0.00203540176153183,
-0.026813747361302376,
0.012119140475988388,
-0.018268972635269165,
0.042892370373010635,
0.036586083471775055,
0.008388322778046131,
-0.00016642003902234137,
0.036586083471775055,
-0.051316797733306885,
0.04845249280333519,
0.007696316111832857,
0.015332457609474659,
-0.0375729463994503,
-0.009218730032444,
0.014490014873445034,
-0.014995479956269264,
-0.009092363528907299,
-0.008731316775083542,
-0.008346199989318848,
-0.04428841546177864,
-0.022204382345080376,
0.015910131856799126,
-0.007997188717126846,
-0.007702333386987448,
0.012985652312636375,
0.024370664730668068,
0.05083540081977844,
-0.03697120025753975,
-0.01754687912762165,
-0.026260143145918846,
-0.03393840789794922,
-0.029196657240390778,
0.028618982061743736,
-0.0147186778485775,
0.01708955131471157,
0.006095674820244312,
-0.01594623737037182,
-0.025778746232390404,
-0.012564430944621563,
0.019472461193799973,
-0.009447393007576466,
-0.015043620020151138,
0.024142000824213028,
-0.0077504729852080345,
0.024539152160286903,
-0.005508973728865385,
0.010945738293230534,
0.038704223930835724,
0.02609165385365486,
-0.016355423256754875,
0.028257936239242554,
-0.02001403272151947,
0.046815745532512665,
-0.03506968542933464,
0.034684568643569946,
0.027608051896095276,
-0.0005464595160447061,
-0.009038207121193409,
-0.01571757346391678,
-0.029076308012008667,
0.010831406340003014,
-0.027511771768331528,
-0.01708955131471157,
-0.0022505256347358227,
0.041881438344717026,
-0.0036345385015010834,
-0.013238385319709778,
0.0019060266204178333,
0.0125885009765625,
-0.003887271275743842,
-0.03285526484251022,
0.02977433241903782,
0.007190850097686052,
0.019965892657637596,
0.020507462322711945,
-0.025345491245388985,
0.041761089116334915,
-0.016560016199946404,
-0.04257946088910103,
0.03812655061483383,
0.0031350904610008,
-0.022685779258608818,
-0.010626813396811485,
-0.02664525993168354,
-0.004507068544626236,
0.0350937582552433,
-0.02664525993168354,
0.0038962976541370153,
-0.017715366557240486,
-0.009724196046590805,
-0.013587397523224354,
0.007497739978134632,
0.014971410855650902,
-0.009910737164318562,
0.0310259610414505,
0.006847855634987354,
0.004615382757037878,
0.03576771169900894,
-0.003941428381949663,
-0.010217626579105854,
-0.03639352694153786,
0.002205394674092531,
0.026573050767183304,
-0.0028011221438646317,
-0.022565430030226707,
-0.025489909574389458,
0.003781965933740139,
0.07379797846078873,
0.011487307958304882,
0.006210006307810545,
-0.00014451277093030512,
0.047874815762043,
0.04712865129113197,
0.03304782509803772,
-0.030424216762185097,
0.007124658208340406,
0.03473271057009697,
0.010723092593252659,
-0.028498632833361626,
-0.02202386036515236,
0.018437460064888,
-0.016439666971564293,
-0.00551198236644268,
0.008033293299376965,
0.007347303908318281,
-0.009856579825282097,
0.025032583624124527,
-0.056034475564956665,
-0.023335663601756096,
0.008791491389274597,
0.03735631704330444,
0.03148328885436058,
-0.010885563679039478,
0.0011478281812742352,
-0.007347303908318281,
0.006252128630876541,
0.013623502105474472,
-0.013238385319709778,
0.04948749393224716,
-0.025899095460772514,
0.006002404261380434,
-0.00888175331056118,
0.01572960987687111,
-0.010927685536444187,
-0.008990067057311535,
-0.02710258588194847,
0.005175005178898573,
-0.027945028617978096,
0.0006216776091605425,
-0.01944839209318161,
-0.001739042461849749,
-0.02114531211555004,
-0.022228453308343887,
-0.017558913677930832,
0.016704436391592026,
-0.0017270075622946024,
0.013852165080606937,
-0.0284504946321249,
-0.011625709012150764,
0.014417805708944798,
0.05589005723595619,
0.049391213804483414,
-0.014646468684077263,
0.033673640340566635,
-0.014766816981136799,
-0.014261351898312569,
-0.0036555996630340815,
0.01729414612054825,
-0.008990067057311535,
-0.019520601257681847,
0.006492826156318188,
0.018268972635269165,
0.08491822332143784,
-0.031531427055597305,
0.008653090335428715,
-0.010019050911068916,
0.025177001953125,
0.0028357224073261023,
0.00905024167150259,
-0.005830907262861729,
-0.014959375374019146,
0.018954960629343987,
0.01118643581867218,
-0.008532741107046604,
-0.030616775155067444,
-0.05613075569272041,
-0.00814762432128191,
0.006733524147421122,
0.03068898431956768,
-0.003932402469217777,
0.014369665645062923,
-0.00598736060783267,
0.01785978488624096,
-0.04135190322995186,
-0.021181417629122734,
0.0041700913570821285,
0.009092363528907299,
-0.010181521996855736,
-0.00012993926065973938,
0.00390833243727684,
-0.020495427772402763,
-0.029317006468772888,
0.03249421715736389,
0.01214320957660675,
0.017679262906312943,
0.014213211834430695,
0.03497340902686119,
-0.024791885167360306,
-0.030640844255685806,
-0.036249104887247086,
0.02573060803115368,
0.00954968947917223,
-0.007768525276333094,
-0.021759090945124626,
-0.033432941883802414,
-0.03574364259839058,
-0.014237281866371632,
-0.008009223267436028,
-0.02775247022509575,
0.0317239873111248,
0.00009359951945953071,
0.013093966990709305,
-0.023407872766256332,
0.005527026019990444,
-0.031218519434332848,
-0.018918856978416443,
0.07697519659996033,
0.021951649338006973,
-0.04058166965842247,
0.039161551743745804,
-0.03078526444733143,
-0.001421622117049992,
0.01027780119329691,
-0.008322130888700485,
-0.012149227783083916,
-0.03641759604215622,
0.024129966273903847,
0.03868015483021736,
-0.014947340823709965,
-0.02202386036515236,
-0.023997582495212555,
0.004290440585464239,
0.0196770541369915,
-0.02272188290953636,
-0.03559922054409981,
0.01597030647099018,
-0.01842542551457882,
0.011866407468914986,
0.0171015877276659,
0.010362045839428902,
-0.029485495761036873,
-0.0021933598909527063,
-0.001302025280892849,
0.008725299499928951,
-0.023540256544947624,
0.0026642251759767532,
0.006685384549200535,
-0.01349111832678318,
0.01422524731606245,
0.02561025880277157,
-0.014165072701871395,
-0.007094571366906166,
-0.024466942995786667,
0.020387113094329834,
0.011108209379017353,
-0.0006397299584932625,
-0.017703332006931305,
0.012317716144025326,
0.015416701324284077,
0.003101994516327977,
0.011764110997319221,
0.024551188573241234,
-0.009639951400458813,
-0.021289730444550514,
0.03218131139874458,
-0.013623502105474472,
0.014008618891239166,
0.015825888141989708,
0.004582286812365055,
0.04599737375974655,
-0.009706143289804459,
0.004407780710607767,
-0.006492826156318188,
0.005770732648670673,
0.019929787144064903,
0.01488716620951891,
-0.015922166407108307,
0.0047537838108837605,
0.008280008099973202,
-0.011625709012150764,
-0.029509564861655235,
0.00030030825291760266,
-0.016608156263828278,
0.029413284733891487,
-0.027608051896095276,
0.012829199433326721,
-0.014128968119621277,
0.01393640972673893,
0.035478875041007996,
-0.10340382903814316,
-0.008412391878664494,
-0.016307283192873,
-0.028354214504361153,
-0.028354214504361153,
0.02662118896842003,
-0.009008119814097881,
-0.010470359586179256,
-0.023889267817139626,
-0.026139793917536736,
0.02753584273159504,
-0.002840235363692045,
0.011938616633415222,
-0.013900305144488811,
-0.004702635575085878,
-0.0027063472662121058,
-0.01269681565463543,
-0.005144917871803045,
0.009459428489208221,
0.041977718472480774,
-0.013587397523224354,
0.023564325645565987,
-0.059837501496076584,
0.04226655513048172,
-0.0020504454150795937,
0.0017330250702798367,
-0.0018714263569563627,
0.011715970933437347,
0.0005536052049137652,
-0.0038150621112436056,
0.016475772485136986,
0.008707246743142605,
-0.02225252240896225,
0.017847750335931778,
-0.025489909574389458,
-0.019400252029299736,
0.007762508001178503,
0.007226955145597458,
-0.027608051896095276,
0.012781059369444847,
-0.007894891314208508,
0.03610468655824661,
0.0004727457417175174,
0.02024269476532936,
-0.010187539272010326,
0.014080828055739403,
-0.014068793505430222,
0.0039354111067950726,
0.0018894786480814219,
-0.00045883041457273066,
0.006179919000715017,
-0.03124259039759636,
-0.01855780929327011,
0.010933702811598778,
0.0026521901600062847,
-0.028041306883096695,
-0.01842542551457882,
0.03677864372730255,
0.026573050767183304,
0.007106605917215347,
-0.023203279823064804,
0.045347489416599274,
0.046575047075748444,
-0.003803027095273137,
-0.018401356413960457,
-0.002100089332088828,
-0.025104792788624763,
0.041327834129333496,
-0.050979819148778915,
0.011776145547628403,
-0.02753584273159504,
0.04801923409104347,
-0.037500735372304916,
0.01393640972673893,
-0.02033897489309311,
0.00983250979334116,
-0.021879440173506737,
-0.0055541046895086765,
-0.013683676719665527,
0.007172797806560993,
-0.024695606902241707,
-0.03762108460068703,
-0.0014524614671245217,
0.012612571008503437,
-0.03699526935815811,
-0.015031585469841957,
0.012383908033370972,
-0.005307388957589865,
0.009982946328818798,
0.006673349998891354,
0.0008251425460912287,
-0.018028274178504944,
-0.02080833539366722,
0.01731821522116661,
-0.011120243929326534,
-0.009351113811135292,
-0.030279798433184624,
0.010350010357797146,
0.008376287296414375,
-0.009958876296877861,
0.03889678418636322,
-0.03730817884206772,
0.013996584340929985,
-0.018052343279123306,
-0.005493930075317621,
-0.0317239873111248,
0.04318120703101158,
-0.01546484138816595,
-0.0016713461373001337,
-0.003950454760342836,
0.03492526710033417,
0.0027108602225780487,
0.00022076512686908245,
-0.030737124383449554,
0.008358235470950603,
0.0005953512736596167,
0.03608061745762825,
-0.02136193960905075,
0.04440876469016075,
-0.006366460118442774,
0.07856380194425583,
0.014706642366945744,
0.018377285450696945,
-0.036176897585392,
-0.005108813289552927,
0.024984443560242653,
0.014778852462768555,
0.012660710141062737,
-0.024021651595830917,
0.013057862408459187,
-0.0010665926383808255,
0.016475772485136986,
-0.019604844972491264,
-0.02045932225883007,
-0.05078726261854172,
0.030737124383449554,
0.001994783990085125,
0.01796809956431389,
0.008749369531869888,
0.01089759822934866,
0.020194554701447487,
-0.028185727074742317,
0.017366355285048485,
-0.01641559787094593,
0.03608061745762825,
-0.009032189846038818,
-0.022071998566389084,
0.033432941883802414,
0.0042543355375528336,
0.03519003465771675,
-0.019195659086108208,
0.015874028205871582,
0.02281816303730011,
0.04977633059024811,
0.03663422167301178,
0.0002664601197466254,
0.01286530401557684,
-0.035815849900245667,
-0.009038207121193409,
0.02763212099671364,
-0.047610048204660416,
0.06932099908590317,
-0.04070201888680458,
-0.03372177854180336,
0.0032403958030045033,
-0.012528326362371445,
-0.006059570237994194,
-0.011667831800878048,
0.023865198716521263,
0.01822083257138729,
0.006318320520222187,
-0.07158356159925461,
0.053675636649131775,
-0.011463237926363945,
-0.018750367686152458,
-0.004705644212663174,
0.0125885009765625,
-0.006258145906031132,
0.024767816066741943,
0.021554498001933098,
-0.016114724799990654,
-0.0171015877276659,
-0.014177107252180576,
0.006510878913104534,
0.016054552048444748,
-0.00954367220401764,
-0.0067395418882369995,
-0.004121951758861542,
0.01118041854351759,
0.007636141497641802,
-0.035575151443481445,
-0.0012538856826722622,
0.01876240223646164,
0.07606054097414017,
0.032758988440036774,
-0.025682467967271805,
-0.003318622475489974,
0.05040214583277702,
-0.02628421224653721,
-0.03855980560183525,
-0.027126654982566833,
0.03437166288495064,
0.030953751876950264,
-0.03011130914092064,
0.011661814525723457,
-0.001680372399277985,
-0.004362649749964476,
-0.01988164894282818,
-0.04106306657195091,
0.059741225093603134,
0.012552396394312382,
0.02664525993168354,
-0.024190140888094902,
0.009266870096325874,
0.021446185186505318,
-0.015200073830783367,
-0.00999498087912798,
-0.008586898446083069,
-0.030183518305420876,
0.0011327845277264714,
-0.023913338780403137,
-0.03957073763012886,
0.016909029334783554,
-0.0007190850446932018,
0.012564430944621563,
0.021554498001933098,
0.02125362679362297,
0.00606859615072608,
-0.02505665272474289,
0.01270885020494461,
-0.026693399995565414,
0.02032693848013878,
0.01151739526540041,
-0.0028928881511092186,
0.01045230682939291,
-0.008616985753178596,
-0.005683479830622673,
-0.02573060803115368,
0.015573155134916306,
-0.013647572137415409,
0.021398045122623444,
0.009754283353686333,
-0.0023543264251202345,
-0.02036304399371147,
-0.026163863018155098,
-0.011529430747032166,
0.04144818335771561,
-0.050305865705013275,
-0.02316717430949211,
-0.01911141537129879,
-0.003676660591736436,
0.03169991448521614,
-0.008033293299376965,
0.03593619912862778,
0.01720990054309368,
0.017378389835357666,
0.0012862294679507613,
0.0046364436857402325,
0.05083540081977844,
0.004513085819780827,
-0.006817768327891827,
-0.02857084386050701,
-0.02505665272474289,
-0.012064983136951923,
0.014056758023798466,
-0.0022986652329564095,
-0.022168278694152832,
-0.003715774044394493,
-0.0024445883464068174,
0.03807841241359711,
0.006092666182667017,
0.006811751052737236,
-0.015669435262680054,
0.01246815174818039,
0.014658503234386444,
0.018726298585534096,
0.008418410085141659,
-0.0007525570690631866,
0.01197472121566534,
0.014321526512503624,
0.0019782360177487135,
0.01787182129919529,
0.005427738185971975,
-0.013057862408459187,
0.012781059369444847,
0.02493630349636078,
-0.035117827355861664,
-0.01777554117143154,
0.00945341121405363,
-0.022962581366300583,
-0.02474374696612358,
0.017342284321784973,
0.0194243211299181,
0.012901408597826958,
-0.00047199358232319355,
-0.024142000824213028,
-0.011433151550590992,
-0.02338380366563797,
-0.005791793577373028,
-0.018930891528725624,
-0.015609259717166424,
0.025899095460772514,
-0.00843646191060543,
-0.04407178983092308,
0.00036255124723538756,
-0.014465944841504097,
-0.00922474730759859,
-0.03396247699856758,
0.014044723473489285,
-0.012925478629767895,
-0.04631027951836586,
-0.004756792448461056,
0.009465445764362812,
-0.005481895059347153,
0.009104399010539055,
-0.01787182129919529,
-0.012961583212018013,
0.014851061627268791,
0.013972514308989048,
0.014995479956269264,
0.0036375473719090223,
0.001915052765980363,
0.002086549997329712,
0.010602743364870548,
-0.03290340676903725,
-0.028859680518507957,
0.005217127501964569,
-0.02148228883743286,
-0.012275594286620617,
-0.0029981934931129217,
0.014790887013077736,
-0.01720990054309368,
0.0017661210149526596,
-0.0011839328799396753,
0.0069742221385240555,
0.030713055282831192,
0.00573763670399785,
-0.005102796014398336,
0.01575367897748947,
-0.00025762198492884636,
-0.01653594709932804,
-0.014706642366945744,
0.01102396473288536,
-0.005259249359369278,
0.0003522087645251304,
-0.0006653040763922036,
0.019376182928681374,
-0.009134486317634583,
-0.017619088292121887,
0.002632633550092578,
0.05661214888095856,
-0.020712055265903473,
-0.015163969248533249,
0.018028274178504944,
0.011547482572495937,
-0.01045230682939291,
-0.011246610432863235,
0.0519426092505455,
-0.03044828586280346,
0.022312697023153305,
-0.019183624535799026,
0.03834317997097969,
0.03302375599741936,
-0.021289730444550514,
0.028065377846360207,
0.005524017382413149,
-0.04325341433286667,
0.017787575721740723,
0.014742747880518436,
0.035141896456480026,
0.005966299679130316,
-0.0012553901178762317,
-0.002068497706204653,
-0.007455618120729923,
-0.035021547228097916,
0.01011533010751009,
0.015898097306489944,
0.013106001541018486,
0.01456222403794527,
0.054108891636133194,
0.012287628836929798,
-0.011282715015113354,
0.009700126014649868,
-0.03283119574189186,
-0.02890782058238983,
-0.030977822840213776,
-0.025923166424036026,
-0.026260143145918846,
0.041087135672569275,
-0.033697709441185,
0.025321420282125473,
-0.03162770718336105,
0.026043515652418137,
0.013166176155209541,
-0.027295144274830818,
-0.0014652485260739923,
0.017354320734739304,
0.027030376717448235,
-0.0125403618440032,
0.006414599716663361,
-0.012347803451120853,
-0.008346199989318848,
0.016102690249681473,
0.012064983136951923,
0.0002501001872587949,
0.010325940325856209,
0.024117931723594666,
0.019051240757107735,
0.0006352168275043368,
-0.0017766514793038368,
-0.012817163951694965,
-0.0004791393002960831,
-0.07317216694355011,
0.015236178413033485,
-0.01890682242810726,
-0.006330355070531368,
-0.008382304571568966,
-0.01988164894282818,
-0.024190140888094902,
-0.009200678206980228,
0.009044224396348,
-0.0012283115647733212,
0.0030072196386754513,
0.01618693582713604,
-0.028354214504361153,
-0.018184727057814598,
0.030737124383449554,
-0.012817163951694965,
-0.0048109497874975204,
0.00022753475059289485,
0.022625604644417763,
0.00542472954839468,
0.017799610272049904,
0.0025077713653445244,
-0.03340887278318405,
0.015368562191724777,
-0.04493829980492592,
0.012269576080143452,
-0.033769916743040085,
0.005208101123571396,
0.0013659606920555234,
0.00330357882194221,
0.027463631704449654,
0.04751376807689667,
0.019051240757107735,
-0.03504561632871628,
-0.0063062855042517185,
-0.013106001541018486,
0.04640655964612961,
-0.008466549217700958,
0.025369560346007347,
0.005114830564707518,
-0.010470359586179256,
-0.001874434994533658,
-0.028715262189507484,
-0.005653392523527145,
-0.015898097306489944,
-0.022757988423109055,
0.02662118896842003,
0.02169891819357872,
-0.010789284482598305,
-0.0005013286136090755,
0.0016171891475096345,
-0.0008717777673155069,
0.015272282995283604,
-0.008328148163855076,
-0.007654193788766861,
-0.0021452202927321196,
-0.02563432790338993,
0.004350614733994007,
0.002734930021688342,
0.008340182714164257,
0.018016239628195763,
-0.014429840259253979,
0.00598134333267808,
-0.03068898431956768,
0.027006305754184723,
-0.000049408889026381075,
-0.01989368349313736,
0.003438971471041441,
-0.033457010984420776,
0.009561724960803986,
0.015777748078107834,
-0.006619192659854889,
0.04652690887451172,
0.04166480898857117,
-0.006414599716663361,
-0.029726192355155945,
0.03227759152650833,
0.009688091464340687,
-0.009272887371480465,
0.014947340823709965,
-0.024418802931904793,
-0.03499747812747955,
0.015200073830783367,
-0.00044867597171105444,
-0.010650882497429848,
-0.01551298052072525,
0.010422219522297382,
0.004934307187795639,
-0.010151434689760208,
-0.029389215633273125,
-0.01820879802107811,
-0.022300662472844124,
-0.0204713586717844,
-0.006751576438546181,
-0.061426110565662384,
-0.044697605073451996,
-0.0011320323683321476,
0.011415098793804646,
-0.015103794634342194,
-0.02012234553694725,
-0.02628421224653721,
0.017931994050741196,
0.03988364338874817,
-0.030039099976420403,
-0.03648980334401131,
0.0359843373298645,
0.023347698152065277,
-0.02722293511033058,
-0.0192317645996809,
0.018858682364225388,
0.010999894700944424,
-0.01988164894282818,
-0.03959480673074722,
0.01068698801100254,
0.003959480673074722,
0.029726192355155945,
-0.014285421930253506,
0.021434148773550987,
0.022059964016079903,
-0.00018155768339056522,
0.016836820170283318,
0.011487307958304882,
-0.006643262691795826,
0.037043411284685135,
0.011734023690223694,
-0.013791990466415882,
-0.028715262189507484,
-0.015922166407108307,
-0.012113123200833797,
0.009700126014649868,
0.01136094145476818,
-0.001769129652529955,
-0.002954566851258278,
0.008629020303487778,
0.033336661756038666,
0.0012222941732034087,
-0.016475772485136986,
0.035141896456480026,
0.023311592638492584,
-0.003526224521920085,
-0.01563332974910736,
-0.000007944911885715555,
-0.0038782451301813126,
-0.021638743579387665,
-0.010879545472562313,
0.000013515752470993903,
-0.010265766642987728,
0.011216523125767708,
0.011950652115046978,
0.0012410986237227917,
0.01349111832678318,
-0.007088553626090288,
0.008111519739031792,
0.01056663878262043,
-0.030303867533802986,
0.01562129519879818,
-0.03285526484251022,
0.006992274429649115,
-0.023119034245610237,
-0.031772125512361526,
-0.0014411788433790207,
-0.03810248151421547,
-0.032109104096889496,
0.030833402648568153,
-0.007967101410031319,
-0.00368267809972167,
-0.018148623406887054,
-0.008629020303487778,
-0.040076203644275665,
0.008292043581604958,
-0.04438469558954239,
-0.0008003205875866115,
-0.00095903075998649,
0.002420518547296524,
-0.03620096668601036,
-0.007299164310097694,
0.006667332258075476,
0.003198273479938507,
-0.03733224794268608,
-0.026260143145918846,
0.0025724589359015226,
-0.009128468111157417,
0.022733919322490692,
0.03831910714507103,
-0.027030376717448235,
0.005123856943100691,
-0.018401356413960457,
0.0009966398356482387,
-0.006008422002196312,
0.023684674873948097,
0.0034510064870119095,
-0.032542359083890915,
-0.0019060266204178333,
-0.013009722344577312,
0.003234378295019269,
-0.03639352694153786,
-0.013575362972915173,
-0.005364554934203625,
-0.02338380366563797,
-0.0026612163055688143,
-0.024033688008785248,
-0.0017646165797486901,
-0.0005855729104951024,
0.013527222909033298,
-0.03694713115692139,
-0.021638743579387665,
0.006643262691795826,
0.017847750335931778,
0.0001498720666859299,
0.041761089116334915,
-0.03494933620095253,
0.00938721839338541,
-0.00491625489667058,
0.04055760055780411,
-0.01743856444954872,
-0.00750375771895051,
0.03831910714507103,
0.00005255864743958227,
0.0016502850921824574,
-0.002056462923064828,
0.0002619470178615302,
-0.03403468430042267,
-0.0017706340877339244,
-0.02070002071559429,
-0.003147125244140625,
0.0043445974588394165,
-0.011294749565422535,
0.030255727469921112,
-0.010885563679039478,
0.008725299499928951,
-0.009742247872054577,
0.00012730663002002984,
-0.006167883984744549,
0.010494429618120193,
-0.0238411296159029,
-0.03641759604215622,
0.001979740336537361,
-0.021265661343932152,
-0.042868297547101974,
0.002294152043759823,
0.018834611400961876,
-0.01027780119329691,
0.042916439473629,
-0.008990067057311535,
-0.008165677078068256,
0.02775247022509575,
-0.026910027489066124,
-0.017053447663784027,
0.020399149507284164,
0.010650882497429848,
0.00012787076411768794,
0.02148228883743286,
0.004865106660872698,
0.0007882856880314648,
0.0032765003852546215,
0.03855980560183525,
-0.01776350662112236,
-0.005864003207534552,
-0.04161667078733444,
0.01785978488624096,
-0.012347803451120853,
-0.014189142733812332,
0.1242964044213295,
-0.012985652312636375,
0.01269681565463543,
0.010536551475524902,
-0.012612571008503437,
-0.014165072701871395,
0.0011576066026464105,
0.00534349400550127,
-0.010656900703907013,
-0.011812250129878521,
0.0101093128323555,
0.029870612546801567,
0.04245911166071892,
0.04919865354895592,
0.01456222403794527,
-0.012913443148136139,
0.002737938892096281,
0.04284422844648361,
-0.020880544558167458,
-0.01415303722023964,
-0.0019075310556218028,
0.03396247699856758,
-0.010151434689760208,
0.026717469096183777,
-0.011378994211554527,
-0.0014201176818460226,
-0.011529430747032166,
-0.006643262691795826,
-0.01398454885929823,
-0.02630828320980072,
-0.0014103393768891692,
0.012034895829856396,
0.015127863734960556,
-0.010506464168429375,
0.0020654890686273575,
-0.003255439456552267,
-0.015910131856799126,
-0.01977333426475525,
0.017378389835357666,
0.008370270021259785,
-0.004245309624820948,
0.011721988208591938,
0.01303379237651825,
-0.013298559933900833,
0.033986546099185944,
0.004952359478920698,
-0.030063170939683914,
-0.02167484723031521,
0.005626313854008913,
-0.01349111832678318,
0.003613477572798729,
-0.0012049939250573516,
0.024334559217095375,
-0.0017435555346310139,
-0.03810248151421547,
-0.033793989568948746,
0.022312697023153305,
0.01617489941418171,
-0.02156653441488743,
-0.024539152160286903,
0.006065587513148785,
0.003872227855026722,
0.010079225525259972,
-0.00044002587674185634,
0.01456222403794527
] | 2024-07-18 | 51 | 39024031 | [
"multiple myeloma cells",
"regulatory T cells",
"multiple myeloma",
"multiple myeloma microenvironment dynamics",
"BCMA CAR-T cell therapy",
"CD8+ effector CAR-T cells",
"Cell-cell communication network analysis",
"enhanced CD8+ effector T-cell cytotoxic activity",
"MIF pathway-mediated anti-multiple myeloma immunity",
"elevated type 1 conventional dendritic cell",
"CAR-T cell infusion",
"BCMA CAR-T therapy",
"cytotoxic activity",
"paired bone marrow specimens",
"B-cell maturation antigen",
"attenuated immunosuppression",
"the multiple myeloma microenvironment",
"single-cell RNA",
"gene expression profiles",
"BCMA",
"DC re",
"favorable responses",
"patients",
"day",
"MIF pathway",
"-clustering inferred intramedullary-originated type 3 conventional DCs",
"DC",
"treatment responsivity",
"CAR-T",
"extramedullary migration"
] | [] | 0 | 10.1158/1078-0432.CCR-24-0352 | [
"Yang",
"Qin",
"Yang",
"Wang",
"Feng",
"Zhang",
"Zheng",
"Li",
"Xiang",
"Ning",
"Xu",
"Zuo",
"Zhang",
"Yun",
"Zhou",
"Wang",
"He",
"Shang",
"Sun",
"Liu"
] | [
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Beijing, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Beijing, China.",
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Beijing, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Beijing, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Beijing, China.",
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Beijing, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Beijing, China.\nDepartment of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Beijing, China.\nDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.",
"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Beijing, China.\nDepartment of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China.",
"Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China."
] | [
"39024031",
"28726797",
"33516340",
"32978608",
"34048683",
"34175021",
"33512480",
"25510276",
"33633361",
"19786984",
"30948292",
"17005292",
"38407266",
"31178118",
"30954475",
"30289549",
"34914499",
"27614798",
"22455463",
"33462507",
"28825705",
"33597522",
"36026513",
"27511158",
"27531699",
"34320168",
"27030077",
"11988758",
"29246166",
"30158425",
"33020644",
"35318469",
"35361683",
"28226228",
"33526920",
"31467405",
"19286519",
"28963110",
"35363544",
"23465663",
"19594640",
"34171432",
"11756671",
"33117743",
"33435306",
"33180899",
"37055515",
"37506694",
"36898378",
"30896447",
"28212749"
] | [] | 5.077995 | 5.744003 |
39021098 | 714 | CAR-T cell technologies that interact with the tumour microenvironment in solid tumours. | Chimeric antigen receptor (CAR) T-cells have emerged as a ground-breaking therapy for the treatment of hematological malignancies due to their capacity for rapid tumor-specific killing and long-lasting tumor immunity. However, the same success has not been observed in patients with solid tumors. Largely, this is due to the additional challenges imposed by safe and uniform target selection, inefficient CAR T-cell access to sites of disease and the presence of a hostile immunosuppressive tumor microenvironment.
Literature was reviewed on the PubMed database from the first description of a CAR by Kuwana, Kurosawa and colleagues in December 1987 through to the present day. This literature indicates that in order to tackle solid tumors, CAR T-cells can be further engineered with additional armoring strategies that facilitate trafficking to and infiltration of malignant lesions together with reversal of suppressive immune checkpoints that operate within solid tumor lesions.
In this review, we describe a number of recent advances in CAR T-cell technology that set out to combat the problems imposed by solid tumors including tumor recruitment, infiltration, immunosuppression, metabolic compromise, and hypoxia. | [
0.021608415991067886,
0.017723755910992622,
0.049575649201869965,
0.0626632496714592,
-0.0020651703234761953,
-0.02262582629919052,
-0.016821959987282753,
0.019145820289850235,
0.016683222725987434,
0.0046274843625724316,
-0.03089228831231594,
-0.03775981068611145,
-0.051841698586940765,
0.00600041076540947,
0.01689133048057556,
-0.04245377331972122,
0.046037834137678146,
0.003997383639216423,
0.03255714103579521,
0.009093107655644417,
0.030106106773018837,
-0.0051622032187879086,
0.0028802549932152033,
-0.017388474196195602,
-0.04065018147230148,
-0.005196887534111738,
-0.003193860175088048,
0.006324132438749075,
-0.03482319414615631,
-0.02216336689889431,
0.012185805477201939,
-0.013284146785736084,
-0.030244845896959305,
-0.011168394237756729,
0.001599820563569665,
0.05295160040259361,
0.012070190161466599,
0.01551551278680563,
-0.0294586643576622,
-0.01185052189975977,
0.05045432224869728,
0.013064478524029255,
0.01146321278065443,
0.09355553984642029,
-0.06936891376972198,
0.008595963940024376,
0.0060408757999539375,
-0.05507891625165939,
0.0036707716062664986,
-0.006763468962162733,
-0.0498531237244606,
-0.003607183462008834,
-0.014752455055713654,
0.010688592679798603,
-0.04552912712097168,
0.02913494221866131,
-0.030314214527606964,
0.009688524529337883,
-0.00994865782558918,
0.006405062973499298,
0.013087601400911808,
-0.010093176737427711,
-0.00044800754403695464,
-0.01666009984910488,
-0.07126499712467194,
0.006983137223869562,
-0.08148534595966339,
-0.029088696464896202,
-0.007908055558800697,
0.0434018149971962,
0.010387994349002838,
-0.015839233994483948,
0.005092834122478962,
-0.006514897104352713,
0.05771493539214134,
-0.01866023615002632,
-0.006272105500102043,
0.04809577763080597,
-0.003968479577451944,
0.0006633402081206441,
0.02779380977153778,
-0.002148990985006094,
0.007942739874124527,
-0.06973887979984283,
-0.02823314629495144,
-0.002407679334282875,
-0.0014928767923265696,
-0.04608407989144325,
-0.05369153618812561,
-0.01740003563463688,
0.010960288345813751,
0.03593309596180916,
-0.03829164057970047,
0.031377870589494705,
0.01782781071960926,
-0.004537882748991251,
-0.017353789880871773,
-0.04048832133412361,
0.0528591088950634,
0.03313521668314934,
0.03581748157739639,
-0.009792577475309372,
-0.02892683632671833,
-0.027053875848650932,
0.03306584805250168,
-0.015157107263803482,
-0.04971438646316528,
-0.01740003563463688,
0.02832563780248165,
-0.019215188920497894,
0.06280198693275452,
-0.03156285360455513,
0.010636566206812859,
0.05748370289802551,
-0.023955397307872772,
-0.04176008328795433,
0.0016056012827903032,
0.002753078704699874,
0.004587019328027964,
0.0354706346988678,
-0.030337337404489517,
0.03406013548374176,
0.02659141644835472,
-0.05873234570026398,
0.02996736951172352,
-0.024602839723229408,
0.09526664018630981,
-0.03769044205546379,
-0.028510622680187225,
-0.05443147197365761,
0.02959740161895752,
0.00293661723844707,
-0.00191198056563735,
-0.009752112440764904,
-0.06321819871664047,
0.006029314361512661,
-0.03782917931675911,
-0.012948863208293915,
-0.013469129800796509,
-0.024279119446873665,
0.015399898402392864,
-0.024140380322933197,
-0.02409413456916809,
-0.022336788475513458,
-0.0177584420889616,
-0.036673031747341156,
-0.009110450744628906,
0.026822645217180252,
-0.008237558417022228,
0.04159822314977646,
-0.01703006774187088,
0.04883571341633797,
0.07413224130868912,
-0.0015882590087130666,
-0.005393432918936014,
-0.04539038985967636,
-0.00022526831889990717,
0.058547358959913254,
-0.036349307745695114,
-0.04925192520022392,
-0.009902412071824074,
0.009451514109969139,
-0.021747153252363205,
-0.01733066700398922,
0.020845357328653336,
-0.03142411634325981,
-0.0186949223279953,
0.00696579460054636,
-0.06169208511710167,
-0.008214435540139675,
-0.024255996569991112,
-0.060212213546037674,
-0.05822363868355751,
-0.021284693852066994,
-0.037806056439876556,
0.012602019123733044,
0.025389021262526512,
0.02469533309340477,
-0.024556593969464302,
-0.020683497190475464,
0.018648674711585045,
0.03408325836062431,
0.009925534948706627,
-0.0003668965073302388,
-0.02319233864545822,
0.0177584420889616,
-0.006006191484630108,
0.03493880853056908,
-0.035216283053159714,
-0.028140654787421227,
0.003769044065847993,
0.010682811960577965,
0.03491568565368652,
0.016347939148545265,
0.007838686928153038,
-0.018810536712408066,
0.0027718660421669483,
0.021619977429509163,
-0.003991602919995785,
-0.023747291415929794,
0.028117531910538673,
-0.017978109419345856,
-0.05258163437247276,
0.02272987924516201,
-0.014220627024769783,
-0.02140030823647976,
-0.03012922964990139,
0.04892820492386818,
-0.009960219264030457,
0.01570049673318863,
0.04291623458266258,
-0.00836473423987627,
0.007144997827708721,
-0.0037343597505241632,
-0.03262650966644287,
-0.029088696464896202,
-0.024741578847169876,
0.04280061647295952,
0.005011903587728739,
0.006387720350176096,
-0.02370104379951954,
-0.0008938473183661699,
-0.007000479381531477,
0.019573593512177467,
-0.038522869348526,
0.02049851231276989,
0.030106106773018837,
-0.035077545791864395,
0.005089943762868643,
-0.025111544877290726,
0.0011518129613250494,
0.0034742262214422226,
0.011399623937904835,
-0.015318967401981354,
-0.05808490142226219,
-0.04347118362784386,
0.023157654330134392,
0.011451651342213154,
0.04550600424408913,
-0.019608279690146446,
-0.0034713358618319035,
0.01726129651069641,
0.011445870622992516,
-0.021504363045096397,
-0.021550608798861504,
0.012925740331411362,
-0.007827125489711761,
-0.06997010856866837,
0.008468788117170334,
-0.0222674198448658,
0.011555704288184643,
0.004355789627879858,
0.00596572645008564,
0.014972123317420483,
0.0430549718439579,
0.021250009536743164,
0.032649632543325424,
-0.043078094720840454,
0.02876497432589531,
-0.026522047817707062,
-0.01959671825170517,
0.017504088580608368,
-0.02253333479166031,
-0.06668664515018463,
-0.05036183074116707,
-0.023146092891693115,
-0.0074687195010483265,
0.0018324954435229301,
0.05785367265343666,
-0.013630990870296955,
0.049945615231990814,
0.015133984386920929,
0.053275324404239655,
-0.018879905343055725,
-0.06368066370487213,
0.024579716846346855,
-0.014463418163359165,
0.028441254049539566,
0.022845495492219925,
0.01779312640428543,
0.00826646201312542,
0.04155197739601135,
0.011151052080094814,
-0.01626700907945633,
-0.00485004298388958,
-0.007029382977634668,
-0.022417720407247543,
0.00429220125079155,
0.0054628015495836735,
-0.007301077712327242,
0.02159685455262661,
0.0036389774177223444,
-0.020822234451770782,
-0.013561622239649296,
-0.003777715377509594,
-0.0017457843059673905,
-0.021215325221419334,
-0.017122559249401093,
-0.02559712901711464,
0.009335899725556374,
-0.012671387754380703,
0.014590593986213207,
-0.008994835428893566,
-0.044211119413375854,
0.03692738339304924,
0.024071011692285538,
0.009052642621099949,
-0.03630306199193001,
0.044673576951026917,
0.043979890644550323,
0.030244845896959305,
-0.0320715606212616,
0.021955261006951332,
0.019261434674263,
-0.005855892319232225,
0.01559644378721714,
0.03523940593004227,
-0.06460557878017426,
0.012208928354084492,
-0.05771493539214134,
-0.027678195387125015,
-0.017608141526579857,
-0.04189882054924965,
0.02296110987663269,
0.008249119855463505,
-0.033204585313797,
0.020151669159531593,
-0.011457432061433792,
0.03803728520870209,
-0.05091677978634834,
0.010035369545221329,
-0.06853648275136948,
0.053136587142944336,
-0.02205931395292282,
0.0015839234692975879,
-0.015457705594599247,
-0.017781564965844154,
-0.04460420832037926,
0.019377049058675766,
0.022013068199157715,
0.00026175923994742334,
0.029944246634840965,
-0.06474431604146957,
0.07639829069375992,
0.004185257479548454,
-0.02336576208472252,
0.009688524529337883,
0.03158597648143768,
-0.011260886676609516,
-0.004202599637210369,
0.01906488835811615,
0.02316921576857567,
0.006468650884926319,
0.024880316108465195,
-0.02366635948419571,
0.024556593969464302,
-0.041783206164836884,
-0.027238858863711357,
0.020614128559827805,
-0.011480554938316345,
0.019481102004647255,
0.019538909196853638,
-0.04696275293827057,
0.024810947477817535,
0.045575372874736786,
0.047147735953330994,
-0.020417582243680954,
0.04321683198213577,
-0.03230278939008713,
-0.027146367356181145,
-0.024417856708168983,
0.012278296984732151,
0.03103102557361126,
-0.011977698653936386,
-0.037875425070524216,
0.03440697863698006,
0.01461371686309576,
0.012220489792525768,
0.0014777022879570723,
-0.013087601400911808,
0.009659620933234692,
-0.000199616260943003,
-0.01593172736465931,
-0.021088149398565292,
-0.016347939148545265,
0.020544759929180145,
0.03267275542020798,
0.002121532568708062,
-0.0709875151515007,
0.002030485775321722,
-0.019920438528060913,
-0.006902206689119339,
0.004896288737654686,
0.007838686928153038,
-0.0069889179430902,
0.055772602558135986,
-0.01986263133585453,
0.06839774549007416,
0.04139011725783348,
0.006318351719528437,
0.00659004645422101,
-0.03752858191728592,
0.018186215311288834,
-0.02103034220635891,
0.029250556603074074,
-0.028880590572953224,
0.04543663561344147,
0.013769729062914848,
0.011838960461318493,
-0.026082711294293404,
-0.003338378854095936,
-0.00854971818625927,
0.024510348215699196,
0.009069984778761864,
-0.009601813741028309,
-0.0198279470205307,
-0.02145811729133129,
0.035308774560689926,
-0.02316921576857567,
0.022868618369102478,
0.037042997777462006,
-0.021169079467654228,
0.01242859661579132,
-0.011613511480391026,
-0.0017978108953684568,
-0.0018772961338981986,
0.04092765599489212,
0.0071103135123848915,
0.0032516676001250744,
-0.06483680754899979,
-0.03295023366808891,
0.04046519845724106,
0.002105635590851307,
-0.010411117225885391,
-0.02506529912352562,
0.041413240134716034,
-0.018822098150849342,
0.023955397307872772,
-0.03956340253353119,
0.02996736951172352,
-0.05003810673952103,
0.0003912840038537979,
0.0388697125017643,
0.0007594450726173818,
0.03385202959179878,
-0.01063078548759222,
0.02703075297176838,
0.04162134602665901,
-0.03505442291498184,
-0.02696138247847557,
-0.013619429431855679,
-0.045413512736558914,
-0.0011554259108379483,
0.012544211000204086,
-0.03829164057970047,
0.022880179807543755,
0.02536589838564396,
-0.07195868343114853,
-0.007220147643238306,
0.038476623594760895,
0.04312434047460556,
-0.03382890671491623,
0.021007219329476357,
-0.06622418761253357,
0.009179819375276566,
0.020683497190475464,
0.04626906290650368,
-0.010844673030078411,
0.008474568836390972,
-0.040141478180885315,
0.02149280160665512,
-0.00815084669739008,
-0.017180366441607475,
-0.00836473423987627,
-0.02476470172405243,
0.04090453311800957,
-0.008069916628301144,
0.002624457236379385,
0.024279119446873665,
0.017712194472551346,
-0.021007219329476357,
-0.014671524986624718,
-0.01952734775841236,
0.004517650231719017,
0.05295160040259361,
0.007619018666446209,
-0.04370241239666939,
0.010422678664326668,
-0.03165534511208534,
0.037782933562994,
-0.02326170727610588,
0.002913494361564517,
0.010960288345813751,
-0.009937096387147903,
-0.0252965297549963,
-0.027655072510242462,
-0.013110724277794361,
-0.013087601400911808,
-0.027354473248124123,
0.02432536520063877,
-0.008393637835979462,
0.013573183678090572,
0.009058423340320587,
0.018405884504318237,
0.03595621883869171,
0.014937439002096653,
-0.009919754229485989,
0.08222528547048569,
0.027655072510242462,
0.02232522703707218,
-0.0335976742208004,
-0.022776124998927116,
0.04613032564520836,
0.004373131785541773,
-0.030476074665784836,
-0.019272996112704277,
-0.0422687903046608,
-0.00830114632844925,
-0.007035163696855307,
-0.010249256156384945,
-0.0016850864049047232,
-0.004662168677896261,
-0.006659415550529957,
0.008885001763701439,
0.020706620067358017,
-0.027377596125006676,
-0.02193213813006878,
-0.03260338678956032,
-0.007081409450620413,
-0.005705593153834343,
-0.007289516273885965,
-0.02159685455262661,
0.016451993957161903,
0.020706620067358017,
-0.00930121447890997,
-0.029782386496663094,
-0.04173696041107178,
0.0264295544475317,
-0.015214914456009865,
-0.048604484647512436,
-0.015284283086657524,
-0.012787002138793468,
0.025481512770056725,
-0.01556175947189331,
-0.003728579031303525,
0.011977698653936386,
-0.001885967212729156,
-0.03066105954349041,
0.030082983896136284,
-0.030938534066081047,
0.016220763325691223,
-0.032719001173973083,
0.009405268356204033,
-0.007295296993106604,
0.025943972170352936,
-0.025481512770056725,
-0.021839644759893417,
-0.030753551051020622,
-0.004537882748991251,
-0.03655741736292839,
-0.02232522703707218,
0.0004357234574854374,
0.014775577932596207,
-0.009411049075424671,
-0.0301986001431942,
0.031747836619615555,
-0.018475253134965897,
-0.024279119446873665,
-0.02483407035470009,
0.007347323931753635,
-0.011006534099578857,
-0.021307816728949547,
-0.002180785173550248,
-0.006734564900398254,
0.04423424229025841,
0.00015129287203308195,
-0.01703006774187088,
0.01009895745664835,
0.009341680444777012,
0.029713016003370285,
-0.0298286322504282,
-0.01576986536383629,
-0.021654661744832993,
0.05091677978634834,
-0.0008100265404209495,
0.02543526701629162,
-0.042037561535835266,
-0.007584334351122379,
-0.004847152624279261,
-0.0054425690323114395,
0.03459196537733078,
0.007988986559212208,
0.038638483732938766,
0.00634147459641099,
-0.046176571398973465,
0.026383308693766594,
0.0024625963997095823,
-0.015573320910334587,
0.01185052189975977,
-0.021781837567687035,
-0.008202874101698399,
-0.01016254536807537,
0.011330255307257175,
-0.045205406844615936,
-0.027446966618299484,
0.03491568565368652,
0.01555019710212946,
-0.043378692120313644,
0.00789649412035942,
0.007804002612829208,
0.036973629146814346,
0.04502042382955551,
-0.03489256277680397,
0.021111272275447845,
0.03110039420425892,
0.01959671825170517,
-0.018706483766436577,
-0.010278160683810711,
-0.007780879735946655,
-0.028186900541186333,
-0.017723755910992622,
-0.02832563780248165,
-0.0301986001431942,
0.00934746116399765,
-0.003387515200302005,
-0.04007210582494736,
-0.026915136724710464,
0.003821070771664381,
0.01544614415615797,
-0.00021424876467790455,
-0.006196956150233746,
-0.039239682257175446,
-0.0008028006413951516,
0.026637662202119827,
0.006168052554130554,
-0.030984779819846153,
0.005821208003908396,
-0.03449947014451027,
0.0034944589715451,
-0.003318146336823702,
-0.00004265555617166683,
0.0027285104151815176,
-0.007301077712327242,
-0.006994698662310839,
0.015157107263803482,
-0.021550608798861504,
-0.02012854628264904,
0.004948315676301718,
-0.0070120408199727535,
-0.005601539742201567,
-0.002180785173550248,
-0.022903302684426308,
0.01835963875055313,
-0.035909973084926605,
0.00938214547932148,
-0.0038933302275836468,
0.024117257446050644,
-0.02099565789103508,
0.039979614317417145,
0.07464094460010529,
-0.04180632904171944,
0.005364529322832823,
-0.014740893617272377,
-0.010925603099167347,
-0.021874329075217247,
-0.010740620084106922,
0.012382350862026215,
0.005263366270810366,
0.02086848020553589,
0.0042257229797542095,
0.06677913665771484,
0.014509663917124271,
0.0004667949688155204,
-0.022984232753515244,
0.00016980931104626507,
0.027146367356181145,
0.018706483766436577,
0.0074687195010483265,
-0.03329707682132721,
0.003173627657815814,
-0.017712194472551346,
0.004378912504762411,
-0.016810398548841476,
-0.053044095635414124,
-0.005679579451680183,
0.0034193091560155153,
0.009463075548410416,
0.027377596125006676,
0.017770003527402878,
-0.011220421642065048,
0.01589704118669033,
-0.01045158226042986,
-0.03972526267170906,
-0.008023670874536037,
0.014602155424654484,
0.016972260549664497,
-0.00830114632844925,
-0.019018642604351044,
-0.004462733399122953,
-0.03648804873228073,
0.01866023615002632,
0.016347939148545265,
0.030568566173315048,
-0.04333244636654854,
0.044211119413375854,
-0.007538088131695986,
0.01200082153081894,
-0.03140099346637726,
0.00045125922770239413,
0.040280215442180634,
0.009919754229485989,
0.0077288527972996235,
-0.012255174107849598,
-0.01609358750283718,
0.014775577932596207,
-0.0069542331621050835,
0.0011539807310327888,
0.03849974647164345,
-0.0008085813606157899,
0.03637243062257767,
0.002027595415711403,
0.019215188920497894,
-0.021978383883833885,
0.005243133287876844,
0.03970213979482651,
0.030637934803962708,
-0.0415288545191288,
0.04633843153715134,
-0.022047752514481544,
-0.004055190831422806,
-0.0017024286789819598,
-0.021770276129245758,
-0.024186626076698303,
-0.0011590388603508472,
-0.019585154950618744,
0.012914178892970085,
-0.023643236607313156,
-0.02232522703707218,
-0.002815221669152379,
0.001504438230767846,
0.013677236624062061,
-0.023770414292812347,
-0.011203079484403133,
0.0003432316007092595,
-0.000926363980397582,
0.013630990870296955,
0.023770414292812347,
-0.005092834122478962,
0.002190901432186365,
-0.02266051061451435,
0.006838618312031031,
0.007277954835444689,
0.009902412071824074,
-0.012220489792525768,
0.011943014338612556,
-0.033343322575092316,
0.0026259024161845446,
0.015492389909923077,
-0.01257889624685049,
-0.02083379589021206,
-0.02506529912352562,
-0.0006250427686609328,
0.00028036601725034416,
0.0047662220895290375,
0.007624799385666847,
0.018775852397084236,
0.025019053369760513,
0.0160357803106308,
-0.0009386480669490993,
0.0019582265522331,
-0.008688456378877163,
-0.021943699568510056,
0.005078382324427366,
-0.02453347109258175,
-0.019307680428028107,
0.018741168081760406,
-0.025412144139409065,
0.010867795906960964,
-0.013654113747179508,
0.03295023366808891,
-0.010804207995533943,
0.01117995660752058,
0.004838481545448303,
0.003702565561980009,
-0.0041679153218865395,
-0.004032067954540253,
0.005948384292423725,
0.023620113730430603,
-0.034245118498802185,
-0.0071739014238119125,
-0.008902343921363354,
0.02673015370965004,
-0.020336652174592018,
0.02289174124598503,
-0.017215050756931305,
0.03815289959311485,
0.045575372874736786,
-0.08976337313652039,
-0.03262650966644287,
0.0114285284653306,
-0.01494900044053793,
-0.0008866214193403721,
0.006821276154369116,
-0.017608141526579857,
-0.0058790151961147785,
0.02568962052464485,
-0.035146914422512054,
0.010896699503064156,
-0.03241840377449989,
0.0056593469344079494,
0.006780811119824648,
-0.0006564756040461361,
-0.026452677324414253,
-0.028348760679364204,
-0.050408076494932175,
-0.026822645217180252,
0.02552775852382183,
0.014555909670889378,
-0.0013476356398314238,
-0.012787002138793468,
0.07408599555492401,
-0.009272310882806778,
0.033412691205739975,
-0.015388336963951588,
-0.023088285699486732,
-0.05503267049789429,
-0.04529789835214615,
-0.012382350862026215,
0.03762107342481613,
-0.04243065044283867,
0.0419219434261322,
-0.014463418163359165,
-0.04495105519890785,
0.03459196537733078,
-0.025620251893997192,
-0.0198279470205307,
0.01028394140303135,
-0.00014686699432786554,
0.01085045374929905,
0.02179339900612831,
0.010821550153195858,
0.002592663047835231,
-0.022475527599453926,
-0.02936617285013199,
0.006618950050324202,
-0.005670908372849226,
-0.005630443338304758,
0.0043095434084534645,
-0.040673304349184036,
-0.03759795054793358,
-0.0014068882446736097,
0.00547436298802495,
-0.011729126796126366,
-0.006260544061660767,
0.026822645217180252,
0.026683907955884933,
-0.003387515200302005,
-0.04055768996477127,
0.07237489521503448,
0.039147187024354935,
-0.0049858903512358665,
-0.009572910144925117,
-0.0024727126583456993,
-0.026383308693766594,
0.02186276763677597,
-0.029643647372722626,
0.02009386196732521,
-0.008538156747817993,
0.01242859661579132,
-0.03729734942317009,
0.03193282335996628,
0.009590252302587032,
0.004688182380050421,
-0.01909957267343998,
0.009364803321659565,
0.0028701387345790863,
-0.00023357813188340515,
0.010052711702883244,
-0.012243612669408321,
-0.02476470172405243,
0.0054974863305687904,
-0.03958652541041374,
-0.012775440700352192,
-0.0007211476331576705,
0.01883365958929062,
0.007538088131695986,
-0.005188216455280781,
-0.012625142000615597,
-0.016914453357458115,
0.009208722971379757,
0.004338447470217943,
-0.011619292199611664,
-0.037343598902225494,
0.004318214487284422,
-0.0010419788304716349,
0.014648402109742165,
-0.018290270119905472,
0.044581085443496704,
-0.031216010451316833,
0.002832563826814294,
-0.01351537648588419,
-0.04275437071919441,
-0.0023007355630397797,
0.04229191318154335,
0.012844810262322426,
0.008630648255348206,
-0.02159685455262661,
0.02352762222290039,
0.007422473281621933,
0.018810536712408066,
-0.007578553631901741,
-0.006110244896262884,
0.014844946563243866,
0.015423021279275417,
-0.02506529912352562,
0.008272242732346058,
-0.012289858423173428,
0.04025709256529808,
-0.005167983938008547,
0.0073126391507685184,
-0.018151530995965004,
-0.003887549275532365,
-0.02182808332145214,
0.0027285104151815176,
0.017319105565547943,
0.000883731001522392,
0.0027328459545969963,
0.027655072510242462,
0.02152748592197895,
0.0024192407727241516,
0.013076039962470531,
0.0022530443966388702,
0.03630306199193001,
0.0068906452506780624,
0.03195594623684883,
0.013018231838941574,
0.024348488077521324,
-0.0029684114269912243,
-0.019053326919674873,
-0.016105148941278458,
-0.005824098363518715,
0.042037561535835266,
-0.025389021262526512,
-0.03519316017627716,
-0.007139217108488083,
0.009694305248558521,
-0.00416502496227622,
-0.053645290434360504,
0.001268150401301682,
0.05859360843896866,
0.0657154843211174,
0.005483034532517195,
0.007613237947225571,
-0.008434103801846504,
-0.010156764648854733,
-0.01609358750283718,
0.03789854794740677,
-0.03701987490057945,
0.0604434460401535,
-0.030452951788902283,
-0.00569114089012146,
0.021770276129245758,
0.001981349429115653,
-0.014498102478682995,
-0.0033499402925372124,
0.04483544081449509,
0.00001953258652065415,
0.009468856267631054,
-0.0373898446559906,
0.02432536520063877,
0.0009661065996624529,
-0.0078329062089324,
0.034707579761743546,
0.010786865837872028,
-0.008156627416610718,
0.038083530962467194,
0.028834344819188118,
-0.034638211131095886,
-0.013677236624062061,
0.012185805477201939,
0.03843037784099579,
0.008006328716874123,
-0.006613169331103563,
-0.005136189982295036,
-0.02126157097518444,
0.009590252302587032,
0.006642073392868042,
-0.017504088580608368,
-0.031054148450493813,
0.01756189577281475,
0.0388697125017643,
0.025481512770056725,
-0.018879905343055725,
-0.023516060784459114,
0.0061391484923660755,
-0.036673031747341156,
-0.014891193248331547,
-0.031678467988967896,
0.016810398548841476,
0.04522852972149849,
-0.007486061658710241,
-0.03528565168380737,
-0.002394672716036439,
0.016856646165251732,
-0.04823451489210129,
-0.014405610039830208,
0.0471939817070961,
-0.02839500829577446,
0.01487963180989027,
-0.03748233616352081,
0.020648812875151634,
0.03290398791432381,
0.025620251893997192,
0.013596306554973125,
0.0222674198448658,
-0.033181462436914444,
-0.006220079027116299,
-0.032279666513204575,
-0.04585285112261772,
-0.03269587829709053,
-0.015399898402392864,
-0.012879494577646255,
-0.0024235763121396303,
0.05521765351295471,
0.022683633491396904,
0.0014928767923265696,
0.01002958882600069,
-0.02536589838564396,
0.01541145984083414,
0.02106502652168274,
0.015342091210186481,
0.014382487162947655,
0.013457568362355232,
-0.030036738142371178,
-0.017608141526579857,
0.020856918767094612,
-0.012278296984732151,
0.05850111320614815,
0.00934746116399765,
0.015191791579127312,
-0.06386564671993256,
-0.012162682600319386,
0.021481240168213844,
0.0559113435447216,
-0.049436911940574646,
-0.011555704288184643,
-0.0158623568713665,
-0.0065958271734416485,
0.007139217108488083,
0.03301960229873657,
0.019203627482056618,
0.04869697615504265,
0.006150709930807352,
0.0305916890501976,
0.006416624411940575,
0.026707030832767487,
0.0053240638226270676,
0.0003739417879842222,
-0.004835591185837984,
0.0011149607598781586,
-0.01257889624685049,
0.03836100921034813,
-0.006347255315631628,
-0.0034482129849493504,
-0.022487089037895203,
0.002156216884031892,
0.013781290501356125,
0.012763879261910915,
0.01959671825170517,
-0.0038586456794291735,
-0.0033354884944856167,
0.0058587826788425446,
-0.020891603082418442,
0.01609358750283718,
-0.008688456378877163,
-0.0005965003510937095,
-0.00027350138407200575,
-0.00836473423987627,
0.015076176263391972,
-0.018255585804581642,
-0.004705524537712336,
0.02145811729133129,
0.0025666498113423586,
-0.023146092891693115,
0.007301077712327242,
0.006451308727264404,
-0.04721710458397865,
-0.03239528089761734,
0.001475534518249333,
0.0053240638226270676,
-0.02543526701629162,
-0.00702360225841403,
-0.027608826756477356,
-0.004176586400717497,
-0.011440089903771877,
0.0012406918685883284,
-0.011694442480802536,
-0.0020218146964907646,
0.029204310849308968,
-0.011515239253640175,
-0.01329570822417736,
0.027146367356181145,
-0.008717359974980354,
-0.03810665383934975,
-0.0355168841779232,
0.049205679446458817,
-0.004144792445003986,
-0.03708924353122711,
0.01576986536383629,
0.02543526701629162,
-0.012104875408113003,
0.01343444548547268,
0.015885479748249054,
-0.021619977429509163,
0.012127998284995556,
0.01646355539560318,
0.02049851231276989,
-0.02485719323158264,
0.021111272275447845,
0.0080178901553154,
-0.02770131826400757,
-0.02832563780248165,
0.01649823971092701,
0.013538499362766743,
-0.007919616997241974,
-0.02809440903365612,
-0.02952803298830986,
0.008595963940024376,
-0.007763537112623453,
0.02266051061451435,
0.011110587045550346,
-0.0029221654403954744,
-0.007902274839580059,
0.004462733399122953,
0.004153463523834944,
0.002523294184356928,
0.00015400259871967137,
0.011862083338201046,
0.022521773353219032,
0.012208928354084492,
0.030915411189198494,
0.018244024366140366,
-0.010179887525737286,
-0.02366635948419571,
-0.006046656519174576,
-0.018405884504318237,
-0.012925740331411362,
0.043841153383255005,
-0.028603114187717438,
-0.03743609040975571,
0.05142548680305481,
-0.006509115919470787,
-0.02659141644835472,
0.007295296993106604,
0.0009379254770465195,
0.0074687195010483265,
0.004208380822092295,
-0.0005495318328030407,
0.01579298824071884,
0.02906557358801365,
-0.027470089495182037,
0.005246024113148451,
0.013677236624062061,
-0.013885343447327614,
-0.0015058834105730057,
-0.008827193640172482,
-0.005457020830363035,
0.022602703422307968,
0.02832563780248165,
-0.03112351894378662,
0.0032574485521763563,
0.013006670400500298,
0.023770414292812347,
0.06215454265475273,
0.01573518104851246,
-0.0007233154028654099,
0.03456883877515793,
-0.0029973150230944157,
-0.016590731218457222,
-0.025180915370583534,
-0.00624898262321949,
-0.023886028677225113,
0.0015449034981429577,
-0.022614264860749245,
-0.009324337355792522,
0.010509390383958817,
0.021041903644800186,
0.013191654346883297,
-0.01856774464249611,
0.0071507785469293594,
-0.011688661761581898,
-0.029782386496663094,
-0.0096307173371315,
-0.004899179562926292,
0.008977493271231651,
-0.030776673927903175,
0.004454062320291996,
-0.025319652631878853,
-0.032510895282030106,
0.017642825841903687,
0.0038384131621569395,
0.005931041669100523,
0.02885746769607067,
0.0177584420889616,
0.029111819341778755,
0.008804070763289928,
-0.003127381671220064,
-0.024302242323756218,
-0.002257379936054349,
-0.058408621698617935,
0.0209609717130661,
-0.015203353017568588,
-0.010590320453047752,
0.006850179750472307,
-0.023446692153811455,
-0.03806040808558464,
-0.00923184584826231,
-0.008434103801846504,
0.006445528008043766,
0.0032487772405147552,
0.017954986542463303,
0.015376775525510311,
0.024071011692285538,
0.015642689540982246,
0.007347323931753635,
-0.04273124784231186,
0.02922743372619152,
-0.0005596481496468186,
0.0030666838865727186,
0.008041013032197952,
-0.014278434216976166,
-0.043078094720840454,
0.013619429431855679,
-0.002693826099857688,
0.0017024286789819598,
-0.013064478524029255,
0.008925466798245907,
-0.00789649412035942,
-0.0007298187701962888,
0.05480143800377846,
0.010405336506664753,
0.019747016951441765,
-0.03366704657673836,
-0.011671319603919983,
0.00024459767155349255,
-0.012047067284584045,
0.03392139822244644,
0.03343581408262253,
0.0321178063750267,
-0.04726335033774376,
-0.01596641167998314,
-0.019284557551145554,
0.0036563195753842592,
-0.02432536520063877,
-0.014428733848035336,
0.00332392705604434,
-0.009792577475309372,
-0.029643647372722626,
-0.02012854628264904,
-0.0001470476418035105,
0.015989534556865692,
0.007827125489711761,
0.004610142204910517,
-0.013099162839353085,
-0.02666078507900238,
-0.016070464625954628,
-0.011873645707964897,
0.019816385582089424,
0.017272857949137688,
0.021943699568510056,
-0.019018642604351044,
0.026637662202119827,
-0.03445322439074516,
0.03889283537864685,
0.021169079467654228,
0.021643100306391716,
-0.02869560569524765,
-0.045945342630147934,
0.00503213657066226,
0.008006328716874123,
-0.004211271181702614,
0.00954978633671999,
0.03489256277680397,
-0.03352830559015274,
0.010399555787444115,
0.05535639077425003,
-0.0198279470205307,
-0.0021403199061751366,
-0.01633637771010399,
0.00615649065002799,
-0.003852864960208535,
-0.02249865047633648,
0.001971233170479536,
0.015076176263391972,
-0.013318831101059914,
0.004341337829828262,
-0.019018642604351044,
-0.02035977505147457,
0.016821959987282753,
0.011474774219095707,
-0.016683222725987434,
-0.00020557765674311668,
-0.0000014310725191535312,
-0.048280760645866394,
-0.07311483472585678,
0.009757893159985542,
0.0058587826788425446,
-0.028973082080483437,
0.009584471583366394,
-0.01563112810254097,
0.009306995198130608,
0.023377323523163795,
-0.034846317023038864,
0.002030485775321722,
0.04786454886198044,
0.01972389407455921,
0.016186079010367393,
0.014382487162947655,
0.01746940426528454,
0.03248777240514755,
-0.009243407286703587,
-0.00046462719910778105,
-0.013815974816679955,
0.019920438528060913,
0.00014198948338162154,
-0.014856508001685143,
0.02853374555706978,
0.03762107342481613,
0.011821618303656578,
0.021654661744832993,
0.009341680444777012,
-0.0024611512199044228,
0.05091677978634834,
-0.0186949223279953,
-0.010925603099167347,
0.0000620978171355091,
-0.0018426117021590471,
-0.021909015253186226,
-0.0011207414790987968,
0.03720485791563988,
-0.00578363286331296,
0.001130135147832334,
0.03049919754266739,
0.043170586228370667,
-0.029204310849308968,
-0.028371885418891907,
0.03253401815891266,
0.04626906290650368,
0.003124491311609745,
0.018521498888731003,
-0.0007323478348553181,
-0.02262582629919052,
-0.01729598268866539,
0.014035643078386784,
-0.002335420111194253,
-0.022949548438191414,
0.013457568362355232,
-0.00587323447689414,
0.008173969574272633,
0.011919891461730003,
0.00008178847201634198,
0.001307892962358892,
-0.005243133287876844,
-0.0037921671755611897,
-0.011023876257240772,
-0.006243201903998852,
0.005433897953480482,
0.0039309049025177956,
-0.0201979149132967,
-0.02235991321504116,
0.019550470635294914,
-0.025389021262526512,
0.03940154239535332,
-0.004708414897322655,
-0.0022949548438191414,
0.02756258100271225,
-0.0004245232848916203,
-0.014347802847623825,
0.0009473192039877176,
-0.01619764044880867,
0.02149280160665512,
-0.005289379507303238,
-0.03461508825421333,
-0.01066546980291605,
0.00441648717969656,
0.00419970927760005,
0.020174792036414146,
-0.0573912113904953,
0.009463075548410416,
0.024348488077521324,
0.0060755605809390545,
0.019839508458971977,
0.03623369336128235,
-0.00456678681075573,
0.00037430308293551207,
-0.031239133328199387,
0.001386655610986054,
-0.005792303942143917,
0.02453347109258175,
0.0007164507987909019,
-0.03708924353122711,
-0.0015188901452347636,
-0.002115751849487424,
0.007636360824108124,
-0.02400164306163788,
-0.02485719323158264,
0.007480280939489603,
-0.02629081718623638,
-0.01993199996650219,
0.001504438230767846,
-0.009942877106368542,
-0.0279556717723608,
0.016405748203396797,
-0.05295160040259361,
0.004734428133815527,
-0.006549581419676542,
0.007954302243888378,
0.02326170727610588,
0.027446966618299484,
-0.014070327393710613,
0.003156285500153899,
-0.013284146785736084,
0.011301351711153984,
-0.030869165435433388,
0.010804207995533943,
0.017087874934077263,
-0.018255585804581642,
-0.011116367764770985,
0.016683222725987434,
0.017041629180312157,
-0.028071286156773567,
0.004373131785541773,
-0.01582767255604267,
0.0002456815564073622,
0.008439884521067142,
-0.04423424229025841,
0.026822645217180252,
0.025805234909057617,
0.019955122843384743,
-0.0009393706568516791,
0.03706612065434456,
-0.049945615231990814,
0.007913836278021336,
-0.023018917068839073,
0.01386222057044506,
0.00662473076954484,
-0.022914864122867584,
-0.04060393571853638,
-0.0026230120565742254,
0.0267995223402977,
0.007792441174387932,
0.02719261310994625,
0.0077404142357409,
-0.005075491964817047,
0.0008425432024523616,
-0.014128134585916996,
0.005298050586134195,
-0.0020955190993845463,
-0.0027183941565454006,
-0.015272721648216248,
0.006069779861718416,
0.036349307745695114,
0.014394048601388931,
0.04800328612327576,
0.017180366441607475,
-0.0267995223402977,
-0.0005000342498533428,
-0.007237489800900221,
-0.005384761840105057,
-0.015376775525510311,
0.002592663047835231,
0.11367252469062805,
-0.00985038559883833,
-0.013723483309149742,
0.024579716846346855,
0.009613375179469585,
-0.027285104617476463,
0.007133436389267445,
0.008994835428893566,
0.02899620495736599,
-0.01124932523816824,
0.012902617454528809,
0.011873645707964897,
0.029574278742074966,
0.040280215442180634,
0.041112642735242844,
-0.005942603573203087,
0.018509937450289726,
0.05165671557188034,
-0.011792714707553387,
0.007035163696855307,
0.030707305297255516,
0.00736466608941555,
0.01686820760369301,
0.01646355539560318,
-0.039979614317417145,
-0.00506682088598609,
-0.004858714062720537,
0.0005636223941110075,
-0.0004902792279608548,
-0.011156832799315453,
0.014868070371448994,
0.02340044640004635,
0.008567060343921185,
-0.01653292402625084,
-0.0017862494569271803,
-0.03662678599357605,
-0.021469678729772568,
-0.027215735986828804,
0.00481535866856575,
0.019955122843384743,
-0.010642346926033497,
-0.00883297435939312,
-0.004884727299213409,
-0.0065553621388971806,
0.029874878004193306,
0.013688798062503338,
-0.008434103801846504,
0.012035505846142769,
0.003777715377509594,
-0.014324679970741272,
0.001790584996342659,
-0.02046382799744606,
0.01483338512480259,
-0.034314487129449844,
-0.02938929572701454,
-0.014821823686361313,
0.00394824706017971,
0.01013364177197218,
0.009376364760100842,
-0.03759795054793358,
-0.004034958314150572,
0.017376912757754326,
0.022984232753515244,
-0.008532376028597355,
0.0020752865821123123
] | 2024-07-18 | 1 | 39021098 | [
"solid tumors",
"solid tumor lesions",
"tumor recruitment",
"inefficient CAR T-cell access",
"CAR T-cell technology",
"additional armoring strategies",
"CAR T-cells",
"suppressive immune checkpoints",
"malignant lesions",
"rapid tumor-specific killing",
"a hostile immunosuppressive tumor microenvironment",
"infiltration",
"hematological malignancies",
"recent advances",
"Chimeric antigen receptor",
"metabolic compromise",
"CAR) T-cells",
"colleagues",
"first",
"Kurosawa",
"Kuwana",
"CAR",
"December",
"PubMed",
"immunosuppression",
"safe and uniform target selection",
"reversal",
"disease",
"sites",
"patients"
] | [
"Chimeric antigen receptor (CAR)",
"cancer-associated fibroblasts (CAFs)",
"chemokine receptors",
"extracellular matrix (ECM)",
"hypoxia",
"immune checkpoint proteins",
"tumor microenvironment (TME)",
"tumor vasculature"
] | 0 | 10.1080/1744666X.2024.2380894 | [
"Taylor",
"Glover",
"Maher"
] | [
"Leucid Bio Ltd, Guy's Hospital, London, UK.",
"Leucid Bio Ltd, Guy's Hospital, London, UK.",
"Leucid Bio Ltd, Guy's Hospital, London, UK.\nKing's College London, School of Cancer and Pharmaceutical Sciences, Guy's Hospital, London, UK.\nDepartment of Immunology, Eastbourne Hospital, Eastbourne, East Sussex, UK."
] | [
"39021098"
] | [] | 9.690204 | 4.829388 |
39019408 | 715 | Targeting endothelial cell anergy to improve CAR T cell therapy for solid tumors. | Chimeric antigen receptor (CAR) T cell therapy presents significant results, especially for the treatment of hematologic malignancies. However, there are limitations and challenges to be overcome to achieve similar success for the treatment of solid tumors. These challenges involve selection of the target, infiltration into the tumor microenvironment and maintenance of functionality. The tumor vasculature is a major barrier for leukocytes to enter the tumor parenchyma. Due to the exposure of the vasculature to angiogenic growth factors during tumor progression, the endothelial cells become anergic to inflammatory cytokines, resulting in reduced leukocyte adhesion molecule expression. As such adhesion molecules are a prerequisite for leukocyte extravasation, endothelial cell anergy allows tumors to escape from endogenous immunity, as well as from cellular immunotherapies such as CAR T cells. Hence, overcoming endothelial cell anergy, e.g. through the administration of angiogenesis inhibitors, is believed to restore anti-tumor immunity. Concomitantly, both endogenous immune cells as well as cellular therapeutics such as CAR T cells can permeate into the tumor parenchyma. Here, we discuss how prior or concomitant treatment with an antiangiogenic drug can improve CAR T cell therapy, to become an attractive strategy for the treatment of solid tumors. | [
0.026523998007178307,
0.023147813975811005,
0.07074537128210068,
0.045854296535253525,
-0.02667846344411373,
-0.034865155816078186,
0.007320579141378403,
-0.0007723293965682387,
-0.0032823998481035233,
0.008098425343632698,
-0.013670230284333229,
-0.004471235442906618,
-0.04486130177974701,
0.002294921549037099,
0.015126622281968594,
-0.050444141030311584,
0.058211568742990494,
0.0068792481906712055,
0.03581401705741882,
0.027494926005601883,
0.04457443952560425,
0.0258178673684597,
0.005320797674357891,
-0.0014205343322828412,
-0.04903188347816467,
-0.017609110102057457,
0.01553485356271267,
0.02533240243792534,
-0.008059808984398842,
-0.026501931250095367,
0.05375412479043007,
-0.013946061953902245,
-0.020665327087044716,
-0.029988445341587067,
-0.016009284183382988,
0.04018319398164749,
0.019782664254307747,
-0.006095885299146175,
-0.020477762445807457,
-0.021978287026286125,
0.055607713758945465,
0.047840286046266556,
0.0034065241925418377,
0.09312085807323456,
-0.05768197029829025,
0.007166113238781691,
-0.0028934767469763756,
-0.06770018488168716,
-0.0028410686645656824,
-0.02241961844265461,
-0.010476096533238888,
0.013173731975257397,
-0.0007454357692040503,
0.017002278938889503,
-0.054989852011203766,
0.03336462751030922,
-0.023986343294382095,
-0.006145535036921501,
-0.016218917444348335,
0.011772505939006805,
-0.014519792050123215,
-0.03184203803539276,
0.011971104890108109,
-0.024207009002566338,
-0.049826279282569885,
0.0027390108443796635,
-0.02906165085732937,
-0.049252547323703766,
-0.012026271782815456,
0.003158275503665209,
0.0024024960584938526,
-0.03625534847378731,
-0.01706847921013832,
0.021349390968680382,
0.01666024699807167,
0.0163954496383667,
0.004832575097680092,
0.016737481579184532,
-0.021636255085468292,
0.005654554348438978,
0.04541296511888504,
-0.016594048589468002,
0.021338356658816338,
-0.0649639368057251,
-0.029171982780098915,
-0.023059548810124397,
-0.010360246524214745,
-0.02211068570613861,
-0.05485745146870613,
-0.017940107733011246,
-0.008578372187912464,
0.01627408340573311,
-0.03885919973254204,
0.025464802980422974,
0.007717777043581009,
0.04678109288215637,
-0.026325399056077003,
-0.08292610943317413,
0.03312189504504204,
0.03358529508113861,
0.05777023732662201,
-0.005731787066906691,
-0.04203678295016289,
-0.032614365220069885,
0.04360350966453552,
-0.012688267976045609,
-0.03764554113149643,
-0.025155870243906975,
0.03998459503054619,
-0.003952671308070421,
0.0661996603012085,
-0.030562177300453186,
0.014166727662086487,
0.0458984300494194,
-0.0175208430737257,
-0.0649639368057251,
-0.03449002280831337,
0.0272521935403347,
-0.00775087671354413,
0.04172785207629204,
0.0060738190077245235,
0.0387268029153347,
0.02475867234170437,
-0.02301541529595852,
0.014685290865600109,
-0.033188097178936005,
0.09276778995990753,
-0.020477762445807457,
-0.03281296417117119,
-0.03283503279089928,
0.040668658912181854,
0.009604467079043388,
0.011320142075419426,
-0.015876885503530502,
-0.0688476487994194,
0.006128985434770584,
-0.02504553832113743,
0.008313573896884918,
-0.0030451843049377203,
-0.02442767471075058,
-0.0013957094633951783,
-0.014299126341938972,
0.010316113941371441,
-0.024295276030898094,
-0.02012469619512558,
-0.02352294512093067,
0.03045184351503849,
0.04106585681438446,
0.014475659467279911,
0.007623994257301092,
-0.009041770361363888,
0.05428372323513031,
0.05556358024477959,
0.0024328376166522503,
-0.006619966123253107,
-0.023743610829114914,
0.021327324211597443,
0.06942138075828552,
-0.017576009035110474,
-0.0422133170068264,
-0.01852487213909626,
0.013405431061983109,
-0.010288530960679054,
-0.042963579297065735,
-0.005764887202531099,
-0.014266027137637138,
-0.022198952734470367,
0.025773733854293823,
-0.03126830607652664,
-0.02270648255944252,
-0.0434490442276001,
-0.04616323113441467,
-0.07127496600151062,
-0.019010335206985474,
-0.03958739712834358,
-0.004473993554711342,
0.02266235090792179,
0.03590228408575058,
0.025972332805395126,
-0.008081874810159206,
0.0009971323888748884,
0.06531699746847153,
0.028509987518191338,
0.006283450871706009,
-0.015314187854528427,
0.043802108615636826,
-0.018900003284215927,
0.043780043721199036,
-0.04073485732078552,
-0.013835729099810123,
-0.011794572696089745,
-0.0008654226548969746,
0.04375797510147095,
0.00675236526876688,
-0.02005849778652191,
0.004283669870346785,
0.024802805855870247,
0.019164802506566048,
-0.0004082312516402453,
-0.018602104857563972,
0.03945499658584595,
-0.01995919831097126,
-0.02731839381158352,
-0.009792032651603222,
-0.005116682033985853,
-0.011551841162145138,
-0.05340106040239334,
0.02842172048985958,
0.008826621808111668,
0.02990018017590046,
0.03312189504504204,
-0.012953067198395729,
0.014608058147132397,
-0.00781707651913166,
-0.008826621808111668,
-0.01713467948138714,
-0.007938442751765251,
0.05525464937090874,
0.019804731011390686,
0.028090722858905792,
-0.013008233159780502,
0.004562260117381811,
-0.01436532661318779,
0.019109634682536125,
-0.03588021546602249,
0.026590196415781975,
0.015865851193666458,
-0.03512995317578316,
-0.025420669466257095,
-0.005100131966173649,
-0.01306340005248785,
0.01351576391607523,
0.008418390527367592,
-0.030849041417241096,
-0.016329249367117882,
-0.041507188230752945,
0.01713467948138714,
-0.003845097031444311,
0.06174221634864807,
-0.011386341415345669,
-0.007541244849562645,
0.0261268001049757,
0.02239755168557167,
-0.042676713317632675,
-0.03711594268679619,
-0.003492032177746296,
-0.006895797792822123,
-0.055033985525369644,
0.011220842599868774,
-0.015027322806417942,
-0.00528769800439477,
0.00284382700920105,
-0.014177760109305382,
0.017653243616223335,
0.012853767722845078,
0.017101578414440155,
0.04047005996108055,
-0.04563363268971443,
0.001803940744139254,
-0.0586087666451931,
0.00817565806210041,
0.027141861617565155,
-0.023346412926912308,
-0.06112435460090637,
-0.014597024768590927,
-0.008970053866505623,
-0.013581963256001472,
0.0024976579006761312,
0.0500028096139431,
-0.006355167366564274,
0.0541071891784668,
-0.0007923271623440087,
0.016726447269320488,
-0.029414715245366096,
-0.04309597983956337,
0.017763575538992882,
0.0006764777936041355,
0.022430650889873505,
0.01907653547823429,
-0.00008244788477895781,
-0.007226796355098486,
0.021934153512120247,
-0.0004127135034650564,
0.0039664627984166145,
-0.0036299480125308037,
-0.029436782002449036,
-0.02137145772576332,
-0.005858669988811016,
-0.00242594163864851,
-0.01871243678033352,
-0.0014619091525673866,
0.007910859771072865,
-0.024052543565630913,
0.023037482053041458,
-0.003836821997538209,
0.00668616546317935,
-0.013857795856893063,
-0.0005016693030484021,
-0.02877478487789631,
0.017653243616223335,
-0.02301541529595852,
0.021956220269203186,
-0.01930823363363743,
-0.041771985590457916,
0.027737658470869064,
0.022794749587774277,
0.005094615742564201,
0.0013715742388740182,
0.04047005996108055,
0.03932259976863861,
0.03704974427819252,
-0.012302103452384472,
0.02467040717601776,
0.035791948437690735,
-0.0045926012098789215,
0.014740457758307457,
0.03272469714283943,
-0.08160211145877838,
0.0284879207611084,
-0.04137478768825531,
-0.07560001313686371,
-0.005957969464361668,
-0.0261268001049757,
0.030032578855752945,
0.037822071462869644,
-0.04051419347524643,
0.023655345663428307,
0.002962434897199273,
0.033519092947244644,
-0.02586200088262558,
0.002376291900873184,
-0.03932259976863861,
0.06487566977739334,
-0.0350416861474514,
-0.007756393402814865,
-0.022408584132790565,
-0.010321630164980888,
-0.034887220710515976,
0.03735867515206337,
0.016384415328502655,
-0.006537216249853373,
0.03362942859530449,
-0.030562177300453186,
0.06915657967329025,
0.02473660558462143,
-0.015380388125777245,
0.006057268939912319,
-0.007359195500612259,
0.018602104857563972,
0.016362348571419716,
-0.016649214550852776,
0.04336077719926834,
-0.00433331960812211,
0.01749877631664276,
-0.025906134396791458,
0.0483698844909668,
-0.032349567860364914,
-0.01148564089089632,
0.002454904140904546,
-0.008021192625164986,
0.023059548810124397,
-0.014254993759095669,
-0.044375840574502945,
0.031091773882508278,
0.05693170800805092,
0.04629562795162201,
-0.017576009035110474,
0.02194518782198429,
-0.013901928439736366,
-0.0227506160736084,
-0.001576379407197237,
0.0026217824779450893,
0.05313625931739807,
-0.009874782525002956,
-0.03157723695039749,
0.07943959534168243,
-0.0016963663510978222,
0.02143765613436699,
0.03482102230191231,
0.009240369312465191,
0.03704974427819252,
-0.005406305659562349,
0.0017984240548685193,
-0.03704974427819252,
-0.0043250443413853645,
0.009896849282085896,
0.008561822585761547,
-0.02934851683676243,
-0.04832575097680092,
0.005858669988811016,
0.012445536442101002,
-0.02531033754348755,
0.011960071511566639,
0.02084185928106308,
-0.018061473965644836,
0.055916644632816315,
-0.030032578855752945,
0.06646446138620377,
0.04576603323221207,
-0.0010095448233187199,
0.006669615861028433,
-0.037800006568431854,
0.025751667097210884,
-0.043824173510074615,
0.03742487356066704,
-0.02414080873131752,
0.03855026885867119,
0.0010991902090609074,
0.007530211471021175,
-0.019297201186418533,
-0.009775483049452305,
-0.0196723323315382,
0.027737658470869064,
0.02409667707979679,
0.00003534096322255209,
-0.007822592742741108,
-0.00890385452657938,
0.02870858646929264,
-0.016384415328502655,
0.007861210033297539,
0.048678815364837646,
0.002250788500532508,
-0.007425395306199789,
-0.0016425790963694453,
-0.014740457758307457,
0.0008371498552151024,
0.059623826295137405,
0.006029685493558645,
-0.015810685232281685,
-0.06439020484685898,
-0.04389037564396858,
0.042367782443761826,
-0.0012598623288795352,
-0.014188793487846851,
-0.013284064829349518,
0.02787005715072155,
-0.01835937239229679,
0.03444588929414749,
-0.03938879817724228,
0.003089317586272955,
-0.030562177300453186,
-0.018557971343398094,
0.011573906987905502,
-0.027362525463104248,
0.03140070661902428,
0.027980389073491096,
0.0011860772501677275,
0.018348339945077896,
-0.042345717549324036,
-0.015590019524097443,
-0.04166165366768837,
-0.02926024980843067,
-0.00016713689547032118,
0.020731527358293533,
-0.00025117944460362196,
0.008335640653967857,
0.022309284657239914,
-0.04461856931447983,
0.0013646783772855997,
0.01924203522503376,
0.01162907388061285,
-0.047266557812690735,
0.016748514026403427,
-0.012633102014660835,
-0.007811559829860926,
0.03358529508113861,
0.03296742960810661,
-0.020687393844127655,
0.03309983015060425,
-0.04013906046748161,
0.0031693086493760347,
0.01579965278506279,
0.008942470885813236,
-0.011926972307264805,
-0.021503856405615807,
0.03883713483810425,
-0.0001092983948183246,
0.0002803141833283007,
-0.01207040436565876,
-0.0019170318264514208,
-0.013019266538321972,
-0.008572855964303017,
-0.037800006568431854,
0.0028879602905362844,
0.02127215825021267,
0.023037482053041458,
-0.04071279242634773,
0.014133627526462078,
-0.05141507089138031,
0.03616708144545555,
0.017300177365541458,
0.0007330233347602189,
0.018315238878130913,
-0.008120492100715637,
-0.02559720166027546,
-0.02820105478167534,
-0.022927148267626762,
-0.007419878616929054,
0.010873294435441494,
-0.0017832533922046423,
0.013559897430241108,
0.005141506902873516,
0.01883380301296711,
-0.003263091668486595,
0.04428757354617119,
-0.0009840303100645542,
0.01979369856417179,
0.06672925502061844,
-0.0006716506904922426,
0.03713800758123398,
-0.032614365220069885,
-0.009245885536074638,
0.058741163462400436,
0.002352846320718527,
-0.056490376591682434,
-0.01797320693731308,
-0.038108937442302704,
-0.0003194478340446949,
-0.0024135292042046785,
-0.012434503063559532,
-0.003144483780488372,
-0.018866904079914093,
0.0192641019821167,
0.011093960143625736,
0.014199826866388321,
-0.023390546441078186,
-0.039830129593610764,
-0.0155238201841712,
-0.02586200088262558,
-0.008126008324325085,
0.015170755796134472,
-0.007254379335790873,
-0.005792470183223486,
0.026546062901616096,
-0.013791595585644245,
0.0009840303100645542,
-0.029370581731200218,
0.0284879207611084,
-0.012544835917651653,
-0.03501962125301361,
0.0043526277877390385,
-0.01349369715899229,
0.010746411047875881,
-0.004763617180287838,
-0.010669178329408169,
0.02194518782198429,
-0.010222330689430237,
-0.03506375476717949,
0.03466655686497688,
-0.02352294512093067,
0.01350473053753376,
-0.03733660653233528,
0.027980389073491096,
0.007215762976557016,
0.02301541529595852,
-0.008109458722174168,
-0.02186795510351658,
-0.0270535945892334,
-0.02811278961598873,
-0.01797320693731308,
-0.03994046151638031,
0.0026424697134643793,
0.022838883101940155,
-0.024869006127119064,
-0.030385643243789673,
0.03153310343623161,
0.003425832372158766,
-0.02842172048985958,
-0.037446942180395126,
0.03994046151638031,
-0.016858845949172974,
0.0020508102606981993,
-0.006261384580284357,
-0.006735815200954676,
0.05401892215013504,
0.01840350590646267,
-0.017145711928606033,
0.014685290865600109,
-0.01293100044131279,
0.013835729099810123,
-0.023743610829114914,
0.016958145424723625,
-0.025155870243906975,
0.03561541810631752,
0.0029845014214515686,
0.024493874981999397,
-0.03581401705741882,
0.01104431040585041,
0.00688476487994194,
-0.011562873609364033,
0.039477065205574036,
-0.02500140480697155,
0.0243835411965847,
0.006995097268372774,
-0.0620952807366848,
0.009400351904332638,
-0.009582401253283024,
-0.011320142075419426,
0.008506656624376774,
-0.0182380061596632,
0.011331175453960896,
0.0011040172539651394,
0.0069675142876803875,
-0.04806095361709595,
-0.007309545762836933,
0.028532054275274277,
-0.006862698122859001,
-0.02928231656551361,
0.027759723365306854,
0.014166727662086487,
0.042367782443761826,
0.016097551211714745,
-0.04080105572938919,
0.011805606074631214,
0.04192645102739334,
0.002896235091611743,
-0.00947758462280035,
-0.013979161158204079,
0.0049070497043430805,
-0.027075661346316338,
-0.01921996846795082,
0.005431130528450012,
-0.0329894982278347,
0.0013329577632248402,
-0.006283450871706009,
-0.04770788922905922,
-0.03682907670736313,
-0.0037126976530998945,
0.026016466319561005,
0.022816816344857216,
-0.0013433013809844851,
-0.018745537847280502,
-0.0019459942122921348,
0.02844378724694252,
-0.00462570134550333,
-0.030297378078103065,
-0.01563415303826332,
-0.032901231199502945,
-0.007166113238781691,
-0.0018825528677552938,
-0.018171805888414383,
0.004871191456913948,
-0.014310159720480442,
-0.010862261056900024,
0.008843171410262585,
-0.011198775842785835,
-0.02963538095355034,
0.0037071809638291597,
-0.008379773236811161,
-0.007673643995076418,
0.002261821646243334,
-0.006956480909138918,
0.015954118221998215,
-0.019484765827655792,
0.013604030013084412,
-0.002570753451436758,
0.007668127305805683,
-0.012280036695301533,
0.05741717293858528,
0.057902637869119644,
-0.031709637492895126,
0.01565621979534626,
-0.01054229587316513,
-0.0011191880330443382,
-0.030341511592268944,
-0.0026948777958750725,
0.014652191661298275,
-0.0020163313020020723,
0.028554121032357216,
-0.015281088650226593,
0.08985500782728195,
0.010476096533238888,
-0.003613398177549243,
-0.027119794860482216,
0.009582401253283024,
0.019970230758190155,
0.013890895061194897,
-0.00971479993313551,
-0.028576185926795006,
-0.01147460751235485,
0.004176095128059387,
0.00603520218282938,
-0.007348162122070789,
-0.04629562795162201,
-0.01785184256732464,
0.00401611253619194,
0.02586200088262558,
0.01957303285598755,
0.003927846439182758,
0.00457053491845727,
0.009753416292369366,
-0.021647289395332336,
-0.022496851161122322,
0.0024038751143962145,
0.0358581505715847,
0.04155132174491882,
-0.005775920581072569,
-0.02194518782198429,
-0.013217865489423275,
-0.020874960348010063,
0.010773994959890842,
0.008285990916192532,
0.042389847338199615,
-0.039499130100011826,
0.03499755263328552,
-0.02502347156405449,
0.0377117395401001,
-0.008953504264354706,
0.03391629084944725,
0.026590196415781975,
0.0025873032864183187,
0.013923995196819305,
-0.010465063154697418,
0.0005692481063306332,
0.019131701439619064,
-0.011728373356163502,
0.019628198817372322,
0.03671874478459358,
-0.005458713509142399,
0.025067605078220367,
0.00246455823071301,
0.011573906987905502,
-0.02667846344411373,
0.022044487297534943,
0.0315551720559597,
0.02610473334789276,
-0.0336073599755764,
0.07092190533876419,
0.007337129209190607,
0.002522483002394438,
0.01983783207833767,
-0.033474963158369064,
-0.030407710000872612,
-0.012677234597504139,
-0.02731839381158352,
0.0415954515337944,
-0.029679514467716217,
0.0073260958306491375,
-0.04223538190126419,
-0.006614449433982372,
0.0064765335991978645,
-0.05432785302400589,
-0.005436647217720747,
0.00874938815832138,
0.002987259766086936,
0.03129037097096443,
0.016384415328502655,
-0.0010440237820148468,
0.0026838446501642466,
-0.0321730338037014,
-0.0038975048810243607,
0.0063386172987520695,
-0.0019901273772120476,
0.0009612742578610778,
0.006917864549905062,
-0.021779688075184822,
0.02906165085732937,
0.005957969464361668,
-0.010851227678358555,
-0.034092824906110764,
-0.021161824464797974,
0.002264579990878701,
-0.009764449670910835,
0.013361298479139805,
0.0034478988964110613,
0.020521894097328186,
0.028576185926795006,
0.02057706192135811,
0.0033872160129249096,
-0.01222487073391676,
0.0012771018082275987,
-0.0005013245390728116,
0.0074143619276583195,
-0.024560073390603065,
-0.008396323770284653,
0.019109634682536125,
-0.0379103384912014,
-0.014972156845033169,
-0.026568129658699036,
0.017730476334691048,
-0.003894746769219637,
0.01365919690579176,
-0.02670053020119667,
0.0014108802424743772,
0.010244397446513176,
-0.0015736210625618696,
0.012467602267861366,
0.032901231199502945,
-0.03515201807022095,
-0.02072049304842949,
-0.014894923195242882,
0.026899129152297974,
-0.01862417161464691,
0.014519792050123215,
-0.014740457758307457,
0.03994046151638031,
0.044088974595069885,
-0.0602416917681694,
-0.018602104857563972,
0.0175208430737257,
-0.011441508308053017,
-0.007712260354310274,
0.00437469407916069,
-0.02387601137161255,
0.00555801298469305,
0.040999654680490494,
-0.0063386172987520695,
-0.0017253286205232143,
-0.013846762478351593,
0.016880912706255913,
-0.016218917444348335,
-0.0033210162073373795,
-0.02932645007967949,
0.005582837853580713,
-0.033519092947244644,
-0.011971104890108109,
0.029392648488283157,
0.0032327501103281975,
-0.007083363831043243,
-0.03362942859530449,
0.06244834512472153,
-0.008694222196936607,
0.016958145424723625,
-0.019848864525556564,
-0.0023252631071954966,
-0.04576603323221207,
-0.032923296093940735,
0.002755560912191868,
0.018105607479810715,
-0.0336073599755764,
0.02901751734316349,
0.0051580569706857204,
-0.03537268564105034,
0.03704974427819252,
-0.007574344519525766,
-0.03453415632247925,
-0.011309108696877956,
-0.014122594147920609,
0.011551841162145138,
0.026060599833726883,
0.023699479177594185,
-0.006570316385477781,
-0.006244834512472153,
-0.023942209780216217,
-0.002807968994602561,
0.01735534518957138,
-0.008081874810159206,
0.016141684725880623,
-0.03680701181292534,
-0.05807916820049286,
-0.022121720016002655,
-0.011871805414557457,
-0.026215065270662308,
-0.0013750221114605665,
0.04479510337114334,
0.01656094752252102,
0.004752583801746368,
-0.03733660653233528,
0.04148511961102486,
0.02524413727223873,
-0.028554121032357216,
-0.014453592710196972,
-0.01478459034115076,
0.0014591508079320192,
0.024935204535722733,
-0.05609317868947983,
0.017145711928606033,
-0.010404380038380623,
-0.005599387921392918,
-0.03581401705741882,
0.038351669907569885,
-0.002144593046978116,
0.012456569820642471,
-0.036895278841257095,
-0.003988529555499554,
-0.010878810659050941,
0.02084185928106308,
0.005764887202531099,
0.013217865489423275,
-0.00877145491540432,
0.019727498292922974,
-0.014663225039839745,
-0.0020921851973980665,
-0.0070116473361849785,
-0.0010454029543325305,
-0.013670230284333229,
-0.01553485356271267,
0.008854204788804054,
-0.012555869296193123,
-0.007464011665433645,
0.0016163750551640987,
-0.0024976579006761312,
-0.008252890780568123,
0.011331175453960896,
0.010167164728045464,
0.019418567419052124,
-0.01723397895693779,
0.06567006558179855,
-0.03998459503054619,
0.007127496879547834,
-0.015744484961032867,
-0.02762732468545437,
-0.019065503031015396,
0.04558949917554855,
0.01508248969912529,
0.01150770764797926,
-0.023456746712327003,
0.03974186256527901,
-0.01859107054769993,
0.01641751639544964,
-0.028818918392062187,
0.002270096680149436,
0.012269003316760063,
0.026788795366883278,
-0.007977059110999107,
0.006603416055440903,
-0.02791419066488743,
0.05234186351299286,
-0.007116463501006365,
0.0243835411965847,
-0.03528441861271858,
0.00473327562212944,
-0.015490720048546791,
0.017576009035110474,
0.0073702288791537285,
-0.023478813469409943,
-0.012456569820642471,
0.002885201945900917,
0.007408845238387585,
-0.01220280397683382,
-0.011827672831714153,
-0.007182663306593895,
0.03212890028953552,
-0.005144265480339527,
0.0313565731048584,
0.030319444835186005,
0.013328198343515396,
0.00035340964677743614,
-0.01627408340573311,
-0.016858845949172974,
-0.023699479177594185,
0.03323223069310188,
0.008236341178417206,
-0.03700561076402664,
-0.017862875014543533,
0.008848687633872032,
0.008506656624376774,
-0.030937308445572853,
0.008815588429570198,
0.05234186351299286,
0.07056883722543716,
0.00528769800439477,
0.02077566087245941,
0.027097728103399277,
-0.017984241247177124,
-0.029701581224799156,
0.021525923162698746,
-0.025376535952091217,
0.04232364892959595,
-0.04490543529391289,
-0.01893310248851776,
0.002459041541442275,
-0.013306131586432457,
-0.011110509745776653,
-0.00842390675097704,
0.04947321116924286,
0.000049175658205058426,
0.011182226240634918,
-0.07414361834526062,
0.020808760076761246,
-0.02619299851357937,
-0.005315280985087156,
0.03506375476717949,
0.009494134224951267,
-0.010481612756848335,
0.04250018298625946,
0.019606132060289383,
-0.01040989626199007,
0.0053125228732824326,
0.02703152783215046,
0.03424729034304619,
0.015016289427876472,
-0.03526235371828079,
-0.007806043140590191,
-0.019926097244024277,
0.017311211675405502,
-0.02703152783215046,
-0.024648340418934822,
-0.02108459174633026,
0.012588968500494957,
0.01436532661318779,
0.059888627380132675,
-0.01993713155388832,
-0.053930655121803284,
0.026656396687030792,
-0.03610088303685188,
-0.0299222469329834,
-0.04256638139486313,
0.010503679513931274,
0.040977589786052704,
-0.02811278961598873,
-0.03226130083203316,
0.023699479177594185,
0.012765500694513321,
-0.044375840574502945,
-0.01909860223531723,
0.04230158403515816,
-0.021878987550735474,
0.033805958926677704,
-0.01809457316994667,
0.02387601137161255,
0.03186410292983055,
0.01641751639544964,
0.0026452280580997467,
-0.002158384770154953,
-0.030804907903075218,
-0.010106481611728668,
-0.026943260803818703,
-0.027980389073491096,
0.008451489731669426,
0.0006644101231358945,
-0.010371279902756214,
0.011761472560465336,
0.04823748394846916,
0.013217865489423275,
-0.0020397771149873734,
0.016240984201431274,
-0.017631176859140396,
0.007872242480516434,
-0.0002248030068585649,
0.04274291545152664,
-0.002973468042910099,
0.004181611817330122,
-0.03702767565846443,
-0.012500702403485775,
0.030849041417241096,
-0.014045361429452896,
0.07489388436079025,
0.019915064796805382,
0.004843608476221561,
-0.06500806659460068,
-0.005284939426928759,
-0.00545043870806694,
0.03907986730337143,
-0.026634329929947853,
-0.02361121214926243,
0.0009398972615599632,
-0.00373476417735219,
0.0074143619276583195,
0.04472890496253967,
0.03356322646141052,
0.02504553832113743,
-0.001537762931548059,
0.015578987076878548,
-0.018414538353681564,
0.01234623696655035,
0.008330123499035835,
0.030319444835186005,
-0.01912066899240017,
-0.01422189362347126,
0.0008330123964697123,
0.02416287548840046,
-0.009433452039957047,
-0.005279422737658024,
-0.016737481579184532,
0.010956043377518654,
0.028399653732776642,
0.02784799039363861,
0.00516909034922719,
-0.015281088650226593,
0.01100569311529398,
-0.0011102234711870551,
-0.019164802506566048,
0.02475867234170437,
-0.016174783930182457,
0.001988748088479042,
-0.01033818069845438,
0.007883275859057903,
0.0016467164969071746,
-0.007348162122070789,
-0.01983783207833767,
0.005218740087002516,
0.038881268352270126,
-0.011529774405062199,
-0.0058752200566232204,
-0.0005785574321635067,
-0.0329894982278347,
-0.03131243959069252,
0.008854204788804054,
0.0028217604849487543,
-0.0006402748404070735,
0.016858845949172974,
-0.024891072884202003,
0.011938005685806274,
-0.029105784371495247,
-0.01754290983080864,
-0.014177760109305382,
0.012136604636907578,
0.032283369451761246,
-0.008561822585761547,
-0.0344238243997097,
0.02229825221002102,
0.00016903324285522103,
-0.02559720166027546,
-0.02237548492848873,
0.03510788828134537,
-0.027428725734353065,
-0.025486869737505913,
0.013979161158204079,
0.03482102230191231,
-0.02672259695827961,
0.012997199781239033,
0.010321630164980888,
-0.0006475154077634215,
0.011805606074631214,
0.03389422595500946,
0.022386519238352776,
-0.033739760518074036,
0.014674258418381214,
0.004782925359904766,
-0.020566027611494064,
-0.02055499516427517,
-0.00775087671354413,
0.013957095332443714,
-0.01234623696655035,
-0.019473733380436897,
-0.02139352262020111,
0.012257970869541168,
-0.004418827127665281,
0.02414080873131752,
-0.005770403891801834,
-0.00037857930874451995,
-0.00717714661732316,
0.02729632705450058,
-0.018160773441195488,
0.0029514015186578035,
-0.0017446369165554643,
-0.0014315677108243108,
0.005924869794398546,
0.02186795510351658,
0.02502347156405449,
0.006504116579890251,
-0.005215981509536505,
-0.012975133024156094,
-0.006437916774302721,
-0.02467040717601776,
0.0015777585795149207,
0.05048827454447746,
-0.03367356210947037,
-0.04964974522590637,
0.06002102419734001,
0.007673643995076418,
-0.015325221233069897,
-0.016263049095869064,
-0.0215148888528347,
0.002454904140904546,
0.011165675707161427,
-0.009378285147249699,
0.018988268449902534,
0.03625534847378731,
-0.005295972805470228,
-0.006173118483275175,
0.005386997479945421,
-0.021338356658816338,
0.007287479471415281,
-0.008947987109422684,
-0.001857727998867631,
0.0038257886189967394,
0.014177760109305382,
-0.027450792491436005,
0.0014398426283150911,
0.016141684725880623,
0.009709283709526062,
0.060727156698703766,
0.02256305143237114,
0.0057152374647557735,
0.059005964547395706,
0.0043250443413853645,
-0.005166331771761179,
-0.01787390746176243,
-0.00682959845289588,
-0.034070760011672974,
-0.0076405443251132965,
-0.018127674236893654,
-0.019352367147803307,
0.0025431702379137278,
0.005124956835061312,
-0.009814099408686161,
0.0016329250065609813,
0.007226796355098486,
-0.014729424379765987,
-0.022309284657239914,
-0.02043362893164158,
-0.0010922943474724889,
0.024493874981999397,
-0.005836603231728077,
0.0023749128449708223,
-0.03618914633989334,
-0.00023928418522700667,
0.02760525792837143,
-0.003947154618799686,
-0.006768915336579084,
0.03786620497703552,
0.016196850687265396,
0.020753594115376472,
0.005406305659562349,
-0.0007157838554121554,
0.0075467610731720924,
-0.007635027635842562,
-0.0700833722949028,
0.03945499658584595,
-0.017465677112340927,
-0.0004199540999252349,
0.009781000204384327,
-0.01914273574948311,
-0.03581401705741882,
-0.023699479177594185,
0.0010729861678555608,
-0.016671281307935715,
-0.0006530320388264954,
0.0030451843049377203,
-0.006917864549905062,
0.01940753310918808,
0.00876042153686285,
-0.00026635019457899034,
-0.050708938390016556,
0.01651681587100029,
0.020179864019155502,
0.0005895907524973154,
-0.0030727675184607506,
-0.04472890496253967,
-0.008826621808111668,
0.008754905313253403,
0.0015874126693233848,
0.002876926911994815,
-0.010382313281297684,
0.014199826866388321,
-0.006719265598803759,
0.00676339864730835,
0.04625149443745613,
-0.008881787769496441,
0.019153768196702003,
-0.03713800758123398,
-0.016196850687265396,
-0.00803222507238388,
-0.030672509223222733,
0.010867777280509472,
0.024361474439501762,
0.030275311321020126,
-0.01924203522503376,
-0.022927148267626762,
-0.02354501187801361,
0.02051086165010929,
-0.0261268001049757,
-0.009317602030932903,
0.015601052902638912,
0.014299126341938972,
-0.016869880259037018,
-0.018922070041298866,
0.009030736982822418,
0.010591945610940456,
0.02010262943804264,
0.009008670225739479,
0.010459545999765396,
-0.017509810626506805,
-0.03762347251176834,
-0.006482050288468599,
0.007756393402814865,
0.03329842910170555,
0.014034328050911427,
-0.019109634682536125,
0.030385643243789673,
-0.03727040812373161,
0.04656042903661728,
0.018877936527132988,
0.01205937098711729,
-0.034578289836645126,
-0.03868266940116882,
0.0073260958306491375,
-0.004631218034774065,
0.01205937098711729,
0.0005582148442044854,
0.03874886780977249,
-0.0036464978475123644,
-0.005182881839573383,
0.031488969922065735,
-0.021349390968680382,
0.021901054307818413,
-0.010089932009577751,
0.005764887202531099,
0.005599387921392918,
-0.02467040717601776,
-0.010851227678358555,
0.0133723309263587,
0.003784413915127516,
-0.00564627954736352,
0.012622068636119366,
-0.01899930275976658,
0.012975133024156094,
-0.005351139232516289,
-0.032614365220069885,
0.0025638577062636614,
-0.023390546441078186,
-0.05481331795454025,
-0.05741717293858528,
0.012611035257577896,
0.009626533836126328,
-0.017454644665122032,
0.0012157291639596224,
0.0005537325632758439,
0.006575833074748516,
0.028576185926795006,
-0.023456746712327003,
-0.0075026280246675014,
0.04532470181584358,
0.006630999501794577,
0.0019625441636890173,
-0.013670230284333229,
0.007866726256906986,
0.03252609819173813,
-0.014552892185747623,
-0.0014315677108243108,
-0.02237548492848873,
0.02387601137161255,
0.01921996846795082,
0.0011198775609955192,
0.01885586977005005,
0.0541071891784668,
0.006708232220262289,
0.017454644665122032,
0.00534286443144083,
-0.01553485356271267,
0.022165853530168533,
-0.026921195909380913,
-0.01508248969912529,
-0.00866663921624422,
-0.004507093690335751,
-0.038042739033699036,
-0.01610858365893364,
0.01577758602797985,
-0.00036754601751454175,
0.0020783934742212296,
0.021492822095751762,
0.04373591020703316,
-0.03164343908429146,
-0.01787390746176243,
0.013570930808782578,
0.05459265410900116,
-0.004912566393613815,
0.011452541686594486,
-0.03760140761733055,
-0.02383187785744667,
-0.006018652580678463,
0.012754468247294426,
0.0002056671801256016,
-0.03223923593759537,
0.012147638015449047,
-0.008479072712361813,
0.008137041702866554,
0.026612263172864914,
-0.0022149302531033754,
-0.003287916537374258,
-0.02022399567067623,
-0.004791200626641512,
-0.015711385756731033,
-0.011982138268649578,
-0.0062062181532382965,
-0.005307006184011698,
-0.008992120623588562,
-0.01604238525032997,
0.0024369750171899796,
-0.023191947489976883,
0.02112872526049614,
0.0010219572577625513,
-0.015612086281180382,
0.020919091999530792,
-0.0037623473908752203,
-0.02442767471075058,
0.021934153512120247,
-0.01938546635210514,
0.007623994257301092,
-0.01610858365893364,
-0.0336073599755764,
-0.012533802539110184,
0.00012929621152579784,
0.0023418129421770573,
0.006537216249853373,
-0.05379825830459595,
0.017962174490094185,
0.019617166370153427,
0.014850790612399578,
0.007441944908350706,
0.0028355522081255913,
-0.005022899247705936,
-0.015016289427876472,
-0.022265153005719185,
0.01709054596722126,
0.003050700994208455,
0.02141558937728405,
-0.023037482053041458,
-0.017741508781909943,
-0.027715591713786125,
0.003172066994011402,
-0.007822592742741108,
-0.02475867234170437,
-0.022838883101940155,
0.01909860223531723,
-0.0033485994208604097,
0.024030476808547974,
0.013206832110881805,
-0.00617863517254591,
-0.003279641503468156,
0.01993713155388832,
-0.035240285098552704,
0.020257096737623215,
-0.024229075759649277,
0.016914013773202896,
0.03276883065700531,
0.04397864267230034,
-0.015545886941254139,
-0.0012619310291483998,
-0.009775483049452305,
0.0026452280580997467,
-0.026854995638132095,
0.014674258418381214,
0.0284879207611084,
-0.01656094752252102,
-0.03449002280831337,
0.028090722858905792,
0.02791419066488743,
-0.03903573378920555,
-0.007491595111787319,
-0.02820105478167534,
-0.012257970869541168,
0.009549301117658615,
-0.04336077719926834,
0.013780562207102776,
0.048987749963998795,
0.005602146033197641,
-0.009411385282874107,
0.03210683539509773,
-0.04761962220072746,
0.02875271998345852,
-0.022187920287251472,
-0.012633102014660835,
0.01551278680562973,
-0.016009284183382988,
-0.02758319117128849,
0.0038975048810243607,
0.029745714738965034,
0.006548249628394842,
0.01876760460436344,
0.016914013773202896,
-0.014023294672369957,
0.015623119659721851,
-0.028355520218610764,
-0.005447680596262217,
0.0007626752485521138,
-0.008848687633872032,
-0.0059800357557833195,
0.020952193066477776,
0.013747463002800941,
0.006239317823201418,
0.015601052902638912,
0.013813662342727184,
-0.02440560795366764,
-0.0016425790963694453,
-0.007778460159897804,
-0.006691682152450085,
-0.00781707651913166,
-0.01221383735537529,
0.12569108605384827,
-0.030385643243789673,
-0.0024976579006761312,
0.001828765613026917,
0.01589895226061344,
-0.02619299851357937,
0.036652546375989914,
-0.0027293567545711994,
0.015744484961032867,
-0.014541858807206154,
0.011673206463456154,
0.0198819637298584,
0.050135210156440735,
0.017145711928606033,
0.02727426029741764,
-0.005538704805076122,
0.00305621768347919,
0.056446243077516556,
0.014001227915287018,
-0.01076847780495882,
0.013008233159780502,
-0.0019184109987691045,
-0.010023731738328934,
0.023346412926912308,
-0.04203678295016289,
0.012820667587220669,
0.010095448233187199,
-0.00049684225814417,
-0.01897723600268364,
-0.007927409373223782,
0.007017164025455713,
0.00830805767327547,
0.01934133470058441,
-0.02297128178179264,
0.0012626205570995808,
-0.03325429558753967,
-0.009323119185864925,
-0.026832928881049156,
0.0029017517808824778,
0.00753572816029191,
0.011915938928723335,
0.004018871113657951,
0.004705692641437054,
0.004937391262501478,
0.019352367147803307,
0.02583993412554264,
-0.02698739431798458,
0.01493905670940876,
0.0008364602690562606,
-0.009736866690218449,
0.0007392295519821346,
-0.023787744343280792,
-0.00492911646142602,
-0.0364760123193264,
-0.041749920696020126,
-0.011827672831714153,
0.008225307799875736,
0.0017156745307147503,
0.011573906987905502,
-0.02385394461452961,
-0.002037018770352006,
0.038086872547864914,
0.016406482085585594,
-0.006702715530991554,
0.019253067672252655
] | 2024-07-18 | 1 | 39019408 | [
"CAR T cells",
"CAR T cell therapy",
"T cell therapy",
"endothelial cell anergy",
"solid tumors",
"tumor progression",
"tumors",
"such adhesion molecules",
"reduced leukocyte adhesion molecule expression",
"anti-tumor immunity",
"endogenous immunity",
"CAR",
"cellular therapeutics",
"cellular immunotherapies",
"angiogenic growth factors",
"both endogenous immune cells",
"the endothelial cells",
"angiogenesis inhibitors",
"similar success",
"significant results",
"inflammatory cytokines",
"leukocyte extravasation",
"Chimeric antigen receptor",
"The tumor vasculature",
"challenges",
"the tumor microenvironment",
"the tumor parenchyma",
"hematologic malignancies",
"infiltration",
"leukocytes"
] | [
"Angiogenesis",
"Anti-angiogenic therapy",
"Immunotherapy",
"Pro-angiogenic factors",
"Tumor endothelial cells",
"Tumor vasculature"
] | 0 | 10.1016/j.bbcan.2024.189155 | [
"Wachholz",
"Akbari",
"Huijbers",
"Jalan",
"van Beijnum",
"Griffioen"
] | [
"Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, the Netherlands.",
"Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, the Netherlands.",
"Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, the Netherlands.",
"Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, the Netherlands.",
"Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, the Netherlands.",
"Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, the Netherlands. Electronic address: [email protected]."
] | [
"39019408"
] | [] | 9.867215 | 4.918731 |
39019005 | 716 | PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies. | Tumor-infiltrating regulatory T cells (TI-Tregs) elicit immunosuppressive effects in the tumor microenvironment (TME) leading to accelerated tumor growth and resistance to immunotherapies against solid tumors. Here, we demonstrate that poly-(ADP-ribose)-polymerase-11 (PARP11) is an essential regulator of immunosuppressive activities of TI-Tregs. Expression of PARP11 correlates with TI-Treg cell numbers and poor responses to immune checkpoint blockade (ICB) in human patients with cancer. Tumor-derived factors including adenosine and prostaglandin E2 induce PARP11 in TI-Tregs. Knockout of PARP11 in the cells of the TME or treatment of tumor-bearing mice with selective PARP11 inhibitor ITK7 inactivates TI-Tregs and reinvigorates anti-tumor immune responses. Accordingly, ITK7 decelerates tumor growth and significantly increases the efficacy of anti-tumor immunotherapies including ICB and adoptive transfer of chimeric antigen receptor (CAR) T cells. These results characterize PARP11 as a key driver of TI-Treg activities and a major regulator of immunosuppressive TME and argue for targeting PARP11 to augment anti-cancer immunotherapies. | [
-0.014907902106642723,
0.007362350821495056,
0.01825130172073841,
0.05143340677022934,
-0.03384620323777199,
-0.01874365285038948,
-0.0034750753547996283,
0.018216952681541443,
-0.015858251601457596,
-0.04772360622882843,
0.013087351806461811,
0.019293252378702164,
0.03753310441970825,
-0.033663004636764526,
0.027571603655815125,
-0.04231920465826988,
0.084455206990242,
0.027983803302049637,
0.004537063185125589,
0.1154160127043724,
-0.01151870097965002,
-0.00919435080140829,
-0.05299060791730881,
0.005965450778603554,
-0.00020323751959949732,
0.02500680275261402,
0.02500680275261402,
0.020106201991438866,
0.030067702755331993,
-0.008879476226866245,
0.02312900312244892,
-0.023816002532839775,
-0.025556402280926704,
-0.02034665271639824,
-0.0013174657942727208,
-0.009806926362216473,
0.02727390266954899,
-0.025350302457809448,
-0.020048951730132103,
-0.002036669058725238,
0.0258083026856184,
-0.0258083026856184,
-0.04124290496110916,
0.050746407359838486,
-0.05363180488348007,
-0.019132953137159348,
0.002015200210735202,
-0.032128702849149704,
0.002895419020205736,
-0.01986575312912464,
-0.021583251655101776,
0.02486940287053585,
-0.0216977521777153,
0.0694786086678505,
-0.06141780689358711,
0.0361362025141716,
-0.0021254064049571753,
0.012125551700592041,
-0.0024946690537035465,
-0.003804262960329652,
0.013854501768946648,
-0.010929026640951633,
0.03824300318956375,
-0.024457203224301338,
-0.04538780450820923,
0.00578225078061223,
-0.0675550103187561,
-0.013671301305294037,
0.001132118864916265,
-0.017106302082538605,
0.015629252418875694,
0.020678702741861343,
-0.03748730570077896,
-0.003927350509911776,
0.03666290268301964,
0.014862101525068283,
0.00907985121011734,
0.030937904492020607,
0.03668580576777458,
-0.029060102999210358,
0.07726460695266724,
-0.005218338221311569,
0.054181408137083054,
-0.006835650652647018,
-0.014953701756894588,
-0.007287926040589809,
-0.02979290299117565,
-0.06082240864634514,
-0.0713106095790863,
-0.010402326472103596,
0.019648201763629913,
-0.003804262960329652,
-0.028167003765702248,
0.06260860711336136,
0.011140851303935051,
-0.03680030256509781,
-0.005166813265532255,
-0.03805980458855629,
0.03480800241231918,
0.06389100849628448,
0.04664730653166771,
-0.00988707598298788,
-0.028968503698706627,
-0.025190003216266632,
0.013144601136446,
0.033296603709459305,
-0.04781520739197731,
-0.03764760494232178,
0.047036606818437576,
0.024663303047418594,
0.059723205864429474,
0.011306876316666603,
-0.03950250521302223,
0.033205002546310425,
-0.03377750515937805,
-0.06489861011505127,
-0.028327303007245064,
0.029060102999210358,
0.023495402187108994,
0.0041992878541350365,
-0.009234425611793995,
-0.0023386627435684204,
-0.015446051955223083,
-0.01335070189088583,
-0.02942650392651558,
-0.03858650475740433,
0.06645581126213074,
-0.03176230192184448,
0.013488101772964,
-0.03947960585355759,
0.017598651349544525,
0.00687572592869401,
0.04302910342812538,
0.04708240553736687,
0.011358401738107204,
-0.019018452614545822,
-0.02360990270972252,
0.035403404384851456,
0.016568152233958244,
0.00008015000639716163,
-0.016625402495265007,
0.01278965175151825,
-0.017140651121735573,
-0.018285652622580528,
-0.034281302243471146,
-0.0821194127202034,
0.007161975838243961,
-0.00492922542616725,
0.016705552116036415,
0.016167402267456055,
-0.017518501728773117,
0.005627675447613001,
0.031029503792524338,
0.020094752311706543,
-0.003778500482439995,
-0.037807904183864594,
-0.01748415268957615,
0.0455252043902874,
-0.007047475781291723,
0.006394825875759125,
-0.07786001265048981,
0.025602202862501144,
-0.04543360695242882,
0.014507152140140533,
0.009658075869083405,
0.026266302913427353,
0.03018220327794552,
0.04699080437421799,
-0.04126580432057381,
-0.006646725814789534,
-0.01712920144200325,
-0.06769240647554398,
-0.06393680721521378,
0.015572002157568932,
-0.031510405242443085,
-0.009514951147139072,
-0.02114815264940262,
0.043990906327962875,
-0.008238275535404682,
-0.003380612935870886,
-0.03929640352725983,
0.01949935220181942,
-0.007047475781291723,
0.023953402414917946,
-0.009703876450657845,
0.0064692506566643715,
-0.03251800313591957,
0.014163651503622532,
-0.05720420554280281,
0.014793401584029198,
0.06050180643796921,
-0.0029941753018647432,
0.05550960823893547,
0.007860425859689713,
-0.025510603561997414,
-0.021903852000832558,
0.030434103682637215,
0.03041120432317257,
-0.012732401490211487,
0.02003750205039978,
0.013156051747500896,
-0.010929026640951633,
-0.057891204953193665,
0.0017146377358585596,
-0.04440310597419739,
-0.019797053188085556,
0.0024789252784103155,
0.02213285304605961,
-0.027525803074240685,
0.026106003671884537,
0.03631940484046936,
-0.0031058129388839006,
0.019293252378702164,
0.003374887863174081,
0.04721980541944504,
0.01690020225942135,
0.0022055564913898706,
0.016625402495265007,
0.014003351330757141,
0.03670870512723923,
-0.046899206936359406,
-0.017965052276849747,
-0.039433803409338,
0.04749460518360138,
-0.020472602918744087,
0.016155952587723732,
0.01012752577662468,
-0.005387225653976202,
-0.036342304199934006,
0.007574175950139761,
-0.02825860306620598,
0.02688460238277912,
0.014163651503622532,
-0.000723854755051434,
-0.022911451756954193,
-0.006320400629192591,
-0.0179421529173851,
0.008375676348805428,
0.03753310441970825,
-0.006337575614452362,
0.03599880263209343,
0.020415352657437325,
-0.00017747502715792507,
0.018262751400470734,
-0.034372903406620026,
0.0064520756714046,
0.027205202728509903,
-0.04749460518360138,
-0.05463940650224686,
-0.023816002532839775,
-0.01196525152772665,
0.0010591251775622368,
0.018846701830625534,
-0.00999585073441267,
-0.025602202862501144,
-0.006079950835555792,
0.0647612065076828,
0.0014613064704462886,
-0.01645365171134472,
-0.0012480501318350434,
0.013854501768946648,
0.024411402642726898,
-0.01968255266547203,
-0.06247120723128319,
-0.04641830548644066,
0.028945602476596832,
0.035403404384851456,
0.008175301365554333,
-0.013636951334774494,
-0.014575852081179619,
0.05514320731163025,
0.031006604433059692,
0.01860625296831131,
-0.04387640580534935,
-0.02178935334086418,
0.06659320741891861,
0.030113503336906433,
0.015457501634955406,
-0.016064351424574852,
0.02736550383269787,
-0.029174603521823883,
-0.0037241128738969564,
-0.009675251320004463,
-0.007734476123005152,
-0.002012337790802121,
-0.008621850982308388,
0.0180681012570858,
0.021755002439022064,
-0.034098103642463684,
-0.012720951810479164,
0.032220304012298584,
0.006068500690162182,
-0.005264138337224722,
0.0221786517649889,
-0.015812451019883156,
0.032495103776454926,
0.025877002626657486,
-0.03405230492353439,
0.003675450338050723,
0.029495203867554665,
-0.014243802055716515,
0.008037900552153587,
-0.023495402187108994,
-0.05147920548915863,
-0.00411627534776926,
0.007539825979620218,
0.03290730342268944,
-0.05734160542488098,
-0.0413116030395031,
0.04804420471191406,
0.04646410420536995,
-0.030617304146289825,
0.002862500259652734,
0.017094852402806282,
-0.0033262253273278475,
0.0354263037443161,
0.01641930267214775,
0.001007600105367601,
-0.004170663189142942,
-0.03112110309302807,
-0.05743320658802986,
-0.03970860317349434,
-0.00016325197066180408,
0.0305028036236763,
-0.010076001286506653,
-0.04016660526394844,
-0.010276376269757748,
0.014552951790392399,
0.022304601967334747,
0.01601855270564556,
0.04266270622611046,
-0.01909860223531723,
0.005830913316458464,
0.04424280673265457,
-0.009537851437926292,
-0.04708240553736687,
-0.04181540384888649,
-0.005149638280272484,
0.008318426087498665,
0.042960405349731445,
-0.03180810436606407,
-0.008163850754499435,
-0.013339251279830933,
0.06641000509262085,
-0.017736051231622696,
0.027525803074240685,
-0.006349025759845972,
0.004849075339734554,
0.01731240190565586,
0.044975604861974716,
0.05651720613241196,
0.013991901651024818,
0.014278152026236057,
-0.004829037934541702,
-0.008123775944113731,
0.01672845147550106,
0.021491652354598045,
-0.03769340366125107,
-0.014484251849353313,
0.0239305030554533,
-0.016064351424574852,
-0.002036669058725238,
-0.04712820425629616,
0.057845406234264374,
0.02924330346286297,
0.03693770244717598,
-0.044792406260967255,
0.021297002211213112,
-0.037281204015016556,
-0.021926753222942352,
-0.0167742520570755,
0.02924330346286297,
0.02464040368795395,
0.01815970242023468,
-0.008427200838923454,
0.004900600761175156,
-0.038838405162096024,
0.022213002666831017,
0.03135010227560997,
-0.01856045238673687,
0.011759151704609394,
-0.012182801030576229,
0.027205202728509903,
-0.0012237188639119267,
0.009108476340770721,
-0.014976602047681808,
0.046006105840206146,
-0.04905180633068085,
-0.061784207820892334,
0.02562510222196579,
0.07117320597171783,
-0.02924330346286297,
0.006389100570231676,
-0.007917676120996475,
-0.02759450301527977,
0.024457203224301338,
-0.052257806062698364,
0.03680030256509781,
0.058349207043647766,
0.00371266296133399,
-0.03641100600361824,
-0.02777770347893238,
-0.03361720219254494,
-0.038014005869627,
0.007030300796031952,
-0.026106003671884537,
0.046624407172203064,
-0.005719275679439306,
0.05386080592870712,
-0.029861602932214737,
-0.04266270622611046,
-0.043853506445884705,
0.02271680347621441,
0.00618300074711442,
0.04167800396680832,
-0.058211807161569595,
0.015434601344168186,
0.008158125914633274,
0.010156150907278061,
-0.01963675208389759,
-0.018938302993774414,
-0.019568052142858505,
0.0064921509474515915,
-0.050196804106235504,
-0.008146676234900951,
0.03751020506024361,
0.013762901537120342,
-0.023014502599835396,
0.001999456435441971,
-0.0415177047252655,
0.018583351746201515,
0.05683780834078789,
0.02473200298845768,
-0.04133450612425804,
-0.052532605826854706,
0.006749775726348162,
0.006486425641924143,
0.04254820570349693,
-0.06737180799245834,
-0.004642975516617298,
-0.04046430438756943,
-0.03751020506024361,
-0.003520875470712781,
0.003314775414764881,
0.030869202688336372,
0.01466745138168335,
0.04083070531487465,
-0.004376763012260199,
-0.007574175950139761,
-0.02688460238277912,
0.013636951334774494,
-0.0015271438751369715,
0.000005163123205420561,
0.015583451837301254,
-0.0019221690017729998,
-0.0036382379475980997,
0.04053300619125366,
-0.025304503738880157,
-0.012892701663076878,
-0.036250703036785126,
0.019087152555584908,
-0.015217051841318607,
0.01084315124899149,
-0.030021904036402702,
-0.02603730373084545,
-0.00907985121011734,
-0.007763100787997246,
0.03819720447063446,
-0.031510405242443085,
-0.007997825741767883,
-0.04758620634675026,
-0.027182303369045258,
-0.014484251849353313,
0.010264926590025425,
-0.01628190279006958,
-0.0029655504040420055,
0.024938102811574936,
-0.00522120064124465,
0.014552951790392399,
-0.04664730653166771,
0.005390088073909283,
-0.01856045238673687,
-0.019911551848053932,
0.013476651161909103,
0.0031315754167735577,
0.046097707003355026,
0.023495402187108994,
0.01896120235323906,
-0.030960803851485252,
0.032540902495384216,
-0.04078490659594536,
-0.0286250039935112,
0.04241080582141876,
-0.009801201522350311,
-0.019247451797127724,
0.03686900436878204,
0.027251003310084343,
-0.002020925283432007,
0.020358102396130562,
0.02665560320019722,
0.026678502559661865,
0.007253576070070267,
0.011014901101589203,
0.01837725192308426,
0.021262653172016144,
0.05518900603055954,
0.026449503377079964,
0.048548005521297455,
0.013339251279830933,
0.02271680347621441,
-0.00023919768864288926,
-0.03336530551314354,
0.03405230492353439,
-0.01614450104534626,
0.002161187818273902,
0.013900301419198513,
-0.020369552075862885,
-0.020449701696634293,
0.008106600493192673,
-0.03980020433664322,
0.025877002626657486,
0.0038443380035459995,
0.010035926476120949,
-0.002048118971288204,
0.023449603468179703,
-0.039204806089401245,
-0.03199130296707153,
-0.06292920559644699,
-0.03112110309302807,
-0.04261690378189087,
0.02674720250070095,
-0.010207676328718662,
0.01691165193915367,
0.0129041513428092,
0.012938501313328743,
-0.006360475905239582,
-0.002103937789797783,
0.016155952587723732,
-0.0034292754717171192,
-0.03327370434999466,
0.04431150481104851,
-0.00022059143520891666,
0.013476651161909103,
-0.005825188010931015,
0.004030400421470404,
0.03689190372824669,
0.02951810322701931,
-0.00905695091933012,
-0.003752738004550338,
0.0005538937984965742,
0.04699080437421799,
-0.020678702741861343,
0.04280010610818863,
-0.003400650341063738,
-0.001973693957552314,
-0.01346520148217678,
0.0018649189732968807,
-0.021251201629638672,
-0.008736350573599339,
0.011392751708626747,
-0.02142295241355896,
0.013682751916348934,
-0.01896120235323906,
-0.0769898071885109,
0.027113603428006172,
0.017106302082538605,
-0.021892402321100235,
-0.002563368994742632,
-0.020987851545214653,
0.053952407091856,
-0.02402210235595703,
0.0061143008060753345,
-0.004645837936550379,
0.01167327631264925,
0.0736922100186348,
0.009549301117658615,
-0.019522251561284065,
-0.02464040368795395,
0.007511200848966837,
0.006990225985646248,
-0.007161975838243961,
0.014541502110660076,
0.013362151570618153,
0.025739602744579315,
0.0026034440379589796,
0.01469035167247057,
-0.006412000861018896,
-0.015468952246010303,
-0.010448126122355461,
-0.00495498813688755,
-0.015606352128088474,
0.01236600149422884,
0.026632703840732574,
-0.03382330387830734,
-0.005032275803387165,
0.0007166985305957496,
-0.003008487867191434,
-0.0323806032538414,
-0.025648003444075584,
0.02825860306620598,
-0.028602102771401405,
-0.0017604377353563905,
0.0035638129338622093,
-0.014495701529085636,
0.0074425009079277515,
0.038838405162096024,
-0.015331551432609558,
-0.012595001608133316,
-0.010677126236259937,
-0.010665676556527615,
0.01332780160009861,
0.006016975734382868,
0.00020323751959949732,
0.014461351558566093,
-0.021617602556943893,
0.00034958284231834114,
-0.018972652032971382,
-0.02285420335829258,
0.005017963238060474,
0.0006590906996279955,
-0.0137285515666008,
0.028418904170393944,
-0.04499850422143936,
-0.03187680244445801,
-0.02876240387558937,
-0.030892103910446167,
0.01089467667043209,
-0.0030571504030376673,
-0.003346262965351343,
0.01712920144200325,
0.03331950306892395,
-0.024342702701687813,
-0.006354750599712133,
0.021033652126789093,
-0.007711575832217932,
0.002467475365847349,
0.0276861023157835,
0.01917875185608864,
-0.008931000716984272,
-0.03574690595269203,
0.026861703023314476,
0.012308751232922077,
0.006646725814789534,
0.003452175296843052,
0.023587003350257874,
0.01124962605535984,
-0.03336530551314354,
0.023186253383755684,
0.029770003631711006,
-0.021319901570677757,
0.008404300548136234,
-0.03922770544886589,
0.003686900483444333,
0.024090802296996117,
0.006383375730365515,
0.024434302002191544,
-0.0046601505018770695,
0.011226726695895195,
0.03036540374159813,
0.00768295070156455,
0.00578225078061223,
0.008158125914633274,
0.018617702648043633,
-0.03576980531215668,
0.03031960316002369,
0.010648501105606556,
0.019625302404165268,
-0.00993287656456232,
0.027182303369045258,
-0.009308851324021816,
0.05129600688815117,
-0.02562510222196579,
0.055372204631567,
0.004027538001537323,
0.01386595144867897,
0.011261076666414738,
0.0014498564414680004,
-0.013110251165926456,
-0.027022002264857292,
0.019064251333475113,
0.01788490265607834,
0.006801300682127476,
-0.020426802337169647,
-0.031281404197216034,
-0.005295625422149897,
0.018148252740502357,
-0.005493137985467911,
-0.012995751574635506,
-0.0006129328976385295,
-0.039685703814029694,
-0.008770701475441456,
-0.01415220182389021,
0.015125451609492302,
-0.00892527587711811,
-0.00618300074711442,
-0.004934950731694698,
-0.027090704068541527,
-0.008077976293861866,
-0.040899403393268585,
-0.006635275669395924,
0.010327900759875774,
0.04499850422143936,
-0.018926851451396942,
-0.022533603012561798,
0.02482360228896141,
-0.0019107189727947116,
0.00905695091933012,
-0.007579900790005922,
0.03528890386223793,
-0.0153659014031291,
-0.024342702701687813,
-0.008742076344788074,
-0.02468620240688324,
0.01762155257165432,
-0.03382330387830734,
-0.014644552022218704,
-0.009537851437926292,
0.041746705770492554,
-0.01115802675485611,
0.0018019439885392785,
0.012824001722037792,
-0.015766652300953865,
-0.0005224063061177731,
-0.018858151510357857,
0.0717686116695404,
-0.0021526003256440163,
-0.04996780678629875,
0.054181408137083054,
-0.0014040564419701695,
0.020415352657437325,
-0.013407951220870018,
-0.012262951582670212,
-0.05921940505504608,
0.038128502666950226,
0.009200075641274452,
-0.00043187974370084703,
-0.02473200298845768,
-0.03180810436606407,
-0.01485065184533596,
0.0018520377343520522,
-0.001426956383511424,
-0.026197602972388268,
0.0007456813473254442,
0.0017747501842677593,
0.015468952246010303,
0.03217450529336929,
0.0074310507625341415,
0.024251103401184082,
0.017965052276849747,
-0.04964720457792282,
0.026632703840732574,
0.0069501507095992565,
-0.016167402267456055,
0.011409926228225231,
0.010104626417160034,
0.010854600928723812,
0.006308950949460268,
0.0029598253313452005,
-0.014575852081179619,
0.01538880169391632,
-0.0396399050951004,
0.004883425775915384,
0.01811390183866024,
0.0031344378367066383,
-0.005521763116121292,
0.034464504569768906,
-0.011862201616168022,
0.00836422573775053,
0.0030771878082305193,
0.005862400867044926,
0.026266302913427353,
-0.004285162780433893,
0.010385151021182537,
-0.01614450104534626,
0.009285951033234596,
0.04307490587234497,
-0.014083501882851124,
-0.003463625442236662,
0.013316351920366287,
-0.008736350573599339,
-0.017243701964616776,
-0.012812551110982895,
-0.002092487644404173,
0.017415452748537064,
-0.014072051271796227,
-0.008089425973594189,
0.018663501366972923,
-0.002451731590554118,
0.005644850432872772,
-0.016923101618885994,
-0.022922903299331665,
0.0026921816170215607,
-0.033205002546310425,
0.026586903259158134,
0.006681075785309076,
0.015010952018201351,
0.024938102811574936,
-0.07360060513019562,
0.009709601290524006,
-0.006915800739079714,
0.04096810519695282,
0.019705452024936676,
0.015823902562260628,
0.032632503658533096,
0.02360990270972252,
0.011621750891208649,
0.01274385116994381,
0.0019307564944028854,
0.00014661368913948536,
0.013934651389718056,
-0.04602900519967079,
0.007230675779283047,
-0.04135740548372269,
-0.004385350737720728,
-0.043189406394958496,
0.04199860617518425,
0.004164937883615494,
-0.0137285515666008,
0.013030101545155048,
0.018984101712703705,
0.07346320897340775,
-0.004176388029009104,
0.03313630446791649,
-0.021262653172016144,
0.03176230192184448,
-0.02120540291070938,
-0.033525604754686356,
-0.03533470258116722,
-0.009566476568579674,
0.0023358003236353397,
0.029976103454828262,
-0.0031144004315137863,
-0.02066725306212902,
0.010997726581990719,
0.004708813037723303,
0.004992200527340174,
0.013110251165926456,
0.026999102905392647,
-0.0013146032579243183,
0.020003153011202812,
0.004391075577586889,
-0.05129600688815117,
-0.016316251829266548,
-0.036250703036785126,
-0.009451976045966148,
-0.019419202581048012,
-0.038311704993247986,
0.010665676556527615,
-0.013476651161909103,
0.012262951582670212,
-0.011793501675128937,
0.014518601819872856,
-0.027938002720475197,
0.040624603629112244,
0.009509226307272911,
0.02880820259451866,
0.021629052236676216,
0.01082025095820427,
-0.00022613751934841275,
0.013098801486194134,
-0.010322175920009613,
0.01089467667043209,
0.015457501634955406,
0.00713335070759058,
0.0056419880129396915,
-0.010133251547813416,
-0.007219225633889437,
-0.0018477439880371094,
-0.005481688305735588,
-0.04355580359697342,
0.019980251789093018,
-0.029403602704405785,
0.00863330066204071,
-0.03478510305285454,
-0.0030113502871245146,
-0.03609040379524231,
0.03508280590176582,
0.02186950296163559,
-0.020873352885246277,
0.00905695091933012,
0.007946301251649857,
-0.013316351920366287,
-0.0008573188679292798,
-0.011077876202762127,
-0.008450101129710674,
0.0051210131496191025,
-0.0007564157131128013,
0.046945005655288696,
-0.010677126236259937,
-0.031418804079294205,
-0.026953302323818207,
0.008020726032555103,
-0.004605763126164675,
-0.02231605350971222,
0.015480401925742626,
0.006423450540751219,
0.003340537892654538,
0.033548504114151,
-0.02262520231306553,
-0.04566260427236557,
-0.005656300578266382,
-0.005189713090658188,
0.004359588027000427,
0.05335700511932373,
0.0046916380524635315,
0.01100345142185688,
-0.021365702152252197,
0.003649687860161066,
-0.006612375844269991,
0.007688676007091999,
-0.032495103776454926,
0.04243370518088341,
0.0029941753018647432,
0.023999202996492386,
-0.026220502331852913,
-0.027296803891658783,
-0.00793485064059496,
0.034098103642463684,
-0.0031258503440767527,
-0.02093060314655304,
-0.0008387126144953072,
-0.003039975417777896,
0.002796662738546729,
-0.016362052410840988,
0.001684581395238638,
0.02259085327386856,
-0.009743951261043549,
0.009314576163887978,
-0.015755202621221542,
-0.00371266296133399,
-0.013785801827907562,
-0.015606352128088474,
0.010608426295220852,
0.03281570225954056,
0.04149480536580086,
-0.010184776037931442,
-0.017987951636314392,
0.008753526024520397,
-0.016396401450037956,
-0.02011765167117119,
0.03448740392923355,
-0.010568351484835148,
-0.018148252740502357,
-0.02075885236263275,
-0.022888552397489548,
-0.005378637928515673,
-0.026220502331852913,
0.032449305057525635,
0.02482360228896141,
0.016350602731108665,
0.03696060553193092,
-0.02491520345211029,
0.01914440281689167,
0.02213285304605961,
0.029266202822327614,
-0.00008207325299736112,
0.013407951220870018,
-0.020770302042365074,
0.02867080271244049,
-0.028922703117132187,
-0.023770201951265335,
-0.022980153560638428,
-0.006578025873750448,
-0.003801400540396571,
-0.031418804079294205,
0.034601904451847076,
0.009205801412463188,
0.008432925678789616,
-0.03810560330748558,
0.05381500720977783,
0.0015529064694419503,
-0.04218180477619171,
0.02548770233988762,
0.004479812923818827,
0.014072051271796227,
0.033159203827381134,
0.030479904264211655,
-0.014014801941812038,
-0.0017404002137482166,
0.0203008521348238,
0.014564401470124722,
0.015400251373648643,
-0.016739901155233383,
0.04149480536580086,
0.004714537877589464,
-0.003941663075238466,
-0.005830913316458464,
0.00937182642519474,
0.017518501728773117,
0.029357803985476494,
0.028991403058171272,
-0.0015758064109832048,
0.004362450446933508,
0.00039001565892249346,
0.024525903165340424,
-0.01597275212407112,
-0.00865620095282793,
-0.03318210318684578,
0.03416680544614792,
0.024182403460144997,
-0.01330490130931139,
-0.018766552209854126,
0.02312900312244892,
0.02651820331811905,
-0.05642560496926308,
-0.030388303101062775,
0.06819620728492737,
-0.015606352128088474,
0.04763200506567955,
-0.018491752445697784,
-0.0051009757444262505,
0.03331950306892395,
-0.018091002479195595,
0.01276675146073103,
-0.015732301399111748,
-0.056379806250333786,
-0.007866150699555874,
0.017415452748537064,
-0.008507351391017437,
0.027251003310084343,
-0.01682005263864994,
-0.020461153239011765,
0.006841375958174467,
0.010430951602756977,
-0.005971175618469715,
-0.00453992560505867,
0.006177275907248259,
-0.02979290299117565,
0.00018391564663033932,
0.009011151269078255,
0.05674620717763901,
0.006663900800049305,
0.010906126350164413,
0.0013639813987538218,
-0.006847100798040628,
0.012262951582670212,
-0.010116076096892357,
0.02603730373084545,
0.003976013045758009,
0.0012272970052435994,
-0.019155852496623993,
-0.015171252191066742,
-0.009280226193368435,
0.07126481086015701,
-0.013385051861405373,
-0.0003925203636754304,
-0.024617502465844154,
-0.006154375616461039,
0.013568251393735409,
0.000640842248685658,
-0.007247850764542818,
0.05317380651831627,
-0.03251800313591957,
0.020598553121089935,
-0.025556402280926704,
0.010768726468086243,
0.008587501011788845,
-0.0015099688898772001,
-0.02196110226213932,
-0.0051925755105912685,
0.007373800966888666,
-0.014621651731431484,
0.0064807008020579815,
-0.01754140295088291,
0.03505990281701088,
-0.030754704028367996,
-0.0009904251201078296,
0.023472502827644348,
-0.013270551338791847,
-0.0051725381053984165,
-0.008003550581634045,
0.021136702969670296,
-0.004909188020974398,
0.018045201897621155,
0.03970860317349434,
0.01597275212407112,
-0.020610002800822258,
0.010522550903260708,
-0.016785701736807823,
0.0019307564944028854,
0.03858650475740433,
0.0032603878062218428,
0.0019321877043694258,
-0.007786001078784466,
-0.022980153560638428,
-0.010608426295220852,
0.008438650518655777,
-0.0025290190242230892,
-0.009703876450657845,
0.010367976501584053,
-0.020197803154587746,
-0.0031144004315137863,
-0.03421260416507721,
-0.005475963000208139,
0.01154160127043724,
-0.006251700688153505,
-0.037052202969789505,
0.025327403098344803,
0.026999102905392647,
-0.050517406314611435,
-0.008816501125693321,
0.0018620564369484782,
-0.0016373501857742667,
-0.028945602476596832,
-0.032632503658533096,
0.008261175826191902,
-0.0070016756653785706,
-0.04616640508174896,
0.0328386053442955,
0.014781951904296875,
-0.004468363244086504,
0.00013203283015172929,
0.010969101451337337,
-0.0012630783021450043,
-0.015617801807820797,
0.003054287750273943,
-0.006755500566214323,
0.0021225439850240946,
0.019648201763629913,
0.0047861007042229176,
-0.013488101772964,
-0.021812252700328827,
-0.02919750288128853,
0.01936195231974125,
0.002175500150769949,
0.003984600305557251,
0.014198001474142075,
-0.006074225530028343,
-0.014243802055716515,
0.0016731314826756716,
0.007104726042598486,
0.02123975194990635,
0.030205102637410164,
0.02562510222196579,
-0.024159502238035202,
0.013247651979327202,
0.015125451609492302,
0.014907902106642723,
0.019510801881551743,
0.029586803168058395,
0.00741387577727437,
0.016178851947188377,
-0.002971275243908167,
0.011679001152515411,
-0.01506820134818554,
-0.030113503336906433,
-0.02110235206782818,
0.039685703814029694,
-0.02285420335829258,
0.011896551586687565,
0.046441204845905304,
0.004871975630521774,
0.0026649876963347197,
0.02106800302863121,
-0.015033851377665997,
-0.027938002720475197,
0.029312003403902054,
-0.02196110226213932,
0.016316251829266548,
0.007871875539422035,
-0.019533703103661537,
-0.004422563128173351,
0.004934950731694698,
0.012640801258385181,
-0.0009603688376955688,
0.023003052920103073,
-0.008530250750482082,
-0.007333725690841675,
0.007116175722330809,
-0.05267000570893288,
0.0009288813453167677,
0.002423106459900737,
-0.007711575832217932,
-0.0033777502831071615,
-0.015285751782357693,
0.0016301939031109214,
0.03636520355939865,
0.023541202768683434,
0.006755500566214323,
0.01694600284099579,
-0.012595001608133316,
-0.005467375740408897,
-0.0016774252289906144,
-0.0038758255541324615,
0.0016101563815027475,
0.021388603374361992,
-0.025258703157305717,
0.01471325196325779,
0.005332838278263807,
0.007121901027858257,
-0.016579601913690567,
-0.011850751005113125,
0.008461550809442997,
-0.00811805110424757,
0.010659950785338879,
-0.007906225509941578,
-0.009829825721681118,
-0.02370150201022625,
0.004084787797182798,
0.005415850784629583,
-0.00820392556488514,
0.011255350895226002,
0.0035752628464251757,
0.01082597579807043,
0.030960803851485252,
-0.0075684511102736,
0.003841475350782275,
-0.018354352563619614,
0.005341425538063049,
-0.0293349027633667,
0.02567090280354023,
-0.02219010330736637,
0.006658175960183144,
0.0012494813418015838,
-0.00742532592266798,
0.002491806633770466,
-0.03274700418114662,
0.0014484251150861382,
0.010946201160550117,
0.024800702929496765,
-0.001370422076433897,
-0.022419102489948273,
-0.0047116754576563835,
-0.011215276084840298,
0.036113303154706955,
-0.028189903125166893,
0.0069501507095992565,
0.03810560330748558,
-0.01731240190565586,
0.0035895754117518663,
-0.02020925283432007,
-0.027159404009580612,
0.02048405259847641,
-0.007579900790005922,
-0.015675051137804985,
0.01703760214149952,
0.02156035229563713,
0.007871875539422035,
0.004577137995511293,
-0.015846801921725273,
0.017507052049040794,
-0.024411402642726898,
-0.01605290174484253,
0.0027064939495176077,
0.021892402321100235,
0.019602403044700623,
0.03767050430178642,
-0.01976270228624344,
0.0025619377847760916,
0.013900301419198513,
-0.01031072624027729,
-0.010974826291203499,
-0.011501526460051537,
-0.021033652126789093,
-0.016923101618885994,
0.012423251755535603,
0.010253475978970528,
-0.007350900676101446,
-0.007665775716304779,
0.0005771516007371247,
0.03947960585355759,
-0.015468952246010303,
0.04138030484318733,
0.008089425973594189,
0.030800502747297287,
-0.050792206078767776,
-0.025693802163004875,
0.004983613267540932,
0.018228402361273766,
0.001474187709391117,
0.0035437755286693573,
0.06425740569829941,
0.006978775840252638,
0.012640801258385181,
-0.011593126691877842,
0.0015944127226248384,
-0.009646626189351082,
-0.004038988146930933,
0.019980251789093018,
-0.01485065184533596,
-0.002792369108647108,
0.03952540457248688,
0.04128870368003845,
0.01586970128118992,
-0.02209850214421749,
0.02754870243370533,
-0.012709501199424267,
0.03288440406322479,
0.02548770233988762,
0.011953801847994328,
-0.006497875787317753,
-0.03153330460190773,
0.0011464314302429557,
-0.0016946002142503858,
0.007602801080793142,
0.006016975734382868,
-0.03993760421872139,
-0.005524625536054373,
0.022476352751255035,
0.01637350209057331,
0.004889150615781546,
-0.026586903259158134,
0.0099099762737751,
-0.03054860420525074,
-0.039914704859256744,
0.0008079407270997763,
-0.002589131472632289,
-0.028281502425670624,
0.006549400743097067,
-0.002755156485363841,
0.035632405430078506,
0.01055117603391409,
-0.013430851511657238,
-0.036067504435777664,
0.04142610356211662,
0.011490076780319214,
-0.01574375107884407,
-0.02075885236263275,
-0.012675151228904724,
-0.0007299375720322132,
-0.03899870440363884,
-0.007974926382303238,
-0.0056105004623532295,
-0.015514751896262169,
0.02754870243370533,
0.01649945229291916,
0.019442101940512657,
0.05363180488348007,
0.009263050742447376,
-0.01538880169391632,
-0.041563503444194794,
-0.00910275150090456,
0.04522750526666641,
-0.04195280373096466,
-0.022865653038024902,
0.017472701147198677,
-0.024205302819609642,
-0.0302738044410944,
-0.01319040171802044,
0.024136602878570557,
0.03267830237746239,
0.01752995140850544,
0.06270020455121994,
0.011203826405107975,
-0.04312070459127426,
0.0004580000531859696,
0.017827652394771576,
0.0356782041490078,
-0.006337575614452362,
0.017369652166962624,
0.002745137782767415,
-0.02272825315594673,
-0.00796347577124834,
0.015858251601457596,
-0.0014183688908815384,
-0.034601904451847076,
-0.02599150314927101,
0.00523265078663826,
-0.007860425859689713,
-0.013980451971292496,
-0.016247551888227463,
-0.005604775622487068,
0.022109951823949814,
-0.0028038190212100744,
-0.025693802163004875,
-0.05578440800309181,
-0.021583251655101776,
0.0010705750901252031,
-0.03206000477075577,
-0.015354451723396778,
-0.032586704939603806,
-0.016339151188731194,
-0.03233480453491211,
-0.0099099762737751,
0.01878945156931877,
0.019739802926778793,
-0.012434701435267925,
0.01068857591599226,
-0.001963675254955888,
-0.0006873579113744199,
-0.01775895245373249,
-0.015846801921725273,
-0.02191530168056488,
-0.014988051727414131,
0.023151902481913567,
-0.02374730259180069,
0.001684581395238638,
-0.060089606791734695,
-0.014656001701951027,
0.035311803221702576,
-0.01811390183866024,
-0.030892103910446167,
0.0031716504599899054,
-0.0007535532349720597,
0.018949752673506737,
-0.01127252634614706,
0.010854600928723812,
-0.004614350385963917,
-0.033663004636764526,
0.013121701776981354,
0.0021955377887934446,
0.002477494068443775,
0.00550172571092844,
0.005415850784629583,
-0.01480485126376152,
0.012675151228904724,
0.013430851511657238,
-0.033434003591537476,
-0.012640801258385181,
0.015262851491570473,
-0.017140651121735573,
0.01802230253815651,
0.01717500202357769,
-0.027159404009580612,
-0.0019035626901313663,
-0.008639026433229446,
-0.0037870879750698805,
0.03574690595269203,
0.050792206078767776,
-0.003649687860161066,
0.029861602932214737,
0.030296703800559044,
0.054502006620168686,
-0.0005331406719051301,
0.017907802015542984,
0.05299060791730881,
-0.04440310597419739,
-0.01680860109627247,
-0.012114101089537144,
-0.000547810981515795,
-0.016923101618885994,
0.0037613254971802235,
-0.008209651336073875,
-0.019797053188085556,
-0.0004941390943713486,
-0.01851465180516243,
0.00563626317307353,
0.00823255069553852,
0.01843450218439102,
-0.010350801050662994,
0.025831203907728195,
-0.028876902535557747,
0.026495303958654404,
-0.009795475751161575,
-0.000496643828228116,
-0.008077976293861866,
-0.021548902615904808,
-0.018571902066469193,
0.022029802203178406,
0.01628190279006958,
0.011713351123034954,
0.011450001038610935,
0.02231605350971222,
-0.010585526004433632,
0.018755102530121803,
-0.015549101866781712,
0.0009603688376955688,
0.03744150325655937,
-0.012778201140463352,
-0.014896451495587826,
0.013648401945829391,
0.0009947188664227724,
-0.018274202942848206,
0.02356410212814808,
0.04025820642709732,
-0.004788963124155998,
-0.019293252378702164,
-0.040006306022405624,
0.011146576143801212,
-0.012102651409804821,
-0.0011349814012646675,
0.12082041054964066,
-0.06517340987920761,
-0.008598950691521168,
0.00509811332449317,
0.005965450778603554,
0.0027379815001040697,
0.013075901195406914,
0.016579601913690567,
0.011369851417839527,
-0.01632770150899887,
0.008060800842940807,
-0.0027751941233873367,
0.007030300796031952,
0.02693040296435356,
0.022464903071522713,
-0.028991403058171272,
-0.023151902481913567,
0.05267000570893288,
0.00924015138298273,
0.0161903016269207,
0.0302738044410944,
0.00945770088583231,
-0.0276861023157835,
0.0004876985040027648,
-0.004903463181108236,
0.027709003537893295,
-0.022476352751255035,
-0.033250804990530014,
0.01386595144867897,
-0.0373041033744812,
0.00964090134948492,
-0.009303126484155655,
0.0203008521348238,
-0.01797650195658207,
-0.0009231563308276236,
0.014518601819872856,
0.002012337790802121,
-0.020873352885246277,
-0.0323806032538414,
0.017094852402806282,
0.01788490265607834,
0.002846756484359503,
-0.00522120064124465,
0.030021904036402702,
0.0349683053791523,
0.033434003591537476,
-0.034510303288698196,
0.01294995192438364,
0.030159303918480873,
-0.022476352751255035,
-0.009085576049983501,
-0.025648003444075584,
0.037853702902793884,
-0.031464602798223495,
-0.000052240629884181544,
0.005850950721651316,
0.03391490504145622,
-0.003801400540396571,
-0.011278251186013222,
-0.040624603629112244,
0.00024331253371201456,
-0.004791825544089079,
0.012308751232922077,
0.011656101793050766,
0.0354263037443161
] | 2024-07-18 | 66 | 39019005 | [
"anti-tumor immunotherapies",
"tumor growth",
"accelerated tumor growth",
"anti-tumor immune responses",
"anti-cancer immunotherapies",
"selective PARP11 inhibitor",
"induce PARP11",
"solid tumors",
"PARP11",
"immunosuppressive TME",
"immunosuppressive activities",
"immune checkpoint blockade",
"chimeric antigen receptor",
"TI-Treg cell numbers",
"TME",
"poor responses",
"ICB",
"adoptive transfer",
"immunotherapies",
"TI-Treg activities",
"human patients",
"tumor-bearing mice",
"Tumor-derived factors",
"TI-Treg",
"Tumor-infiltrating regulatory T cells",
"TI-Tregs",
"ITK7",
"the tumor microenvironment",
"adenosine",
"E2"
] | [
"ITK7",
"PARP11",
"PARP11 inhibitor",
"Treg cells",
"immunotherapy",
"tumor microenvironment"
] | 0 | 10.1016/j.xcrm.2024.101649
10.1146/annurev-pathol-042020-042741
10.1126/science.aar4060
10.1111/imr.13273
10.1016/j.ccr.2012.02.022
10.1126/science.aaa6204
10.1038/s41571-018-0142-8
10.1038/nrclinonc.2015.209
10.1038/83784
10.1038/ni904
10.1158/2326-6066.CIR-16-0193
10.1016/j.cell.2008.05.009
10.3389/fimmu.2013.00212
10.1111/imm.13067
10.1007/978-3-030-49270-0_6
10.1016/j.coi.2020.07.001
10.1038/nm1093
10.1038/nm.4086
10.1016/j.immuni.2016.01.013
10.1073/pnas.1822001116
10.1038/s41591-022-01960-7
10.1038/s41591-022-01959-0
10.1016/j.trecan.2022.06.008
10.1016/j.ccell.2023.02.014
10.1002/eji.202048992
10.1038/s41467-021-27574-0
10.1038/s43018-022-00383-0
10.1016/j.celrep.2015.12.045
10.1038/s41564-019-0582-7
10.1038/s41564-019-0428-3
10.1038/sj.onc.1207389
10.1007/s00109-022-02215-1
10.1038/s41590-021-00889-2
10.1016/j.immuni.2013.07.019
10.1089/jir.2012.0117
10.1371/journal.ppat.1006985
10.1158/2326-6066.CIR-22-0295
10.1016/j.chembiol.2018.09.011
10.1038/s41401-023-01079-6
10.1093/jleuko/qiae030
10.1016/j.cell.2016.02.065
10.1038/s41586-023-06837-4
10.1095/biolreprod.114.123661
10.1038/nature12428
10.1016/j.cell.2017.05.005
10.3389/fimmu.2013.00152
10.1038/s41571-019-0175-7
10.1126/science.1202947
10.1038/s41590-018-0280-2
10.1172/JCI66375
10.1016/j.celrep.2017.06.062
10.1111/imr.12173
10.1158/0008-5472.CAN-18-1351
10.1038/414916a
10.1038/s41419-018-1298-y
10.1038/s41467-021-22033-2
10.1182/blood-2011-06-359745
10.1038/s41388-020-01424-7
10.1038/s43018-020-0064-0
10.1016/j.cbpa.2023.102402
10.1101/gad.334516.119
10.1016/j.ccell.2021.06.018
10.1016/j.immuni.2018.06.006
10.1093/nar/gkaa407 | [
"Basavaraja",
"Zhang",
"Holczbauer",
"Lu",
"Radaelli",
"Assenmacher",
"George",
"Nallamala",
"Beiting",
"Meyer-Ficca",
"Meyer",
"Guo",
"Fan",
"Modzelewski",
"Spiegelman",
"Cohen",
"Fuchs"
] | [
"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Veterinary Clinical and Life Sciences, College of Veterinary Medicine, Utah State University, Logan, UT 84332, USA.",
"Department of Veterinary Clinical and Life Sciences, College of Veterinary Medicine, Utah State University, Logan, UT 84332, USA.",
"Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Departments of Radiation Oncology and of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.",
"Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.",
"Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA.",
"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: [email protected]."
] | [
"39019005",
"33197221",
"29567705",
"37694970",
"22439926",
"25838376",
"30523282",
"26598942",
"11138001",
"12612578",
"27590281",
"18510923",
"23898333",
"31087644",
"33119878",
"32810642",
"15322536",
"27111280",
"26872697",
"31028147",
"36097223",
"36097221",
"35853825",
"36917950",
"33302322",
"34907192",
"35637402",
"26774478",
"31649358",
"30988430",
"15021890",
"35672519",
"33664518",
"23954131",
"23570388",
"29672594",
"36255418",
"30344052",
"37055532",
"38334307",
"26997480",
"38093010",
"25673562",
"23913274",
"28552348",
"23801990",
"30705439",
"21474713",
"30643268",
"24812664",
"28723561",
"24712466",
"30181177",
"11780065",
"30718502",
"33741967",
"21832278",
"32807917",
"34124690",
"37801755",
"32029455",
"34375612",
"28196594",
"29958801",
"25516281",
"32442275"
] | [] | 9.462288 | 5.834893 |
39018097 | 717 | Regulatory Considerations for Genome-Edited T-cell Therapies. | Methods to engineer the genomes of human cells for therapeutic intervention continue to advance at a remarkable pace. Chimeric antigen receptor-engineered T lymphocytes have pioneered the way for these therapies, initially beginning with insertions of chimeric antigen receptor transgenes into T-cell genomes using classical gene therapy vectors. The broad use of clustered regularly interspaced short palindromic repeats (CRISPR)-based technologies to edit endogenous genes has now opened the door to a new era of precision medicine. To add complexity, many engineered cellular therapies under development integrate gene therapy with genome editing to introduce novel biological functions and enhance therapeutic efficacy. Here, we review the current state of scientific, translational, and regulatory oversight of gene-edited cell products. | [
0.027534952387213707,
0.03731067478656769,
0.03449433669447899,
0.027837535366415977,
-0.03482019528746605,
-0.0015143642667680979,
0.024136725813150406,
0.036193449050188065,
-0.01585063710808754,
0.00522826611995697,
0.018957920372486115,
-0.03181765228509903,
0.013208864256739616,
0.02527722716331482,
0.0015420039417222142,
-0.052137188613414764,
0.03793911635875702,
-0.03526242822408676,
0.01857387274503708,
0.008256994187831879,
0.02800046280026436,
0.04075545445084572,
0.004052851814776659,
0.02014497108757496,
-0.02042427845299244,
-0.00014901795657351613,
0.023787593469023705,
0.03782273828983307,
-0.007174682337790728,
-0.017107514664530754,
-0.01929541490972042,
-0.01589718833565712,
0.0072794221341609955,
-0.0033400387037545443,
-0.021413488313555717,
0.05423198640346527,
0.043106283992528915,
0.02227468229830265,
-0.014896339736878872,
-0.004611464682966471,
0.033004701137542725,
-0.02340354584157467,
-0.006837187334895134,
0.07606443762779236,
-0.0499492883682251,
0.005897437687963247,
-0.023438459262251854,
-0.013185588642954826,
-0.0042099617421627045,
-0.0004902408691123128,
0.014651946723461151,
-0.002299913438037038,
-0.05735090747475624,
0.036100346595048904,
-0.06954728811979294,
0.055861275643110275,
-0.03568138927221298,
-0.005792697891592979,
-0.05455784499645233,
0.033772796392440796,
0.02502119541168213,
-0.016676917672157288,
0.03893996402621269,
-0.0025777651462703943,
-0.039940811693668365,
0.025905665010213852,
-0.04794759303331375,
-0.0009215655736625195,
0.015233835205435753,
0.018317842856049538,
0.014128247275948524,
-0.012208015657961369,
-0.030467670410871506,
-0.006546243093907833,
0.016653642058372498,
-0.01929541490972042,
0.022810019552707672,
0.05097341164946556,
0.040103740990161896,
-0.010700925253331661,
0.03267884626984596,
-0.023554837331175804,
0.011591214686632156,
-0.016583815217018127,
-0.05171823129057884,
-0.006226204335689545,
0.023461734876036644,
0.0018605877412483096,
-0.04236146807670593,
-0.04387437552213669,
-0.03747360408306122,
0.017177341505885124,
-0.049390677362680435,
0.06116809695959091,
-0.019760925322771072,
0.06321634352207184,
-0.011649402789771557,
-0.023100964725017548,
0.0506475567817688,
0.03765980899333954,
0.05730435624718666,
0.004468902014195919,
0.004541637841612101,
0.0068313684314489365,
0.04070890322327614,
-0.05730435624718666,
-0.030421119183301926,
0.02499791979789734,
0.03745032846927643,
-0.011370097286999226,
0.037101197987794876,
-0.006616069469600916,
-0.03125903755426407,
0.036170173436403275,
-0.013814027421176434,
-0.027790984138846397,
-0.014814875088632107,
-0.009892100468277931,
0.014011869207024574,
0.03854427859187126,
-0.015454952605068684,
0.02490481734275818,
0.03747360408306122,
-0.037054646760225296,
-0.008041695691645145,
-0.03882358595728874,
0.0314219668507576,
-0.022123392671346664,
-0.014174798503518105,
-0.033190906047821045,
0.02375268004834652,
0.014442467130720615,
0.01908593624830246,
0.004791849758476019,
-0.05474404990673065,
0.0031683817505836487,
0.02190227434039116,
0.03607707470655441,
-0.06642836332321167,
-0.014081696048378944,
0.003991753328591585,
-0.03246936574578285,
0.0002878528612200171,
0.0030810984317213297,
-0.02581256441771984,
-0.020947977900505066,
0.0007600915851071477,
0.061354298144578934,
-0.0314219668507576,
0.05367337539792061,
-0.048925165086984634,
0.042640771716833115,
0.04387437552213669,
-0.020040232688188553,
-0.011748324148356915,
-0.003555337432771921,
-0.023950520902872086,
0.058607786893844604,
-0.024834992364048958,
-0.02534705400466919,
-0.02206520363688469,
0.03130558878183365,
-0.03456416353583336,
-0.023217342793941498,
0.018166551366448402,
-0.04236146807670593,
-0.011818150989711285,
0.04380454868078232,
-0.051857881247997284,
-0.027092717587947845,
-0.042570944875478745,
-0.03160817176103592,
-0.03284177556633949,
-0.0021515318658202887,
-0.03198057785630226,
-0.02340354584157467,
0.011492293328046799,
-0.0023130059707909822,
-0.06056293100118637,
-0.04701657220721245,
-0.008414104580879211,
0.026254799216985703,
-0.03167799860239029,
0.03207368031144142,
0.004818034823983908,
0.00006823549483669922,
-0.01269680168479681,
0.005626859609037638,
-0.043036457151174545,
-0.046388134360313416,
0.007651830557733774,
-0.007954413071274757,
0.03207368031144142,
-0.010311060585081577,
0.018632061779499054,
0.010066667571663857,
0.03758998215198517,
0.013336879201233387,
0.0504148006439209,
-0.07066451013088226,
0.042733874171972275,
-0.009211291559040546,
-0.03286505118012428,
-0.02830304577946663,
-0.04159337282180786,
-0.04387437552213669,
-0.02492809295654297,
0.03242281451821327,
-0.009077456779778004,
0.01617649383842945,
0.042850252240896225,
-0.0058043356984853745,
0.018073448911309242,
0.021320385858416557,
-0.03786928951740265,
-0.01281317975372076,
0.007756570819765329,
0.014547206461429596,
0.00582179194316268,
-0.0027552410028874874,
-0.03435468301177025,
-0.003988844342529774,
-0.0027159634046256542,
0.036240000277757645,
-0.02176262065768242,
-0.007099037058651447,
-0.0569785013794899,
-0.021366937085986137,
0.015722621232271194,
0.004140134900808334,
0.02274019457399845,
-0.008827244862914085,
0.009851368144154549,
-0.07052485644817352,
-0.0020031502936035395,
0.019958768039941788,
0.015233835205435753,
-0.022612178698182106,
0.05991121754050255,
-0.02869872935116291,
0.004567822907119989,
-0.005263179540634155,
0.03537880629301071,
-0.010584548115730286,
-0.040220119059085846,
0.027046166360378265,
-0.00432052044197917,
-0.07424894720315933,
0.03146851807832718,
0.010939499363303185,
-0.007710019592195749,
0.018038537353277206,
0.03440123423933983,
-0.013022659346461296,
0.039777882397174835,
0.030421119183301926,
0.010695106349885464,
0.004128497093915939,
0.030816802754998207,
0.007768208626657724,
0.0144773805513978,
-0.013802389614284039,
-0.03533225506544113,
0.010107398964464664,
-0.033074527978897095,
0.006424046587198973,
0.017898883670568466,
0.04231491684913635,
0.02229795791208744,
-0.03824169561266899,
0.01112570334225893,
0.0037502699997276068,
0.01763121411204338,
-0.05655954033136368,
-0.06358875334262848,
-0.015117457136511803,
-0.0019071388524025679,
0.02246088720858097,
-0.012103276327252388,
0.048738960176706314,
-0.04790104180574417,
0.016991138458251953,
0.007872948423027992,
-0.022658729925751686,
-0.04229164123535156,
-0.0040819463320076466,
-0.00037604529643431306,
0.023042775690555573,
-0.008064971305429935,
-0.07238689810037613,
0.02234450913965702,
0.008745781145989895,
-0.005958535708487034,
-0.009007630869746208,
0.009845549240708351,
0.024578960612416267,
-0.009228748269379139,
0.01631614752113819,
-0.04049942269921303,
0.0060458192601799965,
-0.004175048321485519,
0.003872466506436467,
-0.006848825141787529,
-0.033912450075149536,
-0.03726412355899811,
0.027860810980200768,
-0.04513125494122505,
-0.04855275899171829,
0.048738960176706314,
0.016909673810005188,
0.026883238926529884,
-0.016118304803967476,
0.02865217812359333,
-0.049157921224832535,
0.012208015657961369,
0.0036309827119112015,
0.023054413497447968,
-0.04129079356789589,
-0.013988594524562359,
-0.030118536204099655,
-0.061866361647844315,
0.016374336555600166,
-0.02021479792892933,
-0.0067033530212938786,
-0.0124291330575943,
-0.003308034734800458,
0.011695954017341137,
-0.007529634051024914,
0.05921294912695885,
-0.023205704987049103,
0.006749903783202171,
-0.011765780858695507,
0.064240463078022,
0.009508054703474045,
0.015082543715834618,
0.0052253566682338715,
-0.01599028892815113,
-0.006476416252553463,
0.03577449172735214,
0.0028425243217498064,
-0.026627207174897194,
0.005341734271496534,
-0.039777882397174835,
0.033353835344314575,
0.007942775264382362,
-0.025928940623998642,
-0.006918651517480612,
0.02095961570739746,
-0.019307052716612816,
0.00944986566901207,
-0.016071753576397896,
0.01859714835882187,
-0.01791052147746086,
0.003267302643507719,
-0.016909673810005188,
0.04352524131536484,
-0.007395799737423658,
-0.01725880615413189,
-0.002205356489866972,
-0.023322081193327904,
-0.01941179297864437,
0.015815723687410355,
-0.013197226449847221,
0.027441851794719696,
0.036309827119112015,
0.03789256513118744,
-0.022868208587169647,
0.040127016603946686,
-0.011178073473274708,
-0.033819347620010376,
-0.042780425399541855,
-0.02375268004834652,
0.03156162053346634,
0.0014678131556138396,
-0.031119385734200478,
0.048785511404275894,
0.046364858746528625,
0.003075279528275132,
0.008606127463281155,
0.027465127408504486,
0.024765165522694588,
0.02035445161163807,
-0.001715115737169981,
-0.03244609013199806,
0.0024162910412997007,
0.004372890572994947,
0.023880694061517715,
-0.029513373970985413,
-0.08532809466123581,
0.03482019528746605,
-0.0015245472313836217,
-0.030421119183301926,
-0.0011703227646648884,
-0.017642851918935776,
-0.009903738275170326,
0.04827345162630081,
-0.03537880629301071,
0.04077873006463051,
0.06503183394670486,
-0.008355915546417236,
-0.015396763570606709,
-0.05344061926007271,
-0.005920713301748037,
-0.027884086593985558,
0.018352756276726723,
-0.049483779817819595,
0.0011943256249651313,
0.06926798075437546,
0.021797534078359604,
0.009025086648762226,
-0.007936956360936165,
-0.00488204276189208,
0.040057189762592316,
0.017200617119669914,
0.0011281358310952783,
-0.03216678276658058,
-0.026184972375631332,
0.02520740032196045,
-0.0006317124352790415,
0.03763653337955475,
-0.014814875088632107,
-0.04366489499807358,
0.014814875088632107,
-0.019900579005479813,
0.026603931561112404,
-0.01857387274503708,
-0.008041695691645145,
0.020110059529542923,
0.012219653464853764,
-0.02372940443456173,
-0.018818266689777374,
0.0635422021150589,
0.002183535834774375,
-0.042943354696035385,
-0.0065055107697844505,
0.04794759303331375,
0.027744432911276817,
0.024229828268289566,
-0.0035058767534792423,
0.04541056230664253,
-0.07471445202827454,
0.030351292341947556,
0.02220485731959343,
-0.029047861695289612,
0.006319306790828705,
0.013965318910777569,
-0.014861426316201687,
0.027278922498226166,
-0.040010638535022736,
-0.039335645735263824,
-0.021529866382479668,
-0.020098421722650528,
0.007634374313056469,
-0.02527722716331482,
-0.05614057928323746,
0.02255398966372013,
0.03419175371527672,
-0.07629719376564026,
-0.005885799881070852,
0.015175646170973778,
0.002145712962374091,
0.01714242808520794,
-0.021506590768694878,
-0.021750982850790024,
-0.0012176012387499213,
0.055302660912275314,
0.016583815217018127,
-0.0027712429873645306,
-0.04664416238665581,
-0.01714242808520794,
-0.015210559591650963,
-0.039894260466098785,
-0.027325473725795746,
-0.003913198597729206,
-0.019970405846834183,
0.045899346470832825,
-0.019516533240675926,
-0.014675222337245941,
0.0046260119415819645,
0.009985202923417091,
0.007151406724005938,
0.012149827554821968,
0.03826497122645378,
0.006040000356733799,
-0.00522826611995697,
0.005557033233344555,
-0.01631614752113819,
-0.021320385858416557,
0.026906514540314674,
-0.0044863587245345116,
0.029466822743415833,
-0.013371792621910572,
0.006179653573781252,
-0.010002659633755684,
0.01578081026673317,
0.013511445373296738,
0.005626859609037638,
0.01573425903916359,
-0.042524393647909164,
0.013197226449847221,
-0.01952817104756832,
0.03761325776576996,
-0.052835457026958466,
0.015326936729252338,
0.05423198640346527,
0.02576601319015026,
0.06368185579776764,
0.04475884512066841,
0.01409333385527134,
0.026441002264618874,
-0.014617033302783966,
-0.0006804455770179629,
0.0065055107697844505,
0.01429117564111948,
-0.019807476550340652,
-0.015885550528764725,
0.0066335261799395084,
0.01770104095339775,
-0.022775106132030487,
-0.029885781928896904,
0.00640658987686038,
-0.009397495537996292,
-0.012917920015752316,
0.03449433669447899,
-0.01791052147746086,
-0.01887645572423935,
-0.04447953775525093,
-0.000007108810677891597,
-0.02886165864765644,
-0.07583168148994446,
-0.005298092495650053,
-0.019679460674524307,
-0.010229595936834812,
0.033121079206466675,
-0.04091838374733925,
-0.02255398966372013,
0.0024002890568226576,
0.026580655947327614,
-0.027022890746593475,
-0.013499807566404343,
-0.006924470420926809,
0.03512277454137802,
0.03502967581152916,
0.018329480662941933,
0.0027523315511643887,
0.01028196606785059,
-0.02075013518333435,
-0.023694491013884544,
0.0281401164829731,
0.00239447015337646,
0.052416495978832245,
-0.0325857438147068,
0.015094181522727013,
-0.02075013518333435,
-0.012080000713467598,
0.006650982890278101,
-0.027860810980200768,
-0.012312755919992924,
0.0048354915343225,
-0.005510482005774975,
-0.023903969675302505,
-0.01626959629356861,
0.02098289132118225,
-0.021576417610049248,
-0.00628439337015152,
0.0010132129536941648,
0.011375916190445423,
0.0002720327756833285,
-0.010671830736100674,
-0.004250694066286087,
-0.02260054089128971,
0.006086551118642092,
0.02185572311282158,
-0.023903969675302505,
0.022810019552707672,
0.04864586144685745,
-0.01599028892815113,
-0.0022824567276984453,
-0.006063275970518589,
0.0030170907266438007,
-0.015222197398543358,
-0.05371992662549019,
0.008972717449069023,
0.024718614295125008,
-0.039475299417972565,
-0.0035291523672640324,
-0.03819514438509941,
-0.008344277739524841,
-0.007087399251759052,
0.030909905210137367,
0.05120616778731346,
0.036100346595048904,
0.02250743843615055,
0.013942043296992779,
-0.018655337393283844,
0.007355067878961563,
0.006243661046028137,
-0.005362100433558226,
-0.01929541490972042,
0.004390346817672253,
-0.001488179201260209,
-0.008233719505369663,
-0.007157225627452135,
-0.006371676456183195,
-0.021378574892878532,
0.010229595936834812,
-0.0226238165050745,
-0.026557380333542824,
0.012254566885530949,
-0.029769403859972954,
0.02026134915649891,
0.005140983033925295,
-0.04804069548845291,
0.046551063656806946,
0.009141464717686176,
0.013499807566404343,
0.03565811365842819,
-0.006086551118642092,
0.024416031315922737,
-0.019819114357233047,
-0.02557980827987194,
0.006138921249657869,
0.01770104095339775,
-0.006470597814768553,
-0.0064822351559996605,
-0.033237457275390625,
-0.016956225037574768,
-0.01608339138329029,
0.02858235128223896,
-0.010084123350679874,
0.015350212343037128,
-0.024066898971796036,
-0.011940347030758858,
0.043036457151174545,
-0.01568770781159401,
-0.00819298718124628,
0.06033017486333847,
-0.026394452899694443,
0.016071753576397896,
0.003508786205202341,
0.014326089061796665,
0.011515568941831589,
0.009641888551414013,
-0.0008735597948543727,
0.024439306929707527,
-0.02220485731959343,
-0.017596300691366196,
-0.005001329816877842,
0.030165087431669235,
-0.023438459262251854,
-0.03132886439561844,
-0.023089326918125153,
0.03598397225141525,
0.00110486033372581,
0.02506774663925171,
-0.0008633767138235271,
0.016257958486676216,
-0.013651099056005478,
0.03479691967368126,
0.029629750177264214,
-0.015222197398543358,
-0.0016031021950766444,
0.005135164130479097,
0.003776454832404852,
0.026953063905239105,
0.018224740400910378,
0.0005877071525901556,
0.0025152121670544147,
-0.02541687898337841,
0.021448401734232903,
0.04112786427140236,
0.022565627470612526,
0.026766860857605934,
-0.016828209161758423,
-0.033772796392440796,
-0.009682620875537395,
-0.008350096642971039,
-0.04070890322327614,
0.007867129519581795,
-0.0002345737157156691,
0.016560539603233337,
0.01952817104756832,
-0.029490098357200623,
0.002361011691391468,
0.03812532126903534,
-0.001960963476449251,
0.00037750002229586244,
0.020098421722650528,
0.0002207538636866957,
-0.014791599474847317,
0.014372640289366245,
-0.003840462537482381,
-0.024485858157277107,
0.0017776687163859606,
0.008134798146784306,
0.030444394797086716,
0.001760212006047368,
0.009438227862119675,
-0.015489866025745869,
-0.03719429671764374,
0.03277194872498512,
0.037008095532655716,
0.02100616693496704,
-0.04357179254293442,
0.024020347744226456,
0.005257360637187958,
-0.03114265948534012,
-0.013069210574030876,
0.03219005838036537,
0.010415799915790558,
0.0016249229665845633,
-0.004986782558262348,
-0.01587391272187233,
-0.024276379495859146,
-0.013162313029170036,
-0.026906514540314674,
-0.008961079642176628,
0.0066917152144014835,
0.02058720774948597,
0.004774393048137426,
-0.012464046478271484,
-0.0008888343581929803,
-0.027674606069922447,
0.0010823121992871165,
0.0011390462750568986,
0.03554173558950424,
-0.027185820043087006,
0.06042327731847763,
-0.05348717048764229,
-0.008897071704268456,
-0.010712563060224056,
-0.03225988522171974,
-0.003191657131537795,
-0.005138073582202196,
-0.0046812910586595535,
0.02823321893811226,
-0.027674606069922447,
-0.04799414426088333,
0.0066684396006166935,
0.005385376047343016,
-0.0007579094963148236,
-0.027465127408504486,
-0.021529866382479668,
0.024741889908909798,
-0.02862890250980854,
0.031026283279061317,
0.04052269831299782,
0.008611946366727352,
0.019679460674524307,
-0.043083008378744125,
-0.024183277040719986,
0.007686743978410959,
-0.04780793935060501,
-0.049204472452402115,
-0.0027261464856565,
-0.010427437722682953,
-0.002289730357006192,
-0.0002883983834180981,
-0.00928693637251854,
-0.03849772736430168,
-0.00895526073873043,
0.04457264021039009,
0.003404046408832073,
0.01016558799892664,
-0.015257110819220543,
-0.006028362549841404,
-0.0029632661025971174,
0.021110907196998596,
-0.016804933547973633,
0.01615321822464466,
-0.032120231539011,
0.018166551366448402,
-0.0019813296385109425,
-0.006749903783202171,
-0.0013077938929200172,
-0.00711649376899004,
0.011975260451436043,
0.004684200510382652,
-0.022123392671346664,
0.01559460535645485,
-0.027721157297492027,
-0.005658863577991724,
-0.06712663173675537,
-0.011259538121521473,
-0.03207368031144142,
-0.0074656265787780285,
0.005964354611933231,
-0.0026766860391944647,
-0.015187283977866173,
-0.017410097643733025,
-0.0063309445977211,
0.021285472437739372,
-0.030840078368782997,
0.030118536204099655,
-0.04163992404937744,
-0.022833295166492462,
0.016851484775543213,
-0.06987314671278,
0.00011528661707416177,
0.027139268815517426,
-0.010602003894746304,
0.016444163396954536,
0.0071397689171135426,
-0.020086783915758133,
0.0178174190223217,
0.03824169561266899,
-0.03554173558950424,
0.0031043740455061197,
-0.01784069463610649,
0.024485858157277107,
0.0102586904540658,
0.006040000356733799,
-0.016607090830802917,
-0.02883838303387165,
-0.06559044867753983,
0.01400023140013218,
0.010869672521948814,
-0.009833911433815956,
0.02511429786682129,
-0.0014685405185446143,
0.00886215828359127,
-0.00515262084081769,
0.014593757688999176,
0.0037910020910203457,
-0.004009210038930178,
-0.030490946024656296,
-0.006109826732426882,
-0.009019268676638603,
0.023252256214618683,
-0.0018693160964176059,
0.004716204479336739,
-0.01894628256559372,
-0.045852795243263245,
0.020272986963391304,
-0.01117225456982851,
0.01285973098129034,
-0.019237225875258446,
-0.00283379596658051,
0.0117832375690341,
0.03919599577784538,
0.0038899232167750597,
-0.061354298144578934,
-0.0019347785273566842,
-0.03605379909276962,
0.018492409959435463,
0.007704200688749552,
-0.01016558799892664,
0.03835807368159294,
-0.03523915261030197,
-0.029909057542681694,
0.009781542234122753,
-0.023997072130441666,
-0.01575753465294838,
0.007931137457489967,
0.07229379564523697,
0.012359307147562504,
0.02502119541168213,
-0.00471329502761364,
0.02853580005466938,
0.03130558878183365,
-0.008920347318053246,
-0.008233719505369663,
-0.0105496346950531,
-0.005335915368050337,
0.00429724482819438,
-0.01169013511389494,
0.017642851918935776,
0.004247784614562988,
0.06023707240819931,
-0.051950983703136444,
0.04140716791152954,
-0.01114897895604372,
-0.016257958486676216,
0.018387669697403908,
0.00714558782055974,
0.017247168347239494,
-0.005353372078388929,
-0.02844269946217537,
-0.00016092848090920597,
-0.007523815147578716,
-0.0005622495664283633,
-0.029559923335909843,
0.014779961667954922,
-0.013674374669790268,
0.011672678403556347,
-0.00022620907111559063,
-0.008373372256755829,
0.013406706042587757,
0.0026868691202253103,
0.004634740296751261,
0.007872948423027992,
0.03223660960793495,
-0.02588239125907421,
-0.014279537834227085,
-0.01021213922649622,
0.006761541590094566,
-0.009170559234917164,
0.01737518422305584,
-0.01585063710808754,
-0.024253103882074356,
-0.03475036844611168,
-0.024066898971796036,
-0.004303063731640577,
0.013918767683207989,
-0.01751483790576458,
0.0060690948739647865,
-0.002617042511701584,
0.049530331045389175,
0.020028594881296158,
0.005612312350422144,
-0.022169943898916245,
-0.0014874519547447562,
-0.02037772722542286,
0.03265557065606117,
-0.03735722601413727,
0.024113450199365616,
0.018632061779499054,
0.05446474254131317,
0.007669287268072367,
-0.027441851794719696,
-0.023880694061517715,
0.012138189747929573,
-0.007401618640869856,
0.01578081026673317,
0.017468286678195,
0.007197957951575518,
-0.02361302636563778,
0.02246088720858097,
-0.005222447216510773,
0.033051252365112305,
0.009560423903167248,
-0.02331044338643551,
0.021809171885252,
-0.0030112718231976032,
0.0410347618162632,
-0.029140964150428772,
0.021797534078359604,
-0.00621456652879715,
-0.019563084468245506,
-0.0035902506206184626,
-0.024299655109643936,
0.019516533240675926,
-0.017479924485087395,
-0.040150292217731476,
0.02511429786682129,
-0.039777882397174835,
-0.01559460535645485,
0.007308516651391983,
0.01924886368215084,
0.019353603944182396,
0.039940811693668365,
0.009729172103106976,
0.02867545373737812,
0.03526242822408676,
0.026697034016251564,
-0.052276842296123505,
0.00947314128279686,
-0.009769904427230358,
0.033353835344314575,
-0.02338027022778988,
-0.014349364675581455,
-0.012242929078638554,
-0.005472659133374691,
-0.012533873319625854,
0.011556301265954971,
0.015396763570606709,
-0.0050507900305092335,
-0.012045087292790413,
-0.0635422021150589,
0.04494505003094673,
-0.03495984897017479,
-0.036356378346681595,
0.03251591697335243,
0.07350412756204605,
0.001684566494077444,
0.015105819329619408,
0.03181765228509903,
-0.011294451542198658,
0.01802689954638481,
0.0052369944751262665,
0.040243394672870636,
0.014104971662163734,
-0.010596184991300106,
-0.027162544429302216,
-0.027558228000998497,
0.024672063067555428,
0.012161465361714363,
-0.019539808854460716,
-0.0042652408592402935,
0.031003007665276527,
0.052183739840984344,
-0.0017282081535086036,
-0.011626128107309341,
-0.030421119183301926,
-0.002926897956058383,
-0.01254551112651825,
-0.014779961667954922,
-0.05916639789938927,
0.015292024239897728,
0.030560772866010666,
-0.008233719505369663,
0.0037299038376659155,
0.032981425523757935,
0.011963622644543648,
-0.03256246820092201,
-0.009461503475904465,
0.020435916259884834,
0.021809171885252,
0.05115961655974388,
-0.023077689111232758,
0.058747440576553345,
-0.004116859752684832,
-0.012045087292790413,
0.00016574723122175783,
0.008926166221499443,
-0.036100346595048904,
-0.020505743101239204,
-0.048738960176706314,
-0.009746628813445568,
-0.007669287268072367,
0.0003764089778997004,
-0.013604547828435898,
0.030165087431669235,
-0.010607822798192501,
0.018538961187005043,
-0.012033449485898018,
0.027977189049124718,
0.020063508301973343,
0.002500664908438921,
0.03535553067922592,
-0.007040848024189472,
0.03279522433876991,
-0.0006313487538136542,
0.0027334201149642467,
-0.008565395139157772,
-0.005210809409618378,
0.020121697336435318,
0.04052269831299782,
0.02883838303387165,
-0.0159437395632267,
-0.030374567955732346,
-0.015233835205435753,
-0.010322698391973972,
0.04231491684913635,
-0.0014438102953135967,
0.013464895077049732,
-0.058607786893844604,
-0.04482867196202278,
0.0030490944627672434,
0.004154682159423828,
-0.013732563704252243,
0.0475984625518322,
0.006255298852920532,
0.004797668661922216,
0.0013819846790283918,
-0.0006906286580488086,
-0.023170791566371918,
0.006354219745844603,
-0.025952216237783432,
0.02255398966372013,
0.01894628256559372,
0.017689403146505356,
-0.0034011369571089745,
0.02183244749903679,
0.014395915903151035,
0.04717950150370598,
0.0005607948405668139,
0.005586127284914255,
0.012277842499315739,
0.017060963436961174,
-0.0020715221762657166,
0.002976358402520418,
0.004381618462502956,
0.015117457136511803,
0.002714508678764105,
-0.026487553492188454,
-0.007285241037607193,
-0.02264709211885929,
0.007378343492746353,
-0.021494952961802483,
0.027092717587947845,
-0.0014510839246213436,
0.008600308559834957,
0.00700011570006609,
-0.017200617119669914,
-0.014058420434594154,
0.008175530470907688,
-0.016001926735043526,
0.009065818972885609,
-0.0513458214700222,
-0.023880694061517715,
-0.009222929365932941,
-0.0024570231325924397,
0.01281317975372076,
-0.0006640799692831933,
-0.00355824688449502,
0.009636069647967815,
0.019190674647688866,
0.052509598433971405,
0.0007291787187568843,
-0.004608555231243372,
0.027278922498226166,
-0.016397612169384956,
-0.033051252365112305,
-0.039870984852313995,
0.048878613859415054,
-0.00031858382862992585,
-0.039847709238529205,
0.027139268815517426,
0.01647907681763172,
-0.026953063905239105,
0.007710019592195749,
-0.011364278383553028,
-0.03426158055663109,
0.009915376082062721,
0.012033449485898018,
0.021204007789492607,
-0.014838150702416897,
0.0032585742883384228,
0.005306820850819349,
0.010014297440648079,
-0.03526242822408676,
0.004992601461708546,
-0.005879980977624655,
-0.007052485831081867,
-0.010055029764771461,
-0.019539808854460716,
0.04480539634823799,
0.005766512826085091,
-0.001152138807810843,
-0.018701888620853424,
0.02065703459084034,
0.02578928880393505,
-0.005635587964206934,
-0.023857418447732925,
-0.0027886994648724794,
0.027534952387213707,
-0.030560772866010666,
0.003206204390153289,
-0.005801426246762276,
0.029350444674491882,
0.007890405133366585,
-0.010084123350679874,
-0.005693776533007622,
-0.0018387669697403908,
-0.049064818769693375,
-0.0018765897257253528,
0.055581968277692795,
0.007430713158100843,
-0.03402882441878319,
0.031026283279061317,
0.018201464787125587,
0.010159769095480442,
0.005318458657711744,
-0.0035902506206184626,
0.0075005399994552135,
-0.06093534082174301,
-0.026790136471390724,
0.024346204474568367,
0.04382782429456711,
0.0038957418873906136,
-0.002059884602203965,
0.023880694061517715,
-0.033027976751327515,
-0.04070890322327614,
-0.0031800193246454,
-0.00883888266980648,
0.0013899855548515916,
0.010514721274375916,
-0.04145371913909912,
0.016490712761878967,
-0.0060458192601799965,
0.008251175284385681,
0.05120616778731346,
0.016723468899726868,
-0.0049955109134316444,
-0.007756570819765329,
-0.023007862269878387,
0.013592910021543503,
0.031119385734200478,
-0.004052851814776659,
-0.008850520476698875,
-0.005507572554051876,
-0.024695338681340218,
-0.030397843569517136,
0.00448926817625761,
-0.018399307504296303,
-0.0172355305403471,
0.004099403042346239,
0.04098821058869362,
0.011079153046011925,
-0.021576417610049248,
-0.006825549528002739,
-0.010764933191239834,
-0.009036724455654621,
-0.017479924485087395,
-0.010642736218869686,
-0.05371992662549019,
0.0175846628844738,
0.03174782544374466,
-0.02530050277709961,
0.026510829105973244,
0.0048209442757070065,
-0.018422583118081093,
0.004786030855029821,
0.011533025652170181,
0.018701888620853424,
-0.02876855619251728,
0.03579776734113693,
-0.05330096557736397,
0.002893439494073391,
-0.01735190860927105,
0.010357610881328583,
-0.004916955716907978,
0.0048354915343225,
-0.016653642058372498,
0.013511445373296738,
0.01896955817937851,
-0.01254551112651825,
0.0023362813517451286,
0.006464778911322355,
-0.013243776746094227,
-0.0016569268191233277,
0.01032851729542017,
0.006546243093907833,
-0.03561156243085861,
0.013011021539568901,
-0.002281002001836896,
-0.02550998143851757,
0.01589718833565712,
-0.007471445482224226,
-0.03770636022090912,
0.03265557065606117,
0.0172355305403471,
0.016490712761878967,
-0.005772331729531288,
0.02848925068974495,
0.013534720987081528,
0.003366223769262433,
0.024834992364048958,
0.026953063905239105,
-0.004780211951583624,
-0.026347901672124863,
-0.03216678276658058,
-0.007506358902901411,
0.0040586707182228565,
0.023857418447732925,
0.014745049178600311,
0.02225140668451786,
-0.018841542303562164,
-0.016758382320404053,
-0.03284177556633949,
0.018282929435372353,
-0.033237457275390625,
0.0015274566831067204,
0.011579576879739761,
0.011393371969461441,
-0.033516764640808105,
0.004262331407517195,
-0.0031131021678447723,
0.026301350444555283,
-0.0044747209176421165,
-0.0022082659415900707,
-0.01619976945221424,
0.007605279795825481,
0.0040819463320076466,
-0.030677149072289467,
0.010107398964464664,
0.008460655808448792,
-0.0009048362844623625,
0.023415183648467064,
-0.012266204692423344,
-0.05292855575680733,
0.05693195015192032,
-0.006552061997354031,
0.010689287446439266,
-0.033749520778656006,
-0.0012605154188349843,
0.016257958486676216,
-0.0031683817505836487,
0.0018780444515869021,
0.013942043296992779,
0.001459812163375318,
0.0054901158437132835,
-0.050182044506073,
0.052369944751262665,
-0.010799846611917019,
-0.006342582404613495,
-0.026627207174897194,
0.0035146051086485386,
-0.00809988472610712,
0.004594007972627878,
0.005245722830295563,
0.015722621232271194,
-0.011096609756350517,
-0.0034244125708937645,
-0.03866065666079521,
-0.0024555684067308903,
0.004919865168631077,
0.007471445482224226,
-0.010863853618502617,
0.012312755919992924,
0.01887645572423935,
-0.02075013518333435,
-0.09310212731361389,
-0.011032601818442345,
0.005120616871863604,
-0.005813064053654671,
0.0009753901977092028,
-0.0002951264614239335,
0.014326089061796665,
0.029117688536643982,
-0.015082543715834618,
-0.020156608894467354,
0.010159769095480442,
-0.007692562881857157,
0.004547456745058298,
0.010543815791606903,
0.010183044709265232,
0.012510597705841064,
-0.018271291628479958,
0.0172355305403471,
-0.036286551505327225,
0.0034156842157244682,
0.04110458865761757,
-0.02026134915649891,
0.006168015766888857,
0.05106651410460472,
0.014756686985492706,
0.01716570369899273,
-0.013569634407758713,
-0.027534952387213707,
0.003930655308067799,
-0.03861410543322563,
-0.009444046765565872,
-0.013418343849480152,
-0.010194682516157627,
0.011597033590078354,
-0.01104423962533474,
-0.0019231407204642892,
-0.013104123994708061,
0.006325125694274902,
-0.005766512826085091,
-0.009688439778983593,
-0.01622304506599903,
0.004177957773208618,
0.0056763202883303165,
0.0025239402893930674,
0.0009906648192554712,
0.007448169868439436,
0.01612994261085987,
-0.023345356807112694,
-0.012277842499315739,
-0.004140134900808334,
-0.013185588642954826,
-0.011655221693217754,
0.015932101756334305,
0.004818034823983908,
-0.042873527854681015,
0.03554173558950424,
0.013569634407758713,
0.009234567172825336,
-0.016048477962613106,
-0.022961311042308807,
-0.01589718833565712,
-0.006784817203879356,
-0.021704433485865593,
-0.002065703272819519,
0.019679460674524307,
-0.016490712761878967,
0.015280386433005333,
-0.014919615350663662,
0.016444163396954536,
0.00962443184107542,
0.020459191873669624,
0.010439075529575348,
-0.019923854619264603,
-0.013162313029170036,
0.03191075474023819,
0.010625279508531094,
0.0018402216956019402,
-0.04159337282180786,
-0.0033982275053858757,
-0.0035262429155409336,
-0.03435468301177025,
0.00311892107129097,
0.010782389901578426,
-0.05977156385779381,
0.012708439491689205,
-0.006971021648496389,
0.002254817169159651,
0.005635587964206934,
0.04459591582417488,
0.0032993066124618053,
0.008833063766360283,
-0.007907861843705177,
-0.008012601174414158,
0.052090637385845184,
0.03414520248770714,
-0.024462582543492317,
-0.018189826980233192,
0.015082543715834618,
-0.01633942313492298,
-0.007273603230714798,
-0.024834992364048958,
-0.05986466631293297,
0.017247168347239494,
-0.005391194950789213,
-0.004477630369365215,
0.016979500651359558,
-0.013301965780556202,
-0.009560423903167248,
0.03521587699651718,
-0.007058304734528065,
0.028372872620821,
0.008297726511955261,
0.00821626279503107,
0.023298805579543114,
0.033935725688934326,
-0.03144524246454239,
0.013499807566404343,
0.023019500076770782,
0.029955608770251274,
-0.00044368981616571546,
0.0036891717463731766,
0.045620039105415344,
-0.029769403859972954,
-0.033190906047821045,
0.0160601157695055,
0.020529018715023994,
-0.026673758402466774,
0.014011869207024574,
0.0028541618958115578,
-0.03786928951740265,
0.020110059529542923,
-0.017852332442998886,
0.024322930723428726,
-0.007931137457489967,
0.01038670539855957,
-0.0022344510070979595,
0.03186420351266861,
-0.027744432911276817,
-0.007343430072069168,
-0.031119385734200478,
-0.014931253157556057,
-0.0040586707182228565,
-0.007989325560629368,
-0.0023130059707909822,
0.017293719574809074,
0.01709587685763836,
0.01718897931277752,
0.02178589627146721,
0.03416847810149193,
-0.00518171489238739,
0.007547090761363506,
-0.033051252365112305,
0.023217342793941498,
0.02511429786682129,
-0.02504447102546692,
0.03568138927221298,
0.001646743854507804,
-0.0031480155885219574,
0.02260054089128971,
0.033889174461364746,
0.011183892376720905,
-0.02171606943011284,
-0.006662620697170496,
-0.016595453023910522,
0.011143160052597523,
-0.03512277454137802,
-0.010497264564037323,
0.09701241552829742,
-0.04473556950688362,
-0.024043623358011246,
-0.023054413497447968,
0.024672063067555428,
-0.012603700160980225,
0.008990174159407616,
0.0037066282238811255,
0.020459191873669624,
0.0046696532517671585,
0.018143275752663612,
-0.016816571354866028,
0.004623102489858866,
0.011230443604290485,
0.013755838386714458,
0.0007149951998144388,
0.03239953890442848,
0.005911984946578741,
0.008175530470907688,
-0.002157350769266486,
-0.006028362549841404,
0.04038304463028908,
-0.026278074830770493,
0.04184940457344055,
0.01283645536750555,
0.004797668661922216,
-0.022798381745815277,
-0.010991869494318962,
0.021448401734232903,
-0.023217342793941498,
0.014966166578233242,
-0.002922533778473735,
0.012359307147562504,
0.015501503832638264,
0.01770104095339775,
-0.021622968837618828,
0.017945434898138046,
-0.006150559056550264,
0.0347038172185421,
-0.0005076975212432444,
-0.013872216455638409,
0.03174782544374466,
0.005027514882385731,
0.03170127421617508,
0.011742505244910717,
0.04457264021039009,
-0.024136725813150406,
-0.019854027777910233,
-0.005920713301748037,
-0.013988594524562359,
0.02553325705230236,
-0.015338574536144733,
0.0027552410028874874,
-0.0039277458563447,
-0.01728208176791668,
-0.01131190825253725,
-0.011509750038385391,
-0.029210790991783142,
-0.014512293972074986,
-0.03884686157107353,
0.0008662861655466259,
-0.00008714685827726498,
-0.007552909664809704,
0.0038550097960978746,
-0.007843853905797005
] | 2024-07-17 | 21 | 39018097 | [
"development integrate gene therapy",
"classical gene therapy vectors",
"endogenous genes",
"chimeric antigen receptor transgenes",
"human cells",
"therapeutic intervention",
"novel biological functions",
"Chimeric antigen receptor-engineered T lymphocytes",
"therapeutic efficacy",
"gene-edited cell products",
"CRISPR)-based technologies",
"genome editing",
"clustered regularly interspaced short palindromic repeats",
"precision medicine",
"T-cell genomes",
"insertions",
"complexity",
"Methods",
"these therapies",
"a new era",
"the current state",
"scientific, translational, and regulatory oversight",
"The broad use",
"a remarkable pace",
"the door",
"the way",
"the genomes",
"we"
] | [] | 0 | 10.1158/2326-6066.CIR-24-0482
10.1158/2326-6066.CIR-24-0251
10.1038/s41588-022-01257-y
10.1038/s41467-021-25190-6
10.1038/s41588-021-00838-7
10.1038/nbt.4192
10.1016/j.cell.2023.08.041
10.1089/crispr.2021.0113
10.1038/nbt.3117
10.1186/s13059-019-1625-3
10.1038/s41467-022-28135-9
10.1126/science.aav9023
10.1038/s41587-020-0555-7
10.1038/nmeth.4278
10.1038/nmeth.4284
10.1038/s41598-021-03160-8
10.1038/s41591-023-02767-w
10.1182/blood.2020010497
10.1038/mt.2016.38
10.1038/nature21405
10.1126/science.aba7365 | [
"Jadlowsky",
"Chang",
"Spencer",
"Warrington",
"Levine",
"June",
"Fraietta",
"Singh"
] | [
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania.",
"Center for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.\nDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Washington University School of Medicine, St. Louis, Missouri.",
"Center for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.\nDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania.\nDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania.\nDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.",
"Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania.\nDepartment of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania.",
"Center for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.\nDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri."
] | [
"39018097",
"38869428",
"36522432",
"34389729",
"33846636",
"30010673",
"37794590",
"35119294",
"25513782",
"30654827",
"35064134",
"31000663",
"32541958",
"28459458",
"28459459",
"34880355",
"38195751",
"33822002",
"26867951",
"28225754",
"32029687"
] | [] | 9.299835 | 2.904471 |
39017904 | 718 | Immunotherapy in the Context of Aortic Valve Diseases. | Aortic valve disease (AVD) affects millions of people around the world, with no pharmacological intervention available. Widely considered a multi-faceted disease comprising both regurgitative pathogenesis, in which retrograde blood flows back through to the left ventricle, and aortic valve stenosis, which is characterized by the thickening, fibrosis, and subsequent mineralization of the aortic valve leaflets, limiting the anterograde flow through the valve, surgical intervention is still the main treatment, which incurs considerable risk to the patient.
Though originally thought of as a passive degeneration of the valve or a congenital malformation that has occurred before birth, the paradigm of AVD is shifting, and research into the inflammatory drivers of valve disease as a potential mechanism to modulate the pathobiology of this life-limiting pathology is taking center stage. Following limited success in mainstay therapeutics such as statins and mineralisation inhibitors, immunomodulatory strategies are being developed. Immune cell therapy has begun to be adopted in the cancer field, in which T cells (chimeric antigen receptor (CAR) T cells) are isolated from the patient, programmed to attack the cancer, and then re-administered to the patient. Within cardiac research, a novel T cell-based therapeutic approach has been developed to target lipid nanoparticles responsible for increasing cardiac fibrosis in a failing heart. With clonally expanded T-cell populations recently identified within the diseased valve, their unique epitope presentation may serve to identify novel targets for the treatment of valve disease.
Taken together, targeted T-cell therapy may hold promise as a therapeutic platform to target a multitude of diseases with an autoimmune aspect, and this review aims to frame this in the context of cardiovascular disease, delineating what is currently known in the field, both clinically and translationally. | [
-0.012563270516693592,
0.014740904793143272,
0.04393555223941803,
0.06915781646966934,
-0.009404505603015423,
0.03137228265404701,
-0.007083291653543711,
-0.004421074874699116,
0.0006090942770242691,
0.002360100159421563,
-0.00034362042788416147,
-0.014178548939526081,
-0.04271512106060982,
0.007986650802195072,
-0.013520472683012486,
-0.03819234296679497,
0.06700411438941956,
0.005599629133939743,
0.04702252894639969,
0.02403772436082363,
0.02287711761891842,
0.00529452133923769,
0.016009196639060974,
0.004262538161128759,
0.015853650867938995,
-0.038455575704574585,
0.005817990750074387,
0.0024498377460986376,
0.013795668259263039,
-0.06614263355731964,
0.05082740634679794,
-0.026801643893122673,
0.009631841443479061,
0.043289441615343094,
-0.020735379308462143,
0.05618773400783539,
0.03809662163257599,
-0.023965934291481972,
-0.00452576857060194,
0.013376892544329166,
0.04242796078324318,
-0.006538883317261934,
-0.0025620099622756243,
0.06441966444253922,
-0.04838654026389122,
0.007609752472490072,
-0.014561429619789124,
-0.019969617947936058,
-0.03972386568784714,
-0.005132993683218956,
-0.017576614394783974,
0.009039572440087795,
-0.02574872225522995,
0.046400345861911774,
-0.017516789957880974,
0.041470758616924286,
-0.026921294629573822,
-0.008895992301404476,
-0.007376434747129679,
0.016942467540502548,
0.006712376140058041,
0.005156923551112413,
0.010212144814431667,
-0.018509885296225548,
-0.027998145669698715,
-0.03441139683127403,
-0.013197417370975018,
0.014693044126033783,
0.012018862180411816,
-0.01349654234945774,
0.01821075938642025,
-0.038383785635232925,
0.010104459710419178,
0.045945677906274796,
-0.026705924421548843,
-0.032377343624830246,
-0.04111180827021599,
0.023068558424711227,
0.0010940515203401446,
0.03615828976035118,
0.03663689270615578,
-0.008644727058708668,
-0.025246191769838333,
0.015841687098145485,
-0.01824665442109108,
-0.003945465199649334,
0.013005976565182209,
-0.013388857245445251,
0.0002864126581698656,
-0.018641501665115356,
0.015087890438735485,
0.01981407217681408,
-0.0570492148399353,
0.014070863835513592,
0.005964562296867371,
0.05111456662416458,
0.004941553343087435,
-0.01956280693411827,
-0.010774500668048859,
0.004720200318843126,
-0.019072242081165314,
0.007896913215517998,
0.013831563293933868,
-0.011863317340612411,
0.022290831431746483,
-0.0366608202457428,
0.0028237446676939726,
-0.00035969840246252716,
0.01964656263589859,
0.008997694589197636,
0.04537135362625122,
-0.017421068623661995,
-0.05791069567203522,
0.041829708963632584,
-0.018485955893993378,
-0.058102138340473175,
-0.0733216404914856,
0.04132717847824097,
0.012922221794724464,
-0.000025893050406011753,
-0.0179116353392601,
0.053555428981781006,
-0.003389091929420829,
0.029266439378261566,
0.009524155408143997,
-0.04355267062783241,
0.01975424773991108,
-0.023726634681224823,
-0.06451538950204849,
-0.07691115140914917,
0.06480254977941513,
-0.009428435936570168,
0.03323882445693016,
-0.007753333076834679,
-0.056666333228349686,
-0.00046738359378650784,
-0.014238373376429081,
0.06035156175494194,
-0.009936949238181114,
-0.03515322878956795,
0.005192818585783243,
-0.011635981500148773,
0.02895534783601761,
-0.008040493354201317,
-0.0008450295426882803,
-0.006556830834597349,
0.0302715003490448,
0.03043900988996029,
-0.03958028554916382,
0.029768969863653183,
-0.03199446201324463,
0.08097925782203674,
0.07576250284910202,
-0.0016496771713718772,
-0.004492864944040775,
-0.03048687055706978,
-0.008483199402689934,
0.07016287744045258,
-0.0049116406589746475,
-0.03220983222126961,
-0.036947980523109436,
-0.00828577671200037,
0.02565300278365612,
-0.04405520483851433,
0.01836630515754223,
0.004101010505110025,
-0.03534466773271561,
0.003822823753580451,
-0.010379654355347157,
-0.020819135010242462,
-0.020795203745365143,
-0.06183522194623947,
-0.07250802218914032,
-0.0036732610315084457,
-0.02589230239391327,
-0.042930491268634796,
-0.0035835234448313713,
-0.0053693028166890144,
-0.019179927185177803,
-0.02701701410114765,
-0.0010940515203401446,
0.06231382489204407,
-0.010720658116042614,
-0.011689824052155018,
-0.006873903796076775,
0.011462489143013954,
-0.052167486399412155,
0.025006892159581184,
-0.04345695301890373,
-0.022147251293063164,
-0.01054716482758522,
0.0032215816900134087,
0.06217024475336075,
-0.005575699266046286,
0.018797045573592186,
-0.001871029962785542,
-0.0013714904198423028,
0.04853012040257454,
0.025270121172070503,
-0.05398616939783096,
0.043050140142440796,
-0.010529217310249805,
-0.05594843253493309,
-0.033837076276540756,
0.009428435936570168,
-0.01203680969774723,
-0.008447304368019104,
0.05623559281229973,
0.02398986555635929,
0.043026212602853775,
0.005471005570143461,
-0.04833868145942688,
0.007783245295286179,
0.01361619308590889,
-0.016224566847085953,
-0.01204279251396656,
0.059537939727306366,
0.00830970611423254,
0.038623083382844925,
0.008148178458213806,
0.00454670749604702,
0.017349278554320335,
-0.001319891307502985,
0.05106670409440994,
-0.012503446079790592,
-0.0036583049222826958,
0.011749649420380592,
0.006550848484039307,
-0.012515410780906677,
-0.010732622817158699,
0.03575148060917854,
0.004986422136425972,
0.0021028523333370686,
-0.019000452011823654,
-0.026466624811291695,
-0.019383331760764122,
0.004824894480407238,
0.009607911109924316,
0.06288814544677734,
-0.04953518137335777,
-0.0027474677190184593,
0.027734916657209396,
0.03891024366021156,
-0.009751491248607635,
-0.05862859636545181,
0.023559123277664185,
-0.011121486313641071,
-0.04702252894639969,
0.01965852826833725,
0.07571464776992798,
-0.023427508771419525,
-0.023762529715895653,
-0.012563270516693592,
0.01442981418222189,
-0.026346974074840546,
0.0031707303132861853,
-0.008596866391599178,
-0.037019770592451096,
-0.00901564210653305,
0.03302345424890518,
0.027710985392332077,
0.0025051760021597147,
0.0028551528230309486,
-0.045993536710739136,
-0.024719731882214546,
0.01988586224615574,
0.03596685081720352,
-0.010810395702719688,
0.02284122258424759,
-0.010792448185384274,
-0.00447491742670536,
0.014298198744654655,
0.01143855880945921,
-0.011558209545910358,
0.0012458576820790768,
0.010104459710419178,
0.0329277329146862,
0.030774030834436417,
-0.009410488419234753,
0.033837076276540756,
0.023152314126491547,
-0.01044546253979206,
0.011665894649922848,
0.0038617101963609457,
0.00973952654749155,
0.008537041954696178,
-0.01684674806892872,
-0.02426506020128727,
-0.026035882532596588,
-0.02869211696088314,
0.008291758596897125,
0.04805152118206024,
-0.015147714875638485,
-0.027950286865234375,
0.016918538138270378,
0.035536110401153564,
-0.026801643893122673,
0.024719731882214546,
-0.006299582775682211,
0.0032993543427437544,
-0.0019876889418810606,
0.029768969863653183,
0.029840759932994843,
0.01643993705511093,
-0.001850091153755784,
-0.013065801933407784,
-0.0009100893512368202,
0.008261846378445625,
0.0002553783997427672,
0.034100305289030075,
0.05738423392176628,
0.008010581135749817,
0.06092588230967522,
0.025198331102728844,
-0.03450711816549301,
-0.02244637720286846,
0.022278867661952972,
-0.055086951702833176,
0.04948732256889343,
-0.02288908325135708,
-0.043193720281124115,
0.013544402085244656,
0.013029906898736954,
0.011091573163866997,
0.01297008153051138,
-0.0035835234448313713,
0.009709613397717476,
0.030702240765094757,
-0.023547159507870674,
-0.009009660221636295,
-0.001693050260655582,
-0.015650246292352676,
0.029338229447603226,
-0.017193732783198357,
-0.012431656010448933,
0.015602385625243187,
0.008824202232062817,
-0.02720845490694046,
0.03144407272338867,
0.0042326259426772594,
-0.02885962836444378,
-0.019251717254519463,
0.00010432001727167517,
0.04508419334888458,
0.026586273685097694,
-0.02256602793931961,
-0.05010950192809105,
0.014896449632942677,
0.009560050442814827,
0.0033771267626434565,
-0.04379197210073471,
-0.00447491742670536,
-0.012467551045119762,
-0.01687067747116089,
-0.02294890768826008,
0.005064194556325674,
-0.0009332715417258441,
-0.026131603866815567,
0.0002772519364953041,
-0.03043900988996029,
0.02869211696088314,
-0.032329484820365906,
-0.027806706726551056,
0.07470958679914474,
0.03651724010705948,
0.04223652184009552,
-0.04242796078324318,
0.025988023728132248,
-0.0033561880700290203,
-0.06733912974596024,
0.018832940608263016,
-0.010110441595315933,
0.0039364914409816265,
0.004385179840028286,
-0.021477211266756058,
0.027878496795892715,
0.015566490590572357,
0.00410400191321969,
0.03285594284534454,
0.03627793863415718,
0.023547159507870674,
0.016248496249318123,
0.018354341387748718,
-0.00972756091505289,
-0.004648410249501467,
0.06437180936336517,
0.006069256458431482,
0.0026427737902849913,
-0.10615365952253342,
0.030941542237997055,
0.0034429344814270735,
-0.023427508771419525,
-0.02251816727221012,
0.026418764144182205,
-0.018617570400238037,
0.015973301604390144,
-0.038359854370355606,
0.056905634701251984,
0.06714769452810287,
-0.0004849572142120451,
0.024839380756020546,
0.05743209645152092,
-0.008082371205091476,
-0.02579658292233944,
0.046017467975616455,
0.013903353363275528,
0.012982046231627464,
0.01044546253979206,
0.010792448185384274,
-0.028069935739040375,
-0.00498941307887435,
-0.04702252894639969,
0.021907951682806015,
0.010092494077980518,
0.06528114527463913,
-0.02282925881445408,
-0.00021929637296125293,
0.03747444227337837,
0.01286239642649889,
0.020005512982606888,
0.005482970271259546,
0.020400358363986015,
0.011342838406562805,
-0.06011226028203964,
0.0003572680288925767,
0.007214907091110945,
0.016918538138270378,
-0.0006771453190594912,
-0.02282925881445408,
-0.053555428981781006,
-0.035631828010082245,
0.0211062952876091,
0.013520472683012486,
-0.044605594128370285,
-0.0166433434933424,
0.009248960763216019,
0.009332715533673763,
0.020364463329315186,
-0.02288908325135708,
-0.003556602168828249,
-0.044653452932834625,
0.023415543138980865,
-0.009452365338802338,
-0.015554525889456272,
-0.011420611292123795,
0.08365941792726517,
0.05408189073204994,
0.04027425870299339,
-0.017612509429454803,
0.0008876548963598907,
0.017361244186758995,
-0.006126089952886105,
-0.0007844566134735942,
-0.02567693218588829,
-0.0164040420204401,
-0.015913477167487144,
0.03658903017640114,
-0.004711226560175419,
-0.0022688668686896563,
0.03287987411022186,
0.00827979389578104,
-0.02582051232457161,
0.0013340996811166406,
-0.04331337288022041,
-0.024767590686678886,
-0.003496777033433318,
0.09567230194807053,
-0.006027378607541323,
-0.013041871599853039,
-0.050588104873895645,
-0.007920843549072742,
-0.002384030260145664,
-0.02706487476825714,
0.009889088571071625,
-0.001570408814586699,
-0.0003327771264594048,
0.017791984602808952,
-0.008590884506702423,
-0.02582051232457161,
0.03905382379889488,
0.03161158412694931,
0.013891387730836868,
-0.008477216586470604,
-0.015470771118998528,
0.03960421681404114,
0.029457878321409225,
-0.04515598341822624,
0.009661753661930561,
0.006772201042622328,
0.004624480381608009,
-0.00908743217587471,
-0.03649330884218216,
0.023595018312335014,
-0.010977906174957752,
0.016344217583537102,
0.017492858693003654,
-0.01215646043419838,
-0.012886326760053635,
0.0009624363156035542,
-0.007723420392721891,
0.03228162229061127,
0.05178460478782654,
0.008943852037191391,
-0.005195809993892908,
0.03034329041838646,
0.007579840254038572,
0.05393831059336662,
0.047764360904693604,
-0.013329031877219677,
0.04276297986507416,
-0.061213042587041855,
-0.0210464708507061,
-0.017301417887210846,
-0.03297559544444084,
-0.020161058753728867,
-0.006443163380026817,
-0.01661941222846508,
0.01805521547794342,
0.015829721465706825,
-0.007430277299135923,
0.0035954883787781,
-0.01047537475824356,
0.030965471640229225,
0.015973301604390144,
-0.029027137905359268,
-0.004708235152065754,
-0.05915505811572075,
0.032520923763513565,
-0.02572479285299778,
-0.002989759435877204,
-0.005782095715403557,
-0.013735842891037464,
-0.026586273685097694,
0.049152303487062454,
-0.04814723879098892,
-0.018976520746946335,
0.01137873437255621,
-0.014585359022021294,
-0.026299113407731056,
0.0035685671027749777,
0.027830636128783226,
-0.020866993814706802,
0.014645184390246868,
0.02434881590306759,
0.005506900604814291,
-0.0031886778306216,
-0.026873433962464333,
-0.007400364615023136,
0.008058440871536732,
-0.0004935570759698749,
-0.0009108371450565755,
-0.05570913106203079,
-0.008034510537981987,
-0.0008869071025401354,
-0.023319823667407036,
0.047764360904693604,
-0.01836630515754223,
-0.038575224578380585,
-0.01431016344577074,
-0.008584901690483093,
0.004445004742592573,
-0.006927746348083019,
0.006808096542954445,
-0.018545780330896378,
-0.00644914573058486,
0.007956738583743572,
-0.00607224740087986,
-0.00842337403446436,
-0.02558121271431446,
0.02095074951648712,
-0.0033173018600791693,
-0.02725631557404995,
-0.011384716257452965,
-0.01659548282623291,
0.013197417370975018,
0.029649319127202034,
-0.011342838406562805,
-0.022171182557940483,
0.02105843462049961,
-0.00990703608840704,
-0.006293600425124168,
-0.046113185584545135,
-0.03197053447365761,
0.026562344282865524,
-0.03673261031508446,
0.04249975085258484,
0.003371144412085414,
-0.010397601872682571,
-0.003667278680950403,
0.0017259541200473905,
0.005734235979616642,
0.017564648762345314,
0.017229627817869186,
-0.0026667038910090923,
-0.026346974074840546,
0.00527956523001194,
0.00491762300953269,
0.0026592256035655737,
-0.0026323043275624514,
-0.006269670557230711,
-0.015542561188340187,
-0.035727549344301224,
0.040106747299432755,
0.011869300156831741,
-0.017289454117417336,
0.03206625208258629,
-0.015638280659914017,
0.011510348878800869,
0.03445925563573837,
0.010331794619560242,
0.01221628487110138,
0.024982960894703865,
-0.017612509429454803,
0.0164638664573431,
0.015087890438735485,
-0.012730780988931656,
-0.020807169377803802,
-0.003410030622035265,
0.014657149091362953,
-0.01957477256655693,
0.0010439479956403375,
-0.01939529739320278,
0.014609289355576038,
0.007214907091110945,
-0.014011038467288017,
-0.03170730173587799,
-0.045921746641397476,
-0.036971911787986755,
0.03589506074786186,
-0.009213065728545189,
-0.0067303236573934555,
-0.005372293759137392,
-0.002307753311470151,
0.007418312132358551,
0.007843070663511753,
0.0032514941412955523,
-0.008213985711336136,
-0.0008682117331773043,
0.0013213868951424956,
-0.008752412162721157,
-0.022099392488598824,
-0.007352504879236221,
0.02099861018359661,
0.020388394594192505,
0.029194649308919907,
0.006652551237493753,
-0.02422916516661644,
0.0016661289846524596,
-0.006191897671669722,
-0.008525076322257519,
-0.012312005273997784,
-0.004908649250864983,
0.013305102474987507,
0.00990703608840704,
0.033956725150346756,
0.008895992301404476,
0.013699947856366634,
-0.03773767128586769,
0.04249975085258484,
0.03290380537509918,
0.005435110069811344,
0.002234467538073659,
-0.002231476129963994,
0.020795203745365143,
-0.009566033259034157,
0.0194790530949831,
0.041422899812459946,
0.020340533927083015,
-0.00602139625698328,
-0.0151357501745224,
0.07499674707651138,
0.014800729230046272,
0.005943623837083578,
-0.0011007818393409252,
0.029481809586286545,
0.026299113407731056,
0.015865616500377655,
-0.0025335929822176695,
0.009554068557918072,
0.029721109196543694,
-0.004256555810570717,
0.028476746752858162,
-0.015985267236828804,
0.015913477167487144,
-0.03048687055706978,
0.028285307809710503,
0.0328080840408802,
0.021967776119709015,
-0.005091115832328796,
-0.03515322878956795,
0.02268567681312561,
0.008782324381172657,
0.006281635258346796,
0.02111826092004776,
-0.028476746752858162,
0.035488247871398926,
-0.015530595555901527,
0.0036343748215585947,
-0.008106300607323647,
-0.03228162229061127,
0.01683478243649006,
0.007669577840715647,
-0.007753333076834679,
-0.03359777480363846,
0.020795203745365143,
0.006144037935882807,
0.03620614856481552,
0.029218578711152077,
0.0020923828706145287,
0.009392540901899338,
-0.01683478243649006,
0.009326732717454433,
-0.012126547284424305,
0.023487333208322525,
-0.027830636128783226,
0.020651623606681824,
0.009924983605742455,
0.0164638664573431,
-0.009416470304131508,
-0.00042475821101106703,
0.01645190268754959,
0.03326275572180748,
-0.044509872794151306,
0.01806717924773693,
0.022087426856160164,
-0.023104453459382057,
-0.0603036992251873,
0.06279242783784866,
0.0001277826668228954,
-0.000993096618913114,
-0.021979741752147675,
-0.0034668645821511745,
0.006144037935882807,
-0.05302896723151207,
-0.026346974074840546,
0.0022269892506301403,
-0.034196026623249054,
-0.050731685012578964,
-0.012658990919589996,
0.028285307809710503,
0.005731244571506977,
-0.014561429619789124,
-0.029936479404568672,
-0.0015719045186415315,
-0.03345419466495514,
0.02437274530529976,
0.001400655135512352,
0.0035296808928251266,
-0.030630450695753098,
-0.009781403467059135,
0.003323284210637212,
0.008578918874263763,
0.0011060165707021952,
-0.007681542541831732,
-0.005375285167247057,
0.009930966421961784,
-0.004863780457526445,
0.01361619308590889,
0.016140811145305634,
-0.03283201530575752,
-0.01652369275689125,
-0.007274731993675232,
0.014489639550447464,
0.01353243738412857,
-0.018605606630444527,
0.002973307389765978,
0.05116242542862892,
0.04132717847824097,
0.015698106959462166,
0.020460184663534164,
-0.010044634342193604,
-0.001450010808184743,
-0.011043713428080082,
-0.0151357501745224,
0.03742658346891403,
-0.01136676874011755,
-0.018485955893993378,
-0.01818682998418808,
0.028404956683516502,
0.020400358363986015,
-0.010965940542519093,
-0.014202478341758251,
-0.029170718044042587,
-0.03175516426563263,
0.016368146985769272,
0.012910256162285805,
0.01520754024386406,
0.008878044784069061,
-0.030558660626411438,
-0.01499217003583908,
0.01125908363610506,
0.010882185772061348,
-0.05140172690153122,
0.0120009146630764,
-0.015530595555901527,
0.007131151854991913,
0.010989870876073837,
-0.09083843231201172,
-0.011588121764361858,
0.017696265131235123,
-0.0002929560432676226,
-0.028309237211942673,
0.013927282765507698,
0.012371830642223358,
0.01421444397419691,
0.01069672778248787,
-0.04178185015916824,
-0.010170266963541508,
0.0064072683453559875,
-0.004591576289385557,
-0.04127931967377663,
0.020017478615045547,
-0.02251816727221012,
-0.03445925563573837,
-0.03807269409298897,
0.013795668259263039,
0.0419732891023159,
0.009930966421961784,
-0.008704552426934242,
-0.020914854481816292,
0.03019971027970314,
-0.03795304149389267,
0.02862032689154148,
0.03003220073878765,
-0.04393555223941803,
-0.028333166614174843,
0.029457878321409225,
0.009213065728545189,
-0.009865159168839455,
-0.03625401109457016,
0.01958673819899559,
-0.009356645867228508,
-0.03821627423167229,
0.018354341387748718,
0.007400364615023136,
0.00988310668617487,
0.007549927569925785,
-0.00011320030898787081,
0.05025308206677437,
0.03421995788812637,
0.01360422745347023,
-0.025078682228922844,
-0.03960421681404114,
-0.020771274343132973,
-0.009709613397717476,
-0.010194197297096252,
0.012563270516693592,
0.0286442581564188,
0.01658351719379425,
-0.026921294629573822,
0.0039873430505394936,
0.007382417097687721,
-0.019120100885629654,
-0.03436353802680969,
0.027830636128783226,
0.028046006336808205,
0.017109978944063187,
0.01971835270524025,
0.052263207733631134,
0.03668475151062012,
-0.024528291076421738,
-0.0053663114085793495,
-0.019419226795434952,
0.015434876084327698,
0.06250526756048203,
-0.06599905341863632,
-0.0480036586523056,
-0.010529217310249805,
-0.000039984664908843115,
-0.013436716981232166,
0.01943119242787361,
-0.015554525889456272,
0.009548085741698742,
-0.017468929290771484,
-0.0015868607442826033,
-0.003843762679025531,
-0.027974216267466545,
0.027567405253648758,
-0.02890748716890812,
-0.014441778883337975,
-0.024552220478653908,
-0.007926825433969498,
0.01950298249721527,
0.00719695957377553,
0.028189586475491524,
0.0017289454117417336,
-0.004791990388184786,
0.03780946135520935,
-0.035440389066934586,
-0.008554989472031593,
-0.01428623404353857,
0.007053379435092211,
-0.01665530726313591,
-0.009709613397717476,
-0.0043791974894702435,
0.02415737509727478,
-0.019024381414055824,
0.03338240459561348,
-0.007107221987098455,
0.003849745262414217,
-0.04204507917165756,
-0.013592262752354145,
0.006431198213249445,
0.025222262367606163,
-0.014669114723801613,
-0.009996773675084114,
0.0022778406273573637,
0.0274956151843071,
0.008219968527555466,
-0.03206625208258629,
0.04424664378166199,
0.007759315427392721,
0.035248950123786926,
0.017301417887210846,
0.0164638664573431,
-0.006371373310685158,
-0.0034429344814270735,
0.040178537368774414,
-0.017456963658332825,
-0.040178537368774414,
-0.032329484820365906,
-0.013317067176103592,
-0.031037261709570885,
0.024863312020897865,
0.0023496306966990232,
-0.0037271035835146904,
0.004663366358727217,
0.02249423786997795,
0.008572936989367008,
-0.010134371928870678,
0.015159680508077145,
0.029840759932994843,
0.04111180827021599,
-0.00014666497008875012,
0.05010950192809105,
0.018473990261554718,
0.0099190017208457,
-0.008399443700909615,
0.006897834129631519,
-0.004839850589632988,
-0.01789966970682144,
0.008836166933178902,
0.013795668259263039,
-0.04879334941506386,
0.0009130805847235024,
-0.020220883190631866,
-0.03369349613785744,
0.041422899812459946,
0.0423322394490242,
0.015734001994132996,
0.03441139683127403,
0.04943946376442909,
0.03780946135520935,
-0.013867458328604698,
-0.0011217206483706832,
-0.03209018334746361,
0.04671143740415573,
0.010158302262425423,
0.04503633454442024,
-0.06489826738834381,
-0.03498571738600731,
-0.0010185223072767258,
-0.02728024497628212,
0.010947993025183678,
-0.02701701410114765,
0.016368146985769272,
-0.007902896031737328,
0.020615728572010994,
-0.03460283577442169,
0.007789228111505508,
-0.017791984602808952,
-0.021632755175232887,
0.003655313514173031,
-0.0032185902819037437,
-0.03503357991576195,
0.021465245634317398,
0.008907957002520561,
0.0007309879292733967,
0.008590884506702423,
0.0041518621146678925,
-0.031085122376680374,
0.01669120229780674,
-0.012359865941107273,
0.015734001994132996,
-0.008925904519855976,
-0.004786008037626743,
-0.026155533269047737,
0.020280709490180016,
0.0002961342397611588,
0.0363018698990345,
0.02704094536602497,
-0.007627699989825487,
-0.02584444358944893,
-0.017815914005041122,
0.04398341476917267,
0.0015838694525882602,
-0.011576157063245773,
-0.04819510132074356,
0.015853650867938995,
0.032736293971538544,
0.0007792219403199852,
-0.004878737032413483,
-0.0010746082989498973,
0.018856871873140335,
-0.01371191255748272,
-0.02711273543536663,
0.015626316890120506,
-0.013843527995049953,
0.032736293971538544,
-0.024552220478653908,
0.01684674806892872,
0.00010609607124933973,
-0.01976621337234974,
-0.00009936575224855915,
0.001612286432646215,
-0.04290656000375748,
0.002213528612628579,
-0.03656510263681412,
-0.041710060089826584,
-0.03297559544444084,
-0.01671513356268406,
-0.021704545244574547,
0.02434881590306759,
0.02260192297399044,
0.020364463329315186,
0.00012591313861776143,
0.01055314764380455,
-0.015398981049656868,
0.023200172930955887,
0.001622755778953433,
0.007813158445060253,
-0.007454207167029381,
0.010056599043309689,
-0.02127380482852459,
0.01211458258330822,
0.0029284385964274406,
0.007220889441668987,
0.04996592178940773,
0.030797962099313736,
0.009045555256307125,
-0.02270960807800293,
-0.023965934291481972,
-0.021907951682806015,
0.05561341345310211,
-0.02124987542629242,
-0.0019084207015112042,
0.010792448185384274,
-0.009470312856137753,
0.026753785088658333,
0.024695800617337227,
0.04544314369559288,
0.01946708746254444,
0.010026686824858189,
-0.0023735607974231243,
0.000428497267421335,
0.007262767292559147,
-0.0026816600002348423,
0.00909341499209404,
-0.02450435981154442,
0.02426506020128727,
0.013771737925708294,
-0.022087426856160164,
0.004717208910733461,
0.0025276103988289833,
-0.01218637265264988,
0.05456048995256424,
0.04857797920703888,
0.019383331760764122,
0.01428623404353857,
-0.025030821561813354,
0.032425202429294586,
0.0037809463683515787,
-0.021824195981025696,
-0.012096635065972805,
-0.05135386437177658,
-0.03374135494232178,
-0.028333166614174843,
0.0006554587744176388,
-0.01684674806892872,
-0.029433948919177055,
0.024767590686678886,
0.008004598319530487,
-0.021477211266756058,
-0.0027295202016830444,
-0.006622638553380966,
-0.023008733987808228,
0.010349742136895657,
-0.02558121271431446,
0.030726170167326927,
-0.032377343624830246,
-0.02414540946483612,
-0.02119005098938942,
-0.015602385625243187,
0.006939711514860392,
0.002636791206896305,
0.02728024497628212,
-0.00524367019534111,
0.0008315689046867192,
0.02422916516661644,
0.009542102925479412,
0.0127547113224864,
0.05929863825440407,
0.004636445082724094,
-0.009817298501729965,
0.006215828005224466,
0.009219047613441944,
0.01524343527853489,
-0.009183152578771114,
0.005832947324961424,
0.026394834741950035,
-0.0016272426582872868,
-0.012060740031301975,
-0.001458236831240356,
-0.02735203504562378,
-0.01374780759215355,
-0.004355267155915499,
0.02842888794839382,
-0.034267816692590714,
-0.025270121172070503,
-0.002524619223549962,
0.0334063358604908,
-0.04063320904970169,
-0.011839387007057667,
0.01671513356268406,
-0.0022284849546849728,
-0.0011463984847068787,
-0.0179116353392601,
-0.030917610973119736,
0.008058440871536732,
-0.0017947530141100287,
-0.010116424411535263,
0.010367689654231071,
0.023762529715895653,
0.039891377091407776,
0.013664052821695805,
0.012335935607552528,
-0.049343742430210114,
-0.018785081803798676,
-0.003007706953212619,
0.008291758596897125,
0.015769897028803825,
0.007669577840715647,
-0.009476295672357082,
-0.007466172333806753,
-0.014633219689130783,
-0.03613435849547386,
-0.003745051333680749,
0.052311066538095474,
-0.0017439016373828053,
-0.006138055119663477,
0.009954896755516529,
0.005776113364845514,
-0.01830648072063923,
-0.012658990919589996,
0.0014298198511824012,
-0.03479427844285965,
0.023846285417675972,
-0.0008225951460190117,
0.06614263355731964,
0.01967049203813076,
-0.003410030622035265,
-0.03005613014101982,
-0.018462026491761208,
-0.017612509429454803,
0.01506396010518074,
-0.005791069474071264,
0.012371830642223358,
-0.021584896370768547,
-0.005013343412429094,
-0.01951494812965393,
-0.029338229447603226,
-0.009446383453905582,
-0.010565112344920635,
0.03637365996837616,
0.04230831190943718,
0.055134810507297516,
0.023499298840761185,
-0.032784152776002884,
0.01421444397419691,
-0.005264608655124903,
0.005916702561080456,
-0.05121028423309326,
-0.00981131661683321,
0.008788307197391987,
-0.025389771908521652,
-0.006323513109236956,
-0.0008210995001718402,
0.011001835577189922,
-0.010983888059854507,
0.01431016344577074,
0.009930966421961784,
-0.019359402358531952,
-0.0011007818393409252,
-0.014262303709983826,
0.021979741752147675,
0.010804412886500359,
-0.006544865667819977,
-0.010355724953114986,
0.0060004573315382,
0.02998434007167816,
0.020436253398656845,
-0.02099861018359661,
0.008776342496275902,
-0.003685226198285818,
0.011959037743508816,
-0.002336170058697462,
0.02261388674378395,
-0.025078682228922844,
0.023212138563394547,
-0.049152303487062454,
0.02249423786997795,
-0.00031894256244413555,
0.01215047761797905,
-0.011127468198537827,
0.029745038598775864,
-0.04443808272480965,
-0.0006476066773757339,
0.02128577046096325,
-0.02732810564339161,
0.044820964336395264,
0.003329266794025898,
-0.05556555092334747,
-0.0026637124828994274,
0.0038168414030224085,
0.0018201787024736404,
-0.01810307428240776,
0.014812694862484932,
0.0023316831793636084,
-0.03608649969100952,
0.01836630515754223,
0.006317530293017626,
-0.03795304149389267,
0.0287639070302248,
0.01661941222846508,
0.02596409246325493,
-0.024959031492471695,
-0.002744476543739438,
-0.013939248397946358,
0.015470771118998528,
0.037163350731134415,
0.018856871873140335,
0.00303612370043993,
-0.006963641382753849,
-0.02426506020128727,
-0.00983524601906538,
0.03491392731666565,
0.02115415595471859,
-0.002168659819290042,
0.005159914959222078,
-0.013185451738536358,
-0.029433948919177055,
-0.01673906296491623,
0.03510536998510361,
-0.02261388674378395,
-0.040011025965213776,
0.04352874308824539,
0.0023346745874732733,
-0.01051126979291439,
0.0001706884941086173,
0.010924063622951508,
-0.005031290929764509,
0.009829264134168625,
0.03768981248140335,
0.000940749712754041,
0.009972844272851944,
-0.007053379435092211,
-0.0046035414561629295,
-0.020531974732875824,
0.01655958779156208,
-0.005919693503528833,
-0.006628620903939009,
-0.04137503728270531,
-0.01984996721148491,
0.015123785473406315,
0.017062118276953697,
0.0036463397555053234,
-0.011851352639496326,
-0.009631841443479061,
0.026825575157999992,
-0.012030827812850475,
0.024456501007080078,
0.007777262944728136,
0.015889545902609825,
0.018713291734457016,
-0.038407713174819946,
0.013592262752354145,
-0.004241599701344967,
-0.0003023036988452077,
-0.01836630515754223,
0.020376428961753845,
-0.03517716005444527,
0.02589230239391327,
-0.04068106785416603,
-0.01663137786090374,
0.00026509998133406043,
-0.008333636447787285,
0.0302715003490448,
-0.001719971653074026,
0.005689367186278105,
-0.012168425135314465,
-0.029074998572468758,
0.028404956683516502,
-0.0043911621905863285,
-0.06915781646966934,
-0.04948732256889343,
-0.02895534783601761,
0.02574872225522995,
0.0010723648592829704,
-0.007454207167029381,
-0.02584444358944893,
0.032449133694171906,
0.029601458460092545,
-0.02403772436082363,
-0.012587200850248337,
0.03534466773271561,
0.041710060089826584,
0.019909793511033058,
-0.01817486435174942,
0.011959037743508816,
0.01794753037393093,
-0.012730780988931656,
-0.05010950192809105,
-0.029745038598775864,
-0.011468471959233284,
0.007113204337656498,
-0.008872061967849731,
0.025222262367606163,
0.02439667470753193,
0.0027669109404087067,
0.037163350731134415,
-0.001382707618176937,
-0.031228702515363693,
0.0271366648375988,
-0.03484213724732399,
0.0012929699150845408,
-0.02888355776667595,
-0.010714675299823284,
0.015482735820114613,
-0.034028515219688416,
0.03144407272338867,
0.01648779772222042,
0.0033143104519695044,
-0.008447304368019104,
0.04118359833955765,
-0.05432118847966194,
-0.03046294115483761,
0.015111819840967655,
0.014860554598271847,
-0.0005313216825015843,
0.00827381107956171,
-0.007364469580352306,
-0.0039005964063107967,
-0.02099861018359661,
-0.013329031877219677,
0.018773116171360016,
0.010714675299823284,
-0.00040830631041899323,
-0.02120201475918293,
0.01658351719379425,
0.021860091015696526,
0.0164040420204401,
-0.004768060520291328,
-0.01368798315525055,
0.00824988167732954,
-0.009398522786796093,
0.0009003677405416965,
-0.0026936251670122147,
0.020184988155961037,
0.03034329041838646,
-0.000883168017026037,
-0.018438095226883888,
-0.003475838340818882,
0.029266439378261566,
-0.0183304101228714,
-0.027639195322990417,
0.0038587190210819244,
-0.024492396041750908,
-0.035248950123786926,
0.009314768016338348,
-0.01141462940722704,
-0.02895534783601761,
-0.02266174741089344,
-0.007310627028346062,
-0.0040980190970003605,
0.026155533269047737,
0.008441321551799774,
0.002385525731369853,
-0.024576151743531227,
-0.0001461041101720184,
-0.025341911241412163,
-0.0029179691337049007,
0.007322592195123434,
0.006736306007951498,
-0.01823469065129757,
0.016894608736038208,
-0.028069935739040375,
0.006084212567657232,
0.0058060260489583015,
0.013903353363275528,
-0.00991301890462637,
-0.017397139221429825,
-0.017600543797016144,
-0.026562344282865524,
-0.013233312405645847,
0.007992633618414402,
-0.018856871873140335,
-0.001790266134776175,
-0.0010237570386379957,
-0.02718452550470829,
-0.02871604822576046,
-0.018868835642933846,
-0.0005350607098080218,
0.01517164520919323,
-0.02711273543536663,
-0.009278872981667519,
0.0042296345345675945,
0.015985267236828804,
0.02582051232457161,
0.025294052436947823,
-0.01133087370544672,
-0.023930039256811142,
-0.007280714809894562,
-0.006646568421274424,
0.027615265920758247,
-0.022003671154379845,
0.030774030834436417,
-0.02107040025293827,
-0.013281172141432762,
0.02708880417048931,
0.0195388775318861,
0.011629999615252018,
-0.006132072769105434,
-0.03745051100850105,
-0.032257694751024246,
-0.013209382072091103,
-0.014621254056692123,
0.02092682011425495,
-0.0035296808928251266,
0.025030821561813354,
-0.03498571738600731,
0.009715596213936806,
-0.03235341235995293,
0.04199722036719322,
-0.013053836300969124,
-0.001727449707686901,
-0.0005832947208546102,
-0.006353425793349743,
-0.03644545003771782,
0.03520108759403229,
0.012467551045119762,
0.01666727289557457,
0.0143819535151124,
-0.025030821561813354,
-0.01975424773991108,
0.012670955620706081,
-0.050635963678359985,
0.01649976335465908,
0.011677859351038933,
-0.029410019516944885,
0.008178090676665306,
0.031109051778912544,
-0.010062581859529018,
0.018557745963335037,
0.013257241807878017,
0.023056592792272568,
0.006885868962854147,
0.0022883100900799036,
0.01129497867077589,
-0.005779104772955179,
0.0043103983625769615,
-0.025988023728132248,
0.10730230063199997,
0.00607823021709919,
-0.04443808272480965,
-0.0031767128966748714,
0.005904737394303083,
-0.0009886097395792603,
0.03759409114718437,
0.005276573821902275,
0.011205241084098816,
-0.00531546026468277,
-0.049248021095991135,
-0.008943852037191391,
0.0396760068833828,
0.03833592310547829,
-0.013209382072091103,
0.01787574030458927,
0.02275746874511242,
0.014034967869520187,
0.015494700521230698,
-0.014669114723801613,
0.015482735820114613,
0.03639759123325348,
-0.015889545902609825,
0.015554525889456272,
-0.0258683729916811,
-0.009619875811040401,
0.0004262538277544081,
0.003870683955028653,
0.01684674806892872,
-0.022350657731294632,
0.0011912672780454159,
-0.000253508856985718,
0.01286239642649889,
-0.008447304368019104,
0.0005354346358217299,
-0.03005613014101982,
-0.0029643336310982704,
-0.006766218692064285,
0.006598708685487509,
0.026107672601938248,
-0.013173487037420273,
0.057958558201789856,
-0.04929588362574577,
-0.009045555256307125,
-0.02401379495859146,
0.012347900308668613,
-0.03031936101615429,
0.007244819775223732,
0.024695800617337227,
-0.009105379693210125,
0.020232848823070526,
0.0017229628283530474,
0.005635524168610573,
0.018509885296225548,
-0.01830648072063923,
-0.007920843549072742,
0.0067961313761770725,
0.018426131457090378,
0.021668650209903717,
-0.01961066760122776,
-0.011181310750544071,
0.032473064959049225,
0.04783615097403526,
-0.006532900966703892,
0.011283013969659805
] | 2024-07-17 | 134 | 39017904 | [
"Aortic valve disease",
"valve disease",
"T cells",
"cardiovascular disease",
"Immune cell therapy",
"diseases",
"cardiac fibrosis",
"targeted T-cell therapy",
"the aortic valve leaflets",
"surgical intervention",
"mainstay therapeutics",
"novel targets",
"mineralisation inhibitors",
"a multi-faceted disease",
"chimeric antigen receptor",
"cardiac research",
"limited success",
"AVD",
"lipid nanoparticles",
"a novel T cell-based therapeutic approach",
"fibrosis",
"the diseased valve",
"subsequent mineralization",
"immunomodulatory strategies",
"considerable risk",
"the valve",
"center stage",
"statins",
"clonally expanded T-cell populations",
"blood"
] | [
"Aortic valve disease",
"Calcification",
"Cardiovascular disease",
"Immune response",
"T cells"
] | 0 | 10.1007/s10557-024-07608-7 | [
"Bartoli-Leonard",
"Pennel",
"Caputo"
] | [
"Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK. [email protected].\nBristol Heart Institute, University Hospital Bristol and Weston NHS Foundation Trust, Bristol, UK. [email protected].\nChris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa. [email protected].",
"Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa.",
"Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK.\nBristol Heart Institute, University Hospital Bristol and Weston NHS Foundation Trust, Bristol, UK."
] | [
"39017904",
"25140960",
"34857095",
"37395329",
"8000586",
"11257080",
"15967862",
"18592926",
"32223336",
"27188578",
"33046623",
"15967862",
"34432007",
"36003161",
"37038246",
"25189570",
"20435842",
"37488920",
"33914604",
"37213100",
"7594080",
"38253304",
"37848296",
"38142218",
"37391604",
"37692547",
"35059444",
"32954917",
"34849696",
"32160774",
"34569705",
"29348122",
"30796046",
"31050556",
"21871458",
"26937229",
"25675999",
"24812352",
"28283241",
"19221394",
"24048120",
"26491108",
"30071238",
"16534030",
"32425433",
"33914601",
"24669254",
"34458332",
"37116353",
"38279441",
"25838429",
"28097522",
"24340842",
"32639511",
"29727769",
"30276357",
"31722535",
"25463124",
"31591603",
"19741337",
"32938214",
"28130912",
"20601388",
"32708790",
"24121974",
"9568715",
"9714144",
"19203752",
"24903093",
"35581364",
"19729866",
"23573943",
"33396395",
"29258711",
"30101853",
"22896576",
"21617136",
"10869258",
"7732003",
"15888166",
"23774666",
"38665903",
"36727519",
"37057097",
"33086873",
"30335148",
"15120829",
"27236112",
"12607654",
"24631773",
"33173427",
"32286271",
"29323337",
"31402927",
"28431214",
"20074454",
"37339188",
"33453490",
"33781847",
"33050133",
"30946962",
"31144065",
"33334888",
"32054669",
"32526213",
"31047003",
"28153876",
"15944423",
"20048204",
"25457756",
"22974804",
"25132377",
"20863951",
"25752438",
"15886380",
"28845751",
"33914606",
"33601919",
"24445487",
"32176778",
"28636844",
"34990237",
"33504774",
"35228742",
"10580495",
"19332877",
"34030769",
"29972754",
"30680780",
"26169254",
"33824268",
"34043424",
"32555459",
"30666307"
] | [] | 7.480076 | 4.341703 |
39016046 | 719 | CAR-T cells for H3K27-altered diffuse midline gliomas: where do we stand? | null | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-17 | 17 | 39016046 | [] | [
"B7-H3",
"CAR-T cell",
"GD2",
"blood–brain barrier",
"diffuse midline glioma"
] | 0 | 10.1080/1750743X.2024.2373043
10.1080/14728222.2023.2277232
10.1158/0008-5472.Can-13-1491
10.1038/nature10833
10.1200/jco.2009.25.5463
10.3389/fonc.2018.00191
10.1007/s00381-019-04363-1
10.3390/cancers15030602
10.1016/j.trecan.2023.07.007
10.1038/s41408-021-00459-7
10.1038/s41586-023-05707-3
10.1016/j.ebiom.2020.102931
10.1158/2767-9764.Crc-23-0424
10.7150/ijbs.85813
10.1158/2159-8290.Cd-22-0750
10.1038/s41591-018-0006-x
10.1038/s41586-022-04489-4 | [
"Power",
"Millesi",
"Rechberger",
"Daniels"
] | [
"Loyola University Chicago Stritch School of Medicine, Maywood, IL 60141, USA.",
"Division of Plastic & Reconstructive Surgery, Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA.\nResearch Laboratory of the Division of Plastic & Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna 1090, Austria.",
"Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA.\nDepartment of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905,USA.",
"Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA.\nDepartment of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905,USA."
] | [
"39016046",
"37897190",
"23970477",
"22286061",
"20142589",
"29904623",
"31489454",
"36765560",
"37541803",
"33824268",
"36813894",
"32739874",
"37971169",
"37564196",
"36259971",
"29662203",
"35130560"
] | [] | 32.944782 | 7.54911 |
39013724 | 720 | Vaccine-based immunotherapy and related preclinical models for glioma. | Glioma, the most common primary malignant tumor in the central nervous system (CNS), lacks effective treatments, and >60% of cases are glioblastoma (GBM), the most aggressive form. Despite advances in immunotherapy, GBM remains highly resistant. Approaches that target tumor antigens expedite the development of immunotherapies, including personalized tumor-specific vaccines, patient-specific target selection, dendritic cell (DC) vaccines, and chimeric antigen receptor (CAR) and T cell receptor (TCR) T cells. Recent studies show promising results in treating GBM and lower-grade glioma (LGG), fostering hope for future immunotherapy. This review discusses tumor vaccines against glioma, preclinical models in immunological research, and the role of CD4 | [
-0.004461301025003195,
0.013370680622756481,
0.07332718372344971,
0.04755900427699089,
-0.046416569501161575,
-0.04375089704990387,
0.015570919029414654,
0.05276341363787651,
-0.030464841052889824,
0.00896491389721632,
0.012746574357151985,
-0.009551997296512127,
-0.0207435954362154,
0.0036943908780813217,
0.0005289035034365952,
-0.04032360389828682,
0.0410640686750412,
-0.03937157616019249,
0.00885913334786892,
0.0042074271477758884,
0.015010281465947628,
0.020225269719958305,
-0.030274435877799988,
-0.009176475927233696,
-0.040598634630441666,
-0.012810043059289455,
0.0011450761230662465,
0.014089989475905895,
-0.02346215955913067,
0.001812816713936627,
0.0006763353594578803,
-0.0019159528892487288,
0.0008614515536464751,
-0.02549314871430397,
-0.020193535834550858,
-0.008356675505638123,
-0.008631705306470394,
0.001298458082601428,
-0.015676699578762054,
0.03812336549162865,
0.0088855791836977,
-0.019728099927306175,
-0.017612487077713013,
0.051620982587337494,
-0.027545293793082237,
0.004024955444037914,
0.02830691635608673,
-0.0817050114274025,
-0.04218534380197525,
-0.02337753400206566,
0.007817193865776062,
0.05665614455938339,
-0.01612097956240177,
0.06753040105104446,
-0.025260431692004204,
0.022425508126616478,
-0.04408939555287361,
0.0031152416486293077,
-0.0046622841618955135,
0.017549017444252968,
-0.011106973513960838,
-0.005664556287229061,
0.03655780851840973,
-0.024393029510974884,
-0.038313768804073334,
-0.05136710777878761,
-0.03387098014354706,
-0.04140256717801094,
0.01565554365515709,
-0.004577660001814365,
0.0010882189963012934,
-0.06211442872881889,
0.031036056578159332,
0.004670218098908663,
0.02297556772828102,
0.022362040355801582,
0.01212246809154749,
-0.02337753400206566,
0.017485549673438072,
-0.016723928973078728,
-0.01187917310744524,
-0.017199940979480743,
0.03837723657488823,
-0.019178040325641632,
-0.04557032510638237,
0.014248660765588284,
0.004723108373582363,
-0.002618072321638465,
-0.06736115366220474,
-0.03841955214738846,
-0.020680127665400505,
-0.016967223957180977,
-0.029280098155140877,
0.05119786038994789,
-0.02748182602226734,
-0.05593683570623398,
0.04019666463136673,
-0.041127536445856094,
0.031374555081129074,
0.013127384707331657,
0.00412280298769474,
0.02048972249031067,
-0.02619130164384842,
-0.01454484649002552,
0.0752735435962677,
-0.01266194973140955,
-0.0611412450671196,
-0.02454112283885479,
0.005696290638297796,
0.01970694400370121,
0.06372229754924774,
0.013402414508163929,
0.012270561419427395,
-0.0029036803171038628,
-0.03558462858200073,
-0.009747691452503204,
-0.004215361084789038,
-0.031057214364409447,
0.021452326327562332,
0.022404352203011513,
-0.03958313912153244,
0.030993744730949402,
-0.005960742477327585,
-0.04136025533080101,
0.024117998778820038,
-0.04383552074432373,
0.07032301276922226,
-0.040640946477651596,
-0.007166642230004072,
-0.028687726706266403,
0.027672231197357178,
-0.04345471039414406,
0.04590882360935211,
-0.015179530717432499,
-0.08246663212776184,
-0.025789335370063782,
-0.03224195912480354,
0.033236294984817505,
-0.01797214150428772,
0.03004171885550022,
-0.008483611978590488,
-0.014862188138067722,
-0.004678151570260525,
0.0012561457697302103,
-0.003924463875591755,
-0.05335578694939613,
0.0084465891122818,
0.006214616354554892,
0.003723480738699436,
0.014640049077570438,
-0.00979529321193695,
0.04167759418487549,
0.006955081131309271,
-0.007552742026746273,
-0.04552801325917244,
-0.04028129205107689,
-0.013561085797846317,
0.09257926791906357,
-0.029597440734505653,
-0.06934982538223267,
0.009827027097344398,
0.05128248408436775,
0.012672527693212032,
-0.007087307050824165,
0.020627235993742943,
0.046247322112321854,
-0.01261963788419962,
-0.013613976538181305,
-0.025747021660208702,
0.010657405480742455,
0.021632153540849686,
0.002588982693850994,
-0.05090167373418808,
-0.00834609754383564,
-0.041868001222610474,
-0.013973630964756012,
0.008938468992710114,
0.007769592572003603,
-0.02475268393754959,
-0.012841776944696903,
-0.024393029510974884,
0.04169875383377075,
0.01867029443383217,
-0.001346059376373887,
-0.01896647922694683,
0.07480811327695847,
0.002673607086762786,
0.0021380924154073,
-0.05420203134417534,
-0.0007298868149518967,
0.011138707399368286,
-0.04675506800413132,
0.04963230341672897,
0.01063624955713749,
0.012894667685031891,
-0.013836115598678589,
0.04734744131565094,
0.0029248364735394716,
-0.017295144498348236,
0.014671782962977886,
0.011477205902338028,
-0.051959481090307236,
-0.04260846599936485,
-0.022340884432196617,
-0.02050030045211315,
-0.06609178334474564,
0.039308108389377594,
0.05606377124786377,
0.0018339728703722358,
0.04210072010755539,
-0.01222824864089489,
-0.03660012409090996,
0.017549017444252968,
-0.019738677889108658,
-0.007621499244123697,
-0.004344942048192024,
-0.029407035559415817,
0.023864125832915306,
0.032665081322193146,
0.044808704406023026,
0.0396677628159523,
0.006616582628339529,
-0.02796841785311699,
0.04070441424846649,
-0.023419847711920738,
0.005156808998435736,
0.03128993138670921,
-0.01101177092641592,
-0.006865167524665594,
-0.013910162262618542,
-0.0005913802306167781,
-0.009097140282392502,
0.032580453902482986,
-0.03545768931508064,
-0.03306704759597778,
-0.03173420950770378,
0.038313768804073334,
-0.004376676399260759,
0.06676878035068512,
-0.028412695974111557,
0.031247619539499283,
0.021039782091975212,
0.013148540630936623,
-0.0410640686750412,
-0.028455007821321487,
0.0023787436075508595,
-0.00929812341928482,
-0.051705606281757355,
0.00015255559992510825,
0.0013262255815789104,
-0.04730512946844101,
0.004252383951097727,
-0.01266194973140955,
-0.016872022300958633,
0.01574016734957695,
-0.010149658657610416,
-0.00027767434949055314,
0.011508939787745476,
-0.010958880186080933,
-0.013412992469966412,
-0.016713351011276245,
0.018977057188749313,
0.025641242042183876,
-0.038863830268383026,
-0.0456126369535923,
0.0216850433498621,
-0.03260161355137825,
-0.011561830528080463,
0.046628132462501526,
-0.0004932025331072509,
0.01644889824092388,
-0.014343863353133202,
0.022742850705981255,
-0.02796841785311699,
-0.06448391824960709,
-0.019569430500268936,
0.012862932868301868,
0.017051849514245987,
-0.006955081131309271,
0.0387580469250679,
-0.01259848102927208,
-0.001808849978260696,
0.029026223346590996,
-0.03456913307309151,
0.005611666012555361,
0.02259475737810135,
-0.0050219385884702206,
0.03139571100473404,
-0.046501196920871735,
-0.04857449606060982,
0.0037975271698087454,
0.007510429713875055,
-0.0396677628159523,
-0.016596991568803787,
0.020637813955545425,
-0.0041994936764240265,
0.04400477185845375,
0.009118296205997467,
-0.03296126797795296,
0.06490703672170639,
-0.025831647217273712,
-0.007034416776150465,
-0.0030147498473525047,
-0.01387842744588852,
-0.019696366041898727,
0.028730038553476334,
0.008187426254153252,
0.02297556772828102,
0.005627533420920372,
0.007140197325497866,
0.00886442232877016,
-0.028412695974111557,
0.03408254310488701,
0.05153635889291763,
-0.01739034801721573,
0.022002385929226875,
0.003527786349877715,
-0.02003486454486847,
-0.019368445500731468,
-0.006706496234983206,
-0.01094830222427845,
0.013233165256679058,
-0.04292580857872963,
0.024202624335885048,
-0.04072557017207146,
-0.0184693094342947,
-0.01888185553252697,
0.00253609218634665,
0.07150775194168091,
-0.06626103073358536,
0.04916686937212944,
0.02830691635608673,
0.04916686937212944,
0.0030782183166593313,
-0.0023298198357224464,
-0.01627964898943901,
0.01805676519870758,
-0.032368894666433334,
-0.00656898133456707,
-0.0134658832103014,
-0.008129246532917023,
0.0018233947921544313,
-0.012154202908277512,
0.01703069359064102,
-0.004998138174414635,
0.012545591220259666,
0.005167387425899506,
0.0273548886179924,
0.0255354605615139,
-0.002151315100491047,
0.030887965112924576,
0.005405393894761801,
-0.010133790783584118,
0.013666866347193718,
-0.011265644803643227,
-0.01727398857474327,
-0.009414481930434704,
-0.017707688733935356,
0.0410640686750412,
0.001420105923898518,
-0.03128993138670921,
-0.04089481756091118,
-0.00657955976203084,
0.05949106439948082,
0.04722050577402115,
0.07036532461643219,
0.006833433173596859,
0.016247915104031563,
-0.016882600262761116,
-0.008584103547036648,
-0.046416569501161575,
0.023144816979765892,
-0.000029626860850839876,
-0.046374257653951645,
-0.04169875383377075,
0.013846693560481071,
-0.006114124320447445,
0.030761027708649635,
0.0064949351362884045,
0.05597914755344391,
0.06367997825145721,
-0.005527041386812925,
-0.003012105356901884,
-0.019178040325641632,
-0.03890614211559296,
-0.014629471115767956,
0.014259238727390766,
-0.02966090850532055,
-0.0647801011800766,
-0.009694801643490791,
0.010070323012769222,
-0.011424316093325615,
0.022319728508591652,
-0.004384609870612621,
-0.023229442536830902,
0.04127562791109085,
-0.006204037927091122,
0.031099526211619377,
0.0030755738262087107,
0.026000896468758583,
-0.003094085492193699,
-0.025556616485118866,
-0.03949851170182228,
-0.04975924268364906,
0.011593564413487911,
-0.04400477185845375,
0.03207270801067352,
0.0058708288706839085,
0.0012858966365456581,
-0.031755365431308746,
-0.0008594681858085096,
0.043200839310884476,
0.01648063398897648,
0.00797586515545845,
-0.024266092106699944,
-0.02358909696340561,
-0.024816151708364487,
0.042946964502334595,
0.005934297107160091,
0.011805126443505287,
0.031247619539499283,
-0.0022451954428106546,
-0.02454112283885479,
-0.006283373571932316,
-0.01925208792090416,
0.0037895936984568834,
0.039477355778217316,
-0.004651706200093031,
-0.01437559723854065,
-0.03456913307309151,
0.0022227170411497355,
0.035753875970840454,
-0.034188322722911835,
-0.017115317285060883,
0.0044004772789776325,
0.04011204093694687,
-0.04899762198328972,
-0.01780289225280285,
-0.05839094519615173,
0.043031588196754456,
-0.029385877773165703,
-0.051578670740127563,
-0.02904738113284111,
-0.025070026516914368,
0.03676937147974968,
0.009610177017748356,
-0.015750747174024582,
0.034971099346876144,
-0.02011949010193348,
-0.05826400965452194,
0.04006972908973694,
-0.030232124030590057,
0.0271433275192976,
-0.03300357982516289,
-0.03198808431625366,
-0.013730335049331188,
0.06651490181684494,
-0.04163528233766556,
0.01480929832905531,
-0.02363140881061554,
0.03478069603443146,
-0.032157331705093384,
-0.02061665803194046,
-0.04878605902194977,
-0.025218119844794273,
0.0020495010539889336,
0.03744636848568916,
-0.009335147216916084,
0.025133494287729263,
0.013497617095708847,
0.010794920846819878,
0.022742850705981255,
-0.026614423841238022,
-0.007351758889853954,
0.017908671870827675,
0.04066210240125656,
-0.02000313065946102,
-0.019230931997299194,
0.036134686321020126,
-0.0012191225541755557,
-0.014798720367252827,
0.04772825166583061,
-0.03520381823182106,
-0.012915823608636856,
0.010620382614433765,
0.00048328557750210166,
-0.019823303446173668,
-0.022658225148916245,
0.0269317664206028,
0.02784148044884205,
-0.008393698371946812,
-0.025091182440519333,
0.016173869371414185,
-0.006743519566953182,
-0.004024955444037914,
-0.012503278441727161,
-0.01431212853640318,
-0.05250953882932663,
-0.036705903708934784,
0.022319728508591652,
-0.03296126797795296,
0.006209326907992363,
-0.02900506742298603,
-0.014999703504145145,
0.027820324525237083,
-0.0014161390718072653,
0.0017731490079313517,
0.04527413845062256,
0.01417461410164833,
0.03520381823182106,
-0.02908969298005104,
-0.04127562791109085,
0.0085523696616292,
-0.0034986967220902443,
-0.0010664017172530293,
-0.012439810670912266,
-0.013317789882421494,
0.0305706225335598,
0.006928635761141777,
0.009758269414305687,
-0.0014558068942278624,
0.0063415528275072575,
-0.03668474778532982,
-0.014597736299037933,
0.004376676399260759,
-0.008890868164598942,
-0.034357570111751556,
-0.0319034606218338,
-0.009684222750365734,
-0.05741776525974274,
-0.015560341067612171,
-0.029026223346590996,
-0.01872318424284458,
-0.007092596031725407,
-0.02549314871430397,
0.024160312488675117,
-0.029343565925955772,
-0.009927518665790558,
-0.030422529205679893,
-0.0068387221544981,
-0.0022266837768256664,
-0.023652564734220505,
0.021050360053777695,
0.008753352798521519,
-0.0008363286615349352,
0.01726341061294079,
0.023419847711920738,
-0.017115317285060883,
0.005490018520504236,
0.016702773049473763,
0.051917169243097305,
-0.026614423841238022,
0.034103699028491974,
0.0030491286888718605,
0.023948751389980316,
-0.0073729148134589195,
-0.011022348888218403,
-0.007399360183626413,
-0.01497854758054018,
-0.017252832651138306,
-0.0009533485863357782,
-0.02557777427136898,
0.000014792769434279762,
-0.03325745090842247,
0.004585593473166227,
0.006621872074902058,
0.003012105356901884,
0.004091068636626005,
-0.006204037927091122,
-0.011170442216098309,
-0.02396990731358528,
0.02115613967180252,
0.007880662567913532,
-0.03750983625650406,
0.008938468992710114,
-0.00962604396045208,
-0.025789335370063782,
0.012884089723229408,
-0.0008039333042688668,
0.013613976538181305,
-0.017950985580682755,
-0.03550000488758087,
-0.039350420236587524,
0.02614898979663849,
-0.0007483984809368849,
0.024562278762459755,
-0.058644820004701614,
0.017549017444252968,
0.004215361084789038,
-0.013243744149804115,
0.012111890129745007,
-0.021039782091975212,
0.03581734374165535,
-0.04387783631682396,
-0.03004171885550022,
-0.0015153085114434361,
-0.030676404014229774,
-0.032665081322193146,
-0.035753875970840454,
0.02908969298005104,
-0.005696290638297796,
-0.0023443647660315037,
-0.009927518665790558,
-0.016311384737491608,
-0.014248660765588284,
0.028539633378386497,
-0.015253577381372452,
-0.021706199273467064,
0.015380513854324818,
-0.014999703504145145,
0.04201609268784523,
0.0456126369535923,
-0.044470205903053284,
-0.04963230341672897,
-0.010821365751326084,
0.008573525585234165,
-0.015708433464169502,
0.0048315334133803844,
0.07476580142974854,
0.004522124771028757,
-0.016681617125868797,
0.0037155470345169306,
-0.006828144192695618,
-0.006606004666537046,
-0.010556913912296295,
-0.046374257653951645,
-0.013412992469966412,
-0.011572408489882946,
0.0027291420847177505,
-0.026127833873033524,
0.0033347366843372583,
-0.0198656152933836,
0.004561792593449354,
0.02970322035253048,
0.008425433188676834,
-0.006992104463279247,
0.02272169478237629,
-0.008404276333749294,
0.02805304154753685,
0.003670590231195092,
-0.015602652914822102,
0.015644965693354607,
-0.015211264602839947,
-0.029766689985990524,
0.004395188298076391,
-0.015644965693354607,
-0.04573957622051239,
-0.0191357284784317,
-0.01627964898943901,
-0.01315911952406168,
-0.011149285361170769,
-0.03082449547946453,
0.0070132603868842125,
0.011329112574458122,
-0.015666121616959572,
-0.004855334293097258,
0.0028931021224707365,
-0.03482300788164139,
0.024266092106699944,
0.053313471376895905,
-0.012460966594517231,
0.004212716594338417,
0.00577562628313899,
0.0010095445904880762,
-0.0048235999420285225,
0.03467491269111633,
-0.014491955749690533,
-0.02648748829960823,
-0.002007188741117716,
-0.0027476537507027388,
0.05635995790362358,
-0.0045591481029987335,
0.04903993383049965,
-0.008277339860796928,
0.006426177453249693,
0.032580453902482986,
-0.011329112574458122,
-0.021960074082016945,
-0.015687277540564537,
-0.039604295045137405,
0.035098034888505936,
-0.005828516557812691,
-0.019527116790413857,
-0.030189812183380127,
0.029153160750865936,
0.022298570722341537,
0.008943757973611355,
-0.004418988712131977,
0.020468564704060555,
-0.014322706498205662,
0.018987635150551796,
-0.04442789405584335,
-0.0373617447912693,
0.013561085797846317,
-0.040683258324861526,
0.018151968717575073,
0.024604590609669685,
0.016998957842588425,
-0.03820798918604851,
-0.050013113766908646,
-0.002159248571842909,
0.013836115598678589,
0.0031919325701892376,
-0.02519696205854416,
0.03550000488758087,
-0.017549017444252968,
-0.014862188138067722,
0.02306019328534603,
0.0007946775294840336,
-0.027545293793082237,
-0.02991478145122528,
-0.007357047870755196,
0.01078434195369482,
0.01735861226916313,
0.021431170403957367,
-0.024308405816555023,
-0.011128129437565804,
0.05614839494228363,
0.000435023132013157,
0.0054953075014054775,
-0.009657777845859528,
-0.008679306134581566,
-0.002990949200466275,
-0.013899584300816059,
0.02367372065782547,
0.011223332025110722,
-0.07844696938991547,
0.05420203134417534,
-0.027291420847177505,
-0.031459178775548935,
-0.005273167975246906,
0.002696085488423705,
-0.02566239796578884,
-0.0012878800043836236,
-0.04235459119081497,
0.048320624977350235,
0.003977354150265455,
-0.05762932449579239,
-0.0051832543686032295,
-0.01155125256627798,
0.019178040325641632,
0.00592900812625885,
-0.0688420832157135,
-0.039435043931007385,
-0.029809001833200455,
0.03664243593811989,
0.0002533778315410018,
-0.010096767917275429,
0.011456049978733063,
-0.015814214944839478,
0.00411222456023097,
0.004619972314685583,
-0.023081349208950996,
-0.025387367233633995,
0.004781287629157305,
-0.023335222154855728,
-0.014650627039372921,
-0.006288662552833557,
-0.019685788080096245,
-0.020690705627202988,
-0.06131049245595932,
0.0016065443633124232,
-0.0027793878689408302,
-0.0035515869967639446,
-0.017527861520648003,
-0.031014900654554367,
0.022277414798736572,
0.028941599652171135,
-0.006865167524665594,
0.020267581567168236,
-0.006383865140378475,
-0.021748511120676994,
0.014301550574600697,
-0.05724851414561272,
-0.004236517008394003,
-0.0028640124946832657,
-0.0271433275192976,
0.003255401039496064,
-0.007383492775261402,
-0.023208284750580788,
0.01460831519216299,
-0.02246781997382641,
-0.005310191307216883,
0.010726163163781166,
-0.015507450327277184,
-0.004900291096419096,
0.013550507836043835,
0.03772139921784401,
-0.008499478921294212,
-0.0016369563527405262,
0.018067343160510063,
0.018786652013659477,
-0.02809535339474678,
0.042206499725580215,
-0.02094457857310772,
0.020140646025538445,
0.03300357982516289,
-0.053821220993995667,
-0.039435043931007385,
-0.016311384737491608,
-0.02284863218665123,
-0.030020562931895256,
0.009557286277413368,
-0.03325745090842247,
-0.005955453496426344,
0.04590882360935211,
0.014629471115767956,
-0.004654350690543652,
-0.04226996749639511,
-0.008790376596152782,
0.023737188428640366,
0.025027712807059288,
-0.00587611785158515,
-0.03442104160785675,
-0.05284803733229637,
-0.017041271552443504,
0.038652267307043076,
0.001808849978260696,
0.02623361349105835,
-0.02135712280869484,
0.015084328129887581,
0.015941152349114418,
0.0005246061482466757,
-0.0189241673797369,
-0.024921933189034462,
-0.024964245036244392,
-0.029026223346590996,
-0.020024286583065987,
-0.012217670679092407,
-0.041339099407196045,
0.026910610496997833,
-0.02396990731358528,
-0.016639303416013718,
0.020764751359820366,
-0.009964541532099247,
0.05949106439948082,
0.0006849300116300583,
0.031416866928339005,
0.0038054606411606073,
0.03442104160785675,
-0.00748927379027009,
-0.04358164966106415,
-0.008742774836719036,
0.014238081872463226,
0.009287545457482338,
0.02809535339474678,
-0.046797383576631546,
-0.002472623949870467,
-0.04023898020386696,
-0.04616269841790199,
-0.0008422788232564926,
0.00026626986800692976,
-0.04510489106178284,
0.004686085041612387,
0.019400181248784065,
-0.013920740224421024,
0.006024210713803768,
-0.017549017444252968,
0.017950985580682755,
-0.0004211394116282463,
-0.02652980014681816,
-0.032538142055273056,
-0.025683553889393806,
0.010022721253335476,
0.03338439017534256,
-0.02652980014681816,
0.0002897399535868317,
-0.0271433275192976,
-0.0033876269590109587,
-0.030549466609954834,
0.07510429620742798,
0.01283119898289442,
0.004738975316286087,
-0.011572408489882946,
-0.015570919029414654,
0.001104086055420339,
0.04271424561738968,
-0.05085936188697815,
-0.00309937447309494,
-0.027735698968172073,
0.020214691758155823,
-0.007161353249102831,
0.0159517303109169,
0.04430095851421356,
0.0004703935410361737,
-0.0004816327418666333,
-0.0042074271477758884,
0.01656525768339634,
-0.03750983625650406,
-0.002397255040705204,
0.041169848293066025,
0.01817312464118004,
-0.021134983748197556,
0.006997393444180489,
0.0003090779937338084,
-0.01814139075577259,
0.0036150554660707712,
0.033532481640577316,
-0.002220072550699115,
0.0013315145624801517,
-0.00469930749386549,
0.021431170403957367,
-0.044554829597473145,
0.019019369035959244,
0.009171186946332455,
0.027206795290112495,
-0.018162546679377556,
0.029639752581715584,
-0.017739422619342804,
0.029512815177440643,
-0.02925894223153591,
-0.004902935586869717,
0.008970203809440136,
-0.005170031916350126,
-0.020267581567168236,
0.017654798924922943,
-0.04279887303709984,
0.04738975316286087,
0.007494562771171331,
-0.012947557494044304,
-0.004461301025003195,
-0.016046931967139244,
-0.024435341358184814,
-0.0024646902456879616,
0.03135339915752411,
-0.030634090304374695,
0.029639752581715584,
0.012524435296654701,
0.002614105585962534,
0.003215733217075467,
-0.03361710533499718,
-0.0012349897297099233,
-0.005585221108049154,
-0.02027815952897072,
0.03342670202255249,
0.028814662247896194,
-0.015687277540564537,
0.015401669777929783,
-0.016586413607001305,
0.00400908850133419,
0.008404276333749294,
0.008901446126401424,
-0.008599970489740372,
-0.03894845396280289,
-0.009557286277413368,
0.014692938886582851,
-0.014946812763810158,
-0.00577562628313899,
0.0021473481319844723,
0.027693387120962143,
0.04548570141196251,
0.032157331705093384,
0.02796841785311699,
0.022510133683681488,
-0.00486591225489974,
-0.05250953882932663,
0.018501045182347298,
0.0017030693124979734,
0.00599247682839632,
-0.028370384126901627,
-0.03389213606715202,
-0.015496872365474701,
-0.01105408277362585,
-0.01448137778788805,
0.01437559723854065,
0.010297751054167747,
0.018744340166449547,
-0.0010968135902658105,
-0.02454112283885479,
0.05644458159804344,
0.019146306440234184,
0.005706868600100279,
0.02908969298005104,
-0.020669549703598022,
-0.013190853409469128,
0.002385354833677411,
0.004149247892200947,
0.017496127635240555,
0.004387254361063242,
0.0035330753307789564,
0.029512815177440643,
0.017326878383755684,
-0.0369386188685894,
-0.02301787957549095,
-0.031713053584098816,
0.0187126062810421,
-0.01730572246015072,
-0.012154202908277512,
-0.015190108679234982,
0.0004323786124587059,
0.03437872603535652,
0.028539633378386497,
-0.024075686931610107,
0.0009817770915105939,
0.038652267307043076,
-0.03376520052552223,
-0.02428724803030491,
-0.01148778386414051,
0.02987246960401535,
0.023864125832915306,
-0.04442789405584335,
-0.02602205239236355,
0.03090912103652954,
0.006124702747911215,
-0.04565494880080223,
-0.06905364245176315,
0.015338202007114887,
-0.028581945225596428,
0.03391329199075699,
-0.015359357930719852,
0.00838840939104557,
-0.020881110802292824,
0.026593267917633057,
0.022510133683681488,
0.014428487978875637,
-0.04053516313433647,
-0.011413737200200558,
0.01096945907920599,
-0.025810491293668747,
0.0015814214712008834,
-0.025556616485118866,
-0.006172304041683674,
0.021420592442154884,
0.0173163004219532,
-0.004569726064801216,
-0.01703069359064102,
0.017549017444252968,
0.0028507898095995188,
0.04023898020386696,
0.025747021660208702,
0.014777563512325287,
-0.013444727286696434,
0.03503456711769104,
-0.009377459064126015,
0.0012733351904898882,
-0.00014420883962884545,
0.0035436535254120827,
0.04425864666700363,
0.041952624917030334,
-0.0013044083025306463,
-0.05259416252374649,
0.00486326776444912,
0.019527116790413857,
0.044597141444683075,
-0.041085224598646164,
-0.03581734374165535,
-0.02358909696340561,
0.0018630626145750284,
0.02462574653327465,
0.008970203809440136,
0.009451505728065968,
-0.011889751069247723,
0.020214691758155823,
0.010234282352030277,
0.009800582192838192,
0.031501494348049164,
0.0029195472598075867,
0.011043504811823368,
-0.03380751237273216,
-0.04349702224135399,
-0.008298495784401894,
0.041994936764240265,
0.031078370288014412,
0.005106563214212656,
-0.03376520052552223,
-0.007759014144539833,
0.002160570817068219,
0.020214691758155823,
-0.0020495010539889336,
-0.02826460264623165,
-0.018955901265144348,
0.019241509959101677,
-0.03209386393427849,
-0.004691374022513628,
-0.02102920413017273,
-0.0012045777402818203,
-0.018575090914964676,
-0.020267581567168236,
-0.003422005567699671,
0.004001155029982328,
0.0013334979303181171,
0.038821518421173096,
0.008065778762102127,
-0.008208582177758217,
-0.028074197471141815,
0.01374091301113367,
-0.02061665803194046,
-0.023271754384040833,
0.010821365751326084,
0.006923346780240536,
-0.01326490007340908,
-0.005706868600100279,
-0.030316749587655067,
0.015793059021234512,
-0.01168876700103283,
-0.007320024538785219,
-0.030993744730949402,
-0.005484729539602995,
0.007161353249102831,
0.007066150661557913,
0.010821365751326084,
-0.004405766259878874,
-0.011424316093325615,
-0.0009169864351861179,
-0.04011204093694687,
-0.003940331283956766,
0.02623361349105835,
-0.05424434319138527,
0.021335966885089874,
0.020997468382120132,
0.013275478035211563,
0.014756407588720322,
0.011900329031050205,
0.019389603286981583,
0.009144741110503674,
0.02085995487868786,
0.005595799069851637,
0.008213871158659458,
-0.011181020177900791,
-0.025387367233633995,
-0.02087053284049034,
0.0049743372946977615,
-0.010937724262475967,
0.004889712668955326,
0.03355363756418228,
-0.027714543044567108,
-0.03211501985788345,
0.04205840826034546,
0.0027502982411533594,
0.010451133362948895,
-0.036663591861724854,
0.01817312464118004,
0.010154947638511658,
-0.02354678325355053,
0.015412247739732265,
0.011466627940535545,
-0.02648748829960823,
-0.004786576610058546,
0.005484729539602995,
0.011646455153822899,
0.02987246960401535,
0.0017797602340579033,
-0.008314362727105618,
-0.00047237693797796965,
-0.02215047925710678,
0.016967223957180977,
-0.018977057188749313,
0.040090885013341904,
-0.030993744730949402,
-0.035098034888505936,
0.04747437685728073,
0.048447560518980026,
0.01020254846662283,
0.03302473574876785,
-0.01315911952406168,
-0.017083583399653435,
0.021431170403957367,
-0.01387842744588852,
0.013455305248498917,
-0.004818310961127281,
-0.02684714086353779,
-0.008711040951311588,
0.006024210713803768,
-0.011561830528080463,
-0.02036278508603573,
-0.0010207837913185358,
-0.011329112574458122,
-0.013286055997014046,
0.05035161226987839,
-0.048278313130140305,
-0.02165330946445465,
0.003617699956521392,
0.018522201105952263,
0.05318653583526611,
0.007997021079063416,
-0.004805088508874178,
0.01239749789237976,
-0.03979469835758209,
0.0008039333042688668,
-0.00331622501835227,
-0.0030200390610843897,
0.0032448230776935816,
-0.0072777122259140015,
-0.06397616863250732,
0.008467745035886765,
0.027651075273752213,
0.030591778457164764,
0.02623361349105835,
0.01460831519216299,
0.009610177017748356,
-0.008309073746204376,
0.017866360023617744,
-0.030210968106985092,
0.017326878383755684,
0.011032926850020885,
0.0009665711550042033,
0.014269816689193249,
-0.031586118042469025,
-0.004757487215101719,
0.0018154613208025694,
-0.0016118334606289864,
0.021060938015580177,
0.004746908787637949,
0.0030570621602237225,
0.031036056578159332,
-0.003723480738699436,
0.001734803430736065,
-0.013360102660953999,
-0.0064949351362884045,
-0.0423969030380249,
0.01673450693488121,
-0.007827771827578545,
-0.014714095741510391,
-0.003488118527457118,
-0.03040137328207493,
-0.03304589167237282,
-0.02619130164384842,
-0.0001461095962440595,
-0.03272854909300804,
0.027524137869477272,
-0.000033469674235675484,
-0.019601164385676384,
-0.004024955444037914,
-0.00748927379027009,
0.028433851897716522,
-0.027904948219656944,
0.018352951854467392,
0.03767908364534378,
-0.03222080320119858,
0.008039332926273346,
0.010313617996871471,
-0.007970576174557209,
-0.019410759210586548,
-0.008007599040865898,
-0.021621575579047203,
-0.023144816979765892,
0.000007370559615083039,
0.012037843465805054,
0.046543508768081665,
0.0007735213730484247,
-0.00818213727325201,
0.031332243233919144,
-0.026466330513358116,
0.002635261742398143,
0.0010842521442100406,
0.006405021529644728,
0.010149658657610416,
0.007314735557883978,
0.04789750277996063,
-0.023144816979765892,
-0.002376098884269595,
-0.012386919930577278,
-0.0010664017172530293,
-0.007965287193655968,
0.021293655037879944,
0.044724080711603165,
0.010096767917275429,
-0.015549763105809689,
0.00592900812625885,
-0.007790748495608568,
-0.01649121195077896,
0.022954411804676056,
0.0006479067960754037,
0.014597736299037933,
0.017083583399653435,
-0.029068537056446075,
-0.014967968687415123,
0.022319728508591652,
0.020711861550807953,
-0.011932062916457653,
-0.0011503651039674878,
0.004588237963616848,
-0.030020562931895256,
0.02396990731358528,
0.029809001833200455,
0.00861583836376667,
-0.022573601454496384,
-0.031374555081129074,
0.02788379229605198,
-0.003691746387630701,
-0.00029321087640710175,
0.02259475737810135,
0.008949046954512596,
0.04000626131892204,
-0.004704596474766731,
0.05305960029363632,
0.026614423841238022,
-0.011181020177900791,
0.003303002333268523,
-0.014862188138067722,
0.010588647797703743,
-0.000248915224801749,
0.0006680712103843689,
0.0034563844092190266,
-0.007658522576093674,
-0.013116806745529175,
-0.010313617996871471,
-0.012683105655014515,
-0.0016065443633124232,
-0.002198916394263506,
-0.015359357930719852,
0.022658225148916245,
0.010990615002810955,
0.007843638770282269,
-0.055344462394714355,
-0.016205603256821632,
-0.017876937985420227,
-0.039646606892347336,
0.009282256476581097,
-0.019283821806311607,
0.0355423167347908,
0.04161412641406059,
0.020553190261125565,
-0.001856451272033155,
0.041085224598646164,
-0.0013387870276346803,
-0.0034378727432340384,
0.03484416380524635,
0.03317282721400261,
0.01681913062930107,
-0.0053895264863967896,
-0.017009535804390907,
-0.01945307105779648,
-0.005627533420920372,
0.025789335370063782,
-0.01611040160059929,
0.01817312464118004,
0.024943089112639427,
-0.010493445210158825,
-0.007579187396913767,
-0.01883954182267189,
-0.028983911499381065,
0.0019199197413399816,
0.007346469443291426,
0.0119637968018651,
-0.020045442506670952,
0.0006941858446225524,
-0.026297081261873245,
0.01862798072397709,
-0.016745084896683693,
-0.0022557734046131372,
-0.007933552376925945,
0.013582241721451283,
0.03200924023985863,
-0.027524137869477272,
0.005074829328805208,
-0.002155281836166978,
0.048278313130140305,
-0.007087307050824165,
0.009340436197817326,
0.007378203794360161,
-0.023419847711920738,
0.026677893474698067,
0.0168931782245636,
0.026762517169117928,
-0.028814662247896194,
0.024054531008005142,
0.02085995487868786,
0.0008799632196314633,
-0.003250112058594823,
0.03619815409183502,
0.011001192964613438,
0.005405393894761801,
0.04370858520269394,
-0.010096767917275429,
0.002397255040705204,
0.0013751491205766797,
-0.014037098735570908,
-0.012513856403529644,
0.01747497171163559,
0.026825984939932823,
-0.04709356650710106,
-0.005955453496426344,
-0.003562165191397071,
0.011995531618595123,
0.006426177453249693,
-0.010403531603515148,
-0.006674762349575758,
-0.021790824830532074,
-0.004731041844934225,
-0.0041915602050721645,
-0.006896901875734329,
-0.028645412996411324,
-0.028074197471141815,
-0.024921933189034462,
-0.01858566887676716,
-0.017379768192768097,
-0.055598337203264236,
0.02631823904812336,
-0.017824048176407814,
-0.009060117416083813,
0.013899584300816059,
0.005162097979336977,
-0.009176475927233696,
-0.027799168601632118,
-0.01681913062930107,
0.028645412996411324,
-0.0031099526677280664,
0.025175806134939194,
-0.04730512946844101,
-0.018733762204647064,
0.017115317285060883,
0.025027712807059288,
-0.036578964442014694,
-0.011286800727248192,
-0.013085072860121727,
0.01653352379798889,
-0.02215047925710678,
0.0014650627272203565,
0.028370384126901627,
0.021378278732299805,
0.017136473208665848,
0.03524613007903099,
-0.03884267434477806,
-0.007129619363695383,
0.016099821776151657,
0.012196514755487442,
0.017591331154108047,
0.01648063398897648,
-0.024943089112639427,
-0.0364520289003849,
-0.02701639011502266,
0.019072260707616806,
-0.019897349178791046,
0.008636994287371635,
0.033405546098947525,
0.020733017474412918,
-0.020056020468473434,
0.005976609420031309,
0.008959624916315079,
-0.024562278762459755,
-0.016385430470108986,
-0.005122430622577667,
-0.023991063237190247,
0.013391836546361446,
-0.03528844192624092,
0.007346469443291426,
0.029385877773165703,
-0.016099821776151657,
-0.016089243814349174,
-0.0011589598143473268,
-0.04218534380197525,
-0.004575015511363745,
0.006584848742932081,
-0.02813766710460186,
0.01565554365515709,
-0.019929083064198494,
-0.0205320343375206,
0.008827399462461472,
0.004873845726251602,
0.020955156534910202,
0.028497321531176567,
0.041423723101615906,
0.013804381713271141,
-0.008351386524736881,
-0.020881110802292824,
0.00022478398750536144,
0.009023093618452549,
0.006156436633318663,
-0.011614721268415451,
0.010874255560338497,
-0.008562947623431683,
-0.0022438731975853443,
0.02606436423957348,
-0.008541791699826717,
-0.014798720367252827,
-0.001441262080334127,
-0.01063624955713749,
0.01283119898289442,
-0.029766689985990524,
-0.0037102580536156893,
0.058814071118831635,
-0.018828963860869408,
-0.021261921152472496,
-0.005833805538713932,
-0.015676699578762054,
-0.0024951023515313864,
0.039688918739557266,
-0.03086680918931961,
0.01239749789237976,
-0.001778437988832593,
0.0173163004219532,
-0.0025122915394604206,
0.012535013258457184,
0.052001792937517166,
-0.0064949351362884045,
-0.025302743539214134,
-0.02272169478237629,
0.0008647572249174118,
0.002402544254437089,
-0.0337228886783123,
0.0026035273913294077,
0.018807807937264442,
0.008933180011808872,
0.023314066231250763,
-0.004905580077320337,
0.010255439206957817,
0.0008951691561378539,
-0.005796782206743956,
-0.026254769414663315,
-0.00566984573379159,
-0.014830454252660275,
0.008769219741225243,
0.005849672947078943,
-0.0015258865896612406,
0.012492700479924679,
-0.007044994737952948,
-0.029428191483020782,
-0.02887813188135624,
-0.011604142375290394,
0.020934000611305237,
0.005881406832486391,
-0.006801698822528124,
-0.0010915246093645692,
-0.018405841663479805,
-0.0011543318396434188,
0.026656735688447952,
0.0038662846200168133,
-0.0010624348651617765,
-0.00486326776444912,
-0.014502533711493015,
0.025641242042183876,
-0.0056063770316541195,
0.021663887426257133,
0.002258417895063758,
0.006505513098090887,
0.003977354150265455,
0.038863830268383026,
-0.012133046053349972,
0.005516463425010443,
-0.033447857946157455,
-0.03179767727851868,
0.03152265027165413,
0.026000896468758583,
-0.023335222154855728,
0.013730335049331188
] | 2024-07-17 | 1 | 39013724 | [
"tumor vaccines",
"tumor antigens",
"chimeric antigen receptor",
"T cell receptor",
"GBM",
"future immunotherapy",
"dendritic cell",
"personalized tumor-specific vaccines",
"immunotherapies",
"immunotherapy",
"promising results",
"immunological research",
"effective treatments",
"preclinical models",
"Recent studies",
"glioblastoma",
"LGG",
"cases",
"patient-specific target selection",
"CNS",
"glioma",
"the most common primary malignant tumor",
"hope",
"DC) vaccines",
"lower-grade glioma",
"CAR",
"the central nervous system",
"CD4",
"Glioma",
"advances"
] | [
"glioma",
"immunotherapy",
"preclinical models",
"tumor antigen",
"vaccines"
] | 0 | 10.1016/j.molmed.2024.06.009 | [
"Yao",
"Hatami",
"Ma",
"Skutella"
] | [
"Institute for Anatomy and Cell Biology, Heidelberg Medical Faculty, Heidelberg University, Heidelberg, Germany.",
"Institute for Anatomy and Cell Biology, Heidelberg Medical Faculty, Heidelberg University, Heidelberg, Germany.",
"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.",
"Institute for Anatomy and Cell Biology, Heidelberg Medical Faculty, Heidelberg University, Heidelberg, Germany. Electronic address: [email protected]."
] | [
"39013724"
] | [] | 10.199984 | 7.426176 |
39013470 | 721 | Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis. | Allogeneic chimeric antigen receptor (CAR)-T cells hold great promise for expanding the accessibility of CAR-T therapy, whereas the risks of allograft rejection have hampered its application. Here, we genetically engineered healthy-donor-derived, CD19-targeting CAR-T cells using CRISPR-Cas9 to address the issue of immune rejection and treated one patient with refractory immune-mediated necrotizing myopathy and two patients with diffuse cutaneous systemic sclerosis with these cells. This study was registered at ClinicalTrials.gov (NCT05859997). The infused cells persisted for over 3 months, achieving complete B cell depletion within 2 weeks of treatment. During the 6-month follow-up, we observed deep remission without cytokine release syndrome or other serious adverse events in all three patients, primarily shown by the significant improvement in the clinical response index scores for the two diseases, respectively, and supported by the observations of reversal of inflammation and fibrosis. Our results demonstrate the high safety and promising immune modulatory effect of the off-the-shelf CAR-T cells in treating severe refractory autoimmune diseases. | [
0.025689059868454933,
0.01966637559235096,
0.03432929143309593,
0.07662706077098846,
-0.026685118675231934,
-0.020616106688976288,
-0.06282121688127518,
0.013099335134029388,
0.009109308011829853,
-0.031016817316412926,
0.0004878952167928219,
-0.024901477620005608,
-0.03539484366774559,
-0.015832707285881042,
0.05031256750226021,
-0.025272104889154434,
0.042946361005306244,
-0.03750278428196907,
0.005061370320618153,
0.029858609661459923,
0.0346304252743721,
0.024229716509580612,
-0.021936465054750443,
-0.0312252938747406,
-0.015716886147856712,
-0.013875334523618221,
0.029742788523435593,
0.0036194007843732834,
0.009618919342756271,
-0.037294305860996246,
0.010574441403150558,
-0.010753964073956013,
-0.020986733958125114,
0.0019515808671712875,
-0.023036763072013855,
0.029395325109362602,
0.05021991208195686,
-0.009618919342756271,
-0.04037513956427574,
-0.03808188810944557,
0.052397340536117554,
0.005906862206757069,
0.025040462613105774,
0.08987696468830109,
-0.06351613998413086,
-0.008958741091191769,
-0.009526262991130352,
-0.04021299257874489,
0.03669203817844391,
0.0013884021900594234,
-0.01854291372001171,
0.006636533420532942,
-0.06889022886753082,
0.03293944150209427,
-0.024785656481981277,
0.03245299682021141,
-0.02282828465104103,
-0.0023033865727484226,
-0.012462320737540722,
0.013076171278953552,
0.015658976510167122,
-0.0036657291930168867,
0.027750669047236443,
-0.03286994993686676,
-0.0258280448615551,
0.005912653170526028,
-0.03335639834403992,
0.0009504546760581434,
-0.004823937546461821,
0.04794982075691223,
-0.03157275542616844,
-0.009520472027361393,
0.0249941349029541,
-0.023812761530280113,
0.03393550217151642,
0.0010669993935152888,
0.018218616023659706,
0.03646039590239525,
0.02911735512316227,
-0.007956890389323235,
0.01341205183416605,
0.04623567312955856,
-0.013944827020168304,
-0.05415781959891319,
0.0006529398960992694,
-0.016770856454968452,
0.01920309290289879,
-0.02359270304441452,
-0.0343756228685379,
0.0039263260550796986,
-0.014570259489119053,
0.032846786081790924,
-0.06407207995653152,
0.05670587718486786,
-0.0007358241709880531,
0.015994856134057045,
-0.028862548992037773,
-0.05207304283976555,
0.0326383076608181,
0.026106014847755432,
0.05786408483982086,
0.006485966499894857,
0.0166087057441473,
-0.016342317685484886,
0.0386146642267704,
0.0069145034067332745,
-0.030553534626960754,
-0.004163758829236031,
0.0272410586476326,
-0.004905011970549822,
0.07116031646728516,
-0.011431515216827393,
0.020928822457790375,
0.04785716533660889,
-0.015473661944270134,
-0.05689118802547455,
-0.05429680272936821,
-0.0366225466132164,
0.012717126868665218,
0.040815260261297226,
-0.00821748748421669,
0.05587196722626686,
0.03773442655801773,
-0.01819545216858387,
-0.022631390020251274,
-0.02594386599957943,
0.08441022038459778,
-0.024669835343956947,
-0.06430372595787048,
-0.06435005366802216,
0.016388647258281708,
0.0047602360136806965,
0.03168857842683792,
0.0031792817171663046,
-0.08691194653511047,
0.009954799897968769,
-0.0017561332788318396,
-0.044058240950107574,
-0.04660630226135254,
-0.017280466854572296,
0.016539214178919792,
-0.03481573984026909,
-0.0009171561687253416,
0.025990193709731102,
-0.01408381201326847,
-0.04021299257874489,
0.019504226744174957,
0.016573959961533546,
-0.0334722176194191,
0.037595439702272415,
-0.0496639721095562,
0.05119280517101288,
0.05633524805307388,
0.0029186848551034927,
0.003937907982617617,
-0.0717625841498375,
-0.003599132178351283,
0.06337715685367584,
-0.041046902537345886,
-0.04218194633722305,
-0.019735869020223618,
-0.004751549568027258,
-0.03087783232331276,
-0.029904937371611595,
0.014964050613343716,
-0.004960027057677507,
0.005866324994713068,
0.03930958732962608,
-0.06481333076953888,
0.022446075454354286,
0.0017981183482334018,
-0.015369423665106297,
-0.09409283846616745,
0.004349071998149157,
-0.0825570821762085,
0.017454197630286217,
0.0354643352329731,
0.019979093223810196,
-0.017106736078858376,
-0.03974970802664757,
0.01044703833758831,
-0.00963050127029419,
0.02078983746469021,
0.01230017188936472,
-0.026383984833955765,
0.021982792764902115,
-0.012288589961826801,
0.021172046661376953,
-0.02805180475115776,
-0.019515808671712875,
0.027796998620033264,
-0.022434493526816368,
0.041463855654001236,
-0.022805120795965195,
0.02941848896443844,
-0.03409765288233757,
0.03930958732962608,
0.023268403485417366,
-0.0166087057441473,
-0.06374778598546982,
0.03754911199212074,
-0.028677236288785934,
-0.031202130019664764,
0.03175806999206543,
-0.009288830682635307,
-0.009010860696434975,
-0.012867693789303303,
0.03428296372294426,
-0.03275413066148758,
0.0023960433900356293,
0.04097740724682808,
0.012485485523939133,
-0.024901477620005608,
0.019515808671712875,
-0.020743509754538536,
-0.02464667148888111,
0.01391008123755455,
0.035186365246772766,
0.010603396221995354,
0.015392587520182133,
-0.0264071486890316,
-0.037363797426223755,
-0.0033588039223104715,
0.026870431378483772,
-0.01329623069614172,
-0.015137782320380211,
0.0010192232439294457,
0.0016576856141909957,
0.011419933289289474,
-0.0203033909201622,
-0.019226256757974625,
0.04382660239934921,
0.018241779878735542,
-0.05526969954371452,
-0.013655275106430054,
-0.021994374692440033,
0.044868987053632736,
0.009723158553242683,
0.05994885787367821,
-0.040467794984579086,
0.005466742906719446,
0.009723158553242683,
0.02453085035085678,
-0.01226542517542839,
-0.00462125102058053,
-0.002962117549031973,
-0.00685080187395215,
-0.06138503924012184,
0.010777127929031849,
0.012960350140929222,
-0.03852200508117676,
0.012983514927327633,
0.013238320127129555,
-0.018473422154784203,
0.01667819917201996,
0.01871664635837078,
0.013632111251354218,
-0.030553534626960754,
-0.011634201742708683,
0.006572831887751818,
-0.018925122916698456,
-0.030669353902339935,
-0.04523961618542671,
-0.009601546451449394,
-0.018867213279008865,
0.017292048782110214,
0.018207034096121788,
0.033727023750543594,
0.03838302195072174,
-0.009091935120522976,
0.031595923006534576,
0.014466021209955215,
0.031132638454437256,
-0.024669835343956947,
-0.05276796966791153,
0.030715683475136757,
0.012763455510139465,
0.023372642695903778,
-0.033078428357839584,
0.006902921013534069,
-0.018531331792473793,
0.020928822457790375,
0.011199873872101307,
-0.03963388502597809,
-0.029974428936839104,
-0.0026291327085345984,
0.008929785341024399,
-0.00035216769902035594,
-0.0122075155377388,
-0.062126290053129196,
-0.02376643382012844,
-0.007707876153290272,
-0.0073372493498027325,
-0.01597169227898121,
-0.00400450499728322,
0.011576291173696518,
-0.04079209640622139,
0.01860082522034645,
-0.01655079610645771,
0.004490952473133802,
-0.03523269668221474,
0.020847748965024948,
0.026754610240459442,
0.0012059843866154552,
0.005935817491263151,
0.02418338879942894,
-0.010128531605005264,
-0.012450738810002804,
0.02506362646818161,
0.04331699013710022,
0.004230355843901634,
0.0036136098206043243,
0.016423393040895462,
0.021438434720039368,
0.005649160593748093,
0.01614542305469513,
0.014176469296216965,
-0.06309918314218521,
0.01597169227898121,
-0.02835293859243393,
-0.025503745302557945,
0.006578622851520777,
-0.01523043867200613,
0.016527632251381874,
0.002837610198184848,
-0.018010137602686882,
0.020118078216910362,
-0.032545652240514755,
0.022295508533716202,
-0.04239042103290558,
0.03138744458556175,
-0.047579195350408554,
0.059717219322919846,
-0.014269125647842884,
-0.0016591333551332355,
0.008599696680903435,
-0.06027315929532051,
-0.033425889909267426,
0.036367740482091904,
-0.01937682367861271,
-0.008194323629140854,
0.04361812397837639,
-0.07213321328163147,
0.054204147309064865,
0.026152342557907104,
-0.02517944760620594,
-0.0004010296252090484,
-0.0023207596968859434,
0.01452393177896738,
0.020523451268672943,
0.013991155661642551,
0.016828766092658043,
0.0015925363404676318,
0.004120325669646263,
-0.020963570103049278,
0.03685418516397476,
-0.040653109550476074,
0.015381005592644215,
-0.013423633761703968,
-0.004742862656712532,
0.018519749864935875,
0.04315483942627907,
-0.037664931267499924,
0.035834964364767075,
0.0857074111700058,
0.034074485301971436,
-0.041348036378622055,
0.056196264922618866,
-0.04248308017849922,
-0.039124276489019394,
-0.013215156272053719,
-0.0023294463753700256,
0.010279098525643349,
0.01920309290289879,
-0.03998135030269623,
0.004635728430002928,
0.011917962692677975,
0.007690502796322107,
0.021229958161711693,
-0.012068530544638634,
0.04308534786105156,
-0.03856833651661873,
-0.036645710468292236,
-0.04266839101910591,
-0.017986973747611046,
0.0001274933893000707,
0.01907568983733654,
-0.0001867610844783485,
-0.055964622646570206,
0.021033061668276787,
-0.017685839906334877,
-0.020639270544052124,
-0.004276684019714594,
-0.015415752306580544,
0.005660742986947298,
0.06106073781847954,
-0.008356472477316856,
0.05387984961271286,
0.05513071268796921,
0.00974632240831852,
0.004349071998149157,
-0.022283926606178284,
-0.021287867799401283,
-0.05059053748846054,
0.018322855234146118,
0.006422264967113733,
0.02148476243019104,
0.011871634982526302,
0.012033783830702305,
-0.0274032074958086,
0.002061610808596015,
-0.005353817716240883,
0.028978370130062103,
-0.008605487644672394,
0.01350470818579197,
-0.04679161310195923,
-0.0474170446395874,
0.05188773199915886,
-0.027194730937480927,
0.02235342003405094,
0.027611684054136276,
-0.023615866899490356,
0.011941127479076385,
-0.03750278428196907,
0.007018742151558399,
-0.004789191298186779,
0.026800939813256264,
0.016353901475667953,
0.0019530287245288491,
-0.036946844309568405,
-0.04686110466718674,
0.03914744034409523,
-0.01572846807539463,
-0.04327066242694855,
-0.0016794019611552358,
0.06972413510084152,
-0.017384706065058708,
0.013551036827266216,
-0.05633524805307388,
0.03479257598519325,
-0.013516290113329887,
-0.0009620367200113833,
-0.012288589961826801,
-0.020106496289372444,
0.03249932453036308,
-0.008483875542879105,
0.011228828690946102,
0.013655275106430054,
-0.05059053748846054,
0.007024533115327358,
-0.0025784610770642757,
-0.020407630130648613,
0.008570740930736065,
-0.023928582668304443,
-0.03564964979887009,
-0.013655275106430054,
0.012172768823802471,
-0.05415781959891319,
0.01731521263718605,
0.032429832965135574,
0.03099365346133709,
-0.02988177351653576,
0.007858443073928356,
0.005174295511096716,
0.010904530994594097,
0.023685358464717865,
0.029302669689059258,
-0.004302743822336197,
-0.0024886999744921923,
-0.03949490189552307,
0.005287220701575279,
-0.022492405027151108,
-0.0352095328271389,
0.007273547817021608,
-0.010018501430749893,
0.03998135030269623,
0.010470203123986721,
0.011582083068788052,
0.020060166716575623,
0.009838978759944439,
-0.026036521419882774,
-0.010302262380719185,
-0.006410682573914528,
0.003648356068879366,
0.0616166777908802,
0.02575855143368244,
-0.002343924017623067,
-0.014037484303116798,
-0.018809301778674126,
0.05809572711586952,
0.02487831376492977,
0.0025205507408827543,
0.02575855143368244,
-0.010134322568774223,
0.007366204634308815,
-0.00664811534807086,
0.03497789055109024,
0.0027131028473377228,
-0.03377335146069527,
0.020268645137548447,
0.025434253737330437,
0.0337965153157711,
0.0060284738428890705,
0.013991155661642551,
0.015682140365242958,
0.04614301770925522,
0.027217894792556763,
0.06712975353002548,
-0.012971932999789715,
0.02693992480635643,
-0.0035383261274546385,
0.008842919953167439,
0.01750052720308304,
-0.02253873273730278,
-0.04273788630962372,
-0.007186682429164648,
-0.062311604619026184,
-0.005411728285253048,
-0.031966548413038254,
-0.008599696680903435,
-0.01076554600149393,
-0.007661547511816025,
-0.006092175375670195,
0.01249706745147705,
0.011367813684046268,
-0.01907568983733654,
-0.03622875362634659,
-0.00598793663084507,
-0.0425988994538784,
-0.02224918082356453,
0.03646039590239525,
-0.0031792817171663046,
0.038823142647743225,
0.04072260111570358,
-0.02246924117207527,
-0.02366219460964203,
-0.033657532185316086,
0.037942901253700256,
0.004852892830967903,
-0.016099095344543457,
0.01350470818579197,
-0.0197242870926857,
0.015253602527081966,
-0.024021239951252937,
0.0025755655951797962,
0.019411571323871613,
0.006219578441232443,
-0.028908878564834595,
-0.006775518413633108,
-0.015427334234118462,
-0.00006609931006096303,
-0.02066243626177311,
0.0006594548467546701,
-0.0018560286844149232,
0.012462320737540722,
-0.020650852471590042,
-0.005408832803368568,
-0.023789597675204277,
-0.008617069572210312,
-0.015948528423905373,
-0.015519990585744381,
-0.0012530365493148565,
0.004045042209327221,
-0.006323817186057568,
-0.014315454289317131,
-0.0017083571292459965,
0.00714614475145936,
-0.011732649989426136,
-0.018415510654449463,
0.0005258989403955638,
-0.022816702723503113,
-0.00011129657650599256,
-0.005211937241256237,
-0.01279820129275322,
0.04776450991630554,
0.05008092522621155,
-0.028491923585534096,
0.01707199029624462,
0.004288265947252512,
0.012531813234090805,
-0.024345537647604942,
-0.030437713488936424,
-0.0032429832499474287,
0.06944616883993149,
-0.019029362127184868,
0.04618934541940689,
-0.05151710286736488,
-0.01937682367861271,
-0.0071056075394153595,
0.0026609834749251604,
0.01490614004433155,
0.031364280730485916,
0.035186365246772766,
0.011234620586037636,
-0.029742788523435593,
0.0264071486890316,
0.01596011035144329,
0.014303872361779213,
-0.009311994537711143,
-0.01381742488592863,
0.003923430573195219,
-0.04855209216475487,
-0.013029842637479305,
-0.03734063357114792,
-0.00689713004976511,
0.04095424339175224,
-0.010707635432481766,
-0.017037242650985718,
-0.006943458691239357,
0.003741012653335929,
0.05471375957131386,
0.04855209216475487,
-0.0188903771340847,
0.004821042064577341,
0.04107006639242172,
0.012392828240990639,
-0.022642971947789192,
-0.011692112311720848,
0.03393550217151642,
-0.02059294283390045,
-0.01777849718928337,
-0.0020326555240899324,
-0.004821042064577341,
0.016446556895971298,
-0.009062979370355606,
-0.030252398923039436,
0.001229148474521935,
-0.0033645951189100742,
-0.002873804187402129,
0.009977963753044605,
0.014755573123693466,
-0.01015748642385006,
-0.021218376234173775,
0.03432929143309593,
-0.018531331792473793,
-0.043571796268224716,
0.04435937479138374,
-0.005501489154994488,
-0.013493126258254051,
-0.0024438195396214724,
-0.030298728495836258,
0.007383577525615692,
0.04621250927448273,
-0.016701363027095795,
0.02788965404033661,
0.0045343851670622826,
-0.01953897252678871,
0.009584173560142517,
0.011257784441113472,
0.005527548957616091,
-0.028329774737358093,
-0.019944345578551292,
0.00892399437725544,
-0.018809301778674126,
0.0029375057201832533,
-0.021704822778701782,
0.007951099425554276,
-0.009728949517011642,
0.06138503924012184,
0.06430372595787048,
-0.02999759465456009,
0.025503745302557945,
-0.021855389699339867,
-0.0034688336309045553,
-0.022156523540616035,
-0.029557473957538605,
-0.0007340144948102534,
0.001250141067430377,
-0.007725249044597149,
0.0015027752378955483,
0.12369664013385773,
0.0012146709486842155,
-0.0006268802098929882,
-0.027866490185260773,
-0.010250142775475979,
-0.011987455189228058,
0.0058634295128285885,
-0.008350681513547897,
0.002885386347770691,
-0.004360653925687075,
-0.0051627131178975105,
0.0038568335585296154,
-0.019921181723475456,
-0.04975662752985954,
-0.004673370160162449,
-0.016527632251381874,
0.0188903771340847,
0.01249706745147705,
-0.0015896408585831523,
-0.018797719851136208,
0.006132712587714195,
-0.015485244803130627,
-0.027310550212860107,
-0.00025100543280132115,
0.04322433099150658,
0.02846875973045826,
-0.00883133802562952,
-0.024391865357756615,
-0.018577661365270615,
0.0008085741428658366,
0.02536476030945778,
0.03833669424057007,
0.0306461900472641,
-0.01662028767168522,
0.015519990585744381,
-0.009439397603273392,
0.001553446869365871,
-0.02846875973045826,
0.013377305120229721,
0.014964050613343716,
0.012242261320352554,
-0.019585302099585533,
-0.02548058144748211,
-0.03423663601279259,
-0.024113895371556282,
0.009925845079123974,
0.010099575854837894,
0.0320592038333416,
0.0036975799594074488,
0.006011100951582193,
0.008871875703334808,
0.010916112922132015,
-0.018450258299708366,
-0.012427574954926968,
0.02717156521975994,
0.02770434133708477,
-0.03585812821984291,
0.06536927074193954,
-0.02800547517836094,
-0.013967991806566715,
0.009404650889337063,
-0.019677957519888878,
-0.01806804910302162,
0.003419609973207116,
-0.03646039590239525,
0.01209169439971447,
-0.005356713198125362,
-0.019156765192747116,
-0.009972172789275646,
-0.009613128378987312,
0.012971932999789715,
-0.023453718051314354,
-0.03868415579199791,
0.02564273029565811,
-0.028862548992037773,
0.01473240926861763,
0.03801239654421806,
0.004844205919653177,
-0.014014319516718388,
-0.01826494373381138,
-0.011049306951463223,
0.007736830972135067,
-0.028190789744257927,
-0.010337009094655514,
-0.008136413060128689,
-0.028839385136961937,
0.008674980141222477,
0.00012061653251294047,
-0.04113955795764923,
-0.034769412130117416,
-0.00871551688760519,
0.03678469359874725,
0.013863752596080303,
0.008072711527347565,
-0.0003599494230002165,
-0.0027956252451986074,
0.0073951599188148975,
0.03326374292373657,
-0.025573238730430603,
0.019214674830436707,
-0.004603877663612366,
-0.020222315564751625,
-0.002246923977509141,
0.009485725313425064,
-0.010001128539443016,
-0.007493607234209776,
-0.0007010779227130115,
-0.0021962523460388184,
-0.0029968637973070145,
0.015357841737568378,
-0.01026751659810543,
0.00789318885654211,
-0.009375696070492268,
0.013666857033967972,
-0.015357841737568378,
-0.004204296041280031,
-0.0018415511585772038,
0.008906621485948563,
-0.018832465633749962,
-0.023025181144475937,
-0.02135736122727394,
0.01684034802019596,
-0.03569597750902176,
0.05012725293636322,
-0.015716886147856712,
0.017407869920134544,
0.022492405027151108,
-0.09186907857656479,
-0.014975632540881634,
-0.008397010155022144,
-0.0053682951256632805,
-0.009589964523911476,
-0.0018314168555662036,
-0.03134111687541008,
-0.0020963570568710566,
0.007128771860152483,
-0.00954363588243723,
0.011622619815170765,
-0.018809301778674126,
0.00664811534807086,
0.015994856134057045,
0.005970563739538193,
0.002225207630544901,
-0.04984928295016289,
-0.044220391660928726,
-0.0009214994497597218,
0.037664931267499924,
0.010777127929031849,
0.010024292394518852,
-0.020384466275572777,
0.034491442143917084,
-0.002364192623645067,
-0.006375936325639486,
-0.00874447263777256,
-0.016990914940834045,
-0.04961764067411423,
0.0011379396310076118,
0.02025706321001053,
-0.005475429352372885,
-0.013053007423877716,
0.01543891616165638,
-0.009728949517011642,
-0.03493156284093857,
0.033495381474494934,
-0.009219338186085224,
-0.005927130579948425,
0.020152823999524117,
-0.015519990585744381,
0.03138744458556175,
0.024855149909853935,
-0.007238801568746567,
-0.01784798875451088,
0.013574200682342052,
-0.015311513096094131,
0.014049066230654716,
0.013690021820366383,
-0.02946481853723526,
0.03377335146069527,
-0.024669835343956947,
-0.015253602527081966,
0.016342317685484886,
-0.01636548340320587,
-0.010522321797907352,
-0.014396528713405132,
0.037896573543548584,
-0.006410682573914528,
0.009190382435917854,
-0.017570018768310547,
0.05980987474322319,
0.05230468511581421,
-0.023349478840827942,
-0.00771945808082819,
-0.0077599952928721905,
-0.04438254237174988,
0.02717156521975994,
-0.03110947459936142,
0.0073372493498027325,
-0.0374564565718174,
0.0013116708723828197,
-0.02612917870283127,
0.018994616344571114,
-0.010782918892800808,
-0.020813003182411194,
-0.01381742488592863,
-0.0020978047978132963,
-0.01185426115989685,
0.0042853704653680325,
-0.004603877663612366,
-0.008570740930736065,
-0.041000571101903915,
-0.00994900893419981,
-0.043525464832782745,
0.002626237226650119,
-0.0030837294179946184,
0.03134111687541008,
0.020465539768338203,
0.006700234953314066,
-0.006856592837721109,
-0.012566559948027134,
-0.020118078216910362,
-0.008674980141222477,
-0.014130140654742718,
-0.042575735598802567,
-0.03588129207491875,
-0.008431755937635899,
-0.009427815675735474,
-0.03141060844063759,
0.04449836164712906,
-0.039772871881723404,
0.0038944752886891365,
0.001656237873248756,
-0.03810505196452141,
-0.02317574806511402,
0.05587196722626686,
-0.019457899034023285,
-0.008976113982498646,
-0.03523269668221474,
0.04653680697083473,
-0.010997187346220016,
-0.014141722582280636,
-0.0041261170990765095,
0.019689541310071945,
-0.001077133696526289,
0.02571222372353077,
-0.031966548413038254,
0.012786619365215302,
0.030414549633860588,
0.06157035008072853,
0.01672452688217163,
-0.009613128378987312,
-0.0296501312404871,
-0.01701407879590988,
0.002029760042205453,
0.03175806999206543,
0.0237085223197937,
0.03310159221291542,
0.02253873273730278,
0.024276046082377434,
0.011141963303089142,
0.012126440182328224,
0.009723158553242683,
-0.019886435940861702,
0.042459916323423386,
0.023523209616541862,
0.03761860355734825,
-0.0035006843972951174,
-0.0012950216187164187,
-0.005591250490397215,
-0.020002257078886032,
-0.022793538868427277,
-0.007360413670539856,
0.04032881185412407,
-0.016157004982233047,
-0.04025932028889656,
0.06472067534923553,
-0.006161667872220278,
0.018114376813173294,
-0.014049066230654716,
0.041649170219898224,
0.03509370982646942,
0.03303210064768791,
0.013400469906628132,
0.022446075454354286,
0.019214674830436707,
0.0010923352092504501,
-0.04051412642002106,
0.0035585949663072824,
-0.02266613580286503,
0.026986252516508102,
-0.02670828253030777,
0.0004795706190634519,
0.021994374692440033,
-0.01755843684077263,
-0.01672452688217163,
0.011194082908332348,
0.015647392719984055,
0.008229069411754608,
0.0027536400593817234,
-0.04366445168852806,
0.0346304252743721,
0.017002496868371964,
-0.028144460171461105,
-0.005385668482631445,
0.030738847330212593,
0.006045847199857235,
0.008703934960067272,
0.02301359735429287,
-0.0005425481940619648,
0.0026117595843970776,
0.013307812623679638,
0.02594386599957943,
-0.0030605653300881386,
-0.010076411999762058,
-0.011136172339320183,
-0.017593182623386383,
0.020268645137548447,
0.018392346799373627,
-0.04032881185412407,
-0.01662028767168522,
0.008634442463517189,
0.04771818220615387,
0.025665896013379097,
-0.03377335146069527,
-0.020233897492289543,
0.018461840227246284,
-0.044591017067432404,
-0.05184140056371689,
-0.04496164619922638,
0.034769412130117416,
0.049802955240011215,
-0.010087993927299976,
-0.009966381825506687,
0.016006438061594963,
0.0035151620395481586,
-0.039703380316495895,
0.0016967750852927566,
0.0348852314054966,
0.019851690158247948,
0.021820643916726112,
-0.022272344678640366,
0.024113895371556282,
0.0010539694922044873,
0.000036782159440917894,
0.0015462080482393503,
-0.0038191918283700943,
-0.032429832965135574,
-0.017153063789010048,
-0.05021991208195686,
-0.012161186896264553,
-0.002197700086981058,
-0.013875334523618221,
-0.002759431255981326,
-0.0009620367200113833,
0.02317574806511402,
0.025967029854655266,
-0.002674013376235962,
0.01329623069614172,
-0.0012515888083726168,
0.007458860985934734,
0.0160296019166708,
-0.00681026466190815,
0.020975152030587196,
0.012010619975626469,
0.009115098975598812,
-0.025967029854655266,
-0.0027102073654532433,
0.0005139549029991031,
0.031897056847810745,
0.005958981346338987,
0.0237085223197937,
-0.027194730937480927,
-0.004479370545595884,
-0.022446075454354286,
0.04025932028889656,
-0.013678439892828465,
-0.007007159758359194,
0.01045282930135727,
-0.030020758509635925,
-0.006219578441232443,
0.0027579835150390863,
0.01895986869931221,
0.03212869539856911,
0.008999277837574482,
0.006624951492995024,
0.023036763072013855,
0.017986973747611046,
0.014164887368679047,
-0.019932763651013374,
0.005814205389469862,
0.004705220926553011,
-0.01708357222378254,
0.024345537647604942,
0.0034138187766075134,
0.022503986954689026,
-0.021450016647577286,
0.021148882806301117,
0.03562648594379425,
0.021693240851163864,
0.008622860535979271,
-0.02230709046125412,
-0.006607578136026859,
-0.004931071773171425,
-0.0221333596855402,
0.009920054115355015,
0.01942315325140953,
-0.0003349755425006151,
-0.013029842637479305,
-0.0011726858792826533,
-0.008188532665371895,
-0.02934899739921093,
0.007389368489384651,
-0.007661547511816025,
-0.007980055175721645,
-0.003497788915410638,
-0.02659246139228344,
0.008003219030797482,
0.013551036827266216,
-0.0326383076608181,
0.007592055015265942,
-0.02510995604097843,
-0.004467788152396679,
-0.0400276780128479,
0.00011518743121996522,
-0.011784768663346767,
0.007516771554946899,
0.0064975484274327755,
-0.0005617309943772852,
0.006949249655008316,
0.029140518978238106,
-0.022874612361192703,
-0.030321892350912094,
0.004346176516264677,
-0.0286540724337101,
-0.022318672388792038,
-0.02406756766140461,
0.04679161310195923,
-0.01919151097536087,
-0.04431304708123207,
0.00956680066883564,
0.00635277247056365,
-0.02207545004785061,
0.01696775108575821,
0.007864234037697315,
-0.036251917481422424,
0.02941848896443844,
0.010516530834138393,
0.024554016068577766,
-0.031132638454437256,
0.02119521051645279,
0.014778736978769302,
0.01045282930135727,
-0.019179929047822952,
0.0045488630421459675,
0.001034424756653607,
-0.005877906922250986,
-0.01685192994773388,
-0.010308053344488144,
0.02751902863383293,
-0.02747269906103611,
-0.008431755937635899,
0.00026638791314326227,
0.0071577271446585655,
0.027333714067935944,
0.015149364247918129,
0.02958063967525959,
-0.0064454288221895695,
-0.01452393177896738,
-0.021739568561315536,
-0.004114534705877304,
0.01613384112715721,
0.035834964364767075,
0.0151146175339818,
-0.021276285871863365,
-0.010464411228895187,
-0.022863030433654785,
-0.00842596497386694,
-0.01826494373381138,
0.05369453504681587,
-0.018473422154784203,
-0.007962681353092194,
0.03961072117090225,
0.0014151857467368245,
-0.014419692568480968,
-0.006428055930882692,
0.0019631630275398493,
0.009792651049792767,
0.016481302678585052,
-0.017975391820073128,
0.034491442143917084,
0.046096689999103546,
-0.0010373202385380864,
0.011721068061888218,
0.03268463537096977,
-0.06240426003932953,
-0.006277489010244608,
-0.024391865357756615,
0.009850561618804932,
0.001796670607291162,
-0.0025639834348112345,
-0.0033356398344039917,
-0.001174133620224893,
0.023812761530280113,
0.013435215689241886,
0.047625523060560226,
0.006196414120495319,
-0.0034775203093886375,
0.014419692568480968,
-0.002466983627527952,
-0.01743103377521038,
0.0122075155377388,
-0.024021239951252937,
-0.016585541889071465,
-0.04306218400597572,
-0.022978851571679115,
-0.038892634212970734,
0.010203815065324306,
-0.021577419713139534,
-0.010261725634336472,
-0.018948286771774292,
0.03458409756422043,
0.0201412420719862,
-0.012832948006689548,
-0.004412773530930281,
-0.017153063789010048,
-0.02059294283390045,
-0.03592761978507042,
0.0004567683790810406,
-0.03555699437856674,
-0.000020178160411887802,
0.007007159758359194,
-0.011894798837602139,
0.02494780533015728,
0.03646039590239525,
0.006949249655008316,
0.016990914940834045,
-0.0004976675845682621,
0.002403282094746828,
-0.028306609019637108,
-0.00714614475145936,
-0.07129929959774017,
-0.011084052734076977,
-0.021820643916726112,
-0.017755333334207535,
-0.0035209530033171177,
-0.027982311323285103,
-0.007725249044597149,
-0.0013406260404735804,
0.016759272664785385,
0.012659216299653053,
-0.0075283534824848175,
-0.007273547817021608,
-0.022642971947789192,
0.0015737154753878713,
0.016342317685484886,
-0.0018878794508054852,
-0.06027315929532051,
0.026013357564806938,
-0.022758793085813522,
0.0005686078802682459,
0.008049547672271729,
0.004606773145496845,
-0.034838903695344925,
0.010012710466980934,
0.0040074004791677,
0.02360428497195244,
-0.009068770334124565,
-0.003399341367185116,
-0.004042146727442741,
-0.010846620425581932,
0.03622875362634659,
0.00883712898939848,
0.01209169439971447,
0.012427574954926968,
-0.012508649379014969,
-0.015010379254817963,
0.0136205293238163,
0.014153304509818554,
0.026800939813256264,
0.02494780533015728,
-0.029395325109362602,
-0.010516530834138393,
-0.014130140654742718,
0.01584428921341896,
-0.02888571470975876,
-0.032244518399238586,
0.009381487034261227,
0.04331699013710022,
-0.04225143790245056,
0.002776804380118847,
-0.010835038498044014,
0.0386146642267704,
0.012786619365215302,
-0.0016822975594550371,
0.008605487644672394,
0.008877666667103767,
0.0028607745189219713,
-0.01867031678557396,
0.009410441853106022,
0.019515808671712875,
0.007852652110159397,
0.003295102622359991,
0.01825336180627346,
-0.03564964979887009,
0.03087783232331276,
-0.00022874612477608025,
0.013377305120229721,
-0.012983514927327633,
-0.04315483942627907,
0.012786619365215302,
0.001851685461588204,
-0.001515805022791028,
0.021507928147912025,
0.013400469906628132,
-0.014813483692705631,
-0.02828344516456127,
0.04354863241314888,
-0.009561008773744106,
-0.0357886366546154,
-0.0077599952928721905,
-0.023036763072013855,
0.006891339085996151,
-0.011709485203027725,
-0.010643933899700642,
-0.008547577075660229,
-0.024924641475081444,
-0.006607578136026859,
-0.022527150809764862,
-0.014199633151292801,
-0.028978370130062103,
-0.0037873410619795322,
-0.027565356343984604,
-0.01695616915822029,
0.01790590025484562,
-0.024693001061677933,
-0.07685869932174683,
0.019562138244509697,
0.02200595661997795,
-0.051146477460861206,
-0.027843326330184937,
-0.010782918892800808,
0.015994856134057045,
0.018346019089221954,
-0.048459433019161224,
-0.017176227644085884,
0.02594386599957943,
0.02460034377872944,
-0.007783159613609314,
0.0006894958787597716,
0.022990433499217033,
0.013041425496339798,
-0.018334437161684036,
-0.012751872651278973,
-0.02341897040605545,
-0.007302503101527691,
0.04785716533660889,
-0.022110195830464363,
0.011831097304821014,
0.01937682367861271,
-0.005709966644644737,
0.03317108377814293,
0.001612805062904954,
-0.023743269965052605,
0.03486206755042076,
-0.018172288313508034,
-0.012554978020489216,
-0.0306461900472641,
-0.009520472027361393,
-0.005660742986947298,
0.02448452264070511,
0.0002473860513418913,
-0.004994773305952549,
0.002397491130977869,
-0.002359849400818348,
0.023812761530280113,
-0.028746729716658592,
-0.020060166716575623,
0.005023728124797344,
0.027310550212860107,
0.02031497284770012,
-0.02224918082356453,
0.009323576465249062,
-0.015276767313480377,
-0.033078428357839584,
-0.010192233137786388,
-0.009520472027361393,
-0.006202205084264278,
-0.023141000419855118,
0.006694443989545107,
0.012068530544638634,
0.011738440953195095,
0.015288349241018295,
-0.018797719851136208,
-0.012068530544638634,
-0.012323335744440556,
-0.01590219885110855,
-0.012809783220291138,
-0.01136202272027731,
-0.01590219885110855,
-0.0021716405171900988,
-0.01936524175107479,
-0.005921339616179466,
-0.020558197051286697,
0.02018756978213787,
0.006514921318739653,
0.003410923294723034,
-0.014639751985669136,
0.010846620425581932,
-0.013886917382478714,
0.013829006813466549,
-0.028491923585534096,
-0.006833428516983986,
-0.03567281365394592,
-0.01871664635837078,
-0.03194338455796242,
-0.017535272985696793,
0.018762974068522453,
-0.004812355153262615,
-0.05059053748846054,
0.0023511627223342657,
0.014245961792767048,
-0.01065551582723856,
0.013493126258254051,
0.027773834764957428,
0.004366445355117321,
0.006161667872220278,
-0.04943232983350754,
-0.007088234648108482,
-0.016828766092658043,
0.023511627689003944,
-0.012485485523939133,
0.012439156882464886,
-0.011721068061888218,
-0.014037484303116798,
-0.026847267523407936,
-0.03773442655801773,
-0.021090973168611526,
-0.0018907749326899648,
-0.0000922494800761342,
-0.008570740930736065,
-0.0009439397254027426,
0.00006867812771815807,
-0.01470924448221922,
-0.004328803159296513,
-0.021693240851163864,
0.015450498089194298,
0.008171158842742443,
0.01636548340320587,
0.03145693615078926,
0.048691075295209885,
-0.012763455510139465,
-0.0037149530835449696,
0.00804375670850277,
0.018461840227246284,
-0.00012450739450287074,
0.004056624602526426,
0.05503805726766586,
-0.010348591022193432,
-0.015496826730668545,
0.02106780745089054,
-0.00014812397421337664,
-0.027426371350884438,
-0.0006124026258476079,
-0.0030374012421816587,
-0.010302262380719185,
0.010163277387619019,
-0.030623026192188263,
0.02448452264070511,
-0.014153304509818554,
0.003677311120554805,
0.019874854013323784,
0.013076171278953552,
-0.039888691157102585,
0.02266613580286503,
0.006410682573914528,
-0.013099335134029388,
0.007383577525615692,
-0.013539454899728298,
-0.013678439892828465,
0.011582083068788052,
0.014257543720304966,
-0.010725008323788643,
0.020048584789037704,
0.009178800508379936,
-0.003292206907644868,
0.018403928726911545,
-0.015381005592644215,
0.02343055233359337,
0.030900996178388596,
-0.008200114592909813,
0.011460470966994762,
0.02295568771660328,
0.004679161589592695,
0.011002978309988976,
0.0442667193710804,
0.014384946785867214,
-0.023974910378456116,
0.0024076253175735474,
-0.02529526874423027,
0.008072711527347565,
-0.03564964979887009,
0.0037525948137044907,
0.10748172551393509,
-0.024090731516480446,
-0.004192714113742113,
0.008298561908304691,
-0.005825787782669067,
0.0031792817171663046,
0.00441856449469924,
-0.005733130965381861,
0.006549667567014694,
-0.019886435940861702,
0.008026382885873318,
-0.00003617138645495288,
0.017164645716547966,
-0.008200114592909813,
0.03574230521917343,
-0.018056467175483704,
0.0021788792219012976,
0.02448452264070511,
0.018334437161684036,
0.006653906311839819,
0.024137061089277267,
0.014188051223754883,
-0.012033783830702305,
0.0258280448615551,
-0.015242020599544048,
-0.015079871751368046,
-0.01779007911682129,
-0.011286739259958267,
0.021785898134112358,
0.01450076699256897,
0.012983514927327633,
0.013643693178892136,
0.00701295118778944,
-0.014859812334179878,
0.00780632346868515,
-0.0288162212818861,
-0.006816055625677109,
-0.004962922539561987,
0.03708582744002342,
-0.008640233427286148,
-0.007829488255083561,
0.006821846589446068,
0.026499805971980095,
0.012937186285853386,
0.02095198817551136,
0.010232769884169102,
-0.03245299682021141,
-0.0025046253576874733,
0.010111157782375813,
-0.022260762751102448,
-0.002073192736133933,
0.0012096037389710546,
0.015369423665106297,
0.0029418489430099726,
-0.025341596454381943,
-0.027495864778757095,
0.012311753816902637,
-0.013435215689241886,
-0.01854291372001171,
-0.018913540989160538,
-0.007030324079096317,
0.007603637408465147,
0.0071577271446585655,
0.009810023941099644,
0.01708357222378254
] | 2024-07-17 | 1 | 39013470 | [
"CAR)-T cells",
"complete B cell depletion",
"immune rejection",
"promising immune modulatory effect",
"severe refractory autoimmune diseases",
"other serious adverse events",
"cytokine release syndrome",
"allograft rejection",
"diffuse cutaneous systemic sclerosis",
"Allogeneic chimeric antigen receptor",
"deep remission",
"great promise",
"CAR-T therapy",
"The infused cells",
"the clinical response index scores",
"reversal",
"these cells",
"healthy-donor-derived, CD19-targeting CAR-T cells",
"inflammation",
"fibrosis",
"Allogeneic",
"treatment",
"one patient",
"two patients",
"the high safety",
"the significant improvement",
"CRISPR-Cas9",
"all three patients",
"the observations",
"(NCT05859997"
] | [
"CD19",
"allogeneic CAR-T cells",
"autoimmune diseases",
"myositis",
"systemic sclerosis"
] | 0 | 10.1016/j.cell.2024.06.027 | [
"Wang",
"Wu",
"Tan",
"Zhu",
"Zhang",
"Lin",
"Xiao",
"Sun",
"Wan",
"Liu",
"Liu",
"Ta",
"Zhang",
"Song",
"Li",
"Zhou",
"Yin",
"Ye",
"Lu",
"Hong",
"Cheng",
"Wang",
"Li",
"Chen",
"Zhang",
"Luo",
"Huang",
"Guo",
"Pan",
"Jin",
"Ye",
"Dai",
"Zhu",
"Sun",
"Zheng",
"Li",
"He",
"Liu",
"Wu",
"Du",
"Xu"
] | [
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China; National Key Laboratory for Immunity and Inflammation, Shanghai, China.",
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China; National Key Laboratory for Immunity and Inflammation, Shanghai, China.",
"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China; BRL Medicine Inc., Shanghai 201109, China.",
"Department of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.",
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China; National Key Laboratory for Immunity and Inflammation, Shanghai, China.",
"Department of Radiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Radiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Radiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Radiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"National Key Laboratory for Immunity and Inflammation, Shanghai, China; Department of Pathology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200082, China.",
"Department of Pathology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200082, China.",
"Department of Ultrasound, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Ultrasound, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Rheumatology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China.",
"Department of Rheumatology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China.",
"Department of Rheumatology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China.",
"Department of Pathology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China.",
"Department of Rheumatology and Clinical Immunology, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315040, China.",
"School of Medicine, Tsinghua University, Beijing 100084, China.",
"School of Medicine, Tsinghua University, Beijing 100084, China.",
"Department of Medical Ultrasound, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.",
"Department of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China.",
"Department of Dermatology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai Key Laboratory of Medical Mycology, Shanghai 200082, China.",
"Department of Rheumatology and Immunology, Shanghai Huashan Hospital, Fudan University, Shanghai 200040, China.",
"Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.",
"Department of Rheumatology and Immunology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.",
"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.",
"BRL Medicine Inc., Shanghai 201109, China.",
"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China; BRL Medicine Inc., Shanghai 201109, China.",
"Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637, USA.",
"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China; BRL Medicine Inc., Shanghai 201109, China. Electronic address: [email protected].",
"Department of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: [email protected].",
"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China; BRL Medicine Inc., Shanghai 201109, China. Electronic address: [email protected].",
"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, China; National Key Laboratory for Immunity and Inflammation, Shanghai, China; School of Medicine, Tsinghua University, Beijing 100084, China; Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: [email protected]."
] | [
"39013470"
] | [] | 8.112821 | 3.370669 |
39012598 | 722 | Protocol for Efficient Generation of Chimeric Antigen Receptor T Cells with Multiplexed Gene Silencing by Epigenome Editing. | Multiplex gene regulation enables the controlled and simultaneous alteration of the expression levels of multiple genes and is generally pursued to precisely alter complex cellular pathways with a single intervention. Thus far, this has been typically exploited in combination with genome editing tools (i.e., base-/prime-editing, designer nucleases) to enable simultaneous genetic alterations and modulate complex physiologic cellular pathways. In the field of cancer immunotherapy, multiplex genome editing has been used to simultaneously inactivate three genes (i.e., TRAC, B2M, and PDCD1) and generate universal chimeric antigen receptor (CAR) T cells resistant to the inhibitory activity of the PD-1 ligand. However, the intrinsic risk of genomic aberrations driven by such tools poses concerns because of the generation of multiple single-strand or double-strand DNA breaks followed by DNA repair. Modulating gene expression without DNA damage using epigenome editing promises a safer and efficient approach to alter gene expression. This method enables for simultaneous activation and/or repression of target genes, offering superior fine-tuning capabilities with reduced off-targeting effects and potential reversibility as compared to genome editing. Here we describe a detailed protocol for achieving multiplexed and sustainable gene silencing in CAR T cells. In an exemplary approach, we use designer epigenome modifiers (DEMs) for the simultaneous inactivation of two T cell inhibitory genes, PDCD1 and LAG3 to generate CAR T cells with increased resistance to tumor-induced exhaustion. | [
0.01596803218126297,
0.035222169011831284,
0.03269065171480179,
0.040358226746320724,
-0.04391208663582802,
0.012925342656672001,
0.03271499276161194,
0.014373662881553173,
-0.0037151232827454805,
-0.003672525752335787,
0.03663397580385208,
-0.03738856315612793,
0.0027551548555493355,
-0.00031548881088383496,
0.00675476947799325,
-0.04834224283695221,
0.03785105049610138,
0.01633315533399582,
0.027773665264248848,
0.0011014534393325448,
-0.005400773137807846,
0.03765631839632988,
-0.005911944899708033,
0.030962403863668442,
-0.025388197973370552,
-0.028138788416981697,
0.022722801193594933,
0.017964035272598267,
0.008890737779438496,
0.004439283162355423,
0.04215949773788452,
-0.011136242188513279,
-0.018256133422255516,
-0.02770064026117325,
-0.03144923225045204,
0.02594805136322975,
0.02328265644609928,
0.039311543107032776,
-0.028114447370171547,
-0.006204043049365282,
0.045348238199949265,
-0.04729555919766426,
-0.04186740145087242,
0.039116811007261276,
-0.029696645215153694,
0.009992190636694431,
-0.034443240612745285,
-0.03777802735567093,
0.035124801099300385,
0.01904723420739174,
-0.009091555140912533,
-0.0042293379083275795,
-0.04953497648239136,
0.05866304412484169,
-0.0519447885453701,
0.027554592117667198,
-0.03875168785452843,
0.008330882526934147,
-0.017051229253411293,
0.039847053587436676,
0.0050630345940589905,
-0.00834913831204176,
0.015931520611047745,
-0.005230382550507784,
-0.04731990024447441,
0.03242289274930954,
-0.04929156228899956,
-0.01599237322807312,
0.0038855138700455427,
0.03169265016913414,
-0.012414171360433102,
-0.01321744080632925,
-0.01921762339770794,
-0.0006092984694987535,
0.04286540299654007,
-0.025217806920409203,
-0.025436880066990852,
0.03748592734336853,
0.00900027435272932,
-0.023039240390062332,
0.06747467070817947,
0.006608720403164625,
0.009627068415284157,
-0.007886650040745735,
-0.03230118751525879,
-0.02188302017748356,
0.039798371493816376,
-0.00006128165841801092,
-0.06737730652093887,
-0.025193465873599052,
-0.034613631665706635,
-0.003833788214251399,
-0.03809446841478348,
0.06737730652093887,
0.0026532248593866825,
0.04318184405565262,
0.010126069188117981,
-0.030670305714011192,
0.0028433927800506353,
0.04668702185153961,
0.055742062628269196,
0.0019077659817412496,
-0.015286469832062721,
0.010545959696173668,
0.009048957377672195,
-0.014811810106039047,
-0.030913719907402992,
0.007746686227619648,
0.02628883346915245,
0.002414373680949211,
0.07093116641044617,
-0.015505542978644371,
-0.021724799647927284,
0.0543789379298687,
0.029745327308773994,
-0.07146667689085007,
-0.023952048271894455,
0.02447539009153843,
0.0022546325344592333,
0.02117711491882801,
-0.06275241822004318,
0.016223618760704994,
0.03665831685066223,
-0.015980202704668045,
0.014446687884628773,
-0.060513000935316086,
0.04639492183923721,
-0.014750956557691097,
-0.021384017542004585,
-0.03115713596343994,
0.020337333902716637,
-0.000566700822673738,
0.04142925515770912,
0.002132924972102046,
-0.055693380534648895,
-0.022686289623379707,
0.01865777000784874,
0.029331522062420845,
-0.030840696766972542,
0.0011585038155317307,
0.01645486243069172,
-0.030037425458431244,
0.01941235549747944,
0.03154660016298294,
-0.04990009963512421,
-0.024560585618019104,
-0.030840696766972542,
0.022978387773036957,
-0.045031797140836716,
0.08242035657167435,
-0.039920080453157425,
0.0034990923013538122,
0.020252138376235962,
0.006395732518285513,
0.02711644396185875,
-0.04951063543558121,
-0.04924288019537926,
0.050484295934438705,
-0.02469446323812008,
-0.04727121815085411,
-0.02609410136938095,
0.03517348691821098,
-0.011057131923735142,
-0.012523707933723927,
0.034443240612745285,
-0.004363215994089842,
-0.006852135527879,
0.028820350766181946,
-0.06333661824464798,
-0.016199275851249695,
-0.04259764775633812,
-0.0537947416305542,
-0.04868302494287491,
0.0010763512691482902,
-0.03276367485523224,
-0.04403379559516907,
-0.0535513274371624,
0.009797458536922932,
-0.08383216708898544,
-0.02338002249598503,
0.003413897007703781,
0.010789374820888042,
0.02127448096871376,
0.03575768321752548,
-0.007825796492397785,
-0.011817804537713528,
-0.008708176203072071,
0.02570463716983795,
-0.039847053587436676,
-0.021335335448384285,
0.024877024814486504,
0.00580240786075592,
0.03273933380842209,
0.0260697603225708,
0.01804923079907894,
-0.04235422983765602,
0.0532105453312397,
0.030159134417772293,
-0.021676115691661835,
-0.07492317259311676,
0.014446687884628773,
-0.02621580846607685,
-0.006012353580445051,
-0.010643325746059418,
-0.02296621724963188,
-0.006748684216290712,
-0.04181871935725212,
0.006185786798596382,
-0.010314716026186943,
0.044812723994255066,
0.04452062398195267,
0.03322616592049599,
-0.014604907482862473,
0.01179954782128334,
-0.02146921306848526,
-0.04405813664197922,
-0.012243780307471752,
-0.01579764112830162,
0.0025680295657366514,
0.025655953213572502,
-0.01865777000784874,
-0.03322616592049599,
-0.000640105688944459,
0.0014840716030448675,
-0.007539783604443073,
-0.014069394208490849,
0.017891012132167816,
-0.023440876975655556,
0.024779658764600754,
0.01958274655044079,
0.01829264685511589,
0.016686106100678444,
0.01882815919816494,
-0.0533079132437706,
0.007083380129188299,
0.014118077233433723,
-0.0022378978319466114,
-0.02325831539928913,
0.04668702185153961,
-0.03819183260202408,
-0.014641419984400272,
-0.001696299179457128,
-0.01856040395796299,
-0.027724983170628548,
-0.03595241531729698,
0.02372080273926258,
-0.006237512454390526,
-0.06508920341730118,
-0.023562584072351456,
0.011093644425272942,
0.028017081320285797,
0.028674300760030746,
0.00597888370975852,
-0.024913538247346878,
0.017611084505915642,
0.030718987807631493,
0.06338530033826828,
0.010405996814370155,
0.015834154561161995,
0.007953588850796223,
-0.013302636332809925,
0.003030518302693963,
-0.06942199170589447,
-0.006280110217630863,
-0.02667829766869545,
0.035076119005680084,
0.023270485922694206,
0.007387648802250624,
-0.0025102184154093266,
-0.017306815832853317,
0.028625618666410446,
0.008373480290174484,
-0.005202998407185078,
-0.00527602294459939,
-0.034029435366392136,
0.009018530137836933,
0.00659654987975955,
0.03656095266342163,
-0.02672697976231575,
-0.004868302494287491,
-0.05866304412484169,
-0.02479182928800583,
0.030743330717086792,
-0.004019392188638449,
-0.0019062446663156152,
0.0012338104424998164,
-0.004728338681161404,
0.03809446841478348,
-0.005872389767318964,
-0.04802580177783966,
0.01166566926985979,
-0.002414373680949211,
-0.0018606043886393309,
-0.02081199362874031,
0.007095550652593374,
-0.0038946419954299927,
-0.01851172000169754,
-0.02757893316447735,
-0.04376604035496712,
0.0263131745159626,
0.010272118262946606,
-0.00451839342713356,
-0.029380206018686295,
-0.06937330961227417,
-0.003477793652564287,
0.029307181015610695,
-0.029501913115382195,
-0.055693380534648895,
0.022162945941090584,
0.0013091169530525804,
0.007150319404900074,
-0.030183475464582443,
0.0011585038155317307,
-0.0031796100083738565,
0.018815988674759865,
0.020702455192804337,
0.0129618551582098,
-0.04430155083537102,
0.010168666951358318,
-0.04800146073102951,
-0.006243597716093063,
0.016661765053868294,
-0.03697475790977478,
-0.02692171186208725,
-0.0026562674902379513,
-0.022418532520532608,
-0.012103816494345665,
-0.02633751556277275,
0.028869032859802246,
-0.024925708770751953,
0.025096099823713303,
-0.017452863976359367,
0.03899510204792023,
0.03283670172095299,
0.02425631694495678,
-0.0270921029150486,
-0.04853697493672371,
-0.020970212295651436,
0.00948710460215807,
0.011732609011232853,
-0.03344523906707764,
0.03237421065568924,
-0.03811880946159363,
-0.009687921963632107,
-0.001982311950996518,
-0.01618710532784462,
-0.012310720048844814,
0.050971128046512604,
0.04067466780543327,
-0.017160765826702118,
0.034613631665706635,
0.027798006311058998,
0.0133513193577528,
0.02386685274541378,
0.056326258927583694,
0.04118583723902702,
0.02381816878914833,
0.014057223685085773,
-0.0016491374699398875,
-0.03273933380842209,
0.025120440870523453,
0.0037729344330728054,
-0.027627617120742798,
0.0532105453312397,
0.007856222800910473,
0.04065032675862312,
-0.03298274800181389,
0.03777802735567093,
-0.03320182114839554,
-0.0031081067863851786,
-0.010509448125958443,
0.03838656470179558,
0.029550595209002495,
0.02628883346915245,
-0.015176933258771896,
0.05992880463600159,
0.00009456106636207551,
0.044958774000406265,
0.03288538381457329,
-0.022479387000203133,
0.06830228120088577,
0.017696280032396317,
-0.021408360451459885,
-0.03359128534793854,
-0.030329523608088493,
-0.0023580840788781643,
0.06396949291229248,
-0.0272381529211998,
-0.06411554664373398,
0.002733855973929167,
-0.01215249951928854,
-0.012657586485147476,
0.029307181015610695,
-0.015091737732291222,
0.004828747361898422,
0.019327159970998764,
0.0029955273494124413,
0.04361999034881592,
0.04895078018307686,
-0.021992556750774384,
0.008148320950567722,
-0.06309320032596588,
-0.013655588030815125,
-0.02479182928800583,
0.0027505909092724323,
-0.04103979095816612,
0.06494315713644028,
0.012255951762199402,
0.051117174327373505,
0.011787377297878265,
0.007284197490662336,
0.01909591630101204,
0.030353866517543793,
0.039944421499967575,
0.02078765071928501,
-0.029574938118457794,
-0.034297190606594086,
0.028698643669486046,
0.018523890525102615,
0.013899003155529499,
-0.0023002729285508394,
-0.03376167640089989,
0.04408247768878937,
-0.02066594362258911,
0.02692171186208725,
0.015444689430296421,
-0.01587066613137722,
-0.012584561482071877,
0.022613264620304108,
-0.03853261470794678,
-0.02711644396185875,
0.04800146073102951,
0.03196040540933609,
-0.04091808199882507,
0.0063835615292191505,
0.050873760133981705,
0.006048865616321564,
0.029112448915839195,
-0.022783655673265457,
0.0272138100117445,
-0.07331663370132446,
0.055839430540800095,
0.016101909801363945,
-0.02342870458960533,
0.003946367651224136,
-0.00786230806261301,
-0.01890118420124054,
0.03239855170249939,
0.008732517249882221,
-0.022722801193594933,
-0.03845958784222603,
-0.0012079474981874228,
-0.002922502811998129,
0.018986379727721214,
-0.029794011265039444,
-0.029745327308773994,
0.031011085957288742,
-0.0547197200357914,
0.023100094869732857,
0.0260697603225708,
0.04218383878469467,
-0.030889378860592842,
0.007387648802250624,
-0.04191608354449272,
-0.020154772326350212,
0.0527237169444561,
0.006426159292459488,
-0.017598913982510567,
-0.011714352294802666,
-0.00038471000152640045,
0.010253861546516418,
-0.011203180998563766,
-0.03880036994814873,
0.030402548611164093,
-0.019972210749983788,
-0.010332971811294556,
-0.007466759067028761,
0.0033226164523512125,
0.023440876975655556,
0.015907177701592445,
-0.016686106100678444,
-0.027895372360944748,
0.0018240921199321747,
0.01904723420739174,
0.025266489014029503,
0.051263224333524704,
-0.011982109397649765,
-0.003158311126753688,
0.014495370909571648,
0.01041816733777523,
-0.004408856388181448,
-0.014763127081096172,
0.02154223807156086,
-0.011203180998563766,
-0.0018621257040649652,
0.005011308938264847,
0.0037607636768370867,
-0.011008448898792267,
0.01232289057224989,
-0.0016537015326321125,
0.016905181109905243,
0.03303143382072449,
-0.03670699894428253,
0.004494051914662123,
0.0526263490319252,
0.06562471389770508,
0.018815988674759865,
0.003806404070928693,
0.008549956604838371,
0.024974390864372253,
-0.0276032742112875,
-0.03821617364883423,
0.0004811252001672983,
-0.03222816064953804,
-0.028382202610373497,
0.005087376106530428,
-0.012085560709238052,
-0.021846506744623184,
-0.014945688657462597,
-0.005266894586384296,
-0.0007538262289017439,
-0.005087376106530428,
-0.02680000476539135,
0.040504276752471924,
0.0071868314407765865,
-0.029769670218229294,
-0.029964402318000793,
-0.03371299430727959,
-0.01640617847442627,
-0.040455594658851624,
0.014982201159000397,
-0.0009310628520324826,
0.0022683246061205864,
0.03733988106250763,
-0.03629319369792938,
-0.03332353010773659,
0.0014361492358148098,
0.01574895903468132,
-0.015432518906891346,
-0.03853261470794678,
-0.014069394208490849,
-0.023075753822922707,
0.019740967079997063,
-0.0008146800100803375,
-0.016807815060019493,
0.019254136830568314,
0.008908993564546108,
-0.03850827366113663,
0.03093806281685829,
-0.025290831923484802,
0.00954795815050602,
-0.01601671427488327,
0.035465583205223083,
-0.01601671427488327,
-0.024463219568133354,
0.0012566305231302977,
0.0009926772909238935,
0.005674615036696196,
0.0006701522506773472,
-0.0258020032197237,
-0.017538059502840042,
-0.0006092984694987535,
0.024098096415400505,
-0.030913719907402992,
-0.018621256574988365,
0.021919531747698784,
-0.0021222755312919617,
0.006024524103850126,
-0.0269703958183527,
0.0015456860419362783,
-0.023489559069275856,
-0.01067375298589468,
0.00661480613052845,
-0.008257858455181122,
0.0522855669260025,
0.022795826196670532,
-0.0514092743396759,
-0.011884743347764015,
-0.01821962185204029,
-0.02093370072543621,
-0.0028327435720711946,
-0.02641054056584835,
0.044885747134685516,
-0.004783106967806816,
-0.0536973774433136,
0.0071868314407765865,
-0.02648356556892395,
0.00016763314488343894,
-0.040431249886751175,
0.024268487468361855,
0.008714261464774609,
0.007844052277505398,
0.060707733035087585,
0.016953863203525543,
0.00589977391064167,
0.015079567208886147,
0.029404547065496445,
0.010862399823963642,
-0.020215624943375587,
-0.017026888206601143,
0.01584632508456707,
0.002463056705892086,
-0.019132427871227264,
-0.028284836560487747,
-0.004865259863436222,
0.01053987443447113,
-0.013886832632124424,
0.019375843927264214,
0.006961672566831112,
-0.015469031408429146,
0.012414171360433102,
0.0053916447795927525,
-0.015566397458314896,
0.018523890525102615,
-0.004923070780932903,
0.015164761804044247,
0.0010094121098518372,
-0.01875513605773449,
0.025169122964143753,
-0.040285203605890274,
0.017039058730006218,
0.022807996720075607,
-0.0031035428401082754,
-0.0019442782504484057,
0.005321662873029709,
-0.04133188724517822,
-0.02675132267177105,
-0.02577766217291355,
0.02687302976846695,
0.023075753822922707,
-0.008172662928700447,
-0.04756331443786621,
-0.022613264620304108,
0.03804578259587288,
-0.00522125419229269,
-0.009937422350049019,
0.0266539566218853,
-0.014057223685085773,
-0.011519620195031166,
-0.029428888112306595,
0.012621073983609676,
-0.0015137378359213471,
0.020386015996336937,
-0.017404181882739067,
0.004058947321027517,
-0.012499366886913776,
-0.018037060275673866,
-0.022491557523608208,
0.024146780371665955,
-0.02054423652589321,
0.0008511922787874937,
-0.027627617120742798,
0.03269065171480179,
0.019862674176692963,
0.018815988674759865,
-0.019996551796793938,
0.018986379727721214,
-0.006222298834472895,
0.023830341175198555,
0.039481934159994125,
-0.03368865326046944,
0.021213628351688385,
-0.012195097282528877,
-0.0272868350148201,
-0.00656003737822175,
0.025266489014029503,
-0.017623255029320717,
-0.002391553483903408,
-0.050630345940589905,
0.007363307289779186,
0.07784415781497955,
0.00475572282448411,
0.013667759485542774,
0.010205178521573544,
-0.010874570347368717,
0.009176749736070633,
0.008982017636299133,
-0.008336967788636684,
-0.027554592117667198,
-0.008148320950567722,
-0.008537785150110722,
-0.0004453736182767898,
-0.044569309800863266,
0.01608973927795887,
-0.0029072894249111414,
0.009055042639374733,
-0.003660354996100068,
0.010387740097939968,
0.017209449782967567,
-0.03342089802026749,
0.018694281578063965,
-0.018840329721570015,
-0.021457042545080185,
-0.001160785905085504,
0.011976024135947227,
0.009420164860785007,
0.007387648802250624,
0.0037242514081299305,
-0.007941418327391148,
-0.024609269574284554,
0.0544763058423996,
0.04783106967806816,
-0.021237969398498535,
0.008245687000453472,
0.03624451160430908,
-0.01626013033092022,
-0.023367851972579956,
-0.015201274305582047,
0.01868211105465889,
0.012024707160890102,
0.029842693358659744,
-0.004451454151421785,
-0.03583070635795593,
-0.03663397580385208,
-0.004436240531504154,
-0.034832704812288284,
-0.029161131009459496,
-0.002548251999542117,
0.03349392116069794,
0.0034838789142668247,
-0.02059291861951351,
0.0130348801612854,
-0.017282472923398018,
-0.0018803818384185433,
0.02056857757270336,
-0.006097548641264439,
-0.04909683018922806,
0.04943761229515076,
-0.04094242304563522,
0.015882836654782295,
-0.011829975061118603,
-0.02051989547908306,
0.006912989541888237,
-0.0034595374017953873,
-0.0005339919007383287,
0.024000730365514755,
-0.0026562674902379513,
-0.035124801099300385,
-0.0132296122610569,
-0.009760946035385132,
0.029088107869029045,
0.007345051504671574,
-0.002137489151209593,
0.005403815768659115,
-0.017270302399992943,
0.04274369403719902,
0.0514092743396759,
0.0046522715128958225,
0.0011904521379619837,
-0.015262127853929996,
-0.007673661690205336,
0.00964532420039177,
-0.03115713596343994,
0.01577330008149147,
-0.0135460514575243,
-0.012122073210775852,
-0.0026212765369564295,
0.0263861995190382,
-0.00780145451426506,
-0.02428065799176693,
-0.029331522062420845,
0.011623072437942028,
0.017489377409219742,
0.02435368299484253,
-0.012006450444459915,
0.01860908605158329,
-0.008562127128243446,
0.027019077911973,
-0.010582472197711468,
0.0516040064394474,
-0.03174133226275444,
0.005279065575450659,
-0.010856314562261105,
-0.004999137949198484,
0.002507175784558058,
0.020252138376235962,
-0.002641054103150964,
0.008951591327786446,
-0.0267026387155056,
-0.008866395801305771,
-0.00892724934965372,
0.00786230806261301,
-0.035222169011831284,
-0.0014544053701683879,
-0.01640617847442627,
-0.0028175299521535635,
-0.01948538050055504,
0.008738602511584759,
0.009395823813974857,
-0.013667759485542774,
-0.012122073210775852,
0.007466759067028761,
-0.028966398909687996,
0.016004543751478195,
-0.029526254162192345,
0.024171121418476105,
0.03247157856822014,
-0.09512662887573242,
-0.007381563540548086,
0.015371665358543396,
-0.006143189035356045,
-0.025753319263458252,
0.004947412293404341,
0.014994371682405472,
0.029088107869029045,
-0.01804923079907894,
-0.023952048271894455,
-0.014361492358148098,
-0.019935699179768562,
0.022235970944166183,
0.008099637925624847,
0.009736604988574982,
-0.02621580846607685,
-0.03166830912232399,
-0.051506638526916504,
0.020799821242690086,
0.01196993887424469,
-0.008537785150110722,
-0.012292463332414627,
-0.009870483539998531,
0.007551954127848148,
0.015566397458314896,
0.030816353857517242,
0.003909855615347624,
0.01244459766894579,
-0.0272138100117445,
0.02359909564256668,
-0.007624978665262461,
0.020288649946451187,
-0.019826160743832588,
0.01364341750741005,
-0.04067466780543327,
-0.02440236508846283,
0.02367212064564228,
-0.03724251314997673,
0.014641419984400272,
0.017148595303297043,
-0.0008839011425152421,
0.015882836654782295,
-0.0002228769735665992,
-0.011057131923735142,
-0.04722253233194351,
-0.016369666904211044,
-0.03320182114839554,
0.011014534160494804,
0.01834132894873619,
-0.015176933258771896,
-0.0022515899036079645,
-0.03213079646229744,
-0.011324888095259666,
-0.014446687884628773,
0.0060549513436853886,
-0.006057993974536657,
-0.012499366886913776,
0.06338530033826828,
0.01380163710564375,
0.025363855063915253,
-0.008014443330466747,
0.03174133226275444,
0.035027436912059784,
-0.006255768705159426,
-0.019838333129882812,
0.0033986836206167936,
-0.02120145782828331,
0.018475208431482315,
-0.028017081320285797,
-0.005519438069313765,
-0.015712445601820946,
0.023879023268818855,
-0.04288974404335022,
0.015249957330524921,
-0.011111900210380554,
-0.022491557523608208,
-0.0032009088899940252,
0.008221345953643322,
-0.01038165483623743,
0.035076119005680084,
-0.022162945941090584,
-0.005291236098855734,
-0.007497185841202736,
0.0039037701208144426,
-0.02731117606163025,
0.014422345906496048,
-0.014373662881553173,
0.009931337088346481,
0.02129882387816906,
0.007643234916031361,
0.024049414321780205,
-0.02435368299484253,
-0.008330882526934147,
0.006523525342345238,
0.01077111903578043,
-0.0274815671145916,
-0.029039423912763596,
0.013314806856215,
-0.0024569714441895485,
0.003940282389521599,
0.039384566247463226,
-0.029647961258888245,
-0.011422254145145416,
-0.04086939990520477,
-0.04091808199882507,
-0.010132154449820518,
0.03157094120979309,
-0.017513718456029892,
-0.004828747361898422,
-0.024268487468361855,
0.03748592734336853,
0.009925251826643944,
-0.007746686227619648,
0.005406858399510384,
0.011057131923735142,
-0.019667942076921463,
0.04904814809560776,
-0.0543302558362484,
0.034759677946567535,
0.030499914661049843,
0.056520991027355194,
0.014203272759914398,
-0.03678002581000328,
-0.02660527266561985,
-0.008586468175053596,
-0.0042597646825015545,
0.01630881242454052,
0.056034162640571594,
0.013558221980929375,
-0.004460582043975592,
0.005254724062979221,
0.01834132894873619,
0.022990558296442032,
0.005793279968202114,
-0.033810362219810486,
0.02616712637245655,
0.01950972154736519,
0.0540868416428566,
-0.02428065799176693,
0.02694605477154255,
-0.002466099336743355,
-0.015249957330524921,
0.022187288850545883,
-0.028771666809916496,
0.0259967353194952,
-0.007612808141857386,
-0.016223618760704994,
0.02570463716983795,
-0.051263224333524704,
-0.00609450601041317,
-0.02188302017748356,
0.0036786110140383244,
0.009152408689260483,
0.050094831734895706,
0.029477572068572044,
0.03617148846387863,
0.01877947710454464,
0.002922502811998129,
-0.0258750282227993,
-0.00002272508390888106,
-0.03704778105020523,
0.03772934526205063,
-0.028090104460716248,
-0.0024478433188050985,
-0.002285059541463852,
0.010838057845830917,
0.013570393435657024,
-0.01352171041071415,
0.02672697976231575,
-0.0002124177262885496,
0.019972210749983788,
-0.08607158809900284,
0.0517500564455986,
-0.03132752701640129,
-0.01674696058034897,
0.015456859953701496,
0.01912025734782219,
-0.015931520611047745,
0.021530067548155785,
0.018377842381596565,
-0.013911174610257149,
0.004877430386841297,
0.017160765826702118,
0.046273212879896164,
0.01868211105465889,
-0.007059038616716862,
-0.010174752213060856,
-0.022661948576569557,
0.004722253419458866,
0.004554905463010073,
0.016540057957172394,
0.0030487743206322193,
0.024584926664829254,
0.044764041900634766,
0.008233516477048397,
0.00968183670192957,
-0.0258750282227993,
0.0064991838298738,
-0.03125450015068054,
-0.011556132696568966,
-0.07842835038900375,
0.024171121418476105,
0.01919328235089779,
-0.011397913098335266,
-0.039092469960451126,
0.028455227613449097,
0.01800054870545864,
-0.021676115691661835,
-0.02168828807771206,
0.03860563784837723,
0.0026471393648535013,
0.025558587163686752,
-0.01232289057224989,
0.039847053587436676,
0.014093735255300999,
-0.029940059408545494,
0.0019229794852435589,
-0.005790237337350845,
-0.034930068999528885,
-0.01890118420124054,
-0.04814751073718071,
-0.023879023268818855,
0.017209449782967567,
0.008671663701534271,
-0.018256133422255516,
-0.013947686180472374,
-0.016467032954096794,
-0.0016658722888678312,
-0.0053307912312448025,
0.034078117460012436,
-0.02132316492497921,
0.01933933049440384,
0.04318184405565262,
-0.005875432398170233,
0.01561508048325777,
-0.01640617847442627,
-0.018061401322484016,
-0.03320182114839554,
-0.00553160859271884,
-0.0015068916836753488,
0.034467581659555435,
0.018450865522027016,
-0.011203180998563766,
-0.0016324026510119438,
0.008915078826248646,
-0.005851090885698795,
0.03892207890748978,
-0.00805704016238451,
0.007491100579500198,
-0.01672261953353882,
-0.01102670468389988,
-0.011014534160494804,
0.014763127081096172,
-0.029574938118457794,
0.06611154973506927,
0.0029118533711880445,
0.010880655609071255,
0.010077386163175106,
0.015237786807119846,
-0.004208039026707411,
0.0026760450564324856,
-0.02095804177224636,
0.00915849395096302,
0.003194823395460844,
0.02648356556892395,
-0.03152225911617279,
-0.010412082076072693,
0.025047415867447853,
0.025534246116876602,
0.00006537027365993708,
0.012304634787142277,
0.013972028158605099,
-0.016223618760704994,
0.009048957377672195,
-0.0069495015777647495,
0.023659950122237206,
0.0015205838717520237,
0.014178930781781673,
-0.029647961258888245,
0.006456586066633463,
-0.011184925213456154,
0.013083563186228275,
-0.017185106873512268,
0.010862399823963642,
-0.011537876911461353,
-0.013168757781386375,
0.0037546781823039055,
-0.013765125535428524,
0.015481201931834221,
0.0046522715128958225,
-0.029769670218229294,
0.019716624170541763,
-0.034637972712516785,
-0.011507449671626091,
-0.01758674345910549,
-0.020020892843604088,
0.012408086098730564,
0.014203272759914398,
-0.0020599004346877337,
-0.012730610556900501,
0.0005906620062887669,
0.019278477877378464,
-0.011337059549987316,
-0.028990741819143295,
0.03290972486138344,
0.00467661302536726,
-0.0264592245221138,
-0.018840329721570015,
0.045226529240608215,
-0.012779293581843376,
-0.03312879800796509,
0.018791647627949715,
0.007466759067028761,
-0.0008808584534563124,
0.02621580846607685,
0.004707039799541235,
-0.044593650847673416,
0.009055042639374733,
0.013850320130586624,
0.017392011359333992,
-0.013083563186228275,
0.003115713596343994,
0.0030639879405498505,
-0.005202998407185078,
-0.004901771899312735,
-0.030305182561278343,
0.00461575947701931,
-0.009182835929095745,
-0.013886832632124424,
-0.002539123874157667,
0.014191101305186749,
-0.007247685454785824,
0.013205270282924175,
-0.0064322445541620255,
0.03660963475704193,
0.034272849559783936,
-0.0024843555875122547,
-0.025631612166762352,
-0.004390600137412548,
0.004551862832158804,
-0.024219805374741554,
0.012621073983609676,
-0.002793188439682126,
0.01570027507841587,
-0.004533606581389904,
0.022807996720075607,
-0.0044027711264789104,
-0.02154223807156086,
-0.017440693452954292,
0.0006960151367820799,
0.04361999034881592,
-0.03836222365498543,
-0.006274024955928326,
0.045469943434000015,
0.012572390958666801,
0.024146780371665955,
0.011653498746454716,
0.009493189863860607,
-0.004177612252533436,
-0.020726798102259636,
-0.013631246984004974,
0.01829264685511589,
0.0133513193577528,
-0.013765125535428524,
0.003462580032646656,
0.00925586000084877,
-0.034784022718667984,
-0.01770845055580139,
0.0264592245221138,
0.010533789172768593,
0.00399809330701828,
0.016491374000906944,
-0.029380206018686295,
0.011495279148221016,
-0.010107812471687794,
-0.014994371682405472,
0.013984198682010174,
0.008257858455181122,
0.00786230806261301,
0.016004543751478195,
-0.008063126355409622,
-0.007478929590433836,
0.02142053097486496,
-0.02770064026117325,
-0.0012649979908019304,
0.0073937345296144485,
-0.028771666809916496,
-0.046467944979667664,
0.01570027507841587,
-0.020629432052373886,
-0.02718946896493435,
-0.025315172970294952,
-0.005133016500622034,
-0.006912989541888237,
0.0026608314365148544,
0.002218120265752077,
-0.009207176975905895,
-0.02662961371243,
-0.03105976991355419,
0.00903678685426712,
-0.0009280201629735529,
0.02071462757885456,
0.029794011265039444,
0.008270028978586197,
0.006748684216290712,
0.015639422461390495,
0.0135825639590621,
0.014726614579558372,
-0.028820350766181946,
0.01804923079907894,
-0.02653224766254425,
0.0523829348385334,
-0.04880473017692566,
0.00675476947799325,
-0.023294826969504356,
-0.019826160743832588,
-0.014361492358148098,
-0.011458766646683216,
0.0054251146502792835,
0.03787539154291153,
-0.005781108979135752,
0.0023322212509810925,
0.014848322607576847,
0.014154589734971523,
-0.02757893316447735,
0.0064991838298738,
0.028163129463791847,
0.005984969437122345,
-0.022321166470646858,
0.004281063564121723,
-0.00826394371688366,
-0.00848301686346531,
0.017379838973283768,
-0.02738420106470585,
-0.022552410140633583,
0.035270851105451584,
-0.014957859180867672,
0.00836130976676941,
-0.02467012219130993,
0.015505542978644371,
0.022601094096899033,
-0.01329046580940485,
0.029404547065496445,
0.00974269025027752,
0.002044687047600746,
-0.025728978216648102,
-0.008203089237213135,
0.010278203524649143,
0.01643052138388157,
0.04264632984995842,
0.010430337861180305,
0.02558293007314205,
-0.014738786034286022,
0.006487012840807438,
-0.02073896862566471,
0.009444506838917732,
-0.024974390864372253,
-0.012292463332414627,
0.007418076042085886,
0.03716949000954628,
-0.04717385023832321,
-0.022637605667114258,
-0.0055802916176617146,
0.020264308899641037,
-0.01640617847442627,
0.01047902088612318,
0.014519711956381798,
0.004649228882044554,
0.002280495362356305,
-0.024925708770751953,
-0.0031887381337583065,
0.020799821242690086,
0.022430703043937683,
0.02726249396800995,
0.011586559936404228,
-0.0265079066157341,
0.020459040999412537,
0.02100672572851181,
0.018645597621798515,
-0.020970212295651436,
-0.029745327308773994,
0.030572939664125443,
0.00795967411249876,
-0.013752954080700874,
0.007917077280580997,
0.004363215994089842,
0.012018621899187565,
-0.040455594658851624,
0.05754333361983299,
-0.004366258624941111,
-0.015067395754158497,
-0.0008527135942131281,
-0.010126069188117981,
-0.017513718456029892,
-0.005665487144142389,
0.04133188724517822,
-0.0032739334274083376,
-0.009639238938689232,
-0.034832704812288284,
-0.014848322607576847,
0.002806880511343479,
0.011592645198106766,
0.012213353998959064,
-0.029769670218229294,
0.009182835929095745,
0.03123016096651554,
-0.05944197252392769,
-0.055790744721889496,
0.027408542111516,
-0.00023656907433178276,
0.001892552594654262,
-0.0077223447151482105,
-0.025509905070066452,
0.01958274655044079,
0.021164944395422935,
-0.029380206018686295,
-0.02338002249598503,
0.0014536447124555707,
0.02452407404780388,
-0.0015654634917154908,
-0.00019264024740550667,
0.012274207547307014,
-0.00825177226215601,
-0.03736422210931778,
0.0018240921199321747,
-0.019789649173617363,
0.01196993887424469,
0.01189691387116909,
0.0009074819972738624,
0.0064018177799880505,
0.050143513828516006,
0.01177520677447319,
0.011300547048449516,
-0.009815714322030544,
0.0007842531194910407,
0.021797824651002884,
-0.045421261340379715,
-0.017440693452954292,
0.009925251826643944,
-0.03604977950453758,
-0.00451839342713356,
-0.025315172970294952,
0.03629319369792938,
-0.02628883346915245,
0.03585504740476608,
0.006340963765978813,
0.03707212209701538,
-0.015067395754158497,
0.007375478278845549,
0.040406908839941025,
0.020751139149069786,
-0.022162945941090584,
0.020166942849755287,
0.017282472923398018,
-0.030645964667201042,
-0.010004361160099506,
0.02655659057199955,
-0.01846303790807724,
0.0026608314365148544,
0.004515350330621004,
0.04846395179629326,
-0.029550595209002495,
0.011428340338170528,
-0.00007226386514957994,
0.0030000912956893444,
0.01630881242454052,
0.011020619422197342,
-0.014069394208490849,
-0.03288538381457329,
0.004710082430392504,
-0.00931671354919672,
-0.014945688657462597,
-0.015116078779101372,
-0.014069394208490849,
-0.028552593663334846,
0.023002728819847107,
0.011221436783671379,
0.012888831086456776,
0.04824487864971161,
0.007795369252562523,
-0.028698643669486046,
0.027968397364020348,
0.005966713186353445,
-0.0064991838298738,
-0.04284106194972992,
-0.015274299308657646,
-0.025339514017105103,
-0.02359909564256668,
-0.008951591327786446,
-0.006821708753705025,
-0.03656095266342163,
0.0009934379486367106,
-0.007831881754100323,
-0.03794841840863228,
-0.016941692680120468,
0.03205777332186699,
-0.005701999180018902,
0.03118147701025009,
-0.02059291861951351,
-0.012079475447535515,
0.0032161222770810127,
0.034151140600442886,
0.00027650437550619245,
-0.02408592589199543,
0.01061289943754673,
0.002587806899100542,
0.023100094869732857,
-0.039822712540626526,
-0.028869032859802246,
0.022868851199746132,
-0.01074677798897028,
0.02459709718823433,
0.015529884956777096,
-0.01238374412059784,
-0.015785470604896545,
0.0260697603225708,
0.005385559517890215,
0.012657586485147476,
0.014118077233433723,
-0.0010208222083747387,
0.008489102125167847,
0.02176131121814251,
-0.03342089802026749,
-0.008671663701534271,
0.044350236654281616,
0.03300708904862404,
0.0023230931255966425,
0.012584561482071877,
0.03636622056365013,
-0.034735336899757385,
-0.015103908255696297,
0.01931498944759369,
-0.02073896862566471,
-0.029112448915839195,
-0.0012520665768533945,
0.0017875798512250185,
-0.01790318265557289,
0.008075296878814697,
-0.03733988106250763,
-0.011209266260266304,
0.005172571167349815,
0.011696096509695053,
0.015383835881948471,
0.04751463234424591,
-0.017562400549650192,
0.010692008771002293,
-0.0132296122610569,
-0.022698460146784782,
0.00919500645250082,
-0.016199275851249695,
-0.029380206018686295,
0.039506275206804276,
0.010053044185042381,
0.020045235753059387,
0.0027521122246980667,
0.022868851199746132,
0.00032062336686067283,
-0.009517530910670757,
-0.0031309269834309816,
0.00923151895403862,
0.008787285536527634,
-0.04320618510246277,
0.0018453908851370215,
0.006846050266176462,
0.007588466629385948,
0.0256802961230278,
0.0276032742112875,
0.054865770041942596,
-0.029015082865953445,
0.0017115125665441155,
-0.025655953213572502,
0.002230291021987796,
-0.025850685313344002,
0.010923253372311592,
0.12307068705558777,
-0.06270373612642288,
-0.015030884183943272,
-0.04335223138332367,
0.020398186519742012,
-0.03200908750295639,
-0.0013022709172219038,
0.008063126355409622,
0.02616712637245655,
-0.011233608238399029,
0.03142489120364189,
0.034297190606594086,
0.029185473918914795,
0.03234986960887909,
0.040309544652700424,
-0.015444689430296421,
-0.016174934804439545,
0.007746686227619648,
-0.011257949285209179,
0.002423501806333661,
-0.01348519790917635,
-0.010655497200787067,
-0.00018645978707354516,
0.03234986960887909,
0.015493372455239296,
-0.009809629060328007,
0.0033043602015823126,
-0.02633751556277275,
0.028674300760030746,
-0.014081564731895924,
0.009456677362322807,
-0.0010778725845739245,
0.0012170756235718727,
-0.018718622624874115,
0.017988378182053566,
-0.013935515657067299,
-0.016491374000906944,
-0.00588151765987277,
0.02411026693880558,
-0.0006351613556034863,
0.01096585113555193,
0.02180999517440796,
0.028747325763106346,
0.01364341750741005,
0.005285150837153196,
0.03660963475704193,
-0.029818352311849594,
0.0001402489433530718,
0.022929703816771507,
-0.03899510204792023,
0.020191283896565437,
0.013655588030815125,
0.0001234190713148564,
0.008915078826248646,
-0.005129973869770765,
-0.023976389318704605,
-0.0006499944138340652,
-0.0261184424161911,
-0.014458858408033848,
-0.023246144875884056,
-0.009006359614431858,
0.03617148846387863,
-0.0021435744129121304,
-0.0034990923013538122,
-0.0024250231217592955
] | 2024-07-16 | 18 | 39012598 | [
"gene expression",
"multiple genes",
"genome editing tools",
"target genes",
"CAR T cells",
"multiplex genome editing",
"genome editing",
"Multiplex gene regulation",
"epigenome editing",
"simultaneous genetic alterations",
"simultaneous activation",
"two T cell inhibitory genes",
"complex physiologic cellular pathways",
"complex cellular pathways",
"designer epigenome modifiers",
"such tools",
"DNA damage",
"DNA repair",
"genomic aberrations",
"multiplexed and sustainable gene",
"potential reversibility",
"increased resistance",
"PDCD1",
"B2M",
"cancer immunotherapy",
"three genes",
"superior fine-tuning capabilities",
"multiple single-strand or double-strand DNA breaks",
"concerns",
"the simultaneous inactivation"
] | [
"DNA methylation",
"Designer epigenome modifiers",
"Epigenome editing",
"Gene silencing",
"Transcription activator-like effectors"
] | 0 | 10.1007/978-1-0716-4051-7_11
10.1038/s41467-020-19505-2
10.1016/j.tibtech.2022.12.022
10.1007/s00439-023-02561-1
10.1038/s41587-022-01270-w
10.1093/nar/gky171
10.3389/fimmu.2023.1188049
10.1038/s41571-023-00754-1
10.1111/imm.13642
10.1038/s41467-020-17670-y
10.1158/0008-5472.can-11-1620
10.4049/jimmunol.1300271
10.1038/s41571-022-00600-w
10.1016/j.omto.2020.06.014
10.1038/srep04656
10.1007/978-1-4939-7774-1_4
10.1007/978-1-4939-7774-1_9
10.1016/j.cell.2021.03.025
10.1007/978-1-4939-7774-1_4
10.1006/meth.2001.1262 | [
"Azcona",
"Mussolino"
] | [
"Institute for Transfusion Medicine and Gene Therapy, Center for Chronic Immunodeficiency & Medical Center, University of Freiburg, Freiburg, Germany.",
"Institute for Transfusion Medicine and Gene Therapy, Center for Chronic Immunodeficiency & Medical Center, University of Freiburg, Freiburg, Germany. [email protected]."
] | [
"39012598",
"33199717",
"36709094",
"37093294",
"29538770",
"37256141",
"37055515",
"36942414",
"32732879",
"22186141",
"23536636",
"35082367",
"32728611",
"24722320",
"29524130",
"29524135",
"33838111",
"11846609"
] | [] | 9.351851 | 2.853548 |
39012374 | 723 | Riding the storm: managing cytokine-related toxicities in CAR-T cell therapy. | The advent of chimeric antigen receptor T cells (CAR-T) has been a paradigm shift in cancer immunotherapeutics, with remarkable outcomes reported for a growing catalog of malignancies. While CAR-T are highly effective in multiple diseases, salvaging patients who were considered incurable, they have unique toxicities which can be life-threatening. Understanding the biology and risk factors for these toxicities has led to targeted treatment approaches which can mitigate them successfully. The three toxicities of particular interest are cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and immune effector cell-associated hemophagocytic lymphohistiocytosis (HLH)-like syndrome (IEC-HS). Each of these is characterized by cytokine storm and hyperinflammation; however, they differ mechanistically with regard to the cytokines and immune cells that drive the pathophysiology. We summarize the current state of the field of CAR-T-associated toxicities, focusing on underlying biology and how this informs toxicity management and prevention. We also highlight several emerging agents showing promise in preclinical models and the clinic. Many of these established and emerging agents do not appear to impact the anti-tumor function of CAR-T, opening the door to additional and wider CAR-T applications. | [
0.0016098672058433294,
0.00469996826723218,
0.04442510008811951,
0.055856965482234955,
-0.04570334777235985,
-0.02701200358569622,
0.008525663986802101,
-0.009592879563570023,
-0.0019610836170613766,
-0.002610758412629366,
0.004118124954402447,
-0.010961567983031273,
-0.06671000272035599,
0.0007227821624837816,
-0.002675575204193592,
-0.049345143139362335,
0.028024954721331596,
-0.0032951028551906347,
0.029930265620350838,
0.03861269727349281,
-0.0032378227915614843,
0.04215802252292633,
-0.005866669584065676,
0.023997271433472633,
-0.02439521625638008,
-0.006156084127724171,
0.0039040788542479277,
0.01344570703804493,
-0.015266605652868748,
0.004953205585479736,
0.04838043078780174,
-0.017413096502423286,
-0.005538064055144787,
-0.021211659535765648,
0.00476026302203536,
0.033379118889570236,
0.029616734012961388,
0.026650236919522285,
-0.024009330198168755,
-0.016870444640517235,
0.03036438673734665,
0.05349341407418251,
0.013795416802167892,
0.10139148682355881,
-0.07061709463596344,
-0.021187540143728256,
0.010913331992924213,
-0.03583914041519165,
0.009321553632616997,
0.032631464302539825,
-0.02375609241425991,
0.018944580107927322,
-0.01859487034380436,
0.042085666209459305,
-0.04046976938843727,
0.038636814802885056,
-0.017835158854722977,
0.03429559990763664,
0.001461391686461866,
-0.025396106764674187,
0.019583703950047493,
-0.01998164691030979,
-0.00651785172522068,
-0.030967334285378456,
-0.054265186190605164,
-0.003879960859194398,
-0.05315576493740082,
-0.032631464302539825,
-0.006777118891477585,
0.01113642193377018,
0.01860692910850048,
-0.02228490263223648,
0.006385203916579485,
0.0214407779276371,
0.05412048101425171,
-0.005106957163661718,
-0.029134375974535942,
0.011974518187344074,
0.021573426201939583,
-0.03815445676445961,
0.05079221352934837,
0.00033934583188965917,
-0.003858857788145542,
-0.03359618037939072,
-0.023418443277478218,
0.00004043981243739836,
-0.007277564611285925,
-0.04780159890651703,
-0.047343362122774124,
0.003620693925768137,
-0.04444921761751175,
0.01808839663863182,
-0.03670738264918327,
0.03487442806363106,
-0.022357257083058357,
0.021054891869425774,
-0.0049079847522079945,
-0.025203164666891098,
0.030943214893341064,
0.045655108988285065,
0.06487704813480377,
-0.00010353722609579563,
-0.04654747247695923,
0.0022700936533510685,
0.038829755038022995,
0.018353691324591637,
-0.05402400717139244,
-0.003892019856721163,
0.0336444154381752,
-0.015218370594084263,
0.05474754422903061,
-0.011896135285496712,
-0.04847690090537071,
0.09053844958543777,
-0.05349341407418251,
-0.05180516466498375,
-0.05286635085940361,
0.00887537281960249,
-0.003120248205959797,
0.01965605653822422,
-0.0226949080824852,
0.019812822341918945,
0.051322806626558304,
0.021802546456456184,
-0.014760131016373634,
-0.030147327110171318,
0.05990876629948616,
-0.024527864530682564,
-0.020114295184612274,
-0.0835925042629242,
0.04068683087825775,
-0.01660514809191227,
0.010201855562627316,
-0.018329573795199394,
-0.03808210417628288,
-0.009080374613404274,
-0.010575681924819946,
-0.020524298772215843,
-0.036297380924224854,
-0.0458480529487133,
0.009924500249326229,
-0.0005776981124654412,
0.009665233083069324,
0.0036387823056429625,
-0.006222408264875412,
-0.0452209897339344,
0.009424054063856602,
0.023526974022388458,
-0.005845566745847464,
0.046185702085494995,
-0.008803019300103188,
0.058365222066640854,
0.033065587282180786,
0.00373223889619112,
0.014012477360665798,
-0.05894405394792557,
0.018016042187809944,
0.06849472224712372,
-0.02323755994439125,
-0.07220887392759323,
0.002279137959703803,
-0.01539925392717123,
-0.05156398564577103,
-0.03774445131421089,
0.00651785172522068,
-0.013457766734063625,
-0.0003357658570166677,
0.04153095558285713,
-0.032534994184970856,
-0.013071880675852299,
-0.02513081021606922,
-0.05653226748108864,
-0.07587479054927826,
-0.021911077201366425,
-0.05913699418306351,
-0.017485449090600014,
-0.004802469164133072,
0.02522728219628334,
-0.020524298772215843,
-0.009128610603511333,
0.021464895457029343,
0.015218370594084263,
0.011805692687630653,
-0.025154929608106613,
-0.04804277792572975,
-0.000622542283963412,
-0.016834266483783722,
0.021826663985848427,
-0.03743091970682144,
-0.026409057900309563,
0.008447281084954739,
-0.00845933984965086,
0.035887375473976135,
0.0008983903098851442,
0.00375635689124465,
-0.01765427365899086,
0.00754286115989089,
0.04686100408434868,
-0.016231320798397064,
-0.04982750117778778,
0.039480939507484436,
-0.0005486813606694341,
-0.006982120685279369,
0.009942588396370411,
-0.01754574477672577,
0.00898390356451273,
-0.028121426701545715,
0.050309859216213226,
-0.015194252133369446,
0.010997744277119637,
0.03890211135149002,
0.0031895870342850685,
-0.009086403995752335,
0.05079221352934837,
-0.01889634318649769,
-0.018679283559322357,
-0.006765060126781464,
0.05267340689897537,
0.005061735864728689,
0.010563623160123825,
0.010786713100969791,
-0.01723221130669117,
0.002460021758452058,
0.01923399418592453,
-0.03743091970682144,
0.005393356550484896,
0.003421721514314413,
-0.019511349499225616,
0.034633249044418335,
-0.015700727701187134,
-0.0189325213432312,
0.019270170480012894,
0.029375554993748665,
-0.027711423113942146,
-0.0679158940911293,
-0.01902899146080017,
0.016966914758086205,
0.03132910281419754,
0.05551931634545326,
-0.011817751452326775,
0.029182611033320427,
0.012294079177081585,
-0.003485030960291624,
-0.019993707537651062,
-0.004579378757625818,
-0.0016083598602563143,
0.014205420389771461,
-0.08479839563369751,
0.006186231505125761,
-0.0046185702085494995,
0.017425155267119408,
0.008133748546242714,
0.019402818754315376,
-0.01219760812819004,
0.029254965484142303,
-0.009809940122067928,
0.03880563750863075,
-0.06207937374711037,
-0.0017711553955450654,
-0.014386303722858429,
0.015387195162475109,
0.004422612953931093,
-0.016436321660876274,
-0.050068680197000504,
-0.0679158940911293,
0.009538614191114902,
0.007205211091786623,
-0.010461121797561646,
0.008977874182164669,
-0.0009797881357371807,
0.05276988074183464,
0.05127457156777382,
0.0262884683907032,
-0.030653800815343857,
-0.06497351825237274,
0.036104436963796616,
0.0003406647883821279,
0.04657159000635147,
-0.017316624522209167,
0.030653800815343857,
-0.0012285035336390138,
-0.021211659535765648,
-0.002460021758452058,
-0.04782572016119957,
-0.01277040783315897,
-0.018341632559895515,
-0.00140637275762856,
-0.010117442347109318,
-0.006415350828319788,
-0.04891102388501167,
0.00036666684900410473,
-0.009701409377157688,
-0.036731503903865814,
-0.033692650496959686,
-0.004353274125605822,
0.024033447727560997,
0.00839904509484768,
0.015411313623189926,
-0.04182036966085434,
-0.021151363849639893,
-0.053445179015398026,
0.0008629672229290009,
-0.051756929606199265,
-0.05074397847056389,
0.04825983941555023,
-0.006728883367031813,
-0.01714779995381832,
-0.021380484104156494,
0.029134375974535942,
0.036225028336048126,
0.010840978473424911,
-0.018040159717202187,
0.037237975746393204,
0.0036990768276154995,
-0.0016822208417579532,
0.016653383150696754,
0.02689141407608986,
-0.033186174929142,
0.03699680045247078,
-0.0018450163770467043,
-0.011045980267226696,
-0.004886881448328495,
-0.022779319435358047,
0.002862488618120551,
0.0048356312327086926,
-0.03706915304064751,
0.028844961896538734,
0.002773554064333439,
0.03521207720041275,
-0.03188381344079971,
0.0015767051372677088,
-0.052191052585840225,
0.05016515031456947,
-0.01082289032638073,
0.01701515167951584,
-0.036610912531614304,
-0.04075918346643448,
-0.051129866391420364,
0.0179919246584177,
-0.023768151178956032,
-0.005752109922468662,
0.024250509217381477,
-0.03731033205986023,
0.061307601630687714,
-0.009363759309053421,
-0.026529647409915924,
-0.025396106764674187,
-0.0013332654489204288,
-0.007802127860486507,
0.030436741188168526,
-0.00014828715939074755,
0.021609604358673096,
-0.021284012123942375,
0.02742200717329979,
-0.022646671161055565,
0.03952917456626892,
-0.04830807447433472,
-0.008169925771653652,
0.013686886057257652,
-0.000680952740367502,
0.004383421037346125,
0.007627273444086313,
-0.03844387084245682,
0.07360771298408508,
0.041989196091890335,
0.048597488552331924,
-0.040831539779901505,
0.045462168753147125,
-0.042953912168741226,
-0.03738268464803696,
-0.01255334634333849,
-0.018040159717202187,
0.013735122047364712,
-0.005824463441967964,
-0.025082575157284737,
0.03781680762767792,
0.013807475566864014,
-0.014663659036159515,
0.023671681061387062,
-0.0032167197205126286,
0.036200910806655884,
-0.004350258968770504,
-0.00982199888676405,
-0.016146907582879066,
-0.0037020917516201735,
0.027904365211725235,
-0.0009428576449863613,
-0.02439521625638008,
-0.0647805780172348,
0.05088868737220764,
0.004166360478848219,
-0.028965551406145096,
-0.010069207288324833,
-0.003433780511841178,
-0.011691133491694927,
0.09087610244750977,
-0.04920043796300888,
0.0810842514038086,
0.04842866584658623,
-0.012046871706843376,
0.018257221207022667,
-0.008839195594191551,
-0.028941433876752853,
-0.03897446393966675,
0.02995438314974308,
0.007802127860486507,
0.03321029618382454,
0.034512657672166824,
0.01995752938091755,
-0.04403921589255333,
0.05537460744380951,
0.01034656260162592,
0.025999054312705994,
0.020222825929522514,
0.021476956084370613,
-0.0695076733827591,
-0.05233575776219368,
0.020246943458914757,
-0.01746133156120777,
0.05855816602706909,
0.02513081021606922,
-0.03554972633719444,
-0.004410553723573685,
-0.00945420190691948,
-0.011872016824781895,
-0.0018842079443857074,
0.026939650997519493,
-0.009942588396370411,
0.02112724632024765,
-0.05170869454741478,
-0.033475592732429504,
0.08455722033977509,
0.0022625569254159927,
0.0046185702085494995,
0.003542310791090131,
0.03246264159679413,
-0.012022753246128559,
0.02826613374054432,
-0.01890840381383896,
0.008977874182164669,
-0.017473390325903893,
0.01723221130669117,
0.006053583230823278,
0.0067107947543263435,
0.0435086227953434,
-0.010895243845880032,
0.015471607446670532,
0.003261940786615014,
-0.003210690338164568,
-0.005972185172140598,
-0.010099354200065136,
-0.002503735478967428,
-0.005339091643691063,
-0.006535940337926149,
-0.03593561425805092,
-0.014398363418877125,
-0.004103051032871008,
-0.05305929481983185,
0.00804330687969923,
0.016134848818182945,
0.035911496728658676,
-0.035380903631448746,
0.028000837191939354,
-0.004087977577000856,
-0.008694488555192947,
0.02542022615671158,
0.04411156848073006,
-0.022357257083058357,
-0.010424945503473282,
-0.02216431498527527,
0.02679494395852089,
-0.01344570703804493,
-0.02343050204217434,
0.00015704872203059494,
0.015363077633082867,
0.0168222077190876,
0.016134848818182945,
0.02039165236055851,
0.028869079425930977,
0.028507310897111893,
-0.005076809786260128,
0.004054815508425236,
-0.03687620908021927,
-0.004543201997876167,
0.04235096275806427,
0.04869396239519119,
-0.024841396138072014,
-0.0024570070672780275,
-0.034416187554597855,
0.04025271162390709,
-0.007102710194885731,
0.003997535444796085,
0.014121007174253464,
-0.011281129904091358,
-0.01881193183362484,
-0.0032679701689630747,
-0.02384050562977791,
-0.007585067301988602,
0.004522099159657955,
-0.0028172675520181656,
0.027976717799901962,
-0.005100927781313658,
0.0019053110154345632,
0.01272217184305191,
0.046523354947566986,
0.05045456439256668,
0.013855711556971073,
0.0788654088973999,
-0.0020982539281249046,
0.016942797228693962,
-0.030967334285378456,
-0.01355423778295517,
0.022417550906538963,
-0.0029016800690442324,
-0.04353274032473564,
-0.04886278510093689,
-0.03887799009680748,
-0.03354794532060623,
-0.012758348137140274,
-0.013867770321667194,
-0.004133198410272598,
0.0056375497952103615,
-0.0028202824760228395,
0.008067424409091473,
0.03509148955345154,
-0.01597808301448822,
-0.01161274965852499,
0.009653174318373203,
-0.025806110352277756,
-0.06453939527273178,
0.03952917456626892,
-0.02563728578388691,
-0.009273317642509937,
0.026987886056303978,
-0.025275519117712975,
-0.006089759990572929,
-0.027301419526338577,
-0.0006297022919170558,
-0.042929790914058685,
-0.02060871198773384,
0.01261364109814167,
-0.024443451315164566,
0.032969117164611816,
-0.0010378217557445168,
-0.004901955369859934,
0.010503328405320644,
-0.0075730085372924805,
-0.01618308387696743,
0.015242488123476505,
-0.011865987442433834,
0.013421589508652687,
-0.04268861562013626,
-0.0003632752923294902,
-0.009846116416156292,
0.00472710095345974,
-0.018763694912195206,
-0.011932311579585075,
-0.050068680197000504,
-0.01460336521267891,
-0.0018615974113345146,
-0.02186284027993679,
-0.034512657672166824,
-0.012432757765054703,
-0.014000418595969677,
-0.03149792551994324,
0.005866669584065676,
0.007651391439139843,
-0.0007393631967715919,
-0.02450374700129032,
0.010370680131018162,
-0.006578146480023861,
-0.021175481379032135,
0.004953205585479736,
-0.025878464803099632,
0.02923084795475006,
-0.009532584808766842,
-0.010907302610576153,
0.015194252133369446,
0.004000550135970116,
0.013059821911156178,
-0.02207990176975727,
-0.029496144503355026,
-0.0111906873062253,
0.03656267747282982,
-0.007205211091786623,
0.0291102584451437,
-0.033065587282180786,
-0.011027892120182514,
-0.019619880244135857,
-0.016593087464571,
0.023201381787657738,
-0.0023952049668878317,
0.04572746530175209,
0.02103077434003353,
-0.0297373216599226,
0.014048653654754162,
0.0613558366894722,
-0.029062023386359215,
-0.012312168255448341,
0.028338486328721046,
-0.007627273444086313,
-0.024214332923293114,
-0.02460021898150444,
-0.05127457156777382,
-0.037455037236213684,
0.03195616602897644,
0.00009477565617999062,
-0.011383630335330963,
0.004241728689521551,
0.02889319695532322,
0.027397889643907547,
0.026312585920095444,
-0.024720806628465652,
-0.008085512556135654,
0.020765477791428566,
0.007856393232941628,
-0.03583914041519165,
-0.005556152202188969,
0.014579246751964092,
-0.02082577347755432,
-0.0008652282413095236,
0.007633302826434374,
-0.02573375776410103,
-0.004078933037817478,
0.021296070888638496,
-0.04087977483868599,
0.006481674965471029,
-0.023985212668776512,
0.012951291166245937,
-0.0033252499997615814,
-0.0034820162691175938,
-0.0428815558552742,
-0.01627955585718155,
0.03393382951617241,
-0.010177737101912498,
-0.0016128818970173597,
0.020005766302347183,
-0.012233785353600979,
-0.029882030561566353,
0.0094662606716156,
-0.020427828654646873,
-0.006499763578176498,
-0.004983352962881327,
-0.020114295184612274,
0.024744926020503044,
-0.02879672683775425,
-0.023611385375261307,
-0.0021977401338517666,
0.024443451315164566,
0.01574896275997162,
0.005242620129138231,
-0.02807318978011608,
0.005740050692111254,
-0.029399672523140907,
0.008965814486145973,
-0.016460439190268517,
0.00887537281960249,
-0.0074463896453380585,
0.045341577380895615,
0.08610076457262039,
-0.015290724113583565,
-0.01219760812819004,
-0.013518061488866806,
0.003099145134910941,
0.027880247682332993,
0.005140119232237339,
0.03026791475713253,
-0.004103051032871008,
0.011395689100027084,
0.008845225907862186,
0.057979337871074677,
0.0233219712972641,
0.01935458369553089,
-0.0006805759039707482,
0.011962459422647953,
0.019499290734529495,
0.020729301497340202,
-0.010322444140911102,
-0.027397889643907547,
0.03224558010697365,
-0.03236616775393486,
0.023780211806297302,
-0.01995752938091755,
-0.08084306865930557,
0.017473390325903893,
0.005788286682218313,
0.0168222077190876,
0.00279917917214334,
0.020777536556124687,
-0.013276882469654083,
-0.009442142210900784,
0.0056074028834700584,
-0.0344403050839901,
-0.00898993294686079,
0.014844543300569057,
0.008905519731342793,
-0.03282440826296806,
-0.005043647717684507,
-0.004401509650051594,
-0.010141560807824135,
0.023695798590779305,
0.01889634318649769,
0.026191996410489082,
-0.03521207720041275,
0.03135322034358978,
-0.012806584127247334,
0.010961567983031273,
-0.01124495267868042,
0.020464004948735237,
0.025082575157284737,
-0.020234884694218636,
0.012842761352658272,
-0.00026868804707191885,
-0.01701515167951584,
-0.027470244094729424,
0.008652282878756523,
-0.006165128201246262,
0.03007497265934944,
0.007452419027686119,
0.00043864359031431377,
-0.0017334712902083993,
0.023997271433472633,
-0.03511560708284378,
0.015351018868386745,
0.01953546702861786,
0.02575787529349327,
-0.033041469752788544,
0.029689086601138115,
-0.01177554577589035,
-0.016749855130910873,
0.01302364468574524,
-0.04256802424788475,
-0.03731033205986023,
-0.01755780354142189,
-0.011703192256391048,
0.02205578424036503,
-0.02164578065276146,
-0.03214910998940468,
-0.027301419526338577,
-0.000921000842936337,
0.03492266312241554,
-0.01640014536678791,
-0.003469957271590829,
0.0168222077190876,
0.010153619572520256,
0.02491375058889389,
0.018438104540109634,
0.017485449090600014,
0.005405415780842304,
-0.024564040824770927,
0.017798980697989464,
0.009213022887706757,
-0.02415403723716736,
-0.007548890542238951,
0.010201855562627316,
-0.02544434368610382,
0.003632752923294902,
-0.0015646462561562657,
-0.00651182234287262,
-0.024564040824770927,
-0.021597543731331825,
-0.002746421378105879,
-0.011263040825724602,
0.002028915099799633,
0.012034812942147255,
-0.01366276852786541,
0.01828133873641491,
0.04090389236807823,
-0.01900487393140793,
0.03123263083398342,
-0.03287264332175255,
-0.020259004086256027,
-0.010581711307168007,
-0.022116078063845634,
-0.01461542397737503,
0.016556911170482635,
-0.03036438673734665,
-0.006409321445971727,
-0.001459884224459529,
-0.011389659717679024,
-0.000826790404971689,
-0.012541287578642368,
-0.007223299238830805,
0.01118465792387724,
-0.0053541650995612144,
-0.016014259308576584,
-0.005655638407915831,
0.016870444640517235,
-0.019149580970406532,
-0.023912860080599785,
-0.007211240474134684,
0.04466627910733223,
-0.01608661375939846,
0.017292506992816925,
-0.009291405789554119,
0.03142557293176651,
0.024564040824770927,
-0.0870172455906868,
-0.010280238464474678,
-0.009321553632616997,
-0.00939993653446436,
0.019402818754315376,
-0.0034880456514656544,
-0.06106642261147499,
0.016110731288790703,
0.014326008968055248,
-0.03668326511979103,
0.011697162874042988,
-0.017678391188383102,
0.0011704699136316776,
0.0010928405681625009,
-0.01561631541699171,
-0.030195562168955803,
-0.013747180812060833,
-0.03417500853538513,
-0.025830229744315147,
0.028676137328147888,
-0.015133957378566265,
0.0131442341953516,
-0.010840978473424911,
0.07399360090494156,
0.014434539712965488,
0.011413777247071266,
-0.02334608882665634,
-0.0300508551299572,
-0.0405421257019043,
0.0050285737961530685,
0.008447281084954739,
0.012842761352658272,
-0.01609867252409458,
0.03403030335903168,
-0.0021947254426777363,
-0.019318407401442528,
0.03070203773677349,
0.004350258968770504,
-0.021730192005634308,
-0.015146017074584961,
0.008911550045013428,
0.01901693269610405,
0.03436795249581337,
0.0063912332989275455,
-0.02092224359512329,
-0.0196439977735281,
-0.030219679698348045,
0.005734021309763193,
0.01755780354142189,
-0.009327583014965057,
0.018872225657105446,
-0.011974518187344074,
-0.023177264258265495,
-0.01277040783315897,
-0.005887772887945175,
0.01986105926334858,
-0.00517328130081296,
0.02795260027050972,
-0.0006598496111109853,
0.0272290650755167,
-0.022465787827968597,
0.03439207002520561,
0.01071435958147049,
-0.006885649170726538,
0.0030901008285582066,
-0.013819534331560135,
-0.052914585918188095,
0.015700727701187134,
-0.05161222070455551,
0.01902899146080017,
0.0006508054211735725,
0.01566455140709877,
-0.04068683087825775,
0.01756986230611801,
-0.0002978932752739638,
0.008893460966646671,
-0.02124783582985401,
-0.017702510580420494,
0.0076935975812375546,
0.03070203773677349,
-0.01618308387696743,
-0.03533266484737396,
-0.005586299579590559,
0.020234884694218636,
-0.019089287146925926,
0.010370680131018162,
0.0007672494393773377,
0.029978500679135323,
0.013108057901263237,
-0.0018103469628840685,
-0.011106275022029877,
-0.008332720957696438,
0.013433648273348808,
0.0002990237844642252,
0.004778351169079542,
-0.013940123841166496,
-0.036417968571186066,
0.003858857788145542,
-0.00704241544008255,
-0.029086140915751457,
0.03755151107907295,
-0.045028045773506165,
0.017388977110385895,
-0.03593561425805092,
-0.024986103177070618,
-0.016207203269004822,
0.0018992815166711807,
0.011009803973138332,
0.006288732402026653,
-0.009623026475310326,
0.011341423727571964,
-0.02415403723716736,
0.016110731288790703,
-0.028676137328147888,
0.011679073795676231,
-0.020126355811953545,
0.012987468391656876,
-0.02216431498527527,
0.023816388100385666,
0.00019369657093193382,
0.0635264441370964,
0.025251399725675583,
-0.006771089509129524,
0.0017018165672197938,
0.00748859578743577,
0.012975409626960754,
-0.008616105653345585,
0.023406384512782097,
0.02648141048848629,
0.004787395242601633,
0.00567674171179533,
-0.018438104540109634,
0.017630156129598618,
-0.0158816110342741,
-0.00517931068316102,
0.051226336508989334,
0.028000837191939354,
-0.000009686005796538666,
0.0013272360665723681,
0.02544434368610382,
0.007778010331094265,
-0.004311067517846823,
-0.009092433378100395,
-0.014627482742071152,
0.015736903995275497,
-0.02027106285095215,
-0.051756929606199265,
0.029086140915751457,
0.012794525362551212,
0.00883316621184349,
-0.03395794704556465,
-0.0006877358537167311,
0.05653226748108864,
0.048597488552331924,
0.014410422183573246,
0.018522517755627632,
0.030822627246379852,
-0.007380065508186817,
-0.03154616057872772,
0.0010604321723803878,
-0.03501913323998451,
0.039046816527843475,
-0.022634612396359444,
-0.002050018170848489,
0.02785613015294075,
-0.02059665322303772,
-0.001223227707669139,
0.002074135933071375,
0.01934252493083477,
0.012348344549536705,
0.01566455140709877,
-0.0716782808303833,
0.037358567118644714,
-0.013650709763169289,
-0.03870916739106178,
0.017171917483210564,
0.006258585024625063,
0.011287159286439419,
0.014482775703072548,
0.027880247682332993,
-0.04830807447433472,
0.02218843251466751,
0.029882030561566353,
0.03453677520155907,
0.03475383669137955,
-0.023912860080599785,
-0.011697162874042988,
-0.03656267747282982,
-0.013047763146460056,
-0.015809258446097374,
-0.016231320798397064,
-0.030822627246379852,
0.002726825652644038,
0.07283593714237213,
0.018570752814412117,
-0.05310752987861633,
-0.01566455140709877,
-0.010479210875928402,
-0.04097624495625496,
-0.0330173522233963,
-0.033162057399749756,
0.049779266119003296,
0.057738158851861954,
-0.012987468391656876,
-0.004473863169550896,
0.023490795865654945,
0.005462695378810167,
-0.016894562169909477,
0.017895452678203583,
0.03333088383078575,
0.00707256281748414,
0.0378650426864624,
-0.028869079425930977,
0.04237508028745651,
0.007699626963585615,
0.004277905449271202,
0.020307239145040512,
-0.00469996826723218,
-0.028459075838327408,
-0.008386986330151558,
-0.0532039999961853,
-0.04403921589255333,
0.01743721403181553,
0.012269961647689342,
-0.008103601634502411,
0.004814527928829193,
0.02271902561187744,
0.026674354448914528,
-0.02028312161564827,
-0.0006055844132788479,
-0.008320662193000317,
0.005314973648637533,
0.029785558581352234,
-0.009803910739719868,
0.01722015254199505,
-0.011618779972195625,
-0.007651391439139843,
-0.011009803973138332,
0.03171498700976372,
0.01261364109814167,
0.031136158853769302,
0.014096889644861221,
0.002775061409920454,
-0.03834740072488785,
-0.026095526292920113,
-0.008242279291152954,
0.043460384011268616,
-0.019209876656532288,
-0.003343338379636407,
-0.019788704812526703,
-0.020307239145040512,
-0.0030448799952864647,
0.045148637145757675,
0.028434958308935165,
0.01713573932647705,
-0.014060713350772858,
0.017183976247906685,
0.0297373216599226,
0.028724372386932373,
-0.007380065508186817,
-0.002922783372923732,
-0.009701409377157688,
-0.015736903995275497,
-0.004295994061976671,
0.014108948409557343,
-0.0036870180629193783,
0.007615214679390192,
-0.009990823455154896,
0.007946834899485111,
0.012818642891943455,
0.008188013918697834,
0.0040518008172512054,
-0.021284012123942375,
-0.004980338271707296,
-0.03342735394835472,
-0.007759921718388796,
0.010853037238121033,
-0.009574790485203266,
-0.005851596128195524,
-0.008091541938483715,
-0.0002596438571345061,
0.018028100952506065,
-0.012842761352658272,
-0.002078658202663064,
0.021259894594550133,
0.013771298341453075,
-0.018570752814412117,
-0.03333088383078575,
-0.009092433378100395,
0.009701409377157688,
-0.037575628608465195,
0.00983405765146017,
-0.019149580970406532,
-0.028024954721331596,
-0.01491689682006836,
-0.030340269207954407,
0.010087295435369015,
0.015604255720973015,
0.0018389868782833219,
-0.0113474540412426,
-0.007120798341929913,
0.030629683285951614,
0.005498872138559818,
-0.007126827724277973,
-0.023273736238479614,
-0.016568969935178757,
-0.018474280834197998,
-0.03460913151502609,
0.03952917456626892,
-0.009598908945918083,
-0.02744612656533718,
0.00701829744502902,
0.011944370344281197,
-0.008326691575348377,
0.03166675195097923,
0.008236249908804893,
-0.01679809018969536,
0.0024539923761039972,
0.009647144004702568,
0.00850757583975792,
-0.0205001812428236,
-0.009900381788611412,
0.010105383582413197,
-0.018474280834197998,
-0.030943214893341064,
-0.010069207288324833,
0.012830701656639576,
-0.0030373430345207453,
-0.008604046888649464,
-0.007132857572287321,
0.015471607446670532,
-0.011335394345223904,
-0.0027569730300456285,
0.0031172335147857666,
0.004250773228704929,
-0.0040156240575015545,
0.00375937158241868,
-0.02775965817272663,
0.01230010949075222,
0.011841869913041592,
-0.018631048500537872,
-0.0004970540176145732,
0.008013159036636353,
0.0053541650995612144,
0.026553764939308167,
-0.01599014177918434,
-0.038106221705675125,
-0.029978500679135323,
-0.027711423113942146,
-0.01629161462187767,
0.051033392548561096,
-0.028121426701545715,
-0.03497089818120003,
0.030846744775772095,
0.005556152202188969,
-0.016629265621304512,
-0.00987626425921917,
0.0319320484995842,
-0.012372463010251522,
-0.00604152400046587,
-0.008284484967589378,
0.042519789189100266,
0.03518795967102051,
-0.025082575157284737,
0.005966155789792538,
0.01923399418592453,
-0.012637759558856487,
-0.004500995855778456,
-0.012541287578642368,
0.003584517166018486,
0.005866669584065676,
-0.006433439441025257,
-0.03627326339483261,
-0.008019188418984413,
0.01119671668857336,
0.026867296546697617,
0.047222770750522614,
0.006867561023682356,
-0.0038829755503684282,
0.020536359399557114,
0.005411445163190365,
-0.03135322034358978,
-0.00609277468174696,
-0.016327792778611183,
-0.01460336521267891,
0.006795207504183054,
-0.019294288009405136,
-0.021886959671974182,
0.004265846684575081,
0.00162946293130517,
0.006198290269821882,
-0.014687777496874332,
0.005450636614114046,
-0.00701226806268096,
-0.011395689100027084,
0.014904838055372238,
-0.022936085239052773,
0.012257902882993221,
-0.02363550290465355,
0.016653383150696754,
-0.04628217592835426,
-0.03217322751879692,
0.006270643789321184,
-0.012915114872157574,
0.006270643789321184,
0.0025791036896407604,
0.009146698750555515,
0.019728410989046097,
0.018679283559322357,
0.02976144105195999,
-0.029086140915751457,
-0.0065721170976758,
-0.06019818037748337,
0.011263040825724602,
-0.03439207002520561,
0.03480207175016403,
0.026746707037091255,
-0.003485030960291624,
-0.005758139304816723,
0.0028670106548815966,
0.01082289032638073,
0.011112304404377937,
-0.002030422445386648,
-0.002490169135853648,
-0.011793633922934532,
0.0205845944583416,
0.0023831462021917105,
0.02250196412205696,
-0.032727938145399094,
0.03608031943440437,
0.005061735864728689,
0.012517170049250126,
0.003964373376220465,
-0.005809389986097813,
-0.023695798590779305,
0.013228646479547024,
0.004338200204074383,
0.0012413162039592862,
-0.010708330199122429,
-0.008905519731342793,
0.003156424965709448,
0.001466667396016419,
0.043870389461517334,
0.005966155789792538,
-0.008007129654288292,
-0.017485449090600014,
0.00024362807744182646,
-0.023309912532567978,
0.02829025126993656,
0.017919570207595825,
0.030316151678562164,
0.022526081651449203,
-0.005740050692111254,
-0.02279137820005417,
-0.020126355811953545,
-0.018631048500537872,
-0.026722589507699013,
0.006970061920583248,
0.007398153655230999,
0.012022753246128559,
-0.004440701100975275,
-0.008531693369150162,
-0.0082965437322855,
0.017292506992816925,
-0.003629737999290228,
-0.0057008592411875725,
-0.011389659717679024,
-0.029713204130530357,
-0.036417968571186066,
0.0067831482738256454,
-0.003828710410743952,
0.025685522705316544,
0.01629161462187767,
-0.007808157708495855,
0.03120851144194603,
-0.004823572002351284,
0.018136631697416306,
0.01713573932647705,
0.016978973522782326,
-0.014543070457875729,
-0.008646253496408463,
0.020632829517126083,
-0.015049545094370842,
-0.03342735394835472,
0.023924918845295906,
0.005082839168608189,
0.0051250453107059,
-0.009219052270054817,
0.035356782376766205,
0.022622553631663322,
-0.03583914041519165,
-0.01087715569883585,
-0.01744927279651165,
-0.01125098206102848,
-0.005815419368445873,
-0.0008403566898778081,
0.0036900327540934086,
-0.024841396138072014,
-0.01219760812819004,
0.0010724911699071527,
0.003545325482264161,
-0.005260708276182413,
0.008386986330151558,
0.0054807839915156364,
0.005106957163661718,
-0.002074135933071375,
-0.03938446566462517,
-0.05928170308470726,
0.005429533310234547,
-0.006439468823373318,
-0.01817280799150467,
-0.005305929575115442,
-0.008543752133846283,
0.005932993721216917,
0.05412048101425171,
-0.02133224718272686,
-0.008845225907862186,
0.040180355310440063,
0.04958632215857506,
0.011540396139025688,
-0.0020620771683752537,
0.004003564827144146,
0.013988358899950981,
0.002316822065040469,
0.016581028699874878,
-0.000472559331683442,
0.02271902561187744,
0.011540396139025688,
-0.0064274100586771965,
0.012987468391656876,
0.0131442341953516,
-0.004549231380224228,
0.007313741371035576,
-0.002969511551782489,
-0.019499290734529495,
0.05035809427499771,
-0.019390759989619255,
-0.020644888281822205,
-0.020512240007519722,
-0.024129919707775116,
-0.02763906866312027,
0.00523357605561614,
0.008109631016850471,
-0.01035862136632204,
0.01035259198397398,
0.011944370344281197,
0.012951291166245937,
-0.011311276815831661,
0.008109631016850471,
0.018534576520323753,
0.02650552988052368,
0.005932993721216917,
-0.00857389997690916,
-0.019511349499225616,
-0.009695379994809628,
-0.02920673042535782,
0.002969511551782489,
-0.006439468823373318,
-0.034102655947208405,
-0.009327583014965057,
-0.0029951368924230337,
0.005393356550484896,
0.00029167538741603494,
0.008151836693286896,
0.001667147153057158,
0.018003983423113823,
-0.020114295184612274,
-0.02093430422246456,
-0.02795260027050972,
-0.005535048898309469,
-0.03128086403012276,
0.009110521525144577,
0.0007386094657704234,
0.023177264258265495,
0.012179519981145859,
-0.000038744023186154664,
-0.0019731426145881414,
-0.001125248963944614,
-0.0012179519981145859,
-0.02394903637468815,
0.013059821911156178,
0.010617888532578945,
-0.02259843610227108,
0.025492578744888306,
-0.00893566757440567,
-0.01325276494026184,
-0.03562207892537117,
0.007404183503240347,
-0.008061395026743412,
-0.004817542620003223,
-0.04572746530175209,
-0.0029303201008588076,
-0.021814605221152306,
-0.023394325748085976,
-0.0048446753062307835,
0.022779319435358047,
-0.0018842079443857074,
0.006349026691168547,
-0.04536569491028786,
0.00611990736797452,
0.0021706074476242065,
0.03205263614654541,
-0.014723953790962696,
-0.01998164691030979,
-0.007217269856482744,
-0.02754259668290615,
-0.033451471477746964,
-0.03123263083398342,
-0.020355474203824997,
-0.0019550540018826723,
-0.048814550042152405,
-0.00467886496335268,
0.008145807310938835,
0.00420253723859787,
-0.0026092510670423508,
0.017304565757513046,
-0.013747180812060833,
-0.026843179017305374,
-0.0076935975812375546,
-0.010871125385165215,
0.016436321660876274,
0.061741724610328674,
-0.021681956946849823,
0.007054474204778671,
-0.003198631340637803,
0.024250509217381477,
-0.022875791415572166,
-0.0032438524067401886,
0.04078330472111702,
-0.015146017074584961,
-0.014844543300569057,
0.025781992822885513,
0.005019529722630978,
-0.048066895455121994,
0.016882503405213356,
-0.022357257083058357,
-0.0009081882308237255,
0.025661403313279152,
-0.0198731180280447,
0.008362867869436741,
-0.0032287787180393934,
0.012269961647689342,
-0.00044052780140191317,
0.018980756402015686,
-0.025926699861884117,
0.01986105926334858,
-0.014422480948269367,
-0.0010295312386006117,
0.011974518187344074,
-0.014989250339567661,
0.006807266268879175,
0.022972263395786285,
0.018739577382802963,
0.011522307991981506,
0.019306348636746407,
0.0022550199646502733,
-0.005016515031456947,
-0.001605345169082284,
-0.03752738982439041,
-0.021730192005634308,
0.03475383669137955,
-0.02427462674677372,
-0.004892910830676556,
0.019945470616221428,
0.0015133958077058196,
-0.008139777928590775,
0.03649032488465309,
0.012987468391656876,
0.005688800476491451,
-0.008700517937541008,
-0.0007725252071395516,
0.00520342867821455,
-0.012963349930942059,
-0.014470716938376427,
0.15252135694026947,
-0.021814605221152306,
0.0030644757207483053,
-0.005513946060091257,
0.0009978765156120062,
-0.01508572231978178,
0.006734912749379873,
-0.005758139304816723,
0.033282648772001266,
-0.005932993721216917,
0.018462222069501877,
0.0062646144069731236,
0.03308970481157303,
0.01214334275573492,
0.027566714212298393,
-0.02468463033437729,
-0.0001521497906651348,
0.040300946682691574,
-0.01272217184305191,
-0.02027106285095215,
-0.0009579312754794955,
0.014567187987267971,
-0.0019490246195346117,
0.025203164666891098,
-0.05141928046941757,
-0.035477373749017715,
-0.01308393944054842,
-0.004151287022978067,
0.000852415629196912,
-0.004880852065980434,
0.013795416802167892,
0.009315524250268936,
0.005848581437021494,
-0.024744926020503044,
0.008435222320258617,
-0.04184448719024658,
-0.007970953360199928,
-0.0033373089972883463,
-0.009610967710614204,
0.013903946615755558,
-0.0031534102745354176,
0.009128610603511333,
-0.009701409377157688,
-0.0006817064131610096,
0.03586325794458389,
0.03656267747282982,
-0.0262884683907032,
-0.008471398614346981,
0.002936349483206868,
-0.018112514168024063,
-0.013120116665959358,
0.006077700760215521,
0.021995488554239273,
-0.016014259308576584,
-0.03422324359416962,
-0.026143761351704597,
0.013385413214564323,
-0.019897235557436943,
-0.011805692687630653,
-0.020970480516552925,
-0.006288732402026653,
0.020439887419342995,
0.020669007673859596,
-0.0059540970250964165,
-0.0003768415772356093
] | 2024-07-16 | 138 | 39012374 | [
"immune cells",
"chimeric antigen receptor T cells",
"unique toxicities",
"toxicity management",
"several emerging agents",
"cytokine release syndrome",
"immune effector cell-associated neurotoxicity syndrome",
"HLH)-like syndrome",
"immune effector cell-associated hemophagocytic lymphohistiocytosis",
"targeted treatment approaches",
"remarkable outcomes",
"cytokine storm",
"underlying biology",
"cancer immunotherapeutics",
"multiple diseases",
"risk factors",
"CAR-T-associated toxicities",
"preclinical models",
"CAR-T",
"particular interest",
"promise",
"patients",
"the anti-tumor function",
"additional and wider CAR-T applications",
"regard",
"hyperinflammation",
"CRS",
"ICANS",
"these toxicities",
"malignancies"
] | [
"CAR-T toxicity",
"Chimeric antigen receptor T cells (CAR-T)",
"cytokine release syndrome (CRS)",
"immune effector cell-assocaited HLH-like syndrome (IEC-HS)",
"immune effector cell-associated neurotoxicity (ICANS)"
] | 0 | 10.1007/s00281-024-01013-w
10.1056/NEJMoa1103849
10.1182/blood-2011-04-348540
10.1056/NEJMoa1215134
10.1038/s41571-023-00754-1
10.1038/s41577-021-00547-6
10.1016/j.jtct.2023.03.006
10.1016/j.bbmt.2018.12.758
10.1200/JCO.21.01992
10.1038/mt.2009.83
10.1097/CJI.0b013e3181ac6138
10.1056/NEJMoa1707447
10.1056/NEJMoa1804980
10.1056/NEJMoa1914347
10.1016/S0140-6736(21)01222-8
10.1038/s41591-022-01969-y
10.1016/S1470-2045(21)00591-X
10.1186/s40364-018-0116-0
10.1182/blood-2013-02-485623
10.1056/NEJMoa1407222
10.1158/2159-8290.CD-16-0040
10.1126/scitranslmed.3008226
10.1158/1078-0432.CCR-22-0822
10.1097/CCM.0000000000002053
10.1182/bloodadvances.2022008256
10.1158/2159-8290.CD-17-1319
10.1158/2159-8290.CD-17-0698
10.1038/nrclinonc.2017.148
10.1182/bloodadvances.2022008937
10.1056/NEJMoa1709919
10.1182/bloodadvances.2020002394
10.1182/blood.2020007445
10.1038/s41408-022-00629-1
10.1016/j.ejca.2021.10.022
10.1182/blood.2019004162
10.3324/haematol.2019.243246
10.3324/haematol.2021.278288
10.1007/s00277-018-3368-8
10.1038/s41591-019-0421-7
10.1038/s41591-019-0737-3
10.1038/s41591-019-0549-5
10.1016/j.cell.2020.08.022
10.1038/s41591-021-01564-7
10.1186/s12929-023-00982-8
10.4049/jimmunol.2001249
10.3389/fimmu.2023.1273507
10.1182/bloodadvances.2020003885
10.1182/bloodadvances.2022007456
10.1080/1744666X.2019.1629904
10.1182/blood.2019001463
10.1111/bjh.17673
10.1038/s41591-018-0041-7
10.1182/bloodadvances.2022006983
10.1016/j.coi.2021.07.002
10.1182/bloodadvances.2023010712
10.1158/2643-3230.BCD-21-0181
10.1182/blood-2022-169809
10.1182/bloodadvances.2018028720
10.1182/blood.2019002936
10.1097/MD.0000000000025786
10.1111/jcmm.16176
10.1186/s40164-021-00209-2
10.1200/JCO.20.02477
10.1016/j.jtct.2021.03.004
10.1038/s41591-023-02404-6
10.1182/blood-2022-167688
10.1016/j.jcrc.2020.04.008
10.3389/fimmu.2021.745320
10.1182/blood.2020008865
10.1111/bjh.17527
10.1038/s41591-018-0036-4
10.1172/JCI130059
10.1158/2643-3230.BCD-21-0203
10.1038/s41392-021-00791-1
10.1111/bjh.16462
10.1111/imj.12921
10.1136/ard-2022-223739
10.1056/NEJMoa2116133
10.1182/blood-2018-10-881722
10.1056/NEJMoa1106152
10.1038/s41571-021-00474-4
10.1016/j.jcrc.2020.02.010
10.1097/CCE.0000000000000472
10.1097/CCM.0b013e3182a66b76
10.1001/jamaneurol.2020.2703
10.1002/ana.25315
10.1126/scitranslmed.aaf8621
10.1182/blood-2021-150431
10.1182/bloodadvances.2020001626
10.1001/jamaoncol.2022.0070
10.1182/bloodadvances.2023009961
10.1056/NEJMoa1709866
10.1182/blood-2018-05-846428
10.1182/bloodadvances.2020002328
10.1182/blood.2023021860
10.1182/blood.2023020571
10.1111/bjh.17662
10.1002/ccr3.5209
10.1111/bjh.18454
10.1182/blood.2019000936
10.1182/blood.2018894618
10.1016/j.coi.2017.08.004
10.1182/blood-2015-01-551622
10.1182/blood.2021011898
10.1002/pbc.29102
10.1186/s12969-021-00585-3
10.1136/annrheumdis-2015-209020
10.1182/blood.V78.11.2918.2918
10.1016/j.jpeds.2011.11.046
10.1182/blood-2003-10-3413
10.1007/s40265-018-1046-8
10.1182/blood.2019002289
10.1056/NEJMoa1911326
10.1182/blood-2021-147596
10.1002/eji.200636420
10.1007/s10875-022-01236-2
10.1002/ajh.20462
10.1016/j.immuni.2012.03.014
10.3324/haematol.2019.222471
10.1111/bjh.17331
10.1097/RHU.0b013e31824e8d9b
10.3109/s10165-011-0500-1
10.2169/internalmedicine.51.5687
10.1186/s10020-021-00308-0
10.4049/jimmunol.1302282 | [
"Hughes",
"Teachey",
"Diorio"
] | [
"Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.",
"Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.\nImmune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.",
"Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [email protected].\nImmune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [email protected]."
] | [
"39012374",
"21830940",
"21849486",
"23527958",
"37055515",
"34002066",
"36906275",
"30592986",
"34724386",
"19384291",
"19561539",
"29226797",
"30501490",
"32242358",
"34097852",
"36138152",
"34895487",
"29387417",
"23678006",
"25317870",
"27076371",
"24553386",
"35705524",
"27632680",
"35917457",
"29880584",
"29025771",
"28925994",
"36508286",
"29385376",
"33035333",
"33512407",
"35210399",
"37861736",
"34865943",
"32181801",
"32079691",
"34233446",
"29766234",
"31011207",
"31959992",
"31477906",
"32961131",
"34893771",
"37864230",
"33692146",
"37854590",
"34432870",
"36399526",
"31219357",
"33335028",
"31697826",
"32029707",
"34590303",
"29808005",
"35395068",
"34672243",
"34389174",
"37721859",
"35015685",
"31270272",
"30814055",
"33795428",
"32076701",
"27677739",
"34106613",
"33314568",
"33608054",
"33417474",
"33831353",
"37400640",
"32361219",
"34712233",
"33534891",
"34296427",
"29808007",
"32925169",
"35015687",
"34824210",
"32017044",
"26648193",
"37001971",
"38014905",
"34891224",
"30463995",
"22047558",
"36989488",
"33608690",
"32113143",
"34235458",
"24145848",
"32777012",
"30178481",
"27605551",
"34996813",
"32407473",
"35266965",
"33067318",
"37399456",
"29385370",
"29954750",
"32645136",
"36877916",
"37796518",
"37471607",
"34263927",
"35028140",
"36111395",
"32107531",
"30992265",
"28866302",
"25758828",
"34525183",
"34114322",
"34187503",
"27296321",
"1954380",
"22226576",
"15069016",
"30623346",
"31537529",
"32374962",
"17274000",
"32321563",
"21080519",
"22522603",
"27786410",
"32653009",
"35304666",
"16369976",
"22520847",
"31515353",
"33559893",
"22426581",
"21773824",
"22449679",
"33975537",
"24259502"
] | [] | 6.185675 | 4.046178 |
39009446 | 724 | Immunotherapies for Childhood Cancer. | Children are surviving cancer in greater numbers than ever. Over the last 50 years, substantial advancements in pediatric cancer treatment have resulted in an 85% 5-year survival rate. Nonetheless, a notable 10%-15% of patients encounter relapse or develop refractory disease, leading to significantly lower survival. Recent attempts to further intensify cytotoxic chemotherapy have failed due to either severe toxicities or ineffectiveness, highlighting the need for new treatment strategies. Immunotherapies are emerging and expanding their clinical application to a wide array of cancers, including those affecting children. In pediatric cancers, monoclonal antibodies targeting GD2 have demonstrated durable radiographic and histologic responses in neuroblastoma (NB), and CD19-targeted bispecific antibodies (BsAbs) and chimeric antigen receptor (CAR) T cells have likewise changed the outlook for refractory acute lymphoblastic leukemia (ALL) in children. This review discusses the clinical development of immunotherapies for pediatric cancers, focusing on pediatric ALL and NB, two major pediatric cancers transformed by immunotherapy, updates on the recent advancements in immunotherapies, and further discusses the future directions of immunotherapy for pediatric cancers. | [
0.0020156875252723694,
0.031053168699145317,
0.06540601700544357,
0.05794783681631088,
-0.02119932509958744,
-0.017730139195919037,
-0.005534312222152948,
0.04436489939689636,
0.0112833296880126,
0.021854741498827934,
0.01385414320975542,
-0.05288530886173248,
-0.02755008265376091,
0.03259000554680824,
0.02755008265376091,
-0.016645312309265137,
0.04567573219537735,
-0.01331172976642847,
0.022419756278395653,
0.01719902642071247,
0.046511951833963394,
-0.00230384455062449,
0.02354978397488594,
0.000405750673962757,
-0.01575258933007717,
-0.048862408846616745,
0.025516031309962273,
-0.008526061661541462,
0.002080664038658142,
-0.006153002381324768,
0.011175977066159248,
-0.0028829840011894703,
-0.04074880853295326,
-0.009531785733997822,
-0.024227799847722054,
-0.0024705238174647093,
0.0020312252454459667,
0.02075861394405365,
-0.015187576413154602,
0.003260130761191249,
0.047009166330099106,
-0.014814667403697968,
0.0019281102577224374,
0.05171008035540581,
-0.052297696471214294,
0.02027270197868347,
0.0035680634900927544,
-0.08081959933042526,
-0.009893395006656647,
-0.02700766921043396,
-0.022634461522102356,
0.04120082035660744,
-0.011130775325000286,
0.00942443311214447,
-0.03588968887925148,
0.06554162502288818,
-0.02357238344848156,
0.0015424882294610143,
-0.027052870020270348,
-0.03733612596988678,
0.021063722670078278,
-0.0013447332894429564,
0.0180465467274189,
-0.020894218236207962,
-0.043438274413347244,
0.01069006510078907,
-0.042511653155088425,
-0.047009166330099106,
0.0020269877277314663,
-0.002751618158072233,
0.013921945355832577,
0.013560336083173752,
0.008350906893610954,
0.014023647643625736,
0.008181402459740639,
0.012091299518942833,
0.016023796051740646,
0.0002445451100356877,
0.0038816460873931646,
-0.01701822131872177,
0.016645312309265137,
-0.02357238344848156,
0.009384882636368275,
-0.020340504124760628,
-0.00034642420359887183,
0.04203703999519348,
0.02558383345603943,
-0.016543610021471977,
-0.03636430203914642,
-0.020159699022769928,
0.013752440921962261,
0.0021527032367885113,
-0.05003764107823372,
0.05514536798000336,
-0.012102600187063217,
-0.002264293609187007,
0.005819644313305616,
-0.02411479689180851,
0.056456197053194046,
0.024182599037885666,
0.03530207276344299,
0.015594386495649815,
-0.02863490954041481,
-0.013673339039087296,
0.01613679900765419,
0.0014252477558329701,
-0.030013544484972954,
0.0010558698559179902,
0.02427300065755844,
-0.006113451439887285,
0.0040991767309606075,
-0.007802843116223812,
-0.011673188768327236,
0.04581133648753166,
-0.042330849915742874,
-0.06269395351409912,
-0.03731352463364601,
-0.022498857229948044,
0.002836370375007391,
0.0815880224108696,
-0.03530207276344299,
0.04678316041827202,
-0.002004387089982629,
-0.021911242976784706,
0.00766158988699317,
-0.02182084135711193,
0.05613978952169418,
-0.023301176726818085,
-0.00435625808313489,
-0.042692456394433975,
0.027617884799838066,
-0.009034574031829834,
0.010243703611195087,
-0.022340653464198112,
-0.07539546489715576,
0.0011272028787061572,
-0.017266828566789627,
-0.028408903628587723,
-0.029651934280991554,
0.008130551315844059,
0.03304201737046242,
0.0007218053797259927,
-0.03385563939809799,
0.008865069597959518,
-0.01670181378722191,
-0.017447631806135178,
0.015707388520240784,
0.019425181671977043,
0.03322282433509827,
0.01923307590186596,
-0.036341700702905655,
0.042308248579502106,
0.021707838401198387,
0.00040681008249521255,
-0.028408903628587723,
-0.02538042888045311,
0.012701515108346939,
0.0682084932923317,
-0.02773088775575161,
-0.04108781740069389,
-0.0342850498855114,
0.04696396365761757,
-0.02037440426647663,
-0.0364547036588192,
0.0049382224678993225,
-0.0014139475533738732,
-0.012249503284692764,
0.006356407422572374,
-0.03948317840695381,
0.013978445902466774,
0.010836968198418617,
-0.020001495257019997,
-0.02901911921799183,
0.0025581009685993195,
-0.012690214440226555,
-0.0020340504124760628,
0.018272552639245987,
0.010192852467298508,
-0.039437975734472275,
0.003322282340377569,
0.0193121787160635,
0.03148258104920387,
0.019741589203476906,
-0.005361982621252537,
-0.03593489155173302,
0.04515592008829117,
-0.048862408846616745,
-0.003361833281815052,
-0.06879610568284988,
-0.017255527898669243,
-0.01100082229822874,
-0.03209279477596283,
0.011401982046663761,
0.0015834517544135451,
-0.002819419838488102,
-0.00019069222616963089,
0.0332002229988575,
-0.0008482272387482226,
-0.044477902352809906,
-0.04655715450644493,
0.016408005729317665,
-0.028499305248260498,
-0.03521167114377022,
-0.03457885608077049,
-0.04273765906691551,
-0.02974233776330948,
0.00022300396813079715,
0.013481234200298786,
0.004166978411376476,
-0.03808194398880005,
0.003133002668619156,
0.01533447951078415,
-0.029493730515241623,
0.005008849315345287,
-0.02522222511470318,
-0.01832905411720276,
-0.040500205010175705,
0.010153301991522312,
0.01740243099629879,
-0.00006502075120806694,
0.02429560199379921,
0.01810304820537567,
-0.013650738634169102,
0.011136425659060478,
-0.0227474644780159,
0.009418783709406853,
-0.008593862876296043,
-0.02375318855047226,
-0.029832739382982254,
-0.014385255984961987,
-0.0054297843016684055,
0.03207019343972206,
0.029990943148732185,
-0.006339456886053085,
-0.03421724587678909,
-0.00009993684943765402,
0.001550963381305337,
0.024318203330039978,
0.04389028623700142,
-0.024702411144971848,
0.014995471574366093,
0.03548287972807884,
-0.019843291491270065,
-0.0021442282013595104,
-0.04872680827975273,
0.01154323574155569,
-0.008057099767029285,
-0.06725926697254181,
0.018080448731780052,
0.0030595508869737387,
-0.04425189644098282,
-0.0030256500467658043,
-0.002377296332269907,
-0.021549634635448456,
0.029064320027828217,
-0.02138013020157814,
0.05261410400271416,
-0.019063571467995644,
-0.012351205572485924,
0.02662345953285694,
-0.007881944999098778,
0.0017444806871935725,
-0.007944096811115742,
-0.0700165331363678,
-0.06404998898506165,
0.03683891147375107,
-0.011486734263598919,
0.03503086790442467,
0.04203703999519348,
-0.021696537733078003,
0.019504282623529434,
0.004864770453423262,
0.029041718691587448,
-0.028386304154992104,
-0.030375152826309204,
0.00724347960203886,
0.006153002381324768,
0.02827330119907856,
-0.01810304820537567,
0.041585031896829605,
-0.024612009525299072,
-0.02992314100265503,
0.009769092313945293,
-0.06323636323213577,
-0.01487116888165474,
0.01670181378722191,
-0.014362655580043793,
0.010379306972026825,
-0.009802992455661297,
-0.024431204423308372,
-0.013537735678255558,
-0.005698166321963072,
-0.004986248444765806,
-0.034895263612270355,
0.0046557155437767506,
-0.0003529571695253253,
0.020306603983044624,
0.003912721760571003,
-0.03062375821173191,
0.03299681842327118,
-0.03769773244857788,
0.004771543201059103,
-0.02755008265376091,
-0.024905817583203316,
0.05690820887684822,
0.0171425249427557,
0.023617584258317947,
0.016645312309265137,
0.028928717598319054,
0.04059060662984848,
0.035098668187856674,
-0.014464358799159527,
0.009130625985562801,
0.012882319279015064,
0.002548213116824627,
0.00832830648869276,
0.01662271097302437,
-0.05763142928481102,
-0.0017035171622410417,
0.0006211622385308146,
0.000038646074244752526,
-0.018216051161289215,
-0.04185623675584793,
0.019120072945952415,
-0.056094590574502945,
-0.03828534856438637,
-0.004853470250964165,
-0.02132362872362137,
0.05171008035540581,
-0.07417503744363785,
0.004836519714444876,
-0.03473706170916557,
0.06282955408096313,
0.009339681826531887,
0.009475285187363625,
-0.02284916676580906,
0.030691560357809067,
-0.06938371807336807,
-0.002351870760321617,
0.0009760616812855005,
-0.011718390509486198,
0.00026273151161149144,
-0.03647730499505997,
0.011159026063978672,
0.030894964933395386,
-0.04554012790322304,
-0.024227799847722054,
0.05383453518152237,
-0.014712964184582233,
0.07770072668790817,
0.027776088565587997,
0.0009181477362290025,
0.04402589052915573,
0.03704231604933739,
-0.03301941975951195,
0.04567573219537735,
-0.006418559234589338,
-0.0306689590215683,
0.02395659312605858,
0.02078121528029442,
-0.01084261853247881,
-0.010368007235229015,
-0.04210484400391579,
0.06513481587171555,
0.04954042658209801,
0.0696549266576767,
-0.021368829533457756,
0.008887670002877712,
-0.02158353477716446,
-0.018069148063659668,
-0.0379011407494545,
0.028928717598319054,
0.019063571467995644,
0.008746416307985783,
-0.0667620524764061,
0.0180465467274189,
-0.0054947612807154655,
-0.03317762166261673,
-0.006876220460981131,
0.05473855510354042,
0.009848194196820259,
-0.01222690287977457,
0.010718315839767456,
-0.003062375821173191,
-0.023820990696549416,
0.01231730543076992,
-0.010113750584423542,
-0.04183363541960716,
-0.07033294439315796,
0.022916967049241066,
0.0011575723765417933,
-0.014758165925741196,
0.01432875543832779,
-0.00024860617122612894,
-0.00007137715874705464,
0.06328156590461731,
-0.047189969569444656,
0.06477320194244385,
0.04135902598500252,
0.03656770661473274,
-0.0003891533997375518,
-0.0736326277256012,
-0.02391139231622219,
-0.06508961319923401,
0.014792066067457199,
-0.029855338856577873,
0.006565462797880173,
0.007102225907146931,
0.06988093256950378,
-0.05243330076336861,
-0.036703310906887054,
0.04673795774579048,
0.028160298243165016,
-0.021244525909423828,
0.017571935430169106,
-0.041946638375520706,
-0.02992314100265503,
0.04038720205426216,
-0.043799884617328644,
0.06513481587171555,
0.009345331229269505,
-0.037968941032886505,
0.00652591185644269,
-0.032906416803598404,
0.00897242221981287,
0.0028519080951809883,
0.04190143942832947,
0.011627987958490849,
0.001623002695851028,
-0.021933844313025475,
-0.04280545935034752,
0.05763142928481102,
-0.021357528865337372,
-0.05256890133023262,
0.019357379525899887,
0.01569608971476555,
-0.027956891804933548,
0.03878255933523178,
-0.03699711710214615,
-0.011831393465399742,
0.0021583535708487034,
0.013040523044764996,
-0.027233675122261047,
-0.018475957214832306,
-0.01910877414047718,
0.0022275676019489765,
-0.02091681770980358,
0.06359797716140747,
-0.014905069023370743,
-0.04841040074825287,
0.02879311330616474,
-0.017006920650601387,
0.012441608123481274,
0.010362356901168823,
-0.038714759051799774,
0.003686716314405203,
0.028680110350251198,
-0.06594843417406082,
0.004373208153992891,
0.018600260838866234,
0.041969239711761475,
-0.007209578529000282,
-0.013989746570587158,
-0.06070510298013687,
0.023063872009515762,
0.008305706083774567,
0.05419614166021347,
-0.038692157715559006,
-0.005932646803557873,
-0.04637634754180908,
0.021888641640543938,
-0.03794633969664574,
-0.03649990260601044,
-0.010627913288772106,
0.0037206171546131372,
0.0685700997710228,
-0.007949747145175934,
0.01487116888165474,
0.034917864948511124,
0.022815264761447906,
-0.0049410476349294186,
0.012102600187063217,
-0.02571943774819374,
-0.04147202894091606,
0.02608104608952999,
-0.0213010273873806,
-0.04967603087425232,
0.01941388100385666,
-0.018091747537255287,
0.020261401310563087,
-0.0054778107441961765,
0.004166978411376476,
0.012780616991221905,
-0.009079774841666222,
-0.02073601447045803,
-0.009350981563329697,
0.005138802342116833,
-0.003974873572587967,
-0.03973178565502167,
0.007096576038748026,
0.013662038370966911,
-0.0011568662011995912,
0.013176126405596733,
0.01662271097302437,
0.06142832338809967,
0.009887744672596455,
0.04237604886293411,
0.040500205010175705,
-0.006921421270817518,
0.01359423715621233,
-0.03166338428854942,
-0.021990343928337097,
0.040681008249521255,
-0.011068624444305897,
-0.04526892304420471,
-0.02935812808573246,
-0.04764198139309883,
-0.030420353636145592,
0.015549184754490852,
-0.0060456497594714165,
-0.013108325190842152,
0.010983872227370739,
0.014520859345793724,
0.0016399531159549952,
0.018555060029029846,
-0.022498857229948044,
-0.03403644263744354,
-0.01522147748619318,
-0.009718241170048714,
-0.02013709954917431,
0.010763516649603844,
-0.01675831526517868,
0.000008331749086210039,
0.03731352463364601,
-0.04655715450644493,
-0.006842319387942553,
-0.03243180364370346,
0.026555657386779785,
-0.04587913677096367,
-0.021063722670078278,
-0.009712590835988522,
0.007582488004118204,
0.02847670577466488,
0.015153675340116024,
0.017797941341996193,
0.04244385287165642,
0.006898820865899324,
-0.017571935430169106,
-0.009560036472976208,
-0.013842842541635036,
0.03064635954797268,
-0.017877042293548584,
-0.01719902642071247,
0.010322805494070053,
-0.005949597340077162,
-0.013842842541635036,
-0.007283030543476343,
-0.01652100868523121,
0.012758015654981136,
-0.012385106645524502,
-0.014159251004457474,
-0.0213010273873806,
0.023640185594558716,
-0.022092048078775406,
0.0028886341024190187,
0.029855338856577873,
0.0023292701225727797,
0.002447923179715872,
-0.032725609838962555,
0.018091747537255287,
-0.03620609641075134,
0.013130925595760345,
0.020159699022769928,
-0.03656770661473274,
0.010859568603336811,
0.00111025245860219,
-0.035980090498924255,
0.04000299051403999,
-0.03220579773187637,
-0.007514686323702335,
-0.011514985002577305,
-0.02499621920287609,
-0.028024693951010704,
0.045042917132377625,
0.0014746865490451455,
0.010577062144875526,
-0.04144942760467529,
0.00313017750158906,
0.01142458338290453,
-0.011492384597659111,
0.044342298060655594,
-0.02806989476084709,
0.010418858379125595,
0.00321775465272367,
-0.03930237516760826,
0.015989895910024643,
0.003658465575426817,
-0.008418708108365536,
-0.03281601145863533,
-0.0035821888595819473,
0.009096724912524223,
0.007057024631649256,
-0.0036132645327597857,
-0.028612308204174042,
-0.018961869180202484,
0.03686151280999184,
0.002906996989622712,
-0.02775348722934723,
-0.005065350327640772,
-0.014012346975505352,
0.013560336083173752,
0.029968341812491417,
-0.01709732413291931,
0.0015114124398678541,
0.024951018393039703,
0.005339382216334343,
0.005655790213495493,
0.005768792703747749,
0.03372003510594368,
0.0003930378588847816,
-0.014034947380423546,
-0.005932646803557873,
-0.024702411144971848,
-0.009300130419433117,
-0.006475060246884823,
-0.03864695876836777,
0.01513107493519783,
-0.014227052219212055,
0.00907412450760603,
-0.02897391840815544,
0.00887071993201971,
-0.047415975481271744,
-0.025787238031625748,
0.023165574297308922,
-0.01138503197580576,
-0.05903266370296478,
0.0458565354347229,
-0.004169803112745285,
0.007000523619353771,
0.01487116888165474,
-0.02825069986283779,
0.01039060764014721,
-0.015650887042284012,
-0.04637634754180908,
-0.012950120493769646,
-0.01933477818965912,
-0.02045350708067417,
0.005401534028351307,
0.013436032459139824,
-0.027324076741933823,
-0.02811509743332863,
-0.020363103598356247,
0.00606825016438961,
0.0005123970913700759,
0.013820242136716843,
-0.024408604949712753,
-0.0006518848822452128,
-0.007480785250663757,
0.027979493141174316,
0.05962027609348297,
-0.00902327336370945,
0.005104901269078255,
0.013458633795380592,
-0.017131224274635315,
0.010938671417534351,
-0.0007677127723582089,
0.013899344019591808,
-0.004534237552434206,
-0.000498978013638407,
-0.006395958364009857,
0.06730446964502335,
0.015503983944654465,
0.033268023282289505,
-0.008797268383204937,
-0.017730139195919037,
0.007638989482074976,
0.014407857321202755,
-0.005700991023331881,
-0.03446585312485695,
0.010526211000978947,
-0.017153825610876083,
0.026894666254520416,
-0.03683891147375107,
-0.05677260830998421,
0.02409219741821289,
0.007825443521142006,
-0.00011468018783489242,
0.01285971887409687,
-0.0016145275440067053,
-0.03324542194604874,
-0.0054297843016684055,
-0.020080598071217537,
-0.019018370658159256,
-0.011605387553572655,
0.002306669717654586,
0.026939867064356804,
0.009226678870618343,
0.009181477129459381,
-0.023662786930799484,
-0.04945002496242523,
0.031030569225549698,
-0.007825443521142006,
0.05369893088936806,
-0.03062375821173191,
0.005288531072437763,
-0.0009633488953113556,
0.003777118632569909,
0.0032290550880134106,
0.006531561724841595,
0.014803366735577583,
-0.004469260573387146,
0.013119624927639961,
-0.020894218236207962,
-0.016023796051740646,
0.012441608123481274,
0.004853470250964165,
-0.011989597231149673,
0.04673795774579048,
0.004534237552434206,
0.022510157898068428,
-0.010294554755091667,
-0.009673039428889751,
0.003590663895010948,
0.009158876724541187,
0.011831393465399742,
0.05035404860973358,
-0.04219524562358856,
0.04273765906691551,
-0.02538042888045311,
-0.0015778015367686749,
-0.022148549556732178,
-0.003842095145955682,
-0.037765536457300186,
-0.02919992431998253,
-0.03243180364370346,
0.029132122173905373,
-0.01241900771856308,
-0.02522222511470318,
-0.004585088696330786,
0.006554162595421076,
0.030194347724318504,
-0.05220729485154152,
-0.02447640709578991,
-0.004780018236488104,
-0.002066538669168949,
0.007006173487752676,
0.00606825016438961,
0.012068699114024639,
0.01631760410964489,
-0.00818705279380083,
0.026420054957270622,
0.006864920258522034,
-0.010735265910625458,
-0.006367707625031471,
-0.0069327219389379025,
-0.013899344019591808,
-0.002806707052513957,
-0.006831019185483456,
-0.03602529317140579,
-0.02200164459645748,
0.0009301542886532843,
0.003271430963650346,
-0.005308306310325861,
-0.009096724912524223,
0.002277006395161152,
0.005147277377545834,
0.02375318855047226,
0.00711917644366622,
-0.018905367702245712,
-0.0009223853703588247,
-0.034375451505184174,
-0.02974233776330948,
0.028160298243165016,
-0.04036460071802139,
-0.005285705905407667,
0.0400707945227623,
-0.03555068001151085,
-0.016068998724222183,
0.005627539474517107,
-0.002832132624462247,
-0.0004894433659501374,
-0.007565537467598915,
0.01864546164870262,
0.038330551236867905,
-0.0028151823207736015,
-0.01523277722299099,
0.009158876724541187,
0.031120970845222473,
-0.026872064918279648,
-0.010221103206276894,
-0.015888193622231483,
0.005054050125181675,
-0.021786939352750778,
0.027663085609674454,
0.01763973757624626,
0.023504583165049553,
0.033629633486270905,
-0.07932796329259872,
-0.01039060764014721,
-0.018939269706606865,
-0.022657060995697975,
-0.010825668461620808,
0.009610888548195362,
-0.05397013574838638,
-0.012034798040986061,
0.010921720415353775,
-0.005319606978446245,
0.013085723854601383,
-0.04074880853295326,
-0.010531861335039139,
0.014803366735577583,
0.0003803250438068062,
-0.00729433074593544,
-0.021719137206673622,
-0.07173417508602142,
-0.029674535617232323,
0.003545462852343917,
-0.0014266603393480182,
0.010396257974207401,
0.005234854761511087,
0.0025807013735175133,
-0.003531337482854724,
0.019379980862140656,
0.006718016229569912,
-0.006497661117464304,
-0.0346466600894928,
-0.025855040177702904,
0.006147352512925863,
0.013808942399919033,
-0.021357528865337372,
0.0429636649787426,
0.00887071993201971,
-0.03769773244857788,
0.02019360102713108,
-0.0012317305663600564,
0.0015170625410974026,
0.004359082784503698,
0.006237754598259926,
0.015628287568688393,
0.022137248888611794,
-0.004339307546615601,
-0.04492991417646408,
-0.012814517132937908,
-0.03026214987039566,
0.0074581848457455635,
0.04881720989942551,
-0.010605312883853912,
-0.001635715481825173,
-0.04199184104800224,
-0.04108781740069389,
-0.017413731664419174,
-0.000569251598790288,
-0.02164003625512123,
0.0029973993077874184,
0.007051374763250351,
0.03475965932011604,
-0.00023730588145554066,
-0.022419756278395653,
0.04782278463244438,
0.007915846072137356,
-0.019379980862140656,
-0.01541358232498169,
-0.02992314100265503,
-0.025674236938357353,
0.015210176818072796,
-0.00961653795093298,
0.009017623029649258,
0.00643550930544734,
0.02427300065755844,
-0.057224616408348083,
0.01923307590186596,
0.007932796142995358,
-0.0029663234017789364,
0.022815264761447906,
0.005876145791262388,
-0.007548586931079626,
0.0360930934548378,
-0.028521906584501266,
-0.009339681826531887,
-0.01967378705739975,
0.03209279477596283,
-0.02680426463484764,
-0.016204601153731346,
-0.009633488953113556,
0.031459979712963104,
0.012927520088851452,
0.01222690287977457,
-0.03756213188171387,
-0.018905367702245712,
0.041042618453502655,
0.026171447709202766,
-0.019990194588899612,
-0.012181702069938183,
-0.006006098818033934,
-0.01818215101957321,
-0.00489867152646184,
-0.026736462488770485,
0.021606136113405228,
-0.02037440426647663,
-0.005926996935158968,
-0.05293051153421402,
0.01359423715621233,
-0.025064021348953247,
0.013921945355832577,
0.0065880632027983665,
-0.017594536766409874,
-0.010565761476755142,
0.04472650960087776,
-0.014701664447784424,
0.06970012933015823,
-0.006085200700908899,
0.00995554681867361,
0.0020170998759567738,
0.025606434792280197,
-0.017571935430169106,
0.01647580787539482,
-0.0031273525673896074,
0.059529874473810196,
-0.0018603085773065686,
0.008215303532779217,
0.01918787509202957,
-0.02101851999759674,
0.005014499183744192,
0.002977623837068677,
0.000684020051266998,
-0.004522936884313822,
0.007684190291911364,
0.004825219511985779,
-0.00453141238540411,
-0.0010735265677794814,
0.007051374763250351,
0.012825817801058292,
0.0013743964955210686,
-0.0033929089549928904,
0.01810304820537567,
0.031437378376722336,
-0.0019860242027789354,
-0.010102449916303158,
-0.02049870789051056,
-0.02266836166381836,
0.02445380575954914,
0.043799884617328644,
-0.012452908791601658,
-0.030375152826309204,
0.01987719163298607,
0.04526892304420471,
0.00008201531454687938,
0.012837118469178677,
0.017718838527798653,
0.04999243840575218,
0.03794633969664574,
0.012565911747515202,
0.04201444238424301,
0.019165275618433952,
-0.018012646585702896,
-0.04264725744724274,
0.02811509743332863,
-0.024137398228049278,
0.03419464826583862,
-0.027098070830106735,
-0.02770828641951084,
-0.031075770035386086,
-0.0006674227770417929,
-0.008887670002877712,
-0.002477586269378662,
0.023120373487472534,
0.00823790393769741,
0.018193449825048447,
-0.011113825254142284,
0.02809249609708786,
-0.01394454576075077,
-0.008746416307985783,
0.014362655580043793,
0.008373507298529148,
0.03584448620676994,
0.04219524562358856,
0.0223858542740345,
-0.0007168615120463073,
0.012272103689610958,
0.034556254744529724,
0.0397091843187809,
0.04499771445989609,
-0.019040971994400024,
-0.03591229021549225,
-0.007972347550094128,
0.03968658298254013,
-0.023323778063058853,
-0.0038392702117562294,
-0.028499305248260498,
0.005977848079055548,
0.0635075718164444,
0.04300886392593384,
-0.03602529317140579,
-0.04239865019917488,
0.005305481608957052,
-0.030578557401895523,
-0.026352252811193466,
-0.04228564724326134,
0.03297421708703041,
0.052659302949905396,
-0.009882095269858837,
-0.03390083834528923,
0.01084261853247881,
0.0029691485688090324,
-0.05889705941081047,
0.005972197744995356,
0.05943947285413742,
-0.004570963326841593,
0.03082716464996338,
-0.032725609838962555,
0.02086031623184681,
-0.009949896484613419,
0.013888044282793999,
0.0022035546135157347,
0.0002576110709924251,
-0.04011599346995354,
0.0013087136903777719,
-0.03394604101777077,
-0.03982218727469444,
0.002692291745916009,
-0.01487116888165474,
-0.015153675340116024,
0.0021908418275415897,
0.034691859036684036,
0.016351504251360893,
-0.01824995130300522,
0.007627688813954592,
-0.0012507997453212738,
0.04400328919291496,
0.0019168099388480186,
0.014712964184582233,
-0.004573788493871689,
0.012125200591981411,
0.006424209102988243,
-0.018758464604616165,
0.008802917785942554,
-0.012599811889231205,
0.05903266370296478,
-0.0031132271979004145,
-0.01178619172424078,
-0.030691560357809067,
-0.018069148063659668,
0.020261401310563087,
0.0382627472281456,
-0.03713272139430046,
-0.03656770661473274,
-0.03446585312485695,
-0.024137398228049278,
0.029064320027828217,
0.028770511969923973,
0.04108781740069389,
0.030329952016472816,
0.020792515948414803,
0.009961197152733803,
0.011204227805137634,
0.007633339148014784,
0.017538035288453102,
-0.0016131149604916573,
-0.030894964933395386,
-0.00881986878812313,
-0.005576688330620527,
-0.0026273149996995926,
0.029064320027828217,
-0.0024027221370488405,
-0.046331148594617844,
0.04954042658209801,
-0.006678465288132429,
0.0033844339195638895,
0.019040971994400024,
-0.013187427073717117,
-0.00569251598790288,
-0.03387824073433876,
-0.04054540395736694,
-0.0018730213632807136,
-0.016001196578145027,
0.020611710846424103,
-0.021628735587000847,
-0.003517212113365531,
0.011430232785642147,
0.009328381158411503,
0.011339831165969372,
0.027256274595856667,
0.030555957928299904,
-0.0364547036588192,
-0.021357528865337372,
0.010938671417534351,
-0.008243554271757603,
-0.037245724350214005,
0.033607032150030136,
-0.0037064917851239443,
0.0007684190641157329,
0.003051075618714094,
-0.014656462706625462,
-0.001894209417514503,
0.0007214522338472307,
0.01641930639743805,
-0.009028923697769642,
-0.003924022428691387,
0.022318052127957344,
-0.014114049263298512,
0.012701515108346939,
-0.027052870020270348,
-0.005853544920682907,
-0.013808942399919033,
-0.05270450562238693,
0.022657060995697975,
0.0036104393657296896,
-0.030917566269636154,
0.055913783609867096,
0.005898746196180582,
-0.001666791271418333,
0.0005731360870413482,
-0.017775340005755424,
0.007554237265139818,
0.011317230761051178,
0.02504142001271248,
0.0011363844387233257,
0.014057548716664314,
0.025877641513943672,
-0.002291131764650345,
0.0031725536100566387,
-0.014453058131039143,
0.007994947955012321,
0.02610364742577076,
-0.011413282714784145,
-0.018724564462900162,
-0.03295161575078964,
0.012780616991221905,
-0.009486584924161434,
-0.024408604949712753,
-0.035256873816251755,
0.015108474530279636,
0.03430765122175217,
0.009277530014514923,
0.020487407222390175,
0.027233675122261047,
-0.019244376569986343,
-0.007000523619353771,
-0.010763516649603844,
0.00047072727466002107,
0.022295452654361725,
0.04165283218026161,
-0.01657751016318798,
-0.007237829267978668,
-0.01395584549754858,
-0.032183196395635605,
-0.015311879105865955,
0.05523576959967613,
-0.021967744454741478,
-0.05876145511865616,
0.028047295287251472,
0.016441907733678818,
0.010848268866539001,
-0.00010187908628722653,
0.0016272403299808502,
-0.018272552639245987,
-0.004844995215535164,
-0.0007387557998299599,
0.020747313275933266,
0.013277828693389893,
-0.02357238344848156,
-0.007701140828430653,
0.012498109601438046,
-0.001908334787003696,
0.009853844530880451,
-0.008413058705627918,
0.007051374763250351,
-0.00182358268648386,
0.04436489939689636,
-0.03627390041947365,
-0.001751543371938169,
0.005813993979245424,
0.012249503284692764,
0.05835464596748352,
-0.007915846072137356,
-0.0011611037189140916,
0.053744129836559296,
-0.017538035288453102,
0.0021922544110566378,
0.005681215785443783,
-0.009752141311764717,
0.028612308204174042,
-0.006955322343856096,
-0.032341402024030685,
-0.004483385942876339,
0.005695341154932976,
0.017312029376626015,
0.00734518188983202,
0.02956153266131878,
0.033968642354011536,
-0.005757492501288652,
-0.003548288019374013,
-0.007356482092291117,
0.006243404466658831,
0.008311355486512184,
0.006554162595421076,
0.008407408371567726,
-0.018453357741236687,
-0.01467906404286623,
-0.0019733114168047905,
-0.009639138355851173,
0.01541358232498169,
0.035437677055597305,
-0.009808642789721489,
0.010328455828130245,
-0.0072039286606013775,
0.003418334759771824,
-0.02956153266131878,
-0.007853694260120392,
-0.040884412825107574,
0.0009859494166448712,
-0.012950120493769646,
0.012113899923861027,
-0.024566808715462685,
-0.0010382132604718208,
-0.02140272967517376,
-0.0029804487712681293,
-0.0002028753369813785,
-0.011740990914404392,
0.0071756779216229916,
0.006734966766089201,
0.0032008043490350246,
-0.0010233815992251039,
-0.0043816836550831795,
0.021707838401198387,
-0.0054891109466552734,
0.03385563939809799,
0.002097614575177431,
-0.0028956967871636152,
0.0021668286062777042,
0.0043647331185638905,
0.0052376799285411835,
-0.02571943774819374,
0.031979791820049286,
0.000032135172659764066,
-0.01975288987159729,
-0.004260205663740635,
-0.010452758520841599,
0.0106505136936903,
0.03772033378481865,
-0.0003160547057632357,
0.0026541531551629305,
-0.017052123323082924,
-0.016667913645505905,
-0.009921645745635033,
0.009435733780264854,
0.027663085609674454,
0.005602113902568817,
0.0035115620121359825,
-0.04520111903548241,
-0.015119774267077446,
0.01748153381049633,
-0.00797799788415432,
-0.05686300992965698,
-0.004748942796140909,
0.04599213972687721,
0.03299681842327118,
-0.0008242141921073198,
-0.013820242136716843,
-0.008610812947154045,
0.0007200397085398436,
0.003859045682474971,
0.013029222376644611,
-0.028002094477415085,
-0.01231730543076992,
-0.019944993779063225,
-0.001976136351004243,
0.014001047238707542,
-0.009328381158411503,
-0.00015802735288161784,
-0.0019718988332897425,
0.006175602786242962,
-0.01177489198744297,
0.03485006466507912,
0.029267724603414536,
-0.010481009259819984,
-0.003090626560151577,
-0.007525986526161432,
0.0074751353822648525,
-0.031256575137376785,
0.023527182638645172,
0.012984021566808224,
0.004443835001438856,
0.01887146756052971,
-0.005121851805597544,
0.019323479384183884,
0.002491711638867855,
-0.01740243099629879,
-0.014475658535957336,
0.008317005820572376,
0.011514985002577305,
-0.008209653198719025,
0.01892796903848648,
-0.002083489205688238,
-0.029109520837664604,
-0.019142674282193184,
-0.0008934283978305757,
-0.008153151720762253,
0.029584132134914398,
-0.01070136483758688,
-0.029064320027828217,
0.0415172278881073,
0.006356407422572374,
-0.010045948438346386,
-0.06689766049385071,
-0.010746566578745842,
0.005545612424612045,
-0.039596181362867355,
0.012385106645524502,
0.0007316931150853634,
0.025696836411952972,
0.02192254364490509,
0.010729615576565266,
0.002008624840527773,
0.04854600131511688,
0.018374254927039146,
0.018735863268375397,
0.02277006395161152,
0.024340802803635597,
0.007130476646125317,
-0.04967603087425232,
-0.022758763283491135,
-0.005480635911226273,
-0.024024395272135735,
0.020510008558630943,
-0.01879236474633217,
0.016023796051740646,
0.01760583557188511,
-0.007463834714144468,
0.0418788380920887,
-0.007955397479236126,
-0.009961197152733803,
0.009288829751312733,
0.002932422561571002,
-0.012667614035308361,
-0.019357379525899887,
-0.026510456576943398,
-0.012034798040986061,
0.004161328077316284,
0.014215752482414246,
-0.01828385330736637,
0.009079774841666222,
-0.017730139195919037,
0.014882468618452549,
-0.030917566269636154,
-0.0060456497594714165,
-0.006379007827490568,
0.04497511312365532,
-0.002067951252683997,
-0.015345780178904533,
-0.001168166403658688,
-0.011842693202197552,
0.010836968198418617,
0.022600559517741203,
0.01975288987159729,
-0.03062375821173191,
0.030872365459799767,
-0.028228098526597023,
0.018555060029029846,
0.021447930485010147,
0.016441907733678818,
0.012079998850822449,
-0.008130551315844059,
-0.006085200700908899,
-0.03584448620676994,
-0.03315502032637596,
-0.007944096811115742,
0.006203853525221348,
-0.029132122173905373,
-0.011944395489990711,
0.01261111255735159,
-0.015277978964149952,
-0.015537885017693043,
-0.01716512441635132,
0.022657060995697975,
-0.012565911747515202,
-0.009034574031829834,
0.02933552674949169,
-0.018543759360909462,
-0.029064320027828217,
0.011209878139197826,
-0.0040483251214027405,
0.016023796051740646,
-0.016995621845126152,
-0.05058005452156067,
0.00018769058806356043,
0.0024705238174647093,
-0.0342850498855114,
-0.013707239180803299,
-0.03256740793585777,
-0.014464358799159527,
0.026013243943452835,
0.022781364619731903,
-0.010853919200599194,
0.01902967132627964,
-0.058309443295001984,
0.005240504629909992,
-0.004630289506167173,
0.02176433987915516,
-0.012407707050442696,
-0.033426228910684586,
0.011707089841365814,
0.0005498292739503086,
-0.006672815419733524,
-0.03222839906811714,
-0.042669858783483505,
-0.014306154102087021,
-0.02646525576710701,
0.02409219741821289,
0.02264576032757759,
0.0335618332028389,
0.002421085024252534,
0.003994648810476065,
-0.05812864005565643,
0.0002606126945465803,
0.014430457726120949,
0.019786790013313293,
0.010582712478935719,
0.03649990260601044,
0.005706641357392073,
-0.017549334093928337,
-0.003076501190662384,
0.018453357741236687,
-0.026533057913184166,
0.004056800622493029,
0.00038985966239124537,
0.01722162589430809,
-0.022984769195318222,
0.0031669035088270903,
-0.0008764779777266085,
-0.03227359801530838,
-0.005926996935158968,
0.004974948242306709,
-0.041788436472415924,
-0.003491786541417241,
-0.03550548106431961,
0.003474836004897952,
0.017278127372264862,
0.037991542369127274,
-0.014464358799159527,
0.008458259515464306,
-0.018905367702245712,
0.047235168516635895,
-0.01892796903848648,
-0.03697451576590538,
0.0026541531551629305,
-0.022498857229948044,
-0.010187202133238316,
0.014916369691491127,
0.0046331146731972694,
0.02825069986283779,
0.0025114871095865965,
0.05713421478867531,
-0.017775340005755424,
-0.007910195738077164,
-0.02843150496482849,
0.008735116571187973,
0.018035246059298515,
0.008023198693990707,
-0.01722162589430809,
0.02373058721423149,
-0.024747613817453384,
0.013029222376644611,
0.02481541410088539,
0.0028434330597519875,
0.0018998595187440515,
0.0350082665681839,
-0.01613679900765419,
0.00901197362691164,
-0.033968642354011536,
-0.0006758979870937765,
0.08077440410852432,
0.010955621488392353,
-0.020125798881053925,
0.0022586435079574585,
-0.030397752299904823,
-0.010040299035608768,
0.00475741783156991,
0.021707838401198387,
0.02791169099509716,
-0.007260429672896862,
0.017538035288453102,
0.01070136483758688,
0.027482280507683754,
0.028567107394337654,
0.0040511502884328365,
-0.009949896484613419,
-0.01595599576830864,
0.03114357218146324,
-0.007593788206577301,
-0.03566368296742439,
0.010978221893310547,
0.016408005729317665,
0.012916220352053642,
0.031098369508981705,
-0.014667763374745846,
0.009729540906846523,
-0.001824995269998908,
-0.022860465571284294,
-0.02791169099509716,
-0.012238203547894955,
0.01522147748619318,
0.006175602786242962,
0.012102600187063217,
-0.04637634754180908,
0.024792814627289772,
0.004059625789523125,
-0.013741140253841877,
0.00023589334159623832,
-0.02499621920287609,
0.020182300359010696,
0.007079625502228737,
0.00165266590192914,
-0.03136957809329033,
-0.0009442796581424773,
-0.002250168239697814,
0.017108622938394547,
-0.005876145791262388,
0.005650139879435301,
0.002860383363440633,
-0.023640185594558716,
-0.004763068165630102,
-0.02302997000515461,
-0.0020877267234027386,
-0.00040221933159045875,
-0.008384807966649532,
-0.02755008265376091,
0.0014421981759369373,
-0.03274821117520332,
-0.002421085024252534,
-0.008345256559550762,
-0.034895263612270355,
0.02202424593269825,
0.0035878389608114958,
-0.01322132721543312,
0.002021337626501918
] | 2024-07-16 | 1 | 39009446 | [
"pediatric cancer treatment",
"pediatric cancers",
"cancer",
"cancers",
"pediatric ALL",
"refractory acute lymphoblastic leukemia",
"refractory disease",
"new treatment strategies",
"substantial advancements",
"Immunotherapies",
"immunotherapies",
"immunotherapy",
"cytotoxic chemotherapy",
"two major pediatric cancers",
"T cells",
"Recent attempts",
"NB",
"ALL",
"Children",
"children",
"greater numbers",
"ineffectiveness",
"relapse",
"CAR",
"durable radiographic and histologic responses",
"CD19-targeted bispecific",
"GD2",
"patients",
"monoclonal",
"the recent advancements"
] | [] | 0 | 10.1101/cshperspect.a041574 | [
"Park",
"Cheung"
] | [
"Department of Pediatrics, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.",
"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA [email protected]."
] | [
"39009446"
] | [] | 6.499348 | 6.673145 |
39008193 | 725 | A dual-targeting approach with anti-IL10R CAR-T cells engineered to release anti-CD33 bispecific antibody in enhancing killing effect on acute myeloid leukemia cells. | Immunotherapies, including chimeric antigen receptor (CAR) T cells and bispecific antibodies (BsAbs), encounter several challenges in the management of acute myeloid leukemia (AML), including limited persistence of these treatments, antigen loss and resistance of leukemia stem cells (LSCs) to therapy.
Here, we proposed a novel dual-targeting approach utilizing engineered anti-IL10R CAR-T cells to secrete bispecific antibodies targeting CD33. This innovative strategy, rooted in our previous research which established a connection between IL-10 and the stemness of AML cells, designed to improve targeting efficiency and eradicate both LSCs and AML blasts.
We first demonstrated the superior efficacy of this synergistic approach in eliminating AML cell lines and primary cells expressing different levels of the target antigens, even in cases of low CD33 or IL10R expression. Furthermore, the IL10R CAR-T cells that secret anti-CD33 bsAbs (CAR.BsAb-T), exhibited an enhanced activation and induction of cytotoxicity not only in IL10R CAR-T cells but also in bystander T cells, thereby more effectively targeting CD33-positive tumor cells. Our in vivo experiments provided additional evidence that CAR.BsAb-T cells could efficiently redirect T cells, reduce tumor burden, and demonstrate no significant toxicity. Additionally, delivering bsAbs locally to the tumor sites through this strategy helps mitigate the pharmacokinetic challenges typically associated with the rapid clearance of prototypical bsAbs.
Overall, the engineering of a single-vector targeting IL10R CAR, which subsequently secretes CD33-targeted bsAb, addresses the issue of immune escape due to the heterogeneous expression of IL10R and CD33, and represents a promising progress in AML therapy aimed at improving treatment outcomes. | [
0.05004051327705383,
0.014431159012019634,
0.059317685663700104,
0.051961544901132584,
-0.049853093922138214,
-0.01432573702186346,
-0.021553030237555504,
-0.005265264771878719,
-0.000496729975566268,
0.014524867758154869,
-0.0007826150977052748,
-0.03884230926632881,
-0.07548245787620544,
0.014232027344405651,
0.011391478590667248,
-0.044417984783649445,
0.0435277484357357,
-0.03221241012215614,
0.0022490117698907852,
0.01751183718442917,
0.023251501843333244,
0.020358242094516754,
0.0110517842695117,
0.01741812750697136,
-0.018718337640166283,
-0.024036314338445663,
0.034859683364629745,
-0.04788520932197571,
-0.03462541103363037,
-0.030244523659348488,
0.029518280178308487,
-0.027339549735188484,
-0.01308409497141838,
-0.015567378140985966,
-0.01199472974985838,
0.043035779148340225,
0.051024455577135086,
-0.008422080427408218,
-0.011713603511452675,
-0.026121335104107857,
0.040482211858034134,
-0.00006222851516213268,
0.009007761254906654,
0.06386256217956543,
-0.06747035682201385,
0.01980770379304886,
0.003373517654836178,
-0.038256626576185226,
0.004588804207742214,
-0.0013258334947749972,
0.01588364504277706,
0.028440628200769424,
-0.019327444955706596,
0.025395091623067856,
-0.0008668066584505141,
0.017687540501356125,
-0.026519596576690674,
0.03167358413338661,
0.0047293673269450665,
-0.002783444942906499,
-0.007707550656050444,
-0.010319684632122517,
0.00022566987900063396,
0.018390357494354248,
-0.03603104501962662,
-0.02616818994283676,
-0.04943140596151352,
-0.034859683364629745,
-0.008099956437945366,
-0.038256626576185226,
0.01629362255334854,
-0.003935770597308874,
-0.004831861238926649,
0.027972083538770676,
0.021494461223483086,
-0.0024012885987758636,
-0.0020557374227792025,
0.04729953035712242,
-0.010184978134930134,
-0.0017262923065572977,
0.013142663054168224,
0.011274343356490135,
0.036897849291563034,
-0.051024455577135086,
-0.01905803196132183,
0.00033090930082835257,
0.006284348201006651,
-0.02462199330329895,
-0.05603787675499916,
-0.005054419860243797,
-0.013189516961574554,
-0.019104886800050735,
-0.058568015694618225,
0.05603787675499916,
0.0006892723613418639,
0.008392796851694584,
-0.02348577417433262,
-0.04364488646388054,
0.049384549260139465,
0.05613158643245697,
0.03912343457341194,
0.00019638588128145784,
-0.007648983038961887,
-0.01810923032462597,
0.04163014516234398,
-0.000986871076747775,
0.020674509927630424,
-0.007250720169395208,
0.020369956269860268,
-0.01748840883374214,
0.08307287096977234,
0.00004717470801551826,
-0.01782810315489769,
0.03591390699148178,
-0.012674118392169476,
-0.09188150614500046,
-0.05055591091513634,
0.010419249534606934,
0.0023646836634725332,
0.00809409935027361,
-0.012861535884439945,
0.012744400650262833,
0.029799405485391617,
-0.022091856226325035,
-0.027784666046500206,
-0.027597248554229736,
0.09230319410562515,
-0.026402462273836136,
-0.030057106167078018,
-0.046994976699352264,
0.030080532655119896,
-0.00042644835775718093,
0.005622529424726963,
-0.004495094995945692,
-0.060582756996154785,
-0.007900825701653957,
-0.025605935603380203,
-0.004398458171635866,
-0.03949826955795288,
-0.030385086312890053,
0.04835375398397446,
-0.001767289824783802,
-0.010512959212064743,
-0.00797110702842474,
-0.05983308330178261,
-0.035703063011169434,
0.002313436707481742,
0.010922934859991074,
0.016340475529432297,
0.012697545811533928,
-0.03160330280661583,
0.06479965150356293,
0.04324662312865257,
0.006143784616142511,
0.013294939883053303,
-0.03333691507577896,
-0.00938845332711935,
0.03666357696056366,
0.014056324027478695,
-0.053976282477378845,
0.016879301518201828,
0.011520328931510448,
-0.03645273298025131,
-0.02172873355448246,
0.021529601886868477,
0.010823369026184082,
0.027316123247146606,
0.02729269489645958,
-0.0683605894446373,
0.019503150135278702,
-0.024317439645528793,
-0.021799014881253242,
-0.060676462948322296,
-0.025746500119566917,
-0.05285177752375603,
-0.00877348892390728,
0.012697545811533928,
-0.039100006222724915,
-0.028909172862768173,
-0.011649178341031075,
0.0022914735600352287,
-0.003689785022288561,
0.013142663054168224,
0.008955049328505993,
-0.04003709554672241,
0.014114892110228539,
-0.029658842831850052,
0.0223612692207098,
-0.023661477491259575,
0.007180438842624426,
0.009288887493312359,
0.037296112626791,
0.029518280178308487,
0.0018434282392263412,
-0.00305432197637856,
0.023532629013061523,
0.0308536309748888,
0.024504857137799263,
-0.0010293328668922186,
-0.008088243193924427,
0.018156085163354874,
0.003596076276153326,
-0.054444827139377594,
0.011590610258281231,
-0.004301820881664753,
0.01364634744822979,
-0.0034818684216588736,
0.04748694598674774,
-0.009078042581677437,
-0.005288691725581884,
0.056740693747997284,
0.016059350222349167,
-0.001038850168697536,
-0.007795402780175209,
-0.022279273718595505,
0.007982820272445679,
-0.01874176412820816,
0.044511690735816956,
0.011409049853682518,
-0.0008016497013159096,
-0.0015666944673284888,
-0.02270096354186535,
-0.010887794196605682,
0.028534337878227234,
-0.04270779713988304,
-0.012252428568899632,
0.016645029187202454,
-0.028534337878227234,
-0.00592708308249712,
-0.0104543911293149,
0.0025052467826753855,
-0.010038557462394238,
0.014899702742695808,
-0.022572113201022148,
-0.029541706666350365,
-0.03125189244747162,
0.009160038083791733,
0.014232027344405651,
0.07243692129850388,
-0.03579677268862724,
0.008375226520001888,
0.03104104846715927,
0.054069992154836655,
-0.023813754320144653,
-0.026707015931606293,
-0.017757821828126907,
-0.0023236859124153852,
-0.05575675144791603,
-0.017945239320397377,
0.026707015931606293,
0.011660891585052013,
0.0027102348394691944,
-0.009236176498234272,
-0.017804676666855812,
-0.009628581814467907,
0.03654644265770912,
0.018999464809894562,
-0.029447998851537704,
0.01295524463057518,
-0.02516081929206848,
-0.0444648377597332,
0.019913125783205032,
-0.008047245442867279,
-0.0427546501159668,
-0.019538290798664093,
0.003944555763155222,
-0.0030777491629123688,
0.01751183718442917,
0.04694811999797821,
-0.00866220984607935,
-0.019128313288092613,
0.015169115737080574,
0.03668700531125069,
-0.01383376494050026,
-0.01001513097435236,
0.004448240622878075,
-0.01748840883374214,
0.02785494737327099,
-0.020803358405828476,
0.015051979571580887,
-0.008422080427408218,
-0.012861535884439945,
-0.004998780321329832,
-0.00982771348208189,
-0.008451364934444427,
-0.03411001339554787,
-0.01745326817035675,
-0.014817708171904087,
-0.010963932611048222,
-0.007063302677124739,
-0.018120944499969482,
-0.012299283407628536,
-0.021389039233326912,
-0.0221035685390234,
-0.026871005073189735,
-0.00027362245600670576,
0.005001708399504423,
-0.025371665135025978,
-0.0185192059725523,
0.03579677268862724,
-0.004468739498406649,
0.018577774986624718,
-0.012791254557669163,
-0.05739665403962135,
0.04554248973727226,
0.0004019229963887483,
-0.014255454763770103,
-0.010272829793393612,
0.0073034316301345825,
0.03420371934771538,
0.036804139614105225,
-0.015333106741309166,
0.010460247285664082,
0.013950901105999947,
0.0016399044543504715,
-0.03647616133093834,
-0.02858119085431099,
-0.0707501620054245,
-0.0009846747852861881,
-0.03987310454249382,
-0.012287569232285023,
-0.018390357494354248,
-0.03291522338986397,
-0.005631314590573311,
0.006858314853161573,
-0.015895359218120575,
0.028534337878227234,
-0.028089219704270363,
0.0173244196921587,
-0.04795549064874649,
0.037905219942331314,
-0.03427400439977646,
0.061238717287778854,
-0.01898775063455105,
-0.02346234768629074,
-0.007959393784403801,
-0.02820635586977005,
-0.024223731830716133,
0.03582019731402397,
0.04594075307250023,
-0.024411149322986603,
0.04868173599243164,
-0.042567234486341476,
0.045261360704898834,
0.023567769676446915,
-0.005684026051312685,
-0.009956562891602516,
-0.0011669676750898361,
0.033688321709632874,
0.047908637672662735,
0.02279467135667801,
-0.0017438626382499933,
0.012849822640419006,
-0.010530529543757439,
-0.03813949227333069,
0.0351642370223999,
-0.016656743362545967,
-0.03820977360010147,
0.0031919567845761776,
0.014595149084925652,
0.026894433423876762,
0.013060667552053928,
-0.053414031863212585,
0.01704329252243042,
0.040739912539720535,
0.04915027692914009,
-0.004735223948955536,
0.01199472974985838,
-0.004902143031358719,
-0.026332179084420204,
-0.008703206665813923,
0.020733077079057693,
0.0370384119451046,
0.017371272668242455,
-0.013201231136918068,
0.027245840057730675,
0.00709844334051013,
0.006741178687661886,
0.026308752596378326,
0.013939187861979008,
0.029518280178308487,
-0.012264142744243145,
-0.03785836696624756,
-0.04425399377942085,
-0.00573966559022665,
0.02292352169752121,
0.032563816756010056,
-0.03399287536740303,
-0.08204207569360733,
0.02996339648962021,
0.017347846180200577,
-0.03462541103363037,
0.035960759967565536,
-0.009581726975739002,
-0.0010146908462047577,
0.07276490330696106,
0.004653228912502527,
0.06479965150356293,
0.04324662312865257,
0.011737029999494553,
-0.0038157061208039522,
0.003751281416043639,
-0.005991507787257433,
-0.055897314101457596,
0.030385086312890053,
-0.028370346873998642,
0.0325169637799263,
0.015825077891349792,
0.004758651368319988,
-0.011871736496686935,
-0.008714920841157436,
-0.001229196204803884,
0.043035779148340225,
-0.0007244131411425769,
0.0037629948928952217,
-0.013986041769385338,
-0.055897314101457596,
0.05772463604807854,
0.012135292403399944,
0.012147006578743458,
0.027948657050728798,
-0.053320322185754776,
0.030713068321347237,
-0.02865147404372692,
0.02264239452779293,
-0.019327444955706596,
0.05303919315338135,
0.0111162094399333,
0.009107326157391071,
-0.04811948165297508,
-0.029518280178308487,
0.044863101094961166,
-0.0032183125149458647,
-0.02452828548848629,
-0.034391138702631,
0.055991023778915405,
-0.07299917191267014,
0.04811948165297508,
-0.040365077555179596,
0.03300893306732178,
-0.01710185967385769,
0.014805993996560574,
-0.012802967801690102,
-0.020299674943089485,
0.001986919902265072,
0.00248767645098269,
0.004547806456685066,
0.05392942950129509,
-0.036710433661937714,
0.00814681127667427,
-0.022630680352449417,
-0.04811948165297508,
0.0009034116519615054,
0.039826251566410065,
-0.034484848380088806,
0.004237395711243153,
0.04915027692914009,
-0.06456538289785385,
0.004052906762808561,
0.03305578976869583,
0.034227147698402405,
-0.05898970365524292,
0.015333106741309166,
0.012334424071013927,
-0.028510909527540207,
0.025676218792796135,
0.013505784794688225,
-0.023591196164488792,
0.02544194646179676,
-0.03050222247838974,
0.02553565427660942,
0.008832057006657124,
0.010038557462394238,
0.0459173247218132,
-0.041840989142656326,
0.0456596240401268,
0.028417201712727547,
-0.01119234785437584,
0.057818345725536346,
0.006530333776026964,
-0.028323492035269737,
-0.02766752988100052,
-0.023790327832102776,
-0.004304748959839344,
0.027245840057730675,
0.012310996651649475,
0.0021245547104626894,
-0.0070515889674425125,
-0.032563816756010056,
0.020358242094516754,
-0.02062765508890152,
-0.007877398282289505,
0.018858900293707848,
-0.010179121047258377,
-0.0059651522897183895,
-0.029518280178308487,
0.010120552964508533,
-0.019479721784591675,
0.01999512128531933,
0.011110352352261543,
0.0213773250579834,
0.0015959783922880888,
0.02663673274219036,
0.029658842831850052,
0.054069992154836655,
0.0066708968952298164,
-0.014208600856363773,
0.04216897115111351,
-0.02408316731452942,
0.014407731592655182,
-0.02006540261209011,
-0.022021573036909103,
0.028417201712727547,
-0.009482162073254585,
-0.03886573389172554,
-0.018507493659853935,
-0.05908341333270073,
-0.02626189775764942,
0.008427937515079975,
0.006120357662439346,
0.00012143712228862569,
-0.013950901105999947,
0.009962419047951698,
0.029447998851537704,
0.03535165265202522,
-0.009341598488390446,
-0.047650936990976334,
-0.00728000421077013,
-0.03778808191418648,
-0.03521108999848366,
0.03959197923541069,
-0.006395627278834581,
-0.030666213482618332,
0.04387915879487991,
-0.023766901344060898,
-0.021681878715753555,
-0.013388648629188538,
0.03970911353826523,
-0.04242667183279991,
-0.04811948165297508,
0.005842159502208233,
-0.003935770597308874,
0.031205039471387863,
-0.0012884963070973754,
-0.0047732931561768055,
0.004758651368319988,
0.023134365677833557,
-0.0272692684084177,
0.018905755132436752,
-0.017441555857658386,
0.010079555213451385,
-0.04024793952703476,
0.0406227745115757,
-0.018589487299323082,
0.021974720060825348,
-0.05294548720121384,
-0.018249792978167534,
-0.04118502885103226,
0.01741812750697136,
-0.00661818590015173,
-0.025933917611837387,
-0.03214212879538536,
-0.005599102471023798,
-0.022759530693292618,
0.01653960719704628,
0.002392503432929516,
-0.028885744512081146,
-0.012381278909742832,
-0.03326663374900818,
0.026121335104107857,
-0.0023236859124153852,
0.026051053777337074,
0.011186490766704082,
-0.01612963154911995,
0.06667383015155792,
0.008996047079563141,
-0.021084485575556755,
-0.001144272624514997,
-0.010934648104012012,
0.008568501099944115,
-0.02251354604959488,
-0.025043683126568794,
-0.03521108999848366,
0.05303919315338135,
-0.016809020191431046,
-0.008252233266830444,
-0.058099471032619476,
0.005760164465755224,
-0.018577774986624718,
0.035140808671712875,
-0.009165894240140915,
-0.04519107937812805,
0.00998584646731615,
0.01492313016206026,
-0.035609353333711624,
-0.0005838499055244029,
0.023286642506718636,
-0.016246767714619637,
-0.0156610868871212,
0.004978281445801258,
0.007479135412722826,
-0.023474059998989105,
-0.032657526433467865,
-0.012310996651649475,
-0.006647469941526651,
0.01657474786043167,
0.006694324314594269,
0.0004099761135876179,
-0.006641612853854895,
0.0058363028801977634,
0.05505393445491791,
0.03774122893810272,
-0.026027625426650047,
0.020100543275475502,
0.020229391753673553,
0.028417201712727547,
-0.029143445193767548,
-0.006009078584611416,
0.025231100618839264,
-0.021107912063598633,
-0.01735956035554409,
-0.02748011238873005,
-0.014220314100384712,
0.00691688247025013,
0.00882034283131361,
-0.05125872790813446,
-0.0497593879699707,
-0.010108839720487595,
0.026613306254148483,
-0.00500756548717618,
-0.022068427875638008,
-0.012791254557669163,
-0.028276637196540833,
0.04059934988617897,
0.00809409935027361,
-0.017804676666855812,
0.011133779771625996,
-0.0177929624915123,
-0.0006588901742361486,
-0.004618088249117136,
-0.02059251442551613,
0.016563035547733307,
-0.003976768348366022,
-0.013845479115843773,
0.009429450146853924,
-0.015895359218120575,
-0.02144760824739933,
-0.003944555763155222,
0.02499682828783989,
-0.029284007847309113,
-0.021271903067827225,
-0.014981698244810104,
0.04263751581311226,
0.011801455169916153,
0.020885353907942772,
-0.007566987536847591,
0.003109961748123169,
-0.017980379983782768,
0.05772463604807854,
0.06704866141080856,
-0.044511690735816956,
0.029541706666350365,
-0.010852653533220291,
-0.0017951097106561065,
-0.0023163650184869766,
-0.014243741519749165,
0.0021245547104626894,
-0.004418956581503153,
0.001247498788870871,
0.007080873008817434,
0.06995363533496857,
-0.011719459667801857,
0.015696227550506592,
-0.011338767595589161,
-0.002508175326511264,
0.035421937704086304,
0.007976964116096497,
-0.0025272099301218987,
-0.05210210755467415,
-0.01451315451413393,
-0.009160038083791733,
-0.0033208064269274473,
-0.03380545973777771,
-0.07295232266187668,
-0.013142663054168224,
0.008140954189002514,
0.015005125664174557,
-0.015180829912424088,
-0.013857192359864712,
-0.03223583474755287,
0.010214261710643768,
-0.004544877912849188,
-0.004126116633415222,
-0.012920103967189789,
0.003443799214437604,
0.0016574747860431671,
-0.011379765346646309,
-0.009441164322197437,
-0.02361462451517582,
-0.032306116074323654,
0.017980379983782768,
-0.0073502860032022,
0.07196837663650513,
-0.0050661335699260235,
0.02232612669467926,
-0.015543951652944088,
-0.0062374938279390335,
-0.001123773748986423,
0.014688858762383461,
0.07182781398296356,
-0.015169115737080574,
0.004656157456338406,
-0.044863101094961166,
-0.0382332019507885,
-0.0020103470887988806,
-0.0003642198571469635,
-0.006723608355969191,
0.05556933209300041,
-0.025324810296297073,
0.011924448423087597,
-0.022279273718595505,
0.01905803196132183,
-0.03769437596201897,
0.006524477154016495,
0.03537508100271225,
0.034859683364629745,
-0.0361013263463974,
0.05898970365524292,
0.007678267080336809,
-0.01943286694586277,
-0.0028346918988972902,
-0.01760554499924183,
-0.007361999712884426,
-0.011772171594202518,
-0.005455610807985067,
0.03511738404631615,
-0.02333349734544754,
-0.01056567020714283,
-0.01199472974985838,
-0.007086730096489191,
0.03310264274477959,
-0.021389039233326912,
-0.02374347299337387,
0.030713068321347237,
-0.008990189991891384,
0.024575138464570045,
0.013763483613729477,
0.013927473686635494,
-0.01272097323089838,
-0.009452877566218376,
-0.0002608106879051775,
0.007842257618904114,
0.022853240370750427,
-0.00679974677041173,
0.005358973518013954,
-0.023263216018676758,
0.002076236065477133,
-0.0024759629741311073,
-0.016434185206890106,
-0.006870028097182512,
-0.02094392292201519,
0.006852457765489817,
-0.018132656812667847,
0.00760212866589427,
-0.02417687699198723,
0.006389770656824112,
-0.0031568161211907864,
0.017945239320397377,
0.01104007102549076,
0.022536972537636757,
-0.02949485182762146,
-0.021283617243170738,
0.024364294484257698,
-0.030923912301659584,
-0.02562936395406723,
0.023075798526406288,
-0.02219727821648121,
0.001636976026929915,
0.0005022207624278963,
0.006419054698199034,
0.0010300650028511882,
0.004741081036627293,
-0.030923912301659584,
0.012369564734399319,
0.019725708290934563,
0.005672312341630459,
0.008070672862231731,
0.02204500138759613,
-0.025887062773108482,
-0.01898775063455105,
-0.030525648966431618,
0.03687442094087601,
-0.018659770488739014,
0.001982527319341898,
0.011356337927281857,
0.034414567053318024,
0.036897849291563034,
-0.07599785923957825,
-0.030713068321347237,
-0.02314607985317707,
0.004178828094154596,
-0.010143980383872986,
0.006454195361584425,
-0.011508614756166935,
0.009546586312353611,
-0.00797110702842474,
-0.01603592187166214,
0.007244863547384739,
-0.011678461916744709,
0.00016444800712633878,
0.0022548686247318983,
0.00889648124575615,
-0.03760066628456116,
-0.025231100618839264,
-0.048728588968515396,
0.013997755944728851,
0.04673727601766586,
0.014571722596883774,
0.007672409992665052,
-0.024106595665216446,
0.06376885622739792,
0.004105617757886648,
0.002634096425026655,
-0.0076196989975869656,
0.015801651403307915,
-0.0351642370223999,
-0.02600419893860817,
0.04505051672458649,
0.021178195253014565,
-0.024012885987758636,
0.04308263212442398,
0.0073678563348948956,
-0.041747283190488815,
0.023474059998989105,
0.016141345724463463,
-0.002688271924853325,
0.012568696402013302,
-0.005549319554120302,
0.02144760824739933,
0.024200303480029106,
0.011824882589280605,
-0.021904438734054565,
-0.011397335678339005,
-0.05917712301015854,
-0.023790327832102776,
0.007508419454097748,
-0.009663722477853298,
-0.004459954332560301,
-0.006823173724114895,
-0.06423740088939667,
0.015145689249038696,
-0.0004608570598065853,
-0.06184782460331917,
0.006126214284449816,
0.008785202167928219,
0.03097076714038849,
0.035960759967565536,
-0.010559813119471073,
0.04416028410196304,
0.009933135472238064,
0.004448240622878075,
0.01666845753788948,
-0.0031187469139695168,
-0.043129485100507736,
0.036897849291563034,
-0.037530384957790375,
0.017933527007699013,
-0.01520425733178854,
0.007672409992665052,
-0.019503150135278702,
0.008814486674964428,
0.04188784584403038,
-0.027058422565460205,
-0.022466691210865974,
0.010507102124392986,
0.0004736688279081136,
0.0039796968922019005,
0.0032563817221671343,
-0.016375618055462837,
-0.007203865796327591,
0.013189516961574554,
-0.031907856464385986,
-0.015192543156445026,
0.015602519735693932,
0.019069746136665344,
0.0018141443142667413,
0.019550003111362457,
0.01543852873146534,
-0.019913125783205032,
-0.009113183245062828,
0.004439455457031727,
-0.002164088189601898,
-0.010155693627893925,
-0.015672801062464714,
0.0001315950066782534,
-0.015637660399079323,
-0.002253404352813959,
0.04282493144273758,
-0.024458004161715508,
0.022466691210865974,
-0.030525648966431618,
-0.0026004198007285595,
-0.027081850916147232,
0.05955195799469948,
-0.016844160854816437,
0.005288691725581884,
-0.013002099469304085,
0.0384908989071846,
-0.0009678364731371403,
0.012252428568899632,
-0.018214652314782143,
0.0038244915194809437,
0.026800723746418953,
0.030080532655119896,
-0.0222324188798666,
0.009558300487697124,
0.004322319757193327,
0.033032361418008804,
0.03502367436885834,
-0.020768217742443085,
-0.024223731830716133,
0.008369369432330132,
0.015895359218120575,
0.024926546961069107,
0.0010337254498153925,
-0.00995070580393076,
-0.0055639613419771194,
0.011883450672030449,
0.04125531017780304,
-0.014114892110228539,
-0.030525648966431618,
-0.010811655782163143,
0.009066328406333923,
0.006219923496246338,
0.004471668042242527,
-0.005766021087765694,
0.0471121110022068,
-0.010600810870528221,
-0.019069746136665344,
-0.003660500980913639,
0.003604861441999674,
0.01921030879020691,
-0.012744400650262833,
-0.03654644265770912,
0.02839377336204052,
-0.018003808334469795,
0.024926546961069107,
-0.024949975311756134,
0.04509737342596054,
0.044886525720357895,
0.05144614353775978,
0.009042901918292046,
0.029611987993121147,
0.0375538133084774,
-0.059223975986242294,
-0.04666699469089508,
0.03223583474755287,
-0.03443799167871475,
0.05008736625313759,
-0.026589879766106606,
-0.014044609852135181,
0.000135530048282817,
-0.0072624338790774345,
-0.02195129171013832,
-0.002328078728169203,
0.0009524623746983707,
0.02616818994283676,
0.01861291565001011,
-0.04245009645819664,
0.04348089545965195,
-0.01323637180030346,
-0.03235297277569771,
-0.0019459222676232457,
-0.015297966077923775,
-0.011385622434318066,
0.033946022391319275,
0.03415686637163162,
-0.028323492035269737,
-0.010811655782163143,
0.003648787271231413,
0.009365025907754898,
0.020779931917786598,
0.005593245383352041,
-0.01622334122657776,
-0.01676216535270214,
0.04052906855940819,
-0.016516180709004402,
0.019678853452205658,
-0.02329835668206215,
0.019034605473279953,
0.036429304629564285,
0.04584704339504242,
-0.02219727821648121,
-0.014349163509905338,
0.04057592153549194,
-0.04587046802043915,
-0.049946803599596024,
-0.037296112626791,
0.022806385532021523,
0.0193742997944355,
-0.01990141160786152,
-0.04118502885103226,
0.007807116489857435,
0.021025918424129486,
-0.048728588968515396,
-0.009089755825698376,
0.054069992154836655,
-0.012592123821377754,
0.003865489037707448,
-0.0501810759305954,
0.01833178848028183,
0.013505784794688225,
0.008228805847465992,
0.010079555213451385,
0.0030133244581520557,
-0.007145297713577747,
-0.012299283407628536,
-0.0077368346974253654,
-0.02949485182762146,
0.02383718267083168,
0.018624629825353622,
0.003300307784229517,
-0.017710968852043152,
0.0186480563133955,
0.0028420130256563425,
-0.0048757875338196754,
0.023099225014448166,
-0.021049344912171364,
0.03767094761133194,
0.014396018348634243,
-0.013751770369708538,
-0.02626189775764942,
0.009581726975739002,
-0.02097906358540058,
-0.02434086799621582,
0.006454195361584425,
-0.01946800760924816,
0.03924056887626648,
0.03502367436885834,
-0.0072214361280202866,
-0.05182097852230072,
0.00043633172754198313,
0.01053638570010662,
0.027690958231687546,
-0.01842549815773964,
-0.005493680015206337,
-0.03209527209401131,
-0.014044609852135181,
0.0037337110843509436,
0.03015081398189068,
0.03352433070540428,
0.03619503229856491,
0.007883255369961262,
0.012943531386554241,
0.01152618508785963,
0.05060276389122009,
0.02949485182762146,
0.00803553219884634,
-0.011901021003723145,
-0.01786324568092823,
-0.004864073824137449,
-0.011496901512145996,
0.007502562832087278,
-0.024856265634298325,
-0.008064815774559975,
0.00011411611922085285,
0.020897068083286285,
0.020241105929017067,
-0.014044609852135181,
0.01689101569354534,
-0.000047494999307673424,
-0.0012577481102198362,
-0.014114892110228539,
0.014396018348634243,
0.0017145787132903934,
0.00661818590015173,
-0.027316123247146606,
-0.022501831874251366,
0.0018068233039230108,
-0.033407196402549744,
0.005613744258880615,
0.013435502536594868,
0.0015710870502516627,
-0.026777297258377075,
-0.013798624277114868,
-0.0002035238576354459,
-0.018636342138051987,
-0.03530479967594147,
0.0337117500603199,
-0.03895944356918335,
0.0041085463017225266,
-0.015485383570194244,
-0.03518766537308693,
-0.002243154915049672,
-0.008556786924600601,
-0.023755187168717384,
-0.01883547380566597,
-0.027152132242918015,
0.024785984307527542,
-0.01432573702186346,
-0.004199326504021883,
0.002063058316707611,
-0.0216350257396698,
-0.022021573036909103,
-0.02298208884894848,
0.0355859249830246,
-0.0106886625289917,
-0.031181611120700836,
0.03167358413338661,
0.02408316731452942,
-0.029354289174079895,
0.0009802822023630142,
-0.007274147588759661,
-0.005473181139677763,
0.01584850437939167,
0.020264534279704094,
-0.00288886739872396,
-0.0042344676330685616,
0.0077368346974253654,
0.004319391213357449,
0.011813168413937092,
-0.03656986728310585,
-0.0005322368233464658,
0.02637903392314911,
-0.02848748303949833,
-0.02663673274219036,
-0.020194251090288162,
0.015473669394850731,
-0.012346137315034866,
-0.006653326563537121,
-0.032399825751781464,
-0.015309679321944714,
0.024012885987758636,
0.020838499069213867,
-0.011409049853682518,
0.010436820797622204,
-0.025769926607608795,
-0.01061252411454916,
-0.024481430649757385,
0.02647274360060692,
0.004957782570272684,
0.012334424071013927,
-0.013365221209824085,
0.0016516180476173759,
-0.02182244323194027,
-0.014442872256040573,
-0.010255259461700916,
0.05463224649429321,
-0.031111329793930054,
-0.045893896371126175,
0.02305237017571926,
-0.002477427013218403,
-0.0020601300057023764,
-0.02626189775764942,
-0.0006252135499380529,
-0.012147006578743458,
-0.02122504822909832,
0.0022211920004338026,
0.02830006554722786,
0.05191468819975853,
-0.0030923911835998297,
0.003590219421312213,
0.024387720972299576,
-0.010594953782856464,
-0.008890625089406967,
-0.006975450552999973,
0.01898775063455105,
0.0061320713721215725,
0.04467568174004555,
-0.03525794669985771,
-0.008796916343271732,
0.003877202747389674,
0.010190834291279316,
0.04807262867689133,
0.018601201474666595,
0.01672702468931675,
0.037998929619789124,
0.009195178747177124,
0.012439846992492676,
0.010899507440626621,
-0.010337254963815212,
-0.02292352169752121,
-0.024481430649757385,
-0.02738640457391739,
-0.02336863800883293,
0.001742398482747376,
0.003874274203553796,
0.0033120212610810995,
0.025324810296297073,
-0.001371955731883645,
0.028979454189538956,
-0.02644931524991989,
-0.01892918348312378,
0.0012650691205635667,
0.006934453267604113,
-0.03298550471663475,
0.0029430428985506296,
-0.03839718922972679,
0.002780516631901264,
0.016422471031546593,
0.003654644126072526,
0.00884962733834982,
0.018062375485897064,
0.019034605473279953,
0.022911807522177696,
-0.00654204748570919,
0.020100543275475502,
-0.017031578347086906,
-0.011860023252665997,
-0.06864171475172043,
0.01836692914366722,
-0.024130022153258324,
0.015895359218120575,
-0.00845722109079361,
-0.009646152146160603,
-0.020920494571328163,
-0.009247889742255211,
0.010577383451163769,
-0.01437259092926979,
0.024856265634298325,
-0.00028112647123634815,
0.0014385768445208669,
-0.0006687735440209508,
0.019362585619091988,
-0.00925960298627615,
-0.019503150135278702,
0.01202987041324377,
0.01240470539778471,
0.008837913163006306,
0.021049344912171364,
-0.001502269646152854,
-0.029518280178308487,
-0.005192054435610771,
-0.014630290679633617,
0.020955635234713554,
-0.017277564853429794,
-0.01846063882112503,
-0.0078305434435606,
-0.01993655227124691,
0.05519449710845947,
0.03244668245315552,
0.01492313016206026,
-0.009552443400025368,
-0.03731954097747803,
0.002307579852640629,
0.03989653289318085,
-0.004442384000867605,
0.030572503805160522,
0.014618576504290104,
-0.04151301085948944,
-0.001622334006242454,
-0.020393382757902145,
-0.0070925867184996605,
-0.041559863835573196,
-0.031931281089782715,
0.024551711976528168,
0.022056715562939644,
-0.016340475529432297,
0.00070354831404984,
-0.0029474354814738035,
0.019854556769132614,
-0.008164381608366966,
0.011245058849453926,
-0.005104202777147293,
0.0002492801286280155,
-0.023684905841946602,
0.002948899520561099,
-0.01323637180030346,
0.024832839146256447,
0.026238471269607544,
-0.00665918318554759,
0.01689101569354534,
-0.0173244196921587,
0.022595539689064026,
0.03300893306732178,
0.023954318836331367,
-0.0346488393843174,
-0.02921372652053833,
0.014571722596883774,
-0.02107277140021324,
0.0114793311804533,
0.013997755944728851,
0.011403192766010761,
0.003470154944807291,
-0.02977597899734974,
0.010747230611741543,
0.04467568174004555,
-0.0016955441096797585,
-0.018601201474666595,
-0.022208992391824722,
-0.01122748851776123,
-0.004843574948608875,
-0.000788471894338727,
-0.007918396033346653,
0.012978672049939632,
-0.0023602910805493593,
0.014396018348634243,
-0.011268486268818378,
-0.01726585067808628,
0.0049197133630514145,
-0.023532629013061523,
0.021611597388982773,
0.011391478590667248,
-0.03528137132525444,
-0.021365612745285034,
0.011684319004416466,
0.0313221737742424,
-0.021307043731212616,
-0.017570404335856438,
-0.014548295177519321,
0.007561130914837122,
0.03959197923541069,
-0.024036314338445663,
-0.009921422228217125,
0.03509395569562912,
0.020182538777589798,
-0.030830202624201775,
-0.005994436331093311,
0.015778223052620888,
0.005329689476639032,
-0.01776953600347042,
-0.03279808908700943,
-0.01507540699094534,
0.004298892337828875,
0.009529015980660915,
-0.0024217874743044376,
0.029049735516309738,
0.04104446619749069,
-0.020393382757902145,
0.007883255369961262,
-0.03167358413338661,
-0.0015286252601072192,
0.031931281089782715,
-0.0215061753988266,
-0.0018214653246104717,
0.005244765896350145,
-0.0049607111141085625,
-0.015801651403307915,
0.006993020884692669,
0.014817708171904087,
-0.006296061910688877,
0.01758211851119995,
0.011391478590667248,
0.031556446105241776,
-0.014407731592655182,
-0.01173117384314537,
0.03828005492687225,
0.06817317008972168,
0.0036751430016011,
-0.007016448304057121,
0.019866270944476128,
-0.0012262677773833275,
-0.03467226400971413,
0.02764410339295864,
-0.00032523550908081234,
-0.01965542696416378,
-0.009335741400718689,
0.019667139276862144,
0.02389574982225895,
0.002839084481820464,
0.006811460014432669,
-0.0068407440558075905,
-0.014208600856363773,
-0.015590805560350418,
-0.010307970456779003,
-0.019678853452205658,
-0.0019210309255868196,
0.010261116549372673,
-0.022056715562939644,
-0.005938796792179346,
0.005522964056581259,
-0.016973011195659637,
0.01958514377474785,
-0.009546586312353611,
-0.010946362279355526,
0.00537654384970665,
-0.012205574661493301,
-0.02191615104675293,
0.017031578347086906,
-0.027503540739417076,
0.0027234128210693598,
0.003124603535979986,
-0.02154131606221199,
-0.030549077317118645,
-0.008486505597829819,
-0.008474791422486305,
0.015133975073695183,
-0.017558692023158073,
-0.01782810315489769,
0.023064084351062775,
-0.017090147361159325,
0.0228298120200634,
0.029916541650891304,
-0.00803553219884634,
0.025769926607608795,
-0.03795207291841507,
-0.010190834291279316,
-0.021494461223483086,
0.044324275106191635,
0.0028771536890417337,
0.01644589938223362,
0.0019415296847000718,
0.00580994738265872,
-0.0011259701568633318,
-0.0157899372279644,
-0.004190541338175535,
0.02311093918979168,
-0.020897068083286285,
0.006296061910688877,
0.000564815301913768,
-0.01717214286327362,
-0.015497096814215183,
0.015309679321944714,
-0.03481282666325569,
0.015227683819830418,
0.010858509689569473,
0.007274147588759661,
0.01808580383658409,
0.023415492847561836,
-0.025488801300525665,
0.010952219367027283,
-0.012896677479147911,
0.02405974082648754,
-0.032024990767240524,
-0.00841036718338728,
0.016176486387848854,
-0.00121675047557801,
-0.0003331055922899395,
0.05271121487021446,
0.002458392409607768,
-0.022115282714366913,
-0.011075211688876152,
-0.02773781307041645,
-0.032118700444698334,
-0.00043120700865983963,
-0.029260581359267235,
0.012346137315034866,
0.010138123296201229,
0.0250905379652977,
-0.013974328525364399,
0.018495779484510422,
-0.026988141238689423,
0.021939579397439957,
-0.01836692914366722,
-0.013845479115843773,
0.004995851777493954,
-0.015133975073695183,
-0.02260725386440754,
0.01276782713830471,
0.020381668582558632,
-0.001442237407900393,
0.015602519735693932,
0.03232954442501068,
0.0004114402981940657,
0.03244668245315552,
-0.018249792978167534,
-0.009083899669349194,
0.001642832881771028,
-0.004887500777840614,
-0.0059651522897183895,
0.02499682828783989,
0.04118502885103226,
0.012182147242128849,
0.034133438020944595,
0.015778223052620888,
-0.0007921323995105922,
0.00636634323745966,
-0.014384305104613304,
-0.026847578585147858,
-0.03525794669985771,
-0.010840939357876778,
0.08096442371606827,
-0.008843770250678062,
-0.010102982632815838,
0.008802772499620914,
-0.0073502860032022,
-0.006296061910688877,
0.012252428568899632,
-0.002273903228342533,
0.028956027701497078,
-0.0399433858692646,
0.029822833836078644,
0.034953393042087555,
0.0408804751932621,
0.009001904167234898,
0.032844942063093185,
-0.014021183364093304,
0.004243252798914909,
0.03197813779115677,
-0.016973011195659637,
-0.014442872256040573,
0.0010959539795294404,
0.023977745324373245,
-0.022091856226325035,
0.04310606047511101,
-0.012240715324878693,
-0.014712285250425339,
0.011157207190990448,
0.00048355216858908534,
0.006928596179932356,
-0.032680951058864594,
-0.0030455368105322123,
0.00016490556299686432,
0.017570404335856438,
-0.046994976699352264,
0.028159501031041145,
-0.01999512128531933,
-0.02254868671298027,
-0.013868906535208225,
-0.0010322612943127751,
0.02958856150507927,
0.001469325041398406,
0.0024598566815257072,
0.015379960648715496,
0.02986968867480755,
0.011098639108240604,
-0.0008265411015599966,
-0.020873641595244408,
-0.0025052467826753855,
0.023028943687677383,
-0.009968276135623455,
-0.0077134077437222,
-0.01474742591381073,
0.009751575067639351,
-0.011086924932897091,
-0.01023768913000822,
-0.013740056194365025,
0.007900825701653957,
-0.021424179896712303,
0.017652399837970734,
-0.017570404335856438,
-0.016973011195659637,
0.0325169637799263,
0.018343502655625343,
-0.010477817617356777,
0.016363903880119324
] | 2024-07-15 | 54 | 39008193 | [
"AML cells",
"T cells",
"AML cell lines",
"bystander T cells",
"leukemia stem cells",
"primary cells",
"AML therapy",
"engineered anti-IL10R CAR-T cells",
"AML blasts",
"secret anti-CD33 bsAbs",
"AML",
"IL10R CAR-T cells",
"CAR.BsAb-T cells",
"tumor burden",
"acute myeloid leukemia",
"bispecific antibodies",
"CD33-positive tumor cells",
"several challenges",
"CD33",
"IL10R",
"prototypical bsAbs",
"CAR",
"bsAbs",
"CD33-targeted bsAb",
"additional evidence",
"treatment outcomes",
"immune escape",
"different levels",
"limited persistence",
"a single-vector targeting IL10R CAR"
] | [
"AML",
"CD33",
"Chimeric antigen receptor",
"IL10R",
"Immunotherapy",
"Secretion of T cell-redirecting bsAbs"
] | 0 | 10.1007/s13402-024-00971-5 | [
"Yan",
"Gu",
"Ma",
"Chen",
"Zhang",
"Xu",
"Qiu",
"Xing",
"Tang",
"Tian",
"Rao",
"Wang",
"Wang"
] | [
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.\nThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.\nNanfang Hospital, Southern Medical University, Guangzhou, 510515, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.\nTianjin Institutes of Health Science, Tianjin, 301617, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China. [email protected].\nTianjin Institutes of Health Science, Tianjin, 301617, China. [email protected].",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China. [email protected].\nTianjin Institutes of Health Science, Tianjin, 301617, China. [email protected]."
] | [
"39008193",
"32786187",
"29385370",
"29226797",
"24457417",
"29311388",
"33046866",
"36715330",
"11410481",
"28607471",
"28668350",
"24809231",
"28408462",
"27571406",
"34767461",
"36813894",
"34766343",
"25174587",
"1373089",
"22286199",
"34381181",
"34392305",
"24311721",
"35680594",
"24274181",
"28071970",
"12109064",
"12847281",
"31332324",
"29440406",
"29856956",
"26840021",
"29409351",
"37488603",
"34620838",
"27381735",
"27784674",
"30528964",
"30581986",
"34642489",
"35622074",
"25142939",
"30827461",
"35570396",
"27258611",
"27401038",
"32145203",
"37078788",
"30135176",
"35355682",
"15102367",
"37635172",
"33496755",
"32894185"
] | [] | 6.847997 | 7.191754 |
39008028 | 726 | Predictive model for CAR-T cell therapy success in patients with relapsed/refractory B-cell acute lymphoblastic leukaemia. | Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated remarkable efficacy in treating relapsed/refractory acute B-cell lymphoblastic leukaemia (R/R B-ALL). However, a subset of patients does not benefit from CAR-T therapy. Our study aims to identify predictive indicators and establish a model to evaluate the feasibility of CAR-T therapy. Fifty-five R/R B-ALL patients and 22 healthy donors were enrolled. Peripheral blood lymphocyte subsets were analysed using flow cytometry. Sensitivity, specificity, accuracy, positive and negative predictive values and receiver operating characteristic (ROC) areas under the curve (AUC) were determined to evaluate the predictive values of the indicators. We identified B lymphocyte, regulatory T cell (Treg) and peripheral blood minimal residual leukaemia cells (B-MRD) as indicators for predicting the success of CAR-T cell preparation with AUC 0.936, 0.857 and 0.914. Furthermore, a model based on CD3 | [
0.009345661848783493,
0.008189254440367222,
0.03398422524333,
0.036533042788505554,
-0.01040766853839159,
-0.0193285271525383,
-0.022396547719836235,
0.004032676573842764,
0.0003776024968829006,
0.016921311616897583,
-0.052864350378513336,
-0.033960625529289246,
-0.03936506062746048,
-0.008029952645301819,
0.03740624710917473,
-0.026078172028064728,
0.042621880769729614,
0.010820670984685421,
-0.023930558934807777,
0.05697077512741089,
0.03655664250254631,
0.033488620072603226,
0.0025768419727683067,
-0.018691323697566986,
0.007475349586457014,
-0.031034205108880997,
0.042385879904031754,
0.007841152139008045,
-0.01100357249379158,
-0.04205547645688057,
-0.016543708741664886,
-0.0277301836758852,
-0.03535303473472595,
-0.020543934777379036,
-0.042385879904031754,
0.03561263531446457,
0.024614961817860603,
0.007056446745991707,
-0.05550756677985191,
-0.03018459863960743,
-0.0012286831624805927,
0.04205547645688057,
0.04922992363572121,
0.07858851552009583,
-0.04337708652019501,
-0.026620976626873016,
-0.006690644193440676,
-0.05338355153799057,
0.009156860411167145,
0.01712191291153431,
-0.047979116439819336,
0.01192987896502018,
-0.0010273442603647709,
0.024260960519313812,
-0.02706937864422798,
0.06461722403764725,
-0.03344142064452171,
0.003829125314950943,
0.011162873357534409,
0.01431349478662014,
-0.0027302431408315897,
-0.006849945057183504,
0.006731944624334574,
-0.02033153362572193,
-0.05498836189508438,
-0.006578543223440647,
-0.042433079332113266,
-0.039034657180309296,
0.012366482056677341,
0.020543934777379036,
0.009906165301799774,
-0.014596696011722088,
0.027470581233501434,
0.005587337072938681,
0.0554603673517704,
0.023517554625868797,
0.03190740942955017,
0.028886590152978897,
-0.027423381805419922,
-0.0007367673679254949,
0.04299948364496231,
0.001957337837666273,
0.02247914858162403,
-0.05815078318119049,
-0.02219594642519951,
-0.0029190443456172943,
0.0187385231256485,
-0.018679523840546608,
-0.002644692547619343,
-0.010726271197199821,
-0.02003653161227703,
-0.0052008843049407005,
-0.05838678404688835,
0.07254687696695328,
0.0009270436130464077,
0.0052215345203876495,
0.006661144085228443,
-0.0792965218424797,
0.025204965844750404,
0.0466575063765049,
0.032945819199085236,
0.027234580367803574,
0.015222100540995598,
-0.04158347472548485,
0.027116579934954643,
0.020555736497044563,
-0.04127667099237442,
0.0008260054746642709,
0.014927098527550697,
-0.012449081987142563,
0.06900685280561447,
0.013723490759730339,
-0.011215973645448685,
0.02916979230940342,
-0.027706582099199295,
-0.059566792100667953,
-0.04656310752034187,
-0.03204901143908501,
-0.0036550741642713547,
0.020437734201550484,
0.007493049371987581,
0.03978986293077469,
0.04838031902909279,
-0.04658670723438263,
-0.02862698957324028,
-0.013050885871052742,
0.05347795411944389,
-0.031647808849811554,
-0.01765291579067707,
-0.054657962173223495,
0.02444976195693016,
-0.005165484268218279,
0.029382193461060524,
-0.0010103816166520119,
-0.037547849118709564,
-0.021853744983673096,
-0.010201167315244675,
-0.022207746282219887,
-0.05881159007549286,
-0.035164233297109604,
0.01747591607272625,
0.020355135202407837,
-0.02313995361328125,
0.011056672781705856,
-0.0511651374399662,
-0.047271113842725754,
0.009487262926995754,
-0.011640776880085468,
-0.010189367458224297,
0.05673477426171303,
-0.03447982668876648,
0.03702864423394203,
0.014938898384571075,
0.0009484312613494694,
0.005248084664344788,
-0.03761864826083183,
0.011711576953530312,
0.01580030471086502,
-0.03698144480586052,
-0.05786758288741112,
-0.011723377741873264,
0.0015664603561162949,
-0.04408509284257889,
-0.018030518665909767,
0.01428989414125681,
0.0029529694002121687,
-0.017747316509485245,
0.025063365697860718,
-0.06688284128904343,
-0.013286887668073177,
-0.012413682416081429,
-0.0013127586571499705,
-0.05144834145903587,
-0.06848765164613724,
-0.05111793801188469,
0.00222873967140913,
0.031529806554317474,
-0.007392748724669218,
-0.0062776412814855576,
-0.04618550464510918,
-0.0029942698311060667,
0.023517554625868797,
0.027399780228734016,
-0.015705903992056847,
-0.020886138081550598,
0.010525669902563095,
-0.008578656241297722,
0.028343787416815758,
-0.030090197920799255,
-0.03261541575193405,
0.023753557354211807,
0.0049294824711978436,
0.06065240129828453,
0.031647808849811554,
0.020307933911681175,
-0.025016164407134056,
0.03398422524333,
0.04632710665464401,
-0.044769495725631714,
-0.03388982266187668,
-0.0016328358324244618,
0.005693537648767233,
-0.020980538800358772,
-0.024237360805273056,
-0.012614283710718155,
0.024024957790970802,
-0.00021940769511274993,
0.03273341432213783,
-0.007162647321820259,
-0.013723490759730339,
0.04460429400205612,
-0.0132750878110528,
-0.049465928226709366,
0.022467348724603653,
-0.037665847688913345,
0.015434501692652702,
-0.000056326935009565204,
0.0511651374399662,
0.022207746282219887,
0.030515002086758614,
-0.013652689754962921,
-0.014632096514105797,
-0.009847165085375309,
0.03797265142202377,
-0.05262834578752518,
0.017582116648554802,
0.037241045385599136,
-0.03615543991327286,
-0.029075391590595245,
-0.05498836189508438,
-0.032591816037893295,
0.0046108802780508995,
0.012708683498203754,
-0.023694556206464767,
-0.008867758326232433,
-0.009463662281632423,
0.024850964546203613,
0.012413682416081429,
0.056026771664619446,
-0.04720031097531319,
0.0031152204610407352,
0.04066306725144386,
0.004489929415285587,
0.003472172887995839,
0.01790071837604046,
-0.028603387996554375,
0.012154079973697662,
-0.05833958461880684,
0.011906278319656849,
0.0036137739662081003,
-0.007965052500367165,
-0.003926475998014212,
-0.0172871146351099,
-0.012508082203567028,
0.008897258900105953,
0.021015938371419907,
0.029240593314170837,
-0.039034657180309296,
0.02159414254128933,
-0.03953026235103607,
-0.024968964979052544,
-0.00864355731755495,
-0.02259714901447296,
-0.03761864826083183,
-0.031293805688619614,
0.01980053074657917,
-0.013334088027477264,
0.01115697342902422,
0.018290121108293533,
-0.007487149443477392,
0.01782991737127304,
0.012862085364758968,
0.0616908073425293,
-0.03174221143126488,
-0.02881579101085663,
0.0068145450204610825,
0.018986325711011887,
0.03422022610902786,
-0.0055135865695774555,
0.002789243357256055,
0.014254494570195675,
0.011050772853195667,
-0.009634763933718204,
-0.016897711902856827,
-0.017700117081403732,
-0.016567310318350792,
0.009050659835338593,
-0.023340554907917976,
-0.00014869941514916718,
-0.009982866235077381,
0.015257501043379307,
-0.026196172460913658,
-0.004858681932091713,
-0.061218805611133575,
-0.014455095864832401,
0.007251148112118244,
-0.011351674795150757,
-0.04217347875237465,
-0.046256303787231445,
0.04790831729769707,
-0.03308741748332977,
0.009451862424612045,
-0.037075843662023544,
-0.022266747429966927,
0.04314108565449715,
0.0009307311265729368,
0.0001576416689204052,
0.016602709889411926,
0.015233900398015976,
0.028603387996554375,
0.01628410816192627,
0.032473813742399216,
0.020862538367509842,
0.015092299319803715,
-0.03261541575193405,
-0.028320187702775,
0.02218414656817913,
-0.07523729652166367,
0.017570316791534424,
-0.0361318401992321,
-0.06518363207578659,
-0.013735290616750717,
-0.03320541977882385,
0.019234126433730125,
-0.0016652860213071108,
0.0012441707076504827,
0.00015699634968768805,
-0.011310374364256859,
0.008230553939938545,
-0.037241045385599136,
0.028485387563705444,
-0.038680654019117355,
0.05498836189508438,
-0.0007415611180476844,
-0.006153740454465151,
-0.032237812876701355,
-0.022573549300432205,
-0.052817147225141525,
0.00484393211081624,
0.03249741345643997,
0.007398648653179407,
0.0396246612071991,
-0.029712596908211708,
0.038727857172489166,
0.012873885221779346,
-0.008873658254742622,
-0.01676791161298752,
0.026974977925419807,
0.014797297306358814,
0.020414134487509727,
0.005991489626467228,
-0.020720936357975006,
0.017983319237828255,
-0.023777157068252563,
-0.004540080204606056,
0.02225494757294655,
-0.031034205108880997,
0.017865318804979324,
0.014112893491983414,
0.022703349590301514,
-0.01353468932211399,
0.023954158648848534,
-0.020425934344530106,
0.048993922770023346,
0.06225721165537834,
0.0788717195391655,
-0.021995345130562782,
0.003351222025230527,
-0.032591816037893295,
-0.06202121078968048,
-0.027399780228734016,
-0.03214341402053833,
0.024709362536668777,
-0.0007319735595956445,
-0.008590457029640675,
0.007717250846326351,
0.02124013938009739,
0.04330628737807274,
-0.0011291200062260032,
0.00752844987437129,
0.047931917011737823,
-0.03245021402835846,
0.02588937059044838,
-0.030916204676032066,
0.02134634181857109,
0.014455095864832401,
0.0022257897071540356,
-0.019009925425052643,
-0.03698144480586052,
0.02983059734106064,
-0.029570994898676872,
0.011977079324424267,
0.017322514206171036,
-0.0265501756221056,
0.00045614675036631525,
0.07367968559265137,
-0.03226141259074211,
0.0691484585404396,
0.042385879904031754,
0.0012898959685117006,
-0.024308159947395325,
-0.04037986695766449,
-0.015528902411460876,
-0.029452994465827942,
0.02027253434062004,
0.013640889897942543,
0.005395585671067238,
0.01163487695157528,
0.04979632794857025,
-0.030208200216293335,
0.0014130593044683337,
-0.013404888100922108,
0.03693424537777901,
-0.007770351134240627,
0.034810230135917664,
-0.012236680835485458,
-0.02355295605957508,
0.058905988931655884,
-0.017405115067958832,
0.031883809715509415,
0.019281327724456787,
-0.047813914716243744,
0.007540249731391668,
-0.022986551746726036,
0.0004166902508586645,
-0.014372495003044605,
0.07854131609201431,
0.03381902351975441,
-0.011581776663661003,
-0.05678197368979454,
-0.009481362998485565,
0.031175805255770683,
0.0035990236792713404,
-0.019611729308962822,
-0.008737958036363125,
0.013794290833175182,
0.0016328358324244618,
0.007351448759436607,
-0.02247914858162403,
0.027163779363036156,
0.036769043654203415,
0.012236680835485458,
-0.028320187702775,
-0.027234580367803574,
0.04179587587714195,
-0.0046934811398386955,
0.005298234988003969,
-0.009888465516269207,
-0.05366675555706024,
-0.007699551060795784,
-0.0306566022336483,
0.007658250629901886,
-0.014042092487215996,
0.022526348009705544,
-0.04736551269888878,
-0.03322901949286461,
0.04007306322455406,
-0.04712951183319092,
0.023718155920505524,
0.01891552470624447,
0.017759116366505623,
-0.0014359219931066036,
0.018950924277305603,
-0.02529936656355858,
-0.010071366094052792,
0.042857881635427475,
0.022821350023150444,
-0.013853291049599648,
0.011770578101277351,
-0.02409575879573822,
0.01664990931749344,
-0.04037986695766449,
-0.021086739376187325,
0.04127667099237442,
0.008177453652024269,
0.033252619206905365,
0.021877344697713852,
0.004492879845201969,
0.03393702581524849,
-0.00641334243118763,
0.005976739339530468,
-0.03544743359088898,
-0.03964826092123985,
-0.03792545199394226,
0.021204739809036255,
0.06315401941537857,
-0.010360468178987503,
0.02153514139354229,
-0.05196754261851311,
0.019352126866579056,
0.005023883190006018,
0.0035223232116550207,
0.00847245566546917,
-0.010572870261967182,
0.005209734197705984,
-0.04729471355676651,
0.005348385311663151,
-0.004171327687799931,
-0.005321835167706013,
0.03646223992109299,
-0.021853744983673096,
0.014573096297681332,
0.012932885438203812,
0.035754237323999405,
0.020886138081550598,
0.05007953196763992,
-0.02099233865737915,
0.030042998492717743,
-0.02428456023335457,
0.0013584839180111885,
-0.02921699360013008,
0.0035695235710591078,
0.01754671521484852,
-0.021015938371419907,
-0.03523503243923187,
-0.03584863618016243,
-0.04618550464510918,
-0.015021499246358871,
-0.001739036524668336,
-0.0025311168283224106,
-0.014726497232913971,
0.007858851924538612,
0.0011357575422152877,
-0.005345435347408056,
0.03978986293077469,
-0.02343495562672615,
-0.004634480457752943,
-0.04349508881568909,
-0.05144834145903587,
-0.019293127581477165,
0.0484275184571743,
-0.009451862424612045,
-0.0020133883226662874,
0.032709814608097076,
-0.012696883641183376,
-0.011510975658893585,
-0.009310261346399784,
0.03030260093510151,
-0.021251941099762917,
-0.04788471758365631,
0.009746864438056946,
-0.008855958469212055,
0.012932885438203812,
-0.017617516219615936,
0.011210073716938496,
0.02570056915283203,
-0.01413649320602417,
-0.038680654019117355,
0.00787655171006918,
-0.009711463935673237,
0.010926872491836548,
-0.03405502438545227,
0.008490156382322311,
-0.004445679485797882,
0.033016618341207504,
-0.029901398345828056,
-0.01192397903650999,
-0.01604810543358326,
-0.007345548365265131,
-0.03943585976958275,
-0.032119810581207275,
0.010478469543159008,
0.0043335785157978535,
-0.02218414656817913,
-0.026290573179721832,
0.02511056512594223,
-0.006106540095061064,
-0.016130706295371056,
-0.022148746997117996,
0.011392975226044655,
-0.027328981086611748,
-0.011440175585448742,
0.02016633376479149,
-0.007203947752714157,
0.03141180798411369,
0.014974298886954784,
-0.006672943942248821,
0.007310148328542709,
-0.0028777439147233963,
-0.0060357400216162205,
-0.022703349590301514,
-0.019186927005648613,
-0.010242467746138573,
0.027777383103966713,
-0.027777383103966713,
0.009982866235077381,
-0.008401655592024326,
-0.015163100324571133,
-0.01192397903650999,
0.016366707161068916,
0.054610759019851685,
-0.009487262926995754,
0.056451573967933655,
0.024496961385011673,
-0.055979568511247635,
0.021145740523934364,
0.009115559980273247,
0.000394933857023716,
-0.03686344251036644,
0.008737958036363125,
0.006808645091950893,
0.008277754299342632,
-0.004469279665499926,
-0.02468576282262802,
0.0009661313961260021,
0.03131740540266037,
0.01115697342902422,
0.006242241244763136,
-0.03306381776928902,
0.012248480692505836,
0.021157540380954742,
0.02463856339454651,
-0.005879388656467199,
-0.005531286355108023,
0.03580143675208092,
0.016366707161068916,
-0.02725818008184433,
-0.035707034170627594,
0.019965732470154762,
-0.013381288386881351,
-0.03346502035856247,
0.00045172174577601254,
-0.014514096081256866,
-0.01563510298728943,
0.004522379953414202,
-0.05225074663758278,
0.010519769042730331,
0.0277301836758852,
0.012248480692505836,
-0.007929651997983456,
-0.02325795404613018,
-0.009569862857460976,
-0.001371021498925984,
0.012614283710718155,
-0.01132807508111,
-0.025912970304489136,
0.024119358509778976,
-0.009304361417889595,
-0.015564302913844585,
0.03417302668094635,
-0.014242693781852722,
0.012331081554293633,
-0.022396547719836235,
-0.06343721598386765,
0.016319507732987404,
-0.030609402805566788,
-0.020425934344530106,
0.004572530277073383,
-0.002764168195426464,
-0.0035459233913570642,
-0.007280648220330477,
-0.030703803524374962,
0.02140534110367298,
-0.014219094067811966,
-0.005540136713534594,
-0.031647808849811554,
0.008885459043085575,
0.023187153041362762,
0.04531230032444,
0.06513643264770508,
-0.028792189434170723,
0.03299301862716675,
-0.011646676808595657,
-0.01521030068397522,
-0.010909171774983406,
0.010502069257199764,
0.0015384351136162877,
-0.0014698471641167998,
0.015705903992056847,
0.017275314778089523,
0.07570929825305939,
0.008932659402489662,
-0.022278547286987305,
-0.022042546421289444,
-0.02987779676914215,
0.010159866884350777,
0.013853291049599648,
-0.026856977492570877,
-0.03608463704586029,
0.024083958938717842,
-0.012449081987142563,
0.005870538763701916,
-0.04653950780630112,
-0.06966765969991684,
-0.04163067415356636,
-0.0020723887719213963,
0.05196754261851311,
-0.028060585260391235,
0.010720370337367058,
-0.010012365877628326,
-0.003894025692716241,
-0.03011379949748516,
-0.012018379755318165,
-0.001964712981134653,
0.017263514921069145,
0.017487715929746628,
-0.01837272197008133,
-0.013652689754962921,
-0.013676290400326252,
-0.018278321251273155,
0.03315822035074234,
0.008378054946660995,
0.06150200590491295,
-0.025865770876407623,
-0.0006014351965859532,
0.014325294643640518,
-0.03023179993033409,
-0.025912970304489136,
0.006006239447742701,
0.015965504571795464,
-0.004073977004736662,
0.016921311616897583,
-0.012862085364758968,
-0.016956711187958717,
-0.02331695333123207,
0.027989784255623817,
0.004663980565965176,
0.07065887004137039,
0.006295341532677412,
0.013192486949265003,
-0.03702864423394203,
0.04281068220734596,
-0.02522856742143631,
-0.010566969402134418,
0.05720677599310875,
0.021605942398309708,
-0.031152205541729927,
0.050976336002349854,
-0.014053892344236374,
-0.017157312482595444,
0.007333748508244753,
-0.004728881176561117,
-0.0205085352063179,
-0.013452088460326195,
-0.015729503706097603,
0.03509343042969704,
-0.014632096514105797,
-0.01028966810554266,
-0.005401485599577427,
-0.0030075449030846357,
0.026644576340913773,
-0.017853517085313797,
-0.04866352304816246,
0.028131386265158653,
-0.016295908018946648,
0.026762576773762703,
0.03466862812638283,
0.02975979633629322,
-0.021959945559501648,
-0.018467122688889503,
0.0015856354730203748,
0.008189254440367222,
-0.006177340634167194,
-0.008254154585301876,
0.004899982362985611,
-0.022172346711158752,
-0.00966426357626915,
-0.000905655964743346,
-0.05069313570857048,
0.003537073265761137,
0.0028644688427448273,
0.01251988299190998,
0.009186360985040665,
0.004781981464475393,
-0.01777091808617115,
0.0004469279374461621,
0.0069325459189713,
0.0003136239538434893,
0.013735290616750717,
-0.020496735349297523,
-0.014478695578873158,
-0.03155340999364853,
0.030019398778676987,
-0.007569749839603901,
0.0041447775438427925,
0.03249741345643997,
0.009569862857460976,
0.015823904424905777,
-0.02862698957324028,
0.020307933911681175,
-0.022797750309109688,
-0.007616950199007988,
0.020661937072873116,
0.019481929019093513,
0.00014823848323430866,
-0.009870764799416065,
-0.003622623858973384,
0.033913422375917435,
-0.026856977492570877,
-0.004979632794857025,
-0.0068145450204610825,
0.028438188135623932,
-0.03738264739513397,
0.0032302713952958584,
0.003068020334467292,
0.006053439807146788,
0.005197934340685606,
-0.08817018568515778,
-0.0026800925843417645,
-0.01574130356311798,
-0.01849072240293026,
-0.0038851755671203136,
0.01503329910337925,
-0.04498189687728882,
-0.012095079757273197,
-0.026290573179721832,
-0.007198047358542681,
0.013286887668073177,
-0.010814771056175232,
0.008124353364109993,
0.021641341969370842,
-0.024968964979052544,
-0.011103873141109943,
0.0006493730470538139,
-0.0527227483689785,
-0.012154079973697662,
0.01849072240293026,
-0.0013850341783836484,
0.01657911017537117,
-0.024166559800505638,
0.05791478231549263,
-0.027234580367803574,
0.017322514206171036,
-0.0082010542973876,
0.002036988502368331,
-0.009681964293122292,
0.011233674362301826,
0.017818117514252663,
0.01778271794319153,
-0.016189707443118095,
0.012696883641183376,
-0.0019484878284856677,
-0.006153740454465151,
0.007687750738114119,
-0.018207520246505737,
-0.009451862424612045,
0.0025886420626193285,
-0.005050433333963156,
0.020024731755256653,
0.023576555773615837,
0.011398875154554844,
0.024591362103819847,
0.02165314368903637,
-0.04970192909240723,
-0.001292846049182117,
0.013782490976154804,
-0.034810230135917664,
0.00936926156282425,
0.011941678822040558,
-0.014549495652318,
0.022160546854138374,
-0.007805751636624336,
0.003026719903573394,
-0.009333861991763115,
0.022408347576856613,
0.022467348724603653,
-0.017664717510342598,
-0.04720031097531319,
0.04937152564525604,
0.05130673944950104,
-0.014266294427216053,
-0.009681964293122292,
-0.011646676808595657,
-0.03929425776004791,
0.04009666293859482,
-0.04269268363714218,
0.01222488097846508,
-0.010384068824350834,
0.007717250846326351,
-0.03811425343155861,
0.038019850850105286,
-0.010755770839750767,
0.007115446962416172,
-0.034739430993795395,
0.0057436879724264145,
-0.043990690261125565,
0.0036373739130795,
-0.03863345459103584,
-0.023340554907917976,
-0.01741691492497921,
-0.01812491938471794,
-0.01085607148706913,
0.021074939519166946,
0.004106427077203989,
0.019127925857901573,
0.018868325278162956,
-0.0025561919901520014,
-0.00611244048923254,
0.006826344877481461,
-0.014785497449338436,
0.008230553939938545,
-0.01980053074657917,
-0.009593463502824306,
-0.02695137821137905,
-0.013770691119134426,
-0.008909058757126331,
-0.0017405115067958832,
0.043093886226415634,
-0.03429102525115013,
0.023458555340766907,
-0.004537129774689674,
0.00648414297029376,
-0.03908185660839081,
0.03077460266649723,
-0.035046231001615524,
-0.014738297089934349,
-0.030255399644374847,
0.028107784688472748,
-0.00042000901885330677,
0.02296295203268528,
-0.024827364832162857,
0.008189254440367222,
0.019422927871346474,
0.045005496591329575,
-0.01849072240293026,
0.03422022610902786,
-0.009192260913550854,
0.08245894312858582,
0.027352580800652504,
0.008283655159175396,
-0.03624983876943588,
-0.02146434225142002,
0.0034692229237407446,
-0.007965052500367165,
0.005141884088516235,
-0.005646337289363146,
0.014443295076489449,
0.020378734916448593,
0.0028202186804264784,
-0.021912744268774986,
-0.025960171595215797,
-0.0010184942511841655,
0.020060133188962936,
0.025063365697860718,
0.004466329701244831,
-0.003392522456124425,
0.005106483586132526,
-0.013487488962709904,
0.028603387996554375,
0.027777383103966713,
0.004649230744689703,
0.02605457231402397,
-0.031883809715509415,
-0.03518783301115036,
0.016354907304048538,
-0.00574073800817132,
0.03370102122426033,
-0.022915750741958618,
0.02343495562672615,
0.009015259332954884,
0.0472475104033947,
-0.005522436462342739,
0.012708683498203754,
0.013959492556750774,
-0.03863345459103584,
-0.03167140856385231,
0.009735064581036568,
-0.014667497016489506,
0.06811004877090454,
-0.01687411218881607,
-0.02815498597919941,
0.021688543260097504,
-0.03919985890388489,
-0.003339421935379505,
0.01267328392714262,
0.016449308022856712,
0.019304927438497543,
0.02695137821137905,
-0.05999159440398216,
0.03990786522626877,
-0.015269300900399685,
-0.03594303876161575,
0.011269074864685535,
-0.0006593293510377407,
0.008112553507089615,
0.005835138726979494,
0.030987003818154335,
-0.03228501230478287,
0.013204286806285381,
0.008844158612191677,
0.010802971199154854,
0.02994859777390957,
-0.010395868681371212,
-0.029547395184636116,
-0.014726497232913971,
0.01368809025734663,
0.008625856600701809,
-0.02188914455473423,
-0.05206194519996643,
0.013924092054367065,
0.05182594060897827,
0.0539027564227581,
-0.033724620938301086,
-0.011121573857963085,
0.029452994465827942,
-0.04498189687728882,
-0.027116579934954643,
-0.04505269601941109,
0.036226239055395126,
0.050126731395721436,
0.0024853914510458708,
-0.022880351170897484,
0.006572643294930458,
0.02647937461733818,
-0.03207261115312576,
-0.016720710322260857,
0.033252619206905365,
-0.006377941928803921,
0.02397775836288929,
-0.02057933621108532,
0.02952379547059536,
0.028414588421583176,
-0.03204901143908501,
0.006726044230163097,
0.004787881392985582,
-0.034810230135917664,
-0.011764677241444588,
-0.02916979230940342,
-0.03783104941248894,
0.01847892254590988,
0.006962046027183533,
0.022833149880170822,
-0.009504962712526321,
0.053053151816129684,
0.025724170729517937,
0.014938898384571075,
0.012189480476081371,
-0.032001812011003494,
0.03355942294001579,
0.021818343549966812,
0.011882678605616093,
-0.011882678605616093,
-0.020473135635256767,
0.001042094430886209,
0.0006866170442663133,
-0.0069030458107590675,
-0.008596356958150864,
0.033252619206905365,
-0.010661370120942593,
-0.01813671924173832,
-0.017676517367362976,
0.005902988836169243,
0.02027253434062004,
0.04443909227848053,
-0.03509343042969704,
-0.006973845884203911,
-0.0084960563108325,
-0.03870425373315811,
0.006667044013738632,
0.04526509717106819,
0.040710270404815674,
0.039813462644815445,
0.013546489179134369,
0.009971065446734428,
0.008407555520534515,
0.04908832535147667,
0.02093333750963211,
-0.03388982266187668,
0.003584273625165224,
-0.012189480476081371,
-0.02015453390777111,
0.025606168434023857,
0.003068020334467292,
0.006478242576122284,
-0.01879752427339554,
0.009422361850738525,
0.013251487165689468,
0.014797297306358814,
0.010596469976007938,
-0.014773697592318058,
-0.004967832937836647,
-0.008543256670236588,
-0.028768589720129967,
0.032898616045713425,
-0.00892085861414671,
0.021546943113207817,
0.012142280116677284,
-0.00996516551822424,
0.0012353206984698772,
-0.014077492989599705,
0.006023939698934555,
0.037783849984407425,
0.02636137418448925,
-0.02069733664393425,
-0.0066375439055264,
0.007894252426922321,
-0.029264193028211594,
-0.02671537548303604,
0.021735742688179016,
-0.006330742035061121,
0.004215577617287636,
-0.01587110571563244,
-0.032237812876701355,
0.006779144983738661,
-0.00505338329821825,
0.009628864005208015,
-0.005020933225750923,
0.0023570656776428223,
0.011882678605616093,
-0.016472909599542618,
-0.0376894474029541,
0.00416247732937336,
-0.007652350701391697,
-0.012885685078799725,
-0.022278547286987305,
0.011369375512003899,
-0.02016633376479149,
-0.050126731395721436,
0.0318366102874279,
0.008625856600701809,
-0.0057082874700427055,
0.0026550174225121737,
0.01130447443574667,
-0.006466442719101906,
0.008867758326232433,
0.00017543397552799433,
-0.002373290713876486,
-0.003590173786506057,
0.0033158219885081053,
-0.018502522259950638,
-0.014396094717085361,
-0.01712191291153431,
-0.013133486732840538,
0.01879752427339554,
0.0007891302229836583,
-0.015092299319803715,
-0.01569410413503647,
0.018655922263860703,
-0.021676743403077126,
-0.0068558454513549805,
0.016555508598685265,
-0.004168377723544836,
0.01505689974874258,
0.017133712768554688,
-0.013098086230456829,
0.013345887884497643,
-0.020956939086318016,
0.0010155441705137491,
0.016154306009411812,
-0.004607930313795805,
-0.009558063000440598,
0.030278999358415604,
-0.0036727741826325655,
0.02027253434062004,
-0.011935778893530369,
-0.03547103330492973,
-0.003678674343973398,
0.050976336002349854,
-0.004722981248050928,
-0.040946271270513535,
0.0229511521756649,
0.014738297089934349,
-0.020213533192873,
-0.0032745215576142073,
-0.0029736196156591177,
-0.003926475998014212,
0.017700117081403732,
-0.007717250846326351,
0.04347148537635803,
0.053005948662757874,
0.0034544728696346283,
0.014844497665762901,
0.0107380710542202,
-0.018585123121738434,
-0.027423381805419922,
0.010378168895840645,
0.02122833952307701,
0.01043716911226511,
0.021676743403077126,
0.011617177166044712,
-0.005469336174428463,
-0.0049707829020917416,
0.013629090040922165,
0.030444201081991196,
0.003483972977846861,
0.016838710755109787,
0.02933499403297901,
-0.012696883641183376,
-0.016661709174513817,
-0.017688317224383354,
-0.0199185311794281,
0.0049176826141774654,
-0.030727403238415718,
-0.032780617475509644,
-0.01133397500962019,
-0.008342655375599861,
-0.02959459461271763,
-0.0008451805915683508,
-0.0241075586527586,
-0.004832131788134575,
0.005059283226728439,
-0.028414588421583176,
-0.0023423153907060623,
0.016413908451795578,
0.02869778871536255,
-0.0016166106797754765,
-0.0030075449030846357,
-0.010094966739416122,
0.0009351561893709004,
-0.017381515353918076,
0.0016623359406366944,
0.01795971766114235,
0.014396094717085361,
0.0020930387545377016,
0.034692227840423584,
0.028367387130856514,
0.02444976195693016,
-0.025865770876407623,
-0.01913972571492195,
-0.06433402746915817,
0.018384521827101707,
-0.012744084000587463,
-0.0074104489758610725,
-0.0033689222764223814,
-0.01670891046524048,
-0.01687411218881607,
-0.0011836952762678266,
0.009404662065207958,
0.015941904857754707,
-0.018101319670677185,
-0.012956485152244568,
0.010909171774983406,
-0.012637883424758911,
0.013003685511648655,
0.0052215345203876495,
-0.007150846999138594,
0.007345548365265131,
0.00831905473023653,
0.004811481572687626,
0.0004690531059168279,
0.006702444050461054,
-0.030208200216293335,
0.003835025243461132,
0.008737958036363125,
0.02480376325547695,
-0.015764903277158737,
0.010472569614648819,
-0.0038202751893550158,
0.012862085364758968,
0.05144834145903587,
0.006029839627444744,
0.01575310342013836,
0.0008223179029300809,
-0.019175127148628235,
-0.0199185311794281,
0.03138820827007294,
0.019824130460619926,
0.02857978828251362,
0.00802405271679163,
-0.0306566022336483,
-0.020803537219762802,
-0.01446689572185278,
0.0035164232831448317,
-0.032237812876701355,
-0.026290573179721832,
0.01587110571563244,
0.014643896371126175,
-0.013758891262114048,
-0.017617516219615936,
-0.0038320752792060375,
0.00641334243118763,
0.012614283710718155,
0.02277415059506893,
-0.00019617629004642367,
0.0036285240203142166,
-0.012413682416081429,
0.006891245488077402,
0.016909511759877205,
0.0349518321454525,
0.028320187702775,
0.009127359837293625,
0.027305379509925842,
-0.024001358076930046,
0.015304701402783394,
0.011392975226044655,
-0.0034810230135917664,
-0.010366368107497692,
-0.04165427386760712,
-0.006495942827314138,
0.0033630221150815487,
-0.013723490759730339,
0.003932375926524401,
0.013015486299991608,
0.00723344786092639,
-0.04014386609196663,
0.007976852357387543,
-0.019529128447175026,
0.013888691551983356,
-0.017558515071868896,
-0.02200714498758316,
-0.02069733664393425,
-0.02313995361328125,
-0.013310488313436508,
-0.015351901762187481,
-0.012720484286546707,
-0.005000283010303974,
0.004469279665499926,
-0.01771191693842411,
-0.01807771995663643,
-0.021098539233207703,
-0.04420309141278267,
0.006254041101783514,
0.013676290400326252,
-0.02952379547059536,
-0.054374758154153824,
-0.01487989816814661,
0.015021499246358871,
-0.020791737362742424,
-0.006956146098673344,
-0.009569862857460976,
0.017605716362595558,
0.029618196189403534,
-0.04200827702879906,
0.0001149585732491687,
0.04266908019781113,
0.026219774037599564,
0.013475689105689526,
0.010401768609881401,
0.018596922978758812,
0.01562330313026905,
-0.032237812876701355,
-0.011540476232767105,
-0.03190740942955017,
0.00611244048923254,
0.03358302265405655,
-0.008732058107852936,
0.026455774903297424,
0.02886299043893814,
-0.01896272599697113,
0.007911952212452888,
0.011564075946807861,
0.00020428885181900114,
0.03761864826083183,
0.01282668486237526,
0.0012515457347035408,
-0.02116934023797512,
-0.006023939698934555,
-0.0035990236792713404,
0.022172346711158752,
0.019540928304195404,
0.009056559763848782,
0.012932885438203812,
0.027871783822774887,
0.05074033513665199,
-0.02994859777390957,
-0.03315822035074234,
0.009015259332954884,
0.05248674750328064,
-0.0009897315176203847,
0.022337546572089195,
0.01428989414125681,
-0.00984126515686512,
-0.05720677599310875,
-0.011835478246212006,
-0.014266294427216053,
-0.026620976626873016,
-0.003221421269699931,
-0.003259771503508091,
-0.006914845667779446,
-0.020119132474064827,
0.015458102338016033,
-0.007717250846326351,
0.0010273442603647709,
-0.025370167568325996,
-0.007516649551689625,
-0.03884585574269295,
0.002103363862261176,
-0.010979972779750824,
-0.009534463286399841,
-0.005209734197705984,
-0.00817155372351408,
-0.025747770443558693,
0.013617290183901787,
-0.027517782524228096,
-0.020673736929893494,
-0.030609402805566788,
-0.01026016753166914,
0.0041034771129488945,
-0.014053892344236374,
-0.03799625113606453,
0.008153853937983513,
-0.005661087576299906,
-0.007298348005861044,
-0.056404370814561844,
0.005422135815024376,
0.00081051787128672,
0.010065466165542603,
-0.02921699360013008,
0.021959945559501648,
-0.009451862424612045,
-0.020909737795591354,
0.017133712768554688,
0.030090197920799255,
0.004265727940946817,
0.0025974921882152557,
-0.02671537548303604,
0.002818743698298931,
-0.03863345459103584,
0.009463662281632423,
0.007422248832881451,
-0.024473361670970917,
0.017865318804979324,
-0.037713050842285156,
-0.03245021402835846,
-0.03143540769815445,
-0.03101060539484024,
-0.020355135202407837,
-0.025842171162366867,
-0.001328983809798956,
0.008702557533979416,
0.0030857203528285027,
0.0003326146979816258,
0.04030906781554222,
-0.02100413851439953,
-0.024591362103819847,
-0.0012308956356719136,
0.003764224937185645,
0.0241075586527586,
0.04358948767185211,
-0.017039312049746513,
-0.0016372607788071036,
0.004283428192138672,
0.0365094393491745,
-0.012331081554293633,
-0.0025030914694070816,
0.016425708308815956,
-0.01353468932211399,
-0.00906245969235897,
0.020779937505722046,
-0.00793555285781622,
-0.030019398778676987,
-0.007357348687946796,
0.006997446063905954,
-0.004180177580565214,
-0.001061269547790289,
-0.031105006113648415,
0.006749644409865141,
-0.020425934344530106,
0.028485387563705444,
0.013924092054367065,
0.019635329023003578,
0.004492879845201969,
0.030680201947689056,
-0.016201507300138474,
-0.028202185407280922,
-0.0004812219412997365,
0.003194871125742793,
-0.022101545706391335,
-0.0012367956805974245,
-0.00550178624689579,
-0.0141600938513875,
0.027305379509925842,
-0.002718443050980568,
0.0051330337300896645,
0.02338775433599949,
-0.02702217921614647,
0.00469643110409379,
0.02975979633629322,
-0.005141884088516235,
-0.0036550741642713547,
0.012283881194889545,
0.018349120393395424,
0.0046256305649876595,
0.018998125568032265,
0.004840982146561146,
-0.007575650233775377,
0.008897258900105953,
-0.03178941085934639,
-0.01574130356311798,
-0.028650589287281036,
0.004572530277073383,
0.13168886303901672,
-0.012390081770718098,
0.008218754082918167,
0.022797750309109688,
0.004171327687799931,
-0.030821803957223892,
0.009953365661203861,
0.0028275935910642147,
0.00804765336215496,
-0.01282668486237526,
0.0322142131626606,
0.0029927948489785194,
0.035282231867313385,
0.021275540813803673,
0.01706291176378727,
-0.021511541679501534,
-0.0010767570929601789,
0.04467509314417839,
-0.022349348291754723,
-0.027399780228734016,
-0.0033423721324652433,
0.020248934626579285,
-0.025511767715215683,
0.003324671881273389,
-0.03643864020705223,
-0.010915071703493595,
-0.010743970982730389,
0.006088840309530497,
0.0048970323987305164,
-0.028367387130856514,
0.025134166702628136,
0.019588129594922066,
-0.007611050270497799,
-0.017452314496040344,
-0.003982526250183582,
-0.006159640848636627,
-0.02063833549618721,
-0.008743857964873314,
0.01237828191369772,
0.005135983694344759,
0.017735516652464867,
-0.00611244048923254,
-0.018632322549819946,
-0.006206841208040714,
0.020921537652611732,
-0.0324266143143177,
-0.026266973465681076,
-0.008360355161130428,
0.0021918644197285175,
-0.028367387130856514,
-0.010714470408856869,
-0.009386962279677391,
0.005675837397575378,
-0.017369715496897697,
-0.02069733664393425,
-0.018927324563264847,
0.012578883208334446,
0.009864864870905876,
0.01192987896502018,
-0.038090649992227554,
-0.03329981863498688,
0.01622510701417923,
0.016260506585240364,
0.01884472370147705,
0.004221478011459112
] | 2024-07-15 | 1 | 39008028 | [
"predictive indicators",
"B lymphocyte",
"Peripheral blood lymphocyte subsets",
"CAR-T cell preparation",
"indicators",
"remarkable efficacy",
"relapsed/refractory acute B-cell lymphoblastic leukaemia",
"CAR-T therapy",
"positive and negative predictive values",
"patients",
"AUC",
"flow cytometry",
"(R/R B",
"the predictive values",
"ROC",
"Chimeric antigen receptor T-cell (CAR-T) therapy",
"accuracy",
"B-MRD",
"Treg",
"specificity",
"receiver operating characteristic (ROC) areas",
"Sensitivity",
"CD3",
"ALL",
"the indicators",
"Fifty-five R/R B-ALL patients",
"22 healthy donors",
"a subset",
"a model",
"AUC 0.936"
] | [
"CAR‐T therapy",
"predictive indicators",
"predictive model",
"relapsed/refractory acute B‐cell lymphoblastic"
] | 0 | 10.1111/sji.13352 | [
"Pu",
"Wang",
"Wu",
"An",
"Xiao",
"Wang",
"Liang",
"Zhai"
] | [
"Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.\nCenter of Hematology Research, Anhui Medical University, Hefei, Anhui, China.",
"Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.\nCenter of Hematology Research, Anhui Medical University, Hefei, Anhui, China.",
"Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.\nCenter of Hematology Research, Anhui Medical University, Hefei, Anhui, China.",
"Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.\nCenter of Hematology Research, Anhui Medical University, Hefei, Anhui, China.",
"Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.\nCenter of Hematology Research, Anhui Medical University, Hefei, Anhui, China.",
"Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.\nCenter of Hematology Research, Anhui Medical University, Hefei, Anhui, China.",
"Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.\nCenter of Hematology Research, Anhui Medical University, Hefei, Anhui, China.",
"Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.\nCenter of Hematology Research, Anhui Medical University, Hefei, Anhui, China."
] | [
"39008028"
] | [] | 6.134063 | 5.402089 |
39007933 | 727 | The role of bone marrow microenvironment on CAR-T efficacy in haematologic malignancies. | In recent years, chimeric antigen receptor-T (CAR-T) cell therapy has emerged as a novel immunotherapy method. It has shown significant therapeutic efficacy in the treatment of haematological B cell malignancies. In particular, the CAR-T therapy targeting CD19 has yielded unprecedented efficacy for acute B-lymphocytic leukaemia (B-ALL) and non-Hodgkin's lymphoma (NHL). In haematologic malignancies, tumour stem cells are more prone to stay in the regulatory bone marrow (BM) microenvironment (called niches), which provides a protective environment against immune attack. However, how the BM microenvironment affects the anti-tumour efficacy of CAR-T cells and its underlying mechanism is worthy of attention. In this review, we discuss the role of the BM microenvironment on the efficacy of CAR-T in haematological malignancies and propose corresponding strategies to enhance the anti-tumour activity of CAR-T therapy. | [
-0.0021016786340624094,
0.027823125943541527,
0.08151306957006454,
0.045864686369895935,
-0.011091210879385471,
-0.03953927010297775,
-0.0017892117612063885,
0.02504081465303898,
-0.015139693394303322,
-0.009172936901450157,
-0.030235912650823593,
0.012911669909954071,
-0.06264550983905792,
0.017378585413098335,
0.03749601170420647,
-0.009118595160543919,
0.03377901390194893,
0.0011391451116651297,
0.04049568995833397,
0.027844863012433052,
0.034365907311439514,
0.016030902042984962,
0.0021505863405764103,
0.016161324456334114,
-0.037126485258340836,
-0.012194355018436909,
0.0011765052331611514,
0.009281621314585209,
-0.016661271452903748,
-0.025953760370612144,
0.008221951313316822,
-0.012118276208639145,
-0.011112947948276997,
-0.0010766517370939255,
-0.0025975496973842382,
0.04443005472421646,
0.03714822232723236,
-0.01780245266854763,
-0.009335963055491447,
-0.04890783876180649,
0.03973490372300148,
0.030844544991850853,
0.01237911731004715,
0.08268685638904572,
-0.07064465433359146,
-0.01458540465682745,
-0.010286948643624783,
-0.06277593225240707,
0.03458327800035477,
0.0167482178658247,
-0.02504081465303898,
0.003931646700948477,
-0.01570485159754753,
0.029366441071033478,
-0.034365907311439514,
0.030279386788606644,
-0.017552480101585388,
0.023562710732221603,
0.01286819577217102,
0.014291957952082157,
-0.014020247384905815,
0.00995002780109644,
-0.020280450582504272,
0.008259990252554417,
-0.05312478169798851,
-0.02375834248960018,
-0.059167616069316864,
-0.04860352352261543,
0.0044968039728701115,
0.019443582743406296,
0.02188897505402565,
-0.028170915320515633,
0.005404316354542971,
-0.003048588754609227,
0.017172085121273994,
-0.009037082083523273,
-0.006678637117147446,
0.007635056972503662,
0.006483005825430155,
0.010683645494282246,
0.0291708093136549,
-0.0035811406560242176,
0.03682217001914978,
-0.05142930895090103,
-0.012400854378938675,
-0.0018951788078993559,
0.02245413325726986,
0.005575493909418583,
-0.03956100717186928,
0.009482686407864094,
0.008221951313316822,
-0.00798828061670065,
-0.05482025444507599,
0.05529846251010895,
0.015248377807438374,
0.039104536175727844,
-0.026518916711211205,
-0.0847301185131073,
0.03493106737732887,
0.05064678564667702,
0.052863940596580505,
0.0013762122252956033,
-0.00028325789025984704,
-0.022062869742512703,
0.06590603291988373,
-0.002211721148341894,
-0.05708088353276253,
-0.007814385928213596,
0.009374002926051617,
-0.011987854726612568,
0.03254001587629318,
-0.025540759786963463,
0.0006235749460756779,
0.048125315457582474,
-0.042821530252695084,
-0.040560901165008545,
0.012509538792073727,
0.007765477988868952,
0.00795024074614048,
0.029714230448007584,
0.00033182610059157014,
0.036430906504392624,
0.02734491601586342,
-0.02823612652719021,
-0.0037224299740046263,
-0.002484790049493313,
0.08268685638904572,
-0.018095901235938072,
-0.013781142421066761,
-0.0759049654006958,
0.036322221159935,
0.015107087790966034,
0.018563242629170418,
-0.019769635051488876,
-0.08007843792438507,
-0.0012811137130483985,
-0.03280085697770119,
-0.022367184981703758,
-0.03395291045308113,
-0.03608311712741852,
0.006129782646894455,
0.006569953169673681,
-0.02362792007625103,
-0.007673096377402544,
-0.04747321084141731,
-0.022367184981703758,
0.023519236594438553,
0.01075972430408001,
-0.005662440788000822,
0.039430588483810425,
-0.005722217261791229,
0.040560901165008545,
0.02621460147202015,
0.015922218561172485,
0.012226959690451622,
-0.024345235899090767,
0.014085457660257816,
0.07438339293003082,
-0.046994999051094055,
-0.058776356279850006,
-0.007635056972503662,
0.010678211227059364,
-0.032953016459941864,
-0.03588748723268509,
0.022280238568782806,
0.002145152073353529,
-0.02160639688372612,
0.03545274958014488,
-0.04842963069677353,
-0.00010452352580614388,
-0.03947405889630318,
-0.03099670261144638,
-0.0641670823097229,
-0.019161004573106766,
-0.0352136455476284,
0.0021641720086336136,
0.03458327800035477,
-0.012618222273886204,
-0.017704637721180916,
-0.010531487874686718,
0.020323924720287323,
0.03771337866783142,
0.03227917477488518,
-0.010058712214231491,
-0.02841002121567726,
0.02541033923625946,
-0.001271603861823678,
0.019965266808867455,
-0.05116846784949303,
0.0020025044213980436,
-0.005154342856258154,
-0.0233453419059515,
0.031170597299933434,
0.012389985844492912,
-0.005075546912848949,
-0.00795024074614048,
0.033279068768024445,
0.04160426929593086,
-0.03697432577610016,
-0.001848988002166152,
0.04899478703737259,
-0.018628451973199844,
-0.034539803862571716,
0.009238147176802158,
-0.01805242709815502,
0.00827629305422306,
-0.018911032006144524,
0.03888716548681259,
0.004129995126277208,
0.01404198445379734,
0.021997658535838127,
-0.0001774607371771708,
-0.040647849440574646,
0.018704531714320183,
-0.039669692516326904,
-0.006569953169673681,
-0.01918274164199829,
0.04899478703737259,
0.0035077789798378944,
0.016530849039554596,
0.01909579336643219,
-0.01833500526845455,
0.004779382608830929,
0.01982397772371769,
-0.059906668961048126,
-0.0025133194867521524,
0.02419307827949524,
-0.02254107967019081,
-0.016574323177337646,
-0.00375231821089983,
0.011433565989136696,
0.02264976315200329,
0.034496329724788666,
-0.028866494074463844,
-0.007472030818462372,
-0.003236068645492196,
-0.008787108585238457,
0.023084500804543495,
0.0497773140668869,
-0.024823445826768875,
0.007531807292252779,
0.022932343184947968,
0.034170277416706085,
-0.036517854779958725,
-0.0027565001510083675,
-0.013520300388336182,
0.005434204358607531,
-0.058689408004283905,
0.016324350610375404,
-0.005034790374338627,
-0.01625913940370083,
0.026279812678694725,
-0.04166948050260544,
-0.0031110821291804314,
0.018519768491387367,
0.027823125943541527,
0.01582440361380577,
-0.016400428488850594,
0.0381263792514801,
-0.028453493490815163,
-0.004510389640927315,
0.01124880276620388,
-0.008080662228167057,
-0.055820148438215256,
-0.04747321084141731,
-0.01102600060403347,
-0.02504081465303898,
0.005776559468358755,
0.07420949637889862,
0.002168247476220131,
0.023780077695846558,
0.010047843679785728,
0.02504081465303898,
-0.04490826651453972,
-0.025758128613233566,
0.010694514028728008,
-0.004200640134513378,
0.005852638278156519,
0.014009378850460052,
0.026279812678694725,
0.018465425819158554,
0.03532232716679573,
0.030453281477093697,
-0.014052852988243103,
-0.0321270152926445,
-0.043560583144426346,
-0.0005159098072908819,
0.0008409431320615113,
0.012509538792073727,
-0.004735908936709166,
0.016596060246229172,
-0.0032876937184482813,
-0.026388496160507202,
-0.009694620966911316,
-0.004765797406435013,
-0.023149710148572922,
0.020606502890586853,
-0.019671820104122162,
-0.053472571074962616,
0.03193138539791107,
-0.022519342601299286,
-0.006118914112448692,
-0.04406052827835083,
-0.03697432577610016,
0.03330080583691597,
-0.008004583418369293,
-0.013531168922781944,
-0.020823871716856956,
0.019856583327054977,
0.039387114346027374,
0.014335431158542633,
-0.014411509968340397,
0.014552799053490162,
-0.003073042491450906,
0.007222057785838842,
0.0006541423499584198,
-0.000137808034196496,
-0.07486160099506378,
-0.010411935858428478,
-0.03423548862338066,
-0.04162600636482239,
-0.006504742428660393,
-0.05651572719216347,
0.00966744963079691,
0.012759512290358543,
-0.009047950617969036,
0.012716038152575493,
0.011574855074286461,
0.0018544222693890333,
-0.037648167461156845,
-0.006347150541841984,
-0.03947405889630318,
0.05621141195297241,
-0.005469526629894972,
0.007173149846494198,
0.011563986539840698,
-0.01512882485985756,
-0.06016751006245613,
0.03758295625448227,
0.011172723956406116,
0.0262580756098032,
0.06021098420023918,
-0.0025404905900359154,
0.06190645694732666,
0.0009095499408431351,
-0.037691641598939896,
0.023367078974843025,
0.008825147524476051,
-0.009037082083523273,
0.0366700105369091,
0.00793393887579441,
-0.0040539163164794445,
0.02897517755627632,
-0.0035159301478415728,
-0.030170703306794167,
0.02099776640534401,
-0.0334094874560833,
-0.0033610553946346045,
0.018965372815728188,
-0.013150774873793125,
0.026171129196882248,
-0.013074696063995361,
-0.03369206562638283,
0.042865004390478134,
0.07212276011705399,
0.09155547618865967,
0.0005617608549073339,
0.006423229817301035,
-0.036517854779958725,
-0.02456260472536087,
-0.04179989919066429,
-0.005939585622400045,
0.03314864635467529,
0.006656900513917208,
-0.02205200120806694,
0.0424954779446125,
0.02560597099363804,
0.017248164862394333,
-0.00540159922093153,
-0.0009740811656229198,
0.030192440375685692,
-0.004200640134513378,
0.011813960038125515,
0.0018829518230631948,
-0.015248377807438374,
0.030779333785176277,
0.013955037109553814,
-0.03936537727713585,
-0.07468770444393158,
0.036561328917741776,
-0.001048122183419764,
-0.016530849039554596,
0.009270752780139446,
0.0017579650739207864,
-0.004287587478756905,
0.07247055321931839,
-0.02055216021835804,
0.06603645533323288,
0.055168043822050095,
0.010737988166511059,
0.006640597712248564,
-0.046994999051094055,
-0.004499521106481552,
-0.03734385222196579,
0.027453601360321045,
-0.028149178251624107,
0.018563242629170418,
-0.0028067666571587324,
0.03119233250617981,
-0.04390837252140045,
-0.015259246341884136,
0.03467022255063057,
0.040278322994709015,
0.015791798010468483,
0.028823019936680794,
-0.011596592143177986,
-0.049429524689912796,
0.026844969019293785,
-0.03234438598155975,
0.05255962535738945,
0.03308343514800072,
-0.025106023997068405,
0.020280450582504272,
0.009053384885191917,
-0.01122706662863493,
0.009357700124382973,
0.06512350589036942,
0.020823871716856956,
-0.010531487874686718,
-0.04542994871735573,
-0.03156185895204544,
0.05177709832787514,
-0.0005220232415013015,
-0.014118063263595104,
-0.01355290599167347,
0.013792010955512524,
-0.0497773140668869,
0.006705808453261852,
-0.0352136455476284,
0.005792861804366112,
-0.005140757188200951,
-0.00902077928185463,
-0.020584765821695328,
-0.004415290895849466,
0.043756213039159775,
0.017693769186735153,
0.02225850149989128,
0.017454665154218674,
-0.029670756310224533,
-0.03766990453004837,
-0.001313718967139721,
-0.012531274929642677,
-0.0018938202410936356,
0.015998298302292824,
-0.030561964958906174,
0.009047950617969036,
0.04921215400099754,
-0.04825573414564133,
-0.005393447820097208,
0.01570485159754753,
0.019715294241905212,
-0.04712542146444321,
0.040930427610874176,
-0.02104123868048191,
0.007553543895483017,
0.037930745631456375,
0.03775685280561447,
-0.021052107214927673,
0.013335537165403366,
-0.03556143492460251,
0.03490933030843735,
0.0004982486134395003,
0.00019580117077566683,
0.030844544991850853,
-0.015096220187842846,
0.04251721501350403,
-0.001884310389868915,
0.01486798282712698,
0.021345555782318115,
-0.006292808800935745,
-0.011107513681054115,
-0.04110432043671608,
-0.052820466458797455,
-0.03895237669348717,
0.012292169965803623,
0.015117956325411797,
-0.00993372593075037,
0.003154555568471551,
-0.014226746745407581,
0.025540759786963463,
0.001044046483002603,
-0.0032496543135493994,
-0.00397512037307024,
-0.00795024074614048,
0.007499202154576778,
-0.019237084314227104,
-0.0205195564776659,
-0.004129995126277208,
-0.006700374186038971,
0.025910286232829094,
-0.0323009118437767,
0.0131290378049016,
0.019639214500784874,
0.01106404047459364,
0.01031411997973919,
0.035387538373470306,
-0.02804049476981163,
0.035865750163793564,
0.012031328864395618,
-0.015683114528656006,
-0.03338775038719177,
-0.028105705976486206,
0.038778483867645264,
-0.026127655059099197,
-0.04747321084141731,
-0.04773405194282532,
-0.05299436300992966,
-0.023475762456655502,
-0.007510070689022541,
-0.0013300215359777212,
-0.005955887958407402,
0.016215665265917778,
-0.019193610176444054,
-0.011542250402271748,
0.028670862317085266,
0.003116516163572669,
-0.012042197398841381,
-0.02621460147202015,
-0.03873500972986221,
-0.03588748723268509,
0.030801070854067802,
-0.02832307294011116,
-0.016606928780674934,
0.010705382563173771,
-0.013694195076823235,
-0.03553969785571098,
-0.017367716878652573,
0.029475124552845955,
-0.022910606116056442,
-0.0394088514149189,
0.02973596565425396,
-0.004363666288554668,
0.0011934870854020119,
-0.002700799610465765,
0.0054803951643407345,
0.02022610791027546,
-0.026323286816477776,
-0.013607247732579708,
0.03369206562638283,
-0.01934576779603958,
0.010569527745246887,
-0.047038473188877106,
0.01695471815764904,
0.009178371168673038,
0.02869259938597679,
-0.024366972967982292,
-0.010890145786106586,
-0.02330186776816845,
-0.0026287962682545185,
-0.004445179365575314,
-0.0467776320874691,
0.014270220883190632,
0.010058712214231491,
-0.0033501870930194855,
-0.05677656829357147,
0.03054022789001465,
-0.02577986568212509,
-0.013248590752482414,
-0.024453919380903244,
0.013596379198133945,
-0.0024521846789866686,
0.013857221230864525,
0.0033855093643069267,
-0.026171129196882248,
0.025910286232829094,
-0.009694620966911316,
0.008955569006502628,
0.03345296159386635,
-0.012889932841062546,
0.02864912524819374,
-0.028062231838703156,
-0.023149710148572922,
-0.027214495465159416,
0.01860671676695347,
-0.008852318860590458,
0.027171021327376366,
-0.039387114346027374,
-0.007569846697151661,
-0.014672352001070976,
-0.016498245298862457,
0.04860352352261543,
-0.012129143811762333,
0.052211835980415344,
0.03545274958014488,
-0.039626218378543854,
0.026649339124560356,
-0.0008490944164805114,
0.00011012754839612171,
-0.014302825555205345,
0.00475492887198925,
-0.021139055490493774,
-0.0057493881322443485,
-0.01355290599167347,
-0.025714654475450516,
-0.006548216100782156,
0.019650083035230637,
0.023693131282925606,
0.00021448126062750816,
0.0117161450907588,
0.0175198744982481,
0.04808184131979942,
0.05477678030729294,
-0.023932235315442085,
-0.0025214708875864744,
0.028909968212246895,
0.014954930171370506,
-0.014607141725718975,
-0.01371593214571476,
0.015324456617236137,
-0.018682794645428658,
-0.015520087443292141,
-0.008765371516346931,
-0.016519980505108833,
-0.010547790676355362,
-0.006781887263059616,
-0.05608098953962326,
-0.010020673274993896,
0.007678530644625425,
0.014987535774707794,
0.0035648380871862173,
-0.016193928197026253,
-0.020486950874328613,
-0.0277579165995121,
0.012455196119844913,
-0.004170751664787531,
-0.01059669815003872,
0.04099563881754875,
-0.01252040732651949,
-0.0025866813957691193,
0.012955143116414547,
-0.011987854726612568,
-0.002503809751942754,
-0.02564944513142109,
-0.034365907311439514,
0.008732766844332218,
-0.01970442570745945,
-0.054515939205884933,
-0.004426159430295229,
0.012063933536410332,
-0.018258927389979362,
-0.014607141725718975,
-0.02419307827949524,
0.025475550442934036,
-0.015465745702385902,
0.01187917124480009,
-0.017867663875222206,
0.001733511220663786,
0.00394523236900568,
0.08107832819223404,
0.06960128992795944,
-0.009433778934180737,
0.01667213998734951,
0.0008042622357606888,
-0.029475124552845955,
-0.004187054466456175,
-0.014074589125812054,
0.0174764022231102,
-0.017585085704922676,
0.013465958647429943,
-0.007238360121846199,
0.08603432029485703,
0.01930229365825653,
-0.022628027945756912,
-0.016117850318551064,
0.0005366276600398123,
0.0159765612334013,
0.006276505999267101,
-0.004578317049890757,
-0.03782206401228905,
0.008901226334273815,
-0.008042622357606888,
0.005181513726711273,
-0.023171447217464447,
-0.05886330083012581,
-0.0033800750970840454,
0.010553224943578243,
0.03508322313427925,
0.004382685758173466,
0.009515292011201382,
-0.018302399665117264,
0.012487801723182201,
-0.03682217001914978,
-0.03977837786078453,
0.0030893452931195498,
0.02577986568212509,
0.010161962360143661,
-0.006586255505681038,
0.011036869138479233,
-0.017509005963802338,
-0.029909860342741013,
0.022432396188378334,
0.010873842984437943,
0.06747107952833176,
-0.018802346661686897,
0.019084926694631577,
-0.0233453419059515,
0.015650508925318718,
-0.01942184567451477,
0.0014169687638059258,
0.01015652809292078,
-0.0009734018822200596,
-0.0074611627496778965,
-0.017693769186735153,
-0.0291708093136549,
-0.01345509011298418,
0.025671182200312614,
-0.0012260923394933343,
0.037974219769239426,
0.005733085796236992,
0.01627000793814659,
-0.018074164167046547,
0.02832307294011116,
-0.026171129196882248,
-0.010009804740548134,
0.05090762674808502,
0.039104536175727844,
-0.04721236601471901,
0.03553969785571098,
-0.026758022606372833,
-0.008890358731150627,
-0.017585085704922676,
-0.02751881070435047,
-0.00702099222689867,
-0.017422059550881386,
-0.0024712043814361095,
0.03275738283991814,
-0.0041680349968373775,
-0.04175642505288124,
-0.019400110468268394,
-0.0007431274279952049,
0.017585085704922676,
-0.009901120327413082,
-0.03423548862338066,
0.014346299692988396,
0.0050538103096187115,
0.017259033396840096,
0.025714654475450516,
-0.017019927501678467,
-0.023736605420708656,
-0.029801176860928535,
-0.004434310831129551,
0.005455941427499056,
-0.011400960385799408,
0.013487695716321468,
0.005651572719216347,
-0.04025658592581749,
-0.005733085796236992,
-0.0007560336962342262,
-0.055863622575998306,
-0.010553224943578243,
-0.021062975749373436,
0.009759831242263317,
-0.012933406047523022,
-0.02128034457564354,
-0.012933406047523022,
-0.0046027712523937225,
0.019715294241905212,
0.010455409064888954,
0.002272855956107378,
-0.011477040126919746,
-0.00918380543589592,
-0.026105917990207672,
0.021302081644535065,
-0.01598742976784706,
0.0029806611128151417,
0.03297475352883339,
0.0067547159269452095,
0.022801920771598816,
0.01711774431169033,
0.011498776264488697,
-0.01991092413663864,
-0.01059669815003872,
0.009200108237564564,
0.02888823114335537,
-0.0043392120860517025,
0.004415290895849466,
0.005002185236662626,
-0.012140012346208096,
-0.031148860231041908,
-0.0012165824882686138,
-0.01703079603612423,
0.01881321519613266,
-0.044082265347242355,
0.010846671648323536,
-0.019769635051488876,
0.03227917477488518,
0.03682217001914978,
-0.05995014309883118,
0.006515610963106155,
-0.0009998936438933015,
-0.004097389988601208,
-0.007156847044825554,
0.009819607250392437,
-0.04964689165353775,
-0.003390943631529808,
0.007961109280586243,
-0.011314013972878456,
0.011531381867825985,
0.0009081914322450757,
0.005901545751839876,
0.01820458471775055,
-0.0016275441739708185,
-0.021595528349280357,
-0.01728077046573162,
-0.03901758790016174,
-0.0021560206077992916,
0.04486479237675667,
0.005205967929214239,
0.012900801375508308,
-0.03484411910176277,
0.06290634721517563,
-0.02662760205566883,
0.01512882485985756,
-0.0009183805668726563,
-0.010123922489583492,
-0.04090869054198265,
-0.018237190321087837,
0.012629090808331966,
0.03156185895204544,
-0.0321270152926445,
0.02375834248960018,
-0.026105917990207672,
-0.024671288207173347,
0.03514843434095383,
0.008281727321445942,
-0.030453281477093697,
0.007385083939880133,
0.0011309938272461295,
0.03001854568719864,
0.02560597099363804,
0.023410553112626076,
-0.021291213110089302,
-0.0051733627915382385,
-0.03953927010297775,
-0.009493554942309856,
0.016074376180768013,
-0.01303122192621231,
0.004741343203932047,
-0.020736923441290855,
-0.024453919380903244,
0.01367245800793171,
0.01286819577217102,
-0.02710581198334694,
-0.026323286816477776,
0.03873500972986221,
0.01711774431169033,
0.019595740363001823,
-0.016889506950974464,
0.05316825583577156,
0.030127229169011116,
-0.01484624668955803,
-0.014389772899448872,
-0.022562816739082336,
-0.0555158331990242,
0.015639640390872955,
-0.04030006006360054,
0.007640491239726543,
-0.021921580657362938,
0.012031328864395618,
-0.020497819408774376,
0.03458327800035477,
-0.0076187546364963055,
0.0047820997424423695,
-0.0379524827003479,
-0.007923070341348648,
-0.025214707478880882,
-0.00310564786195755,
-0.04673415794968605,
-0.0408652164041996,
-0.036191802471876144,
0.010797764174640179,
-0.03275738283991814,
-0.008542569354176521,
0.008629516698420048,
0.022345447912812233,
-0.0009292489266954362,
-0.005219553131610155,
-0.019965266808867455,
-0.02443218231201172,
-0.023519236594438553,
-0.0005770445568487048,
-0.024084394797682762,
-0.015096220187842846,
-0.012107407674193382,
0.019976135343313217,
0.014770167879760265,
-0.024584339931607246,
0.04193032160401344,
-0.04955994337797165,
0.024627814069390297,
-0.01695471815764904,
0.004532126244157553,
-0.012248696759343147,
0.02747533656656742,
-0.014389772899448872,
-0.0013436070876196027,
-0.024258287623524666,
0.055081095546483994,
-0.025345129892230034,
0.015585298649966717,
-0.03343122452497482,
0.0027211778797209263,
0.004067501984536648,
0.03140970319509506,
0.003697976004332304,
0.0032768251840025187,
-0.007385083939880133,
0.06394971907138824,
0.006510176695883274,
0.017182953655719757,
-0.02884475700557232,
-0.0013551546726375818,
-0.011922644451260567,
-0.006798189599066973,
0.018878426402807236,
-0.0064558349549770355,
0.021454239264130592,
0.005705914460122585,
-0.011846565641462803,
0.006227598059922457,
-0.011640065349638462,
-0.025475550442934036,
0.019106661900877953,
0.02080213464796543,
0.022475868463516235,
0.022073738276958466,
0.015433140099048615,
0.008884924463927746,
-0.006944913417100906,
0.0020663561299443245,
0.010694514028728008,
0.04921215400099754,
-0.014531062915921211,
-0.01731337606906891,
0.02888823114335537,
0.0026953653432428837,
0.007200320716947317,
-0.018258927389979362,
0.027975283563137054,
0.03467022255063057,
0.06273245811462402,
0.010645606555044651,
-0.0025785299949347973,
0.02888823114335537,
-0.033605121076107025,
-0.02573639154434204,
0.022182421758770943,
-0.04419095069169998,
0.04847310483455658,
-0.03897411376237869,
-0.017009058967232704,
0.010651040822267532,
-0.0029181677382439375,
-0.0022932342253625393,
0.00009450421202927828,
0.012346512638032436,
0.013759405352175236,
0.017552480101585388,
-0.04179989919066429,
0.03897411376237869,
-0.004159883596003056,
0.0017185671022161841,
0.0011459378292784095,
0.011792223900556564,
-0.013824615627527237,
0.03401811793446541,
0.026323286816477776,
-0.03234438598155975,
-0.014618010260164738,
-0.0008511322666890919,
0.015400535427033901,
0.021954186260700226,
-0.03217048943042755,
-0.02031305618584156,
-0.0027143850456923246,
0.0012634525774046779,
-0.00967288389801979,
-0.03969142958521843,
-0.02230197563767433,
0.01707427017390728,
0.038865428417921066,
0.04414747655391693,
-0.03832200914621353,
-0.03625700995326042,
0.022030264139175415,
-0.02451913058757782,
-0.02588854916393757,
-0.036756958812475204,
0.018345873802900314,
0.025823339819908142,
-0.006010230164974928,
-0.013770273886620998,
-0.012118276208639145,
-0.005447790026664734,
-0.022084606811404228,
0.005961322225630283,
0.04071306064724922,
-0.00993372593075037,
0.05316825583577156,
-0.044038791209459305,
0.02780138887465,
0.029518598690629005,
0.018019821494817734,
0.020400002598762512,
-0.018563242629170418,
-0.01613958738744259,
0.00021821727568749338,
-0.04382142424583435,
-0.05421162396669388,
0.02893170341849327,
-0.009015345014631748,
-0.001456366735510528,
0.00827085878700018,
0.05264657363295555,
0.04856004938483238,
-0.0051733627915382385,
0.006863400340080261,
-0.034126803278923035,
0.029583808034658432,
0.03743080049753189,
-0.005879809148609638,
0.003977837506681681,
0.0037767719477415085,
-0.01711774431169033,
-0.013465958647429943,
0.008672989904880524,
0.006841663271188736,
0.045908160507678986,
0.0219324491918087,
0.001174467382952571,
-0.05186404660344124,
-0.013215985149145126,
0.0050375075079500675,
0.03762643039226532,
-0.049255628138780594,
-0.021106449887156487,
-0.023454025387763977,
-0.030931491404771805,
0.019291425123810768,
0.024953866377472878,
0.020573897287249565,
0.031040174886584282,
0.019834846258163452,
0.014400641433894634,
0.021345555782318115,
0.035104960203170776,
0.022073738276958466,
0.0063362824730575085,
0.000013691647836822085,
-0.040843479335308075,
-0.004629942122846842,
-0.0010046485112980008,
0.019476188346743584,
0.010004370473325253,
-0.01216174941509962,
0.005377145018428564,
0.039430588483810425,
0.014128931798040867,
0.015270113945007324,
-0.015085351653397083,
-0.004379968624562025,
0.0035322329495102167,
-0.01873713731765747,
0.0004248868499416858,
-0.004589185584336519,
-0.021943317726254463,
0.0026899310760200024,
0.011683539487421513,
-0.0074448599480092525,
-0.010134791024029255,
-0.010901014320552349,
0.0248451828956604,
0.024714762344956398,
-0.029931597411632538,
-0.014922325499355793,
0.00523857306689024,
-0.018541505560278893,
-0.04245200380682945,
0.007971977815032005,
-0.019237084314227104,
-0.011444434523582458,
0.011748749762773514,
-0.028127441182732582,
-0.011455303058028221,
0.006803623866289854,
-0.007732872851192951,
-0.027497073635458946,
-0.008265424519777298,
0.03262696415185928,
-0.01371593214571476,
-0.03369206562638283,
-0.0007139185909181833,
-0.004113692790269852,
-0.02691018022596836,
-0.03467022255063057,
0.00634171674028039,
-0.012922538444399834,
-0.039669692516326904,
0.022671500220894814,
0.0037468839436769485,
-0.01800895296037197,
-0.0008164892205968499,
0.003896324662491679,
-0.005485829431563616,
0.007477465085685253,
0.023280130699276924,
-0.003179009538143873,
0.010868408717215061,
0.01031955424696207,
-0.00793393887579441,
-0.001502557541243732,
-0.019997872412204742,
0.015846140682697296,
-0.003961535170674324,
-0.0009734018822200596,
-0.02832307294011116,
-0.016411297023296356,
0.013846352696418762,
-0.0098956860601902,
0.02358444780111313,
-0.012172617949545383,
0.002885562600567937,
0.010558659210801125,
0.008602345362305641,
-0.0005257593002170324,
0.01258561760187149,
-0.005510283168405294,
-0.008977306075394154,
0.009379437193274498,
0.011303145438432693,
0.013063827529549599,
0.022062869742512703,
0.005447790026664734,
-0.016802560538053513,
-0.02423655241727829,
0.0020514121279120445,
-0.009156634099781513,
0.05434204265475273,
-0.02362792007625103,
-0.04712542146444321,
0.021226001903414726,
0.02751881070435047,
0.00439898855984211,
0.00977069977670908,
-0.0028529572300612926,
-0.013781142421066761,
0.02601896971464157,
-0.01199872326105833,
0.03325733169913292,
0.03382248803973198,
-0.03219222649931908,
0.0037197128403931856,
0.018106769770383835,
-0.009602239355444908,
-0.01954139955341816,
-0.014237615279853344,
0.015085351653397083,
0.007450294215232134,
0.005224987398833036,
-0.03197485953569412,
-0.004132712259888649,
0.003942515235394239,
0.009825041517615318,
0.040278322994709015,
0.021182529628276825,
-0.014976667240262032,
0.043995317071676254,
-0.017063401639461517,
-0.013237722218036652,
-0.02447565644979477,
-0.0247582346200943,
-0.004665264394134283,
-0.013422484509646893,
-0.020823871716856956,
-0.01486798282712698,
0.018226321786642075,
0.002669552806764841,
0.009210976772010326,
0.022801920771598816,
0.003048588754609227,
-0.017248164862394333,
-0.01949792541563511,
-0.03164880722761154,
-0.005733085796236992,
0.007917636074125767,
-0.014813641086220741,
0.015574430115520954,
-0.009433778934180737,
-0.018965372815728188,
0.017226427793502808,
0.011053171940147877,
-0.005570059642195702,
0.03343122452497482,
0.006814492400735617,
0.009531594812870026,
0.022932343184947968,
0.014052852988243103,
-0.03119233250617981,
-0.029627282172441483,
-0.06055877357721329,
0.020823871716856956,
-0.02597549743950367,
-0.006086308974772692,
0.028627388179302216,
-0.014531062915921211,
-0.04729931429028511,
-0.006798189599066973,
0.0004985882551409304,
-0.009825041517615318,
0.01691124401986599,
-0.019574005156755447,
-0.007885030470788479,
-0.02432349883019924,
0.013335537165403366,
0.007357912603765726,
-0.02414960414171219,
0.002742914715781808,
-0.003977837506681681,
0.014672352001070976,
0.016411297023296356,
0.023214921355247498,
-0.02512776106595993,
0.011770486831665039,
0.00009645712998462841,
0.009335963055491447,
0.00000958415330387652,
0.0071840183809399605,
-0.005434204358607531,
0.013694195076823235,
0.05973277613520622,
0.025671182200312614,
0.033887699246406555,
-0.018226321786642075,
-0.027301443740725517,
-0.004646244924515486,
0.03545274958014488,
0.004254981875419617,
0.0364961177110672,
0.033192120492458344,
-0.034365907311439514,
-0.028496967628598213,
-0.015052746050059795,
-0.018921900540590286,
-0.011498776264488697,
0.003486042143777013,
-0.0028094835579395294,
0.02973596565425396,
-0.05499414727091789,
-0.004170751664787531,
-0.007548110093921423,
0.004950560163706541,
0.024062657728791237,
-0.006031966768205166,
-0.02893170341849327,
0.015367929823696613,
-0.020410871133208275,
0.008145872503519058,
0.028388284146785736,
0.026714548468589783,
0.022910606116056442,
0.02560597099363804,
0.005159777123481035,
-0.028779545798897743,
0.033279068768024445,
0.012509538792073727,
0.01268343348056078,
0.0034045290667563677,
-0.02367139421403408,
0.027171021327376366,
-0.011422697454690933,
-0.009841344319283962,
0.0067547159269452095,
0.013770273886620998,
0.000423867953941226,
-0.0015161429764702916,
0.018791478127241135,
-0.02404092065989971,
0.01470495667308569,
-0.006417795550078154,
-0.007281833793967962,
-0.030931491404771805,
-0.0063199796713888645,
-0.014509325847029686,
-0.007558978162705898,
-0.003070325590670109,
0.022280238568782806,
-0.008455622009932995,
-0.004184337332844734,
-0.007645925506949425,
0.005042941775172949,
-0.017693769186735153,
0.000635801930911839,
-0.006379756145179272,
-0.04127821698784828,
-0.06938391923904419,
-0.005977625027298927,
0.015041877515614033,
-0.02601896971464157,
0.006716676522046328,
-0.02306276373565197,
0.013759405352175236,
0.02573639154434204,
-0.041691217571496964,
-0.001251904875971377,
0.041495583951473236,
0.007591583766043186,
0.0013476826716214418,
-0.0006724827690050006,
0.03532232716679573,
-0.00033233556314371526,
-0.03573532775044441,
0.00029599430854432285,
-0.031909648329019547,
0.008651253767311573,
0.02588854916393757,
-0.031453173607587814,
0.010949921794235706,
0.04160426929593086,
-0.00017678146832622588,
0.026997126638889313,
-0.016639534384012222,
-0.008950134739279747,
0.044647421687841415,
0.004200640134513378,
-0.013857221230864525,
-0.008037188090384007,
-0.0010488014668226242,
-0.03873500972986221,
0.003494193311780691,
0.016052639111876488,
-0.014661483466625214,
-0.012607353739440441,
-0.021410765126347542,
0.030888017266988754,
-0.025627708062529564,
-0.00821108277887106,
0.01740032248198986,
0.06351497769355774,
-0.0015283699613064528,
0.0017076986841857433,
0.0035322329495102167,
-0.011216198094189167,
-0.01679169200360775,
-0.0008069793693721294,
0.012759512290358543,
-0.019117530435323715,
-0.0038773047272115946,
-0.0033610553946346045,
-0.0131290378049016,
0.005640704184770584,
0.014400641433894634,
0.01432456262409687,
0.0003070325474254787,
-0.033757276833057404,
0.0010651040356606245,
-0.030757596716284752,
-0.00045783171663060784,
-0.018595848232507706,
-0.03930016607046127,
-0.013096432201564312,
0.004619073588401079,
-0.012922538444399834,
0.021878106519579887,
-0.004931540694087744,
0.0075807152315974236,
0.0019848430529236794,
-0.04208247736096382,
0.010123922489583492,
0.0019794090185314417,
-0.03251827880740166,
0.003035003086552024,
0.006901439744979143,
-0.013705063611268997,
-0.011400960385799408,
-0.011585723608732224,
-0.015215772204101086,
0.011737881228327751,
-0.04664720967411995,
0.008238254114985466,
-0.0067329793237149715,
-0.01458540465682745,
0.02719275839626789,
0.039343640208244324,
-0.031170597299933434,
-0.004844593349844217,
-0.025758128613233566,
0.002877411199733615,
-0.009884817525744438,
0.036583062261343,
-0.0033610553946346045,
-0.019997872412204742,
0.013900694437325,
-0.019291425123810768,
-0.021421633660793304,
-0.020171767100691795,
-0.021899843588471413,
0.0029888125136494637,
-0.010987961664795876,
0.01225956529378891,
-0.00014324222865980119,
0.017389453947544098,
0.0013307008193805814,
0.03662653639912605,
-0.05477678030729294,
-0.0010562734678387642,
-0.005287481006234884,
0.010015239007771015,
0.015878744423389435,
0.04738626256585121,
-0.026149392127990723,
0.012063933536410332,
-0.025214707478880882,
0.046951524913311005,
-0.029040388762950897,
-0.0017117743846029043,
0.013965905643999577,
-0.00562440138310194,
-0.013965905643999577,
0.020095687359571457,
-0.013944168575108051,
-0.02795354649424553,
-0.005347257014364004,
-0.0204326082020998,
-0.004124561324715614,
0.008999042212963104,
-0.036713484674692154,
0.010042409412562847,
-0.0041734687983989716,
0.000573987839743495,
0.00022025509679224342,
0.03099670261144638,
-0.027171021327376366,
-0.001748455222696066,
-0.018476294353604317,
-0.037365589290857315,
-0.017454665154218674,
-0.015965692698955536,
-0.02897517755627632,
-0.00843388494104147,
-0.013922431506216526,
-0.0037006931379437447,
0.03653959184885025,
0.0069503472186625,
0.0007451652782037854,
0.039952270686626434,
-0.0008993608062155545,
0.00028903174097649753,
0.02573639154434204,
-0.0015229358104988933,
-0.0069123078137636185,
0.017487268894910812,
0.02245413325726986,
0.010172830894589424,
0.02273671142756939,
-0.0016506395768374205,
-0.002755141584202647,
-0.003464305307716131,
-0.02301928959786892,
0.005928717087954283,
-0.028540441766381264,
-0.00750463642179966,
0.1287689059972763,
-0.03823506087064743,
-0.010547790676355362,
0.011194461025297642,
-0.007765477988868952,
-0.01296601165086031,
0.0006130461697466671,
0.013368142768740654,
0.014715825207531452,
-0.00902077928185463,
0.01707427017390728,
0.02254107967019081,
0.023823551833629608,
0.02517123520374298,
0.026649339124560356,
-0.019606608897447586,
0.012498670257627964,
0.03964795544743538,
-0.012281302362680435,
0.00027799353119917214,
-0.0014713108539581299,
0.023236658424139023,
-0.02560597099363804,
0.03062717616558075,
-0.04071306064724922,
-0.001255980459973216,
-0.008841450326144695,
-0.0047603631392121315,
-0.002381540136411786,
-0.03062717616558075,
-0.009748962707817554,
0.016530849039554596,
0.03308343514800072,
-0.01606350764632225,
0.004159883596003056,
-0.03399638086557388,
-0.028779545798897743,
-0.013085564598441124,
-0.003173575270920992,
0.00407565338537097,
-0.00497773103415966,
0.00995546206831932,
0.0043174754828214645,
0.0061786905862390995,
0.01642216555774212,
0.01106404047459364,
-0.02856217883527279,
-0.0008993608062155545,
0.008428450673818588,
-0.008846884593367577,
0.015433140099048615,
-0.02367139421403408,
0.04769057780504227,
-0.014520194381475449,
-0.004836441949009895,
-0.04212595149874687,
0.0022565533872693777,
0.00003313591150799766,
-0.01885668933391571,
-0.03988705947995186,
-0.03536580130457878,
0.018378479406237602,
0.005868940614163876,
0.0020011458545923233,
0.011091210879385471
] | 2024-07-15 | 1 | 39007933 | [
"haematological B cell malignancies",
"unprecedented efficacy",
"significant therapeutic efficacy",
"tumour stem cells",
"haematological malignancies",
"BM",
"the anti-tumour efficacy",
"haematologic malignancies",
"CAR-T cells",
"corresponding strategies",
"the anti-tumour activity",
"CAR-T therapy",
"immune attack",
"recent years",
"CAR-T",
"the BM microenvironment",
"non-Hodgkins lymphoma",
"niches",
"acute B-lymphocytic leukaemia",
"CD19",
"non-Hodgkins",
"the CAR-T therapy",
"the regulatory bone marrow",
"the efficacy",
"NHL",
"attention",
"a novel immunotherapy method",
"(BM) microenvironment",
"a protective environment",
"its underlying mechanism"
] | [
"CAR‐T cells",
"bone marrow microenvironment",
"haematologic malignancies"
] | 0 | 10.1111/sji.13273 | [
"Gao",
"Hong",
"He"
] | [
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.\nNational-Local Joint Engineering Research Center of Biodiagnostics & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China."
] | [
"39007933"
] | [] | 6.766575 | 6.376063 |
39007146 | 728 | Advances in CAR-NK cell therapy for hematological malignancies. | Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized the treatment of hematological malignancies, demonstrably improving patient outcomes and prognosis. However, its application has introduced new challenges, such as safety concerns, off-target toxicities, and significant costs. Natural killer (NK) cells are crucial components of the innate immune system, capable of eliminating tumor cells without prior exposure to specific antigens or pre-activation. This inherent advantage complements the limitations of T cells, making CAR-NK cell therapy a promising avenue for hematological tumor immunotherapy. In recent years, preclinical and clinical studies have yielded preliminary evidence supporting the safety and efficacy of CAR-NK cell therapy in hematological malignancies, paving the way for future advancements in immunotherapy. This review aims to succinctly discuss the characteristics, significant therapeutic progress, and potential challenges associated with CAR-NK cell therapy. | [
0.01158971432596445,
0.02374798059463501,
0.05484340339899063,
0.05956675857305527,
-0.023791715502738953,
-0.025912852957844734,
-0.006265006028115749,
0.030679943040013313,
0.020456939935684204,
0.018849685788154602,
0.004081001039594412,
-0.007112367078661919,
-0.05978543311357498,
0.014629281125962734,
0.03135783225297928,
-0.03210132196545601,
0.014454342424869537,
-0.012453475967049599,
0.04432519152760506,
0.025125626474618912,
0.01562424749135971,
0.008648551069200039,
0.013984193094074726,
0.009249904192984104,
-0.03975490853190422,
-0.009331907145678997,
0.007637184578925371,
0.006609417498111725,
-0.03409125283360481,
-0.05046992748975754,
0.012530012056231499,
-0.01642240770161152,
-0.006177536677569151,
0.0010926859686151147,
0.013634314760565758,
0.05528075248003006,
0.02746543660759926,
0.010507279075682163,
-0.047889575362205505,
-0.029171092435717583,
0.0636778250336647,
0.02239220403134823,
0.00981298927217722,
0.09997768700122833,
-0.07120020687580109,
0.008238537237048149,
-0.015132230706512928,
-0.04972643405199051,
0.023354368284344673,
-0.013415641151368618,
-0.027815314009785652,
-0.002911095740273595,
-0.02672194503247738,
0.02256714180111885,
-0.0665205866098404,
0.05615544691681862,
-0.02838386781513691,
-0.008839890360832214,
-0.006614884361624718,
0.01164438296109438,
0.00040352161158807576,
-0.028908684849739075,
-0.015482109040021896,
0.004337942693382502,
-0.05646159127354622,
-0.012048929929733276,
-0.04318808764219284,
-0.03603745251893997,
0.0065438151359558105,
0.05453725904226303,
0.017428306862711906,
-0.013196967542171478,
-0.013667115941643715,
-0.0019694315269589424,
0.027749713510274887,
0.009610716253519058,
-0.020282000303268433,
0.022982623428106308,
0.014137265272438526,
0.00849001295864582,
0.05396870896220207,
0.011316372081637383,
0.011381974443793297,
-0.04261953383684158,
-0.00563631858676672,
-0.03199198469519615,
-0.0008466778672300279,
-0.016542676836252213,
-0.05567436292767525,
-0.0033402431290596724,
-0.02313569374382496,
0.0016168198781087995,
-0.03765564039349556,
0.04592151194810867,
-0.007205303758382797,
0.0454404279589653,
-0.02328876592218876,
-0.05300654470920563,
0.029827114194631577,
0.04627138748764992,
0.030854880809783936,
0.014246601611375809,
-0.022457804530858994,
0.004767090082168579,
0.04902667924761772,
0.03793991357088089,
-0.04364730045199394,
-0.006418077740818262,
0.01585385389626026,
-0.006598483771085739,
0.05681146681308746,
-0.03194824978709221,
0.0008740120683796704,
0.050294987857341766,
-0.0354032963514328,
-0.048458125442266464,
-0.024250930175185204,
-0.00918430183082819,
0.0044281454756855965,
0.03689027950167656,
-0.03240746632218361,
0.018193665891885757,
0.04749596118927002,
-0.02130976691842079,
-0.027880916371941566,
-0.02407599240541458,
0.0624532550573349,
0.015022894367575645,
-0.017657913267612457,
-0.04052026569843292,
0.03391631692647934,
0.007970661856234074,
0.006565682590007782,
-0.029630307108163834,
-0.06621444225311279,
0.015941323712468147,
-0.04226965829730034,
-0.021790850907564163,
-0.027443569153547287,
-0.009288172237575054,
0.005168903153389692,
-0.020992690697312355,
-0.012311338447034359,
-0.005756589118391275,
-0.036496665328741074,
-0.023835450410842896,
0.02287328615784645,
0.03262614086270332,
-0.006981162820011377,
0.03717455640435219,
-0.02794651873409748,
0.04718982055783272,
0.0513446219265461,
0.00021440288401208818,
-0.00855561438947916,
-0.012672150507569313,
-0.015175965614616871,
0.061010006815195084,
-0.03909888491034508,
-0.05930434912443161,
0.004655019845813513,
0.011037562973797321,
-0.028602540493011475,
-0.033216558396816254,
-0.020074259489774704,
-0.015438374131917953,
-0.01711122877895832,
0.015613313764333725,
-0.03404752165079117,
0.004329742398113012,
-0.02387918531894684,
-0.03748070076107979,
-0.057729899883270264,
0.0008254938293248415,
-0.04246646165847778,
0.010337806306779385,
0.03581877797842026,
0.03166397660970688,
-0.023376235738396645,
-0.021922053769230843,
0.023857317864894867,
0.015165031887590885,
0.03842099756002426,
-0.02082868479192257,
-0.04320995509624481,
0.01928703486919403,
-0.01479328703135252,
0.009031230583786964,
-0.04439079388976097,
-0.021298833191394806,
0.020664678886532784,
0.012464409694075584,
0.022118860855698586,
0.010496345348656178,
0.010250337421894073,
-0.0009553314303047955,
0.027574773877859116,
0.021637778729200363,
-0.03350083529949188,
-0.024622676894068718,
0.04377850517630577,
-0.030395666137337685,
-0.036693472415208817,
0.006177536677569151,
-0.010731419548392296,
0.005455912556499243,
-0.008522813208401203,
0.014607413671910763,
-0.022042324766516685,
0.011983327567577362,
0.036081187427043915,
0.018281133845448494,
-0.002688321750611067,
0.04500307887792587,
-0.03730576112866402,
-0.018412338569760323,
-0.016542676836252213,
0.049988843500614166,
-0.0085064135491848,
0.0026678210124373436,
-0.001638687215745449,
-0.031161025166511536,
-0.017067493870854378,
-0.0034605138935148716,
-0.04349423199892044,
-0.01608346216380596,
0.01590852253139019,
-0.021091094240546227,
0.0136780496686697,
-0.030286328867077827,
-0.01818273216485977,
0.01667388156056404,
0.03761190548539162,
-0.00985125731676817,
-0.042072851210832596,
-0.028777480125427246,
0.019975857809185982,
0.01233320590108633,
0.04990137368440628,
0.011742786504328251,
0.010600215755403042,
0.022676479071378708,
0.0273560993373394,
-0.018324868753552437,
-0.004805358126759529,
-0.016739483922719955,
-0.012661216780543327,
-0.06144735589623451,
0.017996858805418015,
-0.008282272145152092,
-0.028755612671375275,
0.02838386781513691,
0.003856860101222992,
0.007959728129208088,
0.019997725263237953,
0.01247534342110157,
0.036234259605407715,
-0.04065147042274475,
0.010693151503801346,
-0.018685681745409966,
0.012125465087592602,
-0.03199198469519615,
-0.042072851210832596,
-0.04373477026820183,
-0.0674390196800232,
0.00582219148054719,
0.007560648489743471,
0.020664678886532784,
0.022271933034062386,
-0.009069498628377914,
0.06538348644971848,
-0.0004995330818928778,
0.021451905369758606,
-0.048020780086517334,
-0.06831371039152145,
0.019943056628108025,
0.0022605410777032375,
0.026700077578425407,
0.010829823091626167,
0.016969092190265656,
-0.0005866609863005579,
0.022632744163274765,
0.02021639794111252,
-0.03992984816431999,
-0.024119727313518524,
-0.029674042016267776,
-0.0016222867416217923,
0.010884491726756096,
0.018204599618911743,
-0.05554316192865372,
0.005442245863378048,
-0.012005195021629333,
-0.014355938881635666,
-0.006215804256498814,
-0.0038787275552749634,
-0.014990093186497688,
-0.019888387992978096,
0.003531582886353135,
-0.03151090443134308,
0.0006785723380744457,
-0.04815198481082916,
0.007445844821631908,
-0.0024013123475015163,
-0.05510581284761429,
0.01839047111570835,
0.023835450410842896,
-0.019090227782726288,
-0.019680647179484367,
0.021659646183252335,
0.045352958142757416,
0.03673720732331276,
-0.01306576281785965,
0.027421701699495316,
0.03334776312112808,
-0.00486822659149766,
0.004094668198376894,
0.008227603510022163,
-0.06498987227678299,
0.02052254229784012,
-0.02376984804868698,
-0.02313569374382496,
-0.01698002591729164,
-0.009944193996489048,
0.010337806306779385,
0.018740350380539894,
-0.02146283909678459,
0.02910549007356167,
-0.013273503631353378,
0.05479966849088669,
-0.0306143406778574,
-0.019407305866479874,
-0.06254072487354279,
0.04963896423578262,
-0.038486599922180176,
-0.0007810756796970963,
-0.003968930337578058,
-0.030220726504921913,
-0.060441453009843826,
0.006702353712171316,
-0.010512745939195156,
0.014399673789739609,
0.0437566377222538,
-0.023113826289772987,
0.06442131847143173,
-0.013688983395695686,
-0.020970823243260384,
-0.018335802480578423,
0.018795019015669823,
0.0056472523137927055,
0.0231794286519289,
-0.009588848799467087,
0.025934720411896706,
0.02897428721189499,
0.019123028963804245,
-0.011075831018388271,
0.05602424219250679,
-0.05449352413415909,
0.008424410596489906,
0.026197127997875214,
-0.020719347521662712,
0.01539463922381401,
-0.012070797383785248,
-0.0463588573038578,
0.03660600259900093,
0.06114121153950691,
0.04810824990272522,
-0.021812718361616135,
0.03957996889948845,
-0.05786110460758209,
-0.0366278700530529,
-0.020128928124904633,
-0.010982894338667393,
0.014388740062713623,
0.010961026884615421,
-0.044434528797864914,
0.033850714564323425,
0.03124849498271942,
0.0010605682618916035,
0.019866520538926125,
0.0035069820005446672,
0.01134917326271534,
-0.02031480148434639,
0.012639349326491356,
-0.03135783225297928,
-0.014782353304326534,
0.03721829131245613,
0.008380675688385963,
-0.029367899522185326,
-0.06227831542491913,
0.043122485280036926,
-0.0029356966260820627,
-0.023419970646500587,
-0.0005914444336667657,
0.01134917326271534,
-0.028755612671375275,
0.07950981706380844,
-0.054318588227033615,
0.08974374830722809,
0.048633065074682236,
0.012453475967049599,
-0.004171203821897507,
-0.022938888520002365,
-0.02479761652648449,
-0.01849980838596821,
0.04216032102704048,
-0.04126375541090965,
0.03275734558701515,
0.022501539438962936,
0.019177697598934174,
-0.025890985503792763,
0.01338283997029066,
0.017176831141114235,
0.03004578873515129,
0.003424979280680418,
0.026109658181667328,
-0.022501539438962936,
-0.04828318953514099,
0.03986424580216408,
-0.03137969970703125,
0.043975312262773514,
0.046096447855234146,
-0.030964218080043793,
0.023398103192448616,
-0.017209632322192192,
-0.0030067656189203262,
0.012617481872439384,
0.0265907421708107,
0.015591446310281754,
0.007008497137576342,
-0.045178018510341644,
-0.021528441458940506,
0.06293433904647827,
0.013054829090833664,
-0.01667388156056404,
-0.005024031735956669,
0.024250930175185204,
-0.03277921304106712,
0.04141682758927345,
-0.04244459792971611,
0.035031553357839584,
-0.025628576055169106,
-0.03925195708870888,
-0.003288308158516884,
0.005409444682300091,
0.05344389006495476,
0.01186305657029152,
-0.01026127114892006,
0.027006221935153008,
-0.04911414906382561,
-0.015077563002705574,
-0.011753720231354237,
-0.012890824116766453,
0.025497371330857277,
-0.002886494854465127,
-0.03483474627137184,
-0.02075214870274067,
0.023113826289772987,
-0.0513446219265461,
0.006029931828379631,
0.025016289204359055,
0.04423772171139717,
-0.039820510894060135,
0.018149930983781815,
0.004116535186767578,
0.00819480326026678,
0.04705861583352089,
0.014279402792453766,
-0.022326601669192314,
0.0071178339421749115,
-0.03135783225297928,
0.020948955789208412,
-0.003351176856085658,
-0.022370336577296257,
-0.0026787547394633293,
-0.030133258551359177,
0.04841439425945282,
0.021626845002174377,
0.018893420696258545,
0.01880595274269581,
0.021834583953022957,
-0.002745723584666848,
-0.006407144013792276,
-0.022250065580010414,
-0.013207901269197464,
0.032035719603300095,
0.005625384859740734,
-0.004042732995003462,
0.016203733161091805,
-0.01631307043135166,
0.04119815677404404,
0.0024368467275053263,
0.005384843796491623,
0.0366278700530529,
-0.007757455110549927,
-0.02036947011947632,
0.0028946951497346163,
0.016433341428637505,
0.0112070357427001,
-0.010490878485143185,
0.00047459060442633927,
-0.03350083529949188,
0.012202001176774502,
-0.0027976587880402803,
0.010135533288121223,
0.046096447855234146,
0.03343523293733597,
0.01757044531404972,
0.05633038654923439,
-0.0004137719515711069,
0.03286668285727501,
-0.03748070076107979,
0.02026013284921646,
0.04373477026820183,
-0.007325574290007353,
-0.023704245686531067,
-0.03194824978709221,
-0.05125715211033821,
-0.012344139628112316,
-0.02479761652648449,
-0.00878522265702486,
-0.007035831455141306,
-0.011261703446507454,
0.0013017927994951606,
-0.007243571802973747,
0.02761850878596306,
-0.03776497393846512,
-0.04463133588433266,
-0.022982623428106308,
-0.02046787366271019,
-0.02285141870379448,
0.013995126821100712,
0.00020346918608993292,
-0.00582219148054719,
0.02582538314163685,
-0.020959889516234398,
-0.03500968590378761,
-0.03691214695572853,
0.0265907421708107,
-0.015689849853515625,
-0.02586911804974079,
0.02254527434706688,
-0.01928703486919403,
0.02973964437842369,
-0.0264376699924469,
0.017636047676205635,
0.013962325640022755,
0.004348876420408487,
-0.02300449088215828,
0.016247468069195747,
-0.0034386464394629,
0.022982623428106308,
-0.03164210915565491,
0.006598483771085739,
-0.014202866703271866,
0.027727846056222916,
-0.030964218080043793,
-0.009654451161623001,
-0.002045967383310199,
0.0051825703121721745,
-0.00578392343595624,
-0.029061755165457726,
-0.017176831141114235,
0.010102732107043266,
-0.0307674128562212,
-0.03947063162922859,
0.010179268196225166,
-0.009288172237575054,
-0.026262730360031128,
-0.0426851361989975,
0.035775043070316315,
-0.012048929929733276,
0.0038541266694664955,
0.006893693469464779,
-0.022960755974054337,
0.055630628019571304,
-0.0010106832487508655,
-0.006128334905952215,
0.03210132196545601,
-0.010862624272704124,
0.0352502278983593,
-0.012366007082164288,
0.0005473680212162435,
-0.017384571954607964,
0.038792744278907776,
-0.009364708326756954,
0.0064016771502792835,
-0.032669875770807266,
-0.020424138754606247,
-0.01570078358054161,
-0.00804173108190298,
0.01493542455136776,
0.0020610010251402855,
0.05239425599575043,
0.036496665328741074,
-0.07618597149848938,
0.011819321662187576,
0.013481243513524532,
-0.011135966517031193,
0.015536777675151825,
0.0006813057698309422,
-0.028558805584907532,
-0.006368875969201326,
-0.014388740062713623,
-0.04417211934924126,
-0.01277055311948061,
0.005816724617034197,
0.017767250537872314,
-0.024382134899497032,
0.012442542240023613,
0.010250337421894073,
0.044871874153614044,
0.02582538314163685,
-0.031314097344875336,
0.006970229092985392,
0.041591767221689224,
0.022326601669192314,
-0.002622719621285796,
0.0005661603063344955,
-0.007150635123252869,
-0.03231999650597572,
-0.03393818438053131,
-0.007484112866222858,
-0.018357669934630394,
-0.014016994275152683,
-0.0052208383567631245,
-0.0437566377222538,
-0.018838752061128616,
0.007456778548657894,
-0.009249904192984104,
-0.029914584010839462,
0.009916859678924084,
-0.04030159115791321,
-0.01913396269083023,
0.015285302884876728,
-0.0061556692235171795,
-0.020063325762748718,
0.03140156716108322,
-0.04530922323465347,
0.003080568043515086,
0.012661216780543327,
-0.029674042016267776,
0.0010134166805073619,
-0.027115559205412865,
-0.016017859801650047,
0.012945492751896381,
-0.015558645129203796,
-0.04718982055783272,
-0.011081297881901264,
0.010381541214883327,
-0.004734288901090622,
0.008457211777567863,
-0.03485661372542381,
0.028274530544877052,
-0.06796383857727051,
-0.0050595663487911224,
-0.0041192686185240746,
-0.005947928875684738,
0.001069451798684895,
0.053137749433517456,
0.0914931446313858,
-0.018434206023812294,
-0.0030012987554073334,
-0.00765358516946435,
0.004862759727984667,
-0.027662243694067,
-0.005464112851768732,
0.027268629521131516,
0.013688983395695686,
0.024775749072432518,
0.006899160332977772,
0.054449789226055145,
0.030264461413025856,
-0.008014396764338017,
-0.012606548145413399,
-0.0008138767443597317,
0.010026196017861366,
0.0039962646551430225,
-0.009195235557854176,
-0.014902623370289803,
0.023419970646500587,
-0.017898455262184143,
0.017198698595166206,
-0.009003896266222,
-0.05886700376868248,
0.003985330928117037,
-0.006937428377568722,
0.03837726265192032,
0.017056560143828392,
0.0109774274751544,
-0.008408010005950928,
-0.0012273070169612765,
-0.028362000361084938,
-0.047146085649728775,
-0.0068007567897439,
0.030986085534095764,
0.039077017456293106,
0.00040078817983157933,
-0.00833694078028202,
-0.0015525843482464552,
-0.01397325936704874,
0.007555181626230478,
0.032057587057352066,
0.02300449088215828,
-0.03380697965621948,
0.022523406893014908,
-0.01849980838596821,
0.013896724209189415,
-0.0084298774600029,
0.005584383849054575,
0.010971960611641407,
0.005663652904331684,
-0.002468281192705035,
0.00841347686946392,
-0.00232477649115026,
-0.01600692607462406,
-0.00296576414257288,
-0.0031297695823013783,
0.036824677139520645,
-0.004045466426759958,
0.01790938898921013,
0.006521947681903839,
0.01959317736327648,
0.004146602936089039,
-0.011633449234068394,
0.02059907838702202,
0.0273560993373394,
-0.01321883499622345,
0.05208811163902283,
-0.015274369157850742,
-0.006899160332977772,
0.0003182729706168175,
-0.06437758356332779,
-0.02945536933839321,
-0.011742786504328251,
-0.01101569551974535,
0.02910549007356167,
-0.016488008201122284,
-0.020533476024866104,
-0.009266304783523083,
0.004217672161757946,
0.0372401587665081,
-0.03424432501196861,
-0.017362704500555992,
0.00776292197406292,
-0.008129200898110867,
0.010529146529734135,
0.009233503602445126,
-0.01772351562976837,
0.015361838974058628,
-0.03627799451351166,
-0.02157217636704445,
0.005964329466223717,
-0.025781648233532906,
-0.013131365180015564,
0.013448442332446575,
-0.038617804646492004,
-0.013153232634067535,
-0.005991663783788681,
-0.021703381091356277,
-0.029018020257353783,
-0.038902077823877335,
0.0007742421585135162,
0.012945492751896381,
0.010277671739459038,
0.024010390043258667,
-0.002312476048246026,
0.033413365483284,
0.02466641180217266,
-0.009402976371347904,
0.016400540247559547,
-0.007495046593248844,
-0.015744518488645554,
-0.011819321662187576,
-0.031467169523239136,
-0.02182365022599697,
0.00845174491405487,
-0.016203733161091805,
0.010922758840024471,
0.0024696479085832834,
0.03415685519576073,
-0.010709552094340324,
-0.011327305808663368,
0.0038431931752711535,
-0.006172069814056158,
0.022075125947594643,
-0.015175965614616871,
-0.006352475378662348,
0.0017534910002723336,
-0.029039887711405754,
-0.010900892317295074,
-0.027443569153547287,
0.026065923273563385,
-0.026350200176239014,
0.038923945277929306,
-0.026962487027049065,
0.02048974111676216,
0.022982623428106308,
-0.06555842608213425,
-0.011830255389213562,
-0.007221704348921776,
-0.019374504685401917,
-0.005335642024874687,
0.02361677587032318,
-0.06516481190919876,
-0.00833694078028202,
0.018587278202176094,
-0.026700077578425407,
0.020653745159506798,
0.009140566922724247,
0.0016591879539191723,
0.023223163560032845,
0.013546845875680447,
-0.025322433561086655,
-0.0019502975046634674,
-0.04301314800977707,
-0.0048928274773061275,
0.0350971557199955,
0.003091501770541072,
-0.014082596637308598,
-0.028646275401115417,
0.03691214695572853,
-0.0062978072091937065,
0.005111501552164555,
0.0033730443101376295,
-0.03151090443134308,
-0.038902077823877335,
-0.004299674648791552,
0.0055051143281161785,
0.010042596608400345,
-0.025628576055169106,
0.019910255447030067,
-0.010709552094340324,
-0.03971117362380028,
0.02077401615679264,
-0.032801080495119095,
-0.011906791478395462,
-0.007188903167843819,
-0.019276101142168045,
0.024906951934099197,
0.011004761792719364,
-0.00028837614809162915,
-0.020741214975714684,
-0.016477074474096298,
-0.02466641180217266,
0.0021361701656132936,
0.02331063337624073,
-0.0006228788406588137,
0.022676479071378708,
-0.01970251463353634,
-0.04491560906171799,
-0.01813899725675583,
-0.014334071427583694,
-0.022304734215140343,
-0.015974124893546104,
0.05996037274599075,
0.0016591879539191723,
0.036518532782793045,
-0.025934720411896706,
0.04867679998278618,
0.03603745251893997,
0.0012095398269593716,
-0.03269174322485924,
-0.016181865707039833,
-0.032363731414079666,
0.004824492149055004,
-0.03914261981844902,
0.002196305664256215,
-0.01351404469460249,
0.013098563998937607,
-0.033063486218452454,
0.009293639101088047,
0.0013154599582776427,
0.0030587005894631147,
-0.013667115941643715,
-0.009238970465958118,
0.003389444900676608,
0.02387918531894684,
-0.02497255429625511,
-0.037415098398923874,
-0.03500968590378761,
-0.003263707272708416,
-0.017887521535158157,
0.00929910596460104,
-0.002905628876760602,
0.022676479071378708,
-0.006789823528379202,
-0.02390105277299881,
-0.006177536677569151,
-0.021025491878390312,
-0.0009402976138517261,
-0.01150224544107914,
-0.004857293330132961,
-0.007516914047300816,
-0.027902783825993538,
0.008249470964074135,
0.006959295365959406,
-0.039820510894060135,
0.04150429740548134,
-0.03004578873515129,
0.011535045690834522,
-0.01934170350432396,
-0.024578941985964775,
-0.018040593713521957,
0.018554477021098137,
0.017023760825395584,
0.020588144659996033,
-0.007910527288913727,
0.04202911630272865,
-0.007538781501352787,
0.015460241585969925,
-0.023704245686531067,
-0.007708253338932991,
0.011447576805949211,
0.01575545221567154,
0.001588118844665587,
-0.01972438208758831,
-0.003381244605407119,
0.04854559525847435,
0.021604977548122406,
-0.014093530364334583,
-0.03089861571788788,
0.005179836880415678,
0.011556913144886494,
0.0009628483094274998,
0.018270200118422508,
0.011545979417860508,
-0.0038841944187879562,
0.023113826289772987,
-0.025278698652982712,
0.01583198830485344,
-0.0037611904554069042,
-0.01329537108540535,
0.019713448360562325,
0.028646275401115417,
0.028580673038959503,
0.017176831141114235,
0.020325735211372375,
-0.008768822066485882,
0.0006662718951702118,
-0.0032855747267603874,
0.0010086331749334931,
0.045659102499485016,
-0.005018564872443676,
-0.038464732468128204,
0.03304161876440048,
0.0273560993373394,
0.0026869550347328186,
-0.031751442700624466,
0.03391631692647934,
0.05138835683465004,
0.04806451499462128,
-0.011059430427849293,
0.014366872608661652,
0.03063620813190937,
-0.004813558422029018,
-0.04552789777517319,
0.03732762858271599,
-0.03430992737412453,
0.036955881863832474,
-0.023048223927617073,
-0.006888226605951786,
-0.012300404720008373,
-0.002424546517431736,
-0.02882121503353119,
0.007238104939460754,
0.030286328867077827,
0.0355563685297966,
-0.005756589118391275,
-0.07155008614063263,
0.0361686572432518,
-0.008599349297583103,
-0.014596479944884777,
0.006718754302710295,
0.024404002353549004,
0.02571604587137699,
0.013907657004892826,
0.020708413794636726,
-0.042225923389196396,
0.0068335579708218575,
0.02497255429625511,
0.015810120850801468,
0.04259766638278961,
-0.01867474801838398,
-0.016586411744356155,
-0.031445302069187164,
0.021845517680048943,
0.009064031764864922,
-0.025366168469190598,
-0.04552789777517319,
-0.005838592071086168,
0.05007631331682205,
0.04364730045199394,
-0.035206492990255356,
-0.03374137729406357,
-0.00017698915326036513,
-0.018412338569760323,
-0.03177331015467644,
-0.028165193274617195,
0.0179312564432621,
0.039361294358968735,
-0.013852989301085472,
-0.02387918531894684,
0.011819321662187576,
0.0008008930017240345,
-0.033413365483284,
0.009665384888648987,
0.05173823609948158,
0.0015894855605438352,
0.05602424219250679,
-0.03719642385840416,
0.02930229716002941,
0.017712581902742386,
0.039208222180604935,
0.008998429402709007,
0.016105329617857933,
-0.003424979280680418,
0.0021662379149347544,
-0.04509054869413376,
-0.028733745217323303,
-0.0010988361900672317,
-0.024535207077860832,
-0.0008316439925692976,
-0.009780188091099262,
0.049988843500614166,
0.04854559525847435,
0.015766385942697525,
0.00026052939938381314,
-0.03912075236439705,
0.02359491027891636,
0.01636773906648159,
0.00486822659149766,
0.01726430095732212,
0.0054395124316215515,
-0.018838752061128616,
-0.00735837547108531,
0.01703469455242157,
0.0025557507760822773,
0.045659102499485016,
0.009446710348129272,
-0.0057237884029746056,
-0.045790307223796844,
-0.021703381091356277,
0.022742081433534622,
0.04226965829730034,
-0.008386142551898956,
-0.025453636422753334,
-0.012683084234595299,
-0.03780870884656906,
-0.001675588428042829,
0.04946402832865715,
0.024382134899497032,
0.014388740062713623,
0.02359491027891636,
0.021123895421624184,
0.01672855019569397,
0.019713448360562325,
0.014334071427583694,
0.001540284021757543,
0.003908795304596424,
-0.007686386350542307,
-0.02571604587137699,
0.009446710348129272,
0.003012232482433319,
0.01072048582136631,
-0.030745545402169228,
0.02554110623896122,
0.019068360328674316,
0.02838386781513691,
0.020019592717289925,
-0.011316372081637383,
0.016816020011901855,
-0.008112800307571888,
-0.012901757843792439,
0.01731896959245205,
0.02551923878490925,
0.005805790890008211,
0.006817157380282879,
0.02764037624001503,
-0.006429011467844248,
-0.02551923878490925,
-0.002870094496756792,
0.02387918531894684,
0.017231499776244164,
-0.00578392343595624,
-0.013054829090833664,
0.009167901240289211,
-0.022457804530858994,
-0.028777480125427246,
-0.00039361295057460666,
-0.0070139640010893345,
-0.004458213225007057,
-0.009452177211642265,
-0.03288854658603668,
0.0032063054386526346,
0.006073666270822287,
-0.002219539601355791,
-0.007948794402182102,
-0.010868091136217117,
0.021222298964858055,
-0.00959431566298008,
-0.009780188091099262,
0.015219700522720814,
0.00505409948527813,
-0.046971146017313004,
-0.051169682294130325,
0.05493087321519852,
-0.002022733213379979,
-0.046402592211961746,
-0.011764653958380222,
0.017745383083820343,
-0.03868340700864792,
0.012278537265956402,
0.012858022935688496,
-0.02746543660759926,
-0.0011651216773316264,
0.02674381248652935,
0.003783057676628232,
-0.01657547801733017,
0.021758049726486206,
-0.0014254802372306585,
-0.006412610877305269,
-0.012234802357852459,
-0.00278262491337955,
0.005707387812435627,
-0.007030364591628313,
-0.008987495675683022,
-0.007527847774326801,
0.03214505687355995,
-0.011392908170819283,
0.032057587057352066,
0.019199565052986145,
0.00809639971703291,
0.007074099499732256,
-0.0025051822885870934,
0.0004879160551354289,
-0.0024313798639923334,
0.027552906423807144,
-0.027290496975183487,
0.004242273047566414,
0.025912852957844734,
0.011294504627585411,
0.0015156831359490752,
-0.02212979458272457,
-0.012661216780543327,
-0.010572881437838078,
-0.0222609993070364,
-0.009506845846772194,
0.04570283740758896,
-0.0025256830267608166,
-0.048195719718933105,
0.047277286648750305,
-0.013940458185970783,
-0.021145762875676155,
0.027574773877859116,
-0.02039133757352829,
0.009856724180281162,
-0.00527004012838006,
-0.007642651442438364,
0.0219548549503088,
0.035621970891952515,
-0.0017165897879749537,
0.005641785450279713,
0.02231566794216633,
-0.021965788677334785,
-0.012005195021629333,
-0.024732014164328575,
0.004179404117166996,
0.02702808938920498,
0.015493042767047882,
-0.03253867104649544,
-0.0004130885936319828,
0.0007393909618258476,
0.005997130647301674,
0.022250065580010414,
0.04334115982055664,
-0.00011360790085745975,
0.04592151194810867,
-0.0038732606917619705,
-0.001898362417705357,
-0.007680919487029314,
0.003332042833790183,
0.006680486258119345,
-0.01613813079893589,
-0.025300566107034683,
-0.031445302069187164,
0.005690987221896648,
-0.0046850875951349735,
0.02067561261355877,
-0.00027983420295640826,
0.020325735211372375,
-0.010479944758117199,
-0.039842378348112106,
-0.002938430057838559,
-0.00805813167244196,
0.007708253338932991,
-0.012027062475681305,
0.01010819897055626,
-0.017100295051932335,
-0.028558805584907532,
0.009238970465958118,
0.0011924558784812689,
0.01501196064054966,
0.02615339308977127,
0.020500674843788147,
0.024097859859466553,
0.02126603201031685,
0.00519350403919816,
-0.006226737983524799,
0.010305006057024002,
-0.05497460812330246,
-0.00977472122758627,
-0.01775631681084633,
0.012289470992982388,
0.006352475378662348,
-0.03133596479892731,
-0.020861485973000526,
-0.006631284952163696,
-0.0005302841309458017,
0.020653745159506798,
0.000939614255912602,
-0.003277374431490898,
-0.000692581117618829,
0.008500946685671806,
0.01127263717353344,
-0.0006221954827196896,
-0.018456073477864265,
0.0009765154682099819,
-0.0024573474656790495,
0.001119336811825633,
0.005849525798112154,
0.00043188087875023484,
-0.025453636422753334,
0.0068718260154128075,
-0.00017630579532124102,
0.005179836880415678,
-0.00791599415242672,
0.0072982399724423885,
-0.011655316688120365,
0.0042012715712189674,
0.05353135988116264,
0.02481948211789131,
0.007609850261360407,
-0.025038156658411026,
-0.017286168411374092,
0.008238537237048149,
0.009364708326756954,
0.011043029837310314,
0.02899615280330181,
0.02884308248758316,
-0.032363731414079666,
-0.029783379286527634,
-0.013087630271911621,
-0.014312203973531723,
-0.013667115941643715,
-0.004127468913793564,
0.0019147630082443357,
0.024469604715704918,
-0.03210132196545601,
-0.007795723155140877,
-0.009638050571084023,
0.033216558396816254,
-0.001057151472195983,
-0.016488008201122284,
-0.00988952536135912,
-0.02313569374382496,
-0.011239835992455482,
-0.0036764543037861586,
0.013535912148654461,
0.001254641218110919,
0.025213096290826797,
0.01544930785894394,
0.014016994275152683,
-0.03107355535030365,
0.051913175731897354,
0.0275091715157032,
0.011436643078923225,
-0.02586911804974079,
-0.016925357282161713,
0.024097859859466553,
-0.008949227631092072,
-0.009561514481902122,
0.008462678641080856,
0.019461972638964653,
-0.01708936132490635,
-0.03557823598384857,
0.035315826535224915,
-0.007823057472705841,
-0.002647320507094264,
-0.00457301689311862,
-0.0221844632178545,
0.007385709788650274,
-0.00798159558326006,
0.009840323589742184,
0.007549714762717485,
-0.022589009255170822,
0.008183869533240795,
-0.012125465087592602,
-0.020795883610844612,
0.01913396269083023,
0.013634314760565758,
-0.017614180222153664,
-0.018226467072963715,
-0.015941323712468147,
-0.043253690004348755,
-0.0747864618897438,
0.01949477382004261,
0.0065820831805467606,
-0.02300449088215828,
-0.006817157380282879,
-0.00970911979675293,
-0.009922326542437077,
0.029630307108163834,
-0.05628665164113045,
0.022632744163274765,
0.029848981648683548,
0.03181704506278038,
0.01552584394812584,
0.017865654081106186,
0.02925856225192547,
0.02676567994058132,
-0.011414775624871254,
-0.006532881408929825,
-0.02239220403134823,
0.008085465990006924,
0.036649737507104874,
-0.01718776486814022,
0.024250930175185204,
0.03192638233304024,
-0.02971777692437172,
0.015077563002705574,
-0.022938888520002365,
-0.03002392128109932,
0.016761351376771927,
-0.02157217636704445,
-0.011338239535689354,
-0.011010228656232357,
-0.010343273170292377,
-0.030658075585961342,
0.008386142551898956,
0.03866153955459595,
-0.000779025605879724,
-0.0009068131330423057,
0.011753720231354237,
0.03859593719244003,
-0.021025491878390312,
-0.02146283909678459,
0.016816020011901855,
0.028886817395687103,
0.017122162505984306,
0.00721077062189579,
-0.0013250269694253802,
-0.008162002079188824,
-0.014979159459471703,
0.0034769142512232065,
0.008954694494605064,
-0.02126603201031685,
0.009353774599730968,
-0.030002053827047348,
-0.003233639756217599,
0.0222609993070364,
0.0222609993070364,
0.012114531360566616,
-0.009692719206213951,
-0.0020596343092620373,
-0.006128334905952215,
-0.04364730045199394,
-0.011983327567577362,
-0.016477074474096298,
-0.012606548145413399,
-0.024447737261652946,
-0.006090066861361265,
-0.023245031014084816,
0.014957292005419731,
-0.021965788677334785,
0.017482975497841835,
-0.01989932172000408,
-0.01186305657029152,
0.010611149482429028,
0.002924762899056077,
0.003971663769334555,
0.01941823959350586,
-0.03168584033846855,
-0.018335802480578423,
-0.009523246437311172,
-0.009741920046508312,
-0.015252501703798771,
0.007265438791364431,
-0.05764243006706238,
0.01109223160892725,
0.01388579048216343,
-0.025300566107034683,
0.002114302944391966,
0.04441266134381294,
-0.0010352840181440115,
0.009140566922724247,
-0.025431768968701363,
0.01716589741408825,
0.007363842334598303,
0.021758049726486206,
0.0011794720776379108,
-0.005502380896359682,
0.0008876791689544916,
-0.03883647918701172,
-0.002182638505473733,
-0.016334937885403633,
-0.03231999650597572,
-0.007866792380809784,
-0.042794473469257355,
0.001051001250743866,
-0.014574612490832806,
0.0017985925078392029,
-0.004387144464999437,
0.02105829305946827,
-0.0454404279589653,
0.0055625163950026035,
-0.01695815846323967,
0.0025762515142560005,
0.02374798059463501,
0.057161346077919006,
-0.028471335768699646,
0.012344139628112316,
-0.0004202638228889555,
0.01995399035513401,
-0.02200952358543873,
-0.004217672161757946,
-0.002756657311692834,
-0.00567458663135767,
-0.007631717715412378,
0.03763377293944359,
0.020970823243260384,
-0.039973583072423935,
0.017176831141114235,
-0.001675588428042829,
0.004963896702975035,
0.01749390922486782,
-0.039077017456293106,
0.009085899218916893,
-0.014377806335687637,
0.012748685665428638,
0.014683949761092663,
0.03258240595459938,
-0.04270700365304947,
-0.0017876587808132172,
-0.006746088620275259,
0.004879160318523645,
0.01762511394917965,
-0.01854354329407215,
-0.02838386781513691,
0.0009669484570622444,
-0.004633152391761541,
0.005865926388651133,
0.04233526065945625,
0.011841189116239548,
-0.006724221166223288,
0.014006060548126698,
-0.016990959644317627,
-0.008861757814884186,
0.03297601640224457,
-0.009025763720273972,
0.010102732107043266,
0.014673016034066677,
0.0018122595502063632,
0.00987312477082014,
0.035643838346004486,
0.011819321662187576,
-0.004409011919051409,
0.005100567825138569,
-0.0025858182925730944,
0.02046787366271019,
-0.013940458185970783,
-0.0031489036045968533,
0.1360151469707489,
-0.005844058934599161,
0.0023466439452022314,
0.012530012056231499,
-0.006620351225137711,
-0.014596479944884777,
0.030658075585961342,
0.00493656238541007,
0.018171798437833786,
-0.016608279198408127,
0.018357669934630394,
0.014399673789739609,
0.036234259605407715,
0.012387874536216259,
0.03483474627137184,
-0.013120431452989578,
0.0005835858755744994,
0.03247306868433952,
0.00479715783149004,
-0.0021662379149347544,
0.004433612339198589,
0.009244437329471111,
-0.011436643078923225,
0.016247468069195747,
-0.03553450107574463,
-0.0009737820364534855,
-0.008867224678397179,
-0.013962325640022755,
-0.003783057676628232,
-0.006128334905952215,
0.009244437329471111,
0.016662947833538055,
0.012694017961621284,
-0.006789823528379202,
-0.02031480148434639,
-0.059697963297367096,
-0.011556913144886494,
-0.0088508240878582,
-0.00012787296145688742,
0.00369832175783813,
0.006368875969201326,
-0.01638960652053356,
0.004482814110815525,
0.014476209878921509,
0.0366278700530529,
-0.014476209878921509,
-0.016433341428637505,
0.011032096110284328,
0.004321542102843523,
-0.044762540608644485,
-0.008796156384050846,
-0.016094395890831947,
0.01652080938220024,
-0.025475503876805305,
-0.034594204276800156,
-0.03684654459357262,
-0.002850960474461317,
-0.006368875969201326,
0.0054203784093260765,
-0.020347602665424347,
-0.017351770773530006,
0.026087790727615356,
0.02567231096327305,
-0.004630418960005045,
0.006713287439197302
] | 2024-07-15 | 110 | 39007146 | [
"tumor cells",
"T cells",
"hematological malignancies",
"hematological tumor immunotherapy",
"significant therapeutic progress",
"CAR-NK cell therapy",
"safety concerns",
"potential challenges",
"new challenges",
"specific antigens",
"significant costs",
"preliminary evidence",
"crucial components",
"prior exposure",
"patient outcomes",
"recent years",
"future advancements",
"Natural killer (NK) cells",
"immunotherapy",
"efficacy",
"pre",
"preclinical and clinical studies",
"-",
"the innate immune system",
"CAR-T",
"activation",
"prognosis",
"a promising avenue",
"the safety",
"This inherent advantage"
] | [
"CAR-NK",
"NK cells",
"chimeric antigen receptor",
"hematological malignancies",
"immunotherapy"
] | 0 | 10.3389/fimmu.2024.1414264
10.1007/s00277-020-04020-7
10.1038/s41571-021-00476-2
10.1186/s13046-022-02327-z
10.1056/NEJMra1706169
10.1126/science.aar6711
10.1182/blood-2007-09-077438
10.1038/ni0102-6
10.1016/j.cell.2020.02.029
10.1016/S1471-4906(01)02060-9
10.1038/s41409-019-0601-6
10.1186/s12943-020-01238-x
10.1007/s12026-015-8664-y
10.1038/ni1582
10.1146/annurev-immunol-020711-075005
10.1038/s41577-022-00732-1
10.21147/j.issn.1000-9604.2023.03.07
10.1158/2326-6066.CIR-15-0098
10.1016/j.molimm.2004.07.034
10.1002/JLB.MR0718-269R
10.1002/eji.200324070
10.1016/j.blre.2005.10.001
10.1007/978-3-642-56055-2_2
10.3390/cancers14174318
10.1038/nm.4478
10.3390/cells10123390
10.3390/cancers15010117
10.3389/fimmu.2022.822298
10.1016/S1465-3249(22)00299-7
10.1016/j.ebiom.2020.102975
10.3390/cancers14153839
10.1097/BS9.0000000000000023
10.1038/leu.2017.226
10.3389/fimmu.2021.732135
10.1182/bloodadvances.2019000835
10.1038/s41419-024-06438-7
10.3389/fimmu.2015.00195
10.1002/cti2.1274
10.3389/fimmu.2017.00533
10.3389/fimmu.2016.00091
10.1016/j.ymthe.2017.06.012
10.1016/j.jtct.2022.06.025
10.21147/j.issn.1000-9604.2024.01.01
10.1186/s40364-022-00364-6
10.1186/s12967-016-1047-x
10.3389/fimmu.2024.1384039
10.1186/s13045-021-01083-5
10.3389/fimmu.2020.611163
10.3389/fimmu.2021.780145
10.1038/s41573-019-0051-2
10.1038/s41586-023-05707-3
10.3389/fimmu.2016.00595
10.1002/ijc.33156
10.1182/blood-2021-153438
10.1038/s41577-021-00547-6
10.1056/NEJMoa1910607
10.3389/fonc.2021.673276
10.1038/s41571-019-0297-y
10.1016/j.coi.2009.02.009
10.1038/s41423-021-00732-6
10.1186/s40164-024-00522-6
10.1038/s41591-023-02785-8
10.1038/s41408-022-00660-2
10.1182/blood-2022-166420
10.1016/j.canlet.2023.216103
10.1186/s13045-022-01376-3
10.1073/pnas.2122379119
10.3324/haematol.2020.271908
10.1038/leu.2017.8
10.1002/ijc.32269
10.1093/stcltm/szac057.002
10.1182/blood-2022-168981
10.1186/s12967-024-04990-6
10.3390/cancers12061473
10.1038/leu.2013.279
10.1182/blood-2023-181613
10.1182/blood-2022-159289
10.1182/blood-2022-170501
10.1038/s41417-021-00365-x
10.1182/blood.2020006619
10.14336/AD.2022.0415
10.1016/S2666-6367(22)00362-1
10.1016/j.ccell.2023.01.007
10.1182/blood-2023-184864
10.1182/bloodadvances.2023012202
10.1182/blood-2021-151185
10.1182/blood-2022-170712
10.1182/blood-2022-166994
10.1186/s13045-020-00856-8
10.1186/s12967-022-03326-6
10.1182/blood.2022017794
10.3389/fphar.2015.00021
10.1056/NEJMoa1106152
10.1182/blood-2019-03-900928
10.1126/sciadv.add6997
10.1182/blood.2020007748
10.1371/journal.pone.0064835
10.3390/cells13050451
10.1038/s43018-022-00476-w
10.1038/s41591-022-02003-x
10.1182/blood.2021012811
10.3389/fimmu.2023.1166038
10.1158/2159-8290.CD-20-0556
10.1038/leu.2015.327
10.1371/journal.pone.0191358
10.3389/fimmu.2019.02354
10.1172/JCI123955
10.3390/ijms232112828
10.3389/fimmu.2022.1081546
10.1186/s13045-019-0758-x
10.1080/14712598.2020.1738378
10.1111/j.1365-2567.2007.02573.x
10.1038/s41586-023-06945-1
10.1126/science.1068440
10.1182/blood.2022016200
10.1016/j.omto.2021.10.001
10.1016/j.omto.2022.10.011
10.1155/2021/7855808
10.3389/fimmu.2023.1167666
10.1038/s41389-017-0011-9
10.1002/cti2.1238
10.1016/j.bbrc.2020.01.005 | [
"Yang",
"Yang",
"Liu",
"Wang",
"Yang",
"He"
] | [
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.\nXi'an Key Laboratory of Hematological Diseases, Xi'an, Shaanxi, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.",
"Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.\nXi'an Key Laboratory of Hematological Diseases, Xi'an, Shaanxi, China."
] | [
"39007146",
"32388608",
"33633361",
"35361234",
"29972754",
"29567707",
"18650461",
"11753399",
"32200803",
"11698225",
"31431708",
"32762681",
"26013798",
"18425107",
"23516982",
"35637393",
"37440830",
"26041808",
"15607806",
"31107565",
"14515256",
"16364519",
"11987821",
"36077853",
"29400710",
"34943898",
"36612114",
"35371071",
"32853984",
"35954502",
"35402797",
"28725044",
"34925314",
"31821460",
"38221520",
"25972867",
"33959279",
"28572802",
"27014270",
"28668320",
"35788086",
"38455373",
"35303962",
"27729044",
"38726000",
"33933160",
"33488617",
"34975869",
"31900462",
"36813894",
"28066411",
"32535920",
"34002066",
"32023374",
"34178661",
"31848460",
"19327974",
"34267335",
"38745250",
"38238616",
"35418180",
"36805460",
"36335396",
"35696582",
"33375774",
"28074066",
"30755812",
"30860598",
"38475814",
"32516895",
"24067492",
"34471234",
"32614951",
"36186137",
"36787696",
"38564778",
"32245502",
"35287669",
"36480219",
"25729364",
"22047558",
"31023743",
"37494448",
"32902645",
"23724099",
"38474415",
"36539491",
"36175679",
"35090171",
"37205115",
"33277313",
"26621337",
"29342200",
"31681269",
"30860984",
"36361619",
"36741400",
"31221182",
"32125191",
"17346281",
"38383621",
"11896281",
"36416736",
"34761106",
"36420307",
"34790830",
"37205105",
"29362402",
"33456775",
"31952789"
] | [] | 11.420594 | 5.762283 |
39007104 | 729 | Treatment of AL amyloidosis in the era of novel immune and cellular therapies. | Light chain (AL) amyloidosis is a plasma cell disorder distinguished from multiple myeloma (MM) by the degree of organ involvement due to tissue deposition of misfolded proteins. Treatments for AL amyloidosis have largely been borrowed from those developed for patients with MM. High-dose chemotherapy followed by autologous stem cell transplant (ASCT) has historically been associated with the best outcomes. The recent incorporation of daratumumab into up front therapy represents a significant advance and has changed the treatment paradigm, calling into question the role of ASCT. The development of very active novel immune and cellular therapies, specifically B cell maturation antigen (BCMA)-directed therapies, has similarly been transformative for patients with MM and is now being studied in patients with AL amyloidosis. These include chimeric antigen receptor (CAR) T cells, bispecific antibodies, and antibody drug conjugates. Although limited, preliminary data in patients with relapsed and refractory AL amyloidosis are showing promising results, and it is expected that the treatment landscape for AL amyloidosis will continue to evolve. Particular attention to safety, potential for organ recovery, and quality of life will be important when evaluating new treatments and/or treatment paradigms. | [
-0.0004317756975069642,
-0.016838066279888153,
0.054357122629880905,
0.06891977787017822,
-0.007262364495545626,
0.010485867969691753,
0.01457529328763485,
-0.015839412808418274,
0.0016686372691765428,
0.01697712019085884,
-0.0134755102917552,
-0.05142436549067497,
-0.009114298969507217,
0.02309545688331127,
-0.01313419733196497,
-0.014284546487033367,
0.01865839771926403,
0.013197403401136398,
-0.008336865343153477,
0.0294792577624321,
0.014221340417861938,
-0.03155241161584854,
-0.003827120643109083,
-0.007831217721104622,
-0.03051583655178547,
-0.005306140054017305,
-0.008520162664353848,
-0.0024587116204202175,
-0.0020273311529308558,
-0.02748194895684719,
0.012786565348505974,
-0.04770785570144653,
0.005176567938178778,
-0.0012443672167137265,
-0.028063444420695305,
0.07422907650470734,
0.008008195087313652,
0.004373852163553238,
-0.005135484039783478,
-0.015548665076494217,
0.028619656339287758,
-0.017685025930404663,
0.012337802909314632,
0.06613871455192566,
-0.02834155037999153,
-0.001862995559349656,
0.0005384357646107674,
-0.035724006593227386,
-0.001965705305337906,
-0.007268684916198254,
0.007110670208930969,
0.009841167367994785,
-0.0005633230903185904,
0.029100021347403526,
-0.054862771183252335,
0.0157888475805521,
-0.02733025513589382,
-0.0096515491604805,
0.005903436336666346,
-0.006434366572648287,
-0.020997019484639168,
0.0014260844327509403,
0.020074211061000824,
-0.004500264301896095,
-0.04305589571595192,
-0.03428291156888008,
-0.07756634801626205,
0.000308326561935246,
0.0044844625517725945,
-0.0042822035029530525,
0.00967051088809967,
-0.07448189705610275,
0.013070992194116116,
0.01935366354882717,
-0.010378417558968067,
0.02575010620057583,
-0.021237201988697052,
-0.0006632675067521632,
-0.0029201151337474585,
0.04421888664364815,
-0.00012315285857766867,
0.006838884670287371,
0.0034794879611581564,
-0.028594374656677246,
0.06047545745968819,
0.0525873564183712,
0.0014276645379140973,
-0.00006251464219531044,
-0.02659706585109234,
-0.02427108772099018,
0.005818108096718788,
-0.003270908258855343,
-0.03949107974767685,
0.03880845755338669,
-0.009411366656422615,
0.02441013976931572,
0.019568564370274544,
-0.036027394235134125,
-0.0005708287935703993,
0.045533571392297745,
0.015295841731131077,
0.006484931334853172,
0.012445252388715744,
-0.007919706404209137,
0.03167882561683655,
-0.031982213258743286,
-0.03759490326046944,
-0.00795762985944748,
0.03003546968102455,
-0.019024992361664772,
0.048087090253829956,
-0.01935366354882717,
-0.01714145578444004,
0.03438404202461243,
-0.022109443321824074,
-0.028695503249764442,
-0.026066135615110397,
0.01815275102853775,
0.03167882561683655,
0.03104676492512226,
-0.02104758284986019,
0.05885738506913185,
0.02068098820745945,
-0.0353194884955883,
-0.012280917726457119,
-0.026698196306824684,
0.07726296037435532,
-0.026748761534690857,
-0.057947222143411636,
-0.03311992064118385,
0.0706389769911766,
-0.005084919277578592,
0.009360802359879017,
-0.020428165793418884,
-0.06735226511955261,
0.022273778915405273,
-0.03744320943951607,
-0.032235037535429,
-0.04866858571767807,
-0.004885820206254721,
0.039946164935827255,
-0.009303917177021503,
0.0018693162128329277,
0.012912976555526257,
-0.005745421629399061,
-0.028063444420695305,
0.003130275057628751,
0.008494880050420761,
0.012015452608466148,
0.019416870549321175,
-0.0397186242043972,
0.02257716841995716,
0.01228723768144846,
0.02409411035478115,
-0.020807400345802307,
-0.010233044624328613,
-0.02322186902165413,
0.03726623207330704,
-0.012875053100287914,
-0.037240948528051376,
-0.039592210203409195,
-0.003014924004673958,
-0.019960440695285797,
-0.02983321063220501,
0.004177913535386324,
0.015991106629371643,
-0.0372915156185627,
0.03306935727596283,
-0.0525873564183712,
-0.000703166238963604,
-0.017849361523985863,
0.0010421081678941846,
-0.06790848076343536,
-0.03506666421890259,
-0.03832809254527092,
-0.02965623512864113,
0.028973611071705818,
-0.008482239209115505,
-0.054508816450834274,
-0.03038942441344261,
0.002286475384607911,
-0.004591912496834993,
0.023992981761693954,
-0.019720258191227913,
-0.049604035913944244,
0.015055659227073193,
-0.037898290902376175,
0.04171593114733696,
-0.02763364464044571,
0.019884593784809113,
0.03539533540606499,
0.033853109925985336,
0.03592626377940178,
0.013336456380784512,
0.03901071473956108,
0.015649795532226562,
0.06244748458266258,
0.07670675218105316,
-0.027203842997550964,
-0.020415524020791054,
0.04530603066086769,
-0.03767075017094612,
-0.004294844809919596,
-0.04035068303346634,
-0.04495207592844963,
0.009613625705242157,
0.005874993745237589,
0.010473227128386497,
0.02270357869565487,
-0.04783426597714424,
0.041463106870651245,
-0.03445988893508911,
0.018759528174996376,
0.03981975093483925,
-0.011061042547225952,
-0.02121191844344139,
-0.021616436541080475,
0.02240019105374813,
-0.005707497708499432,
0.018544627353549004,
0.034839123487472534,
0.0024982155300676823,
-0.017583897337317467,
0.07529093325138092,
-0.0627003088593483,
0.011983849108219147,
-0.00958202313631773,
-0.0006411453941836953,
-0.0052650561556220055,
-0.012318841181695461,
-0.01245157327502966,
-0.02611670084297657,
-0.02459975890815258,
0.0012151345144957304,
-0.04684825614094734,
-0.019745539873838425,
-0.029201151803135872,
0.0052903383038938046,
0.05319413170218468,
-0.03071809560060501,
0.03870732709765434,
0.01712881401181221,
0.05592463165521622,
0.00449394341558218,
0.0023354601580649614,
-0.013374380767345428,
0.02049137093126774,
-0.050767023116350174,
0.06143619120121002,
0.03243729844689369,
-0.046924103051424026,
0.010410021059215069,
-0.01187007874250412,
-0.04121028259396553,
-0.004399134777486324,
0.03137543797492981,
-0.015498100779950619,
-0.024839941412210464,
-0.020769476890563965,
0.0013597181532531977,
-0.017356354743242264,
0.038732610642910004,
0.007578394375741482,
-0.0012546381913125515,
-0.04887084662914276,
0.06047545745968819,
0.02405618689954281,
0.004010417964309454,
0.01542225293815136,
-0.016382982954382896,
-0.005318781360983849,
0.026040853932499886,
-0.0028521688655018806,
-0.002171124564483762,
0.009424008429050446,
-0.02357582189142704,
-0.00855808611959219,
0.019214611500501633,
0.02492842823266983,
0.05124738812446594,
0.0016844387864694,
-0.018064262345433235,
0.02170492522418499,
-0.06391385942697525,
-0.008046118542551994,
0.030086034908890724,
-0.010966232977807522,
-0.03463686257600784,
-0.03119846060872078,
-0.019024992361664772,
-0.007180196698755026,
0.013323815539479256,
0.0006055920966900885,
0.0007636069785803556,
-0.004136829636991024,
0.004686721600592136,
-0.02156587317585945,
0.008968925103545189,
-0.018620474264025688,
0.05546954646706581,
0.010890386067330837,
0.028872480615973473,
-0.004269562195986509,
-0.03380254656076431,
0.04414303973317146,
0.038226962089538574,
-0.03673529997467995,
-0.0013644585851579905,
0.013020426966249943,
0.02715327963232994,
0.048896126449108124,
0.010561714880168438,
0.04437058046460152,
0.0100118238478899,
-0.026066135615110397,
-0.028973611071705818,
-0.014436240307986736,
-0.043308719992637634,
0.005615849047899246,
-0.021616436541080475,
0.016661090776324272,
-0.018228597939014435,
-0.02049137093126774,
-0.015637153759598732,
0.014044363051652908,
-0.026521218940615654,
0.006889449432492256,
0.005081758834421635,
-0.006807281635701656,
-0.047404468059539795,
0.015460177324712276,
-0.0076732030138373375,
0.07109405845403671,
-0.03172938898205757,
0.006118336692452431,
-0.015713000670075417,
0.00036580447340384126,
-0.010321532376110554,
0.020782118663191795,
0.01127594243735075,
-0.035850416868925095,
0.014714346267282963,
-0.011244339868426323,
0.07266156375408173,
-0.015333765186369419,
-0.033827826380729675,
0.010150876827538013,
0.010043426416814327,
-0.033145204186439514,
0.025674259290099144,
-0.0023354601580649614,
-0.0050691175274550915,
0.011882719583809376,
-0.0071549140848219395,
-0.010195121169090271,
0.001806110143661499,
-0.03751905634999275,
-0.040426529943943024,
0.01898706890642643,
0.023980339989066124,
0.009550419636070728,
0.0099296560510993,
-0.021907184273004532,
0.045204900205135345,
0.04899725690484047,
0.02796231582760811,
-0.01154140755534172,
0.01591525971889496,
-0.01782407984137535,
-0.02068098820745945,
0.011629896238446236,
0.010618600994348526,
0.01414549257606268,
0.04151367023587227,
-0.03324633464217186,
0.049098387360572815,
0.03473799303174019,
0.000861181179061532,
-0.006178382318466902,
0.028366833925247192,
0.03119846060872078,
-0.004079944454133511,
0.016420908272266388,
0.00022536874166689813,
-0.0012751801405102015,
0.05228396877646446,
-0.00855808611959219,
-0.006187863182276487,
-0.05890795215964317,
0.035698723047971725,
0.02342412807047367,
-0.005116522312164307,
-0.005795986391603947,
0.03491497039794922,
-0.05546954646706581,
0.05086815357208252,
-0.042145732790231705,
0.0888928547501564,
0.03898543491959572,
0.020630424842238426,
0.02372751571238041,
0.0011961726704612374,
-0.00577070377767086,
-0.08464541286230087,
0.01711617223918438,
0.012154505588114262,
-0.019416870549321175,
0.004089425317943096,
0.02049137093126774,
-0.012925618328154087,
-0.009961258620023727,
0.013968516141176224,
0.05155077949166298,
-0.003144496353343129,
0.005931878928095102,
-0.031982213258743286,
-0.05845286697149277,
0.06613871455192566,
0.007786973845213652,
0.03117317706346512,
0.02394241653382778,
-0.03870732709765434,
0.043637391179800034,
-0.03193164989352226,
-0.010504829697310925,
-0.013917951844632626,
0.06411612033843994,
0.0016465152148157358,
-0.04138725996017456,
-0.04548300430178642,
-0.029580388218164444,
0.08221830427646637,
0.030465271323919296,
-0.038909588009119034,
-0.0010073449229821563,
0.02459975890815258,
-0.0413619764149189,
-0.0008722422062419355,
-0.04598865285515785,
0.00482577458024025,
-0.012495817616581917,
0.024220522493124008,
-0.04356154426932335,
-0.05273905023932457,
-0.021806055679917336,
0.010523791424930096,
-0.019113481044769287,
0.0218945425003767,
-0.055014465004205704,
0.025345588102936745,
0.001802949933335185,
-0.037898290902376175,
-0.0026751921977847815,
0.0359768308699131,
-0.004642477259039879,
-0.001204073429107666,
0.03719038516283035,
-0.04922479763627052,
0.0025740626733750105,
0.023373562842607498,
0.032462578266859055,
-0.0569864884018898,
0.00832422450184822,
0.010435303673148155,
-0.029630951583385468,
0.017406919971108437,
0.045558854937553406,
-0.017027685418725014,
0.0014245042111724615,
-0.03853034973144531,
0.018178032711148262,
0.03147656470537186,
-0.016926554962992668,
-0.00890571903437376,
0.006279511842876673,
0.056379713118076324,
0.01263487059623003,
-0.030237728729844093,
0.04965459927916527,
0.005024873651564121,
0.013943233527243137,
0.014524728991091251,
0.000993123627267778,
-0.017899926751852036,
0.03683643043041229,
0.0034826481714844704,
-0.047202207148075104,
-0.0006387751782312989,
-0.015991106629371643,
0.023537898436188698,
0.00037943324423395097,
-0.029605669900774956,
0.01678750105202198,
-0.012995144352316856,
0.018102185800671577,
-0.04935121163725853,
-0.02020062319934368,
-0.03352443873882294,
-0.0024808337911963463,
0.006807281635701656,
-0.04022426903247833,
0.013020426966249943,
-0.011408675462007523,
-0.008210454136133194,
0.02524445950984955,
0.01884801685810089,
-0.0004756248090416193,
0.04593808948993683,
0.0015090422239154577,
0.039440516382455826,
-0.025320306420326233,
0.005211330950260162,
0.030793942511081696,
-0.00838743057101965,
-0.028063444420695305,
-0.030414706096053123,
-0.027052149176597595,
-0.013374380767345428,
0.004813133738934994,
-0.011238018982112408,
0.011294904164969921,
-0.008678177371621132,
-0.0008358987979590893,
0.006228947080671787,
0.04373852163553238,
-0.014853399246931076,
-0.03443460538983345,
0.007989232428371906,
-0.024334292858839035,
-0.0057485816068947315,
-0.006763037294149399,
-0.015207353048026562,
-0.008507521823048592,
0.008033476769924164,
-0.04596337303519249,
-0.027734773233532906,
-0.02151530794799328,
0.021123429760336876,
-0.0012822907883673906,
-0.05890795215964317,
0.016420908272266388,
-0.0032187632750719786,
0.013804180547595024,
0.007881782948970795,
0.020832683891057968,
0.0006138878525234759,
-0.013778898864984512,
0.014082287438213825,
0.029605669900774956,
0.007464623544365168,
0.06603758037090302,
-0.001845613936893642,
0.01247053500264883,
-0.005859191995114088,
0.009013169445097446,
-0.020314393565058708,
-0.033676132559776306,
-0.026394806802272797,
-0.0009686312987469137,
-0.011680460534989834,
0.006933693308383226,
-0.029605669900774956,
-0.01609223708510399,
-0.028038162738084793,
0.004373852163553238,
-0.008039797656238079,
0.004070463590323925,
0.00949985533952713,
-0.03539533540606499,
0.02035231702029705,
-0.02829098515212536,
0.023272432386875153,
-0.012742321006953716,
-0.028746068477630615,
-0.009424008429050446,
0.00537882698699832,
-0.013437585905194283,
0.051980577409267426,
0.03054111823439598,
-0.03370141610503197,
-0.024890504777431488,
-0.043359287083148956,
-0.04930064454674721,
0.029125304892659187,
-0.019568564370274544,
0.024169957265257835,
-0.039086561650037766,
-0.019581206142902374,
-0.019796105101704597,
0.004945866297930479,
0.03362556919455528,
0.018253879621624947,
0.0008659216109663248,
-0.0017113012727349997,
-0.031072048470377922,
0.032639555633068085,
0.0003124744398519397,
0.0018361330730840564,
-0.0032314045820385218,
-0.02140153758227825,
0.018051620572805405,
-0.00917118415236473,
-0.008861474692821503,
-0.02659706585109234,
-0.020048929378390312,
0.049250081181526184,
-0.028189856559038162,
0.0064628091640770435,
-0.005931878928095102,
0.01782407984137535,
0.061790142208337784,
0.03693756088614464,
-0.014309828169643879,
-0.00846959836781025,
0.01077661570161581,
0.011042080819606781,
0.03188108280301094,
0.028619656339287758,
0.0005716188461519778,
-0.034839123487472534,
-0.04249968379735947,
0.006121496669948101,
0.005710658151656389,
0.021591154858469963,
0.041286129504442215,
-0.050590045750141144,
-0.013172121718525887,
-0.014663781970739365,
0.015194712206721306,
0.0009883831953629851,
-0.058756258338689804,
-0.008931001648306847,
0.002866390161216259,
0.023639027029275894,
0.017520690336823463,
-0.012995144352316856,
0.046039219945669174,
-0.020301753655076027,
0.029276998713612556,
0.003188740462064743,
-0.02049137093126774,
0.030591683462262154,
0.001351817394606769,
-0.04748031497001648,
0.007521508727222681,
-0.017887284979224205,
-0.003130275057628751,
-0.011806872673332691,
-0.01680014282464981,
-0.013526074588298798,
0.004737286362797022,
-0.03003546968102455,
0.04437058046460152,
-0.006605022586882114,
0.021098148077726364,
-0.02813929133117199,
-0.0167748611420393,
0.0037607543636113405,
0.0739256888628006,
0.045356594026088715,
-0.028771352022886276,
-0.02136361412703991,
-0.02712799608707428,
0.007312929257750511,
0.026015572249889374,
-0.0014497865922749043,
0.020276470109820366,
-0.002021010499447584,
0.007698485627770424,
-0.01425926387310028,
0.08398807793855667,
0.007591035217046738,
0.0014987712493166327,
-0.003748113289475441,
0.012432611547410488,
-0.006320595741271973,
0.010454265400767326,
-0.01643354818224907,
-0.06558249890804291,
-0.010138235054910183,
0.022981686517596245,
0.0005289548425935209,
-0.024005621671676636,
-0.06290256977081299,
0.0008232576074078679,
0.002368643181398511,
0.046747125685214996,
0.035521745681762695,
0.00232913950458169,
-0.010915668681263924,
0.028796633705496788,
-0.018215956166386604,
-0.0073508527129888535,
0.005972962826490402,
0.02491578832268715,
0.002646749373525381,
0.005148125346750021,
0.0020146898459643126,
-0.02219793200492859,
-0.006134137976914644,
0.018721604719758034,
-0.003242465667426586,
0.03999672830104828,
-0.03309463709592819,
0.040249552577733994,
-0.02561105415225029,
-0.013589280657470226,
-0.01102943904697895,
0.015207353048026562,
0.020933812484145164,
0.01178791094571352,
-0.029201151803135872,
-0.02136361412703991,
-0.01424662210047245,
-0.004083104897290468,
-0.004057822283357382,
-0.006763037294149399,
0.013007786124944687,
-0.0262936782091856,
-0.009815884754061699,
0.023853927850723267,
0.022792067378759384,
-0.027734773233532906,
0.013500791974365711,
0.013715692795813084,
0.01625657267868519,
-0.04088161140680313,
0.04019898921251297,
-0.040123142302036285,
0.017545973882079124,
0.022160008549690247,
-0.00509123969823122,
-0.00268941349349916,
-0.039111845195293427,
-0.0420193187892437,
-0.007414058782160282,
0.00006552680133609101,
-0.025674259290099144,
-0.03582513704895973,
-0.0029785807710140944,
0.041463106870651245,
-0.015637153759598732,
-0.03673529997467995,
0.004920583683997393,
-0.019745539873838425,
0.02410675212740898,
0.004980629310011864,
0.00846959836781025,
-0.021098148077726364,
0.017722949385643005,
-0.010921989567577839,
0.00982852652668953,
0.00513232359662652,
-0.010068709030747414,
0.00873506348580122,
-0.007749050389975309,
-0.007275005336850882,
-0.018405575305223465,
-0.019100839272141457,
-0.02985849417746067,
-0.017179379239678383,
0.01576356589794159,
-0.011402354575693607,
-0.010049747303128242,
-0.013083633035421371,
0.002025750931352377,
0.013311174698174,
0.005615849047899246,
0.02614198438823223,
-0.026217831298708916,
-0.011250659823417664,
-0.009303917177021503,
0.044522274285554886,
0.0009346581064164639,
0.023992981761693954,
0.01102311909198761,
0.0016970799770206213,
-0.01484075840562582,
-0.028215138241648674,
-0.03847978636622429,
-0.0029043136164546013,
0.008874116465449333,
-0.007717447355389595,
0.014613216742873192,
0.00055660743964836,
0.04343513399362564,
0.01221771165728569,
0.0012562184128910303,
-0.03319576755166054,
0.004083104897290468,
-0.0038460823707282543,
0.0027605202049016953,
-0.004241119604557753,
0.017381638288497925,
0.007116990629583597,
0.006320595741271973,
0.05728987976908684,
-0.09308972954750061,
-0.050944000482559204,
-0.04699994996190071,
-0.017217302694916725,
-0.028897762298583984,
-0.019239893183112144,
0.0028411077801138163,
0.03172938898205757,
0.0010681806597858667,
-0.007116990629583597,
0.018936503678560257,
-0.03845450282096863,
0.003451045136898756,
0.0038776854053139687,
0.004974308889359236,
-0.03150184825062752,
-0.018911221995949745,
-0.04080576449632645,
-0.01008134987205267,
0.008931001648306847,
0.004797331988811493,
0.009683152660727501,
0.017887284979224205,
0.043182309716939926,
-0.029074739664793015,
-0.015245276503264904,
-0.025067482143640518,
-0.007496226578950882,
-0.020124776288866997,
-0.023310355842113495,
0.0042822035029530525,
0.015194712206721306,
-0.03711453825235367,
0.01591525971889496,
-0.013526074588298798,
-0.019568564370274544,
0.015118864364922047,
0.030768658965826035,
-0.007944989018142223,
-0.00018813647329807281,
-0.03478856012225151,
0.011851117014884949,
0.034839123487472534,
0.02561105415225029,
-0.008633933961391449,
-0.014613216742873192,
-0.038757894188165665,
0.007989232428371906,
-0.005429391749203205,
0.0005886054714210331,
-0.022147366777062416,
-0.03175467252731323,
-0.006990578956902027,
0.030768658965826035,
0.006007726304233074,
-0.027026867493987083,
-0.043637391179800034,
0.031072048470377922,
0.019783465191721916,
0.016825426369905472,
-0.028417397290468216,
0.027734773233532906,
0.035521745681762695,
-0.0012151345144957304,
-0.022084161639213562,
0.01575092412531376,
-0.029706798493862152,
0.035167794674634933,
-0.048415761440992355,
0.014866041019558907,
0.0033815186470746994,
0.013374380767345428,
-0.04828935116529465,
0.011655177921056747,
0.026192547753453255,
-0.005805467255413532,
-0.016016390174627304,
-0.010024464689195156,
-0.0076732030138373375,
-0.003830280853435397,
0.017545973882079124,
-0.0051986901089549065,
-0.022766785696148872,
-0.018734244629740715,
-0.02727968990802765,
-0.023651668801903725,
0.006876808125525713,
-0.027608361095190048,
0.005442033056169748,
-0.016357701271772385,
0.010068709030747414,
-0.01576356589794159,
0.013526074588298798,
0.01594054140150547,
-0.008368468843400478,
-0.022147366777062416,
-0.015295841731131077,
-0.00525557529181242,
0.00865289568901062,
-0.030414706096053123,
0.014082287438213825,
-0.003090771147981286,
0.01834236830472946,
-0.02442278154194355,
0.025345588102936745,
-0.021439461037516594,
0.0366341732442379,
-0.024625040590763092,
0.027557797729969025,
-0.0028158253990113735,
0.027709491550922394,
-0.020971735939383507,
0.006288992706686258,
-0.0006849945639260113,
-0.0022295902017503977,
0.01500509399920702,
0.008008195087313652,
0.002687833271920681,
0.017912568524479866,
0.01389266923069954,
0.031299591064453125,
0.02068098820745945,
-0.04007257521152496,
-0.011509804986417294,
-0.011149530299007893,
0.0006549716927111149,
0.001192222349345684,
0.03172938898205757,
0.027203842997550964,
0.0294792577624321,
0.02748194895684719,
0.05051419883966446,
-0.017874645069241524,
-0.0035995792131870985,
0.012666473165154457,
0.0018930183723568916,
0.011838475242257118,
0.029049457982182503,
0.009866449981927872,
0.03903599828481674,
-0.028114009648561478,
0.00004229367186781019,
-0.02394241653382778,
0.01102311909198761,
0.033676132559776306,
0.00007046476821415126,
-0.03592626377940178,
0.013210045173764229,
-0.02406882867217064,
0.019581206142902374,
0.014828117564320564,
0.008330545388162136,
0.014347751624882221,
0.053497523069381714,
-0.02851852774620056,
0.013222686015069485,
0.014448881149291992,
-0.03473799303174019,
0.013083633035421371,
0.023992981761693954,
0.01542225293815136,
0.03160297870635986,
-0.012868733145296574,
-0.0525873564183712,
-0.01441095769405365,
-0.014714346267282963,
-0.012072337791323662,
0.018355010077357292,
0.02829098515212536,
0.015611871145665646,
0.009512496180832386,
-0.0732683464884758,
0.05597519502043724,
-0.027102714404463768,
-0.026672912761569023,
0.0036817470099776983,
0.02490314655005932,
0.009607305750250816,
0.0021347810979932547,
0.048921409994363785,
-0.013652486726641655,
0.020048929378390312,
-0.0009868029737845063,
0.008697140030562878,
0.007382455747574568,
-0.008273659273982048,
-0.02052929438650608,
-0.02614198438823223,
0.002690993482246995,
-0.007869141176342964,
-0.0058497111313045025,
0.007161234971135855,
0.009784282185137272,
0.049755729734897614,
0.02677404321730137,
-0.03172938898205757,
0.007382455747574568,
0.05516615882515907,
-0.026723477989435196,
-0.025522565469145775,
-0.03764546662569046,
0.06457120180130005,
0.04075520113110542,
-0.007312929257750511,
0.001584889367222786,
0.014651140198111534,
0.018253879621624947,
-0.04803652688860893,
-0.02575010620057583,
0.020718911662697792,
-0.04457284137606621,
-0.002909054048359394,
-0.01238204725086689,
0.0074456618167459965,
0.03220975399017334,
-0.00035395336453802884,
0.0019562244415283203,
0.0010247265454381704,
-0.01357663981616497,
-0.03200749680399895,
-0.04090689495205879,
-0.04748031497001648,
-0.008532804436981678,
0.004917423240840435,
0.038429223001003265,
0.03122374229133129,
0.014284546487033367,
0.045533571392297745,
-0.021932465955615044,
0.005925558507442474,
0.006693510804325342,
0.036356065422296524,
0.03759490326046944,
0.018607834354043007,
-0.003748113289475441,
0.011851117014884949,
0.014360393397510052,
-0.016534678637981415,
0.00044204664300195873,
-0.009221749380230904,
0.06861638277769089,
0.05051419883966446,
0.001444256049580872,
-0.012015452608466148,
-0.020251188427209854,
-0.007679523900151253,
0.0356481596827507,
-0.01643354818224907,
-0.013614563271403313,
-0.020314393565058708,
-0.0023765440564602613,
-0.006127817556262016,
0.006712472531944513,
0.0569864884018898,
-0.0005095980013720691,
-0.01931574009358883,
-0.005457834340631962,
0.0071485936641693115,
0.020061571151018143,
0.00686416681855917,
-0.04151367023587227,
0.02473881095647812,
-0.01712881401181221,
0.03946579992771149,
-0.010378417558968067,
0.007761691231280565,
-0.015485459007322788,
-0.02119927853345871,
0.028695503249764442,
0.009518817067146301,
0.009158543311059475,
-0.0002567741903476417,
0.0006182332872413099,
-0.0016196526121348143,
-0.007230761460959911,
-0.04085633158683777,
0.012356764636933804,
-0.040426529943943024,
0.004045180976390839,
-0.02374015748500824,
-0.00026171214994974434,
-0.009525137953460217,
-0.04871915280818939,
-0.0021411017514765263,
0.011016798205673695,
-0.009386084042489529,
-0.005274537019431591,
-0.009954937733709812,
0.0014671682147309184,
-0.030616965144872665,
0.00047009429545141757,
0.022160008549690247,
0.0001465588138671592,
-0.0073445322923362255,
-0.017558613792061806,
-0.005400949157774448,
-0.010302570648491383,
-0.010258326306939125,
0.03170410916209221,
0.018355010077357292,
-0.035016100853681564,
0.010978874750435352,
0.015713000670075417,
0.018607834354043007,
0.024448063224554062,
-0.007888102903962135,
-0.017760872840881348,
-0.019897235557436943,
0.047050513327121735,
-0.008463277481496334,
-0.012268275953829288,
0.05170247331261635,
-0.019303098320961,
-0.00991069432348013,
-0.013058350421488285,
-0.03150184825062752,
-0.020453447476029396,
0.02524445950984955,
0.0002648724475875497,
-0.005742261186242104,
-0.02169228345155716,
-0.0016401945613324642,
-0.0020921172108501196,
0.0100939916446805,
-0.02664763107895851,
0.02118663676083088,
0.007483585271984339,
0.007622638251632452,
-0.00999918207526207,
0.011768949218094349,
0.023816004395484924,
-0.003032305743545294,
0.006089894101023674,
-0.0049679880030453205,
-0.021995672956109047,
0.029883775860071182,
-0.016926554962992668,
-0.0021189795807003975,
0.01442359946668148,
-0.03713981807231903,
0.0020178500562906265,
0.0027952834498137236,
0.011591972783207893,
0.02052929438650608,
0.02626839466392994,
-0.018076904118061066,
-0.014941887930035591,
-0.027052149176597595,
0.014903964474797249,
0.01212290208786726,
0.056025758385658264,
-0.007439340930432081,
-0.023828646168112755,
-0.00001567804065416567,
0.027431385591626167,
-0.005350384395569563,
-0.01212290208786726,
-0.0027131156530231237,
0.00019080298079643399,
-0.003466846654191613,
0.0015327443834394217,
0.04730333760380745,
0.02068098820745945,
-0.005476796068251133,
0.008494880050420761,
0.0014418858336284757,
-0.030136600136756897,
0.017596539109945297,
0.014347751624882221,
0.003090771147981286,
-0.014878681860864162,
0.005186048801988363,
-0.015144146978855133,
0.0035142512060701847,
-0.016319777816534042,
-0.008374788798391819,
0.0410333052277565,
0.03853034973144531,
-0.0016338740242645144,
0.012413649819791317,
-0.017558613792061806,
-0.007407737895846367,
0.005508399102836847,
-0.03193164989352226,
-0.0070537845604121685,
-0.020895889028906822,
-0.009183824993669987,
-0.026748761534690857,
0.0010618600063025951,
-0.00001765322667779401,
0.009158543311059475,
-0.013462868519127369,
0.013033067807555199,
0.013462868519127369,
-0.03981975093483925,
-0.012615908868610859,
-0.008008195087313652,
-0.00043375088716857135,
0.008077721111476421,
0.030768658965826035,
-0.023790722712874413,
-0.037746597081422806,
0.007888102903962135,
-0.0008106164168566465,
0.00288535188883543,
0.014600575901567936,
-0.02371487393975258,
0.013981157913804054,
0.0020131096243858337,
-0.0032867097761482,
-0.010075028985738754,
-0.01882273331284523,
-0.05278961360454559,
-0.0040609827265143394,
-0.0032551067415624857,
0.0050691175274550915,
0.010959913022816181,
-0.0009883831953629851,
-0.038606196641922,
0.012261955067515373,
-0.014524728991091251,
0.008703459985554218,
-0.014120210893452168,
0.008583368733525276,
-0.01697712019085884,
-0.011219057254493237,
0.005596887320280075,
-0.009360802359879017,
0.0003146471572108567,
0.005590566899627447,
0.00855176616460085,
0.015295841731131077,
0.036027394235134125,
0.004000937100499868,
-0.03769603371620178,
0.01558658853173256,
0.007932347245514393,
-0.00661766342818737,
-0.027001583948731422,
0.0045381877571344376,
-0.007287646643817425,
0.031072048470377922,
0.03521835803985596,
0.0349908173084259,
0.04396606236696243,
-0.025825953111052513,
-0.024157317355275154,
-0.014537369832396507,
0.050767023116350174,
0.0009070054511539638,
0.013943233527243137,
-0.0025851235259324312,
-0.027406102046370506,
0.004522386007010937,
-0.012419970706105232,
0.009461931884288788,
-0.008798269554972649,
-0.028265703469514847,
0.015826771035790443,
0.01576356589794159,
0.007761691231280565,
0.015068300068378448,
0.032336167991161346,
0.010896706953644753,
0.030288293957710266,
0.009329198859632015,
-0.01094095129519701,
0.00872242171317339,
-0.018102185800671577,
-0.01849406212568283,
0.015409612096846104,
0.02308281511068344,
0.019126122817397118,
-0.008627613075077534,
0.002934336429461837,
-0.03269011899828911,
0.00855808611959219,
0.034510452300310135,
-0.002822146052494645,
-0.008621292188763618,
-0.056885361671447754,
0.03160297870635986,
0.02834155037999153,
-0.008456956595182419,
0.020782118663191795,
0.010871424339711666,
0.009063733741641045,
-0.025168612599372864,
0.03218447417020798,
0.012356764636933804,
-0.018215956166386604,
-0.016168083995580673,
-0.008924680761992931,
-0.0038366015069186687,
0.015359047800302505,
0.020592501387000084,
-0.029555104672908783,
-0.025016916915774345,
-0.014347751624882221,
0.022324344143271446,
-0.040123142302036285,
-0.0054199108853936195,
-0.02066834829747677,
-0.008020835928618908,
0.03021244704723358,
-0.01178791094571352,
-0.034839123487472534,
-0.04937649145722389,
0.005318781360983849,
0.024561835452914238,
-0.022109443321824074,
-0.02054193615913391,
-0.027203842997550964,
0.009196466766297817,
0.03835337609052658,
0.0017555453814566135,
-0.0019988883286714554,
0.02626839466392994,
-0.0037733956705778837,
-0.008216774091124535,
0.004459180403500795,
-0.005407269578427076,
0.015232635661959648,
-0.01197120826691389,
-0.05203114449977875,
-0.006162580568343401,
-0.02152794785797596,
0.033878393471241,
0.007786973845213652,
0.004500264301896095,
0.01441095769405365,
-0.015257918275892735,
0.03734207898378372,
-0.0012269855942577124,
-0.025851236656308174,
0.025168612599372864,
0.007110670208930969,
0.000591765739955008,
-0.017545973882079124,
0.018708962947130203,
-0.0034226025454699993,
0.024549193680286407,
-0.0039598532021045685,
-0.023499974980950356,
-0.0066303047351539135,
-0.015359047800302505,
0.024802017956972122,
-0.010890386067330837,
0.014562652446329594,
0.006510213483124971,
0.02376543916761875,
-0.020984377712011337,
-0.013854745775461197,
0.004373852163553238,
-0.006914731580764055,
-0.004380172584205866,
-0.010669165290892124,
0.01949271745979786,
-0.011212736368179321,
0.016142800450325012,
-0.027052149176597595,
0.014486805535852909,
-0.012729679234325886,
0.015447535552084446,
-0.0035584953147917986,
-0.016142800450325012,
-0.0061120158061385155,
0.02932756394147873,
-0.009392404928803444,
0.008317903615534306,
0.0051702470518648624,
-0.01552338246256113,
0.024043545126914978,
-0.01782407984137535,
-0.032614272087812424,
0.012666473165154457,
-0.004395974334329367,
-0.010252006351947784,
0.013260609470307827,
-0.0021537430584430695,
-0.006775678601115942,
-0.03719038516283035,
-0.022943761199712753,
0.004279043059796095,
-0.021249841898679733,
-0.01966969296336174,
-0.037063971161842346,
-0.028771352022886276,
0.025889160111546516,
-0.0053314222022891045,
-0.018102185800671577,
-0.01415813434869051,
0.01313419733196497,
0.010599639266729355,
0.02748194895684719,
0.021490024402737617,
-0.0002717856259550899,
-0.00042822034447453916,
-0.043485697358846664,
-0.02659706585109234,
0.022690938785672188,
0.046873535960912704,
0.012514779344201088,
-0.014562652446329594,
0.021148713305592537,
0.004320126958191395,
-0.006396442651748657,
0.00015159553731791675,
-0.021768132224678993,
0.007831217721104622,
0.018380291759967804,
-0.015055659227073193,
-0.004686721600592136,
-0.000730818894226104,
-0.010422661900520325,
0.02068098820745945,
-0.03375197947025299,
-0.018708962947130203,
0.0222232136875391,
-0.006222626194357872,
-0.014196057803928852,
0.04811237379908562,
-0.02745666727423668,
-0.003289869986474514,
-0.055722370743751526,
-0.0019293618388473988,
-0.04667127877473831,
-0.027026867493987083,
0.04310646280646324,
0.021148713305592537,
-0.018772168084979057,
0.01778615638613701,
0.031249023973941803,
-0.024485986679792404,
-0.019252534955739975,
-0.02983321063220501,
-0.007869141176342964,
0.013285892084240913,
-0.026748761534690857,
0.00814092718064785,
-0.006364839617162943,
0.012748640961945057,
-0.03413121774792671,
0.020428165793418884,
-0.006187863182276487,
0.022855274379253387,
-0.017899926751852036,
-0.041311413049697876,
-0.009980220347642899,
-0.019909875467419624,
-0.040375966578722,
0.008267339318990707,
0.009771640412509441,
0.032968226820230484,
0.026217831298708916,
0.00500591192394495,
-0.03544589877128601,
0.0379488542675972,
-0.026167266070842743,
-0.014373034238815308,
0.056379713118076324,
-0.0044180965051054955,
-0.02917587012052536,
0.03104676492512226,
0.01077661570161581,
-0.015814131125807762,
0.0009346581064164639,
0.01230619940906763,
-0.0024745131377130747,
0.0159531831741333,
-0.030945636332035065,
0.02308281511068344,
-0.0256363358348608,
-0.005701177287846804,
0.08803325891494751,
-0.003966173622757196,
0.02037760056555271,
0.05038778856396675,
-0.018102185800671577,
0.00113375682849437,
0.0009512496180832386,
0.00437069172039628,
0.007275005336850882,
-0.0013984318356961012,
0.007616317830979824,
0.01500509399920702,
0.0009465091861784458,
0.04952818900346756,
0.0036564646288752556,
-0.021806055679917336,
-0.0037986780516803265,
0.03557231277227402,
-0.0556718073785305,
-0.0028948327526450157,
-0.007723767776042223,
0.0006529965321533382,
-0.028796633705496788,
0.0259650070220232,
-0.023525256663560867,
-0.001533534494228661,
0.00618470273911953,
-0.02813929133117199,
-0.034662146121263504,
-0.02952982299029827,
-0.004500264301896095,
0.004860538057982922,
0.02357582189142704,
0.0020273311529308558,
-0.005252414848655462,
-0.013715692795813084,
0.0003952347324229777,
-0.013639844954013824,
0.0009654709720052779,
0.028366833925247192,
-0.05552011355757713,
0.008975245989859104,
0.016243930906057358,
-0.001142447697930038,
0.0057232994586229324,
-0.009449290111660957,
-0.03865676373243332,
0.00729396753013134,
0.014398316852748394,
-0.004427577368915081,
0.009898052550852299,
-0.005890795029699802,
-0.0041147079318761826,
0.04227214306592941,
-0.022286420688033104,
-0.018759528174996376,
-0.020718911662697792,
-0.01329853292554617,
-0.001253848196938634,
-0.02985849417746067,
0.0007237081881612539,
0.01357663981616497,
0.013981157913804054,
0.003609060076996684,
0.020731553435325623
] | 2024-07-15 | 41 | 39007104 | [
"AL amyloidosis",
"autologous stem cell transplant",
"T cells",
"treatment paradigms",
"new treatments",
"AL",
"front therapy",
"BCMA)-directed therapies",
"Treatments",
"organ involvement",
"organ recovery",
"chimeric antigen receptor",
"bispecific antibodies",
"antibody drug conjugates",
"patients",
"relapsed and refractory AL amyloidosis",
"MM",
"specifically B cell maturation antigen",
"multiple myeloma",
"AL) amyloidosis",
"promising results",
"ASCT",
"a plasma cell disorder",
"misfolded proteins",
"Particular attention",
"the treatment paradigm",
"Light chain",
"quality",
"CAR",
"life"
] | [
"AL amyloidosis",
"CAR T cell therapy",
"bispecific antibodies",
"daratumumab",
"stem cell transplant"
] | 0 | 10.3389/fonc.2024.1425521
10.1038/s41375-019-0655-x
10.1097/CCO.0000000000000881
10.1038/s41572-018-0034-3
10.1182/blood.2020006913
10.1182/blood.V88.7.2801.bloodjournal8872801
10.7326/0003-4819-140-2-200401200-00008
10.1002/ajh.26641
10.1080/13506129.2021.2002841
10.1182/blood-2015-08-662726
10.1038/bmt.2017.68
10.1182/blood.v128.22.4627.4627
10.1016/j.bbmt.2018.06.018
10.1038/leu.2012.274
10.1111/j.1365-2141.2007.06783.x
10.1038/leu.2016.229
10.1056/nejmoa070484
10.1016/j.bbmt.2015.08.026
10.1038/s41409-018-0388-x
10.1016/j.bbmt.2019.12.707
10.1200/jco.2015.62.4015
10.1016/j.bbmt.2015.04.001
10.1016/j.bbmt.2018.07.010
10.1016/j.clml.2014.02.003
10.1186/1741-7015-12-2
10.1056/nejmoa2028631
10.1111/bjh.19042
10.1056/nejmoa2024850
10.1200/jco.22.00842
10.1016/s0140-6736(21)00933-8
10.1182/hematology.2021000305
10.1136/jitc-2021-003783
10.3390/curroncol30110697
10.1111/bjh.17527
10.1158/1078-0432.ccr-22-0637
10.1182/blood-2023-186450
10.1056/nejmoa2203478
10.1038/s41591-023-02528-9
10.1002/jha2.772
10.1038/s41408-023-00950-3
10.1182/blood.2023022937
10.1136/bmj.m3176
10.1007/s00277-022-04890-z
10.1111/bjh.19286
10.1182/blood-2022-169688 | [
"Sarubbi",
"Abowali",
"Varga",
"Landau"
] | [
"Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States.",
"Department of Hematology/Oncology, Brookdale University Medical Center, Brooklyn, NY, United States.",
"Department of Hematology, Levine Cancer Institute Atrium Health, Charlotte, NC, United States.",
"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States."
] | [
"39007104",
"31758090",
"35943427",
"30361521",
"33270858",
"8839879",
"14734330",
"35731907",
"34783272",
"26443620",
"28394369",
"29933072",
"23014566",
"17897298",
"27560108",
"17855669",
"26327631",
"30390060",
"26371138",
"25858810",
"30016656",
"24650974",
"24386911",
"34192431",
"37580907",
"33626253",
"35658469",
"34175021",
"34889374",
"34876408",
"37999117",
"34296427",
"36107221",
"35661166",
"37582952",
"38024617",
"38012151",
"38096365",
"32958461",
"35821344",
"38171355"
] | [] | 5.013083 | 6.565833 |
39001421 | 730 | The Immunotherapy of Acute Myeloid Leukemia: A Clinical Point of View. | The potential of the immune system to eradicate leukemic cells has been consistently demonstrated by the | [
0.012450089678168297,
0.009494190104305744,
-0.026586011052131653,
0.06100885570049286,
-0.061555612832307816,
-0.021027324721217155,
-0.00524259265512228,
0.040573850274086,
0.015457247383892536,
-0.0022539447527378798,
-0.004752790555357933,
-0.0015947050414979458,
-0.03296482935547829,
0.003195105353370309,
0.05194181948900223,
-0.011134457774460316,
0.01404479518532753,
-0.015947049483656883,
0.0025244748685508966,
-0.005188486538827419,
0.04002709686756134,
0.033853307366371155,
0.03619980439543724,
0.00361656304448843,
-0.006726237945258617,
-0.026768263429403305,
-0.025697533041238785,
0.00824690330773592,
0.03496960178017616,
0.004066497553139925,
0.022530904039740562,
-0.03761225566267967,
0.019079506397247314,
0.024672364816069603,
-0.017234204337000847,
0.02292957901954651,
0.026836607605218887,
-0.015445857308804989,
-0.058229513466358185,
0.013087972067296505,
0.0031039793975651264,
0.014170093461871147,
-0.00861140713095665,
0.0761813372373581,
-0.02904641255736351,
0.013851151801645756,
-0.026380976662039757,
-0.10616178810596466,
0.04255584254860878,
-0.006936966907233,
-0.005137228406965733,
0.03314708173274994,
-0.01584453321993351,
0.0035197418183088303,
-0.0036080200225114822,
0.030048798769712448,
-0.01423843763768673,
0.019762951880693436,
-0.0015648043481633067,
-0.03934365138411522,
0.025583624839782715,
0.010832603089511395,
0.02288401685655117,
-0.02254229411482811,
-0.07581683248281479,
-0.026472102850675583,
-0.013554992154240608,
-0.03872855007648468,
0.03319264575839043,
0.009380282834172249,
0.006213654298335314,
-0.041690144687891006,
-0.013760026544332504,
0.03321542590856552,
0.008298161439597607,
0.002394905313849449,
0.00790518056601286,
-0.006356038618832827,
-0.0239205751568079,
-0.012609560042619705,
0.009420149959623814,
-0.004917956423014402,
0.03945755958557129,
-0.039890408515930176,
-0.003670669160783291,
0.005111598875373602,
0.04255584254860878,
-0.0067718010395765305,
-0.030094360932707787,
0.025355810299515724,
0.0067718010395765305,
0.0020104674622416496,
-0.0004563419206533581,
0.021676598116755486,
0.006959748454391956,
0.014671285636723042,
0.025082431733608246,
-0.06023428589105606,
0.05522235482931137,
0.08834666013717651,
0.060143161565065384,
0.0093745868653059,
-0.019147850573062897,
-0.038136232644319534,
0.010348496027290821,
0.011373664252460003,
-0.013885323889553547,
-0.027884555980563164,
-0.0031694762874394655,
-0.0029615950770676136,
0.07007589191198349,
0.0036308015696704388,
0.009385977871716022,
0.029843764379620552,
-0.00870822835713625,
-0.023396600037813187,
-0.03574417531490326,
-0.023089051246643066,
0.04852459579706192,
0.020195798948407173,
0.011846380308270454,
0.040049877017736435,
-0.03039052151143551,
-0.019569309428334236,
-0.01886308193206787,
-0.0497547946870327,
0.0558602400124073,
-0.033807747066020966,
-0.008093127980828285,
-0.0267910435795784,
0.027178330346941948,
-0.013486647978425026,
0.02651766687631607,
0.008628493174910545,
-0.053718775510787964,
0.00574948126450181,
0.02578865736722946,
-0.05545017123222351,
0.013236051425337791,
0.01102055050432682,
0.047704461961984634,
0.014295391738414764,
-0.014420690014958382,
-0.007722928654402494,
-0.013794198632240295,
-0.03478734940290451,
0.015434466302394867,
0.0020005004480481148,
0.0685267522931099,
-0.013406912796199322,
0.023396600037813187,
0.04775002598762512,
0.04925360158085823,
0.029752640053629875,
-0.030185487121343613,
-0.050574928522109985,
0.021232357248663902,
0.04638313502073288,
-0.023966137319803238,
-0.01660771295428276,
-0.008326638489961624,
0.014318172819912434,
-0.04811452701687813,
-0.029456479474902153,
0.006145309656858444,
0.03784007206559181,
0.005951666738837957,
0.035721391439437866,
-0.048661284148693085,
-0.00017531076446175575,
0.025082431733608246,
0.008013392798602581,
-0.027679523453116417,
-0.041804052889347076,
-0.03455953672528267,
0.033967215567827225,
0.024968523532152176,
0.06356038898229599,
-0.028727471828460693,
-0.0077172331511974335,
0.04610975459218025,
0.012996845878660679,
0.030094360932707787,
0.018191028386354446,
-0.014261218719184399,
-0.007728623691946268,
-0.014910492114722729,
0.01997937634587288,
-0.02097037062048912,
-0.01576479896903038,
0.02724667452275753,
-0.00011995883687632158,
0.03806788846850395,
-0.013805588707327843,
0.01226783823221922,
-0.0029217274859547615,
0.026130380108952522,
0.029479261487722397,
-0.005974448285996914,
-0.05321758612990379,
-0.013543602079153061,
0.015320559032261372,
-0.027269456535577774,
-0.022815672680735588,
-0.006378820165991783,
0.03900192677974701,
0.001404621871188283,
0.010952206328511238,
-0.03697437420487404,
0.007734319195151329,
0.010189025662839413,
0.018316326662898064,
0.02242838777601719,
-0.04513015225529671,
0.007802663836628199,
-0.016425462439656258,
0.0010757140116766095,
0.052716393023729324,
0.03845517337322235,
0.023202957585453987,
0.01886308193206787,
-0.010576311498880386,
0.03207635134458542,
0.016402680426836014,
-0.012563996948301792,
0.004137690179049969,
-0.0018865929450839758,
0.009841607883572578,
-0.013771416619420052,
-0.03068668022751808,
0.011584392748773098,
-0.0310056209564209,
-0.009397368878126144,
-0.035265762358903885,
-0.03348880633711815,
0.0003358491521794349,
-0.009972602128982544,
0.044833991676568985,
0.032167479395866394,
-0.025424154475331306,
-0.0032662975136190653,
0.015013008378446102,
0.03665543347597122,
-0.003909875173121691,
-0.04993704706430435,
0.009323328733444214,
-0.004473716951906681,
-0.010735781863331795,
0.0034969602711498737,
-0.012769030407071114,
-0.0355847030878067,
0.049845922738313675,
-0.007386901415884495,
-0.0447884276509285,
-0.004285769537091255,
0.014340953901410103,
0.0333065539598465,
0.009647965431213379,
-0.007358424365520477,
-0.011373664252460003,
-0.021915802732110023,
0.025173557922244072,
-0.061099983751773834,
-0.03615424036979675,
-0.007574848830699921,
0.025196339935064316,
-0.0020987456664443016,
0.030937276780605316,
0.03203079104423523,
-0.002681097714230418,
0.005567228887230158,
0.010342800989747047,
0.00912399124354124,
-0.018122684210538864,
-0.03574417531490326,
0.024398986250162125,
0.0077115376479923725,
0.055586859583854675,
-0.044218890368938446,
0.04000431299209595,
-0.014135920442640781,
-0.024057263508439064,
0.03820457682013512,
-0.017279768362641335,
-0.009653660468757153,
-0.0016288772458210588,
-0.03563026711344719,
-0.0002655468706507236,
-0.012404526583850384,
-0.005940276198089123,
-0.028955286368727684,
-0.007170476950705051,
0.010935120284557343,
-0.04237359017133713,
-0.02346494421362877,
0.04633757099509239,
0.0072160400450229645,
-0.006338952574878931,
-0.0317574106156826,
0.035151854157447815,
0.014022013172507286,
-0.01832771673798561,
-0.007079351227730513,
-0.0351974181830883,
-0.010935120284557343,
0.05504010617733002,
0.028681907802820206,
0.0030299394857138395,
-0.02319156751036644,
0.05112168565392494,
0.02112984098494053,
0.00487808883190155,
0.0020845073740929365,
0.03146125003695488,
0.013680290430784225,
-0.03663265332579613,
-0.010365583002567291,
-0.035425230860710144,
0.006908489856868982,
-0.029638731852173805,
-0.08588625490665436,
0.030527209863066673,
-0.029957672581076622,
0.004126299172639847,
-0.0482056550681591,
0.026494884863495827,
-0.013999232091009617,
0.002820634515956044,
0.026358196511864662,
-0.025082431733608246,
0.009385977871716022,
-0.04225968196988106,
0.03952590376138687,
0.0011739592300727963,
0.004909413401037455,
-0.02510521374642849,
-0.01592426933348179,
0.03296482935547829,
-0.0017128840554505587,
0.02674548141658306,
0.014204265549778938,
0.01925036683678627,
-0.027565615251660347,
0.0067718010395765305,
0.02859078347682953,
-0.007665975019335747,
-0.018236590549349785,
-0.01458016037940979,
0.03353436663746834,
0.013760026544332504,
0.007011006586253643,
-0.0000855196121847257,
-0.0040892791002988815,
0.03772616386413574,
0.017279768362641335,
-0.019649043679237366,
0.014181483536958694,
-0.004459478426724672,
-0.0028362968005239964,
-0.007381205912679434,
0.011100285686552525,
0.002467521233484149,
-0.033693838864564896,
0.0516684427857399,
0.012461480684578419,
0.042692530900239944,
-0.05590580031275749,
-0.014933273196220398,
-0.04321650415658951,
-0.03697437420487404,
-0.007819750346243382,
0.049116913229227066,
0.022940970957279205,
0.020378051325678825,
-0.01458016037940979,
0.01936427503824234,
0.009573925286531448,
-0.025287464261054993,
0.003613715525716543,
0.0197059977799654,
0.03797676041722298,
0.012552606873214245,
0.016744403168559074,
-0.019967984408140182,
-0.010376973077654839,
0.04378604143857956,
-0.013349958695471287,
-0.027656741440296173,
-0.09704919159412384,
0.024695146828889847,
0.006600939668715,
0.000765316013712436,
0.011447703465819359,
0.0018808975582942367,
0.02108427882194519,
0.023715540766716003,
-0.059641968458890915,
0.07267298549413681,
0.052716393023729324,
0.009927039034664631,
-0.027952900156378746,
-0.06916463375091553,
-0.017780961468815804,
-0.0037532520946115255,
0.03383052721619606,
-0.052944205701351166,
-0.008064650930464268,
0.02483183518052101,
0.04595028609037399,
0.0009739091037772596,
-0.007637497968971729,
0.03433172032237053,
0.013236051425337791,
-0.06164674088358879,
0.008326638489961624,
-0.01513830665498972,
-0.03736165910959244,
0.00461040623486042,
-0.03203079104423523,
0.0015591089613735676,
-0.005550142843276262,
-0.019387057051062584,
-0.00443954486399889,
0.03057277388870716,
0.03219025954604149,
0.015400294214487076,
0.04358100891113281,
0.006954052951186895,
0.013771416619420052,
-0.06793443113565445,
-0.04105226323008537,
0.04389994964003563,
-0.01936427503824234,
0.0004570538585539907,
-0.012700686231255531,
0.02752005308866501,
-0.030185487121343613,
0.017803741618990898,
-0.02410282753407955,
-0.030367739498615265,
0.04223690181970596,
-0.01096359733492136,
-0.03403555974364281,
-0.01637989841401577,
-0.010769953951239586,
0.042806439101696014,
-0.03663265332579613,
-0.0006083372281864285,
-0.02284984476864338,
0.00002382713500992395,
0.05481228977441788,
-0.05686262249946594,
0.0021144079510122538,
-0.0021685140673071146,
-0.029023630544543266,
-0.032167479395866394,
0.0035710001830011606,
-0.03604033216834068,
0.05481228977441788,
0.021494345739483833,
0.041234515607357025,
-0.01584453321993351,
-0.007011006586253643,
-0.00847471784800291,
-0.005162857472896576,
0.035653047263622284,
0.027793429791927338,
-0.027178330346941948,
0.0352201983332634,
-0.0049065654166042805,
0.04692988842725754,
-0.04339875653386116,
-0.00308119785040617,
-0.0017897716024890542,
-0.006242130883038044,
0.040437161922454834,
0.030139924958348274,
0.0017470562597736716,
0.07089602947235107,
0.0018025862518697977,
-0.01623181812465191,
-0.04182683303952217,
-0.04560856148600578,
-0.0401865653693676,
0.02176772430539131,
-0.03918417915701866,
-0.01610651984810829,
0.003027091734111309,
-0.012962673790752888,
-0.005302394274622202,
0.022713156417012215,
-0.0004374760028440505,
0.015331950038671494,
-0.008674056269228458,
0.0020702688489109278,
-0.02836296707391739,
0.014113139361143112,
-0.010638960637152195,
-0.0022069578990340233,
0.003368814243003726,
0.02108427882194519,
-0.00002994521491928026,
0.01798599399626255,
-0.005883322563022375,
0.05494897812604904,
0.02471792697906494,
-0.008793659508228302,
0.03629092872142792,
-0.007352729327976704,
0.03196244314312935,
-0.02155129984021187,
-0.023783886805176735,
0.030914494767785072,
-0.013691681437194347,
-0.025014087557792664,
-0.0172228142619133,
-0.041849616914987564,
-0.004066497553139925,
-0.018498579040169716,
-0.005390672478824854,
0.014284000732004642,
-0.0026782501954585314,
-0.028750253841280937,
-0.012632342055439949,
0.009311937727034092,
-0.024193953722715378,
-0.020252753049135208,
-0.0036080200225114822,
0.0018239438068121672,
-0.02651766687631607,
0.006441469304263592,
-0.017769569531083107,
0.002503117313608527,
0.02077672816812992,
0.017769569531083107,
-0.028978068381547928,
-0.015707844868302345,
0.03471900522708893,
0.0007375510758720338,
-0.009112600237131119,
0.014227046631276608,
0.01824798248708248,
0.017940431833267212,
-0.02633541449904442,
0.004473716951906681,
0.039548683911561966,
-0.00448795547708869,
-0.028294622898101807,
-0.0006026418996043503,
-0.0020332487765699625,
0.01963765360414982,
-0.00861140713095665,
-0.0012159625766798854,
-0.029297009110450745,
0.02847687527537346,
0.010707304812967777,
-0.04811452701687813,
-0.025811439380049706,
-0.0002982952573802322,
-0.0015975526766851544,
-0.030823370441794395,
-0.011128762736916542,
0.02476349100470543,
-0.010416841134428978,
0.01910228841006756,
0.009180944412946701,
-0.0015477181877940893,
0.000007769959665893111,
-0.034468408674001694,
0.032281383872032166,
-0.03073224425315857,
0.032235823571681976,
-0.020286925137043,
-0.020195798948407173,
0.03348880633711815,
0.02556084282696247,
0.0067148469388484955,
-0.006253521889448166,
-0.005393519997596741,
-0.018532751128077507,
0.01322466041892767,
0.01871500164270401,
-0.05945971608161926,
0.028044026345014572,
0.0099498201161623,
-0.00006763257988495752,
-0.04310259968042374,
-0.020788118243217468,
-0.03508350998163223,
-0.016277382150292397,
0.02166520617902279,
-0.008178558200597763,
0.024740708991885185,
-0.01940983720123768,
-0.00924359355121851,
0.008674056269228458,
0.04244193434715271,
-0.018225200474262238,
-0.021061496809124947,
-0.035379670560359955,
-0.009477104060351849,
0.015662280842661858,
0.011322405189275742,
-0.039434775710105896,
0.020537521690130234,
0.024330642074346542,
-0.0011504658032208681,
0.013828370720148087,
-0.03150681406259537,
0.006168091204017401,
0.014386516995728016,
0.02758839726448059,
-0.02449011243879795,
-0.0019350036745890975,
0.029707076027989388,
-0.0030840456020087004,
0.004388286266475916,
0.012199493125081062,
0.043877169489860535,
-0.003047025529667735,
-0.0042288159020245075,
0.00434272363781929,
0.006418687757104635,
-0.02628985047340393,
0.00609405105933547,
-0.03569861128926277,
0.017541754990816116,
0.002477488247677684,
0.004163319244980812,
0.014648504555225372,
0.013179098255932331,
-0.04733995720744133,
-0.0006781055708415806,
0.032281383872032166,
0.025993691757321358,
-0.03266867250204086,
0.021482953801751137,
-0.015047180466353893,
0.008463326841592789,
-0.021938584744930267,
0.014705458655953407,
-0.0011390750296413898,
-0.02836296707391739,
-0.023510508239269257,
0.009761872701346874,
-0.004633187782019377,
-0.03362549468874931,
-0.024786273017525673,
0.0317574106156826,
-0.0018552683759480715,
0.010348496027290821,
-0.020765338093042374,
0.037908416241407394,
-0.005094512831419706,
-0.00841776467859745,
-0.024171171709895134,
-0.004052259493619204,
-0.014511815272271633,
0.03631371259689331,
0.054857853800058365,
-0.027998464182019234,
-0.0035909339785575867,
0.030208269134163857,
-0.01622042804956436,
0.0038671595975756645,
0.004710074979811907,
-0.004112060647457838,
0.0055472953245043755,
0.016698839142918587,
0.017940431833267212,
0.05731825530529022,
0.026244288310408592,
0.006936966907233,
-0.003795967437326908,
-0.013498038984835148,
0.03403555974364281,
-0.023066269233822823,
-0.010268760845065117,
-0.05850289389491081,
0.0019264606526121497,
-0.00793935265392065,
0.01772400736808777,
-0.040505506098270416,
-0.036792121827602386,
-0.06219349429011345,
-0.028226278722286224,
0.0497547946870327,
-0.0026640116702765226,
-0.010490881279110909,
-0.029820984229445457,
-0.007159086409956217,
-0.007005311083048582,
-0.0017954669892787933,
-0.020412223413586617,
0.015445857308804989,
0.004764181096106768,
-0.007654584012925625,
0.005296698771417141,
-0.02556084282696247,
0.008338029496371746,
0.022485340014100075,
0.010593397542834282,
0.04756777361035347,
-0.008736705407500267,
0.02169937826693058,
-0.026996077969670296,
0.0019478182075545192,
-0.02437620423734188,
0.003670669160783291,
0.002629839349538088,
-0.026198724284768105,
0.03362549468874931,
-0.024922961369156837,
-0.028978068381547928,
0.0010600517271086574,
-0.009516972117125988,
-0.010519357398152351,
0.015821751207113266,
-0.018350498750805855,
0.00008823382086120546,
0.005812130402773619,
0.004020934924483299,
0.0048125917091965675,
-0.019876858219504356,
0.023054877296090126,
0.04228246584534645,
-0.0037475568242371082,
0.06880012899637222,
-0.012393136508762836,
-0.023738322779536247,
0.013554992154240608,
-0.04513015225529671,
0.01038836408406496,
-0.014227046631276608,
0.018156856298446655,
0.03879689425230026,
-0.008503194898366928,
-0.01952374540269375,
-0.03756669536232948,
-0.004764181096106768,
0.041462332010269165,
-0.02786177396774292,
-0.001590433530509472,
0.0397992804646492,
-0.012700686231255531,
0.017587319016456604,
-0.0038272920064628124,
-0.006561072077602148,
0.021334875375032425,
-0.009619488380849361,
0.000619372061919421,
0.007142000366002321,
0.006031402386724949,
0.01511552557349205,
-0.001352651626802981,
-0.02865912765264511,
0.001258677919395268,
0.014420690014958382,
-0.0016616256907582283,
-0.022781500592827797,
-0.014659895561635494,
0.05157731473445892,
-0.014363735914230347,
-0.0390474908053875,
0.01025737076997757,
-0.019273148849606514,
-0.003195105353370309,
0.017929039895534515,
0.002275302307680249,
-0.005854845512658358,
0.01337274070829153,
0.00548179866746068,
0.011891943402588367,
-0.014033404178917408,
-0.02315739542245865,
0.044492270797491074,
-0.010126376524567604,
-0.02269037440419197,
-0.01817963644862175,
0.0208564642816782,
-0.0019933811854571104,
0.0029644425958395004,
-0.028112370520830154,
-0.012825984507799149,
-0.010097899474203587,
-0.027155548334121704,
0.00616239570081234,
0.01920480467379093,
-0.048433467745780945,
-0.04779558628797531,
-0.020264144986867905,
0.03296482935547829,
-0.011755254119634628,
0.04271531105041504,
-0.004026629962027073,
0.03282814100384712,
0.002097321907058358,
-0.06916463375091553,
-0.02004772052168846,
-0.015400294214487076,
0.006139614153653383,
-0.04011822119355202,
0.01530916802585125,
-0.025082431733608246,
0.007757100742310286,
-0.001987685915082693,
-0.0037219275254756212,
0.041690144687891006,
-0.004698684439063072,
0.02449011243879795,
-0.041690144687891006,
0.03321542590856552,
-0.030641118064522743,
-0.026996077969670296,
0.01829354465007782,
-0.009357500821352005,
0.01218810211867094,
-0.02831740491092205,
0.0070337881334125996,
-0.005051797721534967,
-0.016562150791287422,
-0.007745710201561451,
0.03130178153514862,
-0.024900179356336594,
-0.01460294146090746,
-0.033010393381118774,
0.0013861119514331222,
-0.014990227296948433,
-0.009784654714167118,
-0.0072160400450229645,
0.025538060814142227,
-0.028385749086737633,
-0.042692530900239944,
0.01821380853652954,
0.0011874856427311897,
-0.010764258913695812,
0.010006774216890335,
-0.05444778501987457,
0.04369491711258888,
-0.02166520617902279,
-0.02460402064025402,
-0.015753407031297684,
0.007386901415884495,
-0.04205464944243431,
0.03508350998163223,
0.03567582741379738,
-0.02226891554892063,
-0.001062899362295866,
-0.006344647612422705,
-0.05139506608247757,
0.0034770264755934477,
-0.03811344876885414,
-0.060325413942337036,
-0.02476349100470543,
0.032053571194410324,
-0.01779235154390335,
-0.009266375564038754,
-0.04007265716791153,
0.021722160279750824,
0.01887447200715542,
-0.001972023630514741,
-0.004072193056344986,
0.0074837226420640945,
-0.05098499730229378,
0.025127993896603584,
-0.026540447026491165,
-0.011880552396178246,
-0.00470722746104002,
0.05690818652510643,
-0.029638731852173805,
0.03387609124183655,
0.008947433903813362,
-0.031210655346512794,
-0.007147695869207382,
-0.009477104060351849,
-0.014261218719184399,
0.011601478792726994,
-0.024125609546899796,
-0.009471409022808075,
-0.016391288489103317,
0.015787579119205475,
-0.006880013272166252,
0.015548373572528362,
0.003007157938554883,
-0.012313400395214558,
0.009272070601582527,
-0.0340583436191082,
0.013862542808055878,
-0.02931979112327099,
-0.013327177613973618,
0.008924652822315693,
0.015274995937943459,
-0.04075610265135765,
-0.02572031319141388,
-0.007028092630207539,
-0.023966137319803238,
-0.005330870859324932,
0.029912110418081284,
-0.032121915370225906,
-0.001540598925203085,
0.00531093729659915,
0.014147311449050903,
-0.003989610355347395,
-0.0006926999776624143,
-0.00616239570081234,
0.03756669536232948,
-0.0029359657783061266,
0.02292957901954651,
0.003340337425470352,
-0.0016345726326107979,
-0.0015747712459415197,
0.005347957368940115,
0.004388286266475916,
0.010285846889019012,
-0.019876858219504356,
-0.029684294015169144,
0.0028263297863304615,
0.03715662658214569,
0.007290080189704895,
-0.0026825217064470053,
-0.03376218304038048,
-0.0021841763518750668,
0.0008920381078496575,
0.02184745855629444,
0.012563996948301792,
-0.0444011427462101,
-0.01913646049797535,
0.036450400948524475,
0.0235332902520895,
-0.014363735914230347,
-0.012917110696434975,
-0.03451397269964218,
0.012780421413481236,
-0.0004403236962389201,
0.03856908157467842,
0.04565412551164627,
0.02410282753407955,
0.010126376524567604,
0.0015035789692774415,
-0.01920480467379093,
0.012917110696434975,
0.01530916802585125,
-0.026586011052131653,
-0.0105250533670187,
0.01440929900854826,
0.012290619313716888,
-0.000547467905562371,
-0.02273593656718731,
0.008867698721587658,
0.0394119955599308,
0.03310152143239975,
-0.016641885042190552,
0.02900085039436817,
0.017211424186825752,
-0.02414838969707489,
-0.014785193838179111,
0.013133535161614418,
-0.024854617193341255,
0.025515280663967133,
-0.05385546758770943,
-0.036792121827602386,
-0.00257288571447134,
-0.021517127752304077,
-0.02802124433219433,
0.028044026345014572,
0.034924041479825974,
0.009944125078618526,
0.023373819887638092,
-0.0822867751121521,
0.021949974820017815,
-0.01289432868361473,
-0.0005638421280309558,
0.029570387676358223,
0.0030555687844753265,
0.006885708309710026,
0.02341938205063343,
0.014067576266825199,
-0.014899101108312607,
0.02713276632130146,
0.013999232091009617,
-0.011698300018906593,
0.014864929020404816,
0.010200416669249535,
0.022667592391371727,
0.013429693877696991,
0.024786273017525673,
0.006805973127484322,
-0.0013505157548934221,
-0.043489884585142136,
0.005273917224258184,
0.022872626781463623,
0.06656754016876221,
-0.03856908157467842,
-0.05813838914036751,
0.05043824017047882,
-0.050301551818847656,
-0.02161964401602745,
-0.026859387755393982,
0.03843238949775696,
0.022633420303463936,
-0.032782576978206635,
-0.0034257681109011173,
0.04788671433925629,
0.006805973127484322,
-0.03708828240633011,
-0.01337274070829153,
0.022644810378551483,
0.018509969115257263,
0.0005709613324142992,
0.01879473775625229,
0.040619414299726486,
0.018806127831339836,
-0.016584932804107666,
0.011180020868778229,
-0.009892866015434265,
-0.016676058992743492,
-0.024558456614613533,
0.034878477454185486,
-0.04102948307991028,
0.05235188826918602,
-0.0038472258020192385,
0.007050874177366495,
-0.00439113425090909,
0.03187131881713867,
0.007050874177366495,
-0.020161626860499382,
0.03984484449028969,
-0.03592642396688461,
0.025925347581505775,
-0.018042948096990585,
0.03663265332579613,
0.005034711677581072,
0.0023721237666904926,
0.0198996402323246,
-0.006623721215873957,
0.004337028134614229,
-0.03198522701859474,
0.01852135919034481,
0.011812208220362663,
-0.014135920442640781,
-0.021482953801751137,
0.02231447957456112,
0.011800817213952541,
0.03708828240633011,
-0.02288401685655117,
-0.04130285978317261,
-0.020571693778038025,
-0.0243078600615263,
-0.0025956672616302967,
0.0025187795981764793,
0.035493578761816025,
0.012005850672721863,
0.02284984476864338,
0.010451013222336769,
-0.03287370502948761,
0.02223474346101284,
0.020298317074775696,
-0.008674056269228458,
-0.04342154040932655,
-0.04970923438668251,
-0.010787039995193481,
-0.009881475940346718,
0.013190488331019878,
-0.019626261666417122,
-0.0302310511469841,
0.04125729575753212,
0.0012622374342754483,
0.019728779792785645,
0.026973295956850052,
-0.003989610355347395,
0.005906104110181332,
-0.03731609880924225,
0.00008725492807570845,
0.027383362874388695,
-0.003841530531644821,
-0.005598553456366062,
-0.05257970094680786,
0.012484261766076088,
-0.026882169768214226,
0.007984915748238564,
0.007779882289469242,
0.009835912846028805,
0.012734858319163322,
-0.017632881179451942,
-0.03918417915701866,
0.0026967599987983704,
-0.022371433675289154,
-0.04622366279363632,
0.02893250435590744,
-0.03348880633711815,
0.012096976861357689,
-0.011140153743326664,
-0.018544141203165054,
-0.04993704706430435,
-0.00616239570081234,
0.027884555980563164,
-0.038865238428115845,
-0.011430617421865463,
0.04779558628797531,
-0.015092743560671806,
-0.035493578761816025,
-0.05335427448153496,
-0.01333856862038374,
-0.04023212939500809,
-0.024581238627433777,
0.0497547946870327,
0.0038272920064628124,
-0.039252523332834244,
0.005618487484753132,
0.032896485179662704,
-0.0176100991666317,
-0.022177791222929955,
-0.048934660851955414,
0.020605867728590965,
0.017040561884641647,
0.050119299441576004,
0.00012859089474659413,
-0.036951594054698944,
0.011402140371501446,
-0.019546527415513992,
0.029593167826533318,
-0.02046917751431465,
-0.01145909447222948,
0.040049877017736435,
-0.004670207388699055,
-0.021072886884212494,
0.0020944741554558277,
0.02954760566353798,
-0.053946591913700104,
0.004260140471160412,
0.0034855694975703955,
0.03888802230358124,
0.043148159980773926,
-0.016288772225379944,
-0.027109984308481216,
0.021722160279750824,
0.0008443393744528294,
-0.01249565277248621,
0.006407296750694513,
0.012040022760629654,
0.008480413816869259,
-0.0072729941457509995,
0.0007482299115508795,
0.01035419199615717,
-0.017746789380908012,
-0.044492270797491074,
-0.014249828644096851,
0.05959640443325043,
-0.028385749086737633,
-0.017313940450549126,
0.019854078069329262,
0.04346710070967674,
0.014671285636723042,
0.020002156496047974,
-0.0170291718095541,
-0.008184254169464111,
0.009448627009987831,
-0.02594812773168087,
0.01633433625102043,
0.05718156695365906,
-0.012951282784342766,
0.004624644760042429,
0.0045847767032682896,
-0.040664978325366974,
-0.04107504338026047,
-0.00837789662182331,
0.005923190154135227,
-0.008941738866269588,
0.009368891827762127,
-0.019956594333052635,
-0.005800739396363497,
-0.01905672438442707,
-0.014511815272271633,
0.04501624405384064,
0.029091976583003998,
0.019797123968601227,
0.02972985804080963,
0.008019087836146355,
0.0014850690495222807,
0.016926653683185577,
-0.04620088264346123,
-0.00015644483210053295,
-0.00880504958331585,
0.02059447579085827,
0.0012579659232869744,
-0.012655123136937618,
0.0015548373339697719,
-0.02843131124973297,
-0.014694067649543285,
-0.0048125917091965675,
-0.01092372927814722,
-0.006247826386243105,
0.018339106813073158,
-0.024672364816069603,
-0.01694943569600582,
-0.008486108854413033,
0.006338952574878931,
-0.025264684110879898,
-0.030481647700071335,
-0.016630494967103004,
-0.011721082031726837,
0.028773033991456032,
0.022439777851104736,
-0.02870468981564045,
0.007785577792674303,
0.0013647542800754309,
0.019967984408140182,
-0.027201110497117043,
0.027178330346941948,
0.01035419199615717,
-0.001976295141503215,
-0.019535135477781296,
0.000058778048696694896,
0.0034855694975703955,
-0.012199493125081062,
0.0267910435795784,
0.009289156645536423,
0.006247826386243105,
-0.027223892509937286,
0.01561671867966652,
-0.02471792697906494,
0.0017997385002672672,
-0.004157623741775751,
0.007028092630207539,
0.003052721032872796,
-0.03467344492673874,
0.02246255986392498,
0.009767567738890648,
0.029479261487722397,
0.017051951959729195,
0.009801740758121014,
-0.027907337993383408,
-0.0020104674622416496,
-0.040664978325366974,
-0.028249060735106468,
-0.02567475102841854,
-0.001530632027424872,
0.005410606507211924,
0.012461480684578419,
0.026472102850675583,
0.005564381368458271,
0.03451397269964218,
-0.03310152143239975,
-0.018885863944888115,
-0.0017612947849556804,
0.002859078347682953,
0.0038130534812808037,
0.027087204158306122,
0.014887710101902485,
-0.02161964401602745,
0.00609405105933547,
-0.005570076871663332,
-0.024125609546899796,
-0.023442164063453674,
-0.018418842926621437,
-0.026472102850675583,
0.011880552396178246,
-0.04374048113822937,
-0.007113523315638304,
0.015183869749307632,
0.01645963452756405,
0.011476180516183376,
0.02537859044969082,
0.024444550275802612,
0.015240823850035667,
-0.035265762358903885,
0.024011701345443726,
-0.02051474153995514,
-0.002898945938795805,
0.0092777656391263,
0.0002872604818549007,
0.032395292073488235,
-0.013691681437194347,
0.03084615059196949,
0.01458016037940979,
0.004675902891904116,
-0.014443471096456051,
-0.018771955743432045,
-0.010855385102331638,
-0.026426540687680244,
-0.02155129984021187,
0.00730147073045373,
0.020640039816498756,
-0.001166839967481792,
-0.010433927178382874,
0.035379670560359955,
0.0007902332581579685,
0.0104282321408391,
-0.033124301582574844,
-0.04492511972784996,
0.016049567610025406,
-0.0006884284666739404,
0.04321650415658951,
0.0006934119155630469,
-0.009699223563075066,
0.021824676543474197,
0.012825984507799149,
-0.014284000732004642,
0.0036592783872038126,
-0.0010237436508759856,
-0.008298161439597607,
0.0025842764880508184,
0.009135381318628788,
-0.029342571273446083,
-0.021403219550848007,
0.011983068659901619,
0.015787579119205475,
0.0006823771400377154,
-0.005641269031912088,
-0.002080235630273819,
0.028909724205732346,
0.005524513777345419,
-0.006663588806986809,
-0.056498121470212936,
0.03720219060778618,
0.0011981645366176963,
-0.004943585488945246,
-0.018156856298446655,
0.04572246968746185,
0.04733995720744133,
-0.045563001185655594,
-0.00764319347217679,
-0.043603792786598206,
-0.0022226201836019754,
0.041576236486434937,
-0.006025706883519888,
0.022838454693555832,
0.03260032832622528,
-0.005285308230668306,
0.026950513944029808,
-0.014033404178917408,
-0.025082431733608246,
0.008543062955141068,
0.0033004698343575,
-0.004875240847468376,
-0.0004648850008379668,
-0.004633187782019377,
-0.005985839292407036,
0.026836607605218887,
0.0172228142619133,
-0.002393481321632862,
0.01623181812465191,
-0.002075964119285345,
0.011624260805547237,
0.01316770724952221,
-0.00730147073045373,
-0.003254906740039587,
0.014147311449050903,
-0.007871008478105068,
-0.0018011623760685325,
-0.029456479474902153,
0.0012743402039632201,
-0.007574848830699921,
0.007347033824771643,
-0.0107186958193779,
-0.0022781500592827797,
-0.011066113598644733,
0.003864311845973134,
-0.01779235154390335,
0.016140691936016083,
-0.0049065654166042805,
0.0158787053078413,
0.010547834448516369,
0.012712077237665653,
-0.02387501299381256,
-0.04353544861078262,
-0.015263604931533337,
-0.008651274256408215,
-0.04080166667699814,
-0.007062265183776617,
-0.013965060003101826,
-0.0336710587143898,
-0.008383591659367085,
-0.006287693977355957,
-0.01814546436071396,
0.012119757942855358,
0.02108427882194519,
0.025765877217054367,
0.033238209784030914,
-0.000765316013712436,
-0.04087001085281372,
0.01821380853652954,
0.0017370893619954586,
-0.03150681406259537,
-0.03084615059196949,
0.0017100363038480282,
0.007278689183294773,
-0.035607483237981796,
-0.0397992804646492,
0.029297009110450745,
0.005228354129940271,
0.02633541449904442,
0.0032435159664601088,
0.038181792944669724,
-0.0065382905304431915,
-0.006002925336360931,
0.01446625217795372,
-0.027952900156378746,
-0.008019087836146355,
-0.005732394754886627,
-0.012062804773449898,
-0.009061342105269432,
0.003160933032631874,
-0.02307765930891037,
-0.015525592491030693,
-0.03191688284277916,
-0.03708828240633011,
-0.04683876410126686,
0.025241902098059654,
0.012119757942855358,
-0.01844162493944168,
0.01463711354881525,
0.015320559032261372,
-0.03797676041722298,
0.023351037874817848,
0.01748480089008808,
0.001848149229772389,
0.024467330425977707,
0.02966151386499405,
-0.024239515885710716,
-0.030071580782532692,
-0.0021927193738520145,
0.025401372462511063,
-0.036837685853242874,
-0.030026016756892204,
-0.021255139261484146,
-0.03608589619398117,
-0.02644932083785534,
0.0168355293571949,
0.01333856862038374,
-0.012814593501389027,
-0.016163473948836327,
-0.0011483300477266312,
-0.011544525623321533,
0.0074894181452691555,
-0.027884555980563164,
0.01283737551420927,
0.008674056269228458,
-0.006880013272166252,
-0.0034172250889241695,
0.03244085609912872,
-0.0029502043034881353,
-0.00723312608897686,
0.01852135919034481,
-0.012085585854947567,
0.014910492114722729,
-0.0058092824183404446,
-0.03355715051293373,
-0.01215393003076315,
-0.03364827483892441,
-0.025697533041238785,
0.01038836408406496,
0.041507892310619354,
0.01075286790728569,
-0.00924359355121851,
-0.014170093461871147,
0.02537859044969082,
0.028385749086737633,
-0.01879473775625229,
-0.02437620423734188,
0.011675518937408924,
0.03403555974364281,
0.0013540753861889243,
0.01737089455127716,
0.02740614488720894,
-0.00437120022252202,
0.0025743094738572836,
-0.018088510259985924,
-0.020981762558221817,
-0.05923189967870712,
-0.0027337800711393356,
0.08055538684129715,
-0.0355847030878067,
0.017268376424908638,
-0.02100454270839691,
0.004661664366722107,
-0.0034513971768319607,
0.02590256556868553,
0.012962673790752888,
-0.016562150791287422,
0.007779882289469242,
0.03786285221576691,
-0.002001924440264702,
0.03986762464046478,
0.03957146406173706,
0.020788118243217468,
-0.00008560860442230478,
-0.020423615351319313,
0.04020934924483299,
0.03433172032237053,
-0.03829570114612579,
-0.03219025954604149,
0.003206496126949787,
0.011504657566547394,
0.021448781713843346,
-0.02292957901954651,
0.0017555993981659412,
-0.03510629013180733,
-0.013099362142384052,
-0.009129686281085014,
0.0011355153983458877,
0.015400294214487076,
0.020924808457493782,
0.026426540687680244,
-0.04481121152639389,
-0.0035254370886832476,
-0.001486492925323546,
0.006891403812915087,
0.016049567610025406,
0.02341938205063343,
0.0026939124800264835,
0.021949974820017815,
0.011647041887044907,
0.029684294015169144,
-0.0013611946487799287,
-0.0025202033575624228,
-0.0021827525924891233,
-0.002399176824837923,
0.024581238627433777,
-0.011362273246049881,
-0.022303089499473572,
0.018885863944888115,
-0.01748480089008808,
0.0104282321408391,
0.011743863113224506,
-0.0057266997173428535,
-0.04330763220787048,
-0.01370307244360447,
-0.03581251949071884,
0.026973295956850052,
-0.007922266609966755,
-0.02054891362786293,
0.02763395942747593,
0.006395906209945679,
-0.013919496908783913,
-0.003106827149167657
] | 2024-07-13 | 152 | 39001421 | [
"leukemic cells",
"the immune system",
"The potential",
"the"
] | [
"NK cells",
"T lymphocytes",
"acute myeloid leukemia",
"bioengineering",
"bispecific antibodies",
"chimeric antigen receptor cells",
"dual-affinity retargeting antibodies",
"immune checkpoint inhibitors",
"immune escape",
"immunotherapy"
] | 0 | 10.3390/cancers16132359
10.1002/ajh.25975
10.1002/ajh.26822
10.1038/s41375-022-01613-1
10.1182/blood.2022015850
10.1182/blood.2022016867
10.1056/NEJMoa2012971
10.1200/JCO.20.03736
10.1200/JCO.2011.40.5977
10.1182/blood-2015-07-604546
10.7326/0003-4819-120-8-199404150-00004
10.1111/bjh.16185
10.1038/s41409-021-01515-3
10.1001/jamaoncol.2020.4600
10.1200/JCO.19.03011
10.1056/NEJMoa1609783
10.1200/JCO.22.01725
10.1056/NEJMoa2206913
10.1056/NEJMoa1709866
10.1056/NEJMoa1707447
10.1016/S0140-6736(21)01222-8
10.1056/NEJMoa1411087
10.1182/blood.2019000324
10.1182/blood-2023-185093
10.1038/s41586-020-2864-x
10.1182/blood-2013-08-523548
10.1016/S1470-2045(14)70281-5
10.1038/s41375-018-0180-3
10.1182/bloodadvances.2018017517
10.1056/NEJMoa1815105
10.1016/j.blre.2018.10.003
10.1089/scd.2016.0310
10.1016/S0145-2126(01)00182-5
10.1038/s41375-020-0978-7
10.3324/haematol.2020.262147
10.1158/1535-7163.MCT-19-1093
10.1056/NEJMoa1614359
10.1016/S0140-6736(23)00464-6
10.1056/NEJMoa1902688
10.1182/blood-2012-09-458935
10.1084/jem.20180147
10.3390/ijms22179159
10.1056/NEJMoa2117344
10.1002/(SICI)1097-0215(19970926)73:1<50::AID-IJC9>3.0.CO;2-0
10.1111/jcmm.13662
10.1182/blood-2013-04-493361
10.1182/blood.2019002779
10.1016/j.stem.2010.11.014
10.1182/blood-2023-187450
10.1182/blood-2017-06-791202
10.3324/haematol.2009.014704
10.1182/bloodadvances.2021004424
10.1080/13543784.2018.1452911
10.1182/blood-2023-180876
10.1097/01.HS9.0000969100.45170.e9
10.1200/JCO.2023.41.16_suppl.7045
10.1182/blood-2023-187642
10.1038/s41573-019-0028-1
10.1200/JCO.2020.38.15_suppl.7508
10.1182/blood-2019-127977
10.1182/blood-2019-129042
10.1182/blood.2020007732
10.1111/cts.13467
10.1182/blood-2018-99-119786
10.1016/j.ccell.2017.09.004
10.1172/jci.insight.120974
10.1002/cncr.31896
10.1158/2159-8290.CD-18-1314
10.1126/scitranslmed.aaz0463
10.1182/bloodadvances.2020002512
10.1200/JCO.2023.41.16_suppl.7005
10.1200/JCO.2023.41.16_suppl.7005
10.1038/sj.leu.2404754
10.1080/14712598.2019.1623200
10.1182/blood-2023-187721
10.1097/01.HS9.0000974228.65087.81
10.1182/blood-2023-173302
10.3389/fonc.2022.787108
10.1038/s43018-023-00536-9
10.1158/2159-8290.CD-20-0328
10.1182/blood.2022015956
10.1126/scitranslmed.aav5989
10.1038/s41375-021-01253-x
10.1186/s13045-017-0519-7
10.1126/science.aar6711
10.1136/jitc-2021-003149
10.1002/cam4.5916
10.1016/S2352-3026(22)00378-7
10.1089/hum.2020.216
10.1182/blood-2023-179667
10.1182/blood.V130.Suppl_1.811.811
10.1182/blood-2023-180387
10.1182/blood-2018-99-111326
10.1182/blood-2023-184464
10.1182/blood-2018-99-110579
10.1182/blood-2023-180799
10.1182/blood-2023-180890
10.1182/blood.2020009759
10.1182/blood-2023-177867
10.1038/s41375-023-01905-0
10.1073/pnas.1819992116
10.1016/j.cell.2018.05.013
10.1097/01.HS9.0000972472.24418.bc
10.1186/s13045-020-00996-x
10.1038/onc.2008.267
10.1016/j.molimm.2004.07.034
10.3389/fimmu.2019.01179
10.1016/0167-5699(90)90097-S
10.1182/blood.V94.1.333.413a31_333_339
10.1126/science.1068440
10.1182/blood-2006-07-038687
10.1182/blood-2010-05-283051
10.1182/blood-2007-01-065383
10.1016/j.jaci.2013.07.006
10.1182/blood-2015-12-629055
10.3389/fimmu.2020.00167
10.1038/leu.2012.87
10.1182/blood.V99.10.3661
10.1182/blood-2005-08-027979
10.1016/j.arcmed.2016.02.001
10.3324/haematol.2013.087536
10.1182/blood-2004-07-2585
10.1038/sj.leu.2403524
10.1038/bmt.2012.162
10.1182/blood-2017-05-785659
10.1016/j.bbmt.2016.08.008
10.1016/j.bbmt.2016.04.009
10.1002/pbc.25555
10.1182/blood-2004-07-2974
10.1182/blood-2011-01-329508
10.1158/1078-0432.CCR-17-3196
10.1200/JCO.2009.24.4590
10.1158/1078-0432.CCR-15-1604
10.1016/j.bbmt.2015.12.028
10.1186/s40425-019-0564-6
10.3109/10428194.2014.956316
10.3324/haematol.2012.066613
10.1200/JCO.2005.09.133
10.1097/01.HS9.0000968996.69938.df
10.1182/blood-2023-187722
10.1182/blood-2023-173582
10.1097/01.HS9.0000972304.71265.f8
10.1097/01.HS9.0000972360.43460.10
10.1182/blood.V130.Suppl_1.889.889
10.1200/JCO.2017.35.15_suppl.e18505
10.1186/s40425-019-0761-3
10.1016/j.bbmt.2010.01.019
10.3324/haematol.2015.135301
10.1089/hum.2018.247
10.1158/1078-0432.CCR-16-2981
10.1097/01.HS9.0000967428.42997.44
10.1182/blood-2023-184923
10.1182/blood-2023-178868
10.1182/blood-2023-184986
10.1016/j.jcyt.2017.07.008
10.3390/ijms19041073
10.1182/blood-2023-187192
10.1038/bmt.2017.78
10.1016/j.bbmt.2018.08.028
10.1158/2159-8290.CD-18-0774
10.1182/blood-2019-131494
10.1038/leu.2013.355
10.18632/oncotarget.3324
10.1038/s41375-018-0070-8
10.1182/blood-2019-127345
10.1016/S2352-3026(19)30114-0
10.1056/NEJMoa1601202
10.1182/blood-2008-07-168468
10.1016/j.bbmt.2010.08.005
10.2217/imt-2020-0277
10.1038/s41375-023-01980-3
10.1097/01.HS9.0000972436.95344.a6
10.3390/ijms20092057
10.1182/blood.2023019962
10.1182/blood.2022017795
10.1016/j.ccell.2022.09.007
10.1182/blood.2022016082
10.1038/s41591-019-0400-z
10.1038/s41467-019-08871-1
10.1182/blood-2004-01-0064
10.1182/blood-2023-184727
10.21147/j.issn.1000-9604.2017.05.11
10.1182/blood.2020010344
10.1182/blood-2016-04-708214
10.1182/blood-2023-187626
10.1182/blood-2023-182104
10.1186/s13045-021-01208-w
10.1016/j.stem.2022.10.001
10.1158/1078-0432.CCR-21-3594
10.1182/blood-2023-178675
10.1038/s41590-017-0022-x
10.3390/genes14040873
10.3389/fonc.2021.624742
10.1172/JCI159579
10.1182/blood-2023-173798 | [
"Mosna"
] | [
"Hematology and Bone Marrow Transplantation Unit (BMTU), Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of Paracelsus Medical University (PMU), 39100 Bolzano, Italy."
] | [
"39001421",
"32833263",
"36594187",
"35732831",
"35767897",
"35797463",
"32786187",
"34043428",
"23439754",
"26660427",
"8135448",
"31612473",
"34750562",
"33030517",
"31860405",
"28249141",
"36548927",
"36507690",
"29385370",
"29226797",
"34097852",
"25482239",
"31409671",
"33116311",
"24300852",
"25008258",
"29946192",
"29661755",
"31018069",
"30401586",
"28810819",
"12008077",
"32678289",
"33256372",
"32518207",
"28644114",
"37116523",
"31665578",
"23479569",
"29773641",
"34502069",
"35443108",
"9334809",
"29761849",
"24016461",
"31951650",
"21112565",
"28860210",
"23691459",
"20081055",
"33938941",
"29534618",
"31175342",
"32929488",
"36564917",
"29017060",
"30385732",
"30500073",
"30630850",
"32493790",
"33057635",
"17525725",
"31286786",
"35356211",
"36997747",
"32847940",
"35878001",
"31189721",
"33953290",
"28851445",
"29567707",
"34531250",
"37031462",
"36764323",
"33554732",
"33624009",
"37106163",
"31138698",
"29856956",
"33287858",
"18836474",
"15607806",
"31231370",
"2201309",
"10381530",
"11896281",
"17371948",
"20581313",
"17317850",
"23906377",
"27207791",
"32117298",
"22446501",
"11986221",
"16940427",
"26876298",
"24488563",
"15657183",
"15457184",
"22941380",
"28835441",
"27530969",
"27090958",
"25925135",
"15632206",
"21791425",
"29444931",
"20085940",
"26787753",
"26772158",
"30894213",
"25248882",
"22801961",
"15961759",
"31623687",
"20139023",
"26721894",
"30734584",
"28280089",
"28864289",
"29617289",
"28581465",
"30195074",
"30409776",
"24270737",
"25823822",
"29487386",
"31400961",
"27410923",
"18974373",
"20713164",
"33955237",
"37507426",
"31027331",
"38728431",
"36563336",
"36179686",
"35853161",
"30911134",
"30911002",
"15191948",
"29142466",
"34788382",
"27282944",
"0",
"34789315",
"36332569",
"35349670",
"29348500",
"37107631",
"33718188",
"36099049"
] | [] | 7.049747 | 6.770362 |
39000348 | 731 | UniCAR T-Cell Potency-A Matter of Affinity between Adaptor Molecules and Adaptor CAR T-Cells? | Although Chimeric Antigen Receptor (CAR) T-cells have shown high efficacy in hematologic malignancies, they can cause severe to life-threatening side effects. To address these safety concerns, we have developed adaptor CAR platforms, like the UniCAR system. The redirection of UniCAR T-cells to target cells relies on a Target Module (TM), containing the E5B9 epitope and a tumor-specific binding moiety. Appropriate UniCAR-T activation thus involves two interactions: between the TM and the CAR T-cell, and the TM and the target cell. Here, we investigate if and how alterations of the amino acid sequence of the E5B9 UniCAR epitope impact the interaction between TMs and the UniCAR. We identify the new epitope E5B9L, for which the monoclonal antibody 5B9 has the greatest affinity. We then integrate the E5B9L peptide in previously established TMs directed to Fibroblast Activation Protein (FAP) and assess if such changes in the UniCAR epitope of the TMs affect UniCAR T-cell potency. Binding properties of the newly generated anti-FAP-E5B9L TMs to UniCAR and their ability to redirect UniCAR T-cells were compared side-by-side with the ones of anti-FAP-E5B9 TMs. Despite a substantial variation in the affinity of the different TMs to the UniCAR, no significant differences were observed in the cytotoxic and cytokine-release profiles of the redirected T-cells. Overall, our work indicates that increasing affinity of the UniCAR to the TM does not play a crucial role in such adaptor CAR system, as it does not significantly impact the potency of the UniCAR T-cells. | [
0.031194008886814117,
-0.013997640460729599,
0.0312195997685194,
0.06428166478872299,
-0.048390381038188934,
-0.015788929536938667,
-0.015392285771667957,
0.004289496224373579,
0.01124673243612051,
-0.01972976326942444,
-0.014509436674416065,
-0.05307332053780556,
-0.06131324544548988,
0.01996007189154625,
-0.009372277185320854,
-0.04030399024486542,
0.04723883792757988,
-0.02648548036813736,
-0.0070883845910429955,
0.012532621622085571,
0.04690616950392723,
0.0006565392250195146,
0.008534209802746773,
0.04311887174844742,
-0.01897486299276352,
-0.025704989209771156,
0.02968421019613743,
0.012321505695581436,
-0.007280308287590742,
-0.015302721410989761,
0.06223447993397713,
-0.02991451881825924,
-0.019051631912589073,
0.005185140296816826,
-0.0596243180334568,
0.05578584223985672,
0.01869337446987629,
-0.015046823769807816,
-0.01788729429244995,
-0.0539945550262928,
0.035902541130781174,
0.044347185641527176,
0.014189563691616058,
0.030579853802919388,
-0.09314700216054916,
0.002901247702538967,
-0.022928493097424507,
0.010696551762521267,
-0.0017257145373150706,
0.0217385645955801,
-0.006211932748556137,
-0.013600997626781464,
-0.036465514451265335,
0.020446278154850006,
-0.0462152436375618,
0.026639018207788467,
-0.018245553597807884,
0.03352268412709236,
-0.006483824457973242,
0.015571415424346924,
-0.01920517161488533,
-0.010581397451460361,
-0.014458256773650646,
-0.03449510037899017,
-0.04874863848090172,
-0.0034354354720562696,
-0.050309617072343826,
-0.011937658302485943,
-0.026894917711615562,
0.02497567981481552,
0.009781714528799057,
-0.028097638860344887,
0.026280760765075684,
0.007145961746573448,
0.017260344699025154,
0.0006597379688173532,
-0.007337885443121195,
0.04375861957669258,
-0.014573411084711552,
-0.014151179231703281,
0.04892776533961296,
0.012359891086816788,
0.00033246795646846294,
-0.07052558660507202,
-0.0025957690086215734,
-0.01042146049439907,
0.004030399024486542,
-0.05100054293870926,
-0.03559546172618866,
0.025743374601006508,
0.01164977252483368,
0.017964065074920654,
-0.06489582359790802,
0.03203847259283066,
-0.003995213191956282,
0.04196733236312866,
-0.043733030557632446,
-0.06453756242990494,
0.03656787425279617,
0.03216642513871193,
0.04544754698872566,
-0.006544600706547499,
-0.041532304137945175,
-0.013165970332920551,
0.05023284628987312,
-0.0022167195565998554,
-0.04306769371032715,
-0.023542648181319237,
-0.010882077738642693,
-0.018936477601528168,
0.07078148424625397,
-0.006563792936503887,
-0.031910523772239685,
0.09237930923700333,
0.009762522764503956,
-0.04831361025571823,
-0.02727876417338848,
0.03441832959651947,
0.004734119400382042,
0.0013186761643737555,
-0.014765335246920586,
0.020906895399093628,
0.049234844744205475,
-0.01957622356712818,
0.027713792398571968,
-0.0027972888201475143,
0.09370997548103333,
0.0217385645955801,
-0.05655353516340256,
-0.051026131957769394,
0.05793538689613342,
0.006509414408355951,
0.015571415424346924,
0.017593011260032654,
-0.03380417451262474,
0.028302358463406563,
-0.019243557006120682,
-0.015955261886119843,
-0.049286022782325745,
0.024783756583929062,
0.03907568007707596,
-0.030400725081562996,
0.007606578525155783,
-0.020574228838086128,
-0.02066379226744175,
-0.02235272154211998,
-0.021290743723511696,
0.05394337326288223,
0.01770816557109356,
0.028993284329771996,
-0.03549310192465782,
0.027125226333737373,
0.03237114101648331,
-0.025333937257528305,
-0.013319509103894234,
-0.0776907429099083,
-0.023913701996207237,
0.030068056657910347,
-0.008604582399129868,
-0.04470544308423996,
-0.02676696889102459,
0.026280760765075684,
-0.047878582030534744,
-0.014995643869042397,
0.026024863123893738,
0.022608619183301926,
-0.011381079442799091,
-0.007753720041364431,
-0.09340289980173111,
-0.017196370288729668,
-0.038947731256484985,
-0.03981778398156166,
-0.07272631675004959,
-0.01747785694897175,
-0.04427041485905647,
0.0047661070711910725,
-0.0060551948845386505,
0.00976892001926899,
-0.021636206656694412,
-0.007792104966938496,
0.028916513547301292,
0.017260344699025154,
0.02924918197095394,
-0.012897277250885963,
-0.020075226202607155,
-0.005329083185642958,
-0.01916678622364998,
0.05901016294956207,
-0.04514047130942345,
-0.04194173961877823,
0.025513065978884697,
0.04816007241606712,
0.07543883472681046,
0.013818511739373207,
-0.008419055491685867,
-0.012948457151651382,
0.04859509691596031,
0.01347304880619049,
-0.0054282438941299915,
-0.014061614871025085,
0.036132849752902985,
-0.018667785450816154,
0.003681737696751952,
0.02483493648469448,
-0.03390653058886528,
-0.014803719706833363,
-0.018322322517633438,
0.019141197204589844,
-0.028711795806884766,
0.023171596229076385,
0.06223447993397713,
-0.005050793755799532,
-0.007075589615851641,
0.030912522226572037,
-0.03746351972222328,
-0.004929242189973593,
-0.020599817857146263,
0.014790925197303295,
0.024438293650746346,
0.040687840431928635,
0.0020104015711694956,
-0.002886853413656354,
0.03375299274921417,
-0.002507803961634636,
-0.07564355432987213,
0.0008780512143857777,
-0.02136751264333725,
-0.03823121637105942,
-0.03907568007707596,
0.0025605829432606697,
0.008950045332312584,
0.008866878226399422,
0.027816152200102806,
-0.03065662272274494,
-0.0546598881483078,
0.015520235523581505,
0.016185570508241653,
-0.04365625977516174,
0.046931758522987366,
0.005546596832573414,
-0.014982848428189754,
0.020459074527025223,
0.04595934599637985,
-0.02550027146935463,
-0.006672549527138472,
-0.004538997076451778,
-0.011796914041042328,
-0.031117239966988564,
0.007165153976529837,
0.03352268412709236,
0.022339927032589912,
0.0007880869670771062,
0.025999272242188454,
-0.005968829151242971,
0.0142023591324687,
0.04437277466058731,
0.02230154164135456,
-0.012500634416937828,
0.033829763531684875,
-0.014036024920642376,
0.021303538233041763,
0.054301630705595016,
-0.035390742123126984,
-0.005242717452347279,
-0.033880941569805145,
0.0030739789362996817,
-0.00681969104334712,
0.013792921788990498,
0.008329491131007671,
0.011438656598329544,
0.05926606059074402,
0.01293566171079874,
0.011099590919911861,
-0.008790108375251293,
-0.05425045266747475,
0.030503084883093834,
-0.0026549454778432846,
0.05583702027797699,
0.018680579960346222,
-0.009845688939094543,
-0.01827114261686802,
0.0287373848259449,
0.011240335181355476,
-0.007363475393503904,
-0.01369056198745966,
-0.03915244713425636,
0.0040495917201042175,
0.01012078020721674,
0.002235911786556244,
-0.000548182288184762,
0.0203311238437891,
-0.052280034869909286,
-0.01605762168765068,
-0.015481851063668728,
-0.0067493193782866,
0.009404264390468597,
-0.015046823769807816,
-0.0149060795083642,
-0.04885099455714226,
0.004977222997695208,
-0.03267822042107582,
-0.022570235654711723,
-0.011694555170834064,
-0.03226878121495247,
0.02282613329589367,
0.011381079442799091,
0.023325135931372643,
-0.019947277382016182,
0.00906519964337349,
0.0420696884393692,
0.02061261236667633,
-0.0020279944874346256,
-0.007075589615851641,
0.0009708143770694733,
0.0005917649250477552,
-0.014688565395772457,
0.05020725727081299,
-0.0631045326590538,
0.026408709585666656,
-0.00847663264721632,
-0.022787747904658318,
0.003377858316525817,
-0.049004536122083664,
-0.00403999537229538,
0.037821777164936066,
-0.033036477863788605,
-0.014918874017894268,
-0.002160741714760661,
0.030886931344866753,
0.02141869254410267,
0.015187567099928856,
-0.029888927936553955,
0.024898910894989967,
-0.04076460748910904,
0.009653765708208084,
-0.004091174807399511,
-0.02930036187171936,
-0.02896769344806671,
0.032243192195892334,
0.0441424660384655,
-0.004321483429521322,
-0.002475816523656249,
-0.02479655109345913,
0.030861342325806618,
-0.013383484445512295,
-0.01326833013445139,
0.010875680483877659,
0.0037329173646867275,
0.02676696889102459,
0.005882463417947292,
0.003873661393299699,
0.013255534693598747,
-0.004596574231982231,
0.010063203051686287,
-0.0273299440741539,
0.023875316604971886,
-0.01747785694897175,
-0.013575407676398754,
0.010792513377964497,
-0.00416794465854764,
0.025948094204068184,
-0.001569776446558535,
-0.022698184475302696,
0.027688201516866684,
0.0414043553173542,
0.04342595115303993,
-0.021303538233041763,
0.05409691110253334,
-0.01092046219855547,
-0.05128202959895134,
-0.02694609761238098,
-0.015622594393789768,
0.025807349011301994,
0.03257586061954498,
-0.041301995515823364,
0.024540651589632034,
0.005706533323973417,
-0.003320281160995364,
0.025935297831892967,
-0.014573411084711552,
0.05819128826260567,
-0.013780126348137856,
-0.00958339311182499,
0.0037009299267083406,
-0.0009276315686292946,
0.003540993435308337,
0.02239110693335533,
0.0025493872817605734,
-0.060647912323474884,
0.020305534824728966,
0.022647004574537277,
-0.018667785450816154,
-0.011771324090659618,
-0.04470544308423996,
-0.0015050022630020976,
0.0756947323679924,
0.0015185967786237597,
0.05146116018295288,
0.06254155933856964,
0.018616605550050735,
-0.00643264502286911,
0.0025365925393998623,
-0.00044622275163419545,
-0.05135880038142204,
-0.007644963450729847,
-0.00878371112048626,
0.023209981620311737,
0.017874499782919884,
0.018488656729459763,
-0.009564201347529888,
0.003675340209156275,
-0.007113974541425705,
0.03344591706991196,
0.031194008886814117,
0.023030852898955345,
-0.030835751444101334,
-0.043221231549978256,
0.028020869940519333,
-0.010274318978190422,
0.009090789593756199,
0.011253130622208118,
-0.04526842013001442,
-0.0035697820130735636,
-0.0012642978690564632,
-0.015801724046468735,
-0.0645887479186058,
0.0007980830268934369,
0.033087655901908875,
0.0322943739593029,
-0.03441832959651947,
-0.006736524403095245,
0.060647912323474884,
0.0004474222951103002,
-0.015840107575058937,
-0.010427857749164104,
0.02822558954358101,
-0.015366696752607822,
0.048339199274778366,
-0.06750598549842834,
0.026178402826189995,
-0.006247118581086397,
-0.0047597093507647514,
-0.016978856176137924,
-0.0002828876313287765,
0.03748910874128342,
0.014036024920642376,
-0.01582731306552887,
0.0031731396447867155,
-0.008866878226399422,
0.02085571549832821,
-0.05169146880507469,
-0.062388017773628235,
-0.028327947482466698,
0.04194173961877823,
-0.030016876757144928,
-0.01798965409398079,
0.02666460908949375,
-0.029505081474781036,
0.03216642513871193,
0.011739336885511875,
0.06520289927721024,
-0.04521723836660385,
-0.011822503991425037,
-0.003320281160995364,
-0.02709963545203209,
0.04201851040124893,
0.027176406234502792,
-0.01662059873342514,
0.016121596097946167,
-0.0448845736682415,
-0.023657802492380142,
-0.013895280659198761,
0.03211524337530136,
0.02907005324959755,
0.0005961632123216987,
0.020407894626259804,
0.008099183440208435,
0.0006301496759988368,
0.03940834850072861,
-0.002413441427052021,
0.0019336319528520107,
-0.04729001596570015,
-0.011681759729981422,
0.007126769050955772,
-0.001984811620786786,
0.05015607923269272,
0.019883302971720695,
0.0017529038013890386,
-0.028609436005353928,
0.04795535281300545,
0.02541070617735386,
-0.016236750409007072,
0.00833588931709528,
-0.013537023216485977,
-0.0015457860426977277,
-0.03226878121495247,
0.022890107706189156,
-0.054966967552900314,
-0.042197637259960175,
0.005466628819704056,
-0.0017385095125064254,
0.037770599126815796,
0.005079582333564758,
0.007363475393503904,
0.04531959816813469,
0.042095281183719635,
0.027790561318397522,
0.014803719706833363,
-0.021431487053632736,
0.04537077993154526,
-0.03431596979498863,
-0.06223447993397713,
0.029198002070188522,
-0.0001444426306989044,
-0.04061106964945793,
-0.022288747131824493,
-0.04084137827157974,
-0.0008076792000792921,
-0.01016556192189455,
0.003365063341334462,
0.0005253913113847375,
-0.0217001810669899,
0.006922050379216671,
0.028302358463406563,
0.025346731767058372,
-0.019307531416416168,
-0.03812885656952858,
-0.03597930818796158,
-0.062336839735507965,
-0.049004536122083664,
0.04342595115303993,
-0.017247550189495087,
0.02263421006500721,
0.031245188787579536,
-0.03344591706991196,
-0.0038992511108517647,
-0.020356714725494385,
0.029735388234257698,
0.018808528780937195,
-0.037821777164936066,
0.006512613035738468,
-0.04652232304215431,
0.04780181497335434,
-0.02924918197095394,
-0.006685344502329826,
0.004532599821686745,
-0.001677733613178134,
-0.010978039354085922,
0.03738674893975258,
-0.021482666954398155,
0.02756025269627571,
-0.018245553597807884,
-0.00439185556024313,
0.016492649912834167,
0.021636206656694412,
-0.024399908259510994,
-0.005402653943747282,
-0.03690054267644882,
0.0056937383487820625,
-0.014842105098068714,
-0.021393103525042534,
-0.0014690165407955647,
0.0003486615023575723,
-0.025142014026641846,
-0.04201851040124893,
0.02066379226744175,
0.011592195369303226,
0.0029844145756214857,
-0.04375861957669258,
0.014816515147686005,
-0.010926859453320503,
0.008156760595738888,
0.015021233819425106,
-0.00572892464697361,
0.04222323000431061,
0.024924499914050102,
-0.0005889660678803921,
0.02024156041443348,
0.001448224764317274,
0.0019560230430215597,
-0.025628220289945602,
-0.018475862219929695,
-0.005719328299164772,
0.04429600387811661,
-0.022224772721529007,
0.0041327583603560925,
-0.03887096047401428,
-0.016556624323129654,
0.01180970948189497,
0.03559546172618866,
0.0030755784828215837,
-0.029325950890779495,
0.03237114101648331,
0.025282757356762886,
-0.049900177866220474,
0.027969690039753914,
-0.01270535308867693,
0.00439185556024313,
-0.022467875853180885,
0.006602177396416664,
0.026613429188728333,
-0.006314292084425688,
-0.007414654828608036,
-0.046317603439092636,
-0.059573136270046234,
-0.006135162897408009,
0.01775934547185898,
0.002138350624591112,
-0.005290698725730181,
0.00891805812716484,
0.07789546251296997,
0.03833357244729996,
-0.03884537145495415,
0.03183375671505928,
0.02968421019613743,
0.009928856045007706,
-0.0033810569439083338,
-0.006077586207538843,
-0.022378310561180115,
-0.02024156041443348,
-0.010626179166138172,
-0.00018772543990053236,
-0.007817694917321205,
0.02968421019613743,
-0.005748116876929998,
-0.038615062832832336,
0.006167150568217039,
0.010709346272051334,
0.02620399184525013,
-0.00045981735456734896,
-0.010466243140399456,
-0.028379127383232117,
-0.013421868905425072,
0.02384972758591175,
0.015021233819425106,
-0.006378266494721174,
0.014189563691616058,
0.001808881526812911,
-0.02309482730925083,
-0.012315108440816402,
-0.04240235686302185,
0.008905262686312199,
-0.007427449803799391,
-0.0037361159920692444,
-0.001556181930936873,
-0.018846914172172546,
-0.0008716537849977612,
0.022902902215719223,
0.009077994152903557,
-0.010050407610833645,
-0.021098818629980087,
-0.00401440542191267,
0.033829763531684875,
-0.0031779378186911345,
0.027509072795510292,
-0.04918366298079491,
-0.00011965247540501878,
0.013703357428312302,
0.05921487882733345,
0.04301651567220688,
-0.027790561318397522,
0.047315604984760284,
-0.01422794908285141,
-0.0273299440741539,
-0.022902902215719223,
-0.0036337566561996937,
0.028251178562641144,
0.015251542441546917,
0.028327947482466698,
0.005229922477155924,
0.07953321188688278,
-0.012366288341581821,
-0.011867286637425423,
-0.020535843446850777,
0.01305721327662468,
0.012411070056259632,
0.008930852636694908,
-0.030042467638850212,
-0.05634881928563118,
0.0015817717649042606,
0.013306714594364166,
0.024335933849215508,
-0.030400725081562996,
-0.06407694518566132,
0.02648548036813736,
0.010907667689025402,
-0.0049068508669734,
0.01072853896766901,
0.0028020869940519333,
-0.002859664149582386,
-0.0058344826102256775,
0.0175162423402071,
-0.022275952622294426,
0.004769305698573589,
0.016415879130363464,
-0.022480670362710953,
-0.022045644000172615,
0.0055242059752345085,
-0.011899273842573166,
0.0012754934141412377,
0.029044464230537415,
0.017541833221912384,
0.017209164798259735,
-0.018092013895511627,
0.009845688939094543,
-0.046931758522987366,
0.00582488626241684,
-0.003336274763569236,
0.009474636986851692,
0.05752595141530037,
-0.006234323605895042,
0.0043982528150081635,
-0.012782122939825058,
-0.019409891217947006,
-0.0021399499382823706,
0.008086387999355793,
-0.0013810514938086271,
0.025768965482711792,
0.03480217605829239,
0.01737549901008606,
-0.010427857749164104,
0.03334355726838112,
-0.01747785694897175,
0.019755352288484573,
0.01802803948521614,
0.01434310246258974,
-0.014215153641998768,
0.05000253766775131,
-0.005543398205190897,
0.009756124578416348,
-0.03554427996277809,
-0.003099568886682391,
-0.013549817726016045,
0.012270325794816017,
-0.03889654949307442,
0.018770145252346992,
0.0207021776586771,
-0.04178820177912712,
-0.040508709847927094,
-0.022800544276833534,
0.02474537119269371,
-0.007849682122468948,
-0.014944463968276978,
0.031066060066223145,
0.010197549127042294,
0.04654791206121445,
0.026511069387197495,
0.016211161389946938,
-0.0037585070822387934,
-0.02643430046737194,
-0.006915653124451637,
0.010792513377964497,
-0.012948457151651382,
0.019422685727477074,
-0.009756124578416348,
-0.02080453559756279,
0.008591786958277225,
0.023517059162259102,
-0.026792557910084724,
0.023517059162259102,
0.0014066413277760148,
-0.0020215969998389482,
0.0010699749691411853,
0.0047213248908519745,
-0.01013997197151184,
0.006378266494721174,
0.001997606595978141,
0.013229944743216038,
0.017503447830677032,
0.026357531547546387,
-0.016876496374607086,
-0.016543827950954437,
-0.02085571549832821,
-0.015597004443407059,
0.018898094072937965,
0.00009756124927662313,
-0.0349557138979435,
0.023657802492380142,
-0.015213157050311565,
0.01493166945874691,
-0.04084137827157974,
0.019640199840068817,
-0.00331068504601717,
-0.01326833013445139,
0.006359074264764786,
-0.004974024370312691,
0.0061447592452168465,
0.019217966124415398,
-0.01985771209001541,
-0.009442649781703949,
0.004599772859364748,
0.028583846986293793,
-0.046317603439092636,
-0.0020695780403912067,
0.0026997276581823826,
0.045242831110954285,
0.04567785561084747,
-0.10839854180812836,
-0.031680215150117874,
0.01072853896766901,
0.00022611019085161388,
0.004071982577443123,
0.005463429726660252,
0.016044827178120613,
0.005495417397469282,
-0.003870462765917182,
-0.01732431910932064,
-0.0028292762581259012,
-0.01653103344142437,
0.015187567099928856,
-0.01347304880619049,
0.001863259938545525,
-0.01340907346457243,
-0.03198729455471039,
-0.02907005324959755,
-0.012858892790973186,
0.01887250319123268,
-0.0039184438064694405,
0.018386296927928925,
0.007830489426851273,
0.034162431955337524,
0.012794917449355125,
0.02154664136469364,
-0.012103992514312267,
0.003112363861873746,
-0.030042467638850212,
-0.004938838072121143,
-0.016697367653250694,
0.012430262751877308,
-0.02272377349436283,
0.007568194065243006,
-0.007145961746573448,
-0.026894917711615562,
0.021354718133807182,
-0.013089201413094997,
-0.010632576420903206,
0.011259527876973152,
0.019896097481250763,
-0.003969623241573572,
0.019461069256067276,
-0.012046415358781815,
-0.02319718524813652,
-0.016889290884137154,
-0.009474636986851692,
0.017900090664625168,
0.0068132937885820866,
-0.03024718537926674,
0.0033682622015476227,
-0.00971774011850357,
-0.05291977897286415,
0.022429490461945534,
-0.017529036849737167,
-0.028532667085528374,
-0.0038768600206822157,
0.0025189993903040886,
0.022519055753946304,
0.01836070790886879,
-0.005559391807764769,
0.029786568135023117,
0.03751469776034355,
-0.006941243074834347,
0.013370689004659653,
-0.002450226806104183,
-0.030835751444101334,
0.050309617072343826,
-0.03272939845919609,
-0.0014322311617434025,
-0.009756124578416348,
0.004062386229634285,
-0.042197637259960175,
0.01713239587843418,
0.0037585070822387934,
0.02996569685637951,
0.0011219544103369117,
0.014854899607598782,
-0.005584981758147478,
0.035058073699474335,
0.021623410284519196,
-0.007824092172086239,
-0.008630172349512577,
0.0010875680018216372,
-0.02314600721001625,
-0.016262341290712357,
-0.0091099813580513,
0.013332304544746876,
0.006071188487112522,
-0.0203311238437891,
-0.009551405906677246,
-0.004027200397104025,
-0.009212341159582138,
0.007248321082442999,
-0.015788929536938667,
-0.01363938208669424,
-0.011310707777738571,
0.016211161389946938,
-0.013070008717477322,
-0.03283175826072693,
0.04160907119512558,
-0.01704283058643341,
-0.017503447830677032,
-0.03137313947081566,
-0.05020725727081299,
0.01944827474653721,
0.014547822065651417,
-0.014163973741233349,
0.010466243140399456,
-0.003512204857543111,
0.040969327092170715,
0.01836070790886879,
-0.0012658971827477217,
-0.011636978015303612,
0.024246368557214737,
0.023657802492380142,
0.0056937383487820625,
-0.00833588931709528,
0.010658166371285915,
0.008220735006034374,
0.015008438378572464,
0.018347911536693573,
0.006870870944112539,
-0.012692558579146862,
-0.007894464768469334,
0.001619356800802052,
0.00948743149638176,
0.032754991203546524,
0.027355534955859184,
-0.03413683921098709,
0.026024863123893738,
-0.006922050379216671,
-0.02953067049384117,
-0.02544909156858921,
-0.0031651428434997797,
0.030016876757144928,
0.026459889486432076,
0.01901324838399887,
0.0028916513547301292,
0.023542648181319237,
-0.009640970267355442,
-0.02282613329589367,
0.033036477863788605,
-0.014765335246920586,
0.020868511870503426,
0.01911560818552971,
-0.06504936516284943,
0.02709963545203209,
-0.017362702637910843,
0.013869690708816051,
-0.028481487184762955,
0.031117239966988564,
0.02216079831123352,
0.04992577061057091,
-0.0048908572643995285,
0.007229128386825323,
0.02896769344806671,
-0.02996569685637951,
-0.009071596898138523,
0.05000253766775131,
-0.022250361740589142,
0.04514047130942345,
-0.004302291199564934,
-0.014330307953059673,
0.009519418701529503,
-0.0202927403151989,
-0.02015199512243271,
0.006333484314382076,
0.03713085129857063,
0.025858528912067413,
0.031347550451755524,
-0.04908130317926407,
0.07328929007053375,
-0.01952504552900791,
-0.01943548023700714,
0.007280308287590742,
0.029146822169423103,
0.004372663330286741,
0.005792899057269096,
0.018885299563407898,
-0.0483647882938385,
0.00003278697840869427,
0.005370666738599539,
0.026357531547546387,
0.011739336885511875,
-0.008086387999355793,
0.009046006947755814,
-0.03794972598552704,
0.03170580789446831,
-0.004772504325956106,
-0.012698955833911896,
0.008572595193982124,
0.025436297059059143,
0.043272413313388824,
0.037642646580934525,
0.005485821049660444,
-0.03449510037899017,
0.003174738958477974,
-0.042658254504203796,
-0.03592813014984131,
-0.036747004836797714,
0.02141869254410267,
0.020113611593842506,
-0.01878293976187706,
-0.027253175154328346,
-0.0010723740560933948,
0.023401904851198196,
-0.03231996297836304,
0.028020869940519333,
0.0428117960691452,
-0.013524227775633335,
0.05018166825175285,
-0.020497458055615425,
0.007894464768469334,
0.019192377105355263,
-0.02384972758591175,
-0.002296687802299857,
-0.03234555199742317,
-0.038947731256484985,
-0.013805716298520565,
-0.035902541130781174,
-0.016326315701007843,
0.006368670146912336,
0.017951270565390587,
-0.0007700941059738398,
-0.009545008651912212,
0.014854899607598782,
-0.003149149240925908,
-0.0012227143160998821,
0.015174772590398788,
-0.043323591351509094,
0.031629037111997604,
-0.014547822065651417,
0.002133552450686693,
-0.009525815956294537,
0.0028756577521562576,
-0.003793693147599697,
-0.02432313933968544,
-0.001952824299223721,
-0.020817331969738007,
0.037412337958812714,
-0.0062407213263213634,
0.008700544014573097,
-0.022979672998189926,
-0.01340907346457243,
-0.0068132937885820866,
0.028660615906119347,
0.010926859453320503,
-0.0069988202303647995,
-0.03267822042107582,
-0.006128765642642975,
-0.012174364179372787,
0.0207021776586771,
0.012391878291964531,
0.06622649729251862,
-0.003275498980656266,
0.012647775933146477,
0.034827765077352524,
0.0112019507214427,
0.01422794908285141,
0.022647004574537277,
0.0014594203094020486,
-0.021213972941040993,
0.004305489826947451,
0.009321097284555435,
-0.00040783800068311393,
-0.00706919189542532,
0.00627910578623414,
-0.004158348310738802,
0.0012019225396215916,
0.027227584272623062,
0.026229580864310265,
0.007587386295199394,
0.00719714118167758,
0.014560616575181484,
-0.014688565395772457,
0.024924499914050102,
-0.013070008717477322,
-0.009890471585094929,
0.011093193665146828,
0.0010547810234129429,
-0.009992830455303192,
-0.03830798342823982,
0.0002902846899814904,
0.025820143520832062,
0.007062794640660286,
-0.010536614805459976,
0.006627767346799374,
0.0051627494394779205,
-0.0011787317926064134,
-0.004027200397104025,
0.0015481850132346153,
0.01366497203707695,
0.006423048675060272,
0.02309482730925083,
-0.02108602412045002,
0.006704536732286215,
0.0034514290746301413,
0.02883974462747574,
-0.023504264652729034,
0.03075898252427578,
0.022736569866538048,
-0.0002746908867266029,
-0.03638874739408493,
0.029453901574015617,
-0.0012970848474651575,
0.01793847419321537,
-0.02019038051366806,
0.05074464529752731,
-0.0033522683661431074,
-0.016275135800242424,
-0.010479037649929523,
0.023504264652729034,
-0.01948666013777256,
0.016633393242955208,
0.015021233819425106,
-0.017388293519616127,
0.012167966924607754,
0.006653357297182083,
0.04775063320994377,
-0.007875272072851658,
0.0076193735003471375,
0.009653765708208084,
0.01836070790886879,
-0.008745326660573483,
-0.0016969259595498443,
-0.004235117696225643,
-0.017490653321146965,
-0.015699364244937897,
-0.01656941883265972,
0.00576411047950387,
-0.00780489994212985,
0.01369056198745966,
0.026140017434954643,
0.012404672801494598,
-0.0008636569837108254,
0.007894464768469334,
0.020407894626259804,
-0.001808881526812911,
0.010012023150920868,
0.011317105032503605,
0.007836887612938881,
-0.0002952827198896557,
0.013095598667860031,
0.019614608958363533,
0.007900862023234367,
-0.005303493235260248,
-0.02686932682991028,
-0.019589019939303398,
-0.01596805825829506,
0.05906134098768234,
-0.034725405275821686,
-0.006317490711808205,
0.0462152436375618,
-0.029453901574015617,
-0.003110764315351844,
0.008483030833303928,
0.02784174121916294,
-0.0033842558041214943,
0.003489813767373562,
-0.0011899273376911879,
0.004724523518234491,
0.022710978984832764,
-0.009545008651912212,
-0.002120757708325982,
0.024719782173633575,
-0.00885408278554678,
0.004145553335547447,
0.002931635593995452,
0.020599817857146263,
0.0043086884543299675,
0.02427195943892002,
-0.02502685971558094,
0.03833357244729996,
0.027253175154328346,
0.01742667891085148,
0.042095281183719635,
0.005364269483834505,
0.002488611498847604,
0.00873253121972084,
-0.0031603446695953608,
0.0007808898226357996,
-0.013306714594364166,
-0.024476677179336548,
-0.0021991264075040817,
0.006074387114495039,
-0.01605762168765068,
-0.022954082116484642,
0.010664563626050949,
-0.014867694117128849,
-0.018962068483233452,
0.0005133960512466729,
0.018603811040520668,
-0.014061614871025085,
-0.015251542441546917,
-0.019832123070955276,
-0.009276315569877625,
-0.0007880869670771062,
-0.007363475393503904,
-0.023312339559197426,
-0.01770816557109356,
-0.018002448603510857,
0.012276723980903625,
-0.00906519964337349,
0.006464632228016853,
0.005153153091669083,
0.006570190191268921,
0.015840107575058937,
0.010235934518277645,
-0.03109165094792843,
0.016096007078886032,
0.01197604276239872,
-0.04022722318768501,
0.009756124578416348,
-0.0298121590167284,
0.008342286571860313,
0.008265516720712185,
-0.03283175826072693,
-0.00993525329977274,
0.015315516851842403,
-0.006928448099642992,
0.0012467048363760114,
-0.012545417062938213,
-0.02497567981481552,
-0.01319156028330326,
-0.008969237096607685,
0.012846097350120544,
0.014893284067511559,
-0.02286451868712902,
0.025717785581946373,
-0.004686138592660427,
-0.0161088015884161,
0.0073442826978862286,
-0.031577859073877335,
-0.03551869094371796,
0.03293411806225777,
0.0043086884543299675,
0.006471029482781887,
-0.020740561187267303,
-0.007133166771382093,
0.004622164182364941,
-0.014778129756450653,
0.0294027216732502,
0.03656787425279617,
0.016786932945251465,
-0.02367059886455536,
-0.0013010832481086254,
-0.00662137009203434,
0.035953719168901443,
0.020919689908623695,
0.019947277382016182,
0.014944463968276978,
-0.0092955082654953,
-0.030835751444101334,
-0.04744355380535126,
-0.006314292084425688,
-0.007913656532764435,
-0.021495461463928223,
0.020740561187267303,
0.019896097481250763,
-0.02212241291999817,
-0.00021731368906330317,
0.015289926901459694,
0.020113611593842506,
0.008169555105268955,
0.011393873952329159,
0.009250725619494915,
-0.022736569866538048,
-0.0034994101151823997,
0.010235934518277645,
0.004455829970538616,
0.022954082116484642,
0.05537640303373337,
0.02408003620803356,
0.03487894684076309,
-0.010779717937111855,
0.014253538101911545,
0.015443465672433376,
-0.017580216750502586,
0.0031091650016605854,
-0.040969327092170715,
0.004551792051643133,
0.008105580694973469,
-0.0110164238139987,
0.02212241291999817,
0.013626587577164173,
-0.0099992286413908,
-0.013562613166868687,
0.02226315625011921,
0.00964736845344305,
0.0014378288760781288,
-0.02935154177248478,
-0.0001441427448298782,
-0.028532667085528374,
-0.004791696555912495,
0.006170349195599556,
0.007964836433529854,
-0.02301805652678013,
-0.04240235686302185,
-0.004420644138008356,
0.01709401048719883,
-0.016428673639893532,
-0.019742557778954506,
-0.027074046432971954,
0.010005625896155834,
-0.013754536397755146,
-0.03825680539011955,
-0.021188383921980858,
0.011803311295807362,
0.011534618213772774,
-0.011419463902711868,
-0.020024046301841736,
-0.004116764757782221,
0.01775934547185898,
0.03700290247797966,
-0.033829763531684875,
0.013127585873007774,
0.00793284922838211,
0.02437431924045086,
-0.007504219189286232,
-0.011349092237651348,
0.007856079377233982,
-0.011573003605008125,
0.014471052214503288,
-0.027688201516866684,
-0.0413275845348835,
0.004251111298799515,
0.03109165094792843,
-0.0021399499382823706,
0.00850222259759903,
0.0349557138979435,
-0.019499454647302628,
-0.008252722211182117,
-0.013549817726016045,
-0.006400657817721367,
0.06351397186517715,
-0.01788729429244995,
-0.007312295492738485,
-0.009122776798903942,
-0.015891287475824356,
-0.019128402695059776,
0.0005061989650130272,
0.017720961943268776,
-0.004068783950060606,
0.01270535308867693,
0.017733756452798843,
0.0014666174538433552,
-0.020126406103372574,
0.007011615205556154,
0.009896868839859962,
0.030298365280032158,
0.007165153976529837,
0.010792513377964497,
0.0007537006167694926,
-0.0040495917201042175,
-0.016940470784902573,
-0.012308711186051369,
0.0008092785719782114,
-0.04752032458782196,
0.02305644191801548,
0.03554427996277809,
0.041532304137945175,
0.0010044010123237967,
0.01422794908285141,
0.015712158754467964,
0.02047186903655529,
-0.013140380382537842,
-0.019422685727477074,
-0.012551814317703247,
0.00024890113854780793,
0.002327075693756342,
-0.0048460750840604305,
-0.014752540737390518,
0.0015633790753781796,
-0.02047186903655529,
0.018846914172172546,
0.023440290242433548,
0.0009452245431020856,
0.0034802176523953676,
0.021265152841806412,
-0.007081986870616674,
0.010709346272051334,
-0.03249908983707428,
0.028199998661875725,
-0.015801724046468735,
-0.02868620492517948,
-0.024451088160276413,
0.013127585873007774,
-0.013421868905425072,
0.005584981758147478,
-0.045575495809316635,
0.0027221187483519316,
0.02193048968911171,
-0.02404165081679821,
-0.01723475381731987,
0.025768965482711792,
0.016684573143720627,
-0.0041391560807824135,
-0.04112286493182182,
-0.014112794771790504,
-0.014829309657216072,
0.00627910578623414,
0.016326315701007843,
0.009679355658590794,
-0.00493244081735611,
-0.03098929114639759,
0.027509072795510292,
-0.012155172415077686,
-0.011956850998103619,
-0.01883411966264248,
-0.034725405275821686,
0.0189236830919981,
-0.027022866532206535,
-0.018245553597807884,
0.010875680483877659,
0.01258380152285099,
-0.02606324851512909,
0.01200163271278143,
-0.011547413654625416,
0.022531850263476372,
0.023261161521077156,
0.062285661697387695,
-0.0182199627161026,
0.003684936324134469,
-0.003681737696751952,
-0.0001671336212893948,
-0.00926991831511259,
0.00019182381220161915,
0.002012000884860754,
-0.006634165067225695,
0.0036561477463692427,
0.016492649912834167,
0.013306714594364166,
-0.004033597651869059,
-0.0000634747848380357,
-0.008815698325634003,
-0.006614972371608019,
0.010280716232955456,
-0.03188493475317955,
0.006550997961312532,
0.011803311295807362,
0.023657802492380142,
0.014381487853825092,
0.026280760765075684,
-0.04741796478629112,
0.01639029011130333,
-0.0010499829659238458,
-0.016185570508241653,
0.029888927936553955,
-0.006368670146912336,
-0.020587023347616196,
0.037924136966466904,
0.014432667754590511,
0.0036881351843476295,
0.019985660910606384,
-0.0008000822272151709,
0.011956850998103619,
0.03976660594344139,
-0.02038230374455452,
-0.006634165067225695,
0.04544754698872566,
-0.021469872444868088,
-0.008271913975477219,
0.016044827178120613,
0.01952504552900791,
0.007856079377233982,
0.029044464230537415,
0.01630072481930256,
-0.023069236427545547,
0.0006445439648814499,
-0.02822558954358101,
0.014279128052294254,
-0.023312339559197426,
0.013754536397755146,
0.13132703304290771,
0.0068068960681557655,
0.01813039928674698,
-0.0009164359653368592,
0.01422794908285141,
-0.031014880165457726,
0.003608166938647628,
0.02300526201725006,
0.004065585322678089,
0.001980013446882367,
0.0037233210168778896,
0.04076460748910904,
-0.0012075203703716397,
-0.0006333484197966754,
0.022902902215719223,
-0.01586569845676422,
-0.006199137773364782,
0.017784936353564262,
-0.03342032432556152,
-0.0029380330815911293,
-0.0026805351953953505,
-0.004727722145617008,
-0.028148818761110306,
0.03334355726838112,
-0.009007622487843037,
-0.0012610991252586246,
0.009685752913355827,
-0.027764972299337387,
0.009033212438225746,
0.0057833027094602585,
0.035288382321596146,
0.0029076451901346445,
0.02164900116622448,
-0.035237204283475876,
0.009730534628033638,
-0.02845589816570282,
-0.014253538101911545,
-0.005968829151242971,
0.017298728227615356,
-0.025986477732658386,
0.003880058880895376,
0.014240743592381477,
0.01232790295034647,
0.024246368557214737,
0.03459745645523071,
-0.0025317943654954433,
-0.02193048968911171,
-0.0054794237948954105,
-0.0015121994074434042,
-0.0518450066447258,
-0.004791696555912495,
-0.014547822065651417,
0.005431442521512508,
0.0013298718258738518,
-0.02704845555126667,
-0.006192740052938461,
0.02761143259704113,
0.009545008651912212,
-0.01925635151565075,
-0.038615062832832336,
-0.02061261236667633,
0.03372740373015404,
0.03551869094371796,
0.020830126479268074,
0.04007368162274361
] | 2024-07-13 | 71 | 39000348 | [
"UniCAR",
"cells",
"UniCAR T-cell potency",
"such adaptor CAR system",
"UniCAR T-cells",
"TMs",
"adaptor CAR platforms",
"Appropriate UniCAR-T activation",
"anti-FAP-E5B9 TMs",
"increasing affinity",
"TM",
"the E5B9 UniCAR epitope",
"FAP",
"such changes",
"the UniCAR epitope",
"the UniCAR T-cells",
"Fibroblast Activation Protein",
"side",
"hematologic malignancies",
"the UniCAR system",
"high efficacy",
"CAR",
"Binding properties",
"Target Module",
"the CAR T-cell",
"the redirected T-cells",
"E5B9L",
"the target cell",
"the UniCAR",
"life-threatening side effects"
] | [
"E5B9 UniCAR epitope",
"Fibroblast Activation Protein (FAP)",
"UniCAR T-cells",
"adaptor CAR platform",
"cancer immunotherapy"
] | 0 | 10.3390/ijms25137242
10.1073/pnas.86.24.10024
10.1126/science.aar6711
10.1016/j.coi.2016.06.004
10.1038/nbt0102-70
10.3389/fimmu.2023.1321596
10.1056/NEJMoa2308917
10.1038/s41591-022-02017-5
10.1038/s41581-022-00651-3
10.1126/scitranslmed.3002842
10.1126/scitranslmed.3005930
10.1056/NEJMoa1215134
10.1016/S0140-6736(14)61403-3
10.1007/s11912-021-01161-4
10.3389/fimmu.2022.927153
10.1038/mt.2010.24
10.1097/MS9.0000000000001375
10.2174/2589977515666230220092125
10.1007/s11899-023-00687-7
10.1136/jitc-2022-005878
10.1038/bcj.2016.61
10.1016/j.cell.2018.03.038
10.1182/blood.V124.21.3494.3494
10.1038/s41467-020-20671-6
10.1038/s41551-023-01048-8
10.1016/j.imlet.2019.05.003
10.1007/s00262-019-02399-5
10.3390/cancers13194785
10.3390/cancers16010168
10.1038/s41551-023-01102-5
10.1038/s41375-023-01905-0
10.1158/2767-9764.CRC-21-0150
10.1080/2162402X.2022.2140534
10.3390/biomedicines10102420
10.1080/2162402X.2021.2003532
10.1016/j.addr.2022.114358
10.1038/s42003-020-1021-2
10.3389/fonc.2019.00176
10.1038/s41388-022-02416-5
10.1006/jaut.1996.0097
10.1089/dna.1998.17.751
10.1002/1529-0131(200201)46:1<202::AID-ART10062>3.0.CO;2-Y
10.1016/0014-4827(89)90038-4
10.4049/jimmunol.150.7.3091
10.1016/0896-8411(89)90159-5
10.1046/j.1365-2249.1998.00558.x
10.1080/2162402X.2019.1659095
10.1080/2162402X.2017.1287246
10.1186/s13046-023-02912-w
10.1186/s13046-020-01572-4
10.1038/s41434-023-00404-2
10.1016/j.ymthe.2020.10.008
10.3389/fimmu.2018.00507
10.3389/fimmu.2022.1090959
10.1016/j.ymthe.2021.10.011
10.3389/fimmu.2022.902594
10.1126/scitranslmed.aau5907
10.1158/1078-0432.CCR-13-0330
10.1038/s41586-022-05126-w
10.1186/s12967-023-04041-6
10.1016/j.intimp.2023.110873
10.1158/0008-5472.CAN-15-0159
10.3389/fimmu.2022.1032403
10.1080/2162402X.2021.1945804
10.1016/j.jaut.2013.01.002
10.1182/blood.2020009759
10.1111/bph.12106
10.1016/j.it.2019.10.005
10.1016/j.annonc.2020.10.478
10.1038/s41408-021-00459-7
10.3390/biom12091303
10.3389/fimmu.2020.01046 | [
"Boutier",
"Loureiro",
"Hoffmann",
"Arndt",
"Bartsch",
"Feldmann",
"Bachmann"
] | [
"Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden, Germany.",
"Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden, Germany.",
"Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden, Germany.",
"Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden, Germany.\nMildred Scheel Early Career Center, Faculty of Medicine Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.",
"Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden, Germany.",
"Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden, Germany.\nNational Center for Tumor Diseases Dresden (NCT/UCC), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.\nFaculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.\nGerman Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.",
"Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden, Germany.\nNational Center for Tumor Diseases Dresden (NCT/UCC), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.\nFaculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.\nGerman Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany."
] | [
"39000348",
"2513569",
"29567707",
"27372731",
"11753365",
"38090558",
"38381673",
"36109639",
"36323874",
"21832238",
"23515080",
"23527958",
"25319501",
"35059997",
"35757715",
"20179677",
"38098580",
"36825696",
"36763238",
"36593069",
"27518241",
"29706540",
"33514714",
"37291434",
"31091431",
"31542798",
"34638268",
"38201595",
"37798444",
"37106163",
"36874404",
"36387056",
"36289682",
"35686214",
"35618140",
"32518350",
"30984613",
"35859167",
"9115577",
"9778034",
"11817591",
"2530103",
"8454877",
"2476998",
"9566804",
"31646084",
"28507794",
"38102692",
"32370811",
"37173386",
"33129371",
"29619024",
"36700225",
"34678512",
"35572501",
"31270272",
"23620405",
"36002574",
"36922828",
"37690235",
"26330166",
"36325345",
"34290907",
"23352111",
"33624009",
"23330947",
"31734148",
"33098993",
"33824268",
"36139142",
"32636832"
] | [] | 8.427506 | 4.71847 |
39000281 | 732 | CAR-T Cells Therapy in Glioblastoma: A Systematic Review on Molecular Targets and Treatment Strategies. | The most common primary brain tumor is glioblastoma (GBM), yet the current therapeutic options for this disease are not promising. Although immunotherapeutic techniques have shown poor success in GBM thus far despite efforts, new developments provide optimism. One of these developments is chimeric antigen receptor (CAR)-T cell treatment, which includes removing and genetically modifying autologous T cells to produce a receptor that targets a GBM antigen before reintroducing the cells into the patient's body. A number of preclinical studies have produced encouraging results, which have led to the start of clinical trials assessing these CAR-T cell treatments for GBM and other brain tumors. Although results in tumors such as diffuse intrinsic pontine gliomas and lymphomas have been promising, preliminary findings in GBM have not produced any clinical benefits. The paucity of particular antigens in GBM, their inconsistent expression patterns, and the possible immunoediting-induced loss of these antigens after antigen-targeted therapy are some possible causes for this discrepancy. The goal of this systematic literature review is to assess potential approaches for creating CAR-T cells that are more effective for this indication, as well as the clinical experiences that are already being had with CAR-T cell therapy in GBM. Up until 9 May 2024, a thorough search was carried out across the three main medical databases: PubMed, Web of Science, and Scopus. Relevant Medical Subject Heading (MeSH) terms and keywords associated with "glioblastoma", "CAR-T", "T cell therapy", "overall survival", and "progression free survival" were employed in the search approach. Preclinical and clinical research on the application of CAR-T cells as a therapeutic approach for GBM are included in the review. A total of 838 papers were identified. Of these, 379 articles were assessed for eligibility, resulting in 8 articles meeting the inclusion criteria. The included studies were conducted between 2015 and 2023, with a total of 151 patients enrolled. The studies varied in CAR-T cell types. EGFRvIII CAR-T cells were the most frequently investigated, used in three studies (37.5%). Intravenous delivery was the most common method of delivery (62.5%). Median OS ranged from 5.5 to 11.1 months across the studies. PFS was reported in only two studies, with values of 7.5 months and 1.3 months. This systematic review highlights the evolving research on CAR-T cell therapy for GBM, emphasizing its potential despite challenges. Targeting antigens like EGFRvIII and IL13Rα2 shows promise in treating recurrent GBM. However, issues such as antigen escape, tumor heterogeneity, and immunosuppression require further optimization. Innovative delivery methods, combination therapies, and personalized approaches are crucial for enhancing CAR-T cell efficacy. Ongoing research is essential to refine these therapies and improve outcomes for GBM patients. | [
-0.007925230078399181,
0.04503653198480606,
0.06561674922704697,
0.02318735420703888,
-0.06497073918581009,
-0.02510233037173748,
0.013427901081740856,
0.032370008528232574,
-0.01157060544937849,
-0.019357403740286827,
0.012066652998328209,
-0.030455032363533974,
-0.023787226527929306,
0.017880795523524284,
0.010832301340997219,
-0.021526170894503593,
0.04381371662020683,
-0.03834565356373787,
0.019253579899668694,
0.016323436051607132,
0.004623050801455975,
0.022149113938212395,
-0.008248237892985344,
-0.001104571740143001,
-0.03532322496175766,
-0.018549883738160133,
0.00985174160450697,
0.013947021216154099,
-0.03779192641377449,
-0.02196453884243965,
-0.0024831234477460384,
-0.006967742461711168,
-0.02960136905312538,
-0.029278360307216644,
-0.028724633157253265,
0.03460799157619476,
0.03082418441772461,
-0.01620807684957981,
0.0028825572226196527,
0.0009127857629209757,
0.031816281378269196,
0.006817774381488562,
0.015112156048417091,
0.06358641386032104,
-0.05117368325591087,
-0.006194830406457186,
0.01429310068488121,
-0.06981585919857025,
-0.018596027046442032,
-0.008282845839858055,
-0.027224954217672348,
0.015619740821421146,
-0.044505879282951355,
0.047089941799640656,
-0.021791499108076096,
0.0018385496223345399,
-0.04007605463266373,
-0.005687246564775705,
0.011985900811851025,
0.012308909557759762,
-0.0001339257141808048,
0.01068810187280178,
0.0387609526515007,
-0.035461656749248505,
-0.07023115456104279,
-0.009920957498252392,
-0.041137367486953735,
-0.016150396317243576,
0.026348218321800232,
0.005514206830412149,
0.009880581870675087,
-0.025240762159228325,
0.020764796063303947,
0.002941679209470749,
0.031308695673942566,
0.029209144413471222,
0.022368298843503,
0.008530870079994202,
0.0361768864095211,
-0.033385176211595535,
0.00675432663410902,
-0.02948600985109806,
0.007313822396099567,
-0.030731895938515663,
-0.03239307925105095,
0.0008168928325176239,
0.019611194729804993,
-0.021087802946567535,
-0.043882932513952255,
-0.009211493656039238,
-0.03998376801609993,
-0.020038027316331863,
-0.0427754782140255,
0.04182952642440796,
-0.008703909814357758,
-0.015100620687007904,
0.005015274975448847,
-0.046466998755931854,
0.025448409840464592,
0.03193163871765137,
0.01636957935988903,
0.02048793062567711,
-0.02349882572889328,
-0.026717370375990868,
0.06677035242319107,
-0.017961548641324043,
-0.060448624193668365,
-0.024917753413319588,
0.03996069356799126,
-0.021722283214330673,
0.05283486843109131,
0.01026126928627491,
0.008778894320130348,
0.04319077357649803,
-0.02228754758834839,
-0.02830933779478073,
-0.020857082679867744,
-0.032969880849123,
0.0006593543221242726,
0.03262380138039589,
-0.037930358201265335,
0.02560991421341896,
-0.0003129139367956668,
-0.0316317044198513,
0.04076821357011795,
-0.03179320693016052,
0.0749378353357315,
-0.05537278577685356,
0.000515514868311584,
-0.0621098093688488,
0.03407733514904976,
0.002967635402455926,
0.044736597687006,
-0.02616364136338234,
-0.0735996663570404,
-0.019864987581968307,
-0.019830379635095596,
0.013889340683817863,
-0.045521046966314316,
0.022968171164393425,
-0.0027599872555583715,
-0.02114548347890377,
-0.027778681367635727,
0.01300106942653656,
-0.017027132213115692,
-0.0304319616407156,
-0.004980667028576136,
0.03190856799483299,
-0.023279642686247826,
0.041298869997262955,
-0.04132194072008133,
0.027986329048871994,
0.03970690444111824,
-0.023671867325901985,
-0.010220893658697605,
-0.032093144953250885,
-0.020591754466295242,
0.08841188251972198,
-0.04872805252671242,
-0.06916984170675278,
0.0009791178163141012,
0.01993420347571373,
0.006212134379893541,
-0.014673789031803608,
0.03643067926168442,
0.051081396639347076,
-0.02812476083636284,
-0.008455885574221611,
-0.059156592935323715,
0.00022999894281383604,
0.02964751236140728,
-0.04256783053278923,
-0.06797009706497192,
-0.02510233037173748,
-0.05154283717274666,
0.012089725583791733,
0.0077637261711061,
0.014500748366117477,
-0.01695791631937027,
-0.02349882572889328,
-0.014812220819294453,
0.027248024940490723,
0.01883828453719616,
0.02392565831542015,
-0.030893400311470032,
0.03386968746781349,
0.006927366368472576,
0.0011557627003639936,
-0.05878744274377823,
-0.016219612210989,
0.03666139766573906,
-0.03230079263448715,
0.06640119850635529,
0.009592182002961636,
0.009661397896707058,
-0.02662508189678192,
0.04997393861413002,
0.00035779617610387504,
-0.02701730653643608,
0.017753899097442627,
0.02897842600941658,
-0.030293529853224754,
-0.03548472747206688,
-0.01973809115588665,
-0.026740441098809242,
-0.04593634232878685,
0.02773253805935383,
0.04515189304947853,
-0.025702202692627907,
0.0020058215595781803,
0.043490711599588394,
-0.009684469550848007,
-0.007463790476322174,
0.0070023504085838795,
-0.0284708421677351,
-0.026717370375990868,
-0.04379064589738846,
0.040791288018226624,
0.03520786389708519,
0.023879515007138252,
0.02734031341969967,
-0.020038027316331863,
-0.025563770905137062,
0.033938903361558914,
-0.01890750043094158,
0.02498696930706501,
0.022887418046593666,
-0.006460158620029688,
-0.0029560993425548077,
-0.027755608782172203,
0.004845119081437588,
-0.009615253657102585,
0.025955993682146072,
-0.029462937265634537,
-0.01695791631937027,
-0.027086522430181503,
0.05800299346446991,
0.013416364789009094,
0.05066610127687454,
-0.02745567448437214,
0.04582098126411438,
0.05223499611020088,
0.03050117753446102,
-0.05652638524770737,
-0.005822794511914253,
-0.01147254928946495,
-0.02498696930706501,
-0.09745610505342484,
0.0010404027998447418,
-0.018861355260014534,
-0.03735356032848358,
-0.00820209365338087,
0.00779256597161293,
-0.027640249580144882,
0.02549455314874649,
0.01308182068169117,
0.02812476083636284,
-0.01671566069126129,
0.007850246503949165,
-0.014339244924485683,
0.016854092478752136,
-0.004732642788439989,
0.008940397761762142,
-0.03829951211810112,
-0.04649006947875023,
0.033385176211595535,
-0.01280495710670948,
0.0005681478651240468,
0.018942108377814293,
-0.011132237501442432,
0.018942108377814293,
0.005782418884336948,
0.06843153387308121,
-0.02791711315512657,
-0.03880709409713745,
-0.0018991135293617845,
0.002262497553601861,
0.021676138043403625,
0.003564623184502125,
0.005124866962432861,
-0.0015977356815710664,
0.025402266532182693,
0.0023043155670166016,
-0.02678658626973629,
0.005234458949416876,
-0.009194189682602882,
0.0038847471587359905,
0.011559069156646729,
-0.03850715979933739,
-0.0132548613473773,
0.024663962423801422,
-0.009171118028461933,
0.0015256355982273817,
-0.030247384682297707,
0.012308909557759762,
-0.004086627159267664,
0.029116857796907425,
-0.010607349686324596,
-0.023037387058138847,
0.05223499611020088,
-0.034446489065885544,
0.008150181733071804,
-0.020187994465231895,
-0.0008515007793903351,
-0.002514847321435809,
0.02282973937690258,
-0.0010915937600657344,
0.030293529853224754,
0.007717582397162914,
0.04067592695355415,
0.007850246503949165,
-0.03213929012417793,
0.0361768864095211,
0.016415724530816078,
-0.01331254094839096,
0.01625422015786171,
0.038207221776247025,
-0.030224312096834183,
-0.03370818495750427,
-0.03590002283453941,
-0.008825037628412247,
-0.009361461736261845,
-0.03723819926381111,
0.047528307884931564,
-0.0069965822622179985,
-0.03151634335517883,
0.002349017420783639,
-0.01911514811217785,
0.05181970074772835,
-0.04367528483271599,
0.027640249580144882,
-0.0018385496223345399,
0.04099893569946289,
-0.006610126234591007,
0.0005753578734584153,
-0.011703269556164742,
-0.02204529009759426,
-0.047528307884931564,
0.033546678721904755,
-0.028055544942617416,
0.0007664228323847055,
0.023152746260166168,
-0.019080540165305138,
0.04582098126411438,
-0.01581585220992565,
0.0055026705376803875,
0.0023706473875790834,
0.03661525622010231,
0.02999359369277954,
0.013393293134868145,
0.04134501516819,
0.020026491954922676,
0.004020295105874538,
-0.0037203591782599688,
0.005231574643403292,
0.006373638287186623,
-0.019126683473587036,
0.01076885312795639,
0.024594746530056,
0.02028028294444084,
-0.0006049188668839633,
-0.0016453216085210443,
-0.03829951211810112,
0.04448280483484268,
0.05869515612721443,
0.07166161388158798,
-0.013520188629627228,
0.035692375153303146,
-0.025448409840464592,
-0.019726555794477463,
-0.03465413674712181,
-0.003953963052481413,
0.02960136905312538,
-0.020453322678804398,
-0.04083742946386337,
0.018469132483005524,
-0.02021106705069542,
0.02307199500501156,
-0.0023071994073688984,
0.0316317044198513,
0.04122965410351753,
-0.00783294253051281,
-0.030731895938515663,
-0.03536936640739441,
-0.01533134002238512,
0.01257423684000969,
0.03241615369915962,
-0.00849626213312149,
-0.0777987688779831,
0.014373852871358395,
-0.018630634993314743,
-0.000396549905417487,
0.014212348498404026,
-0.029301432892680168,
-0.016219612210989,
0.06557060778141022,
-0.03227772191166878,
0.035577014088630676,
0.023948730900883675,
0.000821939785964787,
0.0018587375525385141,
-0.030085880309343338,
-0.04067592695355415,
-0.042590901255607605,
0.021076267585158348,
-0.028170906007289886,
0.0181345883756876,
0.02953215315937996,
0.017200171947479248,
-0.04757445305585861,
-0.005649754777550697,
0.019807307049632072,
0.03015509620308876,
-0.013647085055708885,
-0.001580431591719389,
-0.018884427845478058,
-0.019126683473587036,
0.07553771138191223,
0.002158673480153084,
0.03412348031997681,
0.04582098126411438,
-0.02683272957801819,
-0.0070023504085838795,
-0.022079898044466972,
-0.029047641903162003,
-0.016392651945352554,
0.04969707503914833,
-0.003336787223815918,
0.013450972735881805,
-0.03128562495112419,
-0.0362691767513752,
0.04346763715147972,
-0.015181372873485088,
-0.02999359369277954,
-0.024179451167583466,
0.0336851105093956,
-0.020141851156949997,
0.007965605705976486,
-0.05158897861838341,
0.026186713948845863,
-0.04609784483909607,
-0.01996881142258644,
0.015158300288021564,
-0.017200171947479248,
0.03834565356373787,
0.024571673944592476,
-0.0004203428979963064,
0.052188850939273834,
-0.038161080330610275,
-0.053757745772600174,
-0.004703802987933159,
-0.01589660346508026,
0.029209144413471222,
-0.027755608782172203,
-0.043559927493333817,
-0.0025624334812164307,
0.06474001705646515,
-0.062248241156339645,
0.015089084394276142,
-0.024779321625828743,
0.036753688007593155,
-0.07290749996900558,
-0.0223221555352211,
-0.037030551582574844,
0.009442213922739029,
0.017592396587133408,
0.052650291472673416,
0.0032271952368319035,
-0.0017779855988919735,
0.00027938743005506694,
-0.0022509614937007427,
0.012262765318155289,
-0.0569416843354702,
-0.0038645591121166945,
-0.005211386829614639,
0.06031019240617752,
-0.053111732006073,
-0.01305874902755022,
0.02701730653643608,
0.00896923802793026,
-0.003316599177196622,
0.014143132604658604,
-0.003253151196986437,
0.016750268638134003,
0.015988891944289207,
0.0004873958823736757,
-0.017961548641324043,
-0.01210126094520092,
-0.0039337752386927605,
0.02505618706345558,
-0.030408889055252075,
-0.009407605975866318,
-0.011005341075360775,
-0.009667165577411652,
-0.016888700425624847,
0.0010634748032316566,
-0.024848537519574165,
-0.029970521107316017,
-0.0304319616407156,
0.030616536736488342,
-0.016819484531879425,
0.032646872103214264,
-0.006119846366345882,
0.0036511430516839027,
0.026232857257127762,
0.028932280838489532,
-0.022806666791439056,
0.0433061346411705,
0.003097415203228593,
0.019518908113241196,
-0.05763384327292442,
-0.024525530636310577,
0.028909210115671158,
0.00750993425026536,
0.0018428756156936288,
-0.01899978704750538,
-0.02572527341544628,
0.006494766566902399,
-0.006362102460116148,
0.002389393514022231,
0.0011946967570111156,
-0.012516557238996029,
-0.017084812745451927,
0.0007170343305915594,
-0.010578509420156479,
-0.011882076971232891,
-0.04353685304522514,
-0.03850715979933739,
-0.02886306494474411,
-0.04042213410139084,
0.010019013658165932,
-0.035577014088630676,
-0.006817774381488562,
-0.020960906520485878,
-0.04946635663509369,
-0.027201881632208824,
-0.040283702313899994,
0.016577228903770447,
-0.032877590507268906,
-0.028101690113544464,
-0.012424268759787083,
-0.019449692219495773,
0.024848537519574165,
0.011882076971232891,
-0.010347789153456688,
0.004178915172815323,
0.023395001888275146,
-0.026486650109291077,
0.00456248689442873,
0.0038299511652439833,
0.029970521107316017,
-0.025240762159228325,
0.0362691767513752,
0.005600726697593927,
0.02307199500501156,
-0.02004956267774105,
-0.012182013131678104,
-0.013427901081740856,
-0.012205084785819054,
-0.01347404532134533,
0.015515916049480438,
-0.022495195269584656,
0.025909850373864174,
-0.037192054092884064,
-0.0028522752691060305,
0.013439436443150043,
0.015204444527626038,
-0.010405469685792923,
-0.029855161905288696,
0.023787226527929306,
-0.014858364127576351,
0.01805383525788784,
0.011714804917573929,
-0.015123692341148853,
0.028724633157253265,
-0.017453964799642563,
-0.03223157674074173,
0.02447938546538353,
-0.029901305213570595,
0.005410382524132729,
-0.020118778571486473,
-0.02165306732058525,
-0.028424696996808052,
0.03802264854311943,
0.012205084785819054,
0.033777400851249695,
-0.04379064589738846,
-0.002739799441769719,
0.02487161010503769,
0.007429182063788176,
0.025240762159228325,
-0.02240290679037571,
0.029716728255152702,
-0.02259901911020279,
-0.026855802163481712,
0.010088229551911354,
-0.007954070344567299,
-0.013658620417118073,
-0.042037174105644226,
0.0291399285197258,
-0.01380858849734068,
-0.020349498838186264,
-0.0007184763089753687,
-0.02780175395309925,
-0.013185644522309303,
0.039891477674245834,
0.014593036845326424,
-0.04374450072646141,
0.00947682186961174,
-0.006419782526791096,
0.04252168536186218,
0.05103525146842003,
-0.056064948439598083,
-0.019565051421523094,
0.0002817306958604604,
0.0024153494741767645,
-0.035069432109594345,
-0.008484725840389729,
0.025033114477992058,
0.0057333908043801785,
-0.001095198793336749,
-0.005430570803582668,
-0.010803461074829102,
-0.0045913271605968475,
0.019715018570423126,
-0.04653621464967728,
-0.01939201168715954,
0.0015573595883324742,
0.024294810369610786,
-0.008876949548721313,
-0.027271097525954247,
-0.031862422823905945,
-0.0095345014706254,
0.03643067926168442,
0.0084212776273489,
-0.030085880309343338,
0.02052253857254982,
-0.012320444919168949,
0.013139501214027405,
0.0030916472896933556,
-0.018157659098505974,
-0.0031522111967206,
-0.012654989026486874,
-0.038437943905591965,
0.0005555303650908172,
-0.02201068215072155,
-0.035507798194885254,
-0.006898526567965746,
-0.010751549154520035,
-0.002797479275614023,
-0.015031404793262482,
-0.028540058061480522,
0.023083530366420746,
0.011859005317091942,
0.0032762233167886734,
-0.012781885452568531,
0.0059035466983914375,
-0.011835933662950993,
0.02953215315937996,
0.06104849651455879,
-0.03696133568882942,
0.014120060950517654,
-0.02662508189678192,
-0.011974365450441837,
-0.015688955783843994,
0.029047641903162003,
0.0014701186446473002,
-0.01895364373922348,
0.0023519014939665794,
0.013358685187995434,
0.04900491610169411,
0.007561846170574427,
0.023833369836211205,
-0.02740952931344509,
0.023360393941402435,
0.02349882572889328,
0.0015847575850784779,
-0.03077804110944271,
-0.017327068373560905,
-0.012262765318155289,
0.012954925186932087,
-0.006448622327297926,
-0.030293529853224754,
-0.04895877093076706,
0.02784789726138115,
0.012066652998328209,
0.004262551199644804,
-0.007469558157026768,
0.0111841494217515,
-0.0028003633487969637,
0.003570391098037362,
-0.030524248257279396,
-0.036015383899211884,
0.003359859110787511,
-0.02216065116226673,
0.026025209575891495,
0.006223670672625303,
-0.010572741739451885,
-0.03532322496175766,
-0.07184619456529617,
0.03093954548239708,
0.016969451680779457,
0.022252939641475677,
-0.03578466549515724,
0.03592309728264809,
-0.02150309830904007,
-0.003429075237363577,
-0.009107669815421104,
0.02318735420703888,
-0.01035932544618845,
-0.01482375618070364,
0.00413277093321085,
-0.016104253008961678,
0.0011471107136458158,
0.010267037898302078,
0.004343302920460701,
-0.009920957498252392,
0.04923563823103905,
0.010924589820206165,
0.01533134002238512,
-0.011443709023296833,
0.006379406433552504,
-0.013600940816104412,
-0.009436446242034435,
0.028770776465535164,
0.008161718025803566,
-0.047482166439294815,
0.044390518218278885,
-0.04762059822678566,
-0.005297906696796417,
0.013116428628563881,
0.01030164584517479,
-0.006725486367940903,
-0.004115466959774494,
-0.036130744963884354,
0.05486520379781723,
-0.013935484923422337,
-0.06330955028533936,
0.021364666521549225,
-0.0023720895405858755,
0.031124120578169823,
-0.025563770905137062,
-0.07060030102729797,
-0.00820209365338087,
-0.02408716268837452,
0.029947448521852493,
0.013797053135931492,
-0.0155274523422122,
-0.001852969522587955,
-0.005675710737705231,
0.0034060031175613403,
0.007682973984628916,
-0.014120060950517654,
-0.008173254318535328,
0.015919676050543785,
-0.009153814055025578,
-0.0005562513833865523,
-0.01499679684638977,
-0.020257210358977318,
-0.016127323731780052,
-0.05334245041012764,
0.0001901637006085366,
-0.003005127189680934,
-0.02791711315512657,
-0.01766161248087883,
-0.003068575169891119,
0.029970521107316017,
0.012032045051455498,
0.00045459039392881095,
0.01793847605586052,
-0.006875454448163509,
-0.036246102303266525,
0.01499679684638977,
-0.03677675873041153,
-0.0061717587523162365,
0.006483230274170637,
-0.025794489309191704,
0.04279854893684387,
-0.0008392438176088035,
0.0027051912620663643,
-0.006067934446036816,
-0.009528733789920807,
-0.019841914996504784,
0.01153599750250578,
-0.01235505286604166,
0.006200598552823067,
0.008819269947707653,
0.04049134999513626,
-0.020626362413167953,
0.0012091167736798525,
0.013427901081740856,
0.02992437779903412,
-0.03853023052215576,
0.028217049315571785,
-0.01527366042137146,
0.03654604032635689,
0.021999146789312363,
-0.07479940354824066,
-0.02385644242167473,
-0.014927580952644348,
-0.016219612210989,
-0.02068404294550419,
0.006852382328361273,
-0.03423884138464928,
-0.0017664495389908552,
0.03670754283666611,
0.010584277100861073,
0.017800044268369675,
-0.044828884303569794,
-0.005341166630387306,
0.01766161248087883,
0.01184746902436018,
0.008098269812762737,
-0.008980774320662022,
-0.05260414630174637,
-0.0005378658534027636,
0.023129675537347794,
0.005263298749923706,
0.01555052399635315,
0.0035617391113191843,
0.028286265209317207,
0.00715808616951108,
0.017165564000606537,
0.0010685217566788197,
-0.03133177012205124,
-0.03059346415102482,
-0.0017837536288425326,
-0.022310618311166763,
0.011011109687387943,
-0.0017924056155607104,
0.03615381568670273,
-0.016219612210989,
-0.0350232869386673,
0.013750908896327019,
-0.014454605057835579,
0.028724633157253265,
0.015515916049480438,
0.018584491685032845,
0.001385761657729745,
0.03677675873041153,
0.01207818929105997,
-0.016819484531879425,
-0.015492844395339489,
-0.02212604321539402,
0.003434843150898814,
0.016704123467206955,
-0.01127643696963787,
0.0035098271910101175,
-0.030408889055252075,
-0.03054732084274292,
0.00481627881526947,
0.0077406540513038635,
-0.04808203503489494,
0.028955353423953056,
-0.006979278288781643,
0.004969130735844374,
-0.0024312115274369717,
-0.015412092208862305,
0.02874770574271679,
0.0042337109334766865,
-0.010174749419093132,
-0.02683272957801819,
-0.019830379635095596,
-0.03250844031572342,
0.03082418441772461,
-0.03862252086400986,
0.0036540271248668432,
-0.019911130890250206,
0.01255116518586874,
-0.04279854893684387,
0.05666481703519821,
-0.010740013793110847,
0.019299723207950592,
-0.021410811692476273,
0.0025797374546527863,
-0.004380795173346996,
0.03903781622648239,
-0.04053749516606331,
-0.03470027819275856,
-0.03038581646978855,
-0.002364879474043846,
-0.011760949157178402,
-0.0015761055983603,
0.018076907843351364,
-0.014419996179640293,
0.02130698785185814,
-0.008882718160748482,
0.014777612872421741,
-0.023279642686247826,
0.0021168554667383432,
0.03050117753446102,
0.004617283120751381,
-0.023371931165456772,
0.005759346764534712,
-0.008080965839326382,
-0.006442854646593332,
-0.003022431395947933,
0.025517625734210014,
-0.035507798194885254,
-0.005453642923384905,
-0.009274941869080067,
-0.01061311736702919,
-0.010267037898302078,
0.038945525884628296,
0.011772485449910164,
0.0031695151701569557,
-0.049281779676675797,
0.025817561894655228,
0.008796198293566704,
0.03183935210108757,
-0.014846828766167164,
0.0004318788996897638,
0.02153770625591278,
0.04729758948087692,
-0.024733178317546844,
0.014616108499467373,
-0.029301432892680168,
0.06529374420642853,
0.015100620687007904,
0.00003255764750065282,
-0.010572741739451885,
-0.019864987581968307,
0.004245247226208448,
0.008761590346693993,
0.01300106942653656,
-0.01582738757133484,
0.0168425552546978,
0.02533305063843727,
-0.0001858377072494477,
0.016657980158925056,
-0.013162572868168354,
-0.006961974315345287,
-0.00019611195602919906,
0.0033973511308431625,
0.007688742130994797,
0.005716086830943823,
0.02706344984471798,
0.016115788370370865,
0.007100406568497419,
-0.0025018693413585424,
0.011195685714483261,
0.024640889838337898,
-0.014927580952644348,
-0.05223499611020088,
0.0019380475860089064,
0.029001496732234955,
-0.0155274523422122,
0.0020072634797543287,
0.007919462397694588,
0.02443324215710163,
0.0362691767513752,
0.012597309425473213,
0.0271788090467453,
0.027086522430181503,
-0.0048970310017466545,
-0.0556957945227623,
0.020649434998631477,
-0.00947682186961174,
0.02752489037811756,
-0.017834652215242386,
-0.03250844031572342,
0.007394574116915464,
-0.007238838355988264,
-0.007977141998708248,
0.01300106942653656,
0.0343080572783947,
0.03952232748270035,
-0.014327708631753922,
-0.04111429303884506,
0.07692202925682068,
0.0188036747276783,
-0.0020707114599645138,
0.01833069883286953,
-0.005600726697593927,
-0.021918395534157753,
0.014270029030740261,
0.03232386335730553,
0.005779534578323364,
-0.0181345883756876,
-0.0007065798272378743,
0.04155266284942627,
0.01159367710351944,
-0.05726468935608864,
-0.025033114477992058,
-0.02060329169034958,
0.021076267585158348,
0.012908780947327614,
-0.014362316578626633,
0.004571138881146908,
0.013993164524435997,
0.04817432537674904,
0.01076885312795639,
-0.01954197883605957,
0.0052027348428964615,
0.02678658626973629,
-0.046628501266241074,
-0.0284708421677351,
-0.026648154482245445,
0.03553087264299393,
0.034954071044921875,
-0.025540698319673538,
-0.02361418679356575,
0.01286263670772314,
0.003691519144922495,
-0.050619956105947495,
-0.04868190735578537,
0.016035037115216255,
-0.009592182002961636,
0.06275582313537598,
-0.03423884138464928,
0.02807861752808094,
-0.02291049063205719,
0.046190131455659866,
-0.01746550016105175,
0.024779321625828743,
-0.03903781622648239,
-0.014189276844263077,
-0.03497714549303055,
-0.041460372507572174,
-0.016554156318306923,
-0.03400811925530434,
0.013462509028613567,
0.00949989352375269,
0.02757103368639946,
-0.01353172492235899,
0.022702842950820923,
0.008507798425853252,
0.0005580538418143988,
0.02953215315937996,
0.00571897067129612,
0.015688955783843994,
0.0031954713631421328,
0.021330058574676514,
-0.02577141858637333,
-0.012147405184805393,
-0.005566118750721216,
0.009055757895112038,
0.06054091453552246,
0.026740441098809242,
0.013139501214027405,
-0.05029694736003876,
0.0034896391443908215,
0.005075838882476091,
0.058418288826942444,
-0.04547490179538727,
-0.036753688007593155,
-0.022195259109139442,
-0.0001845759543357417,
0.009344157762825489,
0.019045932218432426,
0.031354840844869614,
0.015308268368244171,
0.03174706548452377,
0.00834052637219429,
0.0223221555352211,
0.014246956445276737,
0.0026287653017789125,
-0.007204230409115553,
-0.017061740159988403,
-0.029693657532334328,
-0.014362316578626633,
0.028401626273989677,
0.01836530864238739,
0.005580538883805275,
-0.029624441638588905,
-0.005675710737705231,
0.021214699372649193,
0.014304636977612972,
0.020511003211140633,
-0.015377484261989594,
-0.017800044268369675,
0.0064659263007342815,
-0.0367998331785202,
0.01620807684957981,
-0.022056827321648598,
0.031354840844869614,
0.004882610868662596,
-0.03156248852610588,
0.006604358553886414,
-0.0034031192772090435,
0.011582141742110252,
0.013866269029676914,
0.007994445972144604,
-0.02796325832605362,
-0.0013093356974422932,
-0.00025325120077468455,
-0.036199960857629776,
-0.015677420422434807,
-0.003691519144922495,
-0.009292245842516422,
-0.008565478026866913,
-0.0024629354011267424,
-0.017996156588196754,
0.014685324393212795,
-0.007238838355988264,
-0.00020386269898153841,
-0.013577869161963463,
0.00650053471326828,
0.01602349989116192,
-0.0031839353032410145,
-0.0024153494741767645,
0.005563234910368919,
-0.015688955783843994,
-0.004614398814737797,
-0.04554411768913269,
-0.007648366037756205,
0.009794062003493309,
-0.04475966840982437,
0.03896860033273697,
0.008357830345630646,
-0.012920317240059376,
0.014650716446340084,
0.016900235787034035,
-0.0011535997036844492,
-0.001711653545498848,
0.009240333922207355,
0.01096496544778347,
0.0011781137436628342,
0.003033967223018408,
0.002806131262332201,
0.0013259187107905746,
-0.005701666697859764,
-0.004729758948087692,
-0.009049990214407444,
0.020061099901795387,
-0.0362691767513752,
-0.03590002283453941,
0.025171546265482903,
-0.008853877894580364,
0.015239052474498749,
-0.014985260553658009,
0.012770349159836769,
0.012954925186932087,
-0.012170476838946342,
0.017961548641324043,
-0.007331126369535923,
-0.013670156709849834,
-0.004158726893365383,
0.0165310837328434,
-0.00042106391629204154,
0.013658620417118073,
0.023510362952947617,
-0.001969771459698677,
-0.004155843053013086,
-0.026186713948845863,
0.007844477891921997,
-0.02138773910701275,
0.055557362735271454,
-0.022310618311166763,
-0.049558643251657486,
0.03936082124710083,
0.026532793417572975,
0.0007959838258102536,
0.016104253008961678,
0.000021607464077533223,
-0.017096348106861115,
0.02639436163008213,
-0.004954711068421602,
0.008859645575284958,
0.020960906520485878,
-0.03631531819701195,
0.012562701478600502,
0.015089084394276142,
-0.03488485515117645,
-0.007048494182527065,
0.008709678426384926,
-0.0021875135134905577,
0.00034770218189805746,
0.03391583263874054,
-0.028055544942617416,
-0.0033829312305897474,
-0.006148686632514,
0.030985688790678978,
0.041183508932590485,
0.018030764535069466,
0.007942534051835537,
0.03610767051577568,
-0.013947021216154099,
-0.001547265681438148,
-0.009903653524816036,
0.006956206168979406,
-0.013831661082804203,
-0.025240762159228325,
-0.06677035242319107,
-0.005444990936666727,
0.010365093126893044,
-0.007336894515901804,
0.0290937852114439,
0.010070925578474998,
0.017800044268369675,
0.01687716320157051,
-0.015262124128639698,
-0.03301602602005005,
0.03156248852610588,
0.008173254318535328,
-0.024502458050847054,
-0.032439224421978,
-0.03156248852610588,
-0.03373125568032265,
0.007106174249202013,
0.00041854041046462953,
0.0064659263007342815,
0.011760949157178402,
0.01911514811217785,
0.029047641903162003,
0.0074349502101540565,
-0.003172399243339896,
-0.02494082599878311,
-0.013554796576499939,
-0.059156592935323715,
0.009701773524284363,
-0.02443324215710163,
-0.020926298573613167,
-0.0026388594415038824,
-0.029624441638588905,
-0.04032984748482704,
-0.01715402863919735,
0.01723477989435196,
-0.002685003448277712,
0.01035932544618845,
0.007642598357051611,
-0.013358685187995434,
-0.017673147842288017,
0.005992950405925512,
0.029116857796907425,
-0.0036597950384020805,
0.018584491685032845,
0.024848537519574165,
-0.007804102264344692,
0.007579150144010782,
-0.019172826781868935,
-0.029070712625980377,
-0.012182013131678104,
-0.005450758617371321,
-0.003172399243339896,
-0.018584491685032845,
0.02740952931344509,
0.0028292033821344376,
0.011720573529601097,
0.034561846405267715,
0.023048922419548035,
0.023429609835147858,
-0.020418714731931686,
-0.01372783724218607,
-0.013554796576499939,
0.017327068373560905,
0.018376844003796577,
0.010993805713951588,
0.0420602448284626,
-0.031031832098960876,
-0.01327793300151825,
-0.005225806962698698,
-0.010030549950897694,
-0.02302584983408451,
0.0007642598357051611,
0.021629994735121727,
0.004063555039465427,
-0.02146849036216736,
0.008190558291971684,
-0.021007051691412926,
-0.004429822787642479,
0.01257423684000969,
0.01353172492235899,
0.004173147026449442,
0.010889981873333454,
-0.007290750276297331,
-0.007873318158090115,
0.024802394211292267,
0.001971213612705469,
0.005580538883805275,
0.010526597499847412,
0.009217262268066406,
-0.036199960857629776,
0.0367998331785202,
0.01671566069126129,
0.0049835508689284325,
-0.025309978052973747,
-0.04201410338282585,
0.01864217221736908,
-0.0025508974213153124,
-0.003322367323562503,
0.02338346652686596,
0.03303909674286842,
0.010630421340465546,
-0.012920317240059376,
0.033108312636613846,
0.008790429681539536,
-0.01645033247768879,
-0.009090365841984749,
-0.013554796576499939,
0.0027181694749742746,
-0.016311900690197945,
-0.006863918621093035,
0.015735100954771042,
-0.028263192623853683,
-0.00574781047180295,
-0.018353771418333054,
-0.01210126094520092,
-0.008069430477917194,
0.005130634643137455,
-0.018111515790224075,
0.019726555794477463,
0.014154668897390366,
-0.021214699372649193,
-0.05920273810625076,
-0.01454689260572195,
-0.009776758030056953,
-0.046974580734968185,
-0.00012130822142353281,
-0.017788507044315338,
0.021122410893440247,
0.05094296485185623,
-0.011489853262901306,
0.019588124006986618,
0.05666481703519821,
0.0367998331785202,
0.01872292347252369,
0.03913010284304619,
0.022806666791439056,
0.002679235301911831,
-0.02291049063205719,
-0.033546678721904755,
-0.006085238419473171,
-0.004002991132438183,
0.037768855690956116,
-0.02644050493836403,
0.015458236448466778,
0.018157659098505974,
-0.010347789153456688,
0.003783807158470154,
-0.021676138043403625,
-0.025586841627955437,
0.020545611158013344,
0.0033050631172955036,
-0.004585559014230967,
-0.005906430538743734,
-0.0073022861033678055,
-0.021987611427903175,
-0.003365627257153392,
0.023994874209165573,
-0.015158300288021564,
0.016473405063152313,
0.015158300288021564,
0.04060671105980873,
-0.032762233167886734,
-0.0031781671568751335,
0.030524248257279396,
0.031308695673942566,
-0.0033108312636613846,
0.01546977274119854,
0.012770349159836769,
-0.018538348376750946,
-0.0032906432170420885,
0.019715018570423126,
0.028147833421826363,
-0.05791070684790611,
0.014777612872421741,
0.023718010634183884,
-0.017673147842288017,
-0.0095345014706254,
0.013520188629627228,
0.01785772293806076,
0.01589660346508026,
-0.006950438488274813,
-0.006546678487211466,
-0.0002802886883728206,
0.012747276574373245,
-0.01715402863919735,
-0.02079940401017666,
-0.0034117712639272213,
0.016946380957961082,
-0.02436402626335621,
0.00665627047419548,
-0.0013071727007627487,
0.0031060671899467707,
0.012493484653532505,
0.008992309682071209,
-0.019103610888123512,
-0.02385644242167473,
-0.01127643696963787,
0.0017707755323499441,
-0.0023317134473472834,
-0.022276010364294052,
-0.04644392430782318,
-0.024294810369610786,
0.009592182002961636,
-0.005395962856709957,
-0.05749541148543358,
0.01816919632256031,
-0.029462937265634537,
-0.018076907843351364,
0.011189917102456093,
0.04076821357011795,
-0.008236702531576157,
-0.007631062064319849,
-0.02130698785185814,
0.01384319644421339,
0.0033483232837170362,
0.017061740159988403,
-0.024733178317546844,
-0.045567188411951065,
-0.004325998947024345,
0.019218971952795982,
-0.03799957409501076,
-0.02169921062886715,
-0.030639609321951866,
0.0019322795560583472,
-0.035230934619903564,
-0.0036367231514304876,
0.02897842600941658,
-0.006748558487743139,
-0.004548066761344671,
0.03384661674499512,
-0.0335928238928318,
-0.006933134514838457,
-0.0029445632826536894,
0.03799957409501076,
0.016588764265179634,
0.018699850887060165,
-0.03347746282815933,
-0.023591114208102226,
-0.023741083219647408,
0.02161845937371254,
-0.011916684918105602,
0.017211707308888435,
0.043490711599588394,
0.01754625141620636,
-0.0058141425251960754,
0.016911771148443222,
0.012032045051455498,
-0.042983125895261765,
-0.011732108891010284,
-0.019680410623550415,
-0.026532793417572975,
-0.0031522111967206,
-0.041644949465990067,
0.02886306494474411,
0.02118009142577648,
0.009995942004024982,
-0.016773339360952377,
-0.004475967027246952,
-0.029970521107316017,
0.002233657520264387,
-0.016231147572398186,
-0.0184922032058239,
0.004848002921789885,
-0.012458876706659794,
-0.05251185968518257,
0.004441359080374241,
0.0006463763420470059,
-0.0016337856650352478,
0.025309978052973747,
0.01879213936626911,
-0.0001982749527087435,
-0.018111515790224075,
-0.01586199551820755,
-0.010895749554038048,
0.004790322855114937,
-0.0033396712969988585,
-0.013773980550467968,
0.021364666521549225,
0.01586199551820755,
-0.0007527238340117037,
0.030201241374015808,
0.020568683743476868,
-0.02964751236140728,
-0.005419034510850906,
-0.0252176895737648,
0.009765221737325191,
-0.010716941207647324,
-0.014120060950517654,
0.077706478536129,
-0.016900235787034035,
-0.017569324001669884,
-0.003997222986072302,
-0.01934586837887764,
-0.020568683743476868,
0.02549455314874649,
-0.019022859632968903,
0.026186713948845863,
0.0001651089551160112,
0.012412733398377895,
-0.009326853789389133,
0.019080540165305138,
0.03594616800546646,
0.001385761657729745,
-0.00824247021228075,
-0.012943388894200325,
0.017603931948542595,
0.0009113437845371664,
-0.021987611427903175,
-0.004176030866801739,
0.00896923802793026,
-0.002134159440174699,
0.019438154995441437,
-0.01448921300470829,
-0.017926940694451332,
-0.028401626273989677,
-0.006281350739300251,
-0.0002826319250743836,
-0.00004102939783479087,
0.004876842722296715,
0.009569109417498112,
0.00859431829303503,
-0.004698034841567278,
0.02001495473086834,
-0.010549669153988361,
-0.021480027586221695,
-0.014143132604658604,
0.0030801112297922373,
0.015412092208862305,
0.0006845893221907318,
0.0048018586821854115,
-0.0003633839078247547,
-0.006973510608077049,
0.025979066267609596,
0.010543901473283768,
-0.02475625090301037,
-0.014881436713039875,
-0.005992950405925512,
-0.010924589820206165,
-0.0012127216905355453,
-0.006454390473663807,
0.017084812745451927,
0.003054155269637704,
-0.019022859632968903,
-0.006546678487211466,
0.03398504853248596,
-0.018699850887060165,
0.003506943117827177,
-0.03684597462415695,
-0.028286265209317207,
0.025586841627955437,
0.03423884138464928,
-0.0020404295064508915,
0.01141486968845129
] | 2024-07-13 | 31 | 39000281 | [
"autologous T cells",
"CAR)-T cell treatment",
"GBM patients",
"GBM",
"recurrent GBM",
"CAR-T cell therapy",
"antigen escape",
"chimeric antigen receptor",
"combination therapies",
"CAR-T cell efficacy",
"particular antigens",
"CAR-T cells",
"antigens",
"EGFRvIII CAR-T cells",
"preclinical studies",
"CAR-T cell types",
"other brain tumors",
"tumor heterogeneity",
"clinical trials",
"personalized approaches",
"potential approaches",
"a GBM antigen",
"antigen-targeted therapy",
"Innovative delivery methods",
"these CAR-T cell treatments",
", \"T cell therapy",
"tumors",
"intrinsic pontine gliomas",
"Ongoing research",
"new developments"
] | [
"CAR T cell",
"glioblastoma",
"immunotherapy",
"molecular targets",
"systematic reviews"
] | 0 | 10.3390/ijms25137174
10.1080/21645515.2022.2055417
10.1007/s00262-013-1453-3
10.1097/01.jnen.0000178445.33972.a9
10.3390/cancers15051414
10.1136/bmj.n71
10.1007/s10654-010-9491-z
10.1001/jamaoncol.2017.0184
10.1158/1078-0432.CCR-15-0428
10.1056/NEJMoa1610497
10.1126/scitranslmed.aaa0984
10.3389/fonc.2021.694941
10.1038/s41416-018-0342-0
10.1097/CJI.0000000000000260
10.1186/s12943-022-01711-9
10.3390/ijms242015037
10.3390/biology12050736
10.1126/science.aar6711
10.1056/NEJMoa1407222
10.1172/jci.insight.96976
10.1016/j.cell.2016.01.011
10.1038/nrclinonc.2017.148
10.7150/ijbs.85813
10.1158/1078-0432.CCR-18-0432
10.1016/j.ccell.2019.01.002
10.1038/s41388-017-0045-7
10.1093/neuonc/noab182
10.3389/fimmu.2021.715000
10.4252/wjsc.v16.i5.604
10.3390/ijms25020724 | [
"Agosti",
"Garaba",
"Antonietti",
"Ius",
"Fontanella",
"Zeppieri",
"Panciani"
] | [
"Division of Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy.",
"Division of Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy.",
"Division of Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy.",
"Neurosurgery Unit, Head-Neck and NeuroScience Department, University Hospital of Udine, p.le S. Maria della Misericordia 15, 33100 Udine, Italy.",
"Division of Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy.",
"Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, 33100 Udine, Italy.",
"Division of Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy."
] | [
"39000281",
"35344682",
"23817721",
"16141784",
"36900205",
"33782057",
"20652370",
"28426845",
"26059190",
"28029927",
"28724573",
"34235085",
"30478409",
"30882547",
"36617554",
"37894718",
"37237548",
"29567707",
"25317870",
"29321369",
"26830879",
"28925994",
"37564196",
"30655315",
"30753824",
"29321659",
"34347086",
"32913543",
"34819930",
"38817336",
"38255798"
] | [] | 10.087312 | 7.413597 |
38996463 | 733 | CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study. | Outcomes are poor for patients with large B-cell lymphoma who relapse after CD19-directed chimeric antigen receptor (CAR) T-cell therapy (CAR19). CD22 is a nearly universally expressed B-cell surface antigen and the efficacy of a CD22-directed CAR T-cell therapy (CAR22) in large B-cell lymphoma is unknown, which was what we aimed to examine in this study.
In this single centre, open-label, dose-escalation phase 1 trial, we intravenously administered CAR22 at two dose levels (1 million and 3 million CAR22-positive T cells per kg of bodyweight) to adult patients (aged ≥18 years) who relapsed after CAR19 or had CD19-negative large B-cell lymphoma. The primary endpoints were manufacturing feasibility, safety measured by the incidence and severity of adverse events and dose-limiting toxicities, and identification of the maximum tolerated dose (ie, the recommended phase 2 dose). This study is registered with ClinicalTrials.gov (NCT04088890) and is active, but closed for enrolment.
From Oct 17, 2019, to Oct 19, 2022, a total of 41 patients were assessed for eligibility; however, one patient withdrew. 40 patients underwent leukapheresis and 38 (95%) had CAR T-cell products manufactured successfully. The median age was 65 years (range 25-84), 17 (45%) were women, 32 (84%) had elevated pretreatment lactate dehydrogenase, 11 (29%) had refractory disease to all previous therapies, and patients had received a median of four lines of previous therapy (range 3-8). Of the 38 patients treated, 37 (97%) had relapsed after previous CAR19. The identified maximum tolerated dose was 1 million CAR T cells per kg. Of 29 patients who received the maximum tolerated dose, no patients developed a dose-limiting toxicity or grade 3 or higher cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, or immune effector cell-associated haemophagocytic lymphohistiocytosis-like syndrome.
This trial identifies CD22 as an immunotherapeutic target in large B-cell lymphoma and demonstrates the durable clinical activity of CAR22 in patients with disease progression after CAR19 therapy. Although these findings are promising, it is essential to recognise that this is a phase 1 dose-finding study. Further investigations are warranted to establish the long-term efficacy and to delineate the patient subgroups that will derive the most benefit from this therapeutic approach.
National Cancer Institute, National Institutes of Health, Stanford Cancer Institute, Leukemia & Lymphoma Society, Parker Institute for Cancer Immunotherapy, Lymph & Co, and the European Hematology Association. | [
0.04086511582136154,
0.011200211010873318,
0.04129958152770996,
0.029287945479154587,
-0.025403331965208054,
0.003062008647248149,
-0.005175225902348757,
-0.010369619354605675,
-0.018618034198880196,
-0.023307684808969498,
0.005485100671648979,
-0.02967129461467266,
-0.07258094847202301,
0.012886951677501202,
0.03071911819279194,
-0.03874391317367554,
0.05226339399814606,
0.0045107523910701275,
0.0061495741829276085,
0.03010575845837593,
0.00790340080857277,
0.009059839881956577,
-0.02645115554332733,
-0.016854625195264816,
-0.0036609931848943233,
-0.062613844871521,
0.02182539738714695,
-0.004223240073770285,
0.017697995528578758,
-0.05078110471367836,
0.03181805461645126,
-0.01919306069612503,
-0.03307033330202103,
0.03082134574651718,
-0.007769227959215641,
0.020662568509578705,
0.04173404350876808,
0.000988723710179329,
-0.037440523505210876,
-0.016944073140621185,
0.007954513654112816,
-0.0067277937196195126,
0.041095126420259476,
0.057553622871637344,
-0.05474238842725754,
-0.022093743085861206,
0.017429649829864502,
-0.0653739646077156,
0.022055407986044884,
-0.016816290095448494,
-0.018656369298696518,
-0.02663005143404007,
-0.030744675546884537,
0.039766181260347366,
-0.04641091451048851,
0.05862700194120407,
-0.0060856821946799755,
0.015755686908960342,
0.0054052360355854034,
-0.013353360816836357,
0.027550091966986656,
-0.008107854053378105,
0.026221144944429398,
-0.0421685092151165,
-0.049375489354133606,
-0.007596720475703478,
-0.047228727489709854,
-0.015244554728269577,
0.022592097520828247,
0.012548325583338737,
-0.00883621908724308,
-0.017697995528578758,
0.0016388215590268373,
0.022029850631952286,
0.02365269884467125,
0.03220140561461449,
-0.005945120472460985,
0.015193440951406956,
0.0015725339762866497,
-0.020611455664038658,
-0.02225986123085022,
0.004587422590702772,
-0.020164214074611664,
-0.04756096377968788,
0.0017857723869383335,
-0.02424050308763981,
0.03301921859383583,
-0.04324188828468323,
-0.029211275279521942,
0.008420922793447971,
-0.0096412543207407,
-0.0046768710017204285,
-0.039203934371471405,
0.04112068563699722,
-0.025965578854084015,
-0.006069709546864033,
0.012797502800822258,
-0.051854487508535385,
0.025428887456655502,
0.03263586759567261,
0.025940021499991417,
0.02356325089931488,
-0.004236018285155296,
-0.030284656211733818,
0.005226339213550091,
0.000026330359105486423,
-0.04697316139936447,
0.004964383319020271,
0.03869279846549034,
-0.028444575145840645,
0.040072862058877945,
0.016266820952296257,
0.006708626169711351,
0.052442289888858795,
-0.007143089547753334,
-0.045593101531267166,
-0.028291234746575356,
-0.02417661063373089,
0.0030859680846333504,
0.027856770902872086,
-0.03189472481608391,
0.0378238745033741,
0.008408145047724247,
-0.020688125863671303,
0.031792499125003815,
-0.008702046237885952,
0.06240938976407051,
-0.008222859352827072,
-0.02467496693134308,
-0.06384056806564331,
0.0356004424393177,
0.00589720206335187,
0.024444956332445145,
-0.02043255791068077,
-0.08551262319087982,
-0.005689553916454315,
-0.028112338855862617,
-0.0018592478008940816,
-0.02232375182211399,
-0.029773522168397903,
0.0232821274548769,
-0.028981264680624008,
0.0007048050756566226,
0.007986459881067276,
-0.05407791584730148,
-0.04436638206243515,
-0.012318315915763378,
0.03153693303465843,
0.01673961989581585,
0.028163451701402664,
-0.024291615933179855,
0.05847366526722908,
0.037619419395923615,
0.02045811526477337,
-0.008900110609829426,
-0.05806475877761841,
-0.006708626169711351,
0.06010929122567177,
-0.0085550956428051,
-0.032533641904592514,
-0.007730892859399319,
-0.013647262006998062,
-0.01721241883933544,
-0.025058316066861153,
0.026374485343694687,
0.021838175132870674,
-0.012656941078603268,
0.0011109166080132127,
-0.07191647589206696,
0.02406160533428192,
-0.0029326279181987047,
0.006810852792114019,
-0.07370544224977493,
-0.06194937229156494,
-0.06021151691675186,
-0.010797693394124508,
0.021339820697903633,
0.003520431462675333,
-0.029926862567663193,
-0.04352300986647606,
0.005695943254977465,
-0.0048302109353244305,
0.043548569083213806,
-0.0327892079949379,
-0.04219406470656395,
0.014541746117174625,
-0.014656750485301018,
0.010874363593757153,
-0.035395991057157516,
-0.004753540735691786,
0.018528586253523827,
-0.02334601990878582,
0.0844903513789177,
0.019423069432377815,
-0.00846564769744873,
-0.022400422021746635,
0.04743318259716034,
0.018004674464464188,
-0.038360562175512314,
-0.02821456454694271,
0.01608792506158352,
-0.025748346000909805,
-0.018963050097227097,
-0.04863434657454491,
-0.006296524778008461,
-0.03682716190814972,
-0.006306108552962542,
0.035549331456422806,
0.0055074626579880714,
-0.0189374927431345,
0.03286587819457054,
0.01229275856167078,
-0.03258475661277771,
0.0334281250834465,
-0.030080201104283333,
-0.008880943059921265,
-0.05032108724117279,
0.038181666284799576,
0.028776811435818672,
0.031664714217185974,
0.004973967093974352,
-0.003577933879569173,
-0.016190150752663612,
0.01971697248518467,
-0.010145998559892178,
0.017838556319475174,
0.01912916824221611,
-0.037747204303741455,
0.0028272068593651056,
-0.025249991565942764,
-0.009104563854634762,
-0.003964478615671396,
0.0326869823038578,
-0.03473151475191116,
-0.044315267354249954,
-0.014810090884566307,
0.009251515381038189,
0.03240586072206497,
0.051011115312576294,
-0.037031617015600204,
0.004906880669295788,
-0.005098555702716112,
0.02703895792365074,
0.010018215514719486,
0.0034341777209192514,
-0.01941029168665409,
0.014426740817725658,
-0.06614066660404205,
0.03503819555044174,
-0.018503030762076378,
-0.008273972198367119,
-0.015679018571972847,
-0.031076911836862564,
-0.05852477625012398,
0.011302437633275986,
-0.01337891723960638,
0.02719229832291603,
-0.021135367453098297,
0.01246526651084423,
-0.02132704295217991,
0.020291997119784355,
-0.01403061207383871,
-0.03997063264250755,
-0.050142187625169754,
-0.061029329895973206,
0.026860062032938004,
0.021429268643260002,
0.03378592059016228,
-0.003501263912767172,
0.009225958026945591,
0.015372337773442268,
0.0046257576905190945,
0.0538223497569561,
-0.005817337427288294,
-0.042270734906196594,
0.01682906784117222,
0.024943310767412186,
0.03432260826230049,
-0.00012059554137522355,
0.0101843336597085,
-0.00668945861980319,
0.03419482707977295,
-0.04252630099654198,
-0.05903591215610504,
0.015167884528636932,
-0.013877272605895996,
0.016854625195264816,
-0.025122208520770073,
-0.027958998456597328,
0.0042551858350634575,
0.011941354721784592,
-0.0005518643883988261,
-0.024074384942650795,
-0.016854625195264816,
-0.029006822034716606,
-0.01098936889320612,
0.03097468614578247,
-0.023269349709153175,
-0.020010873675346375,
0.039817292243242264,
-0.026055026799440384,
0.05908702313899994,
0.01215219683945179,
-0.04076289013028145,
-0.024662187322974205,
0.04201516881585121,
0.006964192725718021,
0.03698050230741501,
0.011768846772611141,
0.05190559849143028,
0.0112704923376441,
0.041682932525873184,
0.03138359263539314,
0.01810690201818943,
-0.0028048446401953697,
0.005600105505436659,
0.011034092865884304,
-0.05745139718055725,
0.0017234779661521316,
-0.031230252236127853,
-0.006683069746941328,
-0.010663521476089954,
-0.02703895792365074,
0.011743290349841118,
0.004117818549275398,
-0.04076289013028145,
0.017404092475771904,
-0.006226243916898966,
0.003769608912989497,
-0.041682932525873184,
0.020113099366426468,
-0.05075554922223091,
0.045030854642391205,
-0.006759739480912685,
0.004456444643437862,
-0.02982463501393795,
-0.027524534612894058,
-0.050704434514045715,
0.03626491501927376,
0.006018596235662699,
0.026029469445347786,
0.02380603924393654,
-0.029287945479154587,
0.05366900935769081,
0.004366996232420206,
0.004967577755451202,
0.010951033793389797,
0.010650742799043655,
0.011589949950575829,
0.00455867126584053,
-0.006318886764347553,
-0.020189769566059113,
0.006427502725273371,
0.008599819615483284,
-0.016317933797836304,
0.0008729200344532728,
-0.008267583325505257,
-0.02747342176735401,
0.011807181872427464,
0.024010492488741875,
-0.019678637385368347,
0.03376036137342453,
-0.035447102040052414,
0.0378238745033741,
0.03738940879702568,
0.06343165785074234,
-0.019793642684817314,
0.043292999267578125,
-0.021416490897536278,
-0.05044886842370033,
0.01339169591665268,
-0.00934735219925642,
0.04071177542209625,
0.011679398827254772,
-0.02356325089931488,
0.025198878720402718,
0.01962752267718315,
0.027831215411424637,
0.001269048429094255,
0.020994804799556732,
0.06598732620477676,
0.0034820963628590107,
0.006197492592036724,
-0.007954513654112816,
-0.01832413300871849,
0.03115358203649521,
0.007398656103760004,
0.03723606839776039,
-0.07171201705932617,
-0.0021787062287330627,
-0.0080120163038373,
0.006392362527549267,
0.024700522422790527,
-0.034118156880140305,
-0.022489869967103004,
0.05366900935769081,
0.009385687299072742,
0.10059105604887009,
0.03465484455227852,
-0.009372909553349018,
0.02390826679766178,
-0.043880805373191833,
-0.008127021603286266,
-0.04158070310950279,
0.03623935952782631,
-0.01667572744190693,
0.031179139390587807,
-0.0080120163038373,
0.015564012341201305,
-0.018771374598145485,
-0.013340582139790058,
0.022809328511357307,
0.038335006684064865,
-0.003954894840717316,
0.029466841369867325,
0.004836599808186293,
-0.01721241883933544,
0.057400282472372055,
-0.03140914812684059,
0.045005299150943756,
0.0421685092151165,
-0.0443919375538826,
0.010459067299962044,
-0.02709007076919079,
0.015921806916594505,
-0.010331284254789352,
0.04380413517355919,
0.014350070618093014,
-0.024777192622423172,
-0.019154725596308708,
-0.0363926999270916,
0.06787852197885513,
-0.013506700284779072,
0.006376389414072037,
-0.037312738597393036,
0.04510752484202385,
-0.04135069251060486,
-0.0178513340651989,
-0.050397757440805435,
0.03189472481608391,
-0.013762267306447029,
0.017659660428762436,
-0.007647833786904812,
-0.03667382150888443,
0.014746199361979961,
0.018720261752605438,
0.02369103394448757,
0.02455996163189411,
0.018681926652789116,
0.028291234746575356,
-0.014656750485301018,
-0.034552618861198425,
-0.013065848499536514,
0.00818452425301075,
-0.0305402223020792,
-0.01578124426305294,
0.015602347441017628,
-0.07370544224977493,
0.01512954942882061,
0.026808947324752808,
0.03956172615289688,
-0.02864902839064598,
0.007948124781250954,
-0.039791736751794815,
-0.015551234595477581,
0.048532117158174515,
0.04819988086819649,
-0.018030231818556786,
0.022221526131033897,
-0.02300100401043892,
-0.0003879422729369253,
-0.01108520571142435,
-0.01390282902866602,
0.010599629022181034,
-0.0005015496863052249,
0.050142187625169754,
-0.000193272324395366,
0.00214676046743989,
0.020189769566059113,
-0.005446765571832657,
-0.011717733927071095,
0.0011061247205361724,
-0.022732658311724663,
-0.012791113927960396,
0.05149669200181961,
0.006290135905146599,
-0.010229057632386684,
0.024342728778719902,
-0.027831215411424637,
0.04390636086463928,
-0.005175225902348757,
-0.0019311259966343641,
0.041989609599113464,
-0.013928385451436043,
-0.016190150752663612,
-0.006925858091562986,
-0.006395556963980198,
-0.005143280141055584,
-0.023678256198763847,
0.0276267621666193,
-0.008331474848091602,
0.02508387342095375,
0.04395747557282448,
0.015730131417512894,
0.04293520748615265,
0.042858537286520004,
-0.01206274889409542,
0.04610423371195793,
-0.010970201343297958,
-0.00456506060436368,
-0.05062776431441307,
0.007520050276070833,
0.018004674464464188,
-0.029850192368030548,
-0.03626491501927376,
-0.019742527976632118,
-0.031766943633556366,
-0.00402198126539588,
0.00764144491404295,
0.01587069220840931,
-0.01875859685242176,
-0.01891193725168705,
-0.002121203811839223,
0.01244609896093607,
-0.005194393452256918,
-0.010286560282111168,
-0.03749163821339607,
-0.022515427321195602,
-0.019320843741297722,
-0.017991896718740463,
0.024994423612952232,
-0.00226655718870461,
0.01241415273398161,
0.016011254861950874,
-0.019946981221437454,
-0.0200236514210701,
-0.023729369044303894,
0.019397513940930367,
-0.031792499125003815,
-0.02126315049827099,
-0.00920679047703743,
-0.008567874319851398,
0.014298957772552967,
-0.006989749614149332,
0.008280361071228981,
0.021850954741239548,
0.010906309820711613,
-0.00029869360150769353,
0.0015014543896541,
-0.025850573554635048,
0.02024088427424431,
-0.003961284179240465,
0.020624233409762383,
0.011404664255678654,
0.020253662019968033,
-0.018963050097227097,
-0.013187242671847343,
-0.04904325306415558,
-0.010037383064627647,
-0.039203934371471405,
-0.01813245750963688,
0.003242502687498927,
-0.0010246627498418093,
-0.0005882027326151729,
-0.005708721466362476,
0.0008337863837368786,
0.00775006040930748,
-0.03335145488381386,
-0.03373480588197708,
0.024841085076332092,
-0.03363258019089699,
-0.003418204840272665,
-0.011334383860230446,
-0.042705196887254715,
0.055355750024318695,
0.014490632340312004,
-0.01203080266714096,
0.012088305316865444,
0.0007579150260426104,
0.01580680161714554,
-0.010369619354605675,
-0.025288326665759087,
-0.01677795499563217,
0.04848100617527962,
-0.012401374988257885,
0.01891193725168705,
-0.03784942999482155,
-0.016662949696183205,
-0.02852124534547329,
0.009059839881956577,
0.027115628123283386,
0.007130311336368322,
0.03378592059016228,
0.0012339079985395074,
-0.01897582784295082,
0.016381826251745224,
0.04020064324140549,
-0.010273781605064869,
-0.03531932085752487,
0.019320843741297722,
0.007270873058587313,
-0.027575647458434105,
-0.03230363130569458,
-0.006657512858510017,
-0.011494113132357597,
0.019972538575530052,
0.004887713585048914,
-0.006753350142389536,
-0.0036098798736929893,
0.013136128894984722,
0.03902503848075867,
0.010216278955340385,
-0.0031338867265731096,
-0.009570972993969917,
0.03296810761094093,
0.024623852223157883,
-0.02573556825518608,
-0.013570592738687992,
0.015512899495661259,
-0.009340963326394558,
-0.026808947324752808,
-0.0060058175586164,
-0.025991134345531464,
0.026246700435876846,
0.025288326665759087,
-0.036852721124887466,
-0.020407002419233322,
0.0020908552687615156,
0.0200236514210701,
0.003871835768222809,
0.005989844910800457,
-0.022873220965266228,
0.007130311336368322,
0.010420733131468296,
-0.0033319510985165834,
-0.055202409625053406,
0.01813245750963688,
0.005715110804885626,
-0.020381445065140724,
0.01869470439851284,
0.0046768710017204285,
0.010337673127651215,
0.01702074334025383,
-0.026118917390704155,
0.0042551858350634575,
-0.0042711584828794,
-0.03115358203649521,
-0.02275821566581726,
-0.010459067299962044,
0.008286750875413418,
-0.0313069224357605,
-0.030463552102446556,
0.009947934187948704,
-0.00892566703259945,
0.008625376969575882,
-0.027396751567721367,
-0.022247081622481346,
-0.0076606119982898235,
0.032073620706796646,
0.10084662586450577,
-0.007520050276070833,
0.0251094289124012,
0.02306489646434784,
-0.021071474999189377,
0.009411243721842766,
-0.0016803510952740908,
0.016100702807307243,
-0.009775427170097828,
0.007321986369788647,
0.0016292377840727568,
0.0756477490067482,
0.026297815144062042,
0.008638154715299606,
-0.015142328105866909,
-0.027601204812526703,
-0.036290474236011505,
-0.007283651269972324,
-0.00387503020465374,
-0.01351947896182537,
0.006874744780361652,
0.009142898954451084,
-0.0022298195399343967,
-0.03506375476717949,
-0.06966748833656311,
0.010388786904513836,
0.005980261135846376,
0.025786681100726128,
0.0018736234633252025,
0.021352598443627357,
0.00026335351867601275,
-0.017225196585059166,
-0.015334002673625946,
-0.004172126762568951,
0.012350261211395264,
0.02182539738714695,
0.013148907572031021,
0.003906975965946913,
-0.015666238963603973,
-0.024381063878536224,
-0.06164269149303436,
0.015423450618982315,
0.005066609941422939,
0.03186916932463646,
0.007194202858954668,
-0.0034597343765199184,
-0.017634103074669838,
-0.02560778521001339,
-0.05072999373078346,
0.013647262006998062,
0.03800277039408684,
-0.00003526520958985202,
-0.010273781605064869,
-0.04117179661989212,
-0.03335145488381386,
0.0008673295378684998,
-0.0017011159798130393,
0.009200401604175568,
0.0021819008979946375,
-0.004858962260186672,
0.023141566663980484,
-0.021378155797719955,
0.03667382150888443,
-0.0090853963047266,
0.0037759982515126467,
0.034399278461933136,
0.057553622871637344,
-0.028189009055495262,
0.07917457073926926,
0.00029210475622676313,
-0.0051017506048083305,
0.00307638430967927,
-0.01584513671696186,
-0.02424050308763981,
-0.028342347592115402,
-0.03649492561817169,
0.010561293922364712,
-0.029006822034716606,
-0.010101274587213993,
-0.012567493133246899,
-0.010478234849870205,
0.02895570918917656,
-0.03401593118906021,
-0.04336966946721077,
0.030310211703181267,
-0.02160816639661789,
0.010503792203962803,
0.030233541503548622,
0.0070855868980288506,
-0.03841167688369751,
-0.023972157388925552,
0.01965308003127575,
0.010037383064627647,
-0.008452869020402431,
0.013251134194433689,
0.010082107037305832,
-0.043599680066108704,
0.006500978022813797,
0.001101332833059132,
-0.03475707396864891,
0.0037376631516963243,
-0.017838556319475174,
-0.00989043153822422,
0.007839509285986423,
-0.013212799094617367,
-0.0004424498765729368,
0.017276309430599213,
-0.0027681069914251566,
0.008938445709645748,
0.008050351403653622,
-0.00869565736502409,
-0.009507081471383572,
-0.017225196585059166,
0.020368667319417,
-0.003135484177619219,
-0.009475136175751686,
-0.02737119421362877,
-0.025058316066861153,
0.009590140543878078,
-0.006047347094863653,
0.015474564395844936,
0.003117913845926523,
-0.002641920931637287,
0.024572739377617836,
0.004699232988059521,
-0.018183572217822075,
-0.013251134194433689,
0.015602347441017628,
0.017902448773384094,
-0.023422688245773315,
-0.006513756699860096,
-0.014873982407152653,
0.017723551020026207,
-0.025722790509462357,
-0.006095265969634056,
-0.005366900935769081,
0.013736710883677006,
0.03174138441681862,
-0.09737091511487961,
-0.03350479528307915,
0.005219949875026941,
0.003319172654300928,
-0.031051356345415115,
0.007545607164502144,
-0.025748346000909805,
0.012746389955282211,
0.0023208651691675186,
0.0009352144552394748,
0.02824012190103531,
-0.043548569083213806,
-0.008357031270861626,
-0.031485818326473236,
-0.033223673701286316,
-0.00037097104359418154,
-0.013647262006998062,
-0.020790351554751396,
-0.003597101429477334,
0.03657159581780434,
0.007871454581618309,
0.03519153594970703,
-0.0305657796561718,
0.06639622896909714,
0.008529539220035076,
-0.0024454540107399225,
-0.011526058427989483,
-0.00818452425301075,
-0.010299338959157467,
-0.012912508100271225,
0.02415105514228344,
0.012765557505190372,
-0.01671406254172325,
0.024994423612952232,
-0.006207076366990805,
-0.039485055953264236,
0.009724313393235207,
-0.0057342778891325,
0.007667001336812973,
-0.0033287564292550087,
0.01046545710414648,
0.009104563854634762,
0.013570592738687992,
-0.0017793832812458277,
0.008095075376331806,
0.015436229296028614,
-0.03171582892537117,
0.008146189153194427,
0.009436801075935364,
-0.01958918757736683,
0.024470511823892593,
-0.029160162433981895,
-0.021684834733605385,
0.0023096841759979725,
-0.001075776177458465,
-0.028444575145840645,
-0.007986459881067276,
0.012273591011762619,
0.013353360816836357,
-0.01704629883170128,
-0.002336838049814105,
0.06327831745147705,
0.026157252490520477,
-0.01658627949655056,
0.004178515635430813,
0.0013720737770199776,
-0.048966582864522934,
0.05934258922934532,
-0.023320462554693222,
0.01475897803902626,
0.000725170539226383,
0.00017979516997002065,
-0.02334601990878582,
0.019895868375897408,
-0.01446507591754198,
0.02504553832113743,
-0.010254614055156708,
-0.011762457899749279,
0.011340772733092308,
0.000979938660748303,
-0.02139093354344368,
-0.04224517568945885,
-0.0261955875903368,
0.014605637639760971,
-0.039766181260347366,
-0.009104563854634762,
0.01987031102180481,
0.016816290095448494,
0.019665857776999474,
-0.011315216310322285,
-0.0010701855644583702,
-0.0025157348718494177,
-0.01630515605211258,
0.00844648014754057,
-0.03549821674823761,
-0.018400803208351135,
-0.0152828898280859,
-0.01869470439851284,
0.012407763861119747,
-0.022745437920093536,
0.04674315080046654,
-0.04934993386268616,
0.013001956045627594,
-0.008146189153194427,
-0.017097413539886475,
-0.02282210811972618,
0.041964054107666016,
-0.025684455409646034,
-0.004775902722030878,
-0.03319811448454857,
0.041095126420259476,
0.006465837825089693,
0.02306489646434784,
0.01569179631769657,
0.005338149610906839,
0.009213180281221867,
0.014810090884566307,
-0.02169761434197426,
0.0020908552687615156,
0.02427883818745613,
0.06971859931945801,
0.02880236878991127,
-0.004552281927317381,
-0.006357221864163876,
-0.0221959687769413,
0.004386163782328367,
0.020445337519049644,
-0.0013417252339422703,
-0.01043351087719202,
0.010395175777375698,
0.008210080675780773,
0.023857152089476585,
0.01832413300871849,
-0.01112993061542511,
-0.007436991203576326,
0.04352300986647606,
0.02563334070146084,
0.03230363130569458,
0.0064211138524115086,
0.008318696171045303,
0.009404854848980904,
-0.021493161097168922,
0.02108425460755825,
-0.01120659988373518,
0.06082487851381302,
0.015397894196212292,
-0.053055647760629654,
0.022515427321195602,
-0.010970201343297958,
0.029569068923592567,
-0.038309451192617416,
0.015103993006050587,
0.006785296369343996,
0.061744917184114456,
-0.005114528816193342,
0.03682716190814972,
-0.01353225763887167,
-0.03291699290275574,
-0.017685215920209885,
0.026732278987765312,
-0.02089257910847664,
0.051598917692899704,
-0.023576028645038605,
-0.014541746117174625,
0.019244173541665077,
-0.024623852223157883,
-0.012855005450546741,
-0.008286750875413418,
0.010663521476089954,
0.0037759982515126467,
0.010018215514719486,
-0.05499795824289322,
0.02951795607805252,
-0.00039772570016793907,
-0.018656369298696518,
-0.016049589961767197,
-0.002373575931414962,
0.016573501750826836,
0.02939017117023468,
0.002589210169389844,
-0.020164214074611664,
-0.011430221609771252,
0.002953392919152975,
0.021991515532135963,
0.03189472481608391,
-0.008503982797265053,
-0.010906309820711613,
-0.02321823500096798,
0.0363415852189064,
-0.017340201884508133,
-0.025658898055553436,
0.0019359178841114044,
0.004354218021035194,
0.05642912909388542,
0.03956172615289688,
-0.042551856487989426,
-0.020407002419233322,
0.02123759314417839,
-0.049247704446315765,
-0.020202549174427986,
-0.019576409831643105,
0.030233541503548622,
0.039203934371471405,
0.0024390649050474167,
-0.023512138053774834,
0.01969141513109207,
0.001985433977097273,
-0.04492862895131111,
0.0017713967245072126,
0.04796987026929855,
0.010088495910167694,
0.03447594866156578,
-0.04899213835597038,
0.024572739377617836,
0.010612407699227333,
-0.023614363744854927,
0.002948601031675935,
0.006651123519986868,
-0.02880236878991127,
-0.02312878705561161,
-0.03189472481608391,
-0.031664714217185974,
-0.00021902866137679666,
-0.0004963584942743182,
-0.002956587355583906,
0.0047311787493526936,
0.041989609599113464,
0.02660449407994747,
-0.019180281087756157,
0.039766181260347366,
-0.013161685317754745,
0.02169761434197426,
0.013596149161458015,
-0.015218997374176979,
-0.020176991820335388,
-0.025837793946266174,
0.003597101429477334,
-0.030335769057273865,
0.006817242130637169,
-0.023448245599865913,
0.057246942073106766,
0.02108425460755825,
0.0049324375577270985,
0.006612788885831833,
-0.011251324787735939,
0.0028304012957960367,
0.01736575737595558,
-0.03887169808149338,
0.0031259004026651382,
0.021633721888065338,
-0.00939207710325718,
0.004871740471571684,
0.028776811435818672,
0.015704574063420296,
0.04888991266489029,
0.0032137513626366854,
0.008114242926239967,
-0.0005590521614067256,
0.023524915799498558,
0.013059458695352077,
-0.01323835551738739,
0.02824012190103531,
0.009724313393235207,
-0.015436229296028614,
0.056224677711725235,
0.007865065708756447,
-0.00694502517580986,
-0.014081725850701332,
0.0029358225874602795,
0.01856692135334015,
0.007072808686643839,
0.01760854572057724,
-0.02371659129858017,
-0.00044085257104597986,
-0.013647262006998062,
-0.012624995782971382,
0.030029088258743286,
-0.0030172844417393208,
0.024789970368146896,
0.02006198652088642,
-0.015474564395844936,
-0.008497592993080616,
-0.011513280682265759,
-0.004437277093529701,
0.005909980274736881,
0.011941354721784592,
-0.045746441930532455,
-0.046334244310855865,
0.0181963499635458,
-0.020266439765691757,
-0.03493596985936165,
0.00886816531419754,
-0.01965308003127575,
0.012663330882787704,
-0.013647262006998062,
-0.014937873929738998,
-0.002041339175775647,
-0.014963431283831596,
0.02675783447921276,
0.01353225763887167,
0.02369103394448757,
0.02591446414589882,
-0.013455587439239025,
-0.03524265065789223,
0.008702046237885952,
0.004053927026689053,
-0.0023352408315986395,
-0.03319811448454857,
0.02634892798960209,
-0.01272722240537405,
-0.02663005143404007,
0.026706721633672714,
0.0005702332127839327,
-0.011091595515608788,
0.002766509773209691,
0.013123350217938423,
-0.027831215411424637,
0.01726353168487549,
0.006469032261520624,
0.03652048483490944,
0.009251515381038189,
-0.03304477408528328,
0.0006860368885099888,
0.0002559660351835191,
-0.03792610019445419,
0.016190150752663612,
0.017595767974853516,
0.004993134643882513,
0.0029581848066300154,
-0.024010492488741875,
0.034705959260463715,
-0.02073923870921135,
-0.019601967185735703,
0.029211275279521942,
-0.001113312435336411,
0.023167122155427933,
-0.013148907572031021,
0.013263911940157413,
0.00414656987413764,
-0.029032379388809204,
0.0038015549071133137,
-0.0026690748054534197,
-0.0037121064960956573,
0.002974157687276602,
0.015014544129371643,
0.010382398031651974,
-0.009583751671016216,
-0.012644163332879543,
-0.011449389159679413,
-0.014516189694404602,
0.07176313549280167,
-0.01980642043054104,
-0.03726162761449814,
0.03784942999482155,
0.0070855868980288506,
-0.007411434780806303,
0.010951033793389797,
0.035140421241521835,
-0.0007499285857193172,
0.007277261931449175,
0.005590521730482578,
0.016969630494713783,
0.014503411017358303,
-0.016599057242274284,
0.030335769057273865,
0.01069546677172184,
-0.003900586860254407,
0.004555476829409599,
0.0012706457637250423,
0.012439710088074207,
0.027703432366251945,
0.02374214679002762,
-0.03189472481608391,
-0.0028559579513967037,
-0.019819198176264763,
0.019333621487021446,
0.031766943633556366,
0.0031338867265731096,
0.01001182571053505,
0.02554389275610447,
-0.00015563613851554692,
-0.009404854848980904,
0.0004324667970649898,
-0.030029088258743286,
-0.004335050471127033,
-0.02675783447921276,
-0.04610423371195793,
-0.021442046388983727,
0.01813245750963688,
-0.007283651269972324,
-0.004280742257833481,
-0.02747342176735401,
0.01446507591754198,
-0.011583561077713966,
-0.03749163821339607,
-0.019768085330724716,
0.011545225977897644,
-0.004453249741345644,
0.010344062931835651,
0.004846183583140373,
-0.028572358191013336,
-0.011602728627622128,
0.039638396352529526,
0.0003224532993044704,
0.015052879229187965,
0.0057630292139947414,
0.0029917277861386538,
0.02340991050004959,
0.014797312207520008,
-0.0030779815278947353,
-0.01826024241745472,
-0.011187433265149593,
-0.06527173519134521,
0.027166740968823433,
-0.005009107757359743,
-0.01958918757736683,
0.013366139493882656,
0.003055619541555643,
-0.019397513940930367,
-0.02266876772046089,
0.014439519494771957,
0.002648310037329793,
-0.022873220965266228,
-0.021863732486963272,
-0.002087660599499941,
0.014235066249966621,
0.029287945479154587,
-0.00287193083204329,
-0.044161926954984665,
0.014784534461796284,
-0.0012051567900925875,
0.026374485343694687,
0.03424593806266785,
0.017352979630231857,
-0.04712650179862976,
-0.01032489538192749,
-0.013263911940157413,
0.028137894347310066,
-0.04101845622062683,
0.010714634321630001,
-0.015896249562501907,
-0.004494779743254185,
0.05131779611110687,
0.02471330016851425,
0.01624126546084881,
0.0019870311953127384,
-0.01565346121788025,
-0.017059078440070152,
0.03511486575007439,
0.001042232965119183,
0.020943691954016685,
0.03296810761094093,
-0.0349615253508091,
-0.009449578821659088,
0.005140085704624653,
-0.009769037365913391,
-0.023729369044303894,
-0.008075907826423645,
0.0012043581809848547,
0.01055490504950285,
-0.03378592059016228,
-0.005341344512999058,
0.008631765842437744,
-0.00044085257104597986,
0.002908668713644147,
-0.0006409133784472942,
-0.010401565581560135,
0.0028895011637359858,
-0.008548706769943237,
-0.0005997831467539072,
-0.0051496694795787334,
0.014567302539944649,
0.022770993411540985,
0.03626491501927376,
0.03330034390091896,
-0.04191293939948082,
0.025186099112033844,
0.021633721888065338,
-0.0015278097707778215,
0.029722409322857857,
-0.007877843454480171,
0.015014544129371643,
0.01748076267540455,
-0.007692558225244284,
0.021275928243994713,
0.03807944059371948,
-0.018094122409820557,
-0.015679018571972847,
0.050269972532987595,
0.02232375182211399,
-0.005191199015825987,
-0.00022382053430192173,
-0.013826158829033375,
0.010312116704881191,
0.0005858068470843136,
-0.013545035384595394,
-0.015385116450488567,
-0.03519153594970703,
-0.01337891723960638,
0.01046545710414648,
-0.0008234039996750653,
0.01587069220840931,
0.00021064287284389138,
-0.02523721195757389,
0.01776188611984253,
-0.0008577457629144192,
-0.04293520748615265,
-0.04715205729007721,
-0.002429481130093336,
-0.00013866490917280316,
-0.01943584904074669,
-0.015167884528636932,
-0.03041243925690651,
0.022336531430482864,
0.031485818326473236,
-0.025058316066861153,
0.010599629022181034,
0.01469508558511734,
0.0070855868980288506,
-0.0012514782138168812,
0.0037632198072969913,
0.009034283459186554,
0.026681164279580116,
-0.03593267872929573,
-0.017570210620760918,
-0.009219569154083729,
-0.011717733927071095,
0.05632690340280533,
-0.024534404277801514,
0.02282210811972618,
-0.007398656103760004,
-0.024036049842834473,
0.014017834328114986,
-0.008753160014748573,
-0.03133247792720795,
0.05249340087175369,
0.0070344735868275166,
-0.01295723207294941,
-0.027268968522548676,
-0.004370190668851137,
-0.025710010901093483,
0.029901305213570595,
0.027958998456597328,
-0.010938255116343498,
0.017928004264831543,
-0.013302247039973736,
0.03815611079335213,
-0.024355508387088776,
-0.009570972993969917,
-0.005708721466362476,
0.02021532692015171,
0.01286778412759304,
-0.037312738597393036,
-0.0038846139796078205,
0.01433729287236929,
-0.027320081368088722,
-0.013174463994801044,
0.0023432273883372545,
-0.0297990795224905,
-0.006740571931004524,
-0.0005694346036761999,
0.00024698127526789904,
-0.02012587897479534,
0.031766943633556366,
-0.003418204840272665,
0.0042711584828794,
-0.020637011155486107,
0.0057790023274719715,
-0.02523721195757389,
0.003058813977986574,
-0.009321795776486397,
-0.015883471816778183,
0.012018024921417236,
-0.0341692678630352,
-0.005219949875026941,
0.015602347441017628,
-0.007341153919696808,
0.001699518645182252,
-0.0055074626579880714,
-0.01906527765095234,
-0.02321823500096798,
-0.017378536984324455,
-0.03181805461645126,
0.0016659755492582917,
-0.021212037652730942,
-0.0385650172829628,
-0.06240938976407051,
0.007730892859399319,
0.02486664056777954,
0.00734754279255867,
-0.024099940434098244,
0.002403924474492669,
-0.0023288517259061337,
-0.005826921202242374,
0.0312558077275753,
0.015602347441017628,
-0.018426360562443733,
0.03112802468240261,
-0.025096651166677475,
0.002125995699316263,
-0.03212473541498184,
0.03363258019089699,
-0.018656369298696518,
-0.0005830115405842662,
-0.0031370813958346844,
0.007417823653668165,
-0.01956363208591938,
-0.023205457255244255,
-0.01751909777522087,
-0.006344443652778864,
-0.02558222785592079,
-0.00031306923483498394,
0.004398941993713379,
0.007852287031710148,
-0.007021695375442505,
-0.0006321282708086073,
-0.011040481738746166,
-0.006370000075548887,
0.03784942999482155,
0.042679641395807266,
0.027984555810689926,
0.04405970126390457,
-0.00640833517536521,
0.004753540735691786,
0.005628856830298901,
0.03547266125679016,
-0.014528967440128326,
-0.02895570918917656,
0.03902503848075867,
-0.017314644530415535,
-0.023767704144120216,
0.0450819693505764,
-0.00030807769508101046,
-0.022873220965266228,
-0.011200211010873318,
-0.009999047964811325,
-0.015576791018247604,
-0.0039037815295159817,
-0.018503030762076378,
0.020624233409762383,
-0.010548516176640987,
0.0032776431180536747,
-0.006938636302947998,
0.005846088752150536,
-0.02012587897479534,
0.053873464465141296,
-0.0007447373936884105,
-0.023818816989660263,
0.016688507050275803,
0.015730131417512894,
-0.030795788392424583,
0.013187242671847343,
0.013979499228298664,
0.01980642043054104,
0.033811476081609726,
0.014235066249966621,
0.010899920016527176,
0.016982408240437508,
-0.026080582290887833,
-0.015167884528636932,
-0.002926238812506199,
-0.0032329189125448465,
0.0034789019264280796,
0.03115358203649521,
0.015052879229187965,
-0.0034980694763362408,
0.010637964121997356,
0.01721241883933544,
-0.05438459664583206,
0.02824012190103531,
-0.02995241805911064,
-0.01630515605211258,
-0.03797721490263939,
0.015985697507858276,
0.11623173952102661,
-0.01204358134418726,
0.0075072720646858215,
0.020049208775162697,
0.007583942264318466,
-0.039510615170001984,
0.011219378560781479,
-0.002939017256721854,
0.010139609687030315,
-0.024253280833363533,
0.028265679255127907,
0.02130148559808731,
0.01993420347571373,
0.02489219792187214,
0.014950652606785297,
-0.01751909777522087,
0.01912916824221611,
0.027575647458434105,
0.01475897803902626,
-0.013800602406263351,
-0.015985697507858276,
0.024406621232628822,
-0.027984555810689926,
0.01943584904074669,
-0.01702074334025383,
-0.03128136694431305,
-0.009979880414903164,
-0.007015306036919355,
-0.0320480652153492,
0.01804300956428051,
0.011455778032541275,
0.02678339183330536,
-0.00044764106860384345,
-0.008235637098550797,
0.016100702807307243,
-0.018886379897594452,
-0.020573120564222336,
-0.033377014100551605,
0.02880236878991127,
-0.024547182023525238,
-0.00815257802605629,
-0.0013656846713274717,
-0.019141945987939835,
0.014235066249966621,
0.025198878720402718,
-0.010606018826365471,
-0.035728227347135544,
0.0029917277861386538,
0.02821456454694271,
-0.001718686195090413,
0.006500978022813797,
0.007877843454480171,
-0.0007651028572581708,
-0.023448245599865913,
-0.035856008529663086,
-0.023703811690211296,
0.012120251543819904,
0.012311926111578941,
-0.009615697897970676,
-0.0356004424393177,
-0.023090451955795288,
0.01244609896093607,
0.013417252339422703,
0.009015115909278393,
0.010906309820711613
] | 2024-07-13 | 38 | 38996463 | [
"patients",
"Stanford Cancer Institute",
"National Cancer Institute",
"large B-cell lymphoma",
"CAR19 therapy",
"previous therapy",
"immune effector cell-associated neurotoxicity syndrome",
"previous CAR19",
"Cancer Immunotherapy",
"CAR T-cell products",
"Parker Institute",
"CD19-negative large B-cell lymphoma",
"The identified maximum tolerated dose",
"CAR22",
"the maximum tolerated dose",
"immune effector cell-associated haemophagocytic lymphohistiocytosis-like syndrome",
"dose-limiting toxicities",
"CAR) T-cell therapy",
"refractory disease",
"National Institutes",
"pretreatment lactate dehydrogenase",
"disease progression",
"Lymphoma Society",
"adverse events",
"CAR19",
"CD22",
"a CD22-directed CAR T-cell therapy",
"Further investigations",
"CD19-directed chimeric antigen receptor",
"NCT04088890"
] | [] | 0 | 10.1016/S0140-6736(24)00746-3 | [
"Frank",
"Baird",
"Kramer",
"Srinagesh",
"Patel",
"Brown",
"Oak",
"Younes",
"Natkunam",
"Hamilton",
"Su",
"Agarwal",
"Chinnasamy",
"Egeler",
"Mavroukakis",
"Feldman",
"Sahaf",
"Mackall",
"Muffly",
"Miklos",
null
] | [
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA. Electronic address: [email protected].",
"Division of Lymphoma, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA; Cancer Center Amsterdam, Department of Hematology, Amsterdam University Medical Center, Amsterdam, Netherlands.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.",
"Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.",
"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.",
"Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.",
"Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Division of Hematology and Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA. Electronic address: [email protected].",
null
] | [
"38996463",
"34891224",
"35717989",
"30501490",
"33156925",
"36094847",
"37709204",
"36122385",
"36335261",
"30275569",
"34312556",
"32193224",
"22820658",
"29155426",
"30935953",
"33512414",
"38491306",
"36906275",
"25113753",
"32967009",
"37171597",
"33989558",
"35240681",
"32589977",
"36548927",
"37067952",
"35366963",
"36507690",
"30769193",
"33268830",
"35146579",
"33570626",
"32327504",
"32759935",
"35609867",
"35899391",
"36713414",
"32286905"
] | [] | 6.583551 | 5.328135 |
38995478 | 734 | CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy. | NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory disorders like asthma. Activating iNKT induces increasing IFN-γ, TGF-β, IL-2, and IL-10 potentially suppressing allergic asthma. However, their immunomodulatory effects, including granzyme-perforin-mediated cytotoxicity, and expression of TIM-3 and TRAIL warrant careful consideration and targeted approaches. Although CAR-T cell therapy has achieved remarkable success in treating certain cancers, its limitations necessitate exploring alternative approaches. In this context, CAR-NKT cells emerge as a promising approach for overcoming these challenges, potentially achieving safer and more effective immunotherapies. Strategies involve targeting distinct IgE-receptors and their interactions with CAR-NKT cells, potentially disrupting allergen-mast cell/basophil interactions and preventing inflammatory cytokine release. Additionally, targeting immune checkpoints like PDL-2, inducible ICOS, FASL, CTLA-4, and CD137 or dectin-1 for fungal asthma could further modulate immune responses. Furthermore, artificial intelligence and machine learning hold immense promise for revolutionizing NKT cell-based asthma therapy. AI can optimize CAR-NKT cell functionalities, design personalized treatment strategies, and unlock a future of precise and effective care. This review discusses various approaches to enhancing CAR-NKT cell efficacy and longevity, along with the challenges and opportunities they present in the treatment of allergic asthma. | [
-0.01254324708133936,
-0.013761148788034916,
0.049490053206682205,
0.023253951221704483,
-0.008696043863892555,
-0.0008764337981119752,
-0.015992071479558945,
0.03521670401096344,
-0.007113910745829344,
0.03785738721489906,
-0.009054585359990597,
0.013374151661992073,
-0.016857123002409935,
0.008087093010544777,
0.015274988487362862,
-0.03473864868283272,
-0.003104510484263301,
-0.0001672658254392445,
0.030140215530991554,
0.03073209337890148,
0.030618270859122276,
0.026110896840691566,
0.0076204207725822926,
0.004393551032990217,
-0.02729465253651142,
-0.035307761281728745,
0.006339916959404945,
-0.002700440352782607,
-0.011114773340523243,
-0.01245218887925148,
0.03523946553468704,
-0.01827990449965,
-0.036992333829402924,
-0.010278177447617054,
0.009896872565150261,
0.019862039014697075,
0.03350936248898506,
-0.001832543290220201,
-0.04122653603553772,
-0.01299853716045618,
0.06984152644872665,
-0.002731741638854146,
-0.005013884045183659,
0.05754869058728218,
-0.06378616392612457,
-0.013931882567703724,
-0.009629389271140099,
-0.003932569641619921,
0.014057086780667305,
-0.011222905479371548,
-0.01372700184583664,
0.013146506622433662,
-0.03817608952522278,
-0.00412891386076808,
-0.04857947304844856,
0.05964302644133568,
-0.028592228889465332,
0.03838096931576729,
-0.007882213220000267,
0.03202966973185539,
-0.009748903103172779,
-0.0408623032271862,
0.02488161250948906,
0.006214712280780077,
-0.07216350734233856,
-0.02383444644510746,
0.001525222440250218,
-0.006914720870554447,
-0.03373700752854347,
0.024836083874106407,
0.016640858724713326,
-0.030162980780005455,
-0.023720623925328255,
-0.0047464012168347836,
0.03045891970396042,
-0.014842462725937366,
0.015377429313957691,
0.01137087494134903,
0.020556354895234108,
-0.007557818666100502,
0.051857560873031616,
0.013123742304742336,
-0.03184755519032478,
-0.055454354733228683,
0.012873332016170025,
-0.05326896160840988,
0.00439070537686348,
-0.04596155136823654,
-0.08828078210353851,
-0.012884714640676975,
-0.04136312007904053,
-0.0193156898021698,
-0.07594241946935654,
0.03929154947400093,
-0.004504528362303972,
0.06797483563423157,
-0.026725539937615395,
-0.06160077452659607,
0.017255501821637154,
0.0321207270026207,
0.048624999821186066,
-0.01031232438981533,
-0.008690353482961655,
0.01565060392022133,
0.02465396746993065,
0.035535406321287155,
-0.029571102932095528,
0.03608175367116928,
0.0278865285217762,
0.016390450298786163,
0.03628663346171379,
0.000545636925380677,
-0.005318359471857548,
0.06688214093446732,
-0.019042516127228737,
-0.06779272109270096,
-0.05468036234378815,
0.02378891594707966,
0.008337503299117088,
0.016003452241420746,
-0.027932059019804,
0.044800564646720886,
0.050764866173267365,
0.014205056242644787,
-0.05490800738334656,
-0.04985428601503372,
0.03335001319646835,
-0.028501171618700027,
-0.07330173254013062,
-0.031437791883945465,
0.03373700752854347,
-0.01867828331887722,
0.029480045661330223,
0.006470812950283289,
-0.08354576677083969,
0.012087957002222538,
0.007261879742145538,
0.037060629576444626,
0.028068644925951958,
-0.004774856846779585,
0.008195225149393082,
-0.015935160219669342,
-0.01565060392022133,
0.0225368682295084,
-0.061919476836919785,
-0.05759422108530998,
0.013192035257816315,
0.014887992292642593,
-0.03346383571624756,
0.041545238345861435,
-0.04491438716650009,
0.0731196179986,
0.06706425547599792,
-0.015935160219669342,
-0.03264431282877922,
-0.02079538255929947,
0.004774856846779585,
0.04555179178714752,
-0.018985604867339134,
-0.038517557084560394,
-0.027135299518704414,
-0.014751404523849487,
0.024585675448179245,
-0.015195312909781933,
-0.0018183154752478004,
0.02508649416267872,
-0.008326120674610138,
0.008548075333237648,
-0.04332086816430092,
-0.025837723165750504,
-0.02039700374007225,
-0.05695681273937225,
-0.06141865625977516,
0.02230922318994999,
-0.04568837955594063,
-0.0020559201948344707,
0.01760835200548172,
0.002680521458387375,
-0.034442707896232605,
-0.008957835845649242,
-0.00378744606859982,
0.008923688903450966,
0.0016589639708399773,
-0.009817196056246758,
-0.021398643031716347,
0.002878288272768259,
-0.0279092937707901,
0.020044153556227684,
-0.06091783940792084,
0.006015522871166468,
0.01892869360744953,
0.007250497583299875,
0.021649053320288658,
0.0515388585627079,
0.006795207504183054,
-0.016037600114941597,
0.01672053523361683,
-0.010608263313770294,
-0.04407209903001785,
-0.016697769984602928,
0.04468674212694168,
-0.022275077179074287,
-0.01889454573392868,
-0.00772855244576931,
0.0214214064180851,
-0.0030134525150060654,
-0.009418817237019539,
0.028045881539583206,
-0.035558171570301056,
0.024358030408620834,
0.03394189104437828,
0.0030646726954728365,
0.0268165972083807,
0.020305946469306946,
-0.051447801291942596,
-0.006903338711708784,
0.004965509753674269,
0.05176650360226631,
0.013476592488586903,
0.02210434339940548,
-0.013806677423417568,
-0.02551901899278164,
-0.00996516551822424,
0.008986291475594044,
-0.003770372597500682,
-0.013214800506830215,
0.01952056959271431,
-0.005628526210784912,
0.023561270907521248,
-0.04095336049795151,
-0.024540144950151443,
0.01741485297679901,
0.016026217490434647,
-0.02533690445125103,
-0.04020212963223457,
-0.023766152560710907,
-0.005873244721442461,
-0.021774256601929665,
0.05135674402117729,
-0.027636120095849037,
0.016993708908557892,
0.012361130677163601,
-0.008883851580321789,
0.0033435379154980183,
-0.05713893100619316,
-0.00364516768604517,
-0.018120553344488144,
-0.058003980666399,
0.01363594364374876,
-0.01563922129571438,
0.013772530481219292,
0.011086317710578442,
0.010761924088001251,
-0.006749678403139114,
-0.024790555238723755,
0.00976597610861063,
0.05276814103126526,
-0.02597431093454361,
-0.0066870758309960365,
0.002192507265135646,
0.0004730750515591353,
-0.030618270859122276,
-0.02765888348221779,
-0.05254049599170685,
-0.04653066769242287,
-0.006778134033083916,
-0.024745026603341103,
0.011092009022831917,
0.026975948363542557,
-0.03002639301121235,
0.03278090059757233,
-0.009088732302188873,
0.0055403136648237705,
-0.0750773623585701,
-0.014398555271327496,
0.0450737364590168,
0.02063603140413761,
0.01670915260910988,
-0.002647797577083111,
0.013692854903638363,
-0.02300354093313217,
-0.029138578101992607,
0.03578581660985947,
-0.06606262177228928,
-0.019031133502721786,
-0.031893081963062286,
0.012873332016170025,
-0.022798661142587662,
-0.007051308173686266,
-0.05217626690864563,
0.020988881587982178,
-0.04785100743174553,
-0.017551440745592117,
0.00030945512116886675,
0.0011681041214615107,
0.004370786715298891,
-0.0322345495223999,
0.009794431738555431,
-0.01267983391880989,
0.007284644525498152,
-0.02809141017496586,
-0.0016646550502628088,
-0.014865227043628693,
-0.05672916769981384,
0.01736932434141636,
0.011524534784257412,
-0.018154699355363846,
0.0004552902828436345,
0.05622834712266922,
0.028637757524847984,
0.015013196505606174,
0.01040338259190321,
0.010198501870036125,
0.02235475182533264,
-0.012247308157384396,
-0.0022693374194204807,
0.02615642547607422,
-0.05987067148089409,
0.029457280412316322,
-0.013032684102654457,
-0.03674192354083061,
-0.01417090930044651,
-0.01114892028272152,
0.009629389271140099,
0.03348660096526146,
-0.028068644925951958,
0.005403726361691952,
-0.017096150666475296,
0.01735794171690941,
-0.009805814363062382,
-0.013567649759352207,
-0.009982239454984665,
0.03687851130962372,
0.010864363983273506,
0.014671728946268559,
-0.004262655042111874,
-0.03462482616305351,
-0.07016023248434067,
0.004214280750602484,
-0.0008814135217107832,
-0.011626975610852242,
0.02724912203848362,
-0.03603622689843178,
0.026748303323984146,
-0.00031941456836648285,
0.021353114396333694,
0.0005139800487086177,
0.0046610343270003796,
0.0172099731862545,
0.0537242516875267,
0.02492714300751686,
0.030003629624843597,
-0.014740022830665112,
-0.010574116371572018,
-0.01071070320904255,
0.0032012597657740116,
0.011524534784257412,
-0.02492714300751686,
0.000741269497666508,
-0.013783913105726242,
-0.00944727286696434,
-0.008587912656366825,
-0.035967931151390076,
0.06141865625977516,
0.029457280412316322,
0.019042516127228737,
-0.02529137395322323,
0.004968354944139719,
-0.05823162570595741,
-0.05381530895829201,
0.008667588233947754,
-0.021102704107761383,
0.04445909336209297,
0.007210659794509411,
-0.016891269013285637,
0.04145418107509613,
0.04247858375310898,
0.011444859206676483,
0.01952056959271431,
-0.0038358205929398537,
0.01631077378988266,
0.02019212394952774,
0.012486335821449757,
-0.04548349976539612,
-0.009606624953448772,
0.022684838622808456,
0.015753043815493584,
-0.041340358555316925,
-0.07598794996738434,
0.0536787249147892,
0.022036049515008926,
-0.050946980714797974,
0.0005804951069876552,
-0.02809141017496586,
-0.0033833759371191263,
0.03068656474351883,
-0.04441356658935547,
0.048852644860744476,
0.05308684706687927,
0.04061189293861389,
-0.010164354927837849,
0.013715619221329689,
-0.019281543791294098,
0.005383807700127363,
0.040293190628290176,
-0.047122541815042496,
0.024790555238723755,
0.012429424561560154,
0.03922325745224953,
-0.04245581850409508,
-0.004786239005625248,
0.0012904633767902851,
0.024836083874106407,
0.01566198468208313,
0.006783824879676104,
-0.025405196473002434,
-0.03995172306895256,
0.06601709127426147,
-0.00848547276109457,
0.008718809112906456,
-0.013123742304742336,
-0.02126205526292324,
0.033372778445482254,
-0.07029681652784348,
0.01009606197476387,
0.02813693881034851,
0.024813320487737656,
-0.024426322430372238,
-0.019440894946455956,
-0.051629915833473206,
-0.021182380616664886,
0.07266432791948318,
-0.013829441741108894,
-0.015536780469119549,
-0.03419230133295059,
0.03751591965556145,
-0.050127457827329636,
0.03496629372239113,
-0.007580582983791828,
0.018792105838656425,
-0.004202898126095533,
-0.0007334441761486232,
-0.014648964628577232,
0.004123222548514605,
0.02015797607600689,
0.034488238394260406,
-0.013920499943196774,
0.0056683639995753765,
-0.025268610566854477,
-0.005329741630703211,
-0.03068656474351883,
-0.02877434529364109,
0.020988881587982178,
0.008940762840211391,
0.008200916461646557,
-0.024972671642899513,
0.048169709742069244,
-0.04844288527965546,
0.023675093427300453,
0.038107797503471375,
0.05003640055656433,
-0.051174625754356384,
0.004743555560708046,
-0.0010557043133303523,
-0.05126568302512169,
0.03234837204217911,
0.010670865885913372,
-0.011257052421569824,
0.011928604915738106,
-0.035080116242170334,
-0.006465122103691101,
-0.032484959810972214,
-0.024107620120048523,
-0.008627750910818577,
-0.024403559044003487,
0.04609813913702965,
0.0343061238527298,
0.008548075333237648,
-0.0385858491063118,
0.03091420978307724,
-0.018416492268443108,
0.016822975128889084,
-0.024790555238723755,
-0.016401832923293114,
0.06679107993841171,
0.02103441022336483,
-0.0004382168990559876,
0.018712429329752922,
0.015115637332201004,
0.013840824365615845,
-0.01631077378988266,
0.012702598236501217,
0.04181841015815735,
-0.008929380215704441,
-0.014853845350444317,
-0.019679922610521317,
0.01675468124449253,
0.003263862105086446,
-0.0408623032271862,
0.005534622352570295,
-0.004900061525404453,
0.007751316763460636,
-0.002721782075241208,
0.02706700749695301,
0.039837900549173355,
0.01756282150745392,
0.031050795689225197,
0.03544434905052185,
-0.02315150946378708,
0.036787454038858414,
-0.07544159889221191,
0.022684838622808456,
0.026566186919808388,
-0.013590415008366108,
-0.022593779489398003,
-0.01512701902538538,
-0.03048168309032917,
-0.013487974181771278,
-0.028455642983317375,
-0.0019335608230903745,
0.007700096815824509,
-0.01952056959271431,
-0.039382606744766235,
0.014034322462975979,
0.02449461631476879,
-0.03471588343381882,
-0.029502809047698975,
-0.024153148755431175,
-0.020146595314145088,
-0.03803950175642967,
0.03931431472301483,
-0.015195312909781933,
0.006914720870554447,
0.0535876639187336,
-0.043457455933094025,
-0.034875236451625824,
-0.005896009039133787,
-0.00171587523072958,
-0.021102704107761383,
-0.015616456046700478,
0.028910933062434196,
-0.004954127129167318,
0.00976597610861063,
0.008991982787847519,
-0.007159439381211996,
0.018598606809973717,
0.004837458953261375,
-0.0008742996142245829,
-0.014694493263959885,
0.017756320536136627,
0.03601346164941788,
-0.02337915636599064,
0.021944990381598473,
0.003579719690605998,
0.005295595154166222,
-0.029138578101992607,
0.002109985798597336,
-0.026771068572998047,
-0.00729033537209034,
0.014751404523849487,
-0.016811592504382133,
-0.01567336730659008,
-0.0040236278437078,
-0.02229784056544304,
-0.0020160821732133627,
-0.020727090537548065,
0.016993708908557892,
-0.011456241831183434,
-0.022195400670170784,
0.057184457778930664,
-0.00018780723621603101,
-0.023697858676314354,
-0.0006036153063178062,
-0.027203593403100967,
0.046439606696367264,
-0.019144956022500992,
-0.004478917922824621,
0.014387172646820545,
-0.012258690781891346,
0.009213936515152454,
-0.038107797503471375,
-0.0013793872203677893,
-0.018348198384046555,
0.025928780436515808,
-0.014125380665063858,
0.009065967984497547,
-0.026998713612556458,
-0.055864118039608,
0.0012477799318730831,
-0.009999312460422516,
0.026998713612556458,
-0.012953008525073528,
0.03801673650741577,
-0.005392344202846289,
-0.056137289851903915,
-0.00009141374903265387,
-0.01480831578373909,
-0.006920412182807922,
-0.011541608721017838,
-0.001503880717791617,
0.029275164008140564,
-0.029275164008140564,
-0.032735370099544525,
-0.04190947115421295,
-0.027840999886393547,
0.0024500307627022266,
-0.0006366950110532343,
0.011644048616290092,
0.026930419728159904,
0.006692767143249512,
0.030868681147694588,
0.037493154406547546,
0.006476504262536764,
-0.015821337699890137,
-0.003730534575879574,
-0.012816420756280422,
-0.02422144263982773,
0.013169270940124989,
0.0001690443023107946,
-0.02276451326906681,
-0.022172635421156883,
-0.03922325745224953,
-0.024426322430372238,
0.0160945113748312,
-0.023026306182146072,
-0.06410486996173859,
-0.011313963681459427,
-0.0020687251817435026,
0.009452964179217815,
-0.01052289642393589,
0.0144896125420928,
-0.017448998987674713,
-0.013658707961440086,
0.04958111047744751,
-0.02422144263982773,
-0.06132759898900986,
0.05927879363298416,
-0.005762267392128706,
-0.0005168255884200335,
-0.0005484825232997537,
-0.032302845269441605,
0.01053427904844284,
0.02515478804707527,
0.00828628335148096,
0.01223592646420002,
0.008013108745217323,
-0.05276814103126526,
-0.0034545150119811296,
0.012019663117825985,
-0.0015735969645902514,
-0.019588863477110863,
-0.03815332427620888,
0.007261879742145538,
-0.007506598252803087,
0.007830992341041565,
-0.012748127803206444,
0.024175914004445076,
-0.010226957499980927,
0.05331449210643768,
0.03990619257092476,
-0.03330448269844055,
-0.015616456046700478,
-0.021444171667099,
0.011194449849426746,
0.0033805302809923887,
-0.00022284324222709984,
0.019042516127228737,
0.009925328195095062,
0.019019750878214836,
-0.009293613024055958,
0.06565285474061966,
0.03715168684720993,
-0.005079332273453474,
-0.01168957818299532,
-0.00009968366794055328,
0.03330448269844055,
0.01158713735640049,
-0.016891269013285637,
0.00030660955235362053,
0.006402519531548023,
-0.006721222773194313,
0.0022807198110967875,
-0.03815332427620888,
-0.035489875823259354,
0.016857123002409935,
-0.010061915032565594,
0.05695681273937225,
-0.010608263313770294,
-0.013522121123969555,
-0.014341644011437893,
0.005565923638641834,
-0.02704424224793911,
-0.04377615824341774,
0.004461844451725483,
0.009481419809162617,
0.05167544633150101,
-0.007876521907746792,
0.0006356278900057077,
-0.020089684054255486,
-0.017448998987674713,
-0.00569397397339344,
0.024426322430372238,
-0.027749942615628242,
-0.012793656438589096,
0.017301030457019806,
-0.009714756160974503,
0.00292239454574883,
-0.01190584059804678,
0.031187383458018303,
0.012975772842764854,
-0.011382256634533405,
-0.02424420788884163,
0.00806432869285345,
-0.009344832971692085,
-0.02424420788884163,
-0.01760835200548172,
0.017722174525260925,
0.049672167748212814,
0.010818835347890854,
0.013226182200014591,
-0.019896185025572777,
0.03371424600481987,
0.028023116290569305,
0.018177464604377747,
0.03760697692632675,
0.00709114596247673,
-0.028706051409244537,
0.023310862481594086,
0.011513153091073036,
-0.006243167910724878,
-0.01993033103644848,
-0.053360018879175186,
-0.0069261034950613976,
-0.008070020005106926,
-0.05194862186908722,
0.0267938319593668,
-0.017642498016357422,
-0.03970131278038025,
-0.0029992247000336647,
0.00440493319183588,
0.008434251882135868,
-0.055955175310373306,
-0.029935335740447044,
0.025427961722016335,
0.0017912826733663678,
0.00220246659591794,
-0.0005278521566651762,
-0.0032268697395920753,
0.02294662967324257,
-0.02877434529364109,
-0.0039837900549173355,
0.007335864473134279,
-0.0023049069568514824,
0.0017059157835319638,
-0.014113998040556908,
-0.0134196812286973,
-0.003576874267309904,
-0.028910933062434196,
-0.02275313064455986,
-0.021740110591053963,
-0.020010007545351982,
-0.001482538995333016,
0.03305407240986824,
-0.0005371002480387688,
0.018985604867339134,
0.005534622352570295,
0.003713461337611079,
0.04637131467461586,
0.017323795706033707,
0.03687851130962372,
-0.02727188728749752,
-0.038995612412691116,
-0.018188847228884697,
-0.01717582531273365,
0.000471652252599597,
-0.0013423949712887406,
-0.0031756495591253042,
-0.020317329093813896,
0.0365370437502861,
0.036787454038858414,
0.014705875888466835,
-0.012873332016170025,
0.0006811569328419864,
-0.03496629372239113,
0.019258778542280197,
0.0066870758309960365,
-0.022593779489398003,
-0.002299215877428651,
0.002731741638854146,
-0.020237652584910393,
-0.008946454152464867,
0.061509717255830765,
-0.0023219804279506207,
0.0035057351924479008,
-0.03567199409008026,
0.033987417817115784,
-0.007102528121322393,
-0.07598794996738434,
-0.034442707896232605,
-0.01654980145394802,
0.012258690781891346,
-0.0007924896199256182,
0.006789516191929579,
-0.034488238394260406,
0.004860223736613989,
0.0008871046593412757,
-0.008821249008178711,
0.016800211742520332,
0.013533503748476505,
0.004589895252138376,
-0.010483058169484138,
0.0060951984487473965,
-0.010784688405692577,
-0.0038472027517855167,
-0.046894896775484085,
-0.016675006598234177,
0.029889807105064392,
0.010335089638829231,
-0.014466848224401474,
-0.030777622014284134,
0.057229988276958466,
-0.030390625819563866,
-0.0054293363355100155,
0.013783913105726242,
-0.0015664830571040511,
-0.012509100139141083,
-0.00017242340254597366,
-0.022866953164339066,
-0.02831905521452427,
-0.027385709807276726,
0.020909205079078674,
-0.0048630693927407265,
0.0037675269413739443,
0.024107620120048523,
-0.00396387092769146,
-0.014011558145284653,
-0.027112536132335663,
-0.003229715395718813,
0.03476141393184662,
0.0013125165132805705,
-0.006988705601543188,
-0.03492076322436333,
-0.04826077073812485,
0.011780635453760624,
0.002987842308357358,
0.02426697127521038,
0.002380314515903592,
0.037242744117975235,
-0.03066379949450493,
-0.04698595777153969,
-0.027840999886393547,
0.008980601094663143,
0.019383983686566353,
-0.03908666968345642,
0.052950259298086166,
-0.007529363036155701,
0.03951919451355934,
-0.033600423485040665,
0.012850567698478699,
0.03070932812988758,
0.01544572226703167,
-0.012361130677163601,
-0.01331724040210247,
-0.010460293851792812,
0.004587049596011639,
-0.017084768041968346,
-0.026975948363542557,
-0.02963939681649208,
0.021808404475450516,
-0.0407712422311306,
0.00967491790652275,
0.010420456528663635,
-0.0028967843391001225,
-0.021330349147319794,
0.0036053298972547054,
-0.01083021704107523,
0.04684937000274658,
-0.019918950274586678,
-0.00806432869285345,
0.003346383571624756,
-0.011444859206676483,
0.03093697316944599,
0.002605114132165909,
0.033987417817115784,
0.02127343788743019,
-0.02316289208829403,
-0.016390450298786163,
0.015422957949340343,
-0.016356302425265312,
-0.009276539087295532,
-0.015263606794178486,
-0.01267983391880989,
0.010682247579097748,
-0.005193154793232679,
0.024995436891913414,
0.011120464652776718,
-0.015502633526921272,
0.036582574248313904,
-0.0038102103862911463,
-0.058049511164426804,
-0.007540745195001364,
-0.014694493263959885,
0.004052083473652601,
0.017779085785150528,
0.02214987203478813,
0.003241097554564476,
0.017460381612181664,
0.05340554937720299,
-0.008872468955814838,
0.005884626880288124,
0.019611628726124763,
-0.0033719935454428196,
0.0024301118683069944,
0.03066379949450493,
0.00028455641586333513,
-0.00686350092291832,
0.015092872083187103,
0.07143504172563553,
-0.012190396897494793,
-0.01693679764866829,
0.01714167930185795,
0.015980688855051994,
-0.00012049185897922143,
-0.0013587569119408727,
0.009896872565150261,
-0.007586274296045303,
-0.0020374238956719637,
-0.01364732626825571,
-0.027362944558262825,
0.02105717547237873,
-0.010739159770309925,
-0.016253862529993057,
0.009390361607074738,
0.0515843890607357,
0.0321207270026207,
0.015411575324833393,
0.028933696448802948,
0.019623011350631714,
0.0024599903263151646,
-0.030094686895608902,
-0.014512377791106701,
0.028614994138479233,
0.014113998040556908,
-0.03387359529733658,
0.023561270907521248,
0.02829628996551037,
0.017961202189326286,
0.004532983992248774,
0.012110721319913864,
0.04188670590519905,
0.053769782185554504,
-0.007853757590055466,
0.015741661190986633,
0.016242479905486107,
0.0021412870846688747,
-0.03826714679598808,
0.03717445209622383,
-0.017118914052844048,
0.010477367788553238,
-0.00849116314202547,
-0.0023120208643376827,
0.0017713636625558138,
0.011285508051514626,
-0.02104579284787178,
-0.004248427227139473,
0.03514840826392174,
0.016857123002409935,
-0.028205232694745064,
-0.02920687012374401,
0.028250761330127716,
0.003801673883572221,
-0.0010165778221562505,
-0.023902738466858864,
0.019281543791294098,
0.017505910247564316,
0.03369148075580597,
0.05003640055656433,
-0.02403932623565197,
0.011473314836621284,
0.012691216543316841,
0.0064195930026471615,
0.035694755613803864,
-0.04229646548628807,
-0.008997674100100994,
-0.0025282837450504303,
0.012429424561560154,
0.026520658284425735,
-0.011461932212114334,
-0.030185744166374207,
0.029958099126815796,
0.036400455981492996,
-0.02214987203478813,
-0.01974821649491787,
0.013237564824521542,
0.014250585809350014,
-0.03305407240986824,
0.010773305781185627,
-0.012930244207382202,
0.0215010829269886,
0.03963301703333855,
-0.022889718413352966,
-0.016595330089330673,
0.009931019507348537,
0.003502889536321163,
-0.03995172306895256,
-0.02360680140554905,
0.03603622689843178,
0.014011558145284653,
0.046257492154836655,
-0.01735794171690941,
-0.01222454383969307,
0.0008145427564159036,
0.03473864868283272,
-0.019884802401065826,
-0.03004915826022625,
-0.04040701314806938,
-0.014125380665063858,
-0.039815135300159454,
-0.028227996081113815,
-0.0048744515515863895,
0.010005003772675991,
-0.025040965527296066,
0.026019839569926262,
0.020044153556227684,
0.031255677342414856,
0.0031500395853072405,
0.014330261386930943,
-0.03460206091403961,
0.0386541448533535,
0.010016386397182941,
-0.001461197272874415,
0.019793745130300522,
0.020010007545351982,
-0.01104078907519579,
-0.007250497583299875,
0.017312413081526756,
0.015422957949340343,
0.021136850118637085,
0.022707602009177208,
-0.02533690445125103,
-0.03373700752854347,
0.000359963858500123,
-0.00548055674880743,
0.04423144832253456,
0.02166043408215046,
-0.030982503667473793,
-0.016891269013285637,
-0.0058504799380898476,
-0.016595330089330673,
0.03139226511120796,
0.03127844259142876,
0.012691216543316841,
0.010164354927837849,
0.021842550486326218,
0.013431062921881676,
0.024175914004445076,
0.011126155965030193,
0.031870320439338684,
0.0028839793521910906,
-0.031232912093400955,
-0.027158064767718315,
0.0018780723912641406,
-0.0021512466482818127,
-0.018370961770415306,
-0.017084768041968346,
0.05481695011258125,
0.01845063827931881,
-0.0017955510411411524,
0.01104078907519579,
-0.001338126603513956,
0.005608607083559036,
0.016629477962851524,
0.0018923002062365413,
0.010676557198166847,
-0.02704424224793911,
0.002848409814760089,
-0.007432613521814346,
0.006408210378140211,
-0.011393639259040356,
-0.031870320439338684,
0.01672053523361683,
0.02811417356133461,
-0.006209020968526602,
-0.010477367788553238,
-0.005389498546719551,
0.022866953164339066,
-0.00827490072697401,
-0.013260329142212868,
0.014011558145284653,
-0.021626288071274757,
0.0006580367335118353,
-0.006339916959404945,
-0.014865227043628693,
0.013146506622433662,
0.0024500307627022266,
0.00944158248603344,
-0.028273526579141617,
0.010528587736189365,
0.00461550522595644,
-0.019600246101617813,
0.034032948315143585,
0.021808404475450516,
0.028387349098920822,
-0.019019750878214836,
-0.040429774671792984,
0.046894896775484085,
0.004561439622193575,
-0.04443633183836937,
-0.008525310084223747,
0.011735106818377972,
-0.02342468500137329,
0.030845915898680687,
0.01084159966558218,
-0.02444908767938614,
0.013670090585947037,
0.011626975610852242,
-0.003855739487335086,
-0.007284644525498152,
-0.006613091100007296,
0.01868966594338417,
-0.006692767143249512,
-0.015980688855051994,
-0.010926966555416584,
0.01634492166340351,
-0.017517292872071266,
-0.002659179735928774,
0.005235838238149881,
0.007506598252803087,
0.0016973790479823947,
0.020727090537548065,
-0.003241097554564476,
0.015992071479558945,
0.02191084437072277,
0.0018965685740113258,
0.010255413129925728,
-0.014307497069239616,
0.017688026651740074,
-0.06264793872833252,
0.008718809112906456,
0.020249035209417343,
0.018814871087670326,
0.011251361109316349,
-0.019668539986014366,
-0.01950918883085251,
0.0171872079372406,
-0.023128746077418327,
-0.024084854871034622,
0.052904728800058365,
-0.00204169237986207,
-0.027362944558262825,
0.029366223141551018,
-0.0026919038500636816,
-0.006795207504183054,
0.044959913939237595,
-0.00009879442950477824,
-0.011109082959592342,
0.021956373006105423,
0.006829353980720043,
0.01846202090382576,
0.02729465253651142,
-0.029889807105064392,
-0.009845651686191559,
0.027112536132335663,
-0.041954997926950455,
-0.01041476521641016,
-0.005992758087813854,
-0.01489937398582697,
0.003315082285553217,
0.023242568597197533,
-0.026725539937615395,
-0.002273605903610587,
0.02704424224793911,
0.00498258275911212,
0.031893081963062286,
0.030413391068577766,
-0.009065967984497547,
0.017904289066791534,
-0.0033862213604152203,
-0.020101064816117287,
-0.024972671642899513,
0.001380810048431158,
0.008730190806090832,
-0.017039237543940544,
-0.019053898751735687,
-0.014637582004070282,
-0.004126068204641342,
0.018393727019429207,
0.030162980780005455,
0.0019292925717309117,
0.0033833759371191263,
0.018370961770415306,
-0.0075350538827478886,
-0.012987155467271805,
0.004248427227139473,
0.011433476582169533,
-0.012520482763648033,
0.004809003323316574,
-0.03141503036022186,
-0.008764337748289108,
0.031232912093400955,
-0.01458067074418068,
-0.016822975128889084,
-0.009953783825039864,
0.013772530481219292,
0.015195312909781933,
-0.006510650739073753,
0.008229372091591358,
-0.01996447890996933,
0.0023475904017686844,
-0.062147121876478195,
-0.0042512728832662106,
-0.009919636882841587,
0.006396828219294548,
-0.005324050784111023,
0.005779340863227844,
-0.01588962972164154,
0.008639132604002953,
-0.011700959876179695,
0.0022110033314675093,
0.021603522822260857,
-0.017232736572623253,
-0.012281455099582672,
0.0386541448533535,
-0.0028555237222462893,
0.0002635703713167459,
-0.004737864248454571,
0.030549976974725723,
-0.003961025271564722,
-0.013453827239573002,
0.023105980828404427,
-0.009982239454984665,
-0.015286371111869812,
0.022491339594125748,
-0.011951369233429432,
0.005722429603338242,
-0.010437529534101486,
0.008115549571812153,
-0.015377429313957691,
-0.010824526660144329,
0.01536604668945074,
0.018609989434480667,
0.007318791002035141,
-0.021398643031716347,
0.004865914583206177,
-0.008883851580321789,
-0.017266884446144104,
0.012179015204310417,
0.026497893035411835,
0.018131935968995094,
-0.020886441692709923,
-0.0036764689721167088,
-0.02191084437072277,
0.030322331935167313,
-0.031028032302856445,
0.01117737591266632,
0.0069431765004992485,
0.03717445209622383,
-0.02665724605321884,
0.013362769968807697,
-0.0015707514248788357,
-0.0036679322365671396,
-0.014683111570775509,
0.001078468863852322,
-0.011205831542611122,
-0.004066311288625002,
-0.023299479857087135,
0.0034146769903600216,
0.015183930285274982,
0.0006345608271658421,
0.01805225946009159,
-0.011023716069757938,
0.004328103270381689,
-0.025837723165750504,
0.042205408215522766,
-0.001865267287939787,
-0.01676606386899948,
-0.012087957002222538,
-0.023265333846211433,
0.040247660130262375,
-0.043889980763196945,
0.026543423533439636,
-0.0013907694956287742,
0.024562910199165344,
0.011211522854864597,
-0.05044616386294365,
0.017676644027233124,
-0.01149607915431261,
0.010670865885913372,
0.00828628335148096,
-0.02895646169781685,
-0.029138578101992607,
0.007757008075714111,
-0.013590415008366108,
0.0002601912710815668,
-0.00206445693038404,
0.015400193631649017,
0.0076204207725822926,
0.02015797607600689,
0.0036366309504956007,
-0.012361130677163601,
0.0004225662851240486,
-0.0036508587654680014,
-0.002169742714613676,
-0.03621834143996239,
-0.07744487375020981,
-0.016629477962851524,
0.018575843423604965,
-0.0321890227496624,
-0.006635855883359909,
-0.02620195597410202,
-0.005452101118862629,
0.0536787249147892,
-0.03694680705666542,
0.015787189826369286,
0.05431612953543663,
0.009817196056246758,
0.038790732622146606,
-0.01085298229008913,
0.011000950820744038,
-0.023766152560710907,
-0.023720623925328255,
-0.010335089638829231,
0.004017936531454325,
-0.02059050276875496,
0.016356302425265312,
-0.020078301429748535,
0.021649053320288658,
0.0171872079372406,
-0.01757420413196087,
0.012087957002222538,
-0.015514016151428223,
-0.023948268964886665,
-0.004860223736613989,
-0.013670090585947037,
-0.01906527951359749,
-0.006305770482867956,
-0.019805127754807472,
-0.023971032351255417,
-0.013840824365615845,
0.014341644011437893,
0.007637494243681431,
0.021205144003033638,
0.0011972711654379964,
0.03890455514192581,
0.0021512466482818127,
0.017096150666475296,
0.02510925941169262,
0.034055713564157486,
-0.01308959536254406,
-0.014318878762423992,
-0.022878335788846016,
0.007210659794509411,
-0.0034886617213487625,
0.0066017089411616325,
0.028501171618700027,
-0.01278227474540472,
0.020954735577106476,
-0.01213348563760519,
-0.005113478749990463,
0.007296026684343815,
0.05509012192487717,
0.004652497358620167,
-0.01051151379942894,
0.0037846004124730825,
-0.03259878233075142,
-0.054179541766643524,
-0.03801673650741577,
-0.020066918805241585,
-0.017551440745592117,
-0.015331899747252464,
-0.0005207382491789758,
-0.02210434339940548,
0.010181428864598274,
-0.012281455099582672,
0.018564460799098015,
-0.02727188728749752,
-0.00966922752559185,
-0.01028386875987053,
0.0052586025558412075,
0.018985604867339134,
-0.0030732094310224056,
-0.03696956858038902,
-0.007387084886431694,
0.0072675710543990135,
0.008690353482961655,
0.0032240243162959814,
-0.007375702261924744,
-0.05759422108530998,
0.013670090585947037,
0.03070932812988758,
-0.02941175177693367,
0.016037600114941597,
0.03485247120261192,
0.01697094552218914,
0.02257101610302925,
-0.04063465818762779,
-0.003588256426155567,
-0.015297752805054188,
0.011296889744699001,
0.009834269993007183,
-0.009999312460422516,
-0.008866777643561363,
-0.033987417817115784,
-0.005440718960016966,
-0.01740347035229206,
-0.008371650241315365,
0.0013637366937473416,
-0.025906017050147057,
0.03307683765888214,
0.0002822444075718522,
0.02529137395322323,
-0.031096326187253,
0.0155481630936265,
-0.008149695582687855,
0.0029252399690449238,
-0.007261879742145538,
0.0024158840533345938,
0.03205243498086929,
0.03526223078370094,
-0.018996987491846085,
-0.001048590405844152,
0.039837900549173355,
-0.004424852319061756,
-0.005878935568034649,
0.007893594913184643,
0.002563853282481432,
-0.010978186503052711,
-0.024790555238723755,
0.03321342542767525,
0.03332724794745445,
-0.03785738721489906,
-0.014307497069239616,
-0.003909805323928595,
-0.014865227043628693,
0.01650427281856537,
-0.04985428601503372,
-0.013852206990122795,
-0.03073209337890148,
0.0034289048053324223,
0.009094423614442348,
0.009487111121416092,
-0.053951896727085114,
0.007865139283239841,
-0.001280503929592669,
0.01104078907519579,
0.03264431282877922,
0.0025809267535805702,
-0.0026093823835253716,
0.017938436940312386,
-0.015422957949340343,
0.029707690700888634,
0.02188807912170887,
0.01977097988128662,
-0.005178926978260279,
0.029275164008140564,
-0.02020350657403469,
0.01631077378988266,
0.03906390443444252,
-0.007631803397089243,
0.007000087760388851,
0.014022940769791603,
0.0027047088369727135,
0.014512377791106701,
0.023231185972690582,
0.030071921646595,
-0.02277589589357376,
0.007432613521814346,
0.0003670777950901538,
0.03690127655863762,
0.008872468955814838,
-0.05017298832535744,
0.08354576677083969,
-0.023470213636755943,
0.016048982739448547,
0.012418041937053204,
-0.03587687388062477,
0.012850567698478699,
0.05026404559612274,
-0.0034061402548104525,
0.011780635453760624,
-0.03155161440372467,
0.009492802433669567,
-0.0006050380761735141,
0.0268165972083807,
0.011883076280355453,
0.03792567923665047,
-0.023231185972690582,
-0.018974222242832184,
0.016470124945044518,
0.0030248346738517284,
-0.005913082510232925,
0.005600070580840111,
0.03883625939488411,
-0.015104254707694054,
-0.003482970641925931,
-0.03671916201710701,
0.008616368286311626,
0.01779046654701233,
0.0035228084307163954,
0.016037600114941597,
-0.04140865057706833,
0.020283181220293045,
0.028023116290569305,
0.028819873929023743,
-0.026907654479146004,
-0.02293524704873562,
-0.03544434905052185,
-0.023219803348183632,
-0.005969993770122528,
0.018291287124156952,
0.034419946372509,
0.0054549467749893665,
0.013112359680235386,
-0.01191722322255373,
0.018166081979870796,
0.010300942696630955,
0.016652241349220276,
-0.02729465253651142,
0.023993797600269318,
0.018291287124156952,
0.00745537830516696,
-0.027362944558262825,
0.00777408154681325,
0.0267938319593668,
-0.011473314836621284,
-0.008855395950376987,
-0.03419230133295059,
0.019361218437552452,
-0.0004944168031215668,
-0.005947228986769915,
-0.008001726120710373,
0.024562910199165344,
0.014557906426489353,
0.018291287124156952,
-0.021307583898305893,
0.0017500219400972128
] | 2024-07-12 | 302 | 38995478 | [
"NKT cells",
"NKT",
"targeted approaches",
"NKT cell-based asthma therapy",
"allergic asthma",
"CAR-NKT cell functionalities",
"CAR-NKT cell efficacy",
"fungal asthma",
"CAR-NKT cells",
"design personalized treatment strategies",
"various approaches",
"alternative approaches",
"asthma",
"inflammatory cytokine release",
"CAR-T cell therapy",
"inflammatory disorders",
"immune checkpoints",
"machine learning",
"inducible ICOS",
"certain cancers",
"significant potential",
"immense promise",
"remarkable success",
"immune responses",
"careful consideration",
"allergen-mast cell/basophil interactions",
"Strategies",
"artificial intelligence",
"IFN",
"expression"
] | [
"Adoptive cellular therapy",
"Airway hyperreactivity",
"Allergy",
"Artificial intelligence",
"Chimeric antigen receptors"
] | 0 | 10.1007/s12016-024-08998-0
10.1016/S0140-6736(17)32154-2
10.1016/S2213-2600(20)30105-3
10.1038/nm.2678
10.1007/s10753-021-01466-3
10.3389/fimmu.2021.786238
10.1016/S0140-6736(06)69290-8
10.1016/j.jaci.2021.12.765
10.1183/09031936.00202013
10.1164/rccm.201810-1868CI
10.1016/S0091-6749(98)70268-4
10.1186/s40733-016-0029-3
10.1126/sciadv.adi3770
10.3389/fimmu.2017.01125
10.1126/scitranslmed.aaa3643
10.1186/s40364-023-00482-9
10.1038/ni.2490
10.1038/nri3328
10.1038/nri3369
10.3389/fimmu.2018.00384
10.1080/2162402X.2021.2009666
10.3389/fimmu.2014.00543
10.1146/annurev.immunol.25.022106.141711
10.1007/s00262-013-1509-4
10.1073/pnas.1323405111
10.3389/fimmu.2023.1176724
10.1016/j.trsl.2017.06.003
10.1126/science.278.5343.1626
10.1038/nature05907
10.1038/ni1002
10.1007/s12016-020-08784-8
10.4049/jimmunol.171.4.1637
10.1038/nm851
10.3389/fimmu.2024.1364774
10.1038/ni.3203
10.1016/j.jaci.2019.02.024
10.1371/journal.pone.0119901
10.1084/jem.189.3.553
10.3389/fchem.2019.00811
10.3389/fimmu.2018.01942
10.1084/jem.20031389
10.1038/s41598-020-76659-1
10.1172/jci.insight.164157
10.1038/s41598-017-16832-1
10.1126/science.280.5367.1265
10.3389/fimmu.2018.01942
10.1016/j.coi.2010.10.008
10.1038/s41577-018-0034-2
10.4049/jimmunol.0804213
10.1084/jem.20080698
10.1002/ehf2.14111
10.1038/ni.3244
10.1016/j.immuni.2015.01.016
10.1016/j.mam.2021.100995
10.1038/nature07548
10.3389/fimmu.2018.01027
10.1186/s12967-022-03337-3
10.1038/ni.2541
10.1038/ni1360
10.1038/ni805
10.1126/scisignal.aam8858
10.1038/ncomms3675
10.1172/JCI44845
10.1152/ajplung.00114.2011
10.1073/pnas.1220601110
10.3389/fimmu.2018.00548
10.1016/j.xphs.2021.02.006
10.1016/j.coi.2016.01.007
10.1016/j.it.2013.07.005
10.3390/cancers14092266
10.3389/fimmu.2018.00367
10.1016/S1470-2045(02)00850-1
10.1038/s41591-020-1074-2
10.3389/fimmu.2017.01178
10.3389/fimmu.2017.01124
10.4168/aair.2018.10.5.448
10.3389/fimmu.2018.01766
10.3389/fimmu.2017.01125
10.1038/s41421-022-00433-y
10.32481/djph.2023.11.004
10.3389/fimmu.2022.983852
10.1016/j.amjmed.2023.05.001
10.1016/S2213-2600(16)30031-5
10.1016/S2213-2600(15)00042-9
10.1177/0897190019840597
10.1016/S0140-6736(16)31324-1
10.1056/NEJMoa1703501
10.2147/DDDT.S250825
10.1038/s41577-022-00735-y
10.1056/NEJMoa2034975
10.1016/j.cell.2021.02.016
10.1056/NEJMra2032506
10.4049/jimmunol.206.Supp.66.07
10.1186/s12935-022-02778-6
10.1016/j.it.2011.06.010
10.1002/eji.202048798
10.1073/pnas.1203494109
10.1111/ajt.14185
10.1007/s00005-010-0074-1
10.1158/2159-8290.CD-12-0548
10.3390/vaccines8040753
10.1111/ejh.13170
10.1002/cti2.1049
10.1158/1078-0432.CCR-19-3417
10.3390/cancers14020299
10.3390/biom12091303
10.1016/j.ymthe.2021.04.038
10.3390/biom10020263
10.3389/fimmu.2019.02711
10.1038/ni.1848
10.1182/blood-2021-149712
10.1038/s41571-021-00530-z
10.4110/in.2011.11.6.406
10.1002/eji.200737389
10.21769/BioProtoc.2277
10.1016/j.humimm.2013.12.004
10.1016/j.stem.2023.02.009
10.1089/hum.2017.236
10.4049/jimmunol.1800429
10.1186/s13045-023-01492-8
10.1016/j.ymthe.2024.04.005
10.1038/s41409-020-0926-1
10.1177/09636897221094244
10.1097/HS9.0000000000000220
10.1007/s12015-021-10246-3
10.1016/S0065-230X(08)00408-9
10.1007/s12094-020-02490-9
10.1038/s41467-020-14332-x
10.1016/j.leukres.2004.06.005
10.3390/ijms19082365
10.1016/j.intimp.2023.110921
10.4049/jimmunol.0902301
10.3390/nu13010177
10.4049/jimmunol.1001348
10.3390/ijms241512469
10.1038/s41581-023-00694-0
10.1038/sj.onc.1207523
10.1038/nri911
10.1038/nri3839
10.1183/16000617.0036-2023
10.1165/rcmb.2002-0074OC
10.1038/377446a0
10.1164/ajrccm.161.1.9902104
10.2147/JAA.S403645
10.1165/rcmb.2010-0027TR
10.1007/s00011-018-1191-2
10.1111/all.15473
10.1016/j.immuni.2009.08.007
10.3389/fimmu.2021.763243
10.1136/jim-2021-002098
10.3389/fphar.2019.01387
10.3389/fimmu.2022.746360
10.1165/rcmb.2002-0249OC
10.1172/JCI142116
10.1016/j.omtm.2022.10.010
10.1002/acg2.84
10.1038/s41591-022-01726-1
10.1038/s41598-020-60229-6
10.3390/ijms222111898
10.1016/j.coi.2014.12.009
10.1164/ajrccm.161.supplement_2.a1q4-6
10.1183/13993003.00634-2017
10.1016/j.jaci.2019.05.002
10.1186/s12967-023-04418-7
10.3390/ijms23095066
10.1172/JCI85664
10.1016/S2213-2600(20)30414-8
10.1056/NEJMoa0805435
10.1016/j.chest.2017.01.021
10.1172/JCI84144
10.1016/S0140-6736(12)60988-X
10.1164/rccm.201103-0396OC
10.3389/fimmu.2020.593748
10.1038/s41467-017-02023-z
10.3390/cells12212556
10.1084/jem.20191520
10.1146/annurev.iy.08.040190.003203
10.1111/all.14908
10.1111/all.15843
10.1186/s13223-021-00534-5
10.1074/jbc.RA119.010572
10.1146/annurev-immunol-061020-053712
10.1053/j.gastro.2005.06.014
10.1016/1074-7613(95)90164-7
10.1371/journal.pone.0019098
10.3389/falgy.2023.1117611
10.1038/35018500
10.1084/jem.20050811
10.1111/j.1365-2249.2010.04210.x
10.1038/s41598-020-61455-8
10.1016/j.tips.2023.06.001
10.1016/S0002-9440(10)63255-5
10.1164/rccm.200608-1243OC
10.1002/clt2.12222
10.1016/j.cellimm.2021.104287
10.1016/j.aller.2018.07.003
10.1146/annurev-immunol-030409-101243
10.1016/j.apsb.2019.08.010
10.1126/sciadv.aaz3223
10.3389/fimmu.2018.02231
10.1016/j.biopha.2019.109685
10.1002/ijc.34281
10.18240/ijo.2021.07.01
10.1038/s41467-022-32195-2
10.1016/j.cyto.2019.154934
10.3389/fimmu.2022.1031268
10.1038/ni.2256
10.1038/nri3632
10.1038/mt.2009.83
10.1038/nm1385
10.3389/fimmu.2022.796682
10.1111/all.14896
10.1080/2162402X.2021.2002068
10.1186/s13045-019-0746-1
10.1038/emm.2017.107
10.3389/fimmu.2023.1070779
10.1128/CVI.00434-10
10.1002/adma.202108525
10.1038/s41467-020-18570-x
10.1038/ni1443
10.1056/NEJMra1514296
10.1007/s00262-022-03337-8
10.5604/01.3001.0016.2204
10.3389/fimmu.2022.973673
10.1016/B978-0-323-37579-5.00008-8
10.5772/intechopen.102631
10.1038/s41467-020-17813-1
10.1111/j.1398-9995.2010.02458.x
10.1038/mi.2012.111
10.1016/j.biopha.2023.115569
10.1038/mi.2009.112
10.1371/journal.pbio.3001272
10.3389/fimmu.2023.1163633
10.3389/fimmu.2016.00382
10.1038/s41418-023-01229-7
10.1186/s12935-023-02996-6
10.2147/JIR.S417801
10.1111/j.1398-9995.2011.02763.x
10.1038/s41392-019-0079-0
10.3389/fphar.2021.805391
10.1016/j.immuni.2006.08.016
10.3390/cancers14174318
10.3390/ijms242015134
10.1021/acsnano.2c04420
10.1371/journal.pone.0249605
10.1084/jem.20062093
10.1084/jem.20100687
10.1038/emm.2004.37
10.3389/fimmu.2020.00537
10.1038/mi.2014.9
10.1016/j.rmed.2020.106235
10.3389/fmed.2018.00212
10.1165/rcmb.2013-0490OC
10.1007/s10495-022-01774-5
10.1038/s41467-021-24767-5
10.1002/JLB.2MR1119-224R
10.1080/2162402X.2015.1113367
10.1084/jem.20132687
10.3389/fimmu.2022.896744
10.1111/j.1365-2249.2012.04572.x
10.1172/JCI23792
10.1136/esmoopen-2020-000733
10.3390/ijms23137363
10.1038/16717
10.1038/35051100
10.1016/S1074-7613(00)00011-X
10.1016/j.intimp.2021.108394
10.3389/fimmu.2020.02104
10.1038/45582
10.1038/nri727
10.1146/annurev.immunol.23.021704.115611
10.1093/intimm/dxq476
10.1038/ni947
10.1084/jem.20190490
10.1016/j.immuni.2015.02.007
10.1371/journal.pone.0162393
10.4049/jimmunol.1103581
10.1111/all.13139
10.4049/jimmunol.180.8.5448
10.1016/j.jcyt.2021.02.117
10.3389/fonc.2023.1200914
10.3390/jof9010085
10.1038/nm.3360
10.1183/09031936.00139513
10.3390/biomedicines10061452
10.1038/nri1745
10.1126/scitranslmed.abh1209
10.1126/science.1221789
10.1111/pim.12960
10.3390/jof9030381
10.3390/pharmaceutics14030641
10.1073/pnas.1312789111
10.1186/s12935-023-02923-9
10.1016/j.lfs.2021.119503
10.1007/s12015-019-09901-7
10.1371/journal.pcbi.1009883
10.1038/s41591-021-01614-0
10.2147/JAA.S285742
10.1016/j.xcrm.2022.100857
10.1186/s12890-023-02570-w
10.1183/13993003.00521-2020
10.1007/s12325-023-02743-3
10.4168/aair.2024.16.2.130
10.1183/13993003.02135-2016
10.3390/ijms21082856
10.1016/j.jbi.2023.104367
10.1016/j.bios.2021.113088
10.3389/fimmu.2023.1273507
10.1002/ctm2.1274
10.1038/s41571-023-00729-2
10.1126/science.abq0225
10.1002/1878-0261.13420
10.3389/fimmu.2023.1285406
10.1016/j.compbiomed.2022.106084
10.3389/fmed.2022.913287
10.1126/science.abl5311
10.1111/imr.13236
10.1186/s12967-023-04292-3
10.1200/CCI.21.00023
10.2147/DDDT.S424991
10.1016/j.ejphar.2016.11.047
10.1172/JCI83476
10.1158/1078-0432.CCR-19-0421
10.3390/ijms22031096
10.1371/journal.pone.0161820
10.3389/fimmu.2023.1118681
10.1182/bloodadvances.2023010032
10.1016/j.isci.2023.108597
10.1136/jitc-2023-007829
10.1016/j.phrs.2023.106942 | [
"Taheri",
"Javan",
"Poudineh",
"Athari"
] | [
"Student Research Committee, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.",
"Student Research Committee, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.",
"Student Research Committee, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.",
"Cancer Gene therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. [email protected].\nDepartment of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. [email protected]."
] | [
"38995478",
"22561835",
"33860870",
"34777398",
"35125181",
"24337046",
"30645143",
"9802359",
"28078100",
"38117887",
"28955341",
"25810311",
"23202270",
"23154222",
"23334244",
"29559971",
"36524208",
"25389427",
"17150027",
"24384834",
"25143585",
"37153585",
"28651074",
"9374463",
"17581592",
"14578883",
"32246390",
"12902459",
"12669034",
"38629075",
"26075912",
"30851295",
"25830340",
"9927517",
"31850305",
"15051763",
"33173202",
"36477357",
"29192280",
"9596580",
"30210497",
"21115332",
"29967365",
"19342692",
"19015310",
"35975554",
"34920650",
"26322482",
"25692703",
"19060881",
"29867994",
"35296330",
"23435120",
"16785889",
"12055625",
"29535264",
"24157859",
"21157038",
"21856813",
"23307809",
"29599785",
"33577827",
"26845614",
"24055329",
"35565395",
"29535734",
"12217795",
"33046868",
"29018445",
"28955340",
"30088365",
"30105031",
"35973984",
"38173965",
"36561741",
"37210021",
"27177493",
"25736990",
"31046541",
"28530840",
"33536746",
"35650271",
"33979488",
"33711259",
"35020986",
"36419058",
"21798806",
"32712954",
"23027937",
"28027623",
"23550147",
"33322408",
"30187578",
"32273277",
"35053463",
"36139142",
"33940156",
"32050611",
"31824500",
"20190758",
"34230645",
"22346782",
"18493987",
"34541057",
"24373798",
"36948187",
"29320890",
"30111631",
"37596653",
"38584391",
"32390002",
"35506155",
"35309781",
"34472037",
"19055947",
"32997278",
"31974378",
"15607362",
"30103488",
"37725846",
"20525882",
"33435598",
"21131420",
"37569846",
"36959481",
"9721089",
"12360212",
"25998963",
"37437915",
"12600835",
"7566124",
"10619818",
"37038432",
"20525803",
"30306206",
"35950646",
"19766086",
"35069535",
"35168999",
"31866859",
"35774789",
"14722222",
"36381305",
"35314843",
"32127556",
"34769327",
"25597442",
"28461308",
"31082458",
"37587450",
"35563461",
"27548519",
"33357499",
"19264687",
"28130045",
"27367183",
"21852542",
"33488590",
"29196657",
"37947634",
"2140512",
"33999439",
"37555488",
"31488546",
"36737596",
"16143132",
"7621072",
"21544204",
"37056355",
"10917520",
"16172256",
"20831712",
"32170187",
"37391294",
"15579447",
"17446336",
"36825516",
"33494007",
"32140389",
"32637585",
"30364107",
"31862474",
"36082452",
"24617045",
"34282378",
"35922425",
"31783259",
"36685514",
"22366892",
"24625841",
"19384291",
"16604087",
"35250975",
"33969495",
"34777920",
"28775364",
"36865540",
"21346053",
"32973173",
"17304234",
"27806234",
"36436018",
"36479132",
"32778730",
"20722638",
"23149662",
"37769390",
"19741598",
"34010274",
"37261359",
"27729910",
"37838774",
"37543612",
"37415620",
"22175699",
"31637021",
"35046828",
"17027299",
"36077853",
"37894816",
"35939651",
"33822811",
"33639624",
"17517968",
"20937702",
"15272240",
"32300343",
"24569802",
"33249302",
"24484417",
"36207556",
"34290245",
"32052477",
"27141396",
"24958847",
"35911679",
"22519594",
"16528411",
"35806368",
"9930702",
"11343121",
"10933398",
"34922247",
"32983168",
"10617205",
"11910893",
"15771580",
"21402623",
"12833154",
"31201208",
"25769613",
"27617447",
"22815292",
"28160290",
"18390727",
"33863641",
"37719008",
"24100979",
"24311776",
"35740474",
"16341139",
"36170447",
"22674328",
"36403106",
"35336015",
"25002471",
"37158883",
"33865882",
"31161552",
"35303007",
"35058619",
"35791395",
"36543110",
"37507662",
"32381498",
"38110652",
"38528381",
"28179442",
"32325898",
"37105509",
"33647790",
"37854590",
"37228183",
"36721024",
"36480602",
"37002698",
"38090582",
"36155267",
"35587980",
"37415280",
"37420216",
"34110929",
"37701048",
"27894811",
"27183388",
"31484667",
"33499253",
"27598655",
"36936927",
"37399471",
"38179061",
"37775021"
] | [] | 11.447012 | 5.614297 |
38994929 | 735 | Evaluation of the Immunomodulatory Effects of Radiation for Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme. | Standard-of-care treatment for Glioblastoma Multiforme (GBM) is comprised of surgery and adjuvant chemoradiation. Chimeric Antigen Receptor (CAR) T cell therapy has demonstrated disease-modifying activity in GBM and holds great promise. Radiation, a standard-of-care treatment for GBM, has well-known immunomodulatory properties and may overcome the immunosuppressive tumor microenvironment (TME); however, radiation dose optimization and integration with CAR T cell therapy is not well defined. Murine immunocompetent models of GBM were treated with titrated doses of stereotactic radiosurgery (SRS) of 5, 10, and 20 Gray (Gy), and the TME was analyzed using Nanostring. A conditioning dose of 10 Gy was determined based on tumor growth kinetics and gene expression changes in the TME. We demonstrate that a conditioning dose of 10 Gy activates innate and adaptive immune cells in the TME. Mice treated with 10 Gy in combination with mCAR T cells demonstrated enhanced antitumor activity and superior memory responses to rechallenge with IL13Rα2-positive tumors. Furthermore, 10 Gy plus mCAR T cells also protected against IL13Rα2-negative tumors through a mechanism that was, in part, c-GAS-STING pathway-dependent. Together, these findings support combination conditioning with low-dose 10 Gy radiation in combination with mCAR T cells as a therapeutic strategy for GBM. | [
0.03064398281276226,
0.05300973355770111,
0.03909165412187576,
0.04618382081389427,
-0.046909984201192856,
-0.021627487614750862,
0.010226763784885406,
0.030619777739048004,
-0.011775906197726727,
-0.01131600420922041,
0.0009999838657677174,
0.005682207643985748,
-0.021530665457248688,
-0.00755207147449255,
0.02899801917374134,
-0.03981781378388405,
0.01949741505086422,
-0.0470794215798378,
0.0054946159943938255,
0.02691635675728321,
-0.00325562059879303,
0.0423593744635582,
-0.008659467101097107,
-0.010541433468461037,
-0.028731759637594223,
0.003052900778129697,
0.01145518571138382,
0.01934008114039898,
0.008229821920394897,
-0.012030062265694141,
-0.015781892463564873,
-0.003782087005674839,
-0.04173003509640694,
-0.049572572112083435,
-0.02208738960325718,
0.0038062925450503826,
0.02035670541226864,
0.009228292852640152,
0.008865212090313435,
-0.007473404053598642,
0.005043791141360998,
-0.019364286214113235,
-0.003585418686270714,
0.08011973649263382,
-0.011812214739620686,
-0.011019488796591759,
-0.0017488370649516582,
-0.06230458989739418,
0.0207924023270607,
-0.00786674115806818,
-0.016895338892936707,
0.030280902981758118,
-0.009131470695137978,
0.059738822281360626,
-0.008556594140827656,
0.03170901909470558,
-0.007170837372541428,
-0.002158815274015069,
0.006214725319296122,
0.012108730152249336,
-0.006012005731463432,
-0.021796924993395805,
0.03822026029229164,
-0.042044706642627716,
-0.06496717780828476,
-0.039648376405239105,
-0.014728959649801254,
-0.02322504110634327,
0.011999806389212608,
-0.014559522271156311,
0.0010491509456187487,
-0.049959857016801834,
0.022075286135077477,
-0.02926427684724331,
0.06046498194336891,
0.014014901593327522,
0.004532453138381243,
-0.011055797338485718,
0.035993367433547974,
-0.03379067778587341,
-0.004822917282581329,
-0.043569643050432205,
0.023176629096269608,
-0.050831250846385956,
-0.03792979568243027,
0.011890881694853306,
0.01257468294352293,
-0.026504866778850555,
-0.08011973649263382,
0.0036640861071646214,
-0.0036489577032625675,
0.0018547355430200696,
-0.023321861401200294,
0.0423835813999176,
-0.03405693918466568,
-0.039261091500520706,
0.06419260799884796,
-0.019327977672219276,
0.039140064269304276,
0.044320009648799896,
0.028586527332663536,
-0.013724437914788723,
-0.008405310101807117,
-0.029845206066966057,
0.08607424795627594,
0.0024417154490947723,
-0.06085227057337761,
-0.009936299175024033,
0.03437160700559616,
-0.0008282770868390799,
0.1126033216714859,
0.018492892384529114,
0.02071978524327278,
0.03749409690499306,
-0.03938211500644684,
-0.0205987598747015,
-0.03107967972755432,
-0.01592712476849556,
-0.030886035412549973,
0.012344731949269772,
-0.02800559811294079,
0.012175294570624828,
0.003600546857342124,
-0.0564953051507473,
0.026504866778850555,
-0.05402635782957077,
0.0776991993188858,
-0.055333446711301804,
-0.016338616609573364,
-0.0266743041574955,
0.03584813326597214,
-0.006163289304822683,
0.027908777818083763,
-0.04887061566114426,
-0.06782341003417969,
-0.00849608052521944,
-0.04044715315103531,
0.0016974007012322545,
-0.061965715140104294,
0.026577481999993324,
0.009742656722664833,
-0.011430979706346989,
-0.006117904093116522,
0.000996201764792204,
-0.04722465202212334,
-0.039963044226169586,
-0.059738822281360626,
0.04657110944390297,
0.016181280836462975,
0.017403652891516685,
-0.052283573895692825,
0.01911013014614582,
0.013954388909041882,
0.0020771222189068794,
0.009427987039089203,
-0.04606279358267784,
-0.012707812711596489,
0.07445567846298218,
-0.02628701739013195,
-0.06782341003417969,
0.020707683637738228,
0.04076182097196579,
0.003906139638274908,
-0.011031591333448887,
0.04163321480154991,
0.02754569612443447,
-0.029942026361823082,
0.03773615136742592,
-0.0568825900554657,
-0.0014288724632933736,
0.005960569251328707,
-0.00017756898887455463,
-0.06477353721857071,
-0.0337422676384449,
-0.05983564257621765,
0.02295878157019615,
-0.016665387898683548,
0.0018517097923904657,
-0.019557928666472435,
-0.014099620282649994,
0.000984099111519754,
0.0031345938332378864,
0.02597234770655632,
0.047103624790906906,
-0.01969105750322342,
0.03785717859864235,
-0.004477991256862879,
0.016253897920250893,
-0.04340020567178726,
-0.03829287737607956,
0.02067137509584427,
-0.04330338537693024,
0.04841071367263794,
0.026964768767356873,
-0.036090187728405,
-0.03166060894727707,
0.04962098225951195,
0.00281084724701941,
-0.03582393005490303,
0.02460474520921707,
0.0329434908926487,
-0.04436841979622841,
-0.02848970517516136,
-0.025827117264270782,
-0.03422637656331062,
-0.04173003509640694,
0.006251033395528793,
0.04064079374074936,
-0.021337023004889488,
0.019606338813900948,
0.037881385535001755,
-0.02357601746916771,
-0.004756352864205837,
-0.004208706319332123,
-0.02401171438395977,
-0.030159875750541687,
-0.03267723321914673,
0.0022087388206273317,
0.03347600996494293,
0.03032931312918663,
0.02012675441801548,
0.000023366206733044237,
0.010958975180983543,
0.01930377259850502,
-0.021082866936922073,
0.013070893473923206,
0.01102554053068161,
0.006686729844659567,
0.008895468898117542,
-0.023079808801412582,
-0.013252433389425278,
-0.01406331267207861,
0.021203892305493355,
-0.046861570328474045,
-0.05300973355770111,
-0.011509647592902184,
0.05150900036096573,
-0.012024011462926865,
0.06453148275613785,
-0.02385438047349453,
0.025488240644335747,
0.04340020567178726,
0.029603151604533195,
-0.052670858800411224,
-0.02565767802298069,
0.004214758053421974,
-0.00504076573997736,
-0.07145421206951141,
-0.0024386898148804903,
-0.008483977988362312,
-0.06017451733350754,
-0.020102549344301224,
-0.017790937796235085,
-0.032628823071718216,
0.004502196330577135,
0.01750047318637371,
0.022583598271012306,
-0.007806228008121252,
-0.002134609967470169,
-0.03345180302858353,
-0.00911936815828085,
-0.016387026757001877,
-0.006432573776692152,
-0.047418296337127686,
-0.03008725866675377,
0.04766034707427025,
-0.038776982575654984,
-0.016072357073426247,
0.02044142410159111,
0.025197777897119522,
-0.003382698632776737,
-0.008217718452215195,
0.06811387836933136,
-0.015709277242422104,
-0.03959996625781059,
-0.005930312443524599,
0.011473339051008224,
0.05194469541311264,
-0.0041784499771893024,
-0.0035097768995910883,
-0.006329700816422701,
0.01183036807924509,
0.017355240881443024,
-0.01573348231613636,
-0.0024296126794070005,
-0.0066564735025167465,
-0.0017609397182241082,
0.031442757695913315,
-0.025923937559127808,
-0.055962786078453064,
0.02205108106136322,
0.022825652733445168,
0.01298617385327816,
-0.01153385266661644,
-0.005966620519757271,
0.007685200776904821,
0.021010249853134155,
-0.0040604486130177975,
-0.01886807568371296,
0.04424739256501198,
-0.005491590593010187,
0.040035661309957504,
-0.005521847400814295,
-0.025439830496907234,
0.0022389956284314394,
0.033016107976436615,
0.004798712208867073,
0.01898910291492939,
0.009052803739905357,
0.04291610047221184,
0.03243517875671387,
-0.005591437686234713,
0.01851709932088852,
0.0329434908926487,
0.007509712129831314,
0.04284348338842392,
0.021131277084350586,
-0.043376002460718155,
-0.02691635675728321,
-0.03972099348902702,
0.004656505770981312,
0.01238104049116373,
-0.02346709370613098,
0.00006779390969313681,
0.00034076604060828686,
-0.010323585011065006,
-0.013712335377931595,
-0.010238866321742535,
0.019521620124578476,
-0.05775398388504982,
0.02507675066590309,
0.00882890447974205,
0.05213833972811699,
0.01478947326540947,
0.022765139117836952,
-0.00994840171188116,
-0.0317816361784935,
-0.023212937638163567,
0.017125289887189865,
-0.024592643603682518,
-0.004202655050903559,
0.009930248372256756,
-0.0051375869661569595,
0.023128218948841095,
-0.0031134141609072685,
0.011570161208510399,
-0.0012798582902178168,
0.030982857570052147,
0.040156688541173935,
0.0093190623447299,
0.03696158155798912,
0.021554870530962944,
-0.008520285598933697,
0.01926746405661106,
0.020417219027876854,
0.009379575960338116,
-0.005633797030895948,
-0.005210203118622303,
0.0015430914936587214,
0.003887985600158572,
-0.013034584932029247,
0.01351869199424982,
-0.003591469954699278,
0.030886035412549973,
0.0329434908926487,
0.06956619769334793,
-0.02844129502773285,
0.04417477920651436,
-0.036695320159196854,
-0.02130071446299553,
-0.028392884880304337,
0.01145518571138382,
0.013458178378641605,
0.01592712476849556,
-0.03904324024915695,
0.012211603112518787,
-0.0021119173616170883,
0.014148031361401081,
0.024907313287258148,
0.01134021021425724,
0.06767817586660385,
0.0022147903218865395,
-0.003379672998562455,
-0.01134021021425724,
-0.027690928429365158,
-0.002824462717399001,
0.045094579458236694,
0.016883237287402153,
-0.06738771498203278,
-0.02268042042851448,
-0.00750366086140275,
-0.01029937993735075,
0.02749728597700596,
-0.008786545135080814,
-0.0372762493789196,
0.0768762156367302,
0.003887985600158572,
0.0466921329498291,
0.02938530407845974,
0.01993311196565628,
-0.010650357231497765,
-0.045142993330955505,
-0.02773934043943882,
-0.05087966099381447,
0.03429898992180824,
-0.011860624887049198,
0.02977258898317814,
0.004405375104397535,
-0.011430979706346989,
-0.018565509468317032,
0.0042389631271362305,
0.008266129530966282,
0.023019295185804367,
0.005340307019650936,
-0.004853174090385437,
-0.017439959570765495,
-0.019243258982896805,
0.03575131297111511,
-0.009567167609930038,
0.03468627855181694,
0.025923937559127808,
-0.008913623169064522,
0.04107649251818657,
-0.023709148168563843,
-0.010166250169277191,
-0.004910661838948727,
0.013155612163245678,
-0.008786545135080814,
0.010886359959840775,
-0.03659849986433983,
-0.018117710947990417,
0.059738822281360626,
-0.017996683716773987,
-0.017706219106912613,
0.00933721661567688,
0.06409578770399094,
-0.04320656135678291,
-0.014801575802266598,
-0.06961461156606674,
0.02812662534415722,
-0.014825781807303429,
-0.02051404118537903,
0.003945473115891218,
-0.05359066277742386,
0.028538117185235023,
0.004626248963177204,
-0.00233430415391922,
0.06743612885475159,
-0.029215866699814796,
-0.03899483010172844,
-0.006626216694712639,
-0.019436901435256004,
0.0017110161716118455,
0.0020377885084599257,
-0.024665258824825287,
-0.008417412638664246,
0.0761016458272934,
-0.05567232146859169,
0.011164721101522446,
-0.02749728597700596,
0.0368889644742012,
-0.04782978817820549,
0.007328172214329243,
-0.05543026700615883,
-0.01835976354777813,
0.034662071615457535,
0.029990438371896744,
-0.0010332661913707852,
0.007164785638451576,
0.02887699194252491,
0.01648384891450405,
0.026867946609854698,
-0.05150900036096573,
0.01812981255352497,
0.016023946925997734,
0.010874256491661072,
-0.03379067778587341,
-0.019763674587011337,
0.06830751895904541,
0.006765397265553474,
0.007969614118337631,
0.020550347864627838,
-0.005721541587263346,
-0.012235808186233044,
0.019594237208366394,
0.023212937638163567,
-0.004459836985915899,
-0.02718261629343033,
0.028513910248875618,
0.006952988915145397,
-0.04913687705993652,
-0.019122231751680374,
0.003966652788221836,
-0.011757752858102322,
-0.004384195432066917,
-0.0005230626557022333,
-0.03071659803390503,
-0.020296191796660423,
-0.02597234770655632,
0.02773934043943882,
-0.029215866699814796,
0.040979668498039246,
0.00021709180145990103,
-0.026650099083781242,
-0.019037513062357903,
0.013542897067964077,
-0.04417477920651436,
0.0486527681350708,
-0.007291864138096571,
-0.01683482527732849,
-0.012635196559131145,
-0.009512705728411674,
0.014680549502372742,
0.007679149508476257,
-0.02514936588704586,
-0.01585450954735279,
-0.025415625423192978,
0.013591308146715164,
-0.0013297818368300796,
0.005546052474528551,
-0.03260461613535881,
-0.013772848062217236,
-0.015249375253915787,
0.017548883333802223,
0.012877250090241432,
-0.005219280254095793,
-0.03192686662077904,
-0.02931268885731697,
-0.03202368691563606,
-0.07126057147979736,
-0.0038698315620422363,
-0.02950633130967617,
-0.007334223482757807,
-0.003394801402464509,
-0.03751830384135246,
-0.025197777897119522,
-0.029554741457104683,
0.019824188202619553,
-0.033258162438869476,
-0.02408433146774769,
-0.013119303621351719,
-0.00004004284710390493,
0.009754759259521961,
0.007812279276549816,
0.011188926175236702,
0.024217460304498672,
0.009476397186517715,
-0.030474545434117317,
0.025367215275764465,
-0.010172301903367043,
0.04151218757033348,
-0.021276509389281273,
0.028731759637594223,
0.009627681225538254,
0.011594366282224655,
-0.0037851128727197647,
-0.008157205767929554,
-0.018178222700953484,
-0.01437798235565424,
-0.01797247864305973,
-0.0029833102598786354,
-0.015430915169417858,
0.002379689132794738,
-0.04156059771776199,
-0.02009044587612152,
0.012126884423196316,
0.008151154033839703,
-0.0045748124830424786,
-0.04189947247505188,
0.008665517903864384,
-0.032822463661432266,
0.02401171438395977,
0.009167779237031937,
-0.023636531084775925,
0.021010249853134155,
-0.019327977672219276,
-0.012102678418159485,
0.01100133452564478,
-0.01937638781964779,
-0.0022163030225783587,
-0.021954258903861046,
-0.021276509389281273,
-0.012635196559131145,
0.03875277563929558,
-0.019485313445329666,
0.027981393039226532,
-0.03763933107256889,
0.006372060161083937,
0.004838045686483383,
0.012780428864061832,
-0.0007288081687875092,
-0.008822852745652199,
0.05998087674379349,
-0.019921008497476578,
-0.02122809924185276,
0.0063539063557982445,
-0.008568696677684784,
-0.010117839090526104,
-0.02761831320822239,
0.027957187965512276,
0.00849608052521944,
-0.01629020646214485,
0.006420471239835024,
-0.004048346076160669,
-0.0017715295543894172,
0.019194848835468292,
-0.010486971586942673,
-0.030038848519325256,
0.003065003314986825,
0.0005574796232394874,
0.04182685911655426,
0.02616599202156067,
-0.051218535751104355,
-0.028852786868810654,
-0.00011270619870629162,
0.01624179445207119,
-0.0034825457260012627,
-0.009676091372966766,
0.03853492811322212,
0.008659467101097107,
-0.02264411188662052,
0.01883176900446415,
-0.007691252510994673,
0.005748772528022528,
-0.0027246156241744757,
-0.03345180302858353,
-0.032822463661432266,
-0.004372092895209789,
0.03362124040722847,
0.004393272567540407,
-0.020501937717199326,
-0.04359384998679161,
0.0005079343100078404,
0.04763614386320114,
-0.004956047050654888,
-0.016193384304642677,
0.0325562059879303,
-0.007158734370023012,
0.01194534357637167,
-0.013918080367147923,
0.00015790213365107775,
-0.014716857112944126,
-0.00816325657069683,
-0.051654234528541565,
0.020901326090097427,
-0.0016883236821740866,
-0.0463048480451107,
-0.016774313524365425,
-0.0019091975409537554,
-0.006293392740190029,
-0.02255939319729805,
-0.04477991163730621,
-0.010880308225750923,
0.019352182745933533,
-0.0015899894060567021,
-0.004553632810711861,
-0.0007446929230354726,
0.001228421926498413,
0.016072357073426247,
0.04649849236011505,
-0.03746989369392395,
-0.0018774280324578285,
-0.027763545513153076,
-0.015830304473638535,
0.009621629491448402,
0.03425057977437973,
-0.009373524226248264,
-0.022777240723371506,
0.00023827148834243417,
-0.014753165654838085,
0.07997450232505798,
-0.0019394542323425412,
0.04323076829314232,
-0.031055472791194916,
0.03771194815635681,
0.007322120480239391,
-0.012193448841571808,
-0.02781195566058159,
-0.012108730152249336,
-0.027690928429365158,
0.01741575449705124,
-0.013070893473923206,
-0.028199240565299988,
-0.037566713988780975,
0.02247467450797558,
0.0004799468442797661,
0.01820242963731289,
-0.020489834249019623,
0.01585450954735279,
-0.01808140240609646,
0.007025605067610741,
-0.03652588278055191,
-0.020465629175305367,
-0.011328107677400112,
-0.019509518519043922,
0.007667046971619129,
0.008792595937848091,
0.008695774711668491,
-0.023176629096269608,
-0.03773615136742592,
0.0478539913892746,
0.021627487614750862,
0.01797247864305973,
-0.013833361677825451,
0.029917821288108826,
-0.033209752291440964,
-0.013482384383678436,
-0.007533917669206858,
0.03906744718551636,
-0.011309953406453133,
0.0013017944293096662,
0.0010438560275360942,
-0.021349124610424042,
-0.0149105004966259,
0.030063053593039513,
0.002547613810747862,
0.003400852670893073,
0.027376258745789528,
-0.020780298858880997,
0.029675768688321114,
-0.026190197095274925,
-0.011297850869596004,
-0.03720363602042198,
-0.0018849922344088554,
0.02679533138871193,
0.024858901277184486,
-0.043835900723934174,
0.034976743161678314,
-0.04908846318721771,
-0.010371996089816093,
0.0237333532422781,
-0.010462765581905842,
-0.009064906276762486,
0.017246317118406296,
-0.04272245615720749,
0.0564953051507473,
-0.015818201005458832,
-0.04807183891534805,
0.005019586067646742,
-0.014051210135221481,
0.03166060894727707,
-0.013143508695065975,
-0.05915789306163788,
-0.006251033395528793,
0.010656408965587616,
0.022063182666897774,
0.007394736632704735,
-0.03241097554564476,
-0.0038183950819075108,
-0.015249375253915787,
0.00819956511259079,
0.009010444395244122,
-0.028199240565299988,
-0.007297915406525135,
0.004738198593258858,
-0.03347600996494293,
-0.004438657313585281,
0.00467768544331193,
-0.03715522214770317,
0.0010491509456187487,
-0.0639505535364151,
0.005222305655479431,
-0.009095163084566593,
-0.025318803265690804,
-0.011225234717130661,
-0.000027254665837972425,
0.01702846959233284,
0.0059968773275613785,
-0.0024250743445008993,
0.01016019843518734,
-0.006886424031108618,
-0.028296062722802162,
0.021361228078603745,
-0.020973943173885345,
-0.005887953098863363,
0.021917950361967087,
-0.02114338055253029,
0.016895338892936707,
-0.012598888948559761,
-0.003776035737246275,
0.0015264503890648484,
-0.010269123129546642,
-0.00837505329400301,
0.015612456016242504,
-0.03013567067682743,
0.015261477790772915,
0.012768326327204704,
0.04257722198963165,
-0.01867443323135376,
0.00839925929903984,
-0.02385438047349453,
0.008895468898117542,
-0.020066240802407265,
0.02628701739013195,
-0.01153385266661644,
0.03928529471158981,
0.040471356362104416,
-0.08941458910703659,
0.005446205381304026,
-0.0036610602401196957,
-0.006886424031108618,
-0.03538823127746582,
0.03095865249633789,
-0.02180902659893036,
-0.005340307019650936,
0.0368889644742012,
-0.0009636757895350456,
-0.023721249774098396,
-0.03369385749101639,
-0.015370401553809643,
0.001180767547339201,
0.026940563693642616,
-0.03265302628278732,
-0.012526272796094418,
-0.055962786078453064,
0.009343268349766731,
0.01981208473443985,
0.020659273490309715,
0.007376582827419043,
-0.018117710947990417,
0.028465500101447105,
-0.002813872881233692,
0.011697239242494106,
0.011424928903579712,
0.009561115875840187,
-0.012780428864061832,
-0.024072227999567986,
-0.01965475082397461,
0.020973943173885345,
0.00472609605640173,
0.04076182097196579,
-0.04836230352520943,
-0.03981781378388405,
0.01564876362681389,
-0.000721622200217098,
0.017633602023124695,
0.020925531163811684,
0.020501937717199326,
-0.005839542485773563,
0.014390084892511368,
0.012193448841571808,
-0.03228994831442833,
-0.007927254773676395,
-0.010123890824615955,
-0.001594527973793447,
0.014123826287686825,
-0.02950633130967617,
-0.008145103231072426,
-0.027134206146001816,
-0.04233517125248909,
0.011479390785098076,
0.01163067389279604,
-0.05388112738728523,
0.025681884959340096,
0.016895338892936707,
0.021409638226032257,
0.003243517829105258,
-0.008381105028092861,
0.028150830417871475,
0.006456779316067696,
-0.021942157298326492,
-0.023684943094849586,
-0.02502834051847458,
-0.0031799788121134043,
0.01906171813607216,
-0.018589714542031288,
-0.006157238036394119,
-0.01616917923092842,
0.03243517875671387,
-0.04390851780772209,
0.05315496399998665,
-0.013663924299180508,
-0.004202655050903559,
-0.022583598271012306,
0.01257468294352293,
-0.007025605067610741,
0.02742467075586319,
-0.03291928768157959,
-0.02240205928683281,
-0.023987509310245514,
-0.0013252432690933347,
-0.013385563157498837,
0.019170643761754036,
0.016532259061932564,
0.006577806081622839,
-0.012840942479670048,
-0.001975762192159891,
0.011624623090028763,
-0.016859032213687897,
0.000547646195627749,
0.015346196480095387,
0.010365944355726242,
-0.013506589457392693,
-0.015092040412127972,
-0.0038335234858095646,
0.00471701892092824,
-0.003016592701897025,
0.027521491050720215,
-0.035291410982608795,
-0.012671505101025105,
-0.03330657258629799,
0.015382505021989346,
-0.009107265621423721,
0.005234408657997847,
0.014777370728552341,
0.020501937717199326,
-0.06443466246128082,
0.012320526875555515,
-0.003006002865731716,
0.028465500101447105,
-0.014293263666331768,
-0.007648893166333437,
0.01989680342376232,
0.014559522271156311,
-0.014390084892511368,
0.03158799186348915,
-0.044707294553518295,
0.07372952252626419,
0.0017609397182241082,
0.006226828321814537,
-0.025246188044548035,
-0.017282625660300255,
-0.025367215275764465,
-0.0056731305085122585,
0.005231382790952921,
-0.017512576654553413,
0.02177271991968155,
0.011951395310461521,
0.014607933349907398,
0.0065657030791044235,
0.0047200447879731655,
-0.02534301020205021,
0.014039107598364353,
-0.004426554776728153,
0.025996554642915726,
-0.01320402231067419,
0.014486906118690968,
0.021639589220285416,
-0.0149105004966259,
0.009597424417734146,
-0.010226763784885406,
-0.014293263666331768,
-0.021990567445755005,
-0.014668446965515614,
-0.014353777281939983,
0.048241276293992996,
0.025173570960760117,
-0.0008365976973436773,
0.0015203990042209625,
0.04025350883603096,
0.037687741219997406,
0.032072097063064575,
0.042674046009778976,
0.025802910327911377,
0.005358460824936628,
-0.042189937084913254,
0.003394801402464509,
-0.0076307388953864574,
0.04526401683688164,
-0.045651305466890335,
-0.03323395550251007,
-0.006747243460267782,
-0.010674562305212021,
-0.006620165426284075,
0.0035218794364482164,
0.027666723355650902,
0.03667111694812775,
-0.004532453138381243,
-0.050976481288671494,
0.03209630399942398,
-0.01895279437303543,
0.0031103885266929865,
0.010244917124509811,
-0.014220647513866425,
-0.03894641995429993,
0.016701696440577507,
0.008175359107553959,
0.014414289966225624,
-0.00010277822002535686,
0.004099782556295395,
0.02467736229300499,
0.037760358303785324,
-0.035485055297613144,
-0.016253897920250893,
-0.0474667064845562,
0.0002097167307510972,
0.010438560508191586,
-0.017742527648806572,
0.0020362758077681065,
0.014341674745082855,
0.04221414402127266,
0.043690670281648636,
-0.02338237501680851,
-0.0005763900699093938,
0.04248040169477463,
-0.04340020567178726,
-0.030934447422623634,
-0.014741063117980957,
0.02378176338970661,
0.033016107976436615,
-0.04114910960197449,
-0.020550347864627838,
0.013881772756576538,
-0.008054332807660103,
-0.046038590371608734,
-0.041996296495199203,
0.0014114748919382691,
0.0003122112830169499,
0.029554741457104683,
-0.02170010283589363,
0.004946969915181398,
0.014269058592617512,
0.011400723829865456,
-0.011794060468673706,
0.025173570960760117,
-0.010759280994534492,
-0.015297786332666874,
-0.0032677233684808016,
-0.03887380287051201,
-0.011933241039514542,
-0.011273644864559174,
0.02628701739013195,
0.04226255416870117,
0.019013307988643646,
0.014547419734299183,
-0.0014621549053117633,
0.026867946609854698,
0.0182387363165617,
0.03350021317601204,
0.00634785508736968,
-0.017682014033198357,
-0.008980187587440014,
0.0329434908926487,
-0.029675768688321114,
-0.019436901435256004,
0.021119173616170883,
-0.0005642874166369438,
0.043763287365436554,
0.00819956511259079,
-0.011679084971547127,
-0.05397794768214226,
-0.006977194454520941,
0.012247910723090172,
0.053493838757276535,
-0.027594108134508133,
-0.04359384998679161,
-0.013676026836037636,
-0.01196349784731865,
0.007437095977365971,
0.020998148247599602,
0.01386967021971941,
0.011176823638379574,
0.01228421926498413,
0.007521814666688442,
0.020078344270586967,
0.014559522271156311,
0.008871263824403286,
-0.005933338310569525,
-0.006704884115606546,
-0.021203892305493355,
-0.018928589299321175,
0.03742148354649544,
0.004971175454556942,
-0.002369099296629429,
-0.01424485258758068,
-0.009518756531178951,
0.006021082866936922,
0.034274786710739136,
0.011285748332738876,
-0.008586850948631763,
-0.019981522113084793,
0.01652015559375286,
0.008381105028092861,
0.012949866242706776,
-0.0026293068658560514,
0.01643543690443039,
0.0015899894060567021,
-0.030159875750541687,
-0.0069227321073412895,
-0.014620035886764526,
0.003002977231517434,
0.011794060468673706,
0.02075609378516674,
-0.015455121174454689,
-0.02334606647491455,
0.00364290620200336,
-0.01890438422560692,
-0.011588314548134804,
0.0026035888586193323,
-0.006133032497018576,
-0.009161727502942085,
0.018105607479810715,
-0.006747243460267782,
0.013712335377931595,
-0.0019485312514007092,
0.003216286888346076,
-0.01902541145682335,
0.0035642387811094522,
-0.016338616609573364,
-0.015346196480095387,
-0.012223705649375916,
0.017766732722520828,
0.0009493038523942232,
0.003080131718888879,
-0.020586656406521797,
-0.02295878157019615,
0.0004572543257381767,
-0.04802342876791954,
0.041681624948978424,
-0.0014303853968158364,
-0.023999612778425217,
0.012623094022274017,
0.0012019473360851407,
0.010238866321742535,
0.015188861638307571,
0.011328107677400112,
-0.008350848220288754,
0.014196442440152168,
-0.005152715370059013,
0.015370401553809643,
0.0035037253983318806,
-0.018819665536284447,
-0.013579205609858036,
-0.0022662265691906214,
0.011164721101522446,
-0.019557928666472435,
0.009470346383750439,
0.01722211204469204,
-0.007533917669206858,
-0.0037427532952278852,
-0.011854574084281921,
0.023007191717624664,
0.012937763705849648,
-0.030692392960190773,
0.011176823638379574,
0.01753678172826767,
-0.018807562068104744,
-0.010523279197514057,
0.011158669367432594,
0.010214661248028278,
0.004172398708760738,
-0.005101278889924288,
0.012744120322167873,
-0.003167876275256276,
-0.016447540372610092,
0.01196349784731865,
-0.020344603806734085,
0.05325178802013397,
-0.023200836032629013,
-0.04463467746973038,
0.05441364273428917,
0.029215866699814796,
0.003040798008441925,
0.007612585090100765,
-0.02385438047349453,
-0.017863553017377853,
0.000720109383109957,
-0.010892410762608051,
0.004704916384071112,
-0.001609656261280179,
-0.05170264467597008,
0.01746416464447975,
0.022160004824399948,
-0.03166060894727707,
-0.002853206591680646,
0.021675897762179375,
0.01320402231067419,
-0.0010673049837350845,
0.021748512983322144,
-0.027981393039226532,
-0.0020029933657497168,
0.0029863358940929174,
0.02589973248541355,
0.03761512413620949,
0.02460474520921707,
0.0016852980479598045,
0.03550925850868225,
-0.012502066791057587,
-0.015334093943238258,
-0.0027775648050010204,
0.009385627694427967,
0.005473436322063208,
-0.03318554535508156,
-0.0714058056473732,
-0.0046020434238016605,
0.017391549423336983,
0.008483977988362312,
0.010311482474207878,
-0.006789602804929018,
-0.0011989215854555368,
0.009210138581693172,
-0.006959040183573961,
-0.026553276926279068,
0.014414289966225624,
-0.010898462496697903,
-0.00319813285022974,
-0.01228421926498413,
-0.002701923018321395,
-0.03512197360396385,
0.014305366203188896,
-0.005010508932173252,
0.03507356345653534,
-0.0040059867314994335,
0.009288805536925793,
0.011757752858102322,
-0.002653512405231595,
-0.018771255388855934,
-0.027787750586867332,
-0.01541881263256073,
-0.03354862704873085,
0.013288740999996662,
-0.03817185014486313,
-0.012961968779563904,
0.008786545135080814,
-0.03381488472223282,
-0.01714949496090412,
-0.019473209977149963,
0.03342759981751442,
-0.01835976354777813,
0.02366073615849018,
0.013421870768070221,
-0.014874191954731941,
-0.013155612163245678,
0.01874704845249653,
0.023043500259518623,
-0.0018622997449710965,
0.019787879660725594,
0.01883176900446415,
-0.0008222257602028549,
0.013082996010780334,
0.011382569558918476,
-0.01184852235019207,
-0.0016505027888342738,
-0.023999612778425217,
-0.005812311545014381,
-0.044271599501371384,
0.014220647513866425,
0.010571690276265144,
0.017282625660300255,
0.01907382160425186,
0.007939357310533524,
0.025560857728123665,
-0.015237272717058659,
0.0005813068128190935,
-0.0014954372309148312,
0.02330975979566574,
0.018976999446749687,
0.011061848141252995,
0.04064079374074936,
-0.01953372359275818,
0.002537023974582553,
-0.010607997886836529,
0.004798712208867073,
-0.007213196717202663,
-0.008520285598933697,
0.06307916343212128,
0.01632651314139366,
-0.022619906812906265,
-0.01100738625973463,
-0.010347790084779263,
-0.011182875372469425,
-0.0015597327146679163,
0.019364286214113235,
0.04156059771776199,
0.03328236564993858,
0.000024228995243902318,
-0.018117710947990417,
0.011570161208510399,
0.019400594756007195,
0.011588314548134804,
-0.003201158484444022,
0.006102775689214468,
-0.027448875829577446,
0.04005986824631691,
0.011346261017024517,
0.028344472870230675,
-0.009512705728411674,
-0.016967955976724625,
0.022886166349053383,
-0.006608062423765659,
-0.014135928824543953,
0.032822463661432266,
0.03393591195344925,
0.024725772440433502,
-0.018020888790488243,
0.046595312654972076,
0.029675768688321114,
-0.013167714700102806,
0.0024159972090274096,
-0.025730295106768608,
-0.011703290045261383,
-0.008508183062076569,
-0.0004099782381672412,
0.003213261254131794,
0.0012458194978535175,
-0.018650228157639503,
-0.00467768544331193,
-0.020223576575517654,
-0.01541881263256073,
-0.01678641512989998,
-0.01601184345781803,
0.01058984361588955,
0.00945219211280346,
-0.0278603658080101,
-0.04608700051903725,
-0.01469265203922987,
0.004462862852960825,
-0.04194788634777069,
-0.015443017706274986,
-0.015176759101450443,
0.024786286056041718,
0.05906107276678085,
0.005270716734230518,
0.0027427696622908115,
0.04528822377324104,
0.04359384998679161,
-0.01750047318637371,
0.03291928768157959,
0.040350329130887985,
0.0004232155333738774,
-0.013893875293433666,
-0.05271926894783974,
-0.016810620203614235,
-0.003406904172152281,
0.02334606647491455,
-0.006426522508263588,
0.009857632219791412,
0.023672839626669884,
-0.009803169406950474,
0.004520350601524115,
0.003419006709009409,
-0.01914643868803978,
0.001065035699866712,
-0.010795589536428452,
0.00079348188592121,
-0.008272181265056133,
0.005909132771193981,
-0.02212369628250599,
-0.007721508853137493,
0.02464105375111103,
-0.011933241039514542,
0.019279567524790764,
0.03417796641588211,
0.04071341082453728,
-0.02817503549158573,
-0.010117839090526104,
0.015285682864487171,
0.029240071773529053,
-0.0015915022231638432,
0.013034584932029247,
-0.010989231988787651,
-0.013095098547637463,
-0.00488645676523447,
0.03754251077771187,
0.008786545135080814,
-0.0365016795694828,
0.001951557002030313,
-0.0007511224830523133,
-0.009131470695137978,
0.008677620440721512,
0.047103624790906906,
0.012272115796804428,
0.02558506280183792,
-0.007915152236819267,
-0.010142045095562935,
0.0019076847238466144,
0.01566086709499359,
-0.029554741457104683,
-0.02621440216898918,
0.0032525949645787477,
0.014644240960478783,
-0.0384381078183651,
0.003009028499945998,
0.007624687626957893,
0.003773010103031993,
0.009815272875130177,
0.014329571276903152,
-0.028199240565299988,
-0.0018063248135149479,
0.0006497625727206469,
0.00798171665519476,
-0.019436901435256004,
-0.03153958171606064,
-0.04095546528697014,
-0.02848970517516136,
-0.00634785508736968,
-0.023019295185804367,
-0.040156688541173935,
-0.0027518465649336576,
-0.032314151525497437,
-0.029942026361823082,
0.0041845012456178665,
0.020840812474489212,
-0.027061589062213898,
-0.01860181801021099,
-0.02875596471130848,
0.022849857807159424,
0.0035188538022339344,
0.035485055297613144,
-0.01143703144043684,
-0.018456585705280304,
0.00933721661567688,
0.01636282168328762,
-0.02268042042851448,
-0.018408173695206642,
-0.0029636435210704803,
0.033911705017089844,
-0.031128089874982834,
-0.004426554776728153,
0.05378430336713791,
0.0023812020663172007,
-0.006269187666475773,
0.019327977672219276,
-0.019799983128905296,
-0.00158696377184242,
0.03388750180602074,
0.02220841497182846,
-0.004617171827703714,
0.00281084724701941,
-0.034153759479522705,
-0.017863553017377853,
-0.022111594676971436,
0.02793298289179802,
-0.01121918298304081,
0.01153385266661644,
0.047611936926841736,
0.007763868197798729,
-0.0337422676384449,
0.013567103073000908,
-0.00042283732909709215,
-0.029675768688321114,
-0.010813743807375431,
0.00039522809674963355,
0.008145103231072426,
0.015116245485842228,
-0.05117012560367584,
0.024532129988074303,
-0.000546133378520608,
-0.00012669991701841354,
-0.007346326019614935,
-0.00504076573997736,
-0.025125160813331604,
0.022498879581689835,
-0.028973812237381935,
-0.01989680342376232,
0.008223770186305046,
-0.023430785164237022,
-0.03209630399942398,
0.02231733873486519,
-0.0007685201126150787,
0.0026414096355438232,
0.02868334949016571,
0.02036880888044834,
-0.01816612109541893,
-0.007709406316280365,
-0.019134335219860077,
-0.02294667810201645,
0.006650421768426895,
-0.004105833824723959,
-0.03628383204340935,
0.007043758872896433,
0.006904578302055597,
0.00015922586317174137,
0.022135799750685692,
0.030934447422623634,
-0.02443530783057213,
0.01406331267207861,
-0.01973946951329708,
0.012332629412412643,
0.0010045223170891404,
0.003794189775362611,
0.09198036044836044,
-0.002674692077562213,
-0.021663794293999672,
-0.02875596471130848,
-0.01478947326540947,
-0.018662329763174057,
0.014148031361401081,
-0.023672839626669884,
0.03204789385199547,
-0.002674692077562213,
0.023842277005314827,
0.01261099148541689,
0.007418942172080278,
0.042819276452064514,
0.012526272796094418,
-0.007170837372541428,
-0.009676091372966766,
0.006638319231569767,
-0.03986622393131256,
-0.01247786171734333,
0.0024477667175233364,
0.014620035886764526,
-0.011951395310461521,
0.02205108106136322,
-0.0005831978050991893,
-0.020187268033623695,
-0.017488371580839157,
-0.030159875750541687,
-0.010214661248028278,
-0.020465629175305367,
-0.003204184118658304,
0.012683607637882233,
0.016411231830716133,
0.005176920909434557,
0.01683482527732849,
-0.01627810299396515,
-0.01608446054160595,
-0.03596916049718857,
0.01678641512989998,
0.02534301020205021,
0.00038577287341468036,
0.014365879818797112,
0.017439959570765495,
-0.004632300231605768,
0.011606468819081783,
-0.0016656311927363276,
-0.030619777739048004,
-0.02894960716366768,
-0.003034746740013361,
-0.01238104049116373,
0.01418433990329504,
0.025754500180482864,
0.009561115875840187,
0.013361357152462006,
-0.005313076078891754,
0.009252497926354408,
0.030305108055472374,
-0.011158669367432594,
-0.007061913143843412,
-0.031878456473350525,
-0.02259570173919201,
0.039019037038087845,
0.002558203646913171,
0.006765397265553474,
0.011636725626885891
] | 2024-07-12 | 47 | 38994929 | [
"CAR T cell therapy",
"mCAR T cells",
"radiation dose optimization",
"GBM",
"Gy",
"tumor growth kinetics",
"titrated doses",
"enhanced antitumor activity",
"TME",
"superior memory responses",
"combination",
"gene expression changes",
"Radiation",
"Glioblastoma Multiforme",
"10 Gy activates innate and adaptive immune cells",
"Murine immunocompetent models",
"stereotactic radiosurgery",
"10 Gy plus mCAR T cells",
"IL13Rα2",
"low-dose 10 Gy radiation",
"IL13Rα2-negative tumors",
"care",
"IL13Rα2-positive tumors",
"adjuvant chemoradiation",
"the immunosuppressive tumor microenvironment",
"A conditioning dose",
"great promise",
"part",
"CAR",
"rechallenge"
] | [
"CAR T cell therapy",
"IL13Rα2",
"c-GAS-STING pathway",
"glioblastoma",
"radiation",
"tumor microenvironment"
] | 0 | 10.3390/cells13131075
10.1200/jco.2017.73.0119
10.1016/s0167-8140(02)00078-6
10.1016/j.ijrobp.2009.04.054
10.1016/j.ijrobp.2004.04.011
10.1038/nrclinonc.2016.211
10.1158/1078-0432.Ccr-14-2824
10.4049/jimmunol.174.12.7516
10.4049/jimmunol.1200563
10.1084/jem.20052494
10.1016/j.ijrobp.2012.12.025
10.1200/JCO.2018.78.2276
10.1093/neuonc/nox036.071
10.1001/jamaoncol.2020.0857
10.1093/annonc/mdw367.34
10.1093/neuonc/noab196.217
10.1016/j.ymthe.2016.10.020
10.1056/NEJMoa1709866
10.1001/jamaoncol.2017.0184
10.1056/NEJMoa1610497
10.1038/s41467-020-17175-8
10.1126/scitranslmed.aaa0984
10.21203/rs.3.rs-3117663/v1
10.1158/2159-8290.Cd-20-1661
10.1080/2162402x.2020.1757360
10.1038/79075
10.7759/cureus.18480
10.4103/0973-1482.199537
10.1038/s41467-018-06182-5
10.1126/scisignal.2002657
10.1186/s13045-020-00916-z
10.1111/j.1349-7006.2006.00208.x
10.1158/1078-0432.Ccr-17-1766
10.1073/pnas.1910856117
10.1093/neuonc/noz015
10.4161/2162402x.2014.994374
10.1093/neuonc/noac099
10.1126/science.1087262
10.1016/j.ymthe.2018.09.008
10.1371/journal.pone.0032542
10.3389/fonc.2014.00032
10.1038/nature14426
10.1182/blood-2013-02-486217
10.1155/2015/983698
10.1158/0008-5472.Can-05-4005
10.1016/j.omto.2020.12.011
10.1007/s00262-013-1506-7
10.1158/0008-5472.Can-10-2820
10.1016/j.ijrobp.2020.02.016
10.1158/0008-5472.CAN-14-3619
10.1038/s41467-019-13094-5 | [
"Akhavan",
"Subham",
"Jeppson",
"Aguilar",
"Wong",
"Hibbard",
"Hui",
"Wong",
"Forman",
"Alizadeh",
"Brown"
] | [
"Department of Radiation Oncology, University of Kansas Cancer Center, Kansas City, KS 66160, USA.\nDepartment of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Cancer Center, Kansas City, KS 66160, USA.\nDepartment of Cancer Biology, University of Kansas Cancer Center, Kansas City, KS 66160, USA.\nBioengineering Program, University of Kansas, Lawrence, KS 66045, USA.\nDepartment of Immuno-Oncology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.\nDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.\nDepartment of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.",
"Department of Radiation Oncology, University of Kansas Cancer Center, Kansas City, KS 66160, USA.\nDepartment of Cancer Biology, University of Kansas Cancer Center, Kansas City, KS 66160, USA.\nBioengineering Program, University of Kansas, Lawrence, KS 66045, USA.",
"Department of Radiation Oncology, University of Kansas Cancer Center, Kansas City, KS 66160, USA.",
"Department of Immuno-Oncology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.\nDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.",
"Department of Immuno-Oncology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.\nDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.",
"Department of Immuno-Oncology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.\nDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.",
"Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.",
"Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.",
"Department of Immuno-Oncology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.\nDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.",
"Department of Immuno-Oncology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.\nDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.",
"Department of Immuno-Oncology, City of Hope Beckman Research Institute, Duarte, CA 91010, USA.\nDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA."
] | [
"38994929",
"28640706",
"12242114",
"19695794",
"15465203",
"28094262",
"25869387",
"15944250",
"22685313",
"16636135",
"23462419",
"30557521",
"32437542",
"28129122",
"29385370",
"28426845",
"28029927",
"32669548",
"28724573",
"33837065",
"32923113",
"10973261",
"34754642",
"28169234",
"30333482",
"22510470",
"32571374",
"16734735",
"29162646",
"31879345",
"30668768",
"25949916",
"35419607",
"12855817",
"30415658",
"22396773",
"24600588",
"25901682",
"23645836",
"26819959",
"16423985",
"33575480",
"24357146",
"21300764",
"32068114",
"26567136",
"31704921"
] | [] | 10.13217 | 7.466465 |
38993780 | 736 | invariant Natural Killer T cell therapy as a novel therapeutic approach in hematological malignancies. | Invariant Natural Killer T cell therapy is an emerging platform of immunotherapy for cancer treatment. This unique cell population is a promising candidate for cell therapy for cancer treatment because of its inherent cytotoxicity against CD1d positive cancers as well as its ability to induce host CD8 T cell cross priming. Substantial evidence supports that iNKT cells can modulate myelomonocytic populations in the tumor microenvironment to ameliorate immune dysregulation to antagonize tumor progression. iNKT cells can also protect from graft-versus-host disease (GVHD) through several mechanisms, including the expansion of regulatory T cells (Treg). Ultimately, iNKT cell-based therapy can retain antitumor activity while providing protection against GVHD simultaneously. Therefore, these biological properties render iNKT cells as a promising "off-the-shelf" therapy for diverse hematological malignancies and possible solid tumors. Further the introduction of a chimeric antigen recetor (CAR) can further target iNKT cells and enhance function. We foresee that improved vector design and other strategies such as combinatorial treatments with small molecules or immune checkpoint inhibitors could improve CAR iNKT | [
-0.016584565863013268,
0.012624555267393589,
0.008470321074128151,
0.03256487846374512,
0.003409709082916379,
-0.02818405069410801,
-0.00022878634626977146,
0.03554297983646393,
0.002515469677746296,
0.03614722937345505,
0.03111898899078369,
0.019163427874445915,
-0.039772745221853256,
0.011523952707648277,
0.03426973149180412,
-0.021418582648038864,
0.022443654015660286,
0.017275139689445496,
0.020728008821606636,
0.06288538873195648,
0.01921737939119339,
0.018926043063402176,
0.021796241402626038,
-0.0042918091639876366,
-0.005384318996220827,
-0.013358290307223797,
0.005273719318211079,
-0.0024844477884471416,
0.0009320051176473498,
-0.01582925021648407,
0.03955693915486336,
-0.01234400924295187,
-0.03765786066651344,
-0.005451757926493883,
0.02097618393599987,
0.018645497038960457,
0.05951884388923645,
0.019789259880781174,
-0.054037414491176605,
0.011880029924213886,
0.037032030522823334,
0.004178511910140514,
0.0006939459126442671,
0.06625194102525711,
-0.06275591254234314,
-0.018688658252358437,
-0.00486908620223403,
-0.03534875437617302,
-0.005778161808848381,
-0.02494698390364647,
0.00040058683953247964,
0.0010850912658497691,
-0.022055206820368767,
0.03537033498287201,
-0.06301487237215042,
0.06625194102525711,
-0.027061866596341133,
0.0173722505569458,
-0.023134227842092514,
0.018159937113523483,
-0.011286567896604538,
-0.0310974083840847,
0.04583684727549553,
0.00237789424136281,
-0.03923323377966881,
-0.014588374644517899,
-0.04240555688738823,
-0.0007148519507609308,
-0.029284652322530746,
0.003323387121781707,
0.004604725632816553,
-0.03256487846374512,
-0.047563280910253525,
0.006452550645917654,
0.017167236655950546,
0.040484897792339325,
-0.01934686116874218,
-0.00941446516662836,
0.016962222754955292,
-0.04283716529607773,
0.06461182981729507,
-0.010941280983388424,
-0.00016126318951137364,
-0.036837805062532425,
-0.012689297087490559,
-0.013509353622794151,
0.0056109135039150715,
-0.014609955251216888,
-0.08817766606807709,
0.020706428214907646,
-0.025723880156874657,
-0.006797837559133768,
-0.04296664893627167,
0.06387808918952942,
-0.027363993227481842,
0.033320192247629166,
0.0005701956106349826,
-0.06828050315380096,
-0.004882573615759611,
0.03230591490864754,
0.020134547725319862,
0.0027622957713901997,
-0.010801008902490139,
-0.012937471270561218,
0.054555345326662064,
-0.008254516869783401,
-0.028982525691390038,
0.01947634480893612,
0.01936844177544117,
0.02063089795410633,
0.04877178743481636,
-0.007304977625608444,
0.025119628757238388,
0.02505488693714142,
-0.02859407849609852,
-0.08295519649982452,
-0.020242448896169662,
0.007887649349868298,
0.019573455676436424,
0.008842583745718002,
-0.023306870833039284,
0.04562104120850563,
0.02742873504757881,
-0.00702982721850276,
-0.04296664893627167,
-0.047131672501564026,
0.05865562707185745,
0.0013824966736137867,
-0.039751164615154266,
-0.028917785733938217,
0.04177972674369812,
-0.005886063911020756,
0.003264040919020772,
-0.011826079338788986,
-0.0486854650080204,
-0.02483908273279667,
0.009252612479031086,
0.015419221483170986,
-0.00015578378224745393,
-0.011254197917878628,
0.008788633160293102,
-0.0431177131831646,
0.0030266561079770327,
0.007531572133302689,
-0.05166356638073921,
-0.03556456044316292,
0.002523562405258417,
0.011869240552186966,
0.03780892491340637,
0.01964898779988289,
-0.02136463299393654,
0.0497644878923893,
0.06784889101982117,
0.0008672638214193285,
-0.03478766232728958,
-0.009015227667987347,
-0.014329410158097744,
0.061288438737392426,
-0.013358290307223797,
-0.047304317355155945,
0.005859088618308306,
0.008319258689880371,
0.00028560360078699887,
-0.009279587306082249,
-0.023738481104373932,
0.018526805564761162,
-0.023350032046437263,
0.030234191566705704,
-0.05282890796661377,
0.03146427497267723,
-0.01205267384648323,
-0.05740395933389664,
-0.07242394238710403,
0.036535680294036865,
-0.05895775184035301,
-0.00808726903051138,
0.0173722505569458,
0.029694680124521255,
0.0006528082303702831,
0.004823227412998676,
0.00249658664688468,
0.03858581930398941,
0.0010021415073424578,
-0.0012219921918585896,
-0.00303205125965178,
0.043851446360349655,
-0.01240875106304884,
0.004143443889915943,
-0.06573400646448135,
-0.007666449993848801,
0.007402089890092611,
-0.007283397484570742,
0.025551237165927887,
0.06508659571409225,
0.0247743409126997,
-0.009516972117125988,
0.026759741827845573,
0.016562985256314278,
-0.0010237219976261258,
-0.0076988209038972855,
0.025767041370272636,
-0.020479833707213402,
-0.06676986813545227,
-0.006565847899764776,
0.008718496188521385,
0.008125034160912037,
-0.015883201733231544,
0.047174833714962006,
-0.00004699645796790719,
0.022573135793209076,
0.026651838794350624,
0.009538552723824978,
0.010962861590087414,
0.0484696589410305,
0.009209451265633106,
-0.029478875920176506,
-0.03826211392879486,
0.022087575867772102,
0.008864164352416992,
0.02134305238723755,
-0.016530614346265793,
-0.01222531683743,
-0.03120531141757965,
0.017296720296144485,
-0.0075423624366521835,
0.018008874729275703,
0.025227529928088188,
-0.0187641903758049,
-0.00705680251121521,
-0.033384934067726135,
-0.0313132144510746,
-0.00792541541159153,
0.040139611810445786,
-0.04115389287471771,
-0.08291203528642654,
-0.023026326671242714,
0.006927320268005133,
-0.01591557264328003,
0.026155488565564156,
-0.029673099517822266,
0.025745460763573647,
0.029370974749326706,
-0.0029673101380467415,
0.0050444272346794605,
-0.043225616216659546,
-0.012495072558522224,
-0.011232617311179638,
-0.05118879675865173,
-0.0069866664707660675,
-0.022918423637747765,
-0.02762295864522457,
0.036449357867240906,
0.013908591121435165,
-0.018667077645659447,
-0.0011356704635545611,
0.01042335107922554,
0.04158550128340721,
-0.009144710376858711,
-0.02483908273279667,
-0.032931745052337646,
0.03237065300345421,
-0.02462327852845192,
-0.033147551119327545,
-0.01765279658138752,
-0.08489743620157242,
-0.015278949402272701,
0.004558867309242487,
0.03370864316821098,
0.04303139075636864,
0.009678825736045837,
0.03601774945855141,
-0.02095460332930088,
0.02786034345626831,
-0.06396441161632538,
-0.04329035431146622,
0.03118373081088066,
-0.030708961188793182,
0.004958105273544788,
-0.015257368795573711,
0.0009758403757587075,
-0.022724200040102005,
-0.014750228263437748,
0.0009225636604242027,
-0.03901742771267891,
-0.025594398379325867,
-0.018429692834615707,
0.0027973640244454145,
0.02149411477148533,
-0.019746098667383194,
-0.08248043060302734,
0.01982163079082966,
0.019940324127674103,
-0.016055844724178314,
0.016897480934858322,
-0.006894949357956648,
0.026392873376607895,
-0.030277352780103683,
0.032694362103939056,
-0.009301167912781239,
0.03524085134267807,
-0.03847791999578476,
-0.02842143550515175,
0.018753400072455406,
-0.04544840008020401,
-0.001815454219467938,
0.01554870419204235,
0.014717857353389263,
-0.019033944234251976,
0.04262136295437813,
0.03733415529131889,
0.03161533921957016,
-0.025982845574617386,
-0.0018788467859849334,
0.039902228862047195,
0.0034258943051099777,
-0.01771753840148449,
0.0020042830146849155,
-0.05356264486908913,
-0.004672164563089609,
0.011351309716701508,
-0.033169131726026535,
-0.013110115192830563,
-0.030903184786438942,
0.022767361253499985,
0.023263711482286453,
-0.008885744959115982,
0.05321735516190529,
-0.0036902546416968107,
0.05351948365569115,
0.001188947120681405,
0.023306870833039284,
-0.01971372961997986,
0.03120531141757965,
-0.00693271541967988,
-0.019983483478426933,
-0.02505488693714142,
-0.03455027937889099,
-0.03528401255607605,
-0.0073805092833936214,
-0.014167556539177895,
0.005244045983999968,
0.03849950060248375,
-0.018246259540319443,
0.040635962039232254,
-0.0041973949410021305,
-0.01786860078573227,
-0.03623355180025101,
0.04959184303879738,
-0.03146427497267723,
0.04484414681792259,
-0.0008915417711250484,
-0.0010918352054432034,
0.023350032046437263,
0.008934300392866135,
-0.006921925116330385,
0.02503330633044243,
0.00870770588517189,
-0.0570586733520031,
-0.0010938583873212337,
0.004065214656293392,
-0.033384934067726135,
-0.004480638075619936,
-0.018483644351363182,
0.0386073999106884,
0.03562930226325989,
0.007720401044934988,
-0.01956266537308693,
0.0252059493213892,
-0.06452550739049911,
-0.04454202204942703,
0.003655186388641596,
0.00014870268933009356,
0.00938209518790245,
0.013757528737187386,
-0.010180571116507053,
0.019206589087843895,
0.03508979082107544,
0.0025748158805072308,
0.026651838794350624,
-0.00404363451525569,
0.023350032046437263,
0.004518403671681881,
0.02395428530871868,
-0.03552139922976494,
-0.016142167150974274,
0.007580128498375416,
0.01904473453760147,
-0.03552139922976494,
-0.0866670310497284,
0.06430970132350922,
0.030406834557652473,
-0.057878728955984116,
0.018613126128911972,
-0.02069563791155815,
-0.019767679274082184,
0.058180857449769974,
-0.053951092064380646,
0.06784889101982117,
0.03601774945855141,
0.023652158677577972,
-0.029176749289035797,
-0.011070763692259789,
-0.03798156976699829,
-0.03578036278486252,
0.020771170035004616,
-0.0347445011138916,
0.054641664028167725,
0.0274503156542778,
0.03765786066651344,
-0.005772766657173634,
-0.02056615613400936,
0.017836229875683784,
0.029457295313477516,
0.0032802263740450144,
0.026263391599059105,
-0.047174833714962006,
-0.006425574887543917,
0.03944903612136841,
0.005681050010025501,
0.009101549163460732,
-0.000295719422865659,
-0.060899991542100906,
-0.00623135082423687,
-0.040161192417144775,
0.00985686480998993,
0.0023010140284895897,
0.03578036278486252,
0.009144710376858711,
-0.011459211818873882,
-0.06750360876321793,
0.0024412868078798056,
0.08463846892118454,
-0.026090748608112335,
-0.01435098983347416,
-0.01923895999789238,
0.033169131726026535,
-0.013617255724966526,
0.014372570440173149,
-0.033277034759521484,
0.04527575522661209,
-0.03949219733476639,
-0.04941919818520546,
-0.017728328704833984,
-0.03127005323767662,
0.03209010884165764,
0.0381757915019989,
-0.0031183729879558086,
0.006382414139807224,
-0.018753400072455406,
-0.06711515784263611,
0.009506182745099068,
0.021634386852383614,
0.0137251578271389,
-0.016897480934858322,
0.0037981567438691854,
-0.05170672759413719,
0.012797199189662933,
-0.04085176810622215,
-0.01610979624092579,
0.023803221061825752,
0.01077942829579115,
-0.026608677580952644,
0.00886955950409174,
-0.011523952707648277,
-0.03172324225306511,
0.030104709789156914,
0.0007647566962987185,
-0.00695969071239233,
0.005241348408162594,
-0.051318276673555374,
0.01604505442082882,
-0.030514737591147423,
0.005805137567222118,
-0.02140779234468937,
-0.005459850654006004,
0.06297171115875244,
0.03625513240695,
0.020350351929664612,
0.01617453806102276,
0.03191746398806572,
0.003787366673350334,
0.009268797934055328,
-0.03081686422228813,
-0.021569646894931793,
0.06266959011554718,
0.002721832599490881,
0.0010324890026822686,
0.010504277423024178,
-0.00606410251930356,
0.010239916853606701,
-0.014458892866969109,
-0.01593715324997902,
0.03124847263097763,
-0.006921925116330385,
-0.0030833049677312374,
0.021796241402626038,
0.04076544567942619,
-0.0050714025273919106,
-0.019886372610926628,
0.019832421094179153,
-0.021839402616024017,
0.01908789575099945,
0.008308468386530876,
0.023306870833039284,
0.05144776031374931,
0.01711328700184822,
0.013077744282782078,
0.03448553755879402,
-0.022767361253499985,
0.027256092056632042,
-0.036384616047143936,
0.030708961188793182,
0.0022376214619725943,
-0.007434460334479809,
-0.009409070014953613,
-0.036924127489328384,
-0.043204035609960556,
0.0014094723155722022,
-0.029241491109132767,
-0.020123757421970367,
0.006824812851846218,
0.012969842180609703,
-0.023026326671242714,
-0.004812437575310469,
0.009252612479031086,
-0.015451592393219471,
-0.03543507680296898,
-0.010703896172344685,
-0.04162866249680519,
-0.03455027937889099,
0.005025544203817844,
0.002791968872770667,
0.018969204276800156,
0.047563280910253525,
-0.01405965443700552,
-0.021860981360077858,
-0.026543937623500824,
0.00606410251930356,
-0.003067119512706995,
-0.01951950415968895,
0.04288032650947571,
0.009225636720657349,
0.030903184786438942,
-0.008108848705887794,
0.017598845064640045,
0.04890126734972,
-0.0028054567519575357,
-0.030147869139909744,
-0.018095195293426514,
0.033298615366220474,
0.008972066454589367,
-0.03534875437617302,
0.0007310372893698514,
0.015796879306435585,
0.022044416517019272,
0.0010034902952611446,
0.002886383328586817,
-0.0054005044512450695,
-0.003827829845249653,
0.035391915589571,
-0.03198220580816269,
-0.030234191566705704,
-0.03124847263097763,
-0.03847791999578476,
0.010633760131895542,
0.0006261698435992002,
0.0017196910921484232,
-0.007488411385565996,
-0.0340970903635025,
0.04674322530627251,
-0.0018114078557118773,
-0.018774980679154396,
-0.01035860925912857,
0.0006052638054825366,
0.04946235939860344,
-0.001677878899499774,
0.013671206310391426,
0.011351309716701508,
0.008114243857562542,
0.02449379488825798,
-0.019530294463038445,
0.013444611802697182,
-0.02101934514939785,
0.030428415164351463,
0.01569976843893528,
0.001166017958894372,
-0.04454202204942703,
-0.020447462797164917,
-0.009781332686543465,
-0.015753718093037605,
0.019573455676436424,
-0.01902315393090248,
0.02145095355808735,
-0.006269116885960102,
-0.044196732342243195,
0.017318300902843475,
-0.023479515686631203,
-0.011858450248837471,
0.02807614766061306,
-0.020134547725319862,
-0.0017520616529509425,
-0.004094887990504503,
-0.029068848118185997,
-0.033535998314619064,
-0.01615295745432377,
0.014383360743522644,
0.020296400412917137,
-0.023350032046437263,
0.009236427024006844,
0.0031210705637931824,
0.047520119696855545,
-0.0003779948456212878,
-0.007429065182805061,
0.023997444659471512,
0.01231163926422596,
-0.036557260900735855,
-0.0054005044512450695,
0.01589399203658104,
-0.0010830682003870606,
-0.02436431311070919,
-0.022378912195563316,
0.0106175746768713,
-0.025810202583670616,
-0.02475276030600071,
-0.011011417955160141,
-0.03802473098039627,
-0.00797936599701643,
-0.01921737939119339,
0.005063309799879789,
-0.0023509187158197165,
0.008421765640377998,
-0.022875262424349785,
-0.014545214362442493,
0.02747189626097679,
-0.02857249788939953,
-0.0561954565346241,
0.030557898804545403,
-0.011772127822041512,
0.0021553460974246264,
-0.003471752628684044,
-0.026371292769908905,
-0.006091078277677298,
-0.006711515597999096,
-0.0161961168050766,
0.04631161689758301,
-0.0007162007386796176,
-0.03513295203447342,
-0.011987932026386261,
0.03137795627117157,
-0.018343370407819748,
-0.008071083575487137,
-0.036341454833745956,
0.020965393632650375,
-0.04626845568418503,
0.018041245639324188,
0.009150105528533459,
0.022486815229058266,
0.0007472226279787719,
0.05373528599739075,
0.04186604544520378,
-0.016595356166362762,
-0.00792541541159153,
0.007439855486154556,
-0.012085044756531715,
-0.009765147231519222,
-0.022616297006607056,
0.01786860078573227,
0.011502373032271862,
-0.0008733333088457584,
-0.013811479322612286,
0.040118031203746796,
0.028960945084691048,
0.040549639612436295,
-0.01778228022158146,
-0.002696205861866474,
0.040614381432533264,
0.015451592393219471,
-0.02417008951306343,
-0.009975557215511799,
0.014145975932478905,
-0.013369080610573292,
-0.01939002238214016,
-0.003606630489230156,
-0.0497644878923893,
-0.01606663502752781,
0.00014853410539217293,
0.029155170544981956,
0.007407485041767359,
-0.008583618327975273,
-0.023738481104373932,
0.01226847805082798,
-0.028615659102797508,
-0.014383360743522644,
-0.023760059848427773,
-0.001688669202849269,
0.03595300763845444,
-0.007655659690499306,
0.0019907953683286905,
-0.01610979624092579,
-0.006522687152028084,
-0.008578223176300526,
0.027212930843234062,
-0.0011383680393919349,
-0.020048225298523903,
0.006042522378265858,
0.005338460672646761,
-0.0006278558284975588,
-0.006830208003520966,
0.013930171728134155,
0.0037172301672399044,
-0.0021796240471303463,
0.011448421515524387,
0.019120266661047935,
-0.003201997373253107,
-0.011022208258509636,
-0.011513163335621357,
0.00247230869717896,
0.02429957129061222,
-0.006403994746506214,
-0.0007802676409482956,
0.0019894465804100037,
0.005284509621560574,
0.016757208853960037,
0.005805137567222118,
0.04842649772763252,
0.05261310562491417,
-0.037010449916124344,
0.06495711207389832,
0.0045912377536296844,
-0.01797650381922722,
-0.007110754027962685,
-0.05990729108452797,
-0.01748015359044075,
-0.018159937113523483,
-0.01030465867370367,
0.019292909651994705,
-0.020220868289470673,
-0.016778789460659027,
-0.01389780081808567,
-0.025249110534787178,
0.030471576377749443,
-0.04162866249680519,
-0.014966032467782497,
0.00031072457204572856,
0.014782599173486233,
0.006738491356372833,
0.026630258187651634,
-0.023501096293330193,
0.016099005937576294,
-0.03964326158165932,
-0.025680718943476677,
0.005605518352240324,
-0.019918743520975113,
0.0025883035268634558,
0.007779747247695923,
-0.03262962028384209,
0.01765279658138752,
-0.021807031705975533,
-0.026328133419156075,
-0.009052992798388004,
-0.03824053332209587,
-0.019271329045295715,
0.017318300902843475,
0.012948261573910713,
0.017598845064640045,
0.02479592151939869,
0.0009205404785461724,
0.03424815461039543,
-0.010973651893436909,
0.022767361253499985,
0.0012671762378886342,
-0.010396375320851803,
-0.004084097687155008,
-0.03765786066651344,
-0.006867974065244198,
-0.018062826246023178,
-0.023997444659471512,
-0.016390342265367508,
0.005907644517719746,
0.03953535854816437,
0.0121713662520051,
-0.0315290167927742,
0.014491262845695019,
-0.029500456526875496,
0.033579159528017044,
0.000314433709718287,
-0.004877178464084864,
0.012818778865039349,
-0.03373022377490997,
-0.017685167491436005,
-0.029478875920176506,
0.035391915589571,
-0.003285621525719762,
0.02803298644721508,
-0.02462327852845192,
0.015710556879639626,
0.004175814334303141,
-0.06780572980642319,
0.0005964967422187328,
-0.015451592393219471,
0.01057441346347332,
-0.0011255546705797315,
-0.009241822175681591,
-0.030342094600200653,
-0.028831463307142258,
-0.0009454928804188967,
-0.03444237634539604,
0.003299109172075987,
0.009425255469977856,
0.03554297983646393,
-0.0049365246668457985,
0.011211036704480648,
-0.025810202583670616,
-0.004297204315662384,
-0.0484696589410305,
-0.00625293143093586,
0.021483324468135834,
0.0007175495265983045,
0.00794699601829052,
-0.030277352780103683,
0.06059786677360535,
-0.02807614766061306,
-0.0021324169356375933,
-0.015278949402272701,
-0.023997444659471512,
-0.018731819465756416,
-0.01205267384648323,
-0.009419860318303108,
-0.005675654858350754,
-0.03785208612680435,
0.043657224625349045,
0.008421765640377998,
-0.025119628757238388,
0.0061018685810267925,
-0.0034178015775978565,
-0.009355119429528713,
-0.010002532042562962,
0.007504596840590239,
0.004353852942585945,
0.0014971428317949176,
-0.003962707705795765,
-0.03750680014491081,
-0.020102176815271378,
-0.015710556879639626,
0.012354799546301365,
0.03923323377966881,
-0.026695000007748604,
0.03735573589801788,
-0.0381757915019989,
-0.04864230379462242,
-0.008777842856943607,
-0.007666449993848801,
0.011513163335621357,
0.010935885831713676,
0.06746044754981995,
0.0034960308112204075,
0.0283135324716568,
-0.015408432111144066,
0.03813263028860092,
0.025918103754520416,
0.0018707540584728122,
-0.014167556539177895,
-0.002020468469709158,
0.018181517720222473,
0.016649307683110237,
-0.022249430418014526,
-0.005273719318211079,
0.01941160298883915,
0.02516278810799122,
-0.0557638481259346,
0.007957786321640015,
0.011815289035439491,
-0.010763242840766907,
-0.013487773016095161,
-0.007634079549461603,
0.001327871228568256,
0.05326051637530327,
-0.020943813025951385,
-0.010169780813157558,
-0.014286248944699764,
0.011426840908825397,
0.013606465421617031,
0.005225163418799639,
-0.0053222752176225185,
-0.013563304208219051,
-0.015753718093037605,
-0.026608677580952644,
0.014663906767964363,
-0.04941919818520546,
-0.014329410158097744,
0.01563502661883831,
-0.021947303786873817,
0.009031413123011589,
-0.044196732342243195,
0.01585083082318306,
0.0011147643672302365,
-0.015332899987697601,
0.03530559316277504,
0.004558867309242487,
-0.021742289885878563,
-0.03120531141757965,
0.003239762969315052,
-0.013261178508400917,
0.017598845064640045,
0.026889223605394363,
0.016163747757673264,
0.0071593099273741245,
0.05369212478399277,
-0.015041564591228962,
0.003630908438935876,
-0.013735948130488396,
-0.011416050605475903,
-0.02054457552731037,
0.03150743618607521,
0.00059986871201545,
-0.01042335107922554,
0.01052046287804842,
0.06638142466545105,
0.014782599173486233,
-0.03444237634539604,
-0.033492837101221085,
0.00023603602312505245,
-0.008454135619103909,
0.0126029746606946,
0.010223731398582458,
0.006026336923241615,
-0.009344329126179218,
-0.008308468386530876,
-0.026910804212093353,
0.03157217800617218,
-0.0193036999553442,
-0.014825759455561638,
0.013401451520621777,
0.022076787427067757,
0.01951950415968895,
0.00018967180221807212,
0.023760059848427773,
0.002755552064627409,
-0.008901930414140224,
-0.022659458220005035,
-0.011653435416519642,
0.021440163254737854,
0.002263248199597001,
-0.03906058892607689,
0.004205487668514252,
0.043225616216659546,
0.002862105378881097,
-0.023867962881922722,
0.02490382455289364,
0.03929797559976578,
0.04171498492360115,
0.005767371505498886,
-0.005627098958939314,
0.022637877613306046,
0.0034366846084594727,
-0.018796559423208237,
0.037161510437726974,
-0.013013003394007683,
0.007520782295614481,
-0.032953325659036636,
-0.008734681643545628,
0.0012543628690764308,
-0.015095515176653862,
-0.014642326161265373,
-0.00022878634626977146,
0.02136463299393654,
0.03921165317296982,
-0.029306232929229736,
-0.033298615366220474,
0.033643901348114014,
-0.011534743010997772,
0.0057457913644611835,
0.00426753144711256,
0.003323387121781707,
0.009279587306082249,
0.022022835910320282,
0.007768956944346428,
0.005691840313374996,
-0.0006484246696345508,
0.023565836250782013,
0.012915891595184803,
0.05261310562491417,
-0.050714027136564255,
-0.015030774287879467,
-0.014480472542345524,
0.025594398379325867,
-0.00033584554330445826,
-0.004610120784491301,
-0.018602335825562477,
0.02460169792175293,
0.03420499339699745,
0.0020703731570392847,
-0.04924655705690384,
-0.030601058155298233,
0.020382722839713097,
-0.017685167491436005,
-0.0041029807180166245,
0.0027474593371152878,
-0.0011977142421528697,
0.03502504900097847,
-0.023306870833039284,
-0.008481111377477646,
0.03170166164636612,
-0.007261816877871752,
-0.037269413471221924,
-0.02827037125825882,
0.047304317355155945,
0.01939002238214016,
0.02408376708626747,
-0.012635345570743084,
-0.00010571041639195755,
0.036794643849134445,
0.030860023573040962,
0.0022672945633530617,
0.0014836550690233707,
-0.02423482947051525,
0.005192792508751154,
-0.017102496698498726,
-0.04132653772830963,
-0.011707386933267117,
0.00808726903051138,
-0.017879391089081764,
0.009840679354965687,
0.04158550128340721,
0.05010977387428284,
-0.01224689744412899,
0.015419221483170986,
-0.036514099687337875,
0.05192252993583679,
0.0033152946271002293,
0.026004426181316376,
0.014761018566787243,
0.015926362946629524,
0.008135824464261532,
-0.03554297983646393,
0.01405965443700552,
-0.007914625108242035,
0.043204035609960556,
0.02408376708626747,
-0.007536967284977436,
-0.03234907612204552,
-0.02809772826731205,
0.015073934569954872,
0.040894925594329834,
0.011340519413352013,
-0.008583618327975273,
-0.01947634480893612,
-0.025486495345830917,
0.002859407803043723,
0.022357331588864326,
0.018591545522212982,
0.00981370359659195,
0.02803298644721508,
0.04937603697180748,
0.0011228570947423577,
0.026263391599059105,
0.01630401983857155,
0.03487398475408554,
-0.01384385023266077,
-0.008950485847890377,
-0.03554297983646393,
-0.0002748133847489953,
-0.003193904645740986,
0.0020042830146849155,
-0.03234907612204552,
0.0315290167927742,
0.017922552302479744,
-0.0005556962569244206,
0.008497296832501888,
-0.02388954348862171,
-0.001641461974941194,
-0.012656926177442074,
-0.022594716399908066,
0.016832740977406502,
-0.007423670031130314,
0.00896667130291462,
-0.00985686480998993,
0.018343370407819748,
0.00623135082423687,
-0.020242448896169662,
0.029608359560370445,
0.009150105528533459,
0.0024089161306619644,
-0.011588694527745247,
-0.05015293508768082,
0.016886692494153976,
-0.026133907958865166,
-0.02507646754384041,
0.02410534769296646,
-0.021138038486242294,
0.01582925021648407,
-0.012041883543133736,
-0.014761018566787243,
-0.005295299459248781,
-0.01685432158410549,
-0.01396254263818264,
-0.010180571116507053,
0.0025748158805072308,
0.03120531141757965,
-0.0193036999553442,
0.014437312260270119,
-0.013444611802697182,
0.020814331248402596,
-0.026846062391996384,
-0.043873026967048645,
0.05869878828525543,
-0.006787047255784273,
-0.025939684361219406,
-0.019422393292188644,
0.007768956944346428,
-0.016929851844906807,
-0.0009529111557640135,
0.005540776997804642,
0.0032532508485019207,
0.009166290052235126,
0.016724837943911552,
-0.007375114131718874,
-0.00436464324593544,
-0.01578608900308609,
0.014480472542345524,
-0.011685806326568127,
-0.019336070865392685,
-0.030255772173404694,
0.03163691982626915,
-0.01698380336165428,
0.015073934569954872,
-0.005152329336851835,
0.014502053149044514,
0.009311958216130733,
-0.0011161131551489234,
-0.002127021783962846,
0.009775937534868717,
0.010466511361300945,
-0.0013582187239080667,
-0.0006818069377914071,
-0.005508406553417444,
0.021526485681533813,
-0.028917785733938217,
0.00622595613822341,
0.012775618582963943,
-0.0006116704898886383,
0.010218336246907711,
-0.010655340738594532,
0.006430970039218664,
0.026867642998695374,
-0.002953822258859873,
-0.005252138711512089,
0.04277242347598076,
-0.007202470675110817,
-0.04251345992088318,
0.05347632244229317,
0.001459377002902329,
-0.0015322109684348106,
0.04441253840923309,
-0.010083459317684174,
0.0009070527157746255,
0.01900157518684864,
0.0033260846976190805,
-0.006020941771566868,
0.02786034345626831,
0.0017035057535395026,
-0.00012189574772492051,
0.03116215020418167,
-0.0041029807180166245,
-0.007261816877871752,
-0.009214846417307854,
-0.011912400834262371,
0.026414453983306885,
0.028745140880346298,
-0.044110413640737534,
-0.012085044756531715,
-0.0010594645282253623,
0.001413518562912941,
0.03515453264117241,
0.029435714706778526,
-0.004316087346524,
0.025141209363937378,
0.022875262424349785,
-0.026759741827845573,
0.0013487773248925805,
0.006635984405875206,
0.018246259540319443,
-0.03139953687787056,
-0.047563280910253525,
-0.009689616039395332,
0.008243726566433907,
0.007844489067792892,
-0.0061396341770887375,
-0.027407154440879822,
0.018235469236969948,
-0.019810840487480164,
-0.021526485681533813,
0.005702630151063204,
-0.00985686480998993,
-0.0015133280539885163,
0.002101395046338439,
0.02393270470201969,
-0.03144269436597824,
0.004111072979867458,
0.007790537551045418,
-0.0033611529506742954,
0.01702696457505226,
0.00963026937097311,
0.02451537549495697,
0.016476662829518318,
0.010202151723206043,
0.017965713515877724,
-0.012635345570743084,
0.012980632483959198,
-0.040528059005737305,
-0.0005968339391984046,
-0.00010815507994266227,
0.01645508222281933,
0.00709996372461319,
-0.029824163764715195,
-0.0038628980983048677,
-0.021936513483524323,
-0.0014903988922014832,
-0.009668035432696342,
0.025551237165927887,
0.0014823062811046839,
-0.03819737210869789,
0.0240190252661705,
-0.0008935649530030787,
0.0022672945633530617,
0.0017965713050216436,
0.028853043913841248,
0.022227849811315536,
0.008901930414140224,
0.013876221142709255,
-0.00222818017937243,
-0.03185272589325905,
0.023781640455126762,
-0.0075153871439397335,
-0.016800370067358017,
-0.013066953979432583,
0.00514153903350234,
-0.005419387016445398,
0.03252171725034714,
0.0484696589410305,
0.005913039669394493,
0.004442872479557991,
-0.036427777260541916,
-0.017469363287091255,
-0.022875262424349785,
-0.015084724873304367,
0.02818405069410801,
0.023695319890975952,
0.03455027937889099,
-0.007601708639413118,
-0.0017884786939248443,
-0.015257368795573711,
0.015537913888692856,
-0.05917355790734291,
0.010536648333072662,
0.0043700383976101875,
0.008157405070960522,
-0.05282890796661377,
-0.006760071963071823,
-0.0005884040729142725,
0.03256487846374512,
-0.005589332897216082,
0.018667077645659447,
-0.013692786917090416,
-0.0012172715505585074,
-0.036880966275930405,
0.022227849811315536,
-0.00986765418201685,
-0.0034285918809473515,
0.00307790981605649,
0.009182475507259369,
0.02395428530871868,
-0.022529976442456245,
0.03478766232728958,
0.01702696457505226,
-0.0010628364980220795,
-0.009365909732878208,
-0.02052299492061138,
0.028982525691390038,
-0.02084670215845108,
0.012678506784141064,
0.004513008985668421,
0.018062826246023178,
-0.014318619854748249,
-0.07501360028982162,
0.025896523147821426,
0.006290697026997805,
0.009657245129346848,
-0.012570604681968689,
-0.032737523317337036,
0.0026827179826796055,
0.018483644351363182,
0.03284542262554169,
0.00974896177649498,
0.0018195005832239985,
0.02147253416478634,
-0.021893352270126343,
0.004402408841997385,
-0.000884797889739275,
-0.002596396254375577,
0.021310681477189064,
0.005403202027082443,
-0.004558867309242487,
-0.03172324225306511,
-0.07108595967292786,
0.0009070527157746255,
0.022163107991218567,
-0.015840040519833565,
0.008211355656385422,
-0.0024534258991479874,
-0.0001385025680065155,
0.025702299550175667,
-0.03927639499306679,
-0.011685806326568127,
0.04162866249680519,
0.0009084015036933124,
-0.02764453925192356,
-0.022724200040102005,
0.043700382113456726,
0.008254516869783401,
-0.03247855603694916,
-0.022810520604252815,
-0.000930656329728663,
-0.02807614766061306,
0.014264668338000774,
-0.004086795262992382,
0.005106471013277769,
0.043937768787145615,
0.00790383480489254,
0.01967056840658188,
-0.021699128672480583,
-0.03262962028384209,
-0.0035122160334140062,
-0.036600422114133835,
0.003933034371584654,
0.008076478727161884,
-0.026133907958865166,
-0.020857492461800575,
0.010342423804104328,
0.03483082354068756,
-0.002827037125825882,
-0.006263721734285355,
0.022918423637747765,
0.03511137142777443,
0.0014216112904250622,
0.014372570440173149,
0.012559814378619194,
0.028960945084691048,
0.001377101638354361,
0.002789271529763937,
-0.012473491951823235,
0.016973013058304787,
0.0030833049677312374,
0.009241822175681591,
0.00856743287295103,
-0.028982525691390038,
0.012786408886313438,
-0.0017021569656208158,
-0.013563304208219051,
0.004548077005892992,
0.012441121973097324,
0.011621065437793732,
-0.004356550518423319,
0.008254516869783401,
-0.01572134718298912,
-0.06003677472472191,
-0.020479833707213402,
-0.04206027090549469,
-0.01791176199913025,
-0.036924127489328384,
0.00026452893507666886,
-0.01954108476638794,
-0.013595675118267536,
0.0012739201774820685,
0.016681676730513573,
-0.03772260248661041,
-0.02783876284956932,
0.011998722329735756,
0.006948900409042835,
-0.006938110571354628,
0.006479525938630104,
-0.029133589938282967,
-0.03534875437617302,
0.01730751059949398,
-0.0010075366590172052,
-0.01687590219080448,
-0.005718815606087446,
-0.058094535022974014,
-0.006884159054607153,
0.029414134100079536,
-0.018246259540319443,
0.021839402616024017,
0.030255772173404694,
0.00486908620223403,
0.005686445161700249,
-0.01252744346857071,
0.0278819240629673,
0.007229446433484554,
0.004526496399194002,
0.016821950674057007,
-0.01891525276005268,
0.005074100103229284,
-0.026608677580952644,
0.016401132568717003,
-0.006258326582610607,
-0.03247855603694916,
0.005659469403326511,
-0.040549639612436295,
0.026587096974253654,
-0.027212930843234062,
0.022551557049155235,
0.009069178253412247,
0.020986974239349365,
-0.057965051382780075,
0.026716580614447594,
0.0017062032129615545,
0.0004626306181307882,
0.05010977387428284,
0.030644219368696213,
-0.014458892866969109,
0.0046964422799646854,
0.032823845744132996,
0.03163691982626915,
-0.00961947999894619,
0.007666449993848801,
0.039902228862047195,
0.014070444740355015,
-0.03580194339156151,
0.022853681817650795,
0.018882881850004196,
-0.004634398967027664,
-0.015041564591228962,
-0.02811930887401104,
-0.017944132909178734,
0.029198329895734787,
-0.06443918496370316,
0.010132014751434326,
-0.006592823192477226,
-0.008432555943727493,
0.00004960971273249015,
0.026802903041243553,
-0.050714027136564255,
-0.018278630450367928,
-0.002241667825728655,
-0.006468735635280609,
0.012786408886313438,
-0.015386851504445076,
-0.01713486574590206,
0.014318619854748249,
0.011750548146665096,
-0.0006420179852284491,
0.033471256494522095,
0.0173722505569458,
0.0003493333060760051,
0.0086861252784729,
-0.029975226148962975,
-0.006058707367628813,
0.040398575365543365,
-0.011135505512356758,
0.0013865430373698473,
0.032953325659036636,
-0.007472225930541754,
0.015386851504445076,
0.032823845744132996,
0.03284542262554169,
-0.00623135082423687,
0.002056885277852416,
-0.018343370407819748,
0.043225616216659546,
-0.0037280204705893993,
-0.013692786917090416,
0.10125540941953659,
-0.030191030353307724,
0.0005789626738987863,
0.015073934569954872,
-0.022573135793209076,
0.033147551119327545,
0.04562104120850563,
-0.01248428225517273,
-0.011728967539966106,
-0.02492540329694748,
0.03420499339699745,
0.002561328001320362,
0.03439921513199806,
0.018364951014518738,
0.036967288702726364,
-0.008292282931506634,
-0.007752771954983473,
0.032823845744132996,
0.000832869962323457,
0.0027622957713901997,
-0.0002953822258859873,
0.021030135452747345,
-0.017426202073693275,
0.016487453132867813,
-0.010962861590087414,
0.02857249788939953,
0.011901610530912876,
-0.018008874729275703,
0.00702982721850276,
-0.016994593665003777,
0.018818140029907227,
0.004086795262992382,
0.0077150058932602406,
-0.033643901348114014,
-0.02101934514939785,
-0.01921737939119339,
-0.022486815229058266,
-0.010725476779043674,
0.00870770588517189,
0.016746418550610542,
0.0027069959323853254,
-0.011653435416519642,
-0.01425387803465128,
0.01419992744922638,
0.03146427497267723,
-0.0024777038488537073,
-0.01417834684252739,
0.004518403671681881,
0.033233873546123505,
-0.020123757421970367,
0.005627098958939314,
0.011264988221228123,
0.019336070865392685,
-0.023134227842092514,
-0.03221959248185158,
-0.022422073408961296,
0.03504662960767746,
-0.010126619599759579,
-0.010061878710985184,
-0.012689297087490559,
0.0006453899550251663,
0.014653116464614868,
0.029263071715831757,
-0.011448421515524387,
0.016778789460659027
] | 2024-07-12 | 203 | 38993780 | [
"iNKT cells",
"cell therapy",
"regulatory T cells",
"Invariant Natural Killer T cell therapy",
"iNKT",
"cancer treatment",
"CD1d positive cancers",
"combinatorial treatments",
"immune checkpoint inhibitors",
"cell-based therapy",
"possible solid tumors",
"immune dysregulation",
"diverse hematological malignancies",
"tumor progression",
"This unique cell population",
"myelomonocytic populations",
"other strategies",
"antitumor activity",
"vector design",
"several mechanisms",
"small molecules",
"host",
"Invariant Natural Killer",
"GVHD",
"Substantial evidence",
"CAR",
"immunotherapy",
"a chimeric antigen recetor",
"protection",
"the tumor microenvironment"
] | [
"acute myeloid leukemia",
"chimeric antigen receptor",
"graft vs. host disease",
"hematopoietic stem cell transplant (HSCT)",
"immune therapy",
"invariant natural killer T cell",
"microenvironment"
] | 0 | 10.3389/frtra.2024.1353803
10.1038/nri3369
10.3389/fmed.2022.897750
10.1182/blood-2014-05-576017
10.1016/j.tranon.2022.101342
10.1172/JCI83476
10.4049/jimmunol.1800429
10.1182/blood-2013-11-541235
10.1038/s41591-023-02363-y
10.1111/cas.14428
10.1158/1078-0432.CCR-21-1329
10.3389/fimmu.2018.00384
10.1084/jem.188.8.1521
10.1084/jem.192.5.741
10.1084/jem.191.11.1895
10.1016/S1471-4906(03)00179-0
10.1038/s41467-020-20073-8
10.1126/science.1216557
10.4049/jimmunol.0901059
10.1084/jem.20011786
10.1084/jem.20011908
10.1111/j.1365-2567.2007.02647.x
10.1002/eji.200939349
10.1038/nature03407
10.1038/ni1380
10.1038/nature03408
10.1021/jm00012a018
10.1016/j.clim.2010.11.010
10.1182/bloodadvances.2020003272
10.1002/eji.201546114
10.1200/JCO.2022.40.16_suppl.2582
10.4049/jimmunol.1401805
10.1046/j.1365-2567.2000.00001.x
10.1182/blood.2022016201
10.1309/AJCP2F2DOXOTXHZA
10.1038/sj.leu.2402943
10.12688/f1000research.21378.1
10.1182/blood.2021010887
10.3389/fimmu.2018.01393
10.1038/ni.3437
10.1016/j.immuni.2015.06.025
10.1038/s41577-018-0034-2
10.1084/jem.20050456
10.1016/j.coi.2016.01.001
10.1016/j.molimm.2018.09.023
10.3389/fimmu.2017.01950
10.1038/ni.1641
10.1016/j.immuni.2008.07.011
10.1371/journal.pbio.1001255
10.1146/annurev.immunol.21.120601.141057
10.1146/annurev.immunol.22.012703.104608
10.1038/nri1309
10.1146/annurev.immunol.25.022106.141711
10.1111/j.1600-065X.2012.01166.x
10.1126/science.1092009
10.1038/nature04001
10.1172/JCI40451
10.1126/science.291.5504.664
10.1126/science.1115301
10.1016/S0040-4020(01)86991-X
10.1126/science.278.5343.1626
10.1073/pnas.95.10.5690
10.1111/j.1365-2567.2004.02111.x
10.1146/annurev-immunol-101819-074948
10.1073/pnas.1332805100
10.4049/jimmunol.174.7.3864
10.1146/annurev.immunol.23.021704.115742
10.1002/eji.200526157
10.1038/ni827
10.1016/j.it.2019.09.008
10.1172/JCI24762
10.1146/annurev-immunol-032713-120243
10.1084/jem.20030630
10.4049/jimmunol.163.11.5871
10.4049/jimmunol.2000870
10.1371/journal.ppat.1000106
10.4049/jimmunol.181.7.4452
10.1016/j.clim.2011.04.017
10.4049/jimmunol.0802492
10.4049/jimmunol.178.5.2706
10.1002/eji.200838575
10.1093/intimm/dxn060
10.3389/fimmu.2023.1099529
10.3389/fimmu.2017.00570
10.1038/emboj.2012.87
10.1016/j.immuni.2013.12.004
10.1016/j.immuni.2007.08.017
10.1073/pnas.0710145104
10.1084/jem.20102555
10.1084/jem.20040317
10.4049/jimmunol.163.9.4647
10.1084/jem.20030324
10.1038/ni.1848
10.3389/fimmu.2018.02375
10.1016/j.celrep.2018.02.058
10.1073/pnas.0408288102
10.1038/ni.1853
10.1146/annurev-immunol-032414-112220
10.1073/pnas.1910412116
10.1038/s41590-021-00934-0
10.1074/jbc.M112.371807
10.1016/j.immuni.2012.06.016
10.1016/j.clim.2010.10.005
10.1038/nri3174
10.1073/pnas.0801631105
10.4049/jimmunol.160.7.3121
10.1073/pnas.0801375105
10.1182/blood-2008-06-166249
10.1073/pnas.1504790112
10.1084/jem.20021293
10.1038/s41467-018-02911-y
10.1093/rheumatology/keq457
10.1038/nm0602-588
10.1002/eji.200324254
10.1084/jem.20061097
10.1002/hep.26471
10.4049/jimmunol.1101273
10.1016/j.cyto.2010.04.016
10.1097/SHK.0000000000000553
10.1002/eji.200737838
10.1182/blood-2009-02-205492
10.1016/j.clim.2011.03.002
10.1182/blood-2011-11-389304
10.1038/sj.bmt.1704582
10.1038/bmt.2015.335
10.4049/jimmunol.1003748
10.4161/onci.27440
10.4049/jimmunol.1001018
10.1182/blood-2005-08-3103
10.4049/jimmunol.161.5.2217
10.1182/blood.V97.7.2067
10.1371/journal.pone.0065075
10.1371/journal.pone.0020702
10.1126/sciimmunol.abn6563
10.1182/blood-2016-11-751065
10.1189/jlb.0609385
10.1182/blood.V99.3.1030
10.1371/journal.pone.0011311
10.1158/0008-5472.CAN-15-2524
10.3389/fimmu.2021.715424
10.1182/blood-2014-11-612762
10.3389/fimmu.2017.00900
10.1038/s41409-019-0600-7
10.1084/jem.20042592
10.1016/j.clim.2011.01.009
10.1002/hep.21447
10.1186/s12967-017-1219-3
10.1084/jem.20070458
10.1073/pnas.0604812103
10.4161/2162402X.2014.990793
10.1182/blood-2012-04-426643
10.1182/blood-2014-04-568956
10.1038/s41571-020-0426-7
10.1038/s41573-023-00807-1
10.1016/S2352-3026(22)00245-9
10.1172/JCI42027
10.3390/cells10123497
10.1016/j.ccell.2018.08.017
10.3390/ijms22031096
10.1038/35040504
10.4049/jimmunol.178.5.2827
10.1021/bi0202023
10.1182/bloodadvances.2023010032
10.1158/2326-6066.CIR-19-0134
10.3389/fimmu.2021.744823
10.1038/d41573-023-00140-7
10.1038/s41375-020-0818-9
10.1182/blood-2018-99-112572
10.1182/blood-2015-11-679134
10.1038/s41572-023-00438-1
10.1038/nri2000
10.1016/j.bbmt.2005.09.004
10.1038/s41423-023-01022-z
10.1056/NEJMra1609337
10.1038/s41409-021-01389-5
10.1038/s41409-022-01881-6
10.1016/S1083-8791(03)00108-3
10.4049/jimmunol.178.10.6242
10.1182/blood-2010-08-303008
10.4049/jimmunol.174.1.551
10.1016/j.bbmt.2010.11.022
10.1182/blood-2008-06-165506
10.1182/blood-2011-08-371948
10.1111/ajt.12606
10.1182/blood-2016-11-752444
10.1084/jem.20020399
10.1038/nm915
10.1111/ajt.12914
10.1182/blood-2016-07-723015
10.4049/jimmunol.181.10.6923
10.1182/blood-2015-12-688739
10.1038/leu.2016.281
10.1182/blood-2012-01-404673
10.1182/blood-2009-03-211441
10.1016/j.bbmt.2017.01.069
10.3324/haematol.2020.267583
10.1182/blood.2019001903 | [
"Boonchalermvichian",
"Yan",
"Gupta",
"Rubin",
"Baker",
"Negrin"
] | [
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University, Stanford, CA, United States.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University, Stanford, CA, United States.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University, Stanford, CA, United States.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University, Stanford, CA, United States.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University, Stanford, CA, United States.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University, Stanford, CA, United States."
] | [
"38993780",
"23334244",
"35615083",
"25293774",
"35063813",
"27183388",
"30111631",
"25049283",
"37188782",
"32324315",
"34376537",
"29559971",
"9782129",
"10974039",
"10839805",
"12909453",
"33288744",
"22345399",
"19587013",
"11877485",
"11877486",
"17662044",
"19585513",
"15791257",
"16921381",
"21941292",
"15791258",
"7783149",
"21169066",
"12473579",
"34100904",
"26873393",
"25381357",
"10809957",
"36347021",
"21846915",
"12764370",
"29109728",
"32148771",
"34036317",
"29973936",
"27089380",
"26362265",
"29967365",
"16087715",
"26802287",
"30502719",
"29375573",
"18660811",
"18703361",
"22346732",
"12543936",
"15032598",
"15039760",
"17150027",
"23046129",
"14684827",
"16208376",
"20484813",
"11158680",
"16311334",
"9374463",
"9576945",
"15720435",
"33902312",
"12829795",
"15778340",
"15771592",
"15915536",
"12154358",
"31676264",
"16138194",
"24499274",
"14530376",
"10570271",
"33229442",
"18636102",
"18802047",
"21646050",
"19201836",
"17312112",
"19266498",
"18550585",
"37228593",
"28596767",
"22505026",
"24412610",
"17950005",
"18077358",
"21555485",
"15197224",
"10528160",
"12874260",
"20190758",
"30369933",
"29539427",
"15644449",
"20228797",
"25861979",
"31611396",
"34040226",
"22645141",
"22981538",
"21095162",
"22437937",
"18685112",
"9531266",
"18550809",
"18832653",
"26392556",
"12591906",
"29449556",
"21278064",
"12042809",
"14635040",
"17088433",
"23686838",
"22387552",
"20554220",
"26717105",
"18350544",
"19433855",
"21429807",
"21267014",
"22371885",
"15300228",
"26878658",
"21357532",
"24575380",
"20660713",
"16357323",
"9725214",
"11264173",
"23741460",
"21695190",
"35984893",
"28465341",
"34177968",
"19741157",
"11807009",
"20593019",
"26979791",
"31314221",
"34489966",
"28819653",
"25795920",
"28824628",
"31431709",
"15867097",
"21349771",
"17187419",
"28549432",
"17923500",
"16844772",
"25949907",
"22932803",
"25237205",
"32934330",
"37907724",
"36228643",
"20516640",
"34944002",
"30300581",
"33499253",
"11081504",
"17312126",
"12093291",
"37399471",
"31719055",
"34691052",
"28959944",
"37673977",
"32358567",
"26813675",
"37291149",
"17438575",
"16338616",
"37165014",
"29171820",
"34218265",
"36446899",
"12813443",
"17475852",
"21258007",
"15611282",
"21145405",
"19221040",
"22174155",
"24502294",
"28416503",
"12163567",
"12925844",
"34220860",
"25311657",
"28096089",
"18981112",
"26903546",
"27740636",
"22730537",
"19423725",
"28104514",
"33440919",
"31935280"
] | [] | 11.369642 | 5.686705 |
38987565 | 737 | Emerging roles of CAR-NK cell therapies in tumor immunotherapy: current status and future directions. | Cancer immunotherapy harnesses the body's immune system to combat malignancies, building upon an understanding of tumor immunosurveillance and immune evasion mechanisms. This therapeutic approach reactivates anti-tumor immune responses and can be categorized into active, passive, and combined immunization strategies. Active immunotherapy engages the immune system to recognize and attack tumor cells by leveraging host immunity with cytokine supplementation or vaccination. Conversely, passive immunotherapy employs exogenous agents, such as monoclonal antibodies (anti-CTLA4, anti-PD1, anti-PD-L1) or adoptive cell transfers (ACT) with genetically engineered chimeric antigen receptor (CAR) T or NK cells, to exert anti-tumor effects. Over the past decades, CAR-T cell therapies have gained significant traction in oncological treatment, offering hope through their targeted approach. However, the potential adverse effects associated with CAR-T cells, including cytokine release syndrome (CRS), off-tumor toxicity, and neurotoxicity, warrant careful consideration. Recently, CAR-NK cell therapy has emerged as a promising alternative in the landscape of tumor immunotherapy, distinguished by its innate advantages over CAR-T cell modalities. In this review, we will synthesize the latest research and clinical advancements in CAR-NK cell therapies. We will elucidate the therapeutic benefits of employing CAR-NK cells in oncology and critically examine the developmental bottlenecks impeding their broader application. Our discussion aims to provide a comprehensive overview of the current status and future potential of CAR-NK cells in cancer immunotherapy. | [
-0.011492460034787655,
0.029826940968632698,
0.01860174909234047,
0.05819995328783989,
-0.03207198157906532,
-0.00823715329170227,
0.00041827207314781845,
0.02268557995557785,
0.011353480629622936,
0.031173964962363243,
-0.004383170511573553,
-0.014378937892615795,
-0.014678276143968105,
0.001973763108253479,
0.01963874325156212,
-0.02935655228793621,
0.016089443117380142,
0.003044165438041091,
0.03619857504963875,
0.01148176845163107,
0.018120668828487396,
0.000625069544184953,
0.013416778296232224,
-0.011503150686621666,
-0.03942715376615524,
-0.021723421290516853,
-0.009931623004376888,
0.016730882227420807,
-0.04299783334136009,
-0.029997991397976875,
0.008258534595370293,
-0.01849484257400036,
-0.02895030751824379,
-0.007585023529827595,
0.01598253659904003,
0.016944697126746178,
0.035279177129268646,
0.000680193246807903,
-0.02914273925125599,
-0.009322255849838257,
0.04130871221423149,
0.015234190970659256,
0.004121249541640282,
0.10767632722854614,
-0.05862757936120033,
-0.014956233091652393,
0.0010283078299835324,
-0.07355174422264099,
0.006355597637593746,
-0.016292566433548927,
-0.014870707876980305,
-0.0011532549979165196,
-0.01933940500020981,
0.04464419558644295,
-0.05661773681640625,
0.039256103336811066,
-0.03929886594414711,
-0.006050913594663143,
-0.016399472951889038,
0.02537962608039379,
0.005596560426056385,
-0.017992381006479263,
0.024524373933672905,
-0.005358693189918995,
-0.053667113184928894,
-0.010161472484469414,
-0.025828635320067406,
-0.015918392688035965,
-0.02168065868318081,
0.02587139792740345,
0.04768034443259239,
-0.007905743084847927,
-0.00592262577265501,
0.02260005474090576,
0.035471610724925995,
-0.008408203721046448,
-0.01900799386203289,
0.00439920648932457,
0.023027682676911354,
-0.014998995698988438,
0.060038745403289795,
-0.006991691887378693,
0.0035760258324444294,
-0.012112517841160297,
0.0007744046743027866,
-0.029185501858592033,
-0.00541214644908905,
-0.024652661755681038,
-0.06765049695968628,
0.005102117545902729,
-0.0035626625176519156,
-0.0011853269534185529,
-0.02794538624584675,
0.03810151293873787,
-0.006911511532962322,
0.03433839976787567,
-0.022343479096889496,
-0.06311766058206558,
0.044729720801115036,
0.04218534380197525,
0.039640966802835464,
0.018484150990843773,
-0.019424930214881897,
0.009605557657778263,
0.055249329656362534,
0.027603283524513245,
-0.05520656704902649,
-0.017329560592770576,
0.032499607652425766,
0.021477535367012024,
0.043917231261730194,
-0.013726807199418545,
-0.014100980944931507,
0.027795715257525444,
-0.047423768788576126,
-0.06636761873960495,
-0.025251338258385658,
0.0071787782944738865,
0.004383170511573553,
0.010669278912246227,
-0.02448161132633686,
0.024118129163980484,
0.04378894343972206,
-0.0076865847222507,
-0.01451791636645794,
-0.02398984134197235,
0.050203338265419006,
0.0035172272473573685,
-0.033782485872507095,
-0.026299024000763893,
0.012796720489859581,
-0.007654512766748667,
0.006863403599709272,
-0.012668431736528873,
-0.07496290653944016,
-0.005388092715293169,
-0.03085324540734291,
-0.00792712438851595,
-0.006836676970124245,
-0.0028704421129077673,
0.02369050309062004,
-0.03981201723217964,
-0.0044446419924497604,
-0.02379740960896015,
-0.038764335215091705,
-0.049005985260009766,
0.009910241700708866,
0.013320562429726124,
0.006307489238679409,
0.059140730649232864,
-0.019029375165700912,
0.051999371498823166,
0.05165727064013481,
0.01642085425555706,
-0.014763801358640194,
-0.009637629613280296,
-0.0038914002943784,
0.06499921530485153,
-0.0360061414539814,
-0.042441919445991516,
-0.017789257690310478,
-0.0043083359487354755,
-0.005267822649329901,
-0.02277110517024994,
-0.013320562429726124,
-0.015191428363323212,
-0.019424930214881897,
0.009386399760842323,
-0.03880709782242775,
-0.0020846787374466658,
0.004482059273868799,
-0.04827902093529701,
-0.05379540100693703,
0.03140915930271149,
-0.03495845943689346,
-0.001457938808016479,
0.038550518453121185,
0.05165727064013481,
-0.028715113177895546,
-0.0002797946217469871,
-0.01443239115178585,
0.005438873078674078,
0.014154434204101562,
0.009969040751457214,
-0.03243546187877655,
0.030789101496338844,
0.017094366252422333,
0.027881242334842682,
-0.06008150801062584,
-0.02197999693453312,
-0.0020619609858840704,
-0.003306086640805006,
0.012048373930156231,
0.026299024000763893,
0.0013557092752307653,
-0.0017652952810749412,
0.004613019991666079,
0.002454842906445265,
-0.03014766052365303,
-0.020975075662136078,
0.04346822202205658,
-0.0397692546248436,
-0.05520656704902649,
0.0021501590963453054,
-0.00711463438346982,
-0.004182720556855202,
0.00031220068922266364,
0.02557205967605114,
-0.006344906520098448,
0.02835163101553917,
0.034381162375211716,
0.01810997724533081,
0.0034023025073111057,
0.04430209472775459,
-0.006339561194181442,
-0.036754488945007324,
-0.03284170851111412,
0.04041069373488426,
0.019809793680906296,
0.019424930214881897,
0.017725113779306412,
-0.013844404369592667,
-0.030169041827321053,
-0.016303256154060364,
-0.022942155599594116,
0.006077640224248171,
0.01923249661922455,
-0.029078595340251923,
0.014239959418773651,
-0.05807166546583176,
-0.028437156230211258,
0.027132894843816757,
0.04085970297455788,
-0.0015287643764168024,
-0.045713260769844055,
-0.029698653146624565,
0.005262477323412895,
-0.004578275140374899,
0.05623287335038185,
-0.018035143613815308,
0.034466687589883804,
0.018259648233652115,
-0.006932892836630344,
-0.013138821348547935,
-0.03739592805504799,
0.00400365237146616,
-0.009904896840453148,
-0.07586092501878738,
0.003137708641588688,
-0.022022759541869164,
-0.014047527685761452,
0.043211646378040314,
0.00038052067975513637,
-0.004083832260221243,
0.009969040751457214,
0.005021937657147646,
0.05157174542546272,
-0.026619743555784225,
-0.0033702305518090725,
-0.0068046050146222115,
0.012753957882523537,
0.004901667591184378,
-0.021392010152339935,
-0.05700260028243065,
-0.08428516238927841,
0.010471501387655735,
0.0009254102478735149,
0.00023786719248164445,
0.034979838877916336,
-0.020055677741765976,
0.03314104676246643,
0.0017131782369688153,
0.018206194043159485,
-0.03314104676246643,
-0.06050913780927658,
0.043233029544353485,
-0.003124345326796174,
0.006510612089186907,
0.015073830261826515,
0.004760016221553087,
-0.008344059810042381,
-0.012700504623353481,
0.020322944968938828,
-0.029506221413612366,
-0.012016301974654198,
-0.025123050436377525,
-0.004324371926486492,
-0.0005094767548143864,
0.004893649835139513,
-0.04746653139591217,
0.0068847849033772945,
-0.020547447726130486,
-0.01955321803689003,
0.02914273925125599,
0.0034263564739376307,
0.00821042712777853,
-0.009888860397040844,
-0.0230704452842474,
-0.005890553817152977,
0.016132205724716187,
-0.052683573216199875,
-0.007424663286656141,
-0.008108865469694138,
-0.05422302708029747,
0.0173509418964386,
0.003741730935871601,
-0.007879016920924187,
-0.01413305290043354,
0.0317084975540638,
0.03534332290291786,
0.025144431740045547,
-0.01462482288479805,
0.037267640233039856,
0.044729720801115036,
0.010589098557829857,
0.025743110105395317,
0.037075210362672806,
-0.05593353509902954,
0.0155656011775136,
0.00400365237146616,
-0.014742420054972172,
-0.005201006308197975,
-0.028479918837547302,
0.011716963723301888,
0.018420007079839706,
-0.021958615630865097,
0.023604977875947952,
-0.0058264099061489105,
0.04738100618124008,
-0.027432233095169067,
-0.005179625004529953,
-0.051101356744766235,
0.07295306771993637,
-0.033782485872507095,
0.008734269067645073,
-0.024096747860312462,
-0.0136840445920825,
-0.06435777246952057,
0.0050967722199857235,
-0.02587139792740345,
-0.009199312888085842,
0.038764335215091705,
-0.0410735160112381,
0.05217042192816734,
-0.0005749570555053651,
-0.035557135939598083,
-0.013769569806754589,
0.06465711444616318,
-0.00228780135512352,
0.04338269680738449,
0.014892089180648327,
0.015148665755987167,
0.04248468205332756,
0.030382856726646423,
-0.002071315422654152,
0.04648299142718315,
-0.03848637640476227,
-0.022450385615229607,
0.03331209719181061,
-0.023220114409923553,
0.02129579521715641,
-0.00890531949698925,
-0.03790907934308052,
0.034081824123859406,
0.06837746500968933,
0.038251180201768875,
-0.038956765085458755,
0.030618051066994667,
-0.03365419805049896,
-0.016848480328917503,
-0.01051426399499178,
0.014945542439818382,
0.018933158367872238,
0.02168065868318081,
-0.03166573494672775,
0.050374388694763184,
0.02655559964478016,
0.016591904684901237,
0.0330127589404583,
0.019563907757401466,
0.022514529526233673,
-0.022343479096889496,
0.001600926392711699,
-0.011524531990289688,
-0.029206883162260056,
0.03014766052365303,
0.03333347663283348,
-0.03450945019721985,
-0.08501213043928146,
0.03025456890463829,
0.0052544595673680305,
-0.03946991637349129,
0.0012862200383096933,
-0.023861553519964218,
-0.012251496315002441,
0.07718656212091446,
-0.050374388694763184,
0.08573909103870392,
0.055463142693042755,
0.0033729032147675753,
0.001893583219498396,
-0.03053252585232258,
-0.007232231553643942,
-0.04257020726799965,
0.027581902220845222,
-0.059269018471241,
0.04058174416422844,
0.008531146682798862,
0.029078595340251923,
0.0015154010616242886,
0.01849484257400036,
0.007125325035303831,
0.03549299016594887,
-0.014239959418773651,
0.017383012920618057,
-0.030789101496338844,
-0.030382856726646423,
0.046311940997838974,
-0.007916433736681938,
0.02475956827402115,
0.03459497541189194,
-0.021285103633999825,
0.007221540901809931,
-0.049005985260009766,
0.0036000797990709543,
0.0412231869995594,
0.03829394280910492,
0.010182853788137436,
0.02578587271273136,
-0.04862112179398537,
-0.02349807135760784,
0.08017995208501816,
-0.026021067053079605,
-0.027303945273160934,
-0.015105902217328548,
0.05370987579226494,
-0.027368089184165,
0.02287801168859005,
-0.05571972206234932,
0.031109821051359177,
-0.031002914533019066,
-0.03004075400531292,
-0.038251180201768875,
-0.004105213563889265,
0.014539297670125961,
0.029121357947587967,
-0.02249314822256565,
0.012198043055832386,
-0.015864940360188484,
-0.015758033841848373,
-0.0010483528021723032,
-0.004746653139591217,
0.03651929646730423,
0.0012668431736528873,
-0.017361631616950035,
-0.01062117051333189,
0.03942715376615524,
-0.06508474051952362,
0.01089378260076046,
0.02865096926689148,
0.045413922518491745,
-0.038550518453121185,
0.010754804126918316,
-0.03741731122136116,
0.009958350099623203,
0.04188600555062294,
0.006286107935011387,
-0.023348402231931686,
0.0030708920676261187,
-0.02785986103117466,
0.019831174984574318,
-0.012176661752164364,
-0.02764604613184929,
-0.015501457266509533,
-0.020771952345967293,
0.035364702343940735,
0.0074567352421581745,
0.01568319834768772,
0.015758033841848373,
0.03840085119009018,
-0.04058174416422844,
0.003832601709291339,
-0.028415774926543236,
-0.003982271067798138,
0.03771664947271347,
-0.009525378234684467,
-0.03130225092172623,
0.01993808150291443,
0.022835249081254005,
0.036455150693655014,
0.008279915899038315,
-0.005176952108740807,
0.032478224486112595,
-0.006526648066937923,
-0.04105213284492493,
-0.0006895475671626627,
0.000056794131523929536,
0.012069755233824253,
-0.015832867473363876,
-0.008750305511057377,
-0.012657741084694862,
0.03194369375705719,
-0.01089378260076046,
0.009279493242502213,
0.03421011194586754,
0.05892691761255264,
0.04278402030467987,
0.06957481801509857,
-0.013267109170556068,
0.025743110105395317,
-0.024994762614369392,
-0.008825140073895454,
0.021253032609820366,
0.005404128693044186,
-0.023455308750271797,
-0.03324795141816139,
-0.0614926777780056,
-0.019424930214881897,
-0.011032761074602604,
-0.05182832106947899,
-0.026021067053079605,
-0.005134189501404762,
-0.04036793112754822,
-0.00130225601606071,
0.0290572140365839,
-0.02173411101102829,
-0.04079555720090866,
-0.0015675179893150926,
-0.01462482288479805,
-0.03669034689664841,
-0.0013229692121967673,
-0.014346865937113762,
-0.0017171872314065695,
0.030724957585334778,
-0.012198043055832386,
-0.03181540593504906,
-0.047509294003248215,
-0.002915877616032958,
-0.03237131983041763,
-0.020579520612955093,
0.026534218341112137,
-0.029121357947587967,
0.020173275843262672,
-0.005666049662977457,
0.0049230488948524,
0.028586825355887413,
0.0046718185767531395,
-0.019435619935393333,
0.026192117482423782,
-0.011417624540627003,
0.013545066118240356,
-0.035386085510253906,
0.013031914830207825,
-0.009931623004376888,
0.014143743552267551,
-0.006783223710954189,
-0.005275840871036053,
-0.013758879154920578,
-0.0037791484501212835,
-0.01661328598856926,
-0.0206115934997797,
0.0014004764379933476,
-0.008755650371313095,
-0.0352364145219326,
0.011075523681938648,
-0.01402614638209343,
0.0015461366856470704,
-0.024545755237340927,
-0.029420696198940277,
0.050374388694763184,
-0.018430698662996292,
-0.020739881321787834,
0.006922202184796333,
-0.014485844410955906,
0.03793046250939369,
0.00039889526669867337,
-0.01576872356235981,
0.014753110706806183,
-0.024225035682320595,
0.015779415145516396,
-0.036369625478982925,
-0.004212120082229376,
-0.021798256784677505,
0.044815246015787125,
0.0037363856099545956,
0.025443771854043007,
-0.022407623007893562,
-0.030425619333982468,
-0.0151807377114892,
-0.006360942963510752,
0.02287801168859005,
-0.017853401601314545,
0.03423149511218071,
-0.0006264058756642044,
-0.03442392498254776,
0.006200582720339298,
0.012026992626488209,
-0.016923315823078156,
0.01278602983802557,
0.008958772756159306,
-0.0008585936157032847,
0.008493729867041111,
-0.015244881622493267,
-0.030896008014678955,
-0.007472771219909191,
0.0036214611027389765,
-0.0004339739680290222,
0.0017211962258443236,
0.029228264465928078,
0.004273591563105583,
0.056061822921037674,
0.018366554751992226,
-0.02674803137779236,
0.025037525221705437,
0.022514529526233673,
0.010909819044172764,
-0.008659434504806995,
0.006788569036871195,
-0.004118576645851135,
-0.021199578419327736,
-0.02993384748697281,
-0.022664198651909828,
-0.008135592564940453,
0.0023319001775234938,
-0.0017198598943650723,
-0.05323948711156845,
-0.0017345595406368375,
0.002350608818233013,
0.012572215870022774,
-0.014710348099470139,
0.023626359179615974,
-0.04344684258103371,
-0.02358359657227993,
0.03453083336353302,
-0.01139624323695898,
-0.03205059841275215,
0.02745361439883709,
-0.023818790912628174,
0.011962848715484142,
0.021220959722995758,
-0.0389995276927948,
0.014592750929296017,
-0.017832020297646523,
0.0021702039521187544,
0.014603441581130028,
0.005086081568151712,
-0.04618365317583084,
-0.011599366553127766,
0.008360096253454685,
-0.02379740960896015,
-0.015597673133015633,
-0.05341053754091263,
0.006654935888946056,
-0.04028240591287613,
0.004960466176271439,
-0.0014966924209147692,
-0.002231675200164318,
0.005842445883899927,
0.04815073311328888,
0.0577295646071434,
-0.02657698094844818,
0.006056258920580149,
-0.008942737244069576,
-0.007264303509145975,
-0.002510968828573823,
0.010075947269797325,
0.02805229276418686,
0.017500611022114754,
0.01958528906106949,
0.0018508204957470298,
0.05405197665095329,
0.0216485857963562,
0.00597073370590806,
0.00013755873078480363,
-0.00175460462924093,
0.027111513540148735,
0.021220959722995758,
-0.003741730935871601,
-0.018484150990843773,
0.006986346561461687,
-0.012358402833342552,
0.01098999846726656,
-0.015651125460863113,
-0.0475948192179203,
0.018174123018980026,
-0.013470231555402279,
0.02674803137779236,
0.018077906221151352,
0.015790104866027832,
-0.018313100561499596,
0.017682351171970367,
-0.01791754551231861,
-0.054864466190338135,
-0.024545755237340927,
-0.011449696496129036,
0.030190423130989075,
0.01631394773721695,
-0.007494152523577213,
-0.024225035682320595,
-0.02557205967605114,
0.009894206188619137,
0.03617719188332558,
-0.014646204188466072,
-0.012294258922338486,
0.021915853023529053,
-0.008290606550872326,
-0.013951311819255352,
-0.02587139792740345,
0.01615358702838421,
-0.004693199880421162,
-0.012080445885658264,
-0.017244035378098488,
0.008392168208956718,
-0.011674201115965843,
-0.009140514768660069,
-0.011321408674120903,
-0.017575444653630257,
0.03820841759443283,
0.005612596403807402,
0.011791798286139965,
0.005500344559550285,
-0.00535067543387413,
0.01731886900961399,
-0.009087061509490013,
0.043425459414720535,
0.04592707380652428,
-0.045499447733163834,
0.03778079152107239,
-0.019970152527093887,
-0.0067458064295351505,
-0.013491612859070301,
-0.050673726946115494,
-0.036455150693655014,
-0.013010533526539803,
-0.029613127931952477,
0.03713935241103172,
-0.03461635857820511,
-0.023027682676911354,
0.0023519452661275864,
-0.010909819044172764,
0.04387446865439415,
-0.0525125227868557,
-0.009862134233117104,
0.0067939143627882,
-0.0005478963139466941,
0.004789415746927261,
-0.0006344238645397127,
-0.0155656011775136,
0.025208575651049614,
-0.03673310950398445,
-0.0018842287827283144,
0.005489653907716274,
-0.024310560896992683,
-0.020077059045433998,
-0.0006190560525283217,
-0.03455221280455589,
-0.004236174281686544,
-0.03286308795213699,
-0.015693888068199158,
-0.02296353690326214,
-0.03153744712471962,
0.004300318192690611,
0.012689813040196896,
0.004580948036164045,
0.03322657197713852,
0.0048107970505952835,
0.008873247541487217,
0.022322097793221474,
-0.02328425832092762,
0.03192231059074402,
-0.020055677741765976,
-0.02358359657227993,
-0.0013269782066345215,
-0.03284170851111412,
0.0027354727499186993,
0.006521302741020918,
-0.027624664828181267,
0.014239959418773651,
-0.0010543663520365953,
0.017842711880803108,
0.016164278611540794,
-0.005080736242234707,
0.002974676201120019,
0.01069066021591425,
0.018505532294511795,
-0.018730036914348602,
0.00019310004427097738,
0.03034009411931038,
-0.011022070422768593,
-0.011374861933290958,
-0.02685493789613247,
0.029099976643919945,
-0.009894206188619137,
0.020141202956438065,
-0.018334481865167618,
0.035279177129268646,
0.00811421126127243,
-0.058242715895175934,
-0.013919239863753319,
-0.00937036331743002,
-0.009659010916948318,
-0.01726541668176651,
0.014849326573312283,
-0.05802890285849571,
-0.009332946501672268,
0.02745361439883709,
-0.011118286289274693,
0.004260228015482426,
-0.013010533526539803,
0.008980154059827328,
-0.011139667592942715,
0.0012548161903396249,
-0.024845093488693237,
-0.013737497851252556,
-0.07487738132476807,
-0.01615358702838421,
0.046012602746486664,
-0.000020399951608851552,
-0.009824716486036777,
-0.023241495713591576,
0.05430855229496956,
-0.007836253382265568,
0.016581213101744652,
-0.00945054367184639,
-0.021392010152339935,
-0.03222164884209633,
-0.02238624170422554,
-0.02578587271273136,
0.005361366085708141,
-0.02458851784467697,
0.028415774926543236,
-0.018879706040024757,
-0.026021067053079605,
0.014175815507769585,
-0.023049063980579376,
-0.004073141608387232,
-0.005438873078674078,
0.006564065348356962,
0.015244881622493267,
0.017094366252422333,
0.007969886995851994,
-0.03333347663283348,
-0.01548007596284151,
-0.01587563008069992,
0.005190315656363964,
0.01652776077389717,
-0.0075262244790792465,
0.028608206659555435,
-0.05802890285849571,
-0.049305323511362076,
-0.02565758489072323,
-0.00425488268956542,
0.006296798586845398,
0.008066102862358093,
0.03778079152107239,
0.0096536660566926,
0.0303614754229784,
-0.0211888886988163,
0.02606382966041565,
0.020119821652770042,
0.00792712438851595,
-0.03215750679373741,
-0.0033381585963070393,
0.00006347579619614407,
0.016132205724716187,
-0.004265573341399431,
-0.0032446153927594423,
0.012550834566354752,
-0.01002249401062727,
-0.0416080504655838,
0.014710348099470139,
-0.024139510467648506,
-0.02516581304371357,
0.003068219404667616,
-0.0017920219106599689,
-0.0032659966964274645,
0.04806520789861679,
-0.031024295836687088,
-0.03942715376615524,
-0.013128130696713924,
0.008386822417378426,
-0.017575444653630257,
-0.002489587524905801,
-0.008322678506374359,
0.010097328573465347,
0.002632575109601021,
-0.024695424363017082,
0.014485844410955906,
-0.02597830444574356,
0.009236730635166168,
-0.016538450494408607,
-0.015191428363323212,
-0.008643398992717266,
-0.007985923439264297,
0.014688966795802116,
-0.0014779837802052498,
-0.01628187485039234,
0.05246976017951965,
-0.0008973472868092358,
-0.016442235559225082,
-0.015832867473363876,
-0.03510812669992447,
-0.017222654074430466,
0.009840752929449081,
0.029976610094308853,
0.007542260456830263,
-0.02075057104229927,
0.0290572140365839,
-0.02448161132633686,
0.015993228182196617,
-0.025422390550374985,
0.006002805661410093,
-0.00008769681880949065,
0.026919081807136536,
0.01805652491748333,
0.010124054737389088,
-0.0115352226421237,
0.06290384382009506,
0.02260005474090576,
-0.035685423761606216,
-0.012101827189326286,
0.006922202184796333,
0.0008352078148163855,
0.002319873310625553,
-0.010091982781887054,
0.007857635617256165,
0.020665045827627182,
0.0005161584122106433,
-0.032777562737464905,
0.021413391456007957,
-0.00043731482583098114,
-0.02230071648955345,
0.02358359657227993,
0.028822019696235657,
0.05323948711156845,
0.012219424359500408,
0.01297846157103777,
0.005473617929965258,
-0.0196921955794096,
-0.007291030138731003,
0.0038352743722498417,
0.04333993420004845,
0.006441122852265835,
-0.049091510474681854,
0.016623975709080696,
0.015009686350822449,
-0.009525378234684467,
-0.031387776136398315,
0.015191428363323212,
0.05161450803279877,
0.04267711564898491,
-0.005762265995144844,
0.013470231555402279,
0.02895030751824379,
-0.012390474788844585,
-0.026790793985128403,
0.031088439747691154,
-0.051101356744766235,
0.038058750331401825,
-0.0294420775026083,
-0.002950622234493494,
-0.009263456799089909,
0.004049087408930063,
-0.020461922511458397,
-0.007804181892424822,
0.03515088930726051,
0.025850016623735428,
-0.000264760892605409,
-0.03709658980369568,
0.0453711599111557,
0.008707542903721333,
-0.018291719257831573,
0.016495687887072563,
0.023840172216296196,
0.012026992626488209,
0.012828792445361614,
0.015843559056520462,
-0.042142581194639206,
0.004172029905021191,
0.03175126016139984,
0.020825406536459923,
0.04060312733054161,
-0.03512950986623764,
-0.007392591331154108,
-0.034979838877916336,
-0.010674623772501945,
0.0023131915368139744,
-0.008461657911539078,
-0.0196921955794096,
0.0024321251548826694,
0.04207843914628029,
0.0025991667062044144,
-0.020632974803447723,
-0.044430382549762726,
0.004596984013915062,
-0.011171739548444748,
0.0027608629316091537,
-0.034466687589883804,
0.025507915765047073,
0.043724801391363144,
-0.026341786608099937,
-0.012508071959018707,
0.018452079966664314,
0.00045635754941031337,
-0.04485800862312317,
-0.0037123316433280706,
0.05302567407488823,
-0.008654089644551277,
0.06217687949538231,
-0.0406886525452137,
0.032093361020088196,
0.005751575343310833,
0.022642817348241806,
-0.00549499923363328,
-0.0137802604585886,
-0.01647430658340454,
0.020793333649635315,
-0.041543904691934586,
-0.03282032534480095,
-0.013940621167421341,
-0.023647740483283997,
-0.02277110517024994,
-0.0008966791210696101,
0.056361161172389984,
0.04098799079656601,
-0.014742420054972172,
0.009525378234684467,
-0.02227933518588543,
0.051101356744766235,
0.01367335394024849,
0.02377602830529213,
0.012518762610852718,
-0.003343503922224045,
-0.01914697140455246,
-0.025336863473057747,
0.02706875093281269,
-0.018184812739491463,
0.0509730689227581,
0.022856630384922028,
-0.003915454261004925,
-0.051700033247470856,
-0.014763801358640194,
0.008664780296385288,
0.04340407997369766,
-0.012101827189326286,
-0.024139510467648506,
-0.00701841851696372,
-0.008867902681231499,
-0.0020739880856126547,
0.04425933212041855,
0.005628632381558418,
0.03232855722308159,
0.014699657447636127,
0.015052448958158493,
0.0045943111181259155,
0.014058218337595463,
0.010904473252594471,
0.008916010148823261,
0.0022931466810405254,
-0.011588675901293755,
-0.03155883029103279,
0.02933517098426819,
0.004797433502972126,
0.006628209259361029,
-0.020568830892443657,
0.04115904122591019,
0.02113543450832367,
0.001975099556148052,
0.0296345092356205,
-0.013267109170556068,
0.0048802862875163555,
0.002660637954249978,
-0.017147818580269814,
-0.007991268299520016,
0.012957080267369747,
0.005388092715293169,
0.005906589794903994,
-0.00016286553000099957,
-0.021723421290516853,
-0.008541837334632874,
-0.013096058741211891,
0.02446023002266884,
-0.0016864516073837876,
-0.00917793158441782,
-0.022514529526233673,
0.0034504104405641556,
-0.022942155599594116,
-0.04090246558189392,
0.01119312085211277,
-0.006777878385037184,
0.014015455730259418,
-0.014453772455453873,
-0.04887769743800163,
-0.012026992626488209,
0.020419159904122353,
-0.006825986318290234,
-0.011674201115965843,
0.006045568268746138,
0.029784178361296654,
-0.021659277379512787,
0.007916433736681938,
0.018473461270332336,
-0.003698968328535557,
-0.03474464640021324,
-0.02143477275967598,
0.06794983893632889,
-0.018997302278876305,
-0.07551882416009903,
0.007975232787430286,
0.037460073828697205,
-0.010161472484469414,
0.014902779832482338,
0.0013937947805970907,
0.001419185078702867,
0.007355174049735069,
0.021306484937667847,
0.00631817989051342,
0.01582217775285244,
0.016271185129880905,
0.0041586668230593204,
-0.010444775223731995,
-0.030104897916316986,
-0.02268557995557785,
0.007045145146548748,
-0.010124054737389088,
-0.014047527685761452,
-0.016656048595905304,
0.016303256154060364,
-0.012518762610852718,
0.023327020928263664,
0.005227732937783003,
0.029399314895272255,
0.0011058151721954346,
0.0034263564739376307,
0.00006631550058955327,
-0.00850976537913084,
0.007889707572758198,
-0.029484840109944344,
0.00005311921631800942,
0.018452079966664314,
0.01601460948586464,
0.008050067350268364,
-0.01308536808937788,
0.0007296375697478652,
0.005315930582582951,
-0.005527071189135313,
-0.0369255393743515,
0.04490077123045921,
-0.026234880089759827,
-0.043510984629392624,
0.04609812796115875,
0.0036214611027389765,
0.0003938839945476502,
0.014806563965976238,
0.00649457611143589,
-0.0068152956664562225,
-0.006195237394422293,
-0.014293412677943707,
0.011973539367318153,
0.021819638088345528,
-0.027325326576828957,
-0.0003175460151396692,
-0.010909819044172764,
-0.015212809666991234,
-0.0014953560894355178,
-0.025700347498059273,
0.006863403599709272,
0.014346865937113762,
0.03483017161488533,
-0.0348515510559082,
-0.004471368622034788,
0.015319716185331345,
-0.0012013629311695695,
0.04507182165980339,
0.02993384748697281,
-0.009969040751457214,
0.04002583026885986,
0.0015715269837528467,
-0.013512994162738323,
-0.024845093488693237,
0.009103097021579742,
0.025935541838407516,
-0.011909395456314087,
-0.042762640863657,
-0.013309871777892113,
0.01870865561068058,
0.01900799386203289,
0.00878237746655941,
-0.016431543976068497,
0.027795715257525444,
-0.008477693423628807,
-0.01701953075826168,
0.008349405601620674,
-0.022706961259245872,
-0.0009046971099451184,
-0.019029375165700912,
0.02034432627260685,
-0.021755492314696312,
-0.026705268770456314,
0.007435353938490152,
-0.003078910056501627,
0.01502037700265646,
0.017725113779306412,
0.0021220960188657045,
0.040731415152549744,
-0.0012127218069508672,
-0.0036936230026185513,
-0.009119133464992046,
-0.0008639389416202903,
-0.04588431119918823,
0.015405241400003433,
-0.03572818636894226,
0.01164212916046381,
0.010327178053557873,
-0.01298915222287178,
-0.02895030751824379,
-0.020355015993118286,
-0.001949709141626954,
-0.01014543604105711,
0.0061631654389202595,
0.007601059507578611,
-0.0028650967869907618,
0.028822019696235657,
-0.0005762933869846165,
0.001586226630024612,
-0.018120668828487396,
0.012925008311867714,
0.006697698496282101,
-0.0018989285454154015,
0.010385976172983646,
-0.008990844711661339,
-0.01148176845163107,
-0.0018334481865167618,
-0.00004931902003590949,
0.0011519186664372683,
-0.02366912178695202,
0.016249803826212883,
-0.021392010152339935,
0.004605001769959927,
0.04716719314455986,
0.00012227441766299307,
0.01759682595729828,
-0.028223343193531036,
-0.0036802596878260374,
-0.0018334481865167618,
0.0009200649219565094,
0.03489431366324425,
0.022429004311561584,
0.04438761994242668,
-0.03483017161488533,
-0.010268379002809525,
-0.0013617228250950575,
0.008311987854540348,
-0.03673310950398445,
-0.0013924584491178393,
0.029613127931952477,
0.025229956954717636,
-0.028223343193531036,
-0.021263722330331802,
0.012272877618670464,
-0.006441122852265835,
0.005842445883899927,
0.014218578115105629,
-0.017244035378098488,
-0.012967770919203758,
-0.03634824603796005,
-0.019382167607545853,
0.006195237394422293,
0.0003588052641134709,
0.011064833030104637,
-0.0010309804929420352,
0.010653242468833923,
-0.03718211501836777,
0.050887543708086014,
0.02666250616312027,
0.006809950340539217,
-0.019724268466234207,
-0.02085747756063938,
0.024716805666685104,
-0.014934851787984371,
0.0016209713649004698,
0.01661328598856926,
0.0010683978907763958,
-0.016388781368732452,
-0.02023741975426674,
0.04964742437005043,
0.01069066021591425,
0.002259738277643919,
0.005687430966645479,
-0.01955321803689003,
-0.01148176845163107,
0.0033328132703900337,
0.0032633240334689617,
0.01906144618988037,
-0.023904316127300262,
0.01492416113615036,
-0.002388026099652052,
0.008648743852972984,
0.01194146741181612,
0.029869703575968742,
-0.0011906722793355584,
-0.015490766614675522,
-0.0008398849749937654,
-0.04147976264357567,
-0.09647251665592194,
0.007483461871743202,
0.01886901445686817,
-0.02197999693453312,
-0.0028650967869907618,
-0.03153744712471962,
0.013545066118240356,
0.040453456342220306,
-0.018644511699676514,
0.014443081803619862,
0.053282249718904495,
0.03998306766152382,
0.01976703107357025,
0.026234880089759827,
0.012818101793527603,
0.015993228182196617,
-0.018772799521684647,
0.016923315823078156,
-0.012572215870022774,
-0.020686427131295204,
0.02875787578523159,
-0.012112517841160297,
0.034979838877916336,
0.02091093175113201,
-0.002918550278991461,
0.003984943497925997,
-0.013395396992564201,
-0.030019372701644897,
0.027410851791501045,
-0.02696184441447258,
-0.007130670361220837,
-0.010642551816999912,
0.012048373930156231,
-0.02219380997121334,
0.01936078630387783,
0.032991375774145126,
-0.000546894094441086,
0.00654268404468894,
0.020333634689450264,
0.039640966802835464,
-0.028928926214575768,
-0.0059653883799910545,
0.03363281488418579,
0.03589923679828644,
-0.009226039983332157,
-0.013737497851252556,
-0.024952000007033348,
-0.01357713807374239,
0.00701841851696372,
0.02134924754500389,
-0.0017185235628858209,
-0.022813867777585983,
0.019179044291377068,
-0.01297846157103777,
-0.015159356407821178,
0.009183277375996113,
0.01971357688307762,
0.008536492474377155,
-0.002172876615077257,
0.011449696496129036,
-0.014582060277462006,
-0.03968372941017151,
-0.00011099912080680951,
-0.02456713654100895,
-0.010439429432153702,
-0.02557205967605114,
0.009300874546170235,
-0.013042605482041836,
0.009033607318997383,
-0.018174123018980026,
0.01993808150291443,
-0.019724268466234207,
-0.018836943432688713,
0.010450120083987713,
0.0029132049530744553,
0.007788145914673805,
0.018612438812851906,
-0.03711797297000885,
-0.01960667036473751,
-0.003124345326796174,
-0.010728077031672001,
-0.011171739548444748,
-0.008857212029397488,
-0.05191384628415108,
0.007606404833495617,
0.024438848719000816,
-0.013427468948066235,
0.020002225413918495,
0.026726650074124336,
-0.004768034443259239,
0.017308179289102554,
-0.03136639669537544,
0.004797433502972126,
0.013726807199418545,
0.03688277676701546,
-0.0075262244790792465,
-0.012572215870022774,
0.0026031758170574903,
-0.014485844410955906,
0.006168510764837265,
-0.01920042559504509,
-0.03320518881082535,
-0.010380631312727928,
-0.04562773555517197,
0.02805229276418686,
0.006013496313244104,
0.0153731694445014,
-0.015116593800485134,
0.015501457266509533,
-0.04336131736636162,
0.009300874546170235,
0.0032312520779669285,
-0.010749458335340023,
0.015383860096335411,
0.0414583794772625,
-0.01403683703392744,
0.018804870545864105,
0.005708812270313501,
0.016431543976068497,
-0.013801641762256622,
0.011011379770934582,
0.010450120083987713,
-0.014443081803619862,
-0.014571369625627995,
0.025294100865721703,
0.03880709782242775,
-0.02548653446137905,
-0.007349828723818064,
-0.010947235859930515,
-0.0074460445903241634,
0.007697275374084711,
-0.0551210418343544,
0.00684202229604125,
0.003343503922224045,
0.006895475555211306,
-0.0028570787981152534,
0.012625669129192829,
-0.058755867183208466,
-0.003364885225892067,
-0.01032183226197958,
-0.016442235559225082,
-0.001312946667894721,
0.0017559409607201815,
-0.012369093485176563,
0.008760996162891388,
-0.013844404369592667,
0.017842711880803108,
0.019050756469368935,
0.020515376701951027,
-0.0066763171926140785,
0.011118286289274693,
-0.030318712815642357,
-0.016239112243056297,
0.025144431740045547,
-0.008825140073895454,
0.004645091947168112,
0.005724848248064518,
0.0031323633156716824,
-0.0015822176355868578,
0.027731571346521378,
0.020173275843262672,
-0.012091136537492275,
-0.011770416982471943,
-0.011150358244776726,
0.04169357568025589,
-0.020226728171110153,
0.0038406196981668472,
0.10836052894592285,
-0.024032603949308395,
0.004915031138807535,
-0.0045943111181259155,
0.0009053652756847441,
-0.005270495545119047,
0.031109821051359177,
0.004944430198520422,
0.03085324540734291,
-0.00435109855607152,
0.02358359657227993,
0.03525779768824577,
0.028308868408203125,
0.003984943497925997,
0.052897386252880096,
-0.01920042559504509,
-0.007002382539212704,
0.02505890652537346,
-0.0029800215270370245,
-0.008039376698434353,
0.015116593800485134,
0.018911777064204216,
-0.008295952342450619,
0.0288647823035717,
-0.02895030751824379,
0.024823712185025215,
-0.015619054436683655,
-0.017489919438958168,
0.0015955810667946935,
0.025401009246706963,
0.012721885927021503,
0.02140270173549652,
0.02418227307498455,
-0.008862556889653206,
-0.011182430200278759,
-0.03083186410367489,
-0.01224080566316843,
0.0008913337951526046,
-0.0035867164842784405,
0.012572215870022774,
0.005136861931532621,
-0.02029087208211422,
-0.020846787840127945,
0.0038700189907103777,
0.01865520142018795,
0.0009962358744814992,
-0.022728342562913895,
0.0027635355945676565,
0.02197999693453312,
-0.020793333649635315,
-0.007766764611005783,
0.007713311351835728,
0.011449696496129036,
-0.031879547983407974,
-0.040945228189229965,
-0.0348515510559082,
-0.00879841297864914,
-0.010289760306477547,
0.00622196402400732,
-0.007547605782747269,
-0.0067458064295351505,
0.021498916670680046,
0.03166573494672775,
-0.017286797985434532,
-0.011620747856795788
] | 2024-07-11 | 74 | 38987565 | [
"NK cells",
"tumor cells",
"adoptive cell transfers",
"anti-tumor immune responses",
"tumor immunotherapy",
"anti-tumor effects",
"CAR-NK cell therapies",
"CAR-NK cell therapy",
"CAR-T cell therapies",
"tumor immunosurveillance",
"CAR-NK cells",
"CAR-T cells",
"Active immunotherapy",
"tumor",
"Cancer immunotherapy",
"cancer immunotherapy",
"immune evasion mechanisms",
"CAR-T cell modalities",
"T",
"immunotherapy",
"cytokine release syndrome",
"host immunity",
"oncological treatment",
"anti-PD-L1",
"significant traction",
"monoclonal antibodies",
"future potential",
"exogenous agents",
"combat malignancies",
"CAR"
] | [] | 0 | 10.1038/s41420-024-02077-1
10.1038/s41586-023-05707-3
10.1038/s41571-021-00530-z
10.1126/sciadv.aaz3223
10.1021/acssynbio.1c00256
10.1038/s41586-023-06243-w
10.3389/fimmu.2023.1188049
10.1186/s13045-017-0423-1
10.1038/s41571-023-00729-2
10.1186/s12943-022-01663-0
10.2478/jtim-2023-0097
10.1038/s41591-022-01969-y
10.1038/s41591-022-01959-0
10.3324/haematol.2022.280805
10.3389/fimmu.2023.1166038
10.1186/s13046-022-02327-z
10.1016/j.ebiom.2020.102975
10.1016/s1471-4906(01)02060-9
10.1186/s13045-021-01083-5
10.3389/fimmu.2021.707542
10.3389/fimmu.2019.03038
10.1038/s41392-022-01058-z
10.1186/s13045-022-01382-5
10.1038/s41587-019-0329-2
10.1056/NEJMoa1910607
10.1093/neuonc/noad087
10.1016/j.blre.2018.11.002
10.1182/blood.2022017414
10.1016/j.annonc.2020.10.478
10.1186/s13046-021-02148-6
10.1016/j.jaci.2020.07.025
10.1186/s40364-022-00364-6
10.1158/0008-5472.Can-21-0035
10.1186/s13045-022-01376-3
10.1038/s41467-022-30216-8
10.1053/j.gastro.2021.12.281
10.1186/s12943-023-01723-z
10.1016/j.stem.2020.05.008
10.1016/j.stem.2018.06.002
10.3892/ol.2023.13822
10.1038/s41467-020-18444-2
10.3389/fonc.2019.01448
10.1371/journal.pone.0030264
10.1016/j.bbrc.2020.12.012
10.1016/j.reth.2022.07.001
10.1186/s12935-021-01983-z
10.3389/fonc.2022.834002
10.1016/j.jcyt.2022.07.008
10.1016/j.omto.2022.10.011
10.1016/j.jcyt.2022.10.002
10.1038/s41419-024-06438-7
10.1111/cas.14374
10.1016/j.bioactmat.2023.03.018
10.1186/s12935-023-03153-9
10.1016/j.jcyt.2021.08.003
10.1016/j.jcyt.2022.02.005
10.1007/s13238-019-00665-x
10.1007/s00262-021-02975-8
10.1016/j.jcyt.2021.05.001
10.1038/s41586-022-05254-3
10.1136/jitc-2021-003416
10.3389/fimmu.2023.1303605
10.1158/1078-0432.Ccr-22-3379
10.1016/j.jcyt.2022.04.001
10.1136/jitc-2020-001502
10.1016/j.phrs.2022.106132
10.1016/j.omtm.2022.10.010
10.1016/j.tips.2023.08.009
10.1038/s41467-023-43079-4
10.1016/j.cell.2018.10.014
10.1016/j.jconrel.2020.07.016 | [
"Zhong",
"Liu"
] | [
"Department of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.",
"Shenzhen Key Laboratory of Immunity and Inflammatory Diseases, Peking University Shenzhen Hospital, Shenzhen, China. [email protected].\nInstitute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, China. [email protected]."
] | [
"38987565",
"36813894",
"34230645",
"32637585",
"35005887",
"37495877",
"37256141",
"28222796",
"36721024",
"36209106",
"37662884",
"36138152",
"36097221",
"35770532",
"37205115",
"35361234",
"32853984",
"11698225",
"33933160",
"34970253",
"32038612",
"35768424",
"36348457",
"31907405",
"32023374",
"37148198",
"30528964",
"36989488",
"33098993",
"34794490",
"32771558",
"37029381",
"35303962",
"34006525",
"36335396",
"35546150",
"34999097",
"36717905",
"32531207",
"30082067",
"37153038",
"32968061",
"31921693",
"22279576",
"33309274",
"35919498",
"34098947",
"35449580",
"36050244",
"36420307",
"36280438",
"38221520",
"32133731",
"37091063",
"38012684",
"34656419",
"35461759",
"31691903",
"34983953",
"34218295",
"34272175",
"36198789",
"35338085",
"38022646",
"36595561",
"35589475",
"33737337",
"35183714",
"38331849",
"36381305",
"37770314",
"37945606",
"30503213",
"32682905"
] | [] | 11.26593 | 5.414568 |
38987430 | 738 | CD87-targeted BiTE and CAR-T cells potently inhibit invasive nonfunctional pituitary adenomas. | Recently, bispecific T-cell engagers (BiTEs) and chimeric antigen receptor-modified T cells (CAR-Ts) have been shown to have high therapeutic efficacy in hematological tumors. CD87 is highly expressed in solid tumors with an oncogenic function. To assess their cytotoxic effects on invasive nonfunctioning pituitary adenomas (iNFPAs), we first examined CD87 expression and its effects on the metabolism of iNFPA cells. We generated CD87-specific BiTE and CAR/IL-12 T cells, and their cytotoxic effects on iNFPAs cells and in mouse models were determined. CD87 had high expression in iNFPA tissue and cell samples but was undetected in noncancerous brain samples. CD87×CD3 BiTE and CD87 CAR/IL-12 T-cells showed antigenic specificity and exerted satisfactory cytotoxic effects, decreasing tumor cell proliferation in vitro and reducing existing tumors in experimental mice. Overall, the above findings suggest that CD87 is a promising target for the immunotherapeutic management of iNFPAs using anti-CD87 BiTE and CD87-specific CAR/IL-12 T cells. | [
-0.00463508116081357,
-0.0025253419298678637,
0.041293781250715256,
0.031877681612968445,
-0.02162403240799904,
-0.053349435329437256,
0.007430088706314564,
0.012582293711602688,
0.00765216676518321,
-0.03388272970914841,
0.05324791371822357,
-0.00022207781148608774,
-0.03543092682957649,
0.003930777311325073,
0.02385750226676464,
-0.01239828672260046,
0.0039053969085216522,
-0.01442871242761612,
0.009784113615751266,
0.028222916647791862,
0.022055499255657196,
0.031395457684993744,
-0.006878066807985306,
0.00044812128180637956,
0.03890803083777428,
-0.03175077959895134,
0.018413422629237175,
0.013997246511280537,
0.017664702609181404,
-0.009244781918823719,
0.028730522841215134,
-0.012582293711602688,
-0.04360339045524597,
-0.00937168300151825,
-0.0007665649754926562,
0.02672547847032547,
0.03157312050461769,
-0.0015355093637481332,
-0.012093722820281982,
-0.031192414462566376,
0.02189052663743496,
0.02187783643603325,
-0.015050530433654785,
0.047791142016649246,
-0.04499930888414383,
-0.035481687635183334,
-0.0001856927410699427,
-0.03530402481555939,
0.002149395877495408,
0.006675024516880512,
0.010666079819202423,
0.05624279007315636,
0.0012912238016724586,
0.0432734452188015,
-0.030735569074749947,
0.06121733412146568,
-0.010685115121304989,
0.027309225872159004,
0.005758160259574652,
-0.007043038960546255,
0.01732206903398037,
-0.024593530222773552,
0.03365430608391762,
-0.003066259901970625,
-0.05223270133137703,
-0.027004661038517952,
-0.08355201780796051,
-0.03999938443303108,
0.024415869265794754,
-0.010666079819202423,
0.02239813283085823,
-0.02845134027302265,
-0.025316869840025902,
-0.004819088149815798,
0.052588023245334625,
-0.030634047463536263,
0.001857522176578641,
0.030659427866339684,
-0.02068496122956276,
-0.009378028102219105,
0.01567234843969345,
0.023781361058354378,
0.0008780004573054612,
-0.03256295248866081,
-0.008756211027503014,
0.018921028822660446,
0.026522435247898102,
-0.05492301285266876,
-0.06274015456438065,
-0.012125448323786259,
0.023794051259756088,
0.02361638844013214,
-0.04459322243928909,
0.03340050205588341,
-0.013261217623949051,
-0.025862546637654305,
0.014695205725729465,
-0.05893310531973839,
0.009073464199900627,
0.03609081730246544,
0.02644629403948784,
0.016941364854574203,
0.0027061766013503075,
0.013413499109447002,
0.04956776648759842,
0.011008714325726032,
-0.03538016602396965,
0.002630035625770688,
0.016230715438723564,
0.0067130946554243565,
0.10842473059892654,
0.013261217623949051,
-0.019809341058135033,
0.042512036859989166,
-0.03517712280154228,
-0.04286736249923706,
-0.009593761526048183,
0.01225234940648079,
-0.016751011833548546,
0.036471519619226456,
-0.007468159310519695,
0.04307040572166443,
0.009067119099199772,
-0.042968884110450745,
0.004711221903562546,
-0.07177554816007614,
0.07756225764751434,
-0.019212903454899788,
-0.008864076808094978,
-0.05603974685072899,
0.009568381123244762,
-0.025621432811021805,
0.0371314100921154,
-0.02145906165242195,
-0.08477026969194412,
0.006062724161893129,
-0.000018911312508862466,
0.0018162791384384036,
-0.019441325217485428,
0.00006062525790184736,
0.01587538979947567,
0.008565858006477356,
0.006116657052189112,
-0.03728369250893593,
-0.061521898955106735,
-0.03677608445286751,
-0.017943887040019035,
-0.014758656732738018,
0.04403485730290413,
0.021382920444011688,
-0.005028476007282734,
0.06878066807985306,
0.028552860021591187,
-0.06548123061656952,
-0.0582224540412426,
-0.019149452447891235,
0.0007784620393067598,
0.0569026805460453,
0.017880436033010483,
-0.038451187312603,
-0.013997246511280537,
0.01807078905403614,
-0.00204311590641737,
-0.0070366938598454,
0.03370506688952446,
0.048780977725982666,
-0.002807697979733348,
0.009054429829120636,
-0.0432734452188015,
0.05218194052577019,
-0.0014522302662953734,
-0.014416022226214409,
-0.08690221607685089,
-0.0012047720374539495,
-0.054770730435848236,
0.002204915275797248,
0.024682361632585526,
0.012563258409500122,
-0.014416022226214409,
0.005523392464965582,
-0.004771500360220671,
0.042765840888023376,
0.011947785504162312,
0.023908261209726334,
-0.020329637452960014,
0.02933965064585209,
-0.00270300405099988,
0.02501230686903,
-0.015367784537374973,
-0.007062074262648821,
0.03639537841081619,
0.0024016129318624735,
0.0669025257229805,
0.0662933960556984,
-0.013781514018774033,
-0.025875236839056015,
0.023768670856952667,
0.00572008965536952,
-0.053755518049001694,
-0.006649644114077091,
0.026370152831077576,
-0.03535478562116623,
-0.031649257987737656,
0.03824814409017563,
-0.03705526888370514,
-0.010805671103298664,
0.007487194612622261,
0.0365222804248333,
0.015748489648103714,
-0.002833078382536769,
0.06213102489709854,
-0.016230715438723564,
0.007201666012406349,
-0.02263924665749073,
0.020799173042178154,
-0.02913660742342472,
0.0038419461343437433,
0.04906015843153,
0.03829890489578247,
0.02145906165242195,
-0.014669825322926044,
-0.02933965064585209,
-0.012772646732628345,
0.031217794865369797,
-0.0054504238069057465,
0.01583731919527054,
-0.007715617306530476,
-0.0197712704539299,
-0.025101136416196823,
-0.00499357795342803,
-0.011345003731548786,
-0.037664394825696945,
0.04398409649729729,
-0.002896529156714678,
-0.041268400847911835,
0.012322145514190197,
-0.020583439618349075,
-0.00517124030739069,
0.02285497821867466,
-0.021065665408968925,
0.007531610317528248,
0.02624325081706047,
0.0072587719187140465,
-0.02939041145145893,
-0.018349971622228622,
-0.005298141855746508,
0.01875605620443821,
-0.0466490276157856,
-0.007417398504912853,
-0.0006939931190572679,
-0.0345933772623539,
-0.013451569713652134,
-0.014606374315917492,
-0.010018881410360336,
-0.02433972805738449,
0.005618568509817123,
0.04324806481599808,
-0.005161722656339407,
0.007620441261678934,
-0.0026760376058518887,
0.02313416264951229,
0.05746104568243027,
-0.0010279029374942183,
-0.042715080082416534,
-0.09944009780883789,
-0.02791835181415081,
0.00782982911914587,
0.010831051506102085,
-0.021535202860832214,
-0.02675085887312889,
0.034060388803482056,
0.017398210242390633,
0.048755597323179245,
-0.01526626292616129,
-0.0370045080780983,
0.0572580024600029,
-0.027106182649731636,
0.009841219522058964,
-0.003772150259464979,
0.000031675830541644245,
-0.0366491824388504,
0.0199489314109087,
0.021357540041208267,
-0.03172539919614792,
-0.023400655016303062,
-0.023476796224713326,
0.010748566128313541,
-0.016040362417697906,
-0.03918721526861191,
-0.03147159889340401,
0.0033184769563376904,
0.003940294962376356,
-0.01583731919527054,
-0.03373044729232788,
-0.023400655016303062,
-0.00033291842555627227,
0.013578471727669239,
-0.0424358956515789,
-0.00540600810199976,
0.012531532905995846,
-0.032359909266233444,
-0.025596054270863533,
-0.01529164332896471,
-0.0103678610175848,
-0.019086001440882683,
0.03243605047464371,
0.004666806664317846,
0.012442702427506447,
0.022753456607460976,
0.007265116553753614,
0.02190321683883667,
0.03208072483539581,
0.02114180661737919,
0.02284228801727295,
-0.008806970901787281,
-0.0010858018649742007,
0.025316869840025902,
-0.03195382282137871,
0.023679839447140694,
-0.004952335264533758,
-0.03131931647658348,
-0.021268708631396294,
-0.03702988848090172,
0.011116580106317997,
-0.013400808908045292,
-0.007550645619630814,
0.014377951622009277,
0.047562722116708755,
0.028730522841215134,
-0.014682515524327755,
0.046826690435409546,
0.04071003571152687,
-0.014149528928101063,
0.017220547422766685,
-0.015075910836458206,
-0.009320923127233982,
-0.048476412892341614,
-0.021027594804763794,
-0.006510052364319563,
0.03416191041469574,
0.005034821107983589,
0.06969436258077621,
-0.05253726243972778,
0.05609050765633583,
-0.023058021441102028,
-0.0018987652147188783,
-0.016776392236351967,
0.03606543689966202,
0.009479549713432789,
0.007671202067285776,
0.00791865959763527,
0.010025226511061192,
0.03276599571108818,
0.018908338621258736,
0.009955430403351784,
-0.01406069751828909,
-0.011224446818232536,
-0.03804510086774826,
0.006414875853806734,
0.029288889840245247,
0.009707972407341003,
-0.030684808269143105,
-0.017639322206377983,
0.07578563690185547,
0.01612919382750988,
0.031852301210165024,
-0.01167494710534811,
-0.002444442128762603,
-0.039847102016210556,
-0.0327913761138916,
-0.010012536309659481,
0.0039371224120259285,
-0.007677547167986631,
0.009600106626749039,
-0.02865438163280487,
0.027842212468385696,
0.010507452301681042,
0.021294089034199715,
0.02672547847032547,
0.02746150642633438,
0.04601452127099037,
0.00392125966027379,
-0.00817246362566948,
-0.04235975444316864,
-0.03543092682957649,
0.026801617816090584,
0.04931396245956421,
-0.0327913761138916,
-0.04527849331498146,
0.050405316054821014,
0.06263863295316696,
-0.03725831210613251,
0.05070988088846207,
-0.01567234843969345,
-0.04093845561146736,
0.039821721613407135,
-0.030963990837335587,
0.05058297887444496,
0.02982187643647194,
0.008413576520979404,
-0.04162372648715973,
-0.01683984324336052,
-0.011027749627828598,
-0.03974558040499687,
0.014048007316887379,
0.0015846837777644396,
0.04697897285223007,
0.00805190671235323,
0.019834721460938454,
-0.01610381342470646,
-0.02695390023291111,
-0.011116580106317997,
0.021725554019212723,
0.015507375821471214,
0.025913307443261147,
-0.005168067757040262,
-0.028222916647791862,
0.046319086104631424,
-0.03322283923625946,
0.027486886829137802,
0.012436357326805592,
-0.04256279766559601,
0.016408376395702362,
-0.028096014633774757,
-0.024441249668598175,
-0.02337527461349964,
0.03350202366709709,
-0.006808271165937185,
0.02768993005156517,
-0.04746120050549507,
0.004260721150785685,
0.07669933140277863,
-0.007855209521949291,
-0.003209024202078581,
-0.02483464404940605,
-0.011751088313758373,
-0.0038958792574703693,
0.03484718129038811,
-0.06685176491737366,
0.06431373208761215,
-0.0448470264673233,
0.009111534804105759,
-0.021750934422016144,
-0.030024919658899307,
0.009911015629768372,
0.013108935207128525,
0.01610381342470646,
0.0015846837777644396,
-0.03469489887356758,
-0.010380551218986511,
-0.0015140947652980685,
-0.016535278409719467,
0.004543077200651169,
0.030735569074749947,
-0.014999769628047943,
-0.009225746616721153,
0.022195089608430862,
-0.03053252585232258,
-0.02865438163280487,
-0.0032439222559332848,
0.07583639770746231,
-0.06228330731391907,
0.009422443807125092,
-0.029212748631834984,
-0.022715387865900993,
0.039847102016210556,
0.029694974422454834,
-0.0033438573591411114,
0.03137007728219032,
-0.050151512026786804,
-0.0295934546738863,
-0.019822031259536743,
0.022753456607460976,
0.015342404134571552,
-0.030456384643912315,
0.024238206446170807,
0.015317023731768131,
-0.008394541218876839,
-0.009327268227934837,
-0.008838696405291557,
0.007702927105128765,
-0.015697728842496872,
-0.028578240424394608,
0.011484595015645027,
0.07309532165527344,
0.029644213616847992,
0.02837519906461239,
-0.005688364151865244,
-0.009631832130253315,
0.04380643367767334,
-0.029923398047685623,
-0.011110235005617142,
0.05314639210700989,
-0.01373075321316719,
-0.029720354825258255,
-0.04228361323475838,
0.015088601037859917,
-0.023641768842935562,
-0.0018749712035059929,
0.015215502120554447,
0.03388272970914841,
0.01876874640583992,
0.008261294104158878,
-0.006281629204750061,
0.044390179216861725,
0.042994264513254166,
-0.004476454108953476,
0.056699637323617935,
-0.018451493233442307,
-0.007937694899737835,
0.007963075302541256,
0.013781514018774033,
0.022791527211666107,
-0.040100906044244766,
-0.021484442055225372,
-0.01827383041381836,
-0.013578471727669239,
-0.002549136057496071,
-0.016738321632146835,
-0.002975842682644725,
-0.012455392628908157,
0.004330517258495092,
-0.0007249254267662764,
0.0063292174600064754,
0.02427627705037594,
-0.045380014926195145,
-0.0332736000418663,
-0.06548123061656952,
-0.009536655619740486,
-0.05964375287294388,
0.016674870625138283,
-0.017753534018993378,
0.02961883507668972,
0.0030868814792484045,
-0.0332736000418663,
0.009333613328635693,
0.0015236124163493514,
0.03464413806796074,
-0.029238129034638405,
0.0007947213016450405,
0.014707895927131176,
-0.008381851017475128,
0.0015585103537887335,
-0.019910860806703568,
0.029568074271082878,
0.006586193107068539,
0.025393011048436165,
-0.023146852850914,
0.004533559549599886,
0.008204188197851181,
-0.001537095638923347,
-0.019580917432904243,
0.011211756616830826,
0.02768993005156517,
0.025887927040457726,
-0.000361867860192433,
0.007779068313539028,
-0.0520804189145565,
0.01803271844983101,
0.008927527815103531,
-0.002877493854612112,
-0.013032794930040836,
-0.016738321632146835,
-0.034517236053943634,
0.011046784929931164,
0.016230715438723564,
0.01590077020227909,
-0.010056952014565468,
-0.045126210898160934,
0.043933335691690445,
-0.04939010366797447,
0.035481687635183334,
-0.023273754864931107,
-0.0006586986128240824,
0.027156943455338478,
0.0062467316165566444,
-0.05482149124145508,
0.007303187157958746,
-0.01687791384756565,
0.024860024452209473,
-0.01590077020227909,
-0.0013903656508773565,
-0.011306933127343655,
0.03395886719226837,
0.0037245620042085648,
0.01781698502600193,
-0.01972050964832306,
0.020799173042178154,
0.007658511865884066,
-0.02093876525759697,
-0.0020113904029130936,
-0.03180154040455818,
0.011554391123354435,
-0.0026776238810271025,
-0.020380398258566856,
0.001962216105312109,
0.01687791384756565,
-0.01710633561015129,
-0.02384481206536293,
0.030557906255126,
0.006373633164912462,
-0.03395886719226837,
0.007150905206799507,
-0.025228038430213928,
-0.0011151478393003345,
0.016776392236351967,
0.0022350545041263103,
0.0033565473277121782,
-0.007779068313539028,
0.009238436818122864,
0.053095631301403046,
0.0437556728720665,
-0.007595060858875513,
-0.004089404363185167,
-0.004441556055098772,
-0.0016322719166055322,
-0.016560658812522888,
-0.006364115513861179,
0.01276630163192749,
-0.034263432025909424,
-0.037892818450927734,
0.012690160423517227,
-0.02216970920562744,
-0.005101444665342569,
-0.014771346934139729,
0.0008240672759711742,
-0.018870268017053604,
-0.005555117502808571,
-0.031243175268173218,
-0.001084215589798987,
0.009073464199900627,
-0.019136762246489525,
-0.019618988037109375,
0.023197613656520844,
0.010418621823191643,
-0.04494854807853699,
0.021370230242609978,
-0.021547893062233925,
-0.010919882915914059,
-0.011966820806264877,
-0.0100950226187706,
0.013921106234192848,
0.0057169171050190926,
-0.009333613328635693,
0.02096414566040039,
-0.0007622027769684792,
-0.032842133194208145,
-0.01899717003107071,
0.010583593510091305,
-0.018121549859642982,
-0.017969267442822456,
-0.01394648663699627,
-0.00019064983644057065,
0.027842212468385696,
0.007087454665452242,
-0.029187368229031563,
-0.022296611219644547,
-0.012315800413489342,
0.03202996402978897,
0.0672578513622284,
-0.026420913636684418,
0.019885480403900146,
0.018921028822660446,
-0.0097650783136487,
-0.004498661961406469,
-0.01540585421025753,
-0.0004362242470961064,
0.012690160423517227,
0.03535478562116623,
0.008089977316558361,
0.0562935508787632,
-0.0053076595067977905,
0.02309609204530716,
-0.023717910051345825,
0.007201666012406349,
0.0038609812036156654,
-0.0018717986531555653,
-0.01782967522740364,
-0.04596376046538353,
0.0026141731068491936,
-0.011249827221035957,
-0.0015315436758100986,
-0.012791682034730911,
-0.08674993366003036,
0.017537802457809448,
0.029466552659869194,
-0.012353871017694473,
0.010012536309659481,
-0.009714317508041859,
-0.048501793295145035,
0.009358992800116539,
0.0014903007540851831,
-0.007100144866853952,
-0.0009454169194214046,
-0.002204915275797248,
-0.0073158773593604565,
-0.0243524182587862,
-0.005942167714238167,
-0.025621432811021805,
-0.01153535582125187,
0.0010405931388959289,
0.008952908217906952,
0.015456615015864372,
-0.04380643367767334,
0.016205335035920143,
0.008273984305560589,
0.008254949003458023,
0.0012412562500685453,
0.03659842163324356,
0.06477057933807373,
-0.0009136915323324502,
0.01361654233187437,
-0.027106182649731636,
-0.0011064233258366585,
-0.0007277014083229005,
0.008965598419308662,
0.01191606093198061,
0.03916183486580849,
0.01755049079656601,
0.03487256169319153,
0.029720354825258255,
0.011389418505132198,
0.014517543837428093,
-0.031877681612968445,
0.0732983648777008,
0.02817215584218502,
-0.06532894819974899,
0.02458084002137184,
-0.001146873226389289,
-0.0016925501404330134,
-0.002887011505663395,
-0.016751011833548546,
-0.010691460222005844,
-0.004771500360220671,
0.004834950901567936,
0.010976988822221756,
-0.019124072045087814,
-0.00986025482416153,
-0.03253757208585739,
0.007969420403242111,
0.04131916165351868,
-0.023426035419106483,
-0.022309301421046257,
-0.035507068037986755,
-0.01585000939667225,
0.022004738450050354,
0.00782982911914587,
0.005110961850732565,
0.01455561351031065,
-0.028832044452428818,
-0.020608820021152496,
0.0100950226187706,
-0.021497132256627083,
0.010444002225995064,
0.013502330519258976,
0.0025538946501910686,
0.015621587634086609,
0.03492332249879837,
-0.029694974422454834,
-0.029568074271082878,
-0.015113980509340763,
0.012696505524218082,
-0.009733352810144424,
-0.013984556309878826,
-0.027791451662778854,
-0.0005964375450275838,
0.023413345217704773,
0.03578625246882439,
0.00844530202448368,
0.012258694507181644,
-0.019682439044117928,
-0.02121794782578945,
0.028349818661808968,
-0.03449185565114021,
0.029060466215014458,
0.0345933772623539,
-0.04784190282225609,
-0.024428559467196465,
-0.007886935025453568,
0.02234737202525139,
-0.018641846254467964,
-0.01131327822804451,
0.009771423414349556,
-0.001740138279274106,
-0.003454896155744791,
0.029644213616847992,
0.02241082303225994,
0.02867976203560829,
-0.023794051259756088,
-0.009333613328635693,
0.0022778837010264397,
0.03870498761534691,
-0.028705142438411713,
-0.007569680456072092,
0.017855055630207062,
-0.004330517258495092,
0.04746120050549507,
-0.11015059053897858,
-0.02503768540918827,
-0.011497285217046738,
0.0006844755262136459,
-0.017766224220395088,
-0.013362739235162735,
0.002742660930380225,
0.024250896647572517,
0.015469305217266083,
0.021750934422016144,
0.016065742820501328,
-0.015240882523357868,
0.014022626914083958,
0.004714394453912973,
-0.021319469437003136,
-0.00951762031763792,
-0.01970781944692135,
-0.049973852932453156,
-0.020101213827729225,
0.035050224512815475,
0.006878066807985306,
0.017169786617159843,
0.0009390718769282103,
0.05053221806883812,
-0.0046731517650187016,
0.058120932430028915,
-0.07390749454498291,
0.004669979214668274,
-0.030634047463536263,
-0.053806278854608536,
0.0013062934158369899,
0.01359116192907095,
-0.018591085448861122,
0.028019873425364494,
0.02840057946741581,
-0.004393967799842358,
0.025621432811021805,
-0.01360385213047266,
0.014390641823410988,
0.02045653760433197,
0.0003408497723285109,
-0.017677392810583115,
0.01902255043387413,
0.00879428070038557,
-0.003445378504693508,
0.03167463839054108,
-0.0008780004573054612,
-0.008191498927772045,
0.0042385137639939785,
-0.03012644127011299,
0.06065896525979042,
-0.03154774010181427,
-0.047791142016649246,
0.012962998822331429,
-0.03593853488564491,
-0.034517236053943634,
0.03466951847076416,
0.0034422059543430805,
0.01685253344476223,
0.012931273318827152,
-0.013426189310848713,
0.049491625279188156,
0.013654612936079502,
0.008140738122165203,
0.00806459691375494,
0.025342250242829323,
-0.003267716383561492,
0.045176971703767776,
-0.04136992245912552,
-0.010513797402381897,
-0.000386256753699854,
0.0040449886582791805,
-0.049491625279188156,
0.003136055776849389,
0.029263509437441826,
0.02285497821867466,
-0.02144637145102024,
-0.04266431927680969,
-0.011345003731548786,
0.034288812428712845,
0.030431004241108894,
-0.007633131463080645,
-0.011243482120335102,
0.031167034059762955,
-0.012499808333814144,
0.02216970920562744,
0.013375429436564445,
0.015786560252308846,
0.008965598419308662,
-0.008908492513000965,
-0.019086001440882683,
-0.018375352025032043,
-0.024174755439162254,
0.025393011048436165,
-0.0011928750900551677,
0.01689060404896736,
-0.018362661823630333,
-0.012112758122384548,
0.02359100803732872,
0.004781018011271954,
0.036699943244457245,
-0.0014712654519826174,
0.009067119099199772,
0.011186376214027405,
-0.0235656276345253,
-0.018870268017053604,
0.04654750972986221,
-0.012100067920982838,
-0.0361669585108757,
-0.03340050205588341,
0.03606543689966202,
-0.00914960540831089,
0.0317000187933445,
-0.009473204612731934,
0.028273677453398705,
-0.011738398112356663,
0.03225838765501976,
-0.030913230031728745,
-0.00988563522696495,
-0.008895802311599255,
0.03900955244898796,
0.02025349624454975,
-0.012829751707613468,
-0.004971370100975037,
0.00902270432561636,
0.015075910836458206,
0.009143260307610035,
0.01323583722114563,
0.00024488044437021017,
-0.0259767584502697,
-0.03649690002202988,
0.013578471727669239,
-0.0013792618410661817,
-0.01827383041381836,
0.015811940655112267,
0.017436280846595764,
0.013147005811333656,
0.005713744554668665,
0.03162388131022453,
0.010850086808204651,
-0.0036896641831845045,
-0.004577975254505873,
0.00769658200442791,
-0.0031043305061757565,
0.013007414527237415,
0.01359116192907095,
-0.0842626616358757,
0.02791835181415081,
0.002671278780326247,
0.003991055302321911,
-0.05350171774625778,
-0.010926228016614914,
0.02746150642633438,
0.040583133697509766,
0.010412276722490788,
0.03433957323431969,
0.03738521412014961,
-0.019898170605301857,
-0.014124148525297642,
0.03388272970914841,
-0.008343780413269997,
0.011091199703514576,
-0.002512651728466153,
-0.008210533298552036,
0.00964452140033245,
-0.012810716405510902,
-0.02908584661781788,
0.004701704252511263,
0.03517712280154228,
0.025672193616628647,
-0.020532678812742233,
-0.06375536322593689,
0.05852701887488365,
0.011160995811223984,
-0.026065589860081673,
-0.015126670710742474,
0.02043115720152855,
0.020634200423955917,
-0.0027648687828332186,
-0.012157173827290535,
-0.028806664049625397,
-0.005402835551649332,
0.036420758813619614,
0.0033819277305155993,
0.0337558276951313,
-0.02359100803732872,
0.015799250453710556,
0.009695282205939293,
0.0321822464466095,
0.0195301566272974,
-0.007379328366369009,
-0.019822031259536743,
-0.0021700174547731876,
0.053095631301403046,
0.01238559652119875,
0.014035317115485668,
-0.009390718303620815,
0.03512636199593544,
-0.06837458163499832,
-0.023882880806922913,
-0.01493631862103939,
0.03629385679960251,
0.03393349051475525,
-0.011465559713542461,
-0.010640699416399002,
0.026674717664718628,
0.021801695227622986,
-0.06025288254022598,
-0.012239659205079079,
0.04768962413072586,
-0.002671278780326247,
0.036217719316482544,
-0.04164910688996315,
0.0013935382012277842,
0.002230295678600669,
-0.0000790160775068216,
0.026826998218894005,
0.010412276722490788,
0.008851386606693268,
-0.0031995067838579416,
0.01491093821823597,
-0.03923797607421875,
0.007131869904696941,
0.0247711930423975,
-0.009834874421358109,
0.01760125160217285,
0.03751211240887642,
0.044923167675733566,
-0.01262036431580782,
0.006795580964535475,
-0.04766424372792244,
0.04720739647746086,
0.020278876647353172,
0.03946639969944954,
0.013375429436564445,
-0.013857655227184296,
-0.02020273543894291,
-0.045176971703767776,
0.0247711930423975,
-0.026573196053504944,
0.04751196131110191,
0.005314004607498646,
-0.018108859658241272,
-0.025646813213825226,
-0.02387019246816635,
0.00022326750331558287,
0.04408561810851097,
-0.022690007463097572,
0.0034136532340198755,
-0.016966745257377625,
-0.010754911229014397,
0.019162142649292946,
0.00685903150588274,
0.004251203499734402,
0.017740843817591667,
-0.007975765503942966,
0.024390488862991333,
0.016027672216296196,
0.032639093697071075,
-0.022969190031290054,
0.002441269578412175,
-0.0192890428006649,
-0.0017655185656622052,
0.024847334250807762,
0.03319745883345604,
0.005402835551649332,
-0.003286751452833414,
-0.028045253828167915,
-0.009117879904806614,
0.03784205764532089,
0.04268969967961311,
0.0058311284519732,
-0.006215006113052368,
-0.008800625801086426,
-0.00817246362566948,
-0.032106105238199234,
0.0015045771142467856,
-0.00548532186076045,
0.020266186445951462,
-0.024238206446170807,
-0.01539316400885582,
-0.011097544804215431,
0.0014791968278586864,
-0.0035373822320252657,
-0.006522742565721273,
-0.005494839511811733,
-0.002950462279841304,
-0.022106260061264038,
0.02692851983010769,
-0.007804448716342449,
-0.033298980444669724,
0.0073666381649672985,
0.009587416425347328,
-0.017474351450800896,
-0.019086001440882683,
-0.0177789144217968,
-0.000861344626173377,
-0.015596207231283188,
0.0012301524402573705,
-0.02143368124961853,
0.018184999004006386,
0.010761256329715252,
-0.02286766842007637,
-0.009378028102219105,
0.021332159638404846,
-0.027156943455338478,
-0.012696505524218082,
-0.048476412892341614,
0.032359909266233444,
-0.0059929280541837215,
-0.029720354825258255,
-0.012372906319797039,
0.02479657344520092,
-0.017398210242390633,
0.02845134027302265,
0.008845041505992413,
-0.010291719809174538,
0.012328490614891052,
-0.0061864531598985195,
-0.007493539713323116,
-0.00807728711515665,
-0.014403332024812698,
0.017626632004976273,
0.01095795352011919,
-0.01737282983958721,
-0.009447824209928513,
0.04109073802828789,
-0.008242258802056313,
-0.016027672216296196,
-0.02336258441209793,
-0.002016149228438735,
-0.0005349695566110313,
-0.0002623294130899012,
-0.006541777867823839,
-0.01118003111332655,
0.005580497905611992,
0.021484442055225372,
0.00662426371127367,
-0.007106489967554808,
-0.00903539452701807,
0.012334835715591908,
0.022042809054255486,
0.010862777009606361,
-0.011732053011655807,
0.03867960721254349,
0.003124952083453536,
-0.0027077628765255213,
0.0007086661644279957,
-0.01685253344476223,
-0.016230715438723564,
0.058882344514131546,
-0.00499357795342803,
-0.022550415247678757,
0.035024844110012054,
0.02458084002137184,
0.006827306468039751,
0.0355578288435936,
-0.009054429829120636,
-0.016281476244330406,
0.0009033808019012213,
-0.017144406214356422,
-0.02096414566040039,
0.02162403240799904,
-0.016319546848535538,
-0.00474611995741725,
0.019428635016083717,
0.0007384087075479329,
-0.02289304882287979,
-0.022321991622447968,
0.013781514018774033,
-0.01394648663699627,
0.023007260635495186,
-0.022182399407029152,
-0.014745966531336308,
-0.010900847613811493,
-0.00039656751323491335,
0.023286445066332817,
0.022918429225683212,
-0.011078509502112865,
0.03690298646688461,
0.009562036022543907,
-0.026547815650701523,
0.0035215194802731276,
-0.017512422055006027,
0.01455561351031065,
0.011998546309769154,
-0.03733445331454277,
-0.02045653760433197,
0.008026526309549809,
0.0024809264577925205,
0.006554467603564262,
0.0023111954797059298,
0.014974389225244522,
-0.0291112270206213,
-0.0063196998089551926,
-0.03131931647658348,
-0.014149528928101063,
0.008997323922812939,
0.004368587862700224,
-0.0015823043650016189,
-0.0332736000418663,
0.007671202067285776,
0.025672193616628647,
-0.0066306088119745255,
0.0072587719187140465,
0.0005627293139696121,
-0.00414333725348115,
0.02001238241791725,
0.00385463610291481,
0.001794071402400732,
-0.015938840806484222,
0.02211895026266575,
-0.038425806909799576,
0.004121129401028156,
-0.0247711930423975,
-0.011383073404431343,
-0.003337512258440256,
-0.01973319984972477,
-0.01663680002093315,
-0.04548153281211853,
0.0025634123012423515,
0.015012459829449654,
0.015976911410689354,
-0.016509898006916046,
-0.021789005026221275,
-0.018692607060074806,
0.018717985600233078,
0.009238436818122864,
-0.010501107200980186,
0.007950385101139545,
0.034060388803482056,
0.020393088459968567,
0.015088601037859917,
-0.017931196838617325,
-0.01686522364616394,
-0.02093876525759697,
0.0027220393531024456,
-0.024263586848974228,
-0.016040362417697906,
-0.021014904603362083,
0.00216684490442276,
0.0427912212908268,
-0.00034937597229145467,
0.027994493022561073,
0.01394648663699627,
-0.012943963520228863,
-0.0032121967524290085,
-0.011700327508151531,
0.008394541218876839,
-0.017512422055006027,
0.011110235005617142,
0.0247711930423975,
-0.014136838726699352,
-0.0047048768028616905,
-0.005431388504803181,
0.02334989421069622,
-0.019200213253498077,
-0.01276630163192749,
0.0008026526193134487,
0.009555690921843052,
-0.007728307507932186,
0.009219401516020298,
0.013286598026752472,
0.02817215584218502,
0.017017504200339317,
0.02888280525803566,
0.0060532065108418465,
0.022042809054255486,
-0.03365430608391762,
0.04791804403066635,
-0.012144483625888824,
-0.0036484210286289454,
0.02114180661737919,
0.023755980655550957,
0.035710111260414124,
-0.012943963520228863,
0.004003745503723621,
0.010247304104268551,
0.0121762091293931,
-0.003251853631809354,
-0.0068146162666380405,
0.004895229358226061,
-0.0008510338957421482,
0.00009606847743270919,
-0.009276507422327995,
0.0317000187933445,
0.020507298409938812,
-0.027258465066552162,
0.02483464404940605,
0.022093569859862328,
-0.009187676012516022,
0.0015513721155002713,
-0.007683892268687487,
-0.034821800887584686,
0.002910805633291602,
0.009181330911815166,
0.007055729161947966,
-0.0023238856811076403,
-0.008616618812084198,
0.012074687518179417,
0.005818438716232777,
-0.011567081324756145,
0.018844887614250183,
0.017182476818561554,
-0.0002569757343735546,
0.0047905356623232365,
-0.006998623255640268,
-0.03540554642677307,
-0.008711795322597027,
0.0010191785404458642,
-0.033603545278310776,
0.01927635259926319,
0.00987294502556324,
-0.013286598026752472,
0.02604020945727825,
-0.01705557480454445,
-0.016078433021903038,
0.01611650362610817,
-0.00727146165445447,
-0.031116273254156113,
0.022981880232691765,
0.0066306088119745255,
0.01903524063527584,
-0.018476873636245728,
-0.0027331432793289423,
-0.026141731068491936,
0.0088894572108984,
0.015570826828479767,
-0.006567157804965973,
0.011605151928961277,
0.024593530222773552,
-0.012791682034730911,
0.006189625710248947,
-0.007702927105128765,
-0.017195167019963264,
0.03753749281167984,
-0.006700404454022646,
0.0013015345903113484,
0.016700251027941704,
-0.021979358047246933,
-0.030202582478523254,
0.0002645105414558202,
0.018337281420826912,
0.003337512258440256,
0.006332390010356903,
0.05083678290247917,
0.005044338759034872,
-0.006065896712243557,
-0.0004988819127902389,
-0.001341191353276372,
0.0271823238581419,
-0.009238436818122864,
-0.02890818566083908,
0.002807697979733348,
0.0015751661267131567,
-0.025837166234850883,
0.012518842704594135,
0.003018671879544854,
-0.027639169245958328,
-0.006081759463995695,
0.017245927825570107,
0.013261217623949051,
0.00566298421472311,
-0.01850225403904915,
-0.026420913636684418,
-0.010164818726480007,
0.0005841439706273377,
-0.02163672260940075,
-0.011097544804215431,
-0.004194098059087992,
0.019872790202498436,
0.01706826500594616,
0.012169864028692245,
-0.01804540865123272,
0.005028476007282734,
-0.0033882728312164545,
0.018844887614250183,
0.003508829278871417,
0.01370537281036377,
-0.006960553117096424,
-0.009581071324646473,
0.00613251980394125,
-0.0323091484606266,
-0.011484595015645027,
-0.025189967826008797,
-0.03258833289146423,
-0.036014676094055176,
0.05058297887444496,
0.0028473546262830496,
0.0009438307024538517,
-0.053298674523830414,
-0.024466628208756447,
0.029187368229031563,
0.0012951894896104932,
0.011522665619850159,
-0.01275361143052578,
-0.0140733877196908,
0.00901001412421465,
-0.01993624120950699,
-0.003794357879087329,
-0.00964452140033245,
0.024174755439162254,
-0.006770200561732054,
-0.0020653235260397196,
-0.00052783137653023,
-0.023299135267734528,
0.013806894421577454,
-0.007442778907716274,
-0.05735952407121658,
-0.011509975418448448,
-0.0620802640914917,
0.025938687846064568,
0.002902874257415533,
-0.004657289013266563,
0.03296903520822525,
-0.004460591357201338,
-0.029441172257065773,
0.014327190816402435,
-0.00021831040794495493,
0.0037626326084136963,
0.03834966570138931,
0.0352025032043457,
-0.001732206903398037,
-0.004850813653320074,
0.0013435707660391927,
0.028273677453398705,
0.004689014051109552,
0.015050530433654785,
0.05103982612490654,
-0.010520142503082752,
0.001279326737858355,
0.004508179612457752,
-0.002196983899921179,
-0.006598883308470249,
0.008293019607663155,
-0.011103889904916286,
-0.028045253828167915,
0.03771515563130379,
-0.024593530222773552,
0.013108935207128525,
-0.018844887614250183,
0.0509890653192997,
-0.0009612796711735427,
0.015190121717751026,
-0.011909715831279755,
0.020519988611340523,
0.002182707656174898,
-0.006364115513861179,
0.022537725046277046,
-0.015697728842496872,
0.0014791968278586864,
0.007487194612622261,
0.003280406352132559,
0.003997400403022766,
0.0187433660030365,
0.01781698502600193,
0.018832197412848473,
0.011275207623839378,
-0.019885480403900146,
-0.008832351304590702,
0.010735875926911831,
0.009194021113216877,
0.0021985701750963926,
0.024631600826978683,
-0.01873067580163479,
0.018667226657271385,
0.0180200282484293,
0.018235759809613228,
-0.002958393655717373,
-0.004105266649276018,
-0.024123994633555412,
0.003613523207604885,
-0.01373075321316719,
0.005977065302431583,
0.10466844588518143,
-0.03012644127011299,
-0.0161545742303133,
0.022474274039268494,
-0.045176971703767776,
0.003550072433426976,
0.018921028822660446,
-0.004520869813859463,
0.002466649981215596,
-0.015126670710742474,
0.02025349624454975,
0.015786560252308846,
-0.008908492513000965,
0.06228330731391907,
0.012004891410470009,
-0.022220470011234283,
0.006928827613592148,
0.023730600252747536,
-0.023527557030320168,
0.011586116626858711,
-0.0066813696175813675,
0.01661141961812973,
-0.0271823238581419,
0.023679839447140694,
-0.02359100803732872,
0.0019875962752848864,
-0.010393241420388222,
-0.017030194401741028,
-0.022283921018242836,
0.011998546309769154,
0.02117987722158432,
-0.006303837057203054,
0.02433972805738449,
-0.013857655227184296,
-0.0024999615270644426,
-0.003943467512726784,
-0.02553260326385498,
-0.03301979601383209,
-0.016230715438723564,
0.02072303183376789,
0.01082470640540123,
-0.01035517081618309,
-0.007867899723351002,
0.025189967826008797,
0.00903539452701807,
0.010056952014565468,
-0.044161759316921234,
0.0023222994059324265,
0.02238544262945652,
-0.01191606093198061,
0.013070865534245968,
0.0012372906785458326,
0.012169864028692245,
-0.006884411908686161,
-0.017981957644224167,
-0.023286445066332817,
0.030024919658899307,
-0.02187783643603325,
-0.002861631102859974,
-0.04411099851131439,
0.006668679416179657,
0.011877990327775478,
0.035989295691251755,
0.001456195954233408,
0.028984326869249344
] | 2024-07-11 | 67 | 38987430 | [
"iNFPA cells",
"tumor cell proliferation",
"cell samples",
"CD87 expression",
"iNFPAs cells",
"anti-CD87 BiTE",
"CD87",
"exerted satisfactory cytotoxic effects",
"CAR/IL-12 T cells",
"existing tumors",
"solid tumors",
"hematological tumors",
"high expression",
"CD87-specific CAR/IL-12 T cells",
"iNFPA tissue",
"CD87 CAR/IL-12 T-cells",
"high therapeutic efficacy",
"chimeric antigen receptor-modified T cells",
"invasive nonfunctioning pituitary adenomas",
"bispecific T-cell engagers",
"iNFPA",
"iNFPAs",
"CD87-specific BiTE",
"CD87×CD3 BiTE",
"noncancerous brain samples",
"experimental mice",
"mouse models",
"BiTE",
"antigenic specificity",
"their cytotoxic effects"
] | [
"CD87",
"Warburg effect",
"bispecific T cell engager",
"chimeric antigen receptor T cells",
"invasive non-functional pituitary adenomas"
] | 0 | 10.1007/s11427-024-2591-7
10.1038/s41467-020-20599-x
10.1001/jamaoncol.2017.0184
10.1111/jcmm.12617
10.1080/00365521.2020.1849383
10.1158/1078-0432.CCR-15-1696
10.7150/thno.47525
10.3390/cells9020308
10.1007/s00018-020-03707-4
10.1182/blood-2016-01-690743
10.2174/138161211796718233
10.1056/NEJMoa1610497
10.1038/nbt.4096
10.1158/2159-8290.CD-NB2017-155
10.1158/1078-0432.CCR-18-1811
10.1002/ijc.20077
10.1160/TH05-01-0054
10.1038/nrendo.2014.64
10.1038/nbt.3155
10.1074/jbc.M109.077677
10.1158/0008-5472.CAN-03-2904
10.1038/s41571-020-0347-5
10.1097/CJI.0000000000000260
10.1158/1078-0432.CCR-08-0096
10.1016/j.ab.2011.03.013
10.1016/j.ccr.2006.08.026
10.1038/leu.2010.75
10.1080/17446651.2017.1306439
10.1038/s41467-021-21246-9
10.1056/NEJMoa1609783
10.1089/hum.2018.180
10.1158/1055-9965.EPI-10-1009
10.1002/ijc.30817
10.1038/s41423-020-0417-8
10.7150/ijbs.63181
10.18632/oncotarget.1862
10.1007/s00401-017-1769-8
10.1038/sj.gt.3302456
10.1097/00006123-200208000-00047
10.1158/1078-0432.CCR-07-4863
10.1038/nrendo.2011.40
10.1074/jbc.M909575199
10.1126/scitranslmed.aaa0984
10.1172/JCI84813
10.1038/cddis.2015.202
10.1182/blood.2019003342
10.1016/S0021-9258(18)52382-6
10.1074/jbc.M005993200
10.1074/jbc.RX120.015588
10.1016/j.cell.2013.08.021
10.1158/1535-7163.MCT-05-0082
10.18632/oncotarget.25647
10.3171/jns.1986.65.6.0733
10.1200/JCO.2006.05.6853
10.1158/2159-8290.CD-17-0538
10.1016/S1470-2045(19)30823-X
10.18632/aging.100296
10.1007/s12022-013-9286-3
10.1016/S0002-9440(10)61773-7
10.1083/jcb.100.1.86
10.1182/blood-2017-06-741058
10.1182/blood-2011-02-337360
10.1158/2159-8290.CD-21-0316
10.3389/fnagi.2017.00435
10.1038/s41591-019-0421-7
10.1002/onco.13750
10.1159/000491071 | [
"Ren",
"Bao",
"Feng",
"Xing",
"Lian",
"Yao",
"Wang"
] | [
"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.",
"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.",
"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.",
"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.",
"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.",
"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.",
"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. [email protected]."
] | [
"38987430",
"33469002",
"28426845",
"33245246",
"26861458",
"33391466",
"32012858",
"33237352",
"27268090",
"21711239",
"28029927",
"29608179",
"30617136",
"15841311",
"24821329",
"25690852",
"20501655",
"15172999",
"32242094",
"30882547",
"18794088",
"19082473",
"21402045",
"17097563",
"20428207",
"30063429",
"33597522",
"28249141",
"30860401",
"8232800",
"21239684",
"28577299",
"32313210",
"34803504",
"24797434",
"28821944",
"15674398",
"12197494",
"18794071",
"21423242",
"10777511",
"28724573",
"27760047",
"26225774",
"32040549",
"1846368",
"11085980",
"32917829",
"11956102",
"23992846",
"16170032",
"30034627",
"3095506",
"17264329",
"28830878",
"32135120",
"21422497",
"24362581",
"11549590",
"3880760",
"29118005",
"21653320",
"34417225",
"29358916",
"31011207",
"33687124",
"29961070"
] | [] | 9.601897 | 5.922667 |
38986820 | 739 | BCL6 overexpression in CD4 | PDAC is a typical "cold tumor" characterized by low immune cell infiltration and a suppressive immune microenvironment. We previously observed the existence of a rare group of follicular helper T cells (Tfh) that could enhance antitumor immune responses by recruiting other immune cells in PDAC. In this study, we ectopically expressed BCL6 in CD4 | [
0.0077563319355249405,
-0.03301963210105896,
0.05382099002599716,
0.07946927100419998,
0.03112630546092987,
0.020321715623140335,
0.007396599743515253,
0.05026153475046158,
-0.005474872421473265,
-0.013669825159013271,
-0.031101061031222343,
0.01757008023560047,
0.01067205611616373,
-0.015903951600193977,
0.02627938613295555,
0.016080662608146667,
0.048595406115055084,
-0.003944432362914085,
0.018188565969467163,
0.04082014039158821,
0.004480875097215176,
-0.010993922129273415,
-0.01587870717048645,
-0.02466374635696411,
-0.028096981346607208,
-0.02486570179462433,
-0.012672672048211098,
0.007169400341808796,
0.021116914227604866,
-0.006431002635508776,
0.028046492487192154,
-0.010918188840150833,
-0.032615721225738525,
-0.0018822831334546208,
-0.02405788190662861,
0.00043704311246983707,
0.035569313913583755,
0.007674287538975477,
-0.010836144909262657,
-0.010211346670985222,
0.024625880643725395,
-0.0016961059300228953,
0.006759179290384054,
0.056850314140319824,
0.0071504670195281506,
-0.0435970239341259,
0.025900721549987793,
-0.03392843157052994,
0.028728090226650238,
-0.002983568701893091,
-0.01909736357629299,
0.04107258468866348,
-0.01587870717048645,
0.09254585206508636,
-0.07931780070066452,
0.04430386424064636,
0.0018475721590220928,
0.006453091278672218,
-0.012148851528763771,
-0.0011888518929481506,
0.02905626781284809,
-0.01215516310185194,
0.02000616118311882,
0.005932426545768976,
-0.022896641865372658,
-0.045717548578977585,
-0.03541784733533859,
-0.015197109431028366,
0.042915426194667816,
-0.03632664307951927,
-0.006506735924631357,
-0.021205268800258636,
-0.013707691803574562,
-0.004256831482052803,
0.06644317507743835,
0.017633190378546715,
0.026759030297398567,
-0.023262685164809227,
-0.04109783098101616,
0.00788886472582817,
0.03779081627726555,
0.051902420818805695,
0.004619719460606575,
-0.035746023058891296,
0.028753334656357765,
-0.04061818867921829,
-0.0028699690010398626,
0.006765490397810936,
-0.05533565208315849,
-0.008538907393813133,
0.047863319516181946,
0.009087972342967987,
-0.022480109706521034,
0.053518060594797134,
-0.02834942378103733,
0.014995153993368149,
-0.019804205745458603,
-0.0258376095443964,
0.01909736357629299,
0.041501741856336594,
0.028197959065437317,
-0.0038750104140490294,
-0.020927580073475838,
-0.052710238844156265,
0.005537983030080795,
-0.014010624028742313,
-0.06200016662478447,
-0.01615639589726925,
0.021154779940843582,
0.046525370329618454,
0.06548389047384262,
0.0157146193087101,
-0.05533565208315849,
0.018718698993325233,
-0.036553844809532166,
-0.040062811225652695,
0.0028068581596016884,
0.01340475957840681,
0.010104058310389519,
0.0046165636740624905,
-0.008595706894993782,
0.05149850994348526,
-0.006689757574349642,
0.0012606405653059483,
-0.010526901111006737,
-0.01336689293384552,
0.06139430031180382,
-0.048595406115055084,
-0.04114831984043121,
-0.06563535332679749,
0.020574159920215607,
-0.02862711250782013,
0.02915724366903305,
-0.013530980795621872,
-0.020523671060800552,
-0.02530747838318348,
0.029232976958155632,
0.010899255983531475,
-0.019791584461927414,
-0.01336689293384552,
0.056294940412044525,
-0.001768683549016714,
0.053063660860061646,
-0.031631194055080414,
-0.042562004178762436,
-0.05195290967822075,
-0.0019390829838812351,
-0.018769187852740288,
0.002057415898889303,
0.04771185293793678,
-0.03473624959588051,
0.04008805379271507,
0.035922735929489136,
-0.011959519237279892,
-0.039431702345609665,
-0.006320558488368988,
0.03473624959588051,
0.01462911069393158,
-0.03541784733533859,
-0.057102758437395096,
-0.039709389209747314,
-0.005837759934365749,
-0.0044051422737538815,
0.0020242827013134956,
0.029712621122598648,
0.02648134157061577,
-0.02179851196706295,
0.024184104055166245,
-0.05902133136987686,
-0.010703612118959427,
-0.038623880594968796,
-0.016219506040215492,
-0.04773709923028946,
0.022215044125914574,
-0.05331610515713692,
-0.0073839775286614895,
0.00006261786620598286,
0.019867317751049995,
-0.04102209582924843,
-0.06785686314105988,
0.005001540295779705,
0.05392196774482727,
0.0727037787437439,
-0.026153163984417915,
-0.03715970739722252,
-0.015133998356759548,
0.011726008728146553,
0.019627496600151062,
-0.05003433674573898,
0.005014162510633469,
0.008810284547507763,
-0.03993659093976021,
0.0511198453605175,
-0.0032565235160291195,
0.01194058544933796,
0.004054876510053873,
0.05377050116658211,
0.02171015553176403,
0.014061112888157368,
-0.009933658875524998,
0.011801742017269135,
0.008538907393813133,
-0.062303099781274796,
-0.007630110252648592,
-0.021647045388817787,
0.001360829221084714,
-0.011145387776196003,
-0.003310167696326971,
0.02118002437055111,
-0.0003370517515577376,
0.019046874716877937,
-0.031000083312392235,
0.0002723630459513515,
0.002461325842887163,
-0.007655354216694832,
-0.04142600670456886,
0.024373436346650124,
0.04945371672511101,
0.054224900901317596,
-0.0041306097991764545,
0.011240054853260517,
0.009674903936684132,
0.02270730771124363,
0.006803357042372227,
-0.02718818373978138,
-0.012243518605828285,
0.010697300545871258,
-0.021230513229966164,
-0.042208582162857056,
0.008097130805253983,
0.021053802222013474,
0.0008914417121559381,
-0.006872779224067926,
-0.03577126935124397,
-0.019539140164852142,
0.035316869616508484,
0.03387794271111488,
-0.005727315787225962,
0.05740569159388542,
-0.042940668761730194,
-0.03385269641876221,
0.012855693697929382,
0.011265299282968044,
0.03448380529880524,
-0.022101443260908127,
0.01676226034760475,
0.029535910114645958,
-0.038346193730831146,
-0.0028494580183178186,
-0.008702995255589485,
-0.01305133756250143,
-0.0026853696908801794,
-0.03301963210105896,
-0.028046492487192154,
-0.002218348905444145,
0.011909030377864838,
0.042284317314624786,
-0.013619336299598217,
-0.01956438459455967,
0.01999353989958763,
-0.03291865438222885,
0.04099685326218605,
-0.006715001538395882,
-0.04162796214222908,
-0.03125252574682236,
-0.007838375866413116,
0.030267996713519096,
-0.015146620571613312,
-0.01982945017516613,
0.04233480244874954,
0.009081660769879818,
0.035316869616508484,
0.04862065240740776,
-0.010362813249230385,
-0.011416764929890633,
0.01749434694647789,
0.01259693969041109,
0.0037077665328979492,
-0.01624475046992302,
0.007566999178379774,
-0.02217717655003071,
-0.0049573625437915325,
-0.017267147079110146,
0.002892057877033949,
-0.022808285430073738,
-0.00024021592980716377,
-0.015323330648243427,
-0.019955672323703766,
0.009428771212697029,
-0.026077430695295334,
0.006443624850362539,
-0.028223203495144844,
0.0021599712781608105,
-0.01283045019954443,
-0.02081398107111454,
0.017873011529445648,
0.0010429079411551356,
-0.04599523916840553,
-0.006011315155774355,
0.03864912688732147,
-0.05170046538114548,
0.005023628938943148,
-0.02547156624495983,
-0.017342880368232727,
0.04576803743839264,
0.014717466197907925,
-0.015992306172847748,
-0.01668652705848217,
0.01912260800600052,
0.034332338720560074,
0.014427156187593937,
0.004004387650638819,
-0.0029977685771882534,
0.03322158753871918,
0.013089204207062721,
0.011265299282968044,
0.018365276977419853,
-0.024083126336336136,
-0.006746557075530291,
-0.048216741532087326,
-0.057203736156225204,
-0.008772417902946472,
-0.05563858523964882,
-0.0005415705963969231,
0.01283045019954443,
-0.026127919554710388,
0.011662897653877735,
0.008803972974419594,
0.02968737669289112,
-0.023994771763682365,
0.02754160575568676,
-0.018592476844787598,
0.04995860159397125,
0.012085740454494953,
0.0026475030463188887,
-0.030520441010594368,
0.0029804131481796503,
0.0033322565723210573,
-0.017557457089424133,
0.0663926899433136,
0.000161425894475542,
0.023212196305394173,
-0.02898053452372551,
-0.01777203381061554,
0.037917040288448334,
0.04018903151154518,
0.01767105795443058,
0.06841223686933517,
-0.005282383877784014,
-0.004651274532079697,
0.02253059856593609,
0.02018287219107151,
0.051372285932302475,
-0.01027445774525404,
0.0004102209641132504,
-0.0023713926784694195,
-0.007106289267539978,
-0.0559920072555542,
0.01811283454298973,
0.0308738611638546,
0.027061961591243744,
0.0014136845711618662,
-0.00838744081556797,
0.04781283065676689,
0.006039714906364679,
0.04437959939241409,
-0.036402378231287,
-0.018441010266542435,
-0.053164638578891754,
-0.011606098152697086,
-0.009977836161851883,
0.02028384990990162,
0.0230733510106802,
-0.0017702612094581127,
-0.020245982334017754,
0.024701613932847977,
0.036023713648319244,
-0.006001848261803389,
0.02106642536818981,
0.027844537049531937,
0.04064343124628067,
-0.04798954352736473,
0.03940645605325699,
0.013038715347647667,
0.01822643354535103,
0.012224584817886353,
0.014856310561299324,
-0.05159948766231537,
-0.08164028078317642,
0.019627496600151062,
0.04458155110478401,
-0.021407224237918854,
0.039431702345609665,
-0.002835257910192013,
-0.04907505214214325,
0.006355269346386194,
-0.028677601367235184,
0.053063660860061646,
0.018857542425394058,
0.04738367721438408,
-0.03251474350690842,
-0.022644197568297386,
0.0165981724858284,
-0.03354976326227188,
0.026759030297398567,
-0.00798353087157011,
0.011542987078428268,
-0.003714077640324831,
0.013354270718991756,
-0.05437636747956276,
0.01524759829044342,
-0.008267530240118504,
-0.003436389612033963,
0.03549358248710632,
0.010476412251591682,
-0.010078813880681992,
-0.032716698944568634,
0.05094313248991966,
-0.0048185186460614204,
0.019602252170443535,
0.002863657893612981,
0.0016724393935874104,
-0.011650275439023972,
-0.018908031284809113,
0.004846918396651745,
0.013960135169327259,
0.016623415052890778,
0.03506442531943321,
0.0034647893626242876,
-0.053972456604242325,
0.03211083635687828,
0.022732552140951157,
-0.04064343124628067,
-0.010880322195589542,
-0.018908031284809113,
0.005645271856337786,
-0.08320543169975281,
-0.01315231528133154,
-0.014124223962426186,
0.004853229504078627,
0.019072119146585464,
0.026683297008275986,
-0.004790118895471096,
-0.06467606872320175,
-0.009592860005795956,
0.00029504354461096227,
0.04945371672511101,
-0.03415562957525253,
0.007270377594977617,
-0.005998692940920591,
0.027617337182164192,
-0.019589629024267197,
-0.00920157227665186,
0.030343730002641678,
-0.012988227419555187,
-0.0012732627801597118,
0.016370972618460655,
-0.007478643674403429,
-0.01013561338186264,
-0.042940668761730194,
0.101583331823349,
-0.030343730002641678,
-0.03200985863804817,
-0.04036574438214302,
-0.041602715849876404,
0.04629816859960556,
0.011776497587561607,
0.011296854354441166,
-0.000482009636471048,
0.0027926580514758825,
0.010924500413239002,
-0.0062763807363808155,
0.015096131712198257,
0.012906182557344437,
-0.029586398974061012,
0.0038623881991952658,
0.036553844809532166,
-0.015083509497344494,
0.019425541162490845,
-0.013897024095058441,
0.0461467020213604,
-0.03251474350690842,
-0.008949127979576588,
-0.022543219849467278,
0.04314262419939041,
0.06432265043258667,
-0.009523437358438969,
0.01211098488420248,
0.0031239904928952456,
0.012950360774993896,
0.00919526070356369,
-0.0006595090962946415,
0.03415562957525253,
-0.013619336299598217,
-0.012552761472761631,
-0.014427156187593937,
-0.004597630351781845,
0.003720388747751713,
0.038447171449661255,
0.014124223962426186,
-0.002811591373756528,
0.035215891897678375,
0.006563535425812006,
0.0028983689844608307,
0.043824221938848495,
0.04003756493330002,
-0.00167086161673069,
0.027920270338654518,
-0.0022262376733124256,
0.01054583489894867,
-0.009681214578449726,
0.04632341489195824,
0.0042599868029356,
-0.050539225339889526,
-0.022934507578611374,
-0.01036912389099598,
-0.02179851196706295,
-0.01027445774525404,
0.01359409186989069,
0.01413684617727995,
0.003313323250040412,
-0.012697916477918625,
-0.03415562957525253,
-0.0067213126458227634,
0.027617337182164192,
-0.02574925497174263,
-0.029838841408491135,
-0.04124929755926132,
-0.042915426194667816,
-0.017027325928211212,
0.009554993361234665,
-0.019539140164852142,
0.02547156624495983,
0.007541754748672247,
-0.002963057719171047,
-0.012300318107008934,
0.00428207591176033,
0.0016172173200175166,
-0.03158070519566536,
-0.020952824503183365,
0.028298936784267426,
0.02592596597969532,
-0.021672289818525314,
0.001806550077162683,
0.011258987709879875,
0.010880322195589542,
0.019072119146585464,
0.0013758180430158973,
-0.011839608661830425,
-0.018529364839196205,
0.03912876918911934,
-0.02169753424823284,
-0.024562768638134003,
-0.002683791797608137,
0.006898023188114166,
0.0036257223691791296,
0.0075859325006604195,
-0.026052188128232956,
-0.009586548432707787,
-0.018453633412718773,
0.0006480702431872487,
0.011000232771039009,
0.0075228214263916016,
-0.02081398107111454,
0.0182011891156435,
0.03723544254899025,
0.0014010623563081026,
0.0075543769635260105,
0.0015738285146653652,
0.03958316892385483,
-0.04907505214214325,
0.008652507327497005,
-0.03362549841403961,
-0.027516361325979233,
0.01884492114186287,
0.011517742648720741,
-0.029712621122598648,
0.02154606766998768,
-0.001621950650587678,
-0.026228897273540497,
-0.014616488479077816,
0.007087355945259333,
0.00016546894039493054,
0.04026476666331291,
0.011246365495026112,
0.024108370766043663,
0.027844537049531937,
-0.012716850265860558,
0.001967482967302203,
-0.025181256234645844,
-0.004736474249511957,
-0.026052188128232956,
0.007081044837832451,
-0.008437929674983025,
-0.002620680956169963,
0.017973989248275757,
0.02386854961514473,
0.0016850614920258522,
-0.05008482560515404,
-0.0034931893460452557,
0.01067205611616373,
-0.0031618571374565363,
-0.021647045388817787,
-0.010053569450974464,
-0.010520590469241142,
0.024461792781949043,
0.002978835254907608,
0.005310783628374338,
0.0053612724877893925,
0.004550297278910875,
0.030848616734147072,
0.03165643662214279,
-0.00297252438031137,
-0.031202038750052452,
0.016913726925849915,
-0.0006835701642557979,
-0.03041946329176426,
-0.009883170016109943,
0.01251489482820034,
-0.035291627049446106,
-0.00668344646692276,
-0.0005912703927606344,
0.00005221442552283406,
-0.030621416866779327,
-0.032085590064525604,
-0.035392604768276215,
-0.039608411490917206,
0.0014215734554454684,
0.02485308051109314,
0.018870165571570396,
-0.0011004966218024492,
0.004427230916917324,
0.029737865552306175,
0.03582175821065903,
0.007137844804674387,
-0.0027263916563242674,
0.0163204837590456,
0.027970759198069572,
0.0069800675846636295,
-0.021381979808211327,
0.010741478763520718,
0.034862469881772995,
-0.00946032628417015,
-0.024651125073432922,
0.03912876918911934,
-0.007497576996684074,
0.00044887640979140997,
-0.02880382351577282,
0.025799743831157684,
-0.026784274727106094,
-0.0064688692800700665,
-0.031353503465652466,
0.02376757189631462,
0.04904980584979057,
-0.008759795688092709,
-0.011953207664191723,
-0.011896408163011074,
-0.001047641271725297,
0.009996769949793816,
0.05649689584970474,
-0.02933395467698574,
-0.01336689293384552,
0.02898053452372551,
-0.0034300785046070814,
-0.010709922760725021,
0.010047257877886295,
-0.02413361519575119,
-0.010331257246434689,
0.029182488098740578,
-0.00024356870562769473,
0.1051175445318222,
-0.0007021089550107718,
0.05861742049455643,
-0.007642732467502356,
0.009050105698406696,
-0.0011186409974470735,
-0.00480274111032486,
-0.0144397784024477,
-0.034761492162942886,
-0.014616488479077816,
0.004061187617480755,
0.03049519658088684,
-0.029131999239325523,
-0.013316404074430466,
0.002398215001448989,
-0.024777347221970558,
0.009662281721830368,
0.000482009636471048,
0.00788886472582817,
-0.022101443260908127,
-0.000002810408204823034,
-0.006929578725248575,
-0.01211098488420248,
0.0012369740288704634,
-0.007440777495503426,
-0.025900721549987793,
-0.00771846529096365,
0.003720388747751713,
-0.025812365114688873,
0.027061961591243744,
0.013657202944159508,
-0.037917040288448334,
0.02116740122437477,
-0.0001025552410283126,
0.023123839870095253,
-0.019248830154538155,
-0.019677983596920967,
0.021495578810572624,
0.020056650042533875,
-0.01211729645729065,
-0.029106754809617996,
0.0183147881180048,
-0.014098979532718658,
0.006677135359495878,
-0.0125590730458498,
-0.014376667328178883,
-0.022480109706521034,
0.07078520953655243,
0.011189565993845463,
-0.007440777495503426,
0.010160857811570168,
-0.022278154268860817,
0.011524053290486336,
-0.04314262419939041,
0.06396922469139099,
0.0033259454648941755,
-0.058819375932216644,
-0.005553761031478643,
-0.02088971436023712,
0.00035046282573603094,
-0.007806820794939995,
0.0025812366511672735,
0.0017371280118823051,
-0.04834296181797981,
-0.022467486560344696,
-0.004266297910362482,
-0.03031848557293415,
0.007491265889257193,
-0.02342677302658558,
-0.010823522694408894,
0.024285081773996353,
-0.009447704069316387,
-0.01902163028717041,
0.007737398613244295,
-0.03617518022656441,
0.01750696823000908,
0.009182638488709927,
0.005506427492946386,
-0.012502272613346577,
-0.04523790627717972,
0.02332579530775547,
0.009668592363595963,
-0.011044410988688469,
-0.0034679449163377285,
-0.016345728188753128,
-0.01570199616253376,
0.008810284547507763,
0.0020858158823102713,
-0.008097130805253983,
-0.020649893209338188,
0.017469102516770363,
-0.010280768387019634,
-0.01023027952760458,
-0.03337305411696434,
-0.035190649330616,
0.006399447098374367,
-0.008141308091580868,
-0.029207732528448105,
0.0041306097991764545,
-0.023401528596878052,
0.009043795056641102,
-0.025421077385544777,
0.01866821013391018,
-0.0031902568880468607,
0.02978835441172123,
0.033423542976379395,
0.009245749562978745,
-0.018996385857462883,
-0.022833529859781265,
-0.006961134262382984,
-0.004727007821202278,
-0.0046260301023721695,
-0.013038715347647667,
0.009662281721830368,
-0.03299438953399658,
-0.015260220505297184,
0.04917602613568306,
0.02088971436023712,
-0.013480491936206818,
-0.0021773267071694136,
0.010785656049847603,
0.03094959445297718,
-0.011139077134430408,
0.03445856273174286,
0.014818443916738033,
0.0323127917945385,
0.04493497312068939,
-0.09572663903236389,
-0.020599404349923134,
-0.008046641945838928,
0.03006604127585888,
-0.02253059856593609,
-0.00041337651782669127,
0.04718172177672386,
0.0016803281614556909,
0.007907798513770103,
0.0002765047247521579,
0.011776497587561607,
0.009087972342967987,
0.024991923943161964,
-0.023906415328383446,
-0.025004545226693153,
0.003537367098033428,
-0.0012235629837960005,
-0.045793283730745316,
0.027213428169488907,
0.0029457020573318005,
-0.03410514071583748,
-0.005569538567215204,
-0.0028321025893092155,
0.044632039964199066,
-0.019892562180757523,
0.03165643662214279,
-0.04672732576727867,
0.009851614013314247,
-0.02333841845393181,
0.011498809792101383,
0.007699531968683004,
-0.02520650066435337,
-0.03195936977863312,
0.004045410081744194,
-0.05276072770357132,
-0.028298936784267426,
0.011965829879045486,
-0.01821381039917469,
-0.015853462740778923,
0.01730501465499401,
-0.0023303707130253315,
0.005260295234620571,
-0.023262685164809227,
0.041400764137506485,
0.0074155330657958984,
-0.012085740454494953,
-0.04667683690786362,
0.016004929319024086,
-0.017267147079110146,
-0.013695069588720798,
0.022745175287127495,
-0.027339650318026543,
-0.003477411577478051,
0.011631342582404613,
-0.0033669674303382635,
-0.052710238844156265,
-0.014565999619662762,
0.011726008728146553,
0.011593475937843323,
0.0003583516809158027,
-0.014490267261862755,
0.06442362815141678,
0.044531065970659256,
-0.007238822523504496,
-0.026784274727106094,
-0.007510199211537838,
0.014477645047008991,
0.04952944815158844,
-0.060435015708208084,
-0.008191796950995922,
0.015765108168125153,
0.004992073867470026,
0.015310708433389664,
0.021912110969424248,
-0.00029445189284160733,
-0.015601019375026226,
-0.019980916753411293,
-0.021849000826478004,
-0.017986612394452095,
-0.007434466388076544,
-0.0010421189945191145,
-0.02673378586769104,
-0.009472948499023914,
0.03428184986114502,
0.012779961340129375,
0.0035247448831796646,
0.011997385881841183,
0.02539583295583725,
0.026329874992370605,
0.0051498510874807835,
0.02287139743566513,
-0.028652356937527657,
-0.04246102645993233,
-0.003212345764040947,
0.006418380420655012,
-0.016800126060843468,
-0.025812365114688873,
0.020258605480194092,
0.019135231152176857,
-0.010684678331017494,
0.04334457963705063,
-0.012710538692772388,
-0.034660518169403076,
-0.018352655693888664,
-0.01595444045960903,
-0.01440191175788641,
0.005004695616662502,
-0.027693070471286774,
-0.03688202053308487,
-0.03094959445297718,
0.05634542927145958,
0.008778728544712067,
0.010760411620140076,
-0.008652507327497005,
-0.0288795568048954,
0.039709389209747314,
0.016547683626413345,
0.015941817313432693,
0.012817827984690666,
-0.03885108232498169,
0.033070120960474014,
0.003982299007475376,
0.013202804140746593,
0.02549681067466736,
0.004499808419495821,
0.0005553760565817356,
0.02521912381052971,
0.027945514768362045,
-0.040340498089790344,
0.009403526782989502,
-0.012527517043054104,
0.0012645850656554103,
-0.00829277466982603,
0.01373293623328209,
0.011789119802415371,
0.029737865552306175,
0.0038781659677624702,
0.06154576689004898,
0.017267147079110146,
0.022391753271222115,
0.040416233241558075,
-0.029460176825523376,
-0.016800126060843468,
-0.022846153005957603,
-0.006213270127773285,
0.0015051953960210085,
-0.04061818867921829,
0.022379131987690926,
0.01991780661046505,
0.02385592646896839,
0.017734168097376823,
-0.008166552521288395,
0.019223585724830627,
0.03796752914786339,
-0.007661665324121714,
0.028829067945480347,
0.03445856273174286,
-0.0009577081655152142,
0.004427230916917324,
0.04109783098101616,
-0.029712621122598648,
0.01768367923796177,
0.022745175287127495,
-0.029838841408491135,
0.006061803549528122,
-0.02250535413622856,
-0.0008338530315086246,
0.00977588165551424,
0.023527750745415688,
0.001117063220590353,
0.02610267512500286,
-0.040769655257463455,
0.04316786676645279,
-0.0023777037858963013,
-0.04551559314131737,
0.019274074584245682,
0.00893019512295723,
0.022126687690615654,
0.002871546894311905,
0.0038781659677624702,
-0.02188686653971672,
0.03842192888259888,
0.048595406115055084,
-0.02217717655003071,
0.021129535511136055,
-0.019867317751049995,
0.03178265690803528,
-0.006292158737778664,
0.01036912389099598,
-0.02630463056266308,
0.018163321539759636,
-0.02116740122437477,
0.03125252574682236,
0.0006058647995814681,
0.024108370766043663,
-0.008986994624137878,
-0.033347807824611664,
0.06275749951601028,
-0.029990307986736298,
-0.026834761723876,
-0.004193720407783985,
0.028904801234602928,
0.02870284579694271,
-0.013871779665350914,
-0.030267996713519096,
0.030293241143226624,
0.040062811225652695,
-0.06144478917121887,
-0.017519591376185417,
0.050286781042814255,
-0.012906182557344437,
0.021281002089381218,
-0.025269612669944763,
0.010741478763520718,
0.02951066568493843,
-0.010482723824679852,
0.006601402070373297,
0.019236208871006966,
-0.03582175821065903,
-0.003163434797897935,
-0.0012227740371599793,
-0.0617477223277092,
0.040592942386865616,
-0.005963981617242098,
-0.003288078820332885,
0.0051908730529248714,
0.046070970594882965,
0.016837993636727333,
-0.0392802357673645,
0.04243578016757965,
-0.037917040288448334,
0.04147649556398392,
0.025547299534082413,
0.056850314140319824,
-0.018428388983011246,
0.00313976826146245,
-0.012073119170963764,
-0.030545685440301895,
-0.021609177812933922,
-0.02585023269057274,
0.05129655450582504,
0.03678104281425476,
-0.013568847440183163,
-0.025345344096422195,
-0.019955672323703766,
-0.0012630072887986898,
0.016206884756684303,
-0.07320866733789444,
-0.0024487036280333996,
-0.02188686653971672,
0.01839052140712738,
-0.011240054853260517,
0.03160594776272774,
0.042839691042900085,
0.0050867400132119656,
0.01712830364704132,
0.006251136306673288,
-0.00013904123625252396,
0.03774033114314079,
0.0007143366965465248,
-0.020927580073475838,
-0.00731455534696579,
-0.002690102905035019,
0.001910683116875589,
0.013127070851624012,
0.013530980795621872,
-0.019147852435708046,
-0.020574159920215607,
-0.009529748931527138,
0.03680628910660744,
0.004644963424652815,
0.00956130400300026,
0.004597630351781845,
-0.01803710125386715,
0.03715970739722252,
-0.018340032547712326,
0.01120849885046482,
-0.003111368278041482,
-0.0037992773577570915,
-0.015992306172847748,
0.0001968271826626733,
-0.012628494761884212,
-0.0025701920967549086,
0.026860006153583527,
0.03294390067458153,
0.029485421255230904,
-0.02144508995115757,
-0.05220535025000572,
0.029864085838198662,
0.0011036521755158901,
-0.02961164340376854,
0.009769570082426071,
0.014982531778514385,
0.023830682039260864,
-0.009119527414441109,
-0.030545685440301895,
-0.03541784733533859,
-0.002537058899179101,
-0.004619719460606575,
-0.037008240818977356,
0.020700382068753242,
0.03309536725282669,
-0.0203595831990242,
-0.0005952148349024355,
0.02359086088836193,
-0.007194644771516323,
-0.018642965704202652,
-0.0427134707570076,
0.025724010542035103,
0.004597630351781845,
-0.02513076737523079,
-0.015525286085903645,
0.026860006153583527,
0.02216455526649952,
-0.017620569095015526,
0.010665745474398136,
-0.00862095132470131,
0.0056200274266302586,
0.009258371777832508,
-0.0314292386174202,
-0.019842073321342468,
0.0022704151924699545,
0.008336951956152916,
0.012565383687615395,
-0.015563152730464935,
0.009491882286965847,
0.02620365284383297,
0.01247702818363905,
0.01462911069393158,
-0.005616871640086174,
0.002816324820742011,
-0.012432850897312164,
0.008134997449815273,
-0.004730163142085075,
0.0031823681201785803,
0.026683297008275986,
-0.03274194523692131,
0.002961479825899005,
-0.011359965428709984,
0.004443008452653885,
-0.0031555460300296545,
0.004919495899230242,
0.023275306448340416,
0.018958520144224167,
-0.00017414668400306255,
0.018895408138632774,
0.029813598841428757,
-0.000628348090685904,
-0.003045101882889867,
-0.0355188250541687,
0.058011557906866074,
-0.044202886521816254,
-0.01669914834201336,
0.009801126085221767,
0.013669825159013271,
-0.008046641945838928,
0.017519591376185417,
0.01615639589726925,
-0.0010973410680890083,
0.02044793777167797,
-0.017961367964744568,
0.03829570487141609,
-0.020397448912262917,
-0.026784274727106094,
0.012843071483075619,
0.009706459008157253,
0.002773724962025881,
-0.030621416866779327,
0.015575774945318699,
-0.006550913210958242,
0.00839375238865614,
0.02253059856593609,
-0.013265915215015411,
-0.022808285430073738,
-0.017532212659716606,
-0.009977836161851883,
0.02485308051109314,
-0.03228754550218582,
-0.01507088728249073,
0.03852290287613869,
0.0017103059217333794,
-0.03986085578799248,
0.000929308298509568,
-0.028854312375187874,
-0.012754716910421848,
-0.025875477120280266,
0.002863657893612981,
0.0004658374818973243,
0.021949976682662964,
0.007156778126955032,
-0.010186102241277695,
0.0017907723085954785,
0.004805896431207657,
-0.010394368320703506,
-0.005111984442919493,
0.0023019707296043634,
0.0047554075717926025,
0.02539583295583725,
0.0008693528943695128,
0.006020781584084034,
-0.023792816326022148,
0.022126687690615654,
0.007106289267539978,
-0.007358733098953962,
-0.005809360183775425,
0.011202188208699226,
0.007125222589820623,
0.027213428169488907,
-0.011991074308753014,
0.03582175821065903,
-0.008785040117800236,
0.03516540303826332,
-0.05291219428181648,
0.01206049695611,
0.01802447810769081,
-0.005960826296359301,
0.012458095327019691,
-0.021735399961471558,
-0.018882786855101585,
-0.0035941668320447206,
-0.015916572883725166,
-0.007882554084062576,
0.011303165927529335,
-0.012508584186434746,
-0.006948512047529221,
-0.0012874627718701959,
0.014048490673303604,
-0.006696068681776524,
0.005632649641484022,
0.0019469718681648374,
0.03733642026782036,
0.0016866392688825727,
0.005705227144062519,
0.013089204207062721,
-0.02501716837286949,
-0.03413038328289986,
-0.032969143241643906,
-0.010053569450974464,
-0.021079046651721,
0.0164340827614069,
0.023982148617506027,
0.02341414988040924,
0.0040801209397614,
0.001618795096874237,
-0.006165936589241028,
-0.03337305411696434,
-0.013833913020789623,
0.0031303016003221273,
0.049933359026908875,
0.029636887833476067,
-0.002317748498171568,
0.009618104435503483,
-0.0401637889444828,
-0.013947512954473495,
-0.007049489766359329,
0.032716698944568634,
-0.004468252882361412,
-0.027238672599196434,
0.008078197948634624,
-0.01234449539333582,
-0.025951210409402847,
0.014717466197907925,
0.006771801505237818,
-0.00027137694996781647,
0.0035941668320447206,
0.019173096865415573,
0.008974372409284115,
0.016446705907583237,
-0.027794048190116882,
0.017204036936163902,
0.016749637201428413,
0.01211098488420248,
0.005036251153796911,
-0.03622566908597946,
0.011631342582404613,
-0.025774499401450157,
0.04667683690786362,
0.00035026558907702565,
0.0064467801712453365,
0.0154369305819273,
-0.05185193195939064,
-0.023906415328383446,
0.014654355123639107,
-0.012805205769836903,
-0.004477719776332378,
0.01050165668129921,
0.019778961315751076,
-0.03392843157052994,
0.0423852913081646,
0.020952824503183365,
-0.013379515148699284,
0.010874011553823948,
-0.021381979808211327,
-0.00412745401263237,
-0.0036414999049156904,
-0.0009340415708720684,
0.02189948968589306,
-0.0021662823855876923,
-0.004843763075768948,
0.020157627761363983,
-0.00437674205750227,
0.005370739381760359,
0.005096206907182932,
-0.010489034466445446,
-0.029232976958155632,
0.03365074098110199,
-0.01804972253739834,
-0.0340798944234848,
-0.007396599743515253,
0.013505736365914345,
-0.017443858087062836,
0.013644580729305744,
0.0016440394101664424,
0.002742169424891472,
-0.0015982839977368712,
0.011410454288125038,
-0.04720696806907654,
0.03392843157052994,
-0.007920420728623867,
0.004184253979474306,
0.002502347808331251,
0.02109166979789734,
0.024550147354602814,
-0.0496809147298336,
-0.007257755845785141,
-0.0314292386174202,
-0.028223203495144844,
0.030848616734147072,
-0.010432234965264797,
0.03561980277299881,
0.017708923667669296,
-0.01993042789399624,
0.054780278354883194,
0.013897024095058441,
-0.014452400617301464,
0.04682829976081848,
-0.006304780952632427,
-0.020801357924938202,
-0.004534519277513027,
0.001117063220590353,
-0.030469952151179314,
0.01757008023560047,
0.01900900900363922,
0.010078813880681992,
-0.008690373040735722,
0.05162473022937775,
0.03317109867930412,
-0.05392196774482727,
0.02189948968589306,
0.02152082324028015,
0.007693220861256123,
-0.02306072972714901,
0.029359199106693268,
0.007081044837832451,
-0.02206357754766941,
-0.03150497004389763,
0.012761027552187443,
-0.04251151531934738,
-0.02269468642771244,
-0.0013545181136578321,
0.0375131294131279,
0.0037077665328979492,
-0.009454015642404556,
-0.00016162311658263206,
-0.0038970992900431156,
0.008709306828677654,
-0.004793274216353893,
0.004026476759463549,
-0.05700178071856499,
0.01332902628928423,
-0.001378184650093317,
-0.04692927747964859,
0.013291159644722939,
-0.014502889476716518,
-0.025143390521407127,
0.027061961591243744,
0.022013088688254356,
-0.002590703312307596,
-0.003284923266619444,
-0.0077563319355249405,
-0.02441130392253399,
0.005878781899809837,
0.006342647131532431,
-0.015853462740778923,
-0.01259693969041109,
0.008955439552664757,
0.001301662647165358,
0.01828954368829727,
0.005957670509815216,
0.007964598014950752,
-0.04927700385451317,
-0.039684146642684937,
-0.0019485496450215578,
-0.00657615764066577,
-0.006254292093217373,
-0.0005064651486463845,
0.008488418534398079,
0.007825753651559353,
-0.035847000777721405,
0.014641732908785343,
-0.03329731896519661,
0.016547683626413345,
-0.010432234965264797,
-0.004379897844046354,
0.025976454839110374,
-0.016837993636727333,
-0.014427156187593937,
-0.018642965704202652,
-0.019627496600151062,
0.013758180662989616,
-0.015411686152219772,
0.0032628343906253576,
-0.0050772735849022865,
0.006475180387496948,
0.021104291081428528,
0.018706075847148895,
-0.029131999239325523,
0.0019185718847438693,
0.0211926456540823,
0.00207477156072855,
-0.008172864094376564,
0.028500890359282494,
0.006872779224067926,
-0.014995153993368149,
-0.007478643674403429,
0.012615872547030449,
-0.009984147734940052,
0.03158070519566536,
0.015462175011634827,
-0.022278154268860817,
0.006184869911521673,
0.022631576284766197,
0.007699531968683004,
-0.010287079960107803,
-0.02547156624495983,
-0.011631342582404613,
-0.0004997595679014921,
0.009700148366391659,
-0.02961164340376854,
0.009889480657875538,
-0.024272458627820015,
0.015386441722512245,
0.008406374603509903,
0.007667976431548595,
0.0023556151427328587,
0.03715970739722252,
0.027794048190116882,
0.004607097245752811,
-0.003518433775752783,
-0.022404376417398453,
0.005096206907182932,
0.015096131712198257,
-0.0004236320382915437,
0.05000909045338631,
0.004720696713775396,
0.028829067945480347,
0.017620569095015526,
-0.012660049833357334,
-0.004894251935184002,
-0.022833529859781265,
0.0403909869492054,
-0.00785099808126688,
0.035392604768276215,
0.025269612669944763,
-0.0023761261254549026,
-0.022593708708882332,
0.0052792285569012165,
0.01921096444129944,
0.002011660486459732,
-0.005007851403206587,
-0.016547683626413345,
-0.010419612750411034,
-0.012174095958471298,
0.014591244049370289,
0.08158979564905167,
-0.04213285073637962,
0.016749637201428413,
0.04675256833434105,
0.0009387749014422297,
-0.004824829753488302,
0.021482957527041435,
0.022846153005957603,
0.01830216683447361,
-0.028955290094017982,
0.026759030297398567,
-0.008406374603509903,
0.014755332842469215,
0.03357500955462456,
-0.01300084963440895,
-0.007737398613244295,
0.0068096681497991085,
0.04657585918903351,
-0.01803710125386715,
-0.0335245206952095,
0.011164321564137936,
0.018895408138632774,
-0.04344555735588074,
0.021836377680301666,
0.0055001163855195045,
0.017961367964744568,
-0.023540372028946877,
-0.025004545226693153,
-0.029662132263183594,
-0.0009829525370150805,
0.02978835441172123,
-0.005418072454631329,
0.023477261886000633,
-0.04324360191822052,
-0.015222353860735893,
-0.013985379599034786,
-0.017077814787626266,
-0.007371355313807726,
-0.027036717161536217,
0.03743739798665047,
-0.0008614640682935715,
0.03660433366894722,
-0.028096981346607208,
-0.0043735867366194725,
0.00249130348674953,
-0.009857925586402416,
-0.03195936977863312,
0.032691456377506256,
-0.00399492122232914,
-0.008191796950995922,
0.015462175011634827,
-0.0004374375566840172,
0.01774679124355316,
0.0220761988312006,
-0.012262451462447643,
-0.03703348711133003,
0.016383593901991844,
-0.004458786454051733,
-0.031454481184482574,
-0.03362549841403961,
-0.010457479394972324,
0.01946340687572956,
-0.002631725277751684,
0.009005928412079811,
0.011372587643563747
] | 2024-07-11 | 1 | 38986820 | [
"low immune cell infiltration",
"other immune cells",
"follicular helper T cells",
"antitumor immune responses",
"BCL6",
"CD4",
"PDAC",
"Tfh",
"a suppressive immune microenvironment",
"a rare group",
"a typical \"cold tumor",
"this study",
"the existence",
"We",
"that",
"we"
] | [
"BCL6",
"Cell therapy",
"Chimeric antigen receptor",
"Follicular helper T cells",
"Pancreatic ductal adenocarcinoma"
] | 0 | 10.1016/j.bbadis.2024.167346 | [
"Lin",
"Dai",
"Tasiheng",
"Zhang",
"Wang",
"Dong",
"Chen",
"Ma",
"Zou",
"Yan",
"Wang",
"Yu",
"Cheng",
"Liu"
] | [
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.",
"Department of Laboratory Medicine, Shanghai General Hospital, Shanghai, China.",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China; Cancer Research Institute, Shanghai Key Laboratory of Radiation Oncology, Cancer Research Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China. Electronic address: [email protected].",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. Electronic address: [email protected].",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. Electronic address: [email protected].",
"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. Electronic address: [email protected]."
] | [
"38986820"
] | [] | 9.499947 | 5.918628 |
38986621 | 740 | Chimeric antigen receptor-induced antigen loss protects CD5.CART cells from fratricide without compromising on-target cytotoxicity. | Chimeric antigen receptor T cells (CART) targeting lymphocyte antigens can induce T cell fratricide and require additional engineering to mitigate self-damage. We demonstrate that the expression of a chimeric antigen receptor (CAR) targeting CD5, a prominent pan-T cell antigen, induces rapid internalization and complete loss of the CD5 protein on T cells, protecting them from self-targeting. Notably, exposure of healthy and malignant T cells to CD5.CART cells induces similar internalization of CD5 on target cells, transiently shielding them from cytotoxicity. However, this protection is short-lived, as sustained activity of CD5.CART cells in patients with T cell malignancies results in full ablation of CD5 | [
0.020306268706917763,
0.028167126700282097,
-0.0015656303148716688,
0.05838194489479065,
-0.020909199491143227,
0.007775537669658661,
-0.009186169132590294,
0.02500458061695099,
-0.017928671091794968,
-0.02500458061695099,
0.009624147787690163,
0.0026108059100806713,
-0.020909199491143227,
0.02379871904850006,
0.02534586377441883,
-0.05779038742184639,
0.04850752279162407,
-0.01716647483408451,
-0.006734627764672041,
0.057335346937179565,
0.020715806633234024,
0.027643827721476555,
0.008549110032618046,
0.04909907653927803,
-0.012126880697906017,
-0.040385015308856964,
0.06202228367328644,
0.011762847192585468,
0.0007038937765173614,
-0.04548149183392525,
0.03053334727883339,
-0.02869042567908764,
-0.029418492689728737,
-0.017120972275733948,
-0.03396891802549362,
0.038291819393634796,
0.04946311190724373,
-0.01016451045870781,
-0.0313069187104702,
-0.028826937079429626,
0.0545140840113163,
0.012991460971534252,
0.02070443145930767,
0.03196673095226288,
-0.009993869811296463,
-0.004220518749207258,
0.005864359438419342,
0.00417217006906867,
-0.016665929928421974,
0.008480853401124477,
-0.0401574932038784,
-0.01804243214428425,
-0.032103244215250015,
0.04011198878288269,
-0.0939207598567009,
0.011478445492684841,
-0.030624356120824814,
0.01386741828173399,
-0.0296460147947073,
0.015585203655064106,
0.008532045409083366,
-0.03899713605642319,
-0.012991460971534252,
-0.020909199491143227,
-0.05292143300175667,
-0.00030199886532500386,
-0.035197533667087555,
-0.02821263112127781,
0.003099976573139429,
0.011831102892756462,
-0.024026241153478622,
-0.061203207820653915,
-0.008935895748436451,
-0.02677924744784832,
0.02589191496372223,
0.006086192559450865,
-0.0011866653803735971,
0.048826053738594055,
0.0044736359268426895,
0.01616538316011429,
0.05182933434844017,
0.02825813554227352,
-0.004541892092674971,
-0.06748279184103012,
-0.009811852127313614,
-0.009663963690400124,
0.0017149411141872406,
-0.008702686056494713,
-0.037518247961997986,
0.0010210014879703522,
0.011717342771589756,
0.028599416837096214,
-0.03635789081454277,
0.01929379813373089,
-0.008691309951245785,
0.0018087936332449317,
0.007570768240839243,
-0.025869162753224373,
0.046914875507354736,
0.03660816326737404,
0.035311292856931686,
-0.013139350339770317,
-0.01353751216083765,
-0.03624412789940834,
0.04577726870775223,
-0.02177377976477146,
-0.04504920169711113,
0.0024785592686384916,
0.015619331039488316,
-0.0103123988956213,
0.07653813809156418,
0.009641211479902267,
-0.03260378912091255,
0.05123777687549591,
-0.015846852213144302,
-0.05647076666355133,
-0.03128416836261749,
0.028963450342416763,
-0.0006146627711132169,
0.014959519729018211,
-0.017917295917868614,
0.01550557091832161,
0.057517364621162415,
-0.03911089524626732,
-0.027325298637151718,
-0.03738173469901085,
0.07817628979682922,
-0.023639453575015068,
0.0012897609267383814,
-0.05301244184374809,
0.03303607925772667,
-0.023218540474772453,
-0.004954274278134108,
-0.044480398297309875,
-0.02070443145930767,
-0.0036574036348611116,
-0.0006118187448009849,
-0.008395533077418804,
-0.058882489800453186,
0.007297743111848831,
-0.0017803534865379333,
-0.05933753401041031,
0.021978549659252167,
0.007548016496002674,
-0.004795009735971689,
-0.029668767005205154,
0.0063535301014781,
0.049781642854213715,
0.020272139459848404,
0.0000013164680012778263,
-0.034310199320316315,
0.02666548639535904,
0.06247732415795326,
-0.021318737417459488,
-0.04350205510854721,
-0.046391576528549194,
0.016154006123542786,
0.01919141411781311,
-0.03945218026638031,
-0.06634518504142761,
0.012161009013652802,
-0.029600510373711586,
-0.05351299047470093,
0.01583547703921795,
0.002398926764726639,
0.0033075895626097918,
-0.014663741923868656,
0.04759743809700012,
-0.05706232041120529,
0.010096253827214241,
-0.021125344559550285,
-0.02766657993197441,
-0.05314895510673523,
-0.03483349829912186,
-0.0394066758453846,
-0.01020432636141777,
-0.024071743711829185,
-0.0013089580461382866,
-0.016404280439019203,
-0.01454998180270195,
0.01099496241658926,
0.02809887006878853,
0.028235383331775665,
-0.010289646685123444,
-0.005139135289937258,
-0.0022069558035582304,
0.021751027554273605,
-0.0008958647958934307,
-0.05506013333797455,
-0.01062524039298296,
-0.003984465263783932,
0.00353226694278419,
0.008765255101025105,
-0.01945306360721588,
-0.01886150799691677,
-0.02085231989622116,
0.0375637523829937,
0.03189847618341446,
-0.02439027465879917,
-0.03735898435115814,
0.013662649318575859,
-0.012468162924051285,
-0.02475430816411972,
0.033536627888679504,
-0.009538826532661915,
0.02577815391123295,
-0.015710340812802315,
0.04887155815958977,
-0.013196230866014957,
0.056152235716581345,
0.020863695070147514,
-0.004334279336035252,
-0.019134534522891045,
0.009436442516744137,
-0.03922465816140175,
-0.04595928639173508,
0.0018756280187517405,
0.04413911700248718,
0.02243359200656414,
0.009345433674752712,
-0.0276210755109787,
0.01746225357055664,
-0.01576722040772438,
-0.010926706716418266,
-0.03813255578279495,
0.008935895748436451,
0.01925967074930668,
-0.015323554165661335,
-0.027894100174307823,
-0.01036927942186594,
-0.01392429880797863,
0.015141536481678486,
0.018998021259903908,
-0.043001510202884674,
-0.031079398468136787,
0.0153804337605834,
0.03408267721533775,
0.011683214455842972,
0.06589014083147049,
0.003762632142752409,
-0.014117691665887833,
-0.006148760672658682,
0.05392252653837204,
-0.039543185383081436,
-0.03444671258330345,
-0.005702250637114048,
-0.015346306376159191,
-0.061749257147312164,
0.012684307992458344,
-0.03528853878378868,
0.02935023605823517,
0.08190763741731644,
-0.010881202295422554,
0.0030203440692275763,
0.0035607069730758667,
0.05665278434753418,
0.05483261123299599,
-0.048052482306957245,
0.0041124457493424416,
0.017064090818166733,
0.008856263011693954,
0.029259229078888893,
-0.040020979940891266,
-0.03774577006697655,
-0.010090566240251064,
0.022956890985369682,
-0.0221036858856678,
0.010301022790372372,
0.017177851870656013,
0.036039359867572784,
0.030442338436841965,
0.00663793133571744,
0.021523507311940193,
-0.003680155612528324,
-0.021751027554273605,
0.013492007739841938,
0.02950950153172016,
0.024959078058600426,
0.0033900660928338766,
-0.0030288761481642723,
-0.04361581802368164,
0.0047409734688699245,
0.008088379167020321,
-0.019839849323034286,
-0.03669917210936546,
-0.001339531154371798,
0.002842593239620328,
-0.00977772381156683,
-0.019714713096618652,
-0.014322460629045963,
-0.027643827721476555,
0.020351773127913475,
-0.004189234226942062,
-0.035857342183589935,
-0.04077180102467537,
0.027006767690181732,
-0.00784379430115223,
-0.005747754592448473,
-0.055014628916978836,
-0.011029090732336044,
-0.03326360136270523,
0.031079398468136787,
-0.03813255578279495,
-0.038837872445583344,
0.020818190649151802,
0.0036574036348611116,
0.020840942859649658,
-0.049736138433218,
0.035197533667087555,
0.05938303843140602,
-0.006848388351500034,
-0.05223887041211128,
0.008776631206274033,
0.041681885719299316,
0.001980856526643038,
0.011228172108530998,
0.010249830782413483,
-0.02791685238480568,
0.02198992483317852,
-0.017393996939063072,
-0.05005466565489769,
-0.03153444081544876,
-0.03783677890896797,
-0.008071315474808216,
0.036448899656534195,
-0.009538826532661915,
0.0006111077382229269,
0.004052721429616213,
0.023821471258997917,
-0.039656948298215866,
0.04357031360268593,
-0.051510803401470184,
0.042819492518901825,
-0.01449310127645731,
-0.021682770922780037,
-0.029441244900226593,
-0.003975933417677879,
-0.04316077381372452,
0.033604882657527924,
0.01285494863986969,
0.02564164064824581,
0.0799509584903717,
-0.035971105098724365,
0.030214818194508553,
0.009925613179802895,
-0.00751388818025589,
-0.011319180019199848,
0.023218540474772453,
0.026688238605856895,
0.006313713733106852,
0.011182667687535286,
-0.013639897108078003,
-0.012627427466213703,
-0.005269960034638643,
-0.006427474319934845,
0.04354755952954292,
-0.013457879424095154,
0.007161230314522982,
0.0025212194304913282,
-0.003097132546827197,
0.03308158367872238,
0.03089738078415394,
-0.013947050087153912,
0.0033701579086482525,
0.003171076998114586,
0.09874420613050461,
-0.010340839624404907,
0.02070443145930767,
-0.04463966190814972,
-0.026051178574562073,
-0.027325298637151718,
-0.029122715815901756,
0.023616701364517212,
0.002856813371181488,
-0.03064710833132267,
0.010568360798060894,
0.027598323300480843,
-0.0006207062979228795,
0.03631238639354706,
-0.03970245271921158,
0.045504242181777954,
-0.04791596904397011,
0.004749505314975977,
-0.002323560416698456,
0.03214874863624573,
0.026688238605856895,
0.01601749286055565,
0.020090123638510704,
-0.05610673129558563,
0.02287725731730461,
-0.014242827892303467,
-0.03142068162560463,
0.013639897108078003,
-0.005744910798966885,
-0.017393996939063072,
0.0063080256804823875,
-0.02158038690686226,
0.07317082583904266,
0.055014628916978836,
0.036517154425382614,
0.011148539371788502,
-0.020931951701641083,
-0.003665935480967164,
-0.02312753163278103,
0.010022309608757496,
-0.0010892577702179551,
0.04623230919241905,
-0.0070815980434417725,
-0.02320716343820095,
-0.02309340424835682,
-0.0048860181123018265,
0.018793253228068352,
0.03952043503522873,
0.02869042567908764,
0.006768756080418825,
-0.03590284660458565,
-0.036562658846378326,
0.012559170834720135,
-0.01586960442364216,
0.006677747704088688,
-0.012900453060865402,
-0.042409952729940414,
0.0390426404774189,
-0.01291182916611433,
0.007417191751301289,
0.014515853486955166,
-0.005830231122672558,
0.02026076428592205,
0.011245235800743103,
-0.05123777687549591,
0.022035429254174232,
0.03476523980498314,
-0.01675693690776825,
-0.016711432486772537,
0.025687145069241524,
0.02100020833313465,
-0.023593949154019356,
-0.009425066411495209,
-0.044844429939985275,
0.029486749321222305,
-0.03510652482509613,
-0.03355937823653221,
0.0475064292550087,
-0.016483912244439125,
0.01057404838502407,
-0.0012755407951772213,
0.030146561563014984,
-0.010915330611169338,
-0.06420648843050003,
-0.0032108931336551905,
-0.05610673129558563,
-0.034059926867485046,
-0.01826995424926281,
0.015789972618222237,
-0.04891706258058548,
-0.008890391327440739,
0.008429661393165588,
-0.03528853878378868,
-0.005258583929389715,
0.057107824832201004,
0.03669917210936546,
-0.04325178265571594,
-0.03421919047832489,
0.012809444218873978,
-0.017359869554638863,
0.003998685162514448,
0.03899713605642319,
-0.04878054931759834,
0.027825845405459404,
-0.021716900169849396,
0.00706453388556838,
-0.019327927380800247,
0.03196673095226288,
0.04682386666536331,
0.008952959440648556,
0.06575363129377365,
0.010318087413907051,
0.006507106591016054,
0.02018113248050213,
-0.01300283707678318,
0.0010387765942141414,
-0.039725203067064285,
-0.019145909696817398,
-0.023036522790789604,
0.014629614539444447,
0.02618769183754921,
-0.020351773127913475,
-0.023707710206508636,
0.01631327159702778,
0.013935673981904984,
-0.0015329241286963224,
-0.041568126529455185,
0.033127088099718094,
-0.009334057569503784,
0.002280900254845619,
-0.007422879803925753,
0.014766126871109009,
-0.027871347963809967,
0.022558728232979774,
0.007730033248662949,
-0.0010188684100285172,
0.011091658845543861,
0.033604882657527924,
-0.00867424625903368,
0.04416186735033989,
-0.0044679478742182255,
0.009971117600798607,
0.051738325506448746,
-0.014197323471307755,
0.04350205510854721,
-0.030510595068335533,
-0.012945957481861115,
0.0050424388609826565,
-0.008179388009011745,
-0.056698285043239594,
-0.04113583639264107,
-0.06798333674669266,
-0.0063023376278579235,
0.0068256366066634655,
0.021295985206961632,
-0.0043172151781618595,
-0.03731347993016243,
0.01576722040772438,
0.023844223469495773,
0.020784063264727592,
-0.002516953507438302,
-0.04705138877034187,
-0.03569807857275009,
-0.058518458157777786,
-0.03237627074122429,
0.02655172534286976,
-0.004826293792575598,
0.017553262412548065,
0.02297964319586754,
-0.0021273232996463776,
-0.009988181293010712,
-0.0353567972779274,
0.05392252653837204,
-0.029964543879032135,
-0.012866324745118618,
0.040498774498701096,
-0.02309340424835682,
0.04432113096117973,
-0.008964335545897484,
0.002169983694329858,
0.015198417007923126,
-0.0031454807613044977,
-0.018963893875479698,
0.022388087585568428,
0.01929379813373089,
0.02159176394343376,
-0.014766126871109009,
-0.0003668779681902379,
0.005380876827985048,
-0.0003011101216543466,
-0.054423075169324875,
0.010926706716418266,
-0.014094939455389977,
0.008207827806472778,
-0.0074570076540112495,
-0.04479892551898956,
-0.012286145240068436,
0.017780782654881477,
-0.03119315765798092,
-0.027575571089982986,
0.009538826532661915,
0.01775803044438362,
0.007383063435554504,
-0.021125344559550285,
0.025323111563920975,
-0.012695684097707272,
-0.02696126326918602,
-0.0027928228955715895,
-0.00618857704102993,
0.043775081634521484,
0.016347398981451988,
-0.0074513196013867855,
0.02641521394252777,
-0.00042802427196875215,
0.002434476977214217,
-0.046027541160583496,
0.0054150051437318325,
-0.006268209312111139,
0.021489378064870834,
-0.014379341155290604,
0.0046243686228990555,
-0.04732441157102585,
-0.019646456465125084,
0.007411503698676825,
0.0012798068346455693,
0.019066277891397476,
0.02832639217376709,
0.041386108845472336,
0.030123809352517128,
-0.02994179166853428,
0.03194397687911987,
0.017393996939063072,
-0.010420471429824829,
-0.02125048078596592,
-0.0020690211094915867,
0.013981178402900696,
0.0017803534865379333,
-0.03765476122498512,
-0.023366428911685944,
-0.03963419422507286,
-0.005031062755733728,
0.006996277254074812,
0.023195788264274597,
-0.017439501360058784,
0.00920892134308815,
0.037199717015028,
0.049736138433218,
-0.009425066411495209,
-0.013912922702729702,
0.029145468026399612,
0.0033872220665216446,
-0.025982921943068504,
0.009396626614034176,
-0.011603581719100475,
-0.026028426364064217,
-0.023639453575015068,
0.02423100918531418,
-0.017268860712647438,
0.037700265645980835,
-0.02398073673248291,
-0.03196673095226288,
-0.005926927551627159,
0.010027997195720673,
-0.014504477381706238,
0.000025507260943413712,
-0.02228570356965065,
-0.021751027554273605,
-0.006427474319934845,
0.035857342183589935,
0.003537954995408654,
-0.042751237750053406,
0.011341932229697704,
-0.02975977584719658,
-0.01838371343910694,
0.020351773127913475,
-0.013969802297651768,
0.016222262755036354,
-0.00001755290577420965,
0.006541234906762838,
0.033946163952350616,
0.0030175000429153442,
-0.0019623704720288515,
0.011501197703182697,
0.03274030238389969,
0.014777502976357937,
-0.008094067685306072,
-0.018952516838908195,
0.006581051275134087,
-0.03783677890896797,
0.005329684354364872,
-0.01084707397967577,
0.0028895193245261908,
0.0025468156673014164,
0.045663509517908096,
0.04682386666536331,
-0.0016182446852326393,
0.02398073673248291,
0.0009015527903102338,
0.002194157801568508,
-0.026051178574562073,
-0.010659368708729744,
0.012991460971534252,
-0.021113969385623932,
-0.007115725893527269,
-0.03089738078415394,
0.0688934251666069,
-0.008594613522291183,
0.011034779250621796,
-0.010045061819255352,
-0.01305971760302782,
0.015187040902674198,
0.007280678953975439,
-0.015266673639416695,
-0.017928671091794968,
-0.0012172384886071086,
0.011740094982087612,
0.008554797619581223,
-0.027234289795160294,
-0.04491268843412399,
-0.0031511688139289618,
0.03399166837334633,
0.01867949217557907,
0.02903170697391033,
0.011990368366241455,
-0.017302988097071648,
-0.00751388818025589,
-0.019987739622592926,
-0.0233891811221838,
0.015664836391806602,
0.004820605739951134,
0.0035521748941391706,
0.013947050087153912,
-0.02434477023780346,
0.006319401785731316,
0.0036090551875531673,
0.03135242313146591,
0.02103433571755886,
0.031989481300115585,
-0.005008310545235872,
0.04504920169711113,
-0.01683657057583332,
-0.030078304931521416,
-0.035561565309762955,
-0.0014973740326240659,
0.028553912416100502,
0.0007849481771700084,
0.014663741923868656,
-0.03128416836261749,
-0.030192065984010696,
-0.018622610718011856,
-0.0007472650031559169,
-0.024799812585115433,
0.03956593945622444,
0.0070815980434417725,
0.0009363919962197542,
0.003694375744089484,
0.013253110460937023,
-0.045731764286756516,
-0.004851889796555042,
0.02493632584810257,
-0.015209793113172054,
-0.020909199491143227,
0.05091924965381622,
0.00038180904812179506,
-0.009032592177391052,
-0.02404899150133133,
-0.047096893191337585,
-0.013821913860738277,
-0.0015698963543400168,
-0.00539794098585844,
-0.0025183754041790962,
0.011506885290145874,
-0.006199953146278858,
-0.01291182916611433,
-0.010249830782413483,
0.004800697788596153,
0.0047807893715798855,
0.006922333035618067,
0.006091880612075329,
-0.021159473806619644,
0.05005466565489769,
0.002606539987027645,
-0.0017049871385097504,
-0.013116598129272461,
-0.03592560067772865,
0.016631800681352615,
0.006950773298740387,
-0.020795438438653946,
0.001767555484548211,
-0.012354401871562004,
-0.029486749321222305,
0.00706453388556838,
-0.0018585639772936702,
-0.03592560067772865,
-0.026437964290380478,
0.00602362398058176,
-0.016347398981451988,
-0.021421123296022415,
-0.005739222746342421,
-0.01274118758738041,
-0.008776631206274033,
-0.014083563350141048,
0.021944420412182808,
0.0028738772962242365,
0.04570901393890381,
-0.012502290308475494,
-0.00029773282585665584,
0.020238012075424194,
-0.018645362928509712,
-0.03428744524717331,
-0.006427474319934845,
-0.027985109016299248,
-0.01948719285428524,
-0.018395090475678444,
0.009772036224603653,
0.012638803571462631,
-0.00023943053383845836,
-0.028826937079429626,
0.012252017855644226,
-0.014367965050041676,
0.004712533205747604,
-0.024981830269098282,
0.0009427910554222763,
-0.03524303436279297,
-0.01059111300855875,
-0.008014434948563576,
0.0035635509993880987,
-0.021500755101442337,
0.012581923045217991,
-0.017075467854738235,
0.03494725748896599,
0.042045921087265015,
-0.1090281680226326,
-0.028781434521079063,
-0.016882074996829033,
0.0023775966838002205,
0.006171512883156538,
0.0005680920439772308,
0.006057752296328545,
-0.024481283500790596,
0.0038308885414153337,
-0.0268930085003376,
-0.021739652380347252,
0.010522856377065182,
0.019020773470401764,
0.010158821940422058,
-0.005107851233333349,
-0.03123866207897663,
-0.02312753163278103,
-0.009061031974852085,
-0.012627427466213703,
0.020124251022934914,
0.006393346004188061,
0.004968494642525911,
0.017041338607668877,
0.029828030616044998,
0.01057404838502407,
0.019771592691540718,
-0.03790503367781639,
-0.001768977497704327,
-0.05360399931669235,
0.001426273607648909,
0.021534882485866547,
0.016768313944339752,
-0.02743905782699585,
0.03988447040319443,
-0.0060406881384551525,
-0.05506013333797455,
0.04325178265571594,
-0.024708803743124008,
-0.00994836539030075,
-0.00669481186196208,
0.012274769134819508,
-0.004075473640114069,
0.020340396091341972,
-0.04277398809790611,
-0.02511834166944027,
0.005105007439851761,
-0.08504743129014969,
-0.03628963232040405,
-0.013309990987181664,
-0.02106846496462822,
0.026756495237350464,
-0.002401770791038871,
-0.01853160373866558,
0.01863398775458336,
0.005326840560883284,
-0.01731436513364315,
-0.012274769134819508,
0.01779215969145298,
-0.015642084181308746,
0.016222262755036354,
0.008742502890527248,
0.04648258537054062,
0.019168661907315254,
-0.01756463758647442,
0.013241734355688095,
-0.010289646685123444,
-0.04539048299193382,
0.012468162924051285,
-0.028462903574109077,
0.025869162753224373,
-0.00266057625412941,
0.016563544049859047,
-0.013799161650240421,
0.030556099489331245,
-0.015892356634140015,
0.014299708418548107,
-0.007030405569821596,
-0.012502290308475494,
0.00909516029059887,
0.02065892703831196,
-0.00015242144581861794,
-0.019020773470401764,
0.011398812755942345,
0.014470349065959454,
-0.00803149864077568,
0.013799161650240421,
-0.013264486566185951,
0.02416275255382061,
-0.021386994048953056,
-0.007098661735653877,
-0.018554355949163437,
-0.004752349574118853,
-0.012195137329399586,
0.0005232988041825593,
-0.0100393733009696,
-0.017928671091794968,
-0.026619981974363327,
-0.003105664625763893,
-0.007257926743477583,
-0.02128461003303528,
0.0618857704102993,
-0.0353567972779274,
-0.0043570310808718204,
-0.019316550344228745,
-0.032945070415735245,
-0.020090123638510704,
0.027871347963809967,
0.009470570832490921,
0.026938511058688164,
-0.0416136309504509,
0.0420004166662693,
0.005605553742498159,
0.025209350511431694,
-0.03988447040319443,
0.005887111648917198,
0.010943770408630371,
-0.0006246168632060289,
-0.009959741495549679,
0.02328679710626602,
0.0011383170494809747,
0.0633419081568718,
0.02357119880616665,
-0.005591333843767643,
-0.01830408163368702,
0.004800697788596153,
0.02202405408024788,
0.00616013677790761,
0.030783619731664658,
0.012832196429371834,
-0.010909642092883587,
0.0197033379226923,
0.0007394439307972789,
-0.009453506208956242,
-0.002278056228533387,
0.014481725171208382,
0.016290519386529922,
-0.00038927458808757365,
0.011990368366241455,
-0.010130382142961025,
0.03358213230967522,
0.0009705201955512166,
-0.006677747704088688,
-0.022513223811984062,
-0.02844015136361122,
0.011523949913680553,
0.003495294600725174,
-0.0331498421728611,
0.00512775918468833,
-0.0024558070581406355,
0.004226206336170435,
-0.04498094320297241,
0.038360077887773514,
0.06579913198947906,
0.027757588773965836,
0.03540230169892311,
0.022956890985369682,
0.015892356634140015,
-0.007041781675070524,
-0.02718878537416458,
0.01460686232894659,
-0.007411503698676825,
0.06184026598930359,
-0.05064622312784195,
-0.0029492436442524195,
0.034014422446489334,
-0.005562893580645323,
-0.016381528228521347,
0.004140886012464762,
0.00852635782212019,
0.011796974577009678,
0.016586296260356903,
-0.06320539116859436,
0.05169282108545303,
0.028576664626598358,
-0.03160269558429718,
0.004974182695150375,
0.038769613951444626,
0.017541885375976562,
0.014185947366058826,
0.03421919047832489,
-0.02423100918531418,
-0.005173263605684042,
0.005412160884588957,
0.036448899656534195,
0.00794049073010683,
-0.02659722976386547,
0.03176196292042732,
-0.031511686742305756,
0.009237361140549183,
-0.0030317201744765043,
-0.004175014328211546,
-0.045800019055604935,
0.03016931377351284,
0.05264841020107269,
0.024731555953621864,
-0.009083784185349941,
-0.061976779252290726,
0.006114632822573185,
-0.04277398809790611,
-0.031625449657440186,
-0.04409361258149147,
0.03715421259403229,
0.0311249028891325,
-0.014333836734294891,
-0.029714271426200867,
-0.0030175000429153442,
0.02814437448978424,
0.0001329577062278986,
-0.0221036858856678,
0.051510803401470184,
0.03349112346768379,
0.045026447623968124,
-0.029327483847737312,
-0.007383063435554504,
0.029737023636698723,
0.005227299872785807,
-0.0018159036990255117,
0.04195491224527359,
-0.010448912158608437,
-0.0028041990008205175,
-0.0276210755109787,
-0.018463347107172012,
0.01808793656527996,
0.01222926564514637,
0.006734627764672041,
-0.010374967008829117,
0.012445410713553429,
0.014720622450113297,
-0.020840942859649658,
0.020545165985822678,
-0.01927104778587818,
0.041681885719299316,
0.011194043792784214,
0.004749505314975977,
-0.002415990922600031,
0.006649307440966368,
-0.0007273568771779537,
-0.021057087928056717,
0.016552168875932693,
-0.0134465042501688,
-0.00418070238083601,
-0.011808350682258606,
-0.008668558672070503,
-0.02714328095316887,
-0.028371894732117653,
-0.006928021088242531,
0.007758473511785269,
-0.015698963776230812,
0.00017552905774209648,
-0.011171291582286358,
-0.00532115250825882,
0.0006889626965858042,
0.0006498574512079358,
0.028121622279286385,
0.058472953736782074,
0.019032150506973267,
-0.0006665660766884685,
0.017029963433742523,
0.005852983333170414,
0.014470349065959454,
0.018019679933786392,
-0.030692612752318382,
-0.0015926484484225512,
-0.013423752039670944,
-0.011415877379477024,
-0.0219102930277586,
0.0047352854162454605,
-0.012286145240068436,
-0.012775315903127193,
0.014788879081606865,
0.048234496265649796,
0.018998021259903908,
-0.04837100952863693,
0.002771492814645171,
0.018963893875479698,
-0.013696776703000069,
0.019828474149107933,
0.0032933696638792753,
-0.042705733329057693,
-0.018508851528167725,
0.0038280445151031017,
-0.029623262584209442,
-0.036812931299209595,
0.032763056457042694,
0.02037452533841133,
0.023935232311487198,
-0.0026207598857581615,
0.017393996939063072,
0.008486540988087654,
-0.008748190477490425,
-0.02184203639626503,
-0.021978549659252167,
-0.030601603910326958,
0.00465849693864584,
-0.017621517181396484,
-0.010750377550721169,
-0.03676742687821388,
0.002482825191691518,
-0.0032251132652163506,
-0.03185297176241875,
0.00794049073010683,
0.012866324745118618,
0.005949679762125015,
-0.03617587313055992,
0.02202405408024788,
-0.021352866664528847,
-0.005122071132063866,
-0.05028218775987625,
0.04736991599202156,
-0.013571640476584435,
-0.02832639217376709,
0.006069128401577473,
0.025027332827448845,
-0.012217889539897442,
0.026915758848190308,
0.036335136741399765,
-0.02903170697391033,
0.0005634705303236842,
-0.02169414795935154,
0.0021358553785830736,
-0.0027060804422944784,
-0.0044793239794671535,
0.0068711405619978905,
-0.0290999636054039,
-0.02375321462750435,
0.029782526195049286,
0.0049969349056482315,
-0.021716900169849396,
-0.00399584136903286,
-0.023457437753677368,
0.009021216072142124,
-0.006126008927822113,
0.010727625340223312,
0.016347398981451988,
0.01386741828173399,
0.0028880974277853966,
-0.01771252602338791,
-0.0198967307806015,
0.002017828868702054,
-0.01005643792450428,
-0.018463347107172012,
0.016199510544538498,
0.012627427466213703,
0.0036090551875531673,
0.0022894323337823153,
-0.0007764161564409733,
-0.024799812585115433,
-0.04011198878288269,
-0.021079840138554573,
-0.011137163266539574,
0.0515563078224659,
-0.05569719523191452,
-0.04063528776168823,
0.04741542041301727,
0.003768320195376873,
0.020021867007017136,
0.01583547703921795,
0.03886062279343605,
-0.0034668545704334974,
0.0013288661139085889,
-0.01353751216083765,
0.008759566582739353,
0.03897438570857048,
0.0077072810381650925,
0.012081376276910305,
0.040430519729852676,
-0.029418492689728737,
-0.03815530613064766,
0.027120528742671013,
0.017553262412548065,
0.025391368195414543,
-0.02328679710626602,
0.002142965327948332,
0.007104349788278341,
0.007479759864509106,
0.011023403145372868,
0.03524303436279297,
0.02618769183754921,
-0.026528973132371902,
0.058472953736782074,
0.02297964319586754,
-0.02073855884373188,
-0.004140886012464762,
-0.030078304931521416,
-0.012058624066412449,
-0.02809887006878853,
-0.022740745916962624,
-0.026642734184861183,
-0.010403407737612724,
-0.022342583164572716,
-0.01772390305995941,
-0.015118785202503204,
0.007997370325028896,
0.0038621725980192423,
-0.025368615984916687,
-0.01897526904940605,
-0.013856042176485062,
0.001838655793108046,
0.014720622450113297,
-0.019316550344228745,
-0.016415655612945557,
-0.01285494863986969,
-0.005841607227921486,
-0.01756463758647442,
0.013674025423824787,
0.017746655270457268,
-0.012445410713553429,
-0.0012215045280754566,
0.022717993706464767,
-0.002431632950901985,
0.01088688988238573,
0.004237582441419363,
-0.05128328129649162,
0.012513666413724422,
-0.01709822006523609,
-0.00037754300865344703,
-0.005926927551627159,
-0.022240199148654938,
-0.003899144707247615,
-0.002687594387680292,
-0.010960834100842476,
-0.005287024192512035,
-0.020943328738212585,
0.002943555824458599,
-0.03558431938290596,
-0.0022894323337823153,
0.010921018198132515,
0.008003058843314648,
-0.06971249729394913,
0.0039503369480371475,
-0.001679391018114984,
-0.009220297448337078,
0.022774873301386833,
-0.006364906206727028,
-0.03171645849943161,
0.02434477023780346,
-0.024413026869297028,
0.03660816326737404,
-0.0008091223426163197,
0.008742502890527248,
0.02327542006969452,
-0.015346306376159191,
0.04759743809700012,
0.013503383845090866,
-0.0016395747661590576,
-0.03806430101394653,
-0.0006729650776833296,
0.018736371770501137,
0.019066277891397476,
0.021489378064870834,
0.020602045580744743,
0.02202405408024788,
-0.012081376276910305,
-0.029896287247538567,
-0.03082912415266037,
0.0007170473108999431,
-0.03870135918259621,
-0.010687809437513351,
-0.010130382142961025,
0.011154227890074253,
-0.020283516496419907,
-0.02011287584900856,
-0.001922554220072925,
0.03219425305724144,
-0.014800255186855793,
-0.014982271939516068,
-0.0114215649664402,
-0.014185947366058826,
-0.04093106836080551,
-0.02287725731730461,
0.014561357907950878,
0.005645370110869408,
0.022900009527802467,
-0.008105442859232426,
0.047460924834012985,
-0.004214830696582794,
0.029441244900226593,
0.01609712652862072,
0.0017974176444113255,
-0.006967836990952492,
-0.02718878537416458,
-0.007274990901350975,
-0.013321367092430592,
-0.009527450427412987,
-0.006006560288369656,
0.01823582500219345,
0.008293148130178452,
-0.00532115250825882,
0.0068256366066634655,
-0.0006111077382229269,
0.004285930655896664,
-0.016006117686629295,
-0.014982271939516068,
-0.014311084523797035,
0.018838755786418915,
0.01775803044438362,
0.003850796492770314,
-0.03433294966816902,
-0.022672489285469055,
-0.036039359867572784,
0.005406472831964493,
-0.02110259234905243,
0.004903082270175219,
-0.02464054711163044,
-0.018622610718011856,
-0.023457437753677368,
-0.05091924965381622,
-0.02825813554227352,
0.021045712754130363,
0.02916822023689747,
-0.010016621090471745,
0.0004504208918660879,
-0.01775803044438362,
0.01782628707587719,
0.029372988268733025,
-0.021637268364429474,
-0.0109551465138793,
0.023775966838002205,
0.0023619546554982662,
-0.016290519386529922,
0.00331896566785872,
0.009789099916815758,
0.013218982145190239,
-0.0313069187104702,
0.007781225722283125,
-0.028280887752771378,
0.0134465042501688,
0.01929379813373089,
-0.04152262210845947,
0.031329672783613205,
0.029714271426200867,
-0.0408855639398098,
0.013651273213326931,
-0.025982921943068504,
-0.006746003869920969,
0.04504920169711113,
-0.012001744471490383,
-0.0038223564624786377,
-0.009811852127313614,
-0.0071327900514006615,
-0.027097776532173157,
0.016518039628863335,
0.037927787750959396,
0.0036574036348611116,
0.0057107824832201,
0.03790503367781639,
0.035857342183589935,
-0.025732649490237236,
-0.01296870969235897,
0.011057531461119652,
0.003671623533591628,
0.004812073893845081,
0.01985122635960579,
0.003324653720483184,
-0.007303431164473295,
-0.04188665747642517,
-0.007627648767083883,
-0.007502512075006962,
-0.00878800731152296,
0.004962806589901447,
0.007832418195903301,
0.022297078743577003,
0.025687145069241524,
0.02873593010008335,
-0.0013985445257276297,
-0.0018045275937765837,
-0.004940054379403591,
-0.02803061343729496,
-0.022331207990646362,
-0.0011056108633056283,
-0.026756495237350464,
0.011250924319028854,
-0.027689332142472267,
-0.02659722976386547,
-0.02202405408024788,
0.019589576870203018,
-0.014197323471307755,
-0.017325740307569504,
0.00402428163215518,
-0.014094939455389977,
-0.01779215969145298,
0.029008954763412476,
-0.00316254491917789,
0.036448899656534195,
0.006091880612075329,
-0.030874628573656082,
-0.05069172754883766,
-0.002073287032544613,
-0.013321367092430592,
-0.0014874199405312538,
-0.05792690068483353,
-0.011000650934875011,
-0.006746003869920969,
-0.008611678145825863,
-0.01966920867562294,
0.0008745346567593515,
-0.0043627191334962845,
-0.012672931887209415,
-0.026506220921874046,
-0.0191572867333889,
-0.021864788606762886,
0.010602488182485104,
-0.001754757366143167,
-0.01434521283954382,
0.0030601604375988245,
-0.01119973137974739,
0.007479759864509106,
0.00030662037897855043,
-0.02946399711072445,
0.013571640476584435,
-0.03774577006697655,
-0.003159700892865658,
-0.018281329423189163,
0.013150726445019245,
-0.0034042862243950367,
0.020021867007017136,
-0.027120528742671013,
0.01606299728155136,
0.003591991262510419,
0.006222705356776714,
0.0013224671129137278,
0.024071743711829185,
-0.03189847618341446,
-0.00030324311228469014,
0.020067371428012848,
-0.0011425830889493227,
-0.01775803044438362,
-0.011233859695494175,
0.017962800338864326,
-0.02103433571755886,
-0.009476258419454098,
0.018213072791695595,
-0.011358996853232384,
-0.032103244215250015,
0.020090123638510704,
-0.006091880612075329,
0.009675339795649052,
0.0063023376278579235,
-0.02784859761595726,
0.013366871513426304,
-0.03679018095135689,
0.014777502976357937,
0.02589191496372223,
0.0109551465138793,
-0.02987353503704071,
0.051920339465141296,
0.004806385841220617,
0.0005293423309922218,
0.005523077677935362,
-0.02737080305814743,
-0.013662649318575859,
0.0010672167409211397,
0.013503383845090866,
-0.015096032992005348,
0.01960095204412937,
0.026528973132371902,
-0.0013046920066699386,
0.023775966838002205,
0.006677747704088688,
-0.0011959084076806903,
0.0114215649664402,
-0.016108501702547073,
-0.018622610718011856,
0.030010048300027847,
0.007218110375106335,
0.014185947366058826,
0.04104482755064964,
0.01296870969235897,
0.0008837777422741055,
-0.030123809352517128,
-0.006660683546215296,
-0.015846852213144302,
-0.000837562489323318,
0.014527229592204094,
0.0905989482998848,
-0.014800255186855793,
0.0006797196110710502,
0.007422879803925753,
0.0033786899875849485,
0.0013686823658645153,
0.013799161650240421,
0.0011127209290862083,
-0.019475815817713737,
-0.004940054379403591,
0.013048341497778893,
0.015357681550085545,
0.035971105098724365,
0.002263836096972227,
0.01338962372392416,
-0.0250500850379467,
0.007371687330305576,
0.039065390825271606,
-0.0010295334504917264,
-0.004388315603137016,
0.01930517517030239,
0.013014213182032108,
-0.007803977467119694,
0.013412375934422016,
-0.026392461732029915,
0.0019652144983410835,
0.0038081363309174776,
0.008441037498414516,
-0.029259229078888893,
-0.01738261990249157,
0.037882283329963684,
-0.023366428911685944,
0.005926927551627159,
-0.03064710833132267,
0.009931300766766071,
-0.009123601019382477,
-0.004925834480673075,
-0.02375321462750435,
0.020215259864926338,
-0.007314807269722223,
0.0012407016474753618,
0.0037114399019628763,
-0.010812945663928986,
0.025368615984916687,
0.02143249846994877,
0.013150726445019245,
-0.021682770922780037,
-0.0023719086311757565,
0.005909863393753767,
-0.046277813613414764,
-0.0017831975128501654,
-0.0021785155404359102,
0.018645362928509712,
-0.008111131377518177,
-0.020488284528255463,
0.011262300424277782,
0.01650666445493698,
0.009368185885250568,
-0.023366428911685944,
-0.0475064292550087,
-0.044730670750141144,
0.01749638095498085,
0.025960169732570648,
0.024663299322128296,
0.0026975483633577824
] | 2024-07-11 | 62 | 38986621 | [
"CD5.CART cells",
"target cells",
"a prominent pan-T cell antigen",
"lymphocyte antigens",
"Chimeric antigen receptor T cells",
"CD5",
"T cell malignancies results",
"T cell fratricide",
"similar internalization",
"rapid internalization",
"T cells",
"additional engineering",
"sustained activity",
"complete loss",
"healthy and malignant T cells",
"full ablation",
"a chimeric antigen receptor",
"the CD5 protein",
"CAR",
"CART",
"patients",
"exposure",
"cytotoxicity",
"self-damage",
"self-targeting",
"the expression",
"this protection",
"We",
"them"
] | [
"CAR",
"CD5",
"T cell fratricide",
"T cell malignancies",
"chimeric antigen receptor",
"clinical trials",
"fratricide",
"off-tumor toxicity"
] | 0 | 10.1016/j.xcrm.2024.101628
10.1182/blood.2021014498
10.3389/fimmu.2020.01128
10.1073/pnas.2216352120
10.1182/blood-2009-06
10.1007/978-1-0716-0146-4_8 | [
"Ma",
"Woods",
"Burkhardt",
"Crooks",
"van Leeuwen",
"Shmidt",
"Couturier",
"Chaumette",
"Popat",
"Hill",
"Rouce",
"Thakkar",
"Orozco",
"Carisey",
"Brenner",
"Mamonkin"
] | [
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA; Graduate Program in Immunology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA; Graduate Program in Immunology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA; Graduate Program in Immunology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.",
"William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA; Graduate Program in Immunology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA; Graduate Program in Immunology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: [email protected]."
] | [
"38986621",
"29972754",
"30891427",
"32661440",
"36086817",
"37171449",
"35294525",
"30918399",
"1978939",
"12115665",
"10082557",
"17513730",
"21622855",
"26056165",
"20185133",
"38145560",
"29997304",
"30826931",
"28539325",
"31466926",
"23297870",
"20978348",
"36044667",
"32437331",
"35500125",
"32034142",
"29089311",
"28506593",
"25415440",
"34035409",
"29296885",
"29079655",
"1372189",
"3488778",
"1878584",
"1747958",
"20628903",
"12023358",
"20085752",
"23927424",
"11123317",
"3264717",
"8621884",
"2785456",
"32582204",
"30275568",
"29155426",
"31110217",
"29812997",
"30896447",
"36598945",
"34429382",
"25520398",
"28676342",
"20089966",
"26516065",
"30104252",
"35362043",
"36323436",
"31707671",
"32731885",
"34594043"
] | [] | 8.321249 | 5.215681 |
38985855 | 741 | Preclinical studies show that Co-STARs combine the advantages of chimeric antigen and T cell receptors for the treatment of tumors with low antigen densities. | Two types of engineered T cells have been successfully used to treat patients with cancer, one with an antigen recognition domain derived from antibodies [chimeric antigen receptors (CARs)] and the other derived from T cell receptors (TCRs). CARs use high-affinity antigen-binding domains and costimulatory domains to induce T cell activation but can only react against target cells with relatively high amounts of antigen. TCRs have a much lower affinity for their antigens but can react against target cells displaying only a few antigen molecules. Here, we describe a new type of receptor, called a Co-STAR (for costimulatory synthetic TCR and antigen receptor), that combines aspects of both CARs and TCRs. In Co-STARs, the antigen-recognizing components of TCRs are replaced by high-affinity antibody fragments, and costimulation is provided by two modules that drive NF-κB signaling (MyD88 and CD40). Using a TCR-mimic antibody fragment that targets a recurrent p53 neoantigen presented in a common human leukocyte antigen (HLA) allele, we demonstrate that T cells equipped with Co-STARs can kill cancer cells bearing low densities of antigen better than T cells engineered with conventional CARs and patient-derived TCRs in vitro. In mouse models, we show that Co-STARs mediate more robust T cell expansion and more durable tumor regressions than TCRs similarly modified with MyD88 and CD40 costimulation. Our data suggest that Co-STARs may have utility for other peptide-HLA antigens in cancer and other targets where antigen density may limit the efficacy of engineered T cells. | [
0.01507845800369978,
0.0034285399597138166,
-0.02600470557808876,
0.04733520746231079,
-0.004006883595138788,
0.01415310800075531,
0.005679631605744362,
0.008796756155788898,
0.008879800327122211,
-0.00032921103411354125,
-0.01818668469786644,
-0.0233710166066885,
-0.031936436891555786,
0.010777954012155533,
0.015090322121977806,
-0.04508114978671074,
0.006186794489622116,
-0.018791722133755684,
0.008357807993888855,
0.0233710166066885,
0.028068946674466133,
0.02120000310242176,
-0.009134864434599876,
0.004896643105894327,
-0.012314272113144398,
0.006074091885238886,
0.049921441823244095,
0.019550982862710953,
-0.02280157059431076,
-0.044606611132621765,
0.018518861383199692,
-0.02195926569402218,
0.0027790155727416277,
-0.02426077611744404,
-0.002746391110122204,
0.008245104923844337,
0.011382990516722202,
0.0015644938684999943,
-0.0010580724338069558,
0.014936096966266632,
0.019693344831466675,
0.021425409242510796,
0.020666148513555527,
0.08081389218568802,
-0.0621170774102211,
-0.007479911670088768,
0.015778401866555214,
-0.0043331291526556015,
0.007230779156088829,
-0.006779967807233334,
-0.014817462302744389,
-0.02318120189011097,
-0.02491326630115509,
0.042233917862176895,
-0.07360091060400009,
0.03207879886031151,
-0.039030786603689194,
0.021888084709644318,
-0.009556017816066742,
0.019764525815844536,
-0.007580751087516546,
0.01415310800075531,
0.005077560897916555,
-0.04197292402386665,
-0.050111256539821625,
0.014698827639222145,
-0.04728775471448898,
0.00542753329500556,
0.0013865419896319509,
0.060551103204488754,
0.03146189823746681,
-0.02299138717353344,
-0.0003777770616579801,
0.004810633137822151,
0.026336882263422012,
-0.007307891733944416,
-0.024320093914866447,
0.06259161978960037,
0.03169916570186615,
0.011347400024533272,
0.03988495469093323,
0.01563604176044464,
0.02299138717353344,
-0.036586910486221313,
-0.007005373481661081,
-0.022267716005444527,
0.015541133470833302,
-0.03336004912853241,
-0.04142720252275467,
-0.008749302476644516,
0.013820931315422058,
0.02434382028877735,
0.0009920818265527487,
0.04137974977493286,
-0.0035145501606166363,
0.0333125963807106,
-0.06847589462995529,
-0.019764525815844536,
0.04935199394822121,
0.013429436832666397,
0.03862742707133293,
-0.02396419085562229,
-0.022564301267266273,
0.016763068735599518,
0.041783109307289124,
-0.017878234386444092,
-0.019574709236621857,
0.023857418447732925,
0.032814331352710724,
0.01645462028682232,
0.07673285901546478,
0.001950056292116642,
-0.01447342149913311,
0.04534214735031128,
-0.012468497268855572,
-0.07360091060400009,
-0.041593290865421295,
0.024367548525333405,
-0.010166985914111137,
0.006364746484905481,
0.010617797262966633,
0.001982680754736066,
0.058130957186222076,
-0.025316623970866203,
0.004935199394822121,
-0.013144713826477528,
0.06577102839946747,
-0.0345938503742218,
-0.01907644420862198,
-0.05025361850857735,
0.031722892075777054,
-0.0006365487934090197,
0.014663237147033215,
0.03309905529022217,
-0.058178409934043884,
-0.013987019658088684,
0.0010209990432485938,
-0.010772022418677807,
-0.03181780129671097,
0.036919087171554565,
-0.012575267814099789,
-0.058558039367198944,
-0.008126470260322094,
0.007159598171710968,
-0.028472304344177246,
-0.04939945042133331,
-0.04579295590519905,
0.0075985463336110115,
-0.02728595957159996,
0.0454607792198658,
-0.027523228898644447,
0.02837739698588848,
0.038318976759910583,
-0.0008689984679222107,
-0.04247118905186653,
-0.06392032653093338,
-0.015980081632733345,
0.03400067612528801,
-0.013298938982188702,
-0.0563751645386219,
-0.01799686998128891,
0.0201797466725111,
-0.027309685945510864,
0.0013465028023347259,
0.024035369977355003,
0.002259989269077778,
0.006655401550233364,
0.023786237463355064,
-0.06899788975715637,
0.009763628244400024,
-0.008885731920599937,
-0.04451170191168785,
-0.07763448357582092,
0.006406268570572138,
-0.04949435591697693,
-0.023726921528577805,
0.01581399329006672,
0.011792279779911041,
-0.031533077359199524,
-0.029492562636733055,
-0.007859542965888977,
0.006418132223188877,
0.03411931172013283,
-0.021662678569555283,
0.009063683450222015,
-0.00395349832251668,
-0.025696255266666412,
0.016086852177977562,
-0.005006380379199982,
-0.027499500662088394,
0.00193374406080693,
0.018554452806711197,
0.034926027059555054,
-0.02172199636697769,
-0.010914383456110954,
-0.029041750356554985,
0.023904873058199883,
0.013785340823233128,
0.02607588656246662,
-0.022374486550688744,
0.04567432403564453,
-0.03796307370066643,
-0.009935648180544376,
0.013204031623899937,
-0.02203044667840004,
-0.019242532551288605,
-0.007557024247944355,
0.004724623169749975,
-0.018091777339577675,
-0.0026752103585749865,
0.05200941115617752,
-0.030465366318821907,
-0.02702496387064457,
0.017142700031399727,
-0.03336004912853241,
-0.025957250967621803,
-0.008695916272699833,
-0.006388473324477673,
0.018471408635377884,
0.0007711249054409564,
-0.030370458960533142,
0.009977170266211033,
-0.011430444195866585,
-0.007462116423994303,
-0.058368224650621414,
-0.013939565978944302,
-0.015268273651599884,
-0.013809068128466606,
-0.0007544419495388865,
-0.019823841750621796,
-0.055615901947021484,
0.018008733168244362,
0.03475993871688843,
-0.04603022709488869,
-0.05599553510546684,
0.031983889639377594,
-0.01620548777282238,
-0.014781871810555458,
0.0665777400135994,
-0.05604298785328865,
-0.01940862089395523,
0.013168441131711006,
0.02548271231353283,
-0.017213881015777588,
-0.054144833236932755,
0.011501625180244446,
-0.0047483500093221664,
-0.0569920651614666,
-0.003736990038305521,
-0.0198594331741333,
0.0428982712328434,
0.025411533191800117,
-0.0008556520915590227,
0.015991944819688797,
0.03124835528433323,
0.058558039367198944,
0.04237627983093262,
-0.013975156471133232,
0.03433285281062126,
-0.0035560722462832928,
0.014176835305988789,
0.011661781929433346,
-0.027641862630844116,
-0.019313713535666466,
-0.044986240565776825,
0.0284960325807333,
0.028424851596355438,
0.009508563205599785,
0.01546995248645544,
0.005881310440599918,
0.04130857065320015,
0.02645551599562168,
0.03630219027400017,
-0.01997806690633297,
-0.05903257802128792,
-0.006198658142238855,
-0.00024783509434200823,
0.04605395346879959,
0.019895022734999657,
0.013761614449322224,
0.0024379410315304995,
-0.01239731628447771,
0.002446838654577732,
0.004837325774133205,
-0.035946283489465714,
-0.012693902477622032,
-0.001348727149888873,
-0.005652938969433308,
-0.012895581312477589,
-0.04935199394822121,
0.03760717064142227,
-0.019883159548044205,
-0.00023096674703992903,
-0.00973396934568882,
-0.026479244232177734,
0.005003414582461119,
-0.023026976734399796,
-0.007865474559366703,
-0.030536547303199768,
-0.002380106830969453,
-0.03248215466737747,
-0.013144713826477528,
0.0023326529189944267,
-0.029089204967021942,
0.003140851156786084,
0.01065931934863329,
0.008464579470455647,
-0.0416170209646225,
0.05006380379199982,
0.02163895219564438,
0.013120987452566624,
-0.030584001913666725,
0.028709573671221733,
0.005335591267794371,
0.002139871707186103,
-0.0010877309832721949,
0.01162025984376669,
-0.052673764526844025,
0.036800455302000046,
-0.05471428111195564,
-0.029255293309688568,
-0.009585675783455372,
-0.024628544226288795,
0.004119586665183306,
0.03701399639248848,
-0.03516329824924469,
0.020156018435955048,
0.010012760758399963,
0.0029851433355361223,
-0.017249472439289093,
0.021876221522688866,
-0.028092674911022186,
0.059554573148489,
0.034285400062799454,
0.0006361780688166618,
-0.012705766595900059,
-0.04337280988693237,
-0.02740459330379963,
-0.017498604953289032,
0.032363519072532654,
-0.029445108026266098,
0.02375064790248871,
-0.07640068233013153,
0.026787694543600082,
0.050490885972976685,
0.027807950973510742,
0.013524345122277737,
-0.011792279779911041,
-0.001994544407352805,
-0.009016229771077633,
0.042305100709199905,
0.023015113547444344,
0.017985006794333458,
-0.0016653332859277725,
-0.014995413832366467,
0.018661223351955414,
0.01411751750856638,
-0.04028831049799919,
0.03165171295404434,
-0.00009954184497473761,
0.0038793515413999557,
0.012587131932377815,
-0.048830002546310425,
0.020072974264621735,
0.022457530722022057,
0.05647007003426552,
-0.026858873665332794,
0.035448018461465836,
0.016098715364933014,
-0.06942497193813324,
-0.011323672719299793,
0.0028353671077638865,
0.0050627319142222404,
0.03402440622448921,
0.0034048131201416254,
0.026526696979999542,
0.04833173751831055,
-0.005866480991244316,
0.02267107367515564,
-0.02165081538259983,
0.054524462670087814,
-0.04724029824137688,
-0.011863460764288902,
-0.010457640513777733,
0.02010856568813324,
0.017308788374066353,
0.0448438823223114,
0.0005738948821090162,
-0.06747936457395554,
0.0480232872068882,
-0.011228765361011028,
-0.01888662949204445,
-0.02439127489924431,
0.016869841143488884,
-0.028519758954644203,
0.05224667862057686,
-0.011549078859388828,
0.06766917556524277,
0.04299318045377731,
0.0320076160132885,
-0.012527814134955406,
-0.011988027021288872,
-0.024675996974110603,
-0.04266100376844406,
0.04389480501413345,
-0.026431789621710777,
0.033454958349466324,
0.03898333013057709,
0.053385570645332336,
-0.0009149693651124835,
0.023454060778021812,
0.014805599115788937,
0.02203044667840004,
0.017985006794333458,
-0.03226861357688904,
-0.012990489602088928,
-0.02887566201388836,
0.0390545129776001,
-0.00870778039097786,
0.02171013318002224,
-0.01613430678844452,
-0.034617576748132706,
0.035187024623155594,
-0.031082266941666603,
-0.003621321404352784,
-0.01716642640531063,
-0.006744377315044403,
0.03772580251097679,
-0.012011753395199776,
-0.04173565283417702,
0.01092031504958868,
0.06695736944675446,
-0.010457640513777733,
-0.030536547303199768,
-0.008939117193222046,
0.04576922953128815,
-0.013726023957133293,
-0.003123055910691619,
0.005047902464866638,
0.03471248596906662,
-0.039291780441999435,
0.013405710458755493,
-0.010386459529399872,
-0.057798780500888824,
-0.005519474856555462,
0.027760498225688934,
0.008802687749266624,
-0.016727479174733162,
-0.011893118731677532,
-0.0047424184158444405,
-0.005836822558194399,
-0.036159828305244446,
-0.02061869390308857,
0.04209155589342117,
-0.031865254044532776,
-0.025506440550088882,
0.043965984135866165,
-0.02203044667840004,
-0.001690543140284717,
0.029753558337688446,
0.044867608696222305,
-0.042945727705955505,
0.005504645872861147,
-0.035115841776132584,
-0.022813433781266212,
0.01863749697804451,
0.03513956815004349,
-0.024094687774777412,
0.0021309740841388702,
-0.04054930806159973,
0.010297483764588833,
-0.024747177958488464,
0.003846727078780532,
-0.007687522564083338,
-0.011098267510533333,
-0.007723112590610981,
0.06192726269364357,
-0.014639509841799736,
0.010273756459355354,
-0.015529269352555275,
0.008826414123177528,
-0.01328707579523325,
-0.023928599432110786,
0.02093900740146637,
0.021674541756510735,
0.04503369703888893,
-0.013975156471133232,
-0.006127477157860994,
-0.019052717834711075,
0.025980979204177856,
0.017510468140244484,
-0.028709573671221733,
0.0691402480006218,
-0.01101522333920002,
0.024936994537711143,
-0.03222115710377693,
-0.005231786053627729,
0.005510577466338873,
-0.03772580251097679,
0.020203473046422005,
0.027784224599599838,
0.015802130103111267,
-0.01033900585025549,
0.04282709211111069,
0.029350200667977333,
0.06999441981315613,
0.03274315223097801,
0.05409738048911095,
-0.018459543585777283,
0.031722892075777054,
-0.030133189633488655,
-0.010605934076011181,
0.0272147785872221,
-0.01031527854502201,
-0.022338896989822388,
-0.04752502217888832,
-0.06728954613208771,
-0.010416118428111076,
0.012859990820288658,
0.003849692875519395,
0.011021154932677746,
-0.027902858331799507,
-0.011252492666244507,
0.027831677347421646,
0.003529379377141595,
-0.019123898819088936,
-0.05343302711844444,
-0.010356800630688667,
-0.04911472648382187,
-0.042945727705955505,
-0.01902899146080017,
-0.03207879886031151,
0.031343262642621994,
0.03127208352088928,
-0.0030518751591444016,
-0.025197990238666534,
-0.004288640804588795,
0.040691670030355453,
-0.053955018520355225,
-0.021698269993066788,
0.027950312942266464,
0.0032594858203083277,
0.03938668966293335,
-0.010042419657111168,
0.009905989281833172,
0.014425967819988728,
-0.004410241264849901,
-0.017878234386444092,
0.03829525038599968,
0.009366202168166637,
0.0569920651614666,
-0.04361008107662201,
-0.0031942366622388363,
-0.01991875097155571,
0.008713711984455585,
-0.028899390250444412,
0.004291606601327658,
-0.053053393959999084,
-0.00013911760470364243,
-0.02709614299237728,
-0.03943414241075516,
-0.025791162624955177,
-0.0019456074805930257,
-0.009692447260022163,
-0.0008474959759041667,
0.02446245588362217,
-0.010837270878255367,
0.005522440653294325,
-0.04474897310137749,
0.023454060778021812,
-0.0077468398958444595,
-0.01514963898807764,
0.013310803100466728,
-0.016869841143488884,
0.03143817186355591,
-0.00020445932750590146,
-0.011602464132010937,
-0.0050627319142222404,
-0.010896588675677776,
0.03917314484715462,
-0.023715058341622353,
-0.022374486550688744,
0.003520481986925006,
0.05775132402777672,
-0.0069460561498999596,
0.022398212924599648,
-0.034237947314977646,
-0.026597877964377403,
0.00011956143862335011,
0.009271294809877872,
-0.006346951238811016,
0.006275770720094442,
0.04285081848502159,
0.008844209834933281,
-0.036088645458221436,
0.012302408926188946,
-0.0021991890389472246,
0.003900112584233284,
-0.00969837885349989,
0.004279743414372206,
0.018423954024910927,
-0.010184780694544315,
-0.027807950973510742,
-0.03414303809404373,
-0.04852155223488808,
-0.0016149135772138834,
-0.013156577944755554,
-0.006222384981811047,
-0.027713043615221977,
0.013583661988377571,
0.05533117800951004,
0.01588517427444458,
-0.03241097554564476,
0.0016742309089750051,
-0.000003142542709611007,
0.017463013529777527,
-0.028970571234822273,
-0.010582206770777702,
-0.005424567498266697,
-0.023916736245155334,
-0.027238504961133003,
-0.002353413961827755,
-0.015897037461400032,
0.0384376123547554,
0.008440852165222168,
-0.03805798292160034,
-0.017700282856822014,
0.007984109222888947,
0.006750308908522129,
0.030773816630244255,
-0.01354807149618864,
-0.02363201417028904,
-0.005047902464866638,
0.02799776755273342,
-0.016419028863310814,
-0.03302787244319916,
0.011003359220921993,
0.02223212458193302,
-0.004600056912750006,
-0.017130836844444275,
-0.005000448785722256,
0.005193229764699936,
0.0031111924909055233,
-0.04337280988693237,
0.008363739587366581,
-0.004914438351988792,
-0.017688419669866562,
0.007717180997133255,
0.018210411071777344,
-0.024675996974110603,
-0.014378514140844345,
0.013334529474377632,
0.03433285281062126,
-0.014959823340177536,
0.0005420118686743081,
0.012504087761044502,
0.008197651244699955,
0.02044074237346649,
0.04688439518213272,
0.04939945042133331,
-0.0252928975969553,
0.011697372421622276,
-0.022694800049066544,
-0.018803585320711136,
-0.0008007835713215172,
0.01296676229685545,
0.010000897571444511,
0.028258763253688812,
-0.008464579470455647,
-0.023216791450977325,
0.06031383201479912,
0.02171013318002224,
0.005804197862744331,
0.023394744843244553,
-0.008304422721266747,
0.042305100709199905,
-0.007770566735416651,
-0.010647456161677837,
-0.03155680373311043,
0.021555908024311066,
-0.002083520172163844,
0.012859990820288658,
-0.02195926569402218,
-0.05751405656337738,
0.006335088051855564,
0.008695916272699833,
-0.017403695732355118,
0.0172969251871109,
0.01741556078195572,
-0.0047394526191055775,
-0.01117538008838892,
0.003600560361519456,
-0.03093990497291088,
-0.008553555235266685,
0.028804482892155647,
-0.011899051256477833,
0.0015778401866555214,
-0.005724119488149881,
-0.013903975486755371,
-0.013619252480566502,
0.02837739698588848,
-0.003606491954997182,
0.017391832545399666,
-0.021354228258132935,
0.03298041969537735,
-0.005356352310627699,
-0.012385453097522259,
0.0006042949971742928,
0.0074265263974666595,
0.04183056205511093,
-0.001359849120490253,
0.004063235130161047,
-0.029563743621110916,
-0.03143817186355591,
-0.02638433687388897,
0.01838836446404457,
-0.00693419249728322,
0.03535311296582222,
0.019954340532422066,
-0.004875882063060999,
-0.012118524871766567,
0.04342026636004448,
-0.025601347908377647,
0.013239622116088867,
0.03513956815004349,
0.018483271822333336,
-0.0416170209646225,
0.029373928904533386,
-0.04645731300115585,
0.015493679791688919,
-0.005786402616649866,
-0.05167723447084427,
-0.017213881015777588,
-0.00693419249728322,
-0.038769789040088654,
0.0024097654968500137,
-0.02325238287448883,
-0.05143996328115463,
0.0024587020743638277,
-0.014307333156466484,
0.02344219759106636,
-0.031533077359199524,
-0.02479463256895542,
0.029160385951399803,
-0.01194057334214449,
0.014176835305988789,
0.015161502175033092,
0.009123001247644424,
0.026597877964377403,
-0.03689536079764366,
-0.011323672719299793,
0.007889200933277607,
0.006477449554949999,
-0.015042867511510849,
0.004063235130161047,
-0.027807950973510742,
0.007800225168466568,
-0.01978825218975544,
-0.029611198231577873,
0.007729044649749994,
-0.018412090837955475,
-0.001536318100988865,
0.016502073034644127,
0.02823503501713276,
-0.0205000601708889,
0.03933923318982124,
-0.020132292062044144,
0.014129381626844406,
-0.03411931172013283,
0.04429816082119942,
-0.016763068735599518,
-0.02216094359755516,
-0.043704986572265625,
-0.022825298830866814,
0.009277226403355598,
0.012373588979244232,
-0.03010946325957775,
-0.01645462028682232,
-0.0047394526191055775,
0.00790699664503336,
-0.00582792516797781,
-0.01831718347966671,
-0.03504466265439987,
-0.00721891550347209,
0.0024957754649221897,
-0.030014555901288986,
-0.0004656408273149282,
0.013856521807610989,
-0.016941022127866745,
-0.025909798219799995,
-0.0044191391207277775,
0.04833173751831055,
-0.03886469826102257,
0.04702675715088844,
-0.011744826100766659,
0.060883279889822006,
0.029373928904533386,
-0.07991226762533188,
-0.033905770629644394,
0.009045888669788837,
-0.0010209990432485938,
-0.013512481935322285,
0.042494915425777435,
0.013453164137899876,
-0.016490209847688675,
0.013583661988377571,
-0.04218646511435509,
-0.027713043615221977,
0.005774539429694414,
0.006115613970905542,
0.0015044350875541568,
0.015031004324555397,
-0.027902858331799507,
-0.034285400062799454,
-0.034878574311733246,
-0.015541133470833302,
0.008666258305311203,
0.01207700278609991,
0.00983480829745531,
-0.006346951238811016,
0.01683424971997738,
-0.014485285617411137,
0.01488864328712225,
-0.030180644243955612,
-0.004383548628538847,
-0.06548630446195602,
-0.0006762172561138868,
0.0047513158060610294,
0.005952491424977779,
-0.016822386533021927,
0.04145093262195587,
-0.005433464888483286,
-0.05300594121217728,
0.029729831963777542,
-0.0005727827083319426,
0.016252940520644188,
0.023774374276399612,
0.0224100761115551,
-0.016407165676355362,
0.014081927947700024,
0.017985006794333458,
-0.017308788374066353,
-0.04107129946351051,
-0.019681481644511223,
-0.004321265500038862,
-0.007147734984755516,
0.0039297714829444885,
0.018839174881577492,
-0.07269928604364395,
-0.053195755928754807,
0.04536587372422218,
-0.03376340866088867,
-0.029255293309688568,
0.006275770720094442,
0.0291366595774889,
0.0188984926789999,
0.02664533257484436,
-0.029990827664732933,
0.02996710129082203,
0.028092674911022186,
-0.027380866929888725,
0.02823503501713276,
-0.032956693321466446,
-0.026621606200933456,
0.024177731946110725,
-0.01303794328123331,
0.021294912323355675,
0.007948518730700016,
0.0040928940288722515,
-0.04213901236653328,
0.022694800049066544,
0.005243649706244469,
-0.010131395421922207,
-0.009087410755455494,
-0.00025654732598923147,
-0.0021843595895916224,
0.025530166923999786,
0.00666133314371109,
-0.03238724544644356,
0.0020182712469249964,
-0.007402799557894468,
-0.02068987488746643,
-0.021662678569555283,
0.0010121014202013612,
0.05015870928764343,
0.016181759536266327,
0.0278554055839777,
0.005332625471055508,
-0.01773587428033352,
0.02939765527844429,
-0.007135871332138777,
-0.007812088821083307,
0.004300504457205534,
-0.028021493926644325,
0.016537664458155632,
-0.0034285399597138166,
-0.005563962738960981,
0.0563751645386219,
-0.008031562902033329,
-0.013239622116088867,
-0.014354786835610867,
-0.01806805096566677,
-0.014995413832366467,
0.008013767190277576,
0.015054731629788876,
0.02356083318591118,
-0.016881704330444336,
0.040834031999111176,
0.0068748751655220985,
0.005297034978866577,
0.0023875213228166103,
0.0045763300731778145,
0.0009950477397069335,
0.03336004912853241,
-0.0019189147278666496,
0.006667264737188816,
0.03817661479115486,
0.0297772865742445,
0.02996710129082203,
0.009170454926788807,
-0.008725575171411037,
-0.00015728353173471987,
0.014366650953888893,
0.02818758226931095,
0.028448577970266342,
0.02395232580602169,
-0.024509908631443977,
0.0027730839792639017,
-0.013536208309233189,
0.03188898041844368,
-0.011252492666244507,
-0.0017498604720458388,
0.03656318411231041,
0.024486182257533073,
0.05162978172302246,
-0.008156129159033298,
0.028401125222444534,
-0.012373588979244232,
-0.01511404849588871,
0.004439900163561106,
-0.01824600249528885,
-0.0014295469736680388,
-0.007100281305611134,
-0.07345854490995407,
0.009811081923544407,
0.008369671180844307,
0.0044280365109443665,
-0.022694800049066544,
0.035637836903333664,
0.0474063865840435,
0.024936994537711143,
-0.015066594816744328,
0.05153487250208855,
0.01162025984376669,
-0.03274315223097801,
-0.013180304318666458,
0.005068663507699966,
-0.03604119271039963,
0.04194919764995575,
-0.012515950947999954,
0.004772076848894358,
0.039291780441999435,
-0.0013390880776569247,
0.019456075504422188,
0.012800673954188824,
0.04783347249031067,
-0.014200562611222267,
0.009941579774022102,
-0.08437293022871017,
0.05096542462706566,
-0.004119586665183306,
-0.044677793979644775,
-0.022967658936977386,
0.013536208309233189,
0.0156953576952219,
0.00921790860593319,
0.04536587372422218,
0.003766648704186082,
0.01980011537671089,
0.04256609454751015,
0.020642422139644623,
0.02612333931028843,
-0.009395861066877842,
0.023987917229533195,
-0.0512501485645771,
0.008986570872366428,
-0.003123055910691619,
0.007705317344516516,
-0.01875613071024418,
0.022955795750021935,
0.04439307004213333,
0.0031022948678582907,
-0.0024320094380527735,
-0.007224847562611103,
0.017700282856822014,
-0.016371576115489006,
-0.01895781047642231,
-0.047358933836221695,
0.006898602470755577,
0.025316623970866203,
0.004896643105894327,
-0.006447790656238794,
-0.003817068412899971,
0.016893567517399788,
-0.024237049743533134,
-0.013393847271800041,
0.014947960153222084,
0.008832346647977829,
0.02920784056186676,
-0.015315727330744267,
0.013690433464944363,
0.02882820926606655,
-0.020191609859466553,
0.019230669364333153,
0.00921790860593319,
-0.010505094192922115,
0.0017928654560819268,
-0.014105654321610928,
-0.04379989579319954,
-0.03945786878466606,
-0.014864915981888771,
0.009544153697788715,
0.01543436199426651,
0.04088148474693298,
0.010878792963922024,
-0.012029549106955528,
0.03338377922773361,
-0.02754695527255535,
0.022172806784510612,
0.03214997798204422,
0.012432906776666641,
0.006489312741905451,
0.011531283147633076,
-0.015220819972455502,
-0.008672189898788929,
0.023916736245155334,
-0.018281592056155205,
0.03400067612528801,
0.015612313523888588,
-0.007545161060988903,
-0.01786637119948864,
-0.021757585927844048,
0.018969673663377762,
0.0377732589840889,
-0.02830621600151062,
-0.0035649698693305254,
-0.0015570791438221931,
-0.021152550354599953,
-0.001947090495377779,
0.021437272429466248,
0.03143817186355591,
0.053955018520355225,
0.023418471217155457,
-0.007533297408372164,
0.02389300987124443,
0.02159149758517742,
0.017724009230732918,
-0.011068608611822128,
0.012337998487055302,
0.007806156761944294,
0.010208507999777794,
0.017985006794333458,
-0.0217813141644001,
0.004852155223488808,
-0.0076697273179888725,
-0.026099612936377525,
0.02958746999502182,
0.01129994634538889,
0.027238504961133003,
0.019479801878333092,
0.008197651244699955,
0.02709614299237728,
0.006524903234094381,
0.018210411071777344,
-0.020191609859466553,
0.003956464119255543,
-0.0214491356164217,
-0.011697372421622276,
-0.0033484618179500103,
-0.03625473380088806,
-0.0007726078620180488,
0.030251823365688324,
0.009401792660355568,
-0.02901802398264408,
0.023418471217155457,
0.02203044667840004,
-0.031011085957288742,
-0.019123898819088936,
-0.02223212458193302,
0.00047935795737430453,
-0.01073050033301115,
-0.004223391879349947,
-0.04197292402386665,
-0.0018210412235930562,
-0.007005373481661081,
0.011946504935622215,
-0.02567252889275551,
0.03663436695933342,
0.024936994537711143,
0.008179855532944202,
-0.01741556078195572,
0.06325597316026688,
-0.018471408635377884,
-0.015042867511510849,
-0.05590062588453293,
0.04534214735031128,
-0.031034812331199646,
-0.05647007003426552,
-0.006987578235566616,
-0.019195079803466797,
-0.009722106158733368,
0.0156953576952219,
0.010683045722544193,
-0.017118973657488823,
0.034285400062799454,
-0.015446225181221962,
0.012907445430755615,
-0.028472304344177246,
-0.0034196425694972277,
0.0345701240003109,
-0.007177393417805433,
-0.024486182257533073,
-0.00870778039097786,
0.016537664458155632,
-0.022243987768888474,
0.01428360678255558,
-0.0035086183343082666,
0.027452047914266586,
-0.017308788374066353,
0.033644773066043854,
0.0006328414892777801,
0.0015986013459041715,
0.007770566735416651,
-0.00809681136161089,
0.009182318113744259,
-0.0015155570581555367,
-0.006602015811949968,
0.003609457751736045,
-0.0036420824471861124,
0.007966313511133194,
0.012539677321910858,
-0.0031111924909055233,
-0.0017676556017249823,
-0.012136319652199745,
0.01104488130658865,
-0.015185229480266571,
-0.03127208352088928,
0.05423974245786667,
-0.03312278166413307,
-0.013476891443133354,
0.05191450193524361,
0.01741556078195572,
0.0022570232395082712,
0.00020075199427083135,
0.02555389329791069,
0.01927812397480011,
0.0038585904985666275,
-0.007236710749566555,
0.017581649124622345,
0.03407185897231102,
-0.011323672719299793,
0.014081927947700024,
0.019444212317466736,
-0.030702635645866394,
-0.024438727647066116,
0.006744377315044403,
0.01716642640531063,
-0.010196643881499767,
0.004994516726583242,
-0.0345701240003109,
0.0034077789168804884,
0.012634585611522198,
0.020986462011933327,
0.04574550315737724,
0.01703592948615551,
-0.020844100043177605,
0.02664533257484436,
0.033217690885066986,
-0.0020924177952110767,
-0.010700841434299946,
-0.01133553683757782,
-0.01424801629036665,
-0.021947402507066727,
-0.0473826602101326,
-0.039220601320266724,
0.02268293686211109,
0.0077587030827999115,
-0.03400067612528801,
-0.018744267523288727,
0.009692447260022163,
0.013951429165899754,
-0.028994297608733177,
-0.006750308908522129,
-0.008832346647977829,
-0.0071892570704221725,
0.00646558590233326,
-0.0045763300731778145,
-0.05110778659582138,
-0.012492223642766476,
0.03048909269273281,
-0.009532290510833263,
0.014093791134655476,
0.0205000601708889,
0.012432906776666641,
0.021306775510311127,
0.011566873639822006,
0.013014215975999832,
0.0006243145908229053,
0.0021754619665443897,
-0.039552778005599976,
0.00542753329500556,
-0.021294912323355675,
0.003962395712733269,
-0.010493231005966663,
-0.017569784075021744,
-0.017237607389688492,
0.009728037752211094,
-0.004683101084083319,
-0.0035827651154249907,
-0.004766145255416632,
-0.005495748016983271,
-0.009793286211788654,
0.002280750311911106,
0.005626246333122253,
0.008992503397166729,
-0.011305877938866615,
0.015541133470833302,
0.01488864328712225,
0.012836264446377754,
-0.00010445406223880127,
-0.002857611048966646,
-0.05860549584031105,
0.025079354643821716,
-0.006275770720094442,
0.017510468140244484,
-0.031295809894800186,
0.02031024359166622,
-0.0049055409617722034,
-0.029255293309688568,
0.03786816447973251,
-0.0002532107464503497,
0.015647904947400093,
-0.013844658620655537,
-0.005706324707716703,
-0.006999441888183355,
0.0166562981903553,
0.011187243275344372,
0.01041018683463335,
0.0518670491874218,
-0.016691889613866806,
-0.000961681769695133,
-0.06230689585208893,
0.011863460764288902,
-0.04491506144404411,
-0.033265143632888794,
0.01261085830628872,
0.01133553683757782,
-0.02280157059431076,
-0.0038289318326860666,
0.025506440550088882,
0.026028431951999664,
-0.01488864328712225,
-0.00010046867828350514,
-0.0024394241627305746,
-0.004054337739944458,
0.0014080444816499949,
-0.024509908631443977,
0.013014215975999832,
0.021472863852977753,
0.015766538679599762,
-0.00017544945876579732,
0.02567252889275551,
-0.022623619064688683,
0.025506440550088882,
0.02574370987713337,
0.011110130697488785,
-0.03143817186355591,
-0.026597877964377403,
-0.00256992201320827,
-0.006851148325949907,
-0.01396329328417778,
0.013465027324855328,
0.023798102512955666,
-0.01639530248939991,
-0.012705766595900059,
0.03933923318982124,
-0.006370678078383207,
-0.00769938575103879,
-0.006963851395994425,
-0.01450901199132204,
-0.009318748489022255,
-0.0028220205567777157,
-0.019550982862710953,
0.02484208531677723,
-0.007260437589138746,
0.011294014751911163,
-0.00983480829745531,
0.013595526106655598,
-0.02023906446993351,
0.01991875097155571,
-0.023596422746777534,
-0.006038501393049955,
-0.017913825809955597,
-0.03931550681591034,
-0.06377796083688736,
-0.01952725648880005,
0.02363201417028904,
-0.029255293309688568,
-0.012598995119333267,
-0.019456075504422188,
0.0028991331346333027,
0.03248215466737747,
-0.02108136937022209,
0.012029549106955528,
0.01105081383138895,
0.0004600798129104078,
-0.0035056525375694036,
0.02363201417028904,
0.01741556078195572,
0.019384894520044327,
-0.0010187746956944466,
-0.015268273651599884,
-0.016596980392932892,
-0.00010352722893003374,
0.019479801878333092,
0.006619811058044434,
0.006845216732472181,
0.023347290232777596,
-0.0019648857414722443,
0.0034048131201416254,
0.004442865960299969,
-0.012622721493244171,
0.031011085957288742,
-0.014817462302744389,
-0.0007281198631972075,
-0.01774773746728897,
-0.004048405680805445,
-0.013903975486755371,
0.009822945110499859,
0.012082934379577637,
0.005976218264549971,
-0.00800783559679985,
0.036207281053066254,
-0.001447342219762504,
-0.02311002090573311,
-0.027048690244555473,
0.003864522324874997,
0.011709235608577728,
0.004950028844177723,
0.02004924789071083,
-0.019835706800222397,
-0.01117538008838892,
-0.007533297408372164,
-0.0038378294557332993,
-0.016371576115489006,
-0.00773497624322772,
0.002927308902144432,
0.031485624611377716,
-0.0002693376154638827,
0.002157666953280568,
0.020701738074421883,
0.0014243567129597068,
-0.014342923648655415,
-0.015932627022266388,
-0.008458646945655346,
-0.005237717647105455,
-0.00976955983787775,
0.008873868733644485,
-0.0041047572158277035,
-0.007705317344516516,
0.01450901199132204,
-0.0047453842125833035,
0.00602070614695549,
0.017664693295955658,
0.015837719663977623,
0.015790265053510666,
0.00195450522005558,
-0.02087968960404396,
0.0416407473385334,
-0.005658870562911034,
0.03419049456715584,
-0.019705208018422127,
0.0028116400353610516,
-0.030204370617866516,
0.0016653332859277725,
-0.006062228232622147,
0.03917314484715462,
-0.06472703814506531,
-0.006133409217000008,
-0.007711249403655529,
-0.0069519877433776855,
-0.013049806468188763,
0.01658511720597744,
-0.023086294531822205,
0.025648800656199455,
-0.013073533773422241,
0.0025224683340638876,
0.006299497559666634,
0.020701738074421883,
-0.009662788361310959,
0.0002561766013968736,
0.005208059214055538,
-0.04707420989871025,
0.01168550830334425,
0.007046895567327738,
-0.02799776755273342,
0.0030785680282860994,
-0.02048819698393345,
0.004365753382444382,
0.011252492666244507,
-0.010511025786399841,
-0.0010261893039569259,
0.013049806468188763,
-0.04538960009813309,
0.011798211373388767,
0.002406799467280507,
-0.004161108750849962,
0.01354807149618864,
0.037939347326755524,
0.010030555538833141,
0.006459654308855534,
0.015600450336933136,
-0.023477789014577866,
-0.0313669890165329,
0.0022688868921250105,
0.007533297408372164,
-0.018851038068532944,
0.02650297060608864,
0.02714359760284424,
0.013951429165899754,
-0.011727030389010906,
0.0233710166066885,
-0.03362104669213295,
0.012136319652199745,
0.006762172561138868,
-0.023525241762399673,
0.026360608637332916,
-0.015849582850933075,
0.008903526701033115,
0.0014999862760305405,
0.025648800656199455,
-0.029872193932533264,
0.007325686980038881,
-0.019645890220999718,
0.0012197120813652873,
0.01805618591606617,
0.00953822210431099,
0.012776946648955345,
0.028970571234822273,
0.01722574420273304,
0.016241077333688736,
0.020737329497933388,
0.01582585647702217,
0.007800225168466568,
0.017012203112244606,
-0.01882731169462204,
-0.0014710690593346953,
0.04830801114439964,
-0.0224219411611557,
0.017142700031399727,
0.008731506764888763,
0.036397095769643784,
0.0014191664522513747,
0.02227957919239998,
0.018162958323955536,
-0.03414303809404373,
-0.021413546055555344,
-0.048379190266132355,
-0.014070063829421997,
-0.0008497203816659749,
0.039671413600444794,
0.08665071427822113,
0.010350869037210941,
0.020417015999555588,
0.0208203736692667,
-0.0227303896099329,
-0.00390901044011116,
0.015517406165599823,
0.006489312741905451,
0.015766538679599762,
-0.0008208031649701297,
0.030584001913666725,
0.016217350959777832,
0.01990688592195511,
0.0009097791044041514,
0.06050364673137665,
-0.011661781929433346,
0.01927812397480011,
0.04939945042133331,
-0.017593512311577797,
0.028163855895400047,
0.009817013517022133,
0.028638392686843872,
-0.006690991576761007,
-0.006495244801044464,
-0.005851652007550001,
-0.010202576406300068,
-0.01104488130658865,
-0.025767436251044273,
0.007153666578233242,
-0.024747177958488464,
0.007770566735416651,
0.0010803163750097156,
0.01364297978579998,
-0.009864467196166515,
-0.00028991332510486245,
-0.035875104367733,
0.011305877938866615,
-0.020345835015177727,
0.010184780694544315,
-0.01811550371348858,
-0.0022155011538416147,
0.007171461824327707,
0.026408063247799873,
-0.004783940501511097,
0.01824600249528885,
0.031034812331199646,
-0.026408063247799873,
0.012563404627144337,
0.02709614299237728,
-0.007693454157561064,
-0.00028268402093090117,
0.00976955983787775,
0.01972893439233303,
-0.00838746689260006,
-0.025506440550088882,
-0.013939565978944302,
0.04209155589342117,
-0.017712146043777466,
-0.02567252889275551,
-0.03191271051764488,
-0.023608285933732986,
0.004155177157372236,
0.021366091445088387,
0.0014910886529833078,
0.020072974264621735
] | 2024-07-10 | 1 | 38985855 | [
"T cell receptors",
"T cells",
"engineered T cells",
"T cell activation",
"cancer cells",
"target cells",
"more robust T cell expansion",
"antigen",
"antigen receptor",
"other targets",
"costimulatory domains",
"STARs",
"-",
"costimulatory synthetic TCR",
"conventional CARs",
"Co",
"receptor",
"TCRs",
"antigen density",
"low densities",
"antibodies",
"other peptide-HLA antigens",
"CARs",
"cancer",
"[chimeric antigen receptors",
"high-affinity antibody fragments",
"a common human leukocyte antigen",
"high-affinity antigen-binding domains",
"patient-derived TCRs",
"MyD88"
] | [] | 0 | 10.1126/scitranslmed.adg7123 | [
"Mog",
"Marcou",
"DiNapoli",
"Pearlman",
"Nichakawade",
"Hwang",
"Douglass",
"Hsiue",
"Glavaris",
"Wright",
"Konig",
"Paul",
"Wyhs",
"Ge",
"Miller",
"Azurmendi",
"Watson",
"Pardoll",
"Gabelli",
"Bettegowda",
"Papadopoulos",
"Kinzler",
"Vogelstein",
"Zhou"
] | [
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.\nInstitute for NanoBioTechnology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.\nBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDivision of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.\nBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.",
"Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.\nBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.",
"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.",
"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.\nBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.\nDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.\nDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.",
"Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nLustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.\nBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA."
] | [
"38985855"
] | [] | 8.693698 | 4.694252 |
38985302 | 742 | CD19-directed CART therapy for T-cell/histiocyte-rich large B-cell lymphoma. | T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare histologic variant of LBCL. Limited data regarding CD19-directed chimeric antigen receptor T-cell (CART) therapy in relapsed/refractory (R/R) THRLBCL suggest poor efficacy. We investigated CART outcomes for R/R THRLBCL through the Center for International Blood and Marrow Transplant Research registry. A total of 58 adult patients with R/R THRLBCL who received commercial CD19-CART therapy between 2018 and 2022 were identified. Most patients (67%) had early relapse of disease (45% primary refractory) with a median of 3 (range, 1-7) prior therapies and were treated with axicabtagene ciloleucel (69%). At median follow-up of 23 months after CART therapy, 2-year overall and progression-free survival were 42% (95% confidence interval [CI], 27-57) and 29% (95% CI, 17-43), respectively. In univariable analysis, poor performance status before CART therapy was associated with higher mortality (hazard ratio, 2.35; 95%CI, 1.02-5.5). The 2-year cumulative incidences of relapse/progression and nonrelapse mortality were 69% and 2%, respectively. Grade ≥3 cytokine release syndrome and immune effector cell-associated neurologic syndrome occurred in 7% and 15% of patients, respectively. In this largest analysis of CD19-CART therapy for R/R THRLBCL, ∼30% of patients were alive and progression free 2 years after CART therapy. Despite a high incidence of progression (69% at 2 years), these results suggest a subset of patients with R/R THRLBCL may have durable responses with CARTs. | [
-0.01112277340143919,
0.01941383257508278,
0.04561357572674751,
0.03796029090881348,
0.01052964385598898,
0.007257864810526371,
-0.004933179821819067,
0.02648036554455757,
-0.016110165044665337,
0.01295318454504013,
0.002428323496133089,
0.0011129151098430157,
-0.024452244862914085,
0.028062043711543083,
0.023049142211675644,
-0.018316861242055893,
0.0864310935139656,
-0.023495584726333618,
-0.0005193869583308697,
0.06561416387557983,
0.028062043711543083,
-0.0029911587480455637,
0.018648503348231316,
0.011983768083155155,
-0.01784490793943405,
-0.0007924338569864631,
0.01598260924220085,
-0.004509060177952051,
-0.004340050276368856,
-0.011173795908689499,
0.007615018170326948,
-0.015357591211795807,
0.01443919725716114,
-0.009885492734611034,
-0.022666478529572487,
0.03722047433257103,
0.05724656954407692,
0.015701988711953163,
0.01841890439391136,
-0.0013257721439003944,
0.024783886969089508,
0.0022640966344624758,
0.04813916236162186,
0.06194058433175087,
-0.0524505116045475,
-0.03214379400014877,
0.027857955545186996,
-0.016607627272605896,
0.005864329170435667,
-0.009050008840858936,
-0.050282079726457596,
0.022628212347626686,
-0.055868979543447495,
0.048496313393116,
-0.07505321502685547,
0.0449247807264328,
0.0030166697688400745,
0.0018957824213430285,
0.016811715438961983,
-0.04079200699925423,
0.013622846454381943,
-0.033189743757247925,
0.011868968605995178,
-0.07740022242069244,
-0.03767967224121094,
-0.023763447999954224,
-0.07780839502811432,
-0.01234092190861702,
0.031939707696437836,
0.013189160265028477,
-0.03987361490726471,
-0.03206726163625717,
0.01790868677198887,
0.0076341512612998486,
0.01237918809056282,
0.03163357824087143,
0.002048848196864128,
0.0410471186041832,
-0.0009359329123981297,
-0.013087117113173008,
-0.005590086802840233,
-0.006779534742236137,
0.004282650537788868,
-0.011460794135928154,
-0.012691697105765343,
-0.01955414190888405,
0.012442965060472488,
-0.022079726681113243,
-0.018712280318140984,
-0.0022194525226950645,
-0.01758980005979538,
-0.007659662514925003,
-0.02457979880273342,
0.04245021939277649,
-0.003498188918456435,
-0.030944781377911568,
0.000014499387361865956,
-0.04398087412118912,
0.03576635196805,
0.0112311951816082,
0.014681550674140453,
0.019962318241596222,
0.011971012689173222,
-0.03341934457421303,
0.0373990498483181,
0.015179014764726162,
-0.054185256361961365,
0.0030613138806074858,
0.03979707881808281,
-0.029005948454141617,
0.01824032887816429,
-0.0012332949554547668,
-0.0600527748465538,
0.04370025545358658,
-0.019936807453632355,
-0.04617481678724289,
-0.01648007333278656,
-0.010287290439009666,
0.003893608693033457,
0.05255255475640297,
-0.007149443496018648,
0.008947965689003468,
0.012985073029994965,
-0.013316715136170387,
-0.0070984214544296265,
-0.016454562544822693,
0.06275693327188492,
-0.03563879430294037,
0.02773040160536766,
-0.07209394127130508,
0.055154670029878616,
0.009974781423807144,
0.0033802008256316185,
-0.035409197211265564,
-0.05760372430086136,
-0.005746341310441494,
-0.009898248128592968,
-0.015102481469511986,
-0.027041606605052948,
-0.018686769530177116,
0.0008721555932424963,
-0.0032654013484716415,
-0.020969999954104424,
0.006157705094665289,
-0.012678941711783409,
-0.008928831666707993,
0.015472390688955784,
-0.02600841224193573,
-0.0023709237575531006,
0.0051308898255229,
-0.06933876127004623,
0.0542362779378891,
0.0205235593020916,
0.013354981318116188,
-0.03385302796959877,
-0.05704248324036598,
-0.0009542689076624811,
0.0319652184844017,
-0.03982258960604668,
-0.04831773787736893,
0.01130135077983141,
-0.01935005560517311,
-0.027245692908763885,
-0.011926368810236454,
0.02836817502975464,
-0.016709672287106514,
-0.013303959742188454,
0.04117467254400253,
-0.06265489012002945,
-0.0027998266741633415,
0.017972463741898537,
-0.0504351444542408,
-0.06015481799840927,
-0.04614930599927902,
-0.03801131248474121,
-0.000005231737759459065,
0.019426587969064713,
0.006938978098332882,
0.019681697711348534,
-0.02783244475722313,
-0.016773449257016182,
0.02773040160536766,
0.02382722683250904,
-0.031403977423906326,
-0.05928744375705719,
0.02665894106030464,
0.011588349007070065,
0.003973330371081829,
-0.05112394317984581,
-0.00720046553760767,
-0.005028845742344856,
0.002984781051054597,
0.02418437972664833,
-0.015740254893898964,
-0.0007645312580280006,
-0.00005226755092735402,
0.03135295584797859,
0.033980585634708405,
-0.026531387120485306,
-0.014464708045125008,
0.02192666009068489,
-0.0022640966344624758,
-0.027500802651047707,
-0.010612554848194122,
-0.014898394234478474,
0.011416149325668812,
0.010166113264858723,
0.028240621089935303,
-0.009993914514780045,
-0.020944489166140556,
0.021952170878648758,
-0.023227719590067863,
-0.027169160544872284,
0.02267923392355442,
-0.007768083829432726,
-0.02525584027171135,
-0.026990583166480064,
0.059848684817552567,
0.05581795796751976,
0.015025949105620384,
0.014617773704230785,
0.024477755650877953,
-0.04449109360575676,
-0.008195392787456512,
-0.006438325624912977,
0.011435282416641712,
0.03410813957452774,
-0.02568952552974224,
0.008858676999807358,
-0.02329149655997753,
0.018865346908569336,
0.04464416205883026,
0.012602408416569233,
-0.02650587633252144,
0.006620091386139393,
-0.02933759056031704,
0.006549936253577471,
0.0223858579993248,
0.07546138763427734,
-0.011645748279988766,
-0.014962171204388142,
0.006058850325644016,
0.03178664296865463,
-0.0012293088948354125,
-0.017462244257330894,
-0.006875200662761927,
0.012181478552520275,
-0.08571679145097733,
0.04270532727241516,
-0.007921149954199791,
-0.012404698878526688,
0.030893759801983833,
-0.02987332083284855,
-0.02406958118081093,
0.0004544137918855995,
0.02852124162018299,
0.02648036554455757,
-0.035307154059410095,
-0.006600957829505205,
-0.021837372332811356,
0.017143357545137405,
-0.03515408933162689,
0.010312801226973534,
-0.03683780878782272,
-0.046659525483846664,
0.021658794954419136,
0.013916222378611565,
0.012851140461862087,
-0.009566606022417545,
0.032475437968969345,
-0.015548923052847385,
-0.008393102325499058,
0.02489868551492691,
-0.02081693522632122,
-0.025982901453971863,
-0.0050607346929609776,
0.06245080381631851,
-0.006243804935365915,
-0.020689379423856735,
0.028852883726358414,
-0.01182432472705841,
0.04173591360449791,
0.0015186986420303583,
-0.0376286506652832,
-0.00562516413629055,
0.02329149655997753,
0.02232208102941513,
0.009993914514780045,
-0.029107993468642235,
0.004713147878646851,
0.01762806624174118,
0.01784490793943405,
-0.006246993783861399,
-0.07188985496759415,
-0.0315825529396534,
0.015395857393741608,
0.03870011121034622,
-0.011798813939094543,
-0.02105928771197796,
0.030970292165875435,
-0.039210326969623566,
0.04020525515079498,
-0.016314251348376274,
0.0215695071965456,
0.009757937863469124,
0.02872532792389393,
0.0006545152864418924,
-0.03551124036312103,
-0.009713293984532356,
0.08250240981578827,
0.0020934923086315393,
0.022041460499167442,
0.008916076272726059,
0.012060301378369331,
-0.012047545984387398,
0.005290333181619644,
0.022232791408896446,
-0.028546752408146858,
0.013431514613330364,
-0.023699671030044556,
-0.042756348848342896,
-0.05352197214961052,
-0.005953617859631777,
0.03594492748379707,
0.025600237771868706,
-0.01963067427277565,
-0.009419918060302734,
0.012972317636013031,
0.007589507382363081,
-0.025370638817548752,
0.04206755384802818,
-0.041327737271785736,
0.06122627854347229,
-0.01687549240887165,
0.018546460196375847,
-0.0197454746812582,
0.024656333029270172,
-0.06632846593856812,
0.043649233877658844,
0.019732719287276268,
0.035664305090904236,
0.03671025484800339,
-0.028393685817718506,
0.01622496359050274,
0.0029688365757465363,
0.027322227135300636,
-0.006023772992193699,
0.03497551009058952,
0.0032749681267887354,
0.013278448954224586,
0.01991129480302334,
-0.023457316681742668,
0.0022784466855227947,
-0.0009024498285725713,
-0.02898043766617775,
0.03882766515016556,
-0.013635601848363876,
-0.01737295649945736,
-0.004033918958157301,
0.044261496514081955,
-0.0197072084993124,
0.042832884937524796,
-0.06816525757312775,
0.031939707696437836,
0.015816789120435715,
0.09035978466272354,
-0.01466879528015852,
0.004429338499903679,
-0.017066825181245804,
-0.03696536645293236,
0.021046532317996025,
-0.0027280771173536777,
0.009866359643638134,
0.016173942014575005,
0.0012564142234623432,
0.007028266321867704,
0.0448482483625412,
0.0025526892859488726,
0.004971446003764868,
0.032577481120824814,
-0.0011503843124955893,
-0.054797518998384476,
-0.0033546898048371077,
-0.020498046651482582,
0.019579652696847916,
0.010459489189088345,
0.00020966811280231923,
0.01008320227265358,
-0.040613431483507156,
0.03693985566496849,
0.012372810393571854,
-0.014541241340339184,
0.012500365264713764,
-0.03668474406003952,
-0.014247865416109562,
0.0028412819374352694,
-0.03278157114982605,
0.10030905157327652,
0.03234788402915001,
0.040358319878578186,
-0.01994956284761429,
-0.022194525226950645,
-0.023942025378346443,
-0.050715766847133636,
0.023227719590067863,
-0.00920945219695568,
-0.019898539409041405,
0.008342080749571323,
0.006913467310369015,
-0.016352517530322075,
0.000287795381154865,
0.006805045530200005,
0.04839427024126053,
-0.02701609581708908,
0.04556255415081978,
-0.022691989317536354,
-0.014031021855771542,
0.05760372430086136,
-0.02597014605998993,
0.04847080260515213,
0.02200319431722164,
-0.01780664175748825,
0.024375712499022484,
-0.04609828442335129,
0.002897087251767516,
-0.01773010939359665,
0.07306335866451263,
0.005784607492387295,
-0.011652125976979733,
-0.014732573181390762,
-0.00459515955299139,
0.04908306524157524,
-0.012985073029994965,
-0.009215829893946648,
0.012596030719578266,
0.03556226193904877,
-0.017474999651312828,
0.0252175722271204,
-0.04525642469525337,
0.0030740692745894194,
0.0015569650568068027,
0.005242499988526106,
0.025192061439156532,
-0.042934928089380264,
0.00045560961007140577,
-0.002509639598429203,
0.044797226786613464,
0.013393248431384563,
-0.05209335684776306,
0.0196689423173666,
-0.021416442468762398,
-0.01640354096889496,
-0.0009686188423074782,
0.004914046730846167,
-0.04543500021100044,
-0.000691984489094466,
0.02665894106030464,
-0.06821627914905548,
-0.04928715154528618,
0.011868968605995178,
0.028546752408146858,
-0.006600957829505205,
0.0197454746812582,
-0.0206000916659832,
-0.012468475848436356,
0.018546460196375847,
0.022092482075095177,
-0.015510656870901585,
-0.0037532984279096127,
-0.019184233620762825,
0.006202349439263344,
-0.02987332083284855,
0.004072185140103102,
0.017028558999300003,
0.03392956033349037,
0.08199218660593033,
0.0045728376135230064,
0.0071366881020367146,
0.010159735567867756,
0.013125383295118809,
0.020370492711663246,
0.01683722622692585,
-0.013763156719505787,
-0.05122598633170128,
0.0373225174844265,
0.038751132786273956,
0.022666478529572487,
-0.0020169594790786505,
-0.027271203696727753,
0.03227135166525841,
0.001989854034036398,
-0.0008039934909902513,
0.022309325635433197,
-0.013406003825366497,
-0.009719671681523323,
-0.023852737620472908,
-0.009234963916242123,
-0.0058515737764537334,
0.014005511067807674,
-0.006862445268779993,
-0.019248010590672493,
0.005979128647595644,
0.04742485284805298,
0.01737295649945736,
0.0317356213927269,
0.04466967284679413,
-0.011039863340556622,
0.04627685993909836,
-0.016199452802538872,
0.006830556783825159,
-0.03244992718100548,
0.0060205841436982155,
0.025370638817548752,
-0.02260270155966282,
-0.04002667963504791,
-0.061022188514471054,
-0.06326715648174286,
-0.015816789120435715,
-0.011397016234695911,
-0.015166259370744228,
-0.009011742658913136,
-0.023508340120315552,
-0.0017506888834759593,
-0.02364864945411682,
0.02693956159055233,
0.032756056636571884,
-0.011703147552907467,
-0.045690108090639114,
-0.03466938063502312,
-0.04645543918013573,
-0.01755153201520443,
-0.021862883120775223,
0.02493695169687271,
0.02668445184826851,
-0.01988578401505947,
0.0016000148607417941,
-0.019860273227095604,
0.010689087212085724,
-0.04441456124186516,
-0.04413394257426262,
0.0008609945070929825,
-0.006215104833245277,
0.04362372308969498,
0.0001702058652881533,
0.0197454746812582,
0.010918686166405678,
-0.0030039141420274973,
-0.024949708953499794,
0.008533412590622902,
0.025319617241621017,
0.04431251809000969,
-0.04219510778784752,
0.025192061439156532,
0.013354981318116188,
0.016824470832943916,
-0.045511532574892044,
-0.00033243955112993717,
-0.022373102605342865,
-0.007257864810526371,
-0.008208148181438446,
-0.01673518307507038,
-0.010025802999734879,
-0.024834908545017242,
-0.02310016378760338,
-0.003399333916604519,
0.016849981620907784,
0.0050607346929609776,
-0.004687637090682983,
-0.03285810351371765,
0.024516021832823753,
0.0008498334791511297,
0.0021397308446466923,
0.005599653348326683,
-0.022551678121089935,
0.018763303756713867,
-0.006001450587064028,
-0.012098567560315132,
0.002983186626806855,
0.01883983612060547,
-0.0028572261799126863,
-0.038496021181344986,
-0.05663430690765381,
-0.027526313439011574,
0.027449781075119972,
-0.014056532643735409,
0.030715182423591614,
-0.027577335014939308,
-0.01691375859081745,
-0.0215695071965456,
0.017105091363191605,
0.04489926993846893,
0.017117846757173538,
0.029643721878528595,
-0.004952312912791967,
-0.020000584423542023,
0.04183795675635338,
0.021148577332496643,
-0.03183766454458237,
-0.029184525832533836,
0.00781272817403078,
0.007972171530127525,
-0.01580403372645378,
-0.019732719287276268,
-0.020829690620303154,
-0.024987975135445595,
0.04836875945329666,
0.011511815711855888,
0.0028508484829217196,
-0.017793886363506317,
0.011492682620882988,
0.038138870149850845,
0.043725766241550446,
0.008182636462152004,
-0.030995802953839302,
0.01744948886334896,
0.015599945560097694,
-0.03030700795352459,
-0.04020525515079498,
0.04038383066654205,
-0.007449197117239237,
-0.04334310069680214,
0.029184525832533836,
0.0009654299938119948,
-0.0224623903632164,
-0.011052618734538555,
-0.02274301089346409,
-0.0011017541401088238,
0.007072910666465759,
-0.0030373972840607166,
-0.0028205541893839836,
-0.00410088524222374,
0.015102481469511986,
-0.006387304048985243,
0.028036532923579216,
-0.009566606022417545,
-0.03048558346927166,
0.02192666009068489,
0.00781272817403078,
-0.0031697354279458523,
0.007417308632284403,
0.010478622280061245,
0.025536460801959038,
-0.0036034216172993183,
-0.02285780943930149,
0.03614901378750801,
0.003928686026483774,
-0.018406148999929428,
-0.018788814544677734,
0.01730917952954769,
0.002187563804909587,
-0.019566897302865982,
-0.04183795675635338,
0.008852299302816391,
0.011180173605680466,
-0.0028524429071694613,
-0.019209744408726692,
-0.00720046553760767,
0.036302078515291214,
0.031327445060014725,
0.08127788454294205,
-0.001085809781216085,
0.006798667833209038,
-0.029184525832533836,
0.025944635272026062,
-0.014834617264568806,
0.030281497165560722,
-0.013635601848363876,
-0.0038585311267524958,
0.010593421757221222,
-0.0196689423173666,
0.08648211508989334,
-0.005057545844465494,
0.024209890514612198,
-0.016505584120750427,
-0.007041021715849638,
0.0026116834487766027,
-0.0010786347556859255,
-0.002307146554812789,
-0.018571970984339714,
0.006958111189305782,
0.004965068306773901,
-0.0026642996817827225,
-0.031327445060014725,
-0.055511824786663055,
0.0025622558314353228,
0.029107993468642235,
0.02192666009068489,
0.0187760591506958,
-0.00037130387499928474,
0.017793886363506317,
-0.020893467590212822,
-0.003581099445000291,
0.000015732583051430993,
0.008086971007287502,
-0.019043924286961555,
0.009757937863469124,
0.014337153173983097,
-0.00827830284833908,
0.0025574725586920977,
-0.03915930539369583,
0.03563879430294037,
0.020765911787748337,
0.04640441760420799,
-0.0374755822122097,
0.029005948454141617,
-0.012889406643807888,
-0.018214818090200424,
-0.04410843178629875,
0.015561678446829319,
0.01191361341625452,
-0.02264096774160862,
0.01501319371163845,
-0.04517989233136177,
-0.00004932781303068623,
-0.03209277242422104,
0.024694599211215973,
-0.004365561064332724,
0.042220622301101685,
0.007512974552810192,
0.013750401325523853,
0.03227135166525841,
0.020153649151325226,
-0.03972054645419121,
-0.03502653166651726,
0.036097992211580276,
0.04944021999835968,
-0.045588064938783646,
0.04676156863570213,
-0.022526167333126068,
0.0006911872769705951,
0.011900858022272587,
-0.020842446014285088,
-0.018278595060110092,
-0.030179452151060104,
-0.02357211709022522,
0.03385302796959877,
-0.016747938469052315,
-0.0022800411097705364,
-0.0007920352509245276,
0.023801716044545174,
0.016543850302696228,
-0.05495058372616768,
-0.04489926993846893,
0.01693926937878132,
-0.013406003825366497,
0.01562545634806156,
0.042144086211919785,
-0.004496304783970118,
-0.018725035712122917,
-0.029184525832533836,
0.020549070090055466,
0.0102809127420187,
0.00188940460793674,
-0.003206407418474555,
-0.019503120332956314,
-0.054083213210105896,
0.027806933969259262,
-0.018036240711808205,
-0.031072335317730904,
-0.017526021227240562,
0.006830556783825159,
0.010912308469414711,
-0.017526021227240562,
-0.03464386984705925,
-0.036378614604473114,
0.01604638621211052,
-0.01178605854511261,
0.00435280567035079,
-0.008265547454357147,
-0.01501319371163845,
-0.009056386537849903,
-0.011097262613475323,
0.032756056636571884,
-0.011543704196810722,
0.01492390502244234,
-0.006215104833245277,
0.0019117267802357674,
0.004247573204338551,
-0.010759242810308933,
-0.017258156090974808,
0.0019755042158067226,
-0.027143649756908417,
-0.006785912439227104,
0.005991884041577578,
-0.03714394196867943,
0.006945355795323849,
-0.02693956159055233,
0.013016961514949799,
-0.029975365847349167,
-0.0093880295753479,
-0.007085666060447693,
0.0073152645491063595,
-0.014592262916266918,
-0.0059057846665382385,
-0.0018941879970952868,
0.03316423296928406,
0.023457316681742668,
-0.08357387036085129,
-0.016212208196520805,
-0.01673518307507038,
-0.022015949711203575,
0.007181331980973482,
0.0017698220908641815,
-0.03227135166525841,
-0.004413394257426262,
-0.0007960213115438819,
-0.005912162363529205,
0.0016789393266662955,
-0.026250766590237617,
-0.01820206269621849,
-0.0009470939985476434,
-0.035842884331941605,
0.011728658340871334,
0.002192347077652812,
-0.00103000458329916,
0.023227719590067863,
0.019375566393136978,
-0.02872532792389393,
0.05183824896812439,
0.004053052049130201,
0.05842007324099541,
-0.014745328575372696,
0.003160168882459402,
-0.027934489771723747,
0.0003611393622122705,
-0.019579652696847916,
0.004304972477257252,
0.043547190725803375,
0.009018120355904102,
-0.0197454746812582,
-0.01683722622692585,
-0.01112277340143919,
-0.0673489049077034,
0.011218439787626266,
-0.004381505306810141,
-0.006530802696943283,
0.0044261496514081955,
0.01325293816626072,
0.00976431556046009,
0.0038393978029489517,
0.001454124110750854,
0.0016980725340545177,
-0.00048550523933954537,
-0.042042043060064316,
-0.02174808457493782,
0.005708074662834406,
-0.019324542954564095,
0.04632788151502609,
-0.010370200499892235,
0.00263719423674047,
0.0010563126998022199,
-0.022475145757198334,
-0.014477463439106941,
0.003287723520770669,
-0.01377591211348772,
-0.02632729895412922,
-0.018227573484182358,
0.004713147878646851,
0.042297154664993286,
0.03178664296865463,
-0.037450071424245834,
0.018367882817983627,
-0.021327152848243713,
-0.04660850390791893,
0.04012872278690338,
-0.02547268196940422,
0.02422264590859413,
0.014043777249753475,
0.005261633079499006,
-0.03995014727115631,
0.013763156719505787,
0.00596637325361371,
0.027602847665548325,
-0.0035779105965048075,
0.004250762052834034,
0.006087549962103367,
-0.004142340272665024,
0.013495291583240032,
-0.05265459790825844,
-0.0014812294393777847,
-0.0007342370226979256,
0.008495146408677101,
-0.02403131313621998,
0.022194525226950645,
0.021365419030189514,
-0.022870564833283424,
0.022181769832968712,
-0.021505730226635933,
-0.0027105382177978754,
0.00026945938589051366,
-0.02375069260597229,
0.02872532792389393,
-0.006476592272520065,
-0.022373102605342865,
-0.04130222648382187,
0.003469489049166441,
-0.032194819301366806,
0.020625602453947067,
-0.02515379525721073,
0.011294973082840443,
-0.004135962575674057,
-0.006651979871094227,
-0.02206697128713131,
0.022768521681427956,
-0.009496450424194336,
0.011881723999977112,
-0.04714423418045044,
0.0205618254840374,
-0.014260620810091496,
0.03216930478811264,
-0.016288740560412407,
0.016467317938804626,
0.01135875005275011,
0.04341963678598404,
-0.012564142234623432,
0.037781715393066406,
0.006227860227227211,
0.049389198422431946,
0.02676098607480526,
-0.0030629083048552275,
-0.03556226193904877,
-0.010714598931372166,
0.00913291983306408,
0.02202870510518551,
-0.008992609567940235,
0.014656039886176586,
0.002152486238628626,
0.013635601848363876,
-0.004088129382580519,
-0.018648503348231316,
-0.008648212067782879,
-0.002428323496133089,
0.021110311150550842,
0.022730255499482155,
0.0233170073479414,
0.002434701193124056,
0.01350804790854454,
0.010453111492097378,
0.008699233643710613,
-0.020255694165825844,
0.0013480941997841,
0.02088071219623089,
-0.023801716044545174,
-0.02773040160536766,
0.02396753616631031,
-0.024873174726963043,
0.011881723999977112,
-0.002267285482957959,
0.02410784736275673,
0.03280708193778992,
0.03385302796959877,
-0.007761706132441759,
0.032398905605077744,
0.013597335666418076,
-0.012545009143650532,
-0.05331788212060928,
0.016645893454551697,
-0.02113582193851471,
0.06576722860336304,
-0.014592262916266918,
-0.03369996324181557,
0.034949999302625656,
-0.019477609544992447,
-0.009273230098187923,
-0.017028558999300003,
0.006805045530200005,
0.015383101999759674,
0.006454269867390394,
-0.06673664599657059,
0.03614901378750801,
-0.0030326140113174915,
-0.05979766324162483,
-0.005679375026375055,
0.016786204650998116,
0.01984751783311367,
0.041251204907894135,
0.039465438574552536,
-0.00709204375743866,
-0.0035236997064203024,
-0.014911149628460407,
0.026735475286841393,
-0.000649333349429071,
-0.019822007045149803,
-0.01651833951473236,
-0.01862299256026745,
0.014018266461789608,
0.0068496898747980595,
-0.019337300211191177,
-0.009030875749886036,
0.04155733436346054,
0.037603139877319336,
0.0197072084993124,
-0.033266276121139526,
-0.015166259370744228,
0.011709525249898434,
-0.038674600422382355,
-0.03650616854429245,
-0.017870420590043068,
0.05637919530272484,
0.05938949063420296,
-0.006333093158900738,
0.002873170655220747,
0.021072043105959892,
0.005523120518773794,
-0.028750838711857796,
-0.03650616854429245,
0.04908306524157524,
0.025192061439156532,
0.033546898514032364,
-0.04023076593875885,
0.0025670393370091915,
0.021697061136364937,
0.006575447041541338,
-0.014490218833088875,
0.01440093107521534,
-0.02773040160536766,
-0.029082482680678368,
-0.04086853936314583,
-0.04316452518105507,
0.024426734074950218,
-0.020013339817523956,
0.025957390666007996,
-0.004971446003764868,
0.040817517787218094,
0.003297290066257119,
-0.028776349499821663,
0.008029570803046227,
-0.012136833742260933,
0.0216077733784914,
0.026059433817863464,
-0.010918686166405678,
-0.011345994658768177,
-0.013750401325523853,
0.011511815711855888,
-0.014592262916266918,
-0.023482829332351685,
-0.021008266136050224,
0.06602233648300171,
-0.0037405428010970354,
-0.016990292817354202,
-0.0027392380870878696,
-0.028036532923579216,
0.014809105545282364,
0.02984781004488468,
-0.05444036424160004,
-0.03599594905972481,
0.014171332120895386,
-0.0011854618787765503,
0.009024498052895069,
0.0002778301713988185,
0.03441426903009415,
0.05821598693728447,
-0.005268010776489973,
-0.011671259067952633,
-0.002879548352211714,
0.01409479882568121,
0.004620670806616545,
-0.02887839451432228,
-0.02683751843869686,
0.00709204375743866,
-0.010567910969257355,
-0.009483695030212402,
-0.019286276772618294,
-0.0027105382177978754,
-0.00959849450737238,
-0.016237718984484673,
0.013839690014719963,
-0.0023868682328611612,
-0.013367737643420696,
-0.020013339817523956,
0.00015555699064861983,
0.006862445268779993,
-0.022704744711518288,
0.045230913907289505,
-0.000817944819573313,
0.014426441863179207,
0.009343384765088558,
-0.010274535045027733,
-0.007659662514925003,
-0.025421660393476486,
0.01816379651427269,
0.03640412539243698,
0.017500510439276695,
0.008284680545330048,
-0.031123356893658638,
-0.007742573041468859,
-0.030944781377911568,
-0.014809105545282364,
0.012538631446659565,
0.004416583105921745,
0.020319471135735512,
0.005813307594507933,
-0.013431514613330364,
-0.032577481120824814,
-0.027679380029439926,
0.015446879900991917,
0.01399275567382574,
0.03474591299891472,
0.02010262757539749,
0.010044936090707779,
-0.03227135166525841,
-0.01201565656810999,
0.02357211709022522,
-0.007417308632284403,
-0.04459314048290253,
0.013967244885861874,
-0.02818959765136242,
-0.061175256967544556,
0.025383394211530685,
-0.0053254105150699615,
-0.017398467287421227,
-0.006148138549178839,
-0.00115118152461946,
-0.0037405428010970354,
-0.009534717537462711,
-0.0006772359483875334,
-0.03030700795352459,
-0.0028524429071694613,
-0.0028173653408885,
0.004142340272665024,
-0.013189160265028477,
-0.027500802651047707,
0.028572263196110725,
-0.024707354605197906,
0.020370492711663246,
-0.0009837659308686852,
-0.005628352984786034,
-0.003998841159045696,
0.009445428848266602,
-0.01741122268140316,
0.00344397802837193,
0.015574434772133827,
0.0040945070795714855,
0.003373822895810008,
-0.0027408325113356113,
0.004709959030151367,
-0.04589419811964035,
0.022755766287446022,
0.005245688837021589,
-0.004910857882350683,
-0.010440356098115444,
0.02382722683250904,
0.006722135003656149,
0.0031681410036981106,
-0.02834266424179077,
-0.019924050197005272,
-0.02773040160536766,
0.06995102018117905,
-0.01273634098470211,
-0.038955219089984894,
0.027041606605052948,
-0.005883462727069855,
0.023814471438527107,
0.00032008267589844763,
0.036990877240896225,
-0.007015510927885771,
0.026735475286841393,
-0.008865054696798325,
0.029618211090564728,
0.01364835724234581,
-0.008507901802659035,
0.020587336272001266,
0.037450071424245834,
-0.016849981620907784,
0.009681405499577522,
0.015561678446829319,
0.012455720454454422,
0.009885492734611034,
-0.0006696624332107604,
-0.002464995486661792,
0.0022082915529608727,
-0.000722278724424541,
0.017181623727083206,
0.028215110301971436,
0.02941412478685379,
0.02278127707540989,
0.03464386984705925,
0.00664560217410326,
-0.01364835724234581,
-0.021952170878648758,
-0.026888540014624596,
-0.03737353906035423,
-0.023635894060134888,
0.004910857882350683,
-0.007436441723257303,
0.0102617796510458,
-0.03808784857392311,
0.012710830196738243,
0.015446879900991917,
0.019605163484811783,
0.022411368787288666,
-0.04007770121097565,
-0.0028572261799126863,
0.01844441518187523,
0.02582983486354351,
0.025357883423566818,
-0.006575447041541338,
-0.01600812003016472,
-0.02418437972664833,
0.0107656205072999,
-0.005111756268888712,
0.0012994639109820127,
0.030536605045199394,
0.0017634443938732147,
0.002833309816196561,
0.023801716044545174,
-0.002141325268894434,
-0.022653723135590553,
-0.0007820700411684811,
-0.056124087423086166,
0.002964053303003311,
-0.0015609512338414788,
-0.012749096378684044,
-0.012985073029994965,
-0.016378028318285942,
-0.041327737271785736,
-0.011058996431529522,
0.004378316458314657,
0.006144949700683355,
-0.04023076593875885,
-0.002125381026417017,
-0.03898072987794876,
-0.01350804790854454,
-0.0025223949924111366,
0.03260299190878868,
-0.03571532666683197,
0.020510802045464516,
-0.004515437874943018,
0.014834617264568806,
0.023495584726333618,
0.013074361719191074,
-0.04936368763446808,
0.012436587363481522,
-0.014656039886176586,
0.011473549529910088,
-0.012729963287711143,
0.0035077554639428854,
0.017602555453777313,
0.006007828284054995,
0.06663459539413452,
-0.007933905348181725,
-0.006049283780157566,
0.005236122291535139,
-0.010382955893874168,
-0.007551240734755993,
0.029796788468956947,
0.011690392158925533,
-0.01193274650722742,
0.015179014764726162,
-0.011939124204218388,
-0.02582983486354351,
-0.023559361696243286,
-0.017742864787578583,
-0.02228381298482418,
-0.01395448949187994,
0.0005959198460914195,
-0.005669808480888605,
0.007544863037765026,
-0.008654589764773846,
-0.009949269704520702,
0.0335213877260685,
0.017219889909029007,
0.005322221666574478,
-0.024516021832823753,
-0.02719467133283615,
-0.01780664175748825,
-0.013469780795276165,
0.020663868635892868,
0.008271925151348114,
0.022258302196860313,
0.006836934480816126,
0.018827080726623535,
-0.02454153262078762,
0.021046532317996025,
0.019477609544992447,
0.02185012772679329,
0.0030788525473326445,
-0.021467464044690132,
0.013138138689100742,
0.005931295454502106,
-0.002783882198855281,
0.020931733772158623,
0.015255547128617764,
-0.018495438620448112,
-0.010771998204290867,
0.017219889909029007,
0.007009133230894804,
0.014656039886176586,
0.01488563884049654,
0.015523412264883518,
0.00263719423674047,
0.013112627901136875,
0.010198001749813557,
-0.033087700605392456,
-0.031072335317730904,
0.01006406918168068,
-0.014120310544967651,
-0.03642963618040085,
-0.021263375878334045,
-0.006677490659058094,
-0.03775620460510254,
0.008986231870949268,
0.003935063723474741,
-0.038853175938129425,
-0.03334280848503113,
-0.024337444454431534,
0.018278595060110092,
-0.024311933666467667,
-0.018316861242055893,
-0.006521236151456833,
0.016901003196835518,
0.05211886763572693,
0.021378174424171448,
0.0027344548143446445,
0.02163328416645527,
0.010778375901281834,
0.02977127768099308,
0.012832007370889187,
0.008099726401269436,
0.012200611643493176,
-0.028062043711543083,
-0.024745620787143707,
0.004448471590876579,
-0.0032558348029851913,
0.04456762596964836,
-0.03533266484737396,
0.0413532480597496,
0.01431164238601923,
-0.047807518392801285,
0.02872532792389393,
-0.012576897628605366,
-0.01705406978726387,
0.0215312410145998,
0.016709672287106514,
-0.011479927226901054,
-0.0002519206318538636,
0.0017156113171949983,
-0.0013209888711571693,
0.031403977423906326,
0.01862299256026745,
0.010472244583070278,
-0.0004308958596084267,
0.026709962636232376,
0.04658299311995506,
0.006428759079426527,
-0.03084273636341095,
0.010051313787698746,
0.041072629392147064,
0.0005536673124879599,
0.009560228325426579,
0.01662038266658783,
-0.00779359508305788,
-0.04997595027089119,
-0.022041460499167442,
0.00866734515875578,
-0.02665894106030464,
-0.022015949711203575,
-0.020332226529717445,
-0.004049863200634718,
0.010689087212085724,
0.028138576075434685,
-0.009330629371106625,
0.030281497165560722,
-0.037526607513427734,
0.010835775174200535,
-0.02783244475722313,
-0.0026945939753204584,
-0.015217280946671963,
0.017755620181560516,
-0.012538631446659565,
-0.010689087212085724,
0.0045728376135230064,
0.009866359643638134,
0.003912741784006357,
-0.01730917952954769,
-0.014872883446514606,
-0.0373990498483181,
-0.017003048211336136,
-0.030970292165875435,
-0.015880566090345383,
0.011926368810236454,
0.019222499802708626,
-0.00789563823491335,
-0.06311408430337906,
0.005395565647631884,
0.017079580575227737,
-0.012761851772665977,
-0.05069025605916977,
0.011505438014864922,
-0.014834617264568806,
0.002152486238628626,
0.005114945117384195,
0.005111756268888712,
0.0036735767498612404,
0.005727208219468594,
-0.02808755449950695,
0.020829690620303154,
-0.04334310069680214,
-0.020727645605802536,
0.0016191480681300163,
-0.027271203696727753,
-0.00479924725368619,
-0.0024474565871059895,
-0.0335213877260685,
-0.02228381298482418,
-0.006492536514997482,
-0.005685752723366022,
-0.016492828726768494,
-0.016416296362876892,
0.007321642246097326,
-0.002879548352211714,
0.0008809249266050756,
0.023061897605657578,
-0.019975073635578156,
-0.011837080121040344,
0.0107273543253541,
0.0524505116045475,
0.007002755533903837,
0.03209277242422104,
-0.012149589136242867,
0.022181769832968712,
-0.017602555453777313,
0.023635894060134888,
-0.02755182422697544,
-0.0252175722271204,
0.04046036675572395,
-0.01898014545440674,
-0.013712135143578053,
0.01802348531782627,
-0.011798813939094543,
-0.026556897908449173,
0.008144370280206203,
-0.0002270075783599168,
-0.03535817563533783,
0.007328019943088293,
-0.008106104098260403,
0.020153649151325226,
-0.027577335014939308,
0.026097699999809265,
0.00120220344979316,
-0.007576751988381147,
-0.011020730249583721,
0.039746057242155075,
0.002597333397716284,
-0.00562516413629055,
0.007704306393861771,
0.0067348903976380825,
-0.018406148999929428,
0.012532253749668598,
-0.0019228877499699593,
0.009981159120798111,
0.025893613696098328,
-0.002803015522658825,
-0.01955414190888405,
0.015778521075844765,
-0.04130222648382187,
-0.015855055302381516,
0.004285839386284351,
0.005025656893849373,
0.015038704499602318,
0.03369996324181557,
0.02206697128713131,
-0.013406003825366497,
0.018865346908569336,
-0.013712135143578053,
-0.014388174749910831,
0.013712135143578053,
-0.003986085765063763,
-0.020663868635892868,
-0.01755153201520443,
-0.005232933443039656,
0.07515525817871094,
-0.008035948500037193,
0.00697724474593997,
0.02507726289331913,
-0.023521095514297485,
-0.006119438912719488,
0.018355127424001694,
-0.0026706773787736893,
-0.004569648765027523,
-0.0007792797405272722,
-0.010504133068025112,
0.021123066544532776,
0.03109784610569477,
0.007366286590695381,
0.006562691647559404,
-0.027883466333150864,
0.008361213840544224,
0.03597043827176094,
0.0027790989261120558,
-0.004579215310513973,
0.0015936370473355055,
0.016071897000074387,
-0.026786496862769127,
0.00114161497913301,
-0.0022098859772086143,
-0.016059141606092453,
0.0098727373406291,
0.03395507484674454,
-0.02188839390873909,
-0.019362810999155045,
0.03507755324244499,
0.011033485643565655,
-0.004285839386284351,
-0.008648212067782879,
-0.018852591514587402,
0.03472040221095085,
-0.015230036340653896,
-0.01651833951473236,
-0.005494420416653156,
0.01227076631039381,
-0.012430209666490555,
-0.014694306999444962,
-0.017653577029705048,
0.011065374128520489,
0.03298565745353699,
-0.017870420590043068,
-0.029005948454141617,
-0.007806350477039814,
-0.0022704745642840862,
0.025281351059675217,
-0.023023631423711777,
-0.01744948886334896,
0.031761132180690765,
-0.003212785115465522,
-0.028776349499821663,
-0.016314251348376274,
0.004716336727142334,
-0.017653577029705048,
-0.015599945560097694,
-0.03474591299891472,
-0.04140426963567734,
-0.003970141522586346,
-0.004206117708235979,
0.007799972780048847,
0.004104074090719223
] | 2024-07-10 | 21 | 38985302 | [
"CART therapy",
"%",
"R/R THRLBCL",
"THRLBCL",
"CART outcomes",
"Most patients",
"commercial CD19-CART therapy",
"patients",
"CARTs",
"higher mortality",
"CD19-CART therapy",
"progression",
"Marrow Transplant Research",
"nonrelapse mortality",
"45% primary refractory",
"early relapse",
"Grade ≥3 cytokine release syndrome and immune effector cell-associated neurologic syndrome",
"95% confidence interval",
"International Blood",
"poor efficacy",
"univariable analysis",
"hazard ratio",
"CD19-directed chimeric antigen receptor T-cell (CART) therapy",
"relapsed/refractory (R/R",
"axicabtagene ciloleucel",
"15%",
"2%",
"29%",
"42%",
"45%"
] | [] | 0 | 10.1182/bloodadvances.2024013863 | [
"Pophali",
"Fein",
"Ahn",
"Allbee-Johnson",
"Ahmed",
"Awan",
"Farhan",
"Grover",
"Hilal",
"Iqbal",
"Maakaron",
"Modi",
"Nasrollahi",
"Schachter",
"Sauter",
"Hamadani",
"Herrera",
"Shouval",
"Shadman"
] | [
"Division of Hematology, Medical Oncology and Palliative Care, University of Wisconsin, Carbone Cancer Center, Madison, WI.",
"Division of Hematology and Oncology, Weill Cornell Medicine, New York, NY.",
"Division of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, WI.",
"Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.",
"Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Cancer Center, Kansas City, KS.",
"Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX.",
"Henry Ford Health System Stem Cell Transplant & Cellular Therapy Program, Detroit, MI.",
"Division of Hematology, University of North Carolina, Chapel Hill, NC.",
"Division of Hematology and Oncology, Mayo Clinic, Phoenix, AZ.",
"Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.",
"Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN.",
"Karmanos Cancer Institute, Wayne State University, Detroit, MI.",
"Department of Internal Medicine, University of Pittsburgh Medical Center in Central Pa., Harrisburg, PA.",
"University of California Los Angeles, Los Angeles, CA.",
"Department of Hematology and Medical Oncology, Blood and Marrow Transplant Program, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.",
"Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.\nDepartment of Medicine, Blood and Marrow Transplant and Cellular Therapy Program, Medical College of Wisconsin, Milwaukee, WI.",
"Division of Lymphoma, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.",
"Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY.\nDepartment of Medicine, Weill Cornell Medical College, New York, NY.",
"Fred Hutchinson Cancer Center and University of Washington, Seattle, WA."
] | [
"38985302",
"26980727",
"35732829",
"24244368",
"30213827",
"32871584",
"0",
"31287335",
"37422194",
"37419325",
"29226797",
"32888407",
"33881502",
"25113753",
"17242396",
"30592986",
"15994282",
"30501490",
"35609867",
"37026796",
"30620669"
] | [] | 6.481336 | 5.511043 |
38983927 | 743 | Salvage CD20-SD-CART therapy in aggressive B-cell lymphoma after CD19 CART treatment failure. | Patients with relapsed/refractory aggressive B-cell lymphoma(r/r aBCL)who progressed after CD19-specific chimeric antigen receptor T-cell therapy (CD19CART) had a poor prognosis. Application of CAR T-cells targeting a second different antigen (CD20) expressed on the surface of B-cell lymphoma as subsequent anti-cancer salvage therapy (CD20-SD-CART) is also an option. This study aimed to evaluate the survival outcome of CD20-SD-CART as a salvage therapy for CD19 CART treatment failure.
This retrospective cohort study enrolled patients with aBCL after the failure of CD19 CART treatment at Beijing Gobroad Boren Hospital from December 2019 to May 2022. Patients were subsequently treated with CD20CART therapy or non-CART therapy (polatuzumab or non-polatuzumab).
A total of 93 patients were included in the study, with 54 patients receiving CD20-SD-CART therapy. After a median follow-up of 18.54 months, the CD20-SD-CART group demonstrated significantly longer median progression-free survival (4.04 months vs. 2.27 months, p=0.0032) and median overall survival (8.15 months vs. 3.02 months, p<0.0001) compared to the non-CART group. The complete response rate in the CD20-SD-CART group (15/54, 27.8%) was also significantly higher than the non-CART group (3/38, 7.9%, p=0.03). Multivariate analysis further confirmed that CD20CART treatment was independently associated with improved overall survival (HR, 0.28; 95% CI, 0.16-0.51; p<0.0001) and progression-free survival (HR, 0.46; 95% CI, 0.27-0.8; p=0.005).
CD20-SD-CART could serve as an effective therapeutic option for patients with relapsed or refractory aggressive B-cell lymphoma after CD19CART treatment failure. | [
0.021535780280828476,
0.01601015217602253,
0.02866714634001255,
0.046660859137773514,
-0.0005741103668697178,
0.023188745602965355,
-0.007485572714358568,
0.02684888429939747,
0.03034372627735138,
-0.0018979586893692613,
-0.01948137953877449,
-0.03657776862382889,
-0.03140634670853615,
0.0228109247982502,
0.06404060870409012,
-0.00307569676078856,
0.046023283153772354,
-0.023070676252245903,
-0.007963752374053001,
0.050061244517564774,
0.018064552918076515,
0.009982731193304062,
0.007686289958655834,
0.0068125794641673565,
-0.022303229197859764,
-0.025715421885252,
0.023047063499689102,
0.03027288429439068,
0.022102510556578636,
-0.05313103646039963,
0.014487062580883503,
-0.013200110755860806,
-0.03603465110063553,
-0.010874152183532715,
-0.013318180106580257,
0.05516182258725166,
0.05346162989735603,
-0.0009423379669897258,
-0.014711393974721432,
-0.04347299411892891,
0.01682482846081257,
-0.02975338138639927,
0.035184554755687714,
0.05667310580611229,
-0.028832443058490753,
-0.042646512389183044,
0.009020469151437283,
-0.050627972930669785,
0.030225656926631927,
-0.007497379556298256,
-0.04396888613700867,
0.035279009491205215,
-0.03952949121594429,
0.046141352504491806,
-0.05251707881689072,
0.023849932476878166,
-0.0228109247982502,
-0.00847144890576601,
-0.0025975173339247704,
-0.02569180727005005,
0.025951560586690903,
-0.013873104006052017,
0.02913942188024521,
-0.005552193149924278,
-0.051289159804582596,
-0.03546791896224022,
-0.028454622253775597,
0.0005715276347473264,
-0.008394704200327396,
0.004368552006781101,
-0.023684635758399963,
0.006647283211350441,
0.032374512404203415,
-0.004471862222999334,
0.0027288689743727446,
0.030461793765425682,
0.036341629922389984,
0.03244535252451897,
-0.005687972530722618,
-0.010248386301100254,
0.0061927177011966705,
0.03560960292816162,
-0.004516138229519129,
-0.0429062657058239,
-0.005572855472564697,
-0.014428027905523777,
0.001604262157343328,
-0.029517242684960365,
-0.003409241558983922,
-0.0014470828464254737,
-0.007509186398237944,
0.013034814037382603,
-0.055917464196681976,
0.029517242684960365,
-0.0058296555653214455,
0.010277903638780117,
0.00508582079783082,
-0.05535073205828667,
0.06130141019821167,
0.0018477793782949448,
0.022787312045693398,
-0.0002095724194077775,
0.026754429563879967,
-0.046117741614580154,
0.026093242689967155,
0.0022595450282096863,
-0.051619753241539,
-0.0014603656018152833,
0.037002816796302795,
-0.02460557408630848,
0.03223282843828201,
-0.005050400272011757,
-0.0401906780898571,
0.0456690788269043,
0.0013186828000470996,
-0.06677980720996857,
-0.050627972930669785,
-0.046613629907369614,
0.006971972528845072,
0.02524314634501934,
-0.0036512829829007387,
0.051619753241539,
0.025030622258782387,
-0.009244800545275211,
-0.012054841965436935,
-0.04335492476820946,
0.052375394850969315,
-0.058184389024972916,
-0.013377214781939983,
-0.07561136782169342,
0.024168718606233597,
0.0009939931333065033,
-0.009658041410148144,
-0.059742897748947144,
-0.047888774424791336,
-0.005729296710342169,
-0.020461352542042732,
0.0002687913947738707,
-0.06120695546269417,
-0.00017848708375822753,
0.014368994161486626,
-0.055964693427085876,
-0.039812855422496796,
-0.003884469158947468,
-0.03539707884192467,
-0.02980060875415802,
0.014746814034879208,
-0.02184275910258293,
-0.031075753271579742,
0.012538924813270569,
-0.08075917512178421,
0.06375724077224731,
0.03395663574337959,
0.005118289962410927,
0.013105656020343304,
-0.034570593386888504,
-0.016541462391614914,
0.024322208017110825,
-0.04829020798206329,
-0.06026240438222885,
-0.010224772617220879,
-0.019375117495656013,
-0.013117462396621704,
-0.023354042321443558,
0.03317737951874733,
0.0002582758606877178,
-0.01984739489853382,
0.03360242769122124,
-0.07055801898241043,
0.031335506588220596,
0.01623448356986046,
-0.025502897799015045,
-0.04699144884943962,
-0.05025015398859978,
-0.041489437222480774,
-0.002575379330664873,
-0.006682703737169504,
0.016411587595939636,
-0.006422951817512512,
-0.03383856639266014,
0.03088684193789959,
-0.01711999997496605,
0.015573297627270222,
-0.03282317519187927,
-0.0430951751768589,
0.011682924814522266,
0.015006566420197487,
-0.024003421887755394,
-0.018383339047431946,
0.012857710942626,
-0.005248165689408779,
-0.038159891963005066,
0.049588967114686966,
-0.015903890132904053,
-0.03837241604924202,
0.002742151962593198,
0.0315716415643692,
0.028265710920095444,
-0.030225656926631927,
0.006830289959907532,
-0.008170372806489468,
-0.032870400696992874,
-0.02699056640267372,
-0.002783475909382105,
-0.0515725277364254,
0.021394098177552223,
-0.021642042323946953,
0.012857710942626,
0.013518896885216236,
-0.03945865109562874,
0.04118245840072632,
0.009463228285312653,
-0.06064022332429886,
0.013979366049170494,
-0.021960828453302383,
-0.07206930220127106,
-0.016753986477851868,
0.06248209998011589,
0.01800551824271679,
0.0035892967134714127,
-0.0015776966465637088,
0.02083917334675789,
-0.0037959173787385225,
0.006623669061809778,
0.01807636022567749,
0.03624717518687248,
0.031146595254540443,
-0.028832443058490753,
-0.03268149122595787,
-0.046637244522571564,
0.0011253448901697993,
0.026612745597958565,
0.0025355310644954443,
0.00030956207774579525,
-0.016765793785452843,
-0.044937051832675934,
0.024121491238474846,
0.037569545209407806,
0.06399337947368622,
0.01135233137756586,
-0.0009179862681776285,
0.024180525913834572,
0.05029738321900368,
0.020154373720288277,
-0.024145103991031647,
0.0025606208946555853,
-0.00408223457634449,
-0.08552916347980499,
0.008636745624244213,
-0.01837153173983097,
-0.0143217658624053,
0.04640110582113266,
-0.018182622268795967,
-0.039742015302181244,
0.019623063504695892,
0.006310786586254835,
0.038065437227487564,
-0.07287216931581497,
-0.010602593421936035,
-0.0070723313838243484,
-0.014746814034879208,
-0.016163641586899757,
-0.008223503828048706,
-0.05275321751832962,
-0.04172557592391968,
0.029942290857434273,
-0.009593104012310505,
0.04463006928563118,
0.0020234070252627134,
0.04059211164712906,
-0.0063934349454939365,
0.01911536604166031,
0.024227753281593323,
-0.0015171862905845046,
-0.012149296700954437,
0.0072730486281216145,
0.030603477731347084,
-0.01637616567313671,
-0.029446400701999664,
0.00401434488594532,
0.010331034660339355,
-0.005667310673743486,
0.005354427732527256,
-0.04165473207831383,
0.007733517792075872,
0.007656772620975971,
0.007314372807741165,
0.017474208027124405,
-0.013200110755860806,
0.010118510574102402,
-0.027037793770432472,
-0.009327448904514313,
-0.0030993104446679354,
-0.05317826569080353,
-0.030154814943671227,
-0.02383812516927719,
0.023531146347522736,
-0.024841710925102234,
-0.02857269160449505,
0.051619753241539,
-0.024369435384869576,
0.05020292475819588,
-0.019882814958691597,
0.03216198831796646,
0.014605131931602955,
0.002734772628173232,
0.00415012426674366,
-0.016931090503931046,
0.004380358848720789,
0.05544519051909447,
-0.0017798896878957748,
-0.0063639176078140736,
0.008796138688921928,
0.0314771868288517,
-0.003311834530904889,
0.002643269021064043,
0.027769822627305984,
-0.05497291311621666,
0.013270952738821507,
-0.037451475858688354,
-0.02238587662577629,
-0.010980414226651192,
-0.013459863141179085,
0.01812358759343624,
0.012290979735553265,
-0.04368551820516586,
-0.0009467655327171087,
-0.001034579356200993,
-0.006115972530096769,
-0.030721547082066536,
0.030603477731347084,
-0.036908362060785294,
0.06720485538244247,
0.009599007666110992,
-0.012290979735553265,
0.007202207110822201,
0.02253936603665352,
-0.0741945430636406,
0.04873887076973915,
-0.015998344868421555,
0.03553875908255577,
0.020508579909801483,
-0.048337437212467194,
-0.00022672931663691998,
0.01571498066186905,
-0.014888497069478035,
-0.03532623499631882,
0.04758179560303688,
0.014534289948642254,
0.0023923725821077824,
0.0215003602206707,
-0.0374278649687767,
0.031241049990057945,
0.011700634844601154,
0.0049766069278120995,
0.054122816771268845,
-0.014746814034879208,
-0.02344849705696106,
-0.006257655564695597,
0.009067696519196033,
0.018631283193826675,
0.03539707884192467,
-0.05223371088504791,
-0.005935917608439922,
0.031193822622299194,
0.0805230364203453,
0.005803090054541826,
-0.0006929172668606043,
0.002839558757841587,
-0.04182003065943718,
0.003990731202065945,
-0.01864309050142765,
0.00076892419019714,
0.02283453941345215,
-0.03199668973684311,
0.030131202191114426,
0.02524314634501934,
0.005623034667223692,
0.0037368829362094402,
0.0401906780898571,
0.023354042321443558,
-0.026140470057725906,
-0.030178429558873177,
-0.028218483552336693,
0.00629307609051466,
0.05601191893219948,
0.011635697446763515,
0.01684844307601452,
-0.038655780255794525,
0.00207506213337183,
-0.013223724439740181,
-0.03256342187523842,
0.00615139352157712,
-0.029517242684960365,
-0.046117741614580154,
0.03884468972682953,
0.01832430437207222,
0.08439569920301437,
0.023578373715281487,
0.03598742187023163,
-0.019930042326450348,
-0.017840221524238586,
-0.0010500758653506637,
-0.05539796128869057,
0.010189352557063103,
0.01144088339060545,
0.019198015332221985,
-0.005537434946745634,
0.003553875954821706,
-0.022763697430491447,
-0.020201601088047028,
0.011865931563079357,
0.042693741619586945,
-0.021830951794981956,
0.05053351819515228,
0.011647503823041916,
-0.02975338138639927,
0.06569357216358185,
-0.01491211075335741,
0.037451475858688354,
0.03591658174991608,
-0.012834097258746624,
0.02814764343202114,
-0.05450063571333885,
0.00834747590124607,
-0.018182622268795967,
0.044842593371868134,
0.027651753276586533,
0.011865931563079357,
-0.04592882841825485,
0.013707807287573814,
0.04122968390583992,
-0.002874979516491294,
-0.03034372627735138,
-0.013601545244455338,
0.03782929852604866,
-0.028950512409210205,
-0.026093242689967155,
-0.06342665106058121,
0.01116932462900877,
-0.027911504730582237,
-0.007698096800595522,
0.012208331376314163,
-0.03679029271006584,
-0.009368772618472576,
-0.003580441465601325,
0.03379134088754654,
0.02122880145907402,
-0.046613629907369614,
0.017001932486891747,
-0.023082483559846878,
-0.027958732098340988,
0.00985285546630621,
0.0008899448439478874,
-0.059317849576473236,
0.01541980728507042,
0.009734787046909332,
-0.05851498246192932,
0.0016795310657471418,
0.03322460874915123,
0.04765263572335243,
-0.03258703649044037,
-0.011606180109083652,
-0.031760554760694504,
-0.006092358846217394,
0.04651917517185211,
0.03546791896224022,
0.012125683017075062,
0.005059255287051201,
-0.009935503825545311,
0.009362868964672089,
0.020508579909801483,
-0.0400489941239357,
0.01918620802462101,
0.026754429563879967,
0.06621307879686356,
0.009244800545275211,
0.00660595903173089,
0.016659531742334366,
0.006375724449753761,
0.00038261726149357855,
-0.006523310672491789,
0.0007087828125804663,
-0.03591658174991608,
0.057050928473472595,
0.05379222333431244,
0.019623063504695892,
-0.006836193613708019,
-0.008648552000522614,
0.006228138227015734,
-0.002271351870149374,
0.0023008689749985933,
0.028171256184577942,
-0.01062620710581541,
-0.02386173978447914,
-0.04217423498630524,
0.029399173334240913,
0.031666096299886703,
0.01521909050643444,
0.019788360223174095,
0.005345572717487812,
0.013247338123619556,
0.03830157592892647,
0.014876690693199635,
0.04413418099284172,
0.006676800083369017,
-0.03027288429439068,
0.04111161455512047,
0.01719084195792675,
-0.002600469160825014,
-0.041607506573200226,
0.013282759115099907,
0.03190223500132561,
-0.018194427713751793,
-0.02866714634001255,
-0.03735702112317085,
-0.052375394850969315,
-0.01800551824271679,
0.010437296703457832,
0.008920110762119293,
-0.004660772625356913,
-0.0215239729732275,
0.00971707608550787,
0.02181914635002613,
0.013566125184297562,
0.014487062580883503,
-0.02526675909757614,
-0.04087547957897186,
-0.04800684377551079,
-0.010018152184784412,
0.007066427730023861,
-0.021901793777942657,
0.022515753284096718,
0.032846786081790924,
0.01061440072953701,
-0.02529037371277809,
-0.018536828458309174,
0.03088684193789959,
-0.05228094011545181,
-0.029422787949442863,
0.019965462386608124,
-0.015667753294110298,
0.018761159852147102,
0.015596911311149597,
0.006245848722755909,
0.03315376862883568,
0.007910621352493763,
-0.004465959034860134,
-0.017249876633286476,
-0.00870758667588234,
0.01945776678621769,
-0.035798512399196625,
0.016458814963698387,
0.007526896893978119,
0.023330429568886757,
-0.054122816771268845,
0.001542275887914002,
-0.022173352539539337,
-0.011553049087524414,
-0.013672387227416039,
-0.019906427711248398,
-0.017615890130400658,
0.012231945060193539,
-0.03395663574337959,
0.004764082841575146,
0.030816001817584038,
-0.009782014414668083,
0.016765793785452843,
-0.03093407116830349,
0.0430007204413414,
-0.021889986470341682,
0.008022786118090153,
-0.01972932554781437,
-0.019009103998541832,
0.016447007656097412,
0.04826659709215164,
-0.0018802483100444078,
0.005006124265491962,
-0.02866714634001255,
-0.0007043551886454225,
-0.02299983613193035,
0.004952993243932724,
-0.03308292478322983,
0.04115884378552437,
-0.006529213860630989,
0.026234924793243408,
-0.026683587580919266,
-0.011836414225399494,
-0.029446400701999664,
0.01057897973805666,
0.02751006931066513,
0.009244800545275211,
0.020603034645318985,
-0.008046400733292103,
-0.00743244169279933,
0.043236855417490005,
0.020756525918841362,
-0.014487062580883503,
-0.03029649704694748,
0.013459863141179085,
0.03220921382308006,
-0.03327183425426483,
-0.021760111674666405,
-0.02340126968920231,
0.002306772628799081,
0.034098319709300995,
-0.003713269019499421,
-0.0036571864038705826,
0.006322593428194523,
0.01459332462400198,
0.0516669824719429,
0.02376728318631649,
0.00992369744926691,
-0.01975293830037117,
0.024074263870716095,
0.03499564155936241,
-0.04940005764365196,
-0.025313986465334892,
0.03036733902990818,
-0.02349572442471981,
-0.04460645839571953,
0.0021975587587803602,
0.01348347682505846,
-0.00543117243796587,
0.021441325545310974,
-0.024794483557343483,
-0.005516772624105215,
0.02226780727505684,
-0.008087724447250366,
-0.016187256202101707,
0.023011641576886177,
-0.004722758661955595,
-0.010195255279541016,
0.018678510561585426,
-0.00615729670971632,
-0.0200717244297266,
0.007202207110822201,
0.011128000915050507,
-0.0157858207821846,
0.02285815216600895,
-0.00027469484484754503,
0.026140470057725906,
0.0025930898264050484,
-0.02758091129362583,
0.02356656640768051,
0.023649215698242188,
-0.005032689776271582,
-0.0032203311566263437,
0.016423393040895462,
-0.003444662317633629,
-0.030556250363588333,
-0.06342665106058121,
0.013684193603694439,
0.008837462402880192,
0.0023879448417574167,
-0.03398025035858154,
-0.001065572490915656,
0.003975972533226013,
0.014097435399889946,
0.07877561450004578,
-0.027911504730582237,
0.027651753276586533,
0.0012116828002035618,
-0.01459332462400198,
-0.0035981519613415003,
0.01464055199176073,
-0.0035981519613415003,
-0.016199063509702682,
0.031760554760694504,
-0.02379089780151844,
0.07688651233911514,
0.008241213858127594,
0.016458814963698387,
-0.025550125166773796,
-0.001806455198675394,
-0.004250483121722937,
0.009392386302351952,
-0.007497379556298256,
-0.024794483557343483,
0.003370869206264615,
-0.006971972528845072,
-0.00756822107359767,
-0.015254511497914791,
-0.0002425948332529515,
0.008595420978963375,
0.020201601088047028,
0.02002449706196785,
0.014463448897004128,
-0.010880055837333202,
0.00976430345326662,
-0.017863836139440536,
-0.01841875910758972,
-0.010336938314139843,
0.014770428650081158,
0.0009113448904827237,
0.027368387207388878,
0.018831999972462654,
-0.025337601080536842,
-0.02181914635002613,
-0.022551173344254494,
0.0228817667812109,
-0.015679558739066124,
0.06422951817512512,
-0.0018551587127149105,
-0.004867393523454666,
-0.00760954525321722,
-0.001172572490759194,
-0.025620967149734497,
0.02194902114570141,
-0.011311007663607597,
0.008884689770638943,
0.0008264827774837613,
-0.04703867807984352,
-0.004905765876173973,
-0.02100447006523609,
0.02029605582356453,
-0.006724027916789055,
0.03029649704694748,
0.015596911311149597,
0.004811310674995184,
-0.0009408621117472649,
-0.0008139379788190126,
-0.04193810001015663,
-0.03388579562306404,
0.004206207115203142,
0.0341455452144146,
-0.031217435374855995,
0.056389741599559784,
-0.010502235032618046,
-0.01235001441091299,
0.004185544792562723,
-0.021583007648587227,
-0.02857269160449505,
-0.02812402881681919,
-0.017037352547049522,
0.015821242704987526,
-0.01376684196293354,
0.011145710945129395,
0.009120827540755272,
0.008512772619724274,
0.04470091313123703,
-0.031666096299886703,
-0.04654278978705406,
-0.005823751911520958,
-0.02374367043375969,
0.022645628079771996,
0.018950069323182106,
-0.00688342098146677,
-0.021583007648587227,
-0.031713325530290604,
0.022055283188819885,
0.007639062590897083,
0.007308469153940678,
-0.006535117514431477,
-0.02285815216600895,
-0.05516182258725166,
0.00701920036226511,
0.021075312048196793,
-0.01807636022567749,
-0.03220921382308006,
0.0016869104001671076,
-0.008713490329682827,
-0.011629793792963028,
-0.009179862216114998,
-0.04869164526462555,
0.03135911747813225,
-0.00029295863350853324,
0.011092579923570156,
-0.012326400727033615,
0.00380477262660861,
0.005023834761232138,
-0.024959780275821686,
0.03041456639766693,
0.01029561460018158,
-0.010815117508172989,
0.017297104001045227,
-0.013837683014571667,
-0.001339344889856875,
-0.01076198648661375,
0.003240993246436119,
0.0049884142354130745,
-0.023212360218167305,
-0.025927945971488953,
0.03322460874915123,
-0.010732469148933887,
-0.005764717701822519,
0.01348347682505846,
0.017497820779681206,
-0.028171256184577942,
-0.028997739776968956,
-0.005475448444485664,
0.03490118682384491,
-0.027982346713542938,
0.024511117488145828,
0.0011888069566339254,
0.02283453941345215,
0.019693903625011444,
-0.0741000846028328,
-0.022551173344254494,
-0.03320099413394928,
-0.0030550346709787846,
-0.007231724448502064,
0.020544001832604408,
-0.015301738865673542,
-0.011771476827561855,
0.005876882933080196,
0.0002966483007185161,
0.01466416660696268,
-0.04250482842326164,
-0.01344805583357811,
0.028360167518258095,
-0.014510676264762878,
0.0314771868288517,
-0.0066118622198700905,
0.009073600172996521,
0.007137269247323275,
0.010714759118855,
-0.025313986465334892,
0.008058207109570503,
-0.0007323966128751636,
0.05492568388581276,
-0.011216551996767521,
-0.002907448448240757,
-0.002176896668970585,
-0.0068125794641673565,
-0.001942234579473734,
0.012845903635025024,
0.024251366034150124,
-0.0006239206995815039,
-0.0072730486281216145,
0.00965213868767023,
-0.012928551994264126,
-0.06498516350984573,
0.014439835213124752,
-0.005115338135510683,
0.012184717692434788,
0.003382676048204303,
0.01158846914768219,
0.028431007638573647,
-0.000532786245457828,
-0.01691928319633007,
-0.009280221536755562,
-0.008477352559566498,
-0.05209203064441681,
-0.023141518235206604,
-0.022031670436263084,
-0.003928745165467262,
0.019906427711248398,
-0.014723200350999832,
-0.00965213868767023,
0.010360551998019218,
-0.012279173359274864,
-0.04238675907254219,
0.00543117243796587,
0.010844634845852852,
-0.017922868952155113,
-0.01462874561548233,
-0.003347255289554596,
0.053556084632873535,
0.026659972965717316,
-0.016931090503931046,
-0.007898814044892788,
-0.012975780293345451,
-0.05331994593143463,
0.022622015327215195,
-0.022256001830101013,
0.03967117518186569,
-0.02521953172981739,
0.0012507931096479297,
-0.02814764343202114,
0.029021352529525757,
-0.018725737929344177,
0.01093318685889244,
-0.012468083761632442,
-0.01550245564430952,
0.019788360223174095,
-0.009292027913033962,
0.00956949032843113,
-0.020709296688437462,
-0.02526675909757614,
0.009587200358510017,
0.007137269247323275,
-0.012704221531748772,
-0.003515503602102399,
0.025597352534532547,
0.012338207103312016,
-0.010732469148933887,
-0.018796579912304878,
-0.019953656941652298,
0.0027554347179830074,
-0.010419586673378944,
-0.009469131007790565,
-0.039812855422496796,
-0.015868470072746277,
-0.03381495177745819,
0.02261020801961422,
-0.03329544886946678,
0.030721547082066536,
-0.012373628094792366,
0.013566125184297562,
0.007585931569337845,
-0.005115338135510683,
-0.029942290857434273,
0.027628138661384583,
-0.015868470072746277,
0.014971145428717136,
-0.05346162989735603,
0.029540857300162315,
-0.015608717687427998,
0.028218483552336693,
-0.007426538038998842,
0.014534289948642254,
0.023578373715281487,
0.033035699278116226,
-0.012060745619237423,
0.02640022151172161,
0.008849269710481167,
0.07334444671869278,
0.027061408385634422,
-0.0005597207345999777,
-0.006346207112073898,
-0.015372579917311668,
0.0034210484009236097,
0.026116855442523956,
-0.011617986485362053,
-0.020626649260520935,
0.036459699273109436,
-0.003571586450561881,
0.02184275910258293,
-0.018513213843107224,
0.011234262958168983,
0.00494413822889328,
0.0402379035949707,
0.030485408380627632,
0.0200481116771698,
-0.01918620802462101,
0.012869518250226974,
-0.014014787040650845,
-0.013034814037382603,
-0.01938692480325699,
0.0030875036027282476,
0.020921820774674416,
-0.009687558747828007,
-0.018229849636554718,
0.0061632003635168076,
0.0018905793549492955,
0.03853771090507507,
-0.012090262956917286,
0.034098319709300995,
0.01321191806346178,
0.04134775325655937,
0.01726168394088745,
0.04689699411392212,
0.0064111449755728245,
-0.03322460874915123,
-0.042764581739902496,
0.012001710943877697,
-0.0024602622725069523,
0.06333219259977341,
-0.03199668973684311,
-0.026164084672927856,
0.026022400707006454,
-0.014510676264762878,
-0.009575393982231617,
0.010844634845852852,
0.011812800541520119,
-0.003273462178185582,
0.0009954690467566252,
-0.03837241604924202,
0.015478841960430145,
0.005826703738421202,
-0.04694422334432602,
-0.02011895179748535,
0.018064552918076515,
0.00815266277641058,
0.031170208007097244,
0.0372389517724514,
0.009156248532235622,
-0.012916745617985725,
-0.001368862111121416,
0.03964756056666374,
0.021063504740595818,
-0.010083090513944626,
-0.004613545257598162,
-0.02236226387321949,
0.01603376679122448,
-0.026636360213160515,
-0.0041648829355835915,
-0.005938869435340166,
0.0371444970369339,
0.0371444970369339,
0.022456718608736992,
-0.025904331356287003,
-0.026683587580919266,
0.029871448874473572,
-0.029021352529525757,
-0.04514957591891289,
-0.01768673211336136,
0.05431172624230385,
0.058042705059051514,
-0.007337986491620541,
-0.007810262497514486,
0.02701418101787567,
0.009044082835316658,
-0.03598742187023163,
-0.033484358340501785,
0.027392001822590828,
0.03792375326156616,
0.024888938292860985,
-0.04085186496376991,
-0.0045368000864982605,
0.016175448894500732,
0.008731200359761715,
-0.012420855462551117,
0.021653849631547928,
-0.0570981539785862,
0.0015629379777237773,
-0.05563409999012947,
-0.03449975326657295,
-0.004088138230144978,
-0.03034372627735138,
-0.014333573170006275,
-0.01771034486591816,
0.04883332550525665,
0.0027259173803031445,
-0.032894015312194824,
0.015089214779436588,
-0.005076965782791376,
0.048408277332782745,
0.015124634839594364,
-0.017875641584396362,
-0.02226780727505684,
-0.009114924818277359,
0.005478400271385908,
-0.012538924813270569,
-0.00861903466284275,
0.004961848724633455,
0.04288265109062195,
-0.004291807301342487,
-0.02320055291056633,
-0.021783724427223206,
-0.023117903620004654,
0.004451200366020203,
0.023306814953684807,
-0.0572870634496212,
-0.003975972533226013,
0.026730814948678017,
-0.0036188140511512756,
-0.006859807297587395,
0.0186194758862257,
0.039340581744909286,
0.0315244160592556,
-0.0014817655319347978,
-0.015266317874193192,
-0.014711393974721432,
0.020461352542042732,
0.03206753358244896,
-0.0229526087641716,
-0.0022182208485901356,
-0.005537434946745634,
-0.033035699278116226,
0.006006759125739336,
0.004173737950623035,
0.0028277519159018993,
-0.027179477736353874,
0.0035981519613415003,
0.02367282845079899,
0.0129403593018651,
-0.004253434482961893,
-0.03657776862382889,
0.008034593425691128,
0.02913942188024521,
-0.017131807282567024,
0.043331313878297806,
0.023649215698242188,
0.014841269701719284,
-0.005611227825284004,
0.0025252001360058784,
-0.0005726345116272569,
0.008406510576605797,
0.00200717244297266,
0.01610460691154003,
0.0007442034548148513,
-0.02923387661576271,
-0.019339697435498238,
-0.00507991760969162,
-0.03265787661075592,
-0.020083531737327576,
0.003958262037485838,
-0.01941053941845894,
0.035160940140485764,
-0.007857490330934525,
-0.004713903646916151,
-0.017332524061203003,
-0.01941053941845894,
0.021169766783714294,
0.003379724221304059,
0.002838082844391465,
-0.005643696989864111,
-0.005876882933080196,
-0.04392165690660477,
0.023011641576886177,
0.0023466208949685097,
-0.017131807282567024,
-0.03558598831295967,
0.0315244160592556,
-0.02458195947110653,
-0.03532623499631882,
0.02184275910258293,
-0.025998787954449654,
0.008205793797969818,
0.004341986496001482,
-0.012090262956917286,
-0.011098483577370644,
0.006700414232909679,
-0.006889324635267258,
-0.02231503464281559,
0.0029900965746492147,
-0.017745766788721085,
0.010508138686418533,
0.0026595036033540964,
-0.03435806930065155,
0.009604910388588905,
0.00043685518903657794,
0.0059418207965791225,
-0.005000221077352762,
-0.006523310672491789,
-0.0034564691595733166,
0.004274096805602312,
-0.031217435374855995,
-0.002280206885188818,
0.03244535252451897,
0.026778042316436768,
0.012397241778671741,
0.012054841965436935,
0.013188304379582405,
-0.031146595254540443,
-0.012255558744072914,
-0.01864309050142765,
-0.014510676264762878,
0.004888055380433798,
0.0028808829374611378,
0.00123603455722332,
-0.011057158932089806,
-0.013200110755860806,
-0.023578373715281487,
-0.006098262500017881,
0.07702820003032684,
-0.01837153173983097,
-0.0316188707947731,
0.031335506588220596,
0.014876690693199635,
-0.009008662775158882,
-0.016246290877461433,
0.03159525617957115,
0.005121241789311171,
0.014935724437236786,
-0.007580027915537357,
0.044346705079078674,
0.009557683020830154,
-0.006729931570589542,
0.01601015217602253,
0.02127602882683277,
-0.005572855472564697,
0.0009120827890001237,
0.019516801461577415,
0.02467641420662403,
0.027817049995064735,
0.003208524314686656,
-0.0015127586666494608,
0.005000221077352762,
0.009994538500905037,
0.015065601095557213,
0.022185159847140312,
0.007367503829300404,
0.01380226295441389,
0.04854996129870415,
0.01694289781153202,
0.0065941521897912025,
-0.01825346238911152,
-0.023318622261285782,
-0.004840828012675047,
-0.038018207997083664,
-0.019363312050700188,
-0.017875641584396362,
0.015526069328188896,
-0.03197307884693146,
-0.025597352534532547,
-0.005020882934331894,
0.01827707700431347,
0.02812402881681919,
-0.02118157409131527,
-0.0017120001139119267,
0.02455834671854973,
0.021122539415955544,
0.03667222335934639,
0.004826069343835115,
0.002348096575587988,
-0.013684193603694439,
-0.005156662315130234,
-0.016753986477851868,
-0.0032498484943062067,
0.01102173887193203,
-0.003040276002138853,
0.01857224851846695,
0.0229762215167284,
0.004253434482961893,
-0.027203090488910675,
-0.0015880276914685965,
-0.058042705059051514,
0.026022400707006454,
-0.017698539420962334,
-0.030556250363588333,
-0.014368994161486626,
-0.025054235011339188,
-0.027061408385634422,
-0.034098319709300995,
-0.0051684691570699215,
0.02746284194290638,
-0.014191890135407448,
-0.012373628094792366,
-0.0057912832126021385,
-0.0026314621791243553,
-0.0008825655677355826,
0.01750962808728218,
-0.025384828448295593,
0.01290493831038475,
0.004398069344460964,
-0.005363283213227987,
0.02226780727505684,
0.021098924800753593,
-0.027061408385634422,
0.012928551994264126,
0.0014935724902898073,
0.025030622258782387,
-0.029068579897284508,
-0.005038593430072069,
0.0014124000445008278,
-0.03657776862382889,
0.04973065108060837,
-0.00729666231200099,
-0.005637793336063623,
-0.004651917610317469,
-0.010962704196572304,
0.001505379332229495,
0.02317693829536438,
0.00004662801802624017,
0.004669627640396357,
0.042150624096393585,
-0.030650705099105835,
-0.03669583797454834,
-0.005254069343209267,
0.01371961459517479,
-0.03565682843327522,
0.0024189380928874016,
0.010106704197824001,
0.01464055199176073,
-0.006558731198310852,
-0.009823338128626347,
-0.00971707608550787,
0.039883699268102646,
-0.003739834763109684,
0.01837153173983097,
0.005820800084620714,
-0.033531587570905685,
-0.044441159814596176,
-0.009179862216114998,
0.013341793790459633,
0.013554317876696587,
0.02100447006523609,
0.013518896885216236,
0.005304248537868261,
-0.03225644305348396,
-0.005924110766500235,
0.016541462391614914,
0.012338207103312016,
0.03388579562306404,
-0.006588248535990715,
0.030532635748386383,
-0.00670631742104888,
-0.01550245564430952,
0.012184717692434788,
0.04479536786675453,
0.012279173359274864,
-0.012527117505669594,
-0.0019820828456431627,
0.026069628074765205,
-0.005682069342583418,
0.008996855467557907,
-0.009599007666110992,
0.015065601095557213,
0.017934676259756088,
0.016411587595939636,
-0.030650705099105835,
-0.047298431396484375,
0.006180910859256983,
0.01290493831038475,
-0.013329986482858658,
-0.0078811040148139,
0.0018832001369446516,
-0.01464055199176073,
-0.01289313193410635,
-0.007326179649680853,
-0.04139498248696327,
-0.04066295176744461,
-0.015077407471835613,
0.015726786106824875,
-0.03624717518687248,
-0.0024646897800266743,
-0.004926427733153105,
0.02034328319132328,
0.0143217658624053,
-0.01317649707198143,
-0.002876455197110772,
0.0258098766207695,
-0.007054620888084173,
0.012007614597678185,
0.02184275910258293,
0.01144088339060545,
0.016482427716255188,
-0.04368551820516586,
-0.029044967144727707,
0.009628525003790855,
-0.006234041880816221,
0.03589296713471413,
-0.036341629922389984,
0.025597352534532547,
0.01750962808728218,
-0.04481898248195648,
0.02027244307100773,
-0.009776110760867596,
-0.009965021163225174,
0.03199668973684311,
-0.010673435404896736,
-0.012692414224147797,
-0.013259145431220531,
-0.0057794759050011635,
-0.009970924817025661,
0.020189793780446053,
0.019375117495656013,
0.013554317876696587,
-0.0014788138214498758,
0.026801656931638718,
0.06267101317644119,
-0.025526512414216995,
-0.03331906348466873,
0.029044967144727707,
0.03395663574337959,
-0.007178593426942825,
-0.001869917381554842,
0.03327183425426483,
0.011446787044405937,
-0.06012072041630745,
-0.007798455655574799,
0.00587983475998044,
-0.004061572719365358,
-0.015537876635789871,
-0.006623669061809778,
-0.005301296710968018,
0.031099366024136543,
0.010083090513944626,
-0.024487504735589027,
-0.0017990759806707501,
-0.017580470070242882,
0.010283807292580605,
-0.009693462401628494,
0.0185958631336689,
-0.042056165635585785,
-0.005667310673743486,
0.0011319862678647041,
-0.032988470047712326,
-0.015289931558072567,
0.031736940145492554,
0.0054075587540864944,
-0.015585104003548622,
-0.007031007204204798,
-0.026754429563879967,
-0.027273932471871376,
-0.024274980649352074,
-0.022102510556578636,
0.010130317881703377,
0.005301296710968018,
0.0066413795575499535,
-0.05950676277279854,
-0.033012084662914276,
0.014144662767648697,
-0.009528165683150291,
-0.05553964525461197,
0.0017813656013458967,
-0.007267144974321127,
-0.01975293830037117,
0.021653849631547928,
0.03702642768621445,
-0.020189793780446053,
-0.0015334207564592361,
-0.04649556055665016,
0.00801688339561224,
-0.031831394881010056,
0.01911536604166031,
-0.006340303923934698,
-0.005422317422926426,
-0.014735007658600807,
0.020130759105086327,
-0.014451641589403152,
-0.015596911311149597,
-0.03272872045636177,
0.01405020710080862,
-0.02467641420662403,
-0.01834791898727417,
0.020732911303639412,
0.014345379546284676,
-0.008766621351242065,
0.002311200136318803,
-0.014404414221644402,
-0.026541905477643013,
-0.0005423793336376548,
0.04680253937840462,
-0.011234262958168983,
0.01980016566812992,
-0.0017548000905662775,
0.006600055377930403,
-0.006800772622227669,
0.006322593428194523,
-0.011558951810002327,
-0.01015983521938324,
0.025502897799015045,
-0.00387561391107738,
0.0017784138908609748,
0.00985285546630621,
-0.010826924815773964,
-0.018513213843107224,
-0.017297104001045227,
-0.013636966235935688,
-0.016458814963698387,
0.017875641584396362,
-0.02918664924800396,
0.006027420982718468,
-0.033484358340501785,
0.0051684691570699215,
-0.012763256207108498,
-0.0021783725824207067,
-0.009776110760867596,
0.0459996722638607,
0.008075918070971966,
-0.019363312050700188,
0.005056303460150957,
0.004696193151175976,
-0.010236579924821854,
0.02000088430941105,
-0.015632331371307373,
0.005174372810870409,
0.027722595259547234,
-0.014935724437236786,
-0.01982378028333187,
0.01043139398097992,
-0.024298593401908875,
-0.02179553173482418,
0.0027185380458831787,
-0.012491697445511818,
0.012881324626505375,
0.052422624081373215,
0.01541980728507042,
-0.007780745159834623,
0.012727835215628147,
0.007031007204204798,
-0.0258807186037302,
-0.0006412621005438268,
-0.023708248510956764,
-0.020603034645318985,
-0.004274096805602312,
-0.0017518483800813556,
0.08193986862897873,
-0.0056289383210241795,
-0.024345822632312775,
0.005236358847469091,
-0.023897159844636917,
-0.014392607845366001,
0.024180525913834572,
-0.01435718685388565,
-0.013696000911295414,
0.0037014621775597334,
0.015301738865673542,
0.019871007651090622,
0.025054235011339188,
0.007946041412651539,
-0.007267144974321127,
-0.016364360228180885,
0.03877384960651398,
0.029895063489675522,
0.02179553173482418,
0.008223503828048706,
-0.015207283198833466,
0.025337601080536842,
-0.012113876640796661,
0.021335063502192497,
-0.02270466275513172,
-0.02760452590882778,
-0.01380226295441389,
-0.001976179424673319,
-0.025668194517493248,
-0.015903890132904053,
0.014368994161486626,
0.0014124000445008278,
0.01235001441091299,
-0.01015983521938324,
0.0031819588039070368,
0.009227090515196323,
-0.02916303649544716,
-0.018796579912304878,
-0.004350841511040926,
0.014180083759129047,
-0.02743922919034958,
-0.006659090053290129,
-0.024912552908062935,
0.0027259173803031445,
0.010514041408896446,
-0.031146595254540443,
-0.03539707884192467,
-0.0037988692056387663,
0.014947531744837761,
0.004542703740298748,
-0.026140470057725906,
-0.0025178208015859127,
0.008937820792198181,
0.015833048149943352,
-0.018926456570625305,
-0.008872883394360542,
0.006576441694051027,
0.000225253461394459,
-0.0035332138650119305,
-0.029446400701999664,
-0.033460747450590134,
0.00018208449182566255,
0.014711393974721432,
0.016565077006816864,
-0.011706538498401642
] | 2024-07-10 | 28 | 38983927 | [
"CD19 CART treatment",
"CD19 CART treatment failure",
"non-CART therapy",
"subsequent anti-cancer salvage therapy",
"CD20",
"improved overall survival",
"overall survival",
"CD19CART treatment failure",
"CD20CART therapy",
"CD20CART treatment",
"Patients",
"patients",
"Beijing Gobroad Boren Hospital",
"CD19-specific chimeric antigen receptor T-cell therapy",
"the non-CART group",
"B-cell lymphoma",
"relapsed or refractory aggressive B-cell lymphoma",
"CD20-SD-CART therapy",
"progression-free survival",
"CD20-SD-CART",
"CD19CART",
"CAR T-cells",
"the CD20-SD-CART group",
"Multivariate analysis",
"significantly longer median progression-free survival",
"relapsed/refractory aggressive B-cell lymphoma(r/r aBCL)who",
"CI",
"CD20CART",
"a salvage therapy",
"the survival outcome"
] | [
"B-cell lymphoma",
"CART treatment failure",
"CD19",
"CD20CART",
"salvage therapy"
] | 0 | 10.3389/fonc.2024.1376490
10.1056/NEJMoa1707447
10.1016/S1470-2045(21)00375-2
10.1016/S1470-2045(18)30864-7
10.1002/cam4.3881
10.1182/blood.2022016945
10.1182/blood.2020006245
10.1038/s41375-022-01739-2
10.1002/ajh.25505
10.1200/JCO.20.01467
10.1182/bloodadvances.2021006801
10.1186/s13045-021-01120-3
10.1182/bloodadvances.2022009025
10.1038/sigtrans.2016.2
10.1182/blood-2019-125102
10.1182/blood-2016-01-643569
10.1155/2022/2900310
10.1056/NEJMoa1407222
10.1182/bloodadvances.2021006845
10.1038/leu.2017.145
10.1200/JCO.2013.54.8800
10.1016/j.bbmt.2018.12.758
10.1097/00000421-198212000-00014
10.1056/NEJM199309303291402
10.2147/OTT.S312904
10.1038/s41571-019-0184-6
10.1186/s40164-020-00190-2
10.3389/fimmu.2019.02664
10.1038/s41586-019-1054-1 | [
"Xue",
"Zheng",
"Yang",
"Liu",
"Feng",
"Guo",
"Shi",
"Ma",
"Deng",
"Xu",
"Zhang",
"Zhou",
"Ke",
"Hu"
] | [
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Cytology Laboratory, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Hospital Management, Gobroad Medical Group, Beijing, China.",
"Clinical Research Centre, GoBroad Healthcare Group, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China.",
"Department of Lymphoma and Myeloma Research Center, Beijing Gobroad Boren Hospital, Beijing, China."
] | [
"38983927",
"29226797",
"34516954",
"30518502",
"33932100",
"36122385",
"33156925",
"36335261",
"31056762",
"33021872",
"35240681",
"34225766",
"36417762",
"29263894",
"26980727",
"36483984",
"25317870",
"35901280",
"28490811",
"25113753",
"30592986",
"7165009",
"8141877",
"34239307",
"30837712",
"33292660",
"31798590",
"30918399"
] | [] | 6.562453 | 5.573269 |
38982561 | 744 | IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma. | Chimeric antigen receptor (CAR)-T cell therapies targeting glioblastoma (GBM)-associated antigens such as interleukin-13 receptor subunit alpha-2 (IL-13Rα2) have achieved limited clinical efficacy to date, in part due to an immunosuppressive tumor microenvironment (TME) characterized by inhibitory molecules such as transforming growth factor-beta (TGF-β). The aim of this study was to engineer more potent GBM-targeting CAR-T cells by countering TGF-β-mediated immune suppression in the TME.
We engineered a single-chain, bispecific CAR targeting IL-13Rα2 and TGF-β, which programs tumor-specific T cells to convert TGF-β from an immunosuppressant to an immunostimulant. Bispecific IL-13Rα2/TGF-β CAR-T cells were evaluated for efficacy and safety against both patient-derived GBM xenografts and syngeneic models of murine glioma.
Treatment with IL-13Rα2/TGF-β CAR-T cells leads to greater T-cell infiltration and reduced suppressive myeloid cell presence in the tumor-bearing brain compared to treatment with conventional IL-13Rα2 CAR-T cells, resulting in improved survival in both patient-derived GBM xenografts and syngeneic models of murine glioma.
Our findings demonstrate that by reprogramming tumor-specific T-cell responses to TGF-β, bispecific IL-13Rα2/TGF-β CAR-T cells resist and remodel the immunosuppressive TME to drive potent anti-tumor responses in GBM. | [
0.03507643938064575,
0.03681159019470215,
0.05407526344060898,
0.03503251075744629,
-0.06325619667768478,
-0.018768200650811195,
-0.002995334565639496,
-0.0005209575756452978,
-0.02330375835299492,
-0.02171137183904648,
-0.0027784404810518026,
-0.008878929540514946,
-0.03534000739455223,
-0.003063972108066082,
0.03048597276210785,
-0.04467468708753586,
0.04434522986412048,
-0.02069004811346531,
-0.003599343355745077,
0.034571267664432526,
0.0199542548507452,
0.005235658027231693,
-0.031100962311029434,
0.027432981878519058,
-0.03371467441320419,
-0.0007234378135763109,
0.026532460004091263,
-0.01373845525085926,
-0.012211959809064865,
-0.01031756866723299,
0.01684635505080223,
-0.012640257366001606,
-0.044213443994522095,
-0.06000553071498871,
-0.036767665296792984,
0.020393533632159233,
0.03619660064578056,
0.010372478514909744,
-0.01927337236702442,
-0.00859339814633131,
0.049067478626966476,
0.01616547256708145,
-0.0008442396065220237,
0.0743260309100151,
-0.034856799989938736,
0.004148442298173904,
-0.01337604969739914,
-0.03790979087352753,
0.031825773417949677,
0.00243250816129148,
-0.0026507750153541565,
0.009773961268365383,
-0.027806369587779045,
0.024621596559882164,
-0.008236483670771122,
0.03439555689692497,
-0.019965237006545067,
0.042126867920160294,
-0.04320310428738594,
0.02651049569249153,
-0.00345108681358397,
-0.003599343355745077,
0.03143042325973511,
-0.016341183334589005,
-0.058995187282562256,
-0.030134549364447594,
-0.04924319311976433,
-0.005526680499315262,
0.01614350825548172,
0.010191275738179684,
0.023391613736748695,
-0.04067724943161011,
-0.005628264043480158,
0.01911962404847145,
0.05447061359882355,
0.01656082272529602,
0.003909584134817123,
0.012739094905555248,
0.0046014487743377686,
-0.03411002457141876,
0.005158784333616495,
0.00007151155296014622,
0.008889911696314812,
-0.03421984612941742,
-0.021799227222800255,
-0.008110190741717815,
0.004129223991185427,
-0.04072117805480957,
-0.06444224715232849,
0.008714199997484684,
0.0008586534531787038,
-0.014748796820640564,
-0.036240529268980026,
0.0394911952316761,
0.010850194841623306,
-0.012640257366001606,
0.003582870587706566,
-0.03841496258974075,
0.04210490733385086,
0.06220192462205887,
0.035669464617967606,
-0.023545362055301666,
-0.009016204625368118,
-0.007248105946928263,
0.06158693507313728,
0.005650227889418602,
-0.034966617822647095,
0.001099570537917316,
-0.006704498082399368,
-0.008648307994008064,
0.11280688643455505,
0.012025266885757446,
0.022666804492473602,
0.019449083134531975,
-0.02105245366692543,
-0.040918853133916855,
-0.01943810284137726,
-0.02468748763203621,
-0.03050793707370758,
0.007813678123056889,
-0.04004029184579849,
0.005803975742310286,
0.020986560732126236,
-0.03009062074124813,
-0.00453281169757247,
-0.04704679548740387,
0.07186606526374817,
-0.03437359258532524,
-0.047837499529123306,
-0.04028189554810524,
0.01854856126010418,
-0.0015937596326693892,
0.05051710084080696,
0.018120264634490013,
-0.052230291068553925,
-0.01729661598801613,
-0.05271349847316742,
0.007632474880665541,
-0.05411918833851814,
0.0038848749827593565,
-0.0037695642095059156,
0.004365336615592241,
-0.006984538398683071,
-0.0120801767334342,
-0.041731517761945724,
-0.05780913308262825,
-0.025214621797204018,
0.014364427886903286,
-0.0061004888266325,
0.02940973825752735,
-0.03889816626906395,
0.05288920924067497,
0.025631938129663467,
-0.0010110284201800823,
0.00030766698182560503,
-0.04858427122235298,
-0.01441933773458004,
0.09444501250982285,
-0.01222294196486473,
-0.06655079126358032,
0.00332753942348063,
0.008988749235868454,
-0.03604285418987274,
0.01013636589050293,
0.03709712252020836,
0.03173791617155075,
0.01896587759256363,
0.03217719867825508,
-0.0646618902683258,
-0.026839954778552055,
0.014803706668317318,
0.004181388299912214,
-0.07133892923593521,
-0.013332122005522251,
-0.05794091895222664,
0.0319136306643486,
-0.004678322933614254,
-0.012200977653265,
-0.020031128078699112,
-0.027367090806365013,
-0.019317300990223885,
0.018801147118210793,
0.0038162374403327703,
0.05315277725458145,
-0.0631244108080864,
0.01781276986002922,
-0.024489812552928925,
0.0102901142090559,
-0.010421897284686565,
0.009169952012598515,
0.0049226717092096806,
-0.011289473623037338,
0.058863405138254166,
0.02591746859252453,
0.01864739879965782,
-0.02690584771335125,
0.046871084719896317,
0.005617281887680292,
-0.035801250487565994,
0.01747232861816883,
0.044520940631628036,
-0.0328141525387764,
-0.03962297737598419,
0.007281051948666573,
-0.011201618239283562,
-0.015166112221777439,
0.0030255350284278393,
0.06220192462205887,
-0.053723838180303574,
0.028091900050640106,
0.04700286686420441,
-0.008230992592871189,
-0.01373845525085926,
-0.011596969328820705,
-0.021513696759939194,
0.0074732364155352116,
-0.0205802284181118,
0.01951497606933117,
0.028091900050640106,
0.016286274418234825,
-0.02084379456937313,
-0.02385285682976246,
-0.024050533771514893,
0.029431702569127083,
-0.028245648369193077,
0.010427388362586498,
0.025631938129663467,
0.005073674023151398,
-0.015429680235683918,
-0.011981338262557983,
-0.01099845115095377,
0.00579299358651042,
0.0369873046875,
-0.03716301545500755,
-0.004648122470825911,
-0.005622772965580225,
0.0504731722176075,
-0.0034291227348148823,
0.04405969753861427,
-0.044894326478242874,
0.010767829604446888,
0.041314203292131424,
0.014002022333443165,
-0.04717858135700226,
-0.019690686836838722,
0.0008730672998353839,
-0.009905744343996048,
-0.07415031641721725,
-0.01734054461121559,
0.0007323606987483799,
-0.0199872013181448,
-0.009966145269572735,
-0.01482567097991705,
-0.012739094905555248,
-0.003681708360090852,
0.03700926899909973,
0.01004301942884922,
-0.002786677097901702,
0.0015086493222042918,
-0.01815321110188961,
-0.01331015769392252,
0.008066263049840927,
0.0015127675142139196,
-0.03845888748764992,
-0.03468108922243118,
0.036899447441101074,
0.011201618239283562,
0.004302190151065588,
0.017439382150769234,
-0.0025697830133140087,
0.038151394575834274,
0.011476167477667332,
0.06422261148691177,
-0.022370290011167526,
-0.0513078048825264,
0.0006795099470764399,
-0.004541048314422369,
0.04460879787802696,
-0.015363788232207298,
0.008000371046364307,
-0.025038911029696465,
0.015539499931037426,
0.014803706668317318,
-0.03224308788776398,
-0.02690584771335125,
-0.031013106927275658,
-0.003794273594394326,
0.012508473359048367,
-0.03241879865527153,
-0.03494465723633766,
0.015715211629867554,
-0.004777160473167896,
-0.009197407402098179,
0.004667340777814388,
-0.020206840708851814,
0.019031768664717674,
0.007566583342850208,
-0.007742295041680336,
-0.03336324915289879,
0.027125487104058266,
-0.02034960687160492,
-0.004293953534215689,
-0.024797307327389717,
-0.023435542359948158,
0.013189355842769146,
0.02196395769715309,
-0.010235204361379147,
-0.0022966063115745783,
0.029849017038941383,
0.04621216654777527,
0.02677406370639801,
-0.014682904817163944,
0.016308238729834557,
0.03586714342236519,
0.009889272041618824,
0.002243069000542164,
0.012794004753232002,
-0.03881031274795532,
0.0008902266272343695,
-0.030727576464414597,
-0.03979869186878204,
0.0023309248499572277,
-0.040743138641119,
0.01612154394388199,
-0.006979047320783138,
-0.0067484257742762566,
0.004642631392925978,
-0.0031381002627313137,
0.0099771274253726,
-0.02690584771335125,
0.026554424315690994,
-0.0014509939355775714,
0.042434364557266235,
0.020799867808818817,
0.006726461928337812,
-0.036767665296792984,
-0.02304019033908844,
-0.012750077061355114,
0.010531716980040073,
-0.015836013481020927,
-0.01564931869506836,
0.04124831035733223,
-0.0458168126642704,
0.041028670966625214,
0.015868958085775375,
-0.0023460250813513994,
0.03173791617155075,
0.017757859081029892,
0.04528968036174774,
0.04397184029221535,
0.014045950025320053,
0.01614350825548172,
0.0012986189685761929,
-0.03342914208769798,
-0.009296244941651821,
-0.010685465298593044,
-0.0216235164552927,
-0.007149267941713333,
0.028047973290085793,
0.017593128606677055,
-0.0012334134662523866,
0.036635879427194595,
-0.03259451314806938,
0.02868492715060711,
0.05455847084522247,
0.05754556879401207,
-0.01718679629266262,
0.05244993045926094,
-0.006699007004499435,
-0.020887723192572594,
-0.017044030129909515,
0.013639617711305618,
0.028245648369193077,
0.018460705876350403,
0.024094460532069206,
0.018790164962410927,
0.015627356246113777,
0.04401576891541481,
0.011805626563727856,
0.004472410771995783,
0.037492476403713226,
0.01938319206237793,
-0.015923868864774704,
-0.04168758913874626,
-0.03459323197603226,
0.012343743816018105,
0.04329095780849457,
-0.012618293054401875,
-0.05398740619421005,
0.04647573456168175,
0.006814317777752876,
-0.048364631831645966,
0.021898064762353897,
0.004186879377812147,
-0.009878289885818958,
0.040743138641119,
0.004313171841204166,
0.04234650731086731,
0.0458168126642704,
0.039688870310783386,
-0.009175443090498447,
-0.032221123576164246,
-0.03487876430153847,
-0.06145515292882919,
0.015286914072930813,
-0.005946741439402103,
0.04425737261772156,
0.011981338262557983,
-0.003703672206029296,
-0.024797307327389717,
-0.026444604620337486,
-0.018109282478690147,
0.022864479571580887,
-0.0004461428616195917,
-0.026268891990184784,
-0.014540139585733414,
-0.03492269292473793,
0.041182421147823334,
0.018405795097351074,
0.028333503752946854,
0.035120368003845215,
-0.02883867546916008,
0.022447163239121437,
-0.03171595558524132,
-0.012277851812541485,
-0.003703672206029296,
0.03118881955742836,
0.019756579771637917,
0.022062795236706734,
-0.030002765357494354,
-0.04594859853386879,
0.04985818266868591,
-0.007934479042887688,
-0.05903911590576172,
-0.04190722852945328,
0.04814499244093895,
-0.023150010034441948,
0.00218815915286541,
-0.06571616232395172,
0.05561273917555809,
-0.02246912755072117,
-0.022842515259981155,
0.002934933640062809,
-0.03841496258974075,
0.047398220747709274,
0.002240323694422841,
0.011684824712574482,
0.03819531947374344,
-0.0424782931804657,
-0.02910224348306656,
-0.0164070762693882,
-0.010850194841623306,
0.027652621269226074,
0.026444604620337486,
-0.019811488687992096,
-0.0008716945303604007,
0.0654965192079544,
-0.05451454222202301,
0.0067484257742762566,
-0.0038601653650403023,
0.04897962510585785,
-0.06663864850997925,
-0.0015361042460426688,
-0.038722455501556396,
-0.015319859609007835,
0.004886980634182692,
0.01653886027634144,
-0.004856780171394348,
-0.005710628814995289,
-0.019152570515871048,
-0.03215523436665535,
0.015023346990346909,
-0.04761786013841629,
0.0256539024412632,
-0.00090944510884583,
0.029299918562173843,
-0.002697448479011655,
-0.025016946718096733,
0.040633320808410645,
0.026115145534276962,
0.006517804227769375,
0.0004516338522080332,
-0.0124974912032485,
0.0012828323524445295,
0.01601172424852848,
0.025478189811110497,
-0.02304019033908844,
-0.04950675740838051,
-0.027564765885472298,
0.030046693980693817,
-0.012728112749755383,
-0.025214621797204018,
0.03964494168758392,
-0.008489069528877735,
-0.0026686207856982946,
-0.0007810932002030313,
0.020887723192572594,
-0.04480647295713425,
-0.013540779240429401,
0.031210782006382942,
-0.0033687218092381954,
0.04941890388727188,
0.00410176906734705,
-0.0007131422171369195,
-0.0034153952728956938,
0.01633020117878914,
-0.03929352015256882,
0.027498874813318253,
-0.015748156234622,
0.0033220485784113407,
-0.0012629275443032384,
-0.0028168775606900454,
0.019998183473944664,
-0.004947381094098091,
0.0018339904490858316,
-0.0059412503615021706,
-0.04210490733385086,
-0.007231632713228464,
0.0009979873429983854,
0.005666701123118401,
-0.0012629275443032384,
-0.023830892518162727,
-0.021876100450754166,
-0.002212868770584464,
0.0033769584260880947,
-0.036350347101688385,
-0.045333608984947205,
-0.0028717874083667994,
-0.025895506143569946,
-0.04129223898053169,
0.016385111957788467,
-0.025478189811110497,
0.0004924730747006834,
0.011212600395083427,
-0.030288295820355415,
-0.021041471511125565,
-0.02444588392972946,
0.023786965757608414,
-0.015550481155514717,
-0.058995187282562256,
0.016571804881095886,
0.00042143341852352023,
0.029717233031988144,
0.015111202374100685,
0.01750527322292328,
0.016022706404328346,
0.029277954250574112,
-0.022996263578534126,
0.017131885513663292,
-0.015297896228730679,
0.046168237924575806,
-0.03597696125507355,
0.0588194765150547,
0.002499772934243083,
0.02146976813673973,
-0.02217261493206024,
0.011119253002107143,
-0.02747691050171852,
-0.0005508148460648954,
-0.01572619378566742,
0.0012896960834041238,
-0.022271452471613884,
0.008406704291701317,
-0.03806353732943535,
-0.017076976597309113,
-0.003920566290616989,
-0.01820812001824379,
0.0012945006601512432,
-0.03411002457141876,
0.053767766803503036,
-0.013474887236952782,
0.03852478042244911,
0.013969076797366142,
-0.025170695036649704,
0.0315622054040432,
0.004672831855714321,
-0.028487252071499825,
-0.021348966285586357,
-0.011465185321867466,
0.005595318041741848,
-0.01784571446478367,
-0.02055826410651207,
-0.022260470315814018,
0.035933032631874084,
-0.0082035381346941,
0.017878660932183266,
-0.03944726660847664,
-0.007231632713228464,
0.01843874156475067,
0.009076605550944805,
-0.008955803699791431,
-0.021480750292539597,
0.018405795097351074,
-0.01760411076247692,
-0.027762440964579582,
0.0040880413725972176,
-0.006089507136493921,
-0.0026521477848291397,
-0.03476894274353981,
0.03395627811551094,
-0.004505356773734093,
-0.008955803699791431,
-0.02580764889717102,
-0.019416138529777527,
-0.014957454986870289,
0.03116685524582863,
0.010921577922999859,
-0.01310150045901537,
-0.024863198399543762,
-0.006435439456254244,
0.04854034632444382,
0.05354812741279602,
-0.022326361387968063,
0.004859525710344315,
-0.01083921268582344,
-0.007121813017874956,
-0.006193835753947496,
0.008368267677724361,
0.04441112279891968,
-0.0008991495124064386,
-0.003975476138293743,
-0.021096380427479744,
-0.005167020950466394,
0.01635216549038887,
0.006611151155084372,
-0.031232746317982674,
-0.030683647841215134,
-0.008351794444024563,
0.009856325574219227,
0.01593485102057457,
-0.034703053534030914,
-0.003091427031904459,
-0.01484763529151678,
0.03832710534334183,
-0.001360392547212541,
-0.042302582412958145,
0.031122926622629166,
0.0013198965461924672,
-0.011553041636943817,
-0.029870981350541115,
-0.0050050364807248116,
-0.014529157429933548,
-0.03558161109685898,
-0.05671093612909317,
0.004379063844680786,
0.005897322669625282,
-0.03628445789217949,
0.008126663975417614,
-0.002078339457511902,
0.004513593390583992,
-0.03217719867825508,
-0.033890385180711746,
-0.006336601451039314,
0.0285751074552536,
0.021612534299492836,
-0.005930268205702305,
0.012739094905555248,
-0.019976219162344933,
0.05736985430121422,
0.05218636244535446,
-0.039535123854875565,
0.020415497943758965,
-0.047266434878110886,
-0.013892202638089657,
0.0034373593516647816,
0.021491732448339462,
-0.03459323197603226,
-0.001669260673224926,
-0.0002784961252473295,
-0.0036679808981716633,
0.06523295491933823,
-0.003462068736553192,
0.01367256324738264,
-0.02622496522963047,
0.012431599199771881,
0.04342274367809296,
-0.011009433306753635,
-0.03369271010160446,
-0.023435542359948158,
-0.0069406102411448956,
0.026861919090151787,
0.009554320946335793,
-0.01734054461121559,
-0.08469301462173462,
0.008456123061478138,
0.02000916562974453,
-0.016516895964741707,
-0.02622496522963047,
0.005123092792928219,
-0.026993703097105026,
0.0058588855899870396,
-0.0256539024412632,
-0.021832173690199852,
-0.011739734560251236,
-0.016879301518201828,
-0.009889272041618824,
-0.009351154789328575,
0.025478189811110497,
-0.025302479043602943,
-0.05411918833851814,
0.017065994441509247,
0.024489812552928925,
0.02212868630886078,
-0.03424181044101715,
0.03584517911076546,
-0.024094460532069206,
-0.017834732308983803,
-0.008615362457931042,
0.013321139849722385,
0.020964596420526505,
-0.016440020874142647,
-0.0005693469429388642,
-0.02980509027838707,
-0.03226505219936371,
0.03266040235757828,
-0.009960654191672802,
0.019712651148438454,
0.05394347757101059,
-0.002760594943538308,
0.014573085121810436,
-0.01671457104384899,
-0.0060785249806940556,
-0.014122824184596539,
-0.009082096628844738,
0.046563588082790375,
-0.0007138286018744111,
-0.053723838180303574,
0.041050635278224945,
-0.008351794444024563,
-0.027235306799411774,
0.015901904553174973,
0.011124744080007076,
-0.005449806805700064,
0.0024984001647681,
-0.028487252071499825,
0.031540241092443466,
-0.0218651182949543,
-0.04950675740838051,
0.008785583078861237,
-0.004735978320240974,
0.037734076380729675,
-0.01422166172415018,
-0.04818892106413841,
0.010301095433533192,
-0.004090786911547184,
0.02332572266459465,
0.034285735338926315,
0.0021936502307653427,
0.023567326366901398,
-0.02251305617392063,
0.0074183265678584576,
0.005526680499315262,
-0.006819808855652809,
0.007088867016136646,
0.0068033356219530106,
-0.008209029212594032,
0.001111925346776843,
-0.016527878120541573,
-0.014606031589210033,
-0.028091900050640106,
-0.030002765357494354,
-0.020931651815772057,
-0.006814317777752876,
-0.014671923592686653,
-0.01525396853685379,
-0.0057271015830338,
0.005051710177212954,
-0.00317379180341959,
0.0025189912412315607,
0.02716941386461258,
-0.016319220885634422,
-0.03641624003648758,
0.015792084857821465,
-0.007753276731818914,
-0.0011901719262823462,
0.011465185321867466,
-0.0022142413072288036,
0.023830892518162727,
0.01771393045783043,
0.003917820751667023,
0.005361950956285,
0.013200337998569012,
-0.006473876535892487,
0.015715211629867554,
-0.009334681555628777,
0.01653886027634144,
0.004313171841204166,
0.023633217439055443,
-0.028509216383099556,
-0.0076105110347270966,
-0.020053092390298843,
0.04392791539430618,
-0.02912420779466629,
0.013606671243906021,
-0.02596139721572399,
0.04304935410618782,
0.022556982934474945,
-0.09541142731904984,
-0.025038911029696465,
-0.004447701387107372,
0.010240694507956505,
-0.00854397937655449,
0.009532357566058636,
-0.019503993913531303,
-0.01781276986002922,
0.00021981116151437163,
-0.02217261493206024,
0.00246545416302979,
-0.023677146062254906,
-0.006506822071969509,
0.03132060170173645,
0.024643559008836746,
-0.006232272833585739,
-0.03393431380391121,
-0.0563155859708786,
0.019207481294870377,
0.030134549364447594,
0.02481927163898945,
-0.005853394512087107,
-0.028948495164513588,
0.03979869186878204,
0.023962676525115967,
0.00046501815086230636,
0.006089507136493921,
0.00786309689283371,
-0.03826121240854263,
-0.044916290789842606,
-0.013024626299738884,
-0.00317379180341959,
-0.0224910918623209,
0.03215523436665535,
-0.03738265484571457,
-0.02881671115756035,
0.027432981878519058,
-0.007506182417273521,
0.002395444083958864,
0.03852478042244911,
-0.004845798015594482,
-0.0009478820138610899,
0.04647573456168175,
0.005136820487678051,
-0.03202344849705696,
-0.004796379245817661,
-0.004442210309207439,
0.0038903658278286457,
0.013002662919461727,
-0.02061317302286625,
0.0037613275926560163,
-0.007264578714966774,
-0.02664227969944477,
0.000591654097661376,
-0.0014894307823851705,
-0.05460239574313164,
0.0315622054040432,
0.009960654191672802,
0.025895506143569946,
0.02126111090183258,
-0.02306215465068817,
0.04148991405963898,
-0.0033412668853998184,
0.006896682549268007,
-0.017779823392629623,
-0.010306586511433125,
-0.026708170771598816,
0.024599632248282433,
-0.039952438324689865,
0.009872798807919025,
-0.021612534299492836,
0.023677146062254906,
-0.03481287136673927,
0.01537476945668459,
0.006199326831847429,
-0.00994967296719551,
-0.03652606159448624,
0.021019507199525833,
-0.004477901849895716,
0.031210782006382942,
0.0014962945133447647,
-0.017417417839169502,
-0.0229084063321352,
0.010345024056732655,
-0.026137107983231544,
0.006699007004499435,
-0.010608591139316559,
0.017131885513663292,
0.008835001848638058,
-0.008829510770738125,
0.024050533771514893,
-0.017230724915862083,
-0.013277212157845497,
0.021348966285586357,
0.01854856126010418,
-0.018603472039103508,
0.006062052212655544,
-0.02304019033908844,
-0.016264310106635094,
-0.012815969064831734,
0.023523397743701935,
-0.0382392480969429,
-0.014957454986870289,
-0.043664347380399704,
-0.027432981878519058,
-0.0036954358220100403,
0.056095946580171585,
0.012058212421834469,
0.0000666640407871455,
-0.04052349925041199,
0.028355468064546585,
0.004892471246421337,
0.004746960010379553,
-0.022051813080906868,
0.01622038148343563,
0.0013267602771520615,
0.04025993496179581,
-0.04190722852945328,
0.027784405276179314,
-0.009378609247505665,
0.08693334460258484,
-0.013771400786936283,
-0.01580306701362133,
0.0030529899522662163,
-0.008423177525401115,
0.002923951717093587,
0.02745494619011879,
0.009197407402098179,
0.0019259644905105233,
0.016242345795035362,
0.008785583078861237,
0.02157958783209324,
0.016176454722881317,
-0.015210039913654327,
0.00541960634291172,
0.00963668618351221,
0.029870981350541115,
0.00486501632258296,
0.03588910400867462,
0.03793175518512726,
0.001663769711740315,
-0.010405424982309341,
-0.014342463575303555,
-0.011904465034604073,
0.012925788760185242,
-0.02251305617392063,
-0.05490989238023758,
0.015660300850868225,
0.02745494619011879,
0.012585347518324852,
-0.010652518831193447,
0.012332761660218239,
0.006479367148131132,
0.02690584771335125,
0.019361227750778198,
0.02402856945991516,
0.05477811023592949,
-0.0023199429269880056,
-0.04722250625491142,
0.009378609247505665,
-0.03479090705513954,
0.023940712213516235,
-0.02440195530653,
-0.02089870534837246,
-0.0018477179110050201,
-0.005614536348730326,
-0.015155130065977573,
0.011135726235806942,
0.009395082481205463,
0.025082839652895927,
-0.006276200525462627,
-0.045465391129255295,
0.07634671777486801,
0.009060132317245007,
-0.020525317639112473,
0.004123732913285494,
-0.022183597087860107,
-0.0011050616158172488,
0.0035087422002106905,
0.007835641503334045,
0.00409353245049715,
-0.013991040177643299,
0.005383914802223444,
-0.009098568931221962,
0.03202344849705696,
-0.043949879705905914,
-0.009466465562582016,
0.0018710546428337693,
0.0195369403809309,
0.029497593641281128,
-0.0216235164552927,
-0.013848274946212769,
0.007132795173674822,
0.030046693980693817,
0.022820550948381424,
-0.0025588010903447866,
-0.0035142330452799797,
0.017417417839169502,
-0.03960101306438446,
-0.029870981350541115,
-0.023259829729795456,
0.0332314670085907,
0.014990400522947311,
-0.02334768697619438,
-0.02095361426472664,
0.009169952012598515,
0.003544433508068323,
-0.059566251933574677,
-0.04994603991508484,
0.041314203292131424,
0.016077617183327675,
0.030529899522662163,
-0.022458145394921303,
0.019888363778591156,
-0.00302004418335855,
0.03766818717122078,
-0.005010527558624744,
-0.017428399994969368,
-0.014002022333443165,
-0.015682265162467957,
-0.029036350548267365,
-0.06606758385896683,
-0.0017200523288920522,
-0.025170695036649704,
-0.003714654128998518,
0.0014455029740929604,
0.015868958085775375,
0.003909584134817123,
0.00913151539862156,
0.01705501228570938,
0.002416035160422325,
0.04599252715706825,
0.011531077325344086,
-0.007324979640543461,
-0.005051710177212954,
0.0150343282148242,
-0.008104699663817883,
-0.024885162711143494,
-0.01158598717302084,
0.016879301518201828,
0.0491553358733654,
0.02936580963432789,
-0.01537476945668459,
-0.04320310428738594,
-0.004228061530739069,
-0.0037448545917868614,
0.06725363433361053,
-0.036921411752700806,
-0.03320950269699097,
-0.017966516315937042,
0.003615816356614232,
0.032221123576164246,
0.011240054853260517,
0.030310260131955147,
0.029892945662140846,
0.015539499931037426,
0.006907664239406586,
0.003308321116492152,
0.02651049569249153,
0.010460334829986095,
0.022666804492473602,
-0.01580306701362133,
-0.01904275082051754,
-0.003261647652834654,
0.01337604969739914,
0.009384100325405598,
0.008049789816141129,
0.0033659765031188726,
-0.0003188205591868609,
0.014946472831070423,
0.033736638724803925,
0.009071114473044872,
-0.008033317513763905,
-0.0029980801045894623,
0.01065800990909338,
-0.00209618522785604,
0.015286914072930813,
0.005449806805700064,
0.029717233031988144,
-0.007440290413796902,
-0.03935940936207771,
-0.013496851548552513,
-0.010416406206786633,
0.02897045947611332,
0.007456763181835413,
0.0007460881606675684,
-0.0003157318860758096,
-0.009812397882342339,
0.006468385457992554,
-0.00631463760510087,
-0.027103522792458534,
0.0078905513510108,
-0.0245776679366827,
-0.012958734296262264,
0.010218731127679348,
-0.015605391003191471,
0.020151929929852486,
-0.010861176997423172,
-0.008220010437071323,
-0.00579299358651042,
-0.01724170707166195,
0.007819168269634247,
-0.04124831035733223,
0.004881489556282759,
0.00579299358651042,
-0.021766280755400658,
-0.005076419562101364,
-0.0466514453291893,
0.011229072697460651,
0.008368267677724361,
-0.059829819947481155,
0.017955534160137177,
0.009444501250982285,
-0.01546262577176094,
0.01648394949734211,
0.030112585052847862,
-0.009570794180035591,
0.017461346462368965,
0.010910595767199993,
-0.010833721607923508,
-0.001984992530196905,
-0.00523840356618166,
0.014715851284563541,
-0.031254712492227554,
-0.029607413336634636,
-0.0002259885222883895,
0.020053092390298843,
-0.0038189829792827368,
-0.021206200122833252,
-0.017142867669463158,
0.02510480210185051,
0.004620667546987534,
0.01601172424852848,
-0.041072599589824677,
-0.01316739246249199,
0.019734615460038185,
-0.010526226833462715,
0.00665507884696126,
-0.007412835489958525,
-0.010927069000899792,
-0.01951497606933117,
0.0021538406144827604,
0.014452283270657063,
0.01510022021830082,
0.016802426427602768,
0.0034922691993415356,
-0.011959374882280827,
-0.014858616515994072,
-0.0037805461324751377,
-0.03103507123887539,
0.04774964228272438,
-0.006841772701591253,
-0.04192919284105301,
0.04458683356642723,
0.007149267941713333,
0.0012032130034640431,
0.011981338262557983,
-0.010817248374223709,
-0.020591210573911667,
0.0022732694633305073,
-0.008401213213801384,
0.0008469850872643292,
0.024226244539022446,
-0.029036350548267365,
-0.0157811027020216,
0.009400573559105396,
-0.040743138641119,
0.0006057247519493103,
0.01731858029961586,
0.006320128683000803,
-0.003593852510675788,
0.031013106927275658,
-0.019493011757731438,
-0.025148730725049973,
0.0012711640447378159,
0.02178824506700039,
0.0361526720225811,
0.028047973290085793,
0.023830892518162727,
0.025588009506464005,
0.015177094377577305,
0.0019767561461776495,
-0.005458043422549963,
-0.0035252152010798454,
-0.00918093416839838,
-0.019207481294870377,
-0.053635984659194946,
-0.018295975401997566,
0.01906471513211727,
0.004332390613853931,
0.011531077325344086,
-0.004650868009775877,
0.003495014738291502,
0.024929091334342957,
-0.004483392927795649,
-0.023655181750655174,
0.010432879440486431,
-0.002799031790345907,
-0.018394814804196358,
-0.024182315915822983,
-0.030464008450508118,
-0.030398117378354073,
0.02802600897848606,
0.004052349831908941,
0.021041471511125565,
0.0013041099300608039,
0.03505447506904602,
0.014704869128763676,
-0.013299175538122654,
0.0046234130859375,
-0.01972363330423832,
-0.021590569987893105,
-0.06650686264038086,
0.008456123061478138,
-0.020228805020451546,
-0.012717131525278091,
0.014957454986870289,
-0.040347788482904434,
-0.031518276780843735,
-0.02220556139945984,
0.020909687504172325,
0.00886794738471508,
0.004933653865009546,
0.0020206840708851814,
-0.007341452408581972,
-0.01072390191257,
0.02730119787156582,
0.011728753335773945,
-0.034263771027326584,
0.01792258955538273,
0.006583696231245995,
-0.006567222997546196,
0.04443308338522911,
-0.008445141837000847,
-0.02596139721572399,
0.001269104890525341,
-0.018526596948504448,
0.017065994441509247,
-0.03729479759931564,
0.019031768664717674,
0.0075171641074121,
-0.003146336879581213,
0.024994982406497,
0.03755836561322212,
0.03020044043660164,
-0.019449083134531975,
-0.015616373158991337,
0.009137006476521492,
0.02855314314365387,
0.010460334829986095,
0.03312164545059204,
0.017439382150769234,
-0.016176454722881317,
-0.006451912224292755,
-0.02042648009955883,
0.009104060009121895,
-0.011981338262557983,
-0.014496211893856525,
0.019602831453084946,
0.03063971921801567,
-0.008368267677724361,
0.012783022597432137,
-0.014166751876473427,
0.0024064260069280863,
0.00036583715700544417,
0.011333402246236801,
0.013518815860152245,
0.007972916588187218,
0.011904465034604073,
0.0026178290136158466,
0.02048138901591301,
0.014254608191549778,
-0.005438824649900198,
0.011662861332297325,
0.024511776864528656,
-0.047266434878110886,
0.025192659348249435,
0.006067543290555477,
0.032880041748285294,
-0.030442044138908386,
-0.04089688882231712,
0.010652518831193447,
0.005749065894633532,
0.0060510700568556786,
0.020338624715805054,
0.031408458948135376,
0.005279586184769869,
-0.03509840369224548,
0.024050533771514893,
0.03584517911076546,
-0.015792084857821465,
-0.011256528086960316,
0.000032388255931437016,
0.004486138001084328,
-0.023106083273887634,
-0.011509113013744354,
0.005477261729538441,
0.024599632248282433,
-0.015638336539268494,
-0.02719137817621231,
-0.00961472187191248,
-0.017428399994969368,
-0.008522015064954758,
-0.012321779504418373,
0.011596969328820705,
0.027235306799411774,
-0.031386494636535645,
-0.05192279443144798,
0.006199326831847429,
0.0011373211164027452,
-0.04867212846875191,
-0.0052713495679199696,
-0.026290856301784515,
-0.0011956628877669573,
0.055700596421957016,
-0.021217182278633118,
-0.004293953534215689,
0.05728200078010559,
0.0023268067743629217,
-0.012387671507894993,
0.015693247318267822,
0.02116227336227894,
-0.010751357302069664,
-0.017933571711182594,
-0.03549375385046005,
-0.010888631455600262,
0.019163552671670914,
0.017724912613630295,
0.017252687364816666,
0.03202344849705696,
0.023435542359948158,
-0.021755298599600792,
-0.014737814664840698,
-0.008362776599824429,
0.0026233200915157795,
0.01956988498568535,
-0.00027695175958797336,
0.0036734717432409525,
0.0030996634159237146,
-0.027828333899378777,
-0.019141588360071182,
-0.02826761268079281,
0.018845075741410255,
-0.003212228650227189,
0.005919286515563726,
0.024314099922776222,
0.028597071766853333,
-0.011333402246236801,
-0.0014523667050525546,
0.03270433098077774,
0.042566150426864624,
-0.00773131288588047,
0.022293416783213615,
0.021140309050679207,
-0.016055652871727943,
-0.025302479043602943,
0.015089238062500954,
0.014408355578780174,
-0.0412263460457325,
-0.022710731253027916,
0.02097557857632637,
0.0043268995359539986,
-0.0017118159448727965,
0.023786965757608414,
-0.0028662963304668665,
-0.0016788699431344867,
-0.009867307730019093,
-0.02137093059718609,
-0.033473070710897446,
0.007270069792866707,
-0.016418058425188065,
-0.01635216549038887,
-0.013112482614815235,
0.023435542359948158,
-0.009367628023028374,
0.014924508519470692,
0.014100860804319382,
0.00149354909081012,
0.019976219162344933,
0.00045540891005657613,
-0.01826303079724312,
-0.009697087109088898,
-0.0124974912032485,
-0.007187705021351576,
-0.010152839124202728,
-0.045597173273563385,
-0.049726396799087524,
0.016857337206602097,
-0.018460705876350403,
0.004727741703391075,
-0.054822035133838654,
-0.003566397586837411,
0.010954523459076881,
-0.016516895964741707,
0.011761698871850967,
0.0382392480969429,
-0.001172326155938208,
0.0027935407124459743,
-0.031693991273641586,
0.016868319362401962,
-0.008159610442817211,
0.02512676641345024,
0.0020865758415311575,
0.011476167477667332,
-0.005455297883599997,
-0.0002845018752850592,
-0.008351794444024563,
-0.01167384348809719,
-0.002454472240060568,
0.010388951748609543,
-0.040237970650196075,
-0.003278120653703809,
0.02444588392972946,
-0.0245776679366827,
-0.011992320418357849,
0.017362507060170174,
-0.018790164962410927,
-0.01010891143232584,
0.018482670187950134,
0.027389055117964745,
0.039271555840969086,
0.019317300990223885,
-0.01836186833679676,
-0.026005325838923454,
-0.002626065630465746,
0.04100670665502548,
-0.018372850492596626,
0.014518175274133682,
0.055524881929159164,
-0.015308878384530544,
0.002687839325517416,
-0.001329505816102028,
-0.0026343020144850016,
-0.04138009622693062,
0.011168671771883965,
-0.03173791617155075,
-0.016077617183327675,
-0.005869867280125618,
-0.03639427572488785,
0.018394814804196358,
0.003692690283060074,
0.0006596050807274878,
-0.0014743306674063206,
0.01980050653219223,
-0.014056932181119919,
0.006001651287078857,
-0.013189355842769146,
-0.01435344573110342,
0.01888900250196457,
-0.02275465987622738,
-0.026137107983231544,
0.024248208850622177,
0.008780092000961304,
-0.01627529226243496,
0.027498874813318253,
0.014452283270657063,
-0.02385285682976246,
0.007489709183573723,
-0.005120347253978252,
-0.004373572766780853,
0.02014094777405262,
0.01633020117878914,
-0.02567586489021778,
0.023281794041395187,
0.010965505614876747,
0.011750716716051102,
0.035515718162059784,
0.026993703097105026,
-0.011772681027650833,
-0.006237763911485672,
-0.03549375385046005,
-0.003256156574934721,
-0.005694156046956778,
-0.005880849435925484,
0.09655355662107468,
-0.008406704291701317,
0.017076976597309113,
-0.0036075799725949764,
-0.010795284993946552,
-0.0032698840368539095,
0.0010583881521597505,
-0.0292340274900198,
0.02071201056241989,
-0.038305141031742096,
0.02427017316222191,
-0.003956257831305265,
0.020459426566958427,
0.003720145206898451,
0.004318662919104099,
-0.023699110373854637,
-0.03764622285962105,
0.036613915115594864,
-0.020206840708851814,
-0.010372478514909744,
-0.023699110373854637,
0.012387671507894993,
-0.02716941386461258,
0.029036350548267365,
-0.004107260145246983,
-0.04056742787361145,
-0.010861176997423172,
-0.012365708127617836,
0.01256338320672512,
-0.02042648009955883,
0.001669260673224926,
0.023479469120502472,
0.02334768697619438,
-0.025478189811110497,
0.004112750757485628,
-0.014869598671793938,
-0.019888363778591156,
-0.02306215465068817,
0.006973556242883205,
0.02468748763203621,
0.013321139849722385,
0.023523397743701935,
0.04357649013400078,
0.036372311413288116,
0.023369649425148964,
0.022447163239121437,
-0.02165646106004715,
-0.02954152226448059,
-0.007769749965518713,
-0.013639617711305618,
-0.003956257831305265,
0.010828230530023575,
0.02387482114136219,
0.013288194313645363,
0.0000986662125797011,
-0.00496385432779789,
0.024358028545975685,
0.0022265962325036526,
-0.021217182278633118,
-0.04190722852945328,
-0.010460334829986095,
0.013332122005522251,
0.009922217577695847,
-0.007703857962042093,
0.03876638412475586
] | 2024-07-10 | 66 | 38982561 | [
"reduced suppressive myeloid cell presence",
"tumor-specific T cells",
"potent anti-tumor responses",
"greater T-cell infiltration",
"Chimeric antigen receptor",
"interleukin-13 receptor subunit",
"limited clinical efficacy",
"GBM",
"syngeneic models",
"bispecific IL-13Rα2/TGF-β CAR-T cells",
"tumor-specific T-cell responses",
"Bispecific IL-13Rα2/TGF-β CAR-T cells",
"TME",
"IL-13Rα2/TGF-β CAR-T cells",
"more potent GBM-targeting CAR-T cells",
"conventional IL-13Rα2 CAR-T cells",
"(CAR)-T cell therapies",
"bispecific CAR",
"inhibitory molecules",
"murine glioma",
"growth factor",
"efficacy",
"TGF-β",
"improved survival",
"an immunosuppressive tumor microenvironment",
"TGF-β-mediated immune suppression",
"both patient-derived GBM xenografts",
"CAR",
"interleukin-13",
"alpha-2"
] | [
"CAR-T cell therapy",
"TGF-β",
"glioblastoma",
"immunotherapy",
"tumor microenvironment"
] | 0 | 10.1093/neuonc/noae126
10.3389/fmed.2020.00182 | [
"Hou",
"Shih",
"Uy",
"Shafer",
"Chang",
"Comin-Anduix",
"Guemes",
"Galic",
"Phyu",
"Okada",
"Grausam",
"Breunig",
"Brown",
"Nathanson",
"Prins",
"Chen"
] | [
"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA.",
"Department of Molecular Biology, University of California, Los Angeles, California, USA.",
"Department of Neurosurgery, University of California, Los Angeles, California, USA.",
"Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.",
"Department of Molecular Biology, University of California, Los Angeles, California, USA.",
"Department of Surgery, University of California, Los Angeles, California, USA.\nJonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.",
"Department of Medicine, Division of Hematology/Oncology, University of California, Los Angeles, California, USA.",
"Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.\nDepartment of Medicine, Division of Hematology/Oncology, University of California, Los Angeles, California, USA.",
"Department of Neurosurgery, University of California, San Francisco, California, USA.",
"Department of Neurosurgery, University of California, San Francisco, California, USA.\nParker Institute for Cancer Immunotherapy Center at UCSF, San Francisco, California, USA.",
"Board of Governor's Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.",
"Board of Governor's Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.",
"Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, USA.",
"Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.\nDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.",
"Department of Neurosurgery, University of California, Los Angeles, California, USA.\nJonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.\nDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA.",
"Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA.\nDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.\nJonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.\nParker Institute for Cancer Immunotherapy Center at UCLA, Los Angeles, California, USA."
] | [
"38982561",
"32328653",
"34516954",
"35314842",
"34175021",
"32888407",
"24204956",
"30572904",
"28029927",
"22424217",
"17327604",
"38454126",
"21628493",
"24925914",
"18772890",
"24120142",
"28426845",
"29016929",
"33972771",
"19896441",
"19345330",
"17292826",
"20667896",
"22437938",
"25424852",
"26902851",
"32140889",
"29377003",
"30065964",
"32132216",
"32385241",
"36409926",
"30882787",
"34062119",
"9592393",
"10541355",
"29103912",
"11964281",
"29315015",
"29807781",
"35314843",
"21677751",
"15921683",
"29262845",
"28235764",
"34836966",
"15320871",
"34469737",
"32528967",
"31609000",
"25065622",
"16900348",
"28758994",
"24316888",
"29775591",
"36142162",
"30471926",
"35444279",
"21859884",
"25579378",
"29880586",
"36387056",
"9180086",
"22047558",
"35130560",
"32002651"
] | [] | 9.959305 | 7.264526 |
38981470 | 745 | Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies. | Allogeneic cellular immunotherapies hold promise for broad clinical implementation but face limitations due to potential rejection of donor cells by the host immune system. Silencing of beta-2 microglobulin (B2M) expression is commonly employed to evade T cell-mediated rejection by the host, although the absence of B2M is expected to trigger missing-self responses by host natural killer (NK) cells. Here, we demonstrate that genetic deletion of the adhesion ligands CD54 and CD58 in B2M-deficient chimeric antigen receptor (CAR) T cells and multi-edited induced pluripotent stem cell (iPSC)-derived CAR NK cells reduces their susceptibility to rejection by host NK cells in vitro and in vivo. The absence of adhesion ligands limits rejection in a unidirectional manner in B2M-deficient and B2M-sufficient settings without affecting the antitumor functionality of the engineered donor cells. Thus, these data suggest that genetic ablation of adhesion ligands effectively alleviates rejection by host immune cells, facilitating the implementation of universal immunotherapy. | [
0.004845493473112583,
0.021609270945191383,
0.05552491545677185,
0.04711068421602249,
-0.050980329513549805,
-0.029382308945059776,
-0.045220859348773956,
0.000026189007257926278,
-0.03646915778517723,
0.009179159067571163,
-0.0015650128480046988,
-0.011305214837193489,
-0.03138462454080582,
0.02083309181034565,
0.053410109132528305,
-0.0052588931284844875,
0.05835965275764465,
-0.018290825188159943,
0.01411745697259903,
0.012272626161575317,
0.043173544108867645,
0.031092151999473572,
0.008678579702973366,
0.023127881810069084,
-0.018358318135142326,
-0.027807453647255898,
0.040563784539699554,
-0.002304632682353258,
0.007874278351664543,
-0.031542111188173294,
0.031947072595357895,
-0.010394047945737839,
-0.006265676114708185,
0.0068000019527971745,
-0.032352037727832794,
0.034354351460933685,
0.03601920232176781,
0.00342812342569232,
-0.05071035400032997,
-0.026885036379098892,
0.030732184648513794,
-0.0015622006030753255,
0.021249303594231606,
0.0782928317785263,
-0.07680796086788177,
0.023105382919311523,
0.02032688818871975,
-0.04886552318930626,
0.04760563746094704,
-0.012643842026591301,
-0.01098461914807558,
0.007986768148839474,
-0.043173544108867645,
0.031204640865325928,
-0.06281424313783646,
0.05471498891711235,
-0.003765592584386468,
-0.013588755391538143,
-0.027964938431978226,
0.01865079067647457,
-0.02182300016283989,
0.0014468986773863435,
0.028009934350848198,
0.00003680082954815589,
-0.011344585567712784,
-0.012475106865167618,
-0.029494797810912132,
-0.03563673421740532,
0.011496447026729584,
0.02546766772866249,
-0.008059886284172535,
-0.04189116135239601,
-0.02585013210773468,
-0.007930523715913296,
0.01791960932314396,
0.009229779243469238,
0.002836146391928196,
0.03367941454052925,
-0.016569731757044792,
-0.007469316013157368,
0.0473356656730175,
0.018819525837898254,
0.012283874675631523,
-0.052420198917388916,
-0.0017196862027049065,
0.010500913485884666,
0.01611977256834507,
0.02321787364780903,
-0.06965362280607224,
-0.005227958783507347,
-0.009167910553514957,
-0.010095950216054916,
-0.04202615097165108,
0.08319737762212753,
0.0028066178783774376,
0.02886485680937767,
-0.0025310181081295013,
-0.07478314638137817,
0.01844830997288227,
0.02585013210773468,
0.012598846107721329,
-0.0001010649575619027,
-0.009803476743400097,
-0.01911200024187565,
0.028707370162010193,
-0.0035490498412400484,
-0.036536652594804764,
0.013948721811175346,
-0.017750874161720276,
0.03727908432483673,
0.10016082227230072,
-0.0030259727500379086,
0.015804802998900414,
0.04643574729561806,
-0.024365268647670746,
-0.046390749514102936,
-0.04841556400060654,
0.019471965730190277,
0.016895951703190804,
0.04123872146010399,
-0.00018086233467329293,
0.029607288539409637,
0.03424186259508133,
-0.031992070376873016,
-0.02196923829615116,
-0.0025000835303217173,
0.081307552754879,
-0.004634575452655554,
-0.06110440194606781,
-0.05633483827114105,
0.042566101998090744,
0.007351201493293047,
0.030147237703204155,
-0.0063219210132956505,
-0.06668388843536377,
0.016007283702492714,
0.013622501865029335,
-0.029517296701669693,
-0.02250918745994568,
0.0026238220743834972,
-0.002179487841203809,
-0.020281892269849777,
0.005787594709545374,
0.004280232824385166,
-0.06744882464408875,
-0.01725591905415058,
0.029404805973172188,
0.016254760324954987,
0.007913650013506413,
0.053590092808008194,
-0.002550703939050436,
0.06245427951216698,
0.04931548237800598,
0.023712828755378723,
-0.04562582075595856,
-0.038561467081308365,
-0.030912168323993683,
0.050350386649370193,
0.0224529430270195,
-0.043376028537750244,
-0.0007726636249572039,
0.0019615390338003635,
-0.013172543607652187,
-0.01137833297252655,
-0.008611085824668407,
0.008369233459234238,
-0.00480331014841795,
0.042791079729795456,
-0.052555184811353683,
-0.007182467263191938,
0.007581805344671011,
-0.005776345729827881,
-0.07163343578577042,
-0.020968079566955566,
-0.05156527832150459,
0.02222796343266964,
0.024567749351263046,
-0.02324037067592144,
-0.01672721840441227,
-0.0030569075606763363,
0.02486022189259529,
0.006288174074143171,
0.06965362280607224,
-0.006749381776899099,
-0.03221704810857773,
0.011845164932310581,
-0.008487347513437271,
0.02926981821656227,
-0.037144098430871964,
-0.027402490377426147,
0.029359810054302216,
-0.018054597079753876,
0.038179002702236176,
0.021935490891337395,
0.011957654729485512,
-0.04101374372839928,
0.014398680999875069,
0.009359142743051052,
-0.005725725553929806,
-0.028414897620677948,
0.01964070089161396,
-0.024747733026742935,
-0.021001826971769333,
-0.02787494659423828,
-0.009511004202067852,
-0.01901075802743435,
-0.023195374757051468,
0.022340454161167145,
-0.012835074216127396,
0.030777180567383766,
0.044748399406671524,
-0.005149215925484896,
-0.01500612497329712,
0.018515804782509804,
-0.017244670540094376,
-0.01371249370276928,
0.0033550052903592587,
0.030574699863791466,
-0.01992192491889,
0.026210099458694458,
-0.012081393040716648,
-0.050170402973890305,
-0.011063361540436745,
0.003546237712725997,
-0.03806651383638382,
0.010748390108346939,
0.002066998044028878,
-0.009252277202904224,
-0.017278417944908142,
-0.013352527283132076,
-0.01382498349994421,
0.02285790629684925,
0.019303232431411743,
-0.041193727403879166,
-0.011389581486582756,
0.00852671917527914,
0.013600003905594349,
0.005706039723008871,
0.05291515216231346,
-0.03973136097192764,
0.03140712156891823,
0.013847481459379196,
0.021530527621507645,
0.0027053772937506437,
-0.015399839729070663,
-0.0031665849965065718,
-0.010152194648981094,
-0.06767380237579346,
0.00865608174353838,
-0.025895128026604652,
-0.021024323999881744,
0.04180116951465607,
-0.0017731188563629985,
0.007705544121563435,
-0.001329487538896501,
0.05606486275792122,
0.037774041295051575,
0.012328870594501495,
0.010517786256968975,
0.0013287845067679882,
-0.043376028537750244,
-0.01562481839209795,
-0.02146303467452526,
-0.00800926610827446,
-0.030957164242863655,
0.019201990216970444,
0.0007382136536762118,
0.020698104053735733,
0.03867395594716072,
0.008982302621006966,
0.03442184627056122,
-0.005332011729478836,
0.002246981719508767,
-0.019685696810483932,
-0.04150869697332382,
-0.014567415229976177,
-0.042363617569208145,
0.055569909512996674,
-0.0020571553613990545,
0.004223987925797701,
-0.0189095176756382,
0.03271200507879257,
0.005455750040709972,
-0.025130197405815125,
-0.004699257202446461,
-0.014027465134859085,
0.022520437836647034,
0.028324905782938004,
-0.03183458372950554,
-0.03649165853857994,
-0.0038752700202167034,
-0.005855088587850332,
-0.006417537108063698,
-0.010090325959026814,
-0.018594546243548393,
-0.014713652431964874,
-0.0024030611384660006,
-0.025737643241882324,
-0.01586104743182659,
0.028122423216700554,
-0.029764773324131966,
0.005551366601139307,
0.002812242368236184,
-0.014522419311106205,
-0.01231762208044529,
0.024972712621092796,
-0.0034365602768957615,
0.015219856053590775,
0.034534335136413574,
0.023600338026881218,
-0.03682912513613701,
-0.02065310813486576,
-0.03248702362179756,
0.05826966091990471,
-0.010500913485884666,
0.002486022189259529,
-0.0025999180506914854,
-0.06474906951189041,
0.016389748081564903,
-0.04229612648487091,
-0.037166595458984375,
0.00686187157407403,
-0.046165771782398224,
-0.006423161830753088,
0.03361191973090172,
0.0025450794491916895,
0.029337313026189804,
-0.019753189757466316,
0.010236562229692936,
-0.014691154472529888,
-0.0043364777229726315,
-0.01581605151295662,
0.031947072595357895,
-0.021429287269711494,
-0.013127547688782215,
-0.025535160675644875,
-0.053410109132528305,
0.00003713038677233271,
0.003124401206150651,
0.007570556364953518,
0.014207448810338974,
0.056424830108881,
-0.030619695782661438,
0.03583921864628792,
0.03511928394436836,
-0.04425344616174698,
-0.013779987581074238,
0.008239869959652424,
0.013442518189549446,
0.0036165437195450068,
0.011097108945250511,
0.03307196870446205,
0.004600828513503075,
0.006693136878311634,
-0.023352861404418945,
0.047965604811906815,
0.030169736593961716,
-0.002678660908713937,
0.018977012485265732,
0.005337635986506939,
0.01695219799876213,
-0.027559975162148476,
-0.032554518431425095,
0.009842848405241966,
0.05350010097026825,
0.029742276296019554,
-0.045940790325403214,
0.03991134464740753,
-0.06438910216093063,
-0.02501770853996277,
-0.025535160675644875,
0.016783462837338448,
-0.004676759243011475,
0.012295124121010303,
-0.027784954756498337,
0.04346601665019989,
0.019269485026597977,
0.021654266864061356,
0.019224489107728004,
-0.022036731243133545,
0.03806651383638382,
-0.0038752700202167034,
0.019831933081150055,
-0.03865145891904831,
-0.007548058405518532,
0.00888106133788824,
0.021451784297823906,
-0.020180651918053627,
-0.06317421048879623,
0.03331944718956947,
0.0011129449121654034,
-0.004671134520322084,
0.008352359756827354,
0.00841422937810421,
-0.012565098702907562,
0.033746909350156784,
-0.06420911848545074,
0.05111531913280487,
0.0768529623746872,
0.02306038700044155,
-0.02564765140414238,
-0.025940123945474625,
-0.0033915643580257893,
-0.03671663627028465,
0.004761126358062029,
-0.04546833410859108,
0.03880894556641579,
-0.00241993460804224,
0.014083709567785263,
0.00004123889812035486,
-0.011991401202976704,
0.0032593889627605677,
0.0376165546476841,
0.009533502161502838,
0.020574364811182022,
-0.032936982810497284,
-0.02115931175649166,
0.06515403091907501,
0.02504020556807518,
-0.0032678255811333656,
-0.000495657732244581,
-0.011946405284106731,
0.02564765140414238,
-0.03185708075761795,
0.005694790743291378,
-0.026165103539824486,
0.03988884761929512,
0.016400998458266258,
0.006788752973079681,
-0.08580713719129562,
-0.0455133318901062,
0.045198358595371246,
0.02222796343266964,
-0.07167843729257584,
-0.03703160956501961,
0.033544428646564484,
-0.014308689162135124,
0.015681063756346703,
-0.05386006459593773,
0.038381483405828476,
-0.029179826378822327,
-0.010889002121984959,
-0.042206134647130966,
-0.018234578892588615,
0.031002160161733627,
0.014173701405525208,
-0.02212672308087349,
0.0007972707389853895,
-0.018797028809785843,
-0.017975853756070137,
-0.023487849161028862,
-0.04567081481218338,
-0.009387264959514141,
0.014016215689480305,
-0.017064686864614487,
-0.03408437967300415,
0.05431002378463745,
-0.04148619994521141,
-0.012351368553936481,
-0.005146403796970844,
0.05089033767580986,
-0.04506337270140648,
0.012497604824602604,
-0.02904483862221241,
-0.016772214323282242,
0.06659390032291412,
0.014376183040440083,
-0.004063690081238747,
-0.006406288128346205,
-0.051790256053209305,
0.02230670675635338,
-0.013240037485957146,
-0.020945580676198006,
0.017773371189832687,
-0.03311696648597717,
0.03264451026916504,
0.004302730783820152,
0.009257902391254902,
0.009752856567502022,
0.014364934526383877,
0.009837224148213863,
-0.009741608053445816,
-0.030709687620401382,
-0.059844519942998886,
0.056829795241355896,
0.01353251002728939,
-0.0029556667432188988,
0.011968903243541718,
-0.011243345215916634,
0.025355177000164986,
0.012047646567225456,
-0.006816875655204058,
0.026300091296434402,
-0.00852671917527914,
0.015973536297678947,
-0.006710010580718517,
0.04101374372839928,
-0.007711168844252825,
0.0093028973788023,
0.015219856053590775,
-0.01700844243168831,
0.021001826971769333,
-0.007148720324039459,
0.0074918135069310665,
0.030979663133621216,
0.0493604801595211,
-0.004356163553893566,
0.004879240412265062,
-0.0072049652226269245,
-0.0038640210404992104,
-0.06033947318792343,
-0.03192457556724548,
0.019280733540654182,
-0.01781836710870266,
-0.04769562929868698,
-0.006844997871667147,
-0.03732408210635185,
-0.001663441420532763,
-0.022014234215021133,
-0.011338961310684681,
-0.024747733026742935,
-0.02222796343266964,
-0.017784621566534042,
0.009477256797254086,
0.006181308999657631,
0.003197519574314356,
-0.05570489913225174,
-0.02706502005457878,
-0.015827300027012825,
-0.04168868064880371,
0.040136322379112244,
0.00845360103994608,
0.01723342202603817,
0.03664914146065712,
-0.0017028127331286669,
-0.023262869566679,
0.013375025242567062,
0.023735325783491135,
0.024072794243693352,
-0.04072127118706703,
0.022599179297685623,
-0.03349943086504936,
0.017829617485404015,
-0.011383957229554653,
-0.011277091689407825,
0.0039624497294425964,
0.023397857323288918,
-0.01642349548637867,
0.020214397460222244,
0.019696945324540138,
0.01181141845881939,
0.00595070468261838,
0.03289198875427246,
-0.01523110456764698,
0.014319938607513905,
-0.03223954513669014,
-0.006878744810819626,
-0.013678747229278088,
0.0013421426992863417,
0.02967478148639202,
-0.03511928394436836,
-0.005939456168562174,
0.019348228350281715,
-0.008993551135063171,
-0.01181141845881939,
-0.021193059161305428,
-0.0202256478369236,
0.01776212267577648,
-0.020338136702775955,
0.033971887081861496,
-0.049000512808561325,
0.007024981547147036,
-0.00985972210764885,
0.00017805008974391967,
0.05516494810581207,
0.019696945324540138,
0.008616711013019085,
0.0002511683851480484,
0.006732508074492216,
0.0013196447398513556,
-0.023555342108011246,
-0.010529035702347755,
-0.018054597079753876,
0.032127056270837784,
-0.009016049094498158,
0.028977345675230026,
-0.033994387835264206,
-0.03570422902703285,
-0.021474283188581467,
-0.017795870080590248,
0.015591071918606758,
-0.028324905782938004,
0.04949546605348587,
0.019393224269151688,
-0.03082217648625374,
0.030169736593961716,
-0.003695286577567458,
0.02726750262081623,
-0.0074243200942873955,
-0.018189582973718643,
0.038606464862823486,
-0.022362951189279556,
-0.024522753432393074,
-0.028009934350848198,
0.005090158898383379,
0.03349943086504936,
0.006310672033578157,
-0.019573207944631577,
-0.013588755391538143,
0.023577840998768806,
0.03928140178322792,
0.039776355028152466,
-0.010444668121635914,
-0.0004791358078364283,
-0.003211580915376544,
-0.005174526013433933,
-0.025152696296572685,
-0.01903325691819191,
0.011552691459655762,
-0.028527386486530304,
-0.0008809349383227527,
0.01361125335097313,
-0.02987726405262947,
0.029494797810912132,
-0.013071302324533463,
-0.04294856637716293,
0.0019545084796845913,
-0.004831432364881039,
0.0015903230523690581,
0.001498925150372088,
0.007542434148490429,
-0.009010424837470055,
-0.024387765675783157,
0.04204864799976349,
0.0038246496114879847,
-0.04562582075595856,
0.02607511170208454,
-0.01271133590489626,
-0.01901075802743435,
-0.026300091296434402,
-0.03379190340638161,
-0.01862829364836216,
0.01331877987831831,
-0.03043971210718155,
0.019955672323703766,
-0.008003641851246357,
-0.04643574729561806,
0.0038949556183069944,
0.008582963608205318,
-0.007311830297112465,
-0.02271167002618313,
-0.022880403324961662,
0.029539793729782104,
-0.012160136364400387,
-0.0008331268327310681,
-0.00902167335152626,
0.0052195219323039055,
-0.006040696520358324,
0.0677637904882431,
0.03968636319041252,
-0.01579355262219906,
0.04292606934905052,
-0.026525070890784264,
-0.015782304108142853,
-0.012891319580376148,
-0.007486189249902964,
0.006440035067498684,
0.003695286577567458,
-0.002435402013361454,
-0.019989419728517532,
0.1053803488612175,
-0.000712551933247596,
0.022396698594093323,
-0.022419195622205734,
-0.026997527107596397,
0.0076942951418459415,
-0.02387031354010105,
-0.020338136702775955,
-0.02387031354010105,
-0.011119605973362923,
0.004598016384989023,
0.004561457317322493,
-0.025602655485272408,
-0.06384915113449097,
-0.007986768148839474,
-0.006710010580718517,
0.03088967129588127,
0.013420021161437035,
-0.001721092383377254,
-0.02886485680937767,
0.003380315378308296,
-0.02542267180979252,
-0.008717951364815235,
-0.027942439541220665,
0.008076759986579418,
0.03853897005319595,
0.005630109459161758,
-0.007092475425451994,
-0.007210589479655027,
-0.021350543946027756,
0.015771055594086647,
0.019989419728517532,
0.03284699097275734,
0.005866337567567825,
0.03712160140275955,
-0.00890918355435133,
-0.014646158553659916,
-0.0038358985912054777,
0.012328870594501495,
0.013622501865029335,
-0.008318613283336163,
0.014522419311106205,
-0.014072461053729057,
-0.02425277791917324,
-0.0012830855557695031,
-0.014454926364123821,
0.01212638895958662,
0.0438934788107872,
-0.003475931705906987,
0.017728375270962715,
-0.010292807593941689,
-0.015647316351532936,
-0.006850622594356537,
0.00631629629060626,
0.026975028216838837,
0.04202615097165108,
-0.0382240004837513,
0.07005858421325684,
-0.007047479506582022,
-0.019280733540654182,
-0.0014975190861150622,
0.00040179913048632443,
-0.039191409945487976,
0.004482714459300041,
-0.0009927215287461877,
0.02344285324215889,
-0.015096116811037064,
-0.028932349756360054,
-0.009145412594079971,
-0.0027447484899312258,
0.019449468702077866,
-0.029922259971499443,
-0.011243345215916634,
0.01573730818927288,
-0.021901743486523628,
0.045400843024253845,
0.00285161379724741,
-0.005568239837884903,
0.01812209002673626,
-0.011147729121148586,
-0.008729200810194016,
0.007024981547147036,
-0.033184461295604706,
0.005877586547285318,
-0.0023454101756215096,
-0.01491613406687975,
0.01690720207989216,
0.01303755585104227,
-0.031744591891765594,
-0.03523177281022072,
-0.03527676686644554,
0.013273783959448338,
-0.0021119939628988504,
0.03244202956557274,
-0.01035467628389597,
-0.012058895081281662,
-0.01086087990552187,
0.0017000004881992936,
0.010410921648144722,
0.02306038700044155,
0.009117289446294308,
-0.021856747567653656,
0.006496279966086149,
0.01403871364891529,
0.009308522567152977,
0.01660347916185856,
-0.023600338026881218,
-0.011074610985815525,
-0.02212672308087349,
0.036559149622917175,
-0.016873454675078392,
-0.0074918135069310665,
-0.012756331823766232,
0.007604303304105997,
-0.026570066809654236,
0.005157652776688337,
-0.015028622932732105,
0.012171384878456593,
-0.021609270945191383,
-0.013768739067018032,
-0.030552200973033905,
0.020394381135702133,
-0.05003541707992554,
0.03331944718956947,
-0.025985119864344597,
0.022104226052761078,
0.00523358304053545,
-0.08580713719129562,
0.0019657574594020844,
-0.002386187668889761,
0.032352037727832794,
-0.03187958151102066,
0.012115140445530415,
-0.01692969910800457,
-0.0036137315910309553,
-0.01715467870235443,
-0.008762947283685207,
-0.011980152688920498,
0.027132514864206314,
0.013813734985888004,
0.01411745697259903,
0.02344285324215889,
-0.04063127934932709,
-0.0033746908884495497,
0.0029303566552698612,
0.008689829148352146,
0.0029359811451286077,
0.027312498539686203,
0.01703093945980072,
-0.03561423718929291,
0.02843739464879036,
-0.024972712621092796,
-0.004907363094389439,
0.009960962459445,
-0.009550374932587147,
-0.050395384430885315,
-0.017019690945744514,
-0.004969232250005007,
0.03664914146065712,
-0.04927048832178116,
0.03248702362179756,
-0.0042324247770011425,
-0.022216714918613434,
0.03547925129532814,
-0.0011347398394718766,
0.0009266338893212378,
0.01964070089161396,
0.007069977466017008,
0.017795870080590248,
0.0021344919223338366,
-0.016535984352231026,
-0.031947072595357895,
0.0021218368783593178,
0.009257902391254902,
-0.010191566310822964,
0.006979985628277063,
-0.017177175730466843,
0.007514311466366053,
-0.04040629789233208,
-0.033161960542201996,
0.0007195825455710292,
-0.00440397160127759,
-0.02843739464879036,
0.016389748081564903,
0.04715568199753761,
-0.005646982695907354,
0.033971887081861496,
0.0012437142431735992,
0.04364600032567978,
0.038943931460380554,
0.0006570101249963045,
0.004575518425554037,
0.016412246972322464,
-0.0042324247770011425,
0.022891653701663017,
-0.02366783283650875,
0.030507205054163933,
-0.0392364077270031,
0.00892043299973011,
-0.03158710524439812,
0.035141780972480774,
0.031744591891765594,
-0.0015087680658325553,
-0.024365268647670746,
0.023577840998768806,
-0.02121555618941784,
0.05053037032485008,
-0.012373866513371468,
-0.010512161999940872,
-0.00816112756729126,
0.005275766830891371,
-0.0374140739440918,
0.013588755391538143,
0.014702402986586094,
0.035546742379665375,
-0.005587925668805838,
0.0076661729253828526,
0.014308689162135124,
-0.0010102980304509401,
-0.018639542162418365,
-0.014848640188574791,
-0.01331877987831831,
-0.012463858351111412,
-0.02827990986406803,
0.0024157161824405193,
-0.017863363027572632,
-0.02526518516242504,
0.05395005643367767,
-0.03986634686589241,
0.011164601892232895,
0.007098099682480097,
-0.023532845079898834,
-0.025535160675644875,
0.028774864971637726,
-0.04229612648487091,
-0.02546766772866249,
-0.01201389916241169,
0.03604169934988022,
-0.008931681513786316,
-0.026165103539824486,
0.008605461567640305,
0.005315138027071953,
0.005025477148592472,
0.02075434848666191,
-0.047965604811906815,
0.005691978614777327,
0.013442518189549446,
0.05408504605293274,
0.017773371189832687,
-0.010799011215567589,
-0.025580156594514847,
-0.01741340570151806,
-0.00903292279690504,
0.031002160161733627,
0.006344418972730637,
0.01292506605386734,
0.019100749865174294,
0.009713484905660152,
-0.0011319275945425034,
0.012486356310546398,
-0.030327221378684044,
-0.004673946648836136,
0.046570733189582825,
0.0004675353120546788,
0.03750406578183174,
0.008689829148352146,
0.019022008404135704,
-0.000462965399492532,
-0.01451117079705,
-0.0438934788107872,
-0.005838215351104736,
0.04191366210579872,
-0.000810628873296082,
-0.031789589673280716,
0.03322945535182953,
-0.03151961416006088,
-0.0030259727500379086,
0.007609928026795387,
0.053410109132528305,
0.007148720324039459,
0.05107032135128975,
0.015928540378808975,
-0.01025343593209982,
0.0430835522711277,
-0.03730158135294914,
-0.014061211608350277,
0.03205956146121025,
-0.024342769756913185,
0.03646915778517723,
-0.013993717730045319,
-0.01483739074319601,
-0.012778829783201218,
-0.014364934526383877,
-0.002770058810710907,
0.023307865485548973,
0.05282516032457352,
0.01802084967494011,
-0.024590248242020607,
-0.09503129869699478,
0.05912458524107933,
0.00401025777682662,
-0.036559149622917175,
0.012722584418952465,
0.010866504162549973,
0.004268983844667673,
0.018662041053175926,
0.011541442945599556,
0.007081226445734501,
-0.010635900311172009,
0.030732184648513794,
0.01842581294476986,
0.025692647323012352,
-0.024702737107872963,
0.011198349297046661,
-0.010709019377827644,
0.010304056107997894,
0.002774277236312628,
-0.00241993460804224,
-0.03561423718929291,
0.02230670675635338,
0.042161136865615845,
0.04684070870280266,
-0.01140645518898964,
-0.05201523378491402,
0.0361991822719574,
-0.02265542559325695,
-0.044208452105522156,
-0.042791079729795456,
-0.010821509175002575,
0.03122713975608349,
-0.01524235401302576,
-0.012688837945461273,
0.012790078297257423,
0.007823658175766468,
-0.018358318135142326,
-0.018875770270824432,
0.054579999297857285,
0.0029134831856936216,
0.07068852335214615,
-0.02787494659423828,
0.0186057947576046,
0.024792728945612907,
0.010877753607928753,
0.00852671917527914,
0.00660876976326108,
-0.006614394020289183,
0.007531185168772936,
-0.02585013210773468,
0.012047646567225456,
0.0290223415941,
0.03826899453997612,
-0.003324070479720831,
-0.021283050999045372,
-0.0027377179358154535,
0.00335781741887331,
0.00013305421452969313,
0.008104882203042507,
-0.0366041474044323,
0.041148729622364044,
0.006805626675486565,
0.010900251567363739,
-0.0007691482896916568,
0.007795535959303379,
0.02486022189259529,
-0.03307196870446205,
-0.004626138601452112,
-0.0005990076460875571,
0.030597196891903877,
-0.0037712170742452145,
0.0031637726351618767,
-0.0032818869221955538,
-0.0008289084653370082,
-0.02344285324215889,
0.05030539259314537,
0.0072218384593725204,
-0.024297773838043213,
-0.016176018863916397,
-0.022464191541075706,
0.0018968575168401003,
0.0022891652770340443,
0.012778829783201218,
0.034196868538856506,
0.012092642486095428,
0.017143430188298225,
0.004527710378170013,
0.043556008487939835,
0.003062532050535083,
0.017525894567370415,
-0.012070144526660442,
-0.019978169351816177,
-0.009134163148701191,
0.02782995067536831,
-0.003937139175832272,
0.008431103080511093,
-0.007300581317394972,
0.021350543946027756,
0.003062532050535083,
0.016997193917632103,
0.026615062728524208,
-0.030934667214751244,
-0.019674448296427727,
-0.0021162123885005713,
-0.03250952064990997,
0.020720601081848145,
0.024927716702222824,
-0.001574855763465166,
-0.00408056378364563,
0.0020205960609018803,
-0.022295458242297173,
-0.023195374757051468,
0.006018198560923338,
-0.004339289851486683,
-0.003785278182476759,
-0.005945080425590277,
-0.017627134919166565,
0.03001224994659424,
0.006366916932165623,
-0.01292506605386734,
0.01974194124341011,
-0.0017928045708686113,
0.002488834550604224,
-0.03565923497080803,
-0.013363775797188282,
-0.024590248242020607,
-0.0010939623462036252,
-0.01654723472893238,
-0.006721259094774723,
-0.003338131820783019,
0.020360635593533516,
-0.020484372973442078,
-0.02702002413570881,
0.013465016148984432,
-0.011496447026729584,
-0.012182634323835373,
-0.013161294162273407,
0.04931548237800598,
-0.009572872892022133,
-0.04132871329784393,
-0.0011572377989068627,
0.022970395162701607,
-0.03689661994576454,
-0.0006837264518253505,
0.022160470485687256,
-0.04112623259425163,
0.022869154810905457,
0.030979663133621216,
-0.004541771486401558,
-0.004249298479408026,
0.00696873664855957,
-0.016176018863916397,
0.027582474052906036,
-0.018009601160883904,
0.00804863777011633,
0.00789677631109953,
-0.016187267377972603,
-0.02063061110675335,
0.005419190973043442,
0.01680595986545086,
0.004600828513503075,
0.014139954932034016,
-0.0036024826113134623,
0.01083275768905878,
0.018279574811458588,
-0.029922259971499443,
0.0242752768099308,
0.013285033404827118,
0.013982469215989113,
-0.01781836710870266,
0.013386273756623268,
0.02742498740553856,
0.0008717951131984591,
0.01670471951365471,
-0.009207281284034252,
-0.005514807533472776,
-0.0011157571570947766,
-0.020315639674663544,
-0.010264684446156025,
0.03628917410969734,
-0.05107032135128975,
-0.027110015973448753,
0.04310605302453041,
0.03588421270251274,
-0.02342035435140133,
0.023690329864621162,
-0.004249298479408026,
-0.013273783959448338,
-0.0006461126613430679,
-0.021125564351677895,
0.02303788997232914,
0.04506337270140648,
-0.02060811221599579,
0.005838215351104736,
0.025287684053182602,
-0.028909852728247643,
0.009578497149050236,
0.001498925150372088,
0.014657407067716122,
0.0004242970608174801,
0.035591740161180496,
-0.027110015973448753,
-0.005385444033890963,
0.02101307548582554,
-0.01343126967549324,
0.023892810568213463,
0.016772214323282242,
0.013453767634928226,
0.01974194124341011,
-0.01331877987831831,
-0.015062370337545872,
-0.028999842703342438,
-0.007036230526864529,
-0.029562292620539665,
-0.028414897620677948,
-0.028999842703342438,
-0.024747733026742935,
0.009713484905660152,
-0.009134163148701191,
-0.0032481399830430746,
0.011755173094570637,
0.007176842540502548,
0.014162452891469002,
-0.007548058405518532,
-0.021789254620671272,
-0.003650290658697486,
-0.0026870975270867348,
0.014983627013862133,
-0.006181308999657631,
-0.031002160161733627,
0.01984318159520626,
0.02207047864794731,
-0.004955171141773462,
0.014308689162135124,
0.015444835647940636,
0.004825808107852936,
0.03122713975608349,
-0.002051530871540308,
-0.0104671660810709,
0.0037487191148102283,
0.0012078580912202597,
-0.06303922832012177,
-0.004972044378519058,
0.009364767000079155,
0.011389581486582756,
-0.007373699452728033,
-0.027784954756498337,
-0.006288174074143171,
0.013914975337684155,
-0.008914808742702007,
0.003774029202759266,
-0.00007373347762040794,
-0.015096116811037064,
-0.04688570648431778,
-0.0005803765379823744,
0.0058719622902572155,
-0.012970061972737312,
-0.01735715940594673,
-0.00060498365201056,
-0.004530522506684065,
-0.009145412594079971,
0.0018223330844193697,
0.004482714459300041,
-0.04189116135239601,
0.012722584418952465,
-0.010349052026867867,
-0.02103557251393795,
-0.013251286000013351,
0.009179159067571163,
-0.007413071114569902,
-0.006918116472661495,
0.02384781464934349,
0.008172376081347466,
0.02200298383831978,
-0.02362283691763878,
-0.011462699621915817,
0.011597687378525734,
0.015174860134720802,
0.024095293134450912,
0.018110841512680054,
0.03505178913474083,
-0.029359810054302216,
-0.03624418005347252,
-0.02823491394519806,
0.02486022189259529,
-0.03424186259508133,
-0.036401666700839996,
0.022666674107313156,
0.02843739464879036,
-0.042543601244688034,
-0.014387432485818863,
0.010275933891534805,
0.013386273756623268,
-0.0013702651485800743,
0.015973536297678947,
0.033341944217681885,
0.01410620752722025,
-0.015197358094155788,
-0.0007986768614500761,
0.024882720783352852,
0.018999509513378143,
0.03707660362124443,
0.001106617390178144,
0.013420021161437035,
-0.017525894567370415,
0.051160313189029694,
0.04326353594660759,
0.016232263296842575,
-0.004969232250005007,
-0.039956338703632355,
0.018133338540792465,
-0.013082551769912243,
0.00736807519569993,
-0.00008529004117008299,
0.010990243405103683,
0.022182967513799667,
-0.027514979243278503,
0.031204640865325928,
-0.020619360730051994,
-0.02075434848666191,
-0.0014075273647904396,
-0.026727551594376564,
0.018290825188159943,
-0.005329199135303497,
0.025512663647532463,
-0.019696945324540138,
-0.019224489107728004,
-0.00631629629060626,
-0.0027152199763804674,
-0.020686855539679527,
-0.0011192724341526628,
-0.01802084967494011,
-0.02704252302646637,
-0.0018645167583599687,
0.015478582121431828,
-0.009747232310473919,
-0.04648074135184288,
0.01050653774291277,
0.029584789648652077,
-0.01252010278403759,
0.007064352743327618,
-0.014364934526383877,
-0.01586104743182659,
0.026277592405676842,
-0.013892477378249168,
-0.013588755391538143,
0.008110507391393185,
0.013195041567087173,
0.00512671796604991,
-0.006366916932165623,
0.026097608730196953,
0.012677588500082493,
-0.024387765675783157,
-0.0030372217297554016,
-0.03541175648570061,
-0.0025914814323186874,
0.020641859620809555,
-0.00802051555365324,
0.018088342621922493,
0.03291448578238487,
-0.002164020435884595,
0.02217171899974346,
-0.028752366080880165,
-0.006085692439228296,
0.022059230133891106,
-0.013779987581074238,
-0.014409930445253849,
-0.006276925094425678,
-0.02250918745994568,
-0.010045330040156841,
-0.006873120553791523,
0.008588587865233421,
0.0007628207677043974,
0.007733666803687811,
0.014297440648078918,
0.03631167486310005,
-0.009702236391603947,
0.007525560446083546,
0.02324037067592144,
0.04387098178267479,
-0.02722250670194626,
-0.0015973537229001522,
-0.003177833976224065,
-0.013071302324533463,
-0.02402779832482338,
-0.02103557251393795,
0.00841422937810421,
-0.010118448175489902,
0.0035096784122288227,
0.0017042189138010144,
-0.007182467263191938,
0.012801327742636204,
0.009983460418879986,
0.013015057891607285,
-0.0016760964645072818,
-0.0011895785573869944,
-0.02686253935098648,
-0.04927048832178116,
-0.014274942688643932,
0.008397355675697327,
-0.012328870594501495,
-0.014499921351671219,
-0.03946138545870781,
-0.031969573348760605,
0.01604103110730648,
-0.006428786087781191,
0.004229612648487091,
0.008594213053584099,
0.027537478134036064,
-0.017852114513516426,
0.02562515251338482,
-0.02501770853996277,
0.0184033140540123,
-0.028347402811050415,
-0.022194217890501022,
-0.01771712675690651,
0.011445826850831509,
-0.0015931352972984314,
-0.010517786256968975,
-0.04945047199726105,
-0.01579355262219906,
0.014668656513094902,
-0.019190741702914238,
0.015208606608211994,
0.03460182994604111,
-0.0045783305540680885,
-0.0012387927854433656,
-0.039978839457035065,
0.0101128239184618,
-0.022644175216555595,
0.009882220067083836,
0.010292807593941689,
0.002800993388518691,
0.00016926183889154345,
-0.01181141845881939,
-0.004285857547074556,
-0.0031075277365744114,
-0.006659389939159155,
0.016513487324118614,
-0.00931414682418108,
0.026592563837766647,
0.008762947283685207,
0.01483739074319601,
-0.01996692083775997,
0.028009934350848198,
-0.020191900432109833,
0.005436064675450325,
0.004122747574001551,
0.002823491347953677,
0.033566925674676895,
0.022059230133891106,
0.005002979189157486,
0.009398514404892921,
0.0298322681337595,
0.008746073581278324,
-0.0031918950844556093,
0.017705878242850304,
0.0418686643242836,
-0.028302406892180443,
0.013689995743334293,
0.0036980987060815096,
0.005843839608132839,
-0.006749381776899099,
-0.02222796343266964,
-0.004870804026722908,
-0.03808901086449623,
0.008099257946014404,
-0.05431002378463745,
0.023892810568213463,
-0.016131022945046425,
-0.002525393618270755,
0.0036868497263640165,
0.033769406378269196,
-0.027942439541220665,
0.01743590272963047,
-0.0021358979865908623,
0.0004506618424784392,
0.028999842703342438,
-0.015973536297678947,
-0.04042879492044449,
0.007458067033439875,
0.025175193324685097,
0.00573978666216135,
0.015591071918606758,
0.02825741097331047,
-0.017604637891054153,
0.026345087215304375,
-0.030912168323993683,
0.0024733671452850103,
0.043735992163419724,
-0.029944756999611855,
-0.003900580108165741,
0.024567749351263046,
0.004103061743080616,
0.031789589673280716,
0.03388189524412155,
0.037774041295051575,
-0.0015045496402308345,
-0.002969728084281087,
-0.045378342270851135,
-0.006530026905238628,
-0.03160960599780083,
-0.02121555618941784,
0.11311963945627213,
-0.03565923497080803,
0.0008781226933933794,
0.02542267180979252,
0.0050001670606434345,
-0.001621257746592164,
0.03082217648625374,
-0.007536809425801039,
0.010422170162200928,
0.0027025649324059486,
0.01822333037853241,
0.015579822473227978,
0.0059113334864377975,
0.014747398905456066,
0.01872953400015831,
-0.01791960932314396,
0.008251119405031204,
0.007953021675348282,
-0.021080568432807922,
-0.015298598445951939,
0.005548554472625256,
0.017424654215574265,
-0.01761588640511036,
0.023105382919311523,
-0.033769406378269196,
-0.030979663133621216,
-0.01353251002728939,
-0.018594546243548393,
-0.01915699429810047,
-0.01976444013416767,
-0.01562481839209795,
0.019629452377557755,
0.0063219210132956505,
-0.04904550686478615,
0.01842581294476986,
-0.03970886394381523,
-0.01766088232398033,
-0.015152362175285816,
0.010349052026867867,
-0.02111431583762169,
0.01847080886363983,
0.015456084161996841,
0.03158710524439812,
0.026727551594376564,
-0.003326882841065526,
0.01692969910800457,
-0.025737643241882324,
-0.030912168323993683,
0.012463858351111412,
-0.025985119864344597,
0.007936147972941399,
0.007587430067360401,
0.008987926878035069,
0.003917453810572624,
0.002171051222831011,
-0.005084534175693989,
0.008464849554002285,
-0.00574541138485074,
-0.027582474052906036,
-0.04585079848766327,
-0.010512161999940872,
0.016513487324118614,
0.01976444013416767,
-0.022216714918613434,
0.02744748629629612
] | 2024-07-10 | 1 | 38981470 | [
"host immune cells",
"host NK cells",
"donor cells",
"iPSC)-derived CAR NK cells",
"multi-edited induced pluripotent stem cell",
"potential rejection",
"rejection",
"B2M",
"broad clinical implementation",
"adhesion",
"Allogeneic cellular immunotherapies",
"genetic ablation",
"genetic deletion",
"universal immunotherapy",
"the engineered donor cells",
"host natural killer (NK) cells",
"B2M-deficient chimeric antigen receptor",
"T cell-mediated rejection",
"CAR",
"the host immune system",
"CAR) T cells",
"promise",
"face",
"limitations",
"beta-2 microglobulin (B2M) expression",
"CD54",
"CD58",
"microglobulin",
"B2M-deficient and B2M-sufficient settings",
"the host"
] | [
"CAR T cells",
"CD54",
"CD58",
"allogeneic cell therapy",
"hyopimmune",
"iPSC-derived NK cells",
"immune evasion",
"immune synapse",
"natural killer cells"
] | 0 | 10.1016/j.stem.2024.06.011 | [
"Hammer",
"Perica",
"Mbofung",
"van Ooijen",
"Martin",
"Momayyezi",
"Varady",
"Pan",
"Jelcic",
"Groff",
"Abujarour",
"Krokeide",
"Lee",
"Williams",
"Goodridge",
"Valamehr",
"Önfelt",
"Sadelain",
"Malmberg"
] | [
"Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. Electronic address: [email protected].",
"Department of Medicine, Weill Cornell Medical College, New York, NY, USA; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Cell Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.",
"Precision Immunotherapy Alliance, Institute for Cancer Research, University of Oslo, Oslo, Norway; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.",
"Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Precision Immunotherapy Alliance, Institute for Cancer Research, University of Oslo, Oslo, Norway; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Fate Therapeutics, Inc., San Diego, CA, USA.",
"Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.",
"Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Precision Immunotherapy Alliance, Institute for Cancer Research, University of Oslo, Oslo, Norway; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Electronic address: [email protected]."
] | [
"38981470"
] | [] | 11.248124 | 5.583999 |
38980802 | 746 | Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors. | Chimeric antigen receptor (CAR)-based therapies have pioneered synthetic cellular immunity but remain limited in their long-term efficacy. Emerging data suggest that dysregulated CAR-driven T-cell activation causes T-cell dysfunction and therapeutic failure. To re-engage the precision of the endogenous T-cell response, we designed MHC-independent T-cell receptors (miTCR) by linking antibody variable domains to T-cell receptor constant chains. Using predictive modeling, we observed that this standard "cut and paste" approach to synthetic protein design resulted in myriad biochemical conflicts at the hybrid variable-constant domain interface. Through iterative modeling and sequence modifications, we developed structure-enhanced miTCRs which significantly improved receptor-driven T-cell function across multiple tumor models. We found that 41BB costimulation specifically prolonged miTCR T-cell persistence and enabled improved leukemic control in vivo compared with classic CAR T cells. Collectively, we have identified core features of hybrid receptor structure responsible for regulating function. Significance: Improving the durability of engineered T-cell immunotherapies is critical to enhancing efficacy. We used a structure-informed design to evolve improved miTCR function across several models. This work underscores the central role of synthetic receptor structure in T-cell function and provides a framework for improved receptor engineering. | [
0.034492477774620056,
0.020476941019296646,
0.019111018627882004,
0.037034280598163605,
-0.048840589821338654,
-0.006419829558581114,
0.016094114631414413,
0.011461860500276089,
-0.02850618213415146,
0.012245780788362026,
0.0055794911459088326,
-0.01681864634156227,
-0.03817452862858772,
-0.012091372162103653,
0.02273367904126644,
-0.04843675345182419,
0.036915503442287445,
-0.02145090140402317,
0.001766789355315268,
0.018291465938091278,
0.017531301826238632,
0.007952037267386913,
-0.017578812316060066,
0.008159894496202469,
-0.0019627693109214306,
0.00037562832585535944,
0.005068755242973566,
0.009157611057162285,
-0.010998634621500969,
-0.013991784304380417,
0.021237105131149292,
-0.031047983095049858,
-0.010511654429137707,
-0.024087723344564438,
-0.028910018503665924,
0.03463501110672951,
0.01310096587985754,
0.006188217084854841,
-0.01983555033802986,
0.02371951937675476,
0.03857836499810219,
0.01772134192287922,
0.021700330078601837,
0.08855920284986496,
-0.07430611550807953,
-0.02375515177845955,
-0.007845139130949974,
-0.0018707182025536895,
0.015369582921266556,
0.02348196692764759,
-0.027080873027443886,
-0.012720883823931217,
-0.028553692623972893,
0.03311467915773392,
-0.05810509994626045,
0.02864871174097061,
-0.01888534612953663,
0.0038275488186627626,
-0.048270467668771744,
0.035252645611763,
-0.007358158007264137,
-0.003987895790487528,
0.022341718897223473,
-0.006087257526814938,
-0.03940979763865471,
0.022282332181930542,
-0.041547760367393494,
-0.00790452677756548,
0.007756056729704142,
0.03603656589984894,
0.0048222956247627735,
-0.03845959156751633,
-0.002960485639050603,
0.002776383189484477,
0.027746016159653664,
-0.02056008391082287,
-0.009412978775799274,
0.04525356367230415,
0.0011261426843702793,
-0.03653542324900627,
0.028078589588403702,
-0.023220660164952278,
0.019194161519408226,
-0.040621306747198105,
-0.030644144862890244,
0.012542719952762127,
0.019312938675284386,
-0.020417552441358566,
-0.03499133884906769,
0.002843194641172886,
0.0002600075677037239,
0.02166469767689705,
-0.03301966190338135,
0.03962359204888344,
-0.006508911494165659,
-0.0025982195511460304,
-0.053734153509140015,
-0.03722432255744934,
0.01598721742630005,
0.02411147765815258,
0.02444405108690262,
0.007726362906396389,
-0.020037470385432243,
0.0012820358388125896,
0.0136710898950696,
-0.032402027398347855,
-0.029147570952773094,
-0.00217805034480989,
-0.025299236178398132,
-0.02127273753285408,
0.08827414363622665,
-0.021534044295549393,
0.006164461839944124,
0.02491915412247181,
-0.04651258513331413,
-0.045396093279123306,
-0.02677205577492714,
0.021415269002318382,
-0.010713573545217514,
0.019146651029586792,
0.0258456040173769,
0.024265887215733528,
0.07634905725717545,
-0.025394257158041,
-0.011331207118928432,
-0.050836022943258286,
0.06727458536624908,
-0.028933774679899216,
-0.06071816757321358,
-0.020595716312527657,
0.03724807873368263,
0.01685428060591221,
0.026391973719000816,
0.02641572803258896,
-0.051881249994039536,
-0.02174784056842327,
-0.01483509223908186,
0.014276846311986446,
-0.03549019619822502,
-0.026938341557979584,
0.009846510365605354,
-0.01971677504479885,
-0.0009747035219334066,
-0.003450435819104314,
-0.01197853498160839,
-0.03489631786942482,
0.02434903010725975,
0.02363637462258339,
-0.0010088515700772405,
0.04059755429625511,
-0.004409549757838249,
0.033447254449129105,
0.04639381170272827,
-0.0006807335303165019,
-0.01652170717716217,
-0.07026773691177368,
-0.02253176085650921,
0.06523164361715317,
0.015488358214497566,
-0.02760348655283451,
0.0022092291619628668,
0.03304341435432434,
-0.05572958290576935,
-0.008646874688565731,
0.024099601432681084,
-0.01408680435270071,
0.004427366424351931,
0.05306900665163994,
-0.07069533318281174,
-0.003973049111664295,
-0.032520800828933716,
-0.033447254449129105,
-0.06784471124410629,
-0.004204661585390568,
-0.06119326874613762,
-0.005704205483198166,
-0.01894473284482956,
-0.02073824778199196,
-0.029836470261216164,
-0.0036375075578689575,
-0.009169488213956356,
0.01673550345003605,
0.004379855934530497,
0.012958435341715813,
-0.020904533565044403,
-0.015856564044952393,
-0.0451110303401947,
0.034041132777929306,
-0.024990418925881386,
-0.027080873027443886,
-0.02736593410372734,
0.04442213103175163,
0.04007494077086449,
-0.021023308858275414,
-0.022757435217499733,
-0.009591142646968365,
0.02369576320052147,
0.02736593410372734,
-0.009608958847820759,
-0.021367758512496948,
0.02273367904126644,
-0.04848426207900047,
-0.004759938456118107,
-0.0005745777161791921,
-0.01963363215327263,
0.0023547294549643993,
-0.012542719952762127,
0.013956150971353054,
-0.020251266658306122,
0.01063636876642704,
0.04912565276026726,
-0.009549571201205254,
-0.00738785183057189,
0.008563731797039509,
-0.016687992960214615,
-0.030216552317142487,
0.01703244261443615,
0.00028636091155931354,
0.0037325280718505383,
0.01616538129746914,
-0.026700789108872414,
-0.03294839337468147,
-0.006532666739076376,
-0.011770677752792835,
-0.06280861794948578,
0.02655825950205326,
-0.0038720895536243916,
-0.04164278134703636,
-0.019075386226177216,
-0.020809512585401535,
-0.011164921335875988,
-0.0032544557470828295,
0.0442083366215229,
-0.04917316138744354,
-0.033209700137376785,
0.025227971374988556,
0.012198270298540592,
-0.03140430897474289,
0.07753681391477585,
-0.03423117473721504,
-0.002376999706029892,
0.044113315641880035,
0.012459577061235905,
0.004082916770130396,
-0.02088077738881111,
0.014098682440817356,
-0.02111832983791828,
-0.06119326874613762,
0.004801509901881218,
-0.0011981504503637552,
-0.011212431825697422,
-0.02192600443959236,
0.00032236482365988195,
0.009080406278371811,
0.01760256662964821,
0.04682140424847603,
0.012317045591771603,
0.0018781416583806276,
0.008747834712266922,
0.005778440739959478,
-0.026819566264748573,
0.019146651029586792,
-0.0236007422208786,
-0.005867522209882736,
-0.04313935339450836,
0.003741436405107379,
-0.018291465938091278,
0.05102606490254402,
0.02082139067351818,
-0.04150024801492691,
0.03249704837799072,
0.015880318358540535,
0.012061677873134613,
-0.01546460296958685,
-0.03938604146242142,
-0.012780271470546722,
-0.033447254449129105,
0.05748746544122696,
-0.0017296719597652555,
0.02874373272061348,
-0.008106444962322712,
-0.014692560769617558,
0.007506627589464188,
-0.02022751048207283,
-0.0283874049782753,
0.0007545972475782037,
-0.0023012803867459297,
-0.013302884995937347,
0.0008596395491622388,
-0.04727274924516678,
0.016509830951690674,
-0.015262684784829617,
-0.04865054786205292,
-0.04069257527589798,
-0.023862048983573914,
0.031143004074692726,
-0.02781728282570839,
-0.0065207891166210175,
-0.027983568608760834,
0.006710830144584179,
-0.017768852412700653,
0.022246699780225754,
0.012613985687494278,
-0.0304778590798378,
-0.0012330408208072186,
0.014015539549291134,
0.02748470939695835,
-0.04465968534350395,
0.05173872038722038,
0.04993332922458649,
0.02862495742738247,
-0.02736593410372734,
0.022009147331118584,
0.009632714092731476,
-0.025204215198755264,
-0.010755144990980625,
0.0304778590798378,
-0.05986298248171806,
0.025703074410557747,
-0.022032903507351875,
-0.05368664115667343,
0.010274102911353111,
-0.0463225431740284,
-0.007358158007264137,
0.025703074410557747,
-0.021534044295549393,
-0.01368296705186367,
-0.037604402750730515,
-0.005689358804374933,
-0.009591142646968365,
0.0436144582927227,
-0.019111018627882004,
0.04104890301823616,
-0.004177937284111977,
0.01368296705186367,
-0.027532219886779785,
-0.04819920286536217,
0.014787581749260426,
0.032069455832242966,
0.06755965203046799,
-0.022816821932792664,
0.01926542818546295,
-0.05834265053272247,
0.016438564285635948,
0.032045699656009674,
-0.03278210759162903,
0.007055279798805714,
0.016497952863574028,
-0.005926910322159529,
-0.0068355449475348,
0.005255827214568853,
0.007120606489479542,
0.009407039731740952,
-0.04207037389278412,
-0.00558839924633503,
0.021581554785370827,
-0.01586844027042389,
-0.013587946072220802,
-0.009151672013103962,
-0.023743273690342903,
-0.009133855812251568,
0.010018735192716122,
-0.015072643756866455,
0.032520800828933716,
0.04043126851320267,
0.05881775543093681,
-0.0334710069000721,
0.044089559465646744,
-0.013576068915426731,
-0.053021498024463654,
-0.022175433114171028,
0.026249442249536514,
0.004240294452756643,
0.028102343901991844,
-0.030691655352711678,
0.024147111922502518,
0.03218822926282883,
0.007126545533537865,
0.0412389412522316,
-0.033898599445819855,
0.0325683131814003,
-0.0060694413259625435,
-0.021819107234477997,
-0.05691734328866005,
0.022306086495518684,
0.007726362906396389,
0.02480037696659565,
-0.02237735316157341,
-0.09402288496494293,
0.040502533316612244,
-0.03301966190338135,
-0.03304341435432434,
0.009074468165636063,
-0.0004739894939120859,
-0.01200822927057743,
0.030810430645942688,
-0.023410702124238014,
0.0612407810986042,
0.062143474817276,
0.029765203595161438,
-0.01466880552470684,
-0.025536786764860153,
-0.04275927320122719,
-0.03351851925253868,
0.009418917819857597,
-0.008468711748719215,
0.03399362042546272,
0.012471454218029976,
0.05121610686182976,
0.011289635673165321,
0.017400648444890976,
-0.03161810711026192,
0.02841116115450859,
0.032639577984809875,
0.017851995304226875,
-0.03988489881157875,
-0.05648975074291229,
0.033447254449129105,
0.03489631786942482,
0.025560542941093445,
0.02383829466998577,
-0.0439232736825943,
0.02527548000216484,
-0.02348196692764759,
-0.0032544557470828295,
0.018125180155038834,
0.029242591932415962,
0.008177710697054863,
0.019574245437979698,
-0.049790795892477036,
-0.05572958290576935,
0.0746861919760704,
0.017816362902522087,
-0.0319744348526001,
-0.020512573421001434,
0.03907722234725952,
-0.011022389866411686,
0.0020444276742637157,
-0.035276398062705994,
0.007756056729704142,
-0.014300600625574589,
0.016426686197519302,
-0.017543179914355278,
-0.039148490875959396,
0.01667611673474312,
0.03292464092373848,
0.013635456562042236,
-0.00913979485630989,
-0.001775697572156787,
-0.0011016451753675938,
-0.031831901520490646,
-0.008403385058045387,
0.012590230442583561,
0.02420649863779545,
-0.00640201335772872,
-0.006841483525931835,
0.05330656096339226,
-0.06447148323059082,
0.017578812316060066,
0.0355614610016346,
0.03415990620851517,
-0.03128553554415703,
0.022519882768392563,
-0.02377890609204769,
-0.005163776222616434,
0.05762999504804611,
0.05648975074291229,
-0.05601464584469795,
-0.01026222575455904,
-0.0648515596985817,
0.00595363462343812,
-0.04356694594025612,
0.006592054385691881,
0.02044130675494671,
-0.0069958921521902084,
0.027912301942706108,
0.03095296211540699,
-0.010511654429137707,
0.01604660414159298,
-0.02058383822441101,
-0.00036337957135401666,
-0.024277765303850174,
-0.010642307810485363,
0.008551854640245438,
0.0033732315059751272,
0.030287817120552063,
-0.03294839337468147,
-0.01768570952117443,
-0.0018291466403752565,
0.05254639312624931,
0.02231796458363533,
-0.026106910780072212,
-0.017709465697407722,
-0.010274102911353111,
0.01546460296958685,
-0.014680683612823486,
0.00451941741630435,
-0.007269076071679592,
-0.0273421797901392,
0.023945191875100136,
0.020429430529475212,
0.03237827122211456,
-0.020726369693875313,
0.034254927188158035,
0.045277319848537445,
0.0567748099565506,
0.05192876234650612,
0.028434915468096733,
-0.006675197277218103,
0.03919599950313568,
-0.03059663437306881,
-0.010879859328269958,
0.02276931330561638,
-0.011467799544334412,
-0.0053360010497272015,
-0.03363729268312454,
-0.028696222230792046,
-0.012020106427371502,
0.004896530415862799,
0.003024327801540494,
0.013777988031506538,
-0.006687074899673462,
-0.006568299140781164,
0.012400188483297825,
0.014051171950995922,
-0.025299236178398132,
-0.04223665967583656,
-0.03898220136761665,
-0.05834265053272247,
-0.0472014844417572,
-0.002967909211292863,
0.00048029946628957987,
0.03268708661198616,
0.04893561080098152,
0.0053449091501533985,
-0.024610336869955063,
-0.020215634256601334,
0.03266333416104317,
-0.02279306761920452,
-0.030406594276428223,
0.026605769991874695,
-0.012174515053629875,
0.035181377083063126,
-0.01772134192287922,
0.0067702182568609715,
0.033684805035591125,
-0.016355421394109726,
-0.021854739636182785,
0.03318594768643379,
0.024942908436059952,
0.03190316632390022,
-0.035252645611763,
0.01084422692656517,
-0.01361170131713152,
-0.005727960728108883,
-0.057107385247945786,
0.0065445443615317345,
-0.05359162017703056,
0.0048935613594949245,
-0.02458658069372177,
-0.01320786401629448,
-0.028363650664687157,
-0.0014483218546956778,
-0.013718599453568459,
-0.03294839337468147,
0.005255827214568853,
-0.00787483248859644,
-0.030287817120552063,
-0.025536786764860153,
0.029717694967985153,
-0.0010897675529122353,
-0.0340648852288723,
0.026914585381746292,
-0.02864871174097061,
0.029622673988342285,
0.014383744448423386,
-0.029955245554447174,
0.009763367474079132,
0.02288808859884739,
0.023493845015764236,
-0.03651166707277298,
-0.025940624997019768,
0.012542719952762127,
0.05843767151236534,
-0.028434915468096733,
0.018683426082134247,
-0.04534858465194702,
-0.05283145606517792,
0.007298770360648632,
0.030905451625585556,
-0.016331667080521584,
0.0004268503689672798,
0.008741895668208599,
0.00208451459184289,
-0.019883060827851295,
0.012376434169709682,
-0.007079035043716431,
0.012530841864645481,
-0.029028795659542084,
-0.0009591142297722399,
0.019764285534620285,
0.01616538129746914,
0.006621748208999634,
-0.043994538486003876,
-0.04546735808253288,
0.04344817250967026,
-0.0027808374725282192,
0.015702154487371445,
-0.04525356367230415,
-0.006485156249254942,
0.027912301942706108,
0.03822203725576401,
0.008854732848703861,
0.02655825950205326,
-0.0161297470331192,
0.021712208166718483,
-0.021462779492139816,
-0.017293749377131462,
0.015512113459408283,
-0.020750124007463455,
-0.014348111115396023,
-0.009329835884273052,
-0.007791689597070217,
0.010547286830842495,
0.014799458906054497,
-0.04556237906217575,
-0.02082139067351818,
0.003492007264867425,
-0.0014750463888049126,
0.011895392090082169,
0.011693472974002361,
-0.02446780540049076,
-0.03589403256773949,
0.03798448666930199,
-0.012376434169709682,
-0.03244953602552414,
0.02088077738881111,
0.01827958971261978,
-0.012649618089199066,
-0.008747834712266922,
-0.030549123883247375,
-0.02482413314282894,
-0.011824126355350018,
-0.01165190152823925,
0.025703074410557747,
-0.005849706009030342,
-0.035775259137153625,
0.026273196563124657,
0.00787483248859644,
-0.02641572803258896,
-0.0177807305008173,
-0.00881316140294075,
0.026273196563124657,
-0.014134314842522144,
0.026819566264748573,
0.0005393161554820836,
0.010363184846937656,
0.0069661978632211685,
0.05919783562421799,
0.03337598592042923,
-0.00787483248859644,
0.02537050098180771,
-0.02294747531414032,
-0.02572682872414589,
-0.005006398074328899,
0.02655825950205326,
0.029361367225646973,
0.005858614109456539,
-0.006152584217488766,
-0.0057814097963273525,
0.0633312314748764,
0.021344004198908806,
0.004653040319681168,
0.010274102911353111,
-0.0067880344577133656,
0.014051171950995922,
0.02967018447816372,
-0.028791243210434914,
-0.0325683131814003,
0.0008462772821076214,
0.0015901104779914021,
0.024776622653007507,
-0.04777161031961441,
-0.08110008388757706,
0.0077382405288517475,
0.008991324342787266,
-0.010060306638479233,
0.006134768016636372,
-0.004468937870115042,
0.0010392878903076053,
-0.01466880552470684,
0.016533585265278816,
-0.024420294910669327,
-0.020476941019296646,
0.011675656773149967,
-0.0023784844670444727,
0.01772134192287922,
-0.007643220014870167,
0.0018439936684444547,
-0.019134774804115295,
0.0379369780421257,
0.024657847359776497,
0.004958887584507465,
-0.003076292108744383,
0.015583379194140434,
0.006413890980184078,
-0.014217457734048367,
-0.009359529241919518,
-0.016212889924645424,
0.03907722234725952,
-0.0015871410723775625,
0.004071039147675037,
0.010470082983374596,
-0.024776622653007507,
-0.014181825332343578,
0.01356419175863266,
-0.005986297968775034,
0.061715882271528244,
0.014906357042491436,
0.03149932995438576,
-0.019099142402410507,
0.0074650561437010765,
-0.022341718897223473,
0.012542719952762127,
0.04663136228919029,
0.020001837983727455,
-0.013754232786595821,
0.04615625739097595,
-0.016260400414466858,
0.013884886167943478,
-0.022899966686964035,
-0.012002290226519108,
-0.01804203726351261,
0.011188676580786705,
-0.0013095027534291148,
0.019384203478693962,
-0.007150300312787294,
-0.0462987907230854,
-0.006312931422144175,
-0.004774785600602627,
0.009074468165636063,
-0.021260859444737434,
-0.02769850566983223,
0.026368217542767525,
0.001450548879802227,
0.027532219886779785,
0.03130928799510002,
0.01774509809911251,
0.0403362475335598,
-0.023434456437826157,
-0.0032960271928459406,
0.008807222358882427,
-0.032045699656009674,
0.001459457096643746,
0.006479217670857906,
-0.017495669424533844,
0.014181825332343578,
0.004005712457001209,
-0.025061683729290962,
-0.004261080175638199,
-0.025418011471629143,
0.029171325266361237,
-0.001734126009978354,
0.0012939133448526263,
0.007328464183956385,
-0.004718367010354996,
0.006122890394181013,
0.004929193761199713,
-0.0016643452690914273,
0.03503884747624397,
-0.0006009311182424426,
-0.025465521961450577,
-0.02943263202905655,
-0.03501509130001068,
0.003699864726513624,
0.007352219428867102,
-0.0180776696652174,
0.006407951936125755,
-0.03035908378660679,
0.022876210510730743,
0.01425309106707573,
-0.017341259866952896,
-0.01361170131713152,
-0.01574966497719288,
-0.018802201375365257,
-0.017792608588933945,
-0.014158070087432861,
0.026059400290250778,
-0.005190500523895025,
-0.03758065029978752,
0.00085073133232072,
0.016082236543297768,
-0.03223574161529541,
0.007993608713150024,
-0.010481960140168667,
0.03271084278821945,
0.027746016159653664,
-0.09350027143955231,
-0.01484696939587593,
0.02099955454468727,
0.0033227517269551754,
0.000041246737964684144,
0.012839659117162228,
0.00154260010458529,
-0.028577446937561035,
-0.01784011907875538,
-0.025132950395345688,
-0.0343499481678009,
0.0009301626123487949,
0.029622673988342285,
0.012328923679888248,
0.022781189531087875,
-0.0036285994574427605,
-0.035775259137153625,
-0.03420741856098175,
-0.0206194706261158,
0.027437198907136917,
0.003468252019956708,
0.01535770483314991,
-0.0007315844413824379,
0.012364556081593037,
-0.026819566264748573,
0.0023443365935236216,
-0.01786387339234352,
0.010345368646085262,
-0.04287804663181305,
-0.025798093527555466,
-0.010719511657953262,
0.024752868339419365,
-0.015607134439051151,
0.040977634489536285,
-0.02446780540049076,
-0.028601201251149178,
0.022864332422614098,
-0.0273421797901392,
0.007144361734390259,
0.006111012771725655,
0.010915491729974747,
-0.013041578233242035,
0.029836470261216164,
0.015761543065309525,
-0.019740531221032143,
-0.04126269742846489,
-0.005472593009471893,
-0.01234080083668232,
-0.014063049107789993,
-0.005110326688736677,
0.02088077738881111,
-0.01592782884836197,
-0.023743273690342903,
0.04116767644882202,
-0.023553231731057167,
-0.020785756409168243,
0.005413204897195101,
0.03337598592042923,
0.04090636968612671,
0.015690278261899948,
-0.017875751480460167,
0.045158542692661285,
0.03339974209666252,
-0.014169947244226933,
0.030169041827321053,
-0.015120153315365314,
-0.011277757585048676,
0.030810430645942688,
-0.011824126355350018,
0.026011889800429344,
0.00823116023093462,
0.04019371420145035,
-0.055587053298950195,
0.0067405239678919315,
0.005166745278984308,
0.02073824778199196,
-0.027389688417315483,
-0.01368296705186367,
-0.004157151561230421,
0.026724545285105705,
0.013195986859500408,
-0.0015559623716399074,
0.024515315890312195,
0.008130200207233429,
-0.03133304417133331,
-0.011806310154497623,
-0.022626781836152077,
0.027104627341032028,
0.01924167200922966,
0.013635456562042236,
-0.008391506969928741,
0.015642767772078514,
0.0016984932590276003,
-0.01339790504425764,
-0.011610330082476139,
-0.01525080669671297,
-0.017436280846595764,
-0.0015307225985452533,
-0.0020800605416297913,
-0.006877116393297911,
0.057107385247945786,
-0.008688446134328842,
0.012613985687494278,
-0.04715397581458092,
-0.03845959156751633,
-0.007589770946651697,
-0.022187311202287674,
-0.00553495017811656,
0.015500236302614212,
0.017127463594079018,
0.0057814097963273525,
0.02864871174097061,
0.018125180155038834,
-0.013587946072220802,
0.018410243093967438,
-0.002841709880158305,
0.030311573296785355,
-0.02722340263426304,
-0.009098222479224205,
0.009276386350393295,
0.05055096000432968,
0.03881591558456421,
-0.013599824160337448,
-0.025132950395345688,
-0.012257657945156097,
0.017555056139826775,
0.02282870002090931,
0.007975791580975056,
0.02339882403612137,
-0.03639288991689682,
0.025204215198755264,
-0.012994067743420601,
0.013623579405248165,
0.005433990620076656,
-0.02184286154806614,
0.04546735808253288,
0.019918695092201233,
0.04753405600786209,
0.0026190055068582296,
0.02208041213452816,
0.014276846311986446,
0.013920518569648266,
0.005944726523011923,
-0.03988489881157875,
0.025916870683431625,
-0.025679318234324455,
-0.06418641656637192,
0.023173149675130844,
-0.023410702124238014,
0.010464143939316273,
0.0036879873368889093,
0.040407512336969376,
0.029646428301930428,
0.02480037696659565,
-0.02324441634118557,
0.02306625247001648,
0.010648246854543686,
-0.027104627341032028,
-0.0158328078687191,
0.015322072431445122,
-0.051976270973682404,
0.06575425714254379,
-0.0026605769526213408,
-0.011254003271460533,
0.023054374381899834,
-0.012400188483297825,
-0.013089088723063469,
0.005160806700587273,
0.008290547877550125,
0.03613158315420151,
0.016141625121235847,
-0.08988948911428452,
0.06589678674936295,
-0.007079035043716431,
-0.055824603885412216,
0.021367758512496948,
0.03187941387295723,
0.05278394743800163,
0.011770677752792835,
0.03233076259493828,
-0.021355880424380302,
0.01607036031782627,
0.028102343901991844,
0.034373704344034195,
0.023885805159807205,
-0.0306203905493021,
0.004774785600602627,
-0.01983555033802986,
0.01310096587985754,
0.014324355870485306,
0.0008447925793007016,
-0.019491100683808327,
0.008789406158030033,
0.0355614610016346,
0.014645050279796124,
-0.0012233903398737311,
-0.017495669424533844,
0.033209700137376785,
-0.033542271703481674,
-0.03513386845588684,
-0.043186865746974945,
0.01455003023147583,
0.027437198907136917,
-0.010873920284211636,
-0.010119694285094738,
-0.004133396316319704,
0.008462772704660892,
-0.02772226184606552,
-0.009899958968162537,
0.04176155477762222,
0.004670856520533562,
0.04945822432637215,
-0.0038988140877336264,
0.022579271346330643,
-0.008949752897024155,
-0.00266651576384902,
0.017543179914355278,
-0.004629285074770451,
-0.022056657820940018,
-0.012317045591771603,
-0.014110559597611427,
-0.023410702124238014,
0.006437645759433508,
0.007666975259780884,
-0.014395621605217457,
0.0089616309851408,
0.016806770116090775,
0.03544268384575844,
0.01026222575455904,
0.010012796148657799,
-0.0340648852288723,
0.017495669424533844,
-0.015559623949229717,
-0.01106990035623312,
-0.0011714259162545204,
-0.005362725351005793,
0.0012760970275849104,
-0.029195081442594528,
0.008539976552128792,
-0.02805483341217041,
0.04071632772684097,
0.011224308982491493,
-0.003459343919530511,
-0.026486992835998535,
-0.02115396223962307,
0.0006391620263457298,
0.05539701133966446,
0.003901783609762788,
-0.016391053795814514,
-0.014609417878091335,
-0.016414809972047806,
0.028149854391813278,
0.020488817244768143,
0.019918695092201233,
0.053496599197387695,
0.03594154492020607,
-0.000812871556263417,
0.04047877714037895,
0.021260859444737434,
0.014407498762011528,
-0.000042290663259336725,
-0.009531754069030285,
0.020203756168484688,
-0.004454090725630522,
0.04416082426905632,
-0.05610966682434082,
0.009050712920725346,
0.016201013699173927,
-0.005487440153956413,
0.0031030166428536177,
0.022603025659918785,
0.001616835012100637,
-0.0005352332373149693,
0.00000945914325711783,
0.007470995187759399,
0.000803963397629559,
0.018956610932946205,
-0.027033362537622452,
-0.002474989742040634,
-0.01455003023147583,
-0.02145090140402317,
0.006912748795002699,
-0.029005039483308792,
0.010226592421531677,
0.027650995180010796,
0.002216652501374483,
-0.01789950579404831,
0.005935818422585726,
0.02276931330561638,
-0.0010726934997364879,
-0.0045877136290073395,
-0.008658752776682377,
-0.01953861117362976,
-0.03420741856098175,
-0.012376434169709682,
-0.03755689412355423,
0.006877116393297911,
0.0019523764494806528,
-0.0015871410723775625,
-0.014419376850128174,
0.011675656773149967,
0.04518229886889458,
0.0012271020095795393,
-0.026344463229179382,
0.032402027398347855,
-0.034611254930496216,
-0.013849252834916115,
-0.02969393879175186,
0.05891277641057968,
-0.005217225290834904,
-0.03990865498781204,
-0.013979906216263771,
0.0062891761772334576,
-0.0030272970907390118,
0.011194614693522453,
0.0013273190706968307,
-0.005567613523453474,
-0.0023784844670444727,
0.0035068541765213013,
0.01768570952117443,
-0.03095296211540699,
0.024610336869955063,
0.02643948420882225,
-0.017531301826238632,
-0.009894020855426788,
0.005042030941694975,
0.00640201335772872,
-0.027793526649475098,
0.015262684784829617,
0.01756693422794342,
0.006378258112818003,
-0.0009190274286083877,
0.007672913838177919,
-0.02046506293118,
0.0001319524453720078,
0.026962095871567726,
-0.008183649741113186,
-0.022686168551445007,
0.011847881600260735,
-0.005232071969658136,
-0.0003542858175933361,
-0.012602107599377632,
-0.0000673681206535548,
0.013920518569648266,
-0.012720883823931217,
-0.001533692004159093,
0.009074468165636063,
0.008896304294466972,
-0.034706275910139084,
-0.039694856852293015,
0.05264141410589218,
-0.019229795783758163,
-0.02888626419007778,
0.036012809723615646,
-0.006704891566187143,
-0.03373231366276741,
-0.006099135149270296,
0.017163095995783806,
-0.022460496053099632,
-0.007340341806411743,
-0.02712838351726532,
0.03684423863887787,
0.03247329220175743,
-0.013195986859500408,
-0.012174515053629875,
0.02213980071246624,
-0.03845959156751633,
-0.004638193175196648,
0.005490409210324287,
0.02190225012600422,
0.006728646345436573,
0.009911837056279182,
-0.01870718225836754,
-0.005754685495048761,
-0.012590230442583561,
0.01033942960202694,
0.03558521717786789,
0.010214715264737606,
0.0019286213209852576,
0.005647787358611822,
-0.012352678924798965,
-0.007459117565304041,
-0.008587487041950226,
0.0014765311498194933,
-0.012121065519750118,
-0.013184108771383762,
-0.03872089460492134,
-0.0033969865180552006,
0.009199182502925396,
-0.012127004563808441,
-0.00794609822332859,
-0.020334409549832344,
0.026510749012231827,
-0.004287804942578077,
-0.0343499481678009,
-0.0031030166428536177,
-0.0007404926000162959,
-0.004783693701028824,
-0.0038602121639996767,
-0.015084520913660526,
-0.04603748396039009,
-0.0050479695200920105,
0.024847887456417084,
-0.027555976063013077,
0.01592782884836197,
0.012388311326503754,
0.01310096587985754,
0.019217917695641518,
-0.008343996480107307,
0.017246238887310028,
0.006586115807294846,
-0.01483509223908186,
-0.04487347975373268,
0.015595256350934505,
-0.03199818730354309,
0.011640024371445179,
0.008480588905513287,
-0.012495209462940693,
-0.005980359390377998,
-0.005309276282787323,
0.007506627589464188,
-0.0337560698390007,
-0.014051171950995922,
0.01810142584145069,
0.0027303576935082674,
0.0019568304996937513,
0.02560805343091488,
0.010624491609632969,
-0.028316140174865723,
0.0027689598500728607,
0.003931477665901184,
-0.005938787944614887,
-0.023280048742890358,
-0.00951393786817789,
-0.048840589821338654,
0.0361553393304348,
0.01263774000108242,
0.011164921335875988,
-0.008011424914002419,
0.020310653373599052,
0.001558931777253747,
0.014431254006922245,
0.03952857106924057,
0.03185565769672394,
0.0030391747131943703,
-0.02434903010725975,
0.0035632727667689323,
-0.015013255178928375,
0.017935140058398247,
0.03142806515097618,
0.002408178523182869,
0.02103518694639206,
-0.011604391038417816,
-0.03325721248984337,
-0.04264049604535103,
0.008225221186876297,
-0.022282332181930542,
-0.04370947927236557,
0.008539976552128792,
0.020393798127770424,
-0.03653542324900627,
-0.004768846556544304,
0.0035721808671951294,
0.03653542324900627,
-0.00277489866130054,
0.014122437685728073,
-0.008189588785171509,
-0.012827781960368156,
-0.017068076878786087,
-0.0158328078687191,
0.02028689906001091,
0.014621295966207981,
0.010897675529122353,
0.000011616593837970868,
0.01908726431429386,
-0.016117870807647705,
0.010778900235891342,
0.020726369693875313,
-0.0004082916711922735,
-0.03415990620851517,
-0.04489723592996597,
-0.002895158948376775,
-0.0025566481053829193,
-0.0007148815784603357,
0.0005883111734874547,
0.0003589254920370877,
-0.006663320120424032,
-0.05207129195332527,
0.01766195520758629,
-0.002317611826583743,
0.008569670841097832,
0.001351074199192226,
-0.016296032816171646,
-0.001037060865201056,
-0.009407039731740952,
-0.012566475197672844,
0.0056032463908195496,
0.031119247898459435,
-0.01624852418899536,
-0.015761543065309525,
-0.024158988147974014,
0.008819099515676498,
0.00791640393435955,
-0.034254927188158035,
-0.004994520451873541,
0.012388311326503754,
-0.029765203595161438,
-0.035181377083063126,
-0.0001438300241716206,
0.008973508141934872,
-0.014158070087432861,
-0.0068117897026240826,
-0.03266333416104317,
0.022211065515875816,
0.06380633264780045,
-0.03753313794732094,
-0.008011424914002419,
0.019467346370220184,
-0.008332119323313236,
-0.01535770483314991,
0.024847887456417084,
0.024182744324207306,
0.042592987418174744,
-0.00009613412839826196,
-0.01669987104833126,
-0.024990418925881386,
-0.007346280384808779,
0.014870724640786648,
0.004872775170952082,
0.006378258112818003,
0.03862587735056877,
0.0010608159936964512,
0.024871643632650375,
0.0017445188714191318,
-0.021593432873487473,
0.04463592916727066,
-0.031475573778152466,
-0.009537693113088608,
-0.0024645968805998564,
-0.0069899531081318855,
-0.025465521961450577,
0.006419829558581114,
0.012138882651925087,
-0.009840571321547031,
0.008462772704660892,
0.02213980071246624,
-0.012388311326503754,
-0.0005445125862024724,
-0.021557800471782684,
0.012364556081593037,
0.037058036774396896,
-0.013694844208657742,
0.004421427380293608,
0.004195753484964371,
-0.028672467917203903,
-0.03178439289331436,
-0.0069661978632211685,
0.004344223067164421,
0.006865238770842552,
-0.007399729453027248,
0.01993057131767273,
-0.0022121984511613846,
0.009205121546983719,
0.004492693115025759,
0.005128143355250359,
-0.0019226825097575784,
-0.015690278261899948,
-0.027175892144441605,
-0.023280048742890358,
-0.007316586561501026,
-0.023612620308995247,
-0.005362725351005793,
-0.021070819348096848,
0.017163095995783806,
-0.008943814784288406,
0.003049567574635148,
0.03938604146242142,
0.003993834834545851,
-0.01607036031782627,
0.013302884995937347,
-0.01697305589914322,
0.02862495742738247,
-0.03537141904234886,
0.02109457366168499,
-0.021914126351475716,
-0.027508465573191643,
-0.029290100559592247,
0.029147570952773094,
0.011230248026549816,
0.02458658069372177,
-0.05439929664134979,
0.0006699694786220789,
0.03492007404565811,
0.00431749876588583,
0.00738785183057189,
0.023885805159807205,
-0.0005823723622597754,
0.012613985687494278,
-0.04093012586236,
0.001183303422294557,
-0.004881683737039566,
0.03318594768643379,
0.0009197697509080172,
-0.0025625869166105986,
0.0004777012509293854,
-0.04812793806195259,
0.015072643756866455,
-0.015191419050097466,
-0.015037010423839092,
0.0033465069718658924,
-0.01466880552470684,
0.011539064347743988,
-0.022175433114171028,
-0.006675197277218103,
-0.004457060247659683,
0.012756516225636005,
-0.04216539487242699,
-0.00299166445620358,
-0.023018741980195045,
0.014930112287402153,
0.032615821808576584,
0.021248983219265938,
-0.03202194347977638,
-0.000623201543930918,
0.0279360581189394,
-0.007880771532654762,
-0.015678400173783302,
-0.0027852915227413177,
0.05216631293296814,
-0.03014528751373291,
0.0028446794021874666,
0.00424920255318284,
-0.006817728281021118,
-0.021937882527709007,
0.008260853588581085,
-0.01906350813806057,
-0.02154592238366604,
0.013089088723063469,
-0.017020566388964653,
0.01977616362273693,
0.009222937747836113,
0.025893114507198334,
0.0038691202644258738,
0.027793526649475098,
-0.024515315890312195,
-0.002452719258144498,
-0.0077382405288517475,
-0.00010661980195436627,
0.009531754069030285,
0.008985386230051517,
-0.006479217670857906,
0.03572774678468704,
0.014502519741654396,
-0.017365016043186188,
0.024634091183543205,
0.015025133267045021,
-0.009151672013103962,
0.02769850566983223,
-0.018362732604146004,
0.004163090139627457,
0.02103518694639206,
-0.0035870277788490057,
0.010066245682537556,
0.019550489261746407,
0.019170407205820084,
-0.026249442249536514,
0.020714491605758667,
0.03629787266254425,
-0.01795889437198639,
0.019075386226177216,
-0.03035908378660679,
-0.006229788530617952,
-0.02781728282570839,
0.012661495245993137,
0.12153135240077972,
-0.007589770946651697,
0.0003739580570254475,
0.018517140299081802,
-0.010862043127417564,
0.000332386523950845,
0.010470082983374596,
-0.0136710898950696,
0.014526274986565113,
0.0030465980526059866,
0.019217917695641518,
-0.015571502037346363,
0.00039864113205112517,
0.031071737408638,
0.04228416830301285,
-0.0005894246860407293,
0.001112780417315662,
0.022781189531087875,
-0.010576981119811535,
0.02056008391082287,
-0.0006762794801034033,
0.01139653380960226,
-0.00827866978943348,
0.014407498762011528,
-0.005858614109456539,
-0.020726369693875313,
0.0036196911241859198,
-0.021700330078601837,
0.017875751480460167,
-0.012875291518867016,
0.018517140299081802,
0.018837835639715195,
0.001345877768471837,
-0.018659671768546104,
-0.009567387402057648,
-0.022721802815794945,
-0.005918002221733332,
-0.03396986797451973,
0.005861583631485701,
-0.011111471801996231,
0.01723436266183853,
0.04950573667883873,
0.029290100559592247,
0.01760256662964821,
0.010725450702011585,
0.03579901158809662,
-0.016058482229709625,
0.018778447061777115,
0.006063502281904221,
-0.0016465289518237114,
0.00733440276235342,
-0.005362725351005793,
-0.00011125947639811784,
-0.03822203725576401,
-0.007934220135211945,
0.00001306069316342473,
0.039243508130311966,
-0.01211512740701437,
-0.029860224574804306,
-0.038103263825178146,
-0.022009147331118584,
0.014431254006922245,
0.010838287882506847,
-0.019562367349863052,
0.02772226184606552
] | 2024-07-09 | 47 | 38980802 | [
"classic CAR T cells",
"synthetic receptor structure",
"hybrid receptor structure",
"improved receptor engineering",
"Chimeric antigen receptor",
"improved miTCR function",
"T-cell receptor constant chains",
"synthetic protein design",
"synthetic cellular immunity",
"T-cell function",
"improved leukemic control",
"miTCR T-cell persistence",
"receptor-driven T-cell function",
"engineered T-cell immunotherapies",
"function",
"MHC-independent T-cell receptors",
"antibody variable domains",
"myriad biochemical conflicts",
"CAR-driven T-cell activation",
"predictive modeling",
"T-cell dysfunction and therapeutic failure",
"CAR)-based therapies",
"multiple tumor models",
"the endogenous T-cell response",
"several models",
"core features",
"structure-enhanced miTCRs",
"Emerging data",
"efficacy",
"iterative modeling and sequence modifications"
] | [] | 0 | 10.1158/2159-8290.CD-23-1393 | [
"Chang",
"Landmann",
"Chang",
"Selli",
"Tenzin",
"Warrington",
"Ritchey",
"Hsu",
"Slade",
"Gupta",
"DiPersio",
"Holehouse",
"Singh"
] | [
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri.",
"Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Biomolecular Condensates, Washington University School of Medicine, St. Louis, Missouri.",
"Division of Oncology, Section of Cellular Therapy, Washington University School of Medicine, St. Louis, Missouri.\nCenter for Gene and Cellular Immunotherapy, Washington University School of Medicine, St. Louis, Missouri."
] | [
"38980802",
"34861191",
"37130030",
"29713085",
"33020644",
"29440406",
"31802004",
"33795428",
"27959684",
"35484264",
"35648703",
"30076299",
"31064990",
"37501016",
"2513569",
"2528411",
"33762437",
"35027758",
"31461748",
"29490423",
"25950237",
"34265844",
"38718835",
"29155426",
"33888899",
"32811512",
"36867678",
"26738796",
"35190680",
"15057788",
"17947658",
"36607811",
"26461090",
"18424733",
"31575864",
"29212954",
"37055515",
"28506444",
"29808005",
"29808007",
"29880584",
"34893771",
"20122868",
"18496571",
"35690611",
"15264254",
"32029687"
] | [] | 8.833182 | 4.818945 |
38980672 | 747 | Understanding CAR-T therapy in myeloma: 1 cell at a time. | null | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-09 | 8 | 38980672 | [] | [] | 0 | 10.1182/bloodadvances.2024013292
10.1182/bloodadvances.2023011242 | [
"Dhodapkar"
] | [
"Department of Hematology/Oncology, Emory University, Atlanta, GA."
] | [
"38980672",
"38574299",
"36026513",
"37592106",
"38564776",
"37907724",
"38324393",
"37526080"
] | [] | 33.024197 | 7.457835 |
38980259 | 748 | STING-Activating Small Molecular Therapeutics for Cancer Immunotherapy. | Immuno-oncology has become a revolutionary strategy for cancer treatment. Therapeutic interventions based on adaptive immunity through immune checkpoint therapy or chimeric antigen receptor (CAR) T cells have received clinical approval for monotherapy and combination treatment in various cancers. Although these treatments have achieved clinical successes, only a minority of cancer patients show a response, highlighting the urgent need to discover new therapeutic molecules that could be exploited to improve clinical outcomes and pave the way for the next generation of immunotherapy. Given the critical role of the innate immune system against infection and cancer, substantial efforts have been dedicated to developing novel anticancer therapeutics that target these pathways. Targeting the stimulator of interferon genes (STING) pathway is a powerful strategy to generate a durable antitumor response, and activation of the adaptor protein STING induces the initiation of transcriptional cascades, thereby producing type I interferons, pro-inflammatory cytokines and chemokines. Various STING agonists, including natural or synthetic cyclic dinucleotides (CDNs), have been developed as anticancer therapeutics. However, since most CDNs are confined to intratumoral administration, there has been a great interest in developing non-nucleotide agonists for systemic treatment. Here, we review the current development of STING-activating therapeutics in both preclinical and clinical stages. | [
0.01966794952750206,
0.011224637739360332,
0.022472647950053215,
0.04592694342136383,
-0.06474179774522781,
0.004794281907379627,
0.010003425180912018,
0.025335779413580894,
-0.017833208665251732,
-0.003202031133696437,
0.023664645850658417,
-0.011557696387171745,
0.006351474206894636,
-0.02267131395637989,
0.025616249069571495,
-0.015647882595658302,
0.021011868491768837,
-0.0061995526775717735,
0.0067663355730473995,
0.06385364383459091,
0.04422074928879738,
-0.0067429631017148495,
-0.023220568895339966,
-0.01120710838586092,
-0.0028938064351677895,
-0.011201265268027782,
-0.026668010279536247,
0.04695533215999603,
0.0041047935374081135,
0.0067663355730473995,
0.0019632892217487097,
-0.02837420254945755,
-0.03403034433722496,
-0.0029084142297506332,
-0.004171989392489195,
0.003581834025681019,
0.00955350510776043,
0.0009772622724995017,
0.006158650852739811,
-0.005448711570352316,
0.012691262178122997,
0.011528480798006058,
0.025102054700255394,
0.060441259294748306,
-0.048007093369960785,
-0.022098688408732414,
-0.00035734346602112055,
-0.04997038096189499,
0.009319780394434929,
-0.04125244542956352,
-0.013041849248111248,
-0.012960045598447323,
-0.009284721687436104,
0.06235780194401741,
-0.037466101348400116,
0.037185631692409515,
-0.02888839691877365,
0.022215550765395164,
-0.04908222705125809,
-0.005822671577334404,
0.0022685923613607883,
-0.013567729853093624,
0.014794785529375076,
-0.012095263227820396,
-0.029776550829410553,
0.03309544548392296,
-0.018370777368545532,
-0.006374846678227186,
-0.00016196405340451747,
0.001969132339581847,
0.026948479935526848,
-0.003742519998922944,
-0.004484596662223339,
0.047749996185302734,
0.015425843186676502,
0.007368177175521851,
-0.030057022348046303,
0.04429086670279503,
-0.009015938267111778,
-0.015367412008345127,
0.03907880187034607,
0.004233342129737139,
0.010938324965536594,
-0.024307388812303543,
-0.01364953350275755,
0.0020932985935360193,
-0.01680481992661953,
-0.014210473746061325,
-0.07913924753665924,
-0.01387157291173935,
-0.015390784479677677,
0.018148738890886307,
-0.04045777767896652,
0.01438576728105545,
-0.031786587089300156,
-0.001214639050886035,
-0.0035555399954319,
-0.03608712553977966,
0.035643044859170914,
0.04001370072364807,
0.03255787864327431,
-0.03424069657921791,
-0.023314058780670166,
-0.008221273310482502,
0.03445104882121086,
0.012562713585793972,
-0.015986783429980278,
-0.0037629709113389254,
0.058992162346839905,
-0.008747153915464878,
0.07825109362602234,
0.01083314884454012,
-0.06104894354939461,
0.015741372480988503,
-0.01802019029855728,
-0.06137615814805031,
-0.02292841300368309,
0.004838105291128159,
0.014409139752388,
0.012574399821460247,
-0.035830024629831314,
0.022799864411354065,
0.004680341109633446,
0.009477544575929642,
0.0018420442938804626,
-0.04485180601477623,
0.058524712920188904,
-0.021093672141432762,
-0.006497552152723074,
-0.058805182576179504,
0.031880076974630356,
0.003497108817100525,
0.010424130596220493,
-0.00855433102697134,
-0.03961636871099472,
-0.012480909004807472,
-0.0139884352684021,
0.02746267430484295,
-0.031506117433309555,
0.003403618698939681,
0.023360803723335266,
-0.04954967647790909,
-0.0145493745803833,
-0.0007256427779793739,
-0.010389071889221668,
-0.08358002454042435,
-0.018627874553203583,
0.02288166806101799,
0.025195544585585594,
0.04718905687332153,
-0.03473151847720146,
0.03910217434167862,
0.08297234028577805,
0.04440772905945778,
0.00583143625408411,
-0.002736042020842433,
-0.022776491940021515,
0.04384678974747658,
-0.011516794562339783,
-0.011008442379534245,
-0.014537688344717026,
0.010850678198039532,
-0.024447623640298843,
-0.00995083712041378,
0.013427495025098324,
0.002464336808770895,
-0.012083576992154121,
0.018195483833551407,
-0.03248776122927666,
0.019329048693180084,
-0.00009504203626420349,
-0.03475489094853401,
-0.054972097277641296,
0.009045153856277466,
-0.03276823088526726,
-0.02168967016041279,
-0.007613588590174913,
0.0032283251639455557,
-0.01710866205394268,
0.0033627168741077185,
0.002627944340929389,
0.029472708702087402,
0.031880076974630356,
-0.031856704503297806,
0.009325623512268066,
0.031950194388628006,
-0.025499386712908745,
0.01657109521329403,
-0.03316556289792061,
-0.003237089840695262,
-0.010622796602547169,
0.008028450421988964,
0.02776651829481125,
0.04090185835957527,
-0.015729686245322227,
-0.007747980300337076,
0.026130443438887596,
-0.0067312768660485744,
0.013369063846766949,
-0.017961759120225906,
0.042444441467523575,
-0.041836757212877274,
-0.02776651829481125,
-0.03239427134394646,
-0.04616066813468933,
-0.02893514186143875,
-0.004879007115960121,
0.06460156291723251,
-0.0007292947266250849,
0.04090185835957527,
0.022332413122057915,
-0.02022888883948326,
0.03886844962835312,
0.01624388061463833,
0.0036811670288443565,
0.009524289518594742,
0.0025753562804311514,
-0.01799681782722473,
0.047726623713970184,
0.02823396772146225,
0.021210534498095512,
-0.004432008136063814,
-0.011697931215167046,
0.022753119468688965,
0.004522576928138733,
0.007753823418170214,
-0.03335254266858101,
-0.030547844246029854,
0.013147025369107723,
0.000892536947503686,
-0.024985190480947495,
0.0016945054521784186,
0.0145493745803833,
-0.031178900972008705,
-0.06427434831857681,
-0.00036976009141653776,
-0.0008757379837334156,
-0.012761379592120647,
0.03335254266858101,
-0.011773891746997833,
0.015776431187987328,
-0.007420765236020088,
0.011762205511331558,
0.00905684009194374,
-0.06852813810110092,
0.02842094749212265,
0.007490883115679026,
-0.06128266826272011,
-0.01915375515818596,
-0.02187664993107319,
-0.019586145877838135,
0.03272148594260216,
0.030617961660027504,
0.0021122887264937162,
0.005837279371917248,
-0.03426406905055046,
0.037209004163742065,
0.0014067316660657525,
0.015916666015982628,
0.010412444360554218,
0.024915073066949844,
0.030010277405381203,
-0.04150954261422157,
-0.04644113779067993,
-0.07053817063570023,
-0.005057222209870815,
0.004119401331990957,
0.03316556289792061,
0.01703854463994503,
-0.005460397806018591,
0.019492655992507935,
0.030945176258683205,
0.03505873307585716,
-0.009454172104597092,
-0.024494368582963943,
0.014046866446733475,
0.01962120458483696,
0.0556265264749527,
-0.006684531923383474,
0.04438435658812523,
-0.012223811820149422,
-0.036881789565086365,
-0.025195544585585594,
0.014783099293708801,
-0.03251113370060921,
0.00423042057082057,
0.005428260657936335,
-0.03547943755984306,
0.00023792464344296604,
-0.03452116623520851,
0.010254680179059505,
0.013158711604773998,
-0.015601136721670628,
0.010576051659882069,
-0.022706374526023865,
0.018277287483215332,
-0.007000060752034187,
-0.015542705543339252,
0.00022258644457906485,
0.029659688472747803,
-0.012971731834113598,
-0.014561060816049576,
0.017634542658925056,
-0.017073603346943855,
-0.00694747269153595,
-0.008560174144804478,
-0.01175636239349842,
-0.043028753250837326,
0.03776994347572327,
0.03412383422255516,
0.06904233247041702,
-0.03288509324193001,
0.010120287537574768,
0.024026919156312943,
0.025733111426234245,
0.030617961660027504,
0.03547943755984306,
-0.06282525509595871,
0.0031377568375319242,
-0.022472647950053215,
-0.03879833221435547,
0.041860129684209824,
0.006620257627218962,
0.004820575937628746,
0.0273925568908453,
-0.029636316001415253,
0.07287542521953583,
-0.031155528500676155,
0.00811025407165289,
-0.0290052592754364,
0.008186214603483677,
0.012258870527148247,
0.05011061578989029,
0.0037746571470052004,
-0.01104350108653307,
-0.011072716675698757,
-0.03473151847720146,
-0.06848139315843582,
0.027065342292189598,
0.025803228840231895,
-0.053850214928388596,
0.019445911049842834,
-0.025476014241576195,
0.04094860330224037,
0.04141605272889137,
0.005939533933997154,
-0.03463802859187126,
0.04174326732754707,
-0.0041164797730743885,
0.025990208610892296,
0.029355846345424652,
0.036835044622421265,
0.017213838174939156,
0.02311539277434349,
0.0037308335304260254,
0.024190526455640793,
-0.016863251104950905,
-0.03982672095298767,
0.01957445964217186,
-0.02011202648282051,
-0.0027842477429658175,
-0.028350830078125,
-0.018277287483215332,
0.05067155882716179,
0.030197257176041603,
0.003733755322173238,
-0.04618404060602188,
-0.023267313838005066,
-0.017634542658925056,
-0.02771977335214615,
0.014771413058042526,
0.06806068867444992,
-0.020263947546482086,
0.017120348289608955,
-0.010096915066242218,
0.07502569258213043,
0.020824888721108437,
0.023980174213647842,
0.0572158545255661,
0.04912897199392319,
0.043122243136167526,
-0.0034299127291888,
-0.001482692314311862,
-0.007718764711171389,
-0.048194073140621185,
0.0552058219909668,
0.035713162273168564,
-0.03290846571326256,
-0.07507243752479553,
0.020147085189819336,
0.018627874553203583,
-0.0580572634935379,
0.029963532462716103,
0.015940038487315178,
-0.013228829018771648,
0.05043783411383629,
-0.023173823952674866,
0.07320263981819153,
0.0573093444108963,
0.0015221333596855402,
-0.00003754662611754611,
-0.0273925568908453,
-0.026340795680880547,
-0.026854990050196648,
0.02034575305879116,
-0.030501099303364754,
0.0287715345621109,
0.042093854397535324,
0.059740085154771805,
-0.048007093369960785,
-0.015332353301346302,
0.018101993948221207,
0.03255787864327431,
-0.012773065827786922,
0.011306441389024258,
-0.020941751077771187,
-0.026901734992861748,
0.004122322890907526,
0.023664645850658417,
0.022051943466067314,
0.0048147328197956085,
-0.0274393018335104,
0.01762285642325878,
-0.04031754285097122,
-0.0030676391907036304,
0.0047796741127967834,
0.032067056745290756,
-0.0138014554977417,
0.020976809784770012,
-0.0573560893535614,
-0.0287715345621109,
0.09489230811595917,
-0.002271513920277357,
-0.01675807498395443,
-0.0569353848695755,
0.029636316001415253,
-0.009086055681109428,
-0.0008224194752983749,
-0.014783099293708801,
0.01156938262283802,
-0.04412725940346718,
0.018382463604211807,
-0.06058149412274361,
-0.029612943530082703,
0.019749753177165985,
0.03949950635433197,
-0.0014016189379617572,
0.011867381632328033,
0.04513227567076683,
-0.03812053054571152,
-0.008010921068489552,
-0.05076504871249199,
0.006135278381407261,
0.008875702507793903,
-0.01943422481417656,
-0.0291454941034317,
0.05169994756579399,
-0.052868571132421494,
0.00869456585496664,
0.018137052655220032,
0.025662994012236595,
-0.03269811347126961,
-0.016372429206967354,
-0.03501198813319206,
-0.05198041722178459,
0.0272990670055151,
-0.012749693356454372,
0.002506699413061142,
0.009162016212940216,
-0.016010155901312828,
0.012574399821460247,
-0.048755012452602386,
-0.059646591544151306,
0.009214604273438454,
0.017026858404278755,
0.013228829018771648,
0.04964316636323929,
-0.01678144745528698,
0.008034293539822102,
0.021011868491768837,
0.005667828489094973,
0.031996939331293106,
-0.021981826052069664,
-0.0013986973790451884,
0.03374987468123436,
0.012212125584483147,
-0.035689789801836014,
-0.01694505475461483,
-0.0034386776387691498,
-0.011610284447669983,
0.018791481852531433,
-0.030571216717362404,
0.04950293153524399,
-0.009892405942082405,
-0.008519272319972515,
-0.017868267372250557,
0.0016988877905532718,
0.03620398789644241,
-0.05118575319647789,
0.003380246227607131,
-0.0037629709113389254,
0.07119259983301163,
0.0011196882696822286,
0.0013957758201286197,
0.06997723132371902,
0.03966311365365982,
0.036367595195770264,
0.014806471765041351,
0.010260523296892643,
-0.012866555713117123,
-0.006117749027907848,
-0.026410913094878197,
0.030430981889367104,
-0.01773971877992153,
-0.03241764381527901,
0.0015265156980603933,
-0.02313876524567604,
0.015285608358681202,
0.014023493975400925,
-0.01792670041322708,
-0.0013205456780269742,
0.015297294594347477,
0.010587737895548344,
0.007315589115023613,
0.008922447450459003,
-0.03286172077059746,
-0.031319137662649155,
-0.0016127018025144935,
-0.024611230939626694,
-0.058758437633514404,
-0.0011883450206369162,
-0.031132156029343605,
0.0068773552775382996,
0.036461085081100464,
-0.018756423145532608,
-0.022075315937399864,
-0.0289117693901062,
0.02006528154015541,
-0.01910701021552086,
-0.029355846345424652,
-0.0012854869710281491,
0.01962120458483696,
0.026551147922873497,
-0.004879007115960121,
-0.013743024319410324,
0.06128266826272011,
-0.030617961660027504,
0.007555157411843538,
0.011715460568666458,
-0.0016711329808458686,
0.01992504671216011,
-0.01769297383725643,
-0.001536741154268384,
-0.008443311788141727,
0.03267474099993706,
0.014818158000707626,
-0.026457658037543297,
-0.014397453516721725,
-0.0145026296377182,
0.020930064842104912,
-0.02893514186143875,
-0.031319137662649155,
0.0033042856957763433,
-0.02232072688639164,
0.05113900825381279,
0.014818158000707626,
-0.007508412469178438,
0.0008012381731532514,
-0.01971469447016716,
0.04071487858891487,
-0.0058285146951675415,
-0.012375732883810997,
-0.014981766231358051,
0.00348542258143425,
0.03339928761124611,
0.02718220464885235,
-0.021841591224074364,
-0.001300825155340135,
-0.03606375306844711,
0.01922387257218361,
0.0038330883253365755,
-0.01908363774418831,
-0.005390280392020941,
0.03452116623520851,
-0.00002791460428852588,
0.024003546684980392,
-0.019445911049842834,
0.0017865346744656563,
0.01896677538752556,
-0.0009597328607924283,
0.004890693351626396,
-0.01123048085719347,
0.047703251242637634,
-0.011861538514494896,
-0.017494307830929756,
-0.005574338603764772,
0.008770526386797428,
0.006310572382062674,
-0.01715540699660778,
0.019258931279182434,
0.007654490415006876,
-0.00898672267794609,
-0.019188813865184784,
-0.037442728877067566,
-0.026177188381552696,
-0.004823497496545315,
-0.014420825988054276,
-0.029472708702087402,
0.026153815910220146,
-0.0071052368730306625,
0.02814047783613205,
-0.014806471765041351,
-0.020053595304489136,
0.00030530313961207867,
0.02020551636815071,
0.01097338367253542,
-0.006976688280701637,
0.012983418069779873,
-0.001595172449015081,
-0.009676210582256317,
-0.006678688805550337,
0.0010846295626834035,
-0.031436000019311905,
0.005968749523162842,
-0.002693679416552186,
-0.04987689107656479,
-0.011148677207529545,
-0.04527251049876213,
0.020147085189819336,
0.012364046648144722,
-0.004502126015722752,
-0.03816727548837662,
-0.03466140106320381,
0.012796438299119473,
-0.0017543975263834,
-0.0544578991830349,
0.015542705543339252,
-0.0004086533735971898,
0.0058168284595012665,
0.004341439809650183,
0.00474169384688139,
0.006421591620892286,
0.0005879641976207495,
-0.014444198459386826,
0.026130443438887596,
-0.0027564929332584143,
-0.0274393018335104,
-0.025709738954901695,
0.0012832958018407226,
-0.018814854323863983,
-0.001906318706460297,
-0.004423243459314108,
0.011008442379534245,
-0.037045396864414215,
0.03421732410788536,
0.008303076960146427,
-0.005954141728579998,
-0.024611230939626694,
0.04167314991354942,
0.04662811756134033,
-0.014000121504068375,
0.010681227780878544,
0.00044699886348098516,
0.007455823943018913,
0.0013913934817537665,
0.01750599406659603,
0.005007555708289146,
0.030127139762043953,
0.011557696387171745,
0.009565191343426704,
0.07923273742198944,
0.02236747182905674,
0.04064476117491722,
0.009237976744771004,
-0.0287715345621109,
0.03856460750102997,
0.012387419119477272,
-0.026808245107531548,
-0.021268965676426888,
-0.0033276581671088934,
0.0026177188847213984,
0.011551853269338608,
-0.025476014241576195,
-0.06319921463727951,
0.02225060947239399,
-0.0138482004404068,
0.02197013981640339,
0.003865225473418832,
-0.0038915195036679506,
-0.020731398835778236,
0.013591102324426174,
-0.025102054700255394,
-0.02055610530078411,
-0.026995224878191948,
0.01978481188416481,
0.022729746997356415,
-0.009419113397598267,
0.014420825988054276,
-0.05212065204977989,
-0.014409139752388,
0.020976809784770012,
0.0052851042710244656,
-0.005051379092037678,
-0.0281171053647995,
0.006170337088406086,
0.012691262178122997,
-0.012492595240473747,
-0.03274485841393471,
0.037115514278411865,
0.031272392719984055,
-0.029379218816757202,
0.005361064802855253,
-0.002164876786991954,
0.00576131884008646,
-0.01680481992661953,
-0.003061796072870493,
0.0014388689305633307,
0.021152103319764137,
0.017354073002934456,
-0.024961818009614944,
-0.0007720225257799029,
0.008127783425152302,
0.016325684264302254,
0.014724668115377426,
0.05020410940051079,
0.05141947790980339,
-0.06404062360525131,
0.03253450617194176,
-0.01138240285217762,
0.009845660999417305,
-0.01908363774418831,
-0.025639621540904045,
-0.01889665797352791,
-0.02050936035811901,
-0.0033860893454402685,
0.02180653251707554,
-0.048240818083286285,
-0.006573512684553862,
-0.00848421361297369,
-0.006801394280046225,
0.042561303824186325,
-0.0575898140668869,
-0.036694809794425964,
0.010500091128051281,
0.002887963317334652,
-0.011808950453996658,
0.002790090860798955,
-0.01177973486483097,
0.031622979789972305,
-0.04031754285097122,
0.01622050814330578,
0.00811025407165289,
-0.013976749032735825,
-0.0024132095277309418,
0.04115895554423332,
-0.0273458119481802,
-0.0049111442640423775,
-0.009068526327610016,
-0.01132397074252367,
-0.04136930778622627,
-0.02220386452972889,
-0.0015148294623941183,
0.009086055681109428,
0.005869416519999504,
0.008116097189486027,
0.04714231193065643,
-0.00004352669566287659,
0.05198041722178459,
-0.024634603410959244,
0.029893415048718452,
-0.015741372480988503,
-0.02083657495677471,
0.001766083762049675,
-0.035666417330503464,
-0.02055610530078411,
0.01668795756995678,
-0.020918378606438637,
-0.04083174094557762,
-0.001855191309005022,
0.011651186272501945,
0.04064476117491722,
-0.014046866446733475,
-0.012375732883810997,
-0.0026966009754687548,
0.009214604273438454,
0.002841218374669552,
-0.008817271329462528,
0.029706433415412903,
-0.00037049048114567995,
-0.01156938262283802,
-0.00964699499309063,
0.04099534824490547,
-0.014619491994380951,
0.03992021083831787,
-0.009220447391271591,
0.018160425126552582,
0.018031876534223557,
-0.09358344972133636,
-0.014163728803396225,
-0.011177892796695232,
0.025476014241576195,
-0.03959299623966217,
0.010722129605710506,
-0.0064917090348899364,
0.01042997371405363,
0.03473151847720146,
-0.0061644939705729485,
-0.01135903038084507,
-0.03332917019724846,
0.023746449500322342,
-0.024003546684980392,
0.018756423145532608,
-0.02253107912838459,
-0.0041047935374081135,
-0.059132397174835205,
-0.00590155366808176,
0.04545949399471283,
0.030851686373353004,
-0.009898249059915543,
-0.02362958714365959,
0.04066813364624977,
0.005252967122942209,
-0.00474169384688139,
0.006941629573702812,
0.007712921593338251,
-0.025499386712908745,
-0.04978340119123459,
-0.04573996365070343,
0.01802019029855728,
-0.0141754150390625,
0.036390967667102814,
0.035666417330503464,
-0.048194073140621185,
0.004727086052298546,
0.020591164007782936,
0.008431625552475452,
-0.012469222769141197,
0.029355846345424652,
0.000006042838322173338,
0.029589571058750153,
0.01797344535589218,
-0.04723580181598663,
-0.03545606508851051,
-0.019422538578510284,
-0.005498378071933985,
0.017050230875611305,
-0.02718220464885235,
0.022449275478720665,
-0.0288650244474411,
-0.030524471774697304,
-0.014374081045389175,
-0.007619431708008051,
-0.0014293738640844822,
-0.003581834025681019,
0.05277508124709129,
0.025546131655573845,
0.019025206565856934,
-0.017751405015587807,
0.004963732324540615,
-0.0021634160075336695,
-0.006006729789078236,
0.027041969820857048,
0.0020597006659954786,
-0.024821583181619644,
0.04333259537816048,
-0.016091959550976753,
-0.004992947913706303,
0.015180432237684727,
-0.004472909960895777,
-0.06665834039449692,
0.03449779376387596,
0.01757611148059368,
-0.008478370495140553,
0.0013103202218189836,
-0.012819810770452023,
-0.015390784479677677,
0.01980818435549736,
-0.015379098244011402,
0.009080212563276291,
0.017821522429585457,
0.018499325960874557,
-0.010465032421052456,
-0.00488192867487669,
-0.0290052592754364,
0.011645343154668808,
-0.024774838238954544,
-0.0002941646962426603,
0.03865809738636017,
-0.031085411086678505,
0.00850758608430624,
-0.0032633838709443808,
-0.003070560749620199,
-0.006409905385226011,
-0.022005198523402214,
0.007239628583192825,
0.009758014231920242,
0.00555680925026536,
0.0551123321056366,
-0.01811368018388748,
-0.04401039704680443,
-0.019188813865184784,
-0.021175475791096687,
0.03830751031637192,
-0.02088331989943981,
0.031552862375974655,
0.009980052709579468,
0.018277287483215332,
0.015273922123014927,
-0.024097036570310593,
0.0069241002202034,
-0.018382463604211807,
-0.01182647980749607,
0.015273922123014927,
0.017167093232274055,
0.0064917090348899364,
0.00953013263642788,
-0.0028981887735426426,
0.04681509733200073,
-0.00020943941490259022,
-0.03793355077505112,
-0.000962654419708997,
-0.005930769257247448,
-0.01764622889459133,
0.04674497991800308,
-0.005115653853863478,
-0.010237150825560093,
-0.017728032544255257,
-0.024891700595617294,
0.001350491656921804,
0.03875158727169037,
0.0001294616813538596,
-0.008823114447295666,
0.03863472491502762,
0.03300195559859276,
0.02175978757441044,
-0.02718220464885235,
0.00476506631821394,
0.0068598254583776,
-0.02727569453418255,
-0.006643630098551512,
-0.007198726758360863,
0.017798149958252907,
0.0035263244062662125,
-0.032090429216623306,
0.00020542227139230818,
0.011446677148342133,
0.002348935231566429,
-0.02227398194372654,
0.013509298674762249,
0.011318127624690533,
0.04898873716592789,
-0.018709678202867508,
0.030173884704709053,
0.015951724722981453,
-0.011218794621527195,
-0.021467631682753563,
-0.004011303652077913,
-0.002195553155615926,
0.01717877946794033,
-0.03360963985323906,
0.009109428152441978,
-0.013404122553765774,
0.012551027350127697,
0.009898249059915543,
-0.01945759728550911,
0.042561303824186325,
0.007695392239838839,
0.015402470715343952,
-0.04410388693213463,
0.029472708702087402,
-0.035619672387838364,
-0.04389353469014168,
-0.012293929234147072,
0.03234752640128136,
0.04062138870358467,
0.026060326024889946,
0.026364168152213097,
-0.02175978757441044,
0.020240575075149536,
0.04052789509296417,
0.03505873307585716,
0.03314219042658806,
-0.037092141807079315,
-0.006369003560394049,
-0.009243819862604141,
-0.011651186272501945,
-0.04333259537816048,
0.02299853041768074,
0.002313876524567604,
0.016512664034962654,
0.026901734992861748,
0.003754206234589219,
-0.024354133754968643,
-0.025756483897566795,
0.011318127624690533,
-0.01894340291619301,
-0.014864902943372726,
-0.019656263291835785,
-0.0006310571916401386,
0.05067155882716179,
-0.0038827548269182444,
-0.021864963695406914,
0.007508412469178438,
0.007829784415662289,
-0.042841773480176926,
-0.016103645786643028,
0.03360963985323906,
0.006328101735562086,
0.012375732883810997,
-0.02832745760679245,
0.02206362970173359,
0.012317301705479622,
0.002525689546018839,
0.018183797597885132,
-0.01750599406659603,
-0.05085853859782219,
0.013252201490104198,
0.0278366357088089,
-0.03510547801852226,
-0.015016824938356876,
0.007514255587011576,
-0.04524913802742958,
0.026013581082224846,
0.04370655491948128,
0.018101993948221207,
-0.013462553732097149,
0.012410791590809822,
-0.0016360742738470435,
0.02211037464439869,
0.04066813364624977,
0.025546131655573845,
0.013193770311772823,
0.0022569061256945133,
0.021350769326090813,
-0.004843948408961296,
0.03889182209968567,
-0.0008779291529208422,
0.04356632009148598,
0.03244101628661156,
-0.004721242934465408,
-0.04616066813468933,
-0.019469283521175385,
-0.011557696387171745,
0.042724911123514175,
-0.026691382750868797,
-0.009413270279765129,
-0.009991738945245743,
-0.005892788991332054,
0.0018814854556694627,
0.02302190288901329,
0.016255566850304604,
0.030267374590039253,
0.02006528154015541,
0.009343152865767479,
-0.01976143941283226,
0.013462553732097149,
0.010914952494204044,
0.03952287882566452,
-0.02248433418571949,
-0.022379158064723015,
0.02353609725832939,
0.0020319458562880754,
-0.0007771352538838983,
-0.0284910649061203,
-0.01952771469950676,
0.012188753113150597,
0.004525498487055302,
0.021549435332417488,
-0.011464206501841545,
0.007163668051362038,
-0.01994841918349266,
-0.0013986973790451884,
-0.009606093168258667,
0.0065150815062224865,
0.008992565795779228,
-0.024330761283636093,
-0.021888336166739464,
0.0002731659624259919,
0.009226290509104729,
0.002122514182701707,
0.015308980830013752,
-0.011142834089696407,
0.004794281907379627,
-0.0273925568908453,
-0.013485926203429699,
0.01901352033019066,
-0.015659568831324577,
0.0007289295317605138,
-0.009617779403924942,
-0.029846668243408203,
-0.02360621467232704,
-0.005162398796528578,
-0.03608712553977966,
-0.008688722737133503,
0.0031143841333687305,
0.007666176650673151,
-0.007525941822677851,
0.008016764186322689,
0.05076504871249199,
-0.03241764381527901,
0.012013459578156471,
0.008893231861293316,
-0.002014416502788663,
-0.03281497582793236,
-0.03447442129254341,
0.06352642923593521,
-0.009039310738444328,
-0.04134593531489372,
0.014771413058042526,
0.01734238676726818,
0.001501682447269559,
-0.013228829018771648,
-0.0014352169819176197,
-0.005898632109165192,
0.016033528372645378,
0.0008662429172545671,
-0.004598537459969521,
-0.013252201490104198,
0.00478843878954649,
-0.008869859389960766,
0.010967540554702282,
-0.031950194388628006,
-0.019726380705833435,
0.010126130655407906,
-0.005647377576678991,
-0.01138240285217762,
-0.018569443374872208,
0.031646352261304855,
-0.03358626738190651,
-0.005679515190422535,
-0.015776431187987328,
0.010961697436869144,
0.014724668115377426,
-0.009220447391271591,
-0.00683645298704505,
0.005846044048666954,
-0.01424553245306015,
-0.014140356332063675,
0.007625274825841188,
-0.00033214499126188457,
0.00362565740942955,
0.007859000004827976,
0.007257157936692238,
0.005916161462664604,
-0.0014257219154387712,
0.008162842132151127,
-0.017856581136584282,
0.047773368656635284,
0.004697870463132858,
-0.01612701825797558,
0.047539643943309784,
0.04094860330224037,
-0.01917712762951851,
0.00820374395698309,
-0.0007172432960942388,
-0.005150712560862303,
0.013906631618738174,
0.0012014920357614756,
0.01002095453441143,
0.003015051130205393,
0.0058402009308338165,
-0.004747536964714527,
0.011557696387171745,
-0.006170337088406086,
0.019375793635845184,
0.013158711604773998,
0.002433660440146923,
-0.012913300655782223,
0.042467813938856125,
-0.06544297188520432,
0.01659446768462658,
0.001890250132419169,
0.020357439294457436,
0.05216739699244499,
0.0024862485006451607,
-0.002223307965323329,
0.02032238058745861,
0.02278817817568779,
-0.009489230811595917,
-0.01396506279706955,
0.009541818872094154,
0.0065384539775550365,
-0.018803168088197708,
-0.025476014241576195,
-0.008939976803958416,
-0.013941690325737,
0.03585340082645416,
-0.015425843186676502,
-0.010283895768225193,
0.007987548597157001,
-0.00903346762061119,
-0.01894340291619301,
0.011586911976337433,
-0.008957506157457829,
-0.012726320885121822,
-0.004677419550716877,
0.02741592936217785,
-0.04954967647790909,
-0.013684592209756374,
0.03816727548837662,
-0.0009816446108743548,
0.025429269298911095,
0.0004064622044097632,
-0.00217364146374166,
0.027065342292189598,
-0.01085652131587267,
0.0036694807931780815,
-0.005469162482768297,
-0.00957687757909298,
-0.03856460750102997,
0.03826076537370682,
-0.024634603410959244,
0.010862364433705807,
0.01950434222817421,
-0.007187040522694588,
-0.02355946972966194,
-0.005729181692004204,
0.020427556708455086,
-0.008630291558802128,
0.01009107194840908,
0.003914892207831144,
-0.018405836075544357,
0.022869981825351715,
0.00019793577666860074,
0.019492655992507935,
-0.02823396772146225,
0.008688722737133503,
0.04132256284356117,
0.001955985324457288,
-0.001695966231636703,
-0.019188813865184784,
-0.031763214617967606,
0.0291454941034317,
0.011037657968699932,
-0.016255566850304604,
-0.024844955652952194,
0.009676210582256317,
-0.0046598901972174644,
-0.012889928184449673,
0.04361306503415108,
0.017003485932946205,
-0.008186214603483677,
-0.0288650244474411,
0.016793133690953255,
0.002211621729657054,
0.0000045649394451174885,
0.008612762205302715,
0.02320888265967369,
0.03405371680855751,
-0.006579355802386999,
-0.026714755222201347,
-0.03821402043104172,
0.0073564909398555756,
-0.04438435658812523,
0.013976749032735825,
0.011534323915839195,
0.013427495025098324,
-0.029449336230754852,
-0.005550966132432222,
0.026247305795550346,
0.023804880678653717,
-0.01387157291173935,
-0.005659063812345266,
-0.021607866510748863,
0.0018391227349638939,
-0.021467631682753563,
-0.037372611463069916,
-0.003391932463273406,
0.014537688344717026,
-0.006550140213221312,
0.007000060752034187,
0.03816727548837662,
-0.015940038487315178,
0.025265661999583244,
0.025803228840231895,
0.02339586243033409,
0.006363160442560911,
0.016185449436306953,
-0.008384880609810352,
-0.010798090137541294,
0.02206362970173359,
-0.002084533916786313,
0.016278939321637154,
-0.0036607161164283752,
-0.03468477353453636,
0.059272632002830505,
0.0284443199634552,
-0.0071578249335289,
0.0034240696113556623,
-0.019819870591163635,
-0.0141754150390625,
0.001141600077971816,
0.04931595176458359,
-0.00836735125631094,
-0.006725433748215437,
-0.00578469131141901,
0.017517680302262306,
0.007561000529676676,
0.009606093168258667,
-0.0000876924823387526,
0.012492595240473747,
-0.004852713085711002,
0.007859000004827976,
-0.04471157118678093,
-0.0581507533788681,
-0.012340674176812172,
0.005340613890439272,
-0.01771634630858898,
-0.0037600493524223566,
-0.0006858364795334637,
0.007718764711171389,
0.037185631692409515,
0.019726380705833435,
-0.027135459706187248,
0.032020311802625656,
0.013754710555076599,
-0.013076907955110073,
-0.02243758924305439,
0.02874816209077835,
0.01738913170993328,
-0.023910056799650192,
0.0030442667193710804,
-0.010581894777715206,
-0.027486048638820648,
-0.0009334388305433095,
0.002011494943872094,
0.008875702507793903,
0.015718000009655952,
-0.0039061272982507944,
0.019188813865184784,
-0.010412444360554218,
-0.014490943402051926,
0.023804880678653717,
-0.03819064795970917,
-0.009489230811595917,
-0.01013781689107418,
-0.00985734723508358,
-0.0142689049243927,
-0.023150451481342316,
-0.009559348225593567,
-0.015157059766352177,
0.019726380705833435,
0.01797344535589218,
0.012773065827786922,
-0.012515967711806297,
0.010576051659882069,
0.015063569881021976,
0.008466684259474277,
0.017283955588936806,
-0.015998469665646553,
-0.015495960600674152,
0.00002691031841095537,
-0.0029478552751243114,
0.02215711958706379,
-0.001969132339581847,
-0.017073603346943855,
0.013158711604773998,
0.0004813272098544985,
-0.009407427161931992,
0.021339083090424538,
0.015180432237684727,
0.01111361850053072,
-0.007730450946837664,
-0.03529245778918266,
-0.0285378098487854,
-0.03917229175567627,
-0.013789769262075424,
-0.008057666011154652,
-0.01645423285663128,
0.0008669733069837093,
0.024260643869638443,
0.006415748503059149,
-0.0026600814890116453,
-0.001346839708276093,
0.03321230784058571,
0.025195544585585594,
-0.0010926638497039676,
0.006509238388389349,
0.005933690816164017,
-0.018288973718881607,
-0.016325684264302254,
-0.018160425126552582,
-0.001229977235198021,
-0.031786587089300156,
0.017657915130257607,
0.0059366123750805855,
-0.004919908940792084,
-0.05179343745112419,
-0.024821583181619644,
0.030173884704709053,
-0.010733815841376781,
0.012609458528459072,
0.020006850361824036,
-0.019913360476493835,
0.02355946972966194,
-0.027088714763522148,
0.012691262178122997,
0.022262295708060265,
0.0569821298122406,
-0.006602728273719549,
0.01750599406659603,
0.018312346190214157,
-0.007449980825185776,
0.004218734335154295,
-0.0034006971400231123,
-0.04069150611758232,
0.0012759919045493007,
-0.060534749180078506,
0.03318893536925316,
-0.0018581128679215908,
0.0020319458562880754,
-0.0032809132244437933,
0.0276029109954834,
-0.036928534507751465,
0.021035240963101387,
-0.01438576728105545,
0.012223811820149422,
0.0274393018335104,
0.03335254266858101,
-0.017494307830929756,
-0.013135339133441448,
0.03248776122927666,
0.03524571284651756,
0.022612882778048515,
0.0018741815583780408,
0.020930064842104912,
-0.0031611293088644743,
-0.013357377611100674,
0.017868267372250557,
0.03353952243924141,
-0.014327336102724075,
0.007742137182503939,
-0.0022422983311116695,
-0.024447623640298843,
0.01622050814330578,
-0.04387016221880913,
0.011125304736196995,
0.01899014785885811,
0.012399105355143547,
-0.014876589179039001,
0.01950434222817421,
-0.025429269298911095,
0.017728032544255257,
-0.0047913603484630585,
-0.013111966662108898,
0.010476718656718731,
-0.018686305731534958,
0.004411557223647833,
0.020871633663773537,
0.03237089887261391,
0.003435756079852581,
0.02823396772146225,
0.014303963631391525,
-0.0019705931190401316,
-0.0056327697820961475,
-0.025359151884913445,
-0.01168624497950077,
0.013766396790742874,
-0.030898431316018105,
0.016723016276955605,
0.036858417093753815,
0.01140577532351017,
-0.0036081280559301376,
0.0013950454303994775,
0.04632427543401718,
0.0002547236217651516,
0.012025145813822746,
-0.03435755893588066,
0.021327396854758263,
-0.021350769326090813,
-0.008379037491977215,
0.09433136880397797,
-0.03861135244369507,
-0.009477544575929642,
0.005448711570352316,
-0.01154601015150547,
-0.0034532854333519936,
0.030430981889367104,
-0.01903689280152321,
0.011259696446359158,
-0.02229735441505909,
0.01624388061463833,
0.00012115349090890959,
0.03952287882566452,
0.030921803787350655,
0.024517741054296494,
-0.007502569351345301,
0.007268844172358513,
0.03377324715256691,
-0.007765509653836489,
-0.0037512846756726503,
0.010032640770077705,
0.003765892470255494,
-0.01657109521329403,
0.0570288747549057,
-0.03316556289792061,
0.006462493445724249,
-0.002620640443637967,
-0.03239427134394646,
0.03531583026051521,
-0.02285829558968544,
-0.0012599232140928507,
0.012551027350127697,
0.030898431316018105,
-0.03858797997236252,
0.007736294064670801,
-0.023769821971654892,
0.0007146869320422411,
-0.031576234847307205,
-0.0019925048109143972,
0.04576333612203598,
0.026995224878191948,
0.020006850361824036,
-0.026177188381552696,
0.05118575319647789,
0.0038243236485868692,
0.03961636871099472,
-0.03260462358593941,
-0.0014702756889164448,
0.02874816209077835,
-0.013883259147405624,
0.015542705543339252,
0.004358969163149595,
0.002604571869596839,
-0.0018069855868816376,
-0.01659446768462658,
-0.02311539277434349,
0.029449336230754852,
-0.008864016272127628,
-0.01369627844542265,
-0.007730450946837664,
0.0272990670055151,
0.048474542796611786,
-0.026410913094878197,
-0.024354133754968643,
0.014724668115377426
] | 2024-07-09 | 1 | 38980259 | [
"cancer treatment",
"clinical outcomes",
"Various STING agonists",
"clinical approval",
"clinical successes",
"non-nucleotide agonists",
"novel anticancer therapeutics",
"various cancers",
"cancer patients",
"anticancer therapeutics",
"pro-inflammatory cytokines",
"immune checkpoint therapy",
"new therapeutic molecules",
"cancer",
"STING",
"chimeric antigen receptor",
"systemic treatment",
"intratumoral administration",
"Therapeutic interventions",
"adaptive immunity",
"transcriptional cascades",
"T cells",
"substantial efforts",
"interferon genes",
"most CDNs",
"STING-activating therapeutics",
"the innate immune system",
"type",
"CAR",
"natural or synthetic cyclic dinucleotides"
] | [
"Cancer",
"Immune checkpoint blockade",
"Immunotherapy",
"STING",
"Small-molecule agonist"
] | 0 | 10.1002/cbic.202400255 | [
"Huang",
"Tong",
"Ren",
"Wang"
] | [
"Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.",
"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.",
"The First Affiliated Hospital, NHC Key Laboratory of Combined Multi-Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Zhejiang Province, Hangzhou, 310003, P. R. China.",
"The First Affiliated Hospital, NHC Key Laboratory of Combined Multi-Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Zhejiang Province, Hangzhou, 310003, P. R. China.\nJinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong Province, 250117, P. R. China."
] | [
"38980259"
] | [] | 10.775232 | 4.372947 |
38979201 | 749 | Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells. | Adoptive chimeric antigen receptor T-cell (CAR-T) therapy is transformative and approved for hematologic malignancies. It is also being developed for the treatment of solid tumors, autoimmune disorders, heart disease, and aging. Despite unprecedented clinical outcomes, CAR-T and other engineered cell therapies face a variety of manufacturing and safety challenges. Traditional methods, such as lentivirus transduction and electroporation, result in random integration or cause significant cellular damage, which can limit the safety and efficacy of engineered cell therapies. We present hydroporation as a gentle and effective alternative for intracellular delivery. Hydroporation resulted in 1.7- to 2-fold higher CAR-T yields compared to electroporation with superior cell viability and recovery. Hydroporated cells exhibited rapid proliferation, robust target cell lysis, and increased pro-inflammatory and regulatory cytokine secretion in addition to improved CAR-T yield by day 5 post-transfection. We demonstrate that scaled-up hydroporation can process 5 x 10 | [
0.02627796120941639,
0.0044775125570595264,
0.04219800606369972,
0.0667949691414833,
-0.008837602101266384,
-0.035622335970401764,
-0.02692069672048092,
0.012125437147915363,
0.016562778502702713,
-0.013670473359525204,
0.009671921841800213,
0.0211484432220459,
-0.04855119064450264,
-0.004653646610677242,
-0.003606112441048026,
-0.050677161663770676,
0.04031924158334732,
-0.006458248011767864,
0.005546676926314831,
0.009962388314306736,
0.010487699881196022,
0.018676387146115303,
-0.003847138024866581,
0.0014299302129074931,
-0.04106086120009422,
-0.010697824880480766,
0.0027872438076883554,
0.019504526630043983,
-0.021420370787382126,
-0.05107269063591957,
0.025165535509586334,
-0.02329913340508938,
-0.011804070323705673,
-0.03609202802181244,
0.03223561868071556,
0.059972092509269714,
0.041135020554065704,
0.01570991985499859,
-0.025054292753338814,
-0.023509258404374123,
0.046796031296253204,
0.005104796960949898,
0.015190787613391876,
0.06555894017219543,
-0.040640611201524734,
0.012632208876311779,
-0.031024310737848282,
-0.04553528130054474,
0.022372111678123474,
0.013769355602562428,
-0.015561596490442753,
-0.004146874882280827,
-0.029837723821401596,
-0.004047992639243603,
-0.04726572334766388,
0.006365545559674501,
-0.025659946724772453,
0.02019670233130455,
-0.03675948083400726,
0.02053043060004711,
-0.0017721555195748806,
-0.0132131427526474,
0.020357385277748108,
-0.03900905326008797,
-0.039923712611198425,
0.023237332701683044,
-0.06887149810791016,
-0.02295304462313652,
0.008497694507241249,
0.041431669145822525,
-0.0035381310153752565,
-0.03937986120581627,
0.01085232850164175,
-0.01857750490307808,
0.011655746959149837,
-0.010153972543776035,
-0.02506665326654911,
0.03151872009038925,
0.02612963877618313,
-0.008367911912500858,
0.04091253504157066,
-0.05077604204416275,
0.014597494155168533,
-0.04009675607085228,
-0.043656520545482635,
-0.012218140065670013,
0.004619655665010214,
-0.038638245314359665,
-0.03893489018082619,
0.0004480602510739118,
-0.024794727563858032,
0.03488072007894516,
-0.011482702568173409,
0.016365014016628265,
-0.03537512943148613,
0.03458407148718834,
0.005055355839431286,
-0.04031924158334732,
0.028898341581225395,
0.040146198123693466,
0.06921758502721786,
0.003083890536800027,
-0.026253240182995796,
-0.0002962605212815106,
0.04808150231838226,
-0.006445887498557568,
-0.04284074157476425,
-0.022780001163482666,
0.04790845513343811,
0.0006759529933333397,
0.06031817942857742,
-0.044645342975854874,
-0.03114791214466095,
0.07678207755088806,
-0.01642681658267975,
-0.04333515092730522,
0.0060534486547112465,
-0.0009911401430144906,
-0.023459816351532936,
0.025684667751193047,
-0.03683364391326904,
-0.002108973218128085,
0.05156709998846054,
0.0002502957358956337,
-0.0036648239474743605,
0.0020085459109395742,
0.0634329691529274,
-0.019541608169674873,
-0.022928325459361076,
-0.046227458864450455,
0.026376843452453613,
0.04026980325579643,
0.010592762380838394,
-0.03826743736863136,
-0.034064941108226776,
0.00114718871191144,
-0.02714318223297596,
0.038712404668331146,
-0.003185862908139825,
-0.004261207766830921,
0.016859425231814384,
-0.03673475980758667,
-0.011958573944866657,
-0.0028598604258149862,
-0.04069005325436592,
-0.047364603728055954,
0.017057189717888832,
0.04691963270306587,
-0.010586582124233246,
0.06387794017791748,
-0.016241412609815598,
0.038217995315790176,
0.027242064476013184,
0.02627796120941639,
0.01630321331322193,
-0.05443468689918518,
-0.004221036564558744,
0.06580614298582077,
-0.03782246634364128,
-0.05408859997987747,
-0.02499249204993248,
0.001637737499549985,
-0.03206257522106171,
-0.057005625218153,
-0.01085232850164175,
-0.03080182522535324,
0.010123071260750294,
0.018132535740733147,
-0.08029239624738693,
-0.030208531767129898,
-0.047166839241981506,
-0.035127922892570496,
-0.034485191106796265,
-0.01582116261124611,
-0.04385428503155708,
0.0046721869148314,
-0.00794766191393137,
0.02484416961669922,
-0.02295304462313652,
-0.01638973504304886,
0.031024310737848282,
0.04632633924484253,
0.01457277312874794,
-0.03389189764857292,
-0.006890857592225075,
-0.005015184637159109,
-0.03015908971428871,
0.03235922008752823,
-0.022940685972571373,
-0.00928875245153904,
-0.010704005137085915,
-0.01850334368646145,
0.049243368208408356,
-0.01236646343022585,
0.009134248830378056,
-0.01638973504304886,
0.040418125689029694,
0.009140429086983204,
0.007422349881380796,
-0.047883737832307816,
0.043087948113679886,
-0.009727542288601398,
-0.01690886728465557,
0.0021290588192641735,
-0.034188542515039444,
-0.035127922892570496,
-0.044645342975854874,
0.028181444853544235,
-0.006748714484274387,
0.013435627333819866,
0.02280472218990326,
0.010104531422257423,
-0.038860730826854706,
0.0468207523226738,
-0.027909519150853157,
-0.02420143410563469,
-0.008948844857513905,
0.0641745924949646,
0.020184341818094254,
0.035053763538599014,
-0.07154131680727005,
0.0017335297306999564,
-0.01977645233273506,
0.021494532003998756,
-0.03374357149004936,
0.0008860777597874403,
-0.0019915506709367037,
-0.048600632697343826,
0.027242064476013184,
-0.03149399906396866,
0.003377447370439768,
0.0024705114774405956,
0.010394997894763947,
-0.04073949158191681,
-0.03453462943434715,
-0.034114379435777664,
0.05028163269162178,
0.005744441412389278,
0.04911976307630539,
-0.021506892517209053,
-0.006489148363471031,
-0.0006666827830486,
0.007793158292770386,
-0.051023248583078384,
-0.0008366366382688284,
-0.00028660407406277955,
-0.024757646024227142,
-0.061405885964632034,
0.03260642662644386,
-0.015734640881419182,
-0.0068290564231574535,
-0.03725389391183853,
0.002679091412574053,
0.00515423808246851,
0.0494411326944828,
0.0036617338191717863,
0.02261931821703911,
-0.05799444764852524,
0.005027545150369406,
-0.026673490181565285,
-0.007793158292770386,
-0.009369094856083393,
-0.038860730826854706,
-0.019912416115403175,
-0.021951861679553986,
0.02778591588139534,
-0.000016814330592751503,
0.017081910744309425,
0.0007006735540926456,
-0.008819062262773514,
0.047883737832307816,
0.00388421886600554,
0.03193897008895874,
-0.010518601164221764,
-0.05784612521529198,
0.006779615301638842,
0.006977379787713289,
0.025758828967809677,
-0.010401178151369095,
0.03174120560288429,
-0.006452067755162716,
0.0065200491808354855,
-0.010018009692430496,
-0.037550538778305054,
-0.010228133760392666,
-0.009585399180650711,
0.0026497356593608856,
0.008905583992600441,
0.027736475691199303,
-0.04103614017367363,
0.0000036151413951301947,
-0.016278492286801338,
-0.018589865416288376,
-0.01017251331359148,
0.006445887498557568,
0.014201965183019638,
-0.002108973218128085,
0.012199599295854568,
-0.04677131026983261,
-0.02177881821990013,
-0.023360934108495712,
0.030480457469820976,
-0.0426676981151104,
-0.030455736443400383,
-0.00309625081717968,
0.028527533635497093,
-0.014881780371069908,
-0.012310842052102089,
0.027192622423171997,
0.017304396256804466,
0.009146609343588352,
0.007774617988616228,
0.025190256536006927,
0.022829443216323853,
-0.00020066146680619568,
0.024522801861166954,
0.013497428968548775,
-0.06175197288393974,
0.004270477686077356,
-0.06214750185608864,
-0.013744634576141834,
-0.017848247662186623,
-0.021717017516493797,
-0.00995002780109644,
0.04373067989945412,
-0.032556984573602676,
0.02495541051030159,
-0.025363299995660782,
0.02502957358956337,
-0.015957124531269073,
-0.020814716815948486,
-0.043013785034418106,
0.0392562597990036,
-0.04598025232553482,
0.004449701867997646,
-0.011235496960580349,
-0.012242860160768032,
-0.08049016445875168,
0.04553528130054474,
-0.025276778265833855,
-0.0156728383153677,
0.026624049991369247,
-0.0005581440054811537,
0.04202496260404587,
0.006319194566458464,
-0.03268058970570564,
0.0034732394851744175,
0.02449808083474636,
-0.007848779670894146,
0.024213794618844986,
-0.018886512145400047,
0.01883707195520401,
0.0062913838773965836,
0.028379209339618683,
0.002257296582683921,
0.05507742241024971,
-0.012978296726942062,
-0.01007981039583683,
-0.0062852040864527225,
-0.009857325814664364,
0.02427559532225132,
0.049515292048454285,
-0.045733045786619186,
0.027761194854974747,
0.04889727756381035,
0.040566448122262955,
-0.029096106067299843,
0.05131989344954491,
-0.045016150921583176,
-0.026747651398181915,
-0.0020162712316960096,
-0.013967120088636875,
0.026253240182995796,
0.037352774292230606,
-0.05005914717912674,
0.02499249204993248,
0.05567071586847305,
0.018973033875226974,
0.026228521019220352,
0.017168432474136353,
0.06007097661495209,
-0.014053641818463802,
-0.04892199859023094,
-0.009078627452254295,
-0.02778591588139534,
0.023459816351532936,
0.029491635039448738,
0.0063161044381558895,
-0.05695618316531181,
0.02620379999279976,
0.022780001163482666,
-0.01865166611969471,
0.0035844820085912943,
-0.026673490181565285,
-0.018206696957349777,
0.09037838876247406,
-0.032631147652864456,
0.04800733923912048,
0.031543441116809845,
0.0015643483493477106,
0.015957124531269073,
0.0036740940995514393,
-0.04251937195658684,
-0.026080196723341942,
0.03621562942862511,
0.0009200685890391469,
0.03955290466547012,
0.02260695770382881,
0.006791975349187851,
-0.00048591362428851426,
-0.0008335465681739151,
-0.015882963314652443,
0.03950346261262894,
0.030480457469820976,
0.026376843452453613,
-0.015264949761331081,
-0.021123724058270454,
0.0220878254622221,
-0.026228521019220352,
0.026797093451023102,
0.013744634576141834,
-0.03826743736863136,
-0.0173661969602108,
-0.023645220324397087,
-0.0008358641061931849,
0.017081910744309425,
0.041135020554065704,
0.0032847451511770487,
-0.019998937845230103,
-0.012045095674693584,
-0.02140801027417183,
0.025511624291539192,
-0.005117157008498907,
-0.024584602564573288,
-0.012069816701114178,
0.04298906400799751,
-0.022940685972571373,
0.022112546488642693,
-0.03206257522106171,
0.019603408873081207,
-0.020246142521500587,
0.022186707705259323,
0.028947781771421432,
-0.02460932359099388,
0.0026868165004998446,
0.0013858966995030642,
-0.005645559169352055,
0.0190719161182642,
-0.07292567193508148,
-0.03787190839648247,
-0.03831687569618225,
0.014436810277402401,
-0.005052265711128712,
0.0017319846665486693,
-0.016402095556259155,
-0.005568307358771563,
0.014918861910700798,
-0.0743594616651535,
-0.0024195252917706966,
0.01786060817539692,
-0.0021306038834154606,
-0.02392950840294361,
0.027983680367469788,
-0.037204451858997345,
-0.01364575233310461,
0.06536117941141129,
0.04825454577803612,
-0.04212384298443794,
-0.01578408107161522,
-0.020023658871650696,
-0.002617290010675788,
-0.0005650966777466238,
-0.037426937371492386,
0.0247329268604517,
-0.019282041117548943,
0.0030282693915069103,
0.014016561210155487,
0.015302030369639397,
0.014177244156599045,
0.008108345791697502,
-0.015413273125886917,
-0.01986297406256199,
-0.03193897008895874,
-0.0051758685149252415,
0.016167249530553818,
0.05843941867351532,
-0.0034516090527176857,
-0.025054292753338814,
-0.03732805326581001,
-0.0005678004818037152,
0.02027086354792118,
-0.007403809577226639,
0.0362403504550457,
-0.012378823012113571,
-0.025017213076353073,
-0.001252251211553812,
-0.03836631774902344,
0.011216957122087479,
-0.0026852714363485575,
0.006087439134716988,
0.01296593714505434,
0.017489800229668617,
-0.0016083818627521396,
-0.00293093197979033,
0.04771069064736366,
0.028255606070160866,
0.03159288316965103,
0.050380513072013855,
0.00469999760389328,
0.007848779670894146,
-0.029318591579794884,
0.0020873427856713533,
0.04160471260547638,
-0.01553687546402216,
-0.053099773824214935,
-0.02401603013277054,
-0.030752383172512054,
0.01578408107161522,
-0.021679935976862907,
-0.0023051928728818893,
-0.0339660570025444,
-0.01959104835987091,
-0.0362403504550457,
0.0173661969602108,
0.01457277312874794,
-0.03839103877544403,
-0.035696495324373245,
-0.006025637965649366,
-0.027612872421741486,
-0.01017251331359148,
0.03268058970570564,
0.01887415163218975,
-0.009820245206356049,
0.013262583874166012,
-0.02936803176999092,
-0.015277309343218803,
-0.02205074392259121,
0.025079013779759407,
-0.025832992047071457,
-0.023039568215608597,
-0.004931753035634756,
0.0002856384089682251,
0.01786060817539692,
-0.012891774997115135,
-0.0024334306363016367,
0.007879680022597313,
0.011006832122802734,
-0.031123192980885506,
0.033199720084667206,
-0.017007749527692795,
0.03715500980615616,
-0.017576321959495544,
0.02771175466477871,
0.008262849412858486,
0.03470767289400101,
-0.02397894859313965,
-0.0063346452079713345,
-0.014103082939982414,
-0.010623662732541561,
-0.01596948504447937,
0.0021877700928598642,
0.006143060512840748,
0.024831809103488922,
-0.026401564478874207,
-0.030529899522662163,
0.05492909625172615,
0.004177775699645281,
-0.02057987079024315,
-0.044150929898023605,
0.024621684104204178,
-0.023200251162052155,
-0.02015962079167366,
0.021086642518639565,
-0.03621562942862511,
0.0494658537209034,
0.0046381959691643715,
-0.003995461389422417,
-0.0005697318119928241,
-0.00023851484002079815,
0.0033959876745939255,
-0.013188421726226807,
-0.020604591816663742,
-0.017156071960926056,
0.028329769149422646,
-0.011408541351556778,
0.029170267283916473,
-0.03364469110965729,
0.01285469438880682,
-0.015475073829293251,
0.015116626396775246,
0.03703140839934349,
0.032631147652864456,
0.0351032018661499,
0.007749897427856922,
-0.04452173784375191,
0.0186887476593256,
0.030554618686437607,
-0.008108345791697502,
-0.02525205723941326,
-0.026945415884256363,
-0.025017213076353073,
-0.0030931606888771057,
0.014041281305253506,
-0.06214750185608864,
-0.018392100930213928,
0.029244428500533104,
0.007799338549375534,
-0.026624049991369247,
0.011581584811210632,
-0.020604591816663742,
0.03604258596897125,
0.005602298304438591,
-0.012230499647557735,
0.015104265883564949,
0.03144456073641777,
0.025808271020650864,
-0.003995461389422417,
0.009461796842515469,
0.01940564438700676,
-0.021049560979008675,
-0.03989899158477783,
0.010673103854060173,
-0.017922410741448402,
-0.007539772428572178,
-0.0053118313662707806,
-0.018219057470560074,
-0.006532409694045782,
0.012817613780498505,
-0.00860893726348877,
0.019727012142539024,
0.0028258697129786015,
-0.026821814477443695,
-0.02306428737938404,
0.03216145560145378,
-0.010833787731826305,
-0.0050028245896101,
-0.000005181300366530195,
-0.02095067873597145,
0.004449701867997646,
-0.003185862908139825,
-0.026104917749762535,
0.012527146376669407,
0.013188421726226807,
-0.015957124531269073,
0.008775800466537476,
0.0009030731744132936,
-0.038341596722602844,
-0.02057987079024315,
0.03893489018082619,
-0.01432556752115488,
0.012292301282286644,
-0.029343312606215477,
0.01725495420396328,
-0.02612963877618313,
-0.004625835921615362,
-0.007187504321336746,
0.017539242282509804,
-0.005148057825863361,
0.04212384298443794,
0.06808044016361237,
-0.015413273125886917,
0.014350288547575474,
0.01823141798377037,
-0.019343843683600426,
0.016711102798581123,
-0.0046721869148314,
0.018676387146115303,
-0.009709002450108528,
-0.005141877569258213,
0.01381879672408104,
0.07668319344520569,
0.025585785508155823,
-0.010827607475221157,
-0.03008492849767208,
-0.010048910044133663,
-0.013979479670524597,
0.005472515244036913,
-0.035696495324373245,
-0.016179610043764114,
0.021605774760246277,
-0.03008492849767208,
0.02102484181523323,
-0.05695618316531181,
-0.036635879427194595,
0.027316225692629814,
-0.0054385242983698845,
0.029343312606215477,
0.014350288547575474,
-0.00789204053580761,
0.013472707942128181,
-0.007922941818833351,
-0.022780001163482666,
-0.022285589948296547,
-0.003927479963749647,
0.026970136910676956,
0.008145426400005817,
0.008917944505810738,
-0.006489148363471031,
-0.0011054727947339416,
-0.013237862847745419,
0.015475073829293251,
0.017601042985916138,
0.026253240182995796,
-0.02148217149078846,
0.023694662377238274,
-0.011260217987000942,
-0.0058989450335502625,
-0.021383289247751236,
0.000475870881928131,
0.01710663177073002,
0.023398015648126602,
0.004344639368355274,
-0.008065084926784039,
-0.023731743916869164,
0.012428264133632183,
0.005963836330920458,
0.02835448831319809,
0.031617604196071625,
0.024263234809041023,
0.030826546251773834,
0.0077128163538873196,
-0.008343190886080265,
-0.02488124929368496,
0.012706371024250984,
-0.0021537793800234795,
0.025165535509586334,
-0.027242064476013184,
0.062196943908929825,
-0.006890857592225075,
-0.011074813082814217,
0.01687178574502468,
-0.02650044672191143,
-0.03757525980472565,
-0.020110180601477623,
-0.02793424017727375,
0.025338580831885338,
-0.034485191106796265,
-0.02212490700185299,
-0.0062079522758722305,
-0.009196050465106964,
0.017601042985916138,
0.011037732474505901,
0.009634840302169323,
0.022470993921160698,
0.006260483525693417,
0.017489800229668617,
0.039775390177965164,
0.004443521611392498,
0.0024844168219715357,
-0.04269241541624069,
0.000054365933465305716,
0.00923313107341528,
-0.017193153500556946,
0.017638124525547028,
0.0015349925961345434,
-0.043928444385528564,
0.019380923360586166,
-0.0029664679896086454,
-0.02121024578809738,
-0.03015908971428871,
-0.008615117520093918,
0.008658378385007381,
-0.014473890885710716,
0.0022140357177704573,
0.0017582502914592624,
-0.011074813082814217,
0.017452718690037727,
0.014795258641242981,
-0.019850613549351692,
0.020443908870220184,
-0.023249691352248192,
0.008262849412858486,
0.005732081364840269,
0.00004043647277285345,
-0.008021824061870575,
-0.009171330370008945,
-0.011414721608161926,
0.0313456766307354,
-0.02442391961812973,
0.005759892053902149,
-0.034485191106796265,
0.0190595556050539,
-0.021655214950442314,
0.022718200460076332,
-0.012694010511040688,
-0.008781980723142624,
0.010166333056986332,
0.01650097779929638,
-0.013151341117918491,
-0.01966520957648754,
-0.009406175464391708,
0.02793424017727375,
-0.013336745090782642,
0.03747637942433357,
0.000479347218060866,
0.024893609806895256,
0.05077604204416275,
-0.07861139625310898,
-0.0054076239466667175,
-0.0024720565415918827,
-0.03631450980901718,
0.0317164845764637,
0.009573038667440414,
-0.04825454577803612,
0.005963836330920458,
0.014733457006514072,
-0.018441542983055115,
0.027093740180134773,
-0.04118446260690689,
0.018515704199671745,
0.007533592637628317,
0.00018839775293599814,
-0.015623397193849087,
0.014016561210155487,
-0.07950133830308914,
0.009467977099120617,
0.03099958971142769,
-0.019158437848091125,
-0.014918861910700798,
-0.0017288945382460952,
0.04778485372662544,
-0.02506665326654911,
0.012218140065670013,
-0.0005210631643421948,
-0.013855877332389355,
-0.03295251354575157,
-0.013089539483189583,
0.005834053736180067,
0.009140429086983204,
-0.028601694852113724,
0.0050028245896101,
-0.0077375369146466255,
-0.04798261821269989,
0.03507848456501961,
-0.007780798245221376,
-0.0203821063041687,
-0.009523597545921803,
-0.003201313316822052,
0.0021367839071899652,
0.01959104835987091,
0.014646935276687145,
-0.029986046254634857,
-0.005148057825863361,
-0.024584602564573288,
0.005055355839431286,
0.02389242686331272,
-0.005908215418457985,
0.013151341117918491,
-0.029911885038018227,
-0.014276126399636269,
-0.002193950116634369,
-0.000040122638893080875,
-0.013596311211585999,
-0.013732274062931538,
0.018515704199671745,
0.006810516119003296,
0.006452067755162716,
-0.018107814714312553,
0.04882311820983887,
0.034114379435777664,
-0.037624701857566833,
-0.003927479963749647,
-0.015845883637666702,
-0.041926078498363495,
0.043211549520492554,
-0.043211549520492554,
0.028750017285346985,
-0.004789609462022781,
0.01570991985499859,
-0.01841682195663452,
0.02102484181523323,
-0.005327282007783651,
-0.01611780934035778,
-0.015685198828577995,
0.007224585395306349,
0.01032701600342989,
0.004724718164652586,
-0.0003408734337426722,
-0.01296593714505434,
-0.02808256261050701,
0.021457450464367867,
-0.0437801219522953,
0.016142530366778374,
-0.020666392520070076,
0.0015751635655760765,
0.011736088432371616,
-0.018181975930929184,
-0.019282041117548943,
-0.011297298595309258,
-0.001460058381780982,
-0.017502160742878914,
-0.02914554625749588,
-0.0241643525660038,
-0.031246794387698174,
-0.013089539483189583,
0.016167249530553818,
-0.020592231303453445,
0.02692069672048092,
-0.03349636495113373,
-0.011797890067100525,
-0.03582010045647621,
-0.03819327428936958,
-0.01414016354829073,
0.04467006400227547,
-0.015190787613391876,
0.012477705255150795,
-0.00836173165589571,
0.02313845045864582,
-0.009517418220639229,
0.031543441116809845,
-0.01002418901771307,
0.01202655490487814,
0.003976921085268259,
0.03745165839791298,
0.0013264128938317299,
0.018441542983055115,
-0.02612963877618313,
0.08370383828878403,
0.00830611027777195,
-0.011736088432371616,
-0.0354987308382988,
-0.02231031097471714,
0.005923665594309568,
-0.01485706027597189,
0.031197354197502136,
0.004177775699645281,
0.0014237500727176666,
0.0035504912957549095,
0.00006334645149763674,
-0.007119522895663977,
0.02793424017727375,
-0.004625835921615362,
0.0509738065302372,
0.025956593453884125,
0.030925428494811058,
-0.015833523124456406,
0.02189006097614765,
0.004122154321521521,
-0.013312024995684624,
0.008757260628044605,
-0.031049029901623726,
0.02434975653886795,
0.002082707593217492,
-0.026871254667639732,
0.030060207471251488,
-0.026179078966379166,
0.003479419741779566,
-0.03824271634221077,
0.03080182522535324,
0.008707819506525993,
0.0664488822221756,
-0.0095359580591321,
0.026895975694060326,
0.01615488901734352,
-0.005812422838062048,
-0.036339230835437775,
0.019912416115403175,
-0.01718079298734665,
0.07277734577655792,
-0.024139633402228355,
-0.01468401588499546,
0.018392100930213928,
-0.006377906072884798,
-0.017341477796435356,
0.016525698825716972,
0.04088781774044037,
-0.006201772019267082,
0.009084807708859444,
-0.04276657849550247,
0.004542403854429722,
-0.023472176864743233,
-0.017724646255373955,
-0.011235496960580349,
0.03957762569189072,
0.02543746307492256,
0.00909716822206974,
0.013237862847745419,
-0.026945415884256363,
0.026673490181565285,
0.030109649524092674,
0.018973033875226974,
0.022718200460076332,
-0.025684667751193047,
-0.01517842710018158,
-0.022545157000422478,
0.013040098361670971,
0.007447070442140102,
-0.03717973083257675,
-0.0028923063073307276,
0.001613016938790679,
0.05364362895488739,
0.03087598644196987,
-0.016513338312506676,
-0.03166704624891281,
-0.0036864543799310923,
-0.03374357149004936,
-0.028947781771421432,
-0.019430365413427353,
0.04130806401371956,
0.04835342615842819,
-0.018973033875226974,
-0.0033867175225168467,
0.051023248583078384,
-0.012780532240867615,
-0.014943582005798817,
0.007107162848114967,
0.054533567279577255,
0.013225502334535122,
0.06783322989940643,
-0.024510441347956657,
0.06704217195510864,
0.02423851564526558,
0.012978296726942062,
-0.014066002331674099,
0.009183689951896667,
-0.03772358223795891,
-0.013658112846314907,
-0.0509738065302372,
-0.021803539246320724,
0.010351737029850483,
-0.002730077598243952,
-0.017044831067323685,
0.007471791002899408,
0.027983680367469788,
0.02057987079024315,
-0.014276126399636269,
0.017044831067323685,
-0.024671124294400215,
-0.021469810977578163,
0.020394466817378998,
0.029615238308906555,
-0.003813147312030196,
-0.006322284694761038,
-0.021395649760961533,
-0.04521391540765762,
0.026080196723341942,
-0.016859425231814384,
0.048674795776605606,
0.023422736674547195,
0.03228506073355675,
-0.023880066350102425,
-0.021234966814517975,
0.010784346610307693,
0.044002607464790344,
-0.03646283596754074,
0.011637206189334393,
-0.009140429086983204,
-0.03668532148003578,
0.005800062790513039,
0.028057841584086418,
0.023311493918299675,
0.039280980825424194,
0.023954227566719055,
-0.001497139222919941,
0.02605547569692135,
0.015302030369639397,
0.005843323655426502,
-0.001625377219170332,
0.009325833059847355,
0.013003017753362656,
-0.009610120207071304,
0.05112212896347046,
-0.015252589248120785,
0.017230235040187836,
-0.01389295794069767,
0.006965019274502993,
0.04140694811940193,
0.02650044672191143,
0.016439177095890045,
-0.001688723685219884,
0.01721787452697754,
-0.007261666003614664,
-0.004310648888349533,
0.0062326728366315365,
0.0313456766307354,
-0.02556106448173523,
0.0029525626450777054,
-0.008973564952611923,
0.011315839365124702,
-0.050726599991321564,
0.026747651398181915,
0.02352161891758442,
0.001588296378031373,
-0.023620501160621643,
-0.014399729669094086,
-0.0035659417044371367,
-0.005525046493858099,
0.001236800802871585,
0.014461531303822994,
-0.025585785508155823,
-0.02453516237437725,
-0.04318682849407196,
-0.004100523889064789,
0.0020857977215200663,
0.007793158292770386,
-0.003405258059501648,
0.010407358407974243,
0.018960673362016678,
0.04850174859166145,
0.01646389625966549,
-0.017168432474136353,
0.020209062844514847,
-0.0072431256994605064,
-0.032828912138938904,
-0.05087492614984512,
0.05784612521529198,
-0.010153972543776035,
-0.04182719811797142,
0.022137267515063286,
0.002997368574142456,
-0.0014376554172486067,
0.0028351398650556803,
0.024547521024942398,
-0.006146150641143322,
0.005364362616091967,
0.018923593685030937,
0.02212490700185299,
-0.029590517282485962,
0.005398353561758995,
0.011729908175766468,
-0.011445621959865093,
-0.030060207471251488,
-0.021074282005429268,
-0.005262390244752169,
0.007354368455708027,
0.0013920768396928906,
-0.005367452744394541,
0.0275634303689003,
0.0034577890764921904,
0.015104265883564949,
-0.008924123831093311,
0.014745817519724369,
0.012829973362386227,
-0.003834777744486928,
-0.022137267515063286,
-0.000001370011773360602,
-0.0046721869148314,
-0.013583950698375702,
0.0014886416029185057,
0.005114066880196333,
0.04612857475876808,
0.01364575233310461,
-0.008837602101266384,
-0.038564082235097885,
-0.0066745528019964695,
-0.01634029485285282,
-0.002910846611484885,
0.04857591167092323,
-0.021111363545060158,
-0.061554208397865295,
0.030208531767129898,
-0.010951210744678974,
-0.020740555599331856,
-0.00923313107341528,
-0.005815512966364622,
-0.008831421844661236,
-0.02337329462170601,
-0.004641286097466946,
0.02729150466620922,
0.0247329268604517,
0.0011981748975813389,
0.011593945324420929,
0.013126620091497898,
-0.015030103735625744,
-0.003899669274687767,
-0.027167901396751404,
-0.0019328392809256911,
0.02899722382426262,
0.028478091582655907,
-0.004344639368355274,
-0.0009015281102620065,
-0.01317606121301651,
0.020715834572911263,
0.037847187370061874,
0.04091253504157066,
0.026970136910676956,
0.0388854518532753,
-0.0014052096521481872,
-0.01153214368969202,
-0.00746561074629426,
-0.01553687546402216,
0.019034836441278458,
0.00022712019563186914,
-0.028774738311767578,
-0.04684547334909439,
-0.008497694507241249,
-0.011124254204332829,
-0.007261666003614664,
-0.013386186212301254,
-0.01090794987976551,
-0.013324384577572346,
-0.03337276354432106,
0.003989281132817268,
-0.006294474005699158,
-0.01638973504304886,
-0.0075768535025417805,
-0.01593240536749363,
-0.008590396493673325,
0.0007365955971181393,
0.010302295908331871,
-0.022297950461506844,
0.03643811494112015,
0.030900707468390465,
-0.0019096636679023504,
0.0203821063041687,
0.030554618686437607,
-0.01158776506781578,
-0.013188421726226807,
0.00508625665679574,
-0.04476894438266754,
0.013040098361670971,
-0.04523863643407822,
-0.0012800617842003703,
0.0123602831736207,
-0.010160152800381184,
-0.03122207522392273,
0.0049193925224244595,
0.01145798247307539,
0.014127803035080433,
0.008188687264919281,
-0.008238128386437893,
-0.01238500326871872,
0.015833523124456406,
0.007749897427856922,
0.004032542463392019,
-0.04382956400513649,
0.023793544620275497,
-0.0013434082502499223,
-0.001599111594259739,
0.018478622660040855,
-0.0156728383153677,
-0.033125557005405426,
0.015128985978662968,
0.013003017753362656,
0.006686912849545479,
-0.0025477632880210876,
0.0018185066292062402,
0.01706955023109913,
-0.020258503034710884,
0.04182719811797142,
0.00624812301248312,
0.013756995089352131,
-0.0037297154776751995,
-0.02748926915228367,
-0.006594210863113403,
0.009140429086983204,
0.03582010045647621,
0.005287110805511475,
0.026030756533145905,
-0.006921758409589529,
-0.008979745209217072,
-0.024671124294400215,
-0.024485720321536064,
-0.03302667662501335,
-0.008837602101266384,
0.013386186212301254,
0.022211428731679916,
-0.02087651751935482,
-0.01850334368646145,
0.010388817638158798,
0.053742509335279465,
0.008021824061870575,
0.0021275137551128864,
-0.004026362206786871,
-0.022149626165628433,
-0.009369094856083393,
-0.0196281298995018,
-0.0006686140550300479,
0.0419013574719429,
0.025227338075637817,
0.0035195904783904552,
0.035350408405065536,
-0.012125437147915363,
0.05334698036313057,
-0.011204596608877182,
0.019269680604338646,
-0.019158437848091125,
0.007082442287355661,
-0.003352726809680462,
0.008028003387153149,
-0.01729203574359417,
0.00635936576873064,
0.02857697382569313,
-0.013794075697660446,
-0.04051700606942177,
0.04026980325579643,
-0.0118905920535326,
-0.005883494857698679,
-0.02672293223440647,
-0.007564492989331484,
0.01959104835987091,
0.0019591047894209623,
0.00025068200193345547,
0.00843589287251234,
-0.0015543055487796664,
-0.008763440884649754,
-0.010870869271457195,
-0.003544311039149761,
0.0152896698564291,
-0.0019652850460261106,
-0.02929387055337429,
0.004978104028850794,
0.008615117520093918,
-0.04625217989087105,
-0.07070081681013107,
0.028947781771421432,
0.005963836330920458,
-0.020147260278463364,
0.005812422838062048,
-0.004146874882280827,
0.016179610043764114,
0.03181536868214607,
-0.06180141493678093,
0.003365087090060115,
0.019529247656464577,
0.028898341581225395,
-0.011315839365124702,
-0.005722810979932547,
0.006866137031465769,
0.01093266997486353,
0.00807744450867176,
0.011025371961295605,
-0.027835357934236526,
0.010710185393691063,
0.030134370550513268,
-0.031840089708566666,
0.004594935104250908,
0.031197354197502136,
0.0032353040296584368,
-0.009035366587340832,
0.004730898421257734,
-0.01183497067540884,
0.05270424485206604,
-0.015660477802157402,
-0.01085232850164175,
-0.012792892754077911,
-0.0026250150986015797,
-0.0017845157999545336,
-0.0017829708522185683,
0.013312024995684624,
0.0106669245287776,
0.01255186740309,
0.005265480373054743,
0.024943051859736443,
-0.01815725490450859,
-0.0023051928728818893,
0.01978881284594536,
0.017947129905223846,
-0.0060287280939519405,
-0.00635936576873064,
0.008343190886080265,
-0.015128985978662968,
-0.024337397888302803,
0.012174878269433975,
-0.012941216118633747,
-0.0025987494736909866,
0.009764623828232288,
0.016513338312506676,
-0.018812350928783417,
0.0008883953560143709,
0.0006709315930493176,
0.027093740180134773,
-0.011847331188619137,
-0.009789343923330307,
-0.011278757825493813,
0.0005025227437727153,
-0.008584216237068176,
-0.02820616587996483,
-0.009770804084837437,
-0.014869420789182186,
0.012477705255150795,
-0.022001303732395172,
0.033990778028964996,
-0.0019915506709367037,
0.010153972543776035,
0.021506892517209053,
0.020925959572196007,
-0.004338459111750126,
-0.004891581833362579,
-0.022396832704544067,
0.035770658403635025,
-0.05275368690490723,
-0.038415759801864624,
-0.04145639017224312,
-0.012100717052817345,
-0.00951123796403408,
-0.005419983994215727,
-0.03493015840649605,
0.0007678825641050935,
0.004866861272603273,
0.008065084926784039,
0.007434710394591093,
0.007076262030750513,
0.0031194263137876987,
0.006569490302354097,
-0.01664930023252964,
0.015796441584825516,
-0.0007157376385293901,
0.0456836074590683,
-0.011080993339419365,
-0.006575670558959246,
-0.008083624765276909,
-0.022470993921160698,
0.0028861260507255793,
-0.017687564715743065,
-0.04612857475876808,
0.012230499647557735,
0.014313207939267159,
0.009789343923330307,
-0.011470342986285686,
-0.012434444390237331,
-0.011445621959865093,
0.04738932475447655,
-0.04560944437980652,
-0.0030668952967971563,
0.007620114367455244,
0.017156071960926056,
0.03601786494255066,
0.03594370186328888,
-0.0036988146603107452,
0.011692827567458153,
-0.0070144603960216045,
0.01766284368932247,
-0.007861140184104443,
0.00642734719440341,
0.032903071492910385,
-0.031024310737848282,
-0.04835342615842819,
0.01887415163218975,
0.007811698596924543,
-0.029664678499102592,
0.007657195441424847,
-0.0027795187197625637,
0.0073976293206214905,
0.009109528735280037,
-0.0247205663472414,
0.01164956670254469,
0.0019112087320536375,
0.01812017522752285,
0.030455736443400383,
0.032977234572172165,
-0.03317499905824661,
0.01755160093307495,
-0.01096357125788927,
-0.015796441584825516,
-0.013138980604708195,
0.0006504599004983902,
-0.007280206773430109,
0.007496511563658714,
-0.005185138899832964,
0.015351471491158009,
0.029392752796411514,
0.006115249823778868,
-0.01238500326871872,
0.009060087613761425,
-0.029269149526953697,
-0.010704005137085915,
0.015091905370354652,
-0.020073099061846733,
-0.007898220792412758,
0.05497853830456734,
0.0007837191806174815,
0.021642856299877167,
0.016772903501987457,
-0.0010336287086829543,
-0.01782352849841118,
-0.0030545350164175034,
-0.01837974041700363,
0.006272843573242426,
-0.0156728383153677,
-0.0015628032851964235,
0.08068792521953583,
-0.029417473822832108,
-0.029590517282485962,
0.037624701857566833,
0.028403930366039276,
-0.026401564478874207,
0.02400366961956024,
0.01650097779929638,
0.009066267870366573,
-0.004258117638528347,
0.03307611867785454,
0.011538323946297169,
0.034064941108226776,
-0.008188687264919281,
0.03493015840649605,
-0.023360934108495712,
0.016179610043764114,
0.01846626214683056,
0.002365449210628867,
-0.025758828967809677,
-0.02502957358956337,
0.0070391809567809105,
0.0046567367389798164,
0.027340946719050407,
-0.02453516237437725,
-0.009987108409404755,
-0.006680733058601618,
0.0017968760803341866,
-0.0026605508755892515,
-0.010580401867628098,
0.027909519150853157,
-0.008429712615907192,
0.022928325459361076,
-0.000953286828007549,
-0.01496830303221941,
-0.05275368690490723,
-0.004913212265819311,
-0.0038533182814717293,
-0.0027547981590032578,
-0.018886512145400047,
-0.021692296490073204,
0.009962388314306736,
-0.001422977540642023,
0.007626294624060392,
0.02857697382569313,
0.007298747077584267,
-0.03910793364048004,
0.0011881322134286165,
-0.00758921355009079,
-0.052951451390981674,
0.0004160007811151445,
-0.023187890648841858,
0.01936856284737587,
-0.015141346491873264,
-0.04452173784375191,
-0.0010197233641520143,
-0.0004333824326749891,
0.007854959927499294,
-0.015227868221700191,
-0.018070733174681664,
0.008707819506525993,
0.011519784107804298,
0.010401178151369095,
0.008534775115549564,
0.006143060512840748
] | 2024-07-09 | 63 | 38979201 | [
"engineered cell therapies",
"other engineered cell therapies",
"superior cell viability",
"Hydroporated cells",
"autoimmune disorders",
"significant cellular damage",
"solid tumors",
"improved CAR-T yield",
"lentivirus transduction",
"electroporation",
"heart disease",
"random integration",
"hydroporation",
"rapid proliferation",
"unprecedented clinical outcomes",
"intracellular delivery",
"-inflammatory and regulatory cytokine secretion",
"Adoptive chimeric antigen receptor T-cell (CAR-T) therapy",
"Traditional methods",
"CAR-T",
"hematologic malignancies",
"day",
"addition",
"efficacy",
"to 2-fold higher CAR-T yields",
"-",
"manufacturing and safety challenges",
"aging",
"2-fold",
"transfection"
] | [
"AAV",
"CAR-T",
"CRISPR",
"Cell Therapy",
"Cytokine",
"Gene editing",
"Intracellular delivery",
"Microfluidics",
"Serial killing",
"Vortex shedding"
] | 0 | 10.1101/2024.06.25.600671
10.1158/2159-8290.CD-24-0102
10.1101/2021.10.26.465897
10.1038/s43018-024-00768-3
10.1101/2023.04.17.535914 | [
"Sytsma",
"Allain",
"Bourke",
"Faizee",
"Fathi",
"Berdeaux",
"Ferreira",
"Brewer",
"Li",
"Pan",
"Rothrock",
"Nyberg",
"Li",
"Wilson",
"Eyquem",
"Pawell"
] | [
"Indee Labs, Berkeley, CA, USA.",
"Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.\nDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.\nUniversité Paris Cité, INSERM UMR976, Hôpital Saint-Louis, Paris, France.",
"Indee Labs, Berkeley, CA, USA.",
"Indee Labs, Berkeley, CA, USA.",
"CellChorus, Houston, TX, United States.",
"CellChorus, Houston, TX, United States.",
"Indee Labs, Berkeley, CA, USA.\nDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.\nDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.\nHollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.",
"Indee Labs, Berkeley, CA, USA.",
"Indee Labs, Berkeley, CA, USA.",
"Indee Labs, Berkeley, CA, USA.",
"Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.\nDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.",
"Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.\nDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.",
"Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.\nDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.",
"Indee Labs, Berkeley, CA, USA.",
"Indee Labs, Berkeley, CA, USA.\nGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.\nDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.\nUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.\nInstitute for Human Genetics (IHG), University of California, San Francisco, San Francisco, CA, USA.\nParker Institute for Cancer Immunotherapy, San Francisco, CA, USA.\nDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.",
"Indee Labs, Berkeley, CA, USA."
] | [
"38979201",
"31167925",
"31073403",
"25317870",
"21830940",
"30309857",
"30413526",
"27111235",
"28924019",
"27347557",
"34662233",
"36713414",
"30528964",
"32067497",
"34002066",
"29436394",
"28225754",
"18688285",
"29039115",
"35452075",
"26216948",
"34616392",
"25517468",
"12648161",
"32269260",
"38583184",
"32029687",
"36045296",
"17085816",
"36008610",
"37704904",
"21445734",
"8547324",
"23555950",
"24910411",
"34147013",
"31647675",
"33941482",
"34725429",
"30275435",
"34568831",
"30824814",
"34083685",
"37147433",
"26059718",
"30084956",
"35881486",
"38750245",
"31646063",
"35110735",
"37714135",
"38868778",
"33594744",
"30052023",
"8315568",
"31488817",
"31022687",
"32839156",
"31800160",
"17296790",
"26086965",
"36816749",
"27076371"
] | [] | 8.927202 | 3.05925 |
38978106 | 750 | Rapidly-manufactured CD276 CAR-T cells exhibit enhanced persistence and efficacy in pancreatic cancer. | Pancreatic cancer is one of the most lethal malignancies and the lack of treatment options makes it more deadly. Chimeric Antigen Receptor T-cell (CAR-T) immunotherapy has revolutionized cancer treatment and made great breakthroughs in treating hematological malignancies, however its success in treating solid cancers remains limited mainly due to the lack of tumor-specific antigens. On the other hand, the prolonged traditional manufacturing process poses challenges, taking 2 to 6 weeks and impacting patient outcomes. CD276 has recently emerged as a potential therapeutic target for anti-solid cancer therapy. Here, we investigated the efficacy of CD276 CAR-T and rapidly-manufactured CAR-T against pancreatic cancer.
In the present study, CD276 CAR-T was prepared by CAR structure carrying 376.96 scFv sequence, CD8 hinge and transmembrane domain, 4-1BB and CD3ζ intracellular domains. Additionally, CD276 rapidly-manufactured CAR-T (named CD276 Dash CAR-T) was innovatively developed by shortening the duration of ex vitro culture to reduce CAR-T manufacturing time. We evaluated the anti-tumor efficacy of CD276 CAR-T and further compared the functional assessment of Dash CAR-T and conventional CAR-T in vitro and in vivo by detecting the immunophenotypes, killing ability, expansion capacity and tumor-eradicating effect of CAR-T.
We found that CD276 was strongly expressed in multiple solid cancer cell lines and that CD276 CAR-T could efficiently kill these solid cancer cells. Moreover, Dash CAR-T was successfully manufactured within 48-72 h and the functional validation was carried out subsequently. In vitro, CD276 Dash CAR-T possessed a less-differentiated phenotype and robust proliferative ability compared to conventional CAR-T. In vivo xenograft mouse model, CD276 Dash CAR-T showed enhanced anti-pancreatic cancer efficacy and T cell expansion. Besides, except for the high-dose group, the body weight of mice was maintained stable, and the state of mice was normal.
In this study, we proved CD276 CAR-T exhibited powerful activity against pancreatic cancer cells in vitro and in vivo. More importantly, we demonstrated the manufacturing feasibility, acceptable safety and superior anti-tumor efficacy of CD276 Dash CAR-T generated with reduced time. The results of the above studies indicated that CD276 Dash CAR-T immunotherapy might be a novel and promising strategy for pancreatic cancer treatment. | [
0.003153936704620719,
-0.01728738844394684,
0.03915391117334366,
0.07539382576942444,
-0.017784617841243744,
0.0024413377977907658,
0.006596960127353668,
0.05513462796807289,
0.04017149657011032,
-0.006417726166546345,
-0.01307828538119793,
-0.010360869579017162,
-0.030458182096481323,
0.00614020274952054,
0.026202823966741562,
-0.02143867500126362,
0.018883148208260536,
-0.028908677399158478,
-0.004506862722337246,
0.0046514058485627174,
0.009418446570634842,
-0.011118276976048946,
-0.0028937584720551968,
-0.010904353111982346,
-0.03316403552889824,
0.015286908484995365,
-0.002851841039955616,
-0.006070822011679411,
-0.01348300650715828,
-0.024005765095353127,
0.02014356665313244,
-0.02550901658833027,
-0.029509976506233215,
-0.03704936057329178,
0.006047694943845272,
0.047086451202631,
0.034065984189510345,
0.014489028602838516,
-0.026295332238078117,
-0.010158509016036987,
0.02733604423701763,
0.029718119651079178,
0.024953968822956085,
0.10610640794038773,
-0.03512982279062271,
-0.03235458955168724,
-0.02486146241426468,
-0.03443601727485657,
0.0268272515386343,
0.005122617352753878,
-0.002156587317585945,
0.023867003619670868,
-0.032447099685668945,
0.032423973083496094,
-0.028052980080246925,
0.007886286824941635,
-0.037373136729002,
0.03383471444249153,
-0.001987471478059888,
0.02604093588888645,
0.018489990383386612,
-0.052775681018829346,
0.010470722801983356,
-0.0010710664791986346,
-0.04435747489333153,
-0.023982638493180275,
-0.05596719682216644,
-0.01178317703306675,
-0.00739483954384923,
-0.04630013555288315,
0.022768473252654076,
-0.014812805689871311,
-0.023867003619670868,
0.024468304589390755,
0.0211380235850811,
0.007198260631412268,
0.018663441762328148,
0.011309074237942696,
-0.013402062468230724,
0.02537025511264801,
0.044634997844696045,
0.005761499051004648,
-0.005949405487626791,
-0.04003273695707321,
-0.02008574828505516,
-0.015703193843364716,
0.015818828716874123,
-0.07395996153354645,
-0.011476744897663593,
0.0002983013982884586,
0.0009944584453478456,
0.013205483555793762,
0.0014129115734249353,
0.03022691234946251,
-0.006313655059784651,
0.024930842220783234,
-0.016674524173140526,
-0.019553828984498978,
0.029856881126761436,
0.024352669715881348,
0.054255805909633636,
0.012442294508218765,
-0.025416508316993713,
-0.035176075994968414,
0.025277746841311455,
-0.02550901658833027,
-0.04616137593984604,
0.009430009871721268,
0.023173194378614426,
0.014523719437420368,
0.07220230996608734,
-0.01348300650715828,
-0.02715102955698967,
0.038783881813287735,
-0.025069603696465492,
-0.05009295418858528,
-0.025069603696465492,
0.003879544325172901,
0.0071057528257369995,
0.012962650507688522,
-0.058603670448064804,
0.008851836435496807,
0.026087189093232155,
-0.04486626759171486,
-0.01577257364988327,
-0.033580318093299866,
0.051434315741062164,
-0.02089519239962101,
-0.03369595482945442,
-0.07136973738670349,
0.015044075436890125,
-0.00862634927034378,
0.01276607159525156,
-0.03806694597005844,
-0.042206667363643646,
0.013529260642826557,
-0.013124539516866207,
-0.007417966611683369,
-0.02617969736456871,
0.0300650242716074,
-0.006255837623029947,
-0.023658860474824905,
0.0017533112550154328,
0.005657427944242954,
-0.04648515209555626,
-0.04664704203605652,
-0.027081647887825966,
0.030203785747289658,
-0.01644325442612171,
0.023520098999142647,
-0.03758127987384796,
0.05296069383621216,
0.0960230603814125,
-0.02054828777909279,
0.013459879904985428,
-0.031175116077065468,
0.004582025110721588,
0.046068865805864334,
-0.03526858612895012,
-0.07460751384496689,
-0.01852468028664589,
-0.0024847008753567934,
-0.04519004374742508,
-0.0046514058485627174,
0.018975654616951942,
0.008395079523324966,
-0.037812549620866776,
-0.01147096324712038,
-0.07853909581899643,
-0.024352669715881348,
0.008233191445469856,
-0.03704936057329178,
-0.02879304252564907,
-0.02108020707964897,
-0.021531183272600174,
0.004616715479642153,
-0.00866682082414627,
0.002617680700495839,
-0.03804381936788559,
-0.033233415335416794,
-0.0011122613213956356,
0.00922186765819788,
0.03466728329658508,
-0.030990101397037506,
-0.01100264210253954,
0.026711616665124893,
-0.005290288012474775,
0.018513116985559464,
-0.04271546006202698,
0.002027943730354309,
0.00816959235817194,
-0.007655017543584108,
0.009823168627917767,
-0.0016767032211646438,
-0.009135141968727112,
-0.012153207324445248,
0.05249815806746483,
0.01725269854068756,
0.007944104261696339,
-0.010915916413068771,
0.01283545233309269,
-0.0005492648342624307,
-0.04972292482852936,
0.02243313379585743,
0.004281375091522932,
0.0015220418572425842,
-0.0585111603140831,
0.03526858612895012,
-0.029486849904060364,
-0.03138326108455658,
0.04604573920369148,
0.012777634896337986,
-0.006729939952492714,
-0.0021190058905631304,
-0.00799614004790783,
-0.02828424982726574,
0.008637912571430206,
0.04907536879181862,
0.048705339431762695,
0.008892308920621872,
-0.01895252801477909,
-0.0055851563811302185,
-0.01728738844394684,
-0.002578653860837221,
-0.019750408828258514,
0.010678865015506744,
-0.0011946510057896376,
-0.01267356425523758,
0.010453377850353718,
-0.011494089849293232,
-0.023335084319114685,
-0.00958611723035574,
0.0037639096844941378,
-0.008551186881959438,
-0.03510669618844986,
-0.02809923328459263,
0.020363271236419678,
0.010707774199545383,
0.03809007257223129,
-0.022745346650481224,
0.02567090466618538,
0.035199206322431564,
0.02259502187371254,
0.0008730420377105474,
-0.017853999510407448,
0.0070884074084460735,
-0.024514557793736458,
-0.07095345854759216,
0.009551426395773888,
-0.01968102715909481,
0.02763669565320015,
0.0034083330538123846,
-0.018166212365031242,
-0.016836414113640785,
0.03469041362404823,
0.011320637539029121,
0.006689467933028936,
-0.026595981791615486,
-0.014338703826069832,
-0.005226688925176859,
-0.026896633207798004,
0.042669206857681274,
-0.028862422332167625,
-0.051943108439445496,
-0.04190601781010628,
0.04660078510642052,
0.01633918471634388,
0.015148147009313107,
0.013205483555793762,
-0.01069042831659317,
0.05735481530427933,
-0.0028026963118463755,
0.05120304971933365,
0.011679105460643768,
-0.07210980355739594,
0.017992760986089706,
-0.017911816015839577,
0.048381559550762177,
-0.011014205403625965,
0.011251256801187992,
-0.03478292003273964,
-0.006735721603035927,
-0.005316305439919233,
-0.023624170571565628,
-0.006585396360605955,
-0.002064079511910677,
0.05508837476372719,
-0.017368333414196968,
0.01809683069586754,
-0.05166558548808098,
0.0029891571030020714,
-0.02302286960184574,
0.00442880904302001,
-0.0015408324543386698,
-0.005830880254507065,
-0.03864511847496033,
-0.02054828777909279,
0.009094669483602047,
-0.02208622917532921,
0.012037573382258415,
-0.016211986541748047,
-0.002374847885221243,
-0.009476264007389545,
-0.0348985530436039,
0.02046734280884266,
0.010829190723598003,
-0.01170223206281662,
-0.0243757963180542,
0.00591182429343462,
0.04158224165439606,
0.0019715717062354088,
-0.013887728564441204,
0.03360344469547272,
-0.011522998102009296,
0.02453768439590931,
-0.0002936037490144372,
0.018964091315865517,
-0.04680892825126648,
-0.009308594278991222,
-0.03492167964577675,
-0.03547672927379608,
-0.012130080722272396,
-0.03191518038511276,
-0.0087477657943964,
0.01887158490717411,
-0.01720644347369671,
0.028839295729994774,
-0.0049751834012568,
0.046577658504247665,
-0.04280797019600868,
0.027220409363508224,
-0.056661006063222885,
0.044126205146312714,
-0.03864511847496033,
-0.01798119768500328,
-0.011008423753082752,
0.004946274682879448,
-0.0682707279920578,
-0.006533361040055752,
0.006510233972221613,
0.037141866981983185,
0.022814728319644928,
-0.01895252801477909,
0.04697081819176674,
0.010956388898193836,
0.02261814847588539,
0.007707053329795599,
0.039408307522535324,
0.01182364858686924,
0.05462583526968956,
0.018894711509346962,
0.02162368968129158,
0.015020948834717274,
0.03055069036781788,
0.012546366080641747,
0.02728979103267193,
-0.01234978623688221,
-0.03864511847496033,
0.025740286335349083,
-0.009643934667110443,
0.018732821568846703,
0.017530221492052078,
-0.03582363203167915,
0.03607802838087082,
0.015726320445537567,
0.04801153019070625,
-0.03233146294951439,
0.018247157335281372,
-0.047063324600458145,
-0.029047438874840736,
0.005460849031805992,
-0.012026009149849415,
0.03462103009223938,
-0.0021190058905631304,
-0.05448707565665245,
0.00543194031342864,
0.0183049738407135,
0.01765741966664791,
-0.0020467343274503946,
-0.015680065378546715,
0.07840032875537872,
-0.05009295418858528,
0.011257038451731205,
0.0009503727196715772,
-0.009499391540884972,
0.009753787890076637,
0.04976917803287506,
-0.018732821568846703,
-0.05749357491731644,
0.01833966374397278,
-0.006602741777896881,
-0.013193920254707336,
0.02992626279592514,
-0.005131290294229984,
-0.03073570504784584,
0.041397225111722946,
0.02456081099808216,
0.049352891743183136,
0.03873762860894203,
0.0333721749484539,
0.00981160532683134,
-0.0003452780074439943,
-0.0260178092867136,
-0.047363974153995514,
0.04694769158959389,
-0.019866041839122772,
0.013032031245529652,
-0.0002121174184139818,
0.016431691125035286,
-0.010326179675757885,
0.017298951745033264,
0.010395560413599014,
0.0398477204144001,
-0.006724158301949501,
0.02634158544242382,
-0.024028891697525978,
-0.017599603161215782,
0.02812235988676548,
-0.032123319804668427,
0.016003843396902084,
0.0050821453332901,
-0.03240084648132324,
-0.03994022682309151,
0.008880745619535446,
-0.02456081099808216,
0.046091992408037186,
0.02927870862185955,
0.04093468561768532,
-0.004576243460178375,
-0.0333259217441082,
0.01992386020720005,
0.07442249357700348,
0.013506134040653706,
-0.01655888929963112,
-0.021935904398560524,
0.038136325776576996,
-0.059898778796195984,
0.0085222776979208,
-0.0504167303442955,
0.025601524859666824,
-0.03022691234946251,
-0.007689707912504673,
0.039570197463035583,
-0.016292929649353027,
-0.01571475714445114,
-0.006966990884393454,
-0.0015755228232592344,
0.04565258324146271,
-0.005270051769912243,
-0.003801490878686309,
0.027590440586209297,
-0.011008423753082752,
-0.015841955319046974,
0.021831832826137543,
-0.05707729235291481,
-0.026272205635905266,
0.054209548979997635,
-0.03873762860894203,
-0.0150325121358037,
0.02523149363696575,
0.05393202602863312,
-0.03448227047920227,
-0.009892549365758896,
-0.032909639179706573,
0.0019498902838677168,
0.018860019743442535,
0.06128639355301857,
-0.01100264210253954,
0.023092251271009445,
-0.02051359787583351,
0.024630192667245865,
-0.02202841080725193,
-0.017137063667178154,
0.029486849904060364,
-0.03168391063809395,
0.047734007239341736,
-0.002259213011711836,
0.020016368478536606,
0.02138085663318634,
0.033094651997089386,
-0.022444697096943855,
-0.03284025564789772,
-0.03184579685330391,
0.026896633207798004,
0.05074051022529602,
0.02941747009754181,
-0.0036858562380075455,
-0.017403023317456245,
-0.03432038053870201,
0.003983615431934595,
0.024098273366689682,
0.013945546001195908,
-0.01536785252392292,
-0.010048655793070793,
-0.01154034398496151,
0.011019987985491753,
0.0032869165297597647,
-0.027243537828326225,
-0.010644175112247467,
0.014997821301221848,
0.004512644372880459,
0.0430854931473732,
0.03966270387172699,
0.020074184983968735,
0.021750887855887413,
0.020155129954218864,
0.003622257150709629,
0.04486626759171486,
-0.013425189070403576,
0.01341362576931715,
-0.04976917803287506,
-0.017726801335811615,
0.020536724478006363,
-0.00012277154019102454,
-0.050786763429641724,
0.012453857809305191,
-0.034852299839258194,
0.00032847485272213817,
0.010829190723598003,
-0.01527534518390894,
0.0049867467023432255,
0.01062104757875204,
-0.00946470070630312,
0.006053477060049772,
-0.029163073748350143,
-0.016489509493112564,
-0.025462761521339417,
-0.02342759072780609,
-0.040564656257629395,
-0.03270149603486061,
0.030041897669434547,
-0.010389778763055801,
0.019125981256365776,
0.028376756235957146,
-0.030527561902999878,
-0.014419647864997387,
-0.02283785492181778,
0.01698673889040947,
0.0028619589284062386,
-0.00904841534793377,
0.033256541937589645,
0.00019965054525528103,
0.01566850207746029,
-0.005888697225600481,
0.010962170548737049,
-0.002994938986375928,
0.03577737882733345,
-0.03314090520143509,
0.005937842186540365,
-0.009661279618740082,
0.0032319901511073112,
-0.04012524336576462,
0.012060699984431267,
-0.014038053341209888,
0.011991319246590137,
-0.009655497968196869,
0.0015755228232592344,
-0.05767859145998955,
0.0021204515360295773,
-0.039408307522535324,
-0.02472270093858242,
0.0016275584930554032,
0.023231012746691704,
-0.04417245835065842,
-0.010904353111982346,
0.0009482046007178724,
-0.013136102817952633,
-0.02944059669971466,
-0.05883494019508362,
0.022768473252654076,
-0.0010118036298081279,
0.0033389520831406116,
0.01860562339425087,
-0.0019079726189374924,
0.06540299206972122,
0.0066663408651947975,
-0.04865908622741699,
0.01267356425523758,
-0.03961645066738129,
0.006435071583837271,
-0.030481308698654175,
-0.0038737626746296883,
-0.01771523617208004,
0.05823363736271858,
0.00975956954061985,
0.02863115258514881,
-0.01854780688881874,
-0.0018501552985981107,
-0.015263780951499939,
0.0025670905597507954,
0.021103333681821823,
-0.0020770884584635496,
0.020640796050429344,
0.014465902000665665,
-0.02599468268454075,
0.026087189093232155,
0.019530702382326126,
0.0003317270602565259,
-0.001360153197310865,
-0.009857858531177044,
0.009904112666845322,
0.013818347826600075,
-0.010019747540354729,
-0.06429290026426315,
-0.02330039255321026,
0.006718376651406288,
0.019970113411545753,
0.007319677155464888,
-0.022167174145579338,
0.012095389887690544,
0.0162813663482666,
0.04861282929778099,
-0.02925558015704155,
-0.002224522642791271,
0.05351574346423149,
0.02221342734992504,
-0.03693372383713722,
-0.00212623318657279,
0.015587558038532734,
-0.010488067753612995,
-0.013540823943912983,
-0.020941445603966713,
0.010372432880103588,
-0.019021909683942795,
-0.00008288659591926262,
-0.028353629633784294,
0.002185496035963297,
-0.00804817583411932,
0.019368814304471016,
0.0025757630355656147,
0.00419175811111927,
0.0012727044522762299,
-0.033742208033800125,
0.009661279618740082,
0.006909173913300037,
-0.03191518038511276,
-0.0017504204297438264,
-0.018235594034194946,
-0.02313850447535515,
-0.005067691206932068,
-0.030157530680298805,
0.005339432507753372,
0.00038087181746959686,
-0.04162849485874176,
0.013274864293634892,
0.003636711509898305,
-0.01519440021365881,
-0.021669944748282433,
0.014292449690401554,
-0.019565392285585403,
-0.007504692301154137,
-0.03880700841546059,
0.00703058997169137,
-0.006290527991950512,
0.013506134040653706,
0.0017041665269061923,
0.013887728564441204,
-0.019935423508286476,
0.046253882348537445,
0.05619846656918526,
-0.011921938508749008,
0.024190779775381088,
0.019854478538036346,
-0.03543047234416008,
-0.022386878728866577,
-0.006729939952492714,
-0.010615265928208828,
-0.008337262086570263,
0.02456081099808216,
-0.007579855155199766,
0.07354367524385452,
0.03126762434840202,
0.011170312762260437,
-0.01663983426988125,
-0.02156587317585945,
0.0010609484743326902,
-0.0121878981590271,
-0.007886286824941635,
-0.02893180400133133,
0.030273165553808212,
-0.009002162143588066,
0.02631845884025097,
0.0007443984504789114,
0.019368814304471016,
-0.001738856895826757,
-0.003125027986243367,
0.0015234872698783875,
0.035361092537641525,
-0.01000240258872509,
0.0032551169861108065,
-0.00414550444111228,
0.004052996635437012,
-0.0439411886036396,
0.0009127914672717452,
-0.01650107279419899,
-0.01084075402468443,
0.0031568275298923254,
0.0036338206846266985,
-0.04033338651061058,
-0.06406162679195404,
-0.0029298944864422083,
-0.0020250529050827026,
0.011667542159557343,
-0.02108020707964897,
0.007643454242497683,
-0.015737883746623993,
0.0017562020802870393,
-0.0324702262878418,
0.009933020919561386,
0.023554788902401924,
0.01795806922018528,
-0.013598641380667686,
-0.04407995194196701,
-0.03223895654082298,
0.004365209955722094,
0.022930363193154335,
-0.01962321065366268,
0.031799543648958206,
-0.017588037997484207,
0.02728979103267193,
-0.012453857809305191,
0.0024818098172545433,
-0.027104774489998817,
-0.002684170613065362,
0.0438949353992939,
0.023820750415325165,
0.0024398923851549625,
0.035546109080314636,
-0.0013962890952825546,
0.005732590798288584,
-0.0066663408651947975,
-0.04125846177339554,
-0.023797621950507164,
-0.048520322889089584,
-0.02976437285542488,
-0.013355808332562447,
-0.03073570504784584,
-0.009615025483071804,
0.022571895271539688,
0.006683685816824436,
0.031244497746229172,
0.0008643694454804063,
-0.002489037113264203,
-0.003200190607458353,
-0.04183663800358772,
0.013459879904985428,
0.015946026891469955,
-0.0027622240595519543,
0.006880265194922686,
-0.03482917323708534,
0.029371215030550957,
0.007389057893306017,
-0.01252323854714632,
0.0037610188592225313,
-0.004475063178688288,
-0.03966270387172699,
-0.0004741023003589362,
0.008163810707628727,
-0.002087206346914172,
-0.022872544825077057,
0.009562990628182888,
-0.017241135239601135,
-0.0008101656567305326,
0.0031279188115149736,
-0.0036714018788188696,
0.013101411983370781,
0.009904112666845322,
0.008250536397099495,
-0.01903347298502922,
0.05101803317666054,
0.025000223889946938,
-0.005064800381660461,
0.00241965614259243,
-0.0013023358769714832,
0.019646337255835533,
0.003518186043947935,
-0.016165731474757195,
0.007712834980338812,
-0.002357502467930317,
0.011725359596312046,
-0.0009966266807168722,
0.053238220512866974,
-0.020421089604496956,
0.03869137167930603,
0.0010269806953147054,
-0.039917100220918655,
-0.005544684361666441,
0.013760530389845371,
-0.04847406968474388,
0.014569972641766071,
-0.03360344469547272,
0.07525506615638733,
-0.03605490177869797,
0.048705339431762695,
-0.003220426617190242,
0.026225950568914413,
0.04327050596475601,
-0.10018590837717056,
-0.03501418977975845,
-0.03630929812788963,
-0.020744865760207176,
-0.012326659634709358,
0.005455067381262779,
-0.02798359841108322,
-0.011910375207662582,
-0.0049260384403169155,
-0.035037316381931305,
0.03089759312570095,
-0.00041953715845011175,
0.01527534518390894,
0.0036020211409777403,
0.0006695972406305373,
0.01365645881742239,
-0.011777394451200962,
-0.06614305078983307,
0.0023632843513041735,
0.03709561377763748,
-0.0365636944770813,
-0.0007928204722702503,
0.010967952199280262,
0.04243793711066246,
-0.0006858583656139672,
-0.015090329572558403,
-0.015182836912572384,
-0.004694769158959389,
-0.0251852385699749,
-0.03073570504784584,
0.023439155891537666,
0.012789198197424412,
-0.036633074283599854,
0.012731380760669708,
-0.010141164064407349,
-0.014361830428242683,
0.006961209233850241,
-0.01318235695362091,
0.0010645620059221983,
0.0031886270735412836,
0.011644414626061916,
-0.01495156716555357,
0.0030036114621907473,
-0.005937842186540365,
-0.00986942183226347,
-0.01071933750063181,
-0.029671866446733475,
0.00785737857222557,
0.00691495556384325,
-0.005186216440051794,
0.013263300992548466,
-0.015286908484995365,
-0.04569883644580841,
0.0023531662300229073,
-0.022872544825077057,
-0.021045517176389694,
-0.008077084086835384,
0.011025769636034966,
0.01211851742118597,
0.01512501947581768,
-0.025092732161283493,
0.06373784691095352,
-0.01472029834985733,
-0.014396521262824535,
0.007169351913034916,
-0.01447746530175209,
-0.04650827869772911,
0.021901212632656097,
-0.03809007257223129,
0.018813766539096832,
-0.004868221003562212,
0.013286427594721317,
-0.03667932748794556,
0.00018826776067726314,
0.002994938986375928,
-0.0034372417721897364,
-0.04063403606414795,
-0.004819076508283615,
0.030596943572163582,
0.003018065821379423,
0.022120919078588486,
-0.021658381447196007,
-0.020744865760207176,
-0.004952056333422661,
-0.025624651461839676,
-0.017194880172610283,
-0.028561772778630257,
0.0101642906665802,
0.02798359841108322,
-0.015460359863936901,
-0.022583458572626114,
-0.02567090466618538,
-0.020455779507756233,
-0.0034661502577364445,
-0.017969632521271706,
-0.030365673825144768,
-0.0023112487979233265,
-0.017113937065005302,
0.011898810975253582,
-0.021993720903992653,
0.04003273695707321,
-0.03677183762192726,
-0.024144526571035385,
-0.02796047180891037,
-0.023658860474824905,
-0.006689467933028936,
0.031475767493247986,
-0.01399179920554161,
-0.002171041676774621,
-0.009158268570899963,
0.04417245835065842,
0.0174955315887928,
0.010823408141732216,
-0.030596943572163582,
0.011968191713094711,
0.007470001932233572,
0.03198456019163132,
-0.022803165018558502,
-0.007140443194657564,
-0.02016669325530529,
0.06165642663836479,
-0.004475063178688288,
0.02299974299967289,
0.014835933223366737,
-0.009123578667640686,
-0.02219030074775219,
0.008499151095747948,
0.03272462263703346,
-0.00009603101352695376,
-0.00662586884573102,
0.02143867500126362,
0.024352669715881348,
0.015356289222836494,
-0.005854006856679916,
-0.012997341342270374,
0.03462103009223938,
0.04259982705116272,
-0.005116835702210665,
-0.016385437920689583,
0.01660514436662197,
-0.010545885190367699,
-0.003197299549356103,
-0.007400621194392443,
-0.008296790532767773,
0.029348088428378105,
0.009615025483071804,
-0.07372868806123734,
0.01599228009581566,
-0.012338222935795784,
-0.012130080722272396,
-0.04442685469985008,
0.03547672927379608,
0.058603670448064804,
0.05328447371721268,
-0.024306414648890495,
0.023681987076997757,
-0.007944104261696339,
-0.04565258324146271,
-0.01283545233309269,
0.018755950033664703,
-0.018536243587732315,
0.037974435836076736,
0.0006648995913565159,
-0.019877607002854347,
0.025809666141867638,
0.013980235904455185,
-0.028029853478074074,
0.01876751333475113,
0.0036049119662493467,
0.0039431434124708176,
0.01652419939637184,
-0.02976437285542488,
0.03691059723496437,
-0.013459879904985428,
0.007903631776571274,
0.010360869579017162,
0.009094669483602047,
-0.0026277988217771053,
0.004902911372482777,
0.022560331970453262,
-0.016628270968794823,
-0.0050850361585617065,
0.026757871732115746,
0.017518658190965652,
0.04278483986854553,
-0.016859540715813637,
0.02146180160343647,
-0.01680172234773636,
0.04079592600464821,
-0.0012575273867696524,
-0.022826291620731354,
-0.022479387000203133,
0.009302811697125435,
0.037997566163539886,
0.033927224576473236,
-0.02129991352558136,
-0.015356289222836494,
0.023115377873182297,
-0.03709561377763748,
-0.03501418977975845,
-0.03126762434840202,
0.037326883524656296,
0.025601524859666824,
-0.00556202931329608,
0.00845289696007967,
0.016373874619603157,
-0.004712114110589027,
-0.03445914387702942,
-0.022363752126693726,
0.06378410756587982,
0.010326179675757885,
0.02502335049211979,
-0.029070565477013588,
0.041212208569049835,
0.020756429061293602,
0.0038246179465204477,
0.037488773465156555,
0.02486146241426468,
-0.05476459860801697,
-0.009314375929534435,
-0.03429725393652916,
-0.024422049522399902,
-0.022872544825077057,
-0.004211994353681803,
-0.021369293332099915,
-0.01631605625152588,
0.02016669325530529,
0.02097613550722599,
-0.02604093588888645,
0.023057561367750168,
-0.013818347826600075,
0.00827944464981556,
-0.009123578667640686,
0.008181155659258366,
-0.021912777796387672,
0.014639354310929775,
-0.045768216252326965,
0.001769211026839912,
0.029810627922415733,
-0.004980965051800013,
0.04667016863822937,
0.012488548643887043,
0.0199007336050272,
-0.023797621950507164,
-0.03482917323708534,
0.012904833070933819,
0.007944104261696339,
-0.04764150083065033,
-0.024445176124572754,
-0.010447596199810505,
0.02083737403154373,
-0.007244514301419258,
0.013887728564441204,
0.009418446570634842,
0.03561548888683319,
0.01674390584230423,
0.02553214319050312,
0.02728979103267193,
0.026133444160223007,
0.0026971795596182346,
0.0054088132455945015,
0.005966750904917717,
-0.0019065272063016891,
-0.012604182586073875,
0.028700534254312515,
0.0005550466012209654,
-0.014708735048770905,
-0.005509993992745876,
0.01447746530175209,
0.06683686375617981,
0.016616707667708397,
0.01141892746090889,
-0.020767994225025177,
-0.004743913654237986,
0.012049136683344841,
-0.04842781648039818,
0.007868941873311996,
0.002509273122996092,
-0.014940003864467144,
-0.005533120594918728,
0.015044075436890125,
0.02221342734992504,
-0.026757871732115746,
0.017518658190965652,
0.034227874130010605,
0.015518177300691605,
-0.029694993048906326,
-0.00850493274629116,
0.025254620239138603,
-0.038621991872787476,
-0.03168391063809395,
-0.01668608747422695,
-0.007076844107359648,
-0.003856417490169406,
-0.002095879055559635,
-0.03221582993865013,
-0.020999262109398842,
-0.012627310119569302,
0.012245715595781803,
-0.014512156136333942,
0.008591658435761929,
0.04953790828585625,
-0.005989877972751856,
-0.016836414113640785,
0.025601524859666824,
-0.026272205635905266,
-0.018813766539096832,
-0.06595803797245026,
0.04014836996793747,
0.011898810975253582,
-0.03917703777551651,
-0.017218008637428284,
0.0014786787796765566,
0.023705115541815758,
0.008412424474954605,
0.012014445848762989,
0.0030122841708362103,
0.0012235597241669893,
0.01166176050901413,
0.015182836912572384,
0.00455022556707263,
0.01139001827687025,
0.021369293332099915,
-0.022571895271539688,
-0.06864076107740402,
0.011968191713094711,
0.0032175357919186354,
-0.012072263285517693,
0.004235120955854654,
-0.029463723301887512,
0.01822402887046337,
-0.02911681868135929,
-0.0043883370235562325,
0.007053717039525509,
0.0035817851312458515,
0.007724398281425238,
0.009239212609827518,
-0.013922418467700481,
-0.016292929649353027,
0.021935904398560524,
0.0017128391191363335,
0.00555335683748126,
-0.010441813617944717,
0.041859764605760574,
0.00999083835631609,
0.013598641380667686,
-0.004347865004092455,
-0.0008932781056500971,
-0.016616707667708397,
0.008562750183045864,
0.05490335822105408,
-0.031313877552747726,
-0.004376773722469807,
0.06327531486749649,
0.00986942183226347,
-0.003908453043550253,
-0.028237994760274887,
0.013263300992548466,
0.024768954142928123,
-0.0039229076355695724,
-0.0014512155903503299,
0.017275825142860413,
-0.002434110501781106,
-0.005113944876939058,
0.015946026891469955,
0.0011614060495048761,
-0.023311957716941833,
-0.042854223400354385,
0.008013484999537468,
-0.008597440086305141,
0.03189205378293991,
0.04502815380692482,
-0.02205153927206993,
0.004694769158959389,
-0.013795220293104649,
0.027659822255373,
0.03704936057329178,
-0.006307873409241438,
-0.011627069674432278,
0.04093468561768532,
0.030111277475953102,
-0.015148147009313107,
-0.009470482356846333,
-0.02569403126835823,
-0.019484447315335274,
0.003743673674762249,
-0.03445914387702942,
0.002622016938403249,
0.005038782488554716,
-0.009412664920091629,
-0.000627318280749023,
-0.017379896715283394,
0.0043999007903039455,
-0.02523149363696575,
0.01790025271475315,
-0.023254139348864555,
-0.01182364858686924,
-0.0003393155930098146,
0.02340446412563324,
0.000904118875041604,
-0.02089519239962101,
-0.03906140476465225,
0.007383276242762804,
0.004041432868689299,
0.01636231131851673,
0.02259502187371254,
0.00002134273381670937,
0.012465421110391617,
0.009458919055759907,
0.03071257844567299,
-0.028816169127821922,
0.013887728564441204,
-0.07437624037265778,
0.017518658190965652,
-0.018258720636367798,
-0.015182836912572384,
-0.040564656257629395,
-0.030134404078125954,
-0.050648000091314316,
0.0038448539562523365,
0.023936383426189423,
0.012881706468760967,
-0.0029385669622570276,
-0.025300873443484306,
-0.009244995191693306,
0.030319420620799065,
0.011765831150114536,
0.021959031000733376,
-0.031175116077065468,
0.026549728587269783,
0.0008715966250747442,
-0.024121399968862534,
0.0064466348849236965,
-0.007834251038730145,
-0.04810403659939766,
0.03885326161980629,
-0.02763669565320015,
0.0251852385699749,
-0.014708735048770905,
0.02680412493646145,
0.020212946459650993,
-0.007973013445734978,
0.03642493113875389,
0.014535282738506794,
-0.00922186765819788,
-0.015680065378546715,
-0.010725119151175022,
-0.00004194016582914628,
0.03304839879274368,
0.03450539708137512,
0.014199942350387573,
0.024583939462900162,
-0.011100932024419308,
-0.006585396360605955,
-0.03686434403061867,
0.03383471444249153,
-0.04694769158959389,
-0.02925558015704155,
0.004044323693960905,
-0.004660078790038824,
-0.029463723301887512,
0.014489028602838516,
0.0050850361585617065,
0.014419647864997387,
0.0068687014281749725,
0.0016897121677175164,
-0.006099730730056763,
0.0065622697584331036,
-0.030620070174336433,
0.013668022118508816,
0.004584915935993195,
0.01901034638285637,
0.03725750371813774,
0.0017272934783250093,
0.009620807133615017,
-0.02939434163272381,
0.027590440586209297,
0.008568531833589077,
-0.01293952390551567,
-0.013529260642826557,
-0.03887638822197914,
-0.021496491506695747,
-0.002403756370767951,
-0.002556972438469529,
0.0059262788854539394,
0.03753502666950226,
-0.02186652272939682,
-0.022398442029953003,
0.04616137593984604,
0.005619846750050783,
-0.01334424503147602,
0.0006695972406305373,
-0.003616475500166416,
-0.010349306277930737,
0.006880265194922686,
0.0011505653383210301,
0.000014183319763105828,
0.0023126942105591297,
0.001799565157853067,
0.017021428793668747,
-0.003205972258001566,
0.01011225488036871,
0.02553214319050312,
-0.0170445553958416,
-0.009742223657667637,
-0.031637657433748245,
-0.022282807156443596,
-0.041882891207933426,
0.0032926981803029776,
-0.001504696672782302,
-0.02631845884025097,
-0.014489028602838516,
-0.02221342734992504,
0.014523719437420368,
-0.01259261928498745,
-0.017784617841243744,
0.007973013445734978,
0.036633074283599854,
-0.00479305861517787,
-0.018235594034194946,
0.0005427604191936553,
0.010736682452261448,
0.024260161444544792,
-0.02310381457209587,
0.020536724478006363,
-0.01757647469639778,
-0.0085222776979208,
0.028839295729994774,
-0.039732083678245544,
0.021392419934272766,
0.019125981256365776,
-0.019542265683412552,
0.023115377873182297,
-0.0016752578085288405,
0.002867740811780095,
0.0651254653930664,
0.014859059825539589,
-0.009776914492249489,
0.0014150796923786402,
-0.008296790532767773,
-0.019183797761797905,
-0.013818347826600075,
0.030943848192691803,
0.011673323810100555,
0.0005637191934511065,
0.03223895654082298,
0.04005586355924606,
-0.006839792709797621,
-0.015506613999605179,
0.008001921698451042,
0.024190779775381088,
0.009597680531442165,
0.0015813045902177691,
0.013101411983370781,
-0.013922418467700481,
-0.02083737403154373,
0.007337022107094526,
-0.01561068557202816,
-0.019068162888288498,
-0.007672362960875034,
0.02241000533103943,
0.003237771801650524,
-0.017403023317456245,
-0.01023367140442133,
0.012511675246059895,
-0.009123578667640686,
-0.00727342301979661,
-0.01828184723854065,
-0.03672558441758156,
-0.0183049738407135,
-0.0037176557816565037,
-0.00562273757532239,
-0.02229437232017517,
0.024306414648890495,
-0.009291248396039009,
0.02453768439590931,
0.010996860451996326,
-0.0024095382541418076,
-0.0019383267499506474,
-0.00442880904302001,
-0.015448796562850475,
-0.019993240013718605,
-0.008597440086305141,
0.03073570504784584,
-0.020848937332630157,
-0.013494569808244705,
-0.021172715350985527,
0.014269323088228703,
0.017703672870993614,
-0.020744865760207176,
-0.08760485053062439,
-0.002517945831641555,
0.019310995936393738,
0.01437339372932911,
0.021473364904522896,
0.03464415669441223,
-0.00862634927034378,
0.0037147649563848972,
-0.044473107904195786,
-0.015599122270941734,
-0.014905313961207867,
0.03954707086086273,
-0.0013565396657213569,
-0.0033736424520611763,
-0.018721258267760277,
-0.010308833792805672,
0.015286908484995365,
-0.026457220315933228,
-0.047248341143131256,
0.01406117994338274,
-0.031961433589458466,
-0.007932540960609913,
0.006250055972486734,
-0.005995659623295069,
-0.03670245409011841,
0.012268842197954655,
-0.03381158784031868,
-0.024514557793736458,
0.0035413128789514303,
0.018802203238010406,
0.029024312272667885,
0.035361092537641525,
0.018166212365031242,
-0.0077648707665503025,
0.000311852345475927,
-0.0017229571240022779,
-0.002750660525634885,
-0.006874483544379473,
0.0012430731439962983,
0.014130561612546444,
-0.015795700252056122,
0.01876751333475113,
0.0054088132455945015,
-0.04539818689227104,
0.00808864738792181,
-0.009603462181985378,
-0.010013965889811516,
0.02664223685860634,
-0.0536082498729229,
0.015680065378546715,
-0.006955427583307028,
0.002873522462323308,
0.012072263285517693,
0.029810627922415733,
-0.007938322611153126,
0.01647794619202614,
0.005605392623692751,
0.0031134644523262978,
0.020282328128814697,
-0.006070822011679411,
-0.015680065378546715,
0.03901515156030655,
0.011343765072524548,
0.03025003895163536,
0.012453857809305191,
-0.020941445603966713,
-0.018536243587732315,
0.01744927652180195,
0.016674524173140526,
-0.01561068557202816,
0.023416027426719666,
-0.020155129954218864,
0.002110333414748311,
0.03367282822728157,
0.03728063032031059,
0.004527098964899778,
0.008950126357376575,
0.02731291763484478,
-0.016165731474757195,
-0.0223521888256073,
-0.007360149174928665,
0.001388339209370315,
-0.018570933490991592,
-0.0215196181088686,
0.08159185200929642,
-0.01166176050901413,
-0.013263300992548466,
0.010516976937651634,
0.01595759019255638,
-0.033256541937589645,
0.019484447315335274,
-0.0251852385699749,
0.028908677399158478,
-0.03637867793440819,
0.039107657968997955,
0.007990358397364616,
0.0178771261125803,
0.029348088428378105,
0.049352891743183136,
-0.012372913770377636,
0.007776434067636728,
0.04440372809767723,
0.010048655793070793,
0.0027029612101614475,
0.012962650507688522,
0.017160190269351006,
0.005793298594653606,
0.04174412786960602,
-0.02168150804936886,
-0.0007378939772024751,
-0.000948927307035774,
-0.010488067753612995,
0.0037725823931396008,
0.007556728087365627,
0.026780998334288597,
-0.02016669325530529,
0.014269323088228703,
-0.04856657609343529,
-0.0053047421388328075,
0.007180915214121342,
-0.006013004574924707,
-0.006203801836818457,
0.002473137341439724,
0.02553214319050312,
0.0013500351924449205,
-0.0093432841822505,
-0.02796047180891037,
0.009227649308741093,
0.032285209745168686,
0.01478967908769846,
-0.026225950568914413,
0.021149588748812675,
0.018917838111519814,
-0.04683205485343933,
0.012708254158496857,
0.027659822255373,
-0.006394599098712206,
0.026619110256433487,
-0.01495156716555357,
-0.012037573382258415,
-0.008435552008450031,
0.0024153199046850204,
-0.0036800745874643326,
-0.024422049522399902,
0.001513369265012443,
0.039778340607881546,
0.009996620006859303,
0.008632130920886993,
-0.013506134040653706
] | 2024-07-09 | 42 | 38978106 | [
"enhanced anti-pancreatic cancer efficacy",
"pancreatic cancer cells",
"anti-solid cancer therapy",
"pancreatic cancer treatment",
"Pancreatic cancer",
"pancreatic cancer",
"solid cancers",
"multiple solid cancer cell lines",
"cancer treatment",
"CD276 Dash CAR-T immunotherapy",
"superior anti-tumor efficacy",
"CD276 Dash CAR-T",
"CD276",
"CD276 CAR-T",
"Dash CAR-T",
"T cell expansion",
"CD276 Dash CAR-",
"CAR structure",
"Dash CAR-T and conventional CAR-T",
"CAR",
"CD276 CAR-",
"these solid cancer cells",
"treatment options",
"the anti-tumor efficacy",
"impacting patient outcomes",
"vivo xenograft mouse model",
"Chimeric Antigen Receptor T-cell (CAR-T) immunotherapy",
"hematological malignancies",
"reduced time",
"CD276 rapidly-manufactured CAR-T"
] | [
"CD276",
"Chimeric antigen receptor",
"Dash CAR-T",
"Pancreatic cancer",
"Rapidly-manufactured CAR-T"
] | 0 | 10.1186/s12967-024-05462-7
10.1016/S0140-6736(20)30974-0
10.3390/biomedicines11061611
10.3748/wjg.v27.i35.5851
10.1080/00365521.2022.2067786
10.3390/cancers13184724
10.1080/08941939.2022.2129884
10.3390/ijms22168996
10.1186/s12943-022-01663-0
10.3389/fimmu.2023.1113882
10.1002/jha2.356
10.3389/fimmu.2023.1045024
10.3390/cancers14205108
10.1186/s12967-023-04292-3
10.1016/j.phrs.2021.106036
10.1158/2643-3230.BCD-21-0084
10.1056/NEJMoa1709919
10.1056/NEJMoa1709866
10.1038/s41408-022-00694-6
10.1158/1535-7163.MCT-16-0761
10.3389/fonc.2021.654684
10.3389/fimmu.2021.701006
10.1038/85339
10.2147/IJGM.S395553
10.3390/jcm7070172
10.1038/sj.bjc.6605375
10.1158/1078-0432.CCR-18-0432
10.1186/s12885-023-10575-1
10.1016/j.lfs.2023.122024
10.3389/fbioe.2022.886637
10.1038/mt.2016.63
10.1155/2017/8045161
10.1186/s12967-022-03833-6
10.1038/s41551-021-00842-6
10.1158/2326-6066.CIR-17-0405
10.1038/s41591-018-0010-1
10.1038/nm.2446
10.1182/blood-2015-11-683847
10.1158/2159-8290.CD-22-1276 | [
"Deng",
"Deng",
"Tsao",
"Xiong",
"Yao",
"Liu",
"Gu",
"Huang",
"Wang"
] | [
"Department of Research and Development, Hrain Biotechnology Co., Ltd., 1238 Zhangjiang Road, Pudong New District, Shanghai, China.",
"Department of Research and Development, Hrain Biotechnology Co., Ltd., 1238 Zhangjiang Road, Pudong New District, Shanghai, China.",
"Department of Research and Development, Hrain Biotechnology Co., Ltd., 1238 Zhangjiang Road, Pudong New District, Shanghai, China.",
"Department of Research and Development, Hrain Biotechnology Co., Ltd., 1238 Zhangjiang Road, Pudong New District, Shanghai, China.",
"Department of Research and Development, Hrain Biotechnology Co., Ltd., 1238 Zhangjiang Road, Pudong New District, Shanghai, China.",
"Regulatory Affairs Department, Hrain Biotechnology Co., Ltd., 1238 Zhangjiang Road, Pudong New District, Shanghai, China.",
"Department of Research and Development, Hrain Biotechnology Co., Ltd., 1238 Zhangjiang Road, Pudong New District, Shanghai, China.",
"Department of Research and Development, Hrain Biotechnology Co., Ltd., 1238 Zhangjiang Road, Pudong New District, Shanghai, China. [email protected].",
"Department of Research and Development, Hrain Biotechnology Co., Ltd., 1238 Zhangjiang Road, Pudong New District, Shanghai, China. [email protected]."
] | [
"38978106",
"32593337",
"37371705",
"34629806",
"35477331",
"34572951",
"36191926",
"34445701",
"36209106",
"37020537",
"35844304",
"36761757",
"36291891",
"37420216",
"34920118",
"34568831",
"29385376",
"29385370",
"35798714",
"28679835",
"33842369",
"34349762",
"11224528",
"21127709",
"28399408",
"30753824",
"36756390",
"29996538",
"19844235",
"30655315",
"36717836",
"37574043",
"35845425",
"27019998",
"28555090",
"36536403",
"35190680",
"30030295",
"29713085",
"21926977",
"27226436",
"37249512"
] | [] | 9.661609 | 5.483779 |
38975609 | 751 | Nursing care for chimeric antigen receptor T cell therapy survivors: A literature review. | Chimeric antigen receptor T cell (CAR-T) therapy is an immunotherapy that involves genetically modifying the patient's own T cells to express a chimeric antigen receptor, enabling them to recognize and destroy cancer cells. This treatment has revolutionized the prognosis and management of hematological malignancies, leading to a significant increase in long-term survivors. However, there is limited evidence regarding late sequelae and post-treatment care due to the recent emergence of this therapy. The rapid advancement of CAR-T therapies has created opportunities for advanced practice nurses to play a crucial role in coordinating care, providing education, and ensuring the ongoing well-being of survivors. This article provides an overview of the physical, psychosocial, and financial challenges faced by long-term survivors of CAR-T therapy and proposes a comprehensive nursing care plan to address these issues. | [
0.028793247416615486,
-0.0032082702964544296,
0.042937301099300385,
0.06744884699583054,
-0.01682613044977188,
-0.023717746138572693,
0.005430305376648903,
-0.0008727276581339538,
0.008773882873356342,
0.03521580249071121,
0.007998124696314335,
-0.02638779766857624,
-0.037380706518888474,
-0.004080246202647686,
0.002208504592999816,
-0.010926760733127594,
0.022130148485302925,
-0.01930374465882778,
0.04476544260978699,
0.01241212710738182,
0.015563268214464188,
0.0011147762415930629,
0.01801682822406292,
-0.02422289177775383,
-0.040748339146375656,
0.01724708266556263,
0.0016868225065991282,
0.011395824141800404,
-0.03988237679004669,
-0.023248683661222458,
0.0036051697097718716,
-0.01722302846610546,
-0.0444527342915535,
-0.021757304668426514,
0.014408651739358902,
0.04320190101861954,
0.023248683661222458,
0.017126811668276787,
-0.02151675894856453,
-0.029322447255253792,
0.020085515454411507,
0.04050779342651367,
0.0028098674956709146,
0.10728311538696289,
-0.04935985431075096,
-0.005700918845832348,
-0.008202588185667992,
-0.02732592262327671,
-0.0006430823123082519,
0.0006370686460286379,
-0.0372844897210598,
0.014925823546946049,
-0.04873443767428398,
0.04284108057618141,
-0.04411597177386284,
0.042913246899843216,
-0.015442995354533195,
0.02595481649041176,
0.0037615238688886166,
0.00405619153752923,
0.005773082375526428,
-0.0070960805751383305,
-0.0029977932572364807,
-0.016320984810590744,
-0.06364823132753372,
0.0012996952282264829,
-0.05037014186382294,
-0.004711677320301533,
-0.004762792959809303,
0.022466912865638733,
0.03680339828133583,
0.0025527847465127707,
-0.02015767991542816,
0.001850693835876882,
0.02188960462808609,
0.023777883499860764,
-0.0006423305603675544,
0.03466254845261574,
0.02103566937148571,
-0.0030083172023296356,
0.0282881036400795,
-0.03264196962118149,
0.010385534726083279,
-0.022791648283600807,
-0.004813908599317074,
-0.014156078919768333,
-0.04272080957889557,
-0.054892390966415405,
-0.057394061237573624,
0.011678464710712433,
-0.009754103608429432,
0.04611249640583992,
-0.03071760945022106,
0.03403713181614876,
-0.0021137900184839964,
0.03509553149342537,
-0.008809964172542095,
-0.04327406361699104,
0.04175863042473793,
0.019087253138422966,
0.04409191757440567,
-0.013302143663167953,
-0.020109569653868675,
-0.006175995338708162,
0.06210874393582344,
0.0173072200268507,
-0.06287848949432373,
-0.011967118829488754,
0.024968581274151802,
-0.03074166364967823,
-0.0017183939926326275,
-0.04661763831973076,
0.015418941155076027,
0.0552772618830204,
-0.044019751250743866,
-0.035360127687454224,
-0.0048560043796896935,
-0.014095942489802837,
0.013626880012452602,
0.03276224061846733,
-0.03235331550240517,
0.016525447368621826,
0.056287553161382675,
-0.017114784568548203,
-0.007919947616755962,
-0.027758903801441193,
0.05441129952669144,
-0.027831068262457848,
-0.014540950767695904,
-0.04859010875225067,
0.0017830405849963427,
0.006518772337585688,
0.006735262926667929,
-0.03281035274267197,
-0.059270311146974564,
-0.0072825029492378235,
-0.021456623449921608,
-0.028817303478717804,
-0.04796469211578369,
-0.0265321247279644,
0.026051033288240433,
-0.011443933472037315,
-0.014721360057592392,
-0.0032052635215222836,
-0.005234862677752972,
-0.04748360067605972,
0.03155951574444771,
0.030332736670970917,
-0.0021588923409581184,
0.036851510405540466,
-0.029009738937020302,
0.055229153484106064,
0.05609511584043503,
0.024571681395173073,
0.016128549352288246,
-0.04257648065686226,
-0.023320848122239113,
0.027831068262457848,
-0.034253623336553574,
-0.08144856989383698,
-0.003671319456771016,
-0.014348515309393406,
-0.039377231150865555,
-0.016573557630181313,
0.015731649473309517,
-0.025569943711161613,
-0.010728311724960804,
0.034710656851530075,
-0.041518084704875946,
-0.018485890701413155,
-0.029755428433418274,
-0.04592005908489227,
-0.07918744534254074,
-0.012809026055037975,
-0.03879992291331291,
-0.000016185114873223938,
0.013025516644120216,
0.013109708204865456,
-0.018666299059987068,
-0.01559934951364994,
-0.003923892043530941,
0.016970457509160042,
0.01992916129529476,
-0.025497781112790108,
-0.05359344929456711,
0.029226228594779968,
-0.03851126879453659,
0.017090728506445885,
-0.041830793023109436,
-0.025088854134082794,
0.02328476496040821,
-0.010445671156048775,
0.05142854154109955,
-0.005078508518636227,
0.00207470147870481,
-0.0027993435505777597,
0.038126397877931595,
0.017415465787053108,
-0.02720564976334572,
0.005192767363041639,
0.024030454456806183,
-0.013771207071840763,
-0.027879176661372185,
-0.004444070626050234,
0.002423491794615984,
-0.040146976709365845,
-0.016669774428009987,
0.03793396055698395,
0.006933712400496006,
-0.019532261416316032,
0.039353176951408386,
-0.007925961166620255,
-0.013422416523098946,
0.03343576937913895,
-0.027109432965517044,
-0.017295192927122116,
-0.0064826905727386475,
0.02823999524116516,
0.04005075991153717,
0.00936321821063757,
-0.007577170617878437,
-0.014685277827084064,
-0.005839232355356216,
0.035504456609487534,
-0.03360414877533913,
-0.002246089745312929,
0.012177595868706703,
-0.016405176371335983,
0.0064826905727386475,
-0.035167694091796875,
-0.039064522832632065,
-0.0009291054448112845,
0.023838018998503685,
-0.029081901535391808,
-0.043225955218076706,
-0.027061322703957558,
-0.008262723684310913,
0.02128824032843113,
0.06100223585963249,
0.0010411092080175877,
0.02561805211007595,
0.020314034074544907,
0.02576237916946411,
-0.026916995644569397,
-0.015611376613378525,
-0.008503269404172897,
-0.02749430388212204,
-0.0804382786154747,
0.04565545916557312,
-0.00244453945197165,
-0.004101294092833996,
0.028167830780148506,
0.005400237627327442,
-0.015046095475554466,
0.03807828947901726,
0.014396623708307743,
0.034999310970306396,
-0.030501117929816246,
0.022875837981700897,
-0.03213682398200035,
0.021673113107681274,
-0.024150727316737175,
-0.05157287046313286,
-0.056768644601106644,
-0.037188272923231125,
0.02701321430504322,
0.0034909106325358152,
0.0037254421040415764,
0.030332736670970917,
0.0035720947198569775,
0.03572094812989235,
0.02314043790102005,
0.0534491203725338,
0.002088232198730111,
-0.06100223585963249,
0.04483760520815849,
0.017595874145627022,
0.021504731848835945,
0.034830931574106216,
0.002832418540492654,
-0.0036382446996867657,
0.014023778960108757,
0.0010824529454112053,
-0.039377231150865555,
-0.02811972238123417,
-0.020374169573187828,
0.009639845229685307,
-0.01602030359208584,
0.004383934196084738,
-0.021192023530602455,
-0.01428837887942791,
-0.0024791178293526173,
-0.0026294586714357138,
-0.01682613044977188,
-0.02026592381298542,
-0.004236600361764431,
0.011353728361427784,
-0.02018173411488533,
-0.02701321430504322,
0.01912333443760872,
-0.06821858882904053,
0.03788585215806961,
-0.042456209659576416,
-0.02609914354979992,
0.029226228594779968,
0.007180271204560995,
-0.020999586209654808,
-0.027133487164974213,
0.029707320034503937,
0.04442868009209633,
0.01169650536030531,
-0.03276224061846733,
0.04599222168326378,
0.029154065996408463,
-0.008912195451557636,
0.021444596350193024,
0.015406913124024868,
-0.05826002359390259,
0.01980888843536377,
-0.057538386434316635,
-0.030621390789747238,
-0.0058723073452711105,
-0.019856998696923256,
0.008563405834138393,
0.00789589248597622,
-0.024319108575582504,
0.009856335818767548,
-0.0006066246423870325,
0.023489229381084442,
-0.027109432965517044,
0.0019619460217654705,
-0.06990240514278412,
0.05898165702819824,
-0.01764398254454136,
-0.0009945036144927144,
-0.0008719759644009173,
-0.012772944755852222,
-0.04911930859088898,
0.06071358174085617,
-0.03588932752609253,
0.0060046068392694,
0.014372569508850574,
-0.06162765249609947,
0.06889211386442184,
-0.01656153053045273,
-0.01795669086277485,
-0.0016026317607611418,
0.01935185305774212,
-0.010848583653569221,
0.04098888486623764,
0.013711070641875267,
0.027061322703957558,
0.03930506855249405,
0.028937574476003647,
0.002473104279488325,
0.05094745010137558,
-0.030837882310152054,
-0.0113417012616992,
0.0040020691230893135,
-0.022647321224212646,
-0.003436787985265255,
-0.007462911773473024,
-0.035624727606773376,
0.05176530405879021,
0.03928101435303688,
0.07331814616918564,
-0.028793247416615486,
0.05311235785484314,
-0.04616060480475426,
-0.04414002597332001,
-0.01861819066107273,
-0.04808496683835983,
0.02703726850450039,
0.032088715583086014,
-0.06037681922316551,
0.026965105906128883,
0.032858461141586304,
0.007835756987333298,
0.0003786706074606627,
-0.019941188395023346,
0.02482425421476364,
-0.015839895233511925,
-0.020506469532847404,
-0.013759179972112179,
0.012568481266498566,
0.06340768933296204,
0.014504869468510151,
-0.024583708494901657,
-0.05340101197361946,
0.03721232712268829,
-0.03401307761669159,
-0.019219553098082542,
0.01117332000285387,
-0.010944802314043045,
0.006777358241379261,
0.08548972755670547,
-0.030789772048592567,
0.07476141303777695,
0.04426029697060585,
-0.01319389883428812,
0.02795134112238884,
-0.017367355525493622,
-0.026026979088783264,
-0.033748477697372437,
0.036731235682964325,
-0.03617798164486885,
0.034397948533296585,
0.007162230089306831,
0.024655872955918312,
-0.019965242594480515,
0.014925823546946049,
-0.0029632148798555136,
0.039834268391132355,
0.01624882221221924,
0.008815977722406387,
-0.042456209659576416,
-0.04130159318447113,
0.05311235785484314,
-0.021071750670671463,
0.05243883281946182,
0.02532939799129963,
-0.022478939965367317,
0.03879992291331291,
-0.03365226089954376,
-0.009182808920741081,
0.016970457509160042,
0.027446195483207703,
0.03355604037642479,
-0.010854597203433514,
-0.018738463521003723,
-0.002435519127175212,
0.05647999048233032,
-0.012664698995649815,
-0.011389810591936111,
0.022731510922312737,
0.026989160105586052,
-0.01761992834508419,
0.0327862985432148,
-0.04067617654800415,
0.03343576937913895,
-0.02703726850450039,
0.012364017777144909,
0.007559129502624273,
-0.017812363803386688,
0.044957879930734634,
-0.02012159675359726,
0.011389810591936111,
0.003978014457970858,
-0.04529464244842529,
-0.015058123506605625,
-0.029394611716270447,
0.012676727026700974,
0.010271275416016579,
-0.008130424655973911,
-0.03230520710349083,
0.0018837688257917762,
0.007523047737777233,
-0.05311235785484314,
0.016345039010047913,
0.02564210817217827,
0.03389280289411545,
-0.04144592210650444,
0.010596011765301228,
-0.018401699140667915,
0.014372569508850574,
0.03523985669016838,
0.012881189584732056,
-0.02345314621925354,
-0.018882790580391884,
-0.013542689383029938,
0.006903644185513258,
0.01265267189592123,
-0.04596816748380661,
-0.00035142136039212346,
-0.009838294237852097,
0.03605771064758301,
-0.0064826905727386475,
0.036394473165273666,
-0.0020972525235265493,
-0.01784844696521759,
-0.017944663763046265,
-0.008232655934989452,
-0.026315633207559586,
0.03401307761669159,
0.0426967553794384,
0.04753171280026436,
-0.007925961166620255,
0.0024956553243100643,
-0.025401562452316284,
0.05041825398802757,
-0.015442995354533195,
0.014697305858135223,
-0.013554716482758522,
-0.010932774282991886,
-0.030861936509609222,
-0.010253234766423702,
-0.010583984665572643,
-0.0014763455837965012,
-0.024920472875237465,
0.01421621534973383,
-0.007715484127402306,
0.039665885269641876,
0.01222570426762104,
0.01838967204093933,
0.03846316039562225,
0.03651474416255951,
0.011756641790270805,
0.11353728920221329,
0.0031060385517776012,
0.05354533717036247,
-0.04190295562148094,
-0.005427298601716757,
0.05142854154109955,
0.001846183673478663,
-0.04197511821985245,
-0.03490309417247772,
-0.04539085924625397,
-0.03341171517968178,
-0.004693636205047369,
-0.002615927951410413,
-0.005123610608279705,
0.019195498898625374,
0.020590661093592644,
0.016513420268893242,
0.02670050598680973,
-0.01861819066107273,
-0.03528796508908272,
0.009140714071691036,
-0.01724708266556263,
-0.006332349497824907,
0.00985032133758068,
-0.016982484608888626,
-0.008791923522949219,
0.0025227167643606663,
-0.03158356994390488,
-0.017668036743998528,
-0.022106094285845757,
0.037789635360240936,
-0.023477202281355858,
-0.01776425540447235,
-0.017211001366376877,
0.00009687578130979091,
0.04146997630596161,
-0.007865824736654758,
0.0070118894800543785,
0.011443933472037315,
-0.00791393406689167,
-0.021047696471214294,
0.013614852912724018,
-0.009681940078735352,
0.023525310680270195,
-0.03523985669016838,
0.009260986000299454,
0.01020512543618679,
0.009868362918496132,
-0.03730854392051697,
-0.02024186961352825,
-0.026147251948714256,
-0.003926898818463087,
-0.02362152934074402,
-0.001649237354286015,
-0.027542414143681526,
-0.006723235361278057,
-0.02778295800089836,
-0.04919147118926048,
0.007889878936111927,
0.010926760733127594,
-0.03882397711277008,
-0.04801280051469803,
0.014468787238001823,
-0.03305089473724365,
0.004392954986542463,
0.008864087052643299,
-0.05291992053389549,
0.04226377233862877,
0.013699043542146683,
-0.0033345564734190702,
0.015888003632426262,
-0.01172657310962677,
0.029394611716270447,
-0.030332736670970917,
-0.015671513974666595,
-0.01383134350180626,
0.04207133874297142,
-0.0016702850116416812,
0.032088715583086014,
-0.034879039973020554,
-0.02078309655189514,
-0.011906982399523258,
0.008232655934989452,
0.06177198141813278,
0.014168106019496918,
0.02855270355939865,
0.017668036743998528,
-0.05075501650571823,
-0.0056558167561888695,
0.01063209306448698,
-0.010048771277070045,
-0.00125985499471426,
0.02320057526230812,
-0.007907920517027378,
-0.0066330311819911,
-0.009273013100028038,
-0.031150590628385544,
-0.029683265835046768,
0.016104495152831078,
0.009976607747375965,
-0.011065074242651463,
0.0060046068392694,
0.025401562452316284,
0.025810489431023598,
0.027422141283750534,
0.005562605336308479,
0.0229119211435318,
0.04984094575047493,
0.011474001221358776,
-0.013181871734559536,
-0.009176795370876789,
0.0029105956200510263,
-0.004209539387375116,
-0.007697443012148142,
-0.004795867949724197,
0.0027767925057560205,
0.007577170617878437,
-0.012460236437618732,
-0.038751814514398575,
-0.008876114152371883,
0.01841372810304165,
-0.001826639287173748,
-0.0020160686690360308,
0.00047432485735043883,
-0.03225709870457649,
-0.027253760024905205,
0.04731522127985954,
-0.02641185186803341,
-0.009020441211760044,
0.033628202974796295,
-0.02811972238123417,
-0.0018957960419356823,
0.00789589248597622,
-0.03511958569288254,
-0.0059715318493545055,
-0.013518634252250195,
-0.024271000176668167,
0.014396623708307743,
-0.008256710134446621,
-0.04161430150270462,
0.00652478588744998,
0.009994648396968842,
-0.008930237032473087,
-0.002424995182082057,
-0.02888946607708931,
0.002434015739709139,
-0.03620203584432602,
-0.00932112243026495,
-0.042768917977809906,
-0.0006100073223933578,
0.024150727316737175,
0.058789223432540894,
0.0835653692483902,
-0.03449416533112526,
0.01776425540447235,
-0.009663899429142475,
0.0036202038172632456,
0.009657885879278183,
0.007643320597708225,
0.0372844897210598,
-0.021131886169314384,
0.013446470722556114,
-0.001323749776929617,
0.05113988742232323,
0.01582786813378334,
-0.004843976814299822,
-0.026676451787352562,
0.005051447078585625,
-0.012592535465955734,
0.012520371936261654,
-0.012953353114426136,
0.0070419576950371265,
0.0014958898536860943,
-0.022166231647133827,
-0.008996387012302876,
-0.040459685027599335,
-0.03523985669016838,
0.02482425421476364,
-0.00576406205072999,
0.011678464710712433,
0.013518634252250195,
0.01676599308848381,
0.006536812987178564,
-0.0075952112674713135,
-0.01670585758984089,
-0.021853521466255188,
-0.024271000176668167,
0.008659623563289642,
0.016092466190457344,
0.01930374465882778,
-0.01312173530459404,
0.005484428256750107,
-0.0157436765730381,
0.033459823578596115,
0.004843976814299822,
0.02951488271355629,
-0.028047557920217514,
0.022250421345233917,
-0.032377369701862335,
-0.0062120771035552025,
-0.030068136751651764,
0.026026979088783264,
0.020795123651623726,
-0.003033875022083521,
-0.020879315212368965,
-0.005370169412344694,
-0.02484830841422081,
-0.014805550687015057,
-0.006651071831583977,
0.0016747952904552221,
0.04317784681916237,
0.008401037193834782,
0.013458497822284698,
0.0007295281975530088,
0.025401562452316284,
-0.01770411990582943,
-0.01876251772046089,
0.0170787014067173,
0.022106094285845757,
-0.007589197717607021,
0.04233593866229057,
-0.024090591818094254,
0.0003561195044312626,
-0.018570082262158394,
-0.040459685027599335,
-0.021420540288090706,
-0.008815977722406387,
0.009772144258022308,
0.023801937699317932,
-0.008016165345907211,
-0.022791648283600807,
-0.012520371936261654,
-0.012472263537347317,
0.011137237772345543,
-0.02937055565416813,
-0.03218493238091469,
0.00846718717366457,
0.004600424785166979,
0.02353733777999878,
0.023008137941360474,
0.031006263568997383,
-0.0006366927991621196,
-0.05017770826816559,
0.01682613044977188,
0.009062536992132664,
0.008292792364954948,
-0.037043944001197815,
0.0039058509282767773,
-0.04134970158338547,
0.007456898223608732,
-0.021071750670671463,
-0.004708670079708099,
-0.010788447223603725,
-0.011828805319964886,
-0.0015116756549105048,
0.007426830008625984,
0.000804322655312717,
0.015130287036299706,
0.004143389407545328,
0.04454895108938217,
0.032233044505119324,
-0.01830548234283924,
0.000555132981389761,
-0.02518507093191147,
-0.041542138904333115,
0.0013711070641875267,
-0.022948002442717552,
-0.03391685709357262,
0.013759179972112179,
-0.023068275302648544,
0.010193098336458206,
0.0006171485292725265,
0.003911864478141069,
-0.021985821425914764,
0.008828004822134972,
0.005938457325100899,
0.033940915018320084,
-0.00839502364397049,
-0.006175995338708162,
0.0041884914971888065,
0.024126673117280006,
-0.02951488271355629,
-0.005770075600594282,
-0.029995974153280258,
0.014192161150276661,
0.008485228754580021,
-0.0001094668114092201,
-0.0015154341235756874,
0.028143776580691338,
0.04115726798772812,
-0.043538663536310196,
-0.006290254183113575,
-0.0025167029816657305,
-0.012448208406567574,
-0.0014793523587286472,
0.0146010871976614,
-0.041542138904333115,
-0.03071760945022106,
0.0211198590695858,
-0.015503131784498692,
0.028023503720760345,
-0.005454360041767359,
0.011407851241528988,
-0.005694905295968056,
0.013987697660923004,
-0.01024722121655941,
-0.0140478340908885,
-0.05445941165089607,
-0.022310558706521988,
0.012628617696464062,
0.0014831108273938298,
-0.014781496487557888,
-0.014348515309393406,
0.07047971338033676,
-0.00268658809363842,
-0.0015800805995240808,
0.00203861971385777,
-0.014589060097932816,
-0.03204060718417168,
-0.019436044618487358,
0.015430968254804611,
0.00939328595995903,
-0.012135500088334084,
0.028769193217158318,
0.020566605031490326,
-0.026916995644569397,
0.01938793435692787,
-0.03622609004378319,
-0.00705999881029129,
-0.0028910513501614332,
0.006296267732977867,
0.033748477697372437,
0.03396496921777725,
0.01693437434732914,
-0.018918871879577637,
-0.011155279353260994,
-0.024487491697072983,
0.003881796495988965,
0.01961645297706127,
-0.00607677036896348,
0.021396486088633537,
-0.0014823591336607933,
-0.038559380918741226,
-0.007402775343507528,
0.0005780599312856793,
-0.011510082520544529,
-0.010126948356628418,
0.042937301099300385,
0.03430173173546791,
0.021360404789447784,
0.0014575530076399446,
0.03973805159330368,
0.032858461141586304,
-0.018149128183722496,
-0.018401699140667915,
-0.010764393024146557,
-0.0571054071187973,
0.005126617383211851,
-0.03396496921777725,
0.006614990066736937,
-0.016465311869978905,
-0.024066537618637085,
-0.04130159318447113,
0.02132432349026203,
-0.004197511821985245,
0.0030233513098210096,
-0.011546164751052856,
0.007276489399373531,
0.01591205783188343,
-0.016116522252559662,
-0.0016056385356932878,
-0.025690216571092606,
-0.020374169573187828,
0.014985959976911545,
-0.029274338856339455,
-0.03882397711277008,
-0.0033495905809104443,
0.023838018998503685,
0.025401562452316284,
-0.018040882423520088,
-0.00413436908274889,
-0.0032233044039458036,
0.005884334444999695,
-0.008677664212882519,
0.011816778220236301,
-0.015575295314192772,
-0.027927285060286522,
0.009411326609551907,
-0.0038276738487184048,
-0.017884528264403343,
0.030092190951108932,
-0.030188409611582756,
0.013229980133473873,
-0.03971399739384651,
-0.032521698623895645,
-0.028841357678174973,
0.031463298946619034,
0.007222366519272327,
0.009044495411217213,
-0.01924360729753971,
0.039184797555208206,
-0.031920336186885834,
0.04671385884284973,
-0.03480687737464905,
-0.007342638913542032,
0.011534137651324272,
0.020542550832033157,
-0.02180541306734085,
0.021709194406867027,
-0.0026084110140800476,
0.047892529517412186,
0.0044591049663722515,
0.01870238222181797,
-0.008978345431387424,
-0.0010877149179577827,
-0.012111445888876915,
-0.0035901356022804976,
0.010788447223603725,
0.02638779766857624,
0.01319389883428812,
0.03523985669016838,
-0.014300405979156494,
0.018606163561344147,
0.02857675775885582,
-0.0014793523587286472,
0.029611101374030113,
0.013542689383029938,
0.015394886024296284,
0.024210864678025246,
0.01452892366796732,
-0.014937850646674633,
-0.029154065996408463,
0.010271275416016579,
-0.020915396511554718,
0.04130159318447113,
-0.017235055565834045,
-0.023128410801291466,
0.044813551008701324,
0.027879176661372185,
0.009423354640603065,
-0.027398087084293365,
0.011239469982683659,
0.04594411328434944,
0.04625682160258293,
0.003097018226981163,
0.017042620107531548,
0.01233996357768774,
0.0004886072129011154,
-0.043851371854543686,
0.01020512543618679,
-0.028360266238451004,
0.0760122537612915,
-0.04127753898501396,
-0.011678464710712433,
0.012033268809318542,
0.0015500125009566545,
0.004323798231780529,
-0.001975476508960128,
0.030693555250763893,
0.006657085381448269,
0.004281702917069197,
-0.052871812134981155,
0.00815447885543108,
-0.024246945977211,
0.0023783897049725056,
-0.00798609759658575,
0.029875701293349266,
0.03928101435303688,
0.021131886169314384,
0.03312306106090546,
-0.04252837225794792,
0.009303081780672073,
0.009687953628599644,
0.037067998200654984,
0.043394334614276886,
-0.0078117018565535545,
-0.03603365644812584,
-0.035624727606773376,
-0.002405450912192464,
-0.011437918990850449,
-0.019063198938965797,
-0.02530534379184246,
-0.006705194711685181,
0.05282370373606682,
0.027686741203069687,
-0.024271000176668167,
-0.008346915245056152,
-0.005974539089947939,
-0.02416275441646576,
-0.03555256500840187,
-0.03523985669016838,
0.038583435118198395,
0.06461041420698166,
-0.015118259005248547,
-0.0043418388813734055,
0.01258050836622715,
-0.008960304781794548,
-0.04050779342651367,
0.02365761063992977,
0.016525447368621826,
0.000012250417057657614,
0.04033941403031349,
-0.029947863891720772,
0.02288786694407463,
0.012845108285546303,
0.004690629430115223,
0.02182946726679802,
0.006747290026396513,
-0.026508070528507233,
0.0055986871011555195,
-0.04546302184462547,
-0.032858461141586304,
-0.020626742392778397,
-0.03014030121266842,
-0.014480815269052982,
-0.0013290116330608726,
0.023669637739658356,
0.021252159029245377,
-0.01878657191991806,
0.0033856723457574844,
-0.016405176371335983,
0.014661223627626896,
0.01816115528345108,
0.014793523587286472,
0.0267245601862669,
0.002624948276206851,
-0.01653747633099556,
-0.012111445888876915,
0.002857976360246539,
0.009405313059687614,
0.034373894333839417,
-0.001119286403991282,
0.01761992834508419,
-0.06759317219257355,
-0.0018206257373094559,
0.0140478340908885,
0.03490309417247772,
-0.015250558964908123,
-0.012760917656123638,
-0.01579178497195244,
-0.014565005898475647,
0.016729911789298058,
0.03403713181614876,
0.0068856035359203815,
0.03244953230023384,
0.007120134774595499,
0.021312296390533447,
0.030813826248049736,
-0.009357204660773277,
-0.0019829936791211367,
-0.03329144045710564,
0.013157816603779793,
-0.0002597135317046195,
-0.028384322300553322,
0.03355604037642479,
-0.004582384135574102,
-0.012231717817485332,
-0.03413334861397743,
0.006566881202161312,
0.010072826407849789,
0.024030454456806183,
0.015298668295145035,
-0.02461979165673256,
-0.002044633263722062,
-0.0046154591254889965,
-0.020963504910469055,
0.014997987076640129,
-0.0014124508015811443,
-0.0032082702964544296,
0.0001009161860565655,
0.00943538174033165,
-0.004660561215132475,
-0.008527323603630066,
-0.004350859671831131,
0.03011624701321125,
0.03319522365927696,
-0.02501668967306614,
0.0018055916298180819,
-0.021649058908224106,
-0.002933146897703409,
-0.012171582318842411,
0.0016612645704299212,
-0.017295192927122116,
-0.003923892043530941,
0.01000667642802,
-0.03432578593492508,
0.03247358649969101,
0.010271275416016579,
0.010547902435064316,
-0.0016883258940652013,
0.011329674161970615,
0.028047557920217514,
0.0010426127118989825,
-0.004350859671831131,
0.02035011537373066,
-0.03259386122226715,
-0.02320057526230812,
-0.051476649940013885,
0.03540823981165886,
-0.018966980278491974,
-0.04161430150270462,
0.015370831824839115,
-0.02097553201019764,
-0.00861151423305273,
0.012177595868706703,
-0.006554854102432728,
-0.025593997910618782,
-0.0009614286827854812,
0.012255772948265076,
0.017126811668276787,
-0.008148465305566788,
0.03273818641901016,
-0.004176464397460222,
-0.027446195483207703,
-0.03273818641901016,
0.009236931800842285,
0.007667374797165394,
-0.004840970039367676,
-0.004290723241865635,
0.0007663616561330855,
0.038559380918741226,
0.002652009716257453,
-0.00986234936863184,
0.016357066109776497,
0.011642382480204105,
-0.006188022438436747,
-0.0017063667764887214,
-0.019712671637535095,
0.007180271204560995,
-0.005541557911783457,
-0.02362152934074402,
0.015479076653718948,
0.020771069452166557,
0.014781496487557888,
0.02564210817217827,
-0.0019499186892062426,
-0.013350252993404865,
-0.018918871879577637,
-0.004636506550014019,
-0.008178533054888248,
0.056768644601106644,
-0.010589998215436935,
-0.05200584977865219,
0.03509553149342537,
-0.0010892183054238558,
-0.007992111146450043,
-0.0008351425058208406,
0.004492179490625858,
0.0011576232500374317,
-0.0015620397171005607,
-0.02143256738781929,
0.020458361133933067,
0.015190422534942627,
-0.02374180033802986,
0.024258973076939583,
0.030669499188661575,
-0.02857675775885582,
-0.0068856035359203815,
-0.014023778960108757,
0.00045064621372148395,
0.03343576937913895,
0.010577971115708351,
-0.014709332957863808,
0.01226780004799366,
-0.007505007088184357,
0.014107969589531422,
0.027374032884836197,
0.014913796447217464,
-0.008569419384002686,
0.04926363751292229,
0.000011169842764502391,
-0.013927561230957508,
-0.028143776580691338,
-0.02715754136443138,
0.00620606355369091,
-0.006512758322060108,
-0.012760917656123638,
-0.035360127687454224,
0.0053370944224298,
-0.015310695394873619,
0.0072825029492378235,
-0.021985821425914764,
0.0041283550672233105,
-0.030092190951108932,
-0.047459546476602554,
-0.029587047174572945,
-0.02151675894856453,
-0.005481421481817961,
-0.008280765265226364,
0.009182808920741081,
0.002086728811264038,
-0.03127086162567139,
0.01884670928120613,
-0.005848252680152655,
0.004952222108840942,
0.01668180339038372,
-0.010481752455234528,
-0.0013463008217513561,
0.010620065964758396,
0.018233317881822586,
0.014540950767695904,
-0.0025212133768945932,
-0.06932509690523148,
0.005009351763874292,
-0.04103699326515198,
-0.014817577786743641,
-0.009501531720161438,
0.0020972525235265493,
-0.025401562452316284,
-0.019712671637535095,
-0.0023964305873960257,
0.012496317736804485,
-0.009922484867274761,
-0.0029737388249486685,
0.000764106516726315,
0.011762655340135098,
0.015178395435214043,
0.00882199127227068,
-0.026916995644569397,
0.00841306522488594,
-0.010463711805641651,
-0.0025362474843859673,
0.023789910599589348,
0.012760917656123638,
-0.01312173530459404,
-0.0009644355159252882,
0.01608043909072876,
0.028985684737563133,
-0.007950015366077423,
-0.0012530896347016096,
-0.003256379161030054,
0.00882199127227068,
0.044332463294267654,
0.0224909670650959,
0.0029812557622790337,
-0.01755979284644127,
-0.011137237772345543,
-0.008178533054888248,
0.03312306106090546,
0.031318970024585724,
0.04036346822977066,
0.016272876411676407,
-0.0282881036400795,
-0.03697178140282631,
-0.014492842368781567,
0.002620438113808632,
-0.016778020188212395,
0.01693437434732914,
0.006861548870801926,
0.022707456722855568,
-0.017006538808345795,
-0.027879176661372185,
-0.017198974266648293,
0.013699043542146683,
-0.004964249674230814,
-0.0034127335529774427,
0.007150202989578247,
-0.03526391088962555,
-0.0027993435505777597,
0.006627017632126808,
0.01849791780114174,
-0.0020010345615446568,
0.03759719803929329,
-0.015058123506605625,
0.020338088274002075,
-0.007661361247301102,
0.048493891954422,
0.015346777625381947,
0.014961904846131802,
-0.0009914968395605683,
-0.018028855323791504,
0.004678602330386639,
0.00368635356426239,
-0.02886541187763214,
0.02530534379184246,
0.021167969331145287,
-0.013374307192862034,
-0.0051687126979231834,
0.030188409611582756,
-0.0013245014706626534,
-0.03692367300391197,
-0.007721497677266598,
-0.014925823546946049,
0.015442995354533195,
-0.014312433078885078,
0.008527323603630066,
0.015551240183413029,
-0.032208990305662155,
-0.008996387012302876,
-0.0027392073534429073,
-0.023813964799046516,
-0.014444733038544655,
0.014769469387829304,
0.0017469588201493025,
0.003060936462134123,
-0.025257235392928123,
-0.041229430586099625,
-0.0629747062921524,
0.020458361133933067,
-0.003259386168792844,
-0.035624727606773376,
-0.007679402362555265,
-0.023609502241015434,
0.03447011113166809,
0.030308682471513748,
-0.04070023074746132,
0.011329674161970615,
0.052102066576480865,
0.04312973469495773,
0.010385534726083279,
0.010096880607306957,
0.015346777625381947,
0.007523047737777233,
-0.008846046403050423,
0.011979145929217339,
-0.01436054240912199,
-0.004904113244265318,
0.026748614385724068,
-0.028817303478717804,
0.011900968849658966,
0.021769331768155098,
0.0035089515149593353,
-0.0002277661405969411,
0.004549309145659208,
-0.034518223255872726,
0.042600538581609726,
-0.014685277827084064,
-0.005640782415866852,
-0.02385004609823227,
-0.02049444243311882,
-0.005535543896257877,
-0.012917271815240383,
0.013530661351978779,
-0.020734988152980804,
-0.010926760733127594,
0.008190560154616833,
0.036418527364730835,
-0.034109294414520264,
-0.029683265835046768,
0.00031872224644757807,
0.025281289592385292,
0.015984222292900085,
-0.006897630635648966,
0.0012275316985324025,
-0.0054693943820893764,
-0.02041025087237358,
0.008659623563289642,
-0.0011057558003813028,
-0.018269401043653488,
0.0025257235392928123,
-0.031751953065395355,
-0.004901106469333172,
0.00839502364397049,
-0.0017093735514208674,
0.014949877746403217,
0.00683749420568347,
-0.013566743582487106,
-0.006975807715207338,
-0.03158356994390488,
0.0012147527886554599,
-0.033459823578596115,
-0.017920609563589096,
-0.012845108285546303,
0.007925961166620255,
0.004747759085148573,
0.001628189580515027,
-0.025858597829937935,
-0.0011741607449948788,
-0.01964050717651844,
-0.016008276492357254,
-0.015430968254804611,
-0.006100825034081936,
-0.013879451900720596,
0.0159721951931715,
-0.027446195483207703,
-0.0025317370891571045,
-0.019941188395023346,
-0.024547627195715904,
-0.003047405742108822,
0.017716147005558014,
-0.03615392744541168,
0.016573557630181313,
-0.011756641790270805,
-0.008286778815090656,
0.005033405963331461,
0.0197848342359066,
-0.015611376613378525,
0.00015428713231813163,
-0.05378588289022446,
0.009585722349584103,
0.0033586109057068825,
0.02766268700361252,
0.016874238848686218,
-0.007084053009748459,
0.005069487728178501,
0.01020512543618679,
-0.021456623449921608,
-0.036851510405540466,
-0.04375515505671501,
0.008864087052643299,
-0.018798599019646645,
-0.013422416523098946,
-0.001644727075472474,
-0.007661361247301102,
-0.012544427067041397,
0.01947212591767311,
-0.05243883281946182,
-0.021901631727814674,
-0.03088599070906639,
0.005956497974693775,
0.002673057373613119,
0.04358677193522453,
-0.023104356601834297,
-0.0013320185244083405,
-0.004843976814299822,
0.022154202684760094,
-0.041710518300533295,
0.006500731222331524,
0.02624347060918808,
0.003084990894421935,
-0.03163168206810951,
0.0327862985432148,
0.011979145929217339,
-0.04127753898501396,
0.014348515309393406,
-0.017006538808345795,
0.0035450332798063755,
0.007907920517027378,
-0.0327862985432148,
-0.0017845439724624157,
-0.009531599469482899,
0.011864886619150639,
0.011107170023024082,
0.009669912979006767,
-0.027710795402526855,
0.008070288226008415,
-0.024090591818094254,
-0.01084257010370493,
0.00570693239569664,
-0.003511958522722125,
-0.030789772048592567,
0.031439244747161865,
0.009327135980129242,
0.0197848342359066,
0.031102480366826057,
0.0007306557381525636,
-0.014613114297389984,
-0.007186284754425287,
-0.02595481649041176,
-0.01818520948290825,
0.022695429623126984,
-0.010451684705913067,
0.017379382625222206,
0.025810489431023598,
0.015924084931612015,
-0.004462111741304398,
0.03815045207738876,
0.00702391704544425,
-0.005721966736018658,
-0.010577971115708351,
0.009489503689110279,
0.006380458828061819,
-0.022875837981700897,
0.006464649457484484,
0.1337430775165558,
-0.007210339419543743,
-0.0033916858956217766,
0.00822664238512516,
0.0008020675741136074,
-0.021649058908224106,
-0.004994317423552275,
0.0011741607449948788,
0.0007235145312733948,
-0.007817715406417847,
0.025425616651773453,
0.009976607747375965,
0.0363704189658165,
0.003857742063701153,
0.03620203584432602,
-0.014083915390074253,
-0.0001912145671667531,
0.05888544023036957,
-0.005027392413467169,
-0.00569189852103591,
0.006188022438436747,
0.008052247576415539,
-0.0021498717833310366,
0.002683581318706274,
-0.024631818756461143,
-0.007721497677266598,
0.0027993435505777597,
0.011107170023024082,
-0.007571157068014145,
-0.01861819066107273,
-0.0010516331531107426,
0.02484830841422081,
0.01591205783188343,
0.0037344626616686583,
-0.0267245601862669,
-0.041061047464609146,
-0.004167443607002497,
-0.006332349497824907,
0.01628490351140499,
-0.0023558386601507664,
-0.007901906035840511,
0.00483796326443553,
-0.011431905440986156,
0.01411999762058258,
0.025064799934625626,
-0.019508207216858864,
-0.037669360637664795,
-0.007276489399373531,
0.0025813495740294456,
-0.0251610167324543,
-0.0012545930221676826,
-0.011606301181018353,
0.009375245310366154,
-0.0035480402875691652,
-0.037645306438207626,
-0.031006263568997383,
0.012544427067041397,
0.01063209306448698,
-0.004125348292291164,
-0.023717746138572693,
-0.03180006146430969,
0.009970594197511673,
0.006446608807891607,
-0.00008677476580487564,
0.010854597203433514
] | 2024-07-08 | 29 | 38975609 | [
"post-treatment care",
"care",
"advanced practice nurses",
"cancer cells",
"hematological malignancies",
"survivors",
"limited evidence",
"CAR-T therapies",
"Chimeric antigen receptor T cell (CAR-T) therapy",
"a comprehensive nursing care plan",
"CAR-T therapy",
"long-term survivors",
"management",
"a chimeric antigen receptor",
"education",
"opportunities",
"the patients own T cells",
"this therapy",
"a significant increase",
"a crucial role",
"the recent emergence",
"the ongoing well-being",
"The rapid advancement",
"the physical, psychosocial, and financial challenges",
"the prognosis",
"an overview",
"an immunotherapy",
"This treatment",
"these issues",
"This article"
] | [
"Advance practice nursing",
"CAR T-cell therapy",
"Cancer care",
"Cancer survivors",
"Nurse's role",
"Nurses' practice patterns"
] | 0 | 10.1016/j.apjon.2024.100495
10.35667/MetasEnf.2019.23.1003081564
10.1038/s41409-021-01463-y
10.1016/S1470-2045(23)00222-X
10.1188/21.CJON.255-258
10.1007/s44228-022-00004-8
10.1016/j.annonc.2021.12.003
10.1136/esmoopen-2020-000746
10.1200/JCO.20.01467
10.1016/j.bbmt.2018.11.025
10.1016/j.bbmt.2019.08.003
10.1007/s15010-020-01521-5
10.1016/j.bbmt.2019.09.037
10.1188/19.CJON.S1.42-48
10.3390/curroncol30050378
10.1016/j.jtct.2020.10.002
10.1016/j.jtct.2021.01.003
10.1002/cncr.34557
10.1016/j.jtct.2021.07.007
10.1016/j.jtct.2023.01.004
10.1002/cncr.34557
10.1111/jan.14962
10.1634/theoncologist.2019-0184
10.1007/s13187-018-1457-y
10.1097/NCC.0000000000000704
10.4045/tidsskr.13.1145
10.1093/jnci/85.5.365
10.6004/jadpro.2019.10.4.12 | [
"Montoro-Lorite",
"Moreno",
"Ramos",
"Solano",
"Lahoz",
"Bonilla-Serrano",
"Domènech",
"Ayora"
] | [
"Institute of Cancer and Blood Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.",
"Institute of Cancer and Blood Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.",
"Institute of Cancer and Blood Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.",
"Institute of Cancer and Blood Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.",
"Institute of Cancer and Blood Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.",
"Institute of Cancer and Blood Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.",
"Institute of Cancer and Blood Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.",
"Institute of Cancer and Blood Diseases, Hospital Clínic de Barcelona, Barcelona, Spain."
] | [
"38975609",
"35046545",
"37414060",
"34019023",
"36131128",
"34923107",
"32839196",
"33021872",
"30500439",
"31419568",
"32979154",
"31605820",
"30880816",
"37232836",
"33928266",
"33965176",
"36457279",
"34265479",
"36634738",
"36457279",
"34235775",
"32043786",
"30610655",
"30994515",
"19543809",
"28194657",
"24518484",
"8433390",
"33520344"
] | [] | 7.20328 | 4.374543 |
38972512 | 752 | Subsequent Malignancies After CD19-Targeted Chimeric Antigen Receptor T Cells in Patients With Lymphoma. | Chimeric antigen receptor (CAR) T cells are an established treatment for B cell non-Hodgkin lymphomas (B-NHL). With the remarkable success in improving survival, understanding the late effects of CAR T cell therapy is becoming more relevant. The aim of this study is to determine the incidence of subsequent malignancies in adult patients with B-NHL. We retrospectively studied 355 patients from 2 different medical centers treated with four different CAR T cell products from 2016 to 2022. The overall cumulative incidence for subsequent malignancies at 36 months was 14% (95% CI: 9.2%, 19%). Subsequent malignancies were grouped into 3 primary categories: solid tumor, hematologic malignancy, and dermatologic malignancy with cumulative incidences at 36 months of 6.1% (95% CI: 3.1%-10%), 4.5% (95% CI: 2.1%-8.1%) and 4.2% (95% CI: 2.1%-7.5%) respectively. Notably, no cases of T cell malignancies were observed. In univariable analysis, increasing age was associated with higher risk for subsequent malignancy. While the overall benefits of CAR T products continue to outweigh their potential risks, more studies and longer follow ups are needed to further demonstrate the risks, patterns, and molecular pathways that lead to the development of subsequent malignancies. | [
-0.000033269116102019325,
0.03516577556729317,
0.09164130687713623,
0.05785412713885307,
-0.010508841834962368,
-0.021636882796883583,
0.019604044035077095,
0.00606346782296896,
0.02271171659231186,
-0.005648721940815449,
-0.017582887783646584,
-0.044208403676748276,
-0.07056520879268646,
-0.004489185754209757,
0.011285760439932346,
-0.01008241344243288,
0.028740135952830315,
-0.0060868337750434875,
0.006279602646827698,
0.008078781887888908,
0.019568994641304016,
0.012360595166683197,
-0.009270446375012398,
-0.0029908432625234127,
-0.025609096512198448,
-0.015468267723917961,
-0.00020116634550504386,
-0.00044030239223502576,
-0.004381118342280388,
-0.0028521078638732433,
0.004062756896018982,
-0.015818757936358452,
-0.01907830871641636,
0.01704546995460987,
-0.00015379551041405648,
0.05070414021611214,
0.05748027190566063,
-0.007015630602836609,
-0.021765395998954773,
-0.04254942014813423,
0.017162300646305084,
0.02852984145283699,
0.006986423395574093,
0.0665929988026619,
-0.07042501866817474,
-0.013996212743222713,
0.017863279208540916,
-0.04986296594142914,
0.02570256032049656,
0.02537543699145317,
-0.053087469190359116,
-0.030352387577295303,
-0.03579665720462799,
0.04902179166674614,
-0.04390464723110199,
0.043507423251867294,
-0.023085571825504303,
0.002522063674405217,
-0.002110238652676344,
-0.027641935274004936,
0.02386833168566227,
-0.023120621219277382,
0.010000632144510746,
-0.029324283823370934,
-0.04605431482195854,
-0.030632779002189636,
-0.05416230484843254,
-0.01307325717061758,
0.004892248660326004,
0.024207139387726784,
-0.014183140359818935,
-0.027805497869849205,
0.013201769441366196,
-0.014054627157747746,
0.02113451436161995,
0.057340074330568314,
0.007967793382704258,
-0.018540892750024796,
0.0028389645740389824,
0.019417116418480873,
0.023809917271137238,
0.01634449139237404,
-0.009544996544718742,
-0.02194063924252987,
-0.0030930694192647934,
0.011934165842831135,
-0.0016633645864203572,
-0.03918472304940224,
-0.07061194628477097,
0.019498897716403008,
-0.003268314292654395,
0.006484054960310459,
-0.03444143012166023,
0.02170697972178459,
-0.0039225611835718155,
-0.02469782344996929,
-0.010397854261100292,
-0.037549104541540146,
0.04423176869750023,
-0.005762630607932806,
0.031988006085157394,
0.058555103838443756,
0.014697191305458546,
-0.03934828191995621,
0.019966216757893562,
-0.001478627440519631,
-0.06229365989565849,
0.008627882227301598,
0.0026666405610740185,
-0.02570256032049656,
0.03465172275900841,
0.013119989074766636,
-0.03313293680548668,
0.04981623589992523,
-0.05687275528907776,
-0.019790971651673317,
-0.043016739189624786,
-0.013856016099452972,
0.01196337305009365,
0.021438272669911385,
-0.010888539254665375,
0.02486138604581356,
0.033436693251132965,
-0.021601833403110504,
0.03820335119962692,
-0.0009463215246796608,
0.08173414319753647,
-0.013377014547586441,
-0.018832966685295105,
-0.06262078136205673,
0.026543734595179558,
-0.004296416416764259,
0.00997142493724823,
-0.029534578323364258,
-0.08430439978837967,
-0.017734766006469727,
0.003636328037828207,
-0.03110009804368019,
-0.04194190353155136,
-0.017290813848376274,
-0.008750553242862225,
-0.02245469205081463,
-0.003443558933213353,
-0.004544680006802082,
-0.018213769420981407,
-0.004343148320913315,
0.03451152890920639,
0.017407642677426338,
0.036941587924957275,
0.033366598188877106,
-0.06056457757949829,
0.05603158101439476,
0.016297759488224983,
0.025936219841241837,
0.008464320562779903,
-0.03792295977473259,
-0.00830075889825821,
0.05472308769822121,
-0.05313420295715332,
-0.05107799544930458,
-0.011729713529348373,
-0.0031368806958198547,
-0.021800443530082703,
-0.039838969707489014,
0.01306157372891903,
0.0016458401223644614,
-0.007266814820468426,
0.013003159314393997,
-0.05673256143927574,
-0.0053537264466285706,
-0.0062737613916397095,
-0.008365015499293804,
-0.06416293978691101,
-0.06892959028482437,
-0.0614992156624794,
-0.008067099377512932,
0.00625623669475317,
0.01656646840274334,
-0.013622356578707695,
0.007161668036133051,
0.022361228242516518,
0.009083518758416176,
0.03902116045355797,
-0.021625200286507607,
-0.043507423251867294,
0.033016107976436615,
-0.0027265159878879786,
0.015491633675992489,
-0.053087469190359116,
-0.031240293756127357,
0.03878749907016754,
-0.019218504428863525,
0.04750300571322441,
-0.006974740419536829,
0.0028272815980017185,
-0.00922955572605133,
0.013318599201738834,
0.02451089583337307,
-0.025468900799751282,
-0.021753711625933647,
0.03775939717888832,
-0.057620465755462646,
-0.021251343190670013,
0.014580361545085907,
-0.0032712349202483892,
-0.012699401006102562,
-0.01379760168492794,
0.04722261428833008,
0.013038207776844501,
-0.010129145346581936,
0.024884751066565514,
0.014370067976415157,
-0.048227351158857346,
0.03670793026685715,
-0.04075024276971817,
-0.03362362086772919,
-0.02469782344996929,
0.017582887783646584,
0.02248973958194256,
0.014370067976415157,
0.04275971278548241,
-0.0010098477359861135,
-0.020012948662042618,
0.016414590179920197,
-0.010140827856957912,
0.0286233052611351,
0.03049258328974247,
0.0011332492576912045,
0.006630092393606901,
-0.03201137110590935,
-0.03313293680548668,
0.024370700120925903,
0.012652669101953506,
-0.022559838369488716,
-0.052666883915662766,
-0.01688190922141075,
0.029955165460705757,
0.03610041365027428,
0.03364698961377144,
-0.0046060155145823956,
0.00902510341256857,
0.004676113370805979,
0.028763500973582268,
-0.0015304706757888198,
0.012781182304024696,
-0.03145058825612068,
-0.005155115853995085,
-0.05425576865673065,
0.02544553391635418,
-0.016040734946727753,
-0.03677802532911301,
0.030001897364854813,
0.008984212763607502,
0.002526444848626852,
0.014545312151312828,
-0.0031631672754883766,
0.04511967673897743,
-0.03254878893494606,
0.0036713769659399986,
-0.02441743202507496,
0.04254942014813423,
-0.0456804595887661,
-0.04818061739206314,
-0.05219956487417221,
-0.05850837379693985,
0.008861541748046875,
0.010555573739111423,
0.017185665667057037,
0.014042944647371769,
-0.01708051934838295,
0.027431640774011612,
0.008645406924188137,
0.03338996320962906,
-0.02785222977399826,
-0.03691822290420532,
0.022209348157048225,
0.0008097767131403089,
0.023681404069066048,
-0.005435507278889418,
0.0036918222904205322,
-0.00689880084246397,
0.031730979681015015,
-0.010508841834962368,
-0.03411430865526199,
0.0013355108676478267,
-0.026076415553689003,
0.000973338435869664,
0.007366119883954525,
-0.0017977188108488917,
-0.044699087738990784,
-0.0005713708233088255,
-0.0003382588329259306,
-0.011350017040967941,
-0.02836628071963787,
-0.018178720027208328,
0.015035998076200485,
0.025842756032943726,
-0.01974423974752426,
-0.044021476060152054,
0.03878749907016754,
-0.04836754500865936,
0.01894979737699032,
-0.019755922257900238,
-0.029768237844109535,
0.02621661126613617,
0.03621724247932434,
0.008551943115890026,
0.012348911724984646,
0.011846543289721012,
0.049489110708236694,
0.02673066221177578,
-0.01695200614631176,
0.02280518040060997,
0.021473320201039314,
0.009241238236427307,
0.02810925431549549,
0.0005071144551038742,
-0.03876413404941559,
0.026333441957831383,
-0.03775939717888832,
-0.009305494837462902,
0.00021065876353532076,
-0.042572785168886185,
0.03383391723036766,
-0.018424062058329582,
-0.033530157059431076,
-0.002798074157908559,
-0.020994318649172783,
0.017092201858758926,
-0.039932433515787125,
0.01665993221104145,
-0.03409093990921974,
0.04990969970822334,
0.013961163349449635,
0.009393117390573025,
-0.021157879382371902,
-0.0036012791097164154,
-0.037362176924943924,
0.014288286678493023,
0.020024631172418594,
-0.004124092403799295,
0.03469845652580261,
-0.042479321360588074,
0.05327439680695534,
0.024978214874863625,
-0.012325545772910118,
-0.021216295659542084,
0.017360910773277283,
-0.027525104582309723,
-0.02038680389523506,
0.0009375592926517129,
0.002006552182137966,
0.0405866801738739,
0.017828229814767838,
-0.0333198644220829,
0.04434859752655029,
-0.025772657245397568,
-0.009877961128950119,
0.031216926872730255,
0.008359173312783241,
-0.02502494677901268,
0.0006140867481008172,
-0.01662488281726837,
0.07285507768392563,
0.0717802420258522,
0.053087469190359116,
-0.0401427261531353,
0.0632283017039299,
-0.022174298763275146,
-0.019790971651673317,
-0.015935586765408516,
-0.02087748795747757,
0.02827281691133976,
0.02010641247034073,
-0.054629623889923096,
0.03065614402294159,
-0.004471661522984505,
0.005558178760111332,
0.015748659148812294,
0.012465741485357285,
0.021496687084436417,
-0.017033787444233894,
0.00828323420137167,
-0.03553963080048561,
0.005493922159075737,
0.028249450027942657,
-0.01727912947535515,
0.015468267723917961,
-0.06724724173545837,
0.015912221744656563,
-0.038226716220378876,
0.02062046341598034,
0.007453742437064648,
-0.006857910193502903,
-0.046241242438554764,
0.030352387577295303,
-0.020094728097319603,
0.07579918950796127,
0.04091380164027214,
0.008616198785603046,
0.0029382698703557253,
-0.04236249253153801,
-0.0019043260253965855,
-0.04776002839207649,
0.02335428074002266,
-0.016192613169550896,
0.01862267404794693,
0.0018663563532754779,
0.051451850682497025,
-0.017874961718916893,
-0.013236818835139275,
0.013213452883064747,
0.03948847949504852,
-0.011723872274160385,
0.005958320572972298,
-0.005756789352744818,
-0.0418718084692955,
0.05673256143927574,
-0.011501895263791084,
0.048647936433553696,
0.03567982837557793,
-0.04107736423611641,
0.044699087738990784,
-0.022337861359119415,
-0.017314178869128227,
-0.038834232836961746,
0.01579539105296135,
0.012419009581208229,
-0.0015494554536417127,
-0.022723399102687836,
-0.027127884328365326,
0.10196906328201294,
-0.023529525846242905,
-0.012056837789714336,
0.011630408465862274,
0.019405432045459747,
-0.012524156831204891,
0.006863751914352179,
-0.05107799544930458,
0.014335018582642078,
0.008598675020039082,
-0.01199842244386673,
-0.002012393670156598,
-0.004141617100685835,
0.05589138716459274,
-0.02203410305082798,
-0.018891381099820137,
-0.0002756453468464315,
-0.01159536000341177,
-0.021625200286507607,
-0.02612314745783806,
-0.011846543289721012,
-0.003615882946178317,
-0.02373981848359108,
-0.05285381153225899,
-0.0019101675134152174,
0.018155353143811226,
-0.07734134048223495,
-0.013505526818335056,
0.012804548256099224,
0.019510580226778984,
-0.028202718123793602,
0.015573414973914623,
-0.042409222573041916,
-0.014253238216042519,
0.02502494677901268,
0.03479192033410072,
-0.03271234780550003,
0.020865805447101593,
-0.033109571784734726,
0.01891474798321724,
-0.01698705554008484,
-0.007447901181876659,
0.002443203702569008,
0.029487846419215202,
0.06014399230480194,
-0.03836691379547119,
0.023716453462839127,
0.017454374581575394,
-0.03056268021464348,
-0.0019890277180820704,
-0.019674140959978104,
-0.019861068576574326,
0.00788017176091671,
0.03806315362453461,
0.03280581161379814,
0.0031660881359130144,
0.03254878893494606,
-0.0016370778903365135,
0.03960530832409859,
-0.03638080507516861,
-0.00706820422783494,
0.021216295659542084,
-0.009994790889322758,
-0.022688351571559906,
-0.01618093065917492,
0.01640290580689907,
-0.016157563775777817,
-0.002608225680887699,
0.00403647031635046,
0.002777629066258669,
-0.007331070955842733,
0.03268898278474808,
0.00353410211391747,
0.034464795142412186,
0.040703509002923965,
-0.008277392946183681,
0.05089106783270836,
-0.01930028572678566,
0.009130250662565231,
-0.023401012644171715,
-0.013306916691362858,
0.03039911948144436,
-0.01805020682513714,
-0.04409157484769821,
-0.05374171584844589,
-0.045400068163871765,
-0.012781182304024696,
0.004865962080657482,
0.0044161672703921795,
-0.007079887203872204,
-0.020047996193170547,
-0.0029441113583743572,
0.007523840293288231,
0.04039975255727768,
-0.054863281548023224,
-0.013341965153813362,
-0.011122198775410652,
-0.02409030869603157,
-0.020176509395241737,
0.04161478206515312,
0.007038996554911137,
0.007401169277727604,
0.0057801553048193455,
-0.003943006508052349,
-0.002606765367090702,
-0.03411430865526199,
0.01563183031976223,
-0.02187054231762886,
-0.012161984108388424,
-0.0011149946367368102,
0.019861068576574326,
0.026870857924222946,
-0.011706347577273846,
-0.0001250444183824584,
-0.002097095362842083,
0.02306220680475235,
-0.038717400282621384,
0.02326081693172455,
-0.018599307164549828,
0.016963690519332886,
-0.04011936113238335,
0.03257215395569801,
0.02666056528687477,
-0.006735239177942276,
-0.024020209908485413,
-0.0008265709620900452,
-0.017804864794015884,
-0.01050300057977438,
-0.025725925341248512,
0.0035019738133996725,
-0.002209543948993087,
-0.011104674078524113,
-0.009591728448867798,
-0.013353648595511913,
0.01188743393868208,
0.011881592683494091,
-0.0027542628813534975,
-0.028132621198892593,
0.027431640774011612,
-0.022536471486091614,
-0.003960530739277601,
0.01647300459444523,
-0.010567257180809975,
0.03516577556729317,
0.00034556069294922054,
-0.004454136826097965,
0.03238522633910179,
-0.01019340194761753,
0.01570192724466324,
-0.02042185328900814,
-0.025492265820503235,
0.00217887619510293,
0.0435541570186615,
-0.00562243489548564,
0.03939501568675041,
-0.03152068704366684,
-0.008464320562779903,
0.002358502009883523,
-0.010561415925621986,
0.06047111377120018,
-0.0012916997075080872,
0.020047996193170547,
0.010409536771476269,
-0.019919484853744507,
0.017910011112689972,
0.0042847334407269955,
-0.01357562467455864,
-0.022992108017206192,
0.005327439866960049,
0.0066885072737932205,
-0.006238712463527918,
-0.016671614721417427,
-0.03827344998717308,
-0.009060152806341648,
0.058134518563747406,
0.00902510341256857,
-0.002037219936028123,
-0.022267764434218407,
0.03836691379547119,
0.028763500973582268,
0.020667195320129395,
-0.005388775374740362,
0.030632779002189636,
0.054442696273326874,
0.02810925431549549,
-0.034885384142398834,
-0.01636785827577114,
0.011612883768975735,
-0.014054627157747746,
0.007202558219432831,
0.017489423975348473,
-0.0011551547795534134,
0.006221187766641378,
0.01933533512055874,
-0.04089043661952019,
0.00573342340067029,
-0.0065950434654951096,
0.020012948662042618,
0.002703150035813451,
0.011344175785779953,
-0.042152199894189835,
-0.012103569693863392,
0.02666056528687477,
-0.008084623143076897,
-0.0363340750336647,
0.03434796631336212,
0.022396275773644447,
-0.03196463733911514,
-0.003008367959409952,
-0.017933377996087074,
0.00892579834908247,
-0.01570192724466324,
-0.020176509395241737,
0.009089360013604164,
-0.026076415553689003,
-0.016928641125559807,
-0.001594727043993771,
0.00353410211391747,
-0.006910483818501234,
-0.007815915159881115,
-0.028062522411346436,
-0.0007608542218804359,
-0.04289991036057472,
-0.0006199282361194491,
-0.05687275528907776,
0.008984212763607502,
0.010929429903626442,
0.03656773269176483,
0.08187434077262878,
-0.011910799890756607,
0.011326651088893414,
-0.0034114306326955557,
-0.013949480839073658,
-0.01370413787662983,
0.0013647183077409863,
0.04030628874897957,
-0.001526089501567185,
0.015877172350883484,
0.00371518824249506,
0.07542533427476883,
0.018610989674925804,
-0.002136525232344866,
-0.015608463436365128,
0.0003891893429681659,
-0.02222103253006935,
0.0031777711119502783,
-0.00044650895870290697,
-0.01009993813931942,
0.016893591731786728,
0.012629303149878979,
0.003566230181604624,
-0.037198614329099655,
-0.049582574516534805,
0.008610357530415058,
0.00455928361043334,
0.028413012623786926,
0.0032595519442111254,
0.01306157372891903,
-0.0006575328297913074,
-0.014323336072266102,
-0.031193561851978302,
-0.027548471465706825,
0.006495737936347723,
0.02126302756369114,
0.0021277631167322397,
-0.007611462846398354,
-0.029511211439967155,
-0.0469655878841877,
-0.006110199727118015,
0.03303947299718857,
0.0031748502515256405,
0.0657518208026886,
-0.022875279188156128,
0.01444016583263874,
-0.02511841058731079,
-0.01737259328365326,
-0.036684561520814896,
0.00604594312608242,
0.005937875714153051,
0.010946953669190407,
-0.008844017051160336,
-0.020047996193170547,
0.002673942595720291,
-0.02106441557407379,
-0.011490212753415108,
-0.024557627737522125,
0.008318282663822174,
-0.0006929468363523483,
0.01781654730439186,
0.00974360667169094,
0.04110072925686836,
-0.026006318628787994,
-0.008610357530415058,
0.05332113057374954,
0.07958447188138962,
-0.03563309460878372,
0.044114939868450165,
-0.00541214132681489,
-0.026870857924222946,
-0.012056837789714336,
-0.022150933742523193,
-0.011636249721050262,
-0.013201769441366196,
-0.005788917653262615,
0.036521002650260925,
-0.023564575240015984,
-0.013762552291154861,
-0.005225213710218668,
0.012173667550086975,
0.02495484985411167,
-0.02656710147857666,
-0.04827408120036125,
0.003963451832532883,
0.020433535799384117,
0.016379540786147118,
0.030212191864848137,
0.009521630592644215,
-0.013038207776844501,
-0.024323968216776848,
0.030889803543686867,
0.007967793382704258,
-0.011718031018972397,
-0.019148407503962517,
-0.007553047966212034,
-0.035656459629535675,
0.008709662593901157,
0.010789234191179276,
-0.021146196871995926,
-0.021800443530082703,
0.003522419137880206,
0.0034932116977870464,
0.004214635584503412,
0.019475530833005905,
0.020667195320129395,
0.005739264655858278,
0.024207139387726784,
0.03140385448932648,
0.0076523530296981335,
0.0006279602530412376,
-0.01040369551628828,
-0.035072311758995056,
0.034277867525815964,
-0.02673066221177578,
-0.01136754173785448,
0.014755605719983578,
-0.01188743393868208,
0.00727849779650569,
0.011601201258599758,
-0.011601201258599758,
-0.008884907700121403,
-0.007348595652729273,
0.007985318079590797,
0.018984844908118248,
-0.012419009581208229,
0.0012274433393031359,
0.0009514328557997942,
0.02416040748357773,
-0.02810925431549549,
-0.005604910664260387,
-0.02768866717815399,
0.010269341059029102,
-0.019545629620552063,
-0.005972924642264843,
0.00022599268413614482,
0.012652669101953506,
0.02869340404868126,
-0.07645343244075775,
-0.03490874916315079,
-0.014755605719983578,
-0.004795864224433899,
-0.01743100956082344,
0.006010894197970629,
-0.029277551919221878,
-0.02495484985411167,
0.001943756127730012,
-0.006571677513420582,
0.03110009804368019,
-0.024580994620919228,
-0.01673003099858761,
-0.010660720989108086,
-0.028927063569426537,
0.004532997030764818,
-0.01421818882226944,
-0.0320347361266613,
-0.016811810433864594,
0.011624567210674286,
0.017991792410612106,
0.019510580226778984,
-0.04166151210665703,
0.04911525547504425,
0.009883802384138107,
0.007664036005735397,
-0.022045787423849106,
-0.03535270318388939,
-0.014778971672058105,
0.010976161807775497,
-0.001692572026513517,
0.0009682271047495306,
0.0023176115937530994,
0.011647933162748814,
0.02273508347570896,
-0.05533060058951378,
0.019697507843375206,
-0.043694350868463516,
-0.03175434470176697,
-0.013961163349449635,
0.006624250672757626,
0.015176193788647652,
0.00045673156273551285,
0.016648249700665474,
0.005044127348810434,
0.008207295089960098,
-0.05252668634057045,
-0.00025866852956824005,
0.01220871601253748,
-0.004089043475687504,
0.01843574456870556,
-0.018447428941726685,
0.00169695308431983,
-0.0007937125628814101,
-0.006244553718715906,
-0.014323336072266102,
-0.02495484985411167,
0.015596780925989151,
0.035235874354839325,
0.008178086951375008,
0.007775024510920048,
0.07748153805732727,
0.016905274242162704,
-0.017127251252532005,
0.0002031743642874062,
-0.017477741464972496,
-0.0371285155415535,
0.03100663423538208,
-0.036170512437820435,
0.014884118922054768,
-0.002113159280270338,
-0.0069046420976519585,
-0.04390464723110199,
0.01112804003059864,
-0.022232715040445328,
0.010497159324586391,
-0.016800127923488617,
-0.014603727497160435,
-0.003101831767708063,
0.008773919194936752,
-0.017384277656674385,
-0.011642091907560825,
-0.023272499442100525,
0.011414273642003536,
-0.007763341534882784,
-0.028763500973582268,
0.0036801393143832684,
0.02055036462843418,
0.008756394498050213,
-0.03392738103866577,
-0.008002842776477337,
0.0054179830476641655,
-0.013435428962111473,
0.027641935274004936,
-0.01209188625216484,
-0.044628992676734924,
-0.03605368360877037,
-0.014825704507529736,
-0.016811810433864594,
-0.01486075296998024,
0.03280581161379814,
-0.04208210110664368,
0.015842122957110405,
0.013680771924555302,
-0.034394700080156326,
-0.015351437963545322,
0.032081469893455505,
-0.008329966105520725,
-0.0068111782893538475,
-0.03631070628762245,
0.004024787340313196,
0.0003397192049305886,
0.03219829872250557,
0.00211900076828897,
0.02486138604581356,
0.024113675579428673,
0.00590282678604126,
-0.024908117949962616,
0.013505526818335056,
-0.0017144775483757257,
0.07650016248226166,
0.018096938729286194,
0.012395643629133701,
-0.0026534972712397575,
-0.005637038964778185,
-0.01243069302290678,
0.011782287620007992,
-0.025819389149546623,
-0.00268124439753592,
0.025071678683161736,
0.018038524314761162,
0.005044127348810434,
-0.008867383003234863,
0.004051073919981718,
-0.018377330154180527,
0.02715124934911728,
0.0055114468559622765,
-0.009252921678125858,
0.03605368360877037,
0.000668850727379322,
-0.0016370778903365135,
-0.017769815400242805,
0.011718031018972397,
-0.022174298763275146,
0.04268961772322655,
0.002281102119013667,
-0.042058736085891724,
0.025725925341248512,
0.03091317042708397,
0.03715188428759575,
-0.0443953312933445,
0.0023745661601424217,
0.05575118958950043,
0.041801709681749344,
-0.011665457859635353,
0.03107673116028309,
0.020947586745023727,
-0.027969058603048325,
-0.03897442668676376,
0.033343229442834854,
-0.02588948793709278,
0.061452485620975494,
-0.027641935274004936,
-0.022559838369488716,
0.010532207787036896,
-0.003700584638863802,
0.013937797397375107,
-0.012150301598012447,
0.016811810433864594,
0.020690560340881348,
0.004892248660326004,
-0.0555175319314003,
0.02209251932799816,
0.016426272690296173,
0.0012895091203972697,
-0.010789234191179276,
0.021239660680294037,
0.011122198775410652,
0.005444269627332687,
0.019066626206040382,
-0.03383391723036766,
-0.035235874354839325,
0.00013672739441972226,
0.01897316239774227,
0.010023998096585274,
0.005473476834595203,
-0.026754029095172882,
-0.018704453483223915,
0.030819706618785858,
0.005321598146110773,
-0.013972846791148186,
-0.021601833403110504,
0.005619514267891645,
0.06098516657948494,
0.03518914058804512,
-0.027805497869849205,
-0.011285760439932346,
0.0021569705568253994,
-0.01952226273715496,
-0.026917589828372,
-0.013517210260033607,
0.020047996193170547,
0.04509631171822548,
-0.009171140380203724,
-0.00456804595887661,
0.010982003062963486,
-0.0023307548835873604,
-0.03413767367601395,
0.024580994620919228,
0.04731607809662819,
0.014276604168117046,
0.039768870919942856,
-0.04306347295641899,
-0.000925876316614449,
-0.0036830599419772625,
-0.007739975582808256,
0.0346049927175045,
0.0375724695622921,
-0.024978214874863625,
-0.012138618156313896,
-0.04028292000293732,
-0.050096627324819565,
0.010649038478732109,
-0.00995390024036169,
0.0029178247787058353,
0.00003358857429702766,
0.012874646112322807,
0.025165142491459846,
0.005850253161042929,
-0.001526089501567185,
-0.010467952117323875,
0.0026549575850367546,
0.024230504408478737,
0.0052573420107364655,
-0.001016419380903244,
-0.018026841804385185,
-0.011864067986607552,
-0.008995896205306053,
-0.010432902723550797,
-0.007208399940282106,
0.03895106166601181,
0.019674140959978104,
-0.002945571905001998,
-0.04032965376973152,
-0.01529302354902029,
-0.02486138604581356,
0.024580994620919228,
-0.04939564689993858,
-0.027828862890601158,
0.01698705554008484,
-0.003995579667389393,
-0.0015450743958353996,
0.03869403526186943,
0.03014209307730198,
0.0290438923984766,
0.0016195534262806177,
0.01563183031976223,
0.024978214874863625,
0.04850774258375168,
0.015012632124125957,
-0.016870226711034775,
0.005269024986773729,
-0.02206915244460106,
-0.013856016099452972,
0.027291445061564445,
0.0034523210488259792,
0.001680889050476253,
-0.014358384534716606,
0.0030755449552088976,
0.003615882946178317,
-0.010771709494292736,
0.02810925431549549,
-0.0027440404519438744,
-0.009434008039534092,
-0.036006949841976166,
-0.02241964265704155,
0.03191790729761124,
0.00435775239020586,
0.0008199993171729147,
0.004968188237398863,
0.0027367384172976017,
-0.010765868239104748,
-0.011414273642003536,
-0.023517843335866928,
0.03154405206441879,
0.020445218309760094,
-0.018342280760407448,
-0.031240293756127357,
0.02656710147857666,
-0.024066943675279617,
-0.01188743393868208,
0.01251247338950634,
0.009165299125015736,
0.013902748934924603,
-0.0029017606284469366,
-0.02640353888273239,
-0.002530826022848487,
0.024300603196024895,
0.008639564737677574,
-0.003951768856495619,
-0.011262394487857819,
0.014288286678493023,
-0.004570966586470604,
-0.03451152890920639,
0.009451532736420631,
0.0029251265805214643,
-0.007804231718182564,
-0.017407642677426338,
0.01849416084587574,
-0.01987275294959545,
-0.02476792223751545,
0.020737292245030403,
-0.0045242346823215485,
-0.022139251232147217,
0.008084623143076897,
0.007664036005735397,
-0.005368330050259829,
-0.024394067004323006,
0.00391671946272254,
0.016321126371622086,
-0.009626776911318302,
-0.010245975106954575,
-0.010035681538283825,
-0.01798010990023613,
-0.027641935274004936,
-0.013377014547586441,
-0.001609330764040351,
-0.015550049021840096,
-0.02074897661805153,
-0.007074045483022928,
-0.0006038641440682113,
-0.026099782437086105,
0.005692532751709223,
0.015655195340514183,
0.003209899179637432,
0.005587385967373848,
0.023821599781513214,
0.01040369551628828,
0.0071967169642448425,
0.009983108378946781,
0.02775876596570015,
-0.012547522783279419,
0.022314496338367462,
-0.013634040020406246,
0.016099149361252785,
-0.022150933742523193,
0.0025760976132005453,
-0.028763500973582268,
-0.021157879382371902,
-0.035820022225379944,
0.06416293978691101,
-0.01675339601933956,
-0.03862393647432327,
0.016297759488224983,
0.012010104954242706,
-0.00947489868849516,
0.015304706059396267,
0.008616198785603046,
-0.015000948682427406,
0.0045768083073198795,
0.008569466881453991,
0.022267764434218407,
0.007588096894323826,
-0.011618725955486298,
0.023389330133795738,
0.03303947299718857,
-0.006963057443499565,
0.005175561178475618,
0.007103253155946732,
0.021695297211408615,
0.020118094980716705,
0.014895802363753319,
-0.008931639604270458,
0.005923271644860506,
-0.005111304577440023,
0.019019894301891327,
0.040960535407066345,
0.019019894301891327,
0.01669498160481453,
0.03268898278474808,
0.0023000871296972036,
-0.00758225517347455,
-0.0030843073036521673,
-0.019288603216409683,
-0.008236502297222614,
-0.023073889315128326,
-0.03740890696644783,
-0.02267666719853878,
0.007669877726584673,
-0.015106095932424068,
-0.004194190725684166,
-0.028646672144532204,
0.0035691510420292616,
-0.007173351012170315,
-0.033950746059417725,
-0.018003474920988083,
-0.015141144394874573,
0.010286865755915642,
0.002116080140694976,
-0.003449400421231985,
-0.02817935310304165,
-0.017057154327630997,
0.006156931631267071,
-0.005981686525046825,
-0.011536944657564163,
0.02930091880261898,
0.025749292224645615,
0.013856016099452972,
0.004386959597468376,
0.016800127923488617,
-0.011554469354450703,
-0.01366908848285675,
-0.07210736721754074,
-0.02190559171140194,
-0.03698832169175148,
-0.004474582150578499,
0.005368330050259829,
-0.02335428074002266,
-0.022139251232147217,
-0.03252542018890381,
0.027361543849110603,
0.011735555715858936,
-0.023622989654541016,
0.008224818855524063,
-0.018575942143797874,
-0.007149985060095787,
0.0004242382710799575,
0.019475530833005905,
-0.016554785892367363,
0.025468900799751282,
-0.003551626577973366,
0.01177060417830944,
0.015117778442800045,
0.025725925341248512,
-0.012886328622698784,
-0.027314811944961548,
0.0039079575799405575,
0.024230504408478737,
-0.019674140959978104,
-0.009241238236427307,
-0.02836628071963787,
0.013271867297589779,
0.060424383729696274,
-0.021274710074067116,
0.004051073919981718,
-0.008955005556344986,
0.00104927783831954,
-0.010456268675625324,
0.021601833403110504,
0.029791604727506638,
0.04028292000293732,
0.04049321636557579,
-0.03280581161379814,
-0.02026997320353985,
-0.0070214723236858845,
-0.01856425777077675,
-0.027057785540819168,
-0.016928641125559807,
-0.007757499814033508,
0.018552575260400772,
-0.012921378016471863,
-0.016099149361252785,
-0.004521314054727554,
0.0034026685170829296,
0.01730249635875225,
0.0025980030186474323,
-0.01781654730439186,
-0.03238522633910179,
-0.030515948310494423,
-0.010812600143253803,
0.016554785892367363,
-0.011262394487857819,
0.013762552291154861,
0.024066943675279617,
0.03535270318388939,
-0.0380164235830307,
0.01843574456870556,
0.016321126371622086,
0.029067259281873703,
0.0032391068525612354,
-0.05663909763097763,
0.014206506311893463,
-0.004562204238027334,
-0.01336533110588789,
0.03827344998717308,
0.02673066221177578,
-0.018552575260400772,
0.00015260894724633545,
0.03367035463452339,
0.0016341571463271976,
-0.014183140359818935,
-0.02322576753795147,
-0.006431481335312128,
-0.009398958645761013,
-0.01900821179151535,
0.019966216757893562,
0.00818392913788557,
-0.024370700120925903,
0.00044103257823735476,
-0.016975373029708862,
-0.014124725013971329,
-0.009977266192436218,
0.02361130714416504,
-0.02997853234410286,
0.002615527482703328,
-0.006647616624832153,
-0.03091317042708397,
-0.06692012399435043,
0.018424062058329582,
0.006571677513420582,
-0.0273381769657135,
-0.012968109920620918,
-0.022080834954977036,
-0.004275971557945013,
0.04502621293067932,
-0.03521250933408737,
0.019440481439232826,
0.01840069703757763,
0.02247805707156658,
-0.007015630602836609,
0.014066310599446297,
0.0046060155145823956,
0.019861068576574326,
-0.018868016079068184,
-0.018026841804385185,
0.002780549693852663,
-0.006986423395574093,
0.04194190353155136,
-0.02434733510017395,
0.034721821546554565,
-0.005520208738744259,
-0.01148437149822712,
0.024487530812621117,
0.007173351012170315,
-0.02768866717815399,
0.03902116045355797,
-0.008569466881453991,
-0.008937480859458447,
-0.035562995821237564,
-0.019545629620552063,
-0.009060152806341648,
0.016192613169550896,
0.03792295977473259,
-0.012746132910251617,
-0.0008813349413685501,
0.02087748795747757,
0.04818061739206314,
-0.010567257180809975,
-0.025609096512198448,
-0.005660404916852713,
0.05673256143927574,
0.0320347361266613,
-0.0017363831866532564,
-0.006191980559378862,
0.014276604168117046,
-0.003516577649861574,
0.003279997268691659,
0.009831229224801064,
-0.04075024276971817,
-0.003884591395035386,
-0.016648249700665474,
0.017547838389873505,
0.014673825353384018,
0.004632302559912205,
0.007459584157913923,
0.010871014557778835,
-0.017746450379490852,
-0.012792864814400673,
-0.009580045007169247,
-0.0007542825187556446,
-0.025515632703900337,
0.0004315401311032474,
-0.008400063961744308,
-0.00934638548642397,
0.005342043470591307,
-0.00573342340067029,
0.0009886723710224032,
0.01792169362306595,
-0.010047364048659801,
-0.011834860779345036,
-0.02113451436161995,
-0.0461244136095047,
-0.023973478004336357,
0.020725609734654427,
0.006320493295788765,
-0.007897695526480675,
-0.06850900501012802,
-0.02988506853580475,
0.015818757936358452,
0.012103569693863392,
-0.03836691379547119,
-0.0005213530967012048,
-0.02026997320353985,
-0.0019145486876368523,
0.010818441398441792,
0.009790338575839996,
-0.007360278628766537,
0.011513578705489635,
-0.06701358407735825,
-0.009959742426872253,
-0.03233849257230759,
0.019241871312260628,
0.011823177337646484,
-0.019896117970347404,
0.018155353143811226,
0.004757894203066826,
-0.006495737936347723,
-0.029347650706768036,
-0.02885696478188038,
-0.016332808881998062,
-0.03782949596643448,
-0.010356963612139225,
-0.002205162774771452,
0.01196337305009365,
-0.007757499814033508,
0.007442059461027384,
-0.027875594794750214,
-0.021625200286507607,
-0.018120305612683296,
0.02113451436161995,
-0.0009156537125818431,
0.026497002691030502,
-0.014101359061896801,
-0.00007548301800852641,
0.009708558209240437,
0.022022420540452003,
-0.054115571081638336,
-0.011782287620007992,
0.030936535447835922,
-0.0036918222904205322,
-0.011922483332455158,
0.03110009804368019,
-0.005987528245896101,
-0.03708178550004959,
0.018856333568692207,
-0.020118094980716705,
0.01018171850591898,
0.008581150323152542,
-0.010018156841397285,
0.032922644168138504,
-0.01358730811625719,
0.025422168895602226,
0.011834860779345036,
0.02766530029475689,
-0.02757183648645878,
0.02344774454832077,
-0.01473223976790905,
-0.007687401957809925,
0.0042555262334644794,
0.001863435609266162,
-0.029160723090171814,
0.023237451910972595,
0.010911905206739902,
-0.008692138828337193,
0.02241964265704155,
0.004226318560540676,
-0.01882128417491913,
0.010059047490358353,
-0.04406820610165596,
-0.02016482688486576,
0.01814367063343525,
0.0017378436168655753,
0.017512788996100426,
0.03563309460878372,
0.0007849503308534622,
0.005587385967373848,
0.01621597819030285,
0.0005228134687058628,
-0.02640353888273239,
0.026333441957831383,
-0.017606254667043686,
-0.021344808861613274,
-0.024323968216776848,
0.004258446861058474,
0.14206506311893463,
0.0038612254429608583,
0.011513578705489635,
0.040516581386327744,
-0.010018156841397285,
-0.03254878893494606,
-0.004194190725684166,
0.001056579640135169,
0.013271867297589779,
-0.012956427410244942,
0.008213136345148087,
0.039161354303359985,
0.05430249869823456,
0.010187560692429543,
0.023108938708901405,
-0.019276920706033707,
0.01746605709195137,
0.04107736423611641,
-0.01243069302290678,
-0.0034990531858056784,
0.014767289161682129,
0.010876855812966824,
-0.006723556201905012,
0.0034318759571760893,
-0.03946511447429657,
-0.0034114306326955557,
0.009977266192436218,
0.0029820811469107866,
-0.03282918035984039,
0.018996529281139374,
0.015783708542585373,
0.025936219841241837,
0.02144995518028736,
-0.009112725965678692,
-0.012664352543652058,
-0.009235396981239319,
-0.01123902853578329,
-0.028810232877731323,
0.026870857924222946,
-0.002010933356359601,
-0.00019477721070870757,
-0.0052719456143677235,
-0.006665141321718693,
0.007214241195470095,
0.010561415925621986,
-0.004354831296950579,
-0.025655828416347504,
-0.00892579834908247,
-0.0073193879798054695,
0.01894979737699032,
0.00956836249679327,
-0.004632302559912205,
0.026380173861980438,
-0.020211558789014816,
-0.027197981253266335,
-0.04670856148004532,
0.0151645103469491,
-0.007442059461027384,
-0.009977266192436218,
-0.024744555354118347,
-0.033787183463573456,
0.015211242251098156,
0.001217220677062869,
-0.005768472328782082,
0.016613200306892395
] | 2024-07-08 | 47 | 38972512 | [
"T cell malignancies",
"CAR T cell therapy",
"Subsequent malignancies",
"subsequent malignancies",
"subsequent malignancy",
"CAR T products",
"hematologic malignancy",
"dermatologic malignancy",
"B cell non-Hodgkin lymphomas",
"higher risk",
"four different CAR T cell products",
"cumulative incidences",
"non-Hodgkin",
"more studies",
"adult patients",
"increasing age",
"molecular pathways",
"solid tumor",
"univariable analysis",
"survival",
"CAR",
"95% CI",
"The overall cumulative incidence",
"CI",
"patterns",
"ups",
"their potential risks",
"2 different medical centers",
"14%",
"19%"
] | [
"Chimeric antigen receptor (CAR) T-cells",
"Diffuse large B cell lymphoma",
"Follicular lymphoma",
"Myelodysplastic syndrome",
"Non-Hodgkin lymphoma",
"Subsequent malignancy",
"T cell malignancy",
"late effects"
] | 0 | 10.1016/j.jtct.2024.06.027 | [
"Lorenc",
"Shouval",
"Flynn",
"Devlin",
"Saldia",
"De Abia",
"De Lapuerta",
"Tomas",
"Cassanello",
"Leslie",
"Rejeski",
"Lin",
"Scordo",
"Shah",
"Palomba",
"Salles",
"Park",
"Giralt",
"Perales",
"Ip",
"Dahi"
] | [
"Department of Medicine, Weill Cornell Medical College, New York, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York; Adult Bone Marrow Transplantation Unit. Hospital Universitario Ramón y Cajal, Madrid, Spain.",
"Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York; Hospital Universitario Gregorio Marañón, Madrid, Spain.",
"Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Oncology and Hemato-Oncology, University of Milan, Italy; Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.",
"Lymphoma Service, Hackensack Meridian Health, New Jersey, New Jersey.",
"Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Cellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Lymphoma Service, Hackensack Meridian Health, New Jersey, New Jersey.",
"Department of Medicine, Weill Cornell Medical College, New York, New York; Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: [email protected]."
] | [
"38972512",
"28774879",
"28541315",
"29972754",
"29226797",
"30501490",
"32888407",
"32242358",
"34921238",
"34895487",
"34891224",
"35717989",
"35325065",
"31419568",
"37055515",
"33021872",
"33596362",
"34516954",
"31648294",
"34699592",
"36713414",
"33822002",
"31078660",
"33002134",
"30476975",
"24392036",
"27634019",
"30927975",
"23412096",
"27103007",
"8230284",
"34152404",
"32732355",
"25308294",
"28419413",
"33570626",
"32327504",
"37820582",
"38483155",
"38195751",
"37890149",
"10520006",
"37300386",
"35882844",
"18268277",
"38266761",
"29423555"
] | [] | 6.489958 | 4.707547 |
38972151 | 753 | Tumor-infiltrating T lymphocytes: A promising immunotherapeutic target for preventing immune escape in cholangiocarcinoma. | Cholangiocarcinoma (CCA) is becoming more common and deadly worldwide. Tumor-infiltrating T cell subtypes make distinct contributions to the immune system; collectively, they constitute a significant portion of the tumor microenvironment (TME) in CCA. By secreting cytokines and other chemicals, regulatory T cells (Tregs) decrease activated T cell responses, acting as immunosuppressors. Reduced CD8 | [
0.0023978427052497864,
-0.004765523597598076,
0.060757409781217575,
0.06698275357484818,
0.0014454919146373868,
0.013729534111917019,
0.01578051969408989,
0.023948265239596367,
-0.03841374069452286,
0.0013474669540300965,
-0.013427918776869774,
0.013246949762105942,
0.0008098374237306416,
0.03228491544723511,
0.037327926605939865,
-0.028014041483402252,
0.049392540007829666,
0.006017227657139301,
-0.004448827356100082,
0.04111621528863907,
-0.0016272151842713356,
-0.04232267662882805,
0.01596148870885372,
-0.0008573418599553406,
-0.045797284692525864,
-0.002972420072183013,
-0.035807784646749496,
0.011503612622618675,
-0.02303135395050049,
-0.01020063366740942,
0.01828995905816555,
-0.02581828087568283,
-0.049513187259435654,
-0.03339485824108124,
-0.05293953791260719,
0.014019085094332695,
0.04425301402807236,
0.02361045591533184,
-0.0018609671387821436,
-0.0015027988702058792,
0.006551086902618408,
0.049899253994226456,
-0.008668427355587482,
0.05173307657241821,
-0.027603844180703163,
-0.07098820805549622,
-0.01769879274070263,
-0.04292590543627739,
0.0024943596217781305,
-0.015189352445304394,
-0.01552716176956892,
0.014103537425398827,
0.017554016783833504,
0.04249158129096031,
-0.0669344961643219,
0.02090798132121563,
-0.03214013949036598,
0.04111621528863907,
-0.017119690775871277,
0.003712885780259967,
-0.012185263447463512,
-0.03641101345419884,
-0.000005066196536063217,
-0.03477022424340248,
-0.04589380323886871,
-0.05067139118909836,
-0.013464112766087055,
-0.003559062024578452,
0.0067984117195010185,
-0.01442928146570921,
-0.015647808089852333,
-0.02371903695166111,
-0.00919927004724741,
0.059743981808423996,
0.09149805456399918,
-0.02673519030213356,
-0.02473246492445469,
-0.0016513444716110826,
-0.010393667966127396,
-0.027169518172740936,
0.019520550966262817,
0.017710857093334198,
0.00879510585218668,
-0.013439983129501343,
0.03214013949036598,
-0.026662804186344147,
0.0005568574997596443,
0.006569183897227049,
-0.051395267248153687,
-0.012511007487773895,
0.015201417729258537,
0.050092291086912155,
-0.009066559374332428,
0.037834640592336655,
-0.0014862100360915065,
0.003420318942517042,
-0.009699951857328415,
-0.057331059128046036,
0.01637168601155281,
0.011527741327881813,
0.014055279083549976,
-0.020883852615952492,
-0.00719051156193018,
-0.009410400874912739,
0.0273384228348732,
-0.00228775292634964,
-0.08517619222402573,
-0.009181173518300056,
-0.00534764165058732,
-0.015659872442483902,
0.07151904702186584,
0.047993045300245285,
-0.015744324773550034,
0.00994124449789524,
-0.015708131715655327,
-0.045266442000865936,
0.0008829791331663728,
0.00024694763123989105,
0.010484152473509312,
0.013572693802416325,
-0.019954876974225044,
0.02060636505484581,
-0.0037581282667815685,
-0.029775474220514297,
-0.0029271775856614113,
-0.007528320886194706,
0.045797284692525864,
-0.008686523884534836,
-0.07171208411455154,
-0.061046961694955826,
0.017252402380108833,
-0.006870799232274294,
0.02644564025104046,
0.006418376229703426,
-0.044856246560811996,
-0.04671419784426689,
-0.04179183393716812,
0.02333296835422516,
-0.05096094310283661,
-0.03486674278974533,
0.025408083572983742,
0.023357098922133446,
0.02411716990172863,
-0.01557542011141777,
-0.05829622969031334,
-0.08681698143482208,
-0.05308431386947632,
0.0052511245012283325,
-0.013572693802416325,
0.017626404762268066,
-0.011895712465047836,
0.05154004320502281,
0.026300864294171333,
-0.021547405049204826,
-0.04159880056977272,
-0.012462749145925045,
-0.007624838035553694,
0.024249879643321037,
-0.04606270790100098,
-0.03969258815050125,
-0.016444072127342224,
-0.003375076688826084,
-0.024587688967585564,
-0.006002146750688553,
0.02873791754245758,
0.007781677879393101,
-0.03115084022283554,
0.038437869399785995,
-0.030016766861081123,
0.01828995905816555,
-0.0422261580824852,
-0.05332560837268829,
-0.0856105238199234,
0.007661031559109688,
-0.0675135999917984,
-0.01971358433365822,
0.02622847817838192,
0.027000613510608673,
0.0029784522484987974,
0.0011189932702109218,
-0.009591370820999146,
0.07798568159341812,
0.0114070950075984,
0.006484731566160917,
-0.022464316338300705,
0.01627516746520996,
0.034022219479084015,
0.029606569558382034,
-0.02893095090985298,
-0.0021595663856714964,
-0.0018624752992764115,
-0.013596823439002037,
0.037520959973335266,
0.006774282548576593,
-0.01888112537562847,
-0.013958761468529701,
0.02905159816145897,
0.053422123193740845,
0.0029859927017241716,
0.02130611427128315,
0.039451297372579575,
-0.01909828931093216,
-0.04258809611201286,
0.003227285109460354,
0.006448537576943636,
-0.02654215693473816,
0.019737713038921356,
0.06336336582899094,
0.012474813498556614,
0.027796877548098564,
0.018760479986667633,
-0.019351646304130554,
-0.0033509472850710154,
0.012462749145925045,
0.011974132619798183,
-0.009144979529082775,
0.0007566777057945728,
-0.007371481042355299,
0.04179183393716812,
0.01477915607392788,
0.015840841457247734,
0.02370697259902954,
0.03223665803670883,
0.009675823152065277,
0.0036404982674866915,
-0.03194710612297058,
0.01547890342772007,
-0.002310374053195119,
0.012679912149906158,
-0.0009847743203863502,
-0.009356110356748104,
0.02352600358426571,
0.012511007487773895,
-0.05062313377857208,
-0.050092291086912155,
-0.02642151154577732,
0.00688286405056715,
-0.028593141585588455,
0.044590823352336884,
-0.013838116079568863,
-0.0022123490925878286,
-0.0033599957823753357,
0.017035238444805145,
-0.010381602682173252,
-0.0395960733294487,
0.011183899827301502,
0.014863608404994011,
-0.039354778826236725,
-0.0212095957249403,
0.04193660989403725,
-0.019025901332497597,
0.015092835761606693,
-0.013379660435020924,
-0.019037965685129166,
0.01436895877122879,
0.021655987948179245,
0.03546997532248497,
-0.036724694073200226,
0.015442709438502789,
-0.03534932807087898,
0.00740767503157258,
0.01331933680921793,
-0.020533978939056396,
-0.07195337861776352,
-0.019351646304130554,
0.006581248715519905,
-0.0003227285051252693,
-0.03312943875789642,
0.0273384228348732,
0.0273384228348732,
0.06997478008270264,
0.03812418878078461,
0.026373252272605896,
0.010387634858489037,
-0.024346396327018738,
0.008933848701417446,
0.010478119365870953,
0.0007766596972942352,
-0.00603230856359005,
0.023948265239596367,
-0.07325635105371475,
-0.016263103112578392,
0.01100293081253767,
0.014658509753644466,
-0.014212118461728096,
-0.04685897380113602,
-0.008933848701417446,
0.004101969767361879,
0.021945537999272346,
-0.07981950789690018,
0.05559375509619713,
-0.03711076080799103,
-0.04314307123422623,
-0.0013195674400776625,
-0.055738531053066254,
0.03969258815050125,
-0.010291118174791336,
-0.02201792597770691,
-0.017771180719137192,
0.04570076987147331,
-0.038655031472444534,
-0.01970151998102665,
-0.04434953257441521,
0.00590261397883296,
0.0394030399620533,
0.039644330739974976,
0.041260991245508194,
-0.013283142820000648,
-0.004355326760560274,
0.025408083572983742,
0.012330038473010063,
0.023139934986829758,
0.007093994878232479,
0.03469783812761307,
-0.006267568562179804,
0.0029332099948078394,
0.018615704029798508,
-0.053132571280002594,
0.0010247384198009968,
-0.011648387648165226,
-0.018446799367666245,
-0.010827993974089622,
-0.02864140085875988,
0.009947276674211025,
0.027314292266964912,
-0.009724081493914127,
0.013476177118718624,
0.04159880056977272,
-0.0003097213339060545,
-0.0482584685087204,
0.04635225981473923,
-0.01718001440167427,
0.03419112414121628,
-0.01658884808421135,
0.0031699780374765396,
-0.03016154281795025,
-0.025576988235116005,
-0.02219889499247074,
-0.010924510657787323,
0.011413127183914185,
0.006973348557949066,
0.010266989469528198,
-0.010725444182753563,
0.050719648599624634,
0.04302242398262024,
0.027000613510608673,
-0.011750936508178711,
0.019230999052524567,
0.02069081738591194,
0.02876204624772072,
0.019544679671525955,
0.03464958071708679,
0.012414490804076195,
-0.012981527484953403,
-0.00995330885052681,
0.006870799232274294,
-0.049899253994226456,
-0.00893988087773323,
0.04430127516388893,
0.053904708474874496,
0.0024868191685527563,
-0.026566285640001297,
0.037424441426992416,
0.029461795464158058,
0.04239506274461746,
0.054918136447668076,
-0.03204362094402313,
-0.024877240881323814,
-0.01547890342772007,
-0.010194601491093636,
0.02531156688928604,
-0.003396189771592617,
-0.007890259847044945,
-0.0542907752096653,
-0.0009515966521576047,
0.002972420072183013,
0.012571331113576889,
-0.008173777721822262,
0.02480485290288925,
0.008469360880553722,
0.04060950130224228,
-0.031802330166101456,
0.04804130643606186,
-0.003830515779554844,
0.008421102538704872,
-0.0005915432702749968,
0.006526957731693983,
-0.044156499207019806,
-0.06756185740232468,
0.0241292342543602,
0.03086129017174244,
0.004370407667011023,
-0.0035258843563497066,
0.0273384228348732,
-0.022078249603509903,
0.026904094964265823,
0.018422670662403107,
0.08039860427379608,
0.014284506440162659,
0.03518042340874672,
0.021957602351903915,
-0.018217571079730988,
-0.014236248098313808,
-0.029485924169421196,
-0.00030934432288631797,
0.013536499813199043,
0.05926140025258064,
0.004599635023623705,
0.02251257561147213,
-0.031826458871364594,
0.027796877548098564,
0.027217775583267212,
0.016962852329015732,
0.059743981808423996,
0.000030491433790302835,
-0.026711061596870422,
-0.04258809611201286,
0.01800040900707245,
0.022066185250878334,
0.022898642346262932,
-0.01767466403543949,
-0.0018881125142797828,
0.0036857405211776495,
-0.017710857093334198,
0.016456138342618942,
-0.040947310626506805,
0.015539227053523064,
0.026083702221512794,
-0.022886577993631363,
-0.03749683126807213,
0.012643718160688877,
0.054628584533929825,
-0.06572803109884262,
0.0019288306357339025,
0.017216209322214127,
-0.003746063681319356,
-0.017517823725938797,
-0.021257854998111725,
-0.08889209479093552,
0.013379660435020924,
-0.029317019507288933,
0.0015382386045530438,
-0.004979670513421297,
-0.035928428173065186,
0.03546997532248497,
0.04468734189867973,
0.011569967493414879,
-0.027169518172740936,
-0.01170267816632986,
-0.00635805306956172,
-0.00799280870705843,
-0.03228491544723511,
-0.01044795848429203,
0.010158407501876354,
-0.012969463132321835,
-0.004159276839345694,
0.012028423137962818,
-0.042757000774145126,
0.006611410062760115,
-0.0010322787566110492,
0.04816194996237755,
-0.07798568159341812,
0.011129609309136868,
-0.011793162673711777,
-0.018374411389231682,
0.005175720900297165,
0.01698698103427887,
-0.023357098922133446,
0.03013741225004196,
-0.008873526006937027,
0.04760697856545448,
-0.02099243365228176,
-0.0034233350306749344,
0.003601288190111518,
0.007805807050317526,
-0.01900177262723446,
0.05014054849743843,
-0.011419160291552544,
0.014477540738880634,
-0.03353963419795036,
0.00021452397049870342,
0.014248312450945377,
-0.02431020326912403,
0.006484731566160917,
0.03691772744059563,
0.04253983870148659,
-0.028520753607153893,
0.006273600738495588,
0.016637107357382774,
0.010936575010418892,
-0.009591370820999146,
0.003718918189406395,
0.02765210159122944,
-0.011895712465047836,
0.005917694419622421,
-0.03366028144955635,
-0.014212118461728096,
-0.03187471628189087,
-0.03320182487368584,
0.00449708616361022,
-0.020678753033280373,
0.016202781349420547,
0.011135641485452652,
-0.053711675107479095,
0.0029875007458031178,
0.049513187259435654,
0.014296570792794228,
0.06872005760669708,
0.03797941282391548,
-0.027217775583267212,
-0.02832772023975849,
0.022693544626235962,
0.01979803666472435,
-0.019568808376789093,
-0.03163342550396919,
-0.0015774486819282174,
-0.020871788263320923,
-0.02934114821255207,
0.040947310626506805,
-0.005046025849878788,
0.0030523480381816626,
-0.004328181501477957,
0.02250051125884056,
-0.049995772540569305,
0.025094402953982353,
-0.023296775296330452,
-0.010966736823320389,
-0.020932110026478767,
-0.02692822553217411,
-0.04101969674229622,
0.008855428546667099,
-0.02038920298218727,
0.022777996957302094,
0.028810305520892143,
-0.027362551540136337,
0.014586121775209904,
-0.0008709145477041602,
0.04454256594181061,
-0.013476177118718624,
-0.03725553676486015,
0.008421102538704872,
-0.030426964163780212,
0.004491053521633148,
-0.024056846275925636,
-0.005896581336855888,
0.045266442000865936,
0.009211335331201553,
-0.030426964163780212,
0.008734782226383686,
0.010882284492254257,
0.00598103366792202,
-0.05043010041117668,
-0.0034504805225878954,
0.0018564428901299834,
0.010616863146424294,
-0.006243439391255379,
0.01060479786247015,
-0.02502201497554779,
-0.00740767503157258,
-0.016311362385749817,
-0.025287436321377754,
-0.017903892323374748,
0.006174067500978708,
-0.03720727935433388,
0.005597982089966536,
0.03204362094402313,
-0.01044795848429203,
-0.020618431270122528,
0.008179809898138046,
0.023091677576303482,
0.009114817716181278,
-0.009518982842564583,
-0.023936200886964798,
-0.014525799080729485,
0.013234884478151798,
-0.017771180719137192,
-0.04058537259697914,
0.00022583454847335815,
-0.011841421946883202,
0.0029136049561202526,
-0.025552859529852867,
0.011189932003617287,
-0.00989298615604639,
0.021583599969744682,
0.013379660435020924,
0.0040054526180028915,
0.0038546451833099127,
0.013741598464548588,
-0.017433371394872665,
-0.017421307042241096,
0.020533978939056396,
0.013693340122699738,
0.024141298606991768,
-0.015116965398192406,
0.0011122068390250206,
0.04630399867892265,
0.0137657281011343,
-0.003770192852243781,
-0.040657758712768555,
0.018350282683968544,
-0.001169513794593513,
0.008614136837422848,
-0.008819234557449818,
-0.0037732089404016733,
-0.022874513640999794,
0.03636275604367256,
0.006436473224312067,
0.02272973768413067,
0.007805807050317526,
0.0021821875125169754,
0.024491172283887863,
0.035228680819272995,
0.008964010514318943,
-0.018265830352902412,
0.03911348804831505,
-0.010164439678192139,
-0.007106059230864048,
-0.03288814425468445,
-0.013886374421417713,
0.00011027813889086246,
-0.01808486133813858,
-0.01311423908919096,
-0.03346724808216095,
-0.03443241864442825,
-0.03650753200054169,
-0.03276750072836876,
0.03269511088728905,
-0.024575624614953995,
0.007600708864629269,
-0.0038998874370008707,
0.012486878782510757,
-0.0012977003352716565,
0.009440562687814236,
0.011877615004777908,
-0.0005613816902041435,
-0.014344829134643078,
0.0012094778940081596,
-0.004252777434885502,
-0.012631653808057308,
-0.017433371394872665,
0.016950786113739014,
0.040440596640110016,
-0.0016498363111168146,
-0.003878774354234338,
0.003851628862321377,
0.016106262803077698,
0.03235730156302452,
-0.02110101468861103,
0.024044781923294067,
-0.01075560599565506,
-0.024780722334980965,
-0.04159880056977272,
-0.005712596233934164,
-0.009512950666248798,
0.0023571245837956667,
-0.00904243066906929,
0.025866538286209106,
0.027893394231796265,
0.011799195781350136,
0.05708976835012436,
-0.01808486133813858,
0.022681480273604393,
-0.006155970972031355,
-0.005193817429244518,
-0.025046145543456078,
-0.030402835458517075,
-0.013452047482132912,
-0.008390940725803375,
-0.02431020326912403,
-0.0030810015741735697,
0.07388371229171753,
0.023465679958462715,
0.025745892897248268,
-0.012082713656127453,
0.027821006253361702,
0.0343359000980854,
-0.00009345365106128156,
0.017529888078570366,
-0.03025805950164795,
-0.006961284205317497,
0.00029520608950406313,
0.037545088678598404,
-0.000527449999935925,
-0.019653260707855225,
-0.00449406960979104,
0.004720281343907118,
0.010598765686154366,
-0.009277690201997757,
0.010990866459906101,
-0.022138571366667747,
0.013065979816019535,
0.0050399936735630035,
0.0035650942008942366,
-0.005495433229953051,
-0.04717265069484711,
0.013283142820000648,
-0.0016347556374967098,
-0.012740235775709152,
-0.01387430913746357,
0.014163860119879246,
0.03163342550396919,
0.008131551556289196,
-0.007878194563090801,
-0.024370526894927025,
0.038848064839839935,
-0.012070649303495884,
-0.030402835458517075,
0.0022802127059549093,
0.008463328704237938,
-0.017903892323374748,
-0.02340535633265972,
0.04073014855384827,
-0.030113283544778824,
0.004469940438866615,
-0.014055279083549976,
0.0050852359272539616,
-0.01748163066804409,
0.046593550592660904,
0.006213277578353882,
-0.02301928959786892,
-0.00954311154782772,
0.01660091243684292,
-0.029871990904211998,
-0.005504481494426727,
0.03165755420923233,
0.0075222887098789215,
-0.047003746032714844,
0.020256491377949715,
-0.01827789470553398,
0.0011310578556731343,
-0.01676981709897518,
-0.02832772023975849,
0.00660537788644433,
-0.008378876373171806,
-0.03930652141571045,
0.04304655268788338,
-0.0418400913476944,
-0.051491785794496536,
0.013439983129501343,
0.014887737110257149,
0.011624258011579514,
-0.027821006253361702,
-0.011889680288732052,
-0.03387744352221489,
-0.02431020326912403,
0.047486331313848495,
0.0011529249604791403,
0.0027929588686674833,
0.016226910054683685,
-0.022174766287207603,
0.0023752215784043074,
0.00814361684024334,
-0.005709580145776272,
-0.007745483890175819,
0.04268461465835571,
-0.04220202937722206,
0.005208898335695267,
0.012076681479811668,
-0.0031880750320851803,
0.014682638458907604,
-0.006460602395236492,
0.016637107357382774,
0.015322063118219376,
-0.005139526911079884,
-0.007998840883374214,
0.029317019507288933,
-0.0028698707465082407,
0.008970042690634727,
-0.004334213677793741,
0.026711061596870422,
-0.024901369586586952,
-0.03245382010936737,
0.002544126007705927,
-0.013958761468529701,
0.007395610213279724,
0.015635743737220764,
-0.0343359000980854,
-0.044059980660676956,
-0.007268931716680527,
-0.0016498363111168146,
0.03218839690089226,
-0.008686523884534836,
-0.02502201497554779,
-0.00794455036520958,
-0.030402835458517075,
-0.016311362385749817,
0.026904094964265823,
-0.011135641485452652,
-0.02230747602880001,
0.019013836979866028,
0.004780604504048824,
0.03539758548140526,
-0.00944659486413002,
0.04594206064939499,
-0.024587688967585564,
0.020075522363185883,
0.0335637629032135,
-0.07007129490375519,
-0.027676232159137726,
0.013186626136302948,
-0.004937444347888231,
0.01607006974518299,
0.011183899827301502,
0.027700360864400864,
-0.013789856806397438,
0.01381398644298315,
-0.013886374421417713,
-0.010737509466707706,
0.002639134880155325,
0.03838961198925972,
-0.018350282683968544,
-0.0005764624802395701,
0.0031156872864812613,
-0.03153690695762634,
-0.04893408715724945,
0.0062856655567884445,
0.042563967406749725,
0.017940085381269455,
0.011105479672551155,
-0.00044035850442014635,
0.0614812895655632,
0.015213482081890106,
-0.0012788494350388646,
-0.031898848712444305,
-0.004460892174392939,
-0.02310374192893505,
-0.005622111726552248,
-0.014501669444143772,
0.0211130790412426,
-0.02864140085875988,
0.028906822204589844,
-0.009911082684993744,
-0.04512166604399681,
0.011726807802915573,
-0.027000613510608673,
-0.014079407788813114,
0.004050695337355137,
0.006291697733104229,
0.00933801382780075,
0.025673504918813705,
0.07504191994667053,
-0.014031149446964264,
-0.004304052330553532,
0.0003001073491759598,
0.0027718457859009504,
-0.02071494795382023,
-0.02041333168745041,
0.026566285640001297,
-0.03404634818434715,
-0.0032423657830804586,
-0.022138571366667747,
-0.0025305533781647682,
-0.009959341026842594,
0.021076885983347893,
0.019013836979866028,
0.039041101932525635,
0.0023797457106411457,
-0.01999107003211975,
0.009886953979730606,
-0.0014183465391397476,
0.00416832510381937,
-0.02523917891085148,
-0.02651802822947502,
-0.023972393944859505,
0.03860677406191826,
-0.07914388924837112,
-0.009669790044426918,
0.0007593168411403894,
0.009114817716181278,
-0.025456340983510017,
0.01859157532453537,
-0.0054622553288936615,
-0.025890668854117393,
-0.03045109286904335,
-0.006876831874251366,
-0.02423781529068947,
0.024756593629717827,
-0.021245790645480156,
-0.026759320870041847,
-0.0059297592379152775,
0.021873150020837784,
0.0039692590944468975,
0.006659668404608965,
-0.011950002983212471,
0.02071494795382023,
-0.0007419739267788827,
-0.01377779245376587,
0.01767466403543949,
-0.01377779245376587,
-0.005236043594777584,
-0.00487108901143074,
-0.009874888695776463,
0.010375570505857468,
-0.025359824299812317,
-0.0009485805057920516,
0.009036398492753506,
-0.00864429771900177,
0.0356147475540638,
0.00046486477367579937,
0.004210551269352436,
-0.026059573516249657,
-0.0011303038336336613,
-0.01787976175546646,
0.02953418157994747,
-0.027072999626398087,
0.009561209008097649,
-0.01506870612502098,
0.031126711517572403,
-0.012191295623779297,
-0.01105118915438652,
-0.00959740299731493,
0.004584554582834244,
-0.006424408406019211,
0.0017267483053728938,
0.0011348280822858214,
-0.005987066309899092,
0.003254430368542671,
0.057041507214307785,
0.02330883964896202,
0.01054447516798973,
-0.032309044152498245,
-0.012933269143104553,
0.0246118176728487,
0.022874513640999794,
0.01720414310693741,
0.013898438774049282,
-0.008390940725803375,
-0.0004203764838166535,
0.03419112414121628,
0.009235464036464691,
0.0071663823910057545,
0.009796468541026115,
0.04794478788971901,
-0.00959740299731493,
0.028569012880325317,
0.01880873739719391,
0.00019048899412155151,
0.009307852014899254,
-0.025552859529852867,
-0.03800354525446892,
-0.021354371681809425,
0.018362347036600113,
-0.013307272456586361,
-0.0361938513815403,
0.010230795480310917,
0.014634380117058754,
0.027603844180703163,
-0.0019785971380770206,
-0.045266442000865936,
0.02482898160815239,
0.01427244208753109,
0.021149273961782455,
0.011829356662929058,
0.03817244619131088,
0.009024333208799362,
0.010224763303995132,
-0.001496766577474773,
0.0009900525910779834,
0.025142662227153778,
-0.0027974830009043217,
0.01205255277454853,
-0.0016694413498044014,
-0.009440562687814236,
0.013934632763266563,
0.01044795848429203,
0.041960738599300385,
-0.0026557238306850195,
-0.0033147535286843777,
-0.06543847918510437,
0.03407047688961029,
0.006333923898637295,
-0.04512166604399681,
0.0009998551104217768,
-0.04239506274461746,
0.007805807050317526,
0.029992638155817986,
-0.001471883268095553,
-0.049030601978302,
0.02161979302763939,
0.005332560744136572,
0.04490450397133827,
0.01639581471681595,
-0.05318083241581917,
0.052215661853551865,
-0.016528524458408356,
0.008970042690634727,
-0.01160616148263216,
0.020328879356384277,
-0.033829186111688614,
0.027965782210230827,
0.005610046908259392,
-0.010665121488273144,
-0.030692385509610176,
-0.014851543121039867,
0.004340245854109526,
-0.016106262803077698,
-0.009802501648664474,
-0.006810476072132587,
0.05052661523222923,
0.06379769742488861,
0.0008030510507524014,
0.009808533824980259,
0.025552859529852867,
0.02259702794253826,
-0.05458032712340355,
-0.03759334608912468,
0.038630902767181396,
0.01000156719237566,
0.014055279083549976,
-0.020353008061647415,
-0.008258230052888393,
0.00014939389075152576,
-0.0010684726294130087,
0.0009515966521576047,
0.00869858916848898,
-0.009555176831781864,
0.007636902388185263,
-0.00024223489162977785,
-0.019532615318894386,
-0.0010820453753694892,
0.022379864007234573,
-0.02260909229516983,
0.021643923595547676,
0.03165755420923233,
0.03226078674197197,
-0.013488241471350193,
0.028713788837194443,
-0.022681480273604393,
0.042153771966695786,
0.0339498333632946,
-0.00457550585269928,
0.009283722378313541,
0.013838116079568863,
-0.004961573518812656,
-0.032091882079839706,
0.001103158458136022,
-0.007148285396397114,
0.05134700983762741,
0.06852702796459198,
-0.01648026704788208,
-0.03286401554942131,
-0.00424976134672761,
0.011437256820499897,
0.03575952351093292,
-0.04063363000750542,
-0.019436098635196686,
-0.039547815918922424,
0.02410510554909706,
0.015177288092672825,
0.029413536190986633,
0.03889632597565651,
0.012348135001957417,
0.030330447480082512,
0.0018790641333907843,
-0.007323222700506449,
0.03274337202310562,
-0.012933269143104553,
0.013608887791633606,
0.002081146463751793,
-0.016058005392551422,
0.018314087763428688,
0.007015574723482132,
-0.0018911287188529968,
-0.02019616961479187,
-0.044470179826021194,
-0.021776633337140083,
0.001615150598809123,
-0.0030764772091060877,
0.00640631141141057,
-0.016637107357382774,
0.0030312349554151297,
0.04454256594181061,
-0.04760697856545448,
-0.009368174709379673,
-0.013560629449784756,
-0.022548768669366837,
-0.027362551540136337,
-0.007268931716680527,
0.012836752459406853,
-0.013946697115898132,
0.02613195963203907,
0.032912276685237885,
0.05728280171751976,
-0.013391724787652493,
-0.0185795109719038,
-0.011449321173131466,
-0.029075726866722107,
-0.05665544047951698,
0.0022756883408874273,
0.0004377193981781602,
0.017505759373307228,
-0.018941449001431465,
-0.03148864954710007,
0.02613195963203907,
-0.031392134726047516,
-0.02282625436782837,
-0.05636588856577873,
0.014851543121039867,
-0.002643659245222807,
-0.023284710943698883,
-0.002017807215452194,
-0.016311362385749817,
0.013331402093172073,
-0.012022390961647034,
-0.01939990371465683,
0.043360233306884766,
0.009319916367530823,
-0.045580122619867325,
0.0039149681106209755,
0.010073955170810223,
0.013403789140284061,
0.020075522363185883,
-0.013041851110756397,
0.004789652768522501,
0.035132165998220444,
-0.012336070649325848,
-0.01728859543800354,
0.01166648417711258,
-0.014682638458907604,
0.007075897883623838,
-0.029123986139893532,
-0.03684534132480621,
0.0038425805978477,
0.023441551253199577,
-0.016637107357382774,
0.00716035021468997,
0.00012894059182144701,
0.021269919350743294,
-0.029461795464158058,
-0.01959293708205223,
-0.005480352323502302,
0.007709290366619825,
0.008119487203657627,
-0.01281262282282114,
0.0036435143556445837,
0.0028924918733537197,
0.0032333172857761383,
0.02099243365228176,
0.010363506153225899,
-0.0063761500641703606,
0.013355530798435211,
0.033732667565345764,
0.009591370820999146,
-0.003933065105229616,
-0.021547405049204826,
0.020835593342781067,
-0.06080567091703415,
0.054435551166534424,
-0.018241701647639275,
-0.04652116447687149,
0.03016154281795025,
0.017324790358543396,
-0.013090109452605247,
0.00487108901143074,
0.03409460932016373,
0.0014394596219062805,
0.02431020326912403,
-0.01145535334944725,
0.04138163477182388,
0.022753868252038956,
-0.017240338027477264,
-0.014742962084710598,
0.02373110130429268,
-0.01820550672709942,
-0.010821961797773838,
-0.03571126610040665,
-0.013886374421417713,
-0.00033328504650853574,
-0.019315451383590698,
0.004279922693967819,
-0.0021459937561303377,
0.000003013208697666414,
0.015720196068286896,
0.0168783999979496,
-0.003905919846147299,
-0.041960738599300385,
0.031319744884967804,
-0.01190174464136362,
-0.010532410815358162,
-0.014984254725277424,
-0.0029588472098112106,
-0.01809692569077015,
-0.016202781349420547,
-0.05216740444302559,
-0.008427134715020657,
0.0042256321758031845,
0.0018504105973988771,
0.013886374421417713,
-0.014682638458907604,
0.037231408059597015,
-0.007697225548326969,
-0.02895508147776127,
-0.005842290818691254,
-0.02231954224407673,
-0.021173402667045593,
-0.022150637581944466,
0.009699951857328415,
-0.05245695635676384,
-0.033105310052633286,
0.008553813211619854,
-0.000058673624153016135,
0.017819439992308617,
0.012118907645344734,
0.006201213225722313,
0.0018081844318658113,
-0.009193237870931625,
0.022247154265642166,
-0.001705635222606361,
0.011485515162348747,
-0.04751046001911163,
0.022681480273604393,
-0.016806012019515038,
-0.009820598177611828,
-0.005890549160540104,
-0.019472291693091393,
-0.020763205364346504,
-0.021836956962943077,
-0.026493899524211884,
-0.023574260994791985,
0.013536499813199043,
0.01382605079561472,
-0.023272646591067314,
0.01211287546902895,
-0.014791220426559448,
0.012800558470189571,
-0.015189352445304394,
-0.019725648686289787,
0.003109655110165477,
0.0013286159373819828,
-0.00022432647529058158,
0.00355604593642056,
-0.02823120355606079,
0.0033871412742882967,
-0.00944659486413002,
-0.008577942848205566,
-0.012203359976410866,
0.0010669645853340626,
0.024648012593388557,
0.016552655026316643,
0.008656363002955914,
-0.003224268788471818,
0.04772762581706047,
-0.02774861827492714,
-0.00995330885052681,
0.009591370820999146,
0.046279869973659515,
0.02381555363535881,
0.022391928359866142,
0.019218934699892998,
-0.012752300128340721,
-0.0001732403616188094,
-0.028569012880325317,
-0.0020404283422976732,
0.014356894418597221,
-0.03344311937689781,
0.007118124049156904,
-0.008813202381134033,
-0.027796877548098564,
-0.011485515162348747,
-0.000028724156436510384,
0.007751516532152891,
0.011539805680513382,
0.027579713612794876,
0.015213482081890106,
0.013729534111917019,
-0.0394030399620533,
0.01497218944132328,
-0.017252402380108833,
0.0016784898471087217,
0.02119753137230873,
-0.02673519030213356,
0.011744904331862926,
-0.0018338217632845044,
0.04007865861058235,
-0.011545838788151741,
0.006575216073542833,
-0.0004467678372748196,
-0.04157467186450958,
-0.008222036063671112,
0.009205303154885769,
0.025649376213550568,
0.01920687034726143,
0.0395960733294487,
-0.023248516023159027,
-0.012022390961647034,
0.024080974981188774,
0.01597355306148529,
-0.0022606076672673225,
0.014055279083549976,
-0.009766307659447193,
-0.01547890342772007,
0.03257446736097336,
-0.014055279083549976,
0.015322063118219376,
0.00513047818094492,
0.009699951857328415,
0.0005342363147065043,
0.010266989469528198,
-0.03185058757662773,
0.021776633337140083,
0.008740815334022045,
-0.015104900114238262,
0.0048288628458976746,
-0.03344311937689781,
-0.04010278731584549,
-0.030475221574306488,
0.012848816812038422,
-0.0016498363111168146,
0.028182944282889366,
0.008777008391916752,
0.017915956676006317,
0.02876204624772072,
0.0006571445846930146,
-0.011956035159528255,
0.06302555650472641,
0.0003510049427859485,
-0.00537780299782753,
-0.0027673214208334684,
-0.0015073231188580394,
0.043866947293281555,
-0.004433746915310621,
-0.01015237532556057,
-0.01609419845044613,
0.011672517284750938,
0.03766573593020439,
-0.011165803298354149,
0.028182944282889366,
0.030113283544778824,
-0.005465271417051554,
0.0002769206475932151,
-0.02370697259902954,
-0.018820801749825478,
0.030282188206911087,
0.002764305332675576,
0.0009267134009860456,
-0.010918478481471539,
0.003911952022463083,
-0.032116010785102844,
0.024901369586586952,
0.019424032419919968,
0.001359531539492309,
-0.007654999382793903,
0.04360152408480644,
0.029389407485723495,
-0.01260752510279417,
0.0076791285537183285,
0.023586325347423553,
0.02040126733481884,
-0.002595400670543313,
0.011563935317099094,
-0.018338218331336975,
-0.01276436448097229,
-0.03498739004135132,
0.046690069139003754,
-0.0033117374405264854,
-0.03819657862186432,
0.017819439992308617,
0.033008791506290436,
0.034239381551742554,
0.021281983703374863,
0.028810305520892143,
-0.019677389413118362,
0.01020063366740942,
0.013234884478151798,
-0.02071494795382023,
-0.02642151154577732,
-0.005046025849878788,
0.01281262282282114,
-0.03937891125679016,
0.022235089913010597,
-0.0015834809746593237,
-0.01538238674402237,
0.020135845988988876,
-0.002411415334790945,
-0.03235730156302452,
0.01669742912054062,
-0.027169518172740936,
-0.012143037281930447,
0.012118907645344734,
-0.008801138028502464,
0.016311362385749817,
0.006502828560769558,
-0.007636902388185263,
-0.010254924185574055,
0.006273600738495588,
-0.0307406447827816,
0.010134277865290642,
-0.04251570999622345,
-0.023538067936897278,
0.013041851110756397,
0.01679394766688347,
-0.006701894570142031,
-0.036748822778463364,
-0.011545838788151741,
-0.03971672058105469,
-0.0031307681929320097,
-0.017722921445965767,
-0.0016061021015048027,
0.04454256594181061,
-0.004967606160789728,
-0.00975424237549305,
-0.02048571966588497,
-0.011871582828462124,
-0.02914811484515667,
-0.010387634858489037,
0.00910275336354971,
-0.020775269716978073,
-0.04077840596437454,
0.017759116366505623,
0.014598186127841473,
-0.00711209187284112,
0.027772748842835426,
0.017312726005911827,
-0.024901369586586952,
0.006047389470040798,
0.0033780927769839764,
0.002076622098684311,
-0.018856996670365334,
0.029727216809988022,
-0.03346724808216095,
0.008909719996154308,
0.014115601778030396,
0.03892045468091965,
-0.03242969140410423,
0.023791424930095673,
0.04531470313668251,
-0.02059430070221424,
0.016009746119379997,
0.010550507344305515,
0.015153158456087112,
-0.03286401554942131,
-0.0072568668983876705,
-0.0186760276556015,
-0.005009832326322794,
0.006575216073542833,
-0.007673096377402544,
0.0004524231480900198,
0.008409038186073303,
0.019436098635196686,
-0.007498159538954496,
0.005326528567820787,
-0.04632812738418579,
-0.01024889200925827,
-0.02632499486207962,
0.0050611067563295364,
0.03216426819562912,
-0.03004089556634426,
-0.004729330074042082,
0.036531660705804825,
0.0023480760864913464,
0.008674459531903267,
0.019134482368826866,
-0.002738668117672205,
-0.029461795464158058,
0.0009696935885585845,
0.038727421313524246,
0.0020193152595311403,
0.015104900114238262,
0.006526957731693983,
-0.00510031683370471,
0.006828573066741228,
-0.01669742912054062,
-0.02411716990172863,
0.019255127757787704,
0.04784826934337616,
-0.02038920298218727,
-0.00766706420108676,
-0.010864187963306904,
0.009452627040445805,
-0.013427918776869774,
0.005374786909669638,
0.0836801826953888,
-0.03496326133608818,
-0.0036555789411067963,
0.027869265526533127,
-0.007226705551147461,
-0.020546043291687965,
0.016251038759946823,
-0.020437460392713547,
0.02714538760483265,
-0.023067547008395195,
0.013488241471350193,
-0.012836752459406853,
0.03054760955274105,
0.010858154855668545,
0.019351646304130554,
-0.015840841457247734,
0.015056641772389412,
0.05318083241581917,
-0.0026089735329151154,
-0.00023563705326523632,
0.013174561783671379,
0.01989455334842205,
0.00454534450545907,
0.01492393109947443,
-0.0016935706371441483,
0.008933848701417446,
-0.019725648686289787,
-0.04109208658337593,
-0.023743165656924248,
0.007226705551147461,
0.03848612681031227,
0.021487083286046982,
0.030475221574306488,
-0.04985099658370018,
0.012559265829622746,
-0.0012230505235493183,
-0.0003973783168476075,
-0.001075258944183588,
-0.022488446906208992,
0.040754277259111404,
0.027796877548098564,
0.014477540738880634,
0.010218730196356773,
-0.010158407501876354,
0.03185058757662773,
0.024672141298651695,
-0.05839274451136589,
0.014441346749663353,
0.029292890802025795,
0.008481426164507866,
0.0337567999958992,
0.02231954224407673,
0.02221095934510231,
0.0008452772162854671,
-0.013958761468529701,
-0.008976074866950512,
0.016130393370985985,
-0.006418376229703426,
0.0032152205239981413,
-0.037327926605939865,
-0.00009241684892913327,
-0.00833665020763874,
0.0033720603678375483,
-0.023248516023159027,
0.010520345531404018
] | 2024-07-08 | 1 | 38972151 | [
"activated T cell responses",
"Tumor-infiltrating T cell subtypes",
"Reduced CD8",
"distinct contributions",
"other chemicals",
"CCA",
"cytokines",
"TME",
"Cholangiocarcinoma",
"the tumor microenvironment",
"immunosuppressors",
"a significant portion",
"the immune system",
"they"
] | [
"Cholangiocarcinoma",
"Immunotherapy",
"Molecular pathogenesis",
"Oncological prognosis",
"Tumor-infiltrating lymphocytes"
] | 0 | 10.1016/j.biopha.2024.117080 | [
"Hua",
"Gu",
"Jin",
"Zhang",
"Liu",
"Yang"
] | [
"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, China. Electronic address: [email protected].",
"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, China. Electronic address: [email protected].",
"Department of Gastroenterology, Affiliated Hangzhou First People's Hospital. School of Medicine, Westlake University, Hangzhou, Zhejiang, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, Zhejiang, China.",
"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, China; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital. School of Medicine, Westlake University, Hangzhou, Zhejiang, China; Hangzhou Institute of Digestive Diseases, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research, Hangzhou, Zhejiang 310003, China. Electronic address: [email protected].",
"Department of Gastroenterology, Affiliated Hangzhou First People's Hospital. School of Medicine, Westlake University, Hangzhou, Zhejiang, China; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, Zhejiang, China. Electronic address: [email protected].",
"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, China; Department of Gastroenterology, Affiliated Hangzhou First People's Hospital. School of Medicine, Westlake University, Hangzhou, Zhejiang, China; Hangzhou Institute of Digestive Diseases, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research, Hangzhou, Zhejiang 310003, China. Electronic address: [email protected]."
] | [
"38972151"
] | [] | 11.069218 | 4.193807 |
38971152 | 754 | Early rhombic lip Protogenin | We identify a population of Protogenin-positive (PRTG | [
-0.010896723717451096,
-0.01566917449235916,
0.054072845727205276,
0.0319657139480114,
-0.02454190142452717,
-0.01599779538810253,
-0.01756620593369007,
0.029934249818325043,
-0.02233118936419487,
-0.04015132784843445,
-0.0017999386182054877,
0.009574777446687222,
0.06058548763394356,
-0.012308293953537941,
0.03100973181426525,
-0.03686513379216194,
-0.01610235497355461,
-0.011875113472342491,
-0.06494716554880142,
0.05717979371547699,
0.06865160167217255,
0.010702540166676044,
0.006329659838229418,
-0.020732903853058815,
-0.020777715370059013,
0.02660324238240719,
-0.009037036448717117,
-0.010523293167352676,
0.0006334327626973391,
-0.006643341854214668,
-0.005018915981054306,
-0.03396730497479439,
-0.0084246089681983,
-0.02911270037293434,
-0.016938840970396996,
-0.010747351683676243,
0.016923904418945312,
0.047171834856271744,
-0.03680538386106491,
0.057807158678770065,
0.04272053390741348,
-0.026364246383309364,
-0.037044379860162735,
0.0084246089681983,
0.011942331679165363,
0.035909149795770645,
0.022032443434000015,
-0.03931484371423721,
0.0024627791717648506,
-0.026752615347504616,
-0.03235408291220665,
-0.004570798482745886,
-0.047619953751564026,
0.013861767947673798,
-0.04137618467211723,
0.015519802458584309,
-0.015549677424132824,
-0.0031666969880461693,
-0.03441542387008667,
0.020389346405863762,
0.013316558673977852,
0.003441168926656246,
0.053953345865011215,
-0.02531863935291767,
0.03214496374130249,
0.007700152229517698,
-0.07235603779554367,
0.006415548734366894,
0.035102538764476776,
-0.005261646583676338,
0.0022928679827600718,
-0.040898192673921585,
-0.006120538339018822,
-0.033250316977500916,
0.011778022162616253,
0.0336984358727932,
0.011225343681871891,
0.0336984358727932,
0.000632499170023948,
0.0007856059819459915,
0.018402691930532455,
0.00020538718672469258,
-0.019149554893374443,
-0.008992224931716919,
-0.025109518319368362,
-0.036775510758161545,
0.014108233153820038,
-0.026050563901662827,
-0.033788058906793594,
0.008320048451423645,
0.0004481174983084202,
-0.02612525038421154,
-0.028096968308091164,
0.03342956677079201,
-0.024960145354270935,
-0.026797426864504814,
0.005074930842965841,
0.014302416704595089,
0.02124076895415783,
0.02569206990301609,
0.016445912420749664,
-0.009806305170059204,
0.01048594992607832,
-0.029247134923934937,
0.021046586334705353,
0.02808202989399433,
0.02043415792286396,
0.03859785571694374,
-0.029082825407385826,
0.020837463438510895,
0.06118297576904297,
0.015280806459486485,
-0.01259957067668438,
0.05365460366010666,
-0.000290576193947345,
0.004376614466309547,
-0.01583348587155342,
-0.0586436428129673,
0.05278824269771576,
0.041704803705215454,
-0.01967235840857029,
0.03208521381020546,
0.019642483443021774,
-0.053803976625204086,
0.005071196239441633,
-0.03599877282977104,
-0.004033057484775782,
-0.01023948471993208,
-0.000871495169121772,
-0.026633117347955704,
0.025707008317112923,
-0.02194282039999962,
-0.0013882307102903724,
0.039643462747335434,
-0.02183825895190239,
0.021285582333803177,
0.02466139942407608,
0.021285582333803177,
-0.015034342184662819,
-0.02909776382148266,
-0.035640276968479156,
-0.02270461991429329,
0.000997995026409626,
0.03931484371423721,
0.0002450642641633749,
-0.07026482373476028,
-0.05909176170825958,
0.020419221371412277,
0.013839362189173698,
0.06966733187437057,
-0.03142797574400902,
0.024362655356526375,
-0.0003099479363299906,
0.011202937923371792,
-0.03214496374130249,
-0.03342956677079201,
0.013757207430899143,
0.03441542387008667,
-0.04292965680360794,
-0.011404590681195259,
0.010777225717902184,
-0.003002387238666415,
-0.0001063112067640759,
0.014130638912320137,
-0.007218426093459129,
0.04624572768807411,
-0.008476889692246914,
-0.027678724378347397,
-0.07480575144290924,
0.031188977882266045,
-0.019358675926923752,
-0.00330673367716372,
-0.07641897350549698,
0.015639301389455795,
-0.03432580083608627,
0.015385367907583714,
-0.039434339851140976,
0.038567978888750076,
-0.0284554623067379,
-0.0818561315536499,
0.00016325947945006192,
0.06025686860084534,
0.042899783700704575,
-0.01583348587155342,
0.04379601776599884,
0.022674744948744774,
0.016162104904651642,
-0.026423996314406395,
0.0057284352369606495,
0.056552428752183914,
0.04633535072207451,
-0.002895959420129657,
0.059689249843358994,
-0.0037361797876656055,
-0.010777225717902184,
-0.09440342336893082,
0.063752181828022,
0.03626764193177223,
-0.030710985884070396,
-0.007954085245728493,
-0.008880195207893848,
-0.007446219213306904,
-0.008715885691344738,
-0.020777715370059013,
-0.007341658230870962,
-0.027618976309895515,
0.022734494879841805,
-0.02823140285909176,
-0.0003433233650866896,
-0.00600477447733283,
0.023212486878037453,
0.01235310547053814,
0.029247134923934937,
0.0012790020555257797,
0.015355492942035198,
-0.004899417981505394,
-0.036775510758161545,
0.05849426984786987,
0.050159286707639694,
0.001638429588638246,
-0.04015132784843445,
0.017640892416238785,
0.03062136285007,
0.06954783946275711,
0.027992406859993935,
0.026648053899407387,
0.03307107090950012,
-0.0012472603702917695,
0.00602718023583293,
-0.07803219556808472,
-0.040838442742824554,
0.013555554673075676,
0.004033057484775782,
-0.047829076647758484,
-0.02488545887172222,
0.010687602683901787,
0.012674257159233093,
0.022555246949195862,
0.017820138484239578,
-0.11848226934671402,
0.011695866473019123,
0.02006072737276554,
0.022794242948293686,
0.019851606339216232,
0.0018624883377924562,
0.004623078741133213,
0.0020295989234000444,
-0.01197967492043972,
0.00012113176489947364,
-0.02991931140422821,
-0.025886254385113716,
0.012958064675331116,
0.04699258878827095,
-0.007886867970228195,
-0.026110313832759857,
0.03289182484149933,
-0.022480562329292297,
-0.003887419356033206,
-0.033847808837890625,
-0.007617997471243143,
-0.00421230448409915,
-0.02406390942633152,
-0.046902965754270554,
-0.0189703069627285,
0.009836179204285145,
0.01837281696498394,
0.017805201932787895,
-0.028813956305384636,
-0.0071848174557089806,
0.012420323677361012,
-0.00973161868751049,
-0.00538114458322525,
0.037910740822553635,
0.004115212243050337,
-0.06542515754699707,
0.05419234186410904,
0.02228637784719467,
0.031129229813814163,
-0.057269416749477386,
-0.021390141919255257,
-0.06656038761138916,
0.011972205713391304,
0.04388564079999924,
0.01489990670233965,
-0.017058338969945908,
0.015788672491908073,
0.012801223434507847,
-0.0020650748629122972,
-0.013368838466703892,
0.009880990721285343,
0.035640276968479156,
-0.011262686923146248,
0.04415450990200043,
-0.005239240359514952,
0.029142575338482857,
0.013152249157428741,
0.017625955864787102,
-0.02569206990301609,
-0.014347229152917862,
0.004077869467437267,
0.00451104948297143,
-0.03399718180298805,
-0.012883378192782402,
-0.007842056453227997,
0.02010553888976574,
0.02737998031079769,
-0.02336185984313488,
-0.021449891850352287,
-0.04080856591463089,
0.018193570896983147,
-0.015430179424583912,
-0.00616534985601902,
0.04006170481443405,
0.008798040449619293,
0.013914048671722412,
0.003999448847025633,
0.005369941238313913,
0.03728337585926056,
-0.012980470433831215,
0.002046403242275119,
-0.05706029385328293,
-0.0015889499336481094,
0.020284784957766533,
0.008626261726021767,
-0.018567001447081566,
-0.014511538669466972,
-0.03199559077620506,
-0.0447818748652935,
0.05499895662069321,
-0.013921516947448254,
0.03181634098291397,
-0.015221057459712029,
0.056821297854185104,
-0.018342943862080574,
-0.01599779538810253,
-0.012711599469184875,
0.017327209934592247,
0.03175659477710724,
0.004092806484550238,
-0.032383959740400314,
-0.06697862595319748,
0.00004320716470829211,
0.012607038952410221,
0.011322435922920704,
0.006471563596278429,
0.019552860409021378,
0.01870143786072731,
0.0006469696527346969,
0.020464032888412476,
0.01504181046038866,
0.0414060577750206,
0.07773344963788986,
0.03429592773318291,
0.00479485746473074,
-0.00061802874552086,
-0.07271452993154526,
0.06853210180997849,
0.027305293828248978,
-0.029993997886776924,
0.025049768388271332,
-0.0473809577524662,
0.028470398858189583,
-0.03782111778855324,
0.011397121474146843,
-0.004832200240343809,
0.04358689486980438,
-0.05759803578257561,
0.033310066908597946,
0.026095375418663025,
-0.06697862595319748,
-0.030651237815618515,
0.02150963991880417,
0.001928772428072989,
0.040509823709726334,
-0.04424413666129112,
0.03241383284330368,
0.003797795856371522,
0.009963145479559898,
-0.009081847965717316,
0.0003514921700116247,
0.008738291449844837,
0.029949186369776726,
0.06524591147899628,
-0.063752181828022,
0.028007343411445618,
-0.0014311752747744322,
0.012129046954214573,
0.005586531478911638,
-0.09308893978595734,
0.015758799389004707,
0.0041600242257118225,
-0.026842238381505013,
0.011143188923597336,
-0.03982270881533623,
-0.03483366593718529,
-0.01317465491592884,
-0.0594203807413578,
0.006482766475528479,
0.05057752877473831,
0.023436546325683594,
-0.03961358591914177,
-0.03250345587730408,
-0.011897520162165165,
0.025184202939271927,
-0.03408680483698845,
-0.01106103416532278,
-0.03208521381020546,
0.05404297262430191,
0.03429592773318291,
-0.014003671705722809,
-0.032981447875499725,
-0.020717965438961983,
0.02666299231350422,
0.026155125349760056,
0.018835872411727905,
-0.022629933431744576,
-0.003073339117690921,
0.024526964873075485,
-0.04068906977772713,
0.012278419919312,
0.006258707959204912,
-0.03811986371874809,
-0.0219577569514513,
-0.010844443924725056,
-0.005153351463377476,
-0.006583592854440212,
0.010568104684352875,
-0.020120475441217422,
-0.04245166480541229,
-0.030322616919875145,
0.013219466432929039,
0.02779822237789631,
-0.019313864409923553,
-0.02829115092754364,
-0.003762319916859269,
-0.01717783696949482,
0.04552873969078064,
0.006415548734366894,
0.029530944302678108,
0.006665748078376055,
-0.026573367416858673,
-0.019283989444375038,
0.014675848186016083,
-0.013002876192331314,
-0.01021707896143198,
-0.011994611471891403,
0.0001408536045346409,
-0.0040704007260501385,
-0.02385478839278221,
-0.005974899977445602,
-0.024258093908429146,
0.0431387796998024,
0.038717351853847504,
-0.018328005447983742,
-0.0022237831726670265,
-0.015489928424358368,
-0.0036390875466167927,
0.030920106917619705,
0.05210112780332565,
-0.00570602947846055,
0.043825890868902206,
-0.01138218492269516,
-0.01723758690059185,
-0.006385674234479666,
-0.03014337085187435,
-0.013615303672850132,
-0.049561794847249985,
0.009903396479785442,
0.007976491935551167,
-0.042242541909217834,
-0.007468624971807003,
-0.01571398787200451,
-0.036656010895967484,
0.027589101344347,
0.006269910838454962,
-0.009388062171638012,
0.01653553545475006,
0.027126045897603035,
0.009612120687961578,
-0.00948515348136425,
-0.007532108575105667,
-0.025826506316661835,
0.025079643353819847,
-0.0033646156080067158,
0.015743860974907875,
0.09004174172878265,
0.006053320597857237,
0.037582121789455414,
0.008596387691795826,
-0.009559839963912964,
0.0014759870246052742,
-0.015221057459712029,
0.004638016223907471,
-0.020135413855314255,
0.01216639019548893,
-0.03656638786196709,
0.053684476763010025,
0.008693479932844639,
-0.007311783730983734,
-0.012831097468733788,
0.004451300483196974,
0.005403550341725349,
-0.011501682922244072,
0.0397629588842392,
0.04298940673470497,
0.037582121789455414,
0.0177155788987875,
-0.0008822313393466175,
-0.01804419793188572,
0.019164491444826126,
-0.003969574347138405,
0.016655033454298973,
-0.015639301389455795,
-0.011285092681646347,
-0.0013900978956371546,
0.021330393850803375,
-0.01761101745069027,
0.005952494218945503,
-0.029306884855031967,
0.006497703958302736,
0.009477685205638409,
-0.00210055080242455,
-0.02791772037744522,
0.03662613779306412,
-0.001556274713948369,
-0.04812781885266304,
-0.026005752384662628,
-0.05945025384426117,
-0.008902600966393948,
-0.024243157356977463,
0.0064640948548913,
0.007308049593120813,
0.01455635018646717,
-0.0013574225595220923,
-0.034714169800281525,
-0.0024030301719903946,
-0.04334789887070656,
0.0032861949875950813,
-0.013563022948801517,
-0.008753228932619095,
-0.004966635722666979,
0.0042496477253735065,
-0.020135413855314255,
-0.01454888191074133,
0.010418731719255447,
0.022943615913391113,
0.014347229152917862,
-0.03250345587730408,
-0.005620140582323074,
0.030232993885874748,
0.053624726831912994,
-0.0075171710923314095,
0.03516228497028351,
-0.027454664930701256,
-0.012980470433831215,
-0.03713400289416313,
-0.009791367687284946,
0.0010297367116436362,
0.02428796887397766,
0.019552860409021378,
0.005627608858048916,
0.004339271225035191,
0.011023690924048424,
-0.04254128783941269,
0.015848422423005104,
0.07032456994056702,
0.012719068676233292,
-0.0047052339650690556,
-0.005885276477783918,
0.031517598778009415,
-0.03247358277440071,
0.008850320242345333,
-0.01626666449010372,
0.008641199208796024,
0.04448313266038895,
-0.015400304459035397,
-0.005123476963490248,
-0.007016773335635662,
0.00037809915374964476,
-0.019956165924668312,
-0.004951698239892721,
0.0027876642998307943,
0.03928496688604355,
0.01262944471091032,
-0.024198345839977264,
-0.062198709696531296,
-0.001124961650930345,
-0.025273827835917473,
0.016341350972652435,
0.017894824966788292,
0.023376796394586563,
-0.0019250380573794246,
0.019537923857569695,
-0.009111722931265831,
0.0006315656355582178,
-0.01962754689157009,
-0.02487052232027054,
0.012495010159909725,
-0.06793460994958878,
-0.0035924087278544903,
0.02965044230222702,
0.013122374191880226,
-0.00920881424099207,
-0.01062785368412733,
0.011770552955567837,
0.025333575904369354,
-0.0038164674770087004,
0.0002083046274492517,
0.02357098087668419,
-0.0020986837334930897,
-0.025004956871271133,
0.0207030288875103,
-0.015460053458809853,
0.02059846743941307,
-0.010194673202931881,
-0.00929843820631504,
-0.028918515890836716,
0.007543311454355717,
0.017491519451141357,
0.012285888195037842,
-0.005328863859176636,
0.006647076457738876,
0.004596938844770193,
-0.022405875846743584,
-0.022629933431744576,
0.0032115087378770113,
0.018716374412178993,
0.0027745941188186407,
-0.004025588743388653,
0.00902209896594286,
-0.003073339117690921,
-0.04385576769709587,
0.002367554232478142,
0.03220470994710922,
0.017625955864787102,
-0.016520598903298378,
0.007528373971581459,
-0.003894887864589691,
-0.019418425858020782,
-0.034116677939891815,
0.015594488941133022,
0.04379601776599884,
-0.016057543456554413,
-0.053415607661008835,
0.018895622342824936,
-0.0017261860193684697,
-0.010889255441725254,
0.027872908860445023,
0.028365837410092354,
-0.029456257820129395,
0.003732445416972041,
-0.00973161868751049,
0.033041197806596756,
-0.006493969354778528,
-0.015079153701663017,
-0.010306702926754951,
-0.03570002689957619,
0.020284784957766533,
-0.004230976104736328,
0.034983038902282715,
-0.052877865731716156,
0.00011395488400012255,
0.0037567184772342443,
0.010426200926303864,
0.0012547289952635765,
0.03776136785745621,
0.0037119067274034023,
0.05165301263332367,
-0.042302291840314865,
-0.002884756540879607,
0.06829310953617096,
-0.021151145920157433,
0.06079460680484772,
-0.014347229152917862,
0.026857174932956696,
0.027335166931152344,
-0.016834281384944916,
-0.022047381848096848,
-0.007588122971355915,
0.003513988107442856,
0.014018609188497066,
0.01903005689382553,
-0.0422724187374115,
0.008454483933746815,
-0.03689500689506531,
-0.005616405978798866,
0.022092193365097046,
-0.006367003079503775,
-0.0029314353596419096,
0.004679093603044748,
-0.014862563461065292,
-0.0071549429558217525,
0.015295743942260742,
0.003500917926430702,
0.004025588743388653,
-0.031726717948913574,
-0.024482153356075287,
-0.008260299451649189,
-0.0009475817787460983,
-0.038836851716041565,
0.030770735815167427,
0.01571398787200451,
0.010732414200901985,
-0.03354906290769577,
-0.02243574894964695,
0.013727332465350628,
-0.028903579339385033,
0.007341658230870962,
0.027170857414603233,
-0.0011585704050958157,
-0.0011753748403862119,
0.054072845727205276,
-0.031846217811107635,
0.016923904418945312,
0.0025486683007329702,
-0.024586712941527367,
-0.034714169800281525,
0.023227423429489136,
-0.008768165484070778,
0.008066114969551563,
0.01366011518985033,
0.02325729839503765,
0.02720073238015175,
-0.037432748824357986,
0.020956961438059807,
-0.01512396614998579,
-0.019224241375923157,
0.03133834898471832,
-0.028141779825091362,
0.007894336245954037,
0.02921726182103157,
-0.03755224868655205,
0.0018428831826895475,
0.014937249943614006,
0.014451789669692516,
0.03089023381471634,
0.022256502881646156,
0.012704131193459034,
-0.019747044891119003,
0.010232016444206238,
0.010874317958950996,
-0.0327424518764019,
-0.025169266387820244,
0.0028511476702988148,
0.016610221937298775,
0.037970490753650665,
-0.0018811599584296346,
0.025049768388271332,
0.012562227435410023,
-0.01625172793865204,
-0.012069297954440117,
0.014212793670594692,
-0.006296050734817982,
-0.02797747030854225,
0.01917942985892296,
-0.0033347411081194878,
0.02633437141776085,
0.00015835819067433476,
-0.030710985884070396,
0.0067292312160134315,
0.008140801452100277,
0.02103164792060852,
0.04018120467662811,
0.012024486437439919,
0.013241872191429138,
0.03405693173408508,
-0.0004096073971595615,
-0.004488643724471331,
0.017551269382238388,
-0.02000097744166851,
-0.016610221937298775,
0.023212486878037453,
0.04206329584121704,
-0.0010820170864462852,
-0.0168044064193964,
-0.020195161923766136,
-0.028171652927994728,
-0.005496907979249954,
0.016610221937298775,
0.0500696636736393,
-0.02439253032207489,
0.016236791387200356,
0.016864154487848282,
-0.01571398787200451,
-0.0037884600460529327,
-0.005926353856921196,
0.018447503447532654,
0.012719068676233292,
-0.008641199208796024,
0.008484357967972755,
0.059061888605356216,
0.006968227215111256,
-0.0014759870246052742,
0.033250316977500916,
0.009686807170510292,
0.032443705946207047,
0.003114416729658842,
-0.07044406980276108,
-0.02835090085864067,
-0.002963176928460598,
-0.007461156230419874,
-0.020747840404510498,
0.019761981442570686,
0.055745817720890045,
-0.0037959287874400616,
0.0044662379659712315,
-0.0008602922316640615,
0.02905295230448246,
-0.024258093908429146,
0.006310988217592239,
-0.021375205367803574,
0.0016262930585071445,
-0.02086733840405941,
-0.0043952856212854385,
-0.014601161703467369,
0.0011949799954891205,
0.0035942757967859507,
-0.01489990670233965,
-0.004328068345785141,
0.016565410420298576,
0.03268270194530487,
-0.05210112780332565,
-0.014451789669692516,
0.0016739056445658207,
-0.03262295573949814,
0.015221057459712029,
0.01664009690284729,
-0.00813333224505186,
0.005832996219396591,
0.0061578815802931786,
0.01289831567555666,
-0.006721762474626303,
-0.023839851841330528,
0.006531312596052885,
-0.017103150486946106,
0.013346432708203793,
0.009649463929235935,
-0.020523780956864357,
-0.0034523720387369394,
0.012196265161037445,
-0.012285888195037842,
0.028201527893543243,
0.016834281384944916,
-0.014892438426613808,
-0.0004623545682989061,
0.019522985443472862,
0.027185795828700066,
0.016819342970848083,
-0.012920721434056759,
0.023078052327036858,
0.016132229939103127,
-0.012039423920214176,
0.008992224931716919,
-0.021659012883901596,
-0.018656624481081963,
-0.03199559077620506,
0.03570002689957619,
-0.010635321959853172,
0.002591612981632352,
0.06363268196582794,
-0.01701352745294571,
-0.04146580770611763,
-0.007420078851282597,
-0.02064327895641327,
0.02515432983636856,
0.0013042086502537131,
0.002673767739906907,
0.01903005689382553,
0.03399718180298805,
-0.026379182934761047,
0.02835090085864067,
-0.02628955990076065,
0.00018566535436548293,
0.007132536731660366,
-0.04340764880180359,
-0.03638714179396629,
-0.018462441861629486,
-0.04520012065768242,
0.018133820965886116,
-0.004720170982182026,
-0.02179344743490219,
0.03626764193177223,
-0.0072109573520720005,
0.021778510883450508,
-0.0207030288875103,
0.03952396288514137,
-0.024526964873075485,
0.028545085340738297,
-0.031726717948913574,
-0.022361064329743385,
0.02839571237564087,
0.016819342970848083,
-0.027708599343895912,
-0.03931484371423721,
0.0035905414260923862,
0.04812781885266304,
-0.004884480964392424,
0.019552860409021378,
0.012584633193910122,
-0.01783507689833641,
-0.04711208865046501,
-0.01565423794090748,
-0.032055336982011795,
0.0569109246134758,
-0.005160819739103317,
-0.020792651921510696,
0.006740434095263481,
0.04107743874192238,
0.02406390942633152,
0.004854606464505196,
-0.0014983928995206952,
0.01094900444149971,
-0.031039604917168617,
0.029456257820129395,
-0.021166084334254265,
-0.015094091184437275,
-0.008021303452551365,
0.05177250877022743,
0.02985956333577633,
0.020613405853509903,
-0.008163207210600376,
0.010993815958499908,
-0.0026382918003946543,
-0.01841762848198414,
0.04182429984211922,
0.016938840970396996,
0.01469078566879034,
0.016789469867944717,
-0.010530761443078518,
-0.011098376475274563,
-0.009380592964589596,
0.017043402418494225,
-0.0319657139480114,
0.011830301955342293,
-0.016460848972201347,
-0.03039730340242386,
-0.028933454304933548,
-0.014160512946546078,
-0.006381940096616745,
-0.0006941153551451862,
0.026080438867211342,
-0.006755371578037739,
-0.023929474875330925,
-0.04812781885266304,
0.02053871937096119,
-0.005836730357259512,
-0.0032301803585141897,
0.028156716376543045,
-0.007924211211502552,
0.020180225372314453,
0.009858584962785244,
-0.017267461866140366,
0.04194379970431328,
0.024975081905722618,
0.04286990687251091,
-0.03160722181200981,
-0.012502478435635567,
0.0007753366371616721,
0.03811986371874809,
-0.03322044387459755,
-0.030651237815618515,
-0.02016528695821762,
-0.02206231839954853,
0.007169879972934723,
0.015228526666760445,
-0.00007766202907077968,
-0.0024777164217084646,
-0.014593693427741528,
-0.05464046075940132,
0.024243157356977463,
0.0288886409252882,
-0.019582735374569893,
0.029142575338482857,
0.014309885911643505,
0.02552776038646698,
-0.01566917449235916,
0.037970490753650665,
0.0023414138704538345,
0.045229993760585785,
0.023122863844037056,
0.032712578773498535,
0.05750841274857521,
-0.02303323894739151,
-0.00248518493026495,
0.002970645669847727,
0.019582735374569893,
0.006318456958979368,
-0.007730026729404926,
0.0011753748403862119,
0.007266972213983536,
0.02233118936419487,
0.03441542387008667,
-0.005284052342176437,
0.013368838466703892,
0.031905967742204666,
-0.01885080896317959,
-0.01168092992156744,
-0.00643795495852828,
0.029501069337129593,
0.028216466307640076,
-0.0421827957034111,
0.004047994967550039,
0.013182123191654682,
0.05272849276661873,
-0.0038836849853396416,
-0.05732916668057442,
-0.013167185708880424,
0.011314966715872288,
-0.016938840970396996,
0.031846217811107635,
0.03121885284781456,
0.03832898288965225,
-0.0016356288688257337,
-0.03662613779306412,
0.011180532164871693,
0.009253626689314842,
-0.010373920202255249,
0.0062437704764306545,
-0.026155125349760056,
0.004903152585029602,
0.004697765223681927,
0.015228526666760445,
0.01186764519661665,
-0.011090908199548721,
0.011322435922920704,
-0.020359471440315247,
0.011001285165548325,
0.0011146923061460257,
0.007483562454581261,
-0.02325729839503765,
0.03587927296757698,
0.01614716649055481,
-0.012987938709557056,
0.011038627475500107,
0.016191979870200157,
-0.03779124468564987,
-0.02493027038872242,
-0.02004578895866871,
-0.022525373846292496,
0.00929843820631504,
-0.00046725585707463324,
0.04281016066670418,
-0.02227143943309784,
0.04744070768356323,
-0.04475200176239014,
-0.02573688142001629,
-0.016819342970848083,
-0.019806792959570885,
-0.015168777666985989,
-0.02406390942633152,
0.008581450209021568,
0.027783285826444626,
0.000476591638289392,
0.00018939966685138643,
-0.016714783385396004,
-0.010695070959627628,
-0.021748635917901993,
-0.054281968623399734,
-0.022151941433548927,
0.032055336982011795,
-0.0024011628702282906,
0.01669984497129917,
-0.01696871593594551,
0.01885080896317959,
0.0012183195212855935,
0.016655033454298973,
-0.009806305170059204,
-0.013943922705948353,
-0.015026873908936977,
-0.022405875846743584,
-0.012592101469635963,
-0.007677746471017599,
-0.02086733840405941,
0.03014337085187435,
-0.021987631916999817,
0.009470216929912567,
0.024586712941527367,
-0.03051680140197277,
0.002979981480166316,
-0.02243574894964695,
0.04681334272027016,
-0.0007795377168804407,
-0.0057321698404848576,
-0.013286683708429337,
0.02097189985215664,
0.025975877419114113,
0.03581952676177025,
0.01783507689833641,
-0.0068860724568367004,
-0.012748942710459232,
-0.02785797230899334,
-0.006553718354552984,
-0.014840157702565193,
-0.03587927296757698,
0.018298130482435226,
0.039105720818042755,
-0.01583348587155342,
0.04926305264234543,
0.026916924864053726,
-0.005635077599436045,
-0.005362472962588072,
0.014772940427064896,
-0.010986347682774067,
-0.011456870473921299,
-0.03045705333352089,
0.003373951418325305,
-0.02150963991880417,
-0.0011408324353396893,
-0.00555665697902441,
0.006710559595376253,
0.0064640948548913,
0.0012164523359388113,
0.008753228932619095,
-0.016236791387200356,
0.024556839838624,
-0.0016253595240414143,
0.013338964432477951,
-0.03925509378314018,
0.0003024793113581836,
0.02606550231575966,
0.017625955864787102,
-0.018462441861629486,
0.006210161838680506,
-0.010583042167127132,
0.03713400289416313,
-0.015243464149534702,
0.014601161703467369,
0.016356289386749268,
-0.010710008442401886,
-0.00044041548972018063,
0.010007957927882671,
0.009059442207217216,
0.01787988841533661,
0.020135413855314255,
-0.04773944988846779,
0.008738291449844837,
0.0010866849916055799,
-0.028007343411445618,
-0.017207711935043335,
-0.030277805402874947,
0.002529996680095792,
-0.0037716557271778584,
0.02270461991429329,
0.00961958896368742,
0.006053320597857237,
0.007315518334507942,
0.018835872411727905,
0.08866751939058304,
0.00026326903025619686,
0.00632592523470521,
0.010456074960529804,
0.0030359961092472076,
-0.0007632001070305705,
0.028530146926641464,
-0.00602718023583293,
-0.002270461991429329,
0.04245166480541229,
0.00027960664010606706,
0.005810590460896492,
-0.00451104948297143,
0.007931679487228394,
-0.017147963866591454,
-0.0018708906136453152,
-0.02612525038421154,
-0.056074436753988266,
0.028604833409190178,
-0.031188977882266045,
0.025975877419114113,
0.023122863844037056,
0.01005276944488287,
0.028007343411445618,
-0.008902600966393948,
-0.013077562674880028,
0.01610235497355461,
0.0004943296080455184,
0.014720659703016281,
0.006225098855793476,
0.023750226944684982,
-0.02124076895415783,
-0.011188000440597534,
-0.004955432843416929,
0.015863358974456787,
-0.004369145724922419,
-0.00600477447733283,
-0.008984755724668503,
0.020090602338314056,
-0.013219466432929039,
0.0003232514427509159,
-0.0016356288688257337,
0.002888490678742528,
0.010134924203157425,
-0.0011137586552649736,
0.0370742529630661,
0.029172450304031372,
0.01583348587155342,
-0.009410467930138111,
-0.04188404977321625,
-0.04331802576780319,
0.01259957067668438,
-0.009395530447363853,
0.012114109471440315,
0.007308049593120813,
-0.004727639723569155,
0.0035606669262051582,
-0.0004868609830737114,
0.025453073903918266,
-0.0028343431185930967,
-0.0159380454570055,
0.010769757442176342,
-0.019283989444375038,
-0.006986898835748434,
0.008790571242570877,
0.012450197711586952,
0.018283193930983543,
0.014130638912320137,
0.013264277949929237,
0.029993997886776924,
-0.0011128251207992435,
-0.006691887974739075,
0.043049156665802,
0.001221120241098106,
0.0010157329961657524,
0.00017119488620664924,
0.03483366593718529,
-0.0021845728624612093,
0.004316865466535091,
0.027902783825993538,
-0.004118946846574545,
-0.033041197806596756,
0.015094091184437275,
0.0045259869657456875,
-0.03561040386557579,
-0.007274440955370665,
-0.01643097586929798,
-0.004589470103383064,
0.011337372474372387,
0.012024486437439919,
0.013271747156977654,
0.020180225372314453,
-0.03653651475906372,
0.010396325960755348,
-0.030979856848716736,
-0.01929892785847187,
0.008745759725570679,
-0.013831893913447857,
-0.016520598903298378,
0.05532757565379143,
-0.012046892195940018,
0.0013574225595220923,
0.012450197711586952,
0.006479032337665558,
-0.03310094773769379,
0.010142392478883266,
-0.015243464149534702,
-0.04514037072658539,
-0.015519802458584309,
-0.00278392992913723,
0.003344076918438077,
0.00493302708491683,
-0.0018932964885607362,
-0.010612916201353073,
-0.022181816399097443,
0.005205631721764803,
0.008798040449619293,
0.022301314398646355,
0.003995714243501425,
-0.012696662917733192,
0.008618793450295925,
0.003965839743614197,
-0.0006418349803425372,
-0.0008962349966168404,
0.02216687984764576,
-0.018925495445728302,
0.027783285826444626,
-0.01734214648604393,
0.00009575011063134298,
0.009880990721285343,
-0.022047381848096848,
0.0008439546218141913,
0.011860176920890808,
0.00040120520861819386,
0.036506637930870056,
-0.02389959990978241,
-0.02146482840180397,
-0.05213100463151932,
0.0159380454570055,
0.016625158488750458,
0.037313248962163925,
-0.020090602338314056,
-0.007954085245728493,
-0.017147963866591454,
-0.005373675841838121,
0.02894839085638523,
0.00048125951434485614,
-0.02472114935517311,
-0.04292965680360794,
-0.01257716491818428,
-0.016938840970396996,
-0.03988245874643326,
-0.027843033894896507,
0.008544106967747211,
0.0020837464835494757,
0.0031853686086833477,
0.006938352715224028,
-0.02573688142001629,
-0.0007935414323583245,
0.02037440985441208,
-0.007614263333380222,
-0.01729733496904373,
-0.003924762364476919,
-0.01016479916870594,
0.01907486841082573,
0.011778022162616253,
-0.00856651272624731,
-0.0047052339650690556,
0.029142575338482857,
0.03605852276086807,
-0.013936454430222511,
-0.020956961438059807,
-0.005765778478235006,
-0.03516228497028351,
-0.03250345587730408,
-0.015893233940005302,
-0.03895634785294533,
0.04585735872387886,
-0.015908170491456985,
0.03555065393447876,
0.0466042198240757,
-0.010224548168480396,
0.026050563901662827,
-0.014123169705271721,
0.0008056779042817652,
0.021494703367352486,
-0.010844443924725056,
0.0030061216093599796,
-0.0034000915475189686,
-0.002854882040992379,
0.02726048231124878,
-0.012838566675782204,
0.040778692811727524,
0.02573688142001629,
0.006396877579391003,
0.05051777884364128,
0.01637122593820095,
-0.03489341586828232,
-0.028649644926190376,
-0.014220261946320534,
-0.02466139942407608,
0.003655891865491867,
0.04245166480541229,
-0.002800734480842948,
0.00961958896368742,
-0.01547499094158411,
-0.012188795953989029,
0.008305110968649387,
-0.03593902289867401,
-0.01641603745520115,
0.0037268439773470163,
-0.03127860277891159,
0.00003947285222238861,
0.017491519451141357,
0.01664009690284729,
-0.02271955832839012,
-0.00043528081732802093,
0.023451482877135277,
-0.03528178483247757,
0.007976491935551167,
0.02688704989850521,
-0.021987631916999817,
-0.015235994942486286,
-0.056014686822891235,
-0.040300700813531876,
0.02433278039097786,
-0.04074881970882416,
0.011023690924048424,
-0.011643586680293083,
0.03605852276086807,
-0.02802228182554245,
-0.03635726496577263,
-0.013264277949929237,
-0.023750226944684982,
0.005545454099774361,
-0.006841260474175215,
-0.02173369936645031,
-0.028604833409190178,
-0.030800608918070793,
0.015325618907809258,
-0.03083048388361931,
-0.010022894479334354,
0.005033853463828564,
-0.02346641942858696,
-0.042571164667606354,
-0.024482153356075287,
0.015639301389455795,
0.002888490678742528,
-0.033578939735889435,
0.013884173706173897,
0.018671562895178795,
0.015094091184437275,
-0.005422221962362528,
-0.038567978888750076,
-0.024810772389173508,
0.009395530447363853,
0.015967920422554016,
0.001712182303890586,
0.002556137042120099,
-0.027350105345249176,
-0.004940495360642672,
-0.015967920422554016,
0.02487052232027054,
0.012121578678488731,
0.0050973366014659405,
0.034923288971185684,
0.0025075909215956926,
-0.008469420485198498,
0.014720659703016281,
-0.0042757876217365265,
0.023346921429038048,
0.0026831035502254963,
-0.02802228182554245,
0.02660324238240719,
-0.00014097029634285718,
0.03808998689055443,
-0.012726536951959133,
0.014489132910966873,
0.0345647968351841,
0.004230976104736328,
0.012801223434507847,
-0.021061522886157036,
-0.019806792959570885,
-0.011150657199323177,
0.002875420730561018,
0.02633437141776085,
0.0107846949249506,
-0.0024478419218212366,
-0.014377103187143803,
-0.009761492721736431,
0.000040406430343864486,
0.002466513542458415,
0.01127015519887209,
0.0034430362284183502,
0.0004399486933834851,
0.025811567902565002,
0.011180532164871693,
-0.03286195173859596,
-0.023391732946038246,
-0.0028418118599802256,
-0.02861977182328701,
0.008783102966845036,
-0.007812181953340769,
-0.021106334403157234,
0.023272234946489334,
0.03348931297659874,
-0.0005624808254651725,
0.001705647213384509,
-0.00888766348361969,
-0.015803610906004906,
0.049292925745248795,
-0.022853992879390717,
0.010807100683450699,
-0.024810772389173508,
0.010418731719255447,
0.022301314398646355,
-0.015848422423005104,
0.036775510758161545,
0.005750841461122036,
0.02454190142452717,
0.013144779950380325,
0.02080759033560753,
-0.015594488941133022,
0.009515028446912766,
0.06763587146997452,
-0.007502234075218439,
0.03175659477710724,
0.02043415792286396,
0.03094998188316822,
-0.02876914292573929,
0.0009032368543557823,
0.0005059993709437549,
0.05105552077293396,
-0.011598775163292885,
0.027574162930250168,
-0.03835885971784592,
-0.01841762848198414,
0.000774403044488281,
0.026483744382858276,
-0.043557021766901016,
-0.04992029070854187,
0.04388564079999924,
0.011621180921792984,
-0.006019711960107088,
0.018776124343276024,
0.021927883848547935,
-0.023780101910233498,
-0.01032910868525505,
0.02737998031079769,
-0.005489439237862825,
0.00691221235319972,
-0.0006371670751832426,
-0.020449096336960793,
0.016236791387200356,
0.032383959740400314,
-0.037163879722356796,
0.009709212929010391,
-0.01614716649055481,
-0.002046403242275119,
0.014571287669241428,
-0.01474306546151638,
-0.019493112340569496,
-0.0008588918717578053,
-0.03154747188091278,
0.017147963866591454,
-0.02082252688705921,
0.0006432353402487934,
0.012091703712940216,
0.044901374727487564,
0.003403825918212533,
-0.009970614686608315,
0.013787081465125084,
-0.005362472962588072,
-0.024048972874879837,
-0.018985245376825333,
-0.007408875972032547,
-0.014787877909839153,
-0.041973672807216644,
0.0017019129591062665,
0.00856651272624731,
-0.00239742873236537,
0.0017224516486749053,
-0.014182918705046177,
-0.013645177707076073,
-0.011912456713616848,
-0.012360574677586555,
-0.0022816648706793785,
0.01604260690510273,
0.006546250078827143
] | 2024-07-07 | 57 | 38971152 | [
"Protogenin",
"Protogenin-positive (PRTG",
"a population",
"We"
] | [
"brain development",
"brain tumor immunotherapy",
"cancer genomics",
"group 3 medulloblastoma",
"perivascular niche",
"rhombic lip"
] | 0 | 10.1016/j.cell.2024.06.011
10.1038/nature11327
10.1016/j.ccell.2017.05.005
10.1126/science.aax7526
10.1038/s41593-021-00872-y
10.1523/JNEUROSCI.0473-10.2010
10.1007/s00401-021-02355-7
10.1016/j.celrep.2020.107782
10.7554/eLife.62873
10.7554/eLife.42388
10.1073/pnas.0910786107
10.1523/JNEUROSCI.4385-15.2016
10.1038/nature22973
10.1038/nature13379
10.1007/s00401-013-1198-2
10.1016/S0092-8674(00)81079-X
10.1200/JCO.2009.27.4324
10.1038/labinvest.2009.55
10.1038/ncb3543
10.1038/s41583-023-00684-y
10.1016/j.celrep.2013.05.014
10.1007/s00018-022-04314-1
10.1242/dev.003095
10.1002/bdra.20589
10.1038/s41586-022-05208-9
10.1038/s41586-022-05215-w
10.1038/nrc.2017.18
10.1038/nrn3921
10.1038/nmeth762
10.1016/j.expneurol.2015.07.027
10.1016/j.ccr.2014.05.005
10.1016/j.neuron.2011.01.023
10.1093/nar/gkab1038
10.1038/s41593-020-00794-1
10.1016/j.xpro.2021.100617
10.1093/bioinformatics/bts635
10.1186/s13059-014-0550-8
10.1073/pnas.0506580102
10.1101/gr.1239303
10.1371/journal.pone.0013984
10.1016/j.cell.2019.05.031
10.1016/j.jim.2009.06.008
10.1038/ncomms14049
10.1093/bioinformatics/btu638
10.1126/science.aax0249
10.1093/nar/gkz543
10.1093/bioinformatics/btu305
10.1038/nmeth.4463
10.1093/bioinformatics/bts034
10.1371/journal.pone.0012776
10.1038/nbt.4314
10.1038/s41593-019-0491-3
10.1101/pdb.prot4986
10.1038/s41586-019-1158-7
10.3389/fimmu.2022.869825
10.1016/j.virol.2007.01.015
10.1126/science.aad0501 | [
"Visvanathan",
"Saulnier",
"Chen",
"Haldipur",
"Orisme",
"Delaidelli",
"Shin",
"Millman",
"Bryant",
"Abeysundara",
"Wu",
"Hendrikse",
"Patil",
"Bashardanesh",
"Golser",
"Livingston",
"Nakashima",
"Funakoshi",
"Ong",
"Rasnitsyn",
"Aldinger",
"Richman",
"Van Ommeren",
"Lee",
"Ly",
"Vladoiu",
"Kharas",
"Balin",
"Erickson",
"Fong",
"Zhang",
"Suárez",
"Wang",
"Huang",
"Pallota",
"Douglas",
"Haapasalo",
"Razavi",
"Silvestri",
"Sirbu",
"Worme",
"Kameda-Smith",
"Wu",
"Daniels",
"MichaelRaj",
"Bhaduri",
"Schramek",
"Suzuki",
"Garzia",
"Ahmed",
"Kleinman",
"Stein",
"Dirks",
"Dunham",
"Jabado",
"Rich",
"Li",
"Sorensen",
"Wechsler-Reya",
"Weiss",
"Millen",
"Ellison",
"Dimitrov",
"Taylor"
] | [
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Genomics and Development of Childhood Cancers, Institut Curie, PSL University, 75005 Paris, France; INSERM U830, Cancer Heterogeneity Instability and Plasticity, Institut Curie, PSL University, 75005 Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, 75005 Paris, France.",
"Center for Antibody Therapeutics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.",
"Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.",
"St. Jude Children's Research Hospital, Memphis, TN, USA.",
"British Columbia Cancer Agency, Vancouver, BC, Canada.",
"Center for Antibody Therapeutics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.",
"Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.",
"Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.",
"Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.",
"MacFeeters-Hamilton Center for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.",
"Lady Davis Institute, McGill University, Montreal, QC, Canada.",
"Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.",
"Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.",
"Departments of Pediatrics and Neurology. University of Washington, Seattle, WA, USA.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.",
"Department of Neurosurgery, Tampere University Hospital, Tampere, Finland.",
"Assistance Publique Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France.",
"Surgical Pathology Unit, San Camillo Forlanini Hospital, Rome, Italy.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.",
"Division of Experimental Medicine, McGill University, Montreal, QC, Canada.",
"Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA.",
"Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.",
"Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.",
"Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.",
"Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.",
"Cancer Research Program, McGill University Health Centre Research Institute, Montreal, QC, Canada.",
"Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA.",
"Department of Human Genetics, McGill University, Montreal, QC, Canada; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada.",
"Adaptive Oncology, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.",
"British Columbia Children's Hospital, Vancouver, BC, Canada.",
"Departments of Pediatrics and Human Genetics, McGill University, Montreal, QC, Canada; The Research Institute of the McGill University Health Center, Montreal, QC, Canada.",
"Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.",
"Center for Antibody Therapeutics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.",
"British Columbia Cancer Agency, Vancouver, BC, Canada.",
"Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.",
"Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.",
"Department of Pediatrics, University of Washington, Seattle, USA.",
"St. Jude Children's Research Hospital, Memphis, TN, USA.",
"Center for Antibody Therapeutics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: [email protected].",
"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Texas Children's Hospital, Houston, TX, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA; Department of Surgery, University of Toronto, Toronto, ON, Canada. Electronic address: [email protected]."
] | [
"38971152",
"22832581",
"28609654",
"31624095",
"34140698",
"20335479",
"34347142",
"32579914",
"33554859",
"30735127",
"20498066",
"27581449",
"28726821",
"25043047",
"24174164",
"8620534",
"20823417",
"19488036",
"28561054",
"36941369",
"23770240",
"35589983",
"17728348",
"19441098",
"36131015",
"36131014",
"28386091",
"26174708",
"15908920",
"26247808",
"24954133",
"21382550",
"34723319",
"33723434",
"34095859",
"23104886",
"25516281",
"16199517",
"14597658",
"21085593",
"31178118",
"19567251",
"28091601",
"25260700",
"31974247",
"31226206",
"24794931",
"28991892",
"22257669",
"20927193",
"30531897",
"31551601",
"21356829",
"31043743",
"35464476",
"17306322",
"27124452"
] | [] | 32.934521 | 7.552216 |
38969928 | 755 | Correction to: New CEACAM-targeting 2A3 single-domain antibody-based chimeric antigen receptor T-cells produce anticancer effects in vitro and in vivo. | null | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-06 | 1 | 38969928 | [] | [] | 0 | 10.1007/s00262-024-03727-0 | [
"Jancewicz",
"Śmiech",
"Winiarska",
"Zagozdzon",
"Wisniewski"
] | [
"4Cell Therapies S.A., 59C Bojkowska Street, 44-100, Gliwice, Poland.",
"4Cell Therapies S.A., 59C Bojkowska Street, 44-100, Gliwice, Poland.",
"4Cell Therapies S.A., 59C Bojkowska Street, 44-100, Gliwice, Poland.\nDepartment of Immunology, Medical University of Warsaw, 5 Nielubowicza St., Building F, 02-097, Warsaw, Poland.\nLaboratory of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawinskiego Str., 02-106, Warsaw, Poland.",
"4Cell Therapies S.A., 59C Bojkowska Street, 44-100, Gliwice, Poland. [email protected].\nLaboratory of Cellular and Genetic Therapies, Medical University of Warsaw, Banacha 1B, 02-097, Warsaw, Poland. [email protected].\nDepartment of Regenerative Medicine, The Maria Sklodowska-Curie National Research Institute of Oncology, 5 Roentgena Street, 02-781, Warsaw, Poland. [email protected].",
"4Cell Therapies S.A., 59C Bojkowska Street, 44-100, Gliwice, Poland. [email protected]."
] | [
"38969928"
] | [] | 32.940002 | 7.512385 |
38969565 | 756 | FDG-PET/CT Imaging in Chimeric Antigen Receptor-Engineered T-Cell Treatment in Patients with B-Cell Lymphoma: Current Evidence. | The Food and Drug Administration and the European Medicines Agency have recently approved chimeric antigen receptor-engineered (CAR) T cells to treat several refractory/relapsed B-cell lymphomas. This comprehensive review aims to demonstrate the pivotal role that [ | [
0.010015313513576984,
0.022338302806019783,
0.021334463730454445,
0.04979964718222618,
-0.01171722449362278,
-0.011399919167160988,
-0.029284408316016197,
0.040799710899591446,
0.007009565830230713,
-0.0016413345001637936,
-0.003086516633629799,
-0.04292277246713638,
-0.05699959397315979,
0.030207477509975433,
0.018507560715079308,
-0.024115214124321938,
0.02531520463526249,
-0.013130676001310349,
0.04234585538506508,
0.04181508719921112,
0.011786455288529396,
-0.004214392974972725,
-0.011347996070981026,
0.01891140453517437,
-0.07407639920711517,
-0.03235361725091934,
-0.0011898954398930073,
0.018830636516213417,
-0.025707509368658066,
-0.06124572083353996,
0.018980635330080986,
-0.018403716385364532,
-0.006069187540560961,
0.01811525598168373,
-0.005434576887637377,
0.021046005189418793,
0.007338409312069416,
-0.011019152589142323,
-0.021588308736681938,
0.0017033532494679093,
0.011999915353953838,
0.026445966213941574,
0.05524576082825661,
0.08529170602560043,
-0.05884573608636856,
0.013315290212631226,
-0.031199779361486435,
-0.02489982359111309,
0.01535758376121521,
-0.015276814810931683,
-0.016892187297344208,
0.01299221534281969,
-0.024392135441303253,
0.037938192486763,
-0.06863028556108475,
0.05039964243769646,
-0.014584511518478394,
0.030207477509975433,
-0.00274180737324059,
0.03565359488129616,
-0.0063634165562689304,
-0.004326892551034689,
0.01887678913772106,
-0.005870150867849588,
-0.10052236169576645,
0.005454768892377615,
-0.04668428376317024,
-0.030369015410542488,
0.008717245422303677,
0.032884381711483,
0.0189690962433815,
0.003897087648510933,
0.0028932488057762384,
-0.0044826604425907135,
0.05386115610599518,
-0.003167285118252039,
0.018230639398097992,
0.03724588826298714,
0.010251850821077824,
0.008284556679427624,
-0.008844167925417423,
0.009819161146879196,
-0.00810571201145649,
-0.04675351455807686,
-0.002376906108111143,
-0.023884445428848267,
0.018922943621873856,
0.0046326592564582825,
-0.015126815997064114,
0.0008617727435193956,
0.012588372454047203,
0.013488366268575191,
-0.0806763544678688,
0.06479953974485397,
-0.018184486776590347,
0.05552268400788307,
-0.05312269926071167,
-0.0189690962433815,
0.022222919389605522,
0.048645809292793274,
0.05118425190448761,
0.011728762648999691,
-0.04227662459015846,
-0.020688313990831375,
0.04289969429373741,
-0.022153688594698906,
-0.02466905675828457,
-0.004560544621199369,
0.04114586114883423,
-0.023907523602247238,
0.04712274298071861,
0.001507200882770121,
-0.023122912272810936,
0.038861263543367386,
-0.04405353218317032,
-0.03115362487733364,
-0.003467283211648464,
0.0035422826185822487,
0.005048041231930256,
0.013765286654233932,
-0.017976796254515648,
0.04211508482694626,
0.04386891797184944,
-0.06729183346033096,
0.014907586388289928,
0.02322675846517086,
0.07555331289768219,
-0.02965363673865795,
-0.007528792601078749,
-0.04236892983317375,
0.03844588249921799,
-0.00425766222178936,
0.037430502474308014,
-0.00743648549541831,
-0.0504457950592041,
-0.001755275996401906,
-0.011088382452726364,
-0.056630369275808334,
-0.07647638022899628,
0.00020336394663900137,
0.01450374349951744,
-0.0180575642734766,
-0.020976774394512177,
-0.009576855227351189,
-0.014896048232913017,
-0.030899781733751297,
-0.01649988256394863,
0.017780642956495285,
0.013176829554140568,
0.00692302780225873,
-0.06078418344259262,
0.03770742565393448,
0.042992003262043,
-0.02090754359960556,
-0.002022101078182459,
-0.07610715180635452,
-0.005737459287047386,
0.04924580454826355,
0.006824951618909836,
-0.036461278796195984,
-0.022592147812247276,
0.007799944840371609,
-0.03955356404185295,
-0.02854595147073269,
0.008123019710183144,
-0.00603457260876894,
-0.03297669067978859,
0.03629974275827408,
-0.05819958820939064,
0.025130590423941612,
-0.05796882137656212,
-0.038861263543367386,
-0.039599720388650894,
-0.004964387975633144,
-0.05847650766372681,
0.025892123579978943,
0.04719197377562523,
0.017976796254515648,
-0.01299221534281969,
-0.04160739853978157,
0.007632638327777386,
0.03556128591299057,
0.00872301496565342,
-0.0022456571459770203,
0.0026682503521442413,
0.014319129288196564,
-0.026053661480545998,
-0.004145163111388683,
-0.04836888611316681,
0.007223025895655155,
0.03062286041676998,
0.03426898643374443,
0.04636120796203613,
-0.020446008071303368,
0.002512482227757573,
-0.01659218966960907,
0.018346024677157402,
-0.007171102799475193,
0.006686490960419178,
-0.013199906796216965,
0.00069013936445117,
-0.024738285690546036,
-0.02522289752960205,
0.0009490317315794528,
-0.021219080314040184,
-0.024738285690546036,
-0.009219164960086346,
0.027345959097146988,
-0.004820158239454031,
-0.018242178484797478,
0.033022843301296234,
-0.03438436985015869,
-0.004096124786883593,
0.02639981359243393,
-0.07172256708145142,
-0.017919104546308517,
0.0011163381859660149,
0.02789980173110962,
0.04211508482694626,
0.02619212120771408,
0.006513415370136499,
-0.006063418462872505,
0.0207921601831913,
0.011797993443906307,
-0.06955335289239883,
0.0021432540379464626,
0.007984559051692486,
-0.03740742802619934,
-0.025499818846583366,
-0.007661484181880951,
0.014734511263668537,
0.016603728756308556,
-0.003164400579407811,
-0.02953825145959854,
-0.043061234056949615,
-0.005319193005561829,
0.03749973326921463,
-0.0019341208972036839,
0.046384286135435104,
-0.015899887308478355,
-0.011117229238152504,
0.017896026372909546,
0.04566890746355057,
-0.027415189892053604,
-0.0231113750487566,
0.008774938061833382,
-0.003481706138700247,
-0.05141501873731613,
0.02983824908733368,
0.004018240608274937,
-0.009409548714756966,
0.042830467224121094,
0.010742231272161007,
-0.01454989705234766,
0.03265361487865448,
0.009155704639852047,
0.036945890635252,
-0.012553757056593895,
-0.002613442949950695,
-0.0019081595819443464,
-0.00891339872032404,
0.02651519700884819,
-0.035953592509031296,
-0.03459206223487854,
-0.05944573134183884,
0.013626825995743275,
0.003853818867355585,
0.011561456136405468,
0.033576685935258865,
-0.0011956646339967847,
0.034015145152807236,
0.024115214124321938,
0.09378395229578018,
-0.01641911454498768,
-0.04107663035392761,
-0.0059768809005618095,
0.025845970958471298,
0.04188431799411774,
0.003441321663558483,
0.012149914167821407,
0.015034508891403675,
-0.022280611097812653,
0.0006118947057984769,
-0.031407468020915985,
-0.013753748498857021,
-0.016926802694797516,
0.023445988073945045,
-0.0031528621912002563,
-0.00004369710586615838,
-0.0045865061692893505,
0.005581691395491362,
-0.008198019117116928,
0.011082613840699196,
-0.0365305095911026,
-0.03094593435525894,
0.015069124288856983,
-0.0053797694854438305,
-0.017053725197911263,
-0.011388381011784077,
0.010436464101076126,
-0.013476827181875706,
0.023469064384698868,
-0.014538358896970749,
-0.04061509668827057,
0.01149799581617117,
0.04643043875694275,
-0.013776825740933418,
-0.06290724873542786,
0.03380745276808739,
0.03823819011449814,
0.03729204460978508,
-0.024715209379792213,
0.03602282330393791,
-0.0020725815556943417,
0.008157634176313877,
-0.0030432476196438074,
0.03267669305205345,
-0.052753470838069916,
0.015726812183856964,
-0.060830336064100266,
0.001983158988878131,
-0.006738413590937853,
-0.052107322961091995,
-0.006340339779853821,
-0.01853063702583313,
-0.032192081212997437,
-0.00689995102584362,
-0.028822872787714005,
0.022569071501493454,
-0.024876747280359268,
0.020653700456023216,
-0.0009620123892091215,
0.05999957397580147,
0.003285553539171815,
0.0037730501499027014,
0.004090355709195137,
-0.001586527214385569,
-0.03613820672035217,
0.03503052145242691,
0.021980613470077515,
0.03999202325940132,
-0.004606698174029589,
-0.046384286135435104,
0.05215347558259964,
0.023330604657530785,
0.008769168518483639,
-0.007574946153908968,
0.015369121916592121,
-0.011019152589142323,
0.01358067337423563,
-0.03433821722865105,
-0.002032197080552578,
0.022707531228661537,
-0.024115214124321938,
-0.010448003187775612,
0.0062941862270236015,
-0.042992003262043,
-0.0011668186634778976,
0.009703777730464935,
-0.013165291398763657,
0.01471143402159214,
0.017019109800457954,
-0.008901859633624554,
0.03348437696695328,
0.009421086870133877,
0.049845799803733826,
-0.0057057286612689495,
0.023249834775924683,
-0.028799796476960182,
-0.053953465074300766,
-0.009490317665040493,
-0.015057585202157497,
0.007453793194144964,
-0.006871105171740055,
-0.024184443056583405,
0.027876725420355797,
0.01459605060517788,
0.00019885676738340408,
-0.005255731754004955,
-0.015103738754987717,
0.029122870415449142,
-0.0050624641589820385,
-0.0007752348901703954,
-0.05483037978410721,
0.00362593587487936,
0.023469064384698868,
-0.008463401347398758,
-0.010061467066407204,
-0.06447646766901016,
0.013234521262347698,
-0.03359976038336754,
-0.010621078312397003,
0.02780749462544918,
0.011596071533858776,
0.0027778649237006903,
0.08178403228521347,
0.00983646884560585,
0.07541485130786896,
0.053815003484487534,
0.010534540750086308,
-0.0050422721542418,
-0.03062286041676998,
0.006634568329900503,
-0.0016052770661190152,
0.021749846637248993,
0.0027461342979222536,
0.01744602993130684,
0.007661484181880951,
0.0051345787942409515,
-0.022072920575737953,
-0.010569156147539616,
0.015438351780176163,
0.02552289515733719,
0.020134473219513893,
0.004502852912992239,
-0.008509554900228977,
-0.029030563309788704,
0.03683050721883774,
-0.013407597318291664,
0.014849894680082798,
0.027022885158658028,
-0.034661293029785156,
0.03156900778412819,
0.0002619572915136814,
-0.009080705232918262,
-0.020272932946681976,
0.024622902274131775,
-0.0034268987365067005,
-0.01794218085706234,
-0.027438266202807426,
-0.02900748699903488,
0.03558436408638954,
0.01055761706084013,
-0.0242305975407362,
0.01729603111743927,
-0.005440345965325832,
-0.013280674815177917,
-0.012969139032065868,
-0.014676818624138832,
-0.010869153775274754,
-0.044976603239774704,
-0.006196110043674707,
0.026445966213941574,
-0.036599740386009216,
-0.005627844482660294,
0.002260080073028803,
0.014411436393857002,
0.02533828094601631,
-0.03489205986261368,
0.00593072734773159,
0.007563407998532057,
-0.032930534332990646,
0.005861497018486261,
-0.0035163213033229113,
-0.08039943128824234,
-0.00445669936016202,
0.02469213306903839,
-0.030115170404314995,
-0.014411436393857002,
0.005114386789500713,
0.041330475360155106,
-0.013984516263008118,
0.01196529995650053,
-0.03588436171412468,
0.01115761324763298,
0.04550737142562866,
0.018346024677157402,
0.0076672532595694065,
0.02014601044356823,
-0.0564919076859951,
0.026030585169792175,
-0.009576855227351189,
-0.040799710899591446,
0.017965257167816162,
0.0008127345936372876,
0.014134515076875687,
0.001163934008218348,
0.02284599095582962,
0.03306899592280388,
-0.005114386789500713,
-0.021357540041208267,
-0.007257640827447176,
-0.0453919842839241,
-0.0018158524762839079,
0.025615202262997627,
0.01723833940923214,
-0.02695365436375141,
0.007084565237164497,
-0.0375228114426136,
0.04707659035921097,
-0.015807580202817917,
0.00611534109339118,
-0.005218232050538063,
-0.009571085684001446,
0.0030922857113182545,
-0.020988313481211662,
-0.017872950062155724,
-0.012046067975461483,
-0.02052677795290947,
0.02813057042658329,
-0.006559568922966719,
0.01881909742951393,
-0.012046067975461483,
0.025153668597340584,
0.013857593759894371,
0.038422804325819016,
-0.009934544563293457,
0.059861112385988235,
0.020503701642155647,
0.009698008187115192,
-0.01862294413149357,
-0.018022948876023293,
0.024876747280359268,
-0.01596911810338497,
-0.038630496710538864,
-0.01299221534281969,
-0.04550737142562866,
-0.018403716385364532,
-0.014215284027159214,
0.003957664128392935,
-0.00181296793743968,
-0.0016312383813783526,
-0.00611534109339118,
0.019546015188097954,
0.01394990086555481,
-0.004759581759572029,
-0.010886461474001408,
-0.027553651481866837,
-0.05399961769580841,
-0.02554597333073616,
0.05067656189203262,
-0.01217299047857523,
0.0037903578486293554,
0.01841525360941887,
-0.00891339872032404,
0.004572082776576281,
-0.019488323479890823,
0.04181508719921112,
-0.01218452863395214,
-0.021311387419700623,
-0.00010069039126392454,
0.006582645699381828,
0.02041139453649521,
-0.01096722949296236,
-0.010713385418057442,
0.004624005872756243,
-0.012496065348386765,
-0.026676733046770096,
0.03336899355053902,
0.006674952805042267,
0.04749197140336037,
-0.020503701642155647,
0.006374954711645842,
-0.003501898143440485,
0.003530744230374694,
-0.02810749225318432,
-0.02446136437356472,
-0.054045770317316055,
0.008498016744852066,
-0.056307293474674225,
-0.016603728756308556,
-0.008169173263013363,
0.033899758011102676,
-0.004802850540727377,
-0.0577380508184433,
0.01670757308602333,
-0.00791532825678587,
0.019015248864889145,
-0.02953825145959854,
0.023745985701680183,
0.004635544028133154,
0.018957557156682014,
0.01481527928262949,
0.0014733069110661745,
0.013626825995743275,
0.013349905610084534,
0.006224955897778273,
0.016199884936213493,
-0.014999893493950367,
0.029699789360165596,
-0.028615182265639305,
-0.022453686222434044,
-0.014665280468761921,
0.029699789360165596,
-0.018576791509985924,
0.010655693709850311,
-0.039299722760915756,
-0.03048439882695675,
-0.027230575680732727,
0.00694610457867384,
0.02909979410469532,
0.03113054856657982,
0.023976752534508705,
0.02619212120771408,
-0.019546015188097954,
0.016661420464515686,
0.0017999872798100114,
0.010978768579661846,
-0.027876725420355797,
0.009576855227351189,
0.0015115276910364628,
0.009046089835464954,
-0.004935542121529579,
-0.04566890746355057,
-0.04966118559241295,
0.02813057042658329,
0.005327846854925156,
-0.03805357590317726,
-0.008728784509003162,
0.015807580202817917,
0.056307293474674225,
0.034661293029785156,
-0.03168439120054245,
0.032169003039598465,
0.04474583640694618,
0.04513814300298691,
-0.0035826668608933687,
0.005610537249594927,
0.0048951576463878155,
-0.02489982359111309,
-0.015980655327439308,
0.007840328849852085,
-0.010724923573434353,
-0.006288417149335146,
-0.015784503892064095,
-0.05109194666147232,
-0.008169173263013363,
0.026653656736016273,
0.0221998430788517,
-0.0013146541314199567,
-0.009248011745512486,
-0.020953698083758354,
0.011838377453386784,
0.048876576125621796,
-0.025476742535829544,
-0.03899972513318062,
0.029792096465826035,
-0.024599825963377953,
-0.002959594363346696,
0.03207669407129288,
0.011884531006217003,
-0.02278829924762249,
0.010517233051359653,
-0.029053639620542526,
0.017376799136400223,
-0.02176138386130333,
-0.023515217006206512,
-0.0014956624945625663,
0.002613442949950695,
-0.008907629176974297,
-0.0192575566470623,
-0.029445944353938103,
0.01384605560451746,
-0.008290326222777367,
0.0017466222634539008,
-0.015865271911025047,
-0.004935542121529579,
0.02146138623356819,
0.05321500822901726,
0.06133802607655525,
-0.002691327128559351,
-0.019661398604512215,
0.02466905675828457,
-0.02554597333073616,
-0.014469128102064133,
-0.007246102672070265,
0.03708435222506523,
0.005036502610892057,
0.006853797473013401,
0.024876747280359268,
0.06263032555580139,
0.014930663630366325,
-0.01400759257376194,
-0.020538315176963806,
0.004364392254501581,
-0.02965363673865795,
-0.013730672188103199,
-0.02372290939092636,
-0.033022843301296234,
0.015230661258101463,
-0.001724987756460905,
0.015922963619232178,
-0.02748442068696022,
-0.04313046485185623,
0.02466905675828457,
-0.015599889680743217,
0.010332618840038776,
-0.003499013604596257,
0.020249856635928154,
0.014965278096497059,
-0.02208445966243744,
-0.0028153646271675825,
0.004122086334973574,
-0.00015919358702376485,
0.02856902778148651,
-0.00044891508878208697,
0.020872928202152252,
-0.033230531960725784,
-0.01929217018187046,
-0.011394149623811245,
0.02123061940073967,
0.03364591673016548,
0.02566135674715042,
-0.02953825145959854,
0.010038390755653381,
-0.01621142402291298,
-0.007119180168956518,
-0.014942201785743237,
0.008226864971220493,
0.016292192041873932,
0.013557596132159233,
-0.026999808847904205,
-0.01838063821196556,
-0.02096523530781269,
0.0055384221486747265,
0.011347996070981026,
-0.00773071451112628,
0.053491927683353424,
-0.0024201751220971346,
0.031222855672240257,
-0.004820158239454031,
0.03953048959374428,
-0.010828769765794277,
0.007430716417729855,
0.03359976038336754,
0.021161388605833054,
-0.007188410498201847,
0.0484611950814724,
-0.0178498737514019,
-0.014734511263668537,
-0.029815172776579857,
-0.02965363673865795,
-0.016580652445554733,
0.012761447578668594,
0.004214392974972725,
0.02552289515733719,
0.0005242751212790608,
-0.04232277721166611,
-0.011290304362773895,
-0.026469042524695396,
0.01487297099083662,
-0.030230555683374405,
-0.04096124693751335,
0.030576705932617188,
-0.01676526665687561,
0.014180668629705906,
0.0217036921530962,
0.004358622711151838,
-0.026122892275452614,
-0.045945826917886734,
-0.01668449677526951,
0.0075172544457018375,
0.014584511518478394,
0.005798035766929388,
-0.025153668597340584,
-0.052753470838069916,
0.013776825740933418,
-0.000364901265129447,
-0.05321500822901726,
-0.019015248864889145,
-0.023676754906773567,
0.017422953620553017,
-0.01556527428328991,
-0.010840307921171188,
0.0030230553820729256,
-0.020019087940454483,
0.000867541937623173,
0.03203054144978523,
-0.004127855412662029,
-0.026053661480545998,
-0.03166131302714348,
0.002759115071967244,
0.011930684559047222,
-0.02900748699903488,
-0.0375228114426136,
0.03149977698922157,
-0.0037413195241242647,
0.01761910505592823,
-0.029699789360165596,
0.016107577830553055,
-0.00028070714324712753,
-0.02231522649526596,
-0.027022885158658028,
0.01277298666536808,
-0.010003775358200073,
-0.002640846651047468,
0.018426792696118355,
-0.0016124885296449065,
-0.03126901015639305,
0.008861475624144077,
-0.016615265980362892,
0.03588436171412468,
-0.001559123513288796,
0.0018331600585952401,
-0.016949879005551338,
0.03535359725356102,
0.028430568054318428,
-0.05644575506448746,
-0.013753748498857021,
-0.008630707859992981,
-0.021588308736681938,
-0.01900371164083481,
-0.004973041824996471,
-0.03477667644619942,
0.016638344153761864,
0.018484484404325485,
-0.015322968363761902,
0.04645351693034172,
-0.012242221273481846,
0.011353765614330769,
0.002327868016436696,
-0.01486143283545971,
-0.023353680968284607,
-0.018992172554135323,
-0.0337151437997818,
-0.014076823368668556,
0.03650743514299393,
0.015172969549894333,
0.008792245760560036,
0.009605701081454754,
0.028430568054318428,
0.0010521559743210673,
0.024599825963377953,
-0.008065327070653439,
0.009553777985274792,
-0.014076823368668556,
0.009865314699709415,
0.004416314885020256,
0.02501520700752735,
-0.01858833059668541,
0.018692174926400185,
0.012911447323858738,
-0.04223046824336052,
0.017042186111211777,
-0.013003753498196602,
-0.02566135674715042,
-0.017965257167816162,
0.003164400579407811,
0.01803448796272278,
0.002503828378394246,
0.016776803880929947,
-0.016615265980362892,
-0.039507411420345306,
-0.026422889903187752,
-0.005832651164382696,
0.014134515076875687,
-0.0042432392947375774,
0.03136131539940834,
-0.024415211752057076,
-0.024299828335642815,
0.008376863785088062,
-0.024438288062810898,
-0.02619212120771408,
-0.007321102079004049,
0.06064572557806969,
0.032261308282613754,
-0.0058557274751365185,
-0.017434490844607353,
0.0625380203127861,
0.005630729254335165,
-0.014365282841026783,
0.0015822002897039056,
-0.012103760614991188,
-0.05099963769316673,
0.05312269926071167,
-0.023838292807340622,
-0.0021273887250572443,
-0.04373046010732651,
0.027945956215262413,
-0.01929217018187046,
0.029884403571486473,
-0.01491912454366684,
0.015230661258101463,
-0.005924957804381847,
0.010205697268247604,
0.016026809811592102,
-0.00364901265129447,
-0.027715187519788742,
-0.02736903727054596,
-0.028822872787714005,
-0.00692302780225873,
-0.03103824146091938,
-0.0022802723105996847,
-0.009357625618577003,
0.017699874937534332,
0.02651519700884819,
-0.017249878495931625,
-0.015299891121685505,
0.01600373350083828,
0.0010514348978176713,
0.015242199413478374,
0.014780664816498756,
-0.0037211275193840265,
-0.021565232425928116,
0.0040701632387936115,
-0.01540373731404543,
-0.037453580647706985,
0.05183040350675583,
-0.022211380302906036,
0.014526819810271263,
-0.045968905091285706,
-0.034961290657520294,
-0.04202277958393097,
0.02204984426498413,
-0.014226822182536125,
-0.017169108614325523,
-0.018507560715079308,
0.04126124456524849,
-0.006380723789334297,
0.04536890983581543,
-0.029330560937523842,
-0.006121110636740923,
0.01853063702583313,
0.008232633583247662,
-0.010269157588481903,
0.006005726754665375,
0.007073026616126299,
0.04739966243505478,
-0.015138354152441025,
-0.008803783915936947,
-0.0016932572470977902,
0.01982293650507927,
0.010038390755653381,
-0.00400958675891161,
0.00372978113591671,
0.003343245480209589,
0.0038018960040062666,
0.025730587542057037,
0.011244150809943676,
0.013649903237819672,
-0.013072984293103218,
-0.004378815181553364,
0.0337151437997818,
-0.0005141790607012808,
0.014088361524045467,
0.01023454312235117,
0.023745985701680183,
-0.01400759257376194,
-0.017872950062155724,
0.025569049641489983,
-0.002050946932286024,
0.03256130591034889,
-0.008567246608436108,
-0.06932258605957031,
0.048876576125621796,
0.01588834822177887,
-0.006917258724570274,
-0.04073048010468483,
0.02921517752110958,
0.06249186396598816,
0.045207370072603226,
-0.0030201708432286978,
0.028799796476960182,
0.0072634099051356316,
-0.030738243833184242,
-0.0226152241230011,
0.026030585169792175,
-0.051461175084114075,
0.04709966480731964,
-0.014515281654894352,
-0.02269599214196205,
-0.005575921852141619,
-0.014584511518478394,
0.01024608127772808,
-0.0001927270059240982,
0.03221515566110611,
0.01723833940923214,
0.0186806358397007,
-0.07010719180107117,
0.0415843203663826,
0.002780749462544918,
-0.015980655327439308,
0.03143054619431496,
0.04465353116393089,
0.030253631994128227,
0.01396143902093172,
0.037453580647706985,
-0.03138439357280731,
-0.0033490147907286882,
-0.007696099113672972,
0.031638238579034805,
0.011694148182868958,
-0.0042374697513878345,
-0.002187965204939246,
-0.028153646737337112,
0.009334549307823181,
0.019153710454702377,
-0.01177491620182991,
-0.03909203037619591,
0.031407468020915985,
0.040661249309778214,
0.01761910505592823,
-0.020780621096491814,
-0.03523821011185646,
0.03447667881846428,
-0.020872928202152252,
-0.025569049641489983,
-0.03687665984034538,
0.033784374594688416,
0.054045770317316055,
-0.013072984293103218,
-0.019846012815833092,
0.0010031178826466203,
0.03782280907034874,
-0.0452304482460022,
0.003331707092002034,
0.03343822434544563,
0.038307420909404755,
0.018449869006872177,
-0.016453729942440987,
0.020099857822060585,
0.03482282906770706,
-0.007390332408249378,
-0.004851888865232468,
0.004733620211482048,
-0.03295361250638962,
-0.00007378253212664276,
-0.023088298738002777,
-0.05496884137392044,
-0.0021259465720504522,
0.010182620026171207,
-0.0010456657037138939,
0.010367234237492085,
0.022188303992152214,
0.016869110986590385,
0.006161494646221399,
0.024184443056583405,
-0.026538273319602013,
0.022003689780831337,
0.014572973363101482,
0.009871084243059158,
0.007280717603862286,
-0.033876683562994,
0.005844189319759607,
-0.0101480046287179,
-0.003995163831859827,
-0.014284513890743256,
0.03773050010204315,
0.020272932946681976,
0.01104222983121872,
-0.008798014372587204,
-0.012484527193009853,
0.009069166146218777,
0.05035348981618881,
-0.0005989140481688082,
0.012138375081121922,
-0.03403821960091591,
-0.04449199140071869,
0.007407639641314745,
0.019130634143948555,
0.023572910577058792,
0.024438288062810898,
0.0001891212596092373,
0.005650921259075403,
0.026699811220169067,
0.014272975735366344,
0.010407618246972561,
-0.01131915021687746,
0.012392220087349415,
-0.004811504390090704,
0.002772095613181591,
0.0341305285692215,
0.009640316478908062,
-0.017192184925079346,
-0.013569134287536144,
0.00953070167452097,
0.03869972378015518,
0.03138439357280731,
0.022742146626114845,
0.012103760614991188,
0.006582645699381828,
0.009311472065746784,
-0.025130590423941612,
0.003046132158488035,
-0.01293452363461256,
-0.013246060349047184,
-0.00861916970461607,
0.014330667443573475,
-0.0108518460765481,
-0.03339207172393799,
0.012057607062160969,
0.0373612716794014,
0.03946125879883766,
0.006663414184004068,
-0.0002587120980024338,
0.005526883993297815,
-0.026007506996393204,
-0.03016132488846779,
-0.0017523914575576782,
-0.03239976987242699,
-0.018403716385364532,
0.006392262410372496,
-0.008180711418390274,
-0.006334570236504078,
-0.009288395754992962,
0.009409548714756966,
-0.020192164927721024,
0.015611427836120129,
0.030553629621863365,
0.00368939689360559,
-0.016511421650648117,
0.011480688117444515,
-0.017272954806685448,
-0.0375228114426136,
-0.04495352879166603,
0.0577380508184433,
-0.0019759475253522396,
-0.03364591673016548,
0.003951895050704479,
0.016603728756308556,
-0.0229036845266819,
0.011792223900556564,
0.03170746564865112,
-0.047238126397132874,
0.034638214856386185,
0.00735571701079607,
0.011665302328765392,
-0.01647680625319481,
0.0076845609582960606,
-0.001566335093230009,
-0.018957557156682014,
-0.03274592012166977,
0.018022948876023293,
0.01617680862545967,
0.004462468437850475,
-0.01976524479687214,
-0.021634461358189583,
0.030530553311109543,
-0.004122086334973574,
-0.005252847447991371,
-0.003522090381011367,
-0.00008532090578228235,
0.00613841786980629,
0.006230724975466728,
0.014676818624138832,
0.020330624654889107,
-0.019580630585551262,
0.002257195534184575,
0.030738243833184242,
0.023630602285265923,
0.026122892275452614,
0.040038175880908966,
-0.022361379116773605,
0.0217036921530962,
-0.030369015410542488,
-0.030322862789034843,
0.0006227119592949748,
0.06143033504486084,
-0.03059978224337101,
-0.027184423059225082,
0.041999701410532,
0.005532653070986271,
-0.020365240052342415,
-0.0162345003336668,
0.026538273319602013,
0.010834538377821445,
-0.010223004035651684,
0.01460758876055479,
0.04195354878902435,
0.044445838779211044,
-0.02792287804186344,
-0.013926824554800987,
0.02434598095715046,
-0.022095996886491776,
-0.020953698083758354,
-0.014988355338573456,
0.03133824095129967,
0.011694148182868958,
0.017480645328760147,
-0.017111416906118393,
0.008786476217210293,
0.02123061940073967,
-0.005512461066246033,
0.05229193717241287,
0.0036317049525678158,
0.0008935032528825104,
0.03207669407129288,
-0.01105376798659563,
-0.002346617868170142,
-0.02138061821460724,
0.006830720696598291,
-0.0024850785266608,
-0.017157571390271187,
-0.015588350594043732,
-0.03359976038336754,
0.003925933502614498,
0.0013651344925165176,
0.013222983106970787,
-0.02022678032517433,
0.01891140453517437,
0.0014184995088726282,
-0.024807516485452652,
-0.020215241238474846,
-0.00907493568956852,
-0.01104222983121872,
-0.03586128354072571,
0.007292255759239197,
-0.0629533976316452,
-0.01568065769970417,
0.01838063821196556,
-0.00654803030192852,
0.009605701081454754,
0.026330582797527313,
-0.016719112172722816,
-0.001370182610116899,
0.017261415719985962,
0.03579205274581909,
-0.020284472033381462,
-0.012265297584235668,
-0.04001510143280029,
0.029792096465826035,
-0.01069030910730362,
-0.006005726754665375,
0.009928775951266289,
-0.023769062012434006,
-0.02343444898724556,
-0.0324690006673336,
0.01051146350800991,
-0.006207648199051619,
0.0008394171018153429,
-0.0020942159462720156,
0.03456898406147957,
0.0020870044827461243,
0.023515217006206512,
0.015276814810931683,
-0.04668428376317024,
0.020019087940454483,
-0.003360553178936243,
0.01638449914753437,
0.012576834298670292,
0.015253737568855286,
-0.04776889085769653,
0.016430653631687164,
-0.0015850849449634552,
0.001704795635305345,
-0.018726790323853493,
-0.0038595879450440407,
0.005748997908085585,
0.0186806358397007,
0.06069187819957733,
0.02598443068563938,
0.0175614133477211,
-0.022684454917907715,
-0.028730565682053566,
0.005492268595844507,
0.021622924134135246,
0.0061095720157027245,
0.014042207971215248,
0.006449954118579626,
-0.031892079859972,
-0.013569134287536144,
0.0050624641589820385,
0.013592211529612541,
-0.014942201785743237,
-0.0022341187577694654,
0.02434598095715046,
0.01293452363461256,
-0.03989971801638603,
-0.013926824554800987,
-0.003334591630846262,
0.023215219378471375,
0.005610537249594927,
-0.029284408316016197,
-0.01788448914885521,
-0.013880671001970768,
0.002327868016436696,
-0.021426770836114883,
0.0011660974705591798,
0.012565295211970806,
0.02854595147073269,
0.024207521229982376,
0.01217299047857523,
-0.029284408316016197,
0.03436129540205002,
0.03579205274581909,
0.012796062976121902,
-0.00953070167452097,
-0.01914217136800289,
0.010840307921171188,
-0.011809531599283218,
-0.029053639620542526,
0.023745985701680183,
0.015865271911025047,
0.005180732347071171,
-0.012703755870461464,
0.052661165595054626,
-0.012334528379142284,
-0.0004139393859077245,
-0.033784374594688416,
-0.006242263596504927,
0.00087835913291201,
-0.006957643199712038,
-0.010811462067067623,
-0.01606142520904541,
-0.01471143402159214,
-0.009738392196595669,
-0.00006841898721177131,
-0.004038433078676462,
0.007557638920843601,
0.02672288753092289,
-0.03556128591299057,
0.018842173740267754,
-0.009980698116123676,
-0.021311387419700623,
-0.07633791863918304,
0.00020588796178344637,
-0.01405374612659216,
-0.040892016142606735,
-0.01058646384626627,
-0.014226822182536125,
0.009421086870133877,
0.04451506957411766,
-0.02519982121884823,
-0.004329776857048273,
0.01879602111876011,
0.04073048010468483,
0.007280717603862286,
0.039807409048080444,
0.017157571390271187,
0.04146893694996834,
-0.009784545749425888,
-0.01368451863527298,
-0.031292084604501724,
-0.021565232425928116,
0.044884297996759415,
-0.023065220564603806,
0.016338346526026726,
0.020561393350362778,
-0.02660750411450863,
0.035722821950912476,
-0.014434512704610825,
-0.0043384307064116,
0.03415360301733017,
-0.01585373282432556,
0.010344156995415688,
-0.027092115953564644,
-0.003571128472685814,
0.0006475915433838964,
0.01647680625319481,
0.020953698083758354,
0.0075172544457018375,
0.0036057436373084784,
0.017399877309799194,
0.021865230053663254,
-0.002512482227757573,
-0.0058730351738631725,
-0.01843832992017269,
0.01177491620182991,
0.03955356404185295,
-0.01940755546092987,
-0.01034992653876543,
-0.011544149369001389,
-0.026053661480545998,
-0.01993831992149353,
0.011976838111877441,
-0.022984452545642853,
0.0003284832346253097,
0.018657559528946877,
-0.023469064384698868,
-0.0025961354840546846,
0.03200746700167656,
0.0037326659075915813,
0.006167264189571142,
-0.016869110986590385,
0.014826818369328976,
-0.006957643199712038,
0.00024086367920972407,
-0.0010031178826466203,
0.005391308106482029,
-0.02455367147922516,
0.003579782322049141,
-0.017526797950267792,
0.01697295717895031,
-0.016603728756308556,
-0.013557596132159233,
-0.007557638920843601,
-0.019476784393191338,
0.01596911810338497,
0.008769168518483639,
-0.025361359119415283,
-0.0036605510395020247,
-0.014688357710838318,
-0.014838356524705887,
-0.0434073843061924,
-0.010713385418057442,
-0.026792118325829506,
0.024761362001299858,
-0.0573226697742939,
0.02372290939092636,
-0.012634526006877422,
-0.007038411684334278,
0.0035249749198555946,
0.061476487666368484,
0.004742274060845375,
-0.001044944510795176,
-0.027092115953564644,
-0.035284366458654404,
-0.009813391603529453,
0.02469213306903839,
-0.014353744685649872,
-0.023538295179605484,
-0.002926421584561467,
0.002783634001389146,
0.0020264280028641224,
-0.01546142902225256,
-0.04924580454826355,
0.0028759411070495844,
-0.02326137386262417,
-0.01982293650507927,
-0.02187676727771759,
-0.005348038859665394,
-0.023792138323187828,
0.015299891121685505,
-0.03558436408638954,
0.016546037048101425,
0.011463380418717861,
0.020953698083758354,
0.027761342003941536,
0.0629533976316452,
-0.012196067720651627,
-0.007257640827447176,
-0.010205697268247604,
0.03523821011185646,
-0.017815258353948593,
-0.011734532192349434,
0.008342248387634754,
-0.02090754359960556,
-0.034430526196956635,
0.03456898406147957,
0.026330582797527313,
-0.01993831992149353,
-0.002799499314278364,
-0.015080662444233894,
-0.005607652477920055,
0.002750461222603917,
-0.03641512617468834,
0.009928775951266289,
-0.007240333128720522,
0.04070740193128586,
0.002037966391071677,
0.0022398880682885647,
-0.038745880126953125,
0.02284599095582962,
-0.0031038240995258093,
-0.030092094093561172,
-0.002355271717533469,
-0.007644176483154297,
-0.030553629621863365,
-0.007361486088484526,
0.025153668597340584,
0.018449869006872177,
0.03149977698922157,
0.0224075336009264,
-0.009490317665040493,
0.009092243388295174,
-0.020249856635928154,
0.004298046231269836,
0.03320745751261711,
-0.010090312920510769,
0.019453708082437515,
-0.019638322293758392,
0.019511399790644646,
-0.01841525360941887,
0.022234458476305008,
0.009963391348719597,
-0.030438246205449104,
0.007176872342824936,
-0.0189690962433815,
0.003885549260303378,
-0.026884425431489944,
-0.015749888494610786,
0.11953761428594589,
0.005177848041057587,
-0.003738434985280037,
0.020076781511306763,
-0.009144165553152561,
-0.021588308736681938,
-0.003164400579407811,
-0.019857551902532578,
0.017319107428193092,
-0.008774938061833382,
0.017215263098478317,
0.007055719383060932,
0.010251850821077824,
0.04142278432846069,
0.009161473251879215,
-0.009709546342492104,
-0.011734532192349434,
0.04469968378543854,
0.014526819810271263,
0.0032970919273793697,
0.013592211529612541,
0.012196067720651627,
-0.02575366385281086,
0.015184507705271244,
-0.006542261224240065,
0.004205739591270685,
0.01444605179131031,
0.005627844482660294,
0.020180625841021538,
-0.01668449677526951,
0.007205718196928501,
-0.011521072126924992,
-0.00226873392239213,
-0.011792223900556564,
-0.01540373731404543,
-0.010407618246972561,
0.004199970047920942,
-0.009496086277067661,
0.027092115953564644,
-0.001488451031036675,
0.019338324666023254,
0.0351228266954422,
-0.0028124800883233547,
0.032722845673561096,
0.008774938061833382,
0.0047451588325202465,
-0.016049886122345924,
0.0003124376817140728,
-0.008099942468106747,
-0.039715103805065155,
0.020215241238474846,
-0.0016341230366379023,
-0.011036460287868977,
-0.008509554900228977,
-0.03380745276808739,
-0.01206914521753788,
0.002622096799314022,
0.035930514335632324,
-0.009496086277067661,
-0.037661273032426834,
-0.010049928911030293,
0.014076823368668556,
0.02639981359243393,
0.012553757056593895,
0.00698071951046586
] | 2024-07-06 | 1 | 38969565 | [
"several refractory/relapsed B-cell lymphomas",
"the European Medicines Agency",
"chimeric antigen receptor-engineered (CAR) T cells",
"This comprehensive review",
"the pivotal role",
"The Food and Drug Administration",
"that"
] | [
"Adverse events",
"B-cell lymphoma",
"CAR-T",
"FDG",
"Non-Hodgkin lymphoma",
"PET/CT",
"Response"
] | 0 | 10.1016/j.cpet.2024.05.006 | [
"Abenavoli",
"Linguanti",
"Dercle",
"Berti",
"Lopci"
] | [
"Nuclear Medicine Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.",
"Nuclear Medicine Department, Ospedale San Donato, Via Pietro Nenni 20, Arezzo 52100, Italy; Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences \"Mario Serio\", University of Florence, Largo Brambilla 3, Florence 50134, Italy.",
"Department of Radiology, New York-Presbyterian Hospital, Columbia University Vagelos College of Physicians and Surgeons, 622 West 168th Street, New York, NY 10032, USA.",
"Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences \"Mario Serio\", University of Florence, Largo Brambilla 3, Florence 50134, Italy.",
"Nuclear Medicine Unit, IRCCS-Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milano CAP 20089, Italy. Electronic address: [email protected]."
] | [
"38969565"
] | [] | 7.856014 | 4.324537 |
38968149 | 757 | Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4-r cases. | B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood malignancy and is driven by multiple genetic alterations that cause maturation arrest and accumulation of abnormal progenitor B cells. Current treatment protocols with chemotherapy have led to favorable outcomes but are associated with significant toxicity and risk of side effects, highlighting the necessity for highly effective, less toxic, targeted drugs, even in subtypes with a favorable outcome. Here, we used multimodal single-cell sequencing to delineate the transcriptional, epigenetic, and immunophenotypic characteristics of 23 childhood BCP-ALLs belonging to the BCR::ABL1+, ETV6::RUNX1+, high hyperdiploid, and recently discovered DUX4-rearranged (DUX4-r) subtypes. Projection of the ALL cells along the normal hematopoietic differentiation axis revealed a diversity in the maturation pattern between the different BCP-ALL subtypes. Although the BCR::ABL1+, ETV6::RUNX1+, and high hyperdiploidy cells mainly showed similarities to normal pro-B cells, DUX4-r ALL cells also displayed transcriptional signatures resembling mature B cells. Focusing on the DUX4-r subtype, we found that the blast population displayed not only multilineage priming toward nonhematopoietic cells, myeloid, and T-cell lineages, but also an activation of phosphatidylinositol 3-kinase (PI3K)/AKT signaling that sensitized the cells to PI3K inhibition in vivo. Given the multilineage priming of DUX4-r blasts with aberrant expression of myeloid marker CD371 (CLL-1), we generated chimeric antigen receptor T cells, which effectively eliminated DUX4-r ALL cells in vivo. These results provide a detailed characterization of BCP-ALL at the single-cell level and reveal therapeutic vulnerabilities in the DUX4-r subtype, with implications for the understanding of ALL biology and new therapeutic strategies. | [
0.019887737929821014,
0.04405085742473602,
0.08555570244789124,
0.06297783553600311,
-0.02959141694009304,
-0.02997571974992752,
0.026156697422266006,
0.03477952256798744,
-0.005701511632651091,
0.00849071890115738,
-0.013354567810893059,
-0.018014254048466682,
0.01783411204814911,
-0.01375088095664978,
0.0484943725168705,
0.021497011184692383,
0.04726940393447876,
-0.04995953291654587,
-0.0058246091939508915,
0.03134480491280556,
-0.0004552352475002408,
-0.016164790838956833,
0.035187844187021255,
-0.013498681597411633,
0.02872673235833645,
-0.004440513905137777,
0.0009975393768399954,
-0.027621857821941376,
0.0001313539396505803,
-0.024691538885235786,
-0.003461739281192422,
-0.01537216454744339,
-0.019659556448459625,
0.003269587177783251,
-0.017738036811351776,
0.008220504969358444,
0.014051118865609169,
0.029062997549772263,
-0.018650759011507034,
-0.030552176758646965,
0.04469937086105347,
-0.047629691660404205,
0.02841448411345482,
0.0016317912377417088,
-0.031080594286322594,
0.006989530753344297,
-0.0035638201516121626,
-0.01815836876630783,
0.03670104220509529,
0.03492363542318344,
0.008526747114956379,
0.040664177387952805,
0.021725190803408623,
0.06110435351729393,
-0.0897350087761879,
0.03855050727725029,
-0.0098477927967906,
-0.0033476490061730146,
-0.00372594827786088,
-0.018518654629588127,
0.018830901011824608,
0.007511944510042667,
0.01371485274285078,
0.014591546729207039,
-0.019047072157263756,
-0.012261702679097652,
-0.05284181609749794,
-0.04967130720615387,
0.03492363542318344,
-0.0009472495876252651,
-0.0085327522829175,
-0.03160901367664337,
-0.0037439626175910234,
-0.022061457857489586,
0.05995143949985504,
-0.0007003041682764888,
0.03189723938703537,
0.04640471935272217,
-0.034323159605264664,
0.0030293972231447697,
0.015624363906681538,
-0.0036899198312312365,
0.04340234398841858,
-0.03852648660540581,
-0.011024723760783672,
-0.005851630587130785,
0.04717332869768143,
0.02009189873933792,
-0.036028508096933365,
-0.025219956412911415,
0.00041845612577162683,
-0.0499114952981472,
-0.048013992607593536,
0.04611649364233017,
0.010093987919390202,
0.017497846856713295,
-0.0030954494141042233,
-0.04472339153289795,
0.030143853276968002,
0.01707751303911209,
0.028486542403697968,
0.008844999596476555,
0.02263791300356388,
-0.022745998576283455,
0.03381876274943352,
-0.03758974373340607,
-0.02673315443098545,
0.01050231046974659,
0.02078844979405403,
-0.015612354502081871,
0.039295095950365067,
0.04008772224187851,
-0.012585959397256374,
0.03574028238654137,
-0.019563481211662292,
-0.092136912047863,
-0.04150484502315521,
-0.018206406384706497,
0.0013428125530481339,
0.04023183509707451,
-0.005938699468970299,
0.04224943369626999,
0.009853797033429146,
-0.0467890240252018,
0.00187348248437047,
-0.03955930471420288,
0.07075999677181244,
-0.02040414698421955,
-0.01420724205672741,
-0.07441088557243347,
0.004809806123375893,
-0.007199697196483612,
-0.020187975838780403,
-0.01136098988354206,
-0.04796595498919487,
-0.005401274189352989,
-0.02148500084877014,
0.007968305610120296,
-0.028390465304255486,
-0.01683732308447361,
0.0248836912214756,
0.03977547585964203,
0.009487507864832878,
-0.001618280541151762,
-0.023622693493962288,
0.00849071890115738,
-0.0029558390378952026,
0.015011878684163094,
0.006268960889428854,
0.044146932661533356,
-0.024235177785158157,
0.012297730892896652,
-0.0029603424482047558,
0.0186987966299057,
0.014819727279245853,
-0.06446701288223267,
0.024691538885235786,
0.05908675491809845,
-0.023778816685080528,
-0.04558807611465454,
0.007638044189661741,
0.03305015340447426,
-0.039823513478040695,
-0.050632067024707794,
-0.0017774064326658845,
0.0017729029059410095,
-0.01814636029303074,
0.02764587663114071,
-0.05476333573460579,
-0.015432211570441723,
0.008358614519238472,
0.007872229442000389,
-0.07767746597528458,
-0.02209748513996601,
-0.040135759860277176,
-0.045684151351451874,
-0.022926142439246178,
-0.021280840039253235,
-0.03513980656862259,
-0.05894264206290245,
0.05822207033634186,
0.01737775094807148,
0.06187295913696289,
-0.018338510766625404,
-0.017882149666547775,
0.02735764905810356,
-0.016344934701919556,
0.010418243706226349,
-0.012009503319859505,
0.008965094573795795,
0.03160901367664337,
-0.018806882202625275,
-0.009199279360473156,
0.01540819276124239,
0.0029408270493149757,
-0.002897292608395219,
0.05827011168003082,
0.07628436386585236,
-0.019275253638625145,
0.025123881176114082,
0.027333630248904228,
-0.0125139020383358,
-0.00492089381441474,
-0.02326240763068199,
0.0016453019343316555,
0.011613189242780209,
0.017521865665912628,
0.025292014703154564,
-0.012465864419937134,
-0.02983160689473152,
0.02966347336769104,
0.005119050852954388,
-0.036340758204460144,
0.052889853715896606,
0.012838158756494522,
-0.054427068680524826,
0.0006507649668492377,
0.014927812851965427,
0.02131686918437481,
-0.026084640994668007,
0.04957522824406624,
-0.016332924365997314,
0.003674908075481653,
0.03638879582285881,
-0.022986188530921936,
-0.009445474483072758,
0.022433752194046974,
-0.02094457298517227,
-0.016176801174879074,
-0.00013642045087181032,
0.030384043231606483,
0.03547607362270355,
0.006905464455485344,
-0.022986188530921936,
-0.008220504969358444,
-0.0030188888777047396,
0.018350521102547646,
0.009253322146832943,
0.046164531260728836,
-0.04818212613463402,
-0.03489961475133896,
0.02147299237549305,
-0.021124716848134995,
-0.005875649396330118,
0.021040650084614754,
0.0045155733823776245,
-0.0017683993792161345,
-0.053418271243572235,
0.014627574943006039,
-0.011943451128900051,
-0.001966556068509817,
0.04765370860695839,
-0.01636895351111889,
-0.0269493255764246,
-0.008412657305598259,
0.01884291134774685,
0.031849201768636703,
-0.0026405896060168743,
-0.015011878684163094,
-0.008941074833273888,
-0.015095945447683334,
0.02030806988477707,
-0.04256168007850647,
-0.026156697422266006,
-0.034491293132305145,
0.03067227080464363,
0.03218546882271767,
-0.003365663345903158,
0.009493512101471424,
-0.0014974349178373814,
-0.020896535366773605,
-0.0013270501513034105,
0.008202490396797657,
-0.06408271193504333,
-0.054811373353004456,
-0.012111583724617958,
-0.006214918103069067,
0.0024634492583572865,
-0.02627679333090782,
0.02673315443098545,
-0.01567240245640278,
-0.0017533875070512295,
0.03715740144252777,
0.02827037125825882,
-0.017017466947436333,
0.010148030705749989,
-0.025604261085391045,
-0.011949455365538597,
-0.01367882452905178,
-0.021989399567246437,
0.005590423941612244,
-0.03336239978671074,
0.01425528060644865,
-0.06321802735328674,
-0.009169255383312702,
-0.010562358424067497,
0.016428999602794647,
-0.031176671385765076,
-0.03223350644111633,
0.05740542709827423,
-0.007746129762381315,
-0.0054643237963318825,
-0.0324256606400013,
-0.04597237706184387,
0.034323159605264664,
0.04217737540602684,
0.0395352840423584,
-0.00556039996445179,
0.020115917548537254,
0.034875597804784775,
0.0085327522829175,
0.011427042074501514,
-0.0015777484513819218,
-0.030528157949447632,
0.013606767170131207,
-0.03158499300479889,
-0.037877973169088364,
-0.01945539563894272,
0.003653891384601593,
0.01367882452905178,
-0.043138135224580765,
-0.041672974824905396,
-0.030023757368326187,
0.025820432230830193,
-0.0223977230489254,
0.008748923428356647,
-0.00496292719617486,
0.011463071219623089,
0.0501997247338295,
-0.02171318233013153,
0.039199016988277435,
-0.03847844898700714,
0.04981542006134987,
-0.004809806123375893,
-0.019035061821341515,
-0.058654412627220154,
0.017353732138872147,
-0.02586846984922886,
0.02007989026606083,
0.017593922093510628,
-0.027693914249539375,
0.026613058522343636,
-0.014003081247210503,
-0.04222541302442551,
0.0037349555641412735,
0.024079054594039917,
-0.026132678613066673,
0.01945539563894272,
-0.02161710523068905,
0.04726940393447876,
-0.001000541727989912,
-0.028366446495056152,
0.055724095553159714,
0.0233945120126009,
0.01127692312002182,
0.0016798293218016624,
-0.009013132192194462,
-0.014819727279245853,
0.007596010807901621,
0.04642874002456665,
0.006929483264684677,
0.0029213116504251957,
-0.009955878369510174,
0.03129676729440689,
-0.0036028509493917227,
0.05116048455238342,
-0.02094457298517227,
-0.008256533183157444,
-0.03353053331375122,
-0.032545752823352814,
-0.012453855015337467,
0.0032425657846033573,
0.02056027017533779,
0.01700545661151409,
-0.01417121384292841,
0.04433908686041832,
0.007121635600924492,
-0.012646007351577282,
0.017629951238632202,
0.03168106824159622,
0.035259902477264404,
0.04208130016922951,
0.04772576689720154,
-0.06432289630174637,
0.028630655258893967,
0.010033939965069294,
0.01615278236567974,
-0.0610082782804966,
-0.028750751167535782,
0.018410569056868553,
0.026709135621786118,
0.008166462182998657,
0.055820170789957047,
-0.034034933894872665,
-0.026613058522343636,
0.005380257498472929,
-0.0011656724382191896,
0.041360728442668915,
0.06023966893553734,
0.05221731960773468,
-0.021977391093969345,
-0.05365845933556557,
-0.006473122164607048,
-0.036196641623973846,
0.010304153896868229,
-0.03345847502350807,
0.020992612466216087,
-0.005013967398554087,
0.03566822409629822,
-0.044915542006492615,
-0.005086024757474661,
0.027093440294265747,
0.03343445807695389,
-0.01161919441074133,
0.0538986511528492,
-0.016044696792960167,
-0.0605759359896183,
0.01062841061502695,
-0.03876667469739914,
0.10145628452301025,
-0.0011303945211693645,
-0.05447510629892349,
0.0031795159447938204,
-0.001171677140519023,
-0.012285721488296986,
0.003353653708472848,
0.02186930552124977,
0.011517114005982876,
-0.011631203815340996,
-0.022373704239726067,
0.02805420011281967,
0.0503438375890255,
-0.0007385844364762306,
-0.0032485707197338343,
-0.018746834248304367,
0.01483173668384552,
-0.04911886900663376,
0.03081638552248478,
-0.04729342460632324,
0.01845860667526722,
0.027165496721863747,
0.012417826801538467,
-0.0016588126309216022,
-0.020332088693976402,
-0.012850168161094189,
-0.0037499673198908567,
-0.016320914030075073,
0.022037439048290253,
-0.04467535391449928,
-0.021124716848134995,
0.013114377856254578,
-0.0012099574087187648,
-0.031633030623197556,
0.02634884975850582,
-0.023754797875881195,
-0.010772524401545525,
0.03408297151327133,
-0.04883063957095146,
-0.018674777820706367,
-0.018566692247986794,
0.04044800624251366,
0.03562018647789955,
-0.005386262200772762,
-0.004182309377938509,
-0.009001122787594795,
0.036797117441892624,
0.029879644513130188,
-0.017521865665912628,
0.01675325632095337,
-0.02603660337626934,
0.04784586280584335,
-0.0305041391402483,
0.019419366493821144,
0.03831031545996666,
-0.006995535455644131,
0.03192126005887985,
0.01644100993871689,
0.0056084380485117435,
0.030095815658569336,
-0.0032395634334534407,
-0.0035007703118026257,
-0.021905334666371346,
-0.04474740847945213,
-0.030408062040805817,
0.028246352449059486,
0.06614834070205688,
-0.0250278040766716,
0.07354620099067688,
-0.012075555510818958,
0.030336005613207817,
-0.04056810215115547,
-0.002377881668508053,
0.01621283032000065,
-0.010562358424067497,
0.015972638502717018,
0.008899042382836342,
0.010904628783464432,
0.0029138056561350822,
-0.003266584826633334,
-0.001691838726401329,
0.0013262995053082705,
0.011445056647062302,
0.02063232660293579,
0.009745711460709572,
0.04897475615143776,
0.03377072140574455,
0.015059917233884335,
0.016669191420078278,
-0.01371485274285078,
0.005689502228051424,
0.003320627612993121,
-0.035572148859500885,
0.013654804788529873,
-0.014375375583767891,
-0.03698927164077759,
-0.007517949212342501,
-0.02788606658577919,
-0.022373704239726067,
-0.01474766992032528,
0.009943868964910507,
-0.027285590767860413,
0.02248178981244564,
-0.0177020076662302,
0.007986319251358509,
0.03321828693151474,
-0.007596010807901621,
-0.0538986511528492,
-0.09232906252145767,
-0.037901993840932846,
-0.04474740847945213,
0.03970341756939888,
-0.001992076402530074,
0.010286139324307442,
0.014183223247528076,
-0.038430411368608475,
-0.010412239469587803,
-0.006773360073566437,
-0.0028177297208458185,
-0.012141607701778412,
-0.029399264603853226,
-0.004695715848356485,
0.0012760097160935402,
-0.002727658487856388,
0.00869488064199686,
0.017329713329672813,
0.0248836912214756,
0.013726862147450447,
-0.023274417966604233,
-0.00012600596528500319,
0.001289520412683487,
0.03377072140574455,
0.004806803539395332,
-0.0008181473822332919,
-0.01584053412079811,
0.003981150221079588,
0.021989399567246437,
-0.016885360702872276,
-0.019527452066540718,
0.029087016358971596,
-0.028558598831295967,
-0.031224709004163742,
0.012874187901616096,
0.032329581677913666,
0.0010230595944449306,
0.01892697624862194,
0.03970341756939888,
-0.004269378259778023,
0.010136020369827747,
-0.014027100056409836,
0.023502597585320473,
-0.046765007078647614,
-0.005365245509892702,
-0.0012542424956336617,
0.0008751925779506564,
0.03691721335053444,
0.012670026160776615,
-0.0085327522829175,
0.01946740411221981,
-0.019179176539182663,
-0.03458736836910248,
0.007794167846441269,
-0.01838655024766922,
-0.0011499099200591445,
0.024055035784840584,
-0.0430900976061821,
0.009577578864991665,
-0.012766102328896523,
0.007121635600924492,
0.007481920532882214,
0.030936479568481445,
0.020416155457496643,
-0.009217293933033943,
0.041913166642189026,
0.020668355748057365,
-0.042849909514188766,
0.03746965155005455,
-0.008947080001235008,
-0.00016119005158543587,
-0.04357047751545906,
-0.015143983997404575,
0.005752551835030317,
0.0015267081325873733,
0.016020677983760834,
0.00554238585755229,
-0.020428165793418884,
0.04342636466026306,
0.029014959931373596,
-0.020800460129976273,
-0.013462653383612633,
0.009823773987591267,
0.019899746403098106,
0.03521186485886574,
-0.019875727593898773,
0.007541968021541834,
0.0038490458391606808,
0.023502597585320473,
-0.035043731331825256,
-0.03586037829518318,
0.0249557476490736,
0.001682831672951579,
0.007229721173644066,
-0.005470328964293003,
0.005046993959695101,
0.005611440632492304,
0.003368665697053075,
-0.05423491820693016,
0.013618776574730873,
0.018806882202625275,
0.03537999838590622,
-0.003801007755100727,
-0.02086050808429718,
-0.03758974373340607,
-0.019911756739020348,
0.03775787726044655,
0.011451061815023422,
-0.03821424022316933,
0.029567396268248558,
-0.025051824748516083,
-0.012597968801856041,
-0.008274547755718231,
0.003047411562874913,
0.041360728442668915,
-0.010406234301626682,
-0.027069419622421265,
-0.005794585216790438,
-0.043378327041864395,
0.011270918883383274,
-0.014675612561404705,
0.028678694739937782,
-0.024979766458272934,
-0.019983813166618347,
0.0016377960564568639,
0.06331410259008408,
0.018398558720946312,
0.014699632301926613,
-0.037901993840932846,
-0.03660496696829796,
-0.015576325356960297,
0.034275121986866,
0.037901993840932846,
-0.02063232660293579,
0.024307234212756157,
-0.02015194669365883,
-0.031464897096157074,
-0.005221131723374128,
-0.0014433921314775944,
0.006455108057707548,
-0.0014869265723973513,
0.016813304275274277,
0.03036002442240715,
0.09333785623311996,
-0.001172427786514163,
0.04904681071639061,
0.00631699850782752,
-0.005107041448354721,
-0.014519489370286465,
0.008106415160000324,
0.02084849774837494,
-0.005236143246293068,
0.018518654629588127,
-0.025892488658428192,
-0.008598804473876953,
-0.03189723938703537,
-0.00004496526889852248,
-0.013882985338568687,
0.01367882452905178,
0.012754092924296856,
-0.006076808553189039,
-0.03381876274943352,
-0.03112863190472126,
0.011150823906064034,
-0.01417121384292841,
0.008418661542236805,
0.011577161028981209,
0.023766806349158287,
-0.004449521191418171,
-0.0008819478680379689,
-0.002109169028699398,
-0.03244967758655548,
-0.017269665375351906,
0.025988565757870674,
-0.001230974099598825,
0.03761376440525055,
0.00877294223755598,
-0.015192021615803242,
-0.004500561393797398,
-0.034179046750068665,
-0.0037769887130707502,
0.008508733473718166,
0.012369788251817226,
0.003476751269772649,
0.04044800624251366,
-0.0467890240252018,
-0.04078427329659462,
-0.017365742474794388,
0.014315327629446983,
-0.029927682131528854,
0.02872673235833645,
-0.00565947825089097,
-0.01677727699279785,
-0.014027100056409836,
-0.001363078597933054,
-0.04008772224187851,
-0.03153695538640022,
0.03638879582285881,
0.006617236416786909,
-0.022109495475888252,
0.042129337787628174,
-0.04462731257081032,
0.014615565538406372,
-0.010406234301626682,
-0.01293423492461443,
-0.022842075675725937,
-0.02030806988477707,
-0.010376211255788803,
0.020512230694293976,
0.009097198955714703,
0.014663603156805038,
0.014279299415647984,
0.0042603714391589165,
0.005527373868972063,
-0.025219956412911415,
-0.021376915276050568,
0.0012827650643885136,
-0.023082265630364418,
0.007884238846600056,
0.012537921778857708,
0.002290812786668539,
-0.011973475106060505,
0.002799715381115675,
0.023418530821800232,
0.009469493292272091,
-0.029999738559126854,
-0.013150406070053577,
0.013150406070053577,
-0.005440304987132549,
0.007680077571421862,
0.04333028942346573,
-0.050872255116701126,
-0.013186434283852577,
0.013126387260854244,
0.023382503539323807,
-0.0134386345744133,
-0.008262538351118565,
-0.03499569371342659,
0.0033266323152929544,
-0.009121217764914036,
0.004338433034718037,
0.0336986668407917,
0.02278202772140503,
-0.04126465320587158,
-0.010940657928586006,
0.017942197620868683,
-0.011439051479101181,
0.014111165888607502,
0.009067174978554249,
-0.010940657928586006,
-0.03941518813371658,
-0.003515782067552209,
0.022445762529969215,
-0.02478761412203312,
0.013738871552050114,
0.014651593752205372,
0.027333630248904228,
-0.005434300284832716,
0.01034618727862835,
0.021965380758047104,
0.010454272851347923,
-0.019035061821341515,
0.005227136425673962,
0.00373795791529119,
0.01738976128399372,
-0.03461138904094696,
0.03192126005887985,
0.022998198866844177,
-0.017017466947436333,
0.010148030705749989,
-0.11769313365221024,
-0.010652429424226284,
-0.017161579802632332,
-0.006707307416945696,
-0.025820432230830193,
0.018518654629588127,
0.010880609974265099,
0.029399264603853226,
-0.010640420019626617,
-0.02093256451189518,
0.000021743768229498528,
-0.005809597205370665,
0.012730073183774948,
-0.009175260551273823,
0.006953502539545298,
-0.017978226765990257,
0.008544761687517166,
-0.029471321031451225,
-0.02534005232155323,
-0.020356107503175735,
0.004830822814255953,
0.017269665375351906,
-0.01844659633934498,
0.03646085038781166,
-0.007403858937323093,
-0.005389264784753323,
-0.011757303960621357,
-0.010916638188064098,
-0.01012401096522808,
-0.003030898282304406,
0.044363103806972504,
0.029615435749292374,
-0.02889486402273178,
0.026901287958025932,
0.0023703756742179394,
-0.005302195902913809,
0.005359240807592869,
0.007523953914642334,
0.01000992115586996,
-0.02263791300356388,
0.009739707224071026,
0.002068636938929558,
0.005980732850730419,
-0.004374461714178324,
-0.009703679010272026,
-0.004038195591419935,
-0.025075843557715416,
-0.0029393259901553392,
0.04798997566103935,
-0.014075137674808502,
-0.012369788251817226,
-0.048782601952552795,
-0.027693914249539375,
-0.00019140145741403103,
0.007481920532882214,
-0.00787823460996151,
-0.008292562328279018,
-0.006887450348585844,
0.01567240245640278,
-0.0011551640927791595,
0.022685952484607697,
0.038430411368608475,
0.021965380758047104,
-0.003770984010770917,
-0.020512230694293976,
-0.012117588892579079,
-0.00311046140268445,
0.02656502090394497,
-0.04928700253367424,
0.00918726995587349,
-0.005308200605213642,
0.015083936043083668,
-0.03511578589677811,
0.014699632301926613,
0.02248178981244564,
-0.017257656902074814,
0.0044224997982382774,
0.0006901711458340287,
-0.03730151802301407,
0.0018764848355203867,
0.018422577530145645,
0.0020175965037196875,
-0.031176671385765076,
0.008106415160000324,
-0.018194397911429405,
0.006037777755409479,
0.005176095757633448,
0.022541837766766548,
-0.00309845176525414,
0.02819831296801567,
-0.004458528012037277,
-0.013354567810893059,
-0.0038040101062506437,
-0.0062209228053689,
-0.018050283193588257,
-0.030215909704566002,
-0.011445056647062302,
-0.00996788777410984,
0.00915124174207449,
0.0009037151467055082,
0.0134386345744133,
-0.02663707733154297,
-0.013967052102088928,
-0.010808552615344524,
0.02208547666668892,
-0.010406234301626682,
0.03425110504031181,
-0.021665144711732864,
0.0071336450055241585,
-0.01784612238407135,
0.040520064532756805,
0.0063530271872878075,
0.03362660855054855,
-0.0018089314689859748,
-0.014735660515725613,
0.02841448411345482,
0.0028867842629551888,
-0.043834686279296875,
0.009079184383153915,
-0.007656058296561241,
0.029159074649214745,
0.021112706512212753,
0.010574367828667164,
0.007217711303383112,
-0.03883873298764229,
-0.006292979698628187,
0.00564146414399147,
0.027621857821941376,
-0.02990366332232952,
0.010166044346988201,
0.004167297855019569,
0.02903897874057293,
-0.01074250042438507,
-0.002991867484524846,
0.014303318224847317,
-0.009361407719552517,
-0.02309427410364151,
0.023286426439881325,
0.012069550342857838,
0.001137900399044156,
-0.027213534340262413,
0.012405816465616226,
0.026012584567070007,
0.0030218912288546562,
0.02107667736709118,
0.014351356774568558,
-0.017281675711274147,
0.03823825716972351,
-0.03249771520495415,
0.00918726995587349,
0.016188809648156166,
0.022121505811810493,
0.018818892538547516,
0.04517975077033043,
0.006911469157785177,
-0.009691668674349785,
0.01660914346575737,
-0.014567527920007706,
-0.004914889112114906,
0.03196929767727852,
0.010658434592187405,
0.019719604402780533,
-0.03249771520495415,
-0.036653004586696625,
0.001780408900231123,
-0.033338382840156555,
0.010214082896709442,
0.019107120111584663,
-0.011559146456420422,
-0.0016302900621667504,
0.017858130857348442,
-0.0497673824429512,
0.0324256606400013,
-0.013210454024374485,
0.012129598297178745,
0.03903088718652725,
-0.00309845176525414,
0.00003982839189120568,
0.01699344627559185,
0.03770983964204788,
-0.002736665541306138,
0.026300812140107155,
0.010039945133030415,
-0.0005265416693873703,
0.018650759011507034,
0.006503146141767502,
0.00003180641942890361,
0.015240059234201908,
0.0570211224257946,
-0.032017335295677185,
-0.0047887894324958324,
0.01815836876630783,
0.04448319971561432,
0.02455943450331688,
0.04169699549674988,
-0.02827037125825882,
-0.03701328858733177,
0.03134480491280556,
-0.02310628443956375,
-0.03497167304158211,
-0.019899746403098106,
0.057981882244348526,
0.052025169134140015,
0.0004604893911164254,
-0.01668119989335537,
0.031945277005434036,
0.032641828060150146,
-0.020980602130293846,
-0.021881315857172012,
0.07100018113851547,
-0.007890244014561176,
0.02394695021212101,
-0.016428999602794647,
0.02200140990316868,
0.00029592166538350284,
-0.023286426439881325,
0.013931023888289928,
0.009145236574113369,
-0.04176905378699303,
-0.021569067612290382,
-0.024055035784840584,
-0.04316215589642525,
0.04796595498919487,
0.007746129762381315,
0.00919327512383461,
-0.028918884694576263,
0.03516382724046707,
0.02023601345717907,
-0.02666109800338745,
0.043306268751621246,
0.0038520481903105974,
0.03136882185935974,
0.055195678025484085,
-0.003113463753834367,
-0.03506774827837944,
-0.015216040425002575,
0.013126387260854244,
-0.017269665375351906,
-0.02742970548570156,
0.007602015510201454,
0.03098451904952526,
0.004797796718776226,
-0.022385714575648308,
-0.01298227347433567,
-0.004803801421076059,
0.010796543210744858,
0.038046106696128845,
-0.03883873298764229,
-0.016008667647838593,
-0.05231339484453201,
-0.015636373311281204,
-0.016284886747598648,
0.028558598831295967,
0.03694123029708862,
0.03081638552248478,
0.03206537291407585,
-0.024739576503634453,
0.020175965502858162,
0.038814716041088104,
-0.017954207956790924,
-0.022818056866526604,
0.0023403519298881292,
-0.021653134375810623,
0.016104744747281075,
-0.002957340097054839,
0.02457144297659397,
0.02024802193045616,
0.005173093639314175,
0.023670731112360954,
0.0223256666213274,
0.005146072246134281,
-0.012381797656416893,
-0.004335430450737476,
-0.015155993402004242,
-0.012267707847058773,
-0.031993318349123,
0.029399264603853226,
-0.025051824748516083,
-0.007794167846441269,
0.0268772691488266,
0.012561940588057041,
0.004893872421234846,
-0.04241756722331047,
0.010232096537947655,
0.00550335505977273,
-0.009139232337474823,
-0.01746181771159172,
-0.03855050727725029,
-0.0035007703118026257,
-0.008562776260077953,
-0.026709135621786118,
0.03770983964204788,
-0.037901993840932846,
-0.0028522571083158255,
0.024115081876516342,
-0.026709135621786118,
-0.0005374252796173096,
0.005830613896250725,
0.002271297387778759,
-0.018566692247986794,
-0.013354567810893059,
-0.006653264630585909,
-0.014099156484007835,
-0.0023523615673184395,
-0.01790616847574711,
-0.04018379747867584,
-0.023370493203401566,
-0.03338642045855522,
0.010051954537630081,
0.01293423492461443,
-0.02742970548570156,
0.007055582944303751,
0.013618776574730873,
0.012345769442617893,
0.0336986668407917,
-0.0017488838639110327,
-0.00610082782804966,
0.010844581760466099,
-0.01181735098361969,
-0.018434587866067886,
0.030167872086167336,
0.03172910585999489,
-0.005884656682610512,
-0.0033386419527232647,
-0.016020677983760834,
-0.031392842531204224,
0.0161407720297575,
0.012682035565376282,
-0.03756572678685188,
-0.008274547755718231,
-0.0016107746632769704,
-0.0009885322069749236,
-0.03593243286013603,
0.004581625573337078,
0.005653473548591137,
0.022061457857489586,
0.004911886993795633,
-0.006347022484987974,
0.021040650084614754,
0.016320914030075073,
0.013246482238173485,
-0.01891496777534485,
-0.0009532543481327593,
-0.0006492637912742794,
0.028702713549137115,
0.004806803539395332,
0.013234472833573818,
0.002564028836786747,
-0.021112706512212753,
0.009481502696871758,
0.05682896822690964,
-0.0033506513573229313,
-0.031224709004163742,
-0.0006849169731140137,
-0.007361825555562973,
-0.0034106988459825516,
0.005806594621390104,
-0.00012488006905186921,
-0.03713338449597359,
0.027405686676502228,
-0.014615565538406372,
0.0125139020383358,
0.019515443593263626,
0.013126387260854244,
0.022733990103006363,
-0.013834947720170021,
-0.005887658800929785,
-0.0354040153324604,
0.016741247847676277,
-0.01224368903785944,
0.00992585439234972,
0.03946322947740555,
-0.009247317910194397,
-0.01158316619694233,
-0.026709135621786118,
0.007199697196483612,
0.0426577553153038,
-0.02131686918437481,
0.02410307340323925,
0.012706054374575615,
-0.005242147948592901,
-0.013078348711133003,
-0.0010410738177597523,
-0.025051824748516083,
-0.0060828132554888725,
-0.0038820719346404076,
-0.014099156484007835,
-0.033938854932785034,
0.01945539563894272,
0.004224342759698629,
-0.02347857877612114,
0.02246978133916855,
0.014051118865609169,
0.02959141694009304,
-0.017714018002152443,
0.005110043566673994,
0.043834686279296875,
0.010136020369827747,
-0.010616401210427284,
0.002658603712916374,
0.0026150692719966173,
0.03043208085000515,
0.01177531760185957,
-0.013258491642773151,
-0.007253739982843399,
-0.01115682814270258,
0.007217711303383112,
0.04570816829800606,
-0.011024723760783672,
0.024451348930597305,
-0.05625251308083534,
0.02023601345717907,
-0.01916716806590557,
0.008905046619474888,
0.024199148640036583,
-0.014507479965686798,
-0.01992376521229744,
0.012862177565693855,
-0.02594052627682686,
0.05207320675253868,
0.0008264039643108845,
0.00685742637142539,
0.00026946322759613395,
0.0049329036846756935,
-0.020884526893496513,
-0.01714957132935524,
0.008010338991880417,
0.0029062998946756124,
-0.006701302714645863,
0.03425110504031181,
0.005049996078014374,
-0.0389588288962841,
0.0408082939684391,
0.019527452066540718,
-0.012261702679097652,
-0.0055694072507321835,
-0.010670443996787071,
0.018554681912064552,
-0.03936715051531792,
0.04131269082427025,
0.020500222221016884,
0.027237553149461746,
0.017089523375034332,
0.0016062710201367736,
-0.005031981971114874,
-0.0012609978439286351,
-0.02781401015818119,
-0.030384043231606483,
0.03991958871483803,
-0.02063232660293579,
-0.005809597205370665,
0.027285590767860413,
-0.032641828060150146,
0.001339059672318399,
-0.01540819276124239,
-0.025292014703154564,
-0.021569067612290382,
-0.025388089939951897,
0.016945408657193184,
0.01885491982102394,
-0.03220948949456215,
0.01298227347433567,
0.0006372542702592909,
0.005728533025830984,
0.017966216430068016,
0.012585959397256374,
-0.03026394732296467,
0.0005190357333049178,
-0.011054747737944126,
0.028222331777215004,
-0.0020761429332196712,
0.0013007792877033353,
0.016861341893672943,
0.024619482457637787,
0.002712646499276161,
-0.00787823460996151,
-0.011565151624381542,
0.013907005079090595,
0.0016227841842919588,
-0.002173720160499215,
-0.023730779066681862,
0.01646502874791622,
0.0010170547757297754,
-0.016741247847676277,
0.02757382020354271,
0.017329713329672813,
-0.006058794446289539,
-0.02524397522211075,
0.026300812140107155,
-0.0027336631901562214,
-0.017641959711909294,
-0.010202073492109776,
-0.003398689441382885,
-0.03192126005887985,
0.0019035062287002802,
0.0003006128827109933,
0.013642795383930206,
-0.029183093458414078,
-0.0039361147210001945,
0.017822103574872017,
-0.009673655033111572,
-0.02056027017533779,
-0.011174842715263367,
-0.04073623567819595,
0.032281544059515,
0.00009992282139137387,
-0.02279403805732727,
0.005218129139393568,
-0.005674490239471197,
0.0005498100654222071,
0.007019554730504751,
-0.007908257655799389,
-0.010262120515108109,
0.027765970677137375,
0.01700545661151409,
-0.006995535455644131,
-0.03581233695149422,
0.031032556667923927,
-0.006923478562384844,
0.015059917233884335,
-0.012826149351894855,
0.031873222440481186,
0.011637208983302116,
-0.041600920259952545,
-0.02882280759513378,
-0.006581207737326622,
-0.0085687804967165,
0.016260867938399315,
0.008424666710197926,
0.013798919506371021,
0.020115917548537254,
-0.019179176539182663,
0.03605252876877785,
0.005284181330353022,
-0.020716393366456032,
0.05947105959057808,
0.023982977494597435,
-0.005707516334950924,
-0.015660392120480537,
-0.009457483887672424,
-0.01669321022927761,
0.001667819800786674,
0.03840639069676399,
-0.01317442487925291,
0.005800589919090271,
-0.012754092924296856,
0.017029475420713425,
-0.01088661514222622,
0.0098838210105896,
0.012117588892579079,
0.020524241030216217,
-0.025195937603712082,
0.046765007078647614,
0.011883403174579144,
-0.02882280759513378,
-0.043834686279296875,
-0.009175260551273823,
-0.0045696161687374115,
-0.022529827430844307,
0.007920267060399055,
0.02927916869521141,
-0.01239380706101656,
-0.018122339621186256,
-0.008004333823919296,
0.01054434385150671,
0.019515443593263626,
-0.01355872955173254,
0.003260580124333501,
-0.05413883924484253,
0.035644207149744034,
0.03336239978671074,
-0.019587500020861626,
-0.00795629620552063,
-0.015780488029122353,
-0.04056810215115547,
0.028918884694576263,
-0.0018944991752505302,
0.011535127647221088,
0.009205284528434277,
-0.011643213219940662,
-0.04760567098855972,
0.006088817957788706,
-0.04176905378699303,
-0.0027201524935662746,
0.026781192049384117,
0.020656345412135124,
-0.012429836206138134,
-0.03689319267868996,
-0.014723651111125946,
0.00550335505977273,
0.0098477927967906,
-0.012694044969975948,
-0.03984753042459488,
-0.02935122512280941,
-0.0021782235708087683,
0.028558598831295967,
0.009169255383312702,
-0.011330965906381607,
-0.022229591384530067,
-0.000750218634493649,
-0.006545179057866335,
0.010892619378864765,
0.013366577215492725,
-0.001947040669620037,
0.0040442002937197685,
-0.02764587663114071,
-0.021521029993891716,
-0.05995143949985504,
-0.01939534768462181,
0.03713338449597359,
-0.023910921066999435,
0.0025625277776271105,
0.004434509202837944,
0.024691538885235786,
0.0006650262512266636,
0.029951700940728188,
-0.04786987975239754,
0.020668355748057365,
0.011487090028822422,
0.0012069550575688481,
0.029471321031451225,
0.049335040152072906,
-0.0212568212300539,
0.000662023841869086,
-0.0393911711871624,
0.049863457679748535,
-0.03691721335053444,
-0.007115630898624659,
-0.0015237057814374566,
0.0018719813087955117,
-0.027285590767860413,
-0.003653891384601593,
-0.03374670445919037,
-0.020187975838780403,
0.001858470612205565,
0.016645170748233795,
-0.02603660337626934,
0.01814636029303074,
-0.019287262111902237,
-0.002540010027587414,
-0.02889486402273178,
0.029327206313610077,
-0.005722528323531151,
0.009103203192353249,
-0.016501057893037796,
0.03211341053247452,
-0.017858130857348442,
-0.024907710030674934,
-0.01050831563770771,
-0.04172101616859436,
-0.008388638496398926,
0.005119050852954388,
-0.019791660830378532,
0.010670443996787071,
0.008214499801397324,
0.0392470583319664,
-0.00027546798810362816,
-0.0004188314196653664,
-0.042585697025060654,
-0.009325379505753517,
0.017509855329990387,
-0.028558598831295967,
0.01853066310286522,
0.029399264603853226,
0.006019763648509979,
0.02078844979405403,
0.03470746427774429,
0.01471164170652628,
-0.016176801174879074,
0.023526616394519806,
-0.0017578910337761045,
-0.021220792084932327,
-0.03713338449597359,
0.008953084237873554,
0.055195678025484085,
-0.00619690353050828,
0.0034947653766721487,
0.023202359676361084,
-0.016957418993115425,
-0.0030083805322647095,
0.0016272877110168338,
0.021521029993891716,
0.04779782146215439,
-0.02735764905810356,
0.015792496502399445,
0.019755633547902107,
0.03276192396879196,
0.025556223466992378,
0.01483173668384552,
-0.015552306547760963,
-0.01622483879327774,
0.02016395516693592,
-0.0015927603235468268,
-0.009655640460550785,
0.0026405896060168743,
0.03963135927915573,
-0.015300107188522816,
0.022361695766448975,
0.005749549716711044,
0.002197739202529192,
-0.012093570083379745,
-0.008893037214875221,
-0.005587421357631683,
-0.006581207737326622,
0.011517114005982876,
0.006959507241845131,
-0.00424535945057869,
-0.06268960982561111,
0.007800172548741102,
0.0305041391402483,
-0.03329034149646759,
0.0037229459267109632,
-0.026060622185468674,
0.019119128584861755,
-0.004104247782379389,
0.03708534687757492,
0.03708534687757492,
0.0017969219479709864,
0.02579641342163086,
0.013366577215492725,
-0.01791817881166935,
0.00044960578088648617,
0.03036002442240715,
-0.014543508179485798,
0.016897371038794518,
-0.03439521789550781,
0.021268829703330994,
-0.004062214400619268,
0.016957418993115425,
-0.023502597585320473,
0.016332924365997314,
-0.022806046530604362,
0.0008571782964281738,
-0.02911103516817093,
-0.05043991282582283,
0.010880609974265099,
-0.008394642733037472,
-0.006545179057866335,
0.002068636938929558
] | 2024-07-05 | 72 | 38968149 | [
"nonhematopoietic cells",
"mature B cells",
"abnormal progenitor B cells",
"high hyperdiploidy cells",
"normal pro-B cells",
"B-cell progenitor acute lymphoblastic leukemia",
"chimeric antigen receptor T cells",
"subtypes",
"BCP",
"favorable outcomes",
"multimodal single-cell",
"myeloid marker CD371",
"the ALL cells",
"T-cell lineages",
"DUX4-r blasts",
"maturation arrest",
"DUX4-r ALL cells",
"transcriptional signatures",
"multiple genetic alterations",
"ALL",
"new therapeutic strategies",
"therapeutic vulnerabilities",
"side effects",
"Current treatment protocols",
"significant toxicity",
"PI3K inhibition",
"the cells",
"aberrant expression",
"myeloid",
"the DUX4-r subtype"
] | [] | 0 | 10.1182/blood.2023021705 | [
"Thorsson",
"Henningsson",
"Puente-Moncada",
"Peña-Martínez",
"Sjöström",
"Ågerstam",
"Sandén",
"Rissler",
"Castor",
"Marquart",
"Modvig",
"Paulsson",
"Pronk",
"Schmiegelow",
"Hyrenius-Wittsten",
"Orsmark-Pietras",
"Lilljebjörn",
"Fioretos"
] | [
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.\nDepartment of Clinical Genetics, Pathology and Molecular Diagnostics, Office for Medical Services, Region Skåne, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Childhood Cancer Center, Skåne University Hospital, Lund, Sweden.",
"Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.\nDepartment of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.",
"Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.\nDepartment of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Childhood Cancer Center, Skåne University Hospital, Lund, Sweden.",
"Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.\nDepartment of Pediatrics and Adolescent Medicine, The Juliane Marie Centre, University Hospital Rigshospitalet, Copenhagen, Denmark.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.\nDepartment of Clinical Genetics, Pathology and Molecular Diagnostics, Office for Medical Services, Region Skåne, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.",
"Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.\nDepartment of Clinical Genetics, Pathology and Molecular Diagnostics, Office for Medical Services, Region Skåne, Lund, Sweden."
] | [
"38968149",
"28297628",
"15071128",
"36050548",
"33054110",
"25435111",
"20876426",
"25317870",
"33558546",
"35767897",
"35732829",
"28778863",
"27265895",
"27776115",
"27019113",
"27903527",
"33318611",
"29608179",
"34725479",
"29228172",
"8231254",
"33910981",
"31178118",
"34062119",
"7564526",
"12094248",
"24530057",
"30388456",
"29942094",
"30814730",
"35750052",
"30595452",
"28622514",
"32323265",
"30951143",
"16199517",
"34788843",
"34916492",
"32333246",
"30669372",
"36243847",
"25759025",
"26847027",
"32646889",
"25148023",
"33147449",
"31014360",
"17609428",
"30705095",
"32415257",
"33218352",
"34304246",
"35145224",
"35288693",
"34864916",
"32470390",
"35275990",
"32203137",
"30635636",
"34365737",
"29505032",
"34824268",
"23471221",
"22209328",
"21060811",
"26907630",
"29316944",
"28676343",
"32435621",
"33832948",
"36151140",
"35799191"
] | [] | 6.530939 | 6.449343 |
38968138 | 758 | A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia. | Although chimeric antigen receptor (CAR) T-cell (CAR-T) therapy has revolutionized the treatment of B-cell malignancies, many patients relapse and therefore strategies to improve antitumor immunity are needed. We previously designed a novel autologous bispecific CAR targeting CD19 and CD22 (CAR19-22), which was well tolerated and associated with high response rates but relapse was common. Interleukin-15 (IL15) induces proliferation of diverse immune cells and can augment lymphocyte trafficking. Here, we report the results of a phase 1 clinical trial of the first combination of a novel recombinant polymer-conjugated IL15 receptor agonist (NKTR-255), with CAR19-22, in adults with relapsed/refractory B-cell acute lymphoblastic leukemia. Eleven patients were enrolled, 9 of whom successfully received CAR19-22 followed by NKTR-255. There were no dose-limiting toxicities, with transient fever and myelosuppression as the most common possibly related toxicities. We observed favorable efficacy with 8 of 9 patients (89%) achieving measurable residual disease-negative remission. At 12 months, progression-free survival for NKTR-255 was double that of historical controls (67% vs 38%). We performed correlative analyses to investigate the effects of IL15 receptor agonism. Cytokine profiling showed significant increases in IL15 and the chemokines CXCL9 and CXCL10. The increase in chemokines was associated with decreases in absolute lymphocyte counts and CD8+ CAR T cells in the blood and 10-fold increases in cerebrospinal fluid CAR-T cells, suggesting lymphocyte trafficking to tissue. Combining NKTR-255 with CAR19-22 was safe, feasible, and associated with high rates of durable responses. This trial was registered at www.clinicaltrials.gov as #NCT03233854. | [
0.022409534081816673,
0.026474298909306526,
0.025360340252518654,
0.02687722072005272,
-0.03311064839363098,
-0.021935509517788887,
-0.023653849959373474,
0.017669282853603363,
0.01004933100193739,
-0.010641862638294697,
-0.014149647206068039,
-0.03161747008562088,
-0.04669146612286568,
-0.00395218376070261,
0.02363014779984951,
-0.04953561723232269,
0.0302427988499403,
0.007661429699510336,
-0.011868402361869812,
0.04479536786675453,
0.020335674285888672,
0.031380459666252136,
-0.013154194690287113,
0.0031167147681117058,
-0.005670524667948484,
-0.04052914306521416,
0.008052500896155834,
0.014019290916621685,
-0.009634559042751789,
-0.049772631376981735,
0.030598316341638565,
-0.01983794756233692,
-0.006737080868333578,
-0.00010332264355383813,
-0.01300013717263937,
0.026782415807247162,
0.05280638858675957,
-0.008876118808984756,
-0.019707592204213142,
-0.031024938449263573,
0.05005704611539841,
-0.00607344601303339,
0.03981810435652733,
0.09058618545532227,
-0.05802066624164581,
-0.015713930130004883,
0.005519429221749306,
-0.041666802018880844,
0.02429378405213356,
-0.01618795469403267,
-0.030385006219148636,
-0.005966790486127138,
-0.03337136283516884,
0.03673694282770157,
-0.03239961341023445,
0.058636900037527084,
-0.0104404017329216,
0.008408019319176674,
-0.005791993346065283,
-0.004802466370165348,
0.013960037380456924,
-0.02799117937684059,
0.039746999740600586,
-0.026023974642157555,
-0.057641446590423584,
-0.024649301543831825,
-0.05565053969621658,
-0.03135675564408302,
0.022682098671793938,
0.009474575519561768,
-0.002324203960597515,
0.009978227317333221,
0.01123439334332943,
0.011400301940739155,
0.02288355864584446,
0.038704145699739456,
-0.0020842289086431265,
-0.0016901955241337419,
0.012075788341462612,
-0.010807771235704422,
0.00039921796997077763,
0.005356483161449432,
0.015619125217199326,
-0.05806806683540344,
0.011820999905467033,
-0.010641862638294697,
0.02732754312455654,
-0.04548270255327225,
-0.03045610897243023,
0.017752237617969513,
-0.003809976391494274,
0.006034931167960167,
-0.04872977361083031,
0.03576518967747688,
-0.004414358176290989,
-0.008253960870206356,
-0.0031493038404732943,
-0.040292128920555115,
0.0427570603787899,
0.05157392472028732,
0.03984180465340614,
0.027351245284080505,
-0.011098111048340797,
-0.018167009577155113,
0.012632767669856548,
0.025312937796115875,
-0.039249274879693985,
0.01098553091287613,
0.0377797968685627,
-0.017195258289575577,
0.08745761960744858,
0.015156950801610947,
0.0008984255837276578,
0.02566845715045929,
-0.0030085777398198843,
-0.055271320044994354,
-0.02837039902806282,
-0.047947634011507034,
-0.0024664115626364946,
0.038917455822229385,
-0.053185611963272095,
0.02184070460498333,
0.03773239254951477,
-0.022824306041002274,
-0.02467300370335579,
-0.0352911651134491,
0.10333745926618576,
-0.010677414014935493,
-0.022741351276636124,
-0.0571674220263958,
0.03168857470154762,
0.023618297651410103,
0.023310182616114616,
-0.0018901749281212687,
-0.09148683398962021,
-0.008876118808984756,
-0.014469614252448082,
-0.03448532149195671,
-0.015548021532595158,
-0.026972025632858276,
0.016294611617922783,
-0.034390516579151154,
-0.044747963547706604,
0.007738458923995495,
-0.04972522705793381,
-0.04477166756987572,
0.009184235706925392,
0.0069681680761277676,
0.025739559903740883,
0.010701115243136883,
-0.02545514516532421,
0.05636157840490341,
0.0198853500187397,
0.012466859072446823,
-0.0034929721150547266,
-0.059347935020923615,
-0.04818464443087578,
0.04481906816363335,
-0.005637935362756252,
-0.033347662538290024,
-0.006470441818237305,
-0.0012583883944898844,
-0.04500867798924446,
-0.012360203079879284,
0.028773320838809013,
-0.0035137105733156204,
0.017337465658783913,
0.02853630855679512,
-0.07593881338834763,
0.01602204702794552,
-0.007459969259798527,
-0.027256440371274948,
-0.0778823122382164,
-0.04000771418213844,
-0.061386242508888245,
0.024862613528966904,
0.042164526879787445,
-0.0070392717607319355,
-0.03934407979249954,
0.008597629144787788,
-0.0031522666104137897,
0.009628633968532085,
0.024720406159758568,
-0.022848008200526237,
-0.05275898799300194,
0.011121812276542187,
-0.012774975039064884,
0.02979247458279133,
-0.04564861208200455,
0.025739559903740883,
0.0070748236030340195,
0.016898993402719498,
0.041714202612638474,
0.010274493135511875,
-0.01098553091287613,
-0.0066185747273266315,
0.0558401495218277,
0.030076889321208,
-0.058352481573820114,
-0.03557557985186577,
0.009658260270953178,
-0.027066830545663834,
-0.031972989439964294,
-0.02412787452340126,
-0.010410775430500507,
0.004675072152167559,
0.010689265094697475,
0.026640208438038826,
-0.0094034718349576,
-0.012046161107718945,
0.054275866597890854,
0.012715721502900124,
-0.006885213777422905,
0.028228191658854485,
-0.02903403341770172,
0.007377014961093664,
-0.028014879673719406,
0.03856193646788597,
0.022148819640278816,
0.02205401472747326,
0.006932616233825684,
-0.027683062478899956,
-0.022065866738557816,
-0.017147855833172798,
-0.019209865480661392,
-0.0056645991280674934,
0.034343115985393524,
-0.04197491705417633,
-0.02180515229701996,
-0.02479151077568531,
-0.0034751961939036846,
0.017621880397200584,
0.027469752356410027,
-0.027398647740483284,
-0.005214275326579809,
-0.01647237129509449,
0.04005511477589607,
0.0011887659784406424,
0.06731155514717102,
-0.007536998484283686,
-0.005830508191138506,
0.03460382670164108,
0.013948187232017517,
0.035836294293403625,
0.004242524039000273,
-0.011133663356304169,
-0.01426815427839756,
-0.07565439492464066,
-0.01038114819675684,
-0.004547677934169769,
-0.012277248315513134,
0.00902425218373537,
-0.014789581298828125,
-0.030645718798041344,
-0.0009976745350286365,
0.009154608473181725,
0.009444949217140675,
-0.03254181891679764,
-0.024744108319282532,
-0.0027789718005806208,
0.01214689202606678,
-0.013237149454653263,
-0.00946272537112236,
-0.03932037949562073,
-0.031475264579057693,
0.021769599989056587,
-0.015619125217199326,
0.04244894161820412,
-0.008905746042728424,
-0.01875954121351242,
0.011447705328464508,
-0.014457764104008675,
0.043539199978113174,
-0.025573652237653732,
-0.03514895588159561,
0.004799503833055496,
0.012300949543714523,
0.02391456440091133,
0.012241696938872337,
-0.005463138688355684,
-0.02238583378493786,
0.004061802290380001,
-0.04003141447901726,
-0.05432327091693878,
-0.009847870096564293,
-0.01429185550659895,
0.008686508983373642,
-0.0302427988499403,
-0.01185655128210783,
-0.04041063413023949,
-0.003525561187416315,
-0.01580873504281044,
-0.020608238875865936,
-0.026095079258084297,
-0.010641862638294697,
0.006417114287614822,
-0.012763123959302902,
-0.028891826048493385,
-0.01768113486468792,
0.03348986804485321,
-0.015583573840558529,
0.034390516579151154,
-0.004029212985187769,
-0.020193466916680336,
0.013118643313646317,
0.023570895195007324,
-0.016330162063241005,
0.0087813138961792,
0.012229845859110355,
0.06394597887992859,
0.05062587559223175,
0.0033359513618052006,
-0.00728220958262682,
0.0054246243089437485,
0.012964584864675999,
-0.016827888786792755,
0.04221193119883537,
-0.0584946908056736,
0.01514510065317154,
-0.006920765619724989,
-0.02304946817457676,
-0.007169628981500864,
-0.017313765361905098,
0.01073074247688055,
0.008810940198600292,
-0.021058563143014908,
0.01217059325426817,
-0.031427860260009766,
-0.0106477877125144,
-0.059727154672145844,
0.021236322820186615,
-0.06129143759608269,
0.05546092987060547,
-0.019209865480661392,
0.010748517699539661,
-0.007519222330302,
-0.05166872963309288,
-0.06920765340328217,
0.0594901442527771,
0.038633041083812714,
0.013628220185637474,
0.03981810435652733,
-0.03785090148448944,
0.034011296927928925,
0.01512139942497015,
0.009717513807117939,
0.030811628326773643,
0.00821840949356556,
0.0009287928114645183,
0.028820723295211792,
-0.017491525039076805,
0.005303155165165663,
0.0023271667305380106,
0.02595287188887596,
-0.016235357150435448,
0.004230673424899578,
-0.026023974642157555,
-0.015334710478782654,
0.005214275326579809,
0.02250433899462223,
0.002959693782031536,
0.018878048285841942,
-0.02450709417462349,
0.026308389380574226,
0.06261871010065079,
0.05162132903933525,
-0.028014879673719406,
0.05190574377775192,
-0.029768772423267365,
-0.02687722072005272,
-0.016247209161520004,
0.01751522533595562,
0.02808598428964615,
0.040671348571777344,
-0.018024802207946777,
0.034343115985393524,
0.019624637439846992,
0.008289513178169727,
0.007542923558503389,
0.022409534081816673,
0.058921314775943756,
-0.01382968109101057,
-0.02538404054939747,
-0.05138431489467621,
-0.005771255120635033,
0.027896374464035034,
-0.0002842298708856106,
-0.014931788668036461,
-0.08176931738853455,
0.03178337961435318,
0.01079592015594244,
-0.040623947978019714,
0.003993661142885685,
-0.025573652237653732,
-0.008538376539945602,
0.09030177444219589,
0.009059803560376167,
0.10513875633478165,
0.04697588086128235,
0.011927654966711998,
0.005996416788548231,
-0.036665838211774826,
-0.014967340975999832,
-0.06693233549594879,
0.02067934349179268,
-0.0221251193434,
0.011637315154075623,
-0.023618297651410103,
0.03372688218951225,
-0.028228191658854485,
-0.009018326178193092,
0.004156607203185558,
0.043705109506845474,
-0.003549262648448348,
0.00748959556221962,
-0.01250241044908762,
-0.028228191658854485,
0.049156397581100464,
-0.0018057391280308366,
0.03799310699105263,
0.05000964179635048,
-0.02957916259765625,
0.015796884894371033,
-0.02765936218202114,
-0.0008539857226423919,
-0.02588176727294922,
0.051526524126529694,
0.007501446176320314,
0.027848972007632256,
-0.03972329944372177,
-0.031807079911231995,
0.04818464443087578,
0.006417114287614822,
-0.02117706835269928,
0.00819470826536417,
0.06143364682793617,
-0.025312937796115875,
0.031024938449263573,
-0.036428824067115784,
0.02600027434527874,
0.022445086389780045,
0.0011895066127181053,
-0.011098111048340797,
-0.05944273993372917,
0.014742178842425346,
0.02363014779984951,
0.0043225158005952835,
0.029105138033628464,
-0.036215513944625854,
0.04538789764046669,
-0.011287721805274487,
-0.024151576682925224,
0.008656882680952549,
0.017704835161566734,
-0.018984703347086906,
-0.019494280219078064,
0.0202171690762043,
-0.057594042271375656,
0.027185335755348206,
0.030337603762745857,
0.043491799384355545,
-0.01592724211513996,
0.004601005464792252,
-0.014576270245015621,
-0.025929169729351997,
0.030835328623652458,
0.01090257614850998,
-0.023570895195007324,
0.027351245284080505,
-0.041714202612638474,
-0.0004318071878515184,
-0.0367843434214592,
-0.0440843291580677,
0.01119291689246893,
0.00367073155939579,
0.05062587559223175,
0.02126002311706543,
0.012680170126259327,
0.0367843434214592,
0.0013998552458360791,
-0.017195258289575577,
-0.016875291243195534,
-0.010813696309924126,
-0.010849248617887497,
0.039296675473451614,
0.022516189143061638,
-0.00519057409837842,
-0.013047539629042149,
-0.043871019035577774,
0.03465123102068901,
0.023985667154192924,
0.00014313335123006254,
0.04105056822299957,
-0.010944053530693054,
-0.021473335102200508,
-0.0003190410789102316,
0.03194928914308548,
0.00002967285763588734,
-0.013474161736667156,
0.009705662727355957,
-0.0006995573057793081,
0.013486012816429138,
0.02528923563659191,
0.02205401472747326,
0.05361223220825195,
0.03820641711354256,
0.005128358490765095,
0.024033069610595703,
-0.003969959914684296,
0.0030604242347180843,
-0.0214614849537611,
0.0053890724666416645,
0.028631113469600677,
-0.03370318189263344,
-0.04500867798924446,
-0.02682981826364994,
-0.05925313010811806,
-0.031190847977995872,
-0.007169628981500864,
-0.007673280313611031,
-0.01764558255672455,
-0.01553617138415575,
-0.015607275068759918,
0.0036973953247070312,
0.03356097266077995,
-0.01167286653071642,
-0.02200661227107048,
-0.05811547115445137,
-0.01617610454559326,
-0.04792393371462822,
0.02969766966998577,
-0.005406848154962063,
0.019375773146748543,
0.041619397699832916,
0.0011161809088662267,
-0.005415736231952906,
-0.026426896452903748,
0.01297643594443798,
-0.019944604486227036,
-0.03934407979249954,
0.01792999729514122,
0.00035811110865324736,
0.03303954750299454,
-0.01385338231921196,
0.016946395859122276,
0.019992006942629814,
0.028678515926003456,
-0.016235357150435448,
0.005723852664232254,
0.0012272804742679,
0.0198853500187397,
-0.017823342233896255,
0.01622350700199604,
-0.011400301940739155,
-0.003054498927667737,
-0.03386909142136574,
-0.013616369105875492,
-0.031167147681117058,
-0.012105414643883705,
-0.024435991421341896,
-0.03405870124697685,
-0.019150611013174057,
0.00400551175698638,
-0.012028385885059834,
-0.014730328693985939,
-0.008473197929561138,
0.0004358808510005474,
-0.012016534805297852,
-0.03690284863114357,
0.039083365350961685,
-0.012692020274698734,
0.00728220958262682,
0.0021908844355493784,
-0.04247264564037323,
0.04621744155883789,
0.012443157844245434,
-0.027683062478899956,
0.02649800106883049,
-0.002879702253267169,
0.008976849727332592,
-0.018581781536340714,
-0.020572686567902565,
-0.024412289261817932,
0.05399145185947418,
-0.012383904308080673,
0.022516189143061638,
-0.052853792905807495,
-0.014137797057628632,
-0.004772839602082968,
0.004944673739373684,
0.0275882575660944,
0.003054498927667737,
0.035338565707206726,
0.013083091005682945,
-0.018415873870253563,
0.019648337736725807,
0.016981948167085648,
-0.03303954750299454,
-0.0077266083098948,
-0.0008399131475016475,
0.011394376866519451,
-0.01098553091287613,
-0.029057735577225685,
-0.0452456921339035,
0.0017864819383248687,
0.04448724910616875,
0.0035107480362057686,
-0.011329198256134987,
-0.02421082928776741,
0.003401129739359021,
0.04389471933245659,
0.00984194502234459,
-0.012360203079879284,
0.002044233027845621,
0.007288135122507811,
0.02995838224887848,
-0.008603554219007492,
-0.023902712389826775,
0.006588947959244251,
-0.030361304059624672,
-0.01680418848991394,
0.009308666922152042,
-0.002848594216629863,
0.0214614849537611,
0.006529694888740778,
-0.0551765151321888,
-0.007483670487999916,
-0.015488767996430397,
-0.0057742176577448845,
0.018830645829439163,
0.009361994452774525,
-0.006494143046438694,
-0.024021219462156296,
0.03514895588159561,
-0.018202561885118484,
-0.04891938343644142,
0.03782719746232033,
0.0050335535779595375,
-0.0025715858209878206,
0.005140209104865789,
-0.026189884170889854,
0.00863318145275116,
-0.007797711994498968,
-0.017337465658783913,
0.02720903791487217,
0.007625877857208252,
-0.029508059844374657,
-0.014161498285830021,
0.022516189143061638,
-0.012372054159641266,
-0.02084525115787983,
-0.04223563149571419,
0.015500619076192379,
-0.014327406883239746,
0.00666597718372941,
-0.010641862638294697,
-0.009142758324742317,
0.018747691065073013,
0.062002476304769516,
0.06584207713603973,
0.002201253781095147,
0.02666390873491764,
-0.029721369966864586,
0.0035729638766497374,
0.00037810904905200005,
0.005258715245872736,
0.015287308022379875,
-0.002541959285736084,
0.02205401472747326,
-0.00671930518001318,
0.07636543363332748,
0.02162739261984825,
0.013426759280264378,
-0.0142089007422328,
-0.018107756972312927,
-0.004310665186494589,
-0.00364110479131341,
0.0066600521095097065,
-0.028275594115257263,
-0.003925519995391369,
0.0013968925923109055,
-0.010665563866496086,
-0.03453272581100464,
-0.09485241025686264,
0.015619125217199326,
0.007797711994498968,
0.010155986994504929,
-0.02233842946588993,
0.005291304551064968,
-0.010114509612321854,
-0.009036102332174778,
-0.030479811131954193,
-0.020940056070685387,
-0.013533415272831917,
0.026972025632858276,
0.0185580812394619,
0.006239354610443115,
-0.02479151077568531,
-0.0025464033242315054,
-0.00018516603449825197,
0.017787789925932884,
0.015512469224631786,
0.03372688218951225,
-0.02333388291299343,
0.00902425218373537,
-0.013545265421271324,
-0.022148819640278816,
-0.022445086389780045,
0.009960451163351536,
0.05512911453843117,
0.00400551175698638,
-0.01618795469403267,
-0.011139588430523872,
-0.02421082928776741,
-0.0025819551665335894,
0.01468292623758316,
-0.0038958934601396322,
0.02754085510969162,
0.002592324512079358,
0.015168801881372929,
0.007566624786704779,
0.008016948588192463,
-0.006091221701353788,
0.0007095562177710235,
0.04716549068689346,
0.044534653425216675,
-0.05228496342897415,
0.06152845174074173,
0.013651921413838863,
-0.007720682770013809,
0.0015257680788636208,
-0.031024938449263573,
-0.023559045046567917,
0.007519222330302,
-0.022942813113331795,
0.0285837110131979,
-0.020442329347133636,
-0.02649800106883049,
-0.010926277376711369,
-0.018878048285841942,
0.03920187056064606,
-0.0414297878742218,
-0.01635386422276497,
0.03266032412648201,
-0.017728537321090698,
0.021058563143014908,
0.03095383569598198,
0.00821840949356556,
-0.020537134259939194,
-0.02595287188887596,
-0.011601762846112251,
0.008354691788554192,
0.022788753733038902,
0.008413944393396378,
-0.0046365573070943356,
-0.05095769092440605,
-0.009539754129946232,
-0.01784704253077507,
-0.0376138873398304,
-0.018949151039123535,
-0.015702079981565475,
0.019032105803489685,
0.00687336316332221,
0.015429515391588211,
0.007797711994498968,
-0.00007318687858060002,
-0.0017124154837802052,
0.007175554055720568,
-0.015180652029812336,
0.019245417788624763,
-0.013841531239449978,
-0.011518809013068676,
0.013237149454653263,
-0.03680804371833801,
-0.011631389148533344,
0.027801569551229477,
-0.010665563866496086,
0.031972989439964294,
-0.008805015124380589,
0.020975608378648758,
0.005504616070538759,
0.005608309060335159,
0.01909135840833187,
-0.00006138253957033157,
-0.008556151762604713,
0.0012820896226912737,
0.006565246731042862,
0.02654540352523327,
-0.011323273181915283,
-0.046359650790691376,
-0.025763262063264847,
0.012028385885059834,
-0.009397546760737896,
0.00395218376070261,
-0.006991869304329157,
0.035717789083719254,
0.026972025632858276,
-0.09376215189695358,
-0.02233842946588993,
-0.02246878668665886,
0.0019523906521499157,
-0.037590187042951584,
0.001236909069120884,
-0.050815485417842865,
-0.012680170126259327,
-0.017586329951882362,
-0.01144177932292223,
0.012395755387842655,
-0.04614633694291115,
0.00006096591823734343,
-0.017610030248761177,
-0.0068970643915236,
0.016413116827607155,
-0.013675622642040253,
-0.024886315688490868,
0.015239905565977097,
0.0427570603787899,
0.003472233423963189,
0.0067252302542328835,
-0.022018464282155037,
0.037945706397295,
0.004192159045487642,
-0.005842358805239201,
-0.012786826118826866,
-0.00852652546018362,
-0.03865674138069153,
0.006855587475001812,
0.019565382972359657,
0.0008599110879004002,
-0.0013376394053921103,
0.013201597146689892,
-0.011506957933306694,
-0.04377621412277222,
0.013035688549280167,
-0.011512883007526398,
0.005842358805239201,
-0.0016724196029826999,
0.002264950890094042,
0.02770676463842392,
0.0070866746827960014,
0.008639106526970863,
0.0034100175835192204,
-0.007762160152196884,
-0.023938264697790146,
0.024033069610595703,
0.011258094571530819,
0.002758233342319727,
0.012609066441655159,
-0.027422349900007248,
-0.03161747008562088,
-0.006541545502841473,
-0.022812455892562866,
-0.011222543194890022,
-0.000010994232980010565,
0.016045747324824333,
0.01718340814113617,
0.00400551175698638,
-0.023191675543785095,
0.04832685366272926,
0.025644754990935326,
-0.009367920458316803,
0.004438059404492378,
-0.005448325537145138,
-0.04252004623413086,
0.03420090675354004,
-0.028820723295211792,
0.007169628981500864,
-0.01796554960310459,
0.000957678712438792,
-0.03519636020064354,
-0.001670938334427774,
-0.009065728634595871,
0.00364110479131341,
-0.015168801881372929,
-0.009859721176326275,
0.003922557458281517,
0.02354719489812851,
-0.010896651074290276,
-0.02874961867928505,
-0.020039409399032593,
0.023096870630979538,
-0.02595287188887596,
-0.018001101911067963,
0.0027552705723792315,
0.01768113486468792,
0.012656468898057938,
-0.005880873184651136,
-0.013189746998250484,
-0.02870221622288227,
-0.003125602612271905,
-0.004221785347908735,
0.007347388193011284,
-0.0013435647124424577,
-0.03394019231200218,
-0.007590326014906168,
-0.0076792058534920216,
-0.025407742708921432,
0.04313628003001213,
-0.03045610897243023,
-0.013284551911056042,
-0.0010761850280687213,
-0.014007439836859703,
0.0032885486725717783,
0.05228496342897415,
0.002690092194825411,
-0.006790408864617348,
-0.01643681898713112,
0.027730464935302734,
-0.0068970643915236,
0.015050294809043407,
0.011933580972254276,
0.006245280150324106,
0.010345596820116043,
0.03123825043439865,
-0.03699765354394913,
0.01297643594443798,
-0.0015072515234351158,
0.06498883664608002,
0.01605759933590889,
0.0015257680788636208,
-0.024933718144893646,
-0.021852554753422737,
0.0207148939371109,
0.035006750375032425,
-0.009687886573374271,
-0.00026478743529878557,
-0.000818433880340308,
0.011892103590071201,
0.006221578922122717,
0.006417114287614822,
-0.012034310959279537,
-0.0070866746827960014,
0.042828161269426346,
0.027351245284080505,
-0.002784897107630968,
0.0041536446660757065,
0.008822791278362274,
0.002420490374788642,
-0.00831913948059082,
-0.0009599007316865027,
-0.004639520309865475,
0.05674079805612564,
-0.006594873499125242,
-0.04422653838992119,
0.0427570603787899,
-0.007584400940686464,
0.03145156055688858,
-0.053185611963272095,
0.035054150968790054,
0.023487940430641174,
0.035551879554986954,
0.009616782888770103,
0.031972989439964294,
0.032589223235845566,
-0.03619181364774704,
-0.03597849979996681,
0.005291304551064968,
-0.03488824516534805,
0.03967589512467384,
-0.016282759606838226,
-0.017420420423150063,
0.006363786291331053,
-0.014457764104008675,
-0.026071377098560333,
-0.0029982083942741156,
-0.0048232050612568855,
0.007542923558503389,
0.0207148939371109,
-0.047449905425310135,
0.05413366109132767,
-0.0014665150083601475,
-0.035622984170913696,
-0.022705798968672752,
-0.002724162768572569,
0.02288355864584446,
0.005229088943451643,
0.03969959914684296,
-0.033797986805438995,
0.0028515569865703583,
0.015239905565977097,
-0.0074007161892950535,
0.02391456440091133,
-0.0024427103344351053,
-0.012289099395275116,
-0.011222543194890022,
0.03988920897245407,
-0.016164254397153854,
-0.01506214588880539,
-0.041334982961416245,
-0.009510127827525139,
0.04263855144381523,
0.03932037949562073,
-0.009788617491722107,
-0.03261292353272438,
0.022077716886997223,
-0.050815485417842865,
-0.036713238805532455,
-0.01651977375149727,
0.022018464282155037,
0.031972989439964294,
-0.019150611013174057,
-0.01382968109101057,
0.020774148404598236,
-0.014066693373024464,
-0.05176353454589844,
0.0005584607715718448,
0.05195314437150955,
0.0037003580946475267,
0.02637949399650097,
-0.04768691956996918,
0.015488767996430397,
0.02192365936934948,
-0.004052914213389158,
-0.01925726793706417,
-0.006743006408214569,
-0.038301222026348114,
-0.027256440371274948,
-0.021236322820186615,
-0.03356097266077995,
0.007643654011189938,
-0.0011909878812730312,
0.005270565859973431,
-0.010345596820116043,
0.020892653614282608,
0.025905469432473183,
0.0006321568507701159,
0.010209314525127411,
-0.025194430723786354,
0.025692157447338104,
0.005344632547348738,
-0.0007243695436045527,
-0.000016248319298028946,
-0.01796554960310459,
-0.004494349937886,
-0.034011296927928925,
0.01256166398525238,
-0.037376873195171356,
0.03166487440466881,
0.02429378405213356,
0.01410224474966526,
-0.012715721502900124,
-0.009830094873905182,
-0.01081962138414383,
0.0367843434214592,
-0.032091494649648666,
-0.029839877039194107,
0.010387074202299118,
-0.020027557387948036,
0.0024427103344351053,
0.02517073042690754,
0.034129802137613297,
0.03751908242702484,
-0.004177345894277096,
0.00496244989335537,
0.014137797057628632,
0.03149896487593651,
0.013237149454653263,
0.0032589221373200417,
0.0004621744155883789,
0.006825960706919432,
-0.01456441916525364,
0.0018575856229290366,
-0.012846078723669052,
-0.0057682921178638935,
-0.022314729169011116,
0.02391456440091133,
0.018202561885118484,
0.01553617138415575,
0.012929033488035202,
-0.003454457502812147,
-0.001235427800565958,
-0.012324650771915913,
-0.015749482437968254,
0.018404021859169006,
-0.006203802768141031,
0.020074959844350815,
-0.0002925623266492039,
0.004020324908196926,
-0.03540967032313347,
-0.01627090945839882,
-0.006529694888740778,
0.005380184389650822,
0.01152473408728838,
-0.03372688218951225,
-0.02424638159573078,
0.01789444498717785,
-0.035338565707206726,
-0.017290063202381134,
0.011655091308057308,
-0.015879839658737183,
0.004870607517659664,
-0.001993867801502347,
-0.01630646176636219,
-0.00687336316332221,
-0.0027552705723792315,
0.020809698849916458,
-0.012395755387842655,
0.014054842293262482,
0.026142481714487076,
-0.02391456440091133,
-0.003652955638244748,
0.005975678097456694,
0.011749896220862865,
-0.008722061291337013,
-0.042946670204401016,
0.043159980326890945,
-0.02595287188887596,
-0.05446547642350197,
0.03348986804485321,
0.005474989302456379,
-0.020987458527088165,
0.019032105803489685,
0.012253547087311745,
-0.007027421146631241,
0.03856193646788597,
0.006180101539939642,
0.012455007992684841,
-0.0037803498562425375,
0.006257130764424801,
0.008455421775579453,
-0.006748931482434273,
-0.010487804189324379,
-0.011429929174482822,
0.02001570723950863,
-0.00728220958262682,
-0.0009776767110452056,
-0.0059845661744475365,
0.03187818452715874,
-0.016863441094756126,
-0.0031818931456655264,
-0.0020323824137449265,
-0.006197877693921328,
0.009267189539968967,
0.0023612373042851686,
0.019292820245027542,
-0.0015272494638338685,
-0.0002999689895659685,
-0.006428964901715517,
-0.0073947906494140625,
0.0207148939371109,
0.03320545330643654,
0.007098525296896696,
-0.0016916769091039896,
-0.01451701670885086,
-0.0214614849537611,
-0.017290063202381134,
-0.005869022570550442,
0.0588265098631382,
-0.024270081892609596,
-0.03045610897243023,
0.05280638858675957,
0.017171557992696762,
0.005679412744939327,
0.023487940430641174,
0.005024665500968695,
-0.003350764513015747,
0.0012213551672175527,
-0.01918616332113743,
0.02749345265328884,
0.0402684286236763,
-0.00992489978671074,
0.012857929803431034,
0.021485185250639915,
-0.017574477940797806,
-0.013237149454653263,
-0.001193950534798205,
0.013486012816429138,
0.030764225870370865,
0.01294088363647461,
-0.03524376079440117,
-0.0192217156291008,
-0.0018768429290503263,
0.017420420423150063,
0.015583573840558529,
0.013841531239449978,
-0.0029967271257191896,
0.039130765944719315,
0.013912634924054146,
0.010712966322898865,
-0.007590326014906168,
-0.010452251881361008,
0.012383904308080673,
-0.052142754197120667,
-0.026450596749782562,
-0.03019539639353752,
0.027896374464035034,
0.01867658644914627,
0.010375223122537136,
-0.017444122582674026,
0.01291718240827322,
-0.005362408235669136,
-0.03299214318394661,
-0.03382168710231781,
0.0014250377425923944,
0.008828716352581978,
0.0009324961574748158,
-0.006766707636415958,
-0.04202232137322426,
-0.012229845859110355,
0.010280418209731579,
-0.014007439836859703,
0.018937300890684128,
0.010683339089155197,
0.023061318323016167,
0.02371310256421566,
0.005489802453666925,
-0.007732533384114504,
-0.020146064460277557,
-0.020833401009440422,
-0.06769077479839325,
0.01567837782204151,
-0.017918147146701813,
0.003602590411901474,
0.0054186987690627575,
-0.012727572582662106,
-0.019624637439846992,
-0.006760782096534967,
0.008976849727332592,
-0.004337329417467117,
-0.021876255050301552,
-0.010422625578939915,
-0.007566624786704779,
0.0025804738979786634,
0.017787789925932884,
0.013284551911056042,
-0.032186299562454224,
0.03268402814865112,
0.011104037053883076,
0.023357585072517395,
0.009581231512129307,
0.003978847526013851,
-0.013723025098443031,
-0.013308253139257431,
-0.014303705655038357,
0.033513572067022324,
-0.03815901651978493,
0.012395755387842655,
-0.017147855833172798,
-0.01333195436745882,
0.03730577230453491,
0.005824582651257515,
0.005943089257925749,
-0.0013761540176346898,
-0.016377564519643784,
-0.014280004426836967,
0.018961001187562943,
-0.0026752788107842207,
0.028133386746048927,
0.04204602167010307,
-0.0275882575660944,
-0.0037122087087482214,
-0.008200633339583874,
-0.0013028281973674893,
-0.020454181358218193,
-0.03510155528783798,
0.00834284070879221,
0.04256745055317879,
-0.04014991968870163,
-0.007211105898022652,
-0.0011509921168908477,
0.006547471042722464,
-0.0004047729598823935,
-0.000306820118566975,
-0.006737080868333578,
-0.010055256076157093,
-0.007145927753299475,
0.001217651879414916,
0.00495948689058423,
0.013960037380456924,
0.010375223122537136,
0.025858066976070404,
0.033632077276706696,
-0.04996224120259285,
0.017064901068806648,
0.009883422404527664,
-0.001062853028997779,
-0.009563455358147621,
-0.019826097413897514,
0.0048943087458610535,
0.0021568138618022203,
-0.0028426689095795155,
0.0389411561191082,
0.024198979139328003,
0.006186027079820633,
-0.026403194293379784,
0.03192558512091637,
0.02308502048254013,
-0.011714343912899494,
-0.008431720547378063,
-0.01809590682387352,
0.018546229228377342,
-0.00971158780157566,
0.013035688549280167,
-0.01250241044908762,
-0.024910015985369682,
-0.005163910333067179,
-0.008490974083542824,
-0.004912084434181452,
-0.004621744155883789,
-0.005057254806160927,
-0.010843322612345219,
0.013320104219019413,
-0.0053475950844585896,
-0.028465203940868378,
-0.05901611968874931,
0.03261292353272438,
0.0215444378554821,
-0.0282518919557333,
-0.02126002311706543,
-0.01067148894071579,
0.006434889975935221,
0.047402504831552505,
-0.026071377098560333,
-0.01913876086473465,
0.011323273181915283,
0.027351245284080505,
-0.0014894756022840738,
0.021058563143014908,
0.03123825043439865,
0.02371310256421566,
-0.028394101187586784,
-0.01061223540455103,
-0.021283725276589394,
-0.0183921717107296,
0.060959622263908386,
-0.007999172434210777,
0.017657432705163956,
0.01056483294814825,
-0.03339506313204765,
0.00894129741936922,
0.012217995710670948,
-0.01247870922088623,
0.03161747008562088,
-0.011465480551123619,
-0.006985944230109453,
-0.0357888899743557,
-0.01052335649728775,
-0.026735013350844383,
0.03431941196322441,
0.026260986924171448,
-0.013592667877674103,
0.02013421431183815,
0.014671075157821178,
0.02462560124695301,
-0.011909879744052887,
-0.015311009250581264,
0.0016783449100330472,
0.043112579733133316,
0.02092820592224598,
-0.023274630308151245,
0.000931014830712229,
-0.01547691784799099,
-0.004429171327501535,
-0.015050294809043407,
0.0046839602291584015,
-0.026237286627292633,
-0.015204353258013725,
-0.008123604580760002,
0.006784483324736357,
-0.0033181754406541586,
-0.0045387898571789265,
-0.0012732016621157527,
-0.0011495107319206,
-0.01788259483873844,
-0.009468650445342064,
-0.029484357684850693,
0.0002805265539791435,
-0.009474575519561768,
-0.033015843480825424,
-0.010446326807141304,
-0.028986630961298943,
-0.005214275326579809,
0.004313627723604441,
-0.011465480551123619,
0.019814247265458107,
-0.025218132883310318,
-0.009753065183758736,
0.00011785818060161546,
-0.020051259547472,
-0.015962792560458183,
0.003412980353459716,
-0.031475264579057693,
-0.03685544803738594,
-0.046738870441913605,
-0.011435854248702526,
0.0022901336196810007,
0.00004369918315205723,
-0.05072068050503731,
0.00487949512898922,
0.011809148825705051,
-0.03154636546969414,
0.01335565559566021,
0.04346809536218643,
-0.00226198835298419,
0.02969766966998577,
-0.03493564575910568,
0.007933993823826313,
-0.03389279171824455,
0.01668568141758442,
-0.023890862241387367,
-0.009557530283927917,
-0.002331610769033432,
-0.006144549697637558,
-0.013047539629042149,
-0.01429185550659895,
-0.007774010766297579,
0.007643654011189938,
-0.011341049335896969,
-0.0009428654448129237,
-0.007536998484283686,
0.01875954121351242,
-0.003175967838615179,
0.010227090679109097,
-0.020774148404598236,
-0.005267603322863579,
0.024139724671840668,
0.013320104219019413,
0.02416342683136463,
0.044913873076438904,
-0.03358467295765877,
-0.0026619469281286,
0.019316520541906357,
0.026616506278514862,
-0.006328234449028969,
-0.01067148894071579,
0.024139724671840668,
-0.020311973989009857,
-0.007809562608599663,
0.02250433899462223,
0.022373981773853302,
-0.014505166560411453,
-0.015358411706984043,
-0.01867658644914627,
0.005412773694843054,
-0.008686508983373642,
-0.030669420957565308,
0.006766707636415958,
-0.029057735577225685,
0.015168801881372929,
0.010155986994504929,
0.01796554960310459,
-0.04427393898367882,
0.026071377098560333,
-0.012016534805297852,
-0.005874948110431433,
0.019150611013174057,
0.007448118645697832,
-0.012300949543714523,
0.014919938519597054,
0.01788259483873844,
0.006108997855335474,
0.036547333002090454,
0.018238114193081856,
-0.02409232221543789,
0.015346560627222061,
-0.015311009250581264,
-0.0031374532263725996,
0.0203001219779253,
-0.020240869373083115,
0.011773597449064255,
0.026355791836977005,
0.02200661227107048,
-0.0035107480362057686,
0.016839738935232162,
-0.002740457421168685,
-0.04934600740671158,
0.009652335196733475,
-0.03161747008562088,
-0.00038588602910749614,
-0.020406778901815414,
-0.006630425341427326,
0.10106214135885239,
-0.015417664311826229,
0.039628494530916214,
0.028607411310076714,
-0.002334573306143284,
-0.010215239599347115,
0.02001570723950863,
0.021117815747857094,
0.013841531239449978,
-0.050436265766620636,
0.03204409405589104,
0.0290814358741045,
0.031759679317474365,
0.0031107894610613585,
0.033513572067022324,
-0.027611959725618362,
-0.0069681680761277676,
0.045861922204494476,
-0.004378806333988905,
-0.021390380337834358,
-0.007602176629006863,
0.020205317065119743,
-0.035385970026254654,
0.020074959844350815,
-0.018866196274757385,
-0.039794404059648514,
0.00007286283653229475,
-0.013059389777481556,
-0.011258094571530819,
0.000020854324247920886,
0.0012465377803891897,
0.025478845462203026,
0.015796884894371033,
-0.007181479595601559,
0.00796362105756998,
0.004180308431386948,
-0.015358411706984043,
-0.02633209154009819,
0.03206779435276985,
0.0009176828898489475,
-0.0057386658154428005,
-0.0017168595222756267,
-0.01173212006688118,
0.0188069436699152,
0.006505993660539389,
-0.023736804723739624,
-0.009290890768170357,
-0.005655711516737938,
0.012597215361893177,
-0.004974300507456064,
-0.006837811321020126,
-0.01892545074224472,
0.02300206571817398,
-0.028062282130122185,
-0.02870221622288227,
-0.04256745055317879,
0.01789444498717785,
0.003507785266265273,
-0.021556289866566658,
-0.014671075157821178,
-0.01743227057158947,
0.013367506675422192,
-0.002263469621539116,
-0.0009984152857214212,
0.0014716996811330318
] | 2024-07-05 | 25 | 38968138 | [
"CD8+ CAR T cells",
"diverse immune cells",
"IL15 receptor agonism",
"IL15",
"high response rates",
"CAR19",
"-",
"absolute lymphocyte counts",
"many patients",
"significant increases",
"cerebrospinal fluid CAR-T cells",
"high rates",
"lymphocyte trafficking",
"transient fever",
"NKTR-255",
"B-cell malignancies",
"historical controls",
"a novel recombinant polymer-conjugated IL15 receptor agonist",
"durable responses",
"correlative analyses",
"relapsed/refractory B-cell acute lymphoblastic leukemia",
"antitumor immunity",
"favorable efficacy",
"chemokines",
"Cytokine profiling",
"a novel autologous bispecific CAR",
"measurable residual disease-negative remission",
"first",
"10-fold increases",
"CAR"
] | [] | 0 | 10.1182/blood.2024024952 | [
"Srinagesh",
"Jackson",
"Shiraz",
"Jeyakumar",
"Hamilton",
"Egeler",
"Mavroukakis",
"Kuo",
"Cancilla",
"Sahaf",
"Agarwal",
"Kanegai",
"Kramer",
"Arai",
"Bharadwaj",
"Dahiya",
"Hosoya",
"Johnston",
"Kennedy",
"Liedtke",
"Lowsky",
"Mikkilineni",
"Negrin",
"Rezvani",
"Sidana",
"Shizuru",
"Smith",
"Weng",
"Feldman",
"Frank",
"Lee",
"Tagliaferri",
"Marcondes",
"Miklos",
"Mackall",
"Muffly"
] | [
"Division of Hematology, Stanford University, Stanford, CA.",
"Division of Hematology/Oncology, UT Southwestern, Dallas, TX.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Hematology, Stanford University, Stanford, CA.",
"Division of Hematology, Stanford University, Stanford, CA.",
"Center for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Center for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Center for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Center for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Center for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.\nCenter for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Hematology, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.",
"Center for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.\nCenter for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Nektar Therapeutics, San Francisco, CA.",
"Nektar Therapeutics, San Francisco, CA.",
"Nektar Therapeutics, San Francisco, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.\nCenter for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Center for Cancer Cell Therapy, Stanford University, Stanford, CA.",
"Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University, Stanford, CA.\nCenter for Cancer Cell Therapy, Stanford University, Stanford, CA."
] | [
"38968138",
"33764809",
"36108252",
"30135176",
"37647647",
"30581986",
"34312556",
"35476848",
"25359408",
"12070280",
"26627006",
"30890531",
"25403209",
"29895668",
"28291388",
"37564658",
"37910044",
"31142503",
"34001523",
"36332004",
"30592986",
"36906275",
"29385376",
"34767461",
"23469246"
] | [] | 7.367435 | 5.514471 |
38966037 | 759 | Rejection resistant CD30.CAR-modified Epstein-Barr virus-specific T cells as an off-the-shelf platform for CD30 | Off-the-shelf (OTS) adoptive T cell therapies have many benefits such as immediate availability, improved access and reduced cost, but face the major challenges of graft-vs-host disease (GVHD) and graft rejection, mediated by alloreactive T cells present in the graft and host, respectively. We have developed a platform for OTS T cell therapies by using Epstein-Bar virus (EBV)-specific T cells (EBVSTs) expressing a chimeric antigen receptor (CAR) targeting CD30. Allogeneic EBVSTs have not caused GVHD in several clinical trials, while the CD30.CAR, that is effective for the treatment of lymphoma, can also target alloreactive T cells that upregulate CD30 on activation. Although EBVSTs express high levels of CD30, they were protected from fratricide | [
0.009207677096128464,
-0.022766560316085815,
0.06533943116664886,
0.04296519607305527,
-0.047791942954063416,
0.003299070755019784,
-0.0033763463143259287,
0.024585507810115814,
0.0015247056726366282,
-0.004440370947122574,
0.014504022896289825,
-0.019758759066462517,
-0.0279618538916111,
-0.0055697825737297535,
0.008553806692361832,
-0.03010179102420807,
0.03288371115922928,
-0.01883145235478878,
-0.016489408910274506,
0.018688790500164032,
0.051120735704898834,
0.018962226808071136,
0.0034922596532851458,
0.0078286062926054,
-0.0267730001360178,
-0.021482598036527634,
0.039517518132925034,
-0.0053201233968138695,
-0.015562103129923344,
-0.06110711395740509,
0.007026128936558962,
-0.0392797477543354,
-0.005052630789577961,
-0.02995912916958332,
0.0073292870074510574,
0.04717373847961426,
0.04184767231345177,
0.0070320735685527325,
0.0033377085346728563,
0.02343231998383999,
0.049694109708070755,
0.02924581617116928,
0.03687826171517372,
0.06776469945907593,
-0.04574711620807648,
0.003001857316121459,
0.007632445078343153,
-0.03338303044438362,
-0.0033079872373491526,
-0.028461173176765442,
0.01613275334239006,
0.010117150843143463,
-0.017606932669878006,
0.012209533713757992,
-0.0156572125852108,
0.020151080563664436,
-0.028270956128835678,
0.03538030385971069,
-0.019580431282520294,
0.029911575838923454,
-0.0013226004084572196,
-0.035475414246320724,
0.007483838126063347,
-0.015074673108756542,
-0.03442922234535217,
0.0001900309434859082,
-0.05554327368736267,
-0.02432396076619625,
-0.022124579176306725,
0.0022023527417331934,
-0.012946623377501965,
-0.00822687242180109,
0.03597473353147507,
0.007186624687165022,
0.06048890948295593,
0.018130028620362282,
-0.01474179420620203,
0.04577089101076126,
0.019164331257343292,
-0.034357890486717224,
0.04848147928714752,
0.022279130294919014,
-0.008684581145644188,
-0.013243837282061577,
0.017214611172676086,
0.014111701399087906,
0.005676779430359602,
-0.03297881782054901,
-0.05682723596692085,
0.006384147796779871,
-0.03202773630619049,
-0.001786253647878766,
-0.031980182975530624,
0.01382637582719326,
-0.005129906348884106,
0.01207876019179821,
-0.029697582125663757,
-0.05877695977687836,
0.028698943555355072,
0.015217335894703865,
0.013279503211379051,
-0.02056718058884144,
-0.02941225655376911,
-0.01188259944319725,
0.05492506921291351,
-0.0145396888256073,
-0.010866128839552402,
0.0014912692131474614,
0.03773423656821251,
0.010063651949167252,
0.0175474900752306,
0.0016183279221877456,
0.00942167080938816,
0.012019317597150803,
-0.00556383840739727,
-0.06015602871775627,
-0.018641235306859016,
-0.03409634158015251,
0.006865633651614189,
-0.00917201116681099,
-0.027034547179937363,
0.021387489512562752,
0.029697582125663757,
-0.01228086557239294,
-0.02734364941716194,
-0.0022915166337043047,
0.04638909548521042,
-0.03176618739962578,
-0.05259491503238678,
-0.10119528323411942,
0.06847801059484482,
-0.005560866091400385,
0.02917448617517948,
-0.0009235912002623081,
-0.04988432675600052,
0.008637026883661747,
-0.030767550691962242,
-0.01709572598338127,
-0.006936965044587851,
0.02201758325099945,
0.005968048702925444,
-0.051691386848688126,
-0.00025708976318128407,
0.004262042697519064,
-0.03566563129425049,
-0.0408252589404583,
-0.002618451602756977,
0.026677891612052917,
-0.03454810753464699,
0.051453616470098495,
-0.03887553513050079,
0.005094240885227919,
0.046698197722435,
0.01263752207159996,
-0.003215851029381156,
-0.03725869581103325,
0.0015960369491949677,
0.04817237704992294,
0.01072941068559885,
-0.043583400547504425,
-0.005596532020717859,
-0.0032069345470517874,
0.01715516857802868,
-0.017416715621948242,
0.009784271009266376,
0.019734982401132584,
0.01834402233362198,
0.04339318349957466,
-0.030006684362888336,
0.0058996896259486675,
0.025703031569719315,
-0.02487083338201046,
-0.05516284331679344,
0.023146994411945343,
-0.056066371500492096,
-0.012185757048428059,
-0.009112568572163582,
0.005754054989665747,
0.0022840863093733788,
-0.06999974697828293,
-0.0035754793789237738,
0.036426495760679245,
0.04420160502195358,
-0.014349471777677536,
-0.030553556978702545,
0.004591949749737978,
-0.0039083585143089294,
-0.004083714447915554,
-0.06909621506929398,
-0.018415354192256927,
0.009142289869487286,
-0.022980554029345512,
0.040492378175258636,
0.004526562988758087,
0.0370447002351284,
-0.02938847988843918,
0.016251638531684875,
0.03528519719839096,
-0.027034547179937363,
-0.05425931140780449,
0.02144693210721016,
-0.03416767343878746,
-0.02884160540997982,
-0.00544198090210557,
-0.028175847604870796,
-0.03630761057138443,
0.011008791625499725,
0.05159628018736839,
0.021482598036527634,
0.014753682538866997,
0.04562823101878166,
-0.012447305023670197,
-0.018320245668292046,
0.030054237693548203,
-0.015776097774505615,
-0.02249312400817871,
-0.030387116596102715,
0.03963640332221985,
0.031266868114471436,
0.02003219537436962,
-0.0030419810209423304,
-0.006003714632242918,
-0.02534637413918972,
0.014408914372324944,
-0.00504371477290988,
0.006610030308365822,
-0.007876159623265266,
-0.020151080563664436,
-0.021744145080447197,
-0.04313163459300995,
-0.031052876263856888,
-0.005956160370260477,
-0.01993708685040474,
-0.06790736317634583,
-0.042632315307855606,
0.032859932631254196,
0.03511875867843628,
-0.0009295354830101132,
0.028175847604870796,
-0.0267730001360178,
0.03735380247235298,
0.010117150843143463,
0.035071201622486115,
-0.0168460663408041,
-0.04607999324798584,
-0.0015247056726366282,
-0.007210401352494955,
-0.010580803267657757,
-0.0047286683693528175,
0.03121931478381157,
-0.03440544381737709,
0.018451020121574402,
-0.012185757048428059,
-0.023372875526547432,
0.02114971913397312,
0.013564827851951122,
0.03335925191640854,
-0.03447677567601204,
0.006354426499456167,
-0.01930699497461319,
0.008363590575754642,
-0.0017060060054063797,
-0.017511824145913124,
0.00961188692599535,
-0.04474847763776779,
0.034120120108127594,
0.016953062266111374,
0.011508109979331493,
0.04094414412975311,
0.024823278188705444,
0.04505757987499237,
0.006437646225094795,
0.05435442179441452,
-0.03839999437332153,
-0.03623627871274948,
-0.04034971818327904,
-0.0290793776512146,
0.018082475289702415,
-0.021280493587255478,
0.039779067039489746,
-0.018950337544083595,
0.008595417253673077,
-0.0291507076472044,
-0.005474674049764872,
-0.01493201032280922,
-0.0024282350204885006,
-0.005932383239269257,
-0.009201732464134693,
0.013885818421840668,
-0.022219687700271606,
-0.007721608970314264,
0.020448295399546623,
-0.030648665502667427,
-0.017773373052477837,
0.02955491840839386,
0.002940928330644965,
0.00014758511679247022,
0.0009889781940728426,
-0.006289039272814989,
-0.010943404398858547,
-0.00042315784958191216,
0.02065039984881878,
0.003902414347976446,
0.005507367663085461,
-0.003024148289114237,
0.035618074238300323,
0.0122333113104105,
0.03806711733341217,
0.018772009760141373,
0.03685448318719864,
0.005953188054263592,
-0.036426495760679245,
0.01442080270498991,
0.03918463736772537,
0.003676532069221139,
0.019021669402718544,
-0.00669325003400445,
-0.050169654190540314,
-0.018534239381551743,
-0.05673212930560112,
-0.023551205173134804,
-0.031671080738306046,
-0.038019560277462006,
0.021720368415117264,
0.007882104255259037,
-0.03797200694680214,
0.024751948192715645,
-0.01553832646459341,
0.02755764313042164,
-0.0064911446534097195,
0.012780183926224709,
-0.05178649351000786,
0.05140606313943863,
0.006925076711922884,
0.018558016046881676,
0.004553311970084906,
-0.0335494689643383,
-0.016953062266111374,
0.04988432675600052,
0.0037983895745128393,
-0.012744518928229809,
0.044296711683273315,
-0.0370447002351284,
0.01116928644478321,
-0.005825386382639408,
0.009100680239498615,
-0.024466622620821,
0.016786623746156693,
-0.007228234317153692,
0.0032485444098711014,
0.01843913085758686,
0.0037894733250141144,
0.0035011761356145144,
0.0009154178551398218,
0.01867690123617649,
-0.020531514659523964,
0.0043185134418308735,
-0.027367426082491875,
0.011151453480124474,
-0.008987738750874996,
0.056209031492471695,
0.008280370384454727,
-0.03136197850108147,
0.027628974989056587,
0.05896717682480812,
0.04776816815137863,
-0.03121931478381157,
0.029103154316544533,
-0.06405547261238098,
-0.03908953070640564,
-0.021827366203069687,
0.007584890816360712,
-0.043654732406139374,
0.009338450618088245,
-0.025393929332494736,
0.026654114946722984,
0.030933989211916924,
0.010343032889068127,
0.01914055459201336,
0.03036333993077278,
0.037853121757507324,
-0.012209533713757992,
-0.04141968488693237,
0.006104766856878996,
-0.02169659174978733,
0.03623627871274948,
0.006681361235678196,
0.0030910212080925703,
-0.07180680334568024,
0.021981917321681976,
-0.031171761453151703,
0.011995540000498295,
-0.024014858528971672,
0.014206808991730213,
-0.004690030589699745,
0.03164730221033096,
-0.03036333993077278,
0.09862735867500305,
0.032931264489889145,
0.02860383503139019,
-0.023337211459875107,
-0.020840616896748543,
-0.028580058366060257,
-0.04420160502195358,
-0.0027923216111958027,
-0.008434921503067017,
-0.008940184488892555,
0.030529780313372612,
0.02065039984881878,
-0.0654345452785492,
-0.018498573452234268,
-0.003703281283378601,
0.0232777688652277,
0.006764581426978111,
0.0314570851624012,
0.008298203349113464,
-0.06381770223379135,
0.05126339942216873,
0.005266624502837658,
0.03328792005777359,
0.046507980674505234,
0.0006895355181768537,
-0.005831330548971891,
-0.05896717682480812,
0.011769657954573631,
-0.0465555377304554,
0.012530525214970112,
0.0051091015338897705,
-0.0061939312145113945,
-0.05421175807714462,
-0.01993708685040474,
0.002239504363387823,
-0.0004216717788949609,
-0.05463974550366402,
-0.011591330170631409,
0.021672815084457397,
-0.020614733919501305,
0.03305014967918396,
0.018391577526926994,
0.042632315307855606,
-0.03295504301786423,
0.00023999996483325958,
-0.0535460002720356,
-0.031124206259846687,
0.0000769968974054791,
-0.024050522595643997,
0.004267986863851547,
-0.004514674190431833,
-0.046698197722435,
-0.007049906067550182,
0.018486684188246727,
-0.0371873639523983,
-0.0370447002351284,
-0.0005728791584260762,
-0.036046065390110016,
0.0072876769118011,
0.020365074276924133,
-0.04679330810904503,
0.0113238375633955,
0.030315786600112915,
0.007180680055171251,
-0.03003046102821827,
-0.002811640501022339,
-0.016168419271707535,
-0.010360865853726864,
0.028080739080905914,
0.039374854415655136,
-0.023420430719852448,
0.03338303044438362,
-0.00653869891539216,
0.01669151522219181,
-0.008131763897836208,
-0.003952940460294485,
0.02843739651143551,
-0.009796159341931343,
0.021589593961834908,
0.04172878712415695,
-0.00744817266240716,
0.02265956439077854,
-0.024775724858045578,
0.02510860376060009,
0.004930773284286261,
-0.010455974377691746,
-0.03390612453222275,
0.03407256677746773,
0.0338347963988781,
0.024585507810115814,
-0.012399750761687756,
-0.040254607796669006,
0.021387489512562752,
0.010628357529640198,
0.005427120253443718,
0.00976643804460764,
-0.010057707317173481,
-0.00149052613414824,
-0.021007055416703224,
-0.0029914546757936478,
-0.010432196781039238,
-0.01518166996538639,
0.028865383937954903,
0.015241112560033798,
-0.007703776005655527,
-0.04094414412975311,
0.033882349729537964,
0.0957741066813469,
0.05492506921291351,
0.0072341784834861755,
0.049075908958911896,
0.022386128082871437,
0.01979442499577999,
-0.040872812271118164,
-0.00530526228249073,
0.013766933232545853,
-0.01772581785917282,
-0.022433681413531303,
-0.026416342705488205,
-0.06895355135202408,
0.018653124570846558,
-0.016941174864768982,
-0.012685075402259827,
-0.0394224114716053,
0.012506747618317604,
-0.01859368197619915,
-0.02113782986998558,
0.02517993561923504,
-0.011900432407855988,
-0.019830090925097466,
-0.02900804579257965,
-0.062105752527713776,
-0.015359997749328613,
0.026249904185533524,
-0.027510089799761772,
0.02456173114478588,
-0.006205819547176361,
-0.0013716407120227814,
-0.01302984356880188,
-0.018855229020118713,
0.03362080082297325,
-0.0238365288823843,
-0.03573696315288544,
0.0025946747045964003,
0.003985634073615074,
0.03521386533975601,
0.011555664241313934,
0.0009414240485057235,
0.00074526306707412,
0.020555291324853897,
-0.012060927227139473,
-0.012001484632492065,
0.0056530022993683815,
0.005557894241064787,
-0.02239801548421383,
0.011864766478538513,
-0.013517273589968681,
-0.001985386712476611,
-0.05007454380393028,
-0.03378723934292793,
-0.022754672914743423,
-0.0057332501746714115,
0.001344148418866098,
-0.023503649979829788,
-0.017285943031311035,
0.024989718571305275,
-0.02049584873020649,
0.00882129929959774,
-0.0012676159385591745,
-0.018724456429481506,
-0.0013382041361182928,
-0.030957767739892006,
0.034381669014692307,
-0.03036333993077278,
0.005852135363966227,
0.01701250486075878,
0.02955491840839386,
0.026345012709498405,
0.0012319503584876657,
0.011216840706765652,
-0.010057707317173481,
-0.032931264489889145,
-0.003429844742640853,
-0.03121931478381157,
-0.03098154440522194,
-0.02986402064561844,
0.0440351665019989,
-0.0054063149727880955,
0.0373300276696682,
-0.05345088988542557,
-0.003944024443626404,
-0.0133865000680089,
0.0004944890970364213,
0.03949373960494995,
0.005079380236566067,
0.060346245765686035,
0.0032960986718535423,
-0.005219070706516504,
0.010996902361512184,
0.0032604329753667116,
-0.008321980014443398,
-0.0232777688652277,
-0.0324319452047348,
-0.007400618400424719,
-0.016881732270121574,
-0.005777832120656967,
-0.033501915633678436,
-0.006580309011042118,
0.010824519209563732,
-0.033169034868478775,
0.010140927508473396,
-0.00027325074188411236,
0.024442845955491066,
0.0715690329670906,
0.01116928644478321,
-0.010693744756281376,
0.004636532161384821,
0.0077751073986291885,
0.017452381551265717,
-0.027082102373242378,
-0.010497584007680416,
-0.0072341784834861755,
-0.013814487494528294,
-0.0017297830199822783,
0.002602105028927326,
-0.01172210369259119,
0.009290896356105804,
-0.049694109708070755,
-0.0072876769118011,
0.010271701961755753,
0.007804828695952892,
0.03963640332221985,
-0.0036824762355536222,
-0.013410276733338833,
-0.038328662514686584,
0.007192568853497505,
0.03744891285896301,
0.012696964666247368,
-0.037234917283058167,
0.039779067039489746,
-0.010354921221733093,
0.014111701399087906,
-0.003358513582497835,
-0.04092036560177803,
0.016667738556861877,
-0.0012899069115519524,
-0.008583527989685535,
0.040397271513938904,
-0.008928296156227589,
-0.05849163234233856,
0.006740804295986891,
-0.005447925068438053,
-0.008755912072956562,
-0.020460182800889015,
-0.0036676155868917704,
0.0454380139708519,
-0.0007950463332235813,
-0.007763219065964222,
-0.00365572702139616,
-0.011692382395267487,
0.0005134364473633468,
0.03963640332221985,
0.06824024021625519,
-0.005388482473790646,
-0.008654859848320484,
0.003985634073615074,
-0.015847427770495415,
-0.00019969037384726107,
-0.002666005864739418,
0.014147366397082806,
-0.010265757329761982,
0.000783157825935632,
-0.03787690028548241,
0.07404185086488724,
0.011989596299827099,
0.00866674818098545,
-0.05059764161705971,
0.004829720593988895,
-0.013802599161863327,
0.00806043203920126,
-0.039446186274290085,
-0.030957767739892006,
0.010444085113704205,
-0.004267986863851547,
0.013969038613140583,
-0.03464321419596672,
-0.04988432675600052,
-0.007477893959730864,
0.006615974474698305,
0.019342660903930664,
-0.019723093137145042,
0.004303652793169022,
-0.04092036560177803,
0.016750957816839218,
-0.009920989163219929,
-0.007769163232296705,
-0.015062784776091576,
0.025393929332494736,
0.010854240506887436,
-0.006300928071141243,
-0.007834549993276596,
-0.04363095387816429,
-0.014682350680232048,
0.03987417370080948,
0.009094735607504845,
0.026725444942712784,
-0.027510089799761772,
-0.012506747618317604,
-0.014634797349572182,
0.0018590709660202265,
-0.0007749844226054847,
-0.022754672914743423,
0.03880420699715614,
-0.029745135456323624,
0.0030315786134451628,
-0.018379688262939453,
-0.04693596810102463,
-0.014718016609549522,
0.007180680055171251,
-0.006419813260436058,
0.01890278421342373,
0.01994897611439228,
-0.0009079875308088958,
-0.023408541455864906,
0.03554674610495567,
-0.01715516857802868,
-0.015395663678646088,
0.02010352723300457,
0.015359997749328613,
-0.011187119409441948,
0.05872940272092819,
-0.025964578613638878,
-0.0044017331674695015,
0.010503527708351612,
-0.03183751925826073,
-0.005792692769318819,
-0.004782166797667742,
-0.00893424078822136,
0.035713184624910355,
-0.00942167080938816,
-0.04672197625041008,
-0.028746498748660088,
-0.011228729039430618,
0.03107665292918682,
-0.0035992565099149942,
-0.037948232144117355,
0.009623776189982891,
-0.003602228593081236,
-0.007525447756052017,
0.0006813621730543673,
0.01072346605360508,
-0.008755912072956562,
-0.02049584873020649,
-0.007210401352494955,
0.008571639657020569,
-0.019283218309283257,
-0.03335925191640854,
-0.019366437569260597,
-0.031813740730285645,
0.020543403923511505,
-0.01612086407840252,
-0.04950389638543129,
-0.018320245668292046,
-0.00790588092058897,
-0.019770648330450058,
-0.016739068552851677,
0.007216345984488726,
-0.017381049692630768,
0.008839132264256477,
-0.0011011763708665967,
0.0011041484540328383,
-0.010010153986513615,
0.02303999662399292,
-0.004428482614457607,
-0.0033704021479934454,
0.015550214797258377,
-0.03148086369037628,
-0.03580829128623009,
0.03756779804825783,
-0.017381049692630768,
-0.0357845164835453,
-0.008749968372285366,
0.024514175951480865,
-0.031171761453151703,
0.004663281142711639,
-0.004217460751533508,
0.00921956542879343,
-0.001532135996967554,
0.01493201032280922,
-0.008803466334939003,
0.054306864738464355,
-0.0196398738771677,
-0.03820977732539177,
-0.007733497302979231,
0.027462534606456757,
-0.033169034868478775,
0.06728915870189667,
-0.0015068728243932128,
0.009356283582746983,
0.010604580864310265,
-0.09658252447843552,
-0.00014999997802078724,
0.016239751130342484,
0.014563465490937233,
-0.03966018185019493,
0.0011026624124497175,
-0.02693943865597248,
-0.02938847988843918,
0.03274104744195938,
0.009053125977516174,
-0.00009678017522674054,
-0.056209031492471695,
0.014991452917456627,
-0.001649535377509892,
0.01930699497461319,
-0.03996928408741951,
-0.014943898655474186,
-0.028484949842095375,
-0.011044456623494625,
-0.008910463191568851,
0.00244160951115191,
0.0101706488057971,
0.010818574577569962,
0.021732257679104805,
-0.012756407260894775,
0.04225188493728638,
-0.0012074301484972239,
-0.018629347905516624,
-0.053926434367895126,
-0.029578696936368942,
-0.014099812135100365,
0.03193262591958046,
-0.0022261296398937702,
0.02900804579257965,
-0.007929658517241478,
-0.028722720220685005,
0.03283615782856941,
0.01263752207159996,
-0.012554301880300045,
0.034120120108127594,
-0.01497956458479166,
-0.01318439468741417,
0.0362125039100647,
-0.0187363438308239,
-0.015157893300056458,
-0.00588185666128993,
-0.01772581785917282,
0.018498573452234268,
-0.009796159341931343,
-0.01553832646459341,
0.01477745920419693,
-0.05249980837106705,
-0.05516284331679344,
0.045889776200056076,
-0.0005509596667252481,
-0.05497262626886368,
0.014801236800849438,
0.030957767739892006,
0.017904145643115044,
0.031243091449141502,
-0.013766933232545853,
0.030339563265442848,
0.03421522676944733,
-0.02415752038359642,
-0.006152321118861437,
-0.01282773818820715,
-0.006758636794984341,
0.039779067039489746,
-0.03780556842684746,
0.0338347963988781,
-0.016513187438249588,
0.0013560369843617082,
0.002695727162063122,
-0.01302984356880188,
0.00973077304661274,
0.01077102031558752,
-0.029673803597688675,
0.006877522449940443,
-0.009582165628671646,
0.014646685682237148,
0.011936097405850887,
-0.01442080270498991,
0.011454612016677856,
0.026820553466677666,
0.01811813935637474,
-0.003946996293962002,
0.01834402233362198,
-0.0009317646035924554,
0.028960492461919785,
0.016715291887521744,
0.014872567728161812,
-0.03533275052905083,
0.0016317025292664766,
0.016572630032896996,
-0.0013567800633609295,
0.005329039413481951,
-0.02615479566156864,
0.018332133069634438,
0.004817832261323929,
-0.019520988687872887,
0.05397398769855499,
-0.017856592312455177,
-0.014052257873117924,
-0.000563219771720469,
-0.03321659192442894,
-0.023800864815711975,
0.009189844131469727,
-0.008090153336524963,
-0.011466500349342823,
-0.03678315505385399,
0.028484949842095375,
-0.010836407542228699,
-0.0090174600481987,
-0.00841708853840828,
-0.0016227861633524299,
0.029935352504253387,
0.03171863406896591,
-0.015407552011311054,
0.010961237363517284,
0.02805696241557598,
0.039755288511514664,
0.024656839668750763,
0.004419566132128239,
-0.021316157653927803,
-0.023491762578487396,
0.0026556034572422504,
0.013969038613140583,
0.005997770000249147,
-0.017440492287278175,
-0.0381622239947319,
0.03343058377504349,
0.02279033698141575,
0.00458897789940238,
-0.027082102373242378,
-0.031433310359716415,
0.029198262840509415,
-0.00850625243037939,
0.05159628018736839,
-0.02710587903857231,
0.022837892174720764,
-0.010099317878484726,
-0.05487751588225365,
-0.022826002910733223,
0.0022112689912319183,
0.04322674497961998,
0.02056718058884144,
-0.02917448617517948,
0.037948232144117355,
-0.017511824145913124,
-0.006627862807363272,
-0.0010476779425516725,
0.030410893261432648,
0.001835293835029006,
0.03875664994120598,
0.038899313658475876,
0.04912346228957176,
-0.004083714447915554,
-0.006366314832121134,
-0.008595417253673077,
-0.01497956458479166,
0.011823156848549843,
0.03687826171517372,
-0.020210523158311844,
-0.027296096086502075,
0.034524329006671906,
-0.026345012709498405,
-0.004413621965795755,
0.013053620234131813,
0.03207528963685036,
0.01842724159359932,
-0.003373374231159687,
-0.0041074915789067745,
0.0742320641875267,
0.026630336418747902,
-0.014135478064417839,
0.0029988850001245737,
-0.004877274855971336,
0.015990091487765312,
0.013208171352744102,
0.025298820808529854,
0.001209659269079566,
-0.019366437569260597,
0.04555689916014671,
0.015466994605958462,
0.04974166676402092,
-0.015550214797258377,
-0.012482970952987671,
-0.012578078545629978,
0.0007608667947351933,
-0.006164209917187691,
-0.008999627083539963,
-0.01914055459201336,
0.015050895512104034,
0.03542786091566086,
0.010818574577569962,
-0.025441482663154602,
-0.03107665292918682,
0.014718016609549522,
-0.04099169746041298,
-0.030387116596102715,
-0.023253990337252617,
-0.007121237460523844,
0.029222039505839348,
-0.0033436529338359833,
-0.03297881782054901,
0.02296866662800312,
-0.001422167057171464,
-0.03597473353147507,
0.000491145474370569,
0.030696218833327293,
0.013719378970563412,
0.033882349729537964,
-0.02772408351302147,
0.023872194811701775,
-0.011341670528054237,
-0.021672815084457397,
0.013814487494528294,
-0.02558414451777935,
-0.03502364829182625,
0.013243837282061577,
-0.033002596348524094,
-0.01251863595098257,
0.015086561441421509,
0.0023078634403645992,
0.010348976589739323,
0.009849658235907555,
0.002336098812520504,
0.016251638531684875,
0.0037478632293641567,
0.002279628301039338,
-0.024847054854035378,
0.015443217940628529,
0.015027118846774101,
0.014064147137105465,
0.0022186993155628443,
0.001501671620644629,
-0.01323194894939661,
-0.00838142354041338,
-0.00942167080938816,
-0.0013679255498573184,
0.04657931253314018,
-0.0038697209674865007,
-0.011157398112118244,
-0.04042104631662369,
-0.028627611696720123,
0.0011784518137574196,
0.05249980837106705,
-0.025393929332494736,
0.019330771639943123,
0.003242600243538618,
-0.0036170892417430878,
-0.004009411204606295,
0.021827366203069687,
0.028389841318130493,
0.03856643661856651,
0.02168470248579979,
-0.012922846712172031,
0.02829473279416561,
0.017452381551265717,
0.014206808991730213,
-0.0008084209403023124,
-0.006841856520622969,
-0.0021770894527435303,
0.022826002910733223,
0.027129655703902245,
0.0022989471908658743,
0.015169781632721424,
-0.03820977732539177,
-0.00018984517373610288,
0.010640246793627739,
0.044700924307107925,
-0.003848915919661522,
0.004211516585201025,
-0.013041731901466846,
-0.0035279253497719765,
-0.010455974377691746,
0.03987417370080948,
-0.024193186312913895,
0.0037894733250141144,
0.005706500727683306,
0.0059829093515872955,
-0.008672692812979221,
-0.03169485554099083,
0.0029097211081534624,
0.024751948192715645,
0.015597769059240818,
-0.004859441891312599,
0.0011115787783637643,
0.02320643700659275,
-0.008553806692361832,
-0.030933989211916924,
0.02295677736401558,
-0.028960492461919785,
-0.012292753905057907,
-0.025703031569719315,
-0.01307739783078432,
-0.0011903403792530298,
-0.006437646225094795,
-0.012578078545629978,
-0.005055603105574846,
0.02035318687558174,
0.05516284331679344,
-0.014004704542458057,
-0.019723093137145042,
0.009243342094123363,
-0.01722649857401848,
-0.02255256660282612,
-0.03680692985653877,
0.046674422919750214,
-0.009047181345522404,
-0.04213299602270126,
0.030292008072137833,
0.006562476046383381,
-0.00606018491089344,
-0.018237026408314705,
0.010830462910234928,
0.0017580183921381831,
0.007513559423387051,
0.0028666250873357058,
0.02035318687558174,
-0.035641852766275406,
-0.014599131420254707,
-0.028033185750246048,
0.017809037119150162,
-0.025964578613638878,
0.0044819810427725315,
0.03138575330376625,
0.007400618400424719,
-0.025132380425930023,
-0.0156572125852108,
0.050264760851860046,
-0.0196398738771677,
0.016786623746156693,
0.005504395812749863,
-0.021256715059280396,
-0.0020180803257972,
0.030933989211916924,
0.010604580864310265,
0.019663650542497635,
-0.016322970390319824,
-0.003340680617839098,
0.004853497724980116,
0.0014667490031570196,
0.0077751073986291885,
-0.00691318791359663,
0.012447305023670197,
-0.02431207150220871,
-0.008946129120886326,
0.0036260057240724564,
0.01582365110516548,
0.047149963676929474,
-0.033240366727113724,
-0.06923887878656387,
0.055020179599523544,
0.03996928408741951,
-0.016501298174262047,
0.021827366203069687,
-0.01676284708082676,
0.015669099986553192,
0.02233857288956642,
-0.017832815647125244,
0.028556281700730324,
0.00687157828360796,
-0.036902040243148804,
-0.0024475539103150368,
0.014527800492942333,
0.01765448786318302,
0.023372875526547432,
-0.011204952374100685,
0.009909100830554962,
-0.0238365288823843,
0.031266868114471436,
-0.055495720356702805,
-0.0018100307788699865,
0.004996160510927439,
0.008482475765049458,
0.029982905834913254,
0.023955414071679115,
0.010551081970334053,
0.020769285038113594,
0.01323194894939661,
-0.006824024021625519,
0.01112173218280077,
-0.0036586993373930454,
-0.01946154609322548,
-0.0336921326816082,
-0.029269594699144363,
-0.02088817022740841,
0.023016219958662987,
0.003486315254122019,
-0.043107859790325165,
0.005991825833916664,
0.018558016046881676,
0.006865633651614189,
-0.005920494440943003,
-0.0291507076472044,
0.0026823526713997126,
0.013576716184616089,
-0.011383280158042908,
-0.020781174302101135,
-0.05792098492383957,
0.007246067281812429,
0.0008388853166252375,
-0.007561113685369492,
0.002019566250964999,
-0.01603764481842518,
0.0017981422133743763,
-0.0012386376038193703,
-0.002108730375766754,
0.0009971515974029899,
-0.020365074276924133,
-0.0023048913571983576,
-0.06890599429607391,
0.03759157285094261,
-0.016560740768909454,
0.010669968090951443,
-0.00021678015764337033,
-0.03297881782054901,
-0.024775724858045578,
-0.03224172815680504,
-0.0016391329700127244,
-0.006080990191549063,
-0.007323342841118574,
-0.021756034344434738,
-0.02233857288956642,
-0.0018813619390130043,
-0.004832692909985781,
-0.0016257583629339933,
-0.016156530007719994,
0.031980182975530624,
-0.009451392106711864,
0.016750957816839218,
-0.00528742978349328,
0.026321236044168472,
-0.050407424569129944,
0.04146723821759224,
-0.016394302248954773,
-0.004737584386020899,
-0.007578946650028229,
-0.004062909632921219,
-0.01931888237595558,
-0.022742783650755882,
0.0322892852127552,
0.00897585041821003,
0.000219938054215163,
-0.010402475483715534,
-0.014848791062831879,
-0.011258450336754322,
0.016976840794086456,
0.0256554763764143,
0.033097706735134125,
0.03003046102821827,
-0.02192247472703457,
0.0013211143668740988,
-0.014432691968977451,
-0.015003342181444168,
-0.03590340167284012,
0.002136965747922659,
0.020781174302101135,
0.011240617372095585,
-0.061059560626745224,
-0.009118513204157352,
0.01867690123617649,
0.029436033219099045,
0.0014125076122581959,
0.039779067039489746,
0.017737707123160362,
0.0203412976115942,
-0.0020106500014662743,
0.035618074238300323,
-0.001357523025944829,
0.03083888255059719,
0.01564532332122326,
-0.0009161608759313822,
0.02731987275183201,
-0.006128543987870216,
0.039779067039489746,
0.016893619671463966,
0.018534239381551743,
-0.019520988687872887,
-0.029578696936368942,
0.010455974377691746,
0.0025099688209593296,
0.0025129409041255713,
0.013850153423845768,
0.0510256290435791,
0.02701077051460743,
-0.017606932669878006,
0.011353558860719204,
-0.02240990474820137,
-0.0073292870074510574,
-0.010985014028847218,
-0.023479873314499855,
0.026630336418747902,
-0.021637149155139923,
-0.013148728758096695,
0.00801882240921259,
0.001532135996967554,
-0.009706995449960232,
0.013493496924638748,
0.003403095528483391,
0.005748110823333263,
-0.011775602586567402,
-0.014408914372324944,
0.019746869802474976,
0.03554674610495567,
-0.00997448805719614,
-0.0740894004702568,
-0.004196655936539173,
0.016548853367567062,
-0.02231479622423649,
0.00691318791359663,
0.0173334963619709,
0.03305014967918396,
0.04034971818327904,
-0.050264760851860046,
0.001552940928377211,
0.030054237693548203,
0.007893992587924004,
0.02105461061000824,
-0.0122333113104105,
-0.018890894949436188,
0.013006066903471947,
-0.017262164503335953,
-0.004957522731274366,
0.0004885448142886162,
-0.005225014872848988,
0.047625504434108734,
0.001890278421342373,
0.006829968187958002,
0.026582783088088036,
0.010711577720940113,
0.021161606535315514,
-0.01691739819943905,
-0.02748631313443184,
0.02225535362958908,
0.013303279876708984,
0.010343032889068127,
-0.02049584873020649,
-0.017357273027300835,
-0.0110801225528121,
-0.0005294117145240307,
-0.004776222165673971,
-0.004101547412574291,
-0.003881609532982111,
-0.00014832815213594586,
0.029293371364474297,
-0.0357845164835453,
-0.008809410966932774,
0.024823278188705444,
0.028508726507425308,
-0.011216840706765652,
-0.00007541794911958277,
0.022362349554896355,
0.018213247880339622,
-0.034120120108127594,
-0.04227565973997116,
0.016263527795672417,
-0.031052876263856888,
-0.003961856942623854,
0.03568940609693527,
-0.0012802474666386843,
0.02050773799419403,
0.0315997488796711,
0.025560367852449417,
-0.00024910212960094213,
-0.026915661990642548,
-0.005691640079021454,
0.0026689779479056597,
0.008197151124477386,
-0.016251638531684875,
-0.0302682314068079,
0.004529534839093685,
0.01890278421342373,
-0.01228086557239294,
-0.011008791625499725,
-0.020305631682276726,
0.020055972039699554,
-0.010289533995091915,
0.0134221650660038,
-0.013338945806026459,
0.00902340468019247,
-0.008958017453551292,
0.012025261297821999,
-0.012268977239727974,
-0.019259439781308174,
-0.027795415371656418,
-0.001985386712476611,
-0.01740482822060585,
0.01433758344501257,
-0.04888569191098213,
-0.005293373949825764,
0.019128667190670967,
-0.00791182555258274,
0.004419566132128239,
0.035950955003499985,
-0.010313311591744423,
0.0360698401927948,
-0.034357890486717224,
0.007662166375666857,
-0.017511824145913124,
0.023372875526547432,
-0.022683341056108475,
0.012060927227139473,
-0.011971763335168362,
0.00037040244205854833,
-0.028556281700730324,
-0.02693943865597248,
0.004805943462997675,
-0.017452381551265717,
-0.028223402798175812,
-0.014325695112347603,
-0.006086934357881546,
-0.005575726740062237,
-0.011662661097943783,
0.011989596299827099,
-0.0029632195364683867,
-0.0007786995847709477,
0.0012237769551575184,
0.022302906960248947,
0.0145753538236022,
0.059157393872737885,
-0.002658575540408492,
0.003744891146197915,
0.0005219813319854438,
0.006259317975491285,
-0.022647675126791,
0.014111701399087906,
0.054164204746484756,
0.001924457959830761,
0.019984642043709755,
0.016346747055649757,
-0.012494859285652637,
-0.03209906816482544,
0.012173868715763092,
-0.026083463802933693,
-0.006503033451735973,
0.005762971471995115,
-0.037639129906892776,
0.013541051186621189,
-0.02758142165839672,
0.016180306673049927,
-0.019342660903930664,
0.0025887303054332733,
-0.042465876787900925,
0.021970028057694435,
0.006247429642826319,
-0.014563465490937233,
-0.013243837282061577,
0.0013738698326051235,
-0.003340680617839098,
-0.003670587670058012,
0.027938077226281166,
-0.00171789457090199,
0.01028359029442072,
0.012530525214970112,
-0.01302984356880188,
-0.002569411415606737,
-0.04821993038058281,
-0.02653522975742817,
0.03918463736772537,
-0.028556281700730324,
-0.006330649368464947,
0.03478587791323662,
0.03421522676944733,
0.015455106273293495,
0.007073683198541403,
0.03946996480226517,
0.02106649801135063,
0.02430018223822117,
-0.059775594621896744,
-0.004892135504633188,
-0.021577706560492516,
0.023955414071679115,
0.09273064136505127,
-0.014860679395496845,
0.0000540557193744462,
-0.015609657391905785,
0.015419441275298595,
-0.00126092869322747,
0.03295504301786423,
0.020864393562078476,
0.0162159726023674,
0.004547367803752422,
0.017690151929855347,
-0.008345757611095905,
0.036426495760679245,
0.0162159726023674,
0.009255231358110905,
-0.01208470482379198,
0.02724854089319706,
0.02781919203698635,
0.003649782855063677,
0.009070958942174911,
-0.009962599724531174,
0.022231576964259148,
-0.017202721908688545,
0.020959502086043358,
-0.012173868715763092,
0.0011279255850240588,
-0.026630336418747902,
-0.01574043184518814,
-0.027533866465091705,
-0.025536591187119484,
-0.013327057473361492,
0.0011242104228585958,
0.031171761453151703,
-0.017190834507346153,
0.027700306847691536,
-0.0381622239947319,
-0.002725448692217469,
-0.006663528736680746,
0.007935603149235249,
-0.027938077226281166,
-0.0028502782806754112,
0.016964951530098915,
-0.028865383937954903,
0.021030833944678307,
-0.009986376389861107,
0.00015965942293405533,
-0.015383775345981121,
-0.008987738750874996,
0.021625259891152382,
-0.02105461061000824,
-0.008530030027031898,
-0.03395368158817291,
0.00744817266240716,
0.005510339979082346,
-0.02629745751619339,
-0.012839626520872116,
0.03186129778623581,
0.025203712284564972,
-0.019330771639943123,
-0.02271900698542595,
-0.007442228030413389,
0.03224172815680504,
0.0580160915851593,
0.014599131420254707,
0.04234699159860611
] | 2024-07-05 | 65 | 38966037 | [
"OTS T cell therapies",
"graft rejection",
"several clinical trials",
"alloreactive T cells",
"CD30",
"reduced cost",
"immediate availability",
"EBV)-specific T cells",
"many benefits",
"high levels",
"GVHD",
"Allogeneic EBVSTs",
"OTS",
"EBVSTs",
"host",
"access",
"lymphoma",
"Epstein",
"CAR",
"a chimeric antigen receptor",
"Epstein-Bar virus",
"fratricide",
"activation",
"the major challenges",
"the graft",
"the CD30.CAR",
"the treatment",
"a platform",
"the-shelf",
"We"
] | [
"CD30",
"MT: Regular Issue",
"allogeneic",
"alloreactive T cells",
"chimeric antigen receptor",
"immunotherapy",
"lymphoma",
"off-the-shelf",
"rejection",
"virus specific T cells"
] | 0 | 10.1016/j.omton.2024.200814
10.1200/JCO.2013.51.5304
10.1182/blood-2016-01-628982
10.1200/JCO.2018.77.8084
10.1038/nrc.2016.97
10.1038/nri3191
10.1038/mt.2016.106
10.1158/0008-5472.CAN-14-3321
10.1038/mt.2015.197
10.1158/1078-0432.CCR-16-1300
10.1182/blood-2012-01-405365
10.1126/scitranslmed.aaj2013
10.1182/blood-2013-06-506741
10.1182/blood-2013-02-486324
10.1182/blood-2010-06-289991
10.1038/bmt.2016.17
10.1200/JCO.2017.73.0655
10.1158/2326-6066.CIR-18-0508
10.5966/sctm.2015-0049
10.1186/s12967-019-1988-y
10.1038/s41587-020-0601-5
10.4049/jimmunol.169.4.1784
10.1097/00007890-199805150-00016
10.1038/bcj.2017.85
10.1007/s40259-013-0068-8
10.1172/JCI94306
10.1200/JCO.20.01342
10.1136/jitc-2022-006267
10.1097/CJI.0000000000000014
10.1097/MOH.0b013e3283590395
10.1080/14653240601078721
10.1182/blood-2004-12-4797
10.1038/nm0596-551
10.1158/1078-0432.CCR-16-2138
10.1007/s00262-021-03125-w
10.1038/s41467-019-08534-1
10.1016/S0140-6736(02)09672-1
10.1182/blood-2006-12-063008
10.1182/bloodadvances.2022007103
10.1172/JCI121127
10.1002/eji.202049107
10.1038/s41467-022-30896-2
10.1016/j.cellimm.2022.104497
10.1097/TP.0b013e3181e86b28
10.1182/blood-2006-11-059139
10.1038/s41591-018-0201-9
10.1155/2019/3616120
10.1186/s40425-019-0804-9
10.1158/2326-6066.CIR-14-0127
10.4049/jimmunol.1200356
10.1080/2162402X.2016.1253656
10.1172/JCI46110
10.1038/s41591-019-0421-7
10.1056/NEJMoa1106152
10.1007/978-0-387-89520-8_12
10.1155/2015/729654
10.1182/blood-2012-03-415422
10.1016/j.bbmt.2018.05.012
10.1182/blood-2017-03-772210
10.1182/blood-2006-04-017061
10.1158/2326-6066.CIR-18-0572 | [
"Quach",
"Ganesh",
"Briones",
"Nouraee",
"Ma",
"Hadidi",
"Sharma",
"Rooney"
] | [
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA.\nDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA.",
"Graduate program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, TX 77030, USA.\nDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston TX 77030, USA.\nDepartment of Molecular Virology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA."
] | [
"38966037",
"24344220",
"27207801",
"29812997",
"27550819",
"22437939",
"27203439",
"26183927",
"26502778",
"27815355",
"22535661",
"28123068",
"24030379",
"23610374",
"20709906",
"27042851",
"28783452",
"32321775",
"26285657",
"31340822",
"32661440",
"12165500",
"9603174",
"28885612",
"24043362",
"28805662",
"32701411",
"37072346",
"24714353",
"22954728",
"17148031",
"15755898",
"8616714",
"28183713",
"35001153",
"30718505",
"12241714",
"17468341",
"35819448",
"31689242",
"34323289",
"35773273",
"35248938",
"6448351",
"6223079",
"20595932",
"15557157",
"11070169",
"17507664",
"30275568",
"31565660",
"31779709",
"25212991",
"22956577",
"28180032",
"21540550",
"31011207",
"22047558",
"19760074",
"26090498",
"22661699",
"29758393",
"28473406",
"16926291",
"30651290"
] | [] | 8.30921 | 3.210978 |
38965396 | 760 | Emerging advances in defining the molecular and therapeutic landscape of small-cell lung cancer. | Small-cell lung cancer (SCLC) has traditionally been considered a recalcitrant cancer with a dismal prognosis, with only modest advances in therapeutic strategies over the past several decades. Comprehensive genomic assessments of SCLC have revealed that most of these tumours harbour deletions of the tumour-suppressor genes TP53 and RB1 but, in contrast to non-small-cell lung cancer, have failed to identify targetable alterations. The expression status of four transcription factors with key roles in SCLC pathogenesis defines distinct molecular subtypes of the disease, potentially enabling specific therapeutic approaches. Overexpression and amplification of MYC paralogues also affect the biology and therapeutic vulnerabilities of SCLC. Several other attractive targets have emerged in the past few years, including inhibitors of DNA-damage-response pathways, epigenetic modifiers, antibody-drug conjugates and chimeric antigen receptor T cells. However, the rapid development of therapeutic resistance and lack of biomarkers for effective selection of patients with SCLC are ongoing challenges. Emerging single-cell RNA sequencing data are providing insights into the plasticity and intratumoural and intertumoural heterogeneity of SCLC that might be associated with therapeutic resistance. In this Review, we provide a comprehensive overview of the latest advances in genomic and transcriptomic characterization of SCLC with a particular focus on opportunities for translation into new therapeutic approaches to improve patient outcomes. | [
0.00740419514477253,
0.03157323971390724,
0.06903835386037827,
0.013818915002048016,
-0.011435179971158504,
0.007100605871528387,
0.014628485776484013,
-0.011716281063854694,
-0.0048911538906395435,
-0.010805514641106129,
-0.011497022584080696,
-0.06508045643568039,
-0.005501142702996731,
0.01827155239880085,
-0.013290445320308208,
-0.024759357795119286,
0.033102430403232574,
-0.030763670802116394,
0.03858951851725578,
0.017506957054138184,
0.041917748749256134,
-0.017911743372678757,
-0.013065565377473831,
-0.025748832151293755,
-0.025703856721520424,
-0.011603840626776218,
0.0010154766496270895,
-0.0067464192397892475,
-0.011244031600654125,
0.025366535410284996,
0.02464691735804081,
-0.018665092065930367,
-0.02997658960521221,
0.01808040216565132,
-0.0557703971862793,
0.03404692932963371,
0.033529702574014664,
0.013908867724239826,
-0.0048630437813699245,
-0.00426148809492588,
0.01995815709233284,
0.010361375287175179,
-0.004286787007004023,
0.01902490109205246,
-0.02426462061703205,
-0.03395697474479675,
0.009057067334651947,
-0.07034265995025635,
-0.03148328885436058,
0.016854804009199142,
-0.021431123837828636,
-0.005574228707700968,
-0.020216768607497215,
0.03568855673074722,
-0.08990728110074997,
0.02356749027967453,
-0.014617240987718105,
-0.01065934170037508,
0.01033326517790556,
-0.018102891743183136,
0.014718437567353249,
0.0022417788859456778,
0.03022395819425583,
0.0007164556300267577,
-0.04610053077340126,
-0.00719055812805891,
0.010619987733662128,
-0.02646845020353794,
0.004700005054473877,
-0.010636853985488415,
0.007347974926233292,
-0.03892683982849121,
0.008472378365695477,
-0.0034238076768815517,
0.020632797852158546,
-0.016978487372398376,
0.028042614459991455,
0.042524926364421844,
-0.009939723648130894,
-0.007522257044911385,
0.014965806156396866,
-0.019036145880818367,
0.03739764913916588,
-0.005118845496326685,
-0.016146428883075714,
0.025456488132476807,
-0.005501142702996731,
0.029346922412514687,
-0.07196180522441864,
-0.007162448018789291,
-0.034878987818956375,
-0.0008018400403670967,
-0.03438425064086914,
0.05041823908686638,
-0.0009972050320357084,
0.008123813197016716,
0.045988090336322784,
-0.02909955382347107,
0.04306464269757271,
0.04254741594195366,
-0.012570827268064022,
0.02356749027967453,
0.0177543256431818,
-0.07079242169857025,
0.03546367585659027,
0.00899522565305233,
-0.03663305565714836,
-0.030898598954081535,
0.041917748749256134,
-0.019946912303566933,
0.02900960110127926,
0.006577758584171534,
-0.033282335847616196,
0.05617518350481987,
-0.04753976687788963,
-0.08869292587041855,
-0.054511066526174545,
-0.021847153082489967,
0.010125250555574894,
0.07843836396932602,
0.008230631239712238,
0.053206756711006165,
-0.00002593594035715796,
-0.032967500388622284,
0.010040920227766037,
-0.03499142825603485,
0.10254556685686111,
-0.052082356065511703,
-0.01398757565766573,
-0.04155794158577919,
0.009973456151783466,
-0.029211994260549545,
-0.013875135220587254,
-0.0018299662042409182,
-0.04592062532901764,
-0.020171793177723885,
-0.00810694694519043,
0.015022026374936104,
-0.021723469719290733,
-0.0038876240141689777,
-0.017461981624364853,
0.029999077320098877,
-0.0007941097719594836,
0.009394388645887375,
-0.03440673649311066,
-0.03168568015098572,
-0.0066789546981453896,
0.0024933640379458666,
-0.04610053077340126,
0.07304123044013977,
-0.00435706228017807,
0.03494644910097122,
0.02225193940103054,
0.021757202222943306,
-0.025546440854668617,
-0.038252197206020355,
-0.01230097096413374,
0.056579966098070145,
-0.03795985132455826,
-0.04515603184700012,
-0.0065833805128932,
0.018294040113687515,
-0.02047538198530674,
-0.015123222954571247,
0.03256271779537201,
-0.01154762040823698,
-0.0077471379190683365,
0.031325872987508774,
-0.026760796085000038,
-0.003243903163820505,
0.026963187381625175,
-0.059998154640197754,
-0.05154264345765114,
-0.004432959482073784,
-0.057659395039081573,
-0.027278020977973938,
0.04403162747621536,
-0.014887098222970963,
-0.03892683982849121,
-0.037645019590854645,
-0.013908867724239826,
0.053521592170000076,
0.046460337936878204,
0.0077190278097987175,
0.012357191182672977,
-0.013582790270447731,
-0.01827155239880085,
0.015662936493754387,
-0.01967705599963665,
-0.06962304562330246,
-0.02225193940103054,
-0.018012939020991325,
0.034271810203790665,
0.029459362849593163,
-0.020644042640924454,
0.037600040435791016,
0.05981824919581413,
0.07537999004125595,
-0.015325615182518959,
-0.008016994222998619,
0.029639268293976784,
0.027390461415052414,
-0.004241811111569405,
-0.0117612574249506,
-0.017169635742902756,
-0.013369154185056686,
-0.004098449368029833,
0.03519381955265999,
-0.02374739572405815,
0.035486165434122086,
0.025231607258319855,
0.02876223251223564,
0.003019022522494197,
0.011249653995037079,
-0.034744057804346085,
-0.015865329653024673,
-0.015291883610188961,
-0.007207424379885197,
0.02788519859313965,
0.011255275458097458,
0.038634493947029114,
0.02520911954343319,
-0.005959336645901203,
0.03233783692121506,
0.011806233786046505,
0.007094983942806721,
0.02469189465045929,
-0.021768445149064064,
0.02543400041759014,
-0.055680446326732635,
0.020138060674071312,
0.03467659279704094,
0.025186631828546524,
0.0030330775771290064,
-0.024579454213380814,
-0.025501463562250137,
-0.0015376213705167174,
0.004910830873996019,
0.0003264283004682511,
-0.035868462175130844,
0.0068476153537631035,
0.013886379078030586,
0.009917235933244228,
0.029122041538357735,
0.012593315914273262,
0.016809826716780663,
0.01110348105430603,
-0.041018228977918625,
-0.01779930293560028,
0.028874672949314117,
0.01297561265528202,
0.02802012674510479,
0.014572265557944775,
-0.02451198920607567,
0.022780409082770348,
-0.015303127467632294,
0.03454166650772095,
-0.04007373005151749,
0.021093804389238358,
-0.013335421681404114,
-0.025748832151293755,
-0.017967963591217995,
-0.0375775545835495,
-0.029819171875715256,
-0.031123479828238487,
-0.0068476153537631035,
0.04146799072623253,
-0.03220290690660477,
0.04803450405597687,
-0.031933050602674484,
0.02032920904457569,
0.0352163091301918,
0.0024652539286762476,
-0.03348472714424133,
-0.019002413377165794,
-0.03096606396138668,
0.0037976717576384544,
0.010069030337035656,
-0.039713919162750244,
0.049788571894168854,
-0.03334979712963104,
0.007291754707694054,
0.013054320588707924,
0.021813422441482544,
-0.005931226536631584,
0.019564615562558174,
0.008556707762181759,
-0.02853735350072384,
-0.02538902312517166,
-0.03465410694479942,
0.017821790650486946,
-0.012312214821577072,
-0.01466221734881401,
-0.0235225148499012,
-0.039938800036907196,
-0.016101453453302383,
0.04169287160038948,
-0.012413411401212215,
-0.03996128961443901,
0.06296657770872116,
-0.00686448160558939,
0.012323458679020405,
-0.01982322707772255,
-0.04292971268296242,
0.00337883154861629,
0.014752170071005821,
-0.017349541187286377,
-0.028379935771226883,
-0.001006340840831399,
0.02853735350072384,
0.017124660313129425,
0.022454330697655678,
0.030763670802116394,
-0.02957180328667164,
0.02075648307800293,
-0.0025523952208459377,
0.03404692932963371,
-0.021093804389238358,
0.033147405833005905,
-0.05379144847393036,
-0.04506608098745346,
-0.026176106184720993,
-0.021847153082489967,
0.029999077320098877,
0.0026564025320112705,
0.017495714128017426,
0.018350260332226753,
0.01986820437014103,
0.0690833330154419,
-0.021060071885585785,
0.01756317727267742,
-0.03222539648413658,
0.05379144847393036,
-0.005622015800327063,
-0.014167480170726776,
-0.06053786724805832,
-0.023320121690630913,
-0.030538789927959442,
0.02707562781870365,
0.03559860587120056,
-0.027660317718982697,
-0.012042357586324215,
-0.04358186572790146,
0.01977825164794922,
0.017124660313129425,
0.008438645862042904,
-0.016573702916502953,
0.04272732138633728,
0.021397393196821213,
0.030943576246500015,
0.05914360657334328,
0.05046321451663971,
0.015291883610188961,
-0.012525851838290691,
0.013661498203873634,
0.03087611123919487,
0.00302745564840734,
-0.02374739572405815,
0.05941346287727356,
0.016888536512851715,
0.001576975453644991,
-0.008916516788303852,
-0.03613831847906113,
0.04947374016046524,
0.02984165959060192,
0.049923501908779144,
-0.031595729291439056,
-0.018991170451045036,
-0.0304038617759943,
-0.014392361044883728,
0.022566771134734154,
-0.01808040216565132,
0.006262925919145346,
-0.00010286532051395625,
-0.01100790686905384,
0.008815321139991283,
-0.03044883720576763,
0.03658808022737503,
0.00267045758664608,
0.014684705063700676,
0.03454166650772095,
0.0076909177005290985,
-0.015370591543614864,
-0.0240397397428751,
-0.011671304702758789,
-0.0060773990117013454,
-0.0016008689999580383,
-0.025591416284441948,
-0.06085269898176193,
0.033664632588624954,
0.005414001177996397,
-0.008865918964147568,
0.03148328885436058,
-0.001253709546290338,
-0.01612394116818905,
0.03658808022737503,
-0.02712060511112213,
0.04673019424080849,
0.0485292412340641,
-0.011705037206411362,
0.018968680873513222,
-0.04578569903969765,
0.01574164442718029,
-0.02159978449344635,
0.011159701272845268,
-0.023320121690630913,
-0.0017695295391604304,
0.008163167163729668,
0.020272988826036453,
-0.0016388176009058952,
-0.008073214441537857,
0.04744981229305267,
0.037937361747026443,
0.0046409741044044495,
0.018541408702731133,
-0.06179719790816307,
-0.02164476178586483,
0.032967500388622284,
0.024849310517311096,
0.050957951694726944,
0.028267495334148407,
-0.044953640550374985,
0.016832316294312477,
-0.018957437947392464,
0.04288473725318909,
0.00774151599034667,
0.047854598611593246,
-0.012480875477194786,
-0.00373582961037755,
-0.048619192093610764,
-0.008534220047295094,
0.06368619948625565,
0.032495252788066864,
-0.032405298203229904,
-0.011092237196862698,
0.059908200055360794,
-0.012166042812168598,
-0.019452175125479698,
-0.013470349833369255,
-0.027210555970668793,
-0.008258741348981857,
0.0608077235519886,
-0.004432959482073784,
-0.03330482169985771,
0.04281727224588394,
-0.022611748427152634,
0.012986856512725353,
0.007482903078198433,
-0.028919650241732597,
-0.01201986987143755,
-0.0018974303966388106,
-0.025029214099049568,
-0.036902911961078644,
0.00883218739181757,
-0.03458664193749428,
-0.030426349490880966,
0.016270114108920097,
-0.10794270783662796,
0.015809109434485435,
-0.006611490622162819,
0.04493115097284317,
-0.018159111961722374,
-0.0268507469445467,
-0.029999077320098877,
-0.038207221776247025,
0.026715818792581558,
0.07155701518058777,
-0.02840242348611355,
0.012267238460481167,
0.014898342080414295,
0.04938378930091858,
-0.044481389224529266,
-0.026873236522078514,
0.02482682280242443,
-0.0016444396460428834,
0.05176752060651779,
0.011513888835906982,
0.019418442621827126,
0.03908425569534302,
0.012469631619751453,
0.0015601094346493483,
0.02267921157181263,
-0.0015207553515210748,
-0.04025363549590111,
0.026693331077694893,
0.012008626013994217,
-0.008095703087747097,
0.03575602173805237,
-0.010355752892792225,
0.03026893362402916,
0.007488525006920099,
-0.037172768265008926,
0.026086153462529182,
-0.00890527293086052,
-0.012267238460481167,
-0.04407660290598869,
-0.007938286289572716,
-0.00008538436668459326,
-0.03204549103975296,
0.007640319410711527,
0.015797864645719528,
0.03157323971390724,
-0.008298095315694809,
0.012863172218203545,
0.003215793054550886,
0.028267495334148407,
0.01587657257914543,
0.01616891846060753,
0.021903373301029205,
-0.006527160294353962,
-0.0226342361420393,
-0.009731709957122803,
0.012784464284777641,
-0.032697644084692,
-0.010923576541244984,
-0.013717718422412872,
-0.003676798427477479,
-0.022847872227430344,
0.035531140863895416,
-0.02923448197543621,
0.04396416246891022,
-0.013088053092360497,
0.0030246444512158632,
-0.015123222954571247,
0.012964368797838688,
-0.00007585329149151221,
0.005267828702926636,
-0.028357448056340218,
-0.01569666899740696,
-0.03519381955265999,
-0.0066901990212500095,
-0.021566053852438927,
0.009928479790687561,
0.03303496539592743,
-0.044301483780145645,
-0.0007470253622159362,
-0.01662992313504219,
-0.014617240987718105,
-0.040973253548145294,
-0.005936848931014538,
-0.00023348935064859688,
-0.0240397397428751,
0.016607435420155525,
-0.003069620579481125,
-0.02451198920607567,
0.00756723340600729,
-0.018721312284469604,
-0.008843431249260902,
0.012211018241941929,
-0.020317966118454933,
0.03256271779537201,
-0.03762253001332283,
0.02932443469762802,
-0.021341172978281975,
-0.005661369767040014,
-0.004587565083056688,
-0.00883218739181757,
0.012863172218203545,
-0.0009627701947465539,
-0.0200481079518795,
-0.020272988826036453,
0.0038314037956297398,
0.01426867675036192,
-0.02637849934399128,
0.023387586697936058,
-0.008118190802633762,
-0.007449171040207148,
0.015516763553023338,
-0.0007828657398931682,
0.022555528208613396,
-0.008281229063868523,
-0.02871725708246231,
0.0014392361044883728,
-0.04798952862620354,
0.025703856721520424,
-0.002338758669793606,
-0.02469189465045929,
0.004601620137691498,
0.00550395343452692,
-0.008410535752773285,
0.0018159111496061087,
-0.025996200740337372,
0.005464599467813969,
-0.005931226536631584,
-0.017866766080260277,
-0.0018580761970952153,
-0.018766289576888084,
-0.01030515506863594,
0.011305874213576317,
0.026693331077694893,
0.04454885423183441,
0.012199774384498596,
0.02010432817041874,
0.010957309044897556,
-0.019991887733340263,
0.007949530147016048,
0.024422036483883858,
-0.022150741890072823,
-0.05181249976158142,
-0.00810694694519043,
0.014819634146988392,
0.020261745899915695,
-0.002968424465507269,
-0.022409355267882347,
-0.029301946982741356,
0.01986820437014103,
0.011322739534080029,
-0.03955650329589844,
0.005970580969005823,
0.01056376751512289,
0.026580890640616417,
0.05284694954752922,
0.01115407980978489,
-0.049923501908779144,
0.04108569025993347,
0.02642347477376461,
-0.017405761405825615,
-0.023859836161136627,
0.01398757565766573,
-0.021903373301029205,
-0.022836629301309586,
0.003786427667364478,
-0.009085177443921566,
0.0002341921062907204,
0.03629573434591293,
-0.04825938493013382,
-0.014111259952187538,
-0.030808646231889725,
0.016382554545998573,
0.014549776911735535,
0.023365097120404243,
0.017922986298799515,
-0.008236253634095192,
0.02225193940103054,
0.023837346583604813,
-0.0017442303942516446,
0.04463880509138107,
0.0039016790688037872,
0.008056349121034145,
0.011266520246863365,
0.019755763933062553,
0.045988090336322784,
0.009338168427348137,
-0.01781054586172104,
0.0042783538810908794,
-0.027750270441174507,
0.008775967173278332,
-0.04740483686327934,
0.050058428198099136,
-0.02750290185213089,
-0.017922986298799515,
-0.01846270076930523,
0.044346462935209274,
0.016146428883075714,
0.008286851458251476,
0.04436894878745079,
-0.007083740085363388,
-0.002129338448867202,
0.05158761888742447,
0.06166227161884308,
-0.052307236939668655,
0.013818915002048016,
0.009759819135069847,
-0.016944756731390953,
-0.013537813909351826,
-0.002683107042685151,
0.024107204750180244,
-0.006937567610293627,
-0.0154605433344841,
-0.02736797370016575,
0.04713498055934906,
0.004351440351456404,
0.047809623181819916,
0.021431123837828636,
-0.006386610213667154,
0.010957309044897556,
0.021667249500751495,
-0.0001745460176607594,
-0.028897162526845932,
0.015179443173110485,
-0.004441392607986927,
0.007224290631711483,
-0.04020865634083748,
0.0000684304759488441,
-0.0316631942987442,
-0.009388766251504421,
-0.026356009766459465,
0.023904811590909958,
0.00773027166724205,
-0.017124660313129425,
0.00021100128651596606,
-0.020250501111149788,
0.0013057132018730044,
0.0007969207363203168,
-0.02230815961956978,
-0.01112596970051527,
0.007814601995050907,
-0.011328361928462982,
-0.027615342289209366,
-0.019317246973514557,
0.03629573434591293,
-0.007083740085363388,
-0.005560173653066158,
-0.018485188484191895,
0.011660060845315456,
0.0020731184631586075,
-0.035531140863895416,
-0.020115572959184647,
0.0037948607932776213,
-0.025029214099049568,
-0.02177968993782997,
-0.01485336571931839,
-0.039848849177360535,
-0.02520911954343319,
-0.03346223756670952,
-0.009180751629173756,
-0.023252658545970917,
-0.007769626099616289,
0.0004655731900129467,
-0.01040072925388813,
-0.007314242888242006,
-0.01911485381424427,
-0.036902911961078644,
-0.01611269824206829,
0.009827284142374992,
0.026918211951851845,
-0.04614550620317459,
0.06305652856826782,
-0.02070026285946369,
0.010698696598410606,
0.0076628075912594795,
-0.012615803629159927,
-0.019856959581375122,
-0.016517482697963715,
-0.02206079103052616,
0.008275607600808144,
-0.042569905519485474,
-0.0030049674678593874,
-0.0002422737452434376,
0.00941687636077404,
0.021757202222943306,
-0.04830436035990715,
-0.033237356692552567,
-0.004486368503421545,
-0.021611029282212257,
0.031325872987508774,
0.020812703296542168,
0.022240694612264633,
0.014257431961596012,
-0.013594034127891064,
0.00007295444083865732,
0.00648780632764101,
-0.0036852313205599785,
-0.04396416246891022,
0.000018414297301205806,
-0.007505391258746386,
-0.00852297618985176,
0.018170354887843132,
0.007960774935781956,
-0.013178004883229733,
-0.03161821886897087,
0.0038538919761776924,
0.0036655543372035027,
-0.027165580540895462,
-0.033754583448171616,
0.036520615220069885,
-0.0013696636306121945,
0.012593315914273262,
-0.0058187865652143955,
0.010709940455853939,
-0.02624356932938099,
-0.018192842602729797,
0.019710788503289223,
0.009675489738583565,
-0.02108255960047245,
0.02516414225101471,
0.004635352175682783,
0.00846113357692957,
-0.011311495676636696,
-0.006178595591336489,
0.029481850564479828,
0.0008011372410692275,
0.011884941719472408,
0.002586127258837223,
-0.02520911954343319,
-0.0007357813301496208,
0.009911613538861275,
0.02754787728190422,
-0.022195719182491302,
0.022004570811986923,
0.0035559250973165035,
0.049923501908779144,
-0.018192842602729797,
0.015865329653024673,
-0.025658881291747093,
0.014010063372552395,
0.010175848379731178,
-0.09543934464454651,
-0.007786491885781288,
0.0281100794672966,
-0.0003728099400177598,
-0.002196802757680416,
-0.000031426188797922805,
-0.030156493186950684,
0.008674770593643188,
0.004283976275473833,
-0.013391641899943352,
0.008579196408390999,
-0.021768445149064064,
-0.01426867675036192,
0.015707911923527718,
-0.02853735350072384,
-0.015494275838136673,
-0.021914618089795113,
-0.02043040655553341,
-0.003977576270699501,
-0.00017147148901131004,
0.005394324194639921,
0.04740483686327934,
-0.016427529975771904,
0.061392415314912796,
0.009456230327486992,
-0.010895466431975365,
-0.026828259229660034,
-0.012008626013994217,
-0.04047851264476776,
0.0019606780260801315,
0.00960240326821804,
0.01379642728716135,
-0.039106741547584534,
0.005065436474978924,
0.00016786987544037402,
-0.022892849519848824,
0.006066155154258013,
-0.03128089755773544,
-0.005273451097309589,
0.012143554165959358,
0.005096357315778732,
0.014369872398674488,
0.022454330697655678,
0.024467013776302338,
-0.0051497663371264935,
-0.03822970762848854,
-0.01492082979530096,
0.012233506888151169,
0.016191406175494194,
-0.031123479828238487,
0.030763670802116394,
-0.026715818792581558,
0.0013703664299100637,
-0.004961429163813591,
0.01790049858391285,
-0.01452728919684887,
0.0006922106840647757,
-0.0034659728407859802,
0.02993161231279373,
0.024759357795119286,
-0.0344742015004158,
0.017405761405825615,
0.030516302213072777,
0.018170354887843132,
-0.03415936976671219,
-0.029549315571784973,
-0.02712060511112213,
0.0032579582184553146,
-0.030538789927959442,
0.02239811047911644,
0.03645315021276474,
-0.0008805482648313046,
-0.06499050557613373,
0.05262206867337227,
-0.0022052356507629156,
-0.009265081956982613,
0.0126495361328125,
-0.019733276218175888,
-0.02473687008023262,
0.03622826933860779,
-0.03575602173805237,
-0.010501925833523273,
-0.002877066610381007,
0.007651563733816147,
-0.03355219215154648,
-0.00648780632764101,
0.0355086512863636,
0.011047260835766792,
0.014740925282239914,
-0.025478975847363472,
0.026625867933034897,
-0.028042614459991455,
-0.0021996137220412493,
0.013481593690812588,
-0.02824500761926174,
-0.0004125154227949679,
0.01440360490232706,
-0.02853735350072384,
-0.001485617714934051,
0.020913898944854736,
0.02374739572405815,
-0.021150024607777596,
-0.01887873001396656,
-0.004671895410865545,
0.011294630356132984,
-0.024422036483883858,
0.01808040216565132,
0.0023275145795196295,
-0.01818159967660904,
-0.01855265162885189,
0.02365744300186634,
-0.022285670042037964,
0.02655840292572975,
0.021105047315359116,
-0.0045004235580563545,
-0.005627637729048729,
0.039286646991968155,
-0.03143831342458725,
0.011013529263436794,
0.00979355163872242,
0.054556041955947876,
0.022836629301309586,
-0.024332085624337196,
0.013088053092360497,
-0.031190944835543633,
0.007887688465416431,
0.021262463182210922,
0.028559841215610504,
-0.025321559980511665,
0.011047260835766792,
0.034789033234119415,
0.01297561265528202,
0.01667489856481552,
-0.016596190631389618,
-0.0023570300545543432,
0.020205525681376457,
0.019384710118174553,
0.04099573940038681,
0.006785773206502199,
0.015438055619597435,
0.009636134840548038,
-0.006437208037823439,
0.0021841530688107014,
0.009804795496165752,
0.021262463182210922,
-0.01574164442718029,
-0.005711968056857586,
-0.007511013187468052,
-0.030291421338915825,
0.0069207013584673405,
0.026108641177415848,
-0.014965806156396866,
-0.009827284142374992,
0.03220290690660477,
-0.010642476379871368,
0.005321238189935684,
0.027727782726287842,
0.003294501220807433,
-0.03251773864030838,
0.013279201462864876,
-0.029077066108584404,
0.04056846722960472,
-0.05379144847393036,
-0.03161821886897087,
-0.00782022438943386,
0.013245468959212303,
-0.00037772918585687876,
-0.009360656142234802,
0.023882323876023293,
-0.005169443786144257,
-0.007494147401303053,
-0.07668429613113403,
0.04700005427002907,
-0.0316631942987442,
-0.014932074584066868,
0.03368711844086647,
0.006364122033119202,
0.009130153805017471,
0.0059480927884578705,
0.01827155239880085,
0.010175848379731178,
0.02056533470749855,
-0.007145582232624292,
0.06463069468736649,
0.047674693167209625,
-0.011446424759924412,
-0.023230168968439102,
-0.018069159239530563,
0.001949434052221477,
0.03555362671613693,
0.009203240275382996,
0.0010372619144618511,
0.03827468305826187,
0.012604559771716595,
0.03128089755773544,
-0.025411512702703476,
-0.033439751714468,
-0.00046381630818359554,
-0.015123222954571247,
-0.006094265263527632,
-0.019384710118174553,
0.05981824919581413,
0.05963834375143051,
0.015022026374936104,
-0.02849237620830536,
0.03809478133916855,
0.026738308370113373,
-0.04367182031273842,
-0.04695507511496544,
0.02646845020353794,
-0.007016276009380817,
0.006122375372797251,
-0.0298866368830204,
0.01827155239880085,
-0.010541279800236225,
-0.014639729633927345,
0.03260769322514534,
0.00462691904976964,
-0.05037326365709305,
-0.029032090678811073,
-0.0050317044369876385,
-0.049968477338552475,
0.000031426188797922805,
-0.013144273310899734,
-0.00932130217552185,
0.05824408307671547,
0.04407660290598869,
0.010012810118496418,
0.012166042812168598,
0.011305874213576317,
0.008303717710077763,
-0.004126559477299452,
0.04360435530543327,
0.009568670764565468,
-0.03044883720576763,
-0.011390204541385174,
0.03321487084031105,
-0.027480414137244225,
0.018800020217895508,
0.03978138417005539,
0.06800390779972076,
0.0038089158479124308,
-0.011064127087593079,
-0.02637849934399128,
-0.005385891068726778,
0.047944553196430206,
0.043087128549814224,
-0.06669959425926208,
-0.005616393871605396,
-0.007657185662537813,
0.020216768607497215,
-0.007758381776511669,
0.022049546241760254,
0.027480414137244225,
0.05586034804582596,
0.0275928545743227,
-0.01602274551987648,
-0.016888536512851715,
0.030291421338915825,
-0.018260307610034943,
-0.009231350384652615,
-0.012683267705142498,
-0.006572136655449867,
0.014156236313283443,
0.02797515131533146,
-0.003957899287343025,
-0.0041040717624127865,
-0.0014195590047165751,
0.014111259952187538,
0.010338887572288513,
-0.020452894270420074,
0.0008566546603105962,
-0.026153618469834328,
-0.0033900756388902664,
-0.014583509415388107,
0.006988165900111198,
-0.003404130693525076,
-0.022420600056648254,
0.00008657026046421379,
0.0032916902564466,
0.018024183809757233,
0.012042357586324215,
0.0015783809358254075,
0.02276916429400444,
0.007853955961763859,
-0.018777532503008842,
-0.040411051362752914,
-0.021195000037550926,
0.015258151106536388,
-0.05523068457841873,
-0.002990912413224578,
0.025501463562250137,
-0.0350588895380497,
-0.021487344056367874,
-0.03424932062625885,
-0.038859374821186066,
0.017698105424642563,
0.0168660469353199,
-0.0009051445522345603,
-0.013301689177751541,
0.0019367844797670841,
0.01742824912071228,
-0.015730399638414383,
0.019744519144296646,
-0.019182318821549416,
-0.002545367693528533,
-0.05743451416492462,
-0.036430664360523224,
0.0036318222992122173,
-0.0038173487409949303,
-0.04079334810376167,
0.021903373301029205,
-0.006611490622162819,
0.03939908742904663,
0.021026339381933212,
-0.01667489856481552,
-0.0058806287124753,
-0.002560828346759081,
0.00934941228479147,
0.00444982573390007,
0.0077752480283379555,
0.00048138509737327695,
0.0044554476626217365,
-0.023769883438944817,
-0.03737516328692436,
0.004981106147170067,
0.008944626897573471,
-0.009894748218357563,
-0.026041178032755852,
0.015606716275215149,
0.013110540807247162,
0.006926323752850294,
-0.011260897852480412,
0.03175314515829086,
0.018294040113687515,
0.036992862820625305,
0.023545002564787865,
-0.02586127258837223,
0.00497829494997859,
-0.007443549111485481,
-0.016360066831111908,
-0.01911485381424427,
-0.017158392816781998,
0.023814858868718147,
0.03733018413186073,
0.027255533263087273,
-0.003131462959572673,
0.002767437370494008,
-0.006009934935718775,
0.007814601995050907,
0.051092881709337234,
-0.007882066071033478,
-0.03265266865491867,
-0.011148457415401936,
0.02038542926311493,
0.019182318821549416,
-0.00784833449870348,
0.003572791116312146,
-0.020160548388957977,
0.03944406285881996,
-0.02788519859313965,
0.0792929083108902,
0.010889844968914986,
-0.010299532674252987,
0.028897162526845932,
-0.022476820275187492,
-0.009518072940409184,
-0.0002478957758285105,
0.015235663391649723,
-0.0035587360616773367,
-0.0024750924203544855,
0.039893824607133865,
-0.03307994082570076,
-0.02168973721563816,
-0.016843559220433235,
0.0052987500093877316,
0.038724444806575775,
0.021487344056367874,
-0.012098577804863453,
-0.0003125489456579089,
0.005141333676874638,
-0.012874416075646877,
0.0026409418787807226,
-0.022139498963952065,
-0.01917107403278351,
-0.031325872987508774,
-0.009276325814425945,
0.00003366621240274981,
0.014167480170726776,
0.002122310921549797,
0.002328920178115368,
-0.018057914450764656,
0.02057657763361931,
0.03026893362402916,
-0.01014773827046156,
-0.008219387382268906,
-0.0033956975676119328,
0.013200493529438972,
-0.0014019901864230633,
0.02183591015636921,
-0.047629717737436295,
-0.010822380892932415,
0.0015179442707449198,
-0.005841274280101061,
-0.005065436474978924,
0.016798583790659904,
0.005630448926240206,
0.0005175768164917827,
-0.03161821886897087,
0.009422498755156994,
-0.05064311996102333,
0.003541870042681694,
-0.029256971552968025,
0.024309596046805382,
-0.000025211227693944238,
-0.010001566261053085,
-0.011513888835906982,
-0.014617240987718105,
-0.019733276218175888,
0.018440211191773415,
-0.023814858868718147,
0.011148457415401936,
-0.0023738963063806295,
0.03008902817964554,
0.020554089918732643,
0.002884094137698412,
-0.013504082337021828,
0.020745238289237022,
-0.008506109938025475,
-0.017495714128017426,
0.012514607049524784,
-0.010108384303748608,
0.0069207013584673405,
0.011727524921298027,
-0.007038763724267483,
0.009225727990269661,
-0.011896185576915741,
0.00011050774628529325,
0.0015081057790666819,
0.025096679106354713,
0.00020590632630046457,
0.02619859389960766,
0.017911743372678757,
-0.008264363743364811,
0.0017878010403364897,
-0.026535915210843086,
-0.019890692085027695,
0.019058633595705032,
0.017023464664816856,
-0.0154605433344841,
0.008770344778895378,
0.010721184313297272,
0.003898868104442954,
-0.006544026546180248,
-0.013560302555561066,
0.01799045130610466,
-0.0350588895380497,
-0.030606254935264587,
0.012323458679020405,
-0.018721312284469604,
-0.03008902817964554,
-0.00019800037262029946,
-0.006279791705310345,
-0.021307440474629402,
0.004677517339587212,
0.02932443469762802,
-0.013605277985334396,
-0.0032916902564466,
-0.00995658989995718,
-0.002855984028428793,
-0.000680263910908252,
-0.013650254346430302,
-0.0019171073799952865,
-0.030471326783299446,
-0.0022783218882977962,
-0.027300508692860603,
0.012941880151629448,
0.030561277642846107,
-0.015336859039962292,
-0.004067528527230024,
-0.010805514641106129,
-0.00015223365335259587,
0.014954562298953533,
0.011750013567507267,
0.006307901814579964,
0.022409355267882347,
-0.01487585436552763,
-0.05127278342843056,
0.03883688524365425,
0.013639010488986969,
-0.0015699479263275862,
-0.008652282878756523,
-0.02651342749595642,
-0.014156236313283443,
-0.023342609405517578,
0.03616080433130264,
0.025276582688093185,
-0.040096215903759,
0.016236381605267525,
-0.015539252199232578,
0.010035298764705658,
0.01592154987156391,
0.0014715626602992415,
-0.021757202222943306,
0.005442111287266016,
0.03285505995154381,
-0.051992401480674744,
-0.05059814453125,
0.015662936493754387,
0.017878010869026184,
-0.010097140446305275,
0.0011862453538924456,
-0.009950968436896801,
0.0158315971493721,
0.02646845020353794,
0.03948903828859329,
-0.03265266865491867,
0.048799097537994385,
-0.00015407837054226547,
0.01977825164794922,
-0.011463290080428123,
0.0058637624606490135,
0.01808040216565132,
-0.03409190475940704,
-0.016427529975771904,
-0.01377393864095211,
-0.029999077320098877,
0.02374739572405815,
-0.03074118308722973,
-0.0030921087600290775,
0.03433927148580551,
-0.01412250380963087,
0.023230168968439102,
-0.032540228217840195,
-0.018732557073235512,
0.02745792642235756,
0.002586127258837223,
-0.002815224463120103,
-0.011215921491384506,
0.027390461415052414,
-0.004489179700613022,
0.019272269681096077,
-0.0012087334180250764,
-0.009394388645887375,
0.0029881014488637447,
-0.005062625277787447,
0.03341726213693619,
-0.010917955078184605,
0.002156043192371726,
0.0140550397336483,
-0.011873697862029076,
-0.022690456360578537,
0.0480794794857502,
0.007184936199337244,
-0.016719875857234,
-0.04306464269757271,
-0.004666273016482592,
-0.006909457501024008,
0.00034224020782858133,
0.02029547654092312,
0.02118375524878502,
-0.0009740142268128693,
-0.007972018793225288,
0.004258676897734404,
-0.007707783952355385,
0.013920111581683159,
0.010524413548409939,
0.00021433935035020113,
-0.02707562781870365,
0.02754787728190422,
0.007117472123354673,
-0.02028423361480236,
-0.01818159967660904,
-0.021611029282212257,
-0.036655545234680176,
0.02927945926785469,
-0.020351696759462357,
0.007432304788380861,
0.02202705852687359,
-0.025074191391468048,
-0.0069600557908415794,
-0.005936848931014538,
-0.012930636294186115,
-0.016326334327459335,
0.024579454213380814,
0.016461262479424477,
-0.0053156157955527306,
-0.026063665747642517,
-0.005858140531927347,
-0.03481152281165123,
-0.002071712864562869,
-0.015899060294032097,
0.004716871306300163,
0.03260769322514534,
0.001263548037968576,
0.019924424588680267,
0.006549648474901915,
-0.012379678897559643,
-0.025186631828546524,
-0.011187811382114887,
0.032585203647613525,
0.028177544474601746,
0.017731837928295135,
-0.033529702574014664,
-0.006234815809875727,
-0.0005439300439320505,
-0.019238539040088654,
-0.037600040435791016,
0.00356154702603817,
-0.003929789178073406,
0.0035587360616773367,
0.0004617080558091402,
0.013504082337021828,
0.003792049828916788,
-0.012896904721856117,
0.031033527106046677,
-0.039196696132421494,
-0.02853735350072384,
0.007432304788380861,
-0.00271121715195477,
0.017495714128017426,
0.02010432817041874,
-0.053161781281232834,
-0.0041490476578474045,
-0.0104681933298707,
0.024556964635849,
-0.04409909248352051,
0.007696539629250765,
0.011485778726637363,
0.015449299477040768,
-0.021150024607777596,
0.01878877729177475,
-0.018946193158626556,
-0.029459362849593163,
-0.01210982259362936,
0.0066339788027107716,
-0.02586127258837223,
0.025006726384162903,
-0.0406809076666832,
0.013582790270447731,
0.015977768227458,
0.018856240436434746,
-0.012829440645873547,
0.005501142702996731,
-0.02595122531056404,
0.01325671374797821,
-0.010187093168497086,
-0.00044343649642542005,
-0.01818159967660904,
-0.007055629976093769,
-0.008421779610216618,
-0.006600246764719486,
-0.005360592156648636,
0.05046321451663971,
-0.006589002441614866,
0.020868923515081406,
0.0009712032624520361,
0.0016388176009058952,
-0.026176106184720993,
-0.01379642728716135,
-0.0009761225082911551,
-0.02745792642235756,
-0.007033141795545816,
0.04540339857339859,
0.00026564026484265924,
0.005630448926240206,
0.028694769367575645,
0.005267828702926636,
-0.02880720980465412,
-0.0025088246911764145,
-0.00807883683592081,
-0.010203958489000797,
-0.01692226715385914,
0.009686733596026897,
0.0838804766535759,
-0.026828259229660034,
-0.021003851667046547,
0.007657185662537813,
-0.008376803249120712,
-0.02370241843163967,
0.009236971847712994,
-0.015111979097127914,
0.042659856379032135,
-0.01370647456496954,
0.02763783000409603,
0.010485059581696987,
0.0383196584880352,
0.03350721299648285,
0.01827155239880085,
-0.0022024246864020824,
0.04090578854084015,
0.03951152786612511,
-0.011069749481976032,
-0.037937361747026443,
-0.02043040655553341,
-0.0013724745949730277,
0.00523409666493535,
0.00642034225165844,
-0.019463419914245605,
-0.007516635116189718,
-0.007887688465416431,
-0.014684705063700676,
0.0010555335320532322,
-0.0014631296508014202,
0.022431842982769012,
0.010445705614984035,
0.0020801459904760122,
-0.029391899704933167,
0.0002252320118714124,
0.013818915002048016,
-0.03467659279704094,
-0.04310961812734604,
-0.02244308777153492,
0.01714714802801609,
0.014516045339405537,
-0.001576975453644991,
0.006915079429745674,
-0.00820252113044262,
0.01309929694980383,
-0.00782584585249424,
-0.025276582688093185,
0.015370591543614864,
0.014493556693196297,
-0.0021110670641064644,
0.017765570431947708,
0.027862710878252983,
0.023016532883048058,
0.012267238460481167,
-0.013953843154013157,
0.016247626394033432,
0.007139960303902626,
0.0027828977908939123,
0.016663655638694763,
-0.039376597851514816,
-0.01728207617998123,
0.008567952550947666,
-0.004823689814656973,
-0.03818473219871521,
0.006499050185084343
] | 2024-07-05 | 184 | 38965396 | [
"therapeutic resistance",
"new therapeutic approaches",
"specific therapeutic approaches",
"therapeutic strategies",
"therapeutic vulnerabilities",
"SCLC pathogenesis",
"SCLC",
"chimeric antigen receptor T cells",
"Comprehensive genomic assessments",
"Several other attractive targets",
"non-small-cell lung cancer",
"distinct molecular subtypes",
"Small-cell lung cancer",
"key roles",
"epigenetic modifiers",
"MYC paralogues",
"effective selection",
"Emerging single-cell RNA",
"patient outcomes",
"targetable alterations",
"ongoing challenges",
"patients",
"inhibitors",
"lack",
"TP53",
"RB1",
"biomarkers",
"MYC",
"insights",
"contrast"
] | [] | 0 | 10.1038/s41571-024-00914-x
10.1016/j.chest.2020.04.068
10.1097/JTO.0000000000000142
10.1038/s41598-017-01571-0
10.7150/jca.84600
10.1200/JCO.20.01055
10.1016/j.esmoop.2022.100408
10.1016/j.jtho.2023.09.025
10.1038/s41572-020-00235-0
10.1016/j.chest.2018.07.029
10.1158/0008-5472.CAN-06-2484
10.1016/j.pharmthera.2018.10.002
10.21037/jtd.2020.03.88
10.1200/JCO.1992.10.2.282
10.1200/JCO.2002.12.111
10.3389/fonc.2023.1142081
10.1016/j.esmoop.2021.100059
10.6004/jnccn.2022.7089
10.1200/JCO.18.01585
10.1158/2159-8290.CD-20-1863
10.1038/nature08629
10.1056/NEJMc1713444
10.1056/NEJMoa1809064
10.1016/j.ccell.2018.04.001
10.1084/jem.161.5.1135
10.1038/nature14664
10.1016/S1535-6108(03)00220-4
10.1158/1078-0432.CCR-22-1115
10.1158/2159-8290.CD-22-0620
10.1038/s41467-018-06162-9
10.18632/oncotarget.13362
10.1016/j.omto.2021.02.004
10.1038/nature13385
10.1038/nrclinonc.2017.127
10.1002/gcc.22076
10.1038/ng.2405
10.1158/2159-8290.CD-21-0441
10.1182/blood-2009-11-251074
10.1101/cshperspect.a014423
10.1038/nm.4107
10.1158/0008-5472.CAN-16-3409
10.1016/j.cllc.2021.04.005
10.1016/j.jtho.2019.10.013
10.1101/gad.340133.120
10.1080/15384047.2017.1360450
10.2147/IJGM.S342009
10.1126/science.aam7344
10.1200/PO.23.00190
10.1126/scitranslmed.abc7488
10.1038/gim.2015.30
10.1038/s41568-019-0133-9
10.1200/JCO.2021.39.15_suppl.8508
10.1016/j.jtho.2021.08.763
10.1016/j.ccell.2020.05.001
10.1016/j.jtho.2020.11.006
10.1016/j.jtho.2020.09.009
10.1016/j.ccell.2020.12.014
10.1038/s43018-020-0046-2
10.1093/nsr/nwab232
10.1016/j.celrep.2020.108296
10.1093/jnci/djw122
10.1016/j.isci.2021.103224
10.1016/j.ccell.2021.09.008
10.21037/tlcr.2018.02.02
10.1016/j.ccell.2019.06.005
10.1073/pnas.1915770117
10.1016/j.ccell.2021.02.014
10.1038/s41467-022-29517-9
10.1038/s41467-021-22336-4
10.1016/j.annonc.2021.05.799
10.1038/s41467-021-24164-y
10.1016/j.ccell.2024.01.010
10.1126/scitranslmed.aac9459
10.1016/j.jtho.2021.02.009
10.1172/JCI166028
10.1038/icb.2014.93
10.1158/1078-0432.CCR-20-2845
10.1200/JCO.22.02823
10.1056/NEJMoa2307980
10.1158/1078-0432.CCR-20-0926
10.1186/s13045-023-01464-y
10.3390/cancers13061292
10.1038/s41416-023-02219-9
10.1038/s41420-022-01296-8
10.1016/j.lungcan.2011.05.005
10.1200/JCO.2007.14.3461
10.1158/1078-0432.CCR-18-4140
10.1016/j.ccell.2019.10.001
10.1128/MCB.00248-19
10.1158/1538-7445.AM2022-3929
10.1016/j.ccell.2024.01.001
10.1101/gad.314815.118
10.1634/theoncologist.2016-0220
10.1002/cncr.30062
10.1200/JCO.2018.77.7672
10.1158/2159-8290.CD-19-0582
10.18632/oncotarget.20572
10.1111/cas.13078
10.1371/journal.pcbi.1007343
10.1038/ng.2396
10.1016/j.cell.2013.03.035
10.1073/pnas.1317023110
10.1016/j.isci.2021.102953
10.1016/j.cell.2017.06.010
10.1016/j.it.2020.08.010
10.1038/onc.2015.38
10.1038/s12276-022-00905-x
10.1158/2159-8290.CD-20-0913
10.1016/j.ccell.2019.08.008
10.1016/j.cell.2004.12.012
10.1126/scisignal.aau2922
10.1016/j.ccell.2015.06.002
10.1016/j.jtho.2019.06.021
10.1158/1078-0432.CCR-22-1128
10.1158/0008-5472.CAN-17-0570
10.1158/0008-5472.CAN-21-1114
10.1101/cshperspect.a038000
10.1126/scitranslmed.3002003
10.1038/nature12433
10.1101/gr.147942.112
10.1016/j.molcel.2020.10.033
10.1158/2159-8290.CD-15-0507
10.3389/fonc.2021.757323
10.1023/A:1011104509759
10.1186/s40170-021-00270-9
10.1016/j.ccell.2016.12.005
10.1016/j.metop.2021.100127
10.1016/j.ccell.2017.01.006
10.1038/nature22323
10.1111/1759-7714.12297
10.1016/j.isci.2022.105603
10.1007/s00262-013-1396-8
10.1158/1078-0432.CCR-16-1069
10.1080/14712598.2019.1592155
10.3390/cells9112393
10.1186/s40425-019-0690-1
10.1158/1078-0432.CCR-23-1689
10.1158/1538-7445.AM2023-CT080
10.1200/JCO.2023.41.16_suppl.8503
10.1093/annonc/mds213
10.1200/JCO.2016.67.6601
10.1016/S0140-6736(19)32222-6
10.1200/JCO.2017.72.5069
10.1200/JCO.20.00793
10.1200/JCO.23.01363
10.1016/j.cllc.2019.12.006
10.1200/JCO.2024.42.17_suppl.LBA5
10.1200/JCO.21.01308
10.1016/j.jtho.2023.09.024
10.1200/JCO.2024.42.16_suppl.8001
10.1016/j.jtho.2019.08.009
10.1158/1078-0432.CCR-17-1284
10.21037/tlcr.2018.02.03
10.3389/fonc.2020.00741
10.1016/j.celrep.2022.110814
10.1158/2159-8290.CD-18-1020
10.1158/1078-0432.CCR-22-2074
10.1186/s40364-022-00373-5
10.21037/tlcr-20-359
10.1111/j.1349-7006.2011.02093.x
10.3389/fimmu.2024.1348982
10.1016/j.jtho.2023.05.008
10.1200/PO.22.00257
10.1158/1541-7786.MCR-22-0881
10.1038/s41392-022-01150-4
10.1038/s43018-019-0020-z
10.1093/annonc/mdw005
10.1158/1535-7163.MCT-22-0365
10.1038/s41416-020-01202-y
10.1073/pnas.1205943109
10.1158/1078-0432.CCR-16-1040
10.1200/JCO.2023.41.16_suppl.8504
10.3389/fonc.2021.729765
10.1200/JCO.2023.41.16_suppl.8502
10.1200/JCO.2022.40.16_suppl.8566
10.1158/1535-7163.MCT-21-0851
10.1200/JCO.2023.41.16_suppl.3002
10.1002/ijc.31771
10.1016/j.annonc.2023.09.1221
10.1016/j.jtho.2023.09.042
10.3390/cancers2021236
10.1200/JCO.2010.33.3716
10.1002/cncr.29098
10.1038/nm.3600
10.3390/cancers13092265
10.3390/cancers13092029
10.1016/j.jtho.2019.10.007
10.1158/1078-0432.CCR-19-0879
10.1038/s41467-019-08570-x
10.1016/j.ccell.2020.03.012
10.1016/j.jtho.2017.09.1951
10.3390/cells9122586
10.1038/s43018-022-00415-9
10.1038/s41571-022-00660-y
10.7150/thno.34070
10.1056/NEJMoa1408617
10.3390/biomedicines9010048
10.1038/s41467-018-05327-w
10.1038/s41568-019-0199-4
10.1016/j.ccell.2023.08.007
10.1016/j.jtho.2019.04.026
10.1158/2159-8290.CD-17-0935
10.1634/theoncologist.2017-0659 | [
"Sen",
"Takahashi",
"Chakraborty",
"Takebe",
"Nassar",
"Karim",
"Puri",
"Naqash"
] | [
"Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [email protected].\nTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [email protected].",
"Department of Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.",
"Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.",
"Developmental Therapeutics Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA.",
"Division of Oncology, Yale University School of Medicine, New Haven, CT, USA.",
"Inova Schar Cancer Institute Virginia, Fairfax, VA, USA.",
"Division of Medical Oncology, Huntsman Cancer Institute, Salt Lake City, UT, USA.",
"Medical Oncology/ TSET Phase 1 program, University of Oklahoma, Oklahoma City, OK, USA. [email protected]."
] | [
"38965396",
"32464188",
"24828667",
"28465554",
"37325062",
"33439693",
"35279527",
"33446664",
"30080997",
"17440109",
"30291908",
"33209464",
"1310103",
"12488411",
"37188176",
"33640828",
"36791749",
"30550363",
"34155000",
"20016488",
"29262275",
"30280641",
"29731394",
"2580935",
"26168399",
"14522252",
"35792876",
"37062002",
"30224629",
"27863413",
"28857077",
"23716474",
"22941189",
"34344693",
"24890833",
"27213815",
"28490518",
"34034991",
"31655296",
"32820040",
"28812423",
"34992434",
"28302823",
"37992258",
"33504652",
"25741868",
"2985258",
"30926931",
"34534680",
"32473656",
"33248321",
"33011388",
"33482121",
"35121965",
"33086069",
"27247353",
"34712921",
"34653364",
"29535911",
"31287989",
"31871155",
"33848478",
"35440132",
"33824345",
"34162872",
"38366589",
"26311731",
"33607312",
"36951942",
"25367186",
"33203642",
"36689692",
"37861218",
"32554516",
"37355629",
"33799470",
"36918717",
"36588105",
"21620511",
"18281659",
"31164374",
"31679823",
"31501275",
"38278149",
"29945888",
"27694157",
"27163943",
"29906251",
"31416802",
"29088741",
"27627196",
"31671086",
"22941188",
"23582322",
"24127591",
"34466783",
"28753430",
"32976740",
"25746006",
"36509828",
"33707236",
"31564637",
"15620353",
"30723171",
"26175415",
"31260835",
"35920742",
"28935813",
"34341073",
"32900703",
"21430269",
"23925113",
"23325432",
"33217316",
"26382145",
"34745994",
"11398892",
"34556188",
"28089889",
"34590014",
"28196596",
"28489825",
"36483011",
"23589106",
"27620277",
"30855195",
"33142852",
"31383005",
"37801329",
"22858559",
"27458307",
"31590988",
"28813164",
"32468956",
"31948903",
"35108059",
"31470128",
"28698200",
"29535912",
"32509576",
"35584676",
"30777870",
"36378548",
"35418166",
"33569311",
"21895875",
"38533509",
"37210008",
"36044718",
"37256926",
"36195615",
"33521652",
"26802149",
"36399634",
"33328609",
"22927417",
"27440269",
"34568063",
"35642431",
"30152518",
"24281115",
"22253462",
"25336398",
"24880617",
"34066817",
"33922300",
"31629061",
"31300452",
"30696827",
"32289272",
"28951314",
"33287165",
"35941262",
"35915225",
"31534501",
"25426837",
"33430290",
"30082701",
"31519982",
"37699331",
"8843976",
"31063862",
"29483136",
"29650687"
] | [] | 7.395574 | 6.39422 |
38964917 | 761 | [Construction of CD138-targeted chimeric antigen receptor- modified T cells and their effect in multiple myeloma therapy]. | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-05 | 21 | 38964917 | [] | [
"Antigen recognition domain",
"CD138",
"Chimeric antigen receptor",
"Immunotherapy",
"Multiple myeloma"
] | 0 | 10.3760/cma.j.cn121090-20240131-00047
10.6004/jnccn.2022.0002
10.1182/blood-2014-09-568915
10.1016/S2352-3026(21)00057-0
10.1158/2159-8290.CD-12-0548
10.1186/1756-8722-6-47
10.1056/NEJMoa1407222
10.14670/HH-29.177
10.3892/ijo.2012.1545
10.18632/oncotarget.7079
10.1089/hum.2017.241
10.1200/JCO.2018.77.8084
10.1056/NEJMoa2024850
10.1016/S0140-6736(21)00933-8
10.1182/blood.2020008936
10.1038/s41408-023-00886-8
10.1182/blood.2022015526
10.1182/blood-2017-06-793869
10.1016/j.jocit.2014.11.001
10.1007/s00277-017-3029-3
10.1182/blood-2012-06-438002
10.1038/leu.2016.35 | [
"Guo",
"Lu",
"Tang",
"Xing",
"Tian",
"Rao",
"Wang",
"Xiong",
"Wang"
] | [
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.",
"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China."
] | [
"38964917",
"34991075",
"25838345",
"34048683",
"23550147",
"23829929",
"25317870",
"24150912",
"22766978",
"26840021",
"29409351",
"29812997",
"33626253",
"34175021",
"33512480",
"37558706",
"36095849",
"28928126",
"28577043",
"23243285",
"26898190"
] | [] | 32.986717 | 7.556798 |
|
38964783 | 762 | Genetically engineering glycolysis in T cells increases their antitumor function. | T cells play a central role in the antitumor response. However, they often face numerous hurdles in the tumor microenvironment, including the scarcity of available essential metabolites such as glucose and amino acids. Moreover, cancer cells can monopolize these resources to thrive and proliferate by upregulating metabolite transporters and maintaining a high metabolic rate, thereby outcompeting T cells.
Herein, we sought to improve T-cell antitumor function in the tumor vicinity by enhancing their glycolytic capacity to better compete with tumor cells. To achieve this, we engineered human T cells to express a key glycolysis enzyme, phosphofructokinase, in conjunction with Glucose transporter 3, a glucose transporter. We co-expressed these, along with tumor-specific chimeric antigen or T-cell receptors.
Engineered cells demonstrated an increased cytokine secretion and upregulation of T-cell activation markers compared with control cells. Moreover, they displayed superior glycolytic capacity, which translated into an improved in vivo therapeutic potential in a xenograft model of human tumors.
In summary, these findings support the implementation of T-cell metabolic engineering to enhance the efficacy of cellular immunotherapies for cancer. | [
-0.0013961949152871966,
0.039736054837703705,
-0.0020160365384072065,
0.019272316247224808,
0.004895301070064306,
-0.028020426630973816,
0.022250866517424583,
0.06054177135229111,
-0.005609601270407438,
-0.0092941764742136,
-0.009139733389019966,
-0.02735852636396885,
-0.01835668832063675,
-0.00004212285784888081,
0.01690050959587097,
-0.04981899634003639,
0.046730127185583115,
-0.027490906417369843,
0.01641511544585228,
0.01604004018008709,
0.03836812824010849,
-0.0171873327344656,
-0.03166087716817856,
0.0021953012328594923,
-0.05012788251042366,
-0.0012465780600905418,
0.014958936721086502,
0.004272012040019035,
-0.022041264921426773,
-0.04628886282444,
0.00053917255718261,
-0.01136261411011219,
-0.0064424918964505196,
-0.003036465495824814,
0.00907354336231947,
-0.00011385021934984252,
0.03750765696167946,
0.007016138173639774,
-0.02616710774600506,
0.004125842358916998,
0.008924616500735283,
-0.0004316138511057943,
0.007490499876439571,
0.09743165969848633,
-0.03430847451090813,
-0.012057608924806118,
-0.003753523575142026,
-0.05312849208712578,
-0.010011235252022743,
-0.0055516851134598255,
0.005267619621008635,
0.02504187636077404,
-0.044391416013240814,
0.04368538782000542,
-0.06535157561302185,
0.022129517048597336,
-0.019437791779637337,
-0.004294075071811676,
-0.02629948779940605,
0.009145249612629414,
-0.023365063592791557,
-0.008764657191932201,
0.06936710327863693,
0.03766210004687309,
-0.056526247411966324,
0.014738302677869797,
-0.04121429845690727,
0.011092337779700756,
-0.01639305241405964,
0.01779407449066639,
0.008102756924927235,
-0.03719877079129219,
-0.037397339940071106,
0.01089376863092184,
-0.003303983248770237,
-0.022769354283809662,
-0.011506025679409504,
0.019724614918231964,
-0.015400202944874763,
-0.04079509153962135,
0.03677956759929657,
-0.04317793250083923,
0.05078978091478348,
-0.02207436040043831,
-0.008163431659340858,
-0.023387128487229347,
0.021875789389014244,
-0.04273666441440582,
-0.07889845967292786,
-0.01704392023384571,
0.013844738714396954,
0.00518488185480237,
-0.011428804136812687,
0.0759861022233963,
0.0007660111878067255,
0.03532338887453079,
-0.006624514237046242,
-0.05127517506480217,
0.02585821971297264,
0.02629948779940605,
0.06852869689464569,
-0.029564859345555305,
-0.02627742290496826,
-0.02859407290816307,
0.06279223412275314,
0.0048787533305585384,
-0.05290786176919937,
0.028439629822969437,
0.0278218574821949,
0.0194046963006258,
0.08397302776575089,
0.016128292307257652,
0.0350806899368763,
0.030778342857956886,
-0.016161387786269188,
-0.048759955912828445,
-0.04823043569922447,
0.0016575074987486005,
0.0453622005879879,
0.02852788381278515,
-0.028285186737775803,
0.031484369188547134,
-0.022250866517424583,
-0.04412665590643883,
-0.010397342965006828,
-0.070602647960186,
0.07872195541858673,
-0.031197546049952507,
-0.036250047385692596,
0.016194483265280724,
0.04814217984676361,
-0.010617977008223534,
0.017827168107032776,
-0.000630183785688132,
-0.044016338884830475,
-0.02861613593995571,
-0.02349744364619255,
0.028373438864946365,
-0.015532582998275757,
0.005195913836359978,
-0.00861572939902544,
-0.01641511544585228,
0.028880896046757698,
-0.031947698444128036,
-0.04317793250083923,
-0.05568784102797508,
0.015135442838072777,
0.04580346867442131,
-0.01137364562600851,
0.030734214931726456,
-0.001177630154415965,
0.022570785135030746,
0.03803717717528343,
-0.012178957462310791,
0.00881429947912693,
-0.028858833014965057,
0.014539733529090881,
0.07889845967292786,
-0.02263697423040867,
-0.06535157561302185,
0.0037397341802716255,
0.03324943408370018,
-0.04024351015686989,
0.02136833220720291,
0.008654340170323849,
0.0018147086957469583,
-0.030800405889749527,
0.04611235484480858,
-0.05392277240753174,
0.002953727962449193,
-0.03823574632406235,
-0.04410459101200104,
-0.03839018940925598,
0.03636036440730095,
-0.05211358144879341,
-0.030337076634168625,
-0.010689682327210903,
0.011881101876497269,
-0.006061899475753307,
-0.01546639297157526,
-0.04108191654086113,
0.02013278752565384,
0.009713380597531796,
-0.0018533195834606886,
-0.00841715931892395,
0.017672725021839142,
-0.02017691358923912,
0.029233910143375397,
-0.0035108269657939672,
0.0010245657758787274,
-0.006519713439047337,
-0.01737487129867077,
0.03084453195333481,
-0.02859407290816307,
-0.053834520280361176,
0.00880326796323061,
0.037419404834508896,
0.010794483125209808,
-0.005204187706112862,
0.04721552133560181,
0.0035990802571177483,
-0.022184675559401512,
-0.009299692697823048,
-0.038213685154914856,
-0.013624104671180248,
-0.002970275469124317,
0.011406740173697472,
0.03748559579253197,
0.008240653201937675,
0.028638198971748352,
0.023276811465620995,
0.00005602016972261481,
-0.01036976370960474,
0.03020469658076763,
0.0018602142808958888,
-0.00012789835454896092,
-0.005129723809659481,
0.015675993636250496,
0.025681713595986366,
0.002859958913177252,
-0.05974749103188515,
-0.0010879978071898222,
0.011114401742815971,
0.008119304664433002,
-0.011594278737902641,
-0.02055199071764946,
-0.025637587532401085,
-0.01687844656407833,
-0.0064424918964505196,
-0.01760653592646122,
-0.007882123813033104,
-0.03439672663807869,
-0.00665209349244833,
-0.07254422456026077,
-0.02510806731879711,
0.008621245622634888,
0.011208171024918556,
-0.01329315546900034,
0.060012251138687134,
-0.04467823728919029,
-0.008422675542533398,
0.020044533535838127,
0.015609804540872574,
-0.005573748145252466,
-0.025615524500608444,
0.016757097095251083,
-0.01350275706499815,
-0.08600284904241562,
-0.007606332190334797,
-0.010921346955001354,
-0.030337076634168625,
0.01097650546580553,
-0.005648212041705847,
-0.004796016030013561,
0.017518281936645508,
0.02623329684138298,
0.03638242930173874,
-0.02146761864423752,
0.032256584614515305,
-0.022857608273625374,
0.02704964019358158,
0.028461692854762077,
-0.025240447372198105,
-0.03920653462409973,
-0.017198363319039345,
0.019768740981817245,
0.011848007328808308,
0.03287435695528984,
-0.009718895889818668,
0.03549989312887192,
0.046377114951610565,
0.010209805332124233,
0.049068842083215714,
-0.0341319665312767,
-0.03549989312887192,
-0.0014423900283873081,
-0.0008384064421989024,
0.03360245004296303,
-0.009244534187018871,
0.014219814911484718,
-0.01196935586631298,
0.01664678007364273,
0.021246984601020813,
-0.013072521425783634,
-0.042471908032894135,
-0.026475993916392326,
0.0010452502174302936,
0.026034727692604065,
0.007788354996591806,
-0.01896343007683754,
0.008952195756137371,
0.02588028460741043,
0.0050690495409071445,
-0.019162001088261604,
-0.019084779545664787,
0.010033298283815384,
-0.013579978607594967,
-0.02892502211034298,
-0.04238365218043327,
0.013999181799590588,
-0.007628395687788725,
-0.012443716637790203,
-0.050701528787612915,
-0.03556608408689499,
-0.014815525151789188,
0.008897037245333195,
0.011881101876497269,
-0.016889477148652077,
0.0423174612224102,
0.056129105389118195,
0.040486205369234085,
-0.007291929796338081,
0.05233421549201012,
0.011197138577699661,
0.012421653605997562,
0.005286925006657839,
0.02422553487122059,
-0.023607760667800903,
0.013745453208684921,
-0.018864145502448082,
-0.017705820500850677,
-0.028439629822969437,
-0.05290786176919937,
0.005535137373954058,
0.009829212911427021,
-0.028858833014965057,
0.011870070360600948,
0.028483755886554718,
0.019162001088261604,
-0.014032276347279549,
0.03920653462409973,
-0.014958936721086502,
0.050701528787612915,
-0.008538507856428623,
0.005565474275499582,
0.0025579670909792185,
-0.03364657610654831,
0.01802573911845684,
0.02422553487122059,
0.041346676647663116,
-0.011450867168605328,
0.003499795449897647,
-0.0355440229177475,
-0.0005195224075578153,
0.0413908027112484,
-0.006740346550941467,
0.020000407472252846,
0.02579203061759472,
-0.008731561712920666,
0.00861572939902544,
0.03574259206652641,
0.029675176367163658,
0.00879223644733429,
0.05440816655755043,
-0.025372827425599098,
0.016735034063458443,
-0.008400612510740757,
-0.0477009154856205,
0.037772417068481445,
-0.0006384575390256941,
-0.003508069086819887,
-0.0215117447078228,
-0.011627374216914177,
0.04417078197002411,
0.061291925609111786,
0.0477009154856205,
-0.01915096864104271,
0.025725839659571648,
-0.0073195090517401695,
0.004434728994965553,
-0.0390520915389061,
0.04880408197641373,
0.041302550584077835,
-0.021666187793016434,
-0.0540110282599926,
0.010430438444018364,
0.0036349333822727203,
0.015543614514172077,
0.0066686407662928104,
0.013249028474092484,
0.05127517506480217,
0.0016478548059239984,
0.01708804816007614,
-0.03481592983007431,
-0.056129105389118195,
-0.031947698444128036,
0.04452379420399666,
-0.014010213315486908,
-0.0979611724615097,
0.011274360120296478,
0.011980387382209301,
-0.0343746654689312,
0.0015982122858986259,
0.006905821617692709,
-0.0018450458301231265,
0.022769354283809662,
-0.039360977709293365,
0.0427807942032814,
0.05273135378956795,
0.01679019257426262,
-0.005841265898197889,
-0.007849029265344143,
-0.0278218574821949,
-0.06036526709794998,
-0.013955054804682732,
-0.04999550059437752,
0.02976342849433422,
0.02815280668437481,
0.026895197108387947,
0.00484014255926013,
-0.04503125324845314,
0.005394483916461468,
0.02209642343223095,
0.003155055921524763,
0.02389458380639553,
-0.04132461175322533,
-0.007975893095135689,
0.029057402163743973,
-0.0054524000734090805,
0.01873176544904709,
-0.024026963859796524,
-0.024159343913197517,
0.02263697423040867,
-0.01545536145567894,
-0.02013278752565384,
-0.0005295198643580079,
0.013149743899703026,
-0.00047125888522714376,
-0.021754441782832146,
-0.07192645221948624,
-0.031109292060136795,
0.02464473806321621,
-0.0018933092942461371,
-0.03808130323886871,
-0.00578059209510684,
0.010353216901421547,
0.0036487227771431208,
-0.025615524500608444,
-0.04216301813721657,
0.008058630861341953,
-0.056570373475551605,
0.027182020246982574,
0.03313911706209183,
-0.06120367348194122,
0.006431459914892912,
0.042869046330451965,
-0.010380796156823635,
-0.00031164451502263546,
0.016426147893071175,
-0.0018450458301231265,
0.06914646923542023,
-0.014032276347279549,
0.0008763278019614518,
0.011693564243614674,
-0.03565433621406555,
0.007689069956541061,
0.03825781121850014,
-0.04097159951925278,
0.032256584614515305,
-0.0046470882371068,
0.02663043700158596,
-0.038522571325302124,
-0.0324992835521698,
-0.049510106444358826,
-0.019371602684259415,
0.02735852636396885,
0.024402040988206863,
0.005391725804656744,
-0.008643308654427528,
-0.029233910143375397,
0.035830844193696976,
-0.012763635255396366,
-0.023651886731386185,
0.025350764393806458,
-0.04494299739599228,
0.05723227187991142,
0.017783042043447495,
0.01312767993658781,
0.04430316388607025,
-0.016051070764660835,
0.001708528958261013,
-0.03322737291455269,
-0.042802855372428894,
0.011958323419094086,
-0.008897037245333195,
-0.0015389170730486512,
0.011726658791303635,
-0.035411641001701355,
-0.02930009923875332,
0.00665209349244833,
-0.001714044832624495,
-0.02899121306836605,
0.029432479292154312,
-0.008268232457339764,
-0.0309769120067358,
0.004012767691165209,
-0.005951582919806242,
0.01446251105517149,
-0.002611746545881033,
0.026387739926576614,
-0.011682531796395779,
0.02941041626036167,
-0.009018384851515293,
0.014374257996678352,
0.021798567846417427,
0.01069519855082035,
0.022438405081629753,
0.04668600112199783,
0.004881511442363262,
0.012785698287189007,
-0.00008790857100393623,
-0.03369070217013359,
0.033072929829359055,
0.035389579832553864,
-0.004702246747910976,
-0.0027413684874773026,
-0.014197751879692078,
0.01610622927546501,
-0.00409826310351491,
0.0009735443745739758,
-0.01391092874109745,
-0.03406577929854393,
-0.02274729125201702,
-0.005209703464061022,
0.01774994656443596,
-0.02819693274796009,
-0.03830193728208542,
-0.010799999348819256,
-0.035389579832553864,
-0.039713989943265915,
0.011318487115204334,
-0.015675993636250496,
0.02854994684457779,
0.03283023089170456,
-0.008257200941443443,
-0.029961999505758286,
-0.02382839471101761,
0.01697773113846779,
-0.014021244831383228,
-0.03260960057377815,
0.005918487906455994,
0.01819121465086937,
0.0453622005879879,
0.03358038514852524,
0.01488171424716711,
0.01618345081806183,
0.004269253928214312,
-0.036603059619665146,
-0.019515013322234154,
-0.027557097375392914,
0.03174912929534912,
-0.03331562504172325,
0.02660837396979332,
-0.03715464472770691,
-0.00791521929204464,
0.010215320624411106,
-0.007479468360543251,
-0.019680488854646683,
-0.002233912004157901,
0.004335443954914808,
-0.020960161462426186,
-0.0049918279983103275,
0.007843513041734695,
-0.038191620260477066,
-0.005504800472408533,
0.007931766100227833,
-0.017352808266878128,
-0.0021056688856333494,
-0.010640040040016174,
0.05211358144879341,
-0.00665760925039649,
0.009707864373922348,
-0.0006915474077686667,
-0.015345044434070587,
0.060806531459093094,
0.015565677545964718,
-0.03324943408370018,
-0.009785085916519165,
0.024424104019999504,
0.014440448023378849,
0.009040448814630508,
0.0027275788597762585,
-0.006883758120238781,
0.024335850030183792,
-0.011075790971517563,
-0.0059681301936507225,
-0.030778342857956886,
0.012631255201995373,
-0.008229621686041355,
-0.01902962103486061,
-0.00014866891433484852,
-0.0015513277612626553,
0.0017719609895721078,
0.005471705459058285,
-0.03124167211353779,
0.015907660126686096,
0.0037121549248695374,
-0.005135239567607641,
-0.0074960156343877316,
0.007507047150284052,
0.011004084721207619,
-0.0007887639803811908,
0.004666394088417292,
-0.028064552694559097,
-0.04273666441440582,
0.0477009154856205,
0.008897037245333195,
-0.014793461188673973,
-0.024159343913197517,
-0.002322165295481682,
0.040861282497644424,
0.014341163448989391,
-0.06433666497468948,
-0.04432522505521774,
0.011219202540814877,
-0.010413890704512596,
-0.005962614435702562,
0.021710313856601715,
0.03726496174931526,
0.00860469788312912,
0.023365063592791557,
-0.025659650564193726,
-0.0026806944515556097,
-0.026365676894783974,
-0.01528988592326641,
-0.051407553255558014,
-0.033050864934921265,
0.0032019405625760555,
-0.00965822208672762,
0.0029068435542285442,
0.008317874744534492,
-0.0062659853138029575,
-0.01873176544904709,
0.03865494951605797,
-0.003519100835546851,
0.0021056688856333494,
0.014407353475689888,
-0.005907455924898386,
0.005526863504201174,
-0.003794892458245158,
0.020276198163628578,
-0.011252297088503838,
0.012013481929898262,
-0.011428804136812687,
0.015433297492563725,
0.011340550146996975,
-0.027932172641158104,
0.010430438444018364,
0.02268110029399395,
-0.023740140721201897,
0.021258017048239708,
-0.049554236233234406,
0.01310561690479517,
0.015234728343784809,
0.011103370226919651,
0.014793461188673973,
-0.0019305412424728274,
-0.03519100695848465,
0.043619200587272644,
0.012531970627605915,
-0.03836812824010849,
0.013249028474092484,
-0.007071296684443951,
0.004219611641019583,
-0.03375689312815666,
-0.016426147893071175,
-0.0008308222168125212,
0.006470071151852608,
0.011980387382209301,
-0.01739693433046341,
0.056526247411966324,
0.011748721823096275,
0.03208008036017418,
-0.0493336021900177,
-0.016712971031665802,
0.04615648090839386,
0.020618179813027382,
-0.04973074048757553,
-0.02932216227054596,
0.0367133766412735,
-0.01877589151263237,
-0.007109907455742359,
-0.01308355387300253,
-0.033094990998506546,
0.015036158263683319,
-0.0062218583188951015,
-0.02159999869763851,
0.0032046984415501356,
0.011384677141904831,
-0.014969968236982822,
-0.004249948542565107,
0.006288048345595598,
-0.025681713595986366,
-0.034551169723272324,
-0.004980796482414007,
-0.020540958270430565,
0.007694585714489222,
0.01425290945917368,
-0.01270847674459219,
-0.05211358144879341,
0.025328701362013817,
0.03252134472131729,
-0.0029316646978259087,
-0.019702551886439323,
0.02015485055744648,
-0.006304596085101366,
0.010000203736126423,
0.005267619621008635,
0.015422265976667404,
-0.003243309212848544,
-0.024004900828003883,
0.007887640036642551,
0.0073195090517401695,
-0.022405309602618217,
-0.0018202245701104403,
-0.022173644974827766,
0.0014017107896506786,
0.042074766010046005,
0.05374626815319061,
0.023762203752994537,
-0.008847394958138466,
-0.0150802843272686,
0.01564290001988411,
0.00027699818019755185,
0.04181000590324402,
-0.0033922367729246616,
0.008466802537441254,
0.04492093622684479,
-0.009068028070032597,
0.010309089906513691,
0.028858833014965057,
-0.0062439218163490295,
-0.026431865990161896,
-0.03441879153251648,
-0.013602041639387608,
-0.0062659853138029575,
-0.04037588834762573,
-0.06058589741587639,
0.011594278737902641,
-0.005929519422352314,
0.010480080731213093,
-0.05281960591673851,
-0.002862716792151332,
0.010855156928300858,
-0.012355463579297066,
0.003585290862247348,
0.03044739179313183,
0.02660837396979332,
0.003166087670251727,
-0.05127517506480217,
-0.014980999752879143,
0.0057695601135492325,
-0.02471092715859413,
0.014517669565975666,
-0.0018698670901358128,
-0.046332988888025284,
0.011759753338992596,
0.00004332944445195608,
-0.0043768128380179405,
-0.02146761864423752,
-0.03801511228084564,
-0.005874360911548138,
-0.015157505869865417,
-0.007385699078440666,
0.01330418698489666,
0.011737690307199955,
0.013447598554193974,
-0.007931766100227833,
0.0027386106085032225,
0.027226146310567856,
-0.015157505869865417,
-0.030734214931726456,
0.005595811642706394,
-0.04183207079768181,
-0.0002616572892293334,
-0.0074960156343877316,
-0.025174256414175034,
-0.015554646030068398,
0.03049151971936226,
0.01310561690479517,
-0.027314400300383568,
-0.00839509628713131,
-0.05630561336874962,
-0.002661388833075762,
0.009062511846423149,
-0.03252134472131729,
0.016095196828246117,
0.03084453195333481,
-0.0018946882337331772,
-0.03170500323176384,
-0.018489068374037743,
0.03730908781290054,
-0.03766210004687309,
0.0523783415555954,
-0.02581409364938736,
0.019537076354026794,
0.0278218574821949,
-0.0619538240134716,
-0.02821899577975273,
0.00218564854003489,
0.0026448413264006376,
-0.00015970057575032115,
0.0007949692662805319,
-0.011947291903197765,
-0.010827578604221344,
0.014605923555791378,
-0.035477831959724426,
-0.0034694583155214787,
0.002851685043424368,
0.034220222383737564,
-0.015951786190271378,
0.012443716637790203,
0.024975687265396118,
-0.020706433802843094,
-0.020419610664248466,
0.00862676091492176,
0.00773319648578763,
-0.037066392600536346,
0.011241265572607517,
-0.006635545752942562,
0.007148518227040768,
0.02008865959942341,
0.022945860400795937,
-0.025659650564193726,
-0.012796729803085327,
-0.027932172641158104,
-0.055378954857587814,
-0.004164453130215406,
0.016558527946472168,
-0.0039934623055160046,
0.03291848674416542,
-0.02230602502822876,
-0.04300142452120781,
0.029255973175168037,
-0.005736465100198984,
0.010342185385525227,
-0.013028395362198353,
0.007832481525838375,
-0.023982837796211243,
0.031837381422519684,
0.015179569832980633,
-0.031947698444128036,
-0.0004260980349499732,
-0.032697852700948715,
-0.033072929829359055,
-0.017275584861636162,
0.004216853529214859,
0.030359139665961266,
-0.020684370771050453,
-0.03803717717528343,
0.016315830871462822,
-0.016525432467460632,
-0.0031964245717972517,
0.022339118644595146,
0.030248822644352913,
0.008516444824635983,
0.00015461567090824246,
-0.036603059619665146,
0.04624473676085472,
0.01524575985968113,
0.0006918921717442572,
0.004310622811317444,
0.0050552599132061005,
-0.012443716637790203,
0.0533050000667572,
-0.013392440043389797,
0.004567109048366547,
-0.015234728343784809,
0.02199713885784149,
-0.012366495095193386,
0.04646536707878113,
0.001065245014615357,
0.006883758120238781,
0.0028351375367492437,
0.02109254151582718,
-0.01392196025699377,
0.0054524000734090805,
-0.010513176210224628,
0.018433909863233566,
-0.007098875939846039,
0.042493969202041626,
-0.004980796482414007,
0.022394277155399323,
0.005708886310458183,
0.03938303887844086,
0.014175687916576862,
-0.020055565983057022,
0.0015016852412372828,
-0.031947698444128036,
-0.009487231262028217,
0.024556484073400497,
0.022813480347394943,
-0.008941163308918476,
-0.04260428622364998,
0.00988988671451807,
0.012840856797993183,
0.00033077754778787494,
0.04258222132921219,
0.0154884560033679,
-0.0024752295576035976,
-0.022813480347394943,
0.013944023288786411,
0.0008763278019614518,
0.023696014657616615,
0.013403471559286118,
-0.014694176614284515,
-0.04458998516201973,
0.0063211433589458466,
-0.007639427203685045,
0.01917303167283535,
-0.0001324661570833996,
-0.016359956935048103,
0.003155055921524763,
0.015565677545964718,
-0.033448006957769394,
-0.00752911064773798,
-0.026012662798166275,
0.06385127454996109,
0.042824920266866684,
-0.01312767993658781,
0.00268345233052969,
-0.011936260387301445,
0.018080897629261017,
0.012234115041792393,
-0.012035544961690903,
-0.019305411726236343,
0.00986782368272543,
-0.014903778210282326,
-0.004238917026668787,
0.027667412534356117,
0.011213686317205429,
-0.04381776973605156,
0.04527394846081734,
0.003750765696167946,
0.03549989312887192,
0.028880896046757698,
0.016955668106675148,
0.00879223644733429,
-0.02735852636396885,
0.002054647309705615,
0.0015458118868991733,
-0.00010954097524518147,
-0.012664350681006908,
-0.020871907472610474,
0.005659243557602167,
0.010402859188616276,
-0.03752972185611725,
0.0013155259657651186,
0.022405309602618217,
0.0332053080201149,
0.05604085326194763,
-0.024578547105193138,
-0.009465167298913002,
0.017032889649271965,
0.008064146153628826,
-0.027954235672950745,
0.016547495499253273,
-0.026784880086779594,
0.049112968146800995,
-0.03719877079129219,
-0.029035339131951332,
-0.02859407290816307,
-0.02614504285156727,
-0.02852788381278515,
0.033403877168893814,
0.04417078197002411,
0.0012072777608409524,
-0.03091072291135788,
-0.05604085326194763,
0.0413908027112484,
0.002706894651055336,
-0.011483962647616863,
0.003976915031671524,
0.009387945756316185,
0.036250047385692596,
0.0146721126511693,
0.027137894183397293,
0.017099078744649887,
0.0050001018680632114,
0.034242283552885056,
-0.005435852333903313,
0.05242246761918068,
-0.05052502080798149,
-0.006916853133589029,
-0.014043307863175869,
-0.0022945860400795937,
0.010689682327210903,
-0.041677627712488174,
-0.004385086242109537,
0.012653318233788013,
0.014286004938185215,
0.037772417068481445,
-0.007959345355629921,
-0.007854544557631016,
0.014727271161973476,
-0.03825781121850014,
-0.0012127935187891126,
-0.003601838368922472,
0.00833442248404026,
0.026431865990161896,
-0.041677627712488174,
-0.014793461188673973,
0.03889764845371246,
0.015907660126686096,
-0.03477180376648903,
-0.032300710678100586,
0.055731967091560364,
-0.0016575074987486005,
0.049907248467206955,
-0.019559139385819435,
0.0121017349883914,
0.013039426878094673,
-0.00685617933049798,
0.011649437248706818,
-0.01048559695482254,
-0.031175483018159866,
0.00834545399993658,
-0.007087843958288431,
-0.014197751879692078,
-0.011693564243614674,
0.003954851534217596,
-0.002399386838078499,
0.0037259445525705814,
0.01998937502503395,
-0.005273135378956795,
-0.007032685913145542,
0.040442079305648804,
-0.02779979258775711,
0.03596322610974312,
-0.004219611641019583,
0.029454542323946953,
0.015951786190271378,
0.04686250910162926,
-0.01506925281137228,
-0.037728291004896164,
-0.008295811712741852,
0.003066802630200982,
0.022581815719604492,
0.04335444048047066,
0.002244943520054221,
-0.04030970111489296,
-0.024026963859796524,
-0.00450643477961421,
0.03843431547284126,
-0.029851682484149933,
0.00026079543749801815,
-0.010033298283815384,
-0.03558814898133278,
0.02733646333217621,
-0.00947068352252245,
0.011660468764603138,
0.03280816972255707,
0.0206954013556242,
0.010860673151910305,
0.003662512404844165,
0.02693932317197323,
-0.01793748512864113,
0.0051766084507107735,
-0.006563839968293905,
-0.005477221217006445,
-0.024402040988206863,
0.023387128487229347,
-0.008378548547625542,
-0.013160775415599346,
-0.03095484897494316,
0.015223695896565914,
0.027579160407185555,
0.03091072291135788,
0.023563634604215622,
0.0020877423230558634,
-0.0046167513355612755,
0.003681817790493369,
-0.01704392023384571,
0.03552195802330971,
-0.005297956522554159,
0.0067899893037974834,
-0.043222058564424515,
-0.031859446316957474,
0.006332175340503454,
0.01156118419021368,
0.030668025836348534,
0.024049026891589165,
0.019117873162031174,
-0.019559139385819435,
0.003593564499169588,
0.01781613752245903,
-0.005653727799654007,
-0.033492133021354675,
0.038191620260477066,
-0.035014502704143524,
-0.020165881142020226,
-0.018478037789463997,
-0.01331521850079298,
-0.0038114399649202824,
-0.008339937776327133,
-0.0030888658948242664,
-0.03474974259734154,
0.02429172396659851,
0.032344840466976166,
0.0040568942204117775,
0.00044988503213971853,
0.009945045225322247,
0.011517057195305824,
-0.043266184628009796,
-0.028836769983172417,
0.06468968093395233,
0.015631867572665215,
-0.05723227187991142,
0.016933605074882507,
0.01821327768266201,
-0.0005574437673203647,
-0.0032598567195236683,
0.0033591417595744133,
0.026520119979977608,
0.025725839659571648,
-0.003935546148568392,
0.02389458380639553,
0.015918690711259842,
-0.00503319688141346,
0.02272522822022438,
-0.0162496417760849,
-0.043950147926807404,
-0.010226352140307426,
0.034264348447322845,
-0.02852788381278515,
0.004842900671064854,
-0.0133262500166893,
0.051407553255558014,
0.00861572939902544,
0.0012445095926523209,
-0.033094990998506546,
-0.002436618786305189,
0.0068672108463943005,
0.004685699474066496,
-0.013249028474092484,
0.012664350681006908,
0.01057936530560255,
-0.02167722024023533,
0.023409191519021988,
-0.010822062380611897,
-0.009194891899824142,
-0.013955054804682732,
0.010788967832922935,
-0.015620836056768894,
0.019073747098445892,
-0.021235954016447067,
-0.024755053222179413,
0.040133193135261536,
-0.01308355387300253,
-0.021975073963403702,
0.04827456176280975,
0.025218384340405464,
0.000178057947778143,
0.006801020819693804,
0.034573234617710114,
0.020684370771050453,
0.007661490701138973,
-0.03093278594315052,
0.026674563065171242,
0.026475993916392326,
-0.04077303037047386,
0.029101530089974403,
0.005962614435702562,
-0.02698344923555851,
-0.04196444898843765,
-0.018522163853049278,
-0.008610214106738567,
-0.003039223374798894,
0.005775075871497393,
-0.01919509470462799,
0.007556689903140068,
0.003692849539220333,
0.01544432993978262,
0.057276397943496704,
0.005325535777956247,
-0.024357914924621582,
0.02120285853743553,
-0.012432685121893883,
-0.010860673151910305,
0.015212664380669594,
-0.005703370086848736,
-0.005935035180300474,
-0.012201020494103432,
-0.03911827877163887,
-0.015168538317084312,
0.004765678662806749,
0.034220222383737564,
-0.03201388940215111,
-0.021622061729431152,
0.031109292060136795,
-0.004208579659461975,
-0.017992643639445305,
-0.016470273956656456,
0.006492134183645248,
-0.011340550146996975,
-0.009525842033326626,
-0.0003778344835154712,
-0.04152318462729454,
-0.021622061729431152,
0.002334575867280364,
-0.01998937502503395,
0.03245515376329422,
0.02815280668437481,
0.027226146310567856,
0.01984596438705921,
-0.014738302677869797,
0.0014920325484126806,
0.033889271318912506,
-0.005215219222009182,
-0.06411603093147278,
0.0059460666961967945,
-0.03410990536212921,
0.0034777321852743626,
-0.018202245235443115,
-0.0016037281602621078,
-0.006729315035045147,
-0.022570785135030746,
0.000026932773835142143,
-0.016569558531045914,
-0.003946577664464712,
0.013602041639387608,
-0.008455770090222359,
-0.007694585714489222,
0.004721552133560181,
0.008257200941443443,
-0.018996525555849075,
-0.0035687433555722237,
0.020000407472252846,
-0.006332175340503454,
-0.011914197355508804,
-0.023673951625823975,
-0.05131930112838745,
0.026718690991401672,
-0.016966698691248894,
0.007093359716236591,
0.007793870754539967,
0.043972212821245193,
0.025615524500608444,
-0.010005719028413296,
0.043729517608881,
0.01984596438705921,
0.017010826617479324,
-0.03993462398648262,
-0.02354157157242298,
-0.003753523575142026,
-0.005741981323808432,
0.026829006150364876,
0.010463532991707325,
0.017904391512274742,
0.014054340310394764,
0.032278649508953094,
-0.02541695348918438,
-0.009288661181926727,
-0.033845145255327225,
-0.007214708253741264,
-0.011020632460713387,
0.016128292307257652,
-0.04181000590324402,
-0.01049662847071886,
-0.018467005342245102,
0.012609192170202732,
0.016712971031665802,
0.04216301813721657,
0.0018064349424093962,
0.02588028460741043,
0.0005826097331009805,
-0.01445147953927517,
-0.00969131663441658,
0.016382021829485893,
0.010474564507603645,
-0.0027344736736267805,
0.027512969449162483,
-0.007992440834641457,
0.03841225430369377,
-0.014583859592676163,
0.012995299883186817,
-0.012465780600905418,
-0.011290907859802246,
-0.0001764204353094101,
-0.010601429268717766,
-0.0176506619900465,
-0.005753012839704752,
0.002141521777957678,
-0.006977527402341366,
-0.017705820500850677,
0.0533050000667572,
-0.01898549310863018,
-0.011781817302107811,
-0.00537242041900754,
-0.04105985164642334,
-0.012322369031608105,
0.00819652620702982,
0.029035339131951332,
0.016315830871462822,
-0.009321755729615688,
-0.008637792430818081,
0.012840856797993183,
-0.014197751879692078,
0.027865983545780182,
0.006778957322239876,
-0.009972624480724335,
-0.02579203061759472,
0.0016299283597618341,
-0.047612663358449936,
-0.03651480749249458,
0.0027496423572301865,
0.007970376871526241,
-0.024843307211995125,
0.009796117432415485,
-0.007264350540935993,
0.006607966497540474,
0.02265903726220131,
-0.015885595232248306,
-0.037397339940071106,
0.05793830007314682,
-0.0013844738714396954,
-0.015885595232248306,
-0.010921346955001354,
0.01230030506849289,
0.02623329684138298,
-0.01802573911845684,
-0.01527885440737009,
-0.0205740537494421,
0.015554646030068398,
0.02132420614361763,
-0.0068672108463943005,
0.02136833220720291,
0.04492093622684479,
0.017683757469058037,
0.009090091101825237,
0.0008342695655301213,
-0.012013481929898262,
0.03497037664055824,
-0.013370377011597157,
0.004445760510861874,
0.010540754534304142,
-0.01587456464767456,
-0.05012788251042366,
-0.016779160127043724,
0.003794892458245158,
0.0016602653777226806,
0.005579263903200626,
0.014065371826291084,
0.02235015109181404,
-0.012366495095193386,
0.004743615631014109,
0.006596934981644154,
0.00030457734828814864,
-0.005725433584302664,
0.006039835978299379,
-0.0017223185859620571,
-0.021224921569228172,
0.017727883532643318,
0.007512563373893499,
0.006916853133589029,
-0.0451195053756237,
0.029895808547735214,
0.025372827425599098,
-0.017551377415657043,
-0.00544688431546092,
-0.027601223438978195,
-0.011616341769695282,
-0.005736465100198984,
-0.025725839659571648,
-0.010342185385525227,
-0.029454542323946953,
-0.008444738574326038,
-0.012620223686099052,
-0.023365063592791557,
-0.006354238372296095,
-0.008786720223724842,
-0.011627374216914177,
0.015554646030068398,
-0.02852788381278515,
0.006685188505798578,
0.027512969449162483,
-0.016911540180444717,
-0.015554646030068398,
0.04884820803999901,
0.006409396883100271,
0.027159957215189934,
-0.03567640110850334,
-0.0041782427579164505,
-0.016073133796453476,
0.006618998479098082,
0.006392849143594503,
-0.004961491096764803,
-0.05780591815710068,
-0.037397339940071106,
0.046377114951610565,
0.012267210520803928,
-0.003235035575926304,
0.013447598554193974,
0.02050786279141903,
0.014109497889876366,
-0.01524575985968113,
-0.008621245622634888,
0.009255565702915192,
-0.027292337268590927,
-0.0026393255684524775,
-0.02508600428700447,
0.01891930401325226,
-0.024093154817819595,
0.020441673696041107,
-0.018180182203650475,
-0.008025535382330418,
-0.008748109452426434,
-0.01786026358604431,
0.008808783255517483,
-0.0168343186378479,
0.009194891899824142,
0.005764044355601072,
0.02546107955276966,
-0.021975073963403702,
0.024071089923381805,
-0.0010376658756285906,
0.02235015109181404,
0.025196321308612823,
0.03362451121211052,
-0.02382839471101761,
0.010518691502511501,
0.021853726357221603,
0.023960774764418602,
-0.008119304664433002,
0.02894708700478077,
0.025703776627779007,
-0.005002859514206648,
-0.0071209389716386795,
0.0016382021130993962,
0.027910109609365463,
-0.024490293115377426,
-0.01097650546580553,
-0.03397752344608307,
-0.024732990190386772,
-0.004084473475813866,
-0.04346475750207901,
0.030469456687569618,
0.03803717717528343,
0.005918487906455994,
0.0016395810525864363,
0.0072202240116894245,
-0.037044327706098557,
0.007644942961633205,
-0.00022925176017452031,
-0.016701938584446907,
0.03289642184972763,
-0.025152193382382393,
-0.032764043658971786,
-0.008985290303826332,
0.020518895238637924,
0.005350356921553612,
0.007231255527585745,
0.021258017048239708,
0.005962614435702562,
-0.011881101876497269,
-0.010617977008223534,
0.0205740537494421,
0.013833706267178059,
-0.019581204280257225,
-0.014440448023378849,
0.029167719185352325,
0.007854544557631016,
0.006277016829699278,
0.021622061729431152,
0.013568947091698647,
-0.01122471783310175,
0.009189375676214695,
-0.008450254797935486,
-0.007087843958288431,
-0.02270316518843174,
-0.02704964019358158,
0.11190520226955414,
-0.021611029282212257,
0.01392196025699377,
0.02784392051398754,
0.009189375676214695,
-0.011848007328808308,
0.019437791779637337,
0.0014203267637640238,
0.0015720120863988996,
-0.007644942961633205,
0.020143818110227585,
-0.004434728994965553,
0.024446167051792145,
0.02148968167603016,
0.008306843228638172,
-0.009790602140128613,
-0.014374257996678352,
0.04765678942203522,
-0.008555055595934391,
-0.013535851612687111,
-0.003301225369796157,
0.020044533535838127,
0.0003874872054439038,
0.04809805378317833,
0.004128600470721722,
-0.0007873850408941507,
-0.013282123021781445,
-0.01896343007683754,
-0.00752911064773798,
-0.012366495095193386,
-0.025240447372198105,
0.003965883050113916,
0.020077629014849663,
-0.02702757716178894,
0.021809600293636322,
-0.03715464472770691,
-0.005741981323808432,
-0.03124167211353779,
-0.0002520045673009008,
0.011439835652709007,
0.036227986216545105,
0.0006032941164448857,
0.026674563065171242,
0.0013968844432383776,
0.013359345495700836,
0.028660263866186142,
-0.0196363627910614,
0.0012203778605908155,
0.006288048345595598,
-0.021544840186834335,
0.014616955071687698,
0.0009473441168665886,
0.02429172396659851,
-0.010469049215316772,
-0.021809600293636322,
0.0050138914957642555,
-0.005598569288849831,
-0.013039426878094673,
0.007562205661088228,
-0.03947129473090172,
-0.0008466801955364645,
0.011649437248706818,
0.029432479292154312,
0.002236669883131981,
0.00990091823041439
] | 2024-07-05 | 55 | 38964783 | [
"T cells",
"human T cells",
"tumor cells",
"Engineered cells",
"cancer cells",
"control cells",
"human tumors",
"T-cell metabolic engineering",
"T-cell activation markers",
"T-cell antitumor function",
"metabolite transporters",
"T-cell receptors",
"superior glycolytic capacity",
"available essential metabolites",
"Glucose transporter",
"vivo therapeutic potential",
"tumor-specific chimeric antigen",
"numerous hurdles",
"cellular immunotherapies",
"the tumor microenvironment",
"the tumor vicinity",
"cancer",
"conjunction",
"Glucose",
"phosphofructokinase",
"upregulation",
"a high metabolic rate",
"their glycolytic capacity",
"a glucose transporter",
"a key glycolysis enzyme"
] | [
"Immunotherapy",
"Receptors, Antigen",
"T-Lymphocytes"
] | 0 | 10.1136/jitc-2023-008434
10.1038/s41591-022-02084-8
10.1038/s41591-022-01765-8
10.1126/science.aar4060
10.1016/j.addr.2019.01.007
10.1038/s41586-023-06243-w
10.3324/haematol.2021.280169
10.1007/978-3-030-91311-3_9
10.20900/immunometab20200020
10.3324/haematol.2022.281628
10.1038/s42255-020-00317-z
10.1016/j.celrep.2018.01.040
10.1016/j.cmet.2016.10.018
10.1016/j.cell.2015.08.012
10.1038/s41577-019-0203-y
10.1126/science.1222278
10.1042/bj2450313
10.4049/jimmunol.1103020
10.1016/j.addr.2019.01.007
10.1186/1479-5876-10-29
10.3389/fimmu.2021.779787
10.1158/0008-5472.CAN-06-3986
10.1186/s40425-019-0721-y
10.3390/cancers13164184
10.1021/bi00157a032
10.7554/eLife.55185
10.7554/eLife.44235
10.1016/j.cireng.2019.12.011
10.3389/fimmu.2019.01683
10.1016/j.immuni.2021.12.012
10.1038/s41586-021-03442-1
10.3389/fimmu.2021.689337
10.3389/fnut.2023.1113739
10.1136/jitc-2022-006287
10.1038/s41467-022-32521-8
10.3389/fimmu.2023.1101433
10.26508/lsa.202000858
10.1007/s13402-020-00508-6
10.1016/j.immuni.2021.04.008
10.1126/sciadv.adc9657
10.1016/j.cmet.2022.02.015
10.3389/fimmu.2022.976628
10.3389/fimmu.2021.669456
10.1038/ncomms7692
10.1084/jem.20130252
10.1126/science.1129003
10.3389/fonc.2020.00851
10.3389/fimmu.2022.880959
10.1172/JCI148546
10.1126/sciimmunol.aap9520
10.1016/j.immuni.2016.07.009
10.1016/j.xcrm.2021.100227
10.1182/blood.2019004500 | [
"Toledano Zur",
"Atar",
"Barliya",
"Hoogi",
"Abramovich",
"Gottlieb",
"Ron-Harel",
"Cohen"
] | [
"Bar-Ilan University, Ramat Gan, Israel.",
"Technion Israel Institute of Technology, Haifa, Haifa, Israel.",
"Bar-Ilan University, Ramat Gan, Israel.",
"Bar-Ilan University, Ramat Gan, Israel.",
"Technion Israel Institute of Technology, Haifa, Haifa, Israel.",
"Technion Israel Institute of Technology, Haifa, Haifa, Israel.",
"Technion Israel Institute of Technology, Haifa, Haifa, Israel.",
"Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Tel Aviv, Israel [email protected]."
] | [
"38964783",
"36471036",
"35440724",
"29567705",
"30653988",
"37495877",
"35354252",
"35165867",
"32642279",
"36200421",
"33398194",
"29425506",
"27829134",
"26321681",
"31406325",
"22923583",
"4237582",
"2822019",
"22544927",
"9670966",
"30653988",
"22330761",
"34899740",
"17440104",
"31500665",
"34439338",
"1420159",
"32367803",
"30990168",
"31409447",
"31379871",
"35021054",
"33828302",
"34248978",
"36875841",
"37399358",
"36068198",
"36923405",
"33536238",
"32219704",
"33979589",
"36449620",
"35316657",
"36203587",
"34163475",
"25809635",
"24043759",
"16946036",
"32509589",
"36505421",
"34981777",
"30683669",
"27496732",
"33948568",
"32573723"
] | [] | 10.369607 | 4.880852 |
38963989 | 763 | Multiple myeloma and infections in the era of novel treatment modalities. | Infections are major cause of morbidity and mortality in patients with multiple myeloma. Current treatment landscape of newly-diagnosed multiple myeloma includes different classes of drugs, such as proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies, all of which are characterized by specific risk and pattern of infectious complications. Additionally, autologous and allogeneic hematopoietic cell transplantation, widely used in the treatment of multiple myeloma, are complex procedures, carrying a significant risk of complications, and mainly infections. Finally, novel treatment modalities such as bispecific T-cell engagers and chimeric antigen receptor T-lymphocytes have been changing the paradigm of myeloma treatment in relapsed-refractory setting. These agents due to unique mechanism of action carry distinct pattern of infectious complications. In this review, an attempt has been made to summarize the incidence, risk factors, and patterns of infections during different stages of myeloma treatment including novel treatment modalities, and to provide evidence underlying the current concept of infectious disease prophylaxis in this category of patients. | [
0.004820241592824459,
0.014884688891470432,
0.07798799127340317,
0.033247511833906174,
-0.04770013689994812,
0.011255331337451935,
0.02698254957795143,
0.030158238485455513,
-0.018006369471549988,
0.019324172288179398,
0.018697675317525864,
-0.04497811943292618,
-0.02566474676132202,
0.04227770119905472,
0.006389182526618242,
-0.07690782845020294,
0.015705615282058716,
0.04253694415092468,
-0.01476587075740099,
0.05750804394483566,
0.013836927711963654,
0.030374271795153618,
0.02605360746383667,
-0.022316232323646545,
-0.014787474647164345,
-0.006643021944910288,
-0.04981726035475731,
0.017801137641072273,
-0.012929588556289673,
0.03134642168879509,
-0.012292291037738323,
-0.025448713451623917,
-0.00259644933976233,
0.006324372719973326,
-0.014182581566274166,
-0.004790536593645811,
0.005076780915260315,
-0.00099645322188735,
-0.006637620739638805,
0.033830802887678146,
0.007647576276212931,
0.003969610668718815,
-0.012508323416113853,
0.06614937633275986,
-0.06627899408340454,
0.03309629112482071,
-0.014668656513094902,
-0.08727741986513138,
0.043897952884435654,
-0.016094475984573364,
-0.019496997818350792,
-0.006778042297810316,
-0.005984120536595583,
0.00862512644380331,
-0.028473179787397385,
0.011104107834398746,
-0.015500384382903576,
0.012594737112522125,
-0.030374271795153618,
-0.027911493554711342,
0.012983596883714199,
-0.021894967183470726,
0.004126234445720911,
-0.03130321577191353,
-0.028775624930858612,
-0.013815324753522873,
-0.044286809861660004,
-0.019648222252726555,
-0.008932974189519882,
-0.03944766893982887,
0.007717786822468042,
-0.06528524309396744,
0.016580550000071526,
0.04098150134086609,
-0.007885213010013103,
0.00792841985821724,
-0.035429447889328,
-0.00386429438367486,
-0.030763130635023117,
-0.03342033922672272,
0.01891370862722397,
-0.0003858218260575086,
0.019237758591771126,
-0.014020556584000587,
-0.008970779366791248,
0.09652364253997803,
0.018308816477656364,
0.0005316442693583667,
-0.04597187042236328,
-0.016116078943014145,
-0.006529604084789753,
0.010212970897555351,
-0.03750336915254593,
0.042969007045030594,
-0.02158171869814396,
-0.010672041215002537,
0.06442110985517502,
-0.02029632218182087,
-0.008911370299756527,
0.06537165492773056,
0.01300519984215498,
0.02605360746383667,
-0.01174140628427267,
-0.006016525439918041,
0.03724412992596626,
-0.03307468816637993,
-0.0050794812850654125,
-0.04463246464729309,
0.015759624540805817,
-0.007977026514708996,
0.07314885407686234,
-0.03357156366109848,
-0.026658499613404274,
0.025038251653313637,
-0.02650727704167366,
-0.007604369428008795,
-0.005843698978424072,
-0.0035456453915685415,
0.028149129822850227,
0.0027949297800660133,
-0.024109307676553726,
0.02605360746383667,
-0.020155899226665497,
-0.027198582887649536,
0.0003169612609781325,
-0.04117593169212341,
0.05128628760576248,
-0.04234251379966736,
-0.023677241057157516,
-0.08075322210788727,
0.032901860773563385,
-0.04026859253644943,
0.020123494789004326,
0.0022494459990411997,
-0.003788682632148266,
0.03800024464726448,
0.005924711469560862,
0.012778365053236485,
-0.01677498035132885,
-0.009354238398373127,
-0.013653299771249294,
0.019551007077097893,
-0.014949499629437923,
0.0327722392976284,
0.00048168658395297825,
-0.05029253661632538,
0.010672041215002537,
0.009980735369026661,
0.04383314028382301,
0.009969932958483696,
-0.04726807028055191,
0.05202079936861992,
-0.004320664331316948,
0.05461319908499718,
-0.02028552070260048,
-0.05690315365791321,
-0.021290075033903122,
0.04549659788608551,
0.011622587218880653,
-0.031994521617889404,
-0.003659062786027789,
0.015716416761279106,
0.010137359611690044,
-0.0318865031003952,
-0.0004010116681456566,
0.023612432181835175,
-0.00924082100391388,
0.03186490014195442,
-0.015586797147989273,
0.022143404930830002,
0.03711450845003128,
-0.021862562745809555,
-0.04804578796029091,
-0.04644714295864105,
-0.03914522007107735,
-0.00971069373190403,
-0.0066646249033510685,
-0.010002338327467442,
-0.03612075373530388,
-0.013566887006163597,
-0.04679279774427414,
0.013836927711963654,
0.0380866564810276,
0.013944944366812706,
-0.035515863448381424,
0.0016567048151046038,
-0.017509492114186287,
0.03141123056411743,
-0.024174118414521217,
-0.011514570564031601,
0.006259562913328409,
0.010131957940757275,
-0.002653158036991954,
0.01723945140838623,
0.003105477662757039,
0.006961670704185963,
-0.024001291021704674,
0.02516787126660347,
-0.026852929964661598,
-0.03849712014198303,
0.0360991507768631,
-0.04337947070598602,
-0.023309985175728798,
-0.01631050929427147,
-0.01903252676129341,
-0.005449438001960516,
0.0015068317297846079,
0.017358269542455673,
0.031605660915374756,
0.04111112281680107,
0.008765548467636108,
0.00022160283697303385,
0.02204619161784649,
0.03389561176300049,
0.008922172710299492,
-0.004434082191437483,
-0.019259361550211906,
0.01635371521115303,
-0.01106090098619461,
0.020199107006192207,
0.054440371692180634,
-0.002430373802781105,
0.005789690650999546,
0.04117593169212341,
-0.005219902843236923,
-0.004093829542398453,
0.0047473302111029625,
-0.019713031128048897,
0.018416833132505417,
0.020015478134155273,
0.02033952809870243,
-0.024066101759672165,
-0.0007831204566173255,
-0.03812986612319946,
-0.03164886683225632,
-0.014971102587878704,
-0.0071074930019676685,
0.01149296760559082,
0.023936482146382332,
0.009840313345193863,
0.015543590299785137,
0.04908274859189987,
0.010812463238835335,
0.008781750686466694,
-0.035991135984659195,
-0.012767563574016094,
0.010212970897555351,
-0.024476565420627594,
0.0006430363864637911,
0.024109307676553726,
-0.05945234373211861,
0.01411777175962925,
0.01896771788597107,
-0.01944299042224884,
0.021095644682645798,
-0.027241790667176247,
-0.012249084189534187,
-0.023979688063263893,
-0.040808677673339844,
0.014366209506988525,
0.012087059207260609,
0.020620372146368027,
-0.007404538802802563,
-0.0035969531163573265,
-0.027630649507045746,
-0.0031918908935040236,
-0.02080399915575981,
-0.017023418098688126,
0.05435395985841751,
-0.01129853818565607,
0.018200799822807312,
0.008166056126356125,
0.031000768765807152,
-0.03849712014198303,
-0.041716016829013824,
-0.0065134018659591675,
0.013188828714191914,
0.047440897673368454,
-0.01193583570420742,
-0.02696094661951065,
0.03622877225279808,
-0.01678578183054924,
0.02732820250093937,
-0.013977349735796452,
0.004852646496146917,
0.007031881716102362,
0.018211601302027702,
-0.005741083063185215,
-0.039555683732032776,
-0.014171780087053776,
-0.039037205278873444,
0.04279618337750435,
-0.01193583570420742,
-0.025016646832227707,
0.0008351034484803677,
0.01719624549150467,
-0.0030811738688498735,
-0.02339639887213707,
-0.006589013617485762,
0.06848253309726715,
-0.029920602217316628,
0.01299439836293459,
-0.027717063203454018,
-0.013383258134126663,
-0.006162347737699747,
0.03499738126993179,
-0.0159432515501976,
-0.05703277140855789,
0.0027922294102609158,
0.017001815140247345,
0.0006643021479249001,
-0.04016057774424553,
0.032945066690444946,
0.0554773323237896,
-0.00429636100307107,
0.017315063625574112,
-0.006545806769281626,
-0.03318270295858383,
0.020663578063249588,
-0.025880780071020126,
-0.04061424732208252,
-0.0008432046743109822,
-0.00232505751773715,
0.0022521463688462973,
-0.011255331337451935,
-0.05560695379972458,
-0.008641328662633896,
0.004093829542398453,
-0.02163572795689106,
-0.052798520773649216,
0.03208093345165253,
-0.012681150808930397,
0.03441409394145012,
-0.016569748520851135,
0.009624280035495758,
-0.015727218240499496,
0.02124686725437641,
-0.01852484978735447,
0.006929265800863504,
-0.018373625352978706,
-0.03361476957798004,
0.020609570667147636,
0.0054737417958676815,
0.03326911851763725,
0.026831327006220818,
-0.06308170408010483,
-0.020091090351343155,
0.023590829223394394,
-0.043530695140361786,
0.024195721372961998,
0.017714723944664,
-0.017574302852153778,
0.034694936126470566,
0.03043908253312111,
-0.003953407984226942,
0.025772763416171074,
-0.008328081108629704,
0.019713031128048897,
0.006572810932993889,
-0.03320430591702461,
-0.012670348398387432,
0.012324695475399494,
-0.014809077605605125,
0.06394583731889725,
0.02741461619734764,
0.06649502366781235,
0.021290075033903122,
-0.02289952151477337,
-0.04739769175648689,
0.005417033098638058,
0.004409778397530317,
0.026680102571845055,
-0.017779534682631493,
-0.02518947422504425,
-0.03180009126663208,
0.06446431577205658,
-0.04601507633924484,
0.007723188027739525,
-0.006761840078979731,
0.006243360228836536,
0.05737842619419098,
-0.0012010097270831466,
0.0003578050236683339,
-0.009861917234957218,
-0.016062069684267044,
0.04361710697412491,
-0.03579670563340187,
0.00798782892525196,
-0.04376833140850067,
0.03234017267823219,
-0.021063240244984627,
-0.005703276954591274,
-0.012346298433840275,
0.027090566232800484,
-0.03357156366109848,
0.031238405033946037,
-0.06191512197256088,
0.06900101155042648,
0.026377657428383827,
-0.016072871163487434,
0.028624402359128,
-0.02077159471809864,
-0.027068963274359703,
-0.01988585852086544,
-0.026356054469943047,
-0.0388643778860569,
0.03326911851763725,
-0.04316343739628792,
0.030611908063292503,
-0.004091129172593355,
0.0013225284637883306,
0.02208939753472805,
0.029402121901512146,
-0.0029920602682977915,
0.017768733203411102,
-0.038605138659477234,
-0.02300753816962242,
0.025902383029460907,
-0.001287422957830131,
0.019529404118657112,
0.04493490979075432,
-0.05197759345173836,
0.007053484674543142,
-0.0042207492515444756,
-0.009446052834391594,
-0.032448191195726395,
0.06234718859195709,
0.020922817289829254,
-0.0019064932130277157,
-0.04718165844678879,
-0.058933865278959274,
0.07349450141191483,
-0.04536697641015053,
0.003715771483257413,
0.039102014154195786,
0.03279384225606918,
-0.020404338836669922,
-0.028948452323675156,
-0.0016094475286081433,
0.006923865061253309,
-0.013966548256576061,
0.035515863448381424,
-0.04286099225282669,
-0.002946153050288558,
0.05085422098636627,
0.018762486055493355,
0.000377720600226894,
0.04908274859189987,
0.014106969349086285,
0.001246241619810462,
-0.005984120536595583,
-0.048348236829042435,
0.009105800651013851,
-0.007226311601698399,
-0.02871081605553627,
-0.028797229751944542,
0.010655838996171951,
-0.07997550070285797,
-0.021344082430005074,
0.00628116587176919,
0.024973440915346146,
-0.012897183187305927,
0.010909677483141422,
-0.04378993436694145,
0.014636251144111156,
0.03270743042230606,
-0.013556084595620632,
-0.05919310450553894,
-0.02121446281671524,
-0.033809199929237366,
0.055347710847854614,
-0.05111346021294594,
-0.012173471972346306,
0.01588924415409565,
0.0016026964876800776,
0.025880780071020126,
-0.03126000612974167,
0.012929588556289673,
0.04821861535310745,
0.010893475264310837,
-0.005444037262350321,
0.03175688534975052,
-0.01903252676129341,
-0.02253226563334465,
0.002246745629236102,
-0.006486397702246904,
-0.04713844880461693,
0.05750804394483566,
-0.03486776351928711,
0.03329072147607803,
-0.014236589893698692,
-0.013037605211138725,
0.041651204228401184,
-0.007220910396426916,
0.015738019719719887,
-0.04623110964894295,
-0.01991826295852661,
-0.060316476970911026,
-0.023720448836684227,
0.001749869086779654,
-0.014949499629437923,
-0.0025221880059689283,
0.011860224418342113,
0.02244585193693638,
0.003094675950706005,
0.031000768765807152,
-0.011546975933015347,
0.0057572852820158005,
-0.0042072469368577,
0.030352668836712837,
-0.03519181162118912,
-0.02348281256854534,
0.038626741617918015,
0.026399260386824608,
-0.0039048006292432547,
-0.008468502201139927,
-0.008376688696444035,
-0.030719924718141556,
-0.01583523489534855,
0.0014973803190514445,
-0.004925557412207127,
-0.0043314662761986256,
-0.008112047798931599,
-0.02257547155022621,
0.048780303448438644,
-0.009624280035495758,
-0.019961470738053322,
0.03350675478577614,
0.014506631530821323,
-0.0071777040138840675,
-0.004390875343233347,
0.011125710792839527,
0.029445329681038857,
0.00023004163813311607,
-0.008706139400601387,
0.008203862234950066,
-0.035559069365262985,
-0.011460562236607075,
-0.03439249098300934,
-0.0038669947534799576,
0.007863609120249748,
-0.02204619161784649,
0.004720326047390699,
0.010920479893684387,
0.00012236257316544652,
0.03182169422507286,
0.02376365475356579,
-0.03914522007107735,
-0.005333320237696171,
0.014106969349086285,
0.03977171704173088,
-0.0006973822601139545,
0.012475918978452682,
0.02430373802781105,
0.019280966371297836,
0.018298014998435974,
-0.004741929471492767,
-0.019648222252726555,
-0.019237758591771126,
0.009986136108636856,
-0.025837574154138565,
-0.026312846690416336,
-0.04184563457965851,
-0.009635081514716148,
-0.009467655792832375,
-0.015565194189548492,
-0.008484705351293087,
-0.013566887006163597,
-0.03884277492761612,
0.020847206935286522,
0.004493491258472204,
0.007679981179535389,
-0.0022778003476560116,
-0.02782507985830307,
-0.016591351479291916,
-0.018676072359085083,
-0.003815686795860529,
0.010547822341322899,
0.025815971195697784,
-0.035602275282144547,
-0.004401676822453737,
-0.03983652591705322,
-0.022381043061614037,
0.03087114728987217,
0.0022318933624774218,
0.009851114824414253,
-0.015792028978466988,
-0.008187659084796906,
-0.01191423274576664,
0.002956954762339592,
0.021009230986237526,
0.005730281118303537,
0.03313949704170227,
-0.026356054469943047,
-0.008095845580101013,
0.03411164507269859,
0.0024668294936418533,
-0.0020644674077630043,
-0.001151727163232863,
0.02257547155022621,
-0.029294105246663094,
-0.008274072781205177,
-0.02648567408323288,
-0.03944766893982887,
-0.00004582267138175666,
0.08230865746736526,
0.016958607360720634,
-0.02036113105714321,
0.002523538190871477,
0.02259707637131214,
0.021398091688752174,
0.024044498801231384,
-0.0034295273944735527,
-0.011082504875957966,
0.028127526864409447,
-0.010094152763485909,
-0.007631373591721058,
-0.02510306052863598,
0.0012354400241747499,
-0.0006653148448094726,
-0.018676072359085083,
0.03873475641012192,
0.02743621915578842,
0.001137549988925457,
0.054958853870630264,
-0.03804345056414604,
-0.03048228845000267,
-0.0032458992209285498,
0.015295152552425861,
-0.0018119786400347948,
-0.0073505304753780365,
-0.023720448836684227,
0.011438959278166294,
0.009284027852118015,
0.04653355851769447,
0.0009424449526704848,
0.03281544893980026,
0.0012307142606005073,
0.006551207508891821,
-0.020825602114200592,
0.019756238907575607,
0.005444037262350321,
-0.00716690206900239,
-0.01721784844994545,
0.007896014489233494,
-0.03564548119902611,
0.015435573644936085,
0.004101931117475033,
0.022618679329752922,
-0.018265608698129654,
0.0054521383717656136,
-0.013350853696465492,
0.012961993925273418,
-0.028624402359128,
0.006529604084789753,
-0.012421910651028156,
-0.010672041215002537,
0.012616340070962906,
0.030806338414549828,
0.03234017267823219,
-0.016558947041630745,
0.0075935679487884045,
0.014171780087053776,
-0.009219218045473099,
-0.009791705757379532,
0.004720326047390699,
0.008068840950727463,
-0.0009032889502122998,
-0.003615856170654297,
0.003067671786993742,
0.058933865278959274,
0.010456007905304432,
-0.016483334824442863,
0.017315063625574112,
-0.0009255673503503203,
0.0012799968244507909,
0.006864455994218588,
-0.021732943132519722,
-0.038648344576358795,
0.037287335842847824,
0.016450930386781693,
-0.0010781408054754138,
-0.061612676829099655,
-0.05880424380302429,
-0.008490106090903282,
-0.008598122745752335,
0.04549659788608551,
-0.023720448836684227,
0.014431019313633442,
-0.017131434753537178,
0.04476208612322807,
-0.03404683619737625,
0.006535005290061235,
-0.007269517984241247,
0.014042159542441368,
-0.030331065878272057,
-0.02821393869817257,
-0.043077025562524796,
-0.005784289445728064,
0.016429327428340912,
0.05266889929771423,
0.0010342590976506472,
0.04718165844678879,
-0.010299383662641048,
0.01900012232363224,
-0.006453992798924446,
0.0033026079181581736,
0.003521341597661376,
0.012659546919167042,
-0.004350369330495596,
-0.00796082429587841,
-0.0071777040138840675,
-0.0006015175022184849,
-0.012929588556289673,
-0.019345775246620178,
0.01991826295852661,
-0.023309985175728798,
0.017099030315876007,
0.007345129735767841,
0.028797229751944542,
0.03227536380290985,
0.0047257267870008945,
-0.02079319767653942,
-0.0019199952948838472,
0.043509092181921005,
0.053576238453388214,
-0.06372980028390884,
0.05068139359354973,
-0.013966548256576061,
-0.032923463732004166,
-0.0038129864260554314,
-0.009640483185648918,
-0.012054653838276863,
-0.029942205175757408,
0.028537988662719727,
0.002668010303750634,
0.0035645482130348682,
-0.01761750876903534,
-0.02200298383831978,
-0.011266132816672325,
0.039123617112636566,
-0.033312324434518814,
-0.03946927189826965,
0.005128088872879744,
0.003880496835336089,
0.014938697218894958,
0.01947539485991001,
0.002921849489212036,
0.008441498503088951,
0.02423892728984356,
-0.023180365562438965,
0.005319818388670683,
-0.02518947422504425,
-0.023223571479320526,
0.012076257728040218,
-0.04158639535307884,
0.0002475943183526397,
0.012529927305877209,
-0.020101891830563545,
-0.027587443590164185,
-0.023288382217288017,
0.054569993168115616,
0.007550361100584269,
0.0035537465009838343,
-0.010888074524700642,
-0.007339728996157646,
0.01632131077349186,
0.0317784883081913,
0.0019226956646889448,
0.03238338232040405,
-0.007636774331331253,
-0.01761750876903534,
0.05374906584620476,
-0.022273026406764984,
0.028429972007870674,
0.01082866545766592,
-0.032858654856681824,
-0.020944422110915184,
0.013566887006163597,
-0.045669425278902054,
0.0031081780325621367,
-0.006102938670665026,
0.0021454798988997936,
0.006556608248502016,
-0.015165532939136028,
0.07669179886579514,
-0.020080288872122765,
-0.012616340070962906,
-0.006535005290061235,
0.01279996894299984,
-0.0040614246390759945,
-0.01588924415409565,
-0.009084196761250496,
-0.014992705546319485,
-0.00901938695460558,
0.008317279629409313,
0.03428447246551514,
-0.07202547788619995,
-0.026269640773534775,
-0.03352835774421692,
0.028948452323675156,
-0.014906292781233788,
0.016558947041630745,
-0.0017917255172505975,
-0.007339728996157646,
0.004542098380625248,
-0.03182169422507286,
-0.006351376883685589,
-0.012929588556289673,
0.01720704697072506,
0.008932974189519882,
0.005681673996150494,
0.0026099514216184616,
-0.0168289877474308,
-0.011687397956848145,
-0.0036347589921206236,
0.021732943132519722,
0.0011497018858790398,
-0.007058885879814625,
-0.03223215788602829,
0.04463246464729309,
-0.011276934295892715,
-0.01100149191915989,
0.00012759462697431445,
-0.021981380879878998,
-0.023158762603998184,
-0.00995373073965311,
-0.016904599964618683,
0.010483012534677982,
-0.007150699850171804,
0.014841482974588871,
0.028991658240556717,
-0.004409778397530317,
0.02652888000011444,
0.010969087481498718,
-0.04206166788935661,
0.023936482146382332,
-0.01017516478896141,
0.037287335842847824,
0.02121446281671524,
0.02698254957795143,
-0.05504526570439339,
-0.017045021057128906,
-0.0025923987850546837,
-0.006367579568177462,
0.002811132464557886,
-0.03151924908161163,
-0.009883520193397999,
-0.01080706249922514,
-0.024411754682660103,
0.013458870351314545,
0.013037605211138725,
0.010283181443810463,
-0.061094194650650024,
0.039102014154195786,
-0.01901092380285263,
0.011125710792839527,
0.008565717376768589,
-0.003815686795860529,
0.028019510209560394,
-0.013307646848261356,
-0.008085043169558048,
0.0004972139722667634,
-0.00226429826579988,
0.03173528239130974,
-0.07777196168899536,
0.019108138978481293,
-0.01218427438288927,
-0.012659546919167042,
-0.05107025429606438,
0.0018565355567261577,
-0.010412801057100296,
-0.018211601302027702,
-0.029726171866059303,
-0.02300753816962242,
-0.025405507534742355,
0.003189190523698926,
-0.002763875061646104,
-0.006108339410275221,
-0.028581196442246437,
0.004855346865952015,
-0.024584582075476646,
-0.0138693330809474,
0.024865424260497093,
-0.015241144225001335,
0.020555561408400536,
0.0019456492736935616,
-0.0012097860453650355,
-0.031562454998493195,
0.027997905388474464,
0.028602799400687218,
0.021765347570180893,
-0.012670348398387432,
-0.0468360036611557,
0.0049201566725969315,
0.011719802394509315,
-0.007588167209178209,
0.02161412499845028,
-0.023093951866030693,
0.021927371621131897,
-0.04545339196920395,
0.02907807193696499,
0.006913063116371632,
0.038669947534799576,
0.012335496954619884,
0.03195131570100784,
0.02566474676132202,
-0.008198460564017296,
-0.017109831795096397,
0.03227536380290985,
-0.01544637605547905,
0.008128250017762184,
-0.009840313345193863,
0.0005613488610833883,
-0.010045545175671577,
-0.0036995690315961838,
0.005633066408336163,
0.04536697641015053,
0.026788119226694107,
-0.01641852594912052,
-0.02436854876577854,
0.02830035239458084,
0.0003201679792255163,
0.011644191108644009,
0.04108951985836029,
0.016937004402279854,
0.01850324496626854,
0.0056546698324382305,
0.03363637253642082,
-0.012745960615575314,
-0.00109974411316216,
-0.04078707471489906,
0.018740883097052574,
-0.012173471972346306,
0.0002043876884272322,
0.039922941476106644,
0.006205554585903883,
0.021063240244984627,
-0.006108339410275221,
-0.008333481848239899,
0.016504937782883644,
0.04102471098303795,
-0.020933618769049644,
-0.0389723926782608,
0.02564314380288124,
0.009532466530799866,
0.002049615141004324,
0.01148216612637043,
-0.03439249098300934,
0.020998429507017136,
0.04156479239463806,
0.008317279629409313,
-0.0012219379423186183,
-0.002580246888101101,
-0.02873241901397705,
-0.0075719645246863365,
0.03931804746389389,
-0.010672041215002537,
0.058069732040166855,
-0.06269284337759018,
-0.05387868732213974,
-0.011017694137990475,
-0.011795414611697197,
0.009467655792832375,
0.0018983919871971011,
0.02333158813416958,
-0.004696022253483534,
0.019075734540820122,
-0.06684067845344543,
0.06403224915266037,
-0.029834188520908356,
-0.02127927355468273,
0.042644958943128586,
-0.03933965042233467,
-0.007631373591721058,
0.029769377782940865,
0.013318448327481747,
0.011817017570137978,
0.005392729304730892,
-0.00121046113781631,
-0.014085366390645504,
-0.008743944577872753,
-0.015079119242727757,
-0.02069598250091076,
-0.03227536380290985,
-0.019572610035538673,
0.002273749792948365,
0.0069076623767614365,
-0.031043974682688713,
0.030611908063292503,
0.05072460323572159,
0.029466932639479637,
-0.037222523242235184,
-0.03126000612974167,
0.032016124576330185,
0.003934504929929972,
-0.012519125826656818,
-0.026377657428383827,
0.0026545082218945026,
0.03929644450545311,
-0.00859272200614214,
-0.011190521530807018,
0.02432534098625183,
0.028991658240556717,
-0.028602799400687218,
-0.015640806406736374,
0.02114965207874775,
-0.02475740760564804,
0.03270743042230606,
0.013458870351314545,
0.005271210800856352,
-0.009381243027746677,
-0.007669179700314999,
-0.0336579754948616,
-0.007647576276212931,
-0.014268994331359863,
0.016029665246605873,
-0.009321833960711956,
-0.03240498527884483,
0.023223571479320526,
-0.011017694137990475,
0.043854743242263794,
0.028062716126441956,
0.001223288127221167,
0.01629970781505108,
-0.0010632885387167335,
-0.005492644850164652,
0.00044151791371405125,
0.019961470738053322,
0.02471420168876648,
0.015316755510866642,
-0.014236589893698692,
0.004925557412207127,
0.007447745651006699,
-0.019637420773506165,
0.02343960478901863,
-0.047959376126527786,
0.04067905619740486,
0.042169686406850815,
-0.006815848406404257,
-0.03145443648099899,
-0.021732943132519722,
-0.0006116440636105835,
0.031130388379096985,
-0.02730659954249859,
0.001705312286503613,
-0.03041747771203518,
0.00009156095620710403,
0.004606908652931452,
0.02385006844997406,
0.020501554012298584,
0.005225303582847118,
0.006680827587842941,
0.019777841866016388,
0.006275765132158995,
0.017552699893712997,
-0.024454960599541664,
-0.0020415140315890312,
0.00454749958589673,
-0.02555673010647297,
0.010882673785090446,
0.008630527183413506,
0.016602152958512306,
-0.01947539485991001,
-0.026312846690416336,
-0.01166579406708479,
-0.004309862852096558,
-0.012346298433840275,
-0.001649953774176538,
-0.04601507633924484,
0.002601850079372525,
-0.013210431672632694,
0.010320987552404404,
0.0006578887114301324,
0.0022318933624774218,
0.012735159136354923,
-0.021365685388445854,
0.011212124489247799,
-0.008981581777334213,
-0.023590829223394394,
-0.013523680157959461,
0.02559993788599968,
0.028559593483805656,
-0.020047882571816444,
-0.05301455408334732,
0.002258897526189685,
-0.013512878678739071,
0.0010828665690496564,
0.03452210873365402,
0.005257708486169577,
-0.020145097747445107,
-0.01717464067041874,
-0.03629358112812042,
-0.01855725422501564,
-0.03724412992596626,
0.0032404984813183546,
0.0021198259200900793,
-0.02030712366104126,
-0.0031000766903162003,
-0.003669864498078823,
0.00231425603851676,
-0.019345775246620178,
-0.00368876731954515,
-0.026852929964661598,
0.0029083474073559046,
0.01898932084441185,
-0.003464632900431752,
-0.011082504875957966,
0.026226432994008064,
0.019162146374583244,
-0.029790982604026794,
-0.0015203338116407394,
-0.03761138394474983,
-0.020080288872122765,
-0.0074207414872944355,
0.060273271054029465,
0.02380686067044735,
-0.0055223493836820126,
0.009937528520822525,
-0.017423080280423164,
-0.01546797901391983,
0.0004310538060963154,
-0.034630127251148224,
0.022791504859924316,
0.011871025897562504,
-0.05262569338083267,
0.03046068549156189,
0.024454960599541664,
-0.00432606553658843,
0.010283181443810463,
-0.03389561176300049,
0.0008938374812714756,
0.012000645510852337,
-0.0023426103871315718,
0.0005930787301622331,
0.012756762094795704,
-0.01628890447318554,
0.021549314260482788,
-0.0028759422712028027,
0.03637999668717384,
0.005146991461515427,
-0.021786950528621674,
0.0016837089788168669,
0.00011485203867778182,
-0.015554392710328102,
-0.018233204260468483,
-0.03126000612974167,
0.04502132534980774,
0.014420217834413052,
-0.028840435668826103,
0.028041113168001175,
0.032037727534770966,
0.009408246725797653,
0.020080288872122765,
0.016072871163487434,
-0.024800613522529602,
-0.017919955775141716,
0.022424248978495598,
0.05033574253320694,
0.050983842462301254,
-0.0019334973767399788,
0.004766233265399933,
0.008544114418327808,
-0.04331466183066368,
0.010553223080933094,
0.00818225834518671,
0.03149764612317085,
0.009051792323589325,
0.007210108917206526,
0.006875257473438978,
0.02248905971646309,
-0.021322479471564293,
0.006065133027732372,
0.04314183443784714,
0.02428213506937027,
0.02996380813419819,
0.04007416218519211,
-0.02957494929432869,
-0.015370763838291168,
0.019086536020040512,
-0.05431075394153595,
-0.019151344895362854,
-0.007355931214988232,
-0.021700536832213402,
-0.015403169207274914,
0.002778727328404784,
0.007550361100584269,
0.01237870380282402,
-0.01725025288760662,
0.003694168059155345,
0.004801338538527489,
-0.038237880915403366,
0.021300876513123512,
-0.010342590510845184,
0.015575995668768883,
0.012843174859881401,
0.04078707471489906,
0.012022249400615692,
-0.000057088469475274906,
-0.0064215874299407005,
0.0029488536529242992,
-0.0040398212149739265,
0.0004671718634199351,
0.00639998447149992,
0.01720704697072506,
0.009813309647142887,
-0.020004676654934883,
-0.04536697641015053,
0.001566240913234651,
-0.042666561901569366,
-0.010104954242706299,
0.01983185112476349,
0.03052549436688423,
0.04283938929438591,
-0.013944944366812706,
0.008473902940750122,
-0.020004676654934883,
0.01256233174353838,
-0.010266979224979877,
-0.015359962359070778,
0.028473179787397385,
0.004909355193376541,
0.0030487689655274153,
0.01236790232360363,
-0.0073019228875637054,
-0.006043529603630304,
0.0001216874661622569,
0.01547878049314022,
0.0203719325363636,
-0.017930757254362106,
0.009100399911403656,
-0.020058685913681984,
-0.00843069702386856,
-0.005951715167611837,
-0.006994075607508421,
-0.018287213519215584,
-0.014787474647164345,
-0.02428213506937027,
0.0282355435192585,
0.046576764434576035,
-0.000542783469427377,
0.025362301617860794,
-0.018643667921423912,
0.02378525771200657,
0.005263109691441059,
0.028041113168001175,
0.020458346232771873,
0.010083351284265518,
-0.0007878461619839072,
-0.008976180106401443,
-0.010871872305870056,
-0.025470318272709846,
-0.012130266055464745,
-0.01544637605547905,
-0.01726105436682701,
0.01590004563331604,
0.028537988662719727,
-0.016126880422234535,
-0.030179841443896294,
0.017012616619467735,
-0.004126234445720911,
0.0186004601418972,
-0.017055822536349297,
-0.0397501140832901,
-0.0032377978786826134,
-0.00440707802772522,
-0.012000645510852337,
0.004423280246555805,
0.015403169207274914,
-0.009165209718048573,
0.008895168080925941,
-0.009143606759607792,
-0.004588005598634481,
0.0055844588205218315,
0.026788119226694107,
-0.003416025312617421,
-0.003780581522732973,
-0.03007182478904724,
0.031173594295978546,
0.03307468816637993,
-0.014377010986208916,
0.02776026912033558,
0.027630649507045746,
0.02743621915578842,
-0.038173072040081024,
0.029337313026189804,
-0.009105800651013851,
-0.015489581972360611,
0.0025383904576301575,
-0.042623355984687805,
-0.006848253309726715,
-0.012465117499232292,
0.0013522329973056912,
-0.04757051542401314,
-0.04223449528217316,
-0.02212180197238922,
-0.0008033735794015229,
-0.03614236041903496,
0.02475740760564804,
-0.016202492639422417,
-0.002700415439903736,
0.020026279613375664,
0.01371810957789421,
-0.03916682302951813,
-0.04299061372876167,
0.009824111126363277,
0.00791221670806408,
0.008997783996164799,
-0.006448591593652964,
-0.01936737820506096,
0.028883641585707664,
0.051847975701093674,
0.008290275000035763,
-0.016450930386781693,
0.03800024464726448,
0.0015419371193274856,
-0.04713844880461693,
-0.024476565420627594,
-0.011892628856003284,
0.033312324434518814,
0.00397501140832901,
-0.051847975701093674,
-0.008263271301984787,
-0.0034241266548633575,
0.02782507985830307,
-0.0021468300838023424,
0.004752730950713158,
0.01583523489534855,
-0.004814840387552977,
0.047008831053972244,
-0.002808431861922145,
-0.024001291021704674,
-0.008527911268174648,
-0.0060003227554261684,
-0.007463947869837284,
-0.04718165844678879,
-0.01729346066713333,
-0.0159432515501976,
0.029942205175757408,
-0.01037499587982893,
-0.05297134816646576,
0.0016985612455755472,
-0.028970055282115936,
0.011892628856003284,
0.03149764612317085,
0.010067148134112358,
0.005719479639083147,
0.010844867676496506,
0.017109831795096397,
-0.0055628553964197636,
-0.0008060739492066205,
0.0005299564800225198,
0.0016107977135106921,
0.005589859560132027,
0.02512466348707676,
0.013826126232743263,
0.026334449648857117,
-0.010218371637165546,
-0.0075935679487884045,
0.001065988908521831,
-0.008695336990058422,
0.018730081617832184,
-0.013491274788975716,
0.012227480299770832,
0.007674580439925194,
-0.019129741936922073,
0.02832195535302162,
-0.0006575511069968343,
-0.013642498292028904,
-0.016645360738039017,
-0.046619970351457596,
-0.014258192852139473,
-0.006540406029671431,
-0.009008585475385189,
0.01669936813414097,
-0.0013252288335934281,
-0.028775624930858612,
0.004901253618299961,
-0.012130266055464745,
-0.02696094661951065,
-0.01850324496626854,
-0.0032404984813183546,
0.025038251653313637,
-0.02868921309709549,
-0.04029019549489021,
0.007755592931061983,
0.031584057956933975,
-0.019108138978481293,
-0.02070678398013115,
0.008706139400601387,
0.011309339664876461,
0.05271210893988609,
0.029812585562467575,
-0.00816065538674593,
-0.00432606553658843,
-0.04400596767663956,
0.008884366601705551,
-0.0003905475605279207,
-0.004674418829381466,
0.023958085104823112,
-0.01685059256851673,
0.017131434753537178,
0.003499738173559308,
-0.014787474647164345,
-0.01685059256851673,
-0.04378993436694145,
0.021074041724205017,
-0.01147136464715004,
0.010391198098659515,
-0.014787474647164345,
0.02380686067044735,
0.004053323529660702,
0.017498690634965897,
-0.021808553487062454,
-0.013782920315861702,
-0.011136513203382492,
-0.011082504875957966,
-0.010526219382882118,
0.05258248746395111,
-0.027933096513152122,
-0.03300987556576729,
-0.035083796828985214,
0.017714723944664,
-0.015619202516973019,
-0.03879956901073456,
0.02343960478901863,
0.028797229751944542,
0.003659062786027789,
0.007544960360974073,
0.017520295456051826,
-0.026852929964661598,
0.0030136634595692158,
-0.05228004232048988,
-0.007901415228843689,
0.019713031128048897,
-0.010515416972339153,
0.03190810605883598,
0.009829511865973473,
0.004010116681456566,
-0.010283181443810463,
0.013556084595620632,
0.018676072359085083,
0.008068840950727463,
0.003178388811647892,
-0.05301455408334732,
-0.019734635949134827,
-0.04283938929438591,
-0.017725525423884392,
-0.026809724047780037,
0.06390263140201569,
0.022424248978495598,
0.0370929054915905,
0.015511185862123966,
-0.00231020525097847,
-0.0008033735794015229,
-0.04100310802459717,
-0.000041539984522387385,
0.013912539929151535,
-0.015370763838291168,
-0.009235420264303684,
-0.005611462984234095,
0.00857651885598898,
-0.004169441293925047,
-0.008527911268174648,
0.037222523242235184,
0.0025262385606765747,
0.03661763295531273,
-0.02216500975191593,
0.016224095597863197,
-0.02339639887213707,
-0.02072838880121708,
0.10144920647144318,
-0.02430373802781105,
0.021257668733596802,
0.0028975456953048706,
-0.028127526864409447,
-0.012745960615575314,
0.038108259439468384,
0.00015021060244180262,
-0.008036435581743717,
-0.005600661505013704,
-0.01150376908481121,
0.028408369049429893,
0.05301455408334732,
0.06748878210783005,
0.022877918556332588,
-0.0033701183274388313,
0.0021346784196794033,
-0.00027561114984564483,
-0.02158171869814396,
-0.027479426935315132,
-0.023050745949149132,
0.006589013617485762,
0.007820403203368187,
-0.009883520193397999,
-0.009435251355171204,
0.0036239572800695896,
0.005595260765403509,
-0.019540205597877502,
-0.011622587218880653,
-0.02382846549153328,
0.008878965862095356,
-0.011179719120264053,
0.03149764612317085,
-0.032448191195726395,
0.02030712366104126,
0.010072548873722553,
-0.007750192191451788,
-0.042083270847797394,
-0.015792028978466988,
0.025707954540848732,
0.008484705351293087,
-0.008792552165687084,
-0.03752497211098671,
0.010202169418334961,
0.011622587218880653,
0.011784612201154232,
-0.017379872500896454,
-0.011806216090917587,
0.02786828577518463,
-0.019237758591771126,
0.03087114728987217,
-0.03171367943286896,
0.004588005598634481,
0.031173594295978546,
-0.00045333223533816636,
-0.02032872661948204,
0.002619402948766947,
0.00528471264988184,
0.0050794812850654125,
-0.015295152552425861,
-0.004174842033535242,
0.029898999258875847,
0.011903430335223675,
-0.031476039439439774,
0.031108785420656204
] | 2024-07-05 | 1 | 38963989 | [
"myeloma treatment",
"multiple myeloma",
"novel treatment modalities",
"Current treatment landscape",
"infectious complications",
"risk factors",
"specific risk",
"infectious disease prophylaxis",
"distinct pattern",
"pattern",
"patterns",
"immunomodulatory drugs",
"different classes",
"different stages",
"Infections",
"infections",
"complex procedures",
"unique mechanism",
"drugs",
"proteasome inhibitors",
"bispecific T-cell engagers",
"complications",
"major cause",
"chimeric antigen receptor T-lymphocytes",
"autologous and allogeneic hematopoietic cell transplantation",
"patients",
"action",
"morbidity",
"mortality",
"evidence"
] | [
"Bispecific antibodies",
"CAR-T",
"Infections",
"Infectious complications",
"Multiple myeloma",
"Prophylaxis"
] | 0 | 10.1016/j.leukres.2024.107544 | [
"Akhmedov",
"Zeynalova",
"Fedenko"
] | [
"Department of High-dose Chemotherapy and Bone Marrow Transplantation, P.A. Herzen Moscow Oncology Research Institute, branch of the National Medical Radiology Research Center, Russian Federation; Department of Oncology and Oncosurgery, Russian University of Medicine, Russian Federation. Electronic address: [email protected].",
"Department of Oncology, Sechenov University, Russian Federation; Department of Oncology, Lapino Clinical Hospital, Russian Federation.",
"Department of High-dose Chemotherapy and Bone Marrow Transplantation, P.A. Herzen Moscow Oncology Research Institute, branch of the National Medical Radiology Research Center, Russian Federation."
] | [
"38963989"
] | [] | 4.87433 | 6.418158 |
38963636 | 764 | CAR-T cell therapy in AML: recent progress and future perspectives. | Despite several small-molecule drugs that have revolutionized the current treatment strategy for acute myeloid leukemia (AML), hematopoietic stem cell transplantation remains the only curative treatment in most cases to date. Chimeric antigen receptor (CAR)-T cell therapy is one of the most promising next-generation cancer therapies for hematological malignancies and is clinically available for treatment of AML. However, developing AML-targeted CAR-T therapy is challenging because of the heterogeneity of target antigen expression across leukemic cells and patients, the difficulty in excluding on-/off-target tumor effects, and the immunosuppressive tumor microenvironment. To date, various targets, including CD33, NKG2D, CD123, CLL-1, and CD7, have been actively studied for CAR-T cells. Although no CAR-T cell products are close to practical use, several clinical trials have shown promising results, particularly for CAR-T cells targeting CLL-1 or CD123. Meanwhile, research exploring the ideal target for AML-targeted CAR-T therapy continues. Furthermore, as collecting autologous lymphocytes from patients with AML is difficult, development of off-the-shelf CAR-T products is being actively pursued. This review discusses the challenges in AML-targeted CAR-T cell therapy development from the perspectives of target antigen characteristics and AML-specific on-target/off-tumor toxicity. Moreover, it discusses the clinical development and prospects of AML-targeting CAR-T cells. | [
0.00715057784691453,
0.010379155166447163,
0.0586247518658638,
0.03834351524710655,
-0.01711922697722912,
-0.010767471976578236,
0.007483420893549919,
0.026982475072145462,
0.002917923964560032,
-0.010711997747421265,
-0.0024144987110048532,
-0.05298861116170883,
-0.056317038834095,
0.02631678804755211,
-0.0005731140845455229,
-0.04025181755423546,
0.05414246395230293,
-0.012592561542987823,
0.023232443258166313,
0.017929144203662872,
0.02718218043446541,
0.028091952204704285,
0.005236730445176363,
-0.007455683778971434,
-0.023232443258166313,
-0.02573985978960991,
0.001646186108700931,
-0.006251901388168335,
-0.048506323248147964,
-0.008898003958165646,
0.0194158423691988,
-0.02141290158033371,
-0.021634796634316444,
0.009430552832782269,
0.015344063751399517,
0.05649455636739731,
0.03128724545240402,
0.016497919335961342,
0.002028955612331629,
-0.01939365454018116,
0.024963226169347763,
0.01666434109210968,
0.039452992379665375,
0.03679024800658226,
-0.05964547023177147,
0.002275814302265644,
0.0022203403059393167,
-0.03721185028553009,
-0.023898128420114517,
-0.015732379630208015,
0.0033339776564389467,
0.002917923964560032,
-0.02875763736665249,
0.032130446285009384,
-0.035547636449337006,
0.03903139382600784,
-0.030998781323432922,
-0.022666610777378082,
0.043913088738918304,
0.0018694683676585555,
-0.015144357457756996,
0.008138012140989304,
-0.0033367513678967953,
-0.01162731647491455,
-0.05449749901890755,
0.010817398317158222,
-0.048639461398124695,
-0.04681991785764694,
0.0002355904580326751,
0.022810842841863632,
-0.005220088176429272,
-0.038010671734809875,
0.017429878935217857,
0.012259718030691147,
0.0011746585369110107,
-0.010362512432038784,
-0.029378945007920265,
0.019282706081867218,
0.0078329062089324,
0.011838116683065891,
0.02831384725868702,
-0.014057070016860962,
0.005106366705149412,
-0.03568077087402344,
0.007960495539009571,
-0.0003723681438714266,
0.006507080979645252,
-0.021202100440859795,
-0.034415967762470245,
-0.020946921780705452,
-0.029844924807548523,
-0.016719814389944077,
-0.043025508522987366,
0.054675012826919556,
0.0024491699878126383,
0.021146627143025398,
0.002284135203808546,
-0.044490016996860504,
0.03091002255678177,
0.03002244047820568,
0.024963226169347763,
0.024186592549085617,
-0.021235385909676552,
-0.032840512692928314,
0.04309207573533058,
-0.023232443258166313,
-0.0048123556189239025,
-0.0058968691155314445,
0.027648160234093666,
-0.015288589522242546,
0.058136582374572754,
-0.019038621336221695,
0.0002342036023037508,
0.05374305322766304,
-0.053964950144290924,
-0.06909821182489395,
-0.044756293296813965,
0.014423198066651821,
0.014744945801794529,
0.016031939536333084,
-0.032418910413980484,
0.036168940365314484,
0.02485227957367897,
-0.012548182159662247,
0.014101449400186539,
-0.020447656512260437,
0.102249376475811,
-0.021623702719807625,
-0.03865417093038559,
-0.030510609969496727,
0.04903887212276459,
0.00009959287126548588,
-0.011760453693568707,
-0.014900272712111473,
-0.07557755708694458,
-0.01622055098414421,
-0.014134733937680721,
0.010440176352858543,
-0.023587476462125778,
0.0006310148746706545,
0.022455809637904167,
-0.019049715250730515,
-0.022311577573418617,
0.019659927114844322,
-0.021867787465453148,
-0.039142340421676636,
0.01883891597390175,
0.03918671980500221,
-0.004412943962961435,
0.05436436086893082,
0.006307375151664019,
0.028646688908338547,
0.05445311963558197,
-0.004573817830532789,
0.0019401974277570844,
-0.023676233366131783,
-0.005672200117260218,
0.06350644677877426,
-0.021668080240488052,
-0.059423573315143585,
-0.0006920361192896962,
0.0057470896281301975,
-0.04859508201479912,
-0.037722211331129074,
-0.016986088827252388,
-0.0016974994214251637,
-0.03778877854347229,
0.008032611571252346,
-0.04384652152657509,
0.028269467875361443,
-0.01336919516324997,
-0.05431998148560524,
-0.06195318326354027,
-0.037855345755815506,
-0.04042933136224747,
-0.01752973347902298,
0.006495986599475145,
0.00034948516986332834,
-0.03503727540373802,
-0.025828618556261063,
0.012614750303328037,
0.02689371630549431,
0.03745593503117561,
-0.008898003958165646,
-0.0304662324488163,
0.029245806857943535,
-0.031819794327020645,
-0.0019748685881495476,
-0.046065475791692734,
-0.024608194828033447,
0.0205696988850832,
-0.0008695524302311242,
0.02125757373869419,
0.019005335867404938,
0.011011556722223759,
0.014822609722614288,
0.04193822294473648,
0.03849884495139122,
-0.006479344330728054,
-0.03346182033419609,
0.03807724267244339,
-0.01680857315659523,
-0.04384652152657509,
-0.016719814389944077,
-0.021290859207510948,
0.008814793080091476,
-0.0030344189144670963,
0.03985240310430527,
-0.0009354276116937399,
0.016775287687778473,
0.0414278618991375,
-0.020758310332894325,
-0.012415044941008091,
0.05986736714839935,
-0.041316915303468704,
-0.016852952539920807,
-0.039586130529642105,
0.033839039504528046,
0.0117715485394001,
0.04451220855116844,
0.00775524228811264,
-0.015044504776597023,
-0.0238315612077713,
0.03991897404193878,
-0.051346585154533386,
0.012071107514202595,
0.005408699158579111,
-0.04233763366937637,
0.00531716737896204,
-0.02616146206855774,
0.003181424690410495,
0.004948266316205263,
0.021656986325979233,
-0.001219037570990622,
-0.011982348747551441,
-0.04329178109765053,
-0.01092279888689518,
0.006484891753643751,
0.03918671980500221,
-0.019482411444187164,
0.015499390661716461,
0.027381885796785355,
0.036279890686273575,
-0.05214540660381317,
0.00253376760520041,
-0.025229500606656075,
-0.013025256805121899,
-0.04686429724097252,
0.03568077087402344,
-0.0015172094572335482,
0.018905483186244965,
-0.0015088884392753243,
-0.0029928134754300117,
-0.005946795456111431,
0.02257785201072693,
0.005464172922074795,
0.03102096915245056,
-0.054541878402233124,
0.019781971350312233,
-0.013568900525569916,
-0.010606598109006882,
0.03319554403424263,
-0.03996335342526436,
-0.025806428864598274,
-0.0396970771253109,
0.02973397634923458,
-0.013335910625755787,
0.022622231394052505,
0.03348400816321373,
-0.013602185063064098,
0.006196427624672651,
0.025185123085975647,
0.03494851663708687,
-0.01653120294213295,
-0.030377473682165146,
-0.014478671364486217,
-0.021634796634316444,
0.03264080733060837,
0.012692414224147797,
0.029689596965909004,
0.012071107514202595,
-0.00961916334927082,
0.019493507221341133,
-0.009075519628822803,
0.011827021837234497,
-0.0014894725754857063,
0.0006903025787323713,
-0.02569548226892948,
-0.0032479932997375727,
-0.02718218043446541,
0.019138474017381668,
-0.01969321258366108,
-0.023188063874840736,
-0.03732279688119888,
0.004332506563514471,
-0.010018575005233288,
0.009336247108876705,
-0.014700567349791527,
-0.038587599992752075,
0.03561420366168022,
-0.0069120400585234165,
0.014467576518654823,
-0.0036057995166629553,
-0.0493939034640789,
0.04138348251581192,
0.01544391643255949,
0.010107332840561867,
-0.0009056103881448507,
0.02272208407521248,
0.03377247229218483,
0.03818818926811218,
0.003278503892943263,
0.0615093894302845,
-0.0008993695955723524,
-0.005514099262654781,
-0.002250850899145007,
-0.015199831686913967,
-0.06767807900905609,
0.0011406807461753488,
-0.012326287105679512,
-0.03146475926041603,
-0.036457404494285583,
-0.020880352705717087,
0.03605799376964569,
0.011749358847737312,
-0.026560872793197632,
0.04069560766220093,
-0.03408312425017357,
0.04571044072508812,
-0.04770750179886818,
-0.002270266879349947,
-0.05605076625943184,
0.06434965133666992,
-0.013735322281718254,
-0.009486026130616665,
-0.02124647982418537,
-0.013835174962878227,
-0.04668678343296051,
0.02917923778295517,
0.006629123818129301,
-0.0009402815485373139,
0.0148004200309515,
-0.022877410054206848,
0.04213792830705643,
-0.02110224775969982,
-0.02731531672179699,
-0.004099516663700342,
0.0009472157689742744,
-0.0008744063670746982,
0.03590266779065132,
-0.007644294761121273,
0.009097709320485592,
0.026827147230505943,
0.006201975047588348,
-0.01823979802429676,
0.05289985239505768,
-0.040007732808589935,
-0.013668753206729889,
0.02010371908545494,
0.01078411377966404,
0.02054750919342041,
0.007311451714485884,
-0.051524098962545395,
0.029955871403217316,
0.06146501377224922,
0.05418684333562851,
-0.009596973657608032,
0.010334775783121586,
-0.021878881379961967,
-0.057115864008665085,
-0.011166883632540703,
0.007766337133944035,
0.0208581630140543,
-0.008004874922335148,
-0.019149567931890488,
0.04320302605628967,
0.012115485966205597,
0.015920991078019142,
0.03568077087402344,
0.03308459743857384,
0.02818070910871029,
-0.027648160234093666,
0.005181256216019392,
-0.00976894237101078,
-0.029534270986914635,
0.034837570041418076,
0.008726034313440323,
-0.01220424473285675,
-0.10003042221069336,
0.023809371516108513,
-0.002490775194019079,
-0.03765564039349556,
0.0029844925738871098,
0.01077856682240963,
-0.017485354095697403,
0.06483782082796097,
-0.03781096637248993,
0.08183500170707703,
0.050503380596637726,
-0.012159865349531174,
0.013469047844409943,
-0.034105315804481506,
-0.005092498380690813,
-0.024497246369719505,
0.020347803831100464,
-0.02527387998998165,
0.007555536460131407,
0.022045303136110306,
0.007000798359513283,
-0.02556234411895275,
0.007477873470634222,
0.026560872793197632,
0.03705652430653572,
0.016730910167098045,
-0.0016018070746213198,
-0.009391720406711102,
-0.06909821182489395,
0.05693834647536278,
-0.02471914142370224,
0.013025256805121899,
0.02329901233315468,
-0.05059213936328888,
0.016708720475435257,
-0.016276024281978607,
-0.003325656522065401,
0.010184996761381626,
0.07992670685052872,
0.028202898800373077,
-0.01258146669715643,
-0.03789972513914108,
-0.025118554010987282,
0.05560697615146637,
0.04242639243602753,
-0.022245008498430252,
-0.006906492635607719,
0.03923109918832779,
-0.01739659532904625,
0.02986711449921131,
-0.006773355416953564,
-0.013391384854912758,
-0.03091002255678177,
0.016142886132001877,
-0.006906492635607719,
-0.012814456596970558,
0.03157570958137512,
0.024031266570091248,
-0.007960495539009571,
0.04096188023686409,
-0.04014086723327637,
-0.0012481613084673882,
-0.022067492827773094,
-0.05356553941965103,
-0.005713805090636015,
0.004784618504345417,
-0.023942507803440094,
-0.03880949690937996,
0.028069762513041496,
-0.06474906206130981,
0.009458289481699467,
0.04191603139042854,
0.02054750919342041,
-0.060444291681051254,
0.014045976102352142,
-0.027648160234093666,
-0.044467829167842865,
0.019193947315216064,
0.05520756170153618,
-0.022644421085715294,
0.03488194942474365,
-0.0032174824737012386,
0.03477100282907486,
0.00280281575396657,
-0.01752973347902298,
0.008554065600037575,
-0.013779701665043831,
0.07677578926086426,
0.013879554346203804,
0.01034032367169857,
0.03308459743857384,
0.0022189535666257143,
-0.013912838883697987,
-0.005630594678223133,
-0.036590542644262314,
-0.01694170944392681,
0.009158730506896973,
-0.01524421013891697,
-0.038432274013757706,
0.00970237422734499,
-0.02629459835588932,
0.0319085530936718,
-0.008637276478111744,
-0.013358100317418575,
0.0159542765468359,
-0.00813246425241232,
0.0001830636610975489,
-0.026250220835208893,
-0.008554065600037575,
-0.008237864822149277,
-0.01626492850482464,
0.011100314557552338,
-0.030399663373827934,
-0.00004110698137083091,
0.022644421085715294,
0.031398192048072815,
0.04655364528298378,
0.032108258455991745,
0.023676233366131783,
0.0417163260281086,
-0.00399134261533618,
0.05334364250302315,
-0.04071779549121857,
-0.012492707930505276,
0.03102096915245056,
-0.020935826003551483,
-0.03246328979730606,
-0.033350870013237,
-0.06008926033973694,
0.011261189356446266,
0.0020220214501023293,
0.004926076624542475,
-0.004482286050915718,
-0.013613279908895493,
0.0019540658686310053,
0.008737129159271717,
0.021146627143025398,
-0.0013029417023062706,
-0.0368124395608902,
0.022178439423441887,
-0.030000250786542892,
-0.014401008374989033,
0.023232443258166313,
-0.0017696154536679387,
-0.02571767196059227,
0.02010371908545494,
-0.0353701189160347,
-0.040606848895549774,
-0.03909796103835106,
0.02527387998998165,
-0.030688127502799034,
-0.021157721057534218,
0.004379659425467253,
-0.014256776310503483,
0.021046774461865425,
-0.005869132000952959,
-0.0069120400585234165,
0.008581802248954773,
-0.006196427624672651,
-0.024807900190353394,
0.017274552956223488,
-0.022622231394052505,
0.017718343064188957,
-0.029955871403217316,
0.01825089193880558,
-0.0003584996738936752,
0.02527387998998165,
-0.023942507803440094,
-0.03517041355371475,
-0.02702685445547104,
-0.01837293431162834,
-0.033128976821899414,
-0.033128976821899414,
-0.010939440689980984,
-0.013957217335700989,
-0.007455683778971434,
-0.007128388155251741,
0.030976591631770134,
-0.015699096024036407,
-0.02010371908545494,
-0.02556234411895275,
0.03221920505166054,
0.01127228420227766,
0.0035003991797566414,
-0.0034227357245981693,
-0.028402604162693024,
0.026538683101534843,
0.00711174588650465,
-0.006379491183906794,
0.010883967392146587,
-0.0007586047286167741,
0.02802538312971592,
-0.013912838883697987,
-0.008592897094786167,
-0.02929018624126911,
0.04107283055782318,
0.007566631305962801,
0.0070618195459246635,
-0.0511246882379055,
-0.007322546560317278,
-0.011682789772748947,
0.00926967803388834,
0.05605076625943184,
-0.016553392633795738,
0.02917923778295517,
0.021734649315476418,
-0.05795906484127045,
0.0009312670445069671,
0.014633998274803162,
-0.02929018624126911,
-0.0036446312442421913,
-0.017929144203662872,
-0.0030538346618413925,
0.0017016599886119366,
-0.024253161624073982,
-0.026494305580854416,
-0.01969321258366108,
0.022788653150200844,
-0.016642151400446892,
-0.022466903552412987,
0.018339650705456734,
0.020236855372786522,
0.035148221999406815,
0.02829165756702423,
-0.033395249396562576,
-0.005089724436402321,
0.04974893853068352,
0.013591090217232704,
-0.014844798482954502,
-0.008309980854392052,
-0.005270014517009258,
-0.012137675657868385,
-0.024497246369719505,
-0.014767135493457317,
-0.014744945801794529,
-0.006046648137271404,
0.0042825802229344845,
-0.04855070263147354,
-0.016575582325458527,
0.006579197011888027,
-0.0012273587053641677,
0.0013632695190608501,
-0.024830089882016182,
-0.03062155842781067,
-0.017407691106200218,
0.02789224497973919,
-0.0018888841150328517,
-0.032130446285009384,
0.030288714915513992,
-0.04522227123379707,
0.001847278792411089,
0.026361167430877686,
-0.02416440285742283,
0.038299135863780975,
-0.011594031937420368,
-0.01937146484851837,
0.005852489732205868,
-0.014534145593643188,
-0.0244084894657135,
-0.0078329062089324,
0.0057470896281301975,
-0.026250220835208893,
0.008210128173232079,
-0.021435091271996498,
0.04588795825839043,
-0.0321970134973526,
0.013613279908895493,
-0.013879554346203804,
0.008032611571252346,
-0.0062075224705040455,
0.08436461538076401,
0.0789947435259819,
-0.03128724545240402,
0.0139350276440382,
-0.011322210542857647,
0.0202812347561121,
-0.01765177585184574,
-0.010773018933832645,
0.02598394639790058,
-0.006163143552839756,
-0.004107837565243244,
0.013402478769421577,
0.03679024800658226,
0.033683713525533676,
-0.023343391716480255,
-0.005031477194279432,
-0.021313048899173737,
0.0036501784343272448,
0.001967934425920248,
-0.010479007847607136,
-0.04841756448149681,
-0.0014367724070325494,
-0.0006601386703550816,
-0.011616221629083157,
-0.051524098962545395,
-0.047174952924251556,
-0.0018597603775560856,
0.003522588638588786,
0.046908676624298096,
0.019881824031472206,
0.010234923101961613,
-0.023321202024817467,
0.01098382007330656,
-0.017274552956223488,
-0.03501508757472038,
-0.000333536445396021,
0.03909796103835106,
0.017563017085194588,
0.0023826013784855604,
-0.010806303471326828,
-0.04588795825839043,
-0.014101449400186539,
0.022744273766875267,
0.008221223019063473,
0.04511132463812828,
-0.01465618796646595,
0.005394830834120512,
-0.005874679423868656,
0.013968312181532383,
-0.024230971932411194,
0.006401680875569582,
0.04500037804245949,
0.007516704965382814,
-0.030843453481793404,
-0.01683076284825802,
-0.0073003568686544895,
-0.028424793854355812,
0.012270812876522541,
0.0036141204182058573,
0.041161589324474335,
0.005835847929120064,
0.02400907687842846,
0.010617692954838276,
0.03434940055012703,
-0.03519260138273239,
0.02569548226892948,
0.016486825421452522,
0.03233015164732933,
-0.02642773650586605,
0.06798873841762543,
-0.0027570496313273907,
-0.030554989352822304,
0.013735322281718254,
-0.007084009237587452,
-0.02283303067088127,
-0.02957865037024021,
-0.0150888841599226,
0.0184062197804451,
-0.0075444420799613,
-0.00026644777972251177,
-0.019715402275323868,
-0.007250430528074503,
0.04071779549121857,
-0.025473585352301598,
-0.022644421085715294,
0.01709703728556633,
-0.025673292577266693,
0.01998167671263218,
0.023676233366131783,
0.006706786807626486,
-0.011949064210057259,
-0.0048206765204668045,
-0.0084819495677948,
0.006390586029738188,
0.006629123818129301,
-0.02053641527891159,
0.011006009764969349,
-0.02915704995393753,
-0.012381760403513908,
-0.011416515335440636,
-0.03317335620522499,
-0.01984853856265545,
-0.008182390592992306,
0.01924942247569561,
-0.0007745534530840814,
0.01681966707110405,
0.003694557584822178,
0.007095103617757559,
0.021468374878168106,
0.0359470471739769,
0.022344861179590225,
0.014290060847997665,
-0.021446185186505318,
-0.0033672619611024857,
0.03317335620522499,
-0.04380214214324951,
-0.009097709320485592,
0.020880352705717087,
-0.0084819495677948,
0.012348475866019726,
-0.017729438841342926,
0.001381992013193667,
-0.006706786807626486,
0.0017640680307522416,
-0.023520907387137413,
0.0039802477695047855,
0.016997184604406357,
-0.018017902970314026,
-0.008465307764708996,
0.029667409136891365,
-0.019349275156855583,
0.005355998873710632,
-0.027670349925756454,
0.03852103278040886,
-0.027559403330087662,
0.0139350276440382,
-0.013025256805121899,
0.01767396554350853,
0.05307736620306969,
-0.06829939037561417,
-0.027692539617419243,
-0.019449127838015556,
-0.008498592302203178,
0.0032563142012804747,
0.007716410793364048,
-0.04220449551939964,
0.018639208748936653,
0.01867249421775341,
-0.007416852284222841,
0.025473585352301598,
-0.018206514418125153,
0.008576255291700363,
-0.0005131330108270049,
-0.013324815779924393,
-0.024541625753045082,
-0.015632526949048042,
-0.062308214604854584,
-0.01494465209543705,
0.048373185098171234,
0.013413573615252972,
-0.00740021001547575,
-0.00975784845650196,
0.04180508479475975,
-0.018506072461605072,
-0.00553628895431757,
-0.013413573615252972,
-0.015754569321870804,
-0.04082874581217766,
-0.008592897094786167,
0.017196889966726303,
0.016009749844670296,
-0.02875763736665249,
0.03330649062991142,
0.0009770329343155026,
-0.028535742312669754,
0.015565958805382252,
-0.009669089689850807,
-0.01982634887099266,
-0.0030122294556349516,
-0.009807774797081947,
0.03206387907266617,
0.040163058787584305,
0.004926076624542475,
-0.012758982367813587,
-0.02213406190276146,
-0.03272956237196922,
-0.0020026054698973894,
0.02889077551662922,
-0.01679747737944126,
0.010750830173492432,
-0.012625845149159431,
-0.034571293741464615,
-0.0030538346618413925,
0.011205715127289295,
-0.01969321258366108,
-0.02644992619752884,
0.0241200253367424,
0.025517964735627174,
0.007710863370448351,
-0.0041383481584489346,
0.056272659450769424,
0.02243361994624138,
-0.00502870324999094,
-0.015122167766094208,
-0.013901744037866592,
-0.059822987765073776,
0.04122815653681755,
-0.04628736898303032,
0.012304097414016724,
-0.011871401220560074,
-0.0017834838945418596,
-0.045621685683727264,
0.012559277005493641,
0.014478671364486217,
-0.006329564843326807,
-0.009486026130616665,
-0.021213196218013763,
-0.016020843759179115,
-0.0014756041346117854,
-0.027204370126128197,
-0.013879554346203804,
-0.023077117279171944,
-0.010162807069718838,
-0.0414278618991375,
-0.016864046454429626,
0.02398688718676567,
-0.007427946664392948,
0.01852826215326786,
-0.01826198771595955,
0.00015194631123449653,
-0.01107257790863514,
-0.007938305847346783,
0.0015990333631634712,
-0.022899599745869637,
-0.011782643385231495,
-0.012015633285045624,
0.01005185954272747,
0.016986088827252388,
-0.012636939994990826,
0.040473710745573044,
-0.037855345755815506,
0.02545139752328396,
-0.02474133111536503,
-0.02285522036254406,
-0.01937146484851837,
0.03264080733060837,
-0.02644992619752884,
0.009580331854522228,
-0.0027598233427852392,
0.031087538227438927,
-0.009192015044391155,
0.017440974712371826,
-0.0037833156529814005,
0.0145119559019804,
0.03696776553988457,
0.009868795983493328,
-0.006734523922204971,
0.004956587217748165,
0.0037111996207386255,
0.06284075975418091,
0.04926076903939247,
-0.011172430589795113,
-0.03130943328142166,
-0.02516293339431286,
-0.002278587780892849,
0.01113359909504652,
0.016176171600818634,
-0.002668291563168168,
0.0041300272569060326,
0.03818818926811218,
0.018051186576485634,
-0.0013064088998362422,
-0.01797352358698845,
-0.00041189324110746384,
0.01063433475792408,
0.03889825567603111,
0.02718218043446541,
-0.00798823218792677,
0.02773691900074482,
0.01092279888689518,
0.005630594678223133,
-0.003397772554308176,
-0.009641353040933609,
0.060000501573085785,
-0.015432821586728096,
-0.046198610216379166,
0.0275815911591053,
0.0021426770836114883,
0.0017820970388129354,
-0.005159066990017891,
0.026627441868185997,
0.029667409136891365,
0.05995612218976021,
-0.008409833535552025,
-0.006079932674765587,
0.001578230643644929,
-0.0324854776263237,
-0.036168940365314484,
0.02715999074280262,
-0.030932212248444557,
0.027359696105122566,
-0.039430804550647736,
-0.014478671364486217,
-0.0027570496313273907,
-0.003162008710205555,
0.000501691538374871,
0.008015969768166542,
0.03173103556036949,
0.028247278183698654,
0.020325614139437675,
-0.04846194386482239,
0.047485604882240295,
-0.028846396133303642,
-0.0022813614923506975,
0.018173228949308395,
0.015554863959550858,
-0.005239503923803568,
0.014323344454169273,
0.04342491924762726,
-0.03592485561966896,
-0.001646186108700931,
0.01538844220340252,
0.037012144923210144,
0.017130320891737938,
-0.029489891603589058,
-0.014989030547440052,
-0.024319730699062347,
-0.0013327589258551598,
-0.011671695858240128,
-0.008814793080091476,
-0.032108258455991745,
0.001876402529887855,
0.039896782487630844,
0.04284799098968506,
-0.028691068291664124,
-0.022877410054206848,
0.02571767196059227,
-0.03809943050146103,
-0.02789224497973919,
-0.03889825567603111,
0.04588795825839043,
0.04424593225121498,
-0.01157184224575758,
-0.021956544369459152,
0.008603991940617561,
-0.007533347234129906,
-0.007328093983232975,
-0.022100776433944702,
0.050947170704603195,
-0.02500760555267334,
0.05303299054503441,
-0.052367303520441055,
0.046331748366355896,
0.025651102885603905,
0.022455809637904167,
0.011105862446129322,
0.007527799811214209,
-0.020092623308300972,
-0.011000461876392365,
-0.055651355534791946,
-0.03224139288067818,
0.004493380896747112,
-0.03754469379782677,
0.01880563050508499,
-0.004024626687169075,
0.046464886516332626,
-0.0023396092001348734,
0.006495986599475145,
0.008997856639325619,
-0.008892456069588661,
0.02469695173203945,
0.0281585194170475,
-0.0003023324243258685,
-0.020736120641231537,
0.006024458911269903,
-0.00542256748303771,
-0.016486825421452522,
0.013169488869607449,
0.0022605587728321552,
0.06971951574087143,
0.04386870935559273,
0.0033811302855610847,
-0.029512081295251846,
-0.015288589522242546,
0.01524421013891697,
0.046198610216379166,
-0.025318259373307228,
-0.02039218321442604,
-0.014822609722614288,
-0.02227829396724701,
-0.010157260112464428,
0.03144257143139839,
0.03377247229218483,
0.033816851675510406,
0.026472115889191628,
0.004257617052644491,
0.01837293431162834,
0.025606723502278328,
0.010462366044521332,
-0.01055667083710432,
-0.007954948581755161,
-0.012825551442801952,
-0.007022988051176071,
0.0036196678411215544,
0.008565160445868969,
-0.0025462491903454065,
-0.034682244062423706,
0.03330649062991142,
0.021080058068037033,
0.019726496189832687,
0.004823449999094009,
-0.02773691900074482,
0.0011080899275839329,
-0.015577053651213646,
-0.010678714141249657,
0.025828618556261063,
-0.003622441552579403,
0.00499819265678525,
-0.007072914391756058,
0.0014672830002382398,
-0.009596973657608032,
-0.024608194828033447,
-0.007566631305962801,
0.024253161624073982,
0.014645093120634556,
-0.01826198771595955,
-0.004640386439859867,
-0.020580794662237167,
-0.016131792217493057,
-0.010595503263175488,
0.013735322281718254,
-0.032574236392974854,
-0.005441983696073294,
-0.01578785479068756,
-0.012814456596970558,
0.003392225131392479,
-0.002779239322990179,
-0.011827021837234497,
-0.010617692954838276,
-0.00853742379695177,
0.03996335342526436,
0.0025309938937425613,
-0.0033284302335232496,
-0.0017904180567711592,
-0.021080058068037033,
-0.03459348529577255,
-0.06350644677877426,
0.0476631224155426,
-0.0009818868711590767,
-0.052944231778383255,
0.040029920637607574,
0.03002244047820568,
-0.029534270986914635,
0.003935868851840496,
-0.00007666657620575279,
-0.011122504249215126,
0.008437571115791798,
0.021468374878168106,
0.009169825352728367,
-0.021523848176002502,
0.006068837828934193,
-0.004221559036523104,
-0.0021815085783600807,
-0.037167470902204514,
-0.007561083883047104,
0.00841538142412901,
0.004160537850111723,
-0.016276024281978607,
-0.04014086723327637,
0.0017654548864811659,
-0.00827114935964346,
0.010096237994730473,
0.0024034040980041027,
0.02556234411895275,
0.007089556660503149,
0.005924605764448643,
-0.004546081181615591,
-0.0004160537791904062,
-0.020480940118432045,
-0.01553267426788807,
-0.020514225587248802,
-0.0024963226169347763,
0.036457404494285583,
0.00941391009837389,
-0.014068164862692356,
-0.00632401742041111,
-0.022012019529938698,
-0.013391384854912758,
-0.02214515581727028,
0.054808150976896286,
-0.02271098829805851,
-0.04484505206346512,
0.03608018532395363,
0.01258146669715643,
-0.0038831685669720173,
-0.024785710498690605,
-0.007849548012018204,
-0.012758982367813587,
0.001233599497936666,
-0.0037555787712335587,
0.02372061274945736,
0.048639461398124695,
-0.015022315084934235,
0.0004836625303141773,
0.0005103592993691564,
-0.006257448811084032,
-0.0036141204182058573,
0.0011933809146285057,
0.018295271322131157,
0.022455809637904167,
0.01436772383749485,
-0.02474133111536503,
0.014168018475174904,
0.01668653078377247,
0.019471317529678345,
0.058003444224596024,
0.03193074092268944,
-0.0032757301814854145,
0.01636478118598461,
-0.006867661140859127,
0.010506744496524334,
-0.009341794066131115,
-0.023077117279171944,
-0.013923932798206806,
-0.020780500024557114,
-0.02585080824792385,
-0.026827147230505943,
-0.002467198995873332,
-0.006140953861176968,
0.00274595501832664,
0.007244883105158806,
0.008959025144577026,
-0.01191578060388565,
-0.03625769913196564,
-0.006102122366428375,
-0.0035114940255880356,
-0.010118427686393261,
-0.02458600513637066,
0.02715999074280262,
-0.03186417371034622,
-0.01272569876164198,
-0.0015629753470420837,
0.001521370024420321,
0.02789224497973919,
0.03588047996163368,
0.011671695858240128,
0.021901071071624756,
0.01768505945801735,
0.007821811363101006,
-0.010534482076764107,
0.0002709550317376852,
-0.07349173724651337,
-0.0012883798917755485,
-0.02153494395315647,
0.001771002309396863,
-0.007339188829064369,
-0.0012453875970095396,
-0.03823256865143776,
0.006201975047588348,
0.00798268523067236,
-0.011405421420931816,
-0.012692414224147797,
-0.006851018872112036,
0.018761251121759415,
0.01020163856446743,
0.008603991940617561,
-0.001098381937481463,
-0.026338977739214897,
0.017563017085194588,
0.002246690448373556,
0.012481613084673882,
0.023654043674468994,
-0.017063751816749573,
-0.039142340421676636,
-0.0072559779509902,
0.009175372309982777,
0.02171245962381363,
-0.005996721796691418,
0.014045976102352142,
-0.00043165578972548246,
0.005256146192550659,
0.07366925477981567,
0.012636939994990826,
0.00926967803388834,
-0.021601513028144836,
-0.03477100282907486,
-0.019304895773530006,
0.02343214862048626,
0.013025256805121899,
0.026982475072145462,
0.015565958805382252,
-0.02542920783162117,
-0.014489766210317612,
-0.01894986256957054,
-0.02298835851252079,
-0.039608318358659744,
-0.019948391243815422,
0.014068164862692356,
0.014401008374989033,
-0.020469846203923225,
-0.013413573615252972,
0.01264803484082222,
0.0139350276440382,
0.011760453693568707,
0.004218785557895899,
-0.019205043092370033,
-0.009275225922465324,
-0.029090480878949165,
0.008720487356185913,
0.007017440628260374,
0.017851481214165688,
0.02112443745136261,
0.009130993857979774,
0.009646899998188019,
-0.026228031143546104,
0.03696776553988457,
0.031686656177043915,
0.004093969240784645,
-0.016309307888150215,
-0.03414969518780708,
0.03233015164732933,
0.020081529393792152,
-0.01098936703056097,
0.015111072920262814,
0.019804159179329872,
-0.00431031733751297,
-0.02098020538687706,
0.04415717348456383,
0.0186946839094162,
0.002539315028116107,
-0.0003318029048386961,
-0.009674637578427792,
0.004080100916326046,
-0.002554570324718952,
0.00789947435259819,
-0.005791468545794487,
-0.019504601135849953,
-0.014412103220820427,
0.019926201552152634,
-0.03073250688612461,
0.004726370796561241,
-0.0004597394145093858,
-0.024830089882016182,
0.014234586618840694,
0.00036578060826286674,
-0.04699743539094925,
-0.06834376603364944,
0.006751166190952063,
0.006734523922204971,
-0.015477200970053673,
-0.01938255876302719,
-0.028358226642012596,
0.003963605500757694,
0.026472115889191628,
-0.030244335532188416,
0.010118427686393261,
0.046775538474321365,
0.012903214432299137,
-0.003272956470027566,
-0.0037833156529814005,
0.03539230674505234,
0.011926875449717045,
-0.011638411320745945,
-0.0451778918504715,
-0.023387769237160683,
0.004185501020401716,
0.039608318358659744,
-0.01939365454018116,
0.034682244062423706,
0.015077789314091206,
-0.015099979005753994,
0.028114140033721924,
-0.007067366968840361,
-0.018151039257645607,
0.039164528250694275,
-0.00783845316618681,
-0.00877596065402031,
-0.01810665987432003,
0.024319730699062347,
-0.02542920783162117,
0.0142234917730093,
0.022489093244075775,
-0.012126580812036991,
0.0010477621108293533,
-0.018572641536593437,
0.01171607431024313,
-0.008953477256000042,
-0.0035336834844201803,
0.018750157207250595,
0.047929394990205765,
0.021623702719807625,
-0.003306240774691105,
0.019038621336221695,
-0.0016683756839483976,
-0.019182853400707245,
-0.004845639690756798,
0.0076886736787855625,
-0.02427535131573677,
0.015000125393271446,
-0.005322714801877737,
0.011893590912222862,
0.005167387891560793,
0.0163869708776474,
0.013502332381904125,
-0.035281360149383545,
-0.013347005471587181,
0.001175351906567812,
-0.025673292577266693,
0.005306072533130646,
-0.025495775043964386,
-0.0042742593213915825,
-0.01299197319895029,
-0.008293339051306248,
-0.01582113839685917,
0.020381087437272072,
-0.02718218043446541,
-0.0026003362145274878,
0.007333641406148672,
-0.014700567349791527,
-0.00825450662523508,
0.015255304984748363,
-0.015987560153007507,
0.004767976235598326,
-0.01896095834672451,
-0.01171607431024313,
-0.020625172182917595,
-0.01623164489865303,
0.0030732506420463324,
-0.0010630174074321985,
-0.03690119832754135,
0.017141416668891907,
0.0023548644967377186,
-0.01407925970852375,
0.020580794662237167,
0.01596537046134472,
0.004207690712064505,
0.021035678684711456,
-0.03301802650094032,
0.009253036230802536,
0.010756377130746841,
0.026272408664226532,
0.005333809647709131,
-0.021368522197008133,
0.010662071406841278,
-0.007999327033758163,
-0.03761126101016998,
-0.0169638991355896,
-0.025762049481272697,
-0.008809245191514492,
-0.00506753521040082,
0.0045294389128685,
-0.018328556790947914,
0.009291867725551128,
-0.002408951288089156,
0.03288489207625389,
-0.044490016996860504,
0.012403950095176697,
-0.006479344330728054,
-0.019726496189832687,
0.028114140033721924,
0.04788501560688019,
-0.011238999664783478,
0.0028763185255229473,
-0.01739659532904625,
0.021435091271996498,
-0.03490413725376129,
-0.013502332381904125,
-0.011494179256260395,
0.0009291867609135807,
-0.017740532755851746,
0.05933481827378273,
0.015854422003030777,
-0.042448580265045166,
-0.01737440563738346,
-0.027359696105122566,
-0.017563017085194588,
0.011105862446129322,
-0.04495599865913391,
0.0068898508325219154,
0.019615549594163895,
0.0156658124178648,
-0.0025601175148040056,
0.033839039504528046,
-0.02846917323768139,
0.015344063751399517,
-0.005111914128065109,
-0.019571170210838318,
-0.014589618891477585,
-0.014767135493457317,
-0.020358897745609283,
-0.026538683101534843,
-0.009541500359773636,
0.014789325185120106,
0.04051809012889862,
0.019160663709044456,
0.008759318850934505,
0.010978272184729576,
-0.01856154575943947,
-0.020791593939065933,
0.020469846203923225,
-0.005331035703420639,
0.0049870978109538555,
0.02831384725868702,
0.01956007443368435,
0.005325488280504942,
0.01486698817461729,
-0.00005239677193458192,
-0.011727169156074524,
-0.002554570324718952,
-0.02516293339431286,
-0.003589157247915864,
-0.037700019776821136,
-0.000313253840431571,
0.09363983571529388,
-0.00947493128478527,
-0.0036141204182058573,
0.017019374296069145,
-0.00524227786809206,
-0.015632526949048042,
0.0373893678188324,
0.0017391048604622483,
0.030199958011507988,
-0.010190543718636036,
0.021080058068037033,
0.02773691900074482,
0.04025181755423546,
0.025340449064970016,
0.021801218390464783,
-0.009524857625365257,
0.010451271198689938,
0.03838789463043213,
-0.014090354554355145,
-0.008426476269960403,
-0.0005332422442734241,
0.020436562597751617,
-0.009608068503439426,
0.03434940055012703,
-0.03545887768268585,
0.004263164475560188,
0.006679050158709288,
-0.004174406174570322,
-0.004465643782168627,
-0.01372422743588686,
0.010451271198689938,
0.013502332381904125,
0.0011455347994342446,
-0.011233451776206493,
0.0097079211845994,
-0.032418910413980484,
-0.02414221502840519,
-0.004976003430783749,
0.019637739285826683,
0.01579894870519638,
-0.006662407889962196,
0.0069675138220191,
-0.008759318850934505,
0.026228031143546104,
-0.0018888841150328517,
0.00827114935964346,
-0.02343214862048626,
0.020614078268408775,
0.01258146669715643,
-0.013236057944595814,
-0.000504118506796658,
-0.023920318111777306,
-0.008909097872674465,
-0.011261189356446266,
-0.035281360149383545,
-0.013324815779924393,
-0.011460894718766212,
-0.026272408664226532,
0.004926076624542475,
-0.014977935701608658,
-0.016719814389944077,
0.02400907687842846,
0.020292330533266068,
-0.018594831228256226,
0.0010900609195232391
] | 2024-07-04 | 30 | 38963636 | [
"CAR)-T cell therapy",
"target antigen expression",
"target antigen characteristics",
"leukemic cells",
"AML",
"hematopoietic stem cell transplantation",
"various targets",
"target",
"AML-targeted CAR-T cell therapy development",
"CAR-T cells",
"AML-targeting CAR-T cells",
"several clinical trials",
"Chimeric antigen receptor",
"AML-targeted CAR-T therapy",
"treatment",
"acute myeloid leukemia",
"promising results",
"development",
"on-/off-target tumor effects",
"no CAR-T cell products",
"patients",
"tumor",
"hematological malignancies",
"practical use",
"most cases",
"autologous lymphocytes",
"the ideal target",
"CLL-1",
"the current treatment strategy",
"the only curative treatment"
] | [
"AML",
"CD123",
"CLL-1",
"Chimeric antigen receptor",
"Clinical trials"
] | 0 | 10.1007/s12185-024-03809-w
10.1182/blood.2019001239
10.1056/NEJMoa1709866
10.1056/NEJMoa1817226
10.1200/JCO.20.03585
10.1056/NEJMoa1609783
10.1002/cncr.32116
10.3390/cancers15102713
10.1111/ejh.14047
10.1038/mt.2013.154
10.1038/mt.2014.164
10.1038/s41375-021-01232-2
10.1182/blood-2022-169142
10.1182/blood-2023-179667
10.1093/immadv/ltab018
10.1158/2326-6066.CIR-18-0307
10.1016/S2352-3026(22)00378-7
10.3324/haematol.2017.186742
10.1182/blood-2023-173582
10.1182/blood-2012-12-474056
10.1182/blood.V126.23.3778.3778
10.1182/blood.V130.Suppl_1.811.811
10.3389/fonc.2019.01358
10.1182/blood-2022-170201
10.1182/blood-2022-169928
10.1080/21645515.2023.2275457
10.1016/j.omto.2020.04.009
10.1182/blood.2020009759
10.1182/blood-2022-168877
10.1182/blood-2023-177867
10.1016/j.ymthe.2017.05.024
10.1182/blood-2018-99-110579
10.1158/1078-0432.CCR-20-4543
10.1038/s41375-022-01703-0
10.1186/s13045-022-01308-1
10.1182/blood-2023-180387
10.1002/cam4.5916
10.1182/blood-2023-179086
10.1056/NEJMoa2300709
10.1186/s13045-016-0256-3
10.1002/cti2.1282
10.1016/j.ccell.2023.09.010 | [
"Saito",
"Nakazawa"
] | [
"Department of Pediatrics, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan. [email protected].\nCenter for Advanced Research of Gene and Cell Therapy, Shinshu University, Matsumoto, Japan. [email protected].",
"Department of Pediatrics, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan.\nCenter for Advanced Research of Gene and Cell Therapy, Shinshu University, Matsumoto, Japan."
] | [
"38963636",
"31765470",
"29385370",
"31042825",
"34882493",
"28249141",
"30920645",
"37345050",
"37455578",
"23831595",
"25174587",
"33833386",
"34604863",
"30396908",
"36764323",
"29703727",
"24030378",
"31850234",
"37968136",
"32462078",
"33624009",
"28676343",
"33832948",
"36151140",
"35799191",
"35261791",
"37031462",
"37314354",
"26983639",
"37802054"
] | [] | 6.837687 | 7.178556 |
38963234 | 765 | Non-industrial production of therapeutic lentiviral vectors: How to provide vectors to academic CAR-T. | Bringing effective cancer therapy in the form of chimeric antigen receptor technology to untapped markets faces numerous challenges, including a global shortage of therapeutic lentiviral or retroviral vectors on which all current clinical therapies using genetically modified T cells are based. Production of these lentiviral vectors in academic settings in principle opens the way to local production of therapeutic cells, which is the only economically viable approach to make this therapy available to patients in developing countries. The conditions for obtaining and concentrating lentiviral vectors have been optimized and described. The calcium phosphate precipitation method was found to be suitable for transfecting high cell-density cultures, a prerequisite for high titers. We describe protocols for gradually increasing production from 6-well plates to P100 plates, T-175 flasks, and 5-layer stacks while maintaining high titers, >10 | [
0.009739951230585575,
-0.010212153196334839,
0.05575760081410408,
0.03553476929664612,
-0.005008488427847624,
-0.008021136745810509,
0.034048907458782196,
0.03344448655843735,
-0.023773793131113052,
-0.02679588459432125,
0.013599415309727192,
-0.005738827399909496,
-0.00404834421351552,
0.009475518018007278,
-0.005238293204456568,
-0.03797762468457222,
0.0365421324968338,
-0.02484411746263504,
-0.026216650381684303,
0.03178233653306961,
0.056059811264276505,
0.01959323137998581,
0.0028158973436802626,
-0.0164326261729002,
-0.022564955055713654,
-0.01984507218003273,
0.03679397329688072,
0.012629827484488487,
-0.024441171437501907,
-0.023572320118546486,
-0.01741480641067028,
-0.022690875455737114,
-0.03311709314584732,
0.014783067628741264,
-0.03943830356001854,
0.02765214443206787,
0.04208263382315636,
0.03734802454710007,
-0.004359997808933258,
0.014908988028764725,
0.06804744154214859,
-0.0024019337724894285,
0.031203102320432663,
0.0645720362663269,
-0.0022760131396353245,
0.01229613833129406,
-0.015865985304117203,
-0.022350890561938286,
-0.023786384612321854,
-0.009853280149400234,
-0.008531115017831326,
-0.0004934510216116905,
-0.0304475799202919,
0.011169149540364742,
-0.04782461002469063,
0.010035865008831024,
-0.02227533794939518,
0.019819889217615128,
-0.021494630724191666,
-0.006103996653109789,
0.029994266107678413,
0.003730395110324025,
0.043039631098508835,
-0.048277925699949265,
-0.015991905704140663,
0.0100547531619668,
-0.05490134283900261,
-0.016105232760310173,
-0.00974624790251255,
0.05031783506274223,
-0.007504862267524004,
-0.04125155881047249,
0.035131823271512985,
-0.019870257005095482,
-0.032688964158296585,
0.006264545489102602,
-0.03493034839630127,
0.05062004551291466,
0.03739839047193527,
-0.004457585979253054,
0.006850075908005238,
-0.04696835204958916,
0.044248469173908234,
-0.0016527067637071013,
-0.030951261520385742,
-0.04185597598552704,
0.035962898284196854,
0.006129181012511253,
-0.03178233653306961,
-0.009481814689934254,
-0.021393895149230957,
0.020386530086398125,
-0.042913708835840225,
0.04465141147375107,
-0.006173253059387207,
0.0510985441505909,
0.006041036453098059,
-0.01405272912234068,
0.021482039242982864,
0.030749788507819176,
0.07172432541847229,
-0.002930799964815378,
-0.002584518399089575,
0.0026396086905151606,
0.026468491181731224,
-0.008839620277285576,
-0.031958624720573425,
-0.012126144953072071,
0.027727697044610977,
0.022867165505886078,
0.06311135739088058,
-0.047673504799604416,
0.01715037412941456,
0.036088816821575165,
-0.0043096295557916164,
-0.039035357534885406,
-0.029415031895041466,
-0.00529180932790041,
0.010942492634057999,
0.06512609124183655,
-0.030623868107795715,
0.03271414712071419,
0.042309291660785675,
-0.028886165469884872,
0.02202349714934826,
-0.028155826032161713,
0.053742874413728714,
-0.005455506034195423,
-0.00023472370230592787,
-0.06401798874139786,
0.053893979638814926,
-0.0037398391868919134,
0.04477733373641968,
-0.04296407848596573,
-0.042913708835840225,
-0.014506042934954166,
-0.026997357606887817,
0.05079633370041847,
-0.008367418311536312,
0.012384282425045967,
0.01983248069882393,
0.0015126201324164867,
-0.010929900221526623,
-0.00410815654322505,
0.005949744023382664,
-0.030397212132811546,
-0.023534543812274933,
0.028558772057294846,
0.034779246896505356,
0.04031974822282791,
-0.033167462795972824,
0.0021123166661709547,
0.0231315977871418,
0.011975040659308434,
-0.01886289194226265,
-0.03911091014742851,
-0.012415762059390545,
0.06432019919157028,
-0.005748271476477385,
-0.02264050766825676,
-0.006078812759369612,
0.013347574509680271,
-0.033419303596019745,
-0.0487312376499176,
0.011515431106090546,
-0.021028725430369377,
-0.0176666472107172,
0.004907751921564341,
-0.07419236749410629,
-0.008921468630433083,
-0.03200899437069893,
-0.045356567949056625,
-0.06517645716667175,
-0.019039181992411613,
-0.019996177405118942,
-0.030623868107795715,
0.0007964472169987857,
0.053138457238674164,
-0.021028725430369377,
-0.008619259111583233,
-0.009167012758553028,
0.030850525945425034,
0.022061273455619812,
0.001610995503142476,
-0.017377030104398727,
0.033922985196113586,
-0.011893192306160927,
0.0062834336422383785,
-0.011483950540423393,
-0.04890752583742142,
-0.0029969082679599524,
-0.03158086538314819,
0.019769519567489624,
0.015324526466429234,
0.01181134395301342,
0.02400044910609722,
0.05197998508810997,
0.0401938259601593,
0.035383664071559906,
-0.03472887724637985,
-0.022476810961961746,
-0.020726516842842102,
-0.048756420612335205,
-0.027198830619454384,
-0.011005452834069729,
-0.06804744154214859,
-0.018182922154664993,
0.04238484427332878,
0.023119006305933,
-0.006019000429660082,
0.03248749300837517,
0.024063410237431526,
-0.007712631486356258,
0.014720107428729534,
-0.007624486926943064,
0.010715835727751255,
-0.018699195235967636,
0.08084096759557724,
0.015865985304117203,
-0.00018081397865898907,
-0.037902072072029114,
-0.0016479847254231572,
-0.020021360367536545,
0.033066727221012115,
-0.012535386718809605,
-0.02509595826268196,
-0.014229017309844494,
-0.04223373904824257,
0.022086458280682564,
-0.03747394308447838,
0.014846027828752995,
-0.01169171929359436,
0.0039129797369241714,
-0.04684242978692055,
-0.01741480641067028,
-0.005376806017011404,
0.031983811408281326,
0.026594411581754684,
0.018585868179798126,
-0.03193344175815582,
0.022187193855643272,
-0.0018085333285853267,
0.0015976164722815156,
-0.015525998547673225,
-0.021859800443053246,
-0.004772387444972992,
-0.02193535305559635,
-0.08340974897146225,
0.015047500841319561,
-0.0021910169161856174,
-0.012711675837635994,
-0.013498678803443909,
-0.007863735780119896,
-0.004857383668422699,
0.021582774817943573,
-0.004325369372963905,
-0.011106189340353012,
-0.045457303524017334,
0.019580639898777008,
0.005808083340525627,
0.0054964302107691765,
0.021217606961727142,
-0.0621039941906929,
0.012510202825069427,
-0.04246039688587189,
0.009286637417972088,
-0.026367755606770515,
0.032059360295534134,
0.008839620277285576,
0.006862667854875326,
0.021494630724191666,
-0.011049524880945683,
0.06638529151678085,
-0.04147821664810181,
-0.06104626506567001,
-0.027828432619571686,
0.0020115801598876715,
0.03545921668410301,
-0.009343301877379417,
0.05439766123890877,
-0.055455394089221954,
0.020361347123980522,
-0.013536455109715462,
-0.005342177581042051,
0.0002650233218446374,
-0.011358030140399933,
0.05208072438836098,
-0.019681375473737717,
-0.002830063458532095,
-0.032814886420965195,
0.04563359171152115,
-0.007145989220589399,
-0.0042120409198105335,
-0.03178233653306961,
0.007756703533232212,
0.02230052277445793,
-0.006019000429660082,
0.0316312313079834,
-0.02981797605752945,
-0.015979312360286713,
-0.013926808722317219,
0.009639214724302292,
0.011981336399912834,
-0.026493676006793976,
-0.02348417602479458,
0.009488110430538654,
-0.025864072144031525,
-0.04638911783695221,
0.022111641243100166,
0.04674169421195984,
0.03623992204666138,
0.02094058133661747,
0.015916353091597557,
-0.010791387408971786,
-0.011219517327845097,
0.051451120525598526,
0.0037429872900247574,
-0.06421945989131927,
0.00035631569335237145,
-0.018900668248534203,
-0.038909438997507095,
-0.009148125536739826,
0.005871044006198645,
-0.01606745645403862,
0.02262791618704796,
-0.033520039170980453,
0.03203417733311653,
-0.016961492598056793,
0.06588160991668701,
0.006261397618800402,
-0.00003625133467721753,
-0.029012085869908333,
0.05187924951314926,
-0.013360165990889072,
-0.024126369506120682,
-0.010331777855753899,
0.010256225243210793,
-0.05908190459012985,
0.045835066586732864,
0.005102928727865219,
-0.006299173459410667,
0.0100547531619668,
0.007769295480102301,
0.07247984409332275,
0.001998988213017583,
-0.0028820056468248367,
0.01584080047905445,
0.021998312324285507,
0.013800888322293758,
0.06175141781568527,
0.01125729363411665,
0.03739839047193527,
0.02446635439991951,
0.010533250868320465,
0.016848163679242134,
-0.0022130529396235943,
0.033545225858688354,
-0.0030913485679775476,
-0.031354207545518875,
0.000328180321957916,
0.008871099911630154,
0.025259654968976974,
-0.021847208961844444,
0.021142054349184036,
0.007234133314341307,
0.07242947816848755,
0.004813311621546745,
0.046187642961740494,
-0.013372758403420448,
-0.049234919250011444,
-0.0048699756152927876,
-0.01137691829353571,
-0.015450446866452694,
0.005562538746744394,
-0.013057957403361797,
0.0020729664247483015,
0.04578469693660736,
0.00974624790251255,
0.04105008766055107,
0.024642644450068474,
0.02400044910609722,
-0.02604036219418049,
-0.04442475736141205,
-0.005128112621605396,
-0.01273056399077177,
0.03263859823346138,
0.030145369470119476,
-0.025914441794157028,
-0.09444038569927216,
0.010627690702676773,
0.009355894289910793,
-0.01509786956012249,
0.012371690012514591,
-0.002474338049069047,
-0.002260273089632392,
0.004369441885501146,
-0.0596863217651844,
0.06527719646692276,
0.03629029169678688,
0.0071333968080580235,
0.015274157747626305,
-0.03543402999639511,
-0.03984124958515167,
-0.0075300466269254684,
0.041226375848054886,
-0.021847208961844444,
0.00044819831964559853,
0.018359210342168808,
-0.005213109310716391,
-0.023333070799708366,
-0.011005452834069729,
0.004561470355838537,
0.020248018205165863,
0.02616628259420395,
0.03417482599616051,
-0.0014520208351314068,
0.0017770532285794616,
0.015576367266476154,
-0.012673899531364441,
0.016268929466605186,
-0.026695149019360542,
-0.04759795218706131,
-0.022741245105862617,
0.017100004479289055,
-0.0008625555201433599,
-0.004762943368405104,
0.021519815549254417,
0.021960537880659103,
-0.06175141781568527,
-0.022791612893342972,
-0.027727697044610977,
0.002584518399089575,
-0.016344482079148293,
-0.007769295480102301,
0.005556242540478706,
0.06719118356704712,
-0.007045252714306116,
-0.02644330821931362,
-0.006554162595421076,
-0.0011679127346724272,
-0.015916353091597557,
0.053742874413728714,
-0.03150531277060509,
-0.04714464023709297,
-0.0067745232954621315,
0.04301444813609123,
-0.004892011638730764,
0.04175524041056633,
-0.020902805030345917,
-0.017238518223166466,
0.000028233738703420386,
-0.033771879971027374,
0.023081229999661446,
-0.017389623448252678,
-0.02750103920698166,
-0.040596771985292435,
0.023534543812274933,
-0.04276260733604431,
-0.00239091576077044,
-0.008298161439597607,
0.03115273453295231,
0.005087188445031643,
-0.013095732778310776,
-0.013951992616057396,
0.0030944966711103916,
0.06804744154214859,
0.040344931185245514,
-0.021507224068045616,
0.00851852260529995,
-0.024038225412368774,
-0.007788183633238077,
-0.04082342982292175,
-0.030372027307748795,
-0.012969812378287315,
-0.03359559178352356,
0.07011254131793976,
-0.008719995617866516,
-0.025662600994110107,
-0.014128281734883785,
0.01325942948460579,
-0.007013772614300251,
-0.016155602410435677,
-0.042661868035793304,
-0.004183709155768156,
-0.0050273765809834,
0.03588734567165375,
0.014077913016080856,
-0.00684377970173955,
-0.01193096861243248,
-0.012352801859378815,
0.04533138498663902,
-0.014354938641190529,
-0.01681038737297058,
-0.012743155471980572,
0.020386530086398125,
0.013763112016022205,
-0.030523132532835007,
0.017968857660889626,
-0.011238405480980873,
0.009488110430538654,
0.005043116398155689,
0.06064331904053688,
-0.03576142340898514,
0.006472314242273569,
0.050846703350543976,
0.002321659354493022,
0.04117600619792938,
0.0353332944214344,
-0.023685647174715996,
0.04830310866236687,
-0.0389598049223423,
-0.015538590960204601,
-0.020739108324050903,
-0.021721288561820984,
-0.005147000774741173,
0.009739951230585575,
-0.03971532732248306,
0.0073537579737603664,
-0.023773793131113052,
-0.01655854657292366,
0.011062117293477058,
-0.028760245069861412,
-0.03591252863407135,
0.03357040882110596,
-0.04512991011142731,
0.01497194916009903,
-0.027224013581871986,
-0.016974084079265594,
-0.01912732608616352,
-0.02933947928249836,
0.03603845089673996,
-0.013561639003455639,
-0.026367755606770515,
0.009607735089957714,
-0.03639102727174759,
0.011641351506114006,
-0.023584911599755287,
0.009588846936821938,
-0.018585868179798126,
-0.029314294457435608,
-0.016722243279218674,
0.011213221587240696,
-0.005147000774741173,
-0.010848051868379116,
-0.028029905632138252,
-0.009897352196276188,
0.021607959643006325,
0.0008373713935725391,
-0.012100961059331894,
-0.003777615260332823,
0.02666996419429779,
-0.03702063113451004,
0.0011781437788158655,
-0.04349294304847717,
0.020499859005212784,
0.016029680147767067,
-0.014468266628682613,
-0.02410118654370308,
-0.0006410140777006745,
-0.026997357606887817,
-0.014518635347485542,
0.003425037954002619,
0.019542863592505455,
-0.02217460237443447,
-0.0008129742927849293,
0.013473494909703732,
-0.007599303033202887,
-0.01138950977474451,
-0.026846252381801605,
0.003248749068006873,
-0.03664286807179451,
-0.027299566194415092,
0.004970712121576071,
-0.04067232459783554,
0.03150531277060509,
0.0340992733836174,
-0.006261397618800402,
-0.008594075217843056,
-0.003812243463471532,
0.018321434035897255,
0.007120804861187935,
-0.006343245506286621,
-0.03213491290807724,
0.021872391924262047,
-0.0034187419805675745,
-0.009972904808819294,
-0.012680195271968842,
0.004744055215269327,
-0.010407330468297005,
0.02081466093659401,
0.04550767317414284,
0.032336387783288956,
0.0017203890020027757,
0.011546910740435123,
-0.024302657693624496,
0.0004906965186819434,
0.008058913052082062,
-0.02202349714934826,
-0.016117826104164124,
-0.04419809952378273,
-0.014908988028764725,
0.021104278042912483,
-0.001460677944123745,
-0.04210782051086426,
-0.030523132532835007,
0.024982629343867302,
-0.01985766366124153,
-0.02140648663043976,
-0.0025561864022165537,
-0.0267706997692585,
0.021859800443053246,
0.013460902497172356,
-0.024982629343867302,
-0.007259317673742771,
0.035988081246614456,
0.005899375770241022,
0.001577941351570189,
-0.014090505428612232,
0.012881668284535408,
-0.027475856244564056,
-0.015299341641366482,
-0.00027053235680796206,
-0.008021136745810509,
-0.0103380735963583,
-0.005480690393596888,
-0.005074596498161554,
-0.010262521915137768,
-0.022841980680823326,
-0.013737928122282028,
-0.01180504821240902,
0.006573050748556852,
-0.03324301540851593,
-0.0003777615202125162,
0.011716903187334538,
-0.023282703012228012,
-0.02664477936923504,
0.007838551886379719,
-0.022212378680706024,
0.02104131691157818,
-0.017994040623307228,
-0.0031212547328323126,
0.0328652523458004,
-0.01776738464832306,
-0.03588734567165375,
-0.003198381047695875,
-0.021469447761774063,
-0.037927258759737015,
-0.024806341156363487,
0.030397212132811546,
-0.007007476408034563,
0.01961841620504856,
-0.0017943673301488161,
0.010992860421538353,
-0.028936533257365227,
0.0036926190368831158,
-0.009236269630491734,
0.0039885323494672775,
-0.009777727536857128,
0.051577042788267136,
0.06537792831659317,
0.0050525604747235775,
0.02823137864470482,
0.02604036219418049,
-0.00045724885421805084,
-0.004778683185577393,
-0.03324301540851593,
0.00490460405126214,
0.033771879971027374,
-0.02119242213666439,
0.00614806916564703,
0.06013963744044304,
0.03276451677083969,
0.011660239659249783,
-0.030019449070096016,
-0.01175467949360609,
-0.012686491012573242,
-0.018913261592388153,
-0.03636584430932999,
0.021393895149230957,
0.00571993924677372,
0.006289729382842779,
0.011956152506172657,
-0.05243330076336861,
-0.0023137894459068775,
0.029314294457435608,
-0.017717014998197556,
-0.005679015070199966,
0.02567519247531891,
-0.022829389199614525,
-0.0017975153168663383,
-0.002866265596821904,
0.0029890381265431643,
0.009714767336845398,
-0.0018604755168780684,
0.024617459625005722,
0.00863814726471901,
-0.019064364954829216,
0.0006610826821997762,
0.022224970161914825,
-0.020008768886327744,
-0.0004918769700452685,
0.013347574509680271,
0.04555803909897804,
-0.02518410235643387,
-0.00351318228058517,
0.00028233739431016147,
-0.03969014436006546,
-0.011452470906078815,
0.02046208269894123,
0.024189330637454987,
0.009790319949388504,
0.0011742087081074715,
-0.02777806483209133,
-0.022942716255784035,
-0.010231041349470615,
0.01983248069882393,
-0.0030803305562585592,
0.0340740904211998,
0.013964585028588772,
0.00796447228640318,
0.018057001754641533,
0.010753612034022808,
-0.027803249657154083,
0.008008544333279133,
-0.0008436674252152443,
0.03251267597079277,
-0.024755973368883133,
0.05223182961344719,
-0.007038956508040428,
-0.010659171268343925,
-0.010514362715184689,
0.01970656029880047,
0.019668783992528915,
-0.030850525945425034,
-0.01338534988462925,
0.017490359023213387,
-0.021494630724191666,
-0.013297205790877342,
-0.007246725261211395,
-0.009595142677426338,
0.02459227666258812,
-0.06170105189085007,
-0.015626735985279083,
0.025599639862775803,
-0.020046545192599297,
0.028659507632255554,
0.04127674177289009,
0.01788071170449257,
0.01851031556725502,
-0.04847939684987068,
-0.019568046554923058,
0.010124009102582932,
-0.03603845089673996,
-0.014531226828694344,
0.013133509084582329,
-0.04772387444972992,
-0.002623868640512228,
-0.020726516842842102,
-0.013737928122282028,
-0.042913708835840225,
-0.027450671419501305,
-0.011024340987205505,
0.005008488427847624,
-0.017364438623189926,
0.004038900602608919,
0.00956366304308176,
-0.0005115520907565951,
-0.004592950455844402,
-0.013586822897195816,
0.007870031520724297,
-0.04711945354938507,
-0.0007877902244217694,
0.035383664071559906,
-0.0024334138724952936,
0.02908763848245144,
0.021217606961727142,
-0.022501995787024498,
0.013523862697184086,
0.007290797773748636,
-0.0014370678691193461,
-0.013423126190900803,
-0.005203665234148502,
-0.032940804958343506,
0.010986564680933952,
-0.01728888601064682,
0.0017786271637305617,
-0.002469616010785103,
0.05092225596308708,
-0.012617235071957111,
-0.006799707654863596,
-0.027425486594438553,
0.013700151816010475,
-0.012787227518856525,
0.04817718639969826,
-0.019064364954829216,
0.005531058646738529,
0.03639102727174759,
-0.08693552017211914,
-0.020260609686374664,
0.0019360278965905309,
-0.00045724885421805084,
-0.016898533329367638,
0.010010680183768272,
-0.022501995787024498,
0.020877620205283165,
0.023219741880893707,
-0.012226881459355354,
0.01740221492946148,
-0.01485862024128437,
0.04185597598552704,
0.01273056399077177,
0.0036044747103005648,
0.01995840109884739,
-0.03102681413292885,
-0.0596863217651844,
-0.0057640112936496735,
0.006824891548603773,
-0.03153049573302269,
0.034779246896505356,
0.013599415309727192,
0.03545921668410301,
0.01248501893132925,
-0.0143045699223876,
-0.008512226864695549,
0.0017188149504363537,
-0.040370114147663116,
-0.02704772539436817,
-0.000980605953373015,
0.021217606961727142,
-0.021884985268115997,
0.04160413518548012,
-0.022476810961961746,
-0.02058800309896469,
0.02105391025543213,
0.012837596237659454,
0.02167092077434063,
0.0009625048842281103,
0.0075300466269254684,
-0.009532182477414608,
0.05140075087547302,
0.01606745645403862,
-0.022841980680823326,
0.004155376926064491,
-0.012440946884453297,
-0.024932261556386948,
0.009947719983756542,
-0.02619146555662155,
0.046691324561834335,
-0.02641812339425087,
-0.024126369506120682,
0.001104165450669825,
0.015677103772759438,
-0.006302321795374155,
-0.00034824892645701766,
0.012875372543931007,
0.004958120174705982,
-0.0046999831683933735,
-0.007328573614358902,
0.01681038737297058,
0.04530619829893112,
-0.02094058133661747,
-0.01679779589176178,
-0.005392545834183693,
-0.012762043625116348,
0.05555612966418266,
-0.04253594949841499,
0.0292135588824749,
-0.02033616229891777,
0.008789251558482647,
-0.04898307844996452,
0.0450543574988842,
0.0026065546553581953,
0.03069942072033882,
0.0053579178638756275,
0.03273933380842209,
0.010205857455730438,
-0.019026588648557663,
-0.045734331011772156,
-0.009236269630491734,
-0.0009931980166584253,
-0.009047389030456543,
-0.015639327466487885,
0.01332238968461752,
0.01633189059793949,
-0.013561639003455639,
0.006188993342220783,
0.023421214893460274,
0.012686491012573242,
-0.009525886736810207,
-0.013423126190900803,
0.00895294826477766,
0.036592502146959305,
-0.008159649558365345,
-0.025587048381567,
-0.007788183633238077,
-0.002150092739611864,
-0.030044633895158768,
0.03883388638496399,
-0.025637416169047356,
0.005502726417034864,
-0.0668889731168747,
-0.012264657765626907,
-0.010180673561990261,
0.048655685037374496,
-0.03238675370812416,
0.0021012984216213226,
-0.00020816233882214874,
0.030170554295182228,
-0.005650682840496302,
0.03923683241009712,
-0.02619146555662155,
0.016722243279218674,
0.019215470179915428,
0.02933947928249836,
0.04603653773665428,
0.0219101682305336,
0.001164764747954905,
0.06270841509103775,
0.014757883735001087,
-0.03142976015806198,
-0.030472762882709503,
-0.0024869299959391356,
-0.021947944536805153,
0.015601551160216331,
0.019454719498753548,
0.007108212914317846,
-0.020021360367536545,
0.0024035077076405287,
0.01824588142335415,
0.02214941754937172,
-0.014166057109832764,
-0.017591094598174095,
0.020424306392669678,
0.01935398206114769,
0.008165945298969746,
-0.006617122795432806,
-0.01571488007903099,
0.02352195233106613,
-0.024680420756340027,
-0.01143987849354744,
-0.005392545834183693,
0.03553476929664612,
0.008908876217901707,
-0.06381651759147644,
0.03714654967188835,
-0.034048907458782196,
0.0032613412477076054,
0.0025530382990837097,
0.03142976015806198,
-0.0044103660620749,
0.0656801387667656,
-0.005288661457598209,
0.02750103920698166,
0.045482490211725235,
0.013410534709692001,
0.002504244213923812,
0.010419921949505806,
0.017553318291902542,
0.030472762882709503,
-0.00796447228640318,
-0.01862364448606968,
0.025650007650256157,
-0.0069948844611644745,
-0.010356961749494076,
-0.0024601719342172146,
0.05933374539017677,
0.0037461351603269577,
0.016722243279218674,
-0.05611018091440201,
0.02664477936923504,
-0.01393940020352602,
-0.0523829311132431,
0.0020100062247365713,
0.04613727703690529,
0.05243330076336861,
0.014417898841202259,
0.008631850592792034,
-0.02641812339425087,
0.01727629452943802,
-0.003163752844557166,
0.04336702451109886,
0.04314036667346954,
-0.034048907458782196,
-0.015991905704140663,
-0.007693743333220482,
0.03623992204666138,
-0.01040103379637003,
-0.017868120223283768,
-0.015362302772700787,
0.02944021485745907,
0.045003991574048996,
0.029364662244915962,
-0.022086458280682564,
-0.02303086221218109,
0.00261599849909544,
-0.02933947928249836,
-0.027576591819524765,
-0.020122097805142403,
0.008682219311594963,
0.023421214893460274,
-0.0025420202873647213,
-0.025511495769023895,
0.03188307210803032,
0.02629220299422741,
-0.03430074825882912,
-0.005335881840437651,
0.013523862697184086,
0.018951036036014557,
0.042183369398117065,
-0.05505244806408882,
0.04361886531114578,
0.0136875594034791,
-0.002538872417062521,
-0.005436617881059647,
0.009891056455671787,
-0.059233009815216064,
-0.03115273453295231,
-0.04429883509874344,
-0.022363482043147087,
-0.02554927207529545,
0.006472314242273569,
-0.011855415999889374,
0.019681375473737717,
0.04928528890013695,
-0.014694923534989357,
0.00733486982062459,
0.014354938641190529,
0.00172668497543782,
0.02654404379427433,
0.029918713495135307,
0.014266793616116047,
-0.013901624828577042,
-0.018422171473503113,
-0.003510034177452326,
-0.021998312324285507,
0.01143987849354744,
-0.01898881234228611,
0.04858013242483139,
0.01570228859782219,
0.015639327466487885,
-0.010193265043199062,
-0.0231315977871418,
0.014417898841202259,
0.03102681413292885,
-0.035836976021528244,
0.0042183371260762215,
-0.018535498529672623,
-0.013674967922270298,
0.00895294826477766,
0.00889628380537033,
0.01691112481057644,
0.05883006379008293,
0.029314294457435608,
0.0176540557295084,
0.02994389832019806,
0.01984507218003273,
-0.005760863423347473,
0.007838551886379719,
-0.021142054349184036,
0.027173645794391632,
0.003724099136888981,
0.029163191094994545,
-0.02193535305559635,
0.003931867890059948,
-0.013171285390853882,
0.012944628484547138,
0.038405757397413254,
0.017490359023213387,
0.006560458801686764,
-0.02568778395652771,
-0.0007220754050649703,
-0.002184720942750573,
-0.011553206481039524,
0.02570037543773651,
-0.028760245069861412,
-0.029163191094994545,
-0.015110461041331291,
-0.03132902458310127,
-0.012453538365662098,
-0.031480126082897186,
0.0013520715292543173,
0.02264050766825676,
0.01400236040353775,
-0.020638370886445045,
-0.012566867284476757,
-0.010791387408971786,
-0.028709877282381058,
0.006440834142267704,
0.010262521915137768,
-0.01848513074219227,
-0.0121828094124794,
-0.027198830619454384,
-0.01236539427191019,
-0.0029921862296760082,
-0.010413626208901405,
-0.004980156198143959,
0.02823137864470482,
0.025914441794157028,
0.024907076731324196,
0.00956366304308176,
-0.014468266628682613,
0.018951036036014557,
-0.016470402479171753,
-0.02654404379427433,
-0.050695598125457764,
0.03029647469520569,
-0.02447894774377346,
-0.011666535399854183,
0.030649052932858467,
0.003431333927437663,
-0.007813367992639542,
-0.0036611389368772507,
-0.008480746299028397,
-0.02651885896921158,
-0.0038940918166190386,
0.011188037693500519,
0.006617122795432806,
-0.02423969842493534,
-0.011880599893629551,
-0.006963404361158609,
-0.006963404361158609,
-0.030875708907842636,
-0.023761199787259102,
0.0034502220805734396,
0.016218561679124832,
-0.0082100173458457,
-0.0032896732445806265,
0.0486808679997921,
0.007983360439538956,
0.0009381077834405005,
0.0069948844611644745,
0.015311934053897858,
0.017691832035779953,
0.012384282425045967,
-0.04162932187318802,
0.022980492562055588,
0.004007420036941767,
-0.02338343858718872,
-0.001731407013721764,
-0.001337905414402485,
0.04601135477423668,
-0.020776884630322456,
0.02994389832019806,
-0.026569228619337082,
0.01937916688621044,
-0.02898690104484558,
0.02068874053657055,
0.058024171739816666,
0.0013552195159718394,
-0.02740030363202095,
0.06079442426562309,
0.01974433660507202,
0.0143045699223876,
-0.006850075908005238,
0.04603653773665428,
-0.0061165885999798775,
-0.016281522810459137,
-0.021469447761774063,
0.02520928718149662,
0.02533520758152008,
0.007366349920630455,
-0.0170496366918087,
0.02704772539436817,
-0.0007519815699197352,
-0.049511946737766266,
-0.018308842554688454,
-0.03566068783402443,
0.0013276743702590466,
0.015563774853944778,
-0.02898690104484558,
0.02060059644281864,
0.002592388540506363,
0.023093821480870247,
0.028055090457201004,
0.018170328810811043,
0.014077913016080856,
0.01995840109884739,
0.017225926741957664,
-0.011710607446730137,
-0.006251953542232513,
-0.043769970536231995,
0.008203721605241299,
-0.015261566266417503,
-0.03485479578375816,
-0.03188307210803032,
-0.008631850592792034,
-0.009595142677426338,
-0.015072684735059738,
0.019769519567489624,
-0.019580639898777008,
-0.016986677423119545,
-0.03054831549525261,
0.007914104498922825,
-0.01211355347186327,
-0.002405081642791629,
0.0038940918166190386,
-0.0188754852861166,
-0.009891056455671787,
0.008688515052199364,
0.021721288561820984,
-0.0008704255451448262,
-0.011055820621550083,
0.021343527361750603,
-0.004744055215269327,
0.015085277147591114,
0.009387373924255371,
0.010388442315161228,
-0.011603575199842453,
0.004633874632418156,
-0.041805610060691833,
0.03334375098347664,
-0.013460902497172356,
0.017502950504422188,
0.019945809617638588,
-0.0004674798983614892,
-0.04898307844996452,
0.0034502220805734396,
-0.004684242885559797,
-0.04009309038519859,
0.009488110430538654,
0.002622294705361128,
-0.022980492562055588,
-0.003092922503128648,
0.02644330821931362,
0.006170105189085007,
-0.03445185348391533,
0.00285996962338686,
-0.0018022373551502824,
-0.002619146602228284,
-0.01848513074219227,
-0.049965258687734604,
-0.030220922082662582,
0.02044949121773243,
0.014757883735001087,
0.02522187866270542,
-0.011307661421597004,
0.03472887724637985,
-0.013032772578299046,
-0.018963629379868507,
0.045482490211725235,
0.014770476147532463,
-0.02629220299422741,
-0.015324526466429234,
-0.016029680147767067,
-0.0024932262022048235,
0.03591252863407135,
0.02644330821931362,
-0.007441902067512274,
0.04759795218706131,
0.0048384955152869225,
0.0027875653468072414,
-0.024315251037478447,
0.03203417733311653,
-0.04130192846059799,
0.00863814726471901,
0.016760019585490227,
0.010086232796311378,
-0.03248749300837517,
-0.0024853560607880354,
-0.0019013996934518218,
0.03029647469520569,
0.008631850592792034,
0.018082184717059135,
-0.01959323137998581,
-0.003818539436906576,
-0.0020462083630263805,
0.01187430415302515,
0.002623868640512228,
0.022590139880776405,
-0.0003067344950977713,
0.00045567486085928977,
0.016709651798009872,
-0.020789476111531258,
0.051577042788267136,
-0.0019124177051708102,
0.003092922503128648,
-0.030649052932858467,
0.01679779589176178,
-0.005830119829624891,
0.021469447761774063,
0.007158581167459488,
0.017817752435803413,
0.026367755606770515,
-0.03432593122124672,
-0.02080206759274006,
0.03178233653306961,
0.002532576210796833,
-0.023761199787259102,
-0.010558434762060642,
0.013435718603432178,
0.0115595031529665,
0.006749339401721954,
0.01193096861243248,
-0.004448141902685165,
0.019693968817591667,
-0.03188307210803032,
-0.00913553312420845,
-0.0027041430585086346,
0.005871044006198645,
-0.006173253059387207,
0.01971915178000927,
0.009412557817995548,
-0.00031755579402670264,
-0.024781156331300735,
-0.047774240374565125,
0.01618078537285328,
-0.004054640419781208,
-0.007108212914317846,
-0.005241441074758768,
0.017112597823143005,
0.013511271215975285,
0.0364917628467083,
-0.06160031259059906,
-0.027450671419501305,
0.05187924951314926,
0.005628646817058325,
0.013133509084582329,
0.0182710662484169,
0.0425863154232502,
0.013297205790877342,
-0.03054831549525261,
0.014090505428612232,
-0.0077378153800964355,
-0.013334982097148895,
0.02157018333673477,
-0.02908763848245144,
-0.0006111079710535705,
0.028155826032161713,
0.008801843971014023,
0.0073474617674946785,
-0.01168542355298996,
-0.027098093181848526,
0.04359368234872818,
-0.043392207473516464,
-0.00590567197650671,
-0.029515767470002174,
-0.035610321909189224,
-0.008178536780178547,
0.009299229830503464,
-0.015601551160216331,
-0.011269886046648026,
0.025989992544054985,
-0.016608916223049164,
-0.000535162165760994,
-0.010382146574556828,
-0.006919331848621368,
0.012371690012514591,
-0.009305525571107864,
-0.00809039268642664,
-0.005156444851309061,
0.028835797682404518,
-0.016747428104281425,
-0.018069593235850334,
0.0034502220805734396,
-0.004825903568416834,
-0.010275113396346569,
0.019265837967395782,
0.03689470887184143,
-0.025058181956410408,
0.0036768789868801832,
0.01436753012239933,
0.00008096295641735196,
-0.030246106907725334,
0.00040019111474975944,
0.008191129192709923,
-0.0066360109485685825,
-0.013171285390853882,
-0.005153296981006861,
0.013397942297160625,
-0.020399123430252075,
0.02155759185552597,
-0.011307661421597004,
0.02422710694372654,
0.021091684699058533,
-0.01119433343410492,
-0.012881668284535408,
-0.015853391960263252,
-0.016974084079265594,
0.0020446341950446367,
-0.038531675934791565,
0.014506042934954166,
-0.01800663396716118,
-0.03906054422259331,
-0.0176540557295084,
0.001522064208984375,
0.021255381405353546,
0.007265613414347172,
-0.028029905632138252,
-0.0340740904211998,
0.022376075387001038,
0.004155376926064491,
0.029868345707654953,
0.018938444554805756,
0.020285794511437416,
0.01443049032241106,
-0.02593962475657463,
0.028760245069861412,
0.020990949124097824,
0.01138950977474451,
-0.015085277147591114,
-0.014128281734883785,
-0.013624599203467369,
-0.002474338049069047,
0.004545730538666248,
-0.029490584507584572,
-0.020915396511554718,
0.016508178785443306,
0.007989656180143356,
-0.020890213549137115,
0.005131260957568884,
-0.013775703497231007,
0.028659507632255554,
0.03346967324614525,
-0.034653324633836746,
0.0402190126478672,
-0.01064657885581255,
0.039513856172561646,
0.021255381405353546,
0.04842902719974518,
0.02944021485745907,
0.006787115707993507,
-0.007574118673801422,
0.03334375098347664,
-0.0017628871137276292,
-0.012762043625116348,
0.0474468469619751,
-0.007101916708052158,
-0.047421663999557495,
0.03029647469520569,
0.01838439516723156,
0.0018683455418795347,
-0.01961841620504856,
-0.005852155853062868,
-0.05243330076336861,
0.02217460237443447,
-0.020436899736523628,
-0.000923941726796329,
0.0003364438598509878,
0.009299229830503464,
0.012655011378228664,
0.008197424933314323,
-0.03140457719564438,
0.026317385956645012,
-0.013120917603373528,
-0.016948901116847992,
-0.0267706997692585,
0.007120804861187935,
0.003396705724298954,
0.015639327466487885,
0.0088207321241498,
0.049134183675050735,
0.008354825899004936,
0.006188993342220783,
0.004907751921564341,
0.010438810102641582,
-0.021947944536805153,
0.0027041430585086346,
0.024201922118663788,
-0.04920973628759384,
0.023698240518569946,
0.03142976015806198,
0.004696834832429886,
0.006975996308028698,
-0.016344482079148293,
-0.0024334138724952936,
-0.013586822897195816,
0.017251109704375267,
-0.032688964158296585,
0.018107369542121887,
-0.01606745645403862,
-0.00025105400709435344,
0.06900443881750107,
-0.036466579884290695,
-0.02315678261220455,
0.012655011378228664,
0.021469447761774063,
-0.030749788507819176,
0.040370114147663116,
-0.013146101497113705,
-0.0011104615405201912,
-0.0023011972662061453,
0.029062453657388687,
-0.040370114147663116,
0.040621958673000336,
0.0023972117342054844,
0.0006496711284853518,
-0.013360165990889072,
0.03092607669532299,
0.00937478244304657,
0.009928831830620766,
-0.04006790742278099,
-0.02714846283197403,
0.0015842374414205551,
-0.03130383789539337,
0.025385575369000435,
-0.01934139057993889,
-0.024907076731324196,
-0.0004230142221786082,
0.00459609879180789,
-0.0164326261729002,
0.012195401825010777,
0.00578289944678545,
-0.019152509048581123,
0.020789476111531258,
-0.021343527361750603,
0.005833267699927092,
-0.013549046590924263,
-0.0007905447273515165,
0.0052288491278886795,
-0.015274157747626305,
-0.013574231415987015,
0.0088333236053586,
0.001964360009878874,
-0.00809668842703104,
0.00184945750515908,
-0.0032267130445688963,
0.013372758403420448,
-0.013662375509738922,
0.018661418929696083,
-0.0003765810397453606,
-0.032437123358249664,
0.027727697044610977,
-0.04120119288563728,
0.0012883242452517152,
0.00465591112151742,
-0.03472887724637985,
0.014216425828635693,
-0.008934060111641884,
-0.01211984921246767,
-0.019139917567372322,
-0.02359750308096409,
-0.010860644280910492,
-0.013246838003396988,
0.020525043830275536,
-0.008436674252152443,
0.018422171473503113
] | 2024-07-04 | 1 | 38963234 | [
"lentiviral vectors",
"therapeutic cells",
"effective cancer therapy",
"local production",
"chimeric antigen receptor technology",
"high titers",
"Production",
"P100 plates",
"therapeutic lentiviral or retroviral vectors",
"untapped markets",
"numerous challenges",
"academic settings",
"high cell-density cultures",
"developing countries",
"all current clinical therapies",
"these lentiviral vectors",
"genetically modified T cells",
"T-175",
"The calcium phosphate precipitation method",
"principle",
"patients",
"P100",
"gradually increasing production",
"protocols",
"this therapy",
"a global shortage",
"the only economically viable approach",
"6-well plates",
"5-layer stacks",
"the form"
] | [
"CD19 CAR",
"calcium phosphate transfection",
"chimeric antigen receptor therapy",
"gene transfer",
"lentiviral vector production",
"ultracentrifugation"
] | 0 | 10.1002/bit.28794 | [
"Keyer",
"Syzdykova",
"Ingirbay",
"Sedova",
"Zauatbayeva",
"Kulatay",
"Shevtsov",
"Shustov"
] | [
"Laboratory for Genetic Engineering, National Center for Biotechnology, Astana, Kazakhstan.",
"Laboratory for Genetic Engineering, National Center for Biotechnology, Astana, Kazakhstan.",
"Laboratory for Genetic Engineering, National Center for Biotechnology, Astana, Kazakhstan.",
"Laboratory for Genetic Engineering, National Center for Biotechnology, Astana, Kazakhstan.",
"Laboratory for Genetic Engineering, National Center for Biotechnology, Astana, Kazakhstan.",
"Laboratory for Genetic Engineering, National Center for Biotechnology, Astana, Kazakhstan.",
"Laboratory for Genetic Engineering, National Center for Biotechnology, Astana, Kazakhstan.",
"Laboratory for Genetic Engineering, National Center for Biotechnology, Astana, Kazakhstan."
] | [
"38963234"
] | [] | 8.879236 | 2.916332 |
38962014 | 766 | Universal CAR 2.0 to overcome current limitations in CAR therapy. | Chimeric antigen receptor (CAR) T cell therapy has effectively complemented the treatment of advanced relapsed and refractory hematological cancers. The remarkable achievements of CD19- and BCMA-CAR T therapies have raised high expectations within the fields of hematology and oncology. These groundbreaking successes are propelling a collective aspiration to extend the reach of CAR therapies beyond B-lineage malignancies. Advanced CAR technologies have created a momentum to surmount the limitations of conventional CAR concepts. Most importantly, innovations that enable combinatorial targeting to address target antigen heterogeneity, using versatile adapter CAR concepts in conjunction with recent transformative next-generation CAR design, offer the promise to overcome both the bottleneck associated with CAR manufacturing and patient-individualized treatment regimens. In this comprehensive review, we delineate the fundamental prerequisites, navigate through pivotal challenges, and elucidate strategic approaches, all aimed at paving the way for the future establishment of multitargeted immunotherapies using universal CAR technologies. | [
0.03926840052008629,
0.0014471658505499363,
0.06034386157989502,
0.06488028168678284,
-0.03851233050227165,
-0.03012467734515667,
-0.0016996815102174878,
0.024146996438503265,
0.00392506830394268,
0.015653017908334732,
-0.0003994473081547767,
-0.013372994028031826,
-0.05377550050616264,
0.012498787604272366,
0.02010674588382244,
-0.019976794719696045,
0.03347973898053169,
0.0037301438860595226,
0.04219817370176315,
0.03636225685477257,
0.00794464536011219,
-0.0015461047878488898,
-0.002219479763880372,
0.0016110795550048351,
-0.03444845229387283,
-0.010130160488188267,
-0.013491129502654076,
0.033148959279060364,
-0.02073286660015583,
-0.03515727072954178,
0.01167183555662632,
-0.017838533967733383,
-0.03166044503450394,
0.007596143987029791,
-0.0030744890682399273,
0.04881379008293152,
-0.0004507626290433109,
0.003774444805458188,
-0.015204101800918579,
-0.007631585001945496,
0.04212729260325432,
0.02213868498802185,
0.03298356756567955,
0.07763896882534027,
-0.06511655449867249,
0.01203805673867464,
-0.006521106697618961,
-0.04630930721759796,
0.006178512237966061,
0.017460498958826065,
-0.029723014682531357,
-0.0013607789296656847,
-0.03541716933250427,
0.03903213143348694,
-0.04994789510965347,
0.044726286083459854,
-0.031353291124105453,
0.018618231639266014,
0.006568361073732376,
-0.00529249245300889,
0.01951606571674347,
-0.02256397344172001,
-0.01414087787270546,
-0.009533573873341084,
-0.08104128390550613,
0.03281817585229874,
-0.04623842611908913,
-0.026509715244174004,
0.009013775736093521,
0.028896061703562737,
0.007607957813888788,
0.00751935550943017,
0.004309010226279497,
0.0020068350713700056,
0.04519882798194885,
-0.014105437323451042,
-0.01676349714398384,
0.05240512266755104,
-0.0072358292527496815,
-0.004412379115819931,
0.015617577359080315,
-0.004811088088899851,
0.006432504393160343,
-0.05703605338931084,
-0.012091218493878841,
0.008753877133131027,
0.02504482865333557,
-0.02509208396077156,
-0.0410640686750412,
-0.00733624491840601,
0.004527561832219362,
-0.00038541865069419146,
-0.05098749324679375,
0.04848301038146019,
-0.00946859922260046,
0.004238128662109375,
-0.04581313580274582,
-0.0631791278719902,
0.02629707008600235,
0.034306690096855164,
0.061288949102163315,
0.016444530338048935,
-0.009574921801686287,
-0.00016502120706718415,
0.061241697520017624,
-0.015901103615760803,
-0.026722360402345657,
-0.009817100130021572,
0.01656266488134861,
-0.012959517538547516,
-0.0008180917357094586,
-0.032180242240428925,
-0.0023243254981935024,
0.05656351149082184,
-0.020354831591248512,
-0.04621479660272598,
-0.014188132248818874,
-0.0010883277282118797,
0.011358775198459625,
0.0380634143948555,
-0.018878130242228508,
0.03128241002559662,
0.034661099314689636,
-0.01734236255288124,
0.005363374017179012,
-0.03099888376891613,
0.06634517014026642,
-0.01104571484029293,
-0.03844144940376282,
-0.06521106511354446,
0.02974664233624935,
0.023993419483304024,
0.013384807854890823,
-0.01777946576476097,
-0.07456743717193604,
0.005106428172439337,
-0.031991224735975266,
-0.02223319374024868,
-0.03017193078994751,
-0.017555007711052895,
0.013361180201172829,
-0.024973947554826736,
-0.021666139364242554,
-0.014377149753272533,
-0.025493746623396873,
-0.04808134585618973,
-0.0006778052193112671,
0.02509208396077156,
-0.01627913862466812,
0.02151256427168846,
-0.05316119268536568,
0.027289412915706635,
0.04999515041708946,
0.0015224774833768606,
-0.008429002948105335,
-0.0558074414730072,
-0.01932704821228981,
0.06601438671350479,
-0.023851655423641205,
-0.06308461725711823,
-0.01670442894101143,
-0.00707043893635273,
-0.02929772436618805,
-0.0380634143948555,
0.032770924270153046,
-0.023272790014743805,
-0.02939223311841488,
0.02915596216917038,
-0.057083308696746826,
-0.0037006097845733166,
-0.03931565582752228,
-0.046710968017578125,
-0.0903976559638977,
-0.022020548582077026,
-0.02629707008600235,
0.020024050027132034,
0.017058836296200752,
0.014837879687547684,
-0.034070417284965515,
-0.0375908724963665,
0.03534628823399544,
0.015416746027767658,
0.05108200013637543,
-0.024714048951864243,
-0.04319051653146744,
0.014400776475667953,
-0.02412336878478527,
0.006786912679672241,
-0.05174356326460838,
-0.014400776475667953,
0.01254604198038578,
0.02785646542906761,
0.0549096055328846,
0.03607873246073723,
0.008340400643646717,
-0.015074151568114758,
0.03244014084339142,
0.022434024140238762,
-0.036196865141391754,
-0.0345902182161808,
0.02212687022984028,
-0.039788201451301575,
-0.007861950434744358,
0.008700715377926826,
-0.04484442248940468,
-0.004754973575472832,
-0.020283948630094528,
0.025162965059280396,
-0.002020125277340412,
0.0006331350305117667,
0.0355353057384491,
-0.017602263018488884,
-0.00655064033344388,
0.03633863106369972,
-0.04304875433444977,
-0.03714195266366005,
-0.021465308964252472,
0.04210366681218147,
0.004689998924732208,
0.01768495701253414,
-0.006462038494646549,
-0.006845980416983366,
0.0012500263983383775,
0.008068688213825226,
-0.027667447924613953,
0.0020422758534550667,
0.013408434577286243,
-0.03371601179242134,
-0.01796848326921463,
-0.012179819867014885,
0.011441470123827457,
-0.0022106196265667677,
0.04363943263888359,
-0.02417062222957611,
-0.04526970908045769,
-0.025635508820414543,
0.016976142302155495,
0.009586735628545284,
0.06213952973484993,
-0.03331434726715088,
0.003948695491999388,
0.02726578526198864,
0.051696307957172394,
-0.018145687878131866,
-0.022445837035775185,
0.00183701456990093,
-0.01612556166946888,
-0.0459076464176178,
0.02993565984070301,
0.0024749489966779947,
0.008222265169024467,
0.02620256133377552,
-0.02209142968058586,
0.03229837864637375,
0.04226905480027199,
0.01300677191466093,
0.01300677191466093,
-0.04392296075820923,
0.010419594123959541,
-0.030502712354063988,
-0.01904352195560932,
0.020886441692709923,
-0.04985338822007179,
-0.030337322503328323,
-0.049664370715618134,
0.01203805673867464,
0.003842372912913561,
0.028021857142448425,
0.047301650047302246,
-0.016787122935056686,
0.04741978645324707,
0.01859460398554802,
0.049239080399274826,
-0.030148303136229515,
-0.057461343705654144,
0.009982490912079811,
0.0028544608503580093,
0.04886104539036751,
0.03251102194190025,
0.03017193078994751,
0.015558509156107903,
0.016007427126169205,
0.024111555889248848,
-0.013845537789165974,
0.013774655759334564,
-0.014247200451791286,
0.005948146805167198,
-0.013302111998200417,
0.009255954995751381,
-0.03166044503450394,
0.022741178050637245,
0.004752019885927439,
-0.026367953047156334,
-0.04838849976658821,
0.009415438398718834,
0.005260004661977291,
0.01132924109697342,
-0.001124506932683289,
-0.027761956676840782,
0.0272185318171978,
-0.024288758635520935,
0.02547011896967888,
-0.01535767875611782,
-0.03225112333893776,
0.03428306430578232,
0.02039027214050293,
-0.01681075058877468,
-0.03926840052008629,
0.0229538232088089,
0.027643820270895958,
0.015085965394973755,
-0.005206843838095665,
0.028565282002091408,
0.008883826434612274,
-0.017956670373678207,
0.02440689504146576,
-0.0042883362621068954,
-0.08345126360654831,
-0.008588486351072788,
-0.05651625618338585,
-0.02378077432513237,
0.009450878947973251,
-0.024714048951864243,
0.029085081070661545,
0.015003270469605923,
-0.036102358251810074,
0.006219859700649977,
-0.05509862303733826,
0.02974664233624935,
-0.04198553040623665,
0.0020068350713700056,
-0.03915026783943176,
0.04111132398247719,
-0.016893446445465088,
-0.001078729284927249,
-0.0033137144055217505,
-0.020354831591248512,
-0.06889690458774567,
0.04044976085424423,
0.01036052592098713,
0.011033901013433933,
0.021973293274641037,
-0.049333587288856506,
0.05207434296607971,
0.0136092659085989,
-0.006798726040869951,
0.0010048942640423775,
0.026226188987493515,
-0.0069109550677239895,
0.019504250958561897,
0.004421239253133535,
-0.003013944486156106,
0.05060945823788643,
0.020898256450891495,
-0.0024365547578781843,
0.05457882583141327,
-0.027478430420160294,
0.006633335724473,
0.014341709204018116,
-0.015428559854626656,
0.0038660001009702682,
0.013278485275804996,
-0.038913995027542114,
0.01815750077366829,
0.040945932269096375,
0.06884965300559998,
-0.013491129502654076,
0.03773263469338417,
-0.019067147746682167,
-0.03865409642457962,
-0.006154885049909353,
-0.005493323318660259,
0.017212413251399994,
0.013999114744365215,
-0.025588255375623703,
0.0279037207365036,
0.035086389631032944,
-0.010602705180644989,
0.016598105430603027,
0.0028116365429013968,
0.02832900919020176,
-0.02750205807387829,
-0.00794464536011219,
-0.02799822948873043,
0.004796321038156748,
0.022315887734293938,
0.006840073503553867,
-0.005847731605172157,
-0.07362234592437744,
0.028305383399128914,
-0.0060899099335074425,
-0.013668334111571312,
-0.013585638254880905,
-0.006568361073732376,
-0.0172951091080904,
0.06941670924425125,
-0.013160348869860172,
0.07853680104017258,
0.05462608113884926,
0.007991899736225605,
-0.0030168977100402117,
-0.05476784333586693,
-0.008493977598845959,
-0.03952830284833908,
0.02242221124470234,
-0.011683649383485317,
0.034259434789419174,
0.034070417284965515,
0.010525916703045368,
-0.021146342158317566,
-0.012534228153526783,
0.03534628823399544,
0.03941016644239426,
0.029699387028813362,
-0.0008461489924229681,
0.0027245113160461187,
-0.04640381410717964,
0.042410820722579956,
-0.0202957633882761,
0.026462461799383163,
0.056988801807165146,
-0.017259668558835983,
0.013751029036939144,
-0.018181128427386284,
0.001221969141624868,
-0.005289538763463497,
0.03910301253199577,
0.012486973777413368,
-0.004943991079926491,
-0.034070417284965515,
-0.03440120071172714,
0.05599645897746086,
0.02014218643307686,
-0.008257705718278885,
0.01005337294191122,
0.05987131968140602,
-0.018925385549664497,
0.029085081070661545,
-0.027691075578331947,
0.034755606204271317,
-0.02601354382932186,
-0.0032575998920947313,
0.017791280522942543,
-0.01879543624818325,
0.020283948630094528,
0.008009620010852814,
-0.01646815612912178,
0.03303082287311554,
-0.028588909655809402,
-0.003121743444353342,
-0.024737676605582237,
-0.038772232830524445,
-0.009149632416665554,
0.02048478089272976,
-0.04793958365917206,
0.01564120501279831,
0.02891968935728073,
-0.06809358298778534,
-0.0009170306148007512,
0.03648039326071739,
0.023449992761015892,
-0.04423011466860771,
0.012888636440038681,
-0.03258190676569939,
-0.006225766614079475,
0.059162501245737076,
0.03633863106369972,
-0.020413897931575775,
-0.00011998186528217047,
-0.02547011896967888,
0.017649516463279724,
0.016479970887303352,
-0.025824526324868202,
0.013502943329513073,
-0.02150074951350689,
0.03607873246073723,
0.017992110922932625,
0.020307576283812523,
0.021347172558307648,
-0.003213298972696066,
-0.030053794384002686,
0.0009509947267360985,
-0.02896694466471672,
-0.00681644631549716,
0.013798283413052559,
0.005803430452942848,
-0.03414130210876465,
-0.017791280522942543,
-0.029723014682531357,
0.018039366230368614,
-0.013396620750427246,
0.01307765394449234,
-0.0022002828773111105,
-0.010543636977672577,
-0.02528110146522522,
-0.0380634143948555,
-0.0208746287971735,
-0.0048140413127839565,
-0.04226905480027199,
0.014353522099554539,
-0.0013689007610082626,
0.009551294147968292,
0.014400776475667953,
0.03244014084339142,
0.055145878344774246,
0.04853026196360588,
0.013715588487684727,
0.0682826042175293,
-0.002550260629504919,
0.03333797678351402,
-0.053444720804691315,
-0.022162310779094696,
0.027691075578331947,
-0.01748412661254406,
-0.03284180536866188,
-0.009846634231507778,
-0.04623842611908913,
-0.009019683115184307,
0.009592642076313496,
0.0022327702026814222,
-0.006810539867728949,
-0.011919921264052391,
-0.005729595199227333,
0.018275637179613113,
0.023851655423641205,
-0.023768961429595947,
-0.033834148198366165,
-0.026509715244174004,
-0.03473198041319847,
-0.029864776879549026,
0.01087441761046648,
0.0007553319446742535,
-0.00177056307438761,
0.020224880427122116,
-0.00855304580181837,
-0.027880093082785606,
-0.04165475070476532,
0.05037318542599678,
-0.013278485275804996,
-0.030691729858517647,
-0.00796827208250761,
-0.016255510970950127,
0.028588909655809402,
-0.001984684495255351,
-0.022540345788002014,
0.02925047092139721,
-0.00982891395688057,
-0.01831107772886753,
0.024666793644428253,
0.007909204810857773,
0.017082463949918747,
-0.02107546105980873,
0.017401430755853653,
-0.008239985443651676,
0.035866085439920425,
-0.044631775468587875,
-0.0069404891692101955,
-0.027242159470915794,
-0.003201485378667712,
-0.03714195266366005,
-0.017755838111042976,
-0.022209566086530685,
0.018275637179613113,
-0.010183322243392467,
-0.021949665620923042,
0.045411475002765656,
-0.008275425992906094,
-0.018346518278121948,
-0.029864776879549026,
-0.0034318503458052874,
0.0026048985309898853,
0.006485665682703257,
0.014235386624932289,
-0.036834802478551865,
0.02984115108847618,
0.008222265169024467,
0.00027152817347086966,
0.026084426790475845,
-0.013349366374313831,
0.03182583674788475,
-0.021288104355335236,
-0.023036517202854156,
-0.022197751328349113,
0.04834124445915222,
0.0072358292527496815,
0.012097124941647053,
-0.05372824892401695,
-0.011459190398454666,
0.01210893876850605,
0.019728709012269974,
0.045789510011672974,
0.011707276105880737,
0.041914649307727814,
0.021784275770187378,
-0.049333587288856506,
0.03173132613301277,
-0.0007549627916887403,
0.002581271342933178,
-0.01220344752073288,
-0.010301457718014717,
0.0196105744689703,
-0.025777272880077362,
-0.009450878947973251,
-0.042552582919597626,
-0.03728371858596802,
0.007832416333258152,
0.0005478556267917156,
-0.03971732035279274,
0.0013689007610082626,
0.003972322680056095,
0.04810497537255287,
0.034897372126579285,
-0.027714703232049942,
0.0002890639880206436,
0.0010934962192550302,
0.03371601179242134,
-0.029628505930304527,
0.0026698734145611525,
0.020165812224149704,
-0.013987300917506218,
-0.0017410290893167257,
-0.009161446243524551,
-0.025588255375623703,
-0.003928021527826786,
0.008027340285480022,
-0.02262304164469242,
0.003774444805458188,
-0.006905048619955778,
0.016113748773932457,
0.00009012483496917412,
0.008110035210847855,
-0.04465540498495102,
-0.017803093418478966,
0.023449992761015892,
-0.010384153574705124,
-0.037992533296346664,
0.03248739615082741,
-0.02343817986547947,
-0.0014538109535351396,
0.005889079067856073,
-0.02363901026546955,
0.016539039090275764,
-0.015274982899427414,
-0.010065185837447643,
0.019988609477877617,
-0.02271755039691925,
-0.01922072470188141,
0.005738455802202225,
0.007483914960175753,
-0.008470349945127964,
-0.013833723962306976,
-0.0033845959696918726,
0.02547011896967888,
-0.02915596216917038,
0.012699618935585022,
-0.034897372126579285,
0.006231673527508974,
0.0064147841185331345,
0.06010758876800537,
0.08973609656095505,
-0.028021857142448425,
0.010892137885093689,
-0.004651604685932398,
-0.01970508322119713,
-0.011713183484971523,
0.0024306478444486856,
0.03210936114192009,
-0.005903846118599176,
-0.00017194323299918324,
0.016527224332094193,
0.07664662599563599,
0.01666898839175701,
-0.0022386768832802773,
-0.014010928571224213,
-0.000014386287148226984,
0.0011259836610406637,
0.004433053079992533,
-0.007980085909366608,
-0.014377149753272533,
-0.0035293125547468662,
-0.018192941322922707,
0.01570027321577072,
-0.04137122258543968,
-0.06256482005119324,
0.007684745825827122,
0.0040254839695990086,
0.0051389154978096485,
0.024973947554826736,
0.017401430755853653,
-0.01573571376502514,
0.0030951627995818853,
-0.005614412948489189,
-0.023131025955080986,
-0.0062848343513906,
0.036196865141391754,
0.013999114744365215,
0.004666371736675501,
-0.010230576619505882,
-0.030833492055535316,
-0.02349724806845188,
0.03893762081861496,
0.02445415034890175,
0.030549965798854828,
-0.02426513098180294,
0.014306267723441124,
-0.026226188987493515,
-0.0015224774833768606,
-0.02154800482094288,
0.007111786399036646,
0.03782714158296585,
0.006004261784255505,
-0.005118241533637047,
-0.031211527064442635,
-0.03333797678351402,
0.005197983235120773,
-0.0005456405924633145,
0.009681244380772114,
0.03666941076517105,
-0.01835833303630352,
0.019894100725650787,
0.0022312933579087257,
0.02101639285683632,
-0.02165432646870613,
0.006544733885675669,
0.02795097418129444,
0.029321352019906044,
-0.03036094829440117,
0.04619117081165314,
-0.03036094829440117,
0.001978777814656496,
-0.007631585001945496,
-0.03652764856815338,
-0.027478430420160294,
-0.005289538763463497,
-0.004016623366624117,
0.020071303471922874,
-0.0014287071535363793,
-0.027667447924613953,
-0.00566462054848671,
-0.011902200989425182,
0.03536991402506828,
-0.041820138692855835,
-0.0272185318171978,
0.0024144041817635298,
-0.019445182755589485,
0.02135898731648922,
0.01811024732887745,
0.006840073503553867,
-0.008375841192901134,
-0.014802439138293266,
-0.0013046642998233438,
0.008322680369019508,
-0.0006154146394692361,
-0.015912918373942375,
0.015062338672578335,
-0.03704744577407837,
-0.0005260743200778961,
0.000885281537193805,
-0.04363943263888359,
-0.024525031447410583,
-0.05070396512746811,
0.009362276643514633,
0.007808788679540157,
0.009994304738938808,
0.0010831593535840511,
0.011559606529772282,
0.03161318972706795,
0.025541000068187714,
0.0016598106594756246,
0.020862815901637077,
-0.009970677085220814,
-0.011949455365538597,
0.00953948125243187,
-0.022315887734293938,
-0.013325739651918411,
0.03541716933250427,
-0.0033698291517794132,
0.023284602910280228,
-0.033243466168642044,
0.010614518076181412,
-0.006810539867728949,
0.011677742004394531,
-0.015286796726286411,
0.015723900869488716,
0.0027880093548446894,
-0.015971984714269638,
-0.007489821407943964,
0.00362086808308959,
-0.017318734899163246,
-0.015251356177031994,
-0.018819062039256096,
0.020236695185303688,
-0.02993565984070301,
0.0029105753637850285,
-0.011317427270114422,
0.023260975256562233,
0.04285973682999611,
-0.07371685653924942,
-0.013821910135447979,
-0.0028958083130419254,
-0.010661772452294827,
-0.01917347125709057,
0.02684049680829048,
-0.03095162846148014,
-0.009698964655399323,
-0.00003133372592856176,
0.004630930721759796,
0.02712402306497097,
-0.025115711614489555,
0.009740312583744526,
0.0011562559520825744,
-0.011890387162566185,
-0.012416092678904533,
-0.037118326872587204,
-0.05495686084032059,
-0.035322658717632294,
0.02596629038453102,
0.007206295151263475,
-0.003668122459203005,
-0.018429214134812355,
0.048364873975515366,
-0.011961269192397594,
0.008801131509244442,
-0.005717781838029623,
-0.010401873849332333,
-0.04871927946805954,
-0.01878362149000168,
0.014625235460698605,
0.01593654416501522,
-0.045884016901254654,
0.030691729858517647,
0.00262704910710454,
-0.03915026783943176,
0.03166044503450394,
-0.008493977598845959,
-0.005073940847069025,
-0.00025122356601059437,
-0.022410396486520767,
0.021725207567214966,
0.027714703232049942,
-0.0018030505161732435,
-0.011057528667151928,
-0.013680147007107735,
-0.010206948965787888,
0.00020932219922542572,
0.012876822613179684,
-0.0018133873818442225,
-0.009657616727054119,
-0.020307576283812523,
-0.04718351364135742,
-0.0033698291517794132,
0.005029639694839716,
-0.01503871101886034,
-0.02396979182958603,
0.04741978645324707,
0.02828175574541092,
0.001267746789380908,
-0.028069110587239265,
0.049569860100746155,
0.05623273178935051,
-0.0018532583490014076,
0.0014685780042782426,
-0.026178935542702675,
-0.02785646542906761,
0.03265278786420822,
-0.03298356756567955,
0.009049216285347939,
-0.02102820575237274,
0.020378457382321358,
-0.028754299506545067,
0.009669430553913116,
0.005534671247005463,
0.02547011896967888,
-0.0041288528591394424,
-0.014377149753272533,
0.01406999584287405,
0.007407126482576132,
-0.030928000807762146,
-0.021299919113516808,
-0.019409742206335068,
0.0028396937996149063,
-0.027880093082785606,
-0.02101639285683632,
-0.016680801287293434,
0.009586735628545284,
0.01854735054075718,
-0.00419087428599596,
-0.019799591973423958,
-0.006497479509562254,
0.00014785457460675389,
-0.00867118127644062,
-0.003987089730799198,
-0.02537561021745205,
-0.011016180738806725,
0.0057561760768294334,
0.004849482327699661,
-0.030006540939211845,
0.03652764856815338,
-0.03288906067609787,
0.010118347592651844,
-0.0429069921374321,
-0.045789510011672974,
-0.04052064195275307,
0.01632639393210411,
-0.014861507341265678,
0.007371685467660427,
-0.010260110720992088,
0.025848153978586197,
-0.0036149611696600914,
0.02324916236102581,
-0.03777989000082016,
-0.006432504393160343,
0.010833069682121277,
0.019303420558571815,
-0.005596692208200693,
0.004438959527760744,
-0.005576018709689379,
0.057603105902671814,
0.01009471993893385,
-0.006905048619955778,
-0.026651479303836823,
-0.014223572798073292,
-0.006308461539447308,
0.009385904297232628,
0.027691075578331947,
0.004503934644162655,
-0.0077615343034267426,
0.004941037856042385,
0.019634200260043144,
-0.011417843401432037,
0.016149189323186874,
0.00539881456643343,
0.0357479490339756,
0.0046397908590734005,
0.031943969428539276,
-0.008411282673478127,
0.01873636804521084,
-0.0025281100533902645,
-0.005729595199227333,
-0.009633990004658699,
-0.02532835491001606,
0.0562799833714962,
-0.00769065273925662,
-0.06001308187842369,
0.02818724699318409,
0.004081598483026028,
0.015416746027767658,
-0.03515727072954178,
0.049286335706710815,
0.03917389363050461,
0.06204501911997795,
-0.0014479041565209627,
0.023355484008789062,
0.01300677191466093,
-0.017448686063289642,
-0.013739215210080147,
0.032180242240428925,
-0.033739637583494186,
0.05420079082250595,
-0.00406978465616703,
-0.015298610553145409,
-0.009681244380772114,
0.0018296311609447002,
-0.015771154314279556,
-0.0006778052193112671,
0.023426366969943047,
0.021134527400135994,
0.014459844678640366,
-0.05226336047053337,
0.0461202897131443,
-0.0037419574800878763,
-0.0352754071354866,
0.006349809467792511,
0.01679893769323826,
0.0020924836862832308,
0.034259434789419174,
0.043072380125522614,
-0.03903213143348694,
-0.00045113181113265455,
0.015676645562052727,
0.0507512204349041,
0.016397275030612946,
-0.004973525181412697,
-0.004013670142740011,
-0.023284602910280228,
0.008358120918273926,
-0.005694154649972916,
-0.024052487686276436,
-0.025257473811507225,
0.009143725037574768,
0.04756154865026474,
0.010915765538811684,
-0.03614961355924606,
-0.02362719736993313,
0.019539691507816315,
-0.03695293515920639,
-0.016184629872441292,
-0.07688289880752563,
0.046569205820560455,
0.027714703232049942,
-0.006497479509562254,
-0.030006540939211845,
0.0053043058142066,
-0.020461153239011765,
-0.045505981892347336,
-0.004633883945643902,
0.03244014084339142,
0.011724996380507946,
0.025730017572641373,
-0.03017193078994751,
0.022315887734293938,
0.024737676605582237,
0.0041849673725664616,
0.009362276643514633,
0.011925827711820602,
-0.015723900869488716,
0.004013670142740011,
-0.0484357550740242,
-0.027053141966462135,
-0.003641541814431548,
-0.02450140379369259,
0.005912706255912781,
-0.0019832078833132982,
0.04101681336760521,
0.020638357847929,
-0.01796848326921463,
0.0030833492055535316,
-0.006704217288643122,
0.024548659101128578,
0.022504905238747597,
0.003080395981669426,
-0.000018793312847265042,
0.0059747276827692986,
-0.013644706457853317,
-0.01962238736450672,
0.011884480714797974,
-0.025942662730813026,
0.0659671351313591,
0.02620256133377552,
-0.00708225229755044,
-0.026793241500854492,
-0.0209809523075819,
0.004557095933705568,
0.0362204946577549,
-0.02131173200905323,
0.003337341593578458,
-0.02096913754940033,
-0.022174125537276268,
0.016113748773932457,
0.025304729118943214,
0.03258190676569939,
0.04437187686562538,
0.009746219031512737,
0.006391156930476427,
-0.0001772962714312598,
0.014885134063661098,
0.01976415142416954,
-0.004111132584512234,
0.01535767875611782,
0.0136092659085989,
-0.007844229228794575,
0.032132986932992935,
-0.0009295825730077922,
0.013821910135447979,
-0.02974664233624935,
0.017980298027396202,
0.019823219627141953,
0.0327472947537899,
0.017755838111042976,
-0.008641647174954414,
0.010401873849332333,
0.0002802037924993783,
-0.030691729858517647,
0.016432715579867363,
-0.010685400106012821,
-0.018086619675159454,
0.015026897192001343,
-0.0027761957608163357,
0.008753877133131027,
-0.03536991402506828,
0.006692403927445412,
0.019740523770451546,
0.027572939172387123,
-0.017507754266262054,
-0.007029091473668814,
-0.008523511700332165,
-0.028612535446882248,
-0.02207961678504944,
0.0011274603893980384,
-0.018192941322922707,
-0.005375187378376722,
-0.004819948226213455,
-0.016479970887303352,
0.00003050308077945374,
-0.00963989645242691,
0.010271924547851086,
-0.0015726853162050247,
0.02246946468949318,
0.03359787538647652,
-0.00655064033344388,
-0.029132334515452385,
0.030384575948119164,
0.010431407950818539,
-0.023272790014743805,
-0.04895555227994919,
0.05679978430271149,
-0.015345864929258823,
-0.05684703588485718,
0.011677742004394531,
-0.00028943317010998726,
-0.007962365634739399,
0.018228383734822273,
0.005050313659012318,
-0.021914225071668625,
0.021252663806080818,
-0.0027230344712734222,
0.018724553287029266,
-0.017082463949918747,
0.01748412661254406,
0.003201485378667712,
-0.005682340823113918,
-0.02698225900530815,
-0.0007568086730316281,
0.0052865855395793915,
0.008564858697354794,
-0.01748412661254406,
-0.031069764867424965,
0.02518659271299839,
-0.015582136809825897,
0.017543194815516472,
-0.0011946501908823848,
0.010395966470241547,
0.008163196966052055,
0.0011267219670116901,
0.003969368990510702,
0.01917347125709057,
-0.008334494195878506,
-0.015251356177031994,
0.012463347055017948,
0.009149632416665554,
0.02334367111325264,
0.020744679495692253,
-0.016208257526159286,
-0.008517604321241379,
-0.01767314411699772,
-0.025824526324868202,
0.011435563676059246,
0.05032593011856079,
-0.02285931445658207,
-0.053586483001708984,
0.05831192433834076,
0.002591608325019479,
-0.021831531077623367,
0.004819948226213455,
0.01363289263099432,
-0.003508638823404908,
-0.024690421298146248,
0.00035126996226608753,
0.02939223311841488,
0.03915026783943176,
-0.016940699890255928,
-0.0035677067935466766,
0.019303420558571815,
-0.009569015353918076,
-0.002031938871368766,
0.008505791425704956,
0.008186823688447475,
0.017495939508080482,
0.007501635234802961,
-0.02750205807387829,
0.008056874386966228,
-0.004267662763595581,
0.009834821335971355,
0.046805478632450104,
0.02639157883822918,
-0.0053013525903224945,
0.04210366681218147,
-0.003086302662268281,
0.019256165251135826,
-0.020567474886775017,
-0.008541231974959373,
-0.0043444507755339146,
-0.01656266488134861,
-0.03118790127336979,
-0.0461202897131443,
0.013313925825059414,
-0.009704871103167534,
0.010791722685098648,
-0.01724785380065441,
0.010803536511957645,
-0.010549543425440788,
-0.02891968935728073,
0.004037297330796719,
-0.004137712996453047,
0.011973082087934017,
-0.02131173200905323,
0.007962365634739399,
-0.04082779586315155,
-0.026816869154572487,
0.02532835491001606,
-0.011789971962571144,
0.004568909294903278,
0.024111555889248848,
0.014436217956244946,
0.01762588880956173,
0.014152691699564457,
0.01372740138322115,
-0.008948801085352898,
0.00610172376036644,
-0.047963209450244904,
0.010992554016411304,
-0.03187308833003044,
-0.009025589562952518,
0.004943991079926491,
-0.033243466168642044,
-0.053444720804691315,
0.019634200260043144,
-0.006308461539447308,
-0.00982891395688057,
0.006651055999100208,
-0.004474400542676449,
0.01574752666056156,
-0.009303209371864796,
0.018441027030348778,
0.017495939508080482,
-0.020354831591248512,
0.02135898731648922,
0.0009532097610644996,
0.0020275088027119637,
-0.0017587494803592563,
0.008375841192901134,
-0.049711622297763824,
0.017744025215506554,
0.010502289049327374,
0.022552160546183586,
-0.018192941322922707,
0.013467502780258656,
0.0077201868407428265,
-0.002770288847386837,
0.05821741372346878,
0.012723245657980442,
0.0029666898772120476,
-0.013680147007107735,
-0.035039134323596954,
-0.0031453706324100494,
0.01363289263099432,
0.0281399916857481,
0.02998291328549385,
0.017401430755853653,
-0.05084572732448578,
-0.015948358923196793,
-0.016598105430603027,
-0.011051621288061142,
-0.04309600964188576,
-0.014235386624932289,
-0.003951648715883493,
0.011565512977540493,
-0.034755606204271317,
-0.007672932464629412,
0.0033284814562648535,
0.01970508322119713,
0.005903846118599176,
-0.009551294147968292,
-0.018122060224413872,
-0.021713394671678543,
-0.011417843401432037,
-0.006462038494646549,
0.027336668223142624,
0.020272135734558105,
0.0375908724963665,
0.007454380858689547,
0.006054469384253025,
-0.029699387028813362,
0.04203278571367264,
0.024784930050373077,
0.005466742906719446,
-0.02320190705358982,
-0.029723014682531357,
0.02218593843281269,
0.00939181074500084,
-0.010236483067274094,
0.015960171818733215,
0.03409404680132866,
-0.0019108495907858014,
-0.011961269192397594,
0.04401746764779091,
0.014814252965152264,
-0.01646815612912178,
-0.020331203937530518,
-0.014294454827904701,
0.005209797061979771,
-0.0007892960566096008,
-0.001978777814656496,
-0.0033343881368637085,
-0.014152691699564457,
0.005168449599295855,
-0.013136722147464752,
-0.01622007042169571,
-0.022752990946173668,
-0.003857139963656664,
-0.025682764127850533,
0.002697930671274662,
-0.010354619473218918,
-0.03520452603697777,
-0.07073982805013657,
0.011967175640165806,
0.005203890148550272,
-0.020272135734558105,
0.008322680369019508,
-0.02170158177614212,
0.006491572596132755,
0.0334324836730957,
-0.026769615709781647,
0.008269519545137882,
0.026911377906799316,
0.016976142302155495,
0.0022061895579099655,
0.021866971626877785,
0.009238233789801598,
0.013656520284712315,
-0.0027407549787312746,
-0.013597452081739902,
-0.019433369860053062,
-0.005330886226147413,
0.04349767044186592,
-0.01266417745500803,
0.01593654416501522,
0.03284180536866188,
-0.03149505332112312,
0.025351982563734055,
0.0005345653626136482,
-0.012286142446100712,
0.02702951431274414,
-0.003851233283057809,
-0.009055123664438725,
-0.005008965730667114,
-0.021087273955345154,
-0.004179060459136963,
0.018996266648173332,
0.027738329023122787,
-0.012416092678904533,
-0.0062375799752771854,
0.003219205653294921,
0.038630466908216476,
-0.025635508820414543,
-0.02111090160906315,
0.017472311854362488,
0.03244014084339142,
-0.00443009939044714,
-0.010159694589674473,
0.010992554016411304,
-0.006143071223050356,
-0.037803515791893005,
-0.00038025021785870194,
0.004749066662043333,
-0.016692614182829857,
0.02828175574541092,
-0.0019315234385430813,
0.0028574143070727587,
0.00832858681678772,
-0.0069404891692101955,
0.018429214134812355,
0.0034643379040062428,
-0.012994959019124508,
0.011719089932739735,
-0.01724785380065441,
-0.0007398266461677849,
-0.012309770099818707,
-0.019492438063025475,
-0.011417843401432037,
0.008375841192901134,
-0.03655127435922623,
0.015227728523314,
-0.009137818589806557,
0.0010898044565692544,
-0.001234521041624248,
-0.00041642936412245035,
-0.008239985443651676,
-0.0017365990206599236,
-0.02596629038453102,
0.036456767469644547,
-0.009887982159852982,
-0.016196444630622864,
-0.023509060963988304,
-0.007932831533253193,
0.00010623009438859299,
0.021524377167224884,
-0.045742254704236984,
0.01574752666056156,
-0.006208046339452267,
-0.013798283413052559,
0.017448686063289642,
0.04165475070476532,
-0.006154885049909353,
0.007218108978122473,
-0.03173132613301277,
0.005413581617176533,
-0.004560049157589674,
0.04193827509880066,
-0.008222265169024467,
-0.004034344106912613,
-0.010537730529904366,
-0.0025561675429344177,
-0.00815728958696127,
-0.017909415066242218,
-0.04576588049530983,
0.007513448596000671,
-0.021335359662771225,
-0.00005491477713803761,
0.0041258991695940495,
-0.004577769432216883,
-0.014129064045846462,
0.03151868283748627,
-0.05292492359876633,
0.0024217877071350813,
-0.00428538303822279,
0.010189228691160679,
0.021973293274641037,
0.03808704391121864,
-0.023260975256562233,
0.011506444774568081,
-0.007212202064692974,
0.029415860772132874,
-0.033007193356752396,
-0.013904605992138386,
0.00815728958696127,
-0.013231230899691582,
-0.02754931151866913,
0.039055757224559784,
0.02034301683306694,
-0.025753645226359367,
0.008511697873473167,
-0.013054026290774345,
0.010709026828408241,
0.016042867675423622,
-0.037850771099328995,
0.01353838387876749,
0.007791068404912949,
0.030549965798854828,
-0.00022501213243231177,
0.023260975256562233,
-0.03962280973792076,
0.01363289263099432,
-0.03071535751223564,
-0.01351475715637207,
-0.005165495909750462,
-0.0069759301841259,
-0.025588255375623703,
0.016444530338048935,
0.002392253838479519,
0.004902643617242575,
0.059351518750190735,
0.008440816774964333,
0.003422990208491683,
0.04049701616168022,
-0.020307576283812523,
-0.013160348869860172,
0.02998291328549385,
-0.021099086850881577,
0.008984241634607315,
0.016350021585822105,
0.032723668962717056,
-0.003836466232314706,
0.030620848760008812,
0.0038807671517133713,
-0.02445415034890175,
0.002412927569821477,
-0.017980298027396202,
0.01264055073261261,
-0.022020548582077026,
0.020851001143455505,
0.11170939356088638,
-0.017330549657344818,
-0.015818409621715546,
0.022847499698400497,
-0.01579478196799755,
-0.008629834279417992,
0.011701369658112526,
-0.006010168232023716,
0.034259434789419174,
-0.012510601431131363,
0.013597452081739902,
0.02993565984070301,
0.03128241002559662,
0.007661118637770414,
0.033881399780511856,
0.0018798388773575425,
0.019362488761544228,
0.03144780173897743,
0.0029770268592983484,
0.005711874924600124,
0.007212202064692974,
0.012463347055017948,
0.0013002342311665416,
0.01981140486896038,
-0.022788431495428085,
0.0007542244275100529,
0.005847731605172157,
0.0015682552475482225,
0.0015933591639623046,
-0.01874818094074726,
0.01460160780698061,
0.010325085371732712,
-0.0016804843908175826,
-0.007820602506399155,
0.008718435652554035,
-0.03166044503450394,
-0.016149189323186874,
-0.020035862922668457,
0.0053131659515202045,
-0.0011045715073123574,
0.0016863911878317595,
0.01441259030252695,
-0.0054342555813491344,
-0.007194481790065765,
0.018901757895946503,
0.0042883362621068954,
-0.006491572596132755,
-0.004223361611366272,
0.007342151831835508,
-0.0212172232568264,
-0.0028101596981287003,
-0.012888636440038681,
-0.001718878629617393,
-0.016361834481358528,
-0.042599838227033615,
-0.015097779221832752,
0.010709026828408241,
-0.007099973037838936,
0.0016982047818601131,
-0.023402739316225052,
-0.010933485813438892,
0.00867118127644062,
0.01273505948483944,
-0.002888424787670374,
0.010614518076181412
] | 2024-07-04 | 241 | 38962014 | [
"CAR therapies",
"conventional CAR concepts",
"versatile adapter CAR concepts",
"CAR manufacturing",
"CAR",
"T cell therapy",
"Advanced CAR technologies",
"universal CAR technologies",
"elucidate strategic approaches",
"recent transformative next-generation CAR design",
"target antigen heterogeneity",
"BCMA-CAR T therapies",
"pivotal challenges",
"high expectations",
"multitargeted immunotherapies",
"Chimeric antigen receptor",
"advanced relapsed and refractory hematological cancers",
"patient-individualized treatment regimens",
"combinatorial",
"conjunction",
"CD19-",
"hematology",
"BCMA-CAR",
"oncology",
"the fundamental prerequisites",
"B-lineage malignancies",
"a collective aspiration",
"the future establishment",
"this comprehensive review",
"These groundbreaking successes"
] | [
"CAR (chimeric antigen receptor) T-cell therapy",
"antibody therapies",
"cancer immune cell therapy",
"iPSC (induced pluripotent stem cell)",
"individualized cancer therapy"
] | 0 | 10.3389/fimmu.2024.1383894
10.1126/science.342.6165.1432
10.1016/j.ebiom.2020.102931
10.3390/jcm11082158
10.3389/fimmu.2023.1063838
10.1136/jitc-2020-002173
10.1136/jitc-2023-006699
10.1182/blood-2017-05-781351
10.1016/j.ymthe.2019.04.010
10.33696/cancerimmunol
10.1074/jbc.M806889200
10.1158/2159-8290.CD-19-0945
10.1615/CritRevImmunol.v39.i1
10.4049/jimmunol.1701118
10.1101/cshperspect.a035055
10.1038/ni.3640
10.1073/pnas.1001169107
10.4049/jimmunol.1402346
10.3390/cells11020269
10.1080/2162402X.2021.2003532
10.1016/j.immuni.2016.01.021
10.1200/JCO.20.01467
10.3389/fimmu.2022.886546
10.1182/blood-2017-08-752121
10.1182/bloodadvances.2021006262
10.1186/s40364-022-00359-3
10.1038/s41551-022-00969-0
10.1016/j.omtm.2016.12.006
10.3389/fimmu.2021.780442
10.1182/bloodadvances.2022007103
10.1016/j.bbmt.2018.08.024
10.1038/s41467-022-32866-0
10.1111/bjh.18831
10.1182/blood-2022-165613
10.1182/blood.2021015209
10.1016/j.jtct.2023.03.012
10.1016/j.bbmt.2016.09.002
10.1182/blood-2013-02-486324
10.1007/s40262-017-0573-x
10.4049/jimmunol.173.10.6200
10.1038/cr.2016.142
10.1517/14712598.2011.592824
10.1038/s41587-020-0601-5
10.1182/blood-2018-99-111356
10.3389/fimmu.2023.1176724
10.1182/blood-2023-190357
10.3390/ijms232112828
10.20944/preprints202005.0259.v1
10.3390/cancers13081926
10.1007/s11095-021-03067-z
10.1038/s41467-018-04252-2
10.1007/s10529-016-2064-9
10.1038/nature21405
10.3390/v13071288
10.1038/s41587-020-0561-9
10.1182/blood.2022016205
10.1038/nbt.2623
10.1182/blood.2021010813
10.1016/j.stem.2023.02.009
10.1186/s13045-018-0677-2
10.3390/cancers12051302
10.1186/s13045-019-0763-0
10.1073/pnas.1524155113
10.1182/blood.V126.23.5549.5549
10.1158/2767-9764.CRC-21-0150
10.1182/blood-2019-130654
10.3390/biomedicines10102420
10.1038/mt.2016.141
10.1158/0008-5472.CAN-13-1365
10.1136/jitc-2022-005054
10.1158/1078-0432.CCR-12-1449
10.1080/2162402X.2017.1368604
10.4161/onci.19730
10.1182/blood-2023-177867
10.1182/blood-2021-151727
10.1021/jacs.9b11622
10.1038/s41467-023-37863-5
10.1186/s12967-014-0347-2
10.1158/1078-0432.CCR-18-3927
10.1182/blood-2022-162393
10.1097/CJI.0000000000000169
10.1056/NEJMoa1707447
10.3324/haematol.2017.183459
10.1200/JCO.19.03237
10.1038/s41571-020-0427-6
10.1056/NEJMoa2024850
10.3389/fimmu.2022.1050522
10.1002/ajh.26472
10.1056/NEJMoa2210859
10.1038/s41586-022-04489-4
10.1158/2159-8290.CD-21-0407
10.3389/fimmu.2024.1325860
10.1038/s41591-024-02893-z
10.1016/j.ccell.2019.09.006
10.1056/NEJMoa2213614
10.1038/s41591-019-0564-6
10.1016/j.addr.2022.114421
10.1182/blood-2014-12-580068
10.1016/j.csbj.2016.09.003
10.1136/jitc-2023-008566
10.1056/NEJMoa1407222
10.1038/s41591-019-0549-5
10.1038/sj.cgt.7700703
10.1038/s41591-021-01621-1
10.3390/cancers8030036
10.1016/S0167-5699(98)01346-2
10.1111/all.15104
10.1038/nri3567
10.1016/j.tcb.2020.06.003
10.1111/j.1365-3083.2009.02308.x
10.20900/immunometab20210030
10.1200/JCO.21.01536
10.1080/2162402X.2019.1593806
10.3389/fimmu.2022.876339
10.1158/2159-8290.CD-22-1276
10.1038/s41586-024-07242-1
10.1016/j.tim.2022.12.008
10.1056/NEJMra2026131
10.1172/JCI85309
10.1016/S0140-6736(14)61403-3
10.1186/s40364-021-00332-6
10.1038/s41571-021-00476-2
10.3390/cells9051225
10.1016/j.jtbi.2015.10.016
10.3389/fimmu.2020.01941
10.1158/2326-6066.CIR-18-0466
10.1186/s12967-018-1384-z
10.1186/s40364-023-00509-1
10.1038/s41423-020-0470-3
10.1038/s41587-022-01420-0
10.1097/PPO.0000000000000027
10.1186/s13045-019-0758-x
10.1038/mt.2013.262
10.3390/ijms20061283
10.1158/2159-8290.CD-15-1020
10.1158/2159-8290.CD-20-0756
10.1016/j.omto.2020.07.005
10.3389/fimmu.2022.947648
10.1016/S1470-2045(15)00248-X
10.1016/j.ejca.2023.02.019
10.20944/preprints202304.0482.v1
10.1038/s41591-018-0006-x
10.1001/jamaoncol.2017.0184
10.1038/s41571-022-00704-3
10.1182/bloodadvances.2021004603
10.1016/j.blre.2018.11.002
10.1126/scitranslmed.aac5415
10.1056/NEJMc2107725
10.1038/s41375-021-01232-2
10.1136/jitc-2021-003149
10.1126/scitranslmed.adi1145
10.1016/j.ymthe.2017.03.010
10.1093/neuonc/noad073.315
10.1200/JCO.2022.40.6_suppl.384
10.1056/NEJMoa1610497
10.1038/s42003-020-1097-8
10.1186/s13046-021-02215-y
10.1111/j.1600-065X.2009.00768.x
10.1038/mt.2010.24
10.1007/s00018-021-04089-x
10.1038/s41598-017-14749-3
10.1158/0008-5472.CAN-15-0159
10.1038/s41591-018-0290-5
10.1186/s13045-018-0646-9
10.1093/immadv/ltab018
10.1016/j.beha.2018.03.003
10.1182/blood.2022017414
10.1186/s40425-018-0343-9
10.1038/s41577-021-00547-6
10.3389/fonc.2020.00885
10.3389/fimmu.2022.879608
10.3389/fimmu.2020.577027
10.1002/ccr3.5209
10.1007/s40272-019-00367-1
10.1038/nrrheum.2015.179
10.1016/j.omto.2022.03.009
10.1016/j.cub.2020.06.081
10.1016/j.ebiom.2022.103941
10.1038/leu.2014.84
10.1038/nature04444
10.1182/blood-2008-12-195792
10.1172/jci.insight.133977
10.1007/s00262-018-2281-2
10.1016/j.tranon.2021.101085
10.1038/nbt.4195
10.1158/0008-5472.CAN-15-2524
10.3390/ijms22168706
10.2147/BTT.S291768
10.1038/s41598-022-16616-2
10.3389/fmolb.2021.675179
10.1016/j.omto.2017.12.003
10.1084/jem.180.1.211
10.1073/pnas.0407522101
10.1371/journal.pone.0046241
10.2174/1568009617666170427102729
10.1007/s00262-012-1202-z
10.3389/fimmu.2022.839783
10.3389/fimmu.2021.751138
10.3390/ijms19113455
10.1038/s42003-023-04978-w
10.1126/scitranslmed.abb6295
10.1182/blood.2020009759
10.1016/S0140-6736(13)60313-X
10.1634/theoncologist.2007-0201
10.1182/blood-2018-99-111622
10.1182/blood-2022-167194
10.1126/scitranslmed.abc6401
10.1182/blood.2021012634
10.1007/s11864-023-01049-4
10.3389/fimmu.2023.1140541
10.1056/NEJMoa2201445
10.1016/j.xcrm.2022.100543
10.3390/ijms19020340
10.1136/jitc-2020-001875
10.1007/s00262-008-0518-1
10.1007/s13311-020-00864-z
10.1345/aph.1P197
10.1016/j.neuropharm.2016.03.014
10.1016/j.addr.2008.04.012
10.1136/jitc-2022-005934
10.1016/j.stem.2023.02.004
10.1016/j.stemcr.2015.07.011
10.1073/pnas.2200626120
10.1208/s12248-009-9157-5
10.1200/EDBK_200773
10.1038/s41591-022-01960-7
10.3390/ijms23010405
10.1016/j.coi.2019.04.009
10.1038/s41577-020-0306-5
10.1126/scitranslmed.abm1463
10.1038/s41551-021-00842-6
10.3390/cancers15041003
10.1097/HS9.0000000000000524
10.1007/s00005-021-00640-7 | [
"Schlegel",
"Werbrouck",
"Boettcher",
"Schlegel"
] | [
"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.",
"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.",
"Department of Pediatric Surgery, University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany.",
"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.\nDepartment of Pediatric Hematology and Oncology, Westmead Children's Hospital, Sydney, NSW, Australia."
] | [
"38962014",
"24357284",
"32739874",
"35456250",
"29385370",
"36875091",
"33795386",
"37399355",
"29284597",
"31043341",
"35128536",
"19010777",
"32193224",
"31679192",
"29330322",
"31570335",
"27941787",
"20194792",
"25520398",
"35053386",
"35686214",
"36228643",
"26885860",
"33021872",
"35677038",
"29358181",
"35446932",
"35365224",
"36509913",
"28344995",
"34899742",
"35819448",
"30172015",
"36064867",
"37096915",
"35316325",
"36933659",
"27638367",
"23610374",
"28669130",
"15528357",
"27910851",
"33488631",
"21702703",
"32661440",
"37153585",
"36361619",
"32498368",
"33923528",
"34114161",
"29765029",
"29995861",
"37714135",
"26892225",
"28225754",
"34372494",
"32572269",
"36327161",
"23792628",
"34010392",
"36948187",
"30482221",
"32455621",
"31272471",
"26759369",
"27518241",
"36874404",
"36289682",
"27380762",
"24197131",
"35902133",
"23032741",
"29296519",
"22934280",
"38659225",
"29706540",
"32191035",
"37160880",
"25496493",
"31285373",
"28441264",
"29226797",
"29419431",
"32298202",
"32978608",
"33626253",
"36618390",
"35045201",
"37018492",
"35130560",
"34266984",
"38487523",
"38480922",
"31715131",
"36762851",
"31501612",
"35809868",
"25999455",
"27761200",
"38325903",
"25317870",
"31477906",
"15153936",
"35027758",
"26999211",
"9864948",
"34559894",
"24336101",
"32624246",
"19751267",
"34621543",
"35353548",
"31143514",
"35493513",
"37249512",
"38278150",
"38600376",
"36635162",
"33264547",
"27111235",
"25319501",
"34863296",
"33633361",
"32429189",
"26546971",
"32849651",
"12525379",
"30890531",
"29368612",
"31707680",
"37403182",
"32451454",
"36008612",
"24667957",
"31221182",
"24213558",
"30875739",
"34312556",
"26516065",
"33334730",
"32802940",
"36172343",
"26433816",
"36966697",
"37345050",
"29662203",
"28426845",
"36418477",
"34587230",
"30528964",
"26333935",
"34347960",
"29017060",
"33833386",
"34531250",
"29856956",
"37651540",
"28366766",
"36259971",
"28029927",
"32665635",
"34991665",
"19426220",
"20179677",
"34966954",
"29085043",
"26330166",
"30559421",
"30103775",
"34604863",
"29909918",
"36989488",
"29907163",
"34002066",
"32670871",
"36081506",
"33391257",
"35028140",
"31732958",
"27009539",
"35434273",
"32810447",
"35301179",
"24569779",
"16382236",
"19423728",
"31999649",
"30523370",
"35314843",
"33813229",
"30102295",
"26979791",
"34445415",
"33883875",
"35869100",
"34179083",
"29367945",
"7516408",
"15536127",
"23029447",
"28460617",
"22274776",
"35401506",
"34804035",
"30400287",
"37277433",
"33408186",
"33624009",
"23615461",
"18305055",
"37898374",
"33762438",
"34496014",
"36701037",
"36949946",
"35660797",
"33277400",
"37165196",
"35492880",
"29364163",
"33833049",
"18408925",
"32378027",
"20807868",
"26972827",
"18541331",
"36521930",
"36868193",
"26321144",
"36853939",
"19924542",
"30231350",
"36097223",
"35008832",
"31170601",
"32433532",
"36350984",
"35190680",
"36831349",
"33880433",
"34897554"
] | [] | 7.922001 | 4.309081 |
38962002 | 767 | Engineering strategies to safely drive CAR T-cells into the future. | Chimeric antigen receptor (CAR) T-cell therapy has proven a breakthrough in cancer treatment in the last decade, giving unprecedented results against hematological malignancies. All approved CAR T-cell products, as well as many being assessed in clinical trials, are generated using viral vectors to deploy the exogenous genetic material into T-cells. Viral vectors have a long-standing clinical history in gene delivery, and thus underwent iterations of optimization to improve their efficiency and safety. Nonetheless, their capacity to integrate semi-randomly into the host genome makes them potentially oncogenic via insertional mutagenesis and dysregulation of key cellular genes. Secondary cancers following CAR T-cell administration appear to be a rare adverse event. However several cases documented in the last few years put the spotlight on this issue, which might have been underestimated so far, given the relatively recent deployment of CAR T-cell therapies. Furthermore, the initial successes obtained in hematological malignancies have not yet been replicated in solid tumors. It is now clear that further enhancements are needed to allow CAR T-cells to increase long-term persistence, overcome exhaustion and cope with the immunosuppressive tumor microenvironment. To this aim, a variety of genomic engineering strategies are under evaluation, most relying on CRISPR/Cas9 or other gene editing technologies. These approaches are liable to introduce unintended, irreversible genomic alterations in the product cells. In the first part of this review, we will discuss the viral and non-viral approaches used for the generation of CAR T-cells, whereas in the second part we will focus on gene editing and non-gene editing T-cell engineering, with particular regard to advantages, limitations, and safety. Finally, we will critically analyze the different gene deployment and genomic engineering combinations, delineating strategies with a superior safety profile for the production of next-generation CAR T-cell. | [
0.01848827302455902,
0.04505406320095062,
0.05178137868642807,
0.04927047714591026,
-0.04993373528122902,
-0.028093647211790085,
0.018144801259040833,
-0.005365270655602217,
-0.004938891623169184,
0.003331087063997984,
0.01844089850783348,
-0.05751380696892738,
-0.015408867970108986,
0.012720311060547829,
-0.0017558529507368803,
-0.05343952029943466,
0.0294201597571373,
-0.006389765068888664,
0.026506569236516953,
-0.006200263276696205,
0.03077036142349243,
0.03946375846862793,
0.007171460427343845,
0.01640375331044197,
-0.021188674494624138,
-0.019897693768143654,
0.030225543305277824,
0.03266537934541702,
-0.019447626546025276,
-0.03493940085172653,
0.013028251007199287,
-0.01840536668896675,
-0.007692590355873108,
-0.005631757900118828,
-0.01139971986413002,
0.06220397725701332,
0.04557519406080246,
-0.006822066381573677,
-0.012507121078670025,
0.0028795397374778986,
0.046972766518592834,
0.011571455746889114,
0.025487996637821198,
0.08977649360895157,
-0.06419374793767929,
0.017185447737574577,
-0.01895018294453621,
-0.0667046457529068,
-0.00424602534621954,
0.005243871361017227,
-0.03238112851977348,
-0.013051939196884632,
-0.03117305226624012,
0.021982213482260704,
-0.052728887647390366,
0.048749346286058426,
-0.04209309443831444,
-0.01640375331044197,
-0.009706047363579273,
0.001717360457405448,
0.03280750662088394,
-0.024102265015244484,
0.013004563748836517,
-0.014994332566857338,
-0.04105083644390106,
0.016012905165553093,
-0.06187235191464424,
-0.0005326038226485252,
-0.006354233715683222,
0.034323520958423615,
-0.005042525473982096,
-0.004213455133140087,
0.004935930483043194,
-0.01666431874036789,
0.038445185869932175,
-0.008598646149039268,
-0.002083039842545986,
0.027548829093575478,
-0.003976577427238226,
-0.025938063859939575,
0.047043830156326294,
-0.0010970380390062928,
0.004080211278051138,
-0.03249956667423248,
-0.030651923269033432,
-0.020170101895928383,
0.007876169867813587,
-0.022005900740623474,
-0.03972432389855385,
-0.033991891890764236,
-0.04917572811245918,
0.04185621812939644,
-0.03472621366381645,
0.059314075857400894,
-0.0027611011173576117,
0.03709498420357704,
-0.004891516175121069,
-0.04844140633940697,
0.03536577895283699,
0.024516800418496132,
0.038468874990940094,
0.02265731431543827,
-0.005865674000233412,
0.007840638980269432,
0.052539385855197906,
-0.018085582181811333,
-0.0632462352514267,
0.013632288202643394,
0.0246589258313179,
-0.011079935356974602,
0.05135499686002731,
-0.03529471904039383,
-0.004568770993500948,
0.06547288596630096,
-0.03804249316453934,
-0.04922310262918472,
-0.01461532898247242,
-0.01128128170967102,
0.00940402876585722,
0.021508459001779556,
-0.04007963836193085,
0.011417485773563385,
0.02731195278465748,
-0.025890689343214035,
-0.0023436048068106174,
-0.027477767318487167,
0.07428471744060516,
-0.004805648233741522,
-0.012211024761199951,
-0.050881244242191315,
0.034347210079431534,
0.021780867129564285,
0.02269284427165985,
-0.01646297238767147,
-0.07613236457109451,
-0.013952072709798813,
-0.02264546975493431,
0.025251120328903198,
-0.044911935925483704,
-0.0007483842200599611,
0.004296361934393644,
-0.02463523857295513,
-0.01664062961935997,
0.004918165039271116,
-0.02501424215734005,
-0.04396442696452141,
0.009066478349268436,
0.028188398107886314,
0.0010148711735382676,
0.04341960698366165,
-0.03110198862850666,
0.032167937606573105,
0.053155265748500824,
0.005578460171818733,
-0.025227433070540428,
-0.048938848078250885,
-0.019163373857736588,
0.07058943808078766,
-0.02487211674451828,
-0.042543161660432816,
-0.018298771232366562,
0.015136458911001682,
-0.030154479667544365,
-0.04827559366822243,
0.004536200314760208,
-0.05675579980015755,
-0.009670515544712543,
0.02716982550919056,
-0.05121287330985069,
-0.0228705033659935,
-0.019092310220003128,
-0.054908156394958496,
-0.04787290096282959,
-0.017280198633670807,
-0.025819625705480576,
-0.011056248098611832,
-0.013051939196884632,
0.007177382241934538,
-0.026222316548228264,
-0.03737923875451088,
-0.003212648443877697,
0.030628234148025513,
0.021934837102890015,
0.0032392970751971006,
-0.021745335310697556,
0.019352875649929047,
0.002386538777500391,
0.01139971986413002,
-0.03700023517012596,
-0.05334476754069328,
0.008000530302524567,
-0.015337805263698101,
0.044959310442209244,
-0.0001866334059741348,
0.009486936032772064,
0.006306858267635107,
0.04190359264612198,
0.02313106879591942,
0.006863519549369812,
-0.059361450374126434,
0.04557519406080246,
-0.02901746891438961,
-0.03877681493759155,
0.0031001316383481026,
-0.03958219662308693,
-0.04015070199966431,
-0.02257440611720085,
0.06428849697113037,
-0.015503618866205215,
0.008811835199594498,
0.04159565269947052,
-0.007189225871115923,
-0.006025566253811121,
0.023746948689222336,
-0.03188368305563927,
-0.02880427986383438,
0.009285589680075645,
0.04486456140875816,
0.02102285996079445,
0.012139961123466492,
-0.025440622121095657,
-0.016972258687019348,
-0.030722985044121742,
0.002211841754615307,
-0.010766073130071163,
-0.011541846208274364,
-0.011174686253070831,
-0.022195402532815933,
0.02253887429833412,
0.0015929997898638248,
-0.004989228211343288,
0.014283700846135616,
0.028496339917182922,
-0.060972217470407486,
-0.038018807768821716,
-0.014473202638328075,
0.0190567784011364,
-0.002473887288942933,
0.04420130327343941,
-0.007976843044161797,
0.01546808797866106,
0.009646828286349773,
0.01236499473452568,
-0.02253887429833412,
-0.019720034673810005,
0.00412462605163455,
-0.0166169423609972,
-0.08475469797849655,
0.02489580400288105,
0.005871595814824104,
-0.004710897337645292,
0.008503895252943039,
0.005391919519752264,
0.024327298626303673,
0.036763355135917664,
0.016237938776612282,
0.006608876399695873,
-0.015598369762301445,
0.030083416029810905,
-0.01665247417986393,
0.008959883823990822,
-0.02735932730138302,
-0.05827181413769722,
-0.02731195278465748,
-0.05775068700313568,
0.012057054787874222,
0.01455610990524292,
-0.0011718024034053087,
0.0083084711804986,
-0.02489580400288105,
0.040885020047426224,
0.009516545571386814,
0.014319232665002346,
-0.008912508375942707,
-0.0586034432053566,
0.023261351510882378,
0.006377921439707279,
0.029964977875351906,
0.009540232829749584,
0.022029587998986244,
-0.017126228660345078,
0.01842905394732952,
-0.007876169867813587,
-0.0027137254364788532,
-0.0228705033659935,
-0.018263239413499832,
-0.009729734621942043,
0.005933776497840881,
0.014757455326616764,
-0.04379861429333687,
0.032096873968839645,
0.014994332566857338,
-0.01662878692150116,
-0.02050173096358776,
0.01896202750504017,
0.022313840687274933,
0.014046823605895042,
0.020099038258194923,
-0.04735177010297775,
-0.013099314644932747,
-0.01365597639232874,
0.002226646523922682,
0.00203122291713953,
-0.027738330885767937,
-0.01143525168299675,
0.010292318649590015,
-0.022301997989416122,
-0.01352569367736578,
0.03155205771327019,
0.021567678079009056,
0.025487996637821198,
-0.010925965383648872,
0.030201856046915054,
-0.01240052655339241,
0.009569843299686909,
0.032333750277757645,
0.0102449432015419,
-0.0701630562543869,
0.02693294920027256,
-0.06201447546482086,
-0.03145730495452881,
0.011133233085274696,
-0.012921656481921673,
0.00912569835782051,
-0.0034258379600942135,
-0.03996120020747185,
0.03662123158574104,
-0.021780867129564285,
0.054766032844781876,
-0.007947233505547047,
0.004086133558303118,
-0.024102265015244484,
0.05680317431688309,
0.000377523188944906,
0.007645214907824993,
-0.015977373346686363,
-0.042566850781440735,
-0.028306836262345314,
0.01908046565949917,
-0.00734319631010294,
-0.029917603358626366,
0.029941290616989136,
-0.02873321622610092,
0.04349067062139511,
-0.017256511375308037,
-0.015574682503938675,
-0.007029333617538214,
0.029467536136507988,
-0.01628531515598297,
-0.006839831825345755,
-0.008349924348294735,
0.0024427971802651882,
0.014923269860446453,
0.0023746949154883623,
-0.008977649733424187,
0.03782930597662926,
-0.029609661549329758,
0.011683972552418709,
-0.006620720494538546,
-0.04829928278923035,
0.01687750779092312,
0.022041432559490204,
-0.027714643627405167,
0.03122042864561081,
0.05670842528343201,
0.05244463309645653,
-0.05230250582098961,
0.04780183732509613,
-0.006875363644212484,
-0.025724874809384346,
-0.038634687662124634,
-0.006851675920188427,
0.018239552155137062,
0.017801329493522644,
-0.024173328652977943,
0.022088808938860893,
0.021863775327801704,
0.015302273444831371,
0.02080967091023922,
0.004379269201308489,
0.029822852462530136,
0.00026870769215747714,
-0.03484465181827545,
-0.042495787143707275,
-0.011263515800237656,
0.02089257724583149,
0.021804554387927055,
-0.01049366407096386,
-0.074332095682621,
0.03446564823389053,
-0.030486108735203743,
-0.014544266276061535,
-0.006105512380599976,
-0.007562307640910149,
-0.014058667235076427,
0.07068418711423874,
-0.0329970084130764,
0.05855606868863106,
0.05595041811466217,
0.008036062121391296,
0.002245892770588398,
-0.07347933948040009,
-0.013549381867051125,
-0.029680725187063217,
0.028022583574056625,
-0.03970063477754593,
0.03754505142569542,
0.029728101566433907,
0.0294201597571373,
-0.030651923269033432,
-0.006259482819586992,
0.011518158949911594,
0.030817735940217972,
0.004426644649356604,
0.0017765797674655914,
-0.01555099431425333,
-0.021828243508934975,
0.03958219662308693,
0.007029333617538214,
0.04628582298755646,
0.030699297785758972,
-0.024516800418496132,
-0.0016773873940110207,
-0.015515463426709175,
-0.004799726419150829,
-0.02252703160047531,
0.004050601739436388,
0.034513022750616074,
0.014579798094928265,
-0.04521987587213516,
-0.023545604199171066,
0.05974045395851135,
0.0014101602137088776,
-0.03742661327123642,
-0.005910088773816824,
0.0420457199215889,
0.013881010003387928,
0.02923065796494484,
-0.01859486848115921,
0.05268150940537453,
-0.05628204718232155,
0.03986645117402077,
0.008113047108054161,
-0.014106042683124542,
0.046854328364133835,
-0.002607130678370595,
-0.01237683929502964,
0.0294201597571373,
-0.02276390790939331,
-0.02882796712219715,
-0.034252457320690155,
0.000289249379420653,
-0.0054008024744689465,
-0.030367670580744743,
-0.05585566535592079,
-0.011968225240707397,
0.019980600103735924,
-0.0817226693034172,
0.011849787086248398,
0.03380239009857178,
-0.001484184293076396,
-0.020181946456432343,
-0.003502822946757078,
-0.034205082803964615,
0.010031753219664097,
0.021153142675757408,
0.01632084511220455,
-0.015219366177916527,
-0.003795958822593093,
-0.02913590706884861,
0.015112771652638912,
-0.009510623291134834,
-0.023510072380304337,
0.012293932028114796,
-0.005788689013570547,
0.030083416029810905,
-0.003970655612647533,
0.0005633238470181823,
0.013632288202643394,
0.004595419391989708,
-0.011109544895589352,
0.00618841964751482,
0.0028366055339574814,
0.020383290946483612,
0.011251671239733696,
0.021390020847320557,
0.007941311225295067,
-0.023735105991363525,
-0.0050780572928488255,
0.019625283777713776,
-0.01036930363625288,
-0.01255449652671814,
0.002629338065162301,
-0.010357460007071495,
0.0015530268428847194,
0.016107656061649323,
-0.01897387206554413,
-0.0013672261266037822,
-0.034157708287239075,
0.007011568173766136,
-0.0026056503411382437,
0.048844099044799805,
-0.04396442696452141,
0.01864224299788475,
0.05955095216631889,
0.06007208302617073,
0.026317067444324493,
0.05557141453027725,
0.015266741625964642,
0.04330116882920265,
-0.028401587158441544,
-0.017836861312389374,
0.016095811501145363,
-0.00286473473533988,
-0.026009127497673035,
-0.02494318038225174,
-0.03662123158574104,
-0.0035798081662505865,
-0.0038847876712679863,
-0.02253887429833412,
0.002248853910714388,
-0.017374949529767036,
-0.0055044363252818584,
0.010837136767804623,
-0.006146966014057398,
-0.02925434708595276,
-0.03268906846642494,
-0.02075045183300972,
-0.019198905676603317,
-0.06409899890422821,
0.018322458490729332,
-0.005134315229952335,
0.0012502679601311684,
0.011666206642985344,
-0.03538946807384491,
-0.021105768159031868,
-0.019672660157084465,
0.04730439558625221,
-0.03529471904039383,
-0.005350465886294842,
-0.010327850468456745,
0.007260289043188095,
0.042566850781440735,
0.0014886257704347372,
-0.01641559600830078,
0.008290705271065235,
-0.007378727663308382,
-0.045977883040905,
0.030296606943011284,
-0.013205909170210361,
0.007195148151367903,
-0.040600769221782684,
0.011204295791685581,
-0.008799991570413113,
0.012003757059574127,
-0.021780867129564285,
-0.014567953534424305,
-0.027927832677960396,
-0.00834400299936533,
-0.019210748374462128,
-0.015752339735627174,
-0.009860017336905003,
0.02306000515818596,
-0.00827293936163187,
-0.0203714482486248,
0.02487211674451828,
-0.010600259527564049,
-0.015669433400034904,
-0.01672353781759739,
0.008231486193835735,
-0.031859997659921646,
-0.021295269951224327,
0.038563624024391174,
-0.010381147265434265,
0.038634687662124634,
0.044556621462106705,
-0.017067009583115578,
-0.006129200104624033,
-0.009149385616183281,
0.02712245099246502,
-0.014745611697435379,
-0.054813407361507416,
-0.0028884224593639374,
0.03515259176492691,
-0.007828794419765472,
0.013182221911847591,
-0.04747021198272705,
-0.011133233085274696,
-0.007651136722415686,
-0.005898244678974152,
0.0497916080057621,
0.012507121078670025,
0.014579798094928265,
0.008764459751546383,
-0.03375501558184624,
0.023652197793126106,
0.02461155131459236,
0.0025967673864215612,
-0.019530532881617546,
0.0025183018296957016,
-0.0023909802548587322,
-0.0020297423470765352,
-0.013300660066306591,
-0.026340754702687263,
-0.030343981459736824,
0.02937278524041176,
-0.005599187221378088,
-0.014733768068253994,
0.0125663410872221,
-0.01449689082801342,
0.03088879957795143,
0.01264924742281437,
-0.024244392290711403,
0.034347210079431534,
0.034347210079431534,
0.04142984002828598,
0.0052083395421504974,
-0.01868961937725544,
0.014899581670761108,
-0.036479104310274124,
0.00415719673037529,
-0.00131244829390198,
-0.003227453213185072,
-0.009007259272038937,
0.0034199159126728773,
-0.029964977875351906,
-0.0006969374371692538,
-0.021922994405031204,
0.026482881978154182,
-0.005329739302396774,
-0.0038522169925272465,
-0.03932163119316101,
-0.022183559834957123,
0.04349067062139511,
-0.0064312187023460865,
-0.02878059260547161,
0.038066182285547256,
-0.010766073130071163,
-0.006093668285757303,
0.002577521139755845,
-0.013170377351343632,
0.01886727660894394,
-0.009261902421712875,
-0.012116273865103722,
0.010316005907952785,
-0.02695663645863533,
-0.013904697261750698,
0.020253008231520653,
0.01871330663561821,
-0.008444675244390965,
-0.004201611038297415,
-0.02104654721915722,
0.030415045097470284,
-0.03200212121009827,
0.013442786410450935,
-0.015799716114997864,
0.009889626875519753,
-0.01236499473452568,
0.05547666177153587,
0.0615880973637104,
-0.01669984869658947,
0.010819370858371258,
-0.0005944139556959271,
-0.007811028975993395,
-0.005791650153696537,
0.002934317570179701,
0.016237938776612282,
0.010837136767804623,
-0.024469424039125443,
0.01028047502040863,
0.054955534636974335,
0.023971982300281525,
0.010985184460878372,
-0.028401587158441544,
-0.03131517767906189,
-0.002010496100410819,
0.017528919503092766,
-0.028472650796175003,
-0.0020001325756311417,
0.014236325398087502,
-0.0036301445215940475,
0.012613716535270214,
-0.05206562951207161,
-0.005945620127022266,
0.00466944370418787,
-0.004909282084554434,
0.010162035934627056,
0.016178719699382782,
0.009516545571386814,
-0.013158533722162247,
0.014271857216954231,
-0.001979405991733074,
-0.0381135568022728,
0.0003827048931270838,
0.03294963389635086,
0.038539934903383255,
-0.011944537982344627,
-0.011897162534296513,
-0.025772249326109886,
-0.046380575746297836,
0.03200212121009827,
0.05580829083919525,
0.021567678079009056,
-0.01153000257909298,
0.03541315719485283,
-0.006774690933525562,
-0.006567423231899738,
-0.025961751118302345,
0.011755036190152168,
0.03472621366381645,
0.014757455326616764,
-0.008130813017487526,
-0.03145730495452881,
-0.025511685758829117,
-0.010126504115760326,
-0.010730541311204433,
-0.0002875838545151055,
0.014248169958591461,
0.008415065705776215,
0.013904697261750698,
-0.0047523509711027145,
0.027572518214583397,
-0.03188368305563927,
0.0003801140410359949,
0.009196761064231396,
0.04801502823829651,
-0.027927832677960396,
0.06964192539453506,
-0.02939647249877453,
-0.013194065541028976,
-0.012199181132018566,
-0.040671832859516144,
-0.01558652613312006,
0.010854901745915413,
-0.010452210903167725,
0.03572109714150429,
-0.020087195560336113,
-0.02925434708595276,
-0.012211024761199951,
0.006330545991659164,
0.017339417710900307,
-0.014058667235076427,
0.0016507386462762952,
0.03309175744652748,
-0.023545604199171066,
0.021295269951224327,
0.040553394705057144,
-0.005338622257113457,
0.016036592423915863,
-0.027619892731308937,
0.009190838783979416,
0.008521661162376404,
-0.030036041513085365,
-0.04555150493979454,
0.0007561567472293973,
-0.013194065541028976,
0.0020238205324858427,
-0.0019646009895950556,
-0.021188674494624138,
-0.02726457640528679,
-0.015361492522060871,
0.005868635140359402,
0.006887207273393869,
0.028638465330004692,
0.001889096456579864,
-0.007426103111356497,
0.01860671117901802,
0.02501424215734005,
-0.01854749210178852,
0.03512890264391899,
-0.0269803237169981,
-0.011174686253070831,
-0.020276697352528572,
-0.021164987236261368,
-0.012874281033873558,
0.013217752799391747,
0.0011384915560483932,
0.020134570077061653,
-0.02887534350156784,
0.015361492522060871,
-0.001174763310700655,
0.01624978333711624,
-0.03339969739317894,
0.006049253977835178,
-0.013182221911847591,
-0.022100651636719704,
-0.007651136722415686,
0.030367670580744743,
-0.02249149978160858,
-0.02053726091980934,
-0.009475091472268105,
0.012897969223558903,
-0.024208860471844673,
0.016261626034975052,
-0.03332863748073578,
0.013111158274114132,
0.034252457320690155,
-0.06841016560792923,
-0.012957188300788403,
0.038184620440006256,
0.005465943831950426,
0.010221255011856556,
0.004811570048332214,
-0.0290648452937603,
0.0010933367302641273,
0.03110198862850666,
-0.0229889415204525,
-0.0033932672813534737,
-0.034489333629608154,
0.022183559834957123,
-0.013194065541028976,
-0.003313321154564619,
-0.017232824116945267,
-0.019874004647135735,
-0.06078271567821503,
-0.004725702106952667,
0.009522467851638794,
-0.002006054623052478,
0.008705240674316883,
-0.02264546975493431,
0.03536577895283699,
0.0030305490363389254,
0.008201876655220985,
-0.007633370812982321,
-0.019885849207639694,
-0.0497916080057621,
-0.012862437404692173,
-0.019885849207639694,
0.018215864896774292,
-0.019305499270558357,
0.030580859631299973,
-0.0043674251064658165,
-0.04079027101397514,
0.025677498430013657,
-0.019115997478365898,
-0.0008609009091742337,
0.0013191105099394917,
0.019435781985521317,
0.008320314809679985,
0.026009127497673035,
0.017043322324752808,
-0.024350985884666443,
-0.0052083395421504974,
-0.028046272695064545,
0.0027596205472946167,
0.018014518544077873,
-0.01687750779092312,
0.027998896315693855,
-0.032475877553224564,
-0.032310064882040024,
-0.01654587872326374,
-0.011222061701118946,
-0.010564727708697319,
-0.006679940037429333,
0.04758865013718605,
0.03470252454280853,
0.01680644415318966,
-0.00679837865754962,
0.054955534636974335,
0.049033600836992264,
-0.03453671187162399,
-0.004331893753260374,
-0.01842905394732952,
-0.038468874990940094,
0.030367670580744743,
-0.040600769221782684,
0.02084520272910595,
-0.01690119504928589,
0.013904697261750698,
-0.04012701287865639,
0.026127565652132034,
-0.02046619914472103,
-0.0031356632243841887,
0.004947774577885866,
-0.017386794090270996,
0.001595960813574493,
0.006922739092260599,
-0.02707507461309433,
-0.025582747533917427,
-0.01339541096240282,
0.011743191629648209,
-0.03989013656973839,
0.01633268967270851,
0.0017780602211132646,
0.0008845886331982911,
0.022337529808282852,
-0.016226094216108322,
0.0076807462610304356,
-0.024197015911340714,
0.0015500658191740513,
0.0041749621741473675,
0.006055175792425871,
-0.036242228001356125,
-0.04126402363181114,
0.005190573632717133,
-0.014248169958591461,
-0.017303885892033577,
0.03586322441697121,
-0.03268906846642494,
-0.009652749635279179,
-0.048701971769332886,
-0.0497916080057621,
0.008059750311076641,
0.023225819692015648,
-0.015610214322805405,
-0.004808609373867512,
-0.015752339735627174,
0.018180333077907562,
0.021449239924550056,
-0.0008660826133564115,
-0.0049714623019099236,
0.016107656061649323,
0.01677091233432293,
0.01236499473452568,
-0.0204898864030838,
0.013478318229317665,
0.007088553160429001,
0.07068418711423874,
0.015953686088323593,
-0.031978435814380646,
-0.012074820697307587,
-0.0018742915708571672,
-0.015349648892879486,
0.009451404213905334,
0.004770116414874792,
0.004657600075006485,
-0.021449239924550056,
0.010286396369338036,
0.003212648443877697,
0.02458786405622959,
0.023865388706326485,
-0.019779253751039505,
0.042803727090358734,
0.0025375480763614178,
0.020158257335424423,
-0.010167958214879036,
0.021212361752986908,
-0.005442256107926369,
-0.0294201597571373,
0.0038403731305152178,
-0.01879621297121048,
0.034347210079431534,
-0.0013931345893070102,
-0.04332485795021057,
0.019127842038869858,
-0.027383016422390938,
0.01543255615979433,
-0.040458641946315765,
0.031931061297655106,
0.021603209897875786,
0.055239785462617874,
0.0026056503411382437,
0.011832021176815033,
0.032286375761032104,
-0.00009373308421345428,
-0.02889903075993061,
0.017422325909137726,
-0.015870779752731323,
0.05249200761318207,
-0.025890689343214035,
-0.014769299887120724,
0.02302447333931923,
-0.0028543714433908463,
0.011755036190152168,
0.003449525684118271,
0.03702392056584358,
0.0307940486818552,
0.002932837000116706,
-0.04815715551376343,
0.04792027920484543,
-0.0004319309373386204,
-0.02679082192480564,
0.02892271801829338,
0.036242228001356125,
0.017517076805233955,
0.02499055489897728,
0.032452188432216644,
-0.02899378165602684,
-0.022195402532815933,
0.007426103111356497,
0.03745030239224434,
0.011630675755441189,
-0.011482627131044865,
-0.02083335816860199,
-0.029562287032604218,
0.02073860727250576,
0.005809415597468615,
-0.02934909798204899,
-0.017552608624100685,
0.013892853632569313,
0.054955534636974335,
-0.0017395676113665104,
0.001142192748375237,
-0.017422325909137726,
-0.014165262691676617,
-0.02468261495232582,
-0.025369558483362198,
-0.06177759915590286,
0.014236325398087502,
0.04015070199966431,
0.0008475765935145319,
-0.011079935356974602,
0.012542652897536755,
0.011843864805996418,
-0.025345871224999428,
0.019388407468795776,
0.040340203791856766,
0.013987604528665543,
0.05827181413769722,
-0.03749767690896988,
0.02308369241654873,
-0.0062535605393350124,
-0.004921125713735819,
0.025890689343214035,
0.017327575013041496,
-0.044911935925483704,
-0.016119500622153282,
-0.06348311901092529,
-0.025961751118302345,
-0.003798919729888439,
-0.01847642846405506,
-0.012909812852740288,
-0.0037811538204550743,
-0.000686944171320647,
0.030367670580744743,
0.0042785960249602795,
0.0029061883687973022,
-0.030012354254722595,
0.0029594856314361095,
0.03524734079837799,
-0.006377921439707279,
0.005234988406300545,
-0.007538619916886091,
0.0017454895423725247,
-0.02270468883216381,
0.008142657577991486,
-0.008604567497968674,
0.05130762234330177,
0.022361217066645622,
0.018204020336270332,
-0.03538946807384491,
-0.013644132763147354,
-0.0025997282937169075,
0.05561878904700279,
-0.0266250092536211,
0.013217752799391747,
-0.012625560164451599,
-0.03780561685562134,
0.007876169867813587,
0.03870575129985809,
0.022408591583371162,
0.06727315485477448,
0.014094199053943157,
0.009563921019434929,
0.0019823668990284204,
0.004314127843827009,
-0.013644132763147354,
0.008089359849691391,
-0.0101857241243124,
0.02243228070437908,
-0.0077873412519693375,
0.03294963389635086,
-0.009954768233001232,
0.000918639765586704,
-0.018381677567958832,
0.027785707265138626,
0.015574682503938675,
0.027288265526294708,
0.03131517767906189,
-0.006052215117961168,
0.01648665964603424,
-0.01331250462681055,
0.0058271815069019794,
0.01155961211770773,
0.004548043943941593,
-0.03354182466864586,
0.0036271836142987013,
-0.01552730705589056,
-0.009036868810653687,
-0.03510521724820137,
-0.0066503300331532955,
0.003541315672919154,
0.014816675335168839,
-0.010067285038530827,
-0.00846244115382433,
0.008930274285376072,
-0.0035946129355579615,
-0.02097548544406891,
0.007319508586078882,
-0.026482881978154182,
-0.025345871224999428,
-0.025322183966636658,
-0.026553945615887642,
0.012104430235922337,
0.02731195278465748,
-0.014224481768906116,
0.004826374817639589,
0.03266537934541702,
0.03344707563519478,
0.011074014008045197,
-0.01884358935058117,
0.02109392359852791,
-0.01161883119493723,
-0.014508734457194805,
-0.03960588574409485,
0.04834665730595589,
-0.005744274705648422,
-0.04389336332678795,
0.010387069545686245,
-0.0011429329169914126,
-0.007864326238632202,
0.03261800482869148,
0.00470201438292861,
-0.03167049586772919,
0.003413994098082185,
0.014485047198832035,
0.029562287032604218,
-0.021982213482260704,
-0.008681553415954113,
0.00339622818864882,
-0.017149915918707848,
-0.010019909590482712,
-0.0228705033659935,
0.008012374863028526,
-0.003970655612647533,
-0.025582747533917427,
-0.02265731431543827,
0.024137796834111214,
-0.015041708014905453,
0.013821789994835854,
0.0031889607198536396,
0.01836983487010002,
0.006756925024092197,
0.007710356265306473,
-0.019731879234313965,
-0.0004700533754657954,
0.01857117936015129,
-0.00207711779512465,
0.005539967678487301,
0.01145893894135952,
0.03470252454280853,
0.014899581670761108,
-0.010813448578119278,
-0.017043322324752808,
-0.0028425275813788176,
-0.024208860471844673,
-0.00014416204066947103,
0.05647154897451401,
-0.00418976740911603,
-0.026246003806591034,
0.054766032844781876,
0.01842905394732952,
-0.011287203058600426,
0.0025508725084364414,
0.007509010378271341,
-0.002658947603777051,
-0.012933500111103058,
-0.021579522639513016,
0.02083335816860199,
0.023427164182066917,
-0.012175492942333221,
-0.000034351833164691925,
0.008041984401643276,
-0.01701963320374489,
-0.021650584414601326,
-0.014200793579220772,
-0.002262178109958768,
0.01854749210178852,
0.009966612793505192,
-0.044509243220090866,
0.009575764648616314,
0.004980345256626606,
0.019459469243884087,
0.050975993275642395,
0.013513850048184395,
0.008077516220510006,
0.019305499270558357,
0.006069980561733246,
-0.00812489166855812,
0.010120582766830921,
-0.019364718347787857,
-0.0008194473921321332,
-0.008616412058472633,
-0.03505783900618553,
-0.04725702106952667,
0.014307389035820961,
0.0036804811097681522,
-0.01039891317486763,
-0.0227520652115345,
0.009623140096664429,
-0.01642744056880474,
-0.01240052655339241,
-0.009113853797316551,
-0.02058463729918003,
-0.01136418804526329,
-0.016131343320012093,
-0.00518465181812644,
-0.026340754702687263,
0.0029254346154630184,
0.013999448157846928,
-0.01685382053256035,
0.0046487171202898026,
0.000041152805351885036,
0.006839831825345755,
-0.0021067275665700436,
0.01685382053256035,
0.005895283538848162,
-0.03593428432941437,
0.002351007191464305,
-0.061209093779325485,
0.008012374863028526,
-0.04628582298755646,
-0.0004826374934054911,
-0.0026530257891863585,
-0.023782480508089066,
-0.02065570093691349,
0.005957464221864939,
0.013798102736473083,
0.004429605323821306,
0.0069582704454660416,
0.005066213198006153,
0.006537813227623701,
-0.013513850048184395,
0.01665247417986393,
0.006348311435431242,
-0.04730439558625221,
0.028448963537812233,
-0.011630675755441189,
0.001905381795950234,
-0.005024759564548731,
0.010671322233974934,
-0.03553159534931183,
0.02252703160047531,
0.018050050362944603,
0.016972258687019348,
-0.012187336571514606,
0.011766879819333553,
-0.004103899002075195,
-0.010807526297867298,
0.05220775678753853,
0.021425550803542137,
-0.011772802099585533,
-0.01543255615979433,
-0.013857321813702583,
-0.002226646523922682,
0.002610091818496585,
0.044746123254299164,
0.034015581011772156,
0.04015070199966431,
-0.02477736584842205,
-0.007769575342535973,
-0.014413983561098576,
-0.011606987565755844,
-0.034347210079431534,
-0.022005900740623474,
0.0051520811393857,
0.023308726027607918,
-0.03747398778796196,
-0.0033903063740581274,
-0.013123001903295517,
0.02111761085689068,
-0.007497166283428669,
0.013809946365654469,
-0.009575764648616314,
-0.011826098896563053,
0.006037410348653793,
-0.025914376601576805,
0.005421529058367014,
0.005587343126535416,
0.015160147100687027,
0.019471313804388046,
0.02496686764061451,
-0.04635688662528992,
0.038516249507665634,
0.004548043943941593,
0.025795938447117805,
-0.034157708287239075,
-0.022159870713949203,
0.011944537982344627,
0.006976036354899406,
-0.016072124242782593,
0.015349648892879486,
0.034205082803964615,
-0.017161760479211807,
-0.028117334470152855,
0.034062955528497696,
-0.028472650796175003,
-0.0188791211694479,
-0.02259809337556362,
-0.015693120658397675,
-0.006401609163731337,
-0.023687729611992836,
-0.0002942460123449564,
0.013016407378017902,
0.000179416048922576,
-0.000798720633611083,
-0.016107656061649323,
-0.008669708855450153,
0.00912569835782051,
0.005613991990685463,
-0.0037870758678764105,
0.007911701686680317,
0.011162842623889446,
-0.050644367933273315,
-0.09669331461191177,
0.026317067444324493,
-0.0025449504610151052,
-0.020027976483106613,
-0.004130547866225243,
-0.011790567077696323,
0.010120582766830921,
0.05121287330985069,
-0.059598326683044434,
0.010908199474215508,
0.026388131082057953,
0.004992188885807991,
0.016072124242782593,
-0.012933500111103058,
-0.01449689082801342,
0.023664042353630066,
0.0007890975102782249,
0.006887207273393869,
-0.012353151105344296,
0.013182221911847591,
0.036384351551532745,
-0.013229597359895706,
0.013549381867051125,
0.03958219662308693,
0.014046823605895042,
0.00721883587539196,
0.00012473070819396526,
-0.03380239009857178,
0.03782930597662926,
-0.03543684259057045,
-0.012980875559151173,
-0.022420436143875122,
-0.01685382053256035,
-0.007585995364934206,
-0.010541039519011974,
0.03150467947125435,
-0.015207522548735142,
0.0070648654364049435,
-0.00044710590736940503,
0.0329970084130764,
-0.01688935048878193,
-0.021650584414601326,
0.0166761614382267,
0.015598369762301445,
0.006514125503599644,
0.00831439346075058,
0.005960424896329641,
-0.022041432559490204,
-0.02527480758726597,
0.003825568361207843,
-0.02249149978160858,
-0.006810222286731005,
0.01449689082801342,
0.007118162699043751,
-0.017351262271404266,
0.02279943972826004,
-0.003603495890274644,
0.008640099316835403,
-0.021307112649083138,
-0.021200519055128098,
-0.021247893571853638,
-0.008811835199594498,
-0.012732154689729214,
-0.009552077390253544,
-0.004562849178910255,
-0.025677498430013657,
0.02475367859005928,
-0.026127565652132034,
0.02249149978160858,
0.010458133183419704,
0.01359675731509924,
0.014307389035820961,
-0.00930335558950901,
-0.028377899900078773,
0.012317619286477566,
-0.01552730705589056,
0.02070307545363903,
-0.03718973696231842,
-0.00840914435684681,
-0.025938063859939575,
-0.010760150849819183,
-0.012850593775510788,
0.01834614761173725,
-0.04353804886341095,
0.026032814756035805,
-0.0014427307760342956,
0.0056968992576003075,
0.005101745016872883,
0.05263413488864899,
-0.0075800735503435135,
0.005166885908693075,
-0.038445185869932175,
-0.008225563913583755,
0.023190287873148918,
0.03321019560098648,
-0.014946957118809223,
-0.025772249326109886,
-0.012886124663054943,
-0.02097548544406891,
-0.000952690897975117,
-0.04301691800355911,
-0.03550790622830391,
0.003177116857841611,
-0.01664062961935997,
-0.011002950370311737,
0.009617218747735023,
-0.017789484933018684,
-0.008675631135702133,
0.0291832834482193,
-0.027572518214583397,
-0.002920993138104677,
-0.02731195278465748,
0.017777640372514725,
0.03140993043780327,
0.04171409085392952,
-0.02489580400288105,
0.012282087467610836,
0.02295340970158577,
0.03332863748073578,
-0.00922044925391674,
0.0015767145669087768,
0.0307940486818552,
-0.026435505598783493,
-0.017280198633670807,
0.029633350670337677,
0.010167958214879036,
-0.0290648452937603,
0.016237938776612282,
-0.008065671660006046,
-0.024078577756881714,
0.02111761085689068,
-0.03773455321788788,
0.017836861312389374,
-0.0027611011173576117,
0.014852206222712994,
0.02065570093691349,
0.042685288935899734,
-0.04351435974240303,
0.012211024761199951,
-0.03294963389635086,
0.002025300869718194,
-0.00942771602421999,
0.0005448177689686418,
-0.03496308997273445,
0.0291832834482193,
0.017493387684226036,
0.011387876234948635,
0.027880458161234856,
0.011014793999493122,
0.001597441267222166,
-0.005791650153696537,
-0.002715206006541848,
0.004293401259928942,
0.012732154689729214,
-0.030320294201374054,
0.01825139671564102,
0.0166169423609972,
0.003129741409793496,
-0.00006912005483172834,
0.03595797345042229,
0.0018343186238780618,
-0.034228768199682236,
-0.005048447288572788,
-0.030391357839107513,
0.008799991570413113,
-0.03967694565653801,
0.00933296512812376,
0.11910190433263779,
-0.04559887945652008,
-0.03527102991938591,
-0.010706854052841663,
0.006300935987383127,
-0.023865388706326485,
0.008782225660979748,
0.0009401067509315908,
0.03297331929206848,
-0.01684197597205639,
0.016107656061649323,
-0.010049519129097462,
0.032049499452114105,
0.01025086548179388,
0.03946375846862793,
-0.0038936706259846687,
0.028164710849523544,
0.040482331067323685,
0.004645755980163813,
0.006508203689008951,
0.006025566253811121,
0.01677091233432293,
-0.007029333617538214,
0.029893914237618446,
-0.02067938819527626,
-0.012483433820307255,
0.001564870704896748,
-0.019874004647135735,
-0.007662980817258358,
-0.007905779406428337,
0.01880805753171444,
0.006916817277669907,
0.006751003209501505,
0.0048559848219156265,
0.0029402393847703934,
-0.038208309561014175,
0.006300935987383127,
-0.018050050362944603,
0.011316812597215176,
-0.012003757059574127,
0.014485047198832035,
0.019423939287662506,
-0.02270468883216381,
0.013028251007199287,
0.02515636943280697,
0.0154562434181571,
-0.021164987236261368,
-0.006893129553645849,
0.0009637945331633091,
-0.02105839177966118,
0.019755566492676735,
-0.026482881978154182,
-0.004192728083580732,
-0.016060281544923782,
-0.030391357839107513,
-0.01234130747616291,
0.00043267119326628745,
-0.01245974563062191,
-0.015290429815649986,
-0.020324071869254112,
-0.01052919588983059,
0.021224206313490868,
0.015953686088323593,
0.006839831825345755,
0.005004032980650663
] | 2024-07-04 | 217 | 38962002 | [
"genomic engineering strategies",
"genomic engineering combinations",
"CAR T-cell therapies",
"gene delivery",
"other gene",
"CAR T-cell administration",
"gene editing",
"key cellular genes",
"CAR T-cells",
"Viral vectors",
"viral vectors",
"hematological malignancies",
"T-cell engineering",
"next-generation CAR T-cell",
"All approved CAR T-cell products",
"CAR) T-cell therapy",
"clinical trials",
"cancer treatment",
"T-cells",
"insertional mutagenesis",
"solid tumors",
"safety",
"the product cells",
"Secondary cancers",
"strategies",
"unprecedented results",
"particular regard",
"the different gene deployment",
"Chimeric antigen receptor",
"further enhancements"
] | [
"CAR T-cells",
"cell engineering",
"gene editing",
"gene modification",
"transgene delivery"
] | 0 | 10.3389/fimmu.2024.1411393
10.1136/jitc-2022-005678
10.1038/s41571-023-00754-1
10.3389/fimmu.2020.01109/full
10.1016/j.omtn.2023.04.012
10.3390/biomedicines4020009
10.3390/v13081528
10.1084/jem.20230903
10.3390/v15030698
10.1089/hum.2005.16.741
10.1038/sj.gt.3302094
10.1016/j.ymthe.2017.10.012
10.1126/scitranslmed.3003761
10.1038/mt.2014.3
10.1038/s41375-018-0106-0
10.1089/hum.2021.173
10.1038/s41591-018-0201-9
10.1182/bloodadvances.2020002229
10.1007/978-94-007-4899-6_7
10.1172/JCI35798
10.1038/s41596-018-0087-5
10.1186/s12864-020-6647-4
10.3390/cancers13236104
10.1038/sj.onc.1207006
10.1128/JVI.00011-14
10.1158/0008-5472.CAN-07-2776
10.1089/hum.2012.203
10.1038/sj.mt.6300159
10.1186/s12967-022-03729-5
10.1056/NEJM200301163480314
10.1038/nm1393
10.1038/mt.2008.5
10.1158/2326-6066.CIR-20-0922
10.1172/jci.insight.122311
10.1038/s41586-018-0178-z
10.1038/s41591-020-1081-3
10.1056/NEJMp2400209
10.1038/s41591-022-02017-5
10.1056/NEJMoa2308917
10.1001/jama.2023.8753
10.3389/fimmu.2024.1289303/full
10.3390/antib13010010
10.1158/2159-8290.CD-21-1683
10.1073/pnas.36.6.344
10.1038/nmeth.1332
10.1016/S0092-8674(00)80436-5
10.1128/jvi.47.2.287-300.1983
10.1093/nar/gks643
10.1172/JCI138473
10.1089/hum.2017.207
10.1007/PL00008641
10.1006/jmbi.2000.4047
10.1084/jem.20211530
10.1038/s41586-018-0326-5
10.1016/j.iotech.2023.100375
10.1038/leu.2016.180
10.1038/s41587-019-0291-z
10.1038/ng.343
10.1038/gt.2011.40
10.1038/ncomms11126
10.1073/pnas.1008322108
10.1002/bies.202000136
10.3389/fimmu.2022.867013/full
10.1182/blood.2021010813
10.1182/blood.2021010858
10.1182/blood.2020009655
10.1182/blood.2021012641
10.1038/mt.2016.11
10.3390/ijms22105084
10.1371/journal.pgen.1004250
10.1016/S0022-2836(02)00991-9
10.7554/eLife.10565
10.1016/j.jmb.2021.166839
10.1038/ng.3866
10.1093/nar/gkab578
10.1126/sciadv.abf1333
10.1016/j.hoc.2017.06.007
10.7717/peerj.13704
10.1038/cgt.2008.98
10.1016/j.ymthe.2005.07.688
10.1158/2326-6066.CIR-13-0170
10.1158/0008-5472.CAN-10-2880
10.1126/science.aan4672
10.1016/j.ymthe.2022.05.018
10.1007/978-1-4939-3753-0_4
10.1016/j.cell.2022.11.016
10.1016/j.tibtech.2009.02.002
10.1038/nbt1060
10.1016/j.omtm.2021.09.019
10.1146/annurev-virology-031413-085355
10.1016/j.omtm.2021.09.014
10.1038/s41408-021-00508-1
10.1016/j.omtm.2023.101139
10.1038/nnano.2017.57
10.1126/science.abm0594
10.1038/s41467-020-19486-2
10.1016/j.jconrel.2018.10.015
10.1016/j.ymthe.2021.06.004
10.1016/j.omtn.2019.05.010
10.3389/fimmu.2021.658399/full
10.1056/NEJMoa1709866
10.1056/NEJMoa2024850
10.1056/NEJMoa1709919
10.1056/NEJMoa1817226
10.1056/NEJMoa1804980
10.1056/NEJMoa1914347
10.1016/j.ymthe.2020.09.015
10.1002/jha2.356
10.3390/cancers13061229
10.1038/s41573-021-00189-2
10.1111/imcb.12254
10.1016/j.ymthe.2017.02.005
10.1158/0008-5472.CAN-14-3321
10.1126/scitranslmed.aaj2013
10.1038/mt.2015.197
10.3389/fimmu.2024.1354825/full
10.1146/annurev-genet-110410-132435
10.1038/s41587-020-0561-9
10.3389/fimmu.2022.1063303/full
10.1186/s12943-022-01559-z
10.1038/s41467-020-15053-x
10.3390/cells13020146
10.1038/s41467-019-11955-7
10.1038/ncomms15178
10.1038/nbt.2673
10.1038/nbt.2808
10.1016/j.cell.2013.08.021
10.1038/nbt.2909
10.1038/nbt.2908
10.7554/eLife.04766
10.1101/gr.171322.113
10.18632/oncotarget.15218
10.1158/1078-0432.CCR-16-1300
10.1038/s41467-019-11893-4
10.1016/j.ymthe.2021.10.004
10.3390/ijms23063207
10.1371/journal.pone.0198714
10.1093/nar/gky884/5115820
10.1093/nar/gkw908
10.1038/s41586-018-0380-z
10.1038/s41467-021-26097-y
10.1073/pnas.2004832117
10.1016/j.celrep.2020.107689
10.1038/s41467-021-25190-6
10.1038/s41587-022-01377-0
10.1016/j.ydbio.2014.06.017
10.1016/j.ydbio.2018.10.008
10.1038/nature24644
10.1038/nature17946
10.1038/s41587-022-01256-8
10.1038/s41586-021-03609-w
10.1016/j.stem.2023.10.007
10.1038/s41467-023-37604-8
10.1038/s41586-021-03534-y
10.1038/s41375-021-01282-6
10.1182/blood.2022015825
10.1038/s41467-019-13007-6
10.1038/s41586-019-1711-4
10.1038/s41587-021-01039-7
10.1038/ncomms15790
10.1038/s41467-018-04580-3
10.1038/nbt.3816
10.1093/nar/gky216
10.1038/s41587-022-01527-4
10.1073/pnas.1709035114
10.1038/s41587-020-00745-y
10.1038/s41586-022-05059-4
10.3390/ijms241914865
10.1007/s12015-023-10506-4
10.1016/j.cell.2021.03.025
10.1126/science.abj4008
10.1016/j.cmet.2022.02.009
10.1101/gr.275607.121
10.1038/nmeth.3312
10.1126/science.aau0629
10.1523/ENEURO.0495-18.2019
10.1126/science.aaf5573
10.1038/nature24049
10.1126/science.aaq0180
10.1016/j.molcel.2016.12.023
10.1016/j.molcel.2015.10.008
10.1016/j.cell.2018.02.033
10.1093/nar/gky433
10.1186/s13059-020-02193-y
10.1007/s13238-020-00700-2
10.1016/j.devcel.2020.07.013
10.1016/j.cell.2020.03.024
10.1126/sciadv.abk2485
10.1016/j.molcel.2019.09.013
10.1038/s41587-021-00822-w
10.1016/j.copbio.2022.102789
10.1016/S0092-8674(03)00759-1
10.1093/molbev/msw089
10.1038/ncb0309-228
10.1016/j.omtn.2023.102038
10.1038/mt.2008.231
10.1186/1758-907X-2-8
10.1038/mt.2012.160
10.1007/s10495-023-01925-2
10.1007/s10637-023-01344-9
10.1016/j.molimm.2021.06.007
10.1016/j.yexcr.2021.112886
10.1093/nar/gki567
10.1016/j.jviromet.2016.05.008
10.1093/nar/gkn109
10.1038/mt.2014.205
10.1261/rna.1062908
10.1016/j.omtn.2018.12.004
10.1002/advs.202308763
10.1016/j.copbio.2023.103040
10.1007/s40291-024-00705-1
10.1016/j.ccell.2023.09.014
10.1038/s41467-019-12321-3
10.1155/2019/5879616
10.18632/oncotarget.6175
10.3390/cancers14194748
10.1016/j.cellimm.2020.104262
10.1016/j.jtct.2024.03.023 | [
"Rossi",
"Breman"
] | [
"Celyad Oncology SA, Mont-Saint-Guibert, Belgium.",
"Celyad Oncology SA, Mont-Saint-Guibert, Belgium."
] | [
"38962002",
"36549782",
"37055515",
"32625204",
"37215153",
"28536376",
"34452392",
"38226974",
"36992407",
"15960605",
"14528317",
"29203150",
"22553251",
"24441399",
"29654266",
"34662233",
"30275568",
"33216892",
"18688286",
"30518911",
"32151239",
"34885212",
"14562053",
"24501411",
"18381461",
"23330935",
"17440443",
"36348415",
"12529469",
"16582916",
"18334985",
"33990375",
"30730851",
"29849141",
"33020647",
"38265704",
"36109639",
"38381673",
"37367976",
"38352878",
"38390871",
"35417527",
"15430309",
"19478801",
"9390559",
"16789244",
"22753106",
"32780725",
"29641322",
"10517322",
"10964563",
"35452075",
"29995861",
"37124148",
"27491640",
"31685959",
"19412179",
"21451576",
"27025571",
"21205896",
"32939778",
"35757746",
"34010392",
"33974080",
"34115827",
"34499707",
"26755332",
"34064900",
"24721906",
"12381300",
"26406119",
"33539889",
"28504702",
"34232995",
"33853779",
"28895845",
"35979475",
"19096447",
"16140584",
"24579088",
"20926399",
"29326244",
"35598048",
"27317172",
"36516854",
"19327858",
"15685166",
"34729382",
"26958729",
"34729380",
"34162832",
"38027056",
"28416815",
"34990237",
"33247092",
"30336167",
"34091054",
"31254925",
"33815421",
"29385370",
"33626253",
"29385376",
"31042825",
"30501490",
"32242358",
"32979309",
"35844304",
"33799768",
"33972771",
"31009109",
"28237835",
"26183927",
"28123068",
"26502778",
"38449862",
"21910633",
"32572269",
"36483551",
"35303871",
"32152313",
"38247837",
"31492858",
"28474669",
"23934178",
"24463574",
"23992846",
"24770324",
"24770325",
"25497837",
"24696461",
"28199983",
"27815355",
"31511513",
"34628052",
"35328630",
"30222773",
"30289463",
"27733506",
"30089922",
"34615869",
"34050011",
"32460021",
"34389729",
"35773341",
"24984260",
"30359560",
"29160308",
"27096365",
"35379961",
"34079130",
"37989316",
"37076455",
"34012082",
"34035409",
"35560156",
"31745080",
"31634902",
"34608327",
"28585549",
"29872041",
"28244995",
"29617873",
"36424489",
"28811374",
"33230293",
"36002573",
"37834313",
"36656467",
"33838111",
"35113687",
"35276062",
"34407984",
"25730490",
"30545847",
"30863790",
"27256883",
"28976959",
"29070703",
"28065598",
"26593719",
"29551272",
"29860393",
"33203452",
"32185621",
"32768421",
"32272060",
"35044815",
"31607545",
"33536629",
"36115160",
"14567917",
"27189568",
"19255566",
"37799328",
"19002161",
"22029761",
"23089734",
"38114800",
"36988829",
"34450537",
"34673000",
"15891114",
"27181212",
"18346971",
"25358251",
"18697922",
"30665184",
"38552157",
"38103518",
"38538969",
"37863068",
"31554797",
"31827511",
"26496034",
"36230671",
"33373818",
"38548226"
] | [] | 9.223359 | 2.820027 |
38961667 | 768 | A bibliometric and knowledge-map study on the treatment of hematological malignancies with CAR-T cells from 2012 to 2023. | Recently, CAR-T cell therapy in hematological malignancies has received extensive attention. The objective of this study is to gain a comprehensive understanding of the current research status, development trends, research hotspots, and emerging topics pertaining to CAR-T cells in the treatment of hematological malignancies. Articles pertaining to CAR-T cell therapy for hematological malignancies from the years 2012 to 2023 were obtained and assessed from the Web of Science Core Collection (WoSCC). A bibliometric approach was employed to conduct a scientific, comprehensive, and objective quantitative analysis, as well as a visual analysis, of this particular research domain. A comprehensive analysis was conducted on a corpus of 3643 articles, which were collaboratively authored by 72 countries and various research institutions. CAR-T cell research in treating hematological malignancies shows an increasing trend each year. Notably, the study identified the countries and institutions displaying the highest level of activity, the journals with the most citations and output, as well as the authors who garnered the highest frequency of citations and co-citations. Furthermore, the analysis successfully identified the research hotspots and highlighted six emerging topics within this domain. This study conducted a comprehensive exploration and analysis of the research status, development trends, research hotspots, and emerging topics about CAR-T cells in the treatment of hematological malignancies from 2012 to 2023. The findings of this study will serve as a valuable reference and guide for researchers seeking to delve deeper into this field and determine the future direction of their research. | [
-0.011147291399538517,
0.005151486024260521,
0.05385385453701019,
0.0205374862998724,
-0.0048805056139826775,
-0.008597220294177532,
-0.010200285352766514,
-0.0027668557595461607,
0.044224053621292114,
-0.002276238054037094,
0.0038022873923182487,
-0.021107971668243408,
-0.036579545587301254,
-0.0022120585199445486,
0.019293827936053276,
-0.017171621322631836,
0.03934069722890854,
0.00396202364936471,
0.040504489094018936,
0.017297128215432167,
0.03552985191345215,
-0.000009359531759400852,
0.017011884599924088,
0.002487317891791463,
-0.030783411115407944,
-0.011729186400771141,
-0.010799295268952847,
0.039135321974754333,
-0.03564395010471344,
-0.012413769960403442,
0.0033687183167785406,
-0.015927961096167564,
-0.019750216975808144,
-0.013668837957084179,
-0.0027597248554229736,
0.032472047954797745,
0.01124997902661562,
0.01613333635032177,
0.004903324879705906,
-0.02843300998210907,
0.046620093286037445,
0.018746161833405495,
0.0051628961227834225,
0.08872194588184357,
-0.09593288600444794,
-0.035872142761945724,
0.007770015858113766,
-0.092281773686409,
0.010514052584767342,
0.013029894791543484,
-0.038564834743738174,
-0.021895242854952812,
-0.06247960031032562,
-0.03434324264526367,
-0.02334427647292614,
0.04842282831668854,
-0.021701278164982796,
0.005468105897307396,
0.01980726420879364,
-0.03181028366088867,
0.007530411705374718,
0.015106462873518467,
-0.010023434646427631,
-0.037423864006996155,
-0.03623725473880768,
0.006127017084509134,
-0.05882848799228668,
-0.024097317829728127,
0.024006040766835213,
0.02038916014134884,
0.03918096050620079,
0.012276853434741497,
0.01923677884042263,
-0.001836964045651257,
0.027930982410907745,
-0.006880057975649834,
-0.04317435994744301,
0.0001282701559830457,
-0.01004625391215086,
-0.011603680439293385,
0.05093296617269516,
0.0047179171815514565,
-0.0018169970717281103,
-0.024439608678221703,
-0.03851919621229172,
-0.013086942955851555,
0.026059789583086967,
-0.004335691686719656,
-0.04086959734559059,
0.01243658922612667,
-0.048012081533670425,
0.024074498564004898,
-0.03470835089683533,
0.02220330573618412,
0.0205374862998724,
-0.014045358635485172,
-0.019773036241531372,
-0.03025856427848339,
0.021165020763874054,
0.054264605045318604,
0.010012025013566017,
0.03639699146151543,
-0.003810844849795103,
-0.02841019071638584,
0.024690622463822365,
0.05923923850059509,
-0.04395022243261337,
-0.02772560715675354,
0.03767487779259682,
-0.0249188169836998,
0.01337218564003706,
-0.036556728184223175,
-0.0037195670884102583,
0.038838669657707214,
-0.015676947310566902,
-0.05344310402870178,
-0.027246398851275444,
-0.005031684413552284,
-0.012961436063051224,
0.030235745012760162,
-0.04620934650301933,
0.04723621904850006,
0.021461673080921173,
0.008426074869930744,
0.023709386587142944,
-0.013474873267114162,
0.04146290197968483,
-0.019887132570147514,
-0.012847338803112507,
-0.062297042459249496,
0.031034424901008606,
0.012151346541941166,
0.02462216466665268,
-0.04796644300222397,
-0.04910741373896599,
-0.0026841354556381702,
-0.040960874408483505,
-0.006805894896388054,
-0.023709386587142944,
-0.03235794976353645,
0.014296372421085835,
0.006041443906724453,
-0.0007915489841252565,
0.028752481564879417,
-0.021541541442275047,
-0.04070986434817314,
0.012037249282002449,
0.034023769199848175,
0.041371624916791916,
0.0532149113714695,
-0.027383316308259964,
0.026653094217181206,
0.050157107412815094,
0.005413909908384085,
-0.007884113118052483,
-0.027930982410907745,
0.003328784368932247,
0.045616038143634796,
-0.033727116882801056,
-0.026379261165857315,
-0.02289929799735546,
-0.00017809851851779968,
-0.04568449780344963,
0.002926591783761978,
0.023595290258526802,
-0.004543919116258621,
-0.0009505718480795622,
0.005750496406108141,
-0.06384876370429993,
-0.011130176484584808,
-0.008100897073745728,
-0.08046130836009979,
-0.054127685725688934,
-0.010679492726922035,
-0.034731172025203705,
0.013178220950067043,
0.008466008119285107,
0.034594256430864334,
-0.026493357494473457,
0.002283369190990925,
0.010708017274737358,
0.03806280717253685,
0.01458161510527134,
0.0011616515694186091,
-0.03028138354420662,
-0.0034485862124711275,
-0.009635504335165024,
0.03208411857485771,
-0.040230654180049896,
-0.01909986324608326,
0.021575771272182465,
-0.01337218564003706,
0.033293548971414566,
0.013052714057266712,
0.008169355802237988,
0.009743896313011646,
0.01420509535819292,
0.031080063432455063,
-0.030372660607099533,
-0.035027824342250824,
0.02587723359465599,
0.03343046456575394,
-0.0498376339673996,
-0.01358897052705288,
-0.04404149949550629,
-0.022705333307385445,
-0.014444698579609394,
0.028798120096325874,
0.014946726150810719,
-0.008511647582054138,
0.04705366492271423,
0.008882462978363037,
-0.044908639043569565,
0.07220067828893661,
-0.03566676750779152,
-0.020160965621471405,
-0.049289967864751816,
0.04114343225955963,
0.023150311782956123,
0.03438888117671013,
-0.002289074007421732,
-0.00031751097412779927,
-0.02220330573618412,
0.02590005286037922,
0.005473810713738203,
0.0014476075302809477,
0.03039547987282276,
-0.021872423589229584,
0.017319947481155396,
-0.016509857028722763,
0.028798120096325874,
0.01571117714047432,
0.03972862660884857,
-0.016156155616044998,
-0.03792589157819748,
-0.043904583901166916,
0.010953325778245926,
0.017034703865647316,
0.05216521769762039,
-0.05234777182340622,
0.01981867477297783,
0.004954668693244457,
0.03228949382901192,
0.00863715447485447,
0.001878324314020574,
-0.019864313304424286,
0.010371430777013302,
-0.08630308508872986,
0.01882603019475937,
0.0022790904622524977,
0.018483737483620644,
0.020754272118210793,
-0.009236164391040802,
-0.019567660987377167,
0.04570731893181801,
-0.0070740231312811375,
0.033179450780153275,
-0.03778897598385811,
0.030372660607099533,
-0.011911742389202118,
-0.004059005994349718,
-0.020971056073904037,
-0.04098369553685188,
-0.05316927284002304,
-0.07032947987318039,
0.014296372421085835,
-0.022579826414585114,
0.026082608848810196,
0.030030369758605957,
-0.02788534387946129,
0.017228668555617332,
0.013166811317205429,
0.06695220619440079,
-0.03238077089190483,
-0.0586002953350544,
0.011866103857755661,
0.009139182046055794,
0.010639559477567673,
0.004469755571335554,
-0.00812371727079153,
0.041645459830760956,
0.016064878553152084,
0.012322491966187954,
-0.012573505751788616,
-0.004849128890782595,
-0.00434710131958127,
-0.008968035690486431,
0.047875162214040756,
0.00898515060544014,
-0.02434833161532879,
0.04515965282917023,
-0.017468273639678955,
-0.0008535892702639103,
-0.02093682624399662,
0.03228949382901192,
-0.01159797515720129,
0.01024592388421297,
-0.0028025112114846706,
-0.038975585252046585,
-0.00804955419152975,
-0.024508068338036537,
-0.005719119682908058,
-0.009504292160272598,
-0.02774842642247677,
0.03272306174039841,
0.026904108002781868,
-0.008448894135653973,
-0.01420509535819292,
0.020001230761408806,
0.01994418166577816,
0.012516457587480545,
-0.009926452301442623,
0.01061103492975235,
0.013942671939730644,
-0.021986519917845726,
0.023013394325971603,
0.026972565799951553,
-0.024234233424067497,
-0.004136021714657545,
-0.058919768780469894,
-0.013703067786991596,
-0.004178808070719242,
0.0025429402012377977,
0.06435079127550125,
0.005160043481737375,
-0.052895437926054,
0.016304481774568558,
0.007901227101683617,
0.0491986908018589,
-0.03559831157326698,
-0.013098352588713169,
-0.009310327470302582,
0.05540557578206062,
-0.019065633416175842,
0.0012358147650957108,
-0.029916271567344666,
-0.022134846076369286,
-0.03270024433732033,
-0.006777370814234018,
-0.01307553332298994,
0.0011231438256800175,
0.00403618672862649,
-0.02292211726307869,
0.03961452841758728,
-0.02943706512451172,
-0.007467658258974552,
-0.030669312924146652,
0.021461673080921173,
-0.009589864872395992,
-0.002018093364313245,
0.012539276853203773,
0.023435553535819054,
0.04397303983569145,
0.030646493658423424,
-0.01627025380730629,
0.025945691391825676,
-0.010565396398305893,
0.011443943716585636,
0.0345257967710495,
-0.011660728603601456,
0.00025208338047377765,
-0.028752481564879417,
-0.0410749725997448,
0.05358001962304115,
0.06051712855696678,
0.047738246619701385,
-0.02982499450445175,
0.023435553535819054,
-0.021678458899259567,
-0.05713985115289688,
-0.02701820433139801,
-0.03438888117671013,
-0.01329231821000576,
-0.024576526135206223,
-0.010097597725689411,
0.03605470061302185,
0.004110349807888269,
0.020868368446826935,
0.013360776007175446,
0.035849325358867645,
0.026812829077243805,
-0.00759886996820569,
-0.013805755414068699,
-0.027520231902599335,
-0.0036282893270254135,
0.032312311232089996,
0.0006403702427633107,
-0.004506837576627731,
-0.06220576539635658,
0.04481735825538635,
-0.041371624916791916,
0.024530887603759766,
0.014170865528285503,
0.0023703682236373425,
-0.0032917028293013573,
0.04283206909894943,
-0.04625498503446579,
0.07722094655036926,
0.05020274594426155,
-0.0045610335655510426,
-0.03482244908809662,
-0.030235745012760162,
-0.01784479431807995,
-0.03297407552599907,
0.031057244166731834,
-0.008734136819839478,
0.01300707459449768,
0.04851410910487175,
0.04468044266104698,
-0.03434324264526367,
-0.006828714162111282,
0.03181028366088867,
0.02218048647046089,
0.0160991083830595,
-0.001553147449158132,
-0.01329231821000576,
-0.036853380501270294,
0.07566922903060913,
-0.040664222091436386,
0.03057803586125374,
0.03676209971308708,
-0.01725148968398571,
0.007416314445436001,
-0.008300567977130413,
0.0021892390213906765,
-0.013121171854436398,
0.058782849460840225,
0.005927346646785736,
-0.0015289017464965582,
-0.04045885056257248,
-0.04600397124886513,
0.048012081533670425,
-0.0099777951836586,
0.01224262360483408,
0.00003044076220248826,
-0.00392779428511858,
0.003402947448194027,
0.04513683170080185,
-0.020012639462947845,
0.022248944267630577,
0.0003615453315433115,
0.012664783746004105,
-0.0027853965293616056,
0.0043556587770581245,
0.08278889209032059,
-0.0019496349850669503,
0.018506556749343872,
0.024667803198099136,
-0.009949271567165852,
-0.022260352969169617,
-0.013474873267114162,
-0.019168321043252945,
0.016783690080046654,
-0.034457337111234665,
-0.04910741373896599,
-0.009509997442364693,
0.012870158068835735,
-0.07521284371614456,
-0.003499930026009679,
0.019750216975808144,
0.016760870814323425,
-0.03370429947972298,
-0.0016586872516199946,
-0.0549035482108593,
-0.0031119997147470713,
0.00842036958783865,
0.016338711604475975,
-0.04531938582658768,
-0.0022120585199445486,
-0.017742106691002846,
0.07452825456857681,
-0.013531921431422234,
-0.050567857921123505,
-0.014056768268346786,
0.030669312924146652,
0.0579613521695137,
0.0031690483447164297,
0.011443943716585636,
0.013839984312653542,
0.005174305755645037,
0.01224262360483408,
-0.024850359186530113,
-0.020058277994394302,
0.006919992156326771,
0.03482244908809662,
-0.003137671621516347,
-0.03197002038359642,
0.011729186400771141,
0.022283172234892845,
0.024120137095451355,
-0.023937581107020378,
-0.004044743720442057,
0.041097793728113174,
-0.009413015097379684,
-0.02957398071885109,
-0.03194720298051834,
-0.05773315578699112,
0.009281802922487259,
-0.0325176864862442,
-0.003830811707302928,
0.012573505751788616,
0.01897435635328293,
-0.012276853434741497,
0.016589725390076637,
0.0808720588684082,
0.0744369775056839,
-0.005336894188076258,
0.04630062356591225,
-0.012835929170250893,
0.026128247380256653,
-0.01655549556016922,
-0.018164265900850296,
0.046483177691698074,
-0.006600520107895136,
-0.005148633848875761,
-0.032335132360458374,
-0.039386335760354996,
-0.012892977334558964,
-0.01243658922612667,
-0.018552197143435478,
-0.01937369629740715,
-0.013668837957084179,
-0.017023295164108276,
-0.004059005994349718,
-0.007267988286912441,
-0.03956888988614082,
-0.01882603019475937,
-0.03377275541424751,
-0.005473810713738203,
-0.03384121507406235,
0.011660728603601456,
-0.02335568703711033,
-0.007787130307406187,
-0.0011659301817417145,
-0.022545596584677696,
-0.03717285022139549,
-0.036442629992961884,
0.014364831149578094,
-0.0495181642472744,
-0.02660745568573475,
-0.006982745602726936,
-0.03028138354420662,
0.011866103857755661,
-0.01940792426466942,
-0.03123980015516281,
0.008026733994483948,
-0.010434184223413467,
-0.021701278164982796,
0.0011281355982646346,
-0.01813003607094288,
0.02402886003255844,
-0.02916323021054268,
0.012607734650373459,
0.020868368446826935,
0.016646774485707283,
-0.019464973360300064,
0.012699012644588947,
-0.05773315578699112,
-0.001541737699881196,
-0.01964752934873104,
0.011483877897262573,
-0.012596325017511845,
0.004854833707213402,
0.0016429988900199533,
-0.05011146888136864,
0.023869123309850693,
-0.014148046262562275,
-0.03920378163456917,
-0.03370429947972298,
0.01167213823646307,
0.0076045747846364975,
-0.026653094217181206,
0.03130825608968735,
-0.040938057005405426,
0.026493357494473457,
-0.016738051548600197,
-0.028912218287587166,
0.015779634937644005,
-0.013452054001390934,
0.0247590821236372,
-0.025991329923272133,
0.0010183170670643449,
-0.009030789136886597,
0.04198775067925453,
-0.014376240782439709,
0.0319928415119648,
-0.012082887813448906,
0.009567045606672764,
0.0017399814678356051,
-0.016874969005584717,
0.06622198224067688,
0.012710422277450562,
0.05011146888136864,
0.007963980548083782,
-0.031080063432455063,
0.0020922564435750246,
0.017582369968295097,
-0.010981850326061249,
0.009766715578734875,
0.015391705557703972,
-0.012573505751788616,
-0.01698906533420086,
-0.03169618919491768,
-0.033886853605508804,
-0.00544243399053812,
0.05020274594426155,
0.02971089817583561,
-0.010919096879661083,
0.008825414814054966,
0.02674437128007412,
0.007621689699590206,
0.008831119164824486,
-0.021393215283751488,
-0.02067440375685692,
0.05485790967941284,
0.012048658914864063,
-0.03785743564367294,
-0.02660745568573475,
-0.026082608848810196,
-0.019841494038701057,
0.012744651176035404,
-0.01477558072656393,
-0.027976620942354202,
-0.01724007911980152,
0.014513157308101654,
-0.024576526135206223,
-0.0077072624117136,
0.0012415195815265179,
0.0003918524016626179,
-0.013908442109823227,
-0.00763309933245182,
-0.037834614515304565,
-0.014262143522500992,
-0.011078832671046257,
-0.02674437128007412,
-0.006298162508755922,
0.03333918750286102,
-0.022317402064800262,
0.006977040786296129,
0.009025084786117077,
0.003354456275701523,
-0.006514947395771742,
-0.028227634727954865,
-0.013509102165699005,
0.019909951835870743,
-0.007912637665867805,
-0.022465728223323822,
-0.0006097066216170788,
0.009960681200027466,
-0.004769260995090008,
-0.0016544086392968893,
-0.033019714057445526,
0.007444838993251324,
-0.016635363921523094,
0.0029722307808697224,
-0.017639419063925743,
0.026219524443149567,
-0.002709807362407446,
0.03507346287369728,
0.08100897818803787,
-0.052119579166173935,
0.02307044342160225,
0.0018469475908204913,
-0.013976900838315487,
-0.011968790553510189,
0.007056908681988716,
0.021142201498150826,
0.006919992156326771,
0.0025144158862531185,
0.0498376339673996,
0.02884375862777233,
0.014672893099486828,
0.005990100093185902,
-0.015756815671920776,
-0.0071595958434045315,
0.002859559841454029,
0.025101372972130775,
0.0012251181760802865,
-0.027337675914168358,
0.048331551253795624,
-0.017308536916971207,
0.020309291779994965,
-0.03776615485548973,
-0.024941636249423027,
0.009196230210363865,
0.004221594426780939,
0.02548930235207081,
0.0159964207559824,
0.032905615866184235,
-0.022728152573108673,
0.025649039074778557,
-0.022579826414585114,
-0.028113536536693573,
0.002210632199421525,
0.01526619866490364,
0.010976145975291729,
-0.02191806212067604,
-0.02674437128007412,
-0.03393249213695526,
-0.040413208305835724,
0.05330618843436241,
0.0015089347725734115,
0.05065913498401642,
-0.027086662128567696,
0.03377275541424751,
-0.007016974501311779,
0.022739561274647713,
-0.042375680059194565,
0.000945580133702606,
0.017924662679433823,
0.009743896313011646,
0.007479067891836166,
-0.007872703485190868,
-0.008209289982914925,
-0.028615564107894897,
0.006127017084509134,
0.015939371660351753,
0.04214748740196228,
0.0028524287045001984,
0.03448015823960304,
-0.003294555237516761,
0.02943706512451172,
-0.014661483466625214,
-0.017730696126818657,
0.026561815291643143,
0.02872966229915619,
-0.023081853985786438,
0.030760591849684715,
-0.006994155235588551,
-0.026082608848810196,
-0.009156296029686928,
0.005319779738783836,
-0.007131071761250496,
-0.031331077218055725,
-0.009179115295410156,
0.015300427563488483,
-0.047190580517053604,
-0.025078553706407547,
-0.010257333517074585,
0.005199977662414312,
0.02249995805323124,
-0.006041443906724453,
-0.02163281850516796,
0.02261405438184738,
0.004703654907643795,
0.00672032218426466,
0.044224053621292114,
0.006840124260634184,
-0.007245169021189213,
-0.037697698920965195,
0.019601890817284584,
0.007113957311958075,
-0.0037537962198257446,
-0.016190385445952415,
0.01881461963057518,
-0.01883743889629841,
-0.025101372972130775,
-0.00835191085934639,
-0.010656673461198807,
0.0028082160279154778,
-0.02106233313679695,
0.0015987863298505545,
0.02078850008547306,
0.004743589088320732,
0.00011106644524261355,
-0.002534382976591587,
0.011386895552277565,
0.027839703485369682,
-0.000409680069424212,
0.01753673143684864,
-0.010862048715353012,
-0.02505573444068432,
0.03719567134976387,
-0.016646774485707283,
-0.01201443001627922,
0.029254509136080742,
0.003203277476131916,
0.03781179338693619,
0.014570205472409725,
-0.0010275874519720674,
-0.007370675913989544,
-0.025010094046592712,
-0.004318577237427235,
-0.0032289493829011917,
0.00785558857023716,
-0.008814004249870777,
0.016167566180229187,
0.016042059287428856,
-0.007558936253190041,
-0.003077770583331585,
-0.037104394286870956,
-0.016943426802754402,
-0.010377136059105396,
-0.001896865083836019,
-0.010399955324828625,
0.043060265481472015,
0.04340255632996559,
-0.0751672014594078,
-0.017342766746878624,
0.027543051168322563,
0.00355127383954823,
0.005331189371645451,
-0.0014525993028655648,
-0.023013394325971603,
-0.00042073323857039213,
0.009447243995964527,
0.008523057214915752,
0.028798120096325874,
-0.020035458728671074,
-0.00792404729872942,
0.014113817363977432,
-0.0065434714779257774,
-0.01315540075302124,
-0.014421879313886166,
-0.05741368606686592,
-0.03518756106495857,
0.03208411857485771,
-0.003847926389425993,
-0.01243658922612667,
-0.027109483256936073,
0.06558304280042648,
-0.01951061189174652,
0.0059330519288778305,
-0.0076388041488826275,
-0.02745177410542965,
-0.03879303112626076,
0.01726289838552475,
-0.0025443665217608213,
-0.005870298482477665,
-0.038838669657707214,
0.021861013025045395,
0.007581755518913269,
-0.028889397159218788,
0.003936351742595434,
-0.010725132189691067,
-0.00313196680508554,
0.0182669535279274,
-0.0036881903652101755,
0.027337675914168358,
0.03623725473880768,
0.014090998098254204,
0.011774825863540173,
0.013703067786991596,
-0.026630274951457977,
-0.012710422277450562,
0.00558790797367692,
0.009567045606672764,
-0.005687742959707975,
-0.011991610750555992,
-0.004059005994349718,
-0.026653094217181206,
0.005841773934662342,
-0.010103302076458931,
-0.03139953687787056,
0.013303727842867374,
0.023013394325971603,
0.00045496236998587847,
-0.020765680819749832,
0.05052221566438675,
0.038701754063367844,
0.002590005286037922,
-0.011603680439293385,
-0.023093262687325478,
-0.07607997953891754,
0.028752481564879417,
-0.027520231902599335,
-0.0015146395890042186,
0.0007615984650328755,
-0.0010076204780489206,
-0.003594060195609927,
0.01642998866736889,
0.007644508965313435,
0.009287508204579353,
-0.013976900838315487,
-0.007513297256082296,
-0.0017499650130048394,
-0.006925696972757578,
-0.03139953687787056,
-0.0562727153301239,
-0.04960944131016731,
0.0021236331667751074,
0.001517492113634944,
-0.030349841341376305,
0.01095903106033802,
-0.004663720726966858,
0.021313346922397614,
-0.010514052584767342,
-0.010491232387721539,
-0.003668223274871707,
0.011244273744523525,
-0.001150241820141673,
-0.023663748055696487,
-0.026402080431580544,
-0.004572443198412657,
0.016521267592906952,
0.020115327090024948,
-0.02505573444068432,
0.014615844935178757,
-0.03626007214188576,
0.02831891179084778,
-0.024439608678221703,
-0.008979445323348045,
-0.015152101404964924,
0.03044111840426922,
0.0005583629244938493,
-0.0014354847371578217,
-0.035301659256219864,
0.04424687474966049,
-0.004774965811520815,
0.027337675914168358,
-0.012938616797327995,
0.020594535395503044,
0.004113201983273029,
0.03717285022139549,
-0.01280170027166605,
-0.003907827194780111,
-0.009618389420211315,
0.05047657713294029,
0.0272920373827219,
-0.009738191962242126,
-0.018723342567682266,
-0.025785954669117928,
-0.009532816708087921,
-0.0005309082916937768,
0.015368886291980743,
0.015813864767551422,
0.01528901793062687,
0.02123347856104374,
0.005876003298908472,
0.007735786493867636,
-0.006971335969865322,
0.0017685057828202844,
0.023013394325971603,
0.03861047327518463,
0.03986554220318794,
-0.006212589796632528,
0.014878268353641033,
0.004977487958967686,
-0.004318577237427235,
-0.0019767330959439278,
0.01344064436852932,
0.06946234405040741,
0.0008236388093791902,
-0.045821413397789,
0.019727397710084915,
0.02318453975021839,
0.025238288566470146,
-0.01766223832964897,
0.021746916696429253,
0.04636907950043678,
0.0667240098118782,
0.006851533893495798,
-0.010673788376152515,
-0.011797645129263401,
-0.01358897052705288,
-0.019328057765960693,
0.03660236671566963,
-0.028547106310725212,
0.04819463565945625,
-0.012060068547725677,
-0.0020680108573287725,
0.030669312924146652,
-0.006178360432386398,
-0.0030692133586853743,
-0.02658463642001152,
0.00381654966622591,
0.018084397539496422,
0.00431001977995038,
-0.03144517540931702,
0.019693167880177498,
0.009880812838673592,
-0.01654408685863018,
0.04045885056257248,
-0.0063095721416175365,
0.022808019071817398,
0.02459934540092945,
0.0218039657920599,
-0.05869157239794731,
-0.01909986324608326,
-0.017342766746878624,
0.028615564107894897,
0.028638383373618126,
-0.012254034169018269,
-0.017285717651247978,
-0.005565088242292404,
-0.013691658154129982,
-0.0033943902235478163,
-0.019601890817284584,
-0.03993400186300278,
0.0010147514985874295,
0.05476663261651993,
0.01754814200103283,
-0.04938124492764473,
-0.0010789311490952969,
0.02150731161236763,
-0.046346262097358704,
0.008642858825623989,
-0.06530920416116714,
0.021107971668243408,
0.050430938601493835,
0.017593780532479286,
-0.007821359671652317,
0.009909337386488914,
-0.00800391472876072,
-0.03454861789941788,
0.005063061136752367,
0.04340255632996559,
-0.001193028292618692,
0.06220576539635658,
-0.0461408868432045,
0.03975144773721695,
0.0006706772837787867,
0.0005501621635630727,
0.004928996786475182,
0.02870684303343296,
-0.00974960159510374,
-0.017422635108232498,
-0.051024243235588074,
-0.016623955219984055,
-0.006349506322294474,
-0.03632853180170059,
0.03438888117671013,
0.017924662679433823,
0.03153645247220993,
0.013497692532837391,
0.0030093123205006123,
-0.005816102027893066,
-0.019179729744791985,
0.008928101509809494,
0.014273553155362606,
0.010599625296890736,
0.017502503469586372,
0.008380435407161713,
-0.012048658914864063,
-0.021701278164982796,
0.006840124260634184,
-0.006857238709926605,
0.05394513159990311,
0.03872457146644592,
0.020480437204241753,
-0.02742895483970642,
-0.013315137475728989,
0.020845549181103706,
0.04201057180762291,
-0.035849325358867645,
0.0011759137269109488,
-0.01110165286809206,
-0.01655549556016922,
0.017593780532479286,
0.02856992557644844,
0.037423864006996155,
0.04682546854019165,
0.014467518776655197,
0.013143991120159626,
0.004295757506042719,
0.021758325397968292,
0.014410469681024551,
0.005045946221798658,
-0.010747951455414295,
-0.03322508931159973,
-0.03493654727935791,
0.029345786198973656,
-0.0008364747045561671,
0.005199977662414312,
-0.03137671574950218,
0.004997455049306154,
0.014638664200901985,
0.002507284749299288,
0.027930982410907745,
-0.019476383924484253,
0.0077586062252521515,
-0.008734136819839478,
-0.009738191962242126,
0.005602169781923294,
-0.01811862736940384,
-0.0043157245963811874,
0.012071478180587292,
-0.01019458007067442,
0.017593780532479286,
-0.004735031630843878,
0.013497692532837391,
0.027406135573983192,
0.027930982410907745,
-0.022237533703446388,
-0.02982499450445175,
-0.003017869545146823,
-0.03940915688872337,
-0.021450264379382133,
0.016795100644230843,
-0.011923152022063732,
-0.011124472133815289,
-0.022009339183568954,
-0.019841494038701057,
-0.002801084890961647,
-0.013109762221574783,
-0.003685337956994772,
0.007353560999035835,
0.012687603011727333,
0.02957398071885109,
0.00438418285921216,
-0.003157638479024172,
0.01117581594735384,
-0.004569591023027897,
-0.0365339070558548,
-0.05207393690943718,
0.008682793006300926,
-0.010919096879661083,
-0.0441327765583992,
0.01522055920213461,
-0.0220663882791996,
-0.01144964899867773,
0.004652311094105244,
0.005294107832014561,
-0.001818423275835812,
-0.016372941434383392,
0.02715512178838253,
0.011238569393754005,
0.005465253256261349,
-0.012641964480280876,
0.010051959194242954,
-0.007439134176820517,
-0.018883077427744865,
-0.0052484688349068165,
0.004757850896567106,
0.013143991120159626,
0.0026712995022535324,
-0.026995385065674782,
0.0040761204436421394,
-0.013029894791543484,
-0.006087082903832197,
-0.011763416230678558,
0.01031438261270523,
-0.006914287339895964,
0.03235794976353645,
0.009270393289625645,
0.010924802161753178,
0.0040304819121956825,
-0.003636846551671624,
0.00854587648063898,
-0.01783338375389576,
0.008819709531962872,
0.027816884219646454,
-0.027520231902599335,
0.00012693308235611767,
-0.01471853256225586,
0.008015324361622334,
-0.018187085166573524,
0.05672910064458847,
-0.006178360432386398,
-0.050020188093185425,
0.030600855126976967,
0.011335551738739014,
-0.012813109904527664,
-0.03242640942335129,
0.017057523131370544,
0.004980340600013733,
-0.00002308684452145826,
0.002746888902038336,
0.018335411325097084,
0.023389915004372597,
-0.01624743454158306,
0.017616599798202515,
0.010873458348214626,
-0.007787130307406187,
-0.00015617047029081732,
-0.006640453822910786,
0.012824519537389278,
0.01866629347205162,
-0.008728431537747383,
-0.02815917693078518,
0.00003734898928087205,
0.01470712199807167,
-0.006931401789188385,
0.045889873057603836,
0.031216979026794434,
0.008808299899101257,
0.02927732840180397,
0.008083783090114594,
-0.022374451160430908,
-0.0046380492858588696,
-0.03128543868660927,
-0.01738840527832508,
-0.01937369629740715,
-0.038861487060785294,
-0.0036625184584409,
0.0008778349147178233,
-0.008682793006300926,
0.04004810005426407,
-0.015939371660351753,
0.021575771272182465,
-0.013269498012959957,
-0.03888430818915367,
-0.005710562225431204,
0.0017428339924663305,
0.02487317845225334,
-0.014570205472409725,
0.00008967323083197698,
-0.02079991064965725,
-0.00940730981528759,
0.00389071274548769,
0.003283145371824503,
-0.010331496596336365,
0.03242640942335129,
0.0182669535279274,
0.012071478180587292,
0.054401520639657974,
0.019213959574699402,
-0.00358835537917912,
0.005045946221798658,
-0.06649582087993622,
0.015003775246441364,
-0.019852904602885246,
-0.00898515060544014,
0.01614474691450596,
-0.03249486908316612,
-0.010924802161753178,
-0.026812829077243805,
-0.0020551749039441347,
0.010354315862059593,
-0.0022434352431446314,
0.023983221501111984,
0.0016101959627121687,
0.006771665532141924,
0.021564360707998276,
0.00812942162156105,
-0.019613299518823624,
-0.013691658154129982,
-0.012687603011727333,
0.051982659846544266,
0.002969378372654319,
-0.012402360327541828,
-0.03788025304675102,
-0.03249486908316612,
0.020343521609902382,
0.003571240697056055,
0.014262143522500992,
0.0012714701006188989,
0.007182415574789047,
0.013703067786991596,
0.034000951796770096,
0.011238569393754005,
-0.007125366944819689,
-0.0005309082916937768,
-0.018289772793650627,
-0.016909196972846985,
0.02010391838848591,
0.025808775797486305,
0.018860258162021637,
0.028067898005247116,
-0.03053239732980728,
0.002025224268436432,
0.013531921431422234,
-0.039979640394449234,
-0.03281433880329132,
-0.03945479542016983,
-0.003608322236686945,
-0.007410609629005194,
0.010331496596336365,
-0.008705612272024155,
0.017354175448417664,
-0.007364971097558737,
0.01739981584250927,
0.015129282139241695,
-0.022568415850400925,
-0.02827327325940132,
-0.024439608678221703,
0.0132238594815135,
0.022442908957600594,
0.022385859861969948,
0.03254050761461258,
0.013782935217022896,
0.005388238001614809,
-0.024987274780869484,
0.0446576252579689,
0.00021963700419291854,
0.006064263638108969,
-0.009915041737258434,
-0.01628166250884533,
0.009589864872395992,
-0.007804244756698608,
-0.007752901408821344,
0.0249188169836998,
0.04073268175125122,
-0.015813864767551422,
-0.009641208685934544,
0.022020749747753143,
-0.018997175619006157,
-0.011392599903047085,
0.003936351742595434,
-0.017993120476603508,
0.0023047623690217733,
0.001295715686865151,
-0.012322491966187954,
0.006149836350232363,
-0.023504013195633888,
0.004763555712997913,
0.0032660309225320816,
-0.0227509718388319,
-0.01265337411314249,
0.034160684794187546,
-0.0015018037520349026,
-0.00763309933245182,
-0.008899577893316746,
-0.05937615782022476,
-0.045045554637908936,
-0.01883743889629841,
0.01992136240005493,
-0.007182415574789047,
-0.011118766851723194,
-0.036990296095609665,
-0.005927346646785736,
0.04696238785982132,
-0.04979199543595314,
0.009726782329380512,
0.041942112147808075,
0.04016219452023506,
0.016886377707123756,
0.0036824855487793684,
-0.008654268458485603,
0.014969545416533947,
-0.013018484227359295,
-0.018757570534944534,
-0.0008756956085562706,
0.0020794204901903868,
0.032061297446489334,
-0.01839246042072773,
0.03945479542016983,
0.010565396398305893,
0.01712598279118538,
0.009606979787349701,
-0.01582527533173561,
-0.010422774590551853,
0.03594060242176056,
-0.0257631354033947,
-0.0028110684361308813,
0.001590228988789022,
-0.0010996112832799554,
-0.01159797515720129,
0.023800665512681007,
0.03169618919491768,
-0.014752761460840702,
0.005011717323213816,
0.00805525854229927,
0.04709930345416069,
-0.03491372615098953,
-0.012972845695912838,
0.014068178832530975,
0.031627729535102844,
-0.009892222471535206,
-0.007307922467589378,
0.006840124260634184,
0.007410609629005194,
-0.02448524720966816,
0.00891669187694788,
0.00714248139411211,
-0.016361530870199203,
0.01967034861445427,
-0.009104952216148376,
-0.0071082524955272675,
0.0009298917721025646,
-0.006554881110787392,
0.002083699218928814,
-0.00047564247506670654,
-0.005893117748200893,
-0.0030093123205006123,
0.007986800745129585,
0.004241561517119408,
0.005536564160138369,
-0.014170865528285503,
-0.013543331064283848,
-0.018198495730757713,
0.013041304424405098,
0.02532956749200821,
-0.008078077808022499,
-0.008483123034238815,
-0.017491092905402184,
-0.033042535185813904,
0.008534466847777367,
-0.00906501803547144,
-0.01407958846539259,
-0.0018640621565282345,
0.006977040786296129,
0.012174165807664394,
-0.03564395010471344,
-0.013954081572592258,
0.006526357028633356,
0.014456109143793583,
-0.017342766746878624,
0.02319595031440258,
0.0021350427996367216,
-0.008112307637929916,
0.02532956749200821,
0.039386335760354996,
0.011991610750555992,
0.03801716864109039,
-0.018905896693468094,
0.01166643388569355,
0.007353560999035835,
0.020183784887194633,
-0.00856869574636221,
-0.03025856427848339,
-0.013817165046930313,
0.020469028502702713,
-0.008163650520145893,
-0.005704857409000397,
-0.028045078739523888,
0.007131071761250496,
-0.015813864767551422,
0.026287982240319252,
-0.011244273744523525,
-0.008414664305746555,
0.012676193378865719,
0.01344064436852932,
-0.050020188093185425,
-0.0008086635498329997,
-0.023504013195633888,
0.022557007148861885,
0.02715512178838253,
0.027634330093860626,
-0.010097597725689411,
-0.013543331064283848,
-0.00626393361017108,
0.03523319959640503,
-0.012390950694680214,
-0.006246818695217371,
0.034297604113817215,
0.00668609282001853,
-0.011991610750555992,
0.04347101226449013,
0.006446488667279482,
-0.03194720298051834,
-0.003959171008318663,
-0.02745177410542965,
0.001988142728805542,
0.02081131935119629,
-0.0005191420204937458,
0.0175253227353096,
0.004957520868629217,
0.04246695712208748,
0.0036653708666563034,
0.015106462873518467,
-0.021107971668243408,
0.01783338375389576,
-0.02024083398282528,
-0.023230180144309998,
-0.01724007911980152,
-0.00027205038350075483,
-0.035005006939172745,
-0.0056164320558309555,
0.012562096118927002,
-0.034594256430864334,
0.03788025304675102,
-0.024781901389360428,
0.024416789412498474,
-0.0025743169244378805,
-0.016190385445952415,
-0.01600782945752144,
-0.012128527276217937,
-0.013782935217022896,
0.003003607504069805,
0.03908968344330788,
0.022956347092986107,
0.012276853434741497,
0.03509628400206566,
0.03324791043996811,
-0.014866858720779419,
-0.012288263067603111,
-0.006817304529249668,
-0.017034703865647316,
-0.0099777951836586,
-0.015106462873518467,
0.10478682070970535,
-0.03662518411874771,
-0.035986240953207016,
0.013839984312653542,
-0.004780670627951622,
-0.018426690250635147,
0.013634609058499336,
0.028684023767709732,
0.0051714531145989895,
0.002637070370838046,
0.0027982324827462435,
0.010593920014798641,
0.06298162788152695,
0.0345257967710495,
0.020845549181103706,
-0.002307614777237177,
0.005565088242292404,
0.030509578064084053,
0.006469308398663998,
-0.020252244547009468,
0.002331860363483429,
0.005533711519092321,
0.012744651176035404,
0.010924802161753178,
-0.012641964480280876,
-0.014901087619364262,
-0.02758868969976902,
-0.02010391838848591,
-0.007513297256082296,
0.00970396213233471,
0.01613333635032177,
0.00940730981528759,
0.011518106795847416,
-0.008848234079778194,
0.006338096689432859,
-0.0421246662735939,
-0.005915937013924122,
0.02489599771797657,
0.019339466467499733,
0.009310327470302582,
-0.006731731817126274,
-0.023526832461357117,
-0.010405659675598145,
-0.0375836007297039,
0.03279152140021324,
0.02092541754245758,
-0.011683547869324684,
-0.0032859977800399065,
0.010531166568398476,
-0.025991329923272133,
-0.007701557595282793,
0.003420062130317092,
0.009584160521626472,
-0.006052853539586067,
-0.04643753916025162,
-0.006891467608511448,
0.009350261650979519,
-0.018780389800667763,
-0.0054880729876458645,
-0.0047179171815514565,
-0.018894487991929054,
0.015540031716227531,
0.020411979407072067,
0.021895242854952812,
0.0026812830474227667
] | 2024-07-04 | 85 | 38961667 | [
"research hotspots",
"various research institutions",
"hematological malignancies",
"emerging topics",
"analysis",
"CAR-T cell research",
"development trends",
"Science Core Collection",
"CAR-T cell therapy",
"citations",
"CAR-T cells",
"the current research status",
"the research hotspots",
"this particular research domain",
"the research status",
"institutions",
"A comprehensive analysis",
"Articles",
"guide",
"researchers",
"output",
"activity",
"extensive attention",
"their research",
"a visual analysis",
"six emerging topics",
"a comprehensive understanding",
"co",
"a comprehensive exploration",
"the highest frequency"
] | [
"CAR-T cells",
"bibliometric",
"development trends",
"emerging themes",
"hematological malignancies",
"research hotspots"
] | 0 | 10.1080/21645515.2024.2371664
10.1016/j.jcyt.2022.05.001
10.1016/s1470-2045(23)00436-9
10.1200/jco.22.01214
10.1136/jitc-2023-006959
10.1038/s41375-021-01232-2
10.1002/cam4.5818
10.1186/s40164-023-00450-x
10.1182/blood.2020009192
10.3389/fonc.2022.832765
10.1016/j.canlet.2022.215945
10.1182/blood.2021012634
10.1016/j.ymthe.2022.07.021
10.3389/fimmu.2023.1140541
10.1517/14712598.2012.674507
10.1073/pnas.0307513100
10.1007/s11192-009-0146-3
10.1056/NEJMoa1709866
10.1056/NEJMoa1707447
10.1056/NEJMoa1804980
10.1056/NEJMoa1709919
10.1016/s1470-2045(18)30864-7
10.1056/NEJMoa1407222
10.1016/s0140-6736(14)61403-3
10.1172/jci85309
10.1016/s0140-6736(20)31366-0
10.1126/scitranslmed.3008226
10.1200/jco.19.02104
10.1200/jco.19.02103
10.1038/s41591-020-1081-3
10.1182/bloodadvances.2020001900
10.1200/jco.19.03279
10.1038/s41591-019-0737-3
10.1016/j.cell.2020.08.022
10.3324/haematol.2019.238634
10.1200/jco.20.02477
10.1126/science.aba7365
10.1182/blood.2020005278
10.1158/2643-3230.Bcd-20-0020
10.1182/bloodadvances.2019000525
10.1186/s13045-020-00856-8
10.1016/s1470-2045(19)30788-0
10.1182/blood.2019002936
10.1038/s41467-019-13880-1
10.1038/s41587-020-0462-y
10.1038/s41375-019-0580-z
10.3389/fimmu.2020.01941
10.1172/jci.insight.133977
10.1056/NEJMoa1910607
10.1182/blood.2019000017
10.1097/cm9.0000000000002549
10.3389/fimmu.2022.840956
10.1038/s41417-023-00593-3
10.1097/cm9.0000000000000568
10.3389/fimmu.2023.1152457
10.1186/s13045-020-01001-1
10.1016/j.phrs.2023.106742
10.1016/j.yexcr.2021.112971
10.1016/j.phrs.2021.106036
10.1186/s12967-022-03442-3
10.3389/fimmu.2021.627764
10.3389/fphar.2022.950923
10.3389/fimmu.2021.663201
10.3390/ijms241512317
10.1186/s12943-022-01559-z
10.1016/j.lfs.2023.121409
10.3389/fimmu.2022.927153
10.1186/s12943-023-01775-1
10.1038/s41419-023-05829-6
10.1038/s41591-023-02593-0
10.1016/j.biomaterials.2023.122096
10.1038/s41573-023-00807-1
10.1038/s41409-022-01756-w
10.1080/14787210.2022.2128762
10.1182/blood.2021011895
10.1182/bloodadvances.2022007317
10.1182/blood.2023021306
10.3389/fimmu.2024.1354825
10.1073/pnas.2200626120
10.1016/j.cell.2021.11.016
10.1186/s13045-022-01328-x
10.1186/s12967-022-03813-w
10.1038/s41591-022-02003-x
10.1186/s13045-023-01435-3
10.1038/s41591-023-02785-8 | [
"Huang",
"Li",
"Zhang"
] | [
"Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing, China.",
"Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing, China.",
"Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing, China."
] | [
"38961667",
"35691818",
"37863088",
"36346962",
"37527906",
"33833386",
"37039305",
"37803455",
"34289026",
"35392217",
"36216148",
"34496014",
"35927951",
"36949946",
"22443895",
"14724295",
"20585380",
"29385370",
"29226797",
"30501490",
"29385376",
"30518502",
"25317870",
"25319501",
"27111235",
"32888407",
"24553386",
"32401634",
"32667831",
"33020647",
"32702097",
"32286905",
"31959992",
"32961131",
"32327504",
"33417474",
"32029687",
"32556247",
"33089218",
"32045475",
"32245502",
"31859245",
"32076701",
"31924795",
"32361713",
"31591467",
"32849651",
"31999649",
"32023374",
"31697824",
"37358555",
"35371087",
"36750666",
"31923107",
"37168849",
"33272302",
"36963592",
"34906583",
"34920118",
"35606821",
"33717147",
"36313336",
"33995389",
"37569693",
"35303871",
"36681183",
"35757715",
"37173782",
"37142568",
"37857711",
"37075614",
"37907724",
"35840746",
"36148506",
"34699592",
"35349631",
"37883795",
"38449862",
"36853939",
"34861191",
"35978372",
"36510315",
"36175679",
"37029381",
"38238616"
] | [] | 7.78757 | 3.973706 |
38961233 | 769 | Just scratching the surface: novel treatment approaches for multiple myeloma targeting cell membrane proteins. | A better understanding of the roles of the adaptive and innate immune systems in the oncogenesis of cancers including multiple myeloma (MM) has led to the development of novel immune-based therapies. B cell maturation antigen (BCMA), G protein-coupled receptor family C group 5 member D (GPRC5D) and Fc receptor-like protein 5 (FcRL5, also known as FcRH5) are cell-surface transmembrane proteins expressed by plasma cells, and have been identified as prominent immunotherapeutic targets in MM, with promising activity demonstrated in patients with heavily pretreated relapsed and/or refractory disease. Indeed, since 2020, antibody-drug conjugates, bispecific T cell engagers and autologous chimeric antigen receptor T cells targeting BCMA or GPRC5D have been approved for the treatment of relapsed and/or refractory MM. However, responses to these therapies are not universal, and acquired resistance invariably occurs. In this Review, we discuss the various immunotherapeutic approaches targeting BCMA, GPRC5D and FcRL5 that are currently either available or in clinical development for patients with MM. We also review the mechanisms underlying resistance to such therapies, and discuss potential strategies to overcome these mechanisms and improve patient outcomes. | [
-0.0026294009294360876,
0.012921100482344627,
0.06771591305732727,
0.04403747245669365,
-0.03730030357837677,
0.006211594678461552,
0.000585506553761661,
0.009423429146409035,
-0.0035191865172237158,
-0.003927965182811022,
0.021932676434516907,
-0.028448550030589104,
-0.00884560588747263,
0.029702549800276756,
0.02810431644320488,
0.014285746030509472,
0.03194007650017738,
0.04106229916214943,
-0.003113481216132641,
0.06712579727172852,
0.03666101023554802,
0.02601431868970394,
-0.005443213507533073,
-0.0023358792532235384,
-0.04688970372080803,
-0.015957742929458618,
-0.021649911999702454,
0.004767037928104401,
-0.0304401945322752,
0.004659464582800865,
0.02030985616147518,
-0.032456427812576294,
-0.028669845312833786,
-0.003245642874389887,
-0.050454992800951004,
0.0017350050620734692,
0.0077514308504760265,
0.01957220956683159,
0.011033955961465836,
0.019412385299801826,
0.013683334924280643,
0.01192527823150158,
0.0012524615740403533,
0.03712818771600723,
-0.04091477021574974,
0.01321615930646658,
-0.0006058686994947493,
-0.05763474851846695,
0.007923548109829426,
-0.025166025385260582,
-0.03781665489077568,
0.014261157251894474,
-0.008347694762051105,
0.052274517714977264,
-0.04814369976520538,
0.008568989112973213,
-0.010118045844137669,
0.010591368190944195,
0.013326806016266346,
-0.023174380883574486,
0.004462759010493755,
-0.01541680283844471,
-0.01793709397315979,
-0.01857638731598854,
-0.053700633347034454,
-0.017580565065145493,
-0.02601431868970394,
-0.027563374489545822,
0.008999282494187355,
-0.019559916108846664,
0.014482451602816582,
-0.049422286450862885,
0.027292905375361443,
0.02316208742558956,
0.0050805374048650265,
0.008015753701329231,
-0.0073703136295080185,
0.006731020752340555,
-0.0355791300535202,
-0.016129860654473305,
0.012269512750208378,
0.010536044836044312,
0.0016427993541583419,
-0.04027547687292099,
0.01581021398305893,
0.052913811057806015,
0.01574874483048916,
-0.01171627826988697,
-0.06048697978258133,
0.010179515928030014,
0.0017426888225600123,
-0.015761038288474083,
-0.05606110394001007,
0.07671519368886948,
-0.03609548136591911,
-0.002037747297435999,
0.010253280401229858,
-0.05389733985066414,
0.015552038326859474,
0.06284744292497635,
0.0067556085996329784,
0.0041215973906219006,
-0.019621385261416435,
-0.007075255271047354,
0.06712579727172852,
-0.045143939554691315,
-0.023629263043403625,
-0.01620362512767315,
0.002996687311679125,
0.030391018837690353,
0.05325804650783539,
0.02097373642027378,
-0.03198925033211708,
0.03107948787510395,
-0.013584981672465801,
-0.034521836787462234,
-0.04081641510128975,
-0.0019148063147440553,
-0.02482178993523121,
0.02242444083094597,
-0.03371042758226395,
0.05915921553969383,
0.01954762078821659,
-0.05556933954358101,
-0.009706192649900913,
-0.0026724303606897593,
0.07435472309589386,
-0.02378908544778824,
-0.04428335279226303,
-0.07322366535663605,
0.06333921104669571,
-0.03848053887486458,
0.028522314503788948,
-0.043988294899463654,
-0.05945427343249321,
0.018318211659789085,
-0.010751191526651382,
-0.019977914169430733,
-0.04093935713171959,
-0.0009197524632327259,
-0.003596024587750435,
-0.020986031740903854,
0.013093218207359314,
0.004315229598432779,
-0.025350436568260193,
-0.051733579486608505,
-0.003058157628402114,
0.00048600119771435857,
-0.009380399249494076,
-0.0020362106151878834,
-0.0304401945322752,
0.03149748966097832,
0.013080923818051815,
-0.0037435537669807673,
-0.03498901426792145,
-0.0660930871963501,
0.01659703627228737,
0.093238465487957,
-0.019080445170402527,
-0.051340166479349136,
-0.0284977275878191,
0.018281329423189163,
-0.01175930816680193,
-0.01963368058204651,
0.056651219725608826,
0.04885675758123398,
-0.033735014498233795,
0.03936571255326271,
-0.03324325010180473,
0.03420219197869301,
0.025473378598690033,
0.003860347904264927,
-0.0815836563706398,
-0.05404486879706383,
-0.057192157953977585,
-0.011648661457002163,
0.017494507133960724,
-0.007130578625947237,
-0.06260156631469727,
-0.02072785422205925,
-0.0017257845029234886,
0.012269512750208378,
0.04482429474592209,
-0.0466192327439785,
-0.03712818771600723,
0.024834085255861282,
-0.020481973886489868,
0.017039624974131584,
-0.012798159383237362,
-0.002194497035816312,
0.011962160468101501,
0.022571969777345657,
0.055864397436380386,
0.010566780343651772,
0.008304665796458721,
0.0015936228446662426,
0.03678395226597786,
-0.005587669089436531,
-0.008790282532572746,
-0.0009781494736671448,
0.03316948562860489,
-0.04548817500472069,
0.006620373576879501,
-0.03417760133743286,
-0.050454992800951004,
-0.0005497768288478255,
0.011599484831094742,
0.021342560648918152,
-0.027096198871731758,
0.05001240596175194,
0.04123441502451897,
0.015883978456258774,
0.039685361087322235,
-0.003267157357186079,
-0.02812890335917473,
-0.027366669848561287,
-0.036464303731918335,
0.01696586050093174,
0.012226483784615993,
0.022227736189961433,
0.05630698427557945,
0.027883021160960197,
-0.00016606641293037683,
0.02324814535677433,
-0.02576843649148941,
0.010597515851259232,
-0.0018226004904136062,
-0.02630937658250332,
-0.013818570412695408,
0.01274898275732994,
-0.024121027439832687,
-0.01295798271894455,
0.01626509614288807,
-0.026530670002102852,
-0.046570055186748505,
-0.015158627182245255,
-0.005716757383197546,
0.037619952112436295,
0.06909284740686417,
-0.014162804931402206,
0.025866789743304253,
0.022055618464946747,
0.05689710006117821,
-0.0007372619002126157,
-0.0115011315792799,
0.02209250070154667,
-0.0015091008972376585,
-0.05817568674683571,
0.050700873136520386,
0.0031073340214788914,
-0.00351303955540061,
0.018809976056218147,
-0.01799856498837471,
0.01659703627228737,
-0.001899438677355647,
-0.005639919079840183,
0.00022033334244042635,
0.017469918355345726,
-0.011796190403401852,
-0.002199107315391302,
-0.03779206797480583,
0.04393911734223366,
-0.015072568319737911,
-0.0003793882788158953,
-0.03980829939246178,
0.01766662299633026,
-0.02616184763610363,
-0.00045526595204137266,
0.07396131753921509,
-0.00029390587587840855,
0.007653078064322472,
0.019596798345446587,
0.00789281353354454,
0.001412284909747541,
-0.04337358847260475,
0.00890707690268755,
0.0005424772389233112,
0.02731749415397644,
0.024514438584446907,
0.015035686083137989,
-0.0069031380116939545,
-0.022141676396131516,
0.03223513439297676,
-0.020383620634675026,
-0.010443839244544506,
0.020236091688275337,
0.016609331592917442,
-0.029432078823447227,
-0.04637334868311882,
-0.021600736305117607,
-0.00848293025046587,
0.01013648696243763,
-0.021010618656873703,
-0.02388743869960308,
0.002097681164741516,
0.00517581682652235,
0.01015492808073759,
-0.06397850066423416,
-0.03371042758226395,
0.08020671457052231,
-0.043447352945804596,
0.024108732119202614,
-0.047897819429636,
-0.038283832371234894,
-0.014273451641201973,
0.0007276571122929454,
-0.004644096828997135,
-0.04270970821380615,
0.014802098274230957,
0.04492264613509178,
0.03343995660543442,
-0.03742324560880661,
0.028030551970005035,
0.009718487039208412,
-0.012165013700723648,
0.013646452687680721,
0.019781209528446198,
-0.031669605523347855,
0.0017642035381868482,
-0.030268076807260513,
-0.023592380806803703,
0.0027415845543146133,
-0.05404486879706383,
-0.003479230683296919,
-0.005968786310404539,
-0.040865592658519745,
0.0006435193936340511,
-0.021440912038087845,
0.011470397002995014,
-0.06127380207180977,
0.0459553524851799,
-0.016191331669688225,
0.034251365810632706,
-0.017654329538345337,
-0.009448016993701458,
-0.0035437748301774263,
-0.007493254728615284,
-0.0038080979138612747,
0.007278108038008213,
-0.01405215822160244,
-0.0259159654378891,
0.029997607693076134,
-0.03083360567688942,
0.027784669771790504,
0.0330219566822052,
-0.0050805374048650265,
-0.004453538451343775,
0.04858629032969475,
-0.030095960944890976,
0.043963707983493805,
0.03641512989997864,
0.01681833155453205,
0.03351372107863426,
0.006933873053640127,
-0.012238778173923492,
-0.015293861739337444,
0.03442348539829254,
-0.03860347718000412,
0.012275660410523415,
-0.005799742415547371,
-0.023211263120174408,
-0.0017703506164252758,
-0.014334922656416893,
0.030464783310890198,
0.06924037635326385,
0.056405335664749146,
0.011624072678387165,
-0.00640522688627243,
-0.032063014805316925,
0.004007876850664616,
-0.023137498646974564,
0.028546903282403946,
0.0002604812616482377,
0.011126161552965641,
-0.03479230776429176,
0.033882543444633484,
-0.008169430308043957,
-0.010204103775322437,
-0.002235989784821868,
0.014420980587601662,
0.024723438546061516,
-0.007431784179061651,
0.021440912038087845,
-0.017912505194544792,
0.00330096622928977,
0.04477511718869209,
-0.00920828152447939,
-0.029186196625232697,
-0.07450225204229355,
0.025866789743304253,
-0.01820756494998932,
-0.029210785403847694,
-0.016892096027731895,
0.011040102690458298,
-0.030513959005475044,
0.023137498646974564,
-0.013634158298373222,
0.05556933954358101,
0.05202863737940788,
0.026530670002102852,
-0.018834562972187996,
-0.03693148121237755,
0.0021975706331431866,
-0.027120787650346756,
-0.021342560648918152,
-0.017777271568775177,
0.005317199043929577,
-0.003081209259107709,
0.03147289901971817,
-0.027292905375361443,
-0.02242444083094597,
0.035431601107120514,
0.0369068942964077,
0.012785865925252438,
-0.00842145923525095,
0.0012685975525528193,
-0.03732489049434662,
0.025965142995119095,
0.009109929203987122,
0.011796190403401852,
-0.005258801858872175,
-0.013068629428744316,
0.03184172138571739,
-0.005762860178947449,
0.013474334962666035,
0.00021937287237960845,
0.018711622804403305,
-0.00883331149816513,
-0.020236091688275337,
-0.038013361394405365,
-0.044234175235033035,
0.06491285562515259,
0.02391202747821808,
0.01301945373415947,
0.0031780251301825047,
0.030489372089505196,
-0.030218901112675667,
0.010671280324459076,
-0.03712818771600723,
0.014334922656416893,
-0.040890179574489594,
-0.00535715464502573,
-0.045291468501091,
-0.022301500663161278,
0.0020100856199860573,
0.0713057890534401,
-0.006528167985379696,
0.024834085255861282,
-0.02707161195576191,
0.016338860616087914,
0.01294568832963705,
-0.06850273162126541,
0.03872641921043396,
0.0177895650267601,
-0.049151819199323654,
-0.0006243098177947104,
0.08246883004903793,
-0.016228213906288147,
-0.00928819365799427,
-0.009097634814679623,
0.04049677029252052,
-0.06747002899646759,
0.020199209451675415,
-0.038652654737234116,
-0.047356877475976944,
-0.0021852764766663313,
0.012404748238623142,
0.005268022418022156,
0.004991405177861452,
-0.05350393056869507,
0.04275888577103615,
0.0181215051561594,
-0.017224036157131195,
-0.004886905197054148,
-0.024416085332632065,
0.05429075285792351,
0.02182202972471714,
-0.003288672072812915,
0.039955828338861465,
0.0020285267382860184,
0.012933394871652126,
0.01015492808073759,
-0.0018825342413038015,
-0.02473573200404644,
-0.0024972392711788416,
0.026260200887918472,
-0.045119352638721466,
0.022694911807775497,
-0.005501610226929188,
0.020260678604245186,
0.0008974694064818323,
-0.016523271799087524,
0.016707682982087135,
-0.012060513719916344,
0.0007745283655822277,
-0.05493004620075226,
-0.00781290140002966,
-0.05493004620075226,
-0.04588158801198006,
0.021256500855088234,
-0.04494723305106163,
0.02603890746831894,
-0.00580588961020112,
0.02485867217183113,
0.02458820305764675,
0.03292360529303551,
0.003761995118111372,
0.004247611854225397,
0.0015252369921654463,
0.028202667832374573,
-0.03754618391394615,
-0.010542191565036774,
-0.004481200128793716,
-0.014015275985002518,
-0.01508486270904541,
-0.01948615163564682,
-0.03907065466046333,
-0.02260885201394558,
-0.005876580253243446,
0.008931664749979973,
0.016043802723288536,
0.003208760404959321,
-0.004038612358272076,
0.010480721481144428,
0.0009704656549729407,
-0.02810431644320488,
-0.020764736458659172,
0.0013915386516600847,
-0.02798137441277504,
-0.05650369077920914,
-0.013953804969787598,
0.0010035060113295913,
0.006356050260365009,
0.028153492137789726,
-0.02258426509797573,
-0.01833050511777401,
-0.029948430135846138,
0.004760890733450651,
-0.016609331592917442,
-0.03417760133743286,
0.007548578083515167,
-0.0284731388092041,
0.018256740644574165,
0.006589638534933329,
0.0031933928839862347,
0.04622581973671913,
-0.00887634139508009,
0.007118284702301025,
0.006651109084486961,
0.007290401961654425,
0.04583241045475006,
-0.008212460204958916,
-0.004124671220779419,
-0.017924800515174866,
0.02492014318704605,
-0.02391202747821808,
-0.02297767624258995,
-0.004090862348675728,
0.013498923741281033,
-0.01405215822160244,
0.014150510542094707,
0.003725112648680806,
0.029210785403847694,
-0.013425158336758614,
-0.0014199686702340841,
-0.0010127265704795718,
0.000031191480957204476,
0.020592620596289635,
-0.018293622881174088,
0.011857660487294197,
0.019314033910632133,
0.03292360529303551,
-0.011255249381065369,
-0.015158627182245255,
0.007536284159868956,
-0.009964369237422943,
-0.0061593446880578995,
0.03575124591588974,
-0.011476543731987476,
-0.019436974078416824,
-0.01155030820518732,
-0.02835019864141941,
-0.025571731850504875,
0.023444851860404015,
0.0005382511299103498,
0.0069031380116939545,
-0.0336366631090641,
-0.012546130456030369,
-0.007579313591122627,
0.004853096324950457,
0.02667820081114769,
-0.03587418794631958,
0.023629263043403625,
0.016953565180301666,
-0.0017703506164252758,
0.029628785327076912,
-0.019166504964232445,
0.005934977438300848,
-0.023629263043403625,
-0.002956731477752328,
0.05345475301146507,
-0.020629502832889557,
-0.043447352945804596,
-0.006915431935340166,
-0.008206312544643879,
0.04197206348180771,
0.02506767213344574,
-0.03469395264983177,
-0.003786583198234439,
0.02358008734881878,
0.027145376428961754,
0.05906086415052414,
-0.0316941924393177,
-0.018834562972187996,
-0.00805878359824419,
-0.008064930327236652,
0.0033685837406665087,
0.022313794121146202,
-0.00537252239882946,
-0.008593576960265636,
-0.015367627143859863,
0.031153252348303795,
-0.009982810355722904,
-0.0012286417186260223,
0.022498205304145813,
-0.06501121073961258,
-0.010363927111029625,
-0.007628489751368761,
0.031669605523347855,
-0.0035806570667773485,
-0.013056335970759392,
-0.03730030357837677,
-0.01458080392330885,
0.025018496438860893,
0.025989729911088943,
-0.021858911961317062,
0.05242204666137695,
-0.005864286329597235,
0.016535567119717598,
-0.014900450594723225,
-0.009245164692401886,
0.006651109084486961,
-0.02455132082104683,
-0.0029767092783004045,
0.014679157175123692,
-0.03626760095357895,
0.019412385299801826,
-0.0008790282299742103,
0.004032465163618326,
-0.03272689878940582,
-0.014482451602816582,
-0.011046250350773335,
0.008771841414272785,
-0.008999282494187355,
0.02630937658250332,
-0.006841667462140322,
-0.007394901942461729,
0.030931958928704262,
0.054979220032691956,
0.0531105175614357,
-0.04418500140309334,
-0.008808723650872707,
-0.004401288460940123,
-0.02440379187464714,
-0.0024757247883826494,
0.008624312467873096,
0.0007361093303188682,
0.0042383912950754166,
0.007001490797847509,
0.0028076653834432364,
0.07105990499258041,
-0.02091226726770401,
0.005142007954418659,
0.03004678338766098,
0.02682572975754738,
0.030661489814519882,
0.012908806093037128,
-0.007394901942461729,
-0.032972779124975204,
0.019387798383831978,
0.02130567841231823,
-0.0014330311678349972,
-0.039464063942432404,
-0.07046978920698166,
0.0067556085996329784,
-0.006128609646111727,
0.022350676357746124,
-0.0006938483566045761,
0.01636344939470291,
-0.010173369199037552,
0.02142861858010292,
-0.02603890746831894,
-0.012275660410523415,
0.0020730928517878056,
0.0047147879377007484,
-0.023198969662189484,
-0.021588442847132683,
0.0034362012520432472,
-0.03717736154794693,
-0.023235851898789406,
0.043816179037094116,
-0.0008467562147416174,
0.026530670002102852,
0.010898720473051071,
0.034497249871492386,
-0.022694911807775497,
-0.05222534388303757,
0.0009889068314805627,
0.006242330186069012,
0.01578562706708908,
-0.029702549800276756,
0.011033955961465836,
-0.03493983671069145,
-0.015896273776888847,
0.01930173859000206,
-0.012896512635052204,
-0.005307978484779596,
0.041750770062208176,
0.0045856996439397335,
-0.0022421367466449738,
0.008919370360672474,
-0.0024495997931808233,
-0.02498161420226097,
-0.0011141529539600015,
0.0738137885928154,
0.02464967407286167,
-0.04767652601003647,
0.04005418345332146,
-0.03663642331957817,
-0.0015782553236931562,
-0.012613748200237751,
-0.004785479046404362,
0.006180859636515379,
0.00014820155047345906,
0.004183067940175533,
0.028817374259233475,
0.017506800591945648,
-0.035013601183891296,
-0.034890659153461456,
-0.007112137507647276,
0.04659464582800865,
-0.02643231861293316,
-0.04376700147986412,
-0.002609423128888011,
-0.01253383606672287,
0.019461562857031822,
0.028719021007418633,
-0.00412774458527565,
0.019068151712417603,
-0.0006454403046518564,
-0.018441151827573776,
0.009577104821801186,
-0.013191570527851582,
-0.00845219474285841,
-0.007290401961654425,
-0.016092978417873383,
0.003574509872123599,
0.01663391850888729,
-0.0633883848786354,
-0.026874905452132225,
-0.030784429982304573,
0.01903126947581768,
-0.012042072601616383,
-0.022203147411346436,
-0.020531149581074715,
0.009607840329408646,
-0.008403018116950989,
0.011765454895794392,
0.021207325160503387,
0.024698849767446518,
0.011433514766395092,
-0.014740627259016037,
0.009613987058401108,
-0.05065169930458069,
0.019744327291846275,
0.02012544311583042,
-0.007825195789337158,
-0.015883978456258774,
-0.0200885608792305,
0.009626281447708607,
0.022658029571175575,
-0.00903001707047224,
0.0061777858063578606,
-0.0057935952208936214,
-0.0077821663580834866,
0.02169908955693245,
0.02434232085943222,
-0.01418739277869463,
-0.0194246806204319,
-0.016314271837472916,
-0.007173608057200909,
0.02734208106994629,
-0.020174620673060417,
0.013769393786787987,
-0.015134038403630257,
0.021231913939118385,
0.02704702317714691,
-0.09987728297710419,
-0.02458820305764675,
-0.01954762078821659,
0.010314751416444778,
-0.042144179344177246,
0.0007065266254357994,
-0.022018736228346825,
-0.01581021398305893,
0.011212220415472984,
-0.0284977275878191,
0.0006185469683259726,
-0.004736302420496941,
0.022719498723745346,
-0.0006884696776978672,
0.029235372319817543,
-0.03766912594437599,
-0.014961921609938145,
-0.02886654995381832,
0.009853722527623177,
0.036070894449949265,
0.03666101023554802,
0.00971234031021595,
-0.03016972541809082,
0.016129860654473305,
-0.020629502832889557,
-0.01424886379390955,
-0.004146185703575611,
-0.01508486270904541,
-0.043201472610235214,
-0.014175099320709705,
0.008796429261565208,
0.03395630791783333,
-0.01253383606672287,
0.02539961412549019,
-0.002850694814696908,
-0.028964903205633163,
-0.001097248517908156,
0.016215920448303223,
0.013437452726066113,
-0.010904868133366108,
-0.016252802684903145,
0.013191570527851582,
0.014371804893016815,
0.03134995698928833,
-0.05114346370100975,
0.0013024064246565104,
-0.002151467837393284,
0.008538253605365753,
0.021563854068517685,
-0.001353887957520783,
-0.016806036233901978,
-0.03784124553203583,
-0.010480721481144428,
0.016732271760702133,
0.008403018116950989,
-0.028055138885974884,
-0.02246132306754589,
0.03533324599266052,
0.013326806016266346,
-0.01866244524717331,
-0.0001743265165714547,
0.01399068720638752,
0.026751965284347534,
-0.005003699101507664,
-0.03265313431620598,
-0.025571731850504875,
-0.0015874758828431368,
0.04676676169037819,
-0.04507017508149147,
0.016154449433088303,
-0.025448789820075035,
0.014211981557309628,
-0.0414557084441185,
0.03427595645189285,
-0.009570958092808723,
-0.01636344939470291,
0.008212460204958916,
-0.011587190441787243,
-0.005815110169351101,
0.029186196625232697,
-0.02479720301926136,
-0.027022434398531914,
-0.020408207550644875,
0.00596263911575079,
-0.017555976286530495,
-0.0034853776451200247,
-0.013978393748402596,
-0.002835327060893178,
-0.0010565243428573012,
-0.012589159421622753,
0.0058427718468010426,
-0.027563374489545822,
0.005040581803768873,
0.021465500816702843,
0.023297322914004326,
-0.025424201041460037,
0.0007080634240992367,
-0.003918744623661041,
-0.00038246181793510914,
-0.0077821663580834866,
0.03275148570537567,
-0.013326806016266346,
-0.012060513719916344,
-0.03584960103034973,
0.005590742453932762,
-0.037374068051576614,
-0.010296310298144817,
-0.00430908240377903,
0.00637449137866497,
-0.004395141266286373,
0.040963947772979736,
0.001953225350007415,
0.027268316596746445,
-0.01236786600202322,
-0.013695629313588142,
0.007308843079954386,
0.027686316519975662,
-0.02060491405427456,
-0.0024326953571289778,
0.02482178993523121,
0.06560132652521133,
0.01611756719648838,
0.01477750949561596,
0.005000625737011433,
0.016166742891073227,
0.0021914236713200808,
0.025473378598690033,
0.05104510858654976,
0.0018856078386306763,
0.007302696350961924,
-0.007714548613876104,
0.038529712706804276,
-0.016879800707101822,
0.0009520244784653187,
-0.00409700907766819,
0.016744565218687057,
-0.010197957046329975,
0.03717736154794693,
0.01161177922040224,
0.028055138885974884,
0.013535805977880955,
-0.005307978484779596,
-0.004093935713171959,
-0.020568031817674637,
0.034374307841062546,
0.010130339302122593,
-0.03575124591588974,
0.03132537007331848,
-0.02409643866121769,
-0.0106958681717515,
-0.004668685141950846,
0.009890604764223099,
0.013806276023387909,
0.05517592653632164,
0.016019213944673538,
0.022805558517575264,
-0.011175338178873062,
-0.021293383091688156,
-0.009792251512408257,
0.012017483823001385,
-0.027760080993175507,
0.04219335690140724,
-0.02562090754508972,
-0.04179994389414787,
-0.014371804893016815,
-0.02015003189444542,
-0.017101095989346504,
-0.0033778042998164892,
0.041529472917318344,
0.005722904112190008,
0.016892096027731895,
-0.06766673177480698,
0.07435472309589386,
-0.017764976248145103,
-0.03272689878940582,
0.007382608018815517,
0.008900929242372513,
-0.003934112377464771,
0.022953087463974953,
0.028030551970005035,
-0.0005835856427438557,
0.004687126260250807,
0.0407918281853199,
0.036316774785518646,
0.030612312257289886,
-0.04659464582800865,
-0.007173608057200909,
-0.013474334962666035,
-0.00409700907766819,
-0.011095426976680756,
-0.007075255271047354,
-0.011310573667287827,
0.0284731388092041,
0.060142744332551956,
0.04143112152814865,
-0.02415790967643261,
-0.01399068720638752,
0.05345475301146507,
-0.015465979464352131,
-0.04061971232295036,
-0.02640772983431816,
0.03041560761630535,
0.05028287321329117,
-0.01220189593732357,
-0.033735014498233795,
0.002790760947391391,
0.03417760133743286,
-0.026653612032532692,
-0.022682616487145424,
0.09166482090950012,
-0.005523125175386667,
0.03238266333937645,
-0.0381854772567749,
-0.008532105945050716,
0.03201384097337723,
-0.018994387239217758,
-0.02316208742558956,
0.006122462451457977,
-0.02835019864141941,
0.000004595280643115984,
-0.0017073433846235275,
-0.037742890417575836,
0.013830863870680332,
0.00863660592585802,
0.015121744945645332,
0.004985257983207703,
0.01215271931141615,
0.004176920745521784,
-0.017568271607160568,
0.0014314944855868816,
-0.005224992986768484,
0.05714298412203789,
0.028005963191390038,
0.03189089894294739,
0.016547860577702522,
-0.010284015908837318,
0.007351872511208057,
-0.03002219647169113,
0.017715800553560257,
-0.027268316596746445,
0.018896033987402916,
0.05232369527220726,
-0.026260200887918472,
-0.019129622727632523,
-0.012589159421622753,
-0.008353841491043568,
0.0349644236266613,
-0.021317971870303154,
-0.03080901876091957,
-0.03754618391394615,
0.010960191488265991,
0.006343756336718798,
-0.005876580253243446,
0.059650979936122894,
0.01172857265919447,
0.04347194358706474,
0.002985929837450385,
-0.0027600256726145744,
0.028448550030589104,
-0.009466458112001419,
0.002214475069195032,
-0.02485867217183113,
-0.024293145164847374,
0.011919131502509117,
0.005673727951943874,
-0.009798399172723293,
-0.005560007411986589,
-0.03806253895163536,
-0.0025418053846806288,
0.004475052934139967,
0.006251550745218992,
-0.006817079149186611,
-0.028522314503788948,
-0.0011909910244867206,
0.02603890746831894,
-0.015011098235845566,
0.011402779258787632,
-0.04944687709212303,
-0.035308659076690674,
-0.0027938345447182655,
-0.007745284121483564,
0.011783896014094353,
-0.023715320974588394,
0.003974068444222212,
0.0018779239617288113,
0.02467426098883152,
-0.03966077044606209,
-0.016793742775917053,
0.0317433699965477,
-0.027219140902161598,
0.006239256355911493,
0.02630937658250332,
0.020039385184645653,
0.008372282609343529,
-0.0021868133917450905,
-0.03405465930700302,
-0.018834562972187996,
-0.035185717046260834,
0.00786207802593708,
-0.021600736305117607,
-0.0010880279587581754,
0.010111898183822632,
-0.0019547620322555304,
-0.006534314714372158,
0.020346738398075104,
0.006088653579354286,
-0.018650151789188385,
-0.03830841928720474,
0.03589877486228943,
-0.027096198871731758,
-0.034374307841062546,
-0.009343517012894154,
0.009183693677186966,
-0.0005693705752491951,
-0.0004756280395668,
-0.011144602671265602,
-0.012982571497559547,
0.030931958928704262,
0.008439900353550911,
0.002922922605648637,
-0.006211594678461552,
0.00578130129724741,
-0.009724633768200874,
0.02898949198424816,
-0.003967921249568462,
-0.01578562706708908,
-0.004060126841068268,
-0.01438409835100174,
-0.004699420183897018,
-0.008734959177672863,
0.02822725661098957,
0.0018594828434288502,
-0.002326658694073558,
-0.0037128187250345945,
0.03380877897143364,
0.020371325314044952,
-0.027784669771790504,
0.009294340386986732,
0.0336858369410038,
-0.010591368190944195,
0.006460550241172314,
0.0035007453989237547,
0.028546903282403946,
0.015441391617059708,
0.01438409835100174,
0.004659464582800865,
0.019375503063201904,
0.0032179809641093016,
-0.008888635784387589,
-0.019682856276631355,
0.059257570654153824,
-0.012515394948422909,
-0.007278108038008213,
0.019658267498016357,
0.0242808498442173,
0.009140664711594582,
0.016006920486688614,
0.03196466341614723,
0.007149019744247198,
-0.0009704656549729407,
-0.014211981557309628,
0.03371042758226395,
0.02182202972471714,
-0.007972724735736847,
0.0016566301928833127,
0.0067556085996329784,
-0.01733468286693096,
0.01405215822160244,
0.0026109598111361265,
0.023875145241618156,
-0.013449747115373611,
0.006399079691618681,
-0.0047301556915044785,
-0.0004318303253967315,
-0.0021898867562413216,
-0.0013500460190698504,
0.05104510858654976,
-0.006589638534933329,
0.002345099812373519,
0.03484148159623146,
-0.009687751531600952,
0.009343517012894154,
0.005639919079840183,
-0.012662924826145172,
-0.0021822031121701,
-0.022756380960345268,
-0.013240747153759003,
-0.0016996595077216625,
0.023752203211188316,
0.0014829760184511542,
0.014568510465323925,
0.005938050802797079,
0.02351861633360386,
0.008384576998651028,
-0.0016689242329448462,
0.002607886213809252,
-0.006589638534933329,
0.023469438776373863,
-0.007130578625947237,
-0.001632041996344924,
-0.017531389370560646,
-0.026850316673517227,
0.02133026532828808,
0.015121744945645332,
0.017703505232930183,
0.007603901904076338,
-0.010118045844137669,
0.03390713036060333,
-0.007696107495576143,
0.0030059078708291054,
-0.006337609142065048,
-0.0002633627154864371,
-0.026579847559332848,
0.024256262928247452,
-0.010493015870451927,
-0.008495223708450794,
0.00971234031021595,
-0.016953565180301666,
-0.048635464161634445,
0.0011325940722599626,
-0.014728333801031113,
-0.043693237006664276,
0.011341308243572712,
0.01669538952410221,
-0.01882226951420307,
-0.017912505194544792,
0.0048469495959579945,
0.005249581299722195,
-0.0065711974166333675,
-0.007290401961654425,
0.03612006828188896,
-0.02161302976310253,
0.022264618426561356,
-0.002638621488586068,
-0.030981136485934258,
0.012546130456030369,
-0.011900690384209156,
-0.012423189356923103,
-0.0375215969979763,
-0.002809202065691352,
0.01180848479270935,
0.0543891042470932,
0.009343517012894154,
0.02027297392487526,
0.015834802761673927,
-0.02254738286137581,
-0.002818422857671976,
0.002389665925875306,
0.032161369919776917,
-0.007130578625947237,
0.007296549156308174,
-0.007954283617436886,
-0.009583252482116222,
-0.0004356722056400031,
-0.04998781532049179,
0.0005459349486045539,
-0.029973018914461136,
-0.009915192611515522,
0.027489610016345978,
0.03250560536980629,
-0.022473616525530815,
-0.021391736343503,
0.0060609919019043446,
0.003227201523259282,
0.01482668612152338,
-0.005317199043929577,
-0.008704223670065403,
0.016584742814302444,
0.0020408208947628736,
-0.019314033910632133,
0.029309138655662537,
0.03405465930700302,
0.0006496664136648178,
0.007646930869668722,
-0.01802315190434456,
-0.016879800707101822,
0.016744565218687057,
0.010874132625758648,
-0.013302218168973923,
0.0070383730344474316,
-0.01917879842221737,
0.04361947253346443,
-0.004511935170739889,
-0.01630197837948799,
0.0006054844707250595,
0.007112137507647276,
0.011415072716772556,
-0.021072089672088623,
0.01917879842221737,
0.01860097609460354,
-0.029628785327076912,
0.008568989112973213,
-0.011494984850287437,
0.0006746388389728963,
-0.005191184114664793,
0.011654808185994625,
-0.0349644236266613,
-0.04143112152814865,
-0.016277389600872993,
0.03552995249629021,
-0.01785103604197502,
0.007407196331769228,
-0.015711860731244087,
-0.006187006365507841,
0.013068629428744316,
-0.022559676319360733,
-0.03083360567688942,
-0.050504170358181,
-0.018109211698174477,
-0.003746627364307642,
-0.01948615163564682,
-0.0012685975525528193,
-0.016941271722316742,
0.021785147488117218,
0.04093935713171959,
0.02021150290966034,
-0.006156271323561668,
0.046422526240348816,
-0.003359363181516528,
0.0011664028279483318,
0.021785147488117218,
0.009202134795486927,
0.007124431896954775,
-0.007431784179061651,
-0.052913811057806015,
0.005621477961540222,
-0.008630459196865559,
0.023838263005018234,
-0.012244924902915955,
0.014310333877801895,
0.01954762078821659,
0.0008352305158041418,
0.0382346548140049,
-0.03211219236254692,
-0.011587190441787243,
0.0050989785231649876,
0.039291948080062866,
0.011679396033287048,
-0.010788073763251305,
0.009626281447708607,
-0.011193779297173023,
0.029235372319817543,
0.006712579168379307,
-0.01699044741690159,
0.0021637617610394955,
-0.006122462451457977,
0.0672733262181282,
0.005556934047490358,
0.012613748200237751,
0.014912744984030724,
0.027563374489545822,
-0.018355093896389008,
-0.03353830799460411,
-0.0018502622842788696,
-0.005114346276968718,
-0.01443327497690916,
-0.01502339169383049,
0.01924026943743229,
-0.009226723574101925,
0.03356289863586426,
0.005722904112190008,
-0.008298518136143684,
0.01593315601348877,
0.010339339263737202,
-0.0010657449020072818,
-0.00638063857331872,
0.006681844126433134,
0.0317433699965477,
-0.023211263120174408,
0.016978153958916664,
-0.02413332089781761,
-0.024379203096032143,
0.009927487000823021,
-0.026579847559332848,
-0.038677241653203964,
0.015158627182245255,
0.00014945017755962908,
-0.005673727951943874,
0.008980841375887394,
0.003230275120586157,
-0.00020208429486956447,
-0.008593576960265636,
-0.043570294976234436,
0.022891616448760033,
0.010480721481144428,
-0.018932916224002838,
-0.0090730469673872,
-0.03572665899991989,
-0.004945302382111549,
0.0032733045518398285,
-0.033095721155405045,
-0.040103357285261154,
0.011833072640001774,
-0.005157375708222389,
0.028940314427018166,
0.013843158259987831,
0.0008329253760166466,
-0.025940554216504097,
-0.03157125413417816,
0.002156078116968274,
0.0317433699965477,
0.027243727818131447,
-0.004859243519604206,
-0.011230661533772945,
0.02415790967643261,
-0.0069031380116939545,
-0.011906837113201618,
-0.0258913766592741,
-0.02006397396326065,
0.01775268279016018,
-0.004035538993775845,
0.004628729075193405,
-0.006983049679547548,
0.019068151712417603,
-0.0028199595399200916,
0.027760080993175507,
-0.04949605092406273,
0.0035990981850773096,
0.014802098274230957,
-0.01132286712527275,
0.013166982680559158,
0.009767663665115833,
-0.011494984850287437,
-0.00174883590079844,
-0.029579607769846916,
0.04061971232295036,
-0.013511217199265957,
-0.03378419205546379,
0.02810431644320488,
0.0004967585555277765,
-0.043717823922634125,
-0.007505549117922783,
0.011962160468101501,
-0.00029582681600004435,
-0.027563374489545822,
-0.03621842339634895,
0.0003177256730850786,
0.021195031702518463,
-0.023198969662189484,
0.031054900959134102,
-0.001176391844637692,
0.0033501426223665476,
-0.03466936573386192,
-0.014457862824201584,
0.0003830381028819829,
0.030661489814519882,
-0.028792785480618477,
-0.053159695118665695,
-0.016080684959888458,
-0.018613269552588463,
-0.03107948787510395,
0.025547143071889877,
0.016978153958916664,
0.026260200887918472,
0.03403007239103317,
0.03176795691251755,
-0.0019071224378421903,
0.02862066775560379,
-0.03427595645189285,
-0.006927726324647665,
0.03857889026403427,
-0.004558037966489792,
0.013375982642173767,
0.032579369843006134,
0.015379920601844788,
-0.020100856199860573,
0.009005429223179817,
0.00887634139508009,
-0.010216398164629936,
0.003081209259107709,
-0.03742324560880661,
-0.004462759010493755,
-0.016646213829517365,
0.01444556936621666,
0.09800857305526733,
-0.01276127714663744,
-0.008741105906665325,
0.029727136716246605,
-0.00805878359824419,
-0.023137498646974564,
0.008458341471850872,
-0.02512914314866066,
-0.000021730784283136018,
-0.007265814114362001,
-0.0008867120486684144,
0.02967796102166176,
0.023112909868359566,
0.04996322840452194,
0.010419251397252083,
0.006313021294772625,
-0.004650244023650885,
0.01438409835100174,
-0.019105033949017525,
-0.02145320735871792,
-0.0015152479754760861,
0.011052397079765797,
0.006651109084486961,
0.028546903282403946,
-0.021207325160503387,
-0.00005762860018876381,
-0.012613748200237751,
-0.017592858523130417,
-0.007646930869668722,
-0.02744043432176113,
0.015552038326859474,
-0.023358792066574097,
0.030907370150089264,
-0.03184172138571739,
0.01169783715158701,
0.013572688214480877,
-0.011863808147609234,
-0.014703745022416115,
-0.006503579672425985,
-0.0022190853487700224,
0.006131683010607958,
0.013560393825173378,
-0.010314751416444778,
0.005449360236525536,
0.003531480673700571,
0.0007314990507438779,
0.008169430308043957,
0.005639919079840183,
0.012675218284130096,
-0.027686316519975662,
0.0135972760617733,
-0.011464249342679977,
0.00017691979883238673,
-0.01077578030526638,
-0.00020727085939142853,
-0.00207155616953969,
0.00863660592585802,
0.016941271722316742,
-0.00926975253969431,
-0.02731749415397644,
-0.0226703230291605,
0.019338620826601982,
0.023924320936203003,
-0.000754934677388519,
0.03454642370343208
] | 2024-07-04 | 114 | 38961233 | [
"autologous chimeric antigen receptor T cells",
"bispecific T cell engagers",
"B cell maturation antigen",
"plasma cells",
"such therapies",
"prominent immunotherapeutic targets",
"MM",
"GPRC5D",
"BCMA",
"clinical development",
"potential strategies",
"cell-surface transmembrane proteins",
"multiple myeloma",
"promising activity",
"resistance",
"FcRL5",
"Fc receptor-like protein",
"G protein-coupled receptor family C group 5 member D",
"patients",
"patient outcomes",
"novel immune-based therapies",
"relapsed and/or refractory MM",
"cancers",
"the various immunotherapeutic approaches",
"Fc",
"FcRH5",
"the adaptive and innate immune systems",
"responses",
"Review",
"heavily pretreated relapsed and/or refractory disease"
] | [] | 0 | 10.1038/s41571-024-00913-y
10.1182/blood-2007-10-078022
10.1182/blood-2014-09-568915
10.1182/blood-2014-11-568923
10.1002/ajh.26590
10.3322/caac.21763
10.3389/fonc.2020.00636
10.3389/fonc.2020.606368
10.1038/s41591-023-02703-y
10.1182/hematology.2023000434
10.1182/hematology.2023000433
10.1016/S0140-6736(19)31774-X
10.1126/science.aar6711
10.1038/s41408-021-00459-7
10.1038/icb.2014.93
10.1016/j.molimm.2005.03.007
10.1038/nature22395
10.1136/bmj.m3176
10.1172/JCI18025
10.1182/blood-2016-01-691162
10.4049/jimmunol.165.3.1322
10.1002/cbf.3169
10.1038/ncomms8333
10.1111/j.1365-2141.2012.09241.x
10.1182/blood-2023-173550
10.1182/blood-2013-10-535088
10.1158/1535-7163.MCT-21-0035
10.1016/S1470-2045(19)30788-0
10.1097/01.HS9.0000936252.25785.17
10.4155/tde-2016-0002
10.1016/S2352-3026(23)00243-0
10.1056/NEJMoa2403407
10.1056/NEJMoa240509
10.1200/JCO.2023.41.16_suppl.8025
10.1007/s40291-023-00673-y
10.1182/blood-2023-184373
10.1056/NEJMoa1817226
10.1056/NEJMoa2024850
10.1200/JCO.2021.39.15_suppl.8016
10.1182/blood-2022-164884
10.1056/NEJMoa2213614
10.1200/JCO.22.00842
10.1200/JCO.2023.41.16_suppl.8009
10.1182/blood-2023-178882
10.1056/NEJMoa2303379
10.1182/blood.2023020571
10.1038/s41591-021-01564-7
10.1182/blood-2022-159156
10.1182/bloodadvances.2022007210
10.1182/blood-2022-160038
10.1038/s41591-022-02182-7
10.1186/s13045-021-01170-7
10.1016/S2352-3026(19)30115-2
10.1056/NEJMoa2203478
10.1200/JCO.2023.41.16_suppl.8011
10.1038/s41591-023-02589-w
10.1038/s41591-023-02528-9
10.1182/blood-2023-182130
10.1080/19420862.2023.2181016
10.1182/bloodadvances.2022009435
10.1038/s41408-023-00879-7
10.1182/blood-2023-177968
10.1182/blood-2023-180013
10.1182/blood-2023-182388
10.1038/nrd.2017.178
10.1126/scitranslmed.aau7746
10.1046/j.0022-202X.2004.12628.x
10.1182/blood.2019003342
10.1016/S0167-4781(01)00197-X
10.1182/blood.2019000050
10.1056/NEJMoa2209900
10.1200/JCO.2024.42.16_suppl.7511
10.1182/blood-2023-181857
10.1200/JCO.22.01824
10.1158/2643-3230.BCD-20-0020
10.1182/blood-2023-181613
10.1182/blood-2022-159289
10.1182/blood-2022-170501
10.1158/1538-7445.AM2022-6020
10.1056/NEJMoa2204591
10.1182/blood-2023-182330
10.1200/JCO.2023.41.16_suppl.8036
10.1182/blood-2023-187242
10.1182/blood-2022-157988
10.1016/S2152-2650(23)01572-0
10.1158/1535-7163.MCT-12-0087
10.1093/intimm/dxl069
10.1038/sj.leu.2404445
10.1016/S1074-7613(01)00109-1
10.1038/leu.2011.204
10.1073/pnas.0703354104
10.1016/j.ccell.2017.02.001
10.1038/s41408-019-0178-8
10.1038/s41467-023-39395-4
10.1038/s41392-023-01702-2
10.1182/blood-2023-183025
10.1182/blood-2021-147983
10.1182/blood-2022-159381
10.1182/blood-2022-157547
10.1200/JCO.23.02232
10.1172/JCI126397
10.1182/blood-2018-99-117729
10.1182/blood-2021-146518
10.1182/blood-2021-148390
10.1200/JCO.2023.41.16_suppl.8004
10.1158/2159-8290.CD-22-1319
10.1016/j.omtm.2022.03.018
10.1182/bloodadvances.2019000600
10.1200/JCO.2021.39.15_suppl.TPS8053
10.1182/blood-2020-137650
10.1158/2643-3230.BCD-22-0018
10.1016/j.ccell.2023.02.008
10.1016/j.jtct.2023.04.007
10.1073/pnas.1819745116
10.1038/s41591-021-01245-5
10.1038/s41467-021-21177-5
10.1038/s41591-023-02491-5
10.1182/bloodadvances.2021004418
10.1182/blood-2022-167602
10.1056/NEJMc2308544
10.1038/s43018-023-00625-9
10.1084/jem.20031330
10.1182/bloodadvances.2023010025
10.1182/blood.2022015526
10.1200/JCO.22.01365
10.1016/S1470-2045(23)00246-2
10.1038/s41408-022-00716-3
10.1200/JCO.2023.41.16_suppl.8006
10.1007/s11523-023-00989-z
10.1182/bloodadvances.2022007625
10.1182/blood-2023-190341
10.1200/JCO.2023.41.16_suppl.8002
10.1038/s41467-024-44873-4
10.1038/s41375-023-02065-x
10.1038/s41467-020-16160-5
10.1038/s41467-023-43416-7
10.1200/JCO.2023.41.16_suppl.TPS8064
10.1016/S2352-3026(21)00057-0
10.1182/blood-2017-04-778423
10.1038/s41434-021-00254-w
10.1016/j.ymthe.2020.10.008
10.1111/imr.12233
10.3390/ijms22094462
10.1186/s13045-016-0345-3
10.1158/1078-0432.CCR-19-2111
10.1007/s12185-023-03579-x
10.1038/leu.2016.84
10.1242/dmm.008961
10.1038/s41590-020-00834-9
10.1038/leu.2010.193
10.1182/bloodadvances.2020003805
10.1136/jitc-2021-003975
10.1158/1078-0432.CCR-19-0101
10.1084/jem.20050732
10.1038/s41408-023-00929-0
10.1038/s41467-019-08711-2
10.1038/s41591-023-02234-6
10.1038/s41467-022-32960-3
10.1097/01.HS9.0000967680.90062.ca
10.1182/blood.2022015956
10.1038/s41591-023-02767-w | [
"Neri",
"Leblay",
"Lee",
"Gulla",
"Bahlis",
"Anderson"
] | [
"Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.",
"Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.",
"Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.",
"Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy.",
"Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.",
"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. [email protected]."
] | [
"38961233",
"18332230",
"25838345",
"25838342",
"35560063",
"36633525",
"32432039",
"33585226",
"38177852",
"38066841",
"31478503",
"29567707",
"33824268",
"25367186",
"16360021",
"28541315",
"32958461",
"12865416",
"27127303",
"10903733",
"26914861",
"26065893",
"22804669",
"24569262",
"34253590",
"31859245",
"26893243",
"37793771",
"38832972",
"38828933",
"37658205",
"31042825",
"33626253",
"36762851",
"35658469",
"37272512",
"37471607",
"34893771",
"35468618",
"36690811",
"34627333",
"31378662",
"35661166",
"37783970",
"37582952",
"36823042",
"36857755",
"37528088",
"29075003",
"30918115",
"15086536",
"32040549",
"11311935",
"31558469",
"36170501",
"36881785",
"33089218",
"36507686",
"16849395",
"17051241",
"11290337",
"21836613",
"17522256",
"28262555",
"37339964",
"38212320",
"30896447",
"37934007",
"35573047",
"31575532",
"36026513",
"36898378",
"30988175",
"33619368",
"33558511",
"37653344",
"34471932",
"37819961",
"37653140",
"14707116",
"37611163",
"36095849",
"36623248",
"37414012",
"35973981",
"37713090",
"36006441",
"38242888",
"37848634",
"32385241",
"37980341",
"34048683",
"29089311",
"33846552",
"33129371",
"25510276",
"33923357",
"27809856",
"31672768",
"36964840",
"27102208",
"23115205",
"33398183",
"20811474",
"33890981",
"35428704",
"31444250",
"16203864",
"37833271",
"30770822",
"36914893",
"36085303",
"35878001",
"38195751"
] | [] | 4.802367 | 6.250401 |
38961036 | 770 | Multiple myeloma: signaling pathways and targeted therapy. | Multiple myeloma (MM) is the second most common hematological malignancy of plasma cells, characterized by osteolytic bone lesions, anemia, hypercalcemia, renal failure, and the accumulation of malignant plasma cells. The pathogenesis of MM involves the interaction between MM cells and the bone marrow microenvironment through soluble cytokines and cell adhesion molecules, which activate various signaling pathways such as PI3K/AKT/mTOR, RAS/MAPK, JAK/STAT, Wnt/β-catenin, and NF-κB pathways. Aberrant activation of these pathways contributes to the proliferation, survival, migration, and drug resistance of myeloma cells, making them attractive targets for therapeutic intervention. Currently, approved drugs targeting these signaling pathways in MM are limited, with many inhibitors and inducers still in preclinical or clinical research stages. Therapeutic options for MM include non-targeted drugs like alkylating agents, corticosteroids, immunomodulatory drugs, proteasome inhibitors, and histone deacetylase inhibitors. Additionally, targeted drugs such as monoclonal antibodies, chimeric antigen receptor T cells, bispecific T-cell engagers, and bispecific antibodies are being used in MM treatment. Despite significant advancements in MM treatment, the disease remains incurable, emphasizing the need for the development of novel or combined targeted therapies based on emerging theoretical knowledge, technologies, and platforms. In this review, we highlight the key role of signaling pathways in the malignant progression and treatment of MM, exploring advances in targeted therapy and potential treatments to offer further insights for improving MM management and outcomes. | [
0.004089059308171272,
0.04999881610274315,
0.044259387999773026,
0.03443657234311104,
-0.04201352596282959,
0.04251260682940483,
0.008784955367445946,
-0.009641332551836967,
-0.009340750053524971,
0.000783358293119818,
0.028833255171775818,
-0.034912966191768646,
-0.032508306205272675,
0.03618335351347923,
0.021142875775694847,
-0.011751082725822926,
0.042966313660144806,
0.014223800972104073,
0.0070892153307795525,
0.039041727781295776,
0.010412639006972313,
0.02663276344537735,
0.005348104052245617,
-0.00656744884327054,
-0.011728397570550442,
0.021040791645646095,
-0.02971798926591873,
0.017365742474794388,
-0.012681188061833382,
-0.020530367270112038,
0.02418273128569126,
-0.021687326952815056,
-0.009232994168996811,
0.002316755475476384,
-0.02810732088983059,
-0.015823127701878548,
0.005467202980071306,
0.02472718246281147,
-0.019917858764529228,
0.04140101745724678,
0.018715528771281242,
-0.015085849910974503,
-0.00609105359762907,
0.056260012090206146,
-0.04133296012878418,
0.00044307595817372203,
-0.004335763864219189,
-0.06229435279965401,
0.039155151695013046,
-0.02738138474524021,
-0.008864354342222214,
0.012749244458973408,
0.014201115816831589,
0.05653223767876625,
-0.02522626332938671,
0.03641020879149437,
0.015199277549982071,
0.007696052081882954,
0.021948210895061493,
-0.04959047958254814,
-0.037363000214099884,
-0.01627683825790882,
-0.0035587861202657223,
-0.007758437190204859,
-0.01904446817934513,
-0.01288535725325346,
-0.02220909297466278,
-0.029014740139245987,
0.015471503138542175,
-0.00007913336594356224,
-0.011427815072238445,
-0.07826493680477142,
-0.0066184913739562035,
0.028084635734558105,
0.008767941035330296,
-0.022594746202230453,
-0.038293104618787766,
0.0004948272253386676,
-0.023161884397268295,
0.0076790377497673035,
0.04387373477220535,
0.008507058024406433,
0.012862672097980976,
0.0012817301321774721,
0.0037175845354795456,
0.045484405010938644,
-0.002495403867214918,
-0.008552429266273975,
-0.07068797945976257,
-0.02271951735019684,
-0.013225640170276165,
-0.011393786408007145,
-0.04732193052768707,
0.05712205916643143,
-0.012442990206182003,
0.016152067109942436,
0.02429615892469883,
-0.05036178603768349,
0.009108223952353,
0.02583877183496952,
0.01374740619212389,
0.03591112792491913,
-0.009879530407488346,
-0.05331089720129967,
0.0362967811524868,
-0.04931825399398804,
-0.01783079467713833,
-0.02860640175640583,
0.03572964295744896,
-0.003984138835221529,
0.08130478858947754,
-0.013860833831131458,
-0.03209996595978737,
0.020564395934343338,
-0.012851329520344734,
-0.046958960592746735,
-0.0071969712153077126,
0.015868499875068665,
0.020802592858672142,
0.022628774866461754,
-0.04398716241121292,
0.04435012862086296,
-0.006437007337808609,
-0.030375869944691658,
0.000940738886129111,
-0.034663427621126175,
0.0700981616973877,
0.016333552077412605,
-0.016662491485476494,
-0.030466610565781593,
0.0203715693205595,
-0.0018034963868558407,
-0.009170608595013618,
-0.04135564714670181,
-0.059753578156232834,
0.0056968932040035725,
-0.03148745745420456,
0.005053192377090454,
-0.02484061010181904,
0.013146240264177322,
-0.017274999991059303,
0.000524601899087429,
0.012862672097980976,
0.027585554867982864,
-0.020496338605880737,
-0.0467321053147316,
0.010253841057419777,
0.01962294802069664,
0.0007170741446316242,
-0.006834003608673811,
-0.003643856616690755,
0.0362287238240242,
0.023161884397268295,
0.02472718246281147,
-0.036682434380054474,
-0.03969960659742355,
-0.027290642261505127,
0.060797110199928284,
-0.018568072468042374,
-0.05226736515760422,
-0.02350216545164585,
0.023910505697131157,
0.0017737216548994184,
-0.00764500955119729,
0.00155253813136369,
0.05417294800281525,
-0.02940039336681366,
0.03144208714365959,
-0.01494973711669445,
0.020144714042544365,
0.01739976927638054,
0.006040011532604694,
-0.06156841665506363,
-0.0234341099858284,
-0.018091676756739616,
-0.024636439979076385,
-0.005322582554072142,
-0.060071174055337906,
-0.07000742107629776,
-0.005427503027021885,
-0.02688230387866497,
0.0015411954373121262,
0.017762737348675728,
0.012726559303700924,
0.01101380493491888,
0.020212769508361816,
-0.030421240255236626,
0.0405389666557312,
0.0010874855797737837,
-0.010310554876923561,
0.003958617802709341,
0.04618765413761139,
0.02719990164041519,
0.021301673725247383,
-0.012465676292777061,
0.011200959794223309,
0.029922159388661385,
0.02095004916191101,
-0.023774392902851105,
-0.027358699589967728,
0.015119878575205803,
-0.0618860125541687,
-0.01288535725325346,
-0.04078850895166397,
-0.03477685526013374,
0.018386589363217354,
-0.00041790923569351435,
0.03001290187239647,
0.005864198785275221,
0.05884615704417229,
0.030421240255236626,
-0.009822816587984562,
0.05607852712273598,
0.02016739919781685,
0.008870026096701622,
-0.03568427264690399,
-0.04890991374850273,
0.02315054088830948,
-0.006340594030916691,
0.022152379155158997,
0.06959907710552216,
0.0090741952881217,
-0.03931395336985588,
0.05380997806787491,
-0.04791175201535225,
-0.013180268928408623,
0.01353189442306757,
-0.0066865477710962296,
0.02045096829533577,
0.028152691200375557,
0.0028725499287247658,
-0.01826181821525097,
0.03203190863132477,
-0.020791251212358475,
-0.05635075271129608,
-0.054581284523010254,
-0.05399146303534508,
0.03126060217618942,
0.055261850357055664,
-0.011223645880818367,
0.05807485058903694,
0.02084796316921711,
0.014779595658183098,
-0.008682871237397194,
-0.016015954315662384,
0.0005235385615378618,
0.010724565014243126,
-0.05494425445795059,
0.014178430661559105,
-0.0025180892553180456,
-0.004463369958102703,
0.01301012746989727,
-0.02633785270154476,
0.020314855501055717,
0.019543549045920372,
-0.015358075499534607,
-0.018216447904706,
0.017876164987683296,
-0.0246137548238039,
0.007735751569271088,
-0.0015482845483347774,
0.041741300374269485,
-0.029513821005821228,
-0.01263581681996584,
-0.045484405010938644,
0.04380567744374275,
-0.0041202520951628685,
-0.02885594218969345,
0.043215855956077576,
-0.030126329511404037,
-0.0033205884974449873,
0.03309812769293785,
-0.022231778129935265,
-0.009465520270168781,
-0.01494973711669445,
0.002839939668774605,
0.0028385217301547527,
0.021698670461773872,
0.011637656018137932,
0.02368365041911602,
0.022016266360878944,
-0.011308715678751469,
0.047458041459321976,
-0.012374933809041977,
-0.01479093823581934,
0.016980087384581566,
-0.0002920756523963064,
-0.00016828023944981396,
-0.03917783871293068,
0.006958773825317621,
-0.006539091933518648,
0.02116556093096733,
-0.015335390344262123,
-0.028583716601133347,
-0.004868872929364443,
0.028084635734558105,
0.006522078067064285,
-0.02928696572780609,
-0.024749867618083954,
0.0723213404417038,
0.0051751271821558475,
0.02651933580636978,
-0.03974497690796852,
-0.05208588019013405,
-0.0015553737757727504,
-0.0010052507277578115,
-0.029014740139245987,
-0.04995344579219818,
0.009125237353146076,
0.012964757159352303,
0.019520863890647888,
-0.057984109967947006,
0.0513145737349987,
0.046777479350566864,
0.0025039108004420996,
-0.0003516250872053206,
-0.0076393382623791695,
-0.003263874677941203,
0.02271951735019684,
-0.04028942808508873,
-0.014564083889126778,
-0.024885980412364006,
-0.04614228382706642,
-0.004057866986840963,
0.023547537624835968,
-0.04131027311086655,
0.008172446861863136,
-0.003439687192440033,
0.018068991601467133,
-0.0406070239841938,
0.027767037972807884,
-0.009896544739603996,
0.03187311068177223,
-0.014870338141918182,
-0.007843507453799248,
-0.019452806562185287,
-0.006913402583450079,
-0.0009308139560744166,
-0.00016863470955286175,
-0.0024074974935501814,
-0.06442678719758987,
-0.008654514327645302,
-0.013826805166900158,
0.018137048929929733,
0.0018205104861408472,
-0.03781671077013016,
-0.014734224416315556,
0.033302295953035355,
-0.027585554867982864,
0.027721667662262917,
0.015494188293814659,
0.013441151939332485,
0.021755384281277657,
0.028152691200375557,
0.010401296429336071,
0.008989124558866024,
-0.0038451903965324163,
-0.011320059187710285,
0.048183977603912354,
0.004522919189184904,
-0.019997257739305496,
-0.010832320898771286,
-0.04076582193374634,
0.03273516148328781,
0.06624162942171097,
0.06596940010786057,
-0.014983764849603176,
-0.029922159388661385,
-0.032326821237802505,
0.014291858300566673,
-0.003144775750115514,
0.026587393134832382,
-0.015789100900292397,
0.001824763952754438,
-0.03572964295744896,
0.028402231633663177,
-0.028765199705958366,
0.009907887317240238,
0.00045902669080533087,
0.007582624442875385,
0.04303437098860741,
-0.01789885014295578,
0.04301168769598007,
-0.0021480321884155273,
-0.01624280959367752,
0.029922159388661385,
-0.009516562335193157,
-0.019725032150745392,
-0.0833011120557785,
0.03234950825572014,
0.02971798926591873,
0.01642429456114769,
-0.010713222436606884,
0.007004144601523876,
-0.04103804752230644,
0.016866661608219147,
-0.04387373477220535,
0.07890012860298157,
0.052993301302194595,
-0.0012654248857870698,
0.0011328565888106823,
-0.04655062407255173,
-0.023592907935380936,
-0.018772242590785027,
-0.000511132413521409,
-0.03763522580265999,
-0.004196815192699432,
-0.025929514318704605,
0.031147176399827003,
0.004528590478003025,
0.0011675937566906214,
0.029423078522086143,
0.033188868314027786,
0.0005366535624489188,
0.0020147550385445356,
-0.03654632344841957,
-0.02738138474524021,
0.02361559309065342,
0.006641176994889975,
0.0024571220856159925,
0.013826805166900158,
-0.03076152317225933,
0.024931352585554123,
0.01466616801917553,
0.006714904680848122,
-0.047095075249671936,
0.0891539677977562,
-0.01133707258850336,
-0.014961079694330692,
-0.0287198293954134,
-0.04010794311761856,
0.06714904308319092,
0.01445065625011921,
-0.0051269205287098885,
0.004718581680208445,
0.009380449540913105,
-0.025929514318704605,
-0.025067465379834175,
-0.015176591463387012,
-0.009590290486812592,
-0.030126329511404037,
0.007911563850939274,
-0.04750341176986694,
-0.03600187227129936,
0.040448226034641266,
0.0308749508112669,
-0.009125237353146076,
0.04836546257138252,
-0.027971208095550537,
-0.0037147486582398415,
0.01738842763006687,
-0.04575663059949875,
0.006624162662774324,
0.02361559309065342,
0.0117170549929142,
-0.02785778045654297,
0.07418154925107956,
-0.03273516148328781,
-0.02282160148024559,
-0.007650680840015411,
0.04337465390563011,
-0.03597918525338173,
-0.002854118123650551,
-0.05884615704417229,
-0.040811192244291306,
-0.030103644356131554,
0.03641020879149437,
-0.021948210895061493,
-0.006663862150162458,
-0.004613661207258701,
0.0720491111278534,
-0.01445065625011921,
-0.008166776038706303,
0.00016225440776906908,
-0.009556261822581291,
0.03482222557067871,
-0.003397151827812195,
0.008178118616342545,
0.04827471822500229,
0.027903150767087936,
0.027086474001407623,
0.007049515377730131,
-0.00968670379370451,
-0.030534667894244194,
0.007525911089032888,
0.025112835690379143,
-0.043283913284540176,
0.0203715693205595,
0.005260197911411524,
0.03752179816365242,
-0.031895797699689865,
-0.03713614493608475,
0.03209996595978737,
-0.009312393143773079,
-0.014382599852979183,
-0.022526690736413002,
-0.023638278245925903,
-0.06392771005630493,
-0.02842491678893566,
0.016015954315662384,
-0.013520550914108753,
0.026065627112984657,
-0.0021607927046716213,
0.01667383499443531,
0.03112449124455452,
0.03627409785985947,
-0.025385061278939247,
0.03543473407626152,
-0.0025662959087640047,
0.04194546863436699,
-0.04968122020363808,
-0.013384438119828701,
0.0009137998567894101,
-0.008756598457694054,
-0.005776292644441128,
-0.014927051961421967,
0.014042317867279053,
-0.002194821136072278,
0.022730858996510506,
-0.010270855389535427,
0.015176591463387012,
-0.005739428568631411,
-0.017365742474794388,
-0.013248325325548649,
0.014416627585887909,
-0.03162357211112976,
-0.04845620319247246,
0.02688230387866497,
-0.0019353557145223022,
-0.03690928965806961,
0.0036268425174057484,
0.00813841912895441,
0.007508896756917238,
0.029990216717123985,
-0.04968122020363808,
-0.02484061010181904,
-0.02971798926591873,
0.000003749530151253566,
-0.050770122557878494,
-0.03922320902347565,
0.0298994742333889,
-0.03579770028591156,
0.008093047887086868,
-0.00005183988469070755,
0.00034843492903746665,
0.009153594262897968,
-0.0018899848219007254,
0.007248013745993376,
0.01632220856845379,
0.018624786287546158,
0.05449054390192032,
-0.00812140479683876,
0.024432271718978882,
-0.002943442203104496,
0.01703680120408535,
-0.00155253813136369,
-0.04251260682940483,
-0.007355769630521536,
0.001785064348950982,
0.003521922044456005,
-0.021948210895061493,
0.006788632366806269,
-0.018851641565561295,
-0.018919697031378746,
0.002165046287700534,
0.012159422039985657,
-0.016333552077412605,
0.004026674199849367,
-0.013985604047775269,
0.03477685526013374,
-0.0022657131776213646,
-0.010826649144291878,
0.003272381843999028,
-0.03166894242167473,
0.003649527905508876,
-0.0035928143188357353,
-0.024001246318221092,
0.026292480528354645,
0.022469976916909218,
-0.035525474697351456,
-0.014870338141918182,
-0.024454956874251366,
-0.022923685610294342,
0.008711227215826511,
-0.021607927978038788,
0.031895797699689865,
-0.02479523979127407,
0.0022869808599352837,
-0.022435948252677917,
0.022481318563222885,
0.021335702389478683,
-0.03677317872643471,
0.00717995734885335,
-0.013066841289401054,
-0.008314231410622597,
0.015596273355185986,
0.004361285362392664,
-0.021539870649576187,
-0.008359602652490139,
0.010038328357040882,
0.007616652641445398,
-0.003482222557067871,
-0.02903742529451847,
-0.015051822178065777,
-0.0035247576888650656,
0.06692218780517578,
-0.006595805753022432,
-0.010344582609832287,
0.024023933336138725,
0.030126329511404037,
0.004111744929105043,
0.050225671380758286,
-0.011955252848565578,
-0.019350722432136536,
-0.0021026611793786287,
0.02713184431195259,
-0.01688934676349163,
-0.0032326821237802505,
0.007253685034811497,
-0.021970896050333977,
-0.040811192244291306,
0.03947275131940842,
0.0159932691603899,
-0.013452494516968727,
0.022367890924215317,
-0.07504359632730484,
-0.003663706360384822,
0.0051410989835858345,
0.019679661840200424,
-0.013917547650635242,
-0.0046108257956802845,
-0.039949145168066025,
0.007860521785914898,
0.028402231633663177,
0.034663427621126175,
0.017048144713044167,
0.0341416597366333,
-0.041242219507694244,
0.007140257395803928,
-0.017161572352051735,
-0.007730080280452967,
-0.0034368515480309725,
-0.030035587027668953,
-0.004693060647696257,
0.027948522940278053,
-0.012170764617621899,
-0.0028980711940675974,
-0.01592521369457245,
-0.002472718246281147,
-0.03684123232960701,
0.0010038329055532813,
-0.002664127154275775,
0.019169237464666367,
-0.017014116048812866,
0.014654825441539288,
-0.011671683751046658,
0.003445358481258154,
-0.021789411082863808,
0.07109632343053818,
0.03665975108742714,
-0.04126490280032158,
0.021619271486997604,
-0.015675673261284828,
-0.010809635743498802,
0.007077872287482023,
0.003848026040941477,
0.017127543687820435,
-0.023229939863085747,
0.008042005822062492,
-0.02976336143910885,
0.06751201301813126,
-0.0026924838311970234,
0.007191299926489592,
0.021301673725247383,
0.023706335574388504,
0.0008641753229312599,
0.011093203909695148,
-0.027880465611815453,
-0.028629086911678314,
0.024591069668531418,
0.04439550265669823,
0.0006936797290109098,
-0.04258066043257713,
-0.048138607293367386,
-0.00977744534611702,
0.007219656836241484,
0.030375869944691658,
0.024409586563706398,
0.0066468482837080956,
-0.026156367734074593,
0.049363624304533005,
-0.007843507453799248,
-0.019180580973625183,
-0.00857511442154646,
-0.009771774522960186,
-0.030716150999069214,
-0.016435636207461357,
0.011898539029061794,
-0.046595994383096695,
-0.03523056209087372,
0.05344701185822487,
0.008302888832986355,
0.008790627121925354,
-0.016049982979893684,
0.04791175201535225,
0.0011668847873806953,
-0.03316618502140045,
-0.01642429456114769,
0.016435636207461357,
-0.012851329520344734,
-0.027653610333800316,
-0.009981615468859673,
-0.033120814710855484,
-0.021018104627728462,
-0.016412951052188873,
0.005920912604779005,
-0.025997569784522057,
-0.0021466142497956753,
-0.015539559535682201,
0.010202798061072826,
0.02547580376267433,
-0.001464631874114275,
-0.027812408283352852,
-0.001777975121513009,
0.04085656628012657,
0.0318504273891449,
-0.04827471822500229,
0.06773886829614639,
-0.00778112281113863,
-0.02817537635564804,
-0.00536511791869998,
0.014257829636335373,
-0.0047838022001087666,
-0.01504047866910696,
0.014586769044399261,
0.001478810328990221,
0.01761528104543686,
-0.03223608061671257,
-0.012533732689917088,
0.010537409223616123,
0.02835686132311821,
-0.011977938003838062,
-0.028515659272670746,
-0.027222586795687675,
-0.0019311022479087114,
0.02504478022456169,
0.03051198273897171,
-0.03604724258184433,
0.017025459557771683,
-0.012397619895637035,
-0.026292480528354645,
0.0066978903487324715,
-0.012692530639469624,
0.009766102768480778,
0.02379707805812359,
0.003425508737564087,
-0.018851641565561295,
-0.002641441533342004,
-0.023955876007676125,
-0.03371063619852066,
-0.047095075249671936,
0.025679973885416985,
-0.014473341405391693,
-0.005719578824937344,
-0.022957714274525642,
-0.014496027491986752,
0.03856533020734787,
0.03130597248673439,
0.014745567925274372,
0.02102944813668728,
0.0034084946382790804,
-0.026179054751992226,
0.03284858912229538,
-0.022946372628211975,
0.00909120962023735,
0.024023933336138725,
-0.010792621411383152,
-0.018091676756739616,
-0.007832164876163006,
-0.020655136555433273,
0.010820978321135044,
-0.033007387071847916,
0.019033124670386314,
0.011059176176786423,
0.00262868101708591,
0.03947275131940842,
0.014881680719554424,
-0.016560407355427742,
-0.018488673493266106,
0.020802592858672142,
-0.01761528104543686,
0.0023876477498561144,
-0.020031286403536797,
0.01750185526907444,
-0.016401607543230057,
-0.02008800022304058,
0.05113309249281883,
-0.08792895078659058,
-0.020575737580657005,
-0.02719990164041519,
-0.002746362006291747,
-0.016163410618901253,
0.022730858996510506,
-0.0011633401736617088,
0.009176280349493027,
0.010520395822823048,
-0.038361161947250366,
0.018851641565561295,
-0.01088903471827507,
-0.016084011644124985,
0.02174404077231884,
0.001874388544820249,
-0.03153282776474953,
-0.032394878566265106,
-0.009873858653008938,
-0.024523012340068817,
0.03203190863132477,
0.02527163363993168,
0.00009960347233572975,
-0.018465988337993622,
0.048183977603912354,
-0.04108342155814171,
0.0015582095365971327,
-0.010582780465483665,
-0.018273161724209785,
-0.028492974117398262,
-0.017365742474794388,
0.0010534573812037706,
0.020428283140063286,
-0.020212769508361816,
0.022265806794166565,
0.003609828418120742,
-0.02810732088983059,
0.02651933580636978,
0.0035786358639597893,
0.0031277616508305073,
0.021823439747095108,
-0.02368365041911602,
0.03241756185889244,
0.0233660526573658,
0.024591069668531418,
-0.028220748528838158,
0.0036948989145457745,
0.000007847982487874106,
0.0021480321884155273,
0.004857530351728201,
-0.021437786519527435,
-0.03316618502140045,
-0.03155551478266716,
0.03262173384428024,
0.022912343963980675,
0.015755072236061096,
-0.02958187647163868,
-0.019577575847506523,
0.01448468491435051,
0.012715216726064682,
0.0022940700873732567,
0.008314231410622597,
-0.003434015903621912,
0.018091676756739616,
-0.0010371521348133683,
-0.008909725584089756,
0.008495715446770191,
-0.01977040246129036,
0.01631086692214012,
-0.050588641315698624,
0.010004300624132156,
-0.003144775750115514,
-0.0051269205287098885,
-0.05753039941191673,
0.029513821005821228,
0.006902060005813837,
-0.018034962937235832,
-0.024954037740826607,
0.0026400238275527954,
-0.01399694662541151,
0.006380293518304825,
-0.03033049777150154,
-0.024069303646683693,
-0.05303867161273956,
-0.0003711204044520855,
-0.024091988801956177,
-0.013668007217347622,
0.001629101694561541,
0.001484481617808342,
0.007406812161207199,
-0.023388739675283432,
0.03305275738239288,
-0.036569006741046906,
-0.013157583773136139,
0.0383838452398777,
0.017876164987683296,
-0.034595370292663574,
-0.03384675085544586,
-0.005960612092167139,
0.022628774866461754,
-0.026859618723392487,
0.026405908167362213,
-0.016594434157013893,
0.017706023529171944,
-0.021721355617046356,
0.037249572575092316,
-0.028674457222223282,
-0.001321429735980928,
-0.024885980412364006,
0.016843974590301514,
0.0027094981633126736,
0.034731484949588776,
0.00031050763209350407,
0.02189149707555771,
0.01796690747141838,
0.016594434157013893,
-0.00871689897030592,
0.015029136091470718,
-0.028266118839383125,
0.001390904071740806,
-0.007809479255229235,
0.03686391934752464,
0.042784832417964935,
-0.03296201676130295,
-0.042353808879852295,
-0.01196659542620182,
0.0057167429476976395,
-0.020326197147369385,
0.050407156348228455,
0.010883362963795662,
0.03105643391609192,
-0.007786794099956751,
0.04723118618130684,
0.016220124438405037,
-0.008762270212173462,
-0.02264011837542057,
0.0035275935661047697,
0.0061817956157028675,
0.0511784628033638,
0.030421240255236626,
0.018420616164803505,
-0.002451450563967228,
0.015346732921898365,
0.007769779767841101,
0.01470019668340683,
0.06120544672012329,
-0.0075996387749910355,
-0.04194546863436699,
-0.010293540544807911,
-0.03920052573084831,
-0.0026116669178009033,
0.01494973711669445,
0.006170453038066626,
0.031169861555099487,
0.05571556091308594,
-0.018034962937235832,
0.0042932284995913506,
-0.004897229839116335,
-0.014802281744778156,
0.012488361448049545,
0.03504908084869385,
-0.01494973711669445,
0.03806624934077263,
-0.054036833345890045,
-0.053537752479314804,
0.0013093780726194382,
0.007282041944563389,
0.007259356323629618,
-0.0011002462124451995,
0.023048456758260727,
0.025543861091136932,
0.003113583428785205,
-0.05762114003300667,
0.04158250242471695,
-0.02253803238272667,
-0.0050872210413217545,
0.029854103922843933,
0.004264872055500746,
-0.026610078290104866,
0.019940543919801712,
0.023910505697131157,
0.015085849910974503,
0.004948272369801998,
0.0012994532007724047,
0.029672618955373764,
-0.012771930545568466,
-0.0341416597366333,
-0.011660341173410416,
-0.019067153334617615,
-0.00752023933455348,
-0.011405128985643387,
-0.018953725695610046,
-0.005464367102831602,
0.023706335574388504,
0.045552462339401245,
0.039586178958415985,
-0.012159422039985657,
0.0020927363075315952,
0.047458041459321976,
-0.030375869944691658,
-0.0004760407900903374,
0.0025251784827560186,
0.00609105359762907,
0.06156841665506363,
-0.004491726867854595,
-0.008348260074853897,
0.017944222316145897,
0.027835095301270485,
-0.04022137075662613,
-0.05639612302184105,
0.07758437097072601,
-0.03702271729707718,
0.027653610333800316,
-0.02540774643421173,
0.03162357211112976,
0.00039203360211104155,
-0.02742675505578518,
0.009590290486812592,
0.00040514866122975945,
-0.008921068161725998,
-0.013293696567416191,
-0.016503693535923958,
-0.047095075249671936,
-0.012374933809041977,
-0.0029264281038194895,
0.036637064069509506,
0.02134704403579235,
-0.008512729778885841,
0.017921535298228264,
-0.012080023065209389,
0.022583404555916786,
-0.009391792118549347,
0.028447601944208145,
0.011382443830370903,
0.02418273128569126,
-0.018738213926553726,
-0.004897229839116335,
0.018500015139579773,
-0.028833255171775818,
0.035888444632291794,
-0.02059842459857464,
0.01919192261993885,
0.06406381726264954,
-0.03525324910879135,
-0.008563771843910217,
0.002562042325735092,
-0.0052743759006261826,
0.029536506161093712,
-0.02397856116294861,
-0.005322582554072142,
-0.023842448368668556,
-0.01279461570084095,
0.010526066645979881,
-0.003978467546403408,
0.018919697031378746,
-0.004222336690872908,
0.004069209564477205,
-0.0061364248394966125,
-0.023910505697131157,
0.019055809825658798,
-0.013758748769760132,
0.004775295499712229,
-0.01955489069223404,
-0.028561029583215714,
0.026678133755922318,
-0.010202798061072826,
0.013724721036851406,
-0.023161884397268295,
-0.00483484473079443,
0.011955252848565578,
0.015868499875068665,
-0.019486835226416588,
-0.01864747144281864,
-0.059027642011642456,
-0.007038172800093889,
-0.009062852710485458,
-0.01556224562227726,
0.011416472494602203,
-0.0426940880715847,
-0.039767660200595856,
-0.003507743589580059,
0.019781745970249176,
0.009612975642085075,
-0.00437546381726861,
-0.007230999413877726,
0.02217506431043148,
0.023229939863085747,
-0.015607615932822227,
-0.029128167778253555,
0.011093203909695148,
-0.03203190863132477,
0.00010793330147862434,
0.024704497307538986,
0.023842448368668556,
-0.020723193883895874,
-0.0246137548238039,
-0.05267570540308952,
-0.024205416440963745,
-0.016775919124484062,
-0.007440840359777212,
-0.004766788333654404,
-0.020360225811600685,
-0.004188308492302895,
0.006022997200489044,
0.006805646698921919,
0.002240191912278533,
-0.0029406065586954355,
-0.03425508737564087,
-0.04208158329129219,
0.0038933970499783754,
-0.00247980747371912,
-0.029513821005821228,
0.035026393830776215,
-0.00898345373570919,
-0.010367268696427345,
-0.009862516075372696,
-0.020348884165287018,
-0.0072366707026958466,
-0.007985292002558708,
0.021755384281277657,
-0.011450500227510929,
0.00122643425129354,
-0.02095004916191101,
-0.026904989033937454,
-0.015392104163765907,
-0.011223645880818367,
-0.02228849194943905,
0.009482534602284431,
-0.004775295499712229,
-0.008024991489946842,
0.004551276098936796,
0.012068679556250572,
0.0007209731847979128,
0.009760431945323944,
-0.01617475412786007,
0.012851329520344734,
-0.0025506995152682066,
-0.01728634163737297,
-0.012839986942708492,
0.036886606365442276,
-0.012976099736988544,
0.013702034950256348,
-0.011019475758075714,
0.003910411149263382,
0.019135208800435066,
-0.0000060092174862802494,
-0.008603471331298351,
0.0010520395589992404,
-0.0005841513047926128,
0.0021820603869855404,
-0.03303007036447525,
0.04230843484401703,
0.012216135859489441,
-0.01969100348651409,
0.022628774866461754,
0.041242219507694244,
0.014654825441539288,
-0.013804120011627674,
0.009125237353146076,
-0.013849491253495216,
-0.005322582554072142,
-0.004647689405828714,
0.03486759588122368,
0.034164346754550934,
-0.016583092510700226,
-0.01291938591748476,
-0.002444361336529255,
-0.026405908167362213,
0.013441151939332485,
0.010684865526854992,
0.035162508487701416,
0.024205416440963745,
-0.00125337322242558,
-0.025997569784522057,
0.007894550450146198,
-0.019135208800435066,
0.0026797233149409294,
0.034118976444005966,
0.015051822178065777,
0.004517247900366783,
0.032190706580877304,
-0.024273473769426346,
-0.003638185327872634,
0.01864747144281864,
-0.010423981584608555,
-0.01589118503034115,
0.000014233814908948261,
-0.0003051907115150243,
-0.007690380793064833,
0.001824763952754438,
-0.006011654622852802,
0.023343367502093315,
-0.0028073291759938,
0.02368365041911602,
-0.005158112850040197,
-0.012318219989538193,
0.00038246315671131015,
-0.01230687741190195,
0.009312393143773079,
0.004911408293992281,
0.012749244458973408,
-0.014972422271966934,
-0.021585242822766304,
0.033188868314027786,
0.011819139122962952,
-0.0016319373389706016,
0.015596273355185986,
-0.0034368515480309725,
0.04754878580570221,
-0.0046108257956802845,
0.00633492274209857,
-0.03314349800348282,
-0.004922750871628523,
-0.021551214158535004,
0.008268860168755054,
-0.0001393030834151432,
-0.012136736884713173,
0.029536506161093712,
-0.008393630385398865,
-0.025861456990242004,
0.001145617221482098,
-0.012363591231405735,
-0.018125705420970917,
0.00990221556276083,
0.024454956874251366,
-0.017955563962459564,
0.00001654888728808146,
0.0006263321847654879,
-0.002499657217413187,
0.010945748537778854,
-0.01491570845246315,
0.04196815565228462,
-0.005937926471233368,
-0.00182618189137429,
0.005971954669803381,
-0.021846124902367592,
-0.0017085009021684527,
-0.014904365874826908,
-0.01180779654532671,
-0.007350098341703415,
-0.010372939519584179,
-0.0027704653330147266,
0.059073012322187424,
0.012771930545568466,
0.016843974590301514,
0.026927674189209938,
-0.013928890228271484,
-0.009329407475888729,
0.019793089479207993,
0.03684123232960701,
0.006351936608552933,
0.0023479480296373367,
0.017411112785339355,
-0.00803066324442625,
-0.009987286292016506,
-0.0308749508112669,
0.0003018233401235193,
-0.042852889746427536,
-0.018999096006155014,
0.02792583592236042,
0.015789100900292397,
-0.0011392368469387293,
0.0009598797187209129,
0.015539559535682201,
-0.025294320657849312,
0.023547537624835968,
-0.00019885248912032694,
-0.02267414517700672,
0.014303200878202915,
-0.03144208714365959,
-0.019759060814976692,
0.0075939674861729145,
0.060797110199928284,
-0.007622324395924807,
-0.008677199482917786,
-0.011955252848565578,
-0.01919192261993885,
-0.0012065843911841512,
0.025248948484659195,
-0.018068991601467133,
0.011648998595774174,
-0.03069346584379673,
0.06057025492191315,
0.02368365041911602,
0.002549281809478998,
0.00014594921958632767,
0.019849803298711777,
0.010554423555731773,
-0.020099343731999397,
0.03992646187543869,
0.010378611274063587,
-0.013146240264177322,
0.03849727287888527,
-0.018931040540337563,
-0.030648095533251762,
0.0009272693423554301,
0.024817924946546555,
-0.048864543437957764,
-0.03432314470410347,
0.010401296429336071,
0.03296201676130295,
-0.03990377485752106,
0.030171699821949005,
-0.0008237668080255389,
-0.014813624322414398,
0.013225640170276165,
-0.01148452889174223,
-0.06710367649793625,
-0.037862081080675125,
-0.016843974590301514,
-0.00645969295874238,
0.01584581471979618,
-0.006488049868494272,
-0.041922781616449356,
0.03432314470410347,
0.00739546911790967,
0.0276762954890728,
-0.028651772066950798,
0.04317048564553261,
-0.010599794797599316,
-0.029740676283836365,
-0.013316381722688675,
0.0018573743291199207,
0.008801969699561596,
-0.015675673261284828,
-0.0320545956492424,
-0.015119878575205803,
0.004840516019612551,
0.03425508737564087,
-0.0017396934563294053,
0.008682871237397194,
0.015879841521382332,
0.004208158235996962,
0.024318844079971313,
-0.041605185717344284,
0.012987442314624786,
0.024863295257091522,
0.0028527001850306988,
0.00765635259449482,
-0.0090741952881217,
0.014235144481062889,
-0.029695304110646248,
0.014019631780683994,
-0.005756442900747061,
-0.028447601944208145,
0.009108223952353,
-0.007333084009587765,
0.03591112792491913,
-0.0005199939478188753,
0.020190084353089333,
0.013577264733612537,
0.03727225959300995,
-0.031169861555099487,
0.013736063614487648,
0.010350254364311695,
-0.00046150790876708925,
-0.0038111621979624033,
-0.0034170018043369055,
0.02799389325082302,
-0.003005827311426401,
0.04319316893815994,
-0.010140413418412209,
-0.025725344195961952,
-0.001572387875057757,
0.0014830637956038117,
-0.007525911089032888,
-0.0015341062098741531,
0.0009272693423554301,
0.010333240032196045,
-0.01291938591748476,
0.032508306205272675,
-0.01940743625164032,
-0.007690380793064833,
0.01563030108809471,
-0.04430475831031799,
-0.03910978138446808,
0.024500327184796333,
-0.009573276154696941,
-0.019396092742681503,
0.011365429498255253,
-0.017694681882858276,
-0.004514412023127079,
-0.00753725366666913,
-0.013236982747912407,
0.011637656018137932,
-0.019055809825658798,
-0.018409274518489838,
-0.0006224330863915384,
-0.0057252501137554646,
-0.007423826027661562,
0.009267021901905537,
-0.018409274518489838,
-0.039881087839603424,
0.011853167787194252,
0.012136736884713173,
0.019645633175969124,
0.00882465485483408,
-0.011853167787194252,
0.00012450433860067278,
-0.045915428549051285,
0.010560095310211182,
0.045370977371931076,
0.03827041760087013,
0.021834783256053925,
-0.02232252061367035,
0.024954037740826607,
0.013565922155976295,
0.002949113491922617,
-0.017547225579619408,
-0.020745879039168358,
0.005075877998024225,
0.0001852057466749102,
0.001532688271254301,
-0.016435636207461357,
0.014030974358320236,
0.027041101828217506,
0.037975508719682693,
-0.023082485422492027,
-0.01263581681996584,
0.027018416672945023,
-0.01864747144281864,
0.008002306334674358,
0.02713184431195259,
-0.004276214633136988,
-0.008563771843910217,
-0.035638902336359024,
0.010560095310211182,
-0.003992646001279354,
-0.031215231865644455,
0.016072668135166168,
0.026224425062537193,
-0.025543861091136932,
0.015834471210837364,
0.012930728495121002,
-0.011671683751046658,
-0.036206040531396866,
-0.0339374914765358,
-0.008887040428817272,
0.020530367270112038,
-0.015142563730478287,
0.002445779275149107,
0.02091602049767971,
0.004327257163822651,
-0.016197439283132553,
-0.0020530368201434612,
0.00048809245345182717,
0.005288554355502129,
-0.023729020729660988,
-0.05925449728965759,
-0.009771774522960186,
-0.0308068934828043,
-0.030489297583699226,
0.007299055811017752,
0.014201115816831589,
0.012624474242329597,
0.01839793100953102,
-0.005620329640805721,
0.0002555662067607045,
-0.007900221273303032,
-0.01929400861263275,
0.0036608707159757614,
0.024500327184796333,
-0.018420616164803505,
-0.01482496690005064,
0.019486835226416588,
0.004228007979691029,
0.00488872267305851,
0.008478701114654541,
0.00875092763453722,
-0.024817924946546555,
0.0018786420114338398,
-0.011773768812417984,
-0.00752023933455348,
-0.013475180603563786,
0.004296064376831055,
0.10516992211341858,
-0.025634601712226868,
-0.019316693767905235,
0.0022742203436791897,
-0.024523012340068817,
-0.010900377295911312,
0.015267333947122097,
-0.016254153102636337,
0.009159266017377377,
0.0014873173786327243,
0.015301361680030823,
0.018205104395747185,
0.000051175273256376386,
0.06778424233198166,
0.004772459622472525,
-0.018409274518489838,
-0.014371257275342941,
0.029423078522086143,
-0.02509015053510666,
0.0023266803473234177,
-0.015868499875068665,
0.005932255182415247,
-0.011909881606698036,
0.03729494288563728,
-0.014019631780683994,
-0.0138721764087677,
0.007185628637671471,
-0.03432314470410347,
-0.030035587027668953,
-0.012295534834265709,
0.00013318863057065755,
-0.0255211740732193,
0.01099679060280323,
-0.02318456955254078,
0.03166894242167473,
0.009647004306316376,
-0.014427971094846725,
-0.02738138474524021,
-0.021154217422008514,
0.0424218624830246,
0.0008528325706720352,
-0.017082173377275467,
0.01193256676197052,
-0.0011725561926141381,
0.006953102070838213,
0.010832320898771286,
-0.023660965263843536,
0.008818984031677246,
0.03548010438680649,
-0.045484405010938644,
0.02910548262298107,
0.004392477683722973,
0.007321741431951523,
0.014155744574964046,
-0.012284192256629467,
-0.008943754248321056,
-0.004812159109860659,
0.013032813556492329,
0.010900377295911312,
0.0015823128633201122,
-0.002820089692249894,
0.006771618500351906,
0.009301050566136837,
-0.042217694222927094,
0.03661437705159187
] | 2024-07-04 | 252 | 38961036 | [
"MM cells",
"MM treatment",
"malignant plasma cells",
"MM management",
"MM",
"myeloma cells",
"plasma cells",
"targeted drugs",
"cell adhesion molecules",
"various signaling pathways",
"chimeric antigen receptor T cells",
"non-targeted drugs",
"combined targeted therapies",
"targeted therapy",
"immunomodulatory drugs",
"drug resistance",
"pathways",
"approved drugs",
"potential treatments",
"osteolytic bone lesions",
"treatment",
"proteasome inhibitors",
"many inhibitors",
"histone deacetylase inhibitors",
"emerging theoretical knowledge",
"bispecific antibodies",
"monoclonal antibodies",
"bispecific T-cell engagers",
"Multiple myeloma",
"further insights"
] | [
"Immunotherapies",
"Multiple myeloma",
"Signaling pathways",
"Targeted therapy"
] | 0 | 10.1186/s43556-024-00188-w
10.1016/j.semcdb.2020.10.006
10.1158/1078-0432.Ccr-20-3600
10.1001/jama.2022.0003
10.1182/blood.2023020284
10.3322/caac.21492
10.1001/jamaoncol.2018.2128
10.1053/j.seminoncol.2016.11.004
10.1002/hon.2586
10.1038/s41408-022-00719-0
10.1038/s41467-021-22804-x
10.3322/canjclin.16.4.142
10.1182/blood-2007-10-078022
10.12890/2020_002140
10.1038/s41375-020-0921-y
10.1186/s12943-021-01380-0
10.1038/s41392-021-00746-6
10.1096/fj.202200354
10.1038/s41388-022-02227-8
10.1016/j.cyto.2022.155851
10.1007/s10238-023-00992-8
10.3389/fonc.2022.999939
10.3390/ijms23063112
10.3389/fimmu.2022.909880
10.1002/mco2.146
10.1016/j.canlet.2017.11.020
10.1016/j.phymed.2021.153574
10.1371/journal.pone.0265958
10.1016/j.freeradbiomed.2023.04.003
10.1038/s41375-019-0404-1
10.1016/j.lfs.2020.117503
10.1186/s13046-021-01909-7
10.1016/j.critrevonc.2023.104040
10.1182/blood.2020008787
10.1200/jco.22.02665
10.3324/haematol.2022.282624
10.1007/s40265-017-0833-y
10.1038/s41375-019-0620-8
10.1016/s2352-3026(22)00290-3
10.1038/s41467-023-40385-9
10.1080/14740338.2018.1513487
10.1146/annurev-pharmtox-010919-023603
10.1016/s1470-2045(22)00738-0
10.1200/jco.23.01696
10.1007/s40265-015-0388-8
10.1186/s40164-021-00213-6
10.1056/NEJMoa1903455
10.1007/s40265-019-01188-9
10.1080/14656566.2024.2333376
10.1007/s00277-020-04378-8
10.1007/s00520-014-2552-1
10.1016/j.soncn.2017.05.008
10.1016/j.blre.2016.10.001
10.1016/j.blre.2018.11.003
10.1007/s00253-019-10257-8
10.1038/s41392-021-00791-1
10.1038/s41392-021-00762-6
10.1182/bloodadvances.2021005327
10.1016/s1470-2045(11)70028-6
10.1136/jim-2018-000780
10.1182/blood-2014-03-559963
10.1038/s41417-021-00309-5
10.1186/s12943-023-01827-6
10.1042/bst20110609
10.1074/jbc.M600482200
10.1111/j.1365-2443.2008.01218.x
10.1074/jbc.M104493200
10.1081/rrs-120034229
10.1002/stem.521
10.1016/s0960-9822(00)00177-9
10.1038/370527a0
10.1074/jbc.M110.159046
10.1111/bjh.12039
10.18632/oncotarget.8982
10.1002/hon.3208
10.1038/s41392-023-01705-z
10.1016/j.gendis.2022.05.006
10.1182/blood.v97.3.729
10.1200/jco.2014.59.1503
10.1038/oncsis.2017.36
10.1038/s41375-021-01475-z
10.1038/s41467-022-33142-x
10.1002/cam4.6103
10.1182/blood.V88.7.2699.bloodjournal8872699
10.1182/blood-2004-03-0833
10.1038/s41467-022-31430-0
10.1016/j.jtbi.2023.111652
10.1182/blood.2020010572
10.1182/blood-2007-03-081240
10.1158/1078-0432.Ccr-15-1076
10.1016/s1470-2045(20)30464-2
10.1182/blood.2022017789
10.1038/s41591-023-02321-8
10.1016/s0002-9440(10)64278-2
10.5045/br.2017.52.4.293
10.3390/cells11060941
10.1038/s41577-023-00856-y
10.1182/blood-2016-10-745059
10.1016/j.critrevonc.2016.07.006
10.1155/2017/1852517
10.1007/s40265-014-0249-x
10.1038/bcj.2016.4
10.1002/ijc.26152
10.1182/blood.2019004332
10.1002/hon.3066
10.1002/med.21574
10.1016/j.vph.2005.08.021
10.1159/000087907
10.1016/j.ccr.2009.02.015
10.3892/ol.2020.11678
10.7150/ijbs.45999
10.3892/or.2021.7934
10.2147/ott.S270636
10.1016/j.cyto.2021.155495
10.3390/jcm12134440
10.1074/jbc.M110.180208
10.1038/leu.2013.174
10.3892/ol.2018.8006
10.1128/mcb.00832-15
10.1126/science.1156037
10.1128/mcb.00550-10
10.1038/ijos.2015.7
10.1016/j.bbrc.2016.07.076
10.1016/j.it.2022.07.004
10.1002/jcp.30759
10.3390/biomedicines10112767
10.1182/blood.V87.3.1104.bloodjournal8731104
10.1182/blood-2003-06-1984
10.3390/ijms24031823
10.1182/blood-2006-07-034884
10.1016/j.ccr.2007.07.004
10.1016/j.ccr.2007.07.003
10.1038/s41467-024-46728-4
10.1158/1078-0432.Ccr-16-2735
10.1182/blood-2009-01-199604
10.1002/14651858.CD010816.pub2
10.1016/j.leukres.2013.10.018
10.1074/jbc.M115.663963
10.1016/j.tranon.2023.101765
10.1016/j.jep.2021.114791
10.1111/jfbc.13703
10.1016/j.apsb.2022.12.001
10.1158/1078-0432.Ccr-12-0779
10.1158/1078-0432.Ccr-14-1813
10.1080/19420862.2015.1007813
10.1056/NEJMoa1606038
10.1016/s1470-2045(21)00466-6
10.1056/NEJMoa2312054
10.1200/jco.22.00940
10.1016/s2352-3026(22)00103-x
10.1200/jco.21.02815
10.1002/hon.3031
10.1158/1078-0432.Ccr-14-0695
10.1182/blood.V124.21.3474.3474
10.1038/leu.2015.240
10.1038/s41375-020-0857-2
10.1038/s41408-023-00797-8
10.1016/j.semcancer.2022.03.020
10.1158/1078-0432.Ccr-22-1110
10.1038/s41577-023-00867-9
10.1126/sciimmunol.add8005
10.1200/jco.2015.65.9789
10.1111/bjh.15888
10.1158/1078-0432.Ccr-15-0200
10.1182/blood-2017-03-775122
10.1111/bjh.15946
10.1016/s2352-3026(19)30109-7
10.1182/blood.V130.Suppl_1.1858.1858
10.1182/blood-2018-99-114960
10.1038/s41375-021-01301-6
10.1007/s40265-020-01404-x
10.1182/blood-2020-139332
10.1002/cncr.34987
10.1158/1535-7163.Mct-20-0287
10.1158/1078-0432.Ccr-08-2867
10.1182/blood.V118.21.305.305
10.1016/j.clml.2019.02.006
10.1016/s2352-3026(21)00208-8
10.1038/s41408-020-00378-z
10.1182/blood-2020-136928
10.1182/blood-2022-156387
10.1038/s41408-019-0178-8
10.1016/S2152-2650(21)02352-1
10.1007/s40265-022-01793-1
10.1007/s40265-023-01954-w
10.1007/s40265-023-01945-x
10.1182/blood-2022-157547
10.1182/blood-2023-179356
10.1182/blood-2023-178948
10.1056/NEJMoa2203478
10.1038/s41591-023-02528-9
10.1200/JCO.2023.41.16_suppl.8006
10.1126/scitranslmed.aau7746
10.1038/s41571-023-00735-4
10.1182/bloodadvances.2020003805
10.1056/NEJMoa2204591
10.1158/1078-0432.Ccr-18-2752
10.3324/haematol.2019.242453
10.1186/s13045-021-01084-4
10.1182/blood-2022-157525
10.1182/blood-2021-147983
10.1182/blood-2018-99-109769
10.1200/jco.19.02657
10.1182/blood-2020-134063
10.1038/d41573-021-00063-1
10.1038/d41573-022-00048-8
10.1056/NEJMoa2209900
10.1186/s13045-023-01461-1
10.1016/s2352-3026(22)00372-6
10.1200/jco.21.01676
10.1158/2643-3230.Bcd-22-0074
10.1186/s13045-021-01170-7
10.1186/s13046-021-02214-z
10.1002/cam4.5818
10.1158/1078-0432.Ccr-23-0132
10.1038/s41467-020-16160-5
10.1038/s41375-022-01559-4
10.1038/s41375-023-02065-x
10.1158/2326-6066.Cir-18-0307
10.1016/s2352-3026(22)00378-7
10.1056/NEJMoa2024850
10.1200/jco.22.01365
10.1016/s0140-6736(21)00933-8
10.1200/jco.22.00842
10.1200/JCO.2023.41.16_suppl.8025
10.1182/blood-2021-152688
10.1016/j.ymthe.2023.12.018
10.3324/haematol.2022.280629
10.1200/JCO.2020.38.15_suppl.8504
10.1038/s41591-022-02182-7
10.1200/JCO.2023.41.16_suppl.8005
10.1182/blood-2021-153204
10.1182/blood-2022-162395
10.1182/blood-2023-181857
10.1200/jco.22.01824
10.1038/s41408-021-00507-2
10.1200/JCO.2021.39.15_suppl.8014
10.1182/blood-2023-174841
10.1158/2643-3230.Bcd-20-0020
10.1080/2162402x.2020.1743036
10.1182/blood.2020009759
10.1016/j.canlet.2024.216660
10.3389/fimmu.2018.01869
10.1186/s12943-020-01238-x
10.1016/j.canlet.2019.11.033
10.3389/fimmu.2020.611163
10.1016/j.ebiom.2020.102975
10.1186/s13045-020-00998-9
10.1186/s13045-021-01083-5
10.1038/leu.2013.279
10.1016/j.molonc.2013.12.001
10.1038/s41408-021-00537-w
10.1186/s40164-023-00461-8
10.1126/scitranslmed.aaz3339
10.1186/s13045-023-01408-6 | [
"Lu",
"Yang",
"Li",
"Niu",
"Tong"
] | [
"Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.",
"College of Veterinary Medicine, Shaanxi Center of Stem Cells Engineering and Technology, Northwest A&F University, Yangling, 712100, China.",
"Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.",
"Department of Hematology, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. [email protected].",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. [email protected].\nFrontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, 610212, China. [email protected]."
] | [
"38961036",
"33158730",
"33771856",
"35103762",
"37471603",
"30207593",
"29800065",
"28061985",
"31187526",
"36064707",
"33963182",
"33805803",
"4957754",
"18332230",
"33585332",
"28318212",
"32651540",
"34885058",
"34090465",
"34620840",
"35628498",
"35579877",
"35190641",
"32679860",
"35272075",
"38058269",
"36639599",
"36072809",
"35328533",
"35874665",
"35665368",
"29174802",
"34006448",
"35503759",
"37044150",
"30770859",
"32142767",
"33757580",
"34650674",
"35401182",
"37244325",
"33763699",
"36940404",
"37608773",
"29110190",
"31719682",
"36209764",
"37596276",
"30118610",
"31479618",
"36642080",
"37753960",
"25837990",
"33663586",
"31433920",
"31429063",
"38503547",
"33388856",
"25646616",
"28729122",
"27773462",
"30501907",
"31832711",
"34824210",
"34980884",
"35328342",
"34550328",
"21345726",
"37190302",
"29997148",
"25075128",
"33448321",
"33707625",
"37596643",
"22260680",
"16687399",
"18691227",
"11445578",
"15344880",
"20857497",
"7820549",
"8052307",
"21071439",
"22985491",
"27129151",
"32517267",
"37452600",
"38105263",
"37013062",
"11157491",
"26282654",
"28504689",
"35082402",
"36115844",
"37212518",
"8839865",
"15339850",
"35768438",
"37952610",
"34077955",
"17510321",
"26446942",
"33128873",
"36608320",
"37059834",
"12707028",
"29333406",
"35326392",
"37069261",
"28151428",
"27497026",
"29089667",
"38305581",
"24958337",
"26871714",
"21520044",
"32844992",
"35946431",
"30912203",
"16271517",
"16129950",
"19345327",
"32724371",
"32549754",
"33469678",
"33654408",
"33765653",
"37445475",
"21189262",
"23760401",
"29552217",
"26552705",
"18451303",
"20974802",
"26047580",
"27450807",
"35965153",
"35561232",
"32781681",
"36359286",
"8562936",
"15070697",
"36768145",
"17138824",
"17692804",
"17692805",
"38514625",
"28490465",
"19436050",
"27096326",
"24239172",
"25979341",
"37619524",
"34737112",
"33742464",
"36970199",
"22806876",
"25398450",
"25760767",
"27557302",
"34655533",
"38084760",
"36599114",
"35550060",
"35960908",
"35608183",
"24987056",
"26338273",
"31779273",
"32409691",
"33906862",
"37156782",
"35341912",
"35925043",
"37185300",
"36867679",
"27269947",
"30937889",
"25979485",
"28461396",
"31090915",
"31327689",
"34290359",
"32936437",
"37622738",
"33298585",
"19509164",
"30930134",
"34529955",
"33149123",
"0",
"30718503",
"38001595",
"36352205",
"37924427",
"37792138",
"35661166",
"37582952",
"30918115",
"36725915",
"33890981",
"36507686",
"30918018",
"32675220",
"33941237",
"31895611",
"33790473",
"35277677",
"36170501",
"37277826",
"36725117",
"35333600",
"36413381",
"34627333",
"34980210",
"37039305",
"37527004",
"32385241",
"35422095",
"37848634",
"30396908",
"36764323",
"33626253",
"36623248",
"34175021",
"35658469",
"38155568",
"35443566",
"36690811",
"0",
"36881785",
"34145225",
"33981079",
"0",
"33089218",
"32426176",
"33624009",
"38266806",
"30150991",
"32762681",
"31790761",
"33488617",
"32853984",
"33287875",
"33933160",
"24067492",
"24388357",
"34392311",
"38012722",
"33287413",
"32727914",
"36850001"
] | [] | 4.75807 | 6.40952 |
38960662 | 771 | [Challenges and strategies for improving efficacy in CAR-T therapy]. | CAR-T cell therapy targeting CD19 and BCMA for relapsed or refractory hematopoietic tumors has been adopted in routine practice and has shown dramatic results. However, half of patients who achieve remission with CAR-T therapy eventually relapse, and thus efforts to improve the efficacy of CAR-T therapy are gaining momentum. Notably, studies have described innovative technologies that enable control of cell kinetics after infusion, which is not possible with conventional CAR-T therapies. In this article, we review the challenges of CAR-T cell therapy and the development of new technologies. | [
0.027607044205069542,
0.03597492352128029,
0.06856560707092285,
0.026679854840040207,
-0.021962782368063927,
-0.013061771169304848,
-0.006513500586152077,
0.030087273567914963,
0.04021681100130081,
-0.00806074682623148,
0.021360110491514206,
-0.018451055511832237,
-0.04661441221833229,
0.011555089615285397,
0.02656395547091961,
-0.007788385264575481,
0.012065042741596699,
-0.02052563987672329,
0.01543769147247076,
0.042442064732313156,
-0.00042339201900176704,
0.011630423367023468,
0.016179442405700684,
0.014232346788048744,
-0.0170139130204916,
0.005380591843277216,
0.00037232422619126737,
0.014904558658599854,
-0.02969321794807911,
-0.028093818575143814,
0.031802572309970856,
-0.01944778300821781,
-0.03606764227151871,
-0.04390238597989082,
-0.0037261396646499634,
0.0440414622426033,
0.05349878966808319,
0.006067290902137756,
-0.0076956660486757755,
-0.028696490451693535,
0.02264658361673355,
0.024361882358789444,
0.01773248426616192,
0.09763296693563461,
-0.041213538497686386,
-0.022345248609781265,
-0.014336654916405678,
-0.05507500842213631,
-0.0038912950549274683,
0.016735756769776344,
-0.035604044795036316,
0.016955964267253876,
-0.04640579596161842,
0.003758011618629098,
-0.04721708595752716,
0.033726487308740616,
-0.01770930364727974,
0.009127013385295868,
0.020177943632006645,
0.007127763237804174,
0.011810066178441048,
-0.01201868336647749,
0.005366104654967785,
-0.021673036739230156,
-0.0505317859351635,
0.03414372354745865,
-0.03472321853041649,
-0.02772294171154499,
0.010778568685054779,
0.022217759862542152,
-0.0163880605250597,
0.014035318978130817,
-0.016156263649463654,
-0.004502660129219294,
0.03275294229388237,
-0.02211344987154007,
-0.0075971526093780994,
0.03150123730301857,
0.029832296073436737,
0.0011778194457292557,
0.03289201855659485,
-0.033123817294836044,
0.009944099001586437,
-0.03850151225924492,
-0.01634170114994049,
-0.004769227001816034,
0.01264453586190939,
-0.033100638538599014,
-0.012748844921588898,
-0.0004136130737606436,
-0.023226076737046242,
0.02050246112048626,
-0.041213538497686386,
0.05799565464258194,
-0.012864743359386921,
-0.002136880299076438,
-0.013351517729461193,
-0.05131989344954491,
0.03581266477704048,
0.04965095594525337,
0.05595583841204643,
0.01663144677877426,
-0.006501910742372274,
0.014649581164121628,
0.06249251961708069,
-0.026378517970442772,
-0.04965095594525337,
-0.008889421820640564,
0.03917372226715088,
-0.011114674620330334,
0.03323971480131149,
-0.048770125955343246,
-0.012377968989312649,
0.04137579724192619,
-0.010332359001040459,
-0.07626127451658249,
-0.013954189606010914,
-0.012934282422065735,
-0.02264658361673355,
0.029368702322244644,
-0.023782391101121902,
0.06671122461557388,
0.02389828860759735,
-0.0235853623598814,
-0.004024578258395195,
-0.004198426380753517,
0.07310882955789566,
-0.01612149365246296,
-0.04142215475440025,
-0.06100901588797569,
0.03736570477485657,
-0.005227026529610157,
0.018995778635144234,
-0.03532588854432106,
-0.0732942670583725,
0.010019432753324509,
-0.050717223435640335,
0.003723242087289691,
-0.03298473730683327,
0.0003154614823870361,
0.019262345507740974,
-0.011699962429702282,
-0.024083726108074188,
0.008443212136626244,
-0.01922757551074028,
-0.04668395221233368,
0.029994554817676544,
0.007985413074493408,
-0.005951392464339733,
0.03173303231596947,
-0.02579902485013008,
0.06351242959499359,
0.02909054607152939,
-0.008976345881819725,
0.0001156269499915652,
-0.020803796127438545,
-0.011323291808366776,
0.07885739952325821,
-0.04784293845295906,
-0.043137453496456146,
-0.005939802620559931,
-0.014359834603965282,
-0.029438240453600883,
-0.04325335472822189,
0.014394604600965977,
-0.017744073644280434,
-0.011688373051583767,
0.0477965772151947,
-0.04144533351063728,
0.0005450855242088437,
-0.00855331588536501,
-0.06596947461366653,
-0.0670357421040535,
-0.016712576150894165,
-0.018451055511832237,
0.021024003624916077,
0.009196553379297256,
0.023226076737046242,
-0.029438240453600883,
-0.02848787233233452,
0.012760434299707413,
0.011190008372068405,
0.008663419634103775,
-0.022275708615779877,
-0.03349469229578972,
-0.0011372548760846257,
-0.01643441990017891,
0.025590408593416214,
-0.03836243227124214,
-0.008831472136080265,
-0.00011988259939244017,
-0.03198800981044769,
0.010755388997495174,
0.002942375373095274,
-0.0027975020930171013,
0.009005320258438587,
0.052061647176742554,
0.01389624085277319,
-0.04596538096666336,
-0.01985342800617218,
0.036925289779901505,
-0.0013668789761140943,
-0.010627900250256062,
-0.00045381541713140905,
-0.041352614760398865,
0.012482278048992157,
0.004412838723510504,
0.015901286154985428,
-0.0008402647799812257,
-0.00009280941594624892,
0.020537229254841805,
-0.005166179500520229,
-0.028719669207930565,
0.05039270594716072,
-0.028256075456738472,
-0.0024309728760272264,
-0.008101311512291431,
0.03196483105421066,
0.007226277142763138,
0.03161713480949402,
-0.006988684646785259,
-0.014672760851681232,
0.011618833057582378,
0.013328338041901588,
0.010958211496472359,
0.007823154330253601,
0.013235618360340595,
-0.01735001802444458,
-0.016040364280343056,
-0.018346747383475304,
0.01090026181191206,
-0.0024816785007715225,
0.02264658361673355,
-0.03326289355754852,
-0.003149544121697545,
-0.021870063617825508,
0.013548544608056545,
0.01420916710048914,
0.047518420964479446,
-0.011056724935770035,
0.01149134524166584,
0.020757436752319336,
0.021545547991991043,
-0.03228934481739998,
-0.035604044795036316,
0.0043809665367007256,
-0.01672416552901268,
-0.040726762264966965,
0.04276657849550247,
-0.016515549272298813,
0.02461685985326767,
0.005980367306619883,
-0.022391607984900475,
0.003986911382526159,
0.03532588854432106,
0.01260976679623127,
0.03884920850396156,
-0.02658713608980179,
0.004276657942682505,
-0.023457873612642288,
-0.010036817751824856,
0.00234984396956861,
-0.04369376599788666,
-0.03643851727247238,
-0.06049906462430954,
0.029925014823675156,
-0.013108130544424057,
0.021788934245705605,
0.06573767960071564,
-0.014035318978130817,
0.021139902994036674,
0.013421056792140007,
0.01291110273450613,
-0.025590408593416214,
-0.03282247856259346,
0.016619857400655746,
-0.008611264638602734,
0.014753890223801136,
0.007544998079538345,
0.03866376727819443,
0.02360854297876358,
0.008280954323709011,
-0.0014545272570103407,
-0.04533952847123146,
-0.005256000906229019,
-0.008454802446067333,
-0.004207118880003691,
0.017176169902086258,
0.0017964281141757965,
-0.04728662222623825,
0.0056500560604035854,
-0.010709029622375965,
-0.026795754209160805,
-0.05345242843031883,
0.01036133337765932,
-0.004149169661104679,
-0.0017848382703959942,
-0.0065888348035514355,
-0.0373888835310936,
0.021719396114349365,
-0.06040634587407112,
0.022298889234662056,
-0.03720344603061676,
-0.031825751066207886,
0.01980706863105297,
0.018149718642234802,
-0.018138129264116287,
-0.028186537325382233,
0.014730710536241531,
0.04744888097047806,
0.013131310231983662,
-0.005997751839458942,
0.03094492293894291,
0.00771884573623538,
-0.020908106118440628,
0.015959234908223152,
0.0015153740532696247,
-0.08794385194778442,
0.01036133337765932,
-0.048306532204151154,
-0.03154759481549263,
-0.02593810483813286,
-0.03606764227151871,
0.054611414670944214,
0.006722118239849806,
-0.038176994770765305,
0.007527613081037998,
-0.017628176137804985,
0.03829289227724075,
-0.02848787233233452,
0.00031709129689261317,
-0.03847832977771759,
0.042581140995025635,
-0.03333243355154991,
0.014510503038764,
-0.015970826148986816,
-0.02115149237215519,
-0.0653204470872879,
0.025126812979578972,
-0.007678281515836716,
0.006542475428432226,
0.023284025490283966,
-0.03866376727819443,
0.052664317190647125,
0.0034190083388239145,
-0.0033118021674454212,
0.0038681153673678637,
0.005441438872367144,
-0.024477781727910042,
0.03541860729455948,
0.005780442152172327,
0.005293667782098055,
0.027444785460829735,
0.00710458355024457,
-0.010088971816003323,
0.0605454221367836,
-0.02658713608980179,
0.005792031995952129,
0.0027917071711272,
-0.0039115771651268005,
0.00462725106626749,
0.02774612233042717,
-0.019389834254980087,
0.038084276020526886,
0.043160635977983475,
0.08414237201213837,
-0.023596951737999916,
0.004221606068313122,
-0.04299837723374367,
-0.024222804233431816,
-0.0011321842903271317,
-0.010940826497972012,
-0.005537054967135191,
0.02309858798980713,
-0.022194579243659973,
0.03161713480949402,
0.047703858464956284,
0.007672486361116171,
0.019239164888858795,
0.03082902356982231,
0.015066816471517086,
-0.05442597717046738,
-0.021186262369155884,
-0.032382067292928696,
-0.006310678087174892,
0.04214072600007057,
0.013015411794185638,
-0.003824653336778283,
-0.07287703454494476,
0.030133632943034172,
-0.003027850529178977,
-0.01605195365846157,
-0.004097015131264925,
-0.009694917127490044,
0.014684351161122322,
0.06425417959690094,
-0.028626950457692146,
0.0930897444486618,
0.03861740976572037,
0.028673309832811356,
0.01857854425907135,
-0.028557412326335907,
-0.040726762264966965,
-0.04969731345772743,
-0.0012133133132010698,
-0.012308429926633835,
0.045223627239465714,
0.006374422460794449,
0.03319335728883743,
0.01167098805308342,
-0.012343199923634529,
0.025080453604459763,
0.034398701041936874,
-0.005418259184807539,
0.015472461469471455,
-0.01835833676159382,
-0.04221026599407196,
0.04721708595752716,
-0.031037641689181328,
0.050624504685401917,
0.03291519731283188,
-0.00027055077953264117,
-0.00004185478246654384,
-0.03486229479312897,
-0.01540292240679264,
0.014035318978130817,
0.03419008478522301,
0.018636493012309074,
-0.026054002344608307,
-0.045107729732990265,
-0.01327038835734129,
0.054518695920705795,
0.011862220242619514,
-0.006530885584652424,
0.0050618709065020084,
0.06499592959880829,
-0.028232896700501442,
0.01913485676050186,
-0.037458423525094986,
0.005351617466658354,
-0.007255251519382,
0.0004085425171069801,
0.012470687739551067,
-0.008472186513245106,
0.03789883852005005,
0.00596877746284008,
-0.004838766064494848,
0.02103559300303459,
-0.02069948799908161,
-0.019378243014216423,
0.0008837267523631454,
-0.018706033006310463,
0.011647808365523815,
0.010709029622375965,
-0.04965095594525337,
-0.0008945922018028796,
0.006391806993633509,
-0.08655306696891785,
0.009723891504108906,
0.050253625959157944,
0.012714074924588203,
-0.054565053433179855,
0.037551142275333405,
-0.0371570885181427,
-0.007736230734735727,
0.05910827964544296,
0.062168002128601074,
-0.013479005545377731,
-0.006982889957726002,
-0.039961833506822586,
0.018659671768546104,
0.02175416424870491,
-0.03017999231815338,
-0.003108979668468237,
-0.00030296616023406386,
0.05294247344136238,
0.03544178977608681,
0.010778568685054779,
0.009080654010176659,
-0.00005437273648567498,
-0.01665462739765644,
-0.007000274490565062,
-0.008402647450566292,
0.005067665595561266,
0.03279929980635643,
0.008703984320163727,
-0.018184488639235497,
-0.0031640315428376198,
-0.0505317859351635,
0.017720894888043404,
0.023179717361927032,
0.0018862495198845863,
0.02050246112048626,
-0.009874559938907623,
-0.024222804233431816,
-0.041978467255830765,
-0.03266022354364395,
0.009080654010176659,
-0.019841838628053665,
0.004479480441659689,
-0.004036168102174997,
0.015553590841591358,
0.014580042101442814,
0.03203437104821205,
0.05488957092165947,
0.04914100095629692,
0.015368152409791946,
0.050624504685401917,
0.016886424273252487,
0.03852469101548195,
-0.040031373500823975,
-0.00021477456903085113,
0.04744888097047806,
-0.020224303007125854,
-0.040587686002254486,
-0.0068322219885885715,
-0.046359434723854065,
-0.03578948229551315,
-0.006652579177170992,
0.005363207310438156,
-0.01477706991136074,
0.0068669915199279785,
-0.006948120426386595,
0.006513500586152077,
0.020490869879722595,
-0.02707391045987606,
-0.018126539885997772,
-0.0031524416990578175,
-0.0342596210539341,
-0.007765205577015877,
0.015773797407746315,
-0.02043292112648487,
-0.009277681820094585,
0.013629673980176449,
0.003998501226305962,
-0.041862569749355316,
-0.04526998847723007,
0.036229897290468216,
-0.05294247344136238,
-0.03282247856259346,
0.010755388997495174,
-0.03660077229142189,
0.008025976829230785,
0.0038362431805580854,
-0.020328612998127937,
0.024315522983670235,
-0.013757162727415562,
-0.023759210482239723,
-0.011288522742688656,
0.010164306499063969,
0.02117467112839222,
-0.029878655448555946,
0.004676508251577616,
-0.012354789301753044,
0.03884920850396156,
-0.04174667224287987,
-0.0010104908142238855,
-0.03261386230587959,
0.007852129638195038,
-0.02892828732728958,
-0.003407418495044112,
-0.010025227442383766,
0.007498638704419136,
-0.033772848546504974,
-0.019482553005218506,
0.05090266093611717,
-0.000856925209518522,
-0.033796027302742004,
-0.03671667352318764,
0.018682852387428284,
0.0007815911085344851,
0.027352066710591316,
0.011010365560650826,
-0.057068463414907455,
0.022519094869494438,
0.010210665874183178,
-0.00801438745111227,
0.004702585283666849,
-0.012053453363478184,
0.021429648622870445,
-0.02336515486240387,
-0.031107181683182716,
-0.03829289227724075,
0.05317427217960358,
-0.009184963069856167,
0.024106906726956367,
-0.050160907208919525,
-0.0014371424913406372,
-0.0012835768284276128,
0.0038768078666180372,
0.04605809971690178,
-0.00031473711715079844,
0.029994554817676544,
0.03031907044351101,
-0.03831607475876808,
0.045849479734897614,
0.015936056151986122,
-0.0026729111559689045,
-0.010726414620876312,
0.005397976841777563,
-0.008130285888910294,
-0.022009141743183136,
0.0009989009704440832,
-0.04839925095438957,
-0.01643441990017891,
0.034978192299604416,
0.004099912475794554,
-0.011456575244665146,
0.007637716829776764,
0.007684076204895973,
0.04207118600606918,
0.015530411154031754,
-0.010297589935362339,
-0.018149718642234802,
0.030017733573913574,
0.009671737439930439,
-0.020467691123485565,
-0.005070563405752182,
0.00456640450283885,
0.003068415215238929,
-0.024779118597507477,
0.009063269942998886,
-0.004525839816778898,
-0.022345248609781265,
-0.005592106841504574,
-0.0199461467564106,
-0.0029351317789405584,
0.0037811915390193462,
0.002025327878072858,
-0.012146172113716602,
0.026679854840040207,
-0.018033821135759354,
-0.012980641797184944,
0.015368152409791946,
-0.013548544608056545,
-0.030550867319107056,
0.041306257247924805,
-0.0066293990239501,
-0.005997751839458942,
-0.012180941179394722,
-0.024361882358789444,
-0.0017254402628168464,
-0.003430598182603717,
-0.00895316619426012,
0.03080584481358528,
-0.03609082102775574,
-0.0031669288873672485,
0.005015511531382799,
0.002887323498725891,
0.0036855752114206553,
-0.009723891504108906,
-0.03889556601643562,
0.038779668509960175,
-0.01757022552192211,
0.000616797769907862,
-0.01291110273450613,
-0.0151363555341959,
0.012134581804275513,
0.06884375959634781,
0.06596947461366653,
-0.026077182963490486,
0.018926238641142845,
-0.01085390243679285,
-0.01162462867796421,
-0.00330600724555552,
0.01670098677277565,
0.0025816410779953003,
-0.015229074284434319,
0.005093743093311787,
0.018740801140666008,
0.0770493820309639,
0.016979143023490906,
-0.017442736774683,
-0.01741955801844597,
-0.00949209462851286,
0.0044881729409098625,
0.006472936365753412,
-0.024408241733908653,
-0.03766703978180885,
0.020977644249796867,
-0.034445058554410934,
0.003928962163627148,
-0.04531634971499443,
-0.053266990929841995,
0.012273660860955715,
-0.006154214963316917,
0.017292069271206856,
0.009486299008131027,
0.025312252342700958,
-0.010002047754824162,
0.010703234933316708,
-0.02401418797671795,
-0.04112081974744797,
0.004305632319301367,
0.011021955870091915,
-0.009544248692691326,
0.013826701790094376,
-0.022229349240660667,
-0.00916757807135582,
0.022206168621778488,
0.03099128231406212,
0.01028599962592125,
0.03713390603661537,
-0.019146446138620377,
0.006658373866230249,
-0.0075623830780386925,
0.020282253623008728,
-0.029136905446648598,
0.006907555740326643,
0.015727438032627106,
-0.007145147770643234,
-0.016109904274344444,
-0.016585087403655052,
-0.03836243227124214,
-0.016225801780819893,
0.010761183686554432,
-0.00819403026252985,
0.05864468589425087,
0.006861196365207434,
0.018636493012309074,
-0.0018601723713800311,
0.022634994238615036,
-0.023759210482239723,
-0.014916148036718369,
0.03829289227724075,
0.019656401127576828,
-0.030713126063346863,
0.046475332230329514,
-0.013050180859863758,
-0.0053052580915391445,
0.02394464798271656,
-0.036276258528232574,
-0.027467966079711914,
-0.04218708723783493,
0.010471437126398087,
0.027630222961306572,
-0.01958686113357544,
-0.027537504211068153,
-0.0018369925674051046,
-0.0025454226415604353,
0.02452414110302925,
-0.03150123730301857,
-0.013166079297661781,
0.026100361719727516,
-0.010054202750325203,
0.012273660860955715,
0.04026316851377487,
0.029183264821767807,
-0.004114399664103985,
-0.033796027302742004,
0.02360854297876358,
0.007637716829776764,
0.0018181591294705868,
-0.0018761083483695984,
0.00456640450283885,
-0.030133632943034172,
-0.005644261371344328,
0.006438166368752718,
-0.05238616093993187,
-0.013629673980176449,
-0.034421879798173904,
-0.00019286249880678952,
-0.00723786698654294,
-0.00022564006212633103,
-0.022009141743183136,
-0.0004650430928450078,
0.009607993066310883,
0.01785997301340103,
-0.010581540875136852,
0.013479005545377731,
-0.00948050431907177,
-0.01645759865641594,
0.008593880571424961,
-0.027305707335472107,
-0.0016993629978969693,
0.014383015222847462,
-0.0053400276228785515,
0.035604044795036316,
-0.006693143397569656,
0.02103559300303459,
0.0032944174017757177,
0.014185987412929535,
-0.02069948799908161,
0.015368152409791946,
-0.0012915448751300573,
-0.022901561111211777,
0.021186262369155884,
0.0033378794323652983,
-0.020618358626961708,
-0.01706027239561081,
-0.017778843641281128,
0.028812389820814133,
-0.02461685985326767,
0.010314974002540112,
-0.01886828988790512,
-0.00330600724555552,
0.05354514718055725,
-0.07913555949926376,
0.0006037591956555843,
-0.003476957557722926,
0.000046676344936713576,
0.010842313058674335,
0.024199625477194786,
-0.049604594707489014,
-0.015866516157984734,
-0.0009634069865569472,
-0.01757022552192211,
0.03154759481549263,
-0.01730365864932537,
0.015599950216710567,
0.0027888098265975714,
0.0024251779541373253,
0.010083177126944065,
-0.013907830230891705,
-0.04401828348636627,
-0.013560134917497635,
0.02591492421925068,
-0.008790907450020313,
0.011410215869545937,
-0.019749119877815247,
0.04093538224697113,
-0.0058065191842615604,
0.017268890514969826,
-0.00939937587827444,
-0.04714754596352577,
-0.04679984971880913,
0.004966254346072674,
0.034352339804172516,
0.017512276768684387,
-0.03711072728037834,
0.028603771701455116,
0.014614812098443508,
-0.028256075456738472,
0.011728936806321144,
-0.004462095443159342,
0.0008337454637512565,
0.012586587108671665,
-0.01802222989499569,
0.03226616606116295,
0.03231252729892731,
0.012690895237028599,
-0.023596951737999916,
-0.004227401223033667,
-0.0008496814989484847,
-0.01879875175654888,
0.010656875558197498,
-0.012551817111670971,
-0.009190757758915424,
-0.03133897855877876,
-0.04306791350245476,
-0.01452209334820509,
0.007295816205441952,
-0.009022705256938934,
-0.004543224815279245,
0.04517726972699165,
0.016979143023490906,
0.01737319864332676,
-0.01802222989499569,
0.0540551021695137,
0.04858468845486641,
-0.003627625759691,
0.003190108574926853,
-0.022565454244613647,
-0.03727298602461815,
0.02360854297876358,
-0.04918736219406128,
0.029160084202885628,
-0.004082527942955494,
0.011004570871591568,
-0.030550867319107056,
0.006965504959225655,
-0.012412738986313343,
0.006229549180716276,
-0.009457324631512165,
-0.022461146116256714,
-0.0013140002265572548,
-0.004238991066813469,
-0.02767658233642578,
-0.053313352167606354,
-0.021139902994036674,
0.007011864800006151,
-0.014348245225846767,
-0.002987286075949669,
-0.034282803535461426,
0.027282526716589928,
0.0365312360227108,
-0.009486299008131027,
-0.02271612361073494,
-0.012795204296708107,
-0.008124491199851036,
-0.015298613347113132,
-0.01831197738647461,
-0.019262345507740974,
-0.014904558658599854,
-0.0042969402857124805,
0.012007093988358974,
-0.035024553537368774,
0.012505457736551762,
-0.04487593472003937,
0.01920439675450325,
-0.032497964799404144,
-0.03268340229988098,
-0.02021271362900734,
0.03212708979845047,
-0.018091769888997078,
0.02112831175327301,
-0.03822335600852966,
0.03201118856668472,
-0.025312252342700958,
0.03915054351091385,
0.007608742453157902,
0.0067452979274094105,
0.010141126811504364,
0.03956777974963188,
-0.023469464853405952,
0.001435693702660501,
-0.0057022105902433395,
0.08720209449529648,
0.024361882358789444,
-0.012065042741596699,
-0.030040914192795753,
-0.026795754209160805,
0.013641263358294964,
0.0025917822495102882,
0.03386556729674339,
-0.0018427876057103276,
0.005200949031859636,
0.021985962986946106,
0.022009141743183136,
0.005760159809142351,
0.018995778635144234,
-0.011914375238120556,
0.04415736347436905,
0.012041863054037094,
0.03356423228979111,
0.012656126171350479,
0.019262345507740974,
0.0010039715562015772,
-0.009237117134034634,
-0.02202073112130165,
-0.012041863054037094,
0.05558496341109276,
-0.011062520556151867,
-0.014858199283480644,
0.01295746210962534,
0.024153266102075577,
0.0038478330243378878,
-0.007011864800006151,
0.03662395477294922,
0.03263704106211662,
0.06457868963479996,
0.010523592121899128,
0.025381790474057198,
0.008518545888364315,
-0.006293293554335833,
-0.0186944417655468,
0.02589174546301365,
-0.047657500952482224,
0.04983639344573021,
-0.012760434299707413,
-0.03731934353709221,
0.013768752105534077,
-0.015194305218756199,
-0.01992296800017357,
-0.001224178820848465,
0.015229074284434319,
0.006003546994179487,
0.00353780435398221,
-0.015310203656554222,
0.02892828732728958,
-0.013965779915452003,
-0.030388610437512398,
0.012876332737505436,
0.004824278876185417,
0.006102060433477163,
0.013177669607102871,
0.036229897290468216,
-0.0032915198244154453,
0.0015342076076194644,
0.02074584737420082,
0.016446009278297424,
0.026054002344608307,
-0.023469464853405952,
-0.014695940539240837,
-0.008564905263483524,
0.0027337579522281885,
-0.0016935680760070682,
-0.02769976295530796,
-0.02716662921011448,
0.009694917127490044,
0.05883012339472771,
0.01922757551074028,
-0.04227980598807335,
-0.02137169986963272,
0.00692494073882699,
-0.050114549696445465,
-0.015426102094352245,
-0.06624763458967209,
0.03323971480131149,
0.04037906974554062,
-0.0037319345865398645,
-0.0025686025619506836,
0.02647123672068119,
-0.011363856494426727,
-0.0492800809442997,
-0.013409466482698917,
0.04170031100511551,
0.007208892144262791,
0.04914100095629692,
-0.012435918673872948,
0.035696763545274734,
0.00949209462851286,
0.01983024924993515,
0.011305906809866428,
-0.011960734613239765,
-0.04204800724983215,
0.005951392464339733,
-0.05920099839568138,
-0.04411100223660469,
0.008883627131581306,
-0.029021006077528,
0.0037319345865398645,
0.010094767436385155,
0.033749669790267944,
0.005001023877412081,
-0.005453028716146946,
0.001844236277975142,
-0.026958011090755463,
0.0283951535820961,
0.03224298730492592,
0.0032770326361060143,
0.023736031726002693,
0.0022339452989399433,
-0.010326564311981201,
-0.03133897855877876,
0.006600424647331238,
-0.015078405849635601,
0.03898828476667404,
0.02040974050760269,
-0.005229923874139786,
-0.038176994770765305,
-0.03154759481549263,
0.01296905241906643,
0.027444785460829735,
-0.008669214323163033,
-0.0014385912800207734,
-0.018775571137666702,
-0.017442736774683,
0.015205894596874714,
0.023481054231524467,
0.05493593215942383,
0.02895146794617176,
0.0024106905329972506,
-0.004114399664103985,
0.0018427876057103276,
0.03210390731692314,
0.014359834603965282,
-0.015912875533103943,
-0.00971230212599039,
-0.008588084951043129,
-0.010923441499471664,
0.020803796127438545,
-0.00614842027425766,
0.010413488373160362,
-0.026077182963490486,
0.019980916753411293,
0.011734732426702976,
0.017245709896087646,
-0.0008953165961429477,
-0.019146446138620377,
0.007585562765598297,
-0.0006772823981009424,
-0.013768752105534077,
0.00018887847545556724,
-0.012702485546469688,
-0.02074584737420082,
-0.005809416528791189,
0.00494017731398344,
-0.002010840456932783,
-0.03212708979845047,
0.009468914940953255,
0.013421056792140007,
0.03133897855877876,
-0.022542275488376617,
-0.016133083030581474,
-0.006594629492610693,
-0.0168168842792511,
-0.01730365864932537,
0.02464004047214985,
-0.02396782860159874,
0.002333907876163721,
-0.020826976746320724,
-0.01817289926111698,
-0.010031023062765598,
0.000917047553230077,
-0.0008974896627478302,
0.013131310231983662,
-0.004554814659059048,
0.029368702322244644,
0.0033031096681952477,
-0.026679854840040207,
-0.010303384624421597,
0.0010257024550810456,
-0.021232621744275093,
-0.038733307272195816,
0.028093818575143814,
-0.004696790128946304,
-0.06323426961898804,
0.012783613987267017,
-0.00019087048713117838,
0.011201598681509495,
0.02293633110821247,
0.002142675220966339,
0.008924190886318684,
0.019088497385382652,
0.009422555565834045,
0.012656126171350479,
-0.013803522102534771,
0.009144398383796215,
0.007040839176625013,
-0.02110513299703598,
-0.027467966079711914,
-0.0046069687232375145,
0.007313200738281012,
-0.0021586113143712282,
-0.0048793307505548,
-0.0015675283502787352,
0.02047928050160408,
0.005395079497247934,
0.006368627306073904,
-0.010813338682055473,
0.046475332230329514,
-0.0012205570237711072,
0.00712196808308363,
0.001048882259055972,
0.014104858040809631,
0.000015041916412883438,
-0.0035493941977620125,
0.0012502559693530202,
0.010042612440884113,
0.015391332097351551,
0.008993730880320072,
-0.010390308685600758,
-0.012238890863955021,
-0.005212538875639439,
-0.02450096234679222,
-0.011925964616239071,
0.06476413458585739,
-0.0330079160630703,
-0.05368422716856003,
0.04116717725992203,
0.009700711816549301,
-0.02081538550555706,
-0.0031321593560278416,
0.01153770461678505,
0.008657624945044518,
0.0065888348035514355,
-0.001637067529372871,
0.02973957732319832,
0.03979957476258278,
-0.02582220546901226,
0.016573498025536537,
0.015426102094352245,
-0.014811839908361435,
0.005447233561426401,
-0.0042245034128427505,
0.0065192957408726215,
0.023133357986807823,
-0.013189258985221386,
-0.01831197738647461,
0.002533832797780633,
0.0010640938999131322,
0.004775021690875292,
0.02524271234869957,
0.012111402116715908,
-0.021881652995944023,
0.033772848546504974,
-0.01446414366364479,
0.003442188026383519,
-0.009550043381750584,
-0.007968028075993061,
0.006507705897092819,
-0.030156811699271202,
-0.03198800981044769,
-0.024431422352790833,
0.007724640890955925,
-0.005632671527564526,
0.01546087209135294,
-0.00723786698654294,
0.02596128359436989,
0.0046069687232375145,
-0.05224708467721939,
-0.004351992160081863,
-0.0163880605250597,
0.022437967360019684,
-0.005603696685284376,
0.017778843641281128,
-0.017604995518922806,
-0.014220756478607655,
0.016272161155939102,
-0.012157761491835117,
0.025358611717820168,
0.02331879548728466,
-0.01600559428334236,
0.02025907300412655,
0.030481329187750816,
0.01886828988790512,
-0.02163826674222946,
-0.006577244959771633,
-0.07834744453430176,
0.014012139290571213,
-0.04272022098302841,
-0.011363856494426727,
0.0032277756836265326,
-0.040008191019296646,
-0.03470003604888916,
0.004467890597879887,
0.010222255252301693,
-0.006635194178670645,
0.007817359641194344,
-0.019053727388381958,
0.0015095791313797235,
-0.00864023994654417,
0.008396852761507034,
0.0010561258532106876,
-0.051458973437547684,
-0.012853153049945831,
-0.007973822765052319,
0.03889556601643562,
0.012818383984267712,
-0.0037000623997300863,
-0.03520999103784561,
0.008246184326708317,
0.005018408875912428,
0.00536030950024724,
-0.025752665475010872,
-0.004914100281894207,
0.008622854948043823,
-0.00012205570237711072,
0.04299837723374367,
-0.0006359934923239052,
-0.002047058893367648,
-0.01549564115703106,
-0.025428149849176407,
-0.006490320898592472,
0.015159535221755505,
0.0061194454319775105,
0.02521953359246254,
0.010454053059220314,
-0.03087538294494152,
0.0008330211276188493,
-0.013374697417020798,
-0.005803621839731932,
-0.05220072343945503,
-0.024315522983670235,
0.008165055885910988,
0.014116448350250721,
-0.027375247329473495,
-0.006351242773234844,
-0.0117926811799407,
0.03664713352918625,
0.01922757551074028,
-0.0058210063725709915,
-0.010413488373160362,
-0.012215711176395416,
-0.01612149365246296,
-0.004653328098356724,
0.022565454244613647,
-0.0017515174113214016,
0.04237252473831177,
-0.01768612489104271,
0.021209441125392914,
-0.015530411154031754,
0.03224298730492592,
0.004291145130991936,
0.0029699013102799654,
-0.02827925607562065,
-0.010396103374660015,
0.024130085483193398,
-0.0060151368379592896,
-0.005812314338982105,
0.006038316525518894,
0.01602877490222454,
-0.016863243654370308,
-0.025683127343654633,
0.02392146922647953,
-0.0199461467564106,
0.011763706803321838,
-0.02007363550364971,
-0.012887923046946526,
0.01361808367073536,
-0.015553590841591358,
-0.014128037728369236,
-0.0004070937866345048,
-0.023376746103167534,
-0.002049956237897277,
0.005256000906229019,
-0.0157622080296278,
-0.007232071831822395,
0.008924190886318684,
-0.015704259276390076,
0.0014624953037127852,
-0.007521818391978741,
-0.03724980726838112,
-0.06485684961080551,
0.004288247786462307,
0.003346571698784828,
-0.03354104980826378,
-0.01455686241388321,
0.00489671528339386,
0.014661171473562717,
0.02528907172381878,
-0.04304473474621773,
0.0076956660486757755,
0.031060822308063507,
0.02786201983690262,
0.0027917071711272,
0.017431147396564484,
0.023515824228525162,
0.017813613638281822,
0.0014378668274730444,
-0.008321519009768963,
-0.0034392906818538904,
-0.002942375373095274,
0.06467141211032867,
-0.026100361719727516,
0.03194165229797363,
0.020282253623008728,
0.0015733233885839581,
0.019401423633098602,
-0.013281977735459805,
-0.03449141979217529,
0.03226616606116295,
-0.02464004047214985,
-0.016283752396702766,
-0.034978192299604416,
-0.013061771169304848,
-0.014661171473562717,
0.022542275488376617,
0.029832296073436737,
-0.008385262452065945,
-0.0027627325616776943,
0.0014074434293434024,
0.0427897572517395,
-0.013108130544424057,
-0.02718980796635151,
0.03279929980635643,
0.045919019728899,
-0.006890171207487583,
-0.01884511113166809,
0.010013638064265251,
-0.026818932965397835,
-0.02644805796444416,
-0.009341426193714142,
0.012980641797184944,
-0.01384988147765398,
0.024964556097984314,
-0.023017460480332375,
0.0021528161596506834,
-0.00988035462796688,
0.017048683017492294,
0.027305707335472107,
-0.007614537142217159,
-0.008970550261437893,
0.03092174418270588,
-0.002055751159787178,
0.005664543714374304,
-0.026239439845085144,
-0.006930735427886248,
-0.010210665874183178,
-0.00007035406451905146,
-0.019911376759409904,
0.0027395528741180897,
-0.011195803992450237,
0.0013313849922269583,
-0.002407793188467622,
-0.006380217149853706,
0.00418104138225317,
0.0007185712456703186,
-0.01886828988790512,
0.035673584789037704,
-0.012829973362386227,
-0.00801438745111227,
-0.036832571029663086,
-0.01264453586190939,
0.0031408516224473715,
0.001976070925593376,
-0.04714754596352577,
0.00553995231166482,
0.00016262019926216453,
0.0033031096681952477,
0.019262345507740974,
0.031014462932944298,
0.0002421193930786103,
0.023828750476241112,
-0.018161308020353317,
0.01660826802253723,
0.00862864963710308,
0.005397976841777563,
-0.022658174857497215,
-0.0013690521009266376,
-0.012180941179394722,
-0.007011864800006151,
-0.030388610437512398,
-0.028093818575143814,
-0.03857104852795601,
-0.008321519009768963,
-0.004757637158036232,
0.008008592762053013,
0.0011770949931815267,
0.00015284126857295632,
-0.024825477972626686,
0.027282526716589928,
-0.028766030445694923,
0.0038478330243378878,
-0.02394464798271656,
0.016179442405700684,
0.0204560998827219,
0.03697165101766586,
-0.01703709177672863,
0.0217078048735857,
-0.007707255892455578,
0.03866376727819443,
-0.028070637956261635,
-0.013479005545377731,
0.020653128623962402,
-0.026726214215159416,
-0.02577584609389305,
0.019053727388381958,
-0.0004331709642428905,
-0.04346197098493576,
-0.005079255439341068,
-0.01131170243024826,
-0.009277681820094585,
0.0296468585729599,
-0.028858749195933342,
0.007759410422295332,
-0.009990458376705647,
0.03092174418270588,
0.017581814900040627,
0.02911372482776642,
-0.052108004689216614,
0.012366379611194134,
-0.011462369933724403,
-0.031756214797496796,
-0.005363207310438156,
-0.005884750746190548,
-0.024385062977671623,
0.012853153049945831,
-0.009242912754416466,
0.007006069645285606,
0.05182984843850136,
0.0035291120875626802,
0.003375546308234334,
0.00806074682623148,
-0.034398701041936874,
-0.005276283249258995,
0.017338428646326065,
-0.01165939774364233,
0.004853253252804279,
0.03321653604507446,
0.014487323351204395,
0.013652853667736053,
0.022322067990899086,
0.006907555740326643,
-0.015866516157984734,
-0.013490595854818821,
-0.008785112760961056,
0.013409466482698917,
0.004123092163354158,
0.0037000623997300863,
0.11191167682409286,
-0.014325065538287163,
-0.0180685892701149,
0.02707391045987606,
-0.027259347960352898,
-0.012922692112624645,
0.027259347960352898,
0.0032277756836265326,
0.018033821135759354,
-0.024848656728863716,
0.014568452723324299,
0.016469189897179604,
0.03449141979217529,
0.025358611717820168,
0.021093543618917465,
-0.007765205577015877,
0.0390346460044384,
0.032451603561639786,
0.016886424273252487,
-0.013421056792140007,
-0.016133083030581474,
0.0011423254618421197,
-0.0036508054472506046,
0.0315244160592556,
-0.03671667352318764,
-0.0075044333934783936,
-0.021024003624916077,
-0.021788934245705605,
-0.02168462611734867,
-0.028093818575143814,
0.014637991786003113,
0.013363107107579708,
0.024918196722865105,
0.0010546771809458733,
0.015542000532150269,
-0.02721298858523369,
-0.011097289621829987,
0.005783339496701956,
0.010935031808912754,
-0.006200574338436127,
-0.0193202942609787,
-0.0011618833523243666,
-0.01886828988790512,
-0.0038333458360284567,
0.010314974002540112,
-0.005050281062722206,
-0.019691169261932373,
-0.005722492933273315,
0.012030273675918579,
-0.02211344987154007,
-0.0031031847465783358,
-0.0037667041178792715,
0.02153395675122738,
-0.011960734613239765,
-0.041816212236881256,
-0.019215986132621765,
0.018972598016262054,
-0.00992671400308609,
-0.0034798551350831985,
-0.017790433019399643,
-0.00868659932166338,
-0.00385942286811769,
0.02101241424679756,
0.006826426833868027,
0.011137854307889938
] | 2024-07-04 | 1 | 38960662 | [
"CAR-T cell therapy",
"cell kinetics",
"conventional CAR-T therapies",
"CAR-T therapy",
"routine practice",
"innovative technologies",
"new technologies",
"dramatic results",
"relapsed or refractory hematopoietic tumors",
"BCMA",
"control",
"remission",
"CD19",
"infusion",
"patients",
"studies",
"half",
"momentum",
"the efficacy",
"thus efforts",
"the challenges",
"the development",
"this article",
"that",
"we",
"which",
"who"
] | [
"Chimeric antigen receptor",
"Long-term persistence",
"Memory T cells",
"Novel technology"
] | 0 | 10.11406/rinketsu.65.597 | [
"Uchibori"
] | [
"Division of Gene and Cell Therapy for Intractable Diseases, Jichi Medical University."
] | [
"38960662"
] | [] | 7.847038 | 4.02406 |
38960654 | 772 | [CAR T-cell therapy for malignant lymphoma]. | Advances in understanding of the pathogenesis of B-cell lymphoma have led to development of various novel targeted therapies. Among them, CD19-targeted chimeric antigen receptor (CAR) T-cell therapies for relapsed and refractory B-cell lymphomas have shown remarkable efficacy in clinical trials, and three CAR T-cell products are now available in Japan. Real-world evidence (RWE) has shown that these products can provide comparable efficacy to clinical trials in clinical practice, where CAR T-cells were administered in patients with wider range of backgrounds. This finding will certainly broaden the role of CAR T-cell therapies in the treatment of B-cell lymphoma. However, since about half of the patients treated with CAR T-cell therapy progress thereafter, there is an urgent need for risk stratification and optimized management of refractory cases. Here, we review the results of clinical trials and RWE of CAR T-cell therapy in B-cell lymphoma. | [
0.03557894006371498,
0.020907212048768997,
0.05827426537871361,
0.06565597653388977,
-0.0040261284448206425,
-0.037894319742918015,
-0.005868691019713879,
0.045596975833177567,
0.023211130872368813,
-0.002838348736986518,
-0.008132492192089558,
-0.009737213142216206,
-0.05666954815387726,
-0.0022809950169175863,
0.021606411784887314,
-0.010178511030972004,
0.03713781014084816,
-0.0026234309189021587,
-0.0051895505748689175,
0.044679995626211166,
0.014431019313633442,
0.004203793592751026,
-0.005840035155415535,
-0.02008192613720894,
-0.007542185019701719,
-0.013663046061992645,
-0.020311173051595688,
0.030627230182290077,
0.0009613992879167199,
-0.058457665145397186,
-0.015336539596319199,
-0.02002461440861225,
-0.025744296610355377,
0.0021964607294648886,
-0.00033706286922097206,
0.013812055811285973,
0.04151640459895134,
-0.01474050059914589,
-0.008831691928207874,
-0.03890300169587135,
0.0047654458321630955,
0.007318670395761728,
0.032644592225551605,
0.08202412724494934,
-0.06936976313591003,
-0.0014772022841498256,
0.010734431445598602,
-0.04211244359612465,
0.02391033060848713,
-0.023440375924110413,
-0.01019570417702198,
-0.00921567901968956,
-0.03926979377865791,
0.008344545029103756,
-0.06735239923000336,
0.05520237237215042,
-0.0011863467516377568,
0.025744296610355377,
0.011192923411726952,
-0.0024085131008177996,
0.03466195613145828,
-0.022878725081682205,
0.009066669270396233,
-0.017823856323957443,
-0.07477995753288269,
-0.009313108399510384,
-0.03470780327916145,
-0.018419895321130753,
0.008545135147869587,
0.04119545966386795,
0.01944003812968731,
-0.0204831063747406,
0.0234976876527071,
0.025881843641400337,
0.03612912818789482,
0.021824194118380547,
0.032094404101371765,
-0.0010065321112051606,
0.015072907321155071,
-0.0021649394184350967,
0.010740162804722786,
0.026409108191728592,
-0.010487992316484451,
-0.045917920768260956,
0.018121875822544098,
0.013021158054471016,
0.012287572026252747,
-0.015107294544577599,
-0.033057235181331635,
0.0000995786176645197,
-0.010075350292026997,
0.003048968268558383,
-0.06776504218578339,
0.07606373727321625,
-0.033836670219898224,
0.01647130586206913,
-0.023795707151293755,
-0.031085722148418427,
0.0492878332734108,
0.018167724832892418,
0.05359765514731407,
0.04289187863469124,
-0.003286810824647546,
-0.00796055793762207,
0.050984252244234085,
-0.014167387038469315,
-0.041218385100364685,
-0.025217032060027122,
0.03138374164700508,
-0.029801946133375168,
0.037344131618738174,
-0.003069027327001095,
-0.024300048127770424,
0.025079483166337013,
-0.02787628211081028,
-0.050846703350543976,
0.009616858325898647,
-0.01956612430512905,
-0.005332828965038061,
0.03385959565639496,
-0.019199330359697342,
0.04704122617840767,
0.03608328104019165,
-0.021526174619793892,
0.04160810261964798,
0.008436243049800396,
0.06276748329401016,
-0.03713781014084816,
-0.003063296200707555,
-0.06804013252258301,
0.028311848640441895,
0.00693468376994133,
-0.0030948175117373466,
-0.025217032060027122,
-0.08546280860900879,
0.02080405130982399,
-0.019738057628273964,
-0.020334096625447273,
-0.03819233924150467,
0.002520270412787795,
0.007152467034757137,
-0.021778345108032227,
0.003991741221398115,
-0.0020388541743159294,
-0.03541846573352814,
-0.0428001806139946,
-0.0033498534467071295,
0.003020312637090683,
-0.011651414446532726,
0.024162501096725464,
-0.049975570291280746,
0.025858920067548752,
0.04156225174665451,
-0.017181968316435814,
0.0003954489075113088,
-0.051626142114400864,
-0.003321197582408786,
0.05410199612379074,
-0.025515051558613777,
-0.02920590713620186,
-0.006516309920698404,
0.003513190895318985,
-0.05364350229501724,
-0.019176406785845757,
0.02741779014468193,
-0.030191663652658463,
-0.029710248112678528,
0.038169413805007935,
-0.059558041393756866,
0.014270546846091747,
-0.021090608090162277,
-0.014774887822568417,
-0.05488143116235733,
-0.033286482095718384,
-0.04289187863469124,
0.011536791920661926,
0.04431319981813431,
0.03161298856139183,
-0.005966120399534702,
-0.02860986813902855,
0.0043528033420443535,
-0.008482092060148716,
-0.007123811170458794,
-0.028495244681835175,
-0.0325758196413517,
0.006585083901882172,
0.006676781922578812,
0.017044421285390854,
-0.046880751848220825,
-0.021021833643317223,
0.006418880540877581,
0.019634896889328957,
0.046536885201931,
0.028816189616918564,
0.028311848640441895,
0.0015603038482367992,
0.016081588342785835,
0.050388213247060776,
-0.04438197612762451,
-0.016723476350307465,
0.02418542467057705,
-0.04493216425180435,
-0.031819310039281845,
0.00036034564254805446,
-0.016448382288217545,
-0.0034329548943787813,
0.006986263673752546,
0.027692886069417,
-0.03344695270061493,
-0.019783906638622284,
0.03667931631207466,
-0.015049982815980911,
-0.025354579091072083,
0.03502874821424484,
-0.04243338480591774,
-0.023016272112727165,
-0.010774550028145313,
0.07014919817447662,
0.011943702585995197,
0.007393175270408392,
0.033103086054325104,
0.0009836074896156788,
-0.017766544595360756,
-0.0038713873364031315,
-0.026890525594353676,
0.020597729831933975,
0.019955841824412346,
-0.026271561160683632,
0.01008681207895279,
-0.016035739332437515,
0.007857398129999638,
0.0000422895718656946,
0.026340335607528687,
-0.01765192113816738,
-0.02016216330230236,
-0.006487654522061348,
0.010751625522971153,
0.009410537779331207,
0.0540102943778038,
-0.021044759079813957,
0.002789634047076106,
0.020379945635795593,
0.04183734580874443,
-0.015909655019640923,
-0.004120692145079374,
-0.007565109524875879,
-0.0010545303812250495,
-0.05648614838719368,
0.04137885570526123,
-0.021342778578400612,
-0.010820399038493633,
0.02468976564705372,
-0.02280995063483715,
-0.026477882638573647,
0.051030103117227554,
0.018190650269389153,
0.030122889205813408,
-0.02851817011833191,
0.003289676271378994,
-0.005255458410829306,
-0.015176068060100079,
0.012310496531426907,
-0.014316396787762642,
-0.033240631222724915,
-0.06936976313591003,
0.008963508531451225,
0.0026993686333298683,
0.019921455532312393,
0.049975570291280746,
-0.006493385415524244,
0.025583824142813683,
0.004971766844391823,
0.06359276920557022,
-0.025262881070375443,
-0.03745875507593155,
0.011221579276025295,
0.005241130478680134,
0.01766338385641575,
0.002536030951887369,
0.029595624655485153,
0.029733171686530113,
0.030191663652658463,
-0.013089931569993496,
-0.04380885884165764,
0.009777330793440342,
-0.038169413805007935,
0.012528279796242714,
-0.008992164395749569,
-0.018947159871459007,
-0.006430342793464661,
0.007330132648348808,
-0.004639360588043928,
-0.033469878137111664,
-0.04023262858390808,
-0.003965951502323151,
-0.0321173295378685,
0.03690856322646141,
-0.04220414161682129,
-0.028220150619745255,
0.061116915196180344,
-0.02391033060848713,
0.019050320610404015,
-0.016138900071382523,
-0.014304934069514275,
0.003965951502323151,
0.01389229204505682,
0.00704930629581213,
-0.05671539530158043,
0.042227063328027725,
0.05423954129219055,
-0.007318670395761728,
0.018786687403917313,
0.030008267611265182,
-0.009754406288266182,
-0.01177176833152771,
-0.0019285298185423017,
0.029320530593395233,
-0.051213499158620834,
0.0049545736983418465,
-0.03910932317376137,
-0.027761658653616905,
-0.001600421848706901,
-0.03406591713428497,
0.027028072625398636,
-0.0022752638906240463,
-0.05478973314166069,
-0.026523731648921967,
-0.027165619656443596,
0.012757525779306889,
-0.05249727517366409,
0.01852305606007576,
-0.004682344384491444,
0.04809575527906418,
-0.030512608587741852,
-0.0021377166267484426,
-0.0012959548039361835,
0.0020073330961167812,
-0.045184336602687836,
0.031911008059978485,
-0.008235652931034565,
0.019772445783019066,
0.03901762515306473,
-0.028999585658311844,
0.041218385100364685,
0.018213573843240738,
0.007106618024408817,
0.030627230182290077,
-0.005241130478680134,
-0.02203051559627056,
-0.0008732829592190683,
0.017858242616057396,
-0.009204216301441193,
0.02372693456709385,
-0.009674170054495335,
-0.0003273915790487081,
0.028953736647963524,
-0.02723439410328865,
-0.030489683151245117,
0.011330470442771912,
-0.0010008009849116206,
-0.0140756880864501,
-0.006527772173285484,
-0.03239242359995842,
0.06859032809734344,
0.010482260957360268,
0.07418391853570938,
-0.0011233041295781732,
0.021709570661187172,
0.0054703764617443085,
-0.024620993062853813,
0.01453418005257845,
0.001158407423645258,
0.008264308795332909,
0.01879815012216568,
-0.0223514586687088,
0.017938479781150818,
0.03298846259713173,
0.02258070558309555,
0.007530722301453352,
0.032507047057151794,
0.02686760015785694,
0.004579183645546436,
-0.04484046623110771,
-0.027578262612223625,
-0.01778947003185749,
0.049975570291280746,
-0.00871133804321289,
-0.006728362292051315,
-0.05772407725453377,
0.028495244681835175,
-0.012849223800003529,
0.004020397085696459,
0.012264646589756012,
-0.01956612430512905,
-0.009954996407032013,
0.05318501219153404,
0.013789131306111813,
0.11086323857307434,
0.02925175614655018,
-0.00555347790941596,
-0.014110075309872627,
-0.034111764281988144,
-0.014545641839504242,
-0.033378180116415024,
0.010155586525797844,
0.015004133805632591,
0.012287572026252747,
0.006407418288290501,
0.02856401912868023,
-0.016459843143820763,
-0.022294148802757263,
0.03479950129985809,
0.0441756546497345,
0.014786350540816784,
0.01158837229013443,
0.002336873672902584,
-0.01327332854270935,
0.041814424097537994,
-0.019084706902503967,
0.050296515226364136,
0.046559810638427734,
-0.031039873138070107,
0.019818294793367386,
-0.008057987317442894,
0.004435905255377293,
-0.013009695336222649,
0.0290683601051569,
0.02195028029382229,
-0.003258154960349202,
-0.05336840823292732,
-0.02847232110798359,
0.0627216324210167,
0.010430681519210339,
-0.016769325360655785,
0.0008603879250586033,
0.030581381171941757,
-0.015978427603840828,
0.018270885571837425,
-0.027945054695010185,
0.020655041560530663,
0.006006238516420126,
0.000924146908801049,
-0.019543198868632317,
-0.02783043310046196,
0.02865571714937687,
0.001829667598940432,
0.0056480420753359795,
0.04069111868739128,
-0.016138900071382523,
0.004223852884024382,
-0.006418880540877581,
-0.030214589089155197,
0.0004201644624117762,
-0.05336840823292732,
-0.06799428910017014,
-0.00983464252203703,
0.031062796711921692,
-0.06579352915287018,
-0.009341764263808727,
0.01993291638791561,
0.015989890322089195,
-0.03457025811076164,
0.008613908663392067,
-0.027692886069417,
-0.01004096306860447,
0.05598181113600731,
0.04896688833832741,
0.001851159380748868,
0.03133789077401161,
-0.027990905568003654,
0.01628790982067585,
-0.004842816386371851,
-0.02645495906472206,
-0.0011942270211875439,
-0.01670055277645588,
0.07234995812177658,
-0.0014607252087444067,
0.007639614399522543,
0.018775226548314095,
0.005903077777475119,
0.007496335543692112,
0.011760306544601917,
-0.01734244078397751,
-0.018419895321130753,
0.04782066121697426,
0.01783531904220581,
-0.005301307886838913,
0.00005220713501330465,
-0.041539326310157776,
0.025446277111768723,
-0.01997876539826393,
-0.0044731576927006245,
0.03750460222363472,
-0.009416269138455391,
-0.0029114207718521357,
-0.018958622589707375,
0.007610958535224199,
0.00515516335144639,
-0.013021158054471016,
0.04307527467608452,
-0.008023601025342941,
0.026294486597180367,
0.009169829078018665,
0.006338644772768021,
0.04403810575604439,
0.06400541216135025,
-0.008270040154457092,
0.05387274920940399,
0.00606928113847971,
-0.004957438912242651,
-0.05749483034014702,
-0.015978427603840828,
0.02810552716255188,
-0.018098950386047363,
-0.030397985130548477,
-0.0024099459405988455,
-0.05818256735801697,
-0.009891953319311142,
-0.011531060561537743,
-0.024345897138118744,
-0.0123219583183527,
-0.01003523264080286,
0.01412153709679842,
-0.00034386859624646604,
0.02404787763953209,
-0.017078807577490807,
-0.01469465158879757,
-0.04007215425372124,
-0.03156713768839836,
-0.031223269179463387,
0.04328159615397453,
-0.009318838827311993,
-0.008189803920686245,
0.01218441128730774,
0.009456386789679527,
-0.03851328417658806,
-0.03454733267426491,
0.026707127690315247,
0.007375981658697128,
-0.023795707151293755,
0.024850238114595413,
-0.0011268861126154661,
-0.0050118849612772465,
-0.026111088693141937,
-0.01751437410712242,
0.024483444169163704,
-0.002543194917961955,
-0.03252996876835823,
-0.008092374540865421,
-0.005043406039476395,
0.03461610525846481,
-0.03466195613145828,
-0.0006769913015887141,
0.00013548781862482429,
0.02253485657274723,
-0.028265999630093575,
-0.014339321292936802,
-0.024666842073202133,
-0.009777330793440342,
-0.045459430664777756,
-0.017892630770802498,
-0.01225318480283022,
-0.007719850167632103,
-0.01679225079715252,
-0.02363523654639721,
0.012505355291068554,
-0.0011311843991279602,
-0.021388627588748932,
-0.0400492288172245,
0.029801946133375168,
-0.019371265545487404,
-0.001660598791204393,
-0.02363523654639721,
-0.015714796259999275,
0.03580818325281143,
-0.00024088712234515697,
0.00004535662810667418,
0.005066331010311842,
-0.020826974883675575,
0.029274681583046913,
-0.02345183864235878,
-0.02276410162448883,
-0.045826222747564316,
0.04270848259329796,
-0.016448382288217545,
0.011571178212761879,
-0.029916569590568542,
-0.04442782327532768,
-0.002495913067832589,
0.010797474533319473,
0.032048553228378296,
-0.0015846611931920052,
0.0395219661295414,
0.004900127649307251,
-0.040393099188804626,
0.016689090058207512,
0.01412153709679842,
-0.0007199749234132469,
-0.03138374164700508,
0.01628790982067585,
0.010975140146911144,
-0.00612659240141511,
-0.0022437425795942545,
-0.041997820138931274,
-0.015290690585970879,
0.032965537160634995,
0.005914540030062199,
-0.04353376477956772,
0.015795031562447548,
-0.0015316481003537774,
0.050434064120054245,
0.03553308919072151,
-0.018878387287259102,
0.014878048561513424,
0.03399714455008507,
0.017273666337132454,
-0.019600510597229004,
-0.013789131306111813,
0.003091951832175255,
-0.014419556595385075,
-0.030329210683703423,
0.018866924569010735,
0.0038971775211393833,
0.013685970567166805,
0.01010400615632534,
-0.031177420169115067,
-0.013685970567166805,
0.006034893915057182,
0.025217032060027122,
-0.032277800142765045,
-0.0010430681286379695,
-0.042823102325201035,
-0.00692322151735425,
0.025927692651748657,
0.01578356884419918,
-0.027761658653616905,
0.03718365728855133,
0.006384493783116341,
-0.02948100119829178,
0.01327332854270935,
-0.008545135147869587,
0.007416099775582552,
-0.009548084810376167,
-0.026752978563308716,
0.038169413805007935,
-0.030443834140896797,
-0.03369912505149841,
0.01557724829763174,
0.00017730725812725723,
-0.01824796013534069,
-0.01660885289311409,
-0.040530648082494736,
0.026202788576483727,
-0.009232872165739536,
0.020953061059117317,
-0.012895072810351849,
-0.012883610092103481,
0.014946822077035904,
0.061346158385276794,
0.07326693832874298,
-0.014992671087384224,
0.04055356979370117,
-0.018316734582185745,
-0.02400202862918377,
0.018912773579359055,
0.004381459206342697,
0.02149178832769394,
-0.0012257483322173357,
0.02377278357744217,
0.022064901888370514,
0.06460145115852356,
0.0011404975084587932,
-0.0002115150127792731,
-0.023119432851672173,
-0.021870043128728867,
-0.011496673338115215,
-0.01005815714597702,
-0.025171181187033653,
-0.0395219661295414,
0.024758540093898773,
0.009977920912206173,
0.008201266638934612,
-0.012929460033774376,
-0.07097448408603668,
-0.006378762889653444,
-0.0009055206901393831,
0.016161823645234108,
-0.0026678473223000765,
0.019955841824412346,
-0.002107627922669053,
-0.011932240799069405,
-0.02017362415790558,
-0.024345897138118744,
0.011238772422075272,
0.003524653147906065,
0.002111926442012191,
0.029503926634788513,
-0.03326355665922165,
-0.030650155618786812,
0.0027151291724294424,
0.029710248112678528,
0.013743282295763493,
0.041951969265937805,
-0.02764703519642353,
0.0029056896455585957,
0.006361569277942181,
-0.02217952534556389,
-0.042868953198194504,
0.019107632339000702,
0.014843661338090897,
0.011210116557776928,
-0.026477882638573647,
-0.02012777514755726,
-0.04133300483226776,
-0.008774380199611187,
-0.004971766844391823,
-0.010167048312723637,
0.04901273921132088,
-0.0006533503765240312,
0.009708557277917862,
-0.018305271863937378,
0.03727535530924797,
-0.03823819011449814,
0.01083759218454361,
0.040393099188804626,
0.030879400670528412,
-0.04298357665538788,
0.05533992126584053,
-0.029137132689356804,
-0.029366379603743553,
0.0002629162045195699,
-0.01702149584889412,
-0.016127437353134155,
-0.015118756331503391,
-0.005599327385425568,
0.025125332176685333,
-0.01893569715321064,
-0.020460182800889015,
-0.0013203121488913894,
-0.015004133805632591,
0.023337217047810555,
-0.04694952815771103,
-0.05290991812944412,
0.02764703519642353,
-0.008728531189262867,
0.01956612430512905,
0.040989138185977936,
0.012952384538948536,
-0.011760306544601917,
-0.021663721650838852,
0.023887405171990395,
0.007295745424926281,
0.004874337464570999,
-0.017273666337132454,
0.013078469783067703,
-0.05763237923383713,
0.005645176395773888,
-0.015359464101493359,
-0.051671989262104034,
-0.030604306608438492,
-0.027578262612223625,
0.015898192301392555,
-0.001419890788383782,
-0.0013160138623788953,
0.0028884962666779757,
-0.002325411420315504,
0.008384662680327892,
0.025033634155988693,
-0.007490604650229216,
-0.024758540093898773,
-0.019130557775497437,
0.0010867681121453643,
0.006797136273235083,
0.005415930412709713,
-0.010602615773677826,
0.02377278357744217,
-0.015141680836677551,
0.023749858140945435,
-0.014843661338090897,
0.019646359607577324,
-0.006877372041344643,
-0.017640460282564163,
-0.019371265545487404,
0.006974801421165466,
-0.017537299543619156,
-0.0032037091441452503,
0.015118756331503391,
0.01019570417702198,
-0.032690443098545074,
-0.019199330359697342,
-0.02340598963201046,
0.013972527347505093,
-0.044771693646907806,
0.021044759079813957,
-0.009439193643629551,
0.016448382288217545,
0.025652598589658737,
-0.07299184054136276,
-0.025400428101420403,
-0.013009695336222649,
-0.012849223800003529,
-0.02117084339261055,
0.003057565074414015,
-0.015256304293870926,
-0.014304934069514275,
-0.010390562936663628,
-0.00933030154556036,
0.037252433598041534,
-0.05809086933732033,
-0.0244146715849638,
-0.002994522452354431,
-0.025767220184206963,
0.0016075856983661652,
-0.010545304045081139,
-0.037344131618738174,
-0.018649140372872353,
0.016987109556794167,
0.02728024311363697,
0.025744296610355377,
-0.018729377537965775,
0.037023186683654785,
0.0020016019698232412,
0.002954404568299651,
0.0057626646012067795,
-0.017411213368177414,
-0.03408884257078171,
0.004195197019726038,
0.036702241748571396,
0.037848472595214844,
-0.01092929020524025,
0.009553816169500351,
0.00857952143996954,
-0.025492126122117043,
0.011897853575646877,
-0.0015287825372070074,
0.016253523528575897,
-0.021468862891197205,
-0.012356345541775227,
0.027303166687488556,
0.023887405171990395,
-0.003054699394851923,
0.01241365633904934,
-0.016826637089252472,
-0.02916005812585354,
-0.013708895072340965,
0.012734600342810154,
-0.02432297356426716,
0.028678642585873604,
-0.01738828979432583,
-0.02184711955487728,
0.007456217426806688,
-0.000006324406513158465,
-0.0015560054453089833,
0.006309988908469677,
0.031727612018585205,
0.02253485657274723,
-0.009651245549321175,
-0.011599834077060223,
0.04243338480591774,
0.03175053372979164,
-0.006728362292051315,
0.011296084150671959,
-0.013823517598211765,
-0.021560560911893845,
0.02948100119829178,
-0.029664399102330208,
0.021686647087335587,
-0.020586267113685608,
0.003031774889677763,
-0.0488293431699276,
0.038215264678001404,
0.0008281502523459494,
0.022660940885543823,
0.007347325794398785,
-0.020219475030899048,
0.01453418005257845,
-0.002994522452354431,
-0.011141343042254448,
-0.04782066121697426,
-0.02920590713620186,
0.009026550687849522,
-0.029274681583046913,
-0.019772445783019066,
-0.013640121556818485,
0.014958284795284271,
0.03617497906088829,
-0.046147167682647705,
-0.008682682178914547,
0.017308052629232407,
0.005513359792530537,
0.002743785036727786,
-0.005112180020660162,
-0.0053156353533267975,
-0.007565109524875879,
-0.006034893915057182,
0.001869785599410534,
-0.03491412475705147,
0.03995753079652786,
-0.023704009130597115,
0.022007590159773827,
-0.01965782232582569,
0.011783231049776077,
-0.032323647290468216,
0.04392348229885101,
-0.008057987317442894,
-0.0012816269882023335,
-0.04197489470243454,
0.038490358740091324,
0.0015603038482367992,
0.026019390672445297,
-0.005158029031008482,
0.015233379788696766,
0.007479142397642136,
0.04147055372595787,
-0.01679225079715252,
0.004498947411775589,
0.020288247615098953,
0.07528430223464966,
0.03562478721141815,
0.005908809136599302,
-0.024873163551092148,
0.007553647272288799,
-0.005954658146947622,
0.011485211551189423,
0.01108403131365776,
0.006252677645534277,
0.010000845417380333,
0.04000338166952133,
0.021743958815932274,
-0.008705606684088707,
-0.0011096926173195243,
-0.02276410162448883,
0.04832500219345093,
0.018098950386047363,
0.03658761829137802,
0.01234488282352686,
0.009255796670913696,
0.003991741221398115,
-0.0052010128274559975,
-0.00509785208851099,
0.025996467098593712,
0.05836596339941025,
-0.017915554344654083,
-0.030031191185116768,
0.021044759079813957,
0.01345672458410263,
0.020047539845108986,
-0.019864143803715706,
0.01948588714003563,
0.03275921568274498,
0.06739825010299683,
0.004851412959396839,
0.044863391667604446,
0.011055375449359417,
-0.01213856227695942,
-0.011989552527666092,
0.030191663652658463,
-0.029985342174768448,
0.05451463535428047,
-0.012998233549296856,
-0.011886391788721085,
0.034478560090065,
-0.008017869666218758,
-0.018534518778324127,
-0.0005319217452779412,
0.010023769922554493,
-0.016093051061034203,
0.008424781262874603,
-0.059878986328840256,
0.03145251423120499,
0.0035418467596173286,
-0.001381205627694726,
-0.008098105899989605,
0.004894396290183067,
0.025033634155988693,
0.036748092621564865,
0.02902251109480858,
-0.009869028814136982,
0.012975309044122696,
-0.007387443911284208,
0.04007215425372124,
0.008447705768048763,
-0.015451163053512573,
-0.015772106125950813,
-0.050067268311977386,
0.002490181941539049,
-0.0038627907633781433,
-0.007330132648348808,
-0.03805479407310486,
0.025079483166337013,
0.052084632217884064,
0.033561576157808304,
-0.035739410668611526,
-0.027990905568003654,
0.0038484628312289715,
-0.026065239682793617,
-0.0295268502086401,
-0.046147167682647705,
0.003252423834055662,
0.06327182054519653,
-0.01031032670289278,
-0.00609220564365387,
0.024391746148467064,
0.0008037928491830826,
-0.059833139181137085,
0.029939493164420128,
0.051809538155794144,
0.02709684707224369,
0.015187529847025871,
-0.019050320610404015,
0.018855461850762367,
0.035280920565128326,
-0.013697433285415173,
0.005908809136599302,
-0.0101269306614995,
-0.03266751766204834,
-0.0015130218816921115,
-0.030994024127721786,
-0.043419141322374344,
-0.019015934318304062,
-0.01633375883102417,
0.011685801669955254,
0.00504054082557559,
0.05460633337497711,
0.029549775645136833,
-0.007582302670925856,
0.010132662020623684,
-0.03193392977118492,
0.02705099806189537,
0.014568566344678402,
0.008585252799093723,
-0.005476107355207205,
-0.01067712064832449,
0.005123642273247242,
-0.019726594910025597,
-0.007307208143174648,
-0.005616520531475544,
0.061025217175483704,
0.026661278679966927,
-0.024850238114595413,
-0.004097767639905214,
-0.030099965631961823,
-0.012849223800003529,
0.044955089688301086,
-0.03672516718506813,
0.008608177304267883,
-0.0005938897375017405,
-0.030008267611265182,
0.0010903500951826572,
0.020219475030899048,
0.028541093692183495,
0.0139610655605793,
-0.002983060199767351,
0.012081250548362732,
-0.0027222931385040283,
0.03741290420293808,
0.012631440535187721,
-0.002048883819952607,
0.008613908663392067,
-0.006625202018767595,
0.005926002282649279,
0.027349015697836876,
0.033103086054325104,
0.008820230141282082,
-0.018545979633927345,
0.020998910069465637,
-0.0055276877246797085,
0.01806456409394741,
0.024024954065680504,
0.005914540030062199,
0.007748506031930447,
0.019336877390742302,
-0.023749858140945435,
0.018465744331479073,
-0.019371265545487404,
-0.022798487916588783,
0.013949602842330933,
0.005791320465505123,
-0.004372862633317709,
-0.030787702649831772,
0.01239073183387518,
0.036060355603694916,
0.005115045700222254,
-0.000463148026028648,
-0.006602277047932148,
0.025171181187033653,
-0.027257317677140236,
-0.02135424129664898,
0.026661278679966927,
-0.016803713515400887,
-0.007559378165751696,
0.005221071653068066,
-0.008258577436208725,
-0.02221391163766384,
-0.005880153272300959,
0.042548008263111115,
0.010316058062016964,
0.011301814578473568,
0.03560186177492142,
-0.00418660044670105,
-0.03580818325281143,
-0.011479480192065239,
0.003968816716223955,
-0.0009871894726529717,
-0.018442818894982338,
0.037848472595214844,
-0.017915554344654083,
-0.045505277812480927,
0.02400202862918377,
0.003238096134737134,
-0.018763763830065727,
0.00029515387723222375,
-0.0008897600346244872,
-0.007656807545572519,
0.027807507663965225,
0.018442818894982338,
-0.004510410130023956,
-0.008894735015928745,
-0.014304934069514275,
-0.02473561465740204,
-0.023474764078855515,
-0.04380885884165764,
0.0353955402970314,
-0.0012902236776426435,
0.009427730925381184,
-0.04257093369960785,
-0.0056365798227488995,
0.021606411784887314,
0.0013525498798117042,
0.0006952593685127795,
-0.003309735329821706,
0.006573621649295092,
-0.001399115426465869,
0.00994926504790783,
0.01409861259162426,
0.019692208617925644,
-0.008086643181741238,
0.02126254141330719,
0.0007471978315152228,
0.016391070559620857,
0.006218290887773037,
0.03551016375422478,
-0.00832735188305378,
0.011863467283546925,
-0.018121875822544098,
-0.014981209300458431,
-0.0019958706106990576,
0.06363862007856369,
-0.03826111555099487,
-0.030306287109851837,
0.029045434668660164,
-0.0025288669858127832,
-0.03358450159430504,
0.0056365798227488995,
0.0035848303232342005,
0.02340598963201046,
-0.005066331010311842,
-0.009393343701958656,
0.02778458409011364,
0.046513959765434265,
-0.029939493164420128,
0.00702638179063797,
0.01345672458410263,
-0.01778947003185749,
0.01994437910616398,
-0.019084706902503967,
0.015760645270347595,
0.00015402448480017483,
0.004513275343924761,
-0.02423127368092537,
0.0312003456056118,
-0.016161823645234108,
0.0054933009669184685,
0.037298280745744705,
-0.0010767385829240084,
0.007204047404229641,
0.010442143306136131,
0.0014234727714210749,
0.01710173301398754,
-0.011674338951706886,
-0.013800593093037605,
0.004372862633317709,
-0.028128452599048615,
-0.023348677903413773,
-0.015382388606667519,
0.016952723264694214,
-0.016872486099600792,
0.015187529847025871,
-0.010109737515449524,
0.008092374540865421,
0.016643241047859192,
-0.0353267677128315,
-0.015565785579383373,
0.00606928113847971,
0.011502404697239399,
0.00021599246247205883,
0.003751033451408148,
-0.044955089688301086,
-0.02404787763953209,
0.02423127368092537,
-0.006373031530529261,
0.0003771808696910739,
0.02336014062166214,
-0.0022509065456688404,
0.009800255298614502,
0.020414333790540695,
0.008934852667152882,
-0.017778007313609123,
0.005298442207276821,
-0.04731632024049759,
0.01714758202433586,
-0.025239955633878708,
-0.022660940885543823,
0.009513698518276215,
-0.013376489281654358,
-0.05575256422162056,
-0.024804389104247093,
0.029870720580220222,
0.005152298137545586,
-0.0020016019698232412,
0.0023769917897880077,
0.020322633907198906,
0.009507967159152031,
0.01028740219771862,
-0.012069787830114365,
-0.03658761829137802,
0.024620993062853813,
0.011261696927249432,
0.024024954065680504,
0.018832538276910782,
0.029733171686530113,
-0.023658160120248795,
0.015428238548338413,
-0.011301814578473568,
0.01714758202433586,
-0.018087489530444145,
-0.00008001213427633047,
-0.00781154865399003,
0.009278721176087856,
0.03443270921707153,
0.005229668226093054,
0.023428915068507195,
-0.0034157615154981613,
-0.022145139053463936,
0.0007231986382976174,
0.014889510348439217,
0.002579014515504241,
0.02723439410328865,
0.011364857666194439,
-0.05304746329784393,
0.00032112313783727586,
0.0010208599269390106,
-0.009909147396683693,
-0.04348791763186455,
-0.009731481783092022,
0.021915892139077187,
0.004745387006551027,
-0.01168007031083107,
-0.009828911162912846,
0.00778862414881587,
0.00862537045031786,
0.013708895072340965,
-0.010505186393857002,
-0.036518845707178116,
-0.016081588342785835,
-0.013284790329635143,
0.0057512023486196995,
0.019462963566184044,
0.016677627339959145,
0.029733171686530113,
0.02400202862918377,
0.007880322635173798,
-0.03413468971848488,
0.032048553228378296,
-0.004756849259138107,
0.010379101149737835,
-0.007765699177980423,
-0.02262655459344387,
0.018179187551140785,
0.008522210642695427,
-0.007817279547452927,
0.03569355979561806,
0.0246439166367054,
-0.012046863324940205,
-0.0031320699490606785,
0.04406103119254112,
0.0003207649278920144,
0.006470460910350084,
-0.009891953319311142,
-0.006854447536170483,
-0.008436243049800396,
-0.004100633319467306,
-0.004796966910362244,
-0.010917828418314457,
-0.027073921635746956,
-0.010493723675608635,
0.0018998740706592798,
-0.016253523528575897,
-0.01875230111181736,
0.0026936375070363283,
-0.031131571158766747,
0.013261865824460983,
0.017502911388874054,
-0.03608328104019165,
-0.05680709332227707,
-0.023211130872368813,
-0.006006238516420126,
-0.04238753765821457,
-0.011124149896204472,
-0.017216354608535767,
0.03424931317567825,
0.03881130367517471,
-0.033332329243421555,
0.02409372664988041,
0.025285804644227028,
0.014774887822568417,
0.0174685250967741,
0.02003607712686062,
0.026134014129638672,
0.020872823894023895,
-0.015348002314567566,
0.0034071647096425295,
-0.02902251109480858,
-0.00841904990375042,
0.03628959879279137,
-0.018179187551140785,
0.025262881070375443,
-0.00007710178761044517,
-0.025102408602833748,
0.04034724831581116,
-0.00618390366435051,
-0.014923897571861744,
0.026042316108942032,
-0.0012572696432471275,
-0.00928445253521204,
-0.01343380007892847,
0.00694614602252841,
0.008871810510754585,
0.03138374164700508,
0.04374008625745773,
-0.013663046061992645,
-0.016998572275042534,
0.03777969628572464,
0.028449395671486855,
-0.021755419671535492,
-0.031681761145591736,
-0.008126761764287949,
0.025056559592485428,
0.013021158054471016,
-0.032598745077848434,
0.009198484942317009,
-0.02244315855205059,
-0.04387763515114784,
-0.020826974883675575,
0.012895072810351849,
-0.02787628211081028,
-0.0007428994867950678,
-0.004263970535248518,
0.0033613156992942095,
-0.0011440794914960861,
0.035785261541604996,
0.002983060199767351,
0.006917490158230066,
-0.012791912071406841,
0.010849054902791977,
-0.027211468666791916,
-0.011731650680303574,
-0.004327013157308102,
0.0028483783826231956,
-0.020632116124033928,
-0.003928699064999819,
-0.01642545685172081,
0.02363523654639721,
0.012837761081755161,
0.007198316045105457,
-0.007908977568149567,
-0.021881505846977234,
-0.012241722084581852,
-0.007290014531463385,
-0.017090270295739174,
0.0003209440328646451,
-0.0013754743849858642,
-0.003473073011264205,
-0.04174564778804779,
-0.0029486732091754675,
0.003521787701174617,
0.024437595158815384,
-0.033378180116415024,
0.00871133804321289,
-0.001144795911386609,
-0.005662369541823864,
0.03418054059147835,
0.04289187863469124,
0.005175222642719746,
0.010659926570951939,
-0.0395907387137413,
0.0015717661008238792,
-0.008453436195850372,
0.03470780327916145,
-0.02805967815220356,
-0.018225036561489105,
0.016574466601014137,
0.016585929319262505,
-0.015302153304219246,
-0.013823517598211765,
-0.03626667708158493,
-0.01239073183387518,
-0.009416269138455391,
-0.000582785636652261,
0.0023655295372009277,
0.007324401289224625,
-0.009078131057322025,
0.0091927545145154,
-0.028220150619745255,
0.01241365633904934,
-0.003286810824647546,
0.02732609212398529,
0.026386184617877007,
0.02764703519642353,
-0.012287572026252747,
0.006499116774648428,
0.004917321261018515,
0.037389978766441345,
-0.032461196184158325,
0.0045304689556360245,
0.03136081621050835,
-0.012459506280720234,
-0.04357961565256119,
0.019955841824412346,
0.014706114307045937,
-0.004536199849098921,
-0.006671051029115915,
0.011313277296721935,
-0.01660885289311409,
0.008894735015928745,
-0.029756097123026848,
0.018087489530444145,
-0.014282009564340115,
0.030925249680876732,
-0.0007507798145525157,
0.02126254141330719,
-0.04151640459895134,
0.030764777213335037,
-0.030237512663006783,
-0.021342778578400612,
0.0006003372836858034,
-0.015852343291044235,
-0.023211130872368813,
-0.010866248048841953,
-0.0018253691960126162,
0.013078469783067703,
0.05419369414448738,
-0.01179469283670187,
-0.02409372664988041,
0.011651414446532726,
-0.01325040403753519,
-0.005653772968798876,
0.037114884704351425,
-0.008367469534277916,
0.029366379603743553,
0.026271561160683632,
0.021514711901545525,
-0.005289845634251833,
0.03413468971848488,
0.00832735188305378,
-0.0267759021371603,
-0.007473411038517952,
-0.013812055811285973,
0.0014729038812220097,
-0.03881130367517471,
0.006820060778409243,
0.11874929070472717,
-0.017778007313609123,
-0.013032619841396809,
0.03175053372979164,
-0.013468187302350998,
-0.011496673338115215,
0.005579268094152212,
0.0015717661008238792,
0.03589988127350807,
-0.018270885571837425,
0.012539741583168507,
0.017010033130645752,
0.01471757609397173,
0.030306287109851837,
0.016345221549272537,
-0.003481669584289193,
0.010671389289200306,
0.028678642585873604,
0.022878725081682205,
0.0023841557558625937,
0.007588034030050039,
0.0020288247615098953,
-0.01970367133617401,
-0.0031779189594089985,
-0.015680408105254173,
-0.00868841353803873,
-0.01683809980750084,
0.013181629590690136,
-0.006390225142240524,
-0.013204554095864296,
-0.006625202018767595,
-0.012654365040361881,
-0.0019958706106990576,
-0.006986263673752546,
-0.015485549345612526,
-0.00789178442209959,
-0.019634896889328957,
0.003478804137557745,
0.03516629710793495,
0.020517494529485703,
0.01239073183387518,
-0.005009019281715155,
-0.015302153304219246,
0.006447536405175924,
0.03230072557926178,
-0.02181273140013218,
-0.02682175114750862,
-0.007668269798159599,
-0.0006974085117690265,
0.0156001728028059,
-0.0174685250967741,
0.0052697863429784775,
0.003017446957528591,
-0.017915554344654083,
-0.015004133805632591,
-0.04814160615205765,
0.008768649771809578,
0.0010165615240111947,
0.007295745424926281,
-0.02838062308728695,
-0.0169756468385458,
0.008063718676567078,
0.011359126307070255,
0.008103837259113789,
0.004501813091337681
] | 2024-07-04 | 1 | 38960654 | [
"CAR T-cell therapy progress",
"CAR T-cell therapies",
"CAR T-cell therapy",
"various novel targeted therapies",
"clinical trials",
"CAR T-cells",
"clinical practice",
"CAR) T-cell therapies",
"B-cell lymphoma",
"three CAR T-cell products",
"lymphomas",
"comparable efficacy",
"remarkable efficacy",
"risk stratification",
"optimized management",
"refractory cases",
"RWE",
"relapsed and refractory B-cell lymphomas",
"wider range",
"patients",
"CD19-targeted chimeric antigen receptor",
"development",
"understanding",
"backgrounds",
"Advances",
"Real-world evidence",
"Japan",
"an urgent need",
"these products",
"the patients"
] | [
"B-cell lymphoma",
"Chimeric antigen receptor (CAR) T-cell therapy",
"Real-world evidence (RWE)"
] | 0 | 10.11406/rinketsu.65.536 | [
"Jo",
"Arai"
] | [
"Department of Hematology, Graduate School of Medicine, Kyoto University.\nCenter for Research and Application of Cellular Therapy, Kyoto University Hospital.",
"Department of Hematology, Graduate School of Medicine, Kyoto University.\nCenter for Research and Application of Cellular Therapy, Kyoto University Hospital."
] | [
"38960654"
] | [] | 7.057811 | 4.833054 |
38960449 | 773 | Development of novel humanized CD19/BAFFR bicistronic chimeric antigen receptor T cells with potent antitumor activity against B-cell lineage neoplasms. | Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable efficacy in treating advanced B-cell malignancies by targeting CD19, but antigen-negative relapses and immune responses triggered by murine-derived antibodies remain significant challenges, necessitating the development of novel humanized multitarget CAR-T therapies. Here, we engineered a second-generation 4-1BB-CD3ζ-based CAR construct incorporating humanized CD19 single-chain variable fragments (scFvs) and BAFFR single-variable domains on heavy chains (VHHs), also known as nanobodies. The resultant CAR-T cells, with different constructs, were functionally compared both in vitro and in vivo. We found that the optimal tandem and bicistronic (BI) structures retained respective antigen-binding abilities, and both demonstrated specific activation when stimulated with target cells. At the same time, BI CAR-T cells (BI CARs) exhibited stronger tumour-killing ability and better secretion of interleukin-2 and tumour necrosis factor-alpha than single-target CAR-T cells. Additionally, BI CARs showed less exhaustion phenotype upon repeated antigen stimulation and demonstrated more potent and persistent antitumor effects in mouse xenograft models. Overall, we developed a novel humanized CD19/BAFFR bicistronic CAR (BI CAR) based on a combination of scFv and VHH, which showed potent and sustained antitumor ability both in vitro and in vivo, including against tumours with CD19 or BAFFR deficiencies. | [
0.04759431630373001,
0.0025151711888611317,
0.022138278931379318,
0.04401400312781334,
-0.05217712000012398,
-0.030337199568748474,
-0.008437608368694782,
-0.003011939814314246,
0.015013453550636768,
-0.022961752489209175,
-0.006498271133750677,
-0.0077931517735123634,
-0.04554160311818123,
-0.006146206986159086,
0.03501547873020172,
-0.008491313084959984,
0.026804622262716293,
-0.006713089998811483,
0.009810062125325203,
0.012041792273521423,
0.01365293376147747,
0.011892612092196941,
-0.01146894134581089,
0.0028732025530189276,
-0.007178531028330326,
-0.025109941139817238,
-0.00010983361426042393,
0.007106924895197153,
-0.011510712094604969,
-0.06158141419291496,
0.019536584615707397,
-0.028523175045847893,
-0.016648463904857635,
-0.00588365038856864,
0.0030641527846455574,
0.038786742836236954,
-0.0008831443265080452,
-0.014189980924129486,
0.007990068756043911,
0.0031447098590433598,
0.03212735801935196,
0.007351579610258341,
0.0525590218603611,
0.0400279201567173,
-0.06578231602907181,
-0.009177540428936481,
-0.011373466812074184,
-0.01539535354822874,
-0.0007876692689023912,
0.012071628123521805,
-0.045756421983242035,
0.012149201706051826,
-0.060340236872434616,
0.04308312013745308,
-0.029430188238620758,
0.06425471603870392,
-0.036328259855508804,
-0.012638511136174202,
-0.019763337448239326,
0.01588466390967369,
0.007494792342185974,
-0.025658922269940376,
0.02962113730609417,
-0.006122338119894266,
-0.05246354639530182,
0.029430188238620758,
-0.05422983318567276,
-0.014655421487987041,
0.025658922269940376,
-0.013318770565092564,
0.030575888231396675,
0.010669337585568428,
-0.013080082833766937,
0.022341163828969002,
0.050124406814575195,
0.0002890358155127615,
0.0038906086701899767,
0.037497829645872116,
0.015108928084373474,
-0.0228424072265625,
0.013617130927741528,
0.015586303547024727,
0.0027165638748556376,
-0.05604385957121849,
-0.00042329763527959585,
-0.010412748903036118,
0.02460869587957859,
-0.04208063334226608,
-0.0427250899374485,
0.009320752695202827,
0.02823674865067005,
0.010681272484362125,
-0.04606671631336212,
0.04470619559288025,
0.00350572494789958,
-0.00034106228849850595,
-0.02864251844584942,
-0.07647552341222763,
0.022209886461496353,
0.024310337379574776,
0.05279770866036415,
0.008932885713875294,
0.005644963122904301,
0.011075107380747795,
0.04203289374709129,
-0.009810062125325203,
-0.03692498058080673,
0.014130309224128723,
0.02568279206752777,
0.008002003654837608,
0.06110403686761856,
-0.016564922407269478,
0.018056720495224,
0.030480412766337395,
-0.03737848624587059,
-0.0628703236579895,
-0.0016916986787691712,
0.004021886736154556,
-0.02265145815908909,
0.01750773936510086,
0.012853330001235008,
0.010287437587976456,
0.06349091231822968,
-0.024059714749455452,
-0.007262071594595909,
-0.04377531632781029,
0.08955560624599457,
-0.02354653738439083,
-0.04783300682902336,
-0.055280059576034546,
0.03492000326514244,
0.022174082696437836,
0.018546029925346375,
0.006725024431943893,
-0.04800008609890938,
0.020551007241010666,
-0.02981208823621273,
-0.0012374463258311152,
-0.060435712337493896,
-0.005507717374712229,
0.0017260101158171892,
-0.030146250501275063,
0.007822987623512745,
-0.04110201448202133,
-0.04558934271335602,
-0.025802135467529297,
-0.014416733756661415,
-0.009786193259060383,
-0.023283980786800385,
0.031602244824171066,
-0.021923460066318512,
0.04117361828684807,
0.04425268992781639,
-0.02804579958319664,
-0.02385682985186577,
-0.03260473161935806,
-0.02795032411813736,
0.03900156170129776,
-0.013056214898824692,
-0.05986286327242851,
-0.002922432031482458,
-0.002870219061151147,
-0.04754658043384552,
-0.03031333163380623,
0.033273059874773026,
-0.007530595175921917,
0.006540041416883469,
0.034251678735017776,
-0.0756162479519844,
-0.017078101634979248,
-0.016732003539800644,
-0.009804095141589642,
-0.07800312340259552,
-0.0245609600096941,
-0.0449448861181736,
0.019214356318116188,
0.03482452780008316,
-0.03620891645550728,
-0.03625665232539177,
-0.02623177319765091,
0.010209864005446434,
0.007017416879534721,
0.04635314270853996,
-0.014643487520515919,
-0.03217509388923645,
0.009159638546407223,
-0.04611445590853691,
0.008771771565079689,
-0.0034788725897669792,
-0.02966887503862381,
-0.012531101703643799,
0.032103490084409714,
0.05585290864109993,
0.017424197867512703,
0.04072011262178421,
-0.030886182561516762,
0.031315818428993225,
0.007375448476523161,
-0.0168155450373888,
-0.019106946885585785,
0.02795032411813736,
-0.03625665232539177,
-0.012483363971114159,
-0.013688736595213413,
-0.03434715420007706,
0.0010129307629540563,
-0.015001518651843071,
0.018032852560281754,
-0.04215224087238312,
-0.0038846414536237717,
0.03890608623623848,
0.006993548013269901,
0.018032852560281754,
0.03246152028441429,
-0.03978922963142395,
-0.032986633479595184,
-0.0032849388662725687,
0.06411150097846985,
-0.005054210778325796,
0.01787770539522171,
-0.019166618585586548,
-0.015944335609674454,
-0.013306836597621441,
-0.0007373210974037647,
-0.04248640313744545,
0.005143718793988228,
0.003010448068380356,
-0.03998018056154251,
-0.00900449138134718,
-0.01385581772774458,
0.0035415280144661665,
0.011994054540991783,
0.01782996766269207,
-0.010633534751832485,
-0.02818901091814041,
0.016147218644618988,
0.01014422532171011,
0.01987074688076973,
0.050219882279634476,
-0.0245609600096941,
-0.009947307407855988,
0.03883448243141174,
0.05127010866999626,
-0.002324220957234502,
-0.009243179112672806,
-0.001808058936148882,
-0.013593262061476707,
-0.05933775007724762,
0.010597731918096542,
-0.013438114896416664,
0.022341163828969002,
-0.0203839261084795,
-0.013987096026539803,
0.008527115918695927,
0.00844954326748848,
0.037593305110931396,
0.02001396007835865,
0.0027538586873561144,
0.014452537521719933,
-0.013796146027743816,
-0.03635212779045105,
0.00597912585362792,
-0.017806097865104675,
-0.018999537453055382,
-0.08110606670379639,
0.015956269577145576,
0.0074291531927883625,
0.031029393896460533,
0.027186524122953415,
0.0005474897916428745,
0.005337652750313282,
0.026733016595244408,
0.037593305110931396,
-0.013760343194007874,
-0.02981208823621273,
0.020002024248242378,
-0.018355080857872963,
0.021517692133784294,
-0.008539050817489624,
0.020025894045829773,
0.0026613674126565456,
0.027043310925364494,
0.011624088510870934,
-0.02534862793982029,
-0.016660397872328758,
0.002106418600305915,
0.014715094119310379,
-0.02353460155427456,
0.02182798646390438,
-0.03687724098563194,
0.017770295962691307,
0.009308818727731705,
-0.05222485959529877,
-0.018689243122935295,
-0.017985114827752113,
0.01615915447473526,
-0.020324252545833588,
-0.019942352548241615,
-0.023809093981981277,
0.004827457945793867,
-0.01885632425546646,
0.009637014009058475,
0.007679775357246399,
-0.0017200428992509842,
0.01884439028799534,
0.009631047025322914,
-0.03410846367478371,
-0.010961730033159256,
0.01802091673016548,
0.034752920269966125,
0.030981656163930893,
-0.03513482213020325,
-0.017054231837391853,
-0.017030363902449608,
-0.0009398326510563493,
-0.022949818521738052,
0.0017782229697331786,
-0.060483451932668686,
0.007435120176523924,
-0.02780711092054844,
-0.005328701809048653,
0.021183529868721962,
-0.040696244686841965,
0.01397516205906868,
0.0035474952310323715,
-0.014798634685575962,
-0.008974655531346798,
-0.027735505253076553,
0.005612143315374851,
-0.03589862212538719,
0.029215367510914803,
-0.018164129927754402,
0.05217712000012398,
-0.028021929785609245,
-0.015228272415697575,
-0.033368535339832306,
-0.05069725587964058,
-0.014846371486783028,
0.006011945195496082,
0.015717580914497375,
-0.008556952700018883,
0.024728041142225266,
-0.04699759930372238,
0.02145802043378353,
0.02104031667113304,
0.01432125922292471,
0.035683803260326385,
0.013891621492803097,
-0.010997533798217773,
0.017543543130159378,
0.02618403546512127,
-0.0009502752218395472,
0.01969173178076744,
-0.008234724402427673,
-0.010561928153038025,
0.015132796950638294,
-0.009559440426528454,
0.025658922269940376,
0.0010345617774873972,
0.017567411065101624,
0.013736474327743053,
0.008843377232551575,
-0.019190486520528793,
0.025849873200058937,
0.07160629332065582,
0.026207903400063515,
0.02182798646390438,
0.03838097304105759,
-0.026064692065119743,
-0.02544410340487957,
-0.03924024850130081,
0.00175286247394979,
-0.01889212802052498,
0.01768675446510315,
-0.02229342609643936,
-0.014727028086781502,
0.029692742973566055,
0.015705646947026253,
0.017101969569921494,
-0.02094484120607376,
0.044276557862758636,
-0.03692498058080673,
-0.01713777333498001,
-0.03790359944105148,
-0.006462468300014734,
0.01810445822775364,
0.0324137844145298,
-0.0042367056012153625,
-0.07346805930137634,
0.05036309361457825,
0.007059187162667513,
-0.01578918844461441,
0.008019904606044292,
-0.014762830920517445,
-0.015443091280758381,
0.036662422120571136,
0.0022436638828366995,
0.07265651971101761,
0.041770339012145996,
0.04444364085793495,
-0.014882175251841545,
-0.02354653738439083,
-0.021279003471136093,
-0.04415721446275711,
0.01936950348317623,
0.012202906422317028,
0.03594636172056198,
0.01930983178317547,
0.033225320279598236,
0.007948298938572407,
-0.010042782872915268,
0.003544511506333947,
0.042605746537446976,
0.0029358582105487585,
0.02191152609884739,
-0.007077089045196772,
-0.046830516308546066,
0.0677872896194458,
-0.00006587219831999391,
0.04062463715672493,
0.012011956423521042,
-0.04057690128684044,
0.014786699786782265,
-0.03274794667959213,
0.0027836947701871395,
-0.0008189969812519848,
0.025062203407287598,
0.016743939369916916,
0.010961730033159256,
-0.044968754053115845,
-0.01728098653256893,
0.06721444427967072,
0.003977132961153984,
-0.016135284677147865,
-0.01991848461329937,
0.027377473190426826,
-0.040839456021785736,
0.0023465980775654316,
-0.04881162568926811,
0.06931489706039429,
-0.005806077271699905,
0.008676296100020409,
0.0030223822686821222,
-0.03496773913502693,
0.005057194735854864,
0.014941846951842308,
-0.010388880036771297,
0.016863282769918442,
-0.03694884851574898,
-0.014404799789190292,
-0.030384937301278114,
-0.01723324880003929,
-0.021434150636196136,
0.031148739159107208,
-0.05294091999530792,
0.004902047570794821,
0.06296580284833908,
-0.06563910096883774,
-0.007387382909655571,
0.0036429702304303646,
0.05127010866999626,
-0.05580517277121544,
0.032294437289237976,
-0.03835710510611534,
-0.025730527937412262,
0.05112689360976219,
0.016505250707268715,
-0.010788681916892529,
0.005471914540976286,
-0.04387079179286957,
-0.01395129319280386,
0.01012035645544529,
-0.026900097727775574,
0.04726015403866768,
-0.01746000163257122,
0.036566946655511856,
0.03883448243141174,
0.013306836597621441,
0.043942395597696304,
0.029406318441033363,
-0.03351174667477608,
-0.008574853651225567,
-0.012543035671114922,
-0.024310337379574776,
0.033082108944654465,
0.02182798646390438,
-0.0010300864232704043,
-0.001235208590514958,
-0.000258453976130113,
0.027998061850667,
0.026756886392831802,
-0.016732003539800644,
0.03487226739525795,
-0.010597731918096542,
0.012686248868703842,
-0.021422216668725014,
0.011451040394604206,
-0.010221798904240131,
-0.027329735457897186,
0.03274794667959213,
0.007655906490981579,
0.04126909375190735,
-0.017197445034980774,
0.029692742973566055,
0.034156203269958496,
0.029000548645853996,
0.0272581297904253,
0.04551773518323898,
-0.026709148660302162,
0.020133303478360176,
-0.00028008504887111485,
-0.045708686113357544,
0.03351174667477608,
-0.01574145071208477,
-0.03384590893983841,
-0.016934888437390327,
-0.018927929922938347,
-0.008813541382551193,
-0.015037322416901588,
-0.005868732463568449,
-0.017495805397629738,
-0.030050775036215782,
-0.012710117734968662,
0.011057205498218536,
0.014213849790394306,
-0.020956775173544884,
-0.017209379002451897,
-0.06110403686761856,
-0.04940834268927574,
-0.039956312626600266,
0.02089710347354412,
-0.00039681821363046765,
0.009613145142793655,
0.01112284418195486,
-0.021147726103663445,
-0.034012991935014725,
-0.018677309155464172,
0.047761399298906326,
-0.0049796211533248425,
-0.02795032411813736,
0.012340151704847813,
-0.026613673195242882,
0.02608856000006199,
0.0016648463206365705,
-0.0035922492388635874,
0.030766837298870087,
0.00020213860261719674,
-0.02423873171210289,
0.01936950348317623,
-0.007626070640981197,
0.024871252477169037,
-0.024083584547042847,
0.004633523989468813,
-0.010687239468097687,
-0.002286926144734025,
-0.053179606795310974,
0.013915490359067917,
-0.026733016595244408,
-0.005352570675313473,
-0.01109897531569004,
-0.00041024439269676805,
-0.02888120524585247,
0.0019423207268118858,
-0.0311964750289917,
-0.033368535339832306,
0.008640493266284466,
-0.0028165143448859453,
-0.017627082765102386,
-0.044825538992881775,
0.03506321460008621,
-0.0334162712097168,
0.0014507733285427094,
0.025324760004878044,
-0.03212735801935196,
0.0244296807795763,
0.029430188238620758,
-0.02647045999765396,
0.010758846066892147,
-0.01262657716870308,
0.013378443196415901,
-0.03055201843380928,
-0.03580314666032791,
-0.01592046581208706,
0.034657448530197144,
-0.010717075318098068,
0.026542067527770996,
-0.03802294284105301,
-0.041627127677202225,
-0.016397841274738312,
0.01927402801811695,
0.011689728125929832,
-0.0071964324451982975,
0.032795682549476624,
0.026398854330182076,
-0.031554508954286575,
0.027520686388015747,
0.008043773472309113,
0.0245609600096941,
-0.046400878578424454,
-0.0069577451795339584,
0.0060447645373642445,
-0.03453810140490532,
-0.025563446804881096,
-0.03687724098563194,
-0.045111965388059616,
0.0051377518102526665,
0.011242188513278961,
-0.020181041210889816,
-0.026303378865122795,
0.002358532277867198,
0.04926513135433197,
0.056759923696517944,
0.004639491438865662,
0.006474402733147144,
-0.030337199568748474,
0.008676296100020409,
-0.032198965549468994,
-0.019930418580770493,
-0.005474898032844067,
-0.027830980718135834,
-0.02711491659283638,
-0.01583692617714405,
-0.01856989972293377,
0.025658922269940376,
-0.006921941880136728,
-0.02604082226753235,
-0.007071121595799923,
-0.008061675354838371,
0.022997554391622543,
-0.005104932002723217,
-0.006557943299412727,
-0.020694218575954437,
-0.02266339212656021,
0.03083844482898712,
-0.007906528189778328,
-0.04888322949409485,
0.04009952396154404,
0.017531607300043106,
-0.0077334800735116005,
0.0041531650349497795,
-0.009249146096408367,
0.0070532201789319515,
0.014082571491599083,
-0.055327799171209335,
0.03301050141453743,
-0.02981208823621273,
-0.026446592062711716,
0.009058196097612381,
-0.001667829928919673,
-0.020348122343420982,
-0.04685438424348831,
-0.021004512906074524,
0.023295914754271507,
0.008747902698814869,
0.02330784872174263,
-0.016421711072325706,
-0.0018826487939804792,
-0.0023615160025656223,
0.04888322949409485,
0.04979024454951286,
-0.022579852491617203,
0.03346400707960129,
-0.010884156450629234,
-0.04165099561214447,
-0.004913982003927231,
0.009177540428936481,
-0.009816030040383339,
0.008861279115080833,
0.007614136207848787,
0.01741226390004158,
0.1021583154797554,
-0.004209853243082762,
-0.015765318647027016,
-0.017841901630163193,
-0.014524143189191818,
0.021565429866313934,
0.011087041348218918,
-0.010150192305445671,
-0.023093029856681824,
0.02627951093018055,
-0.004150181543081999,
0.03515869006514549,
-0.019488846883177757,
-0.09442483633756638,
0.027926454320549965,
0.010287437587976456,
-0.005543520674109459,
0.007906528189778328,
0.012017923407256603,
-0.032198965549468994,
-0.016099482774734497,
0.005871716421097517,
-0.04699759930372238,
-0.02047939971089363,
0.019381437450647354,
-0.005677782464772463,
0.009129802696406841,
0.008527115918695927,
-0.03764104098081589,
-0.029191499575972557,
0.017937377095222473,
0.010633534751832485,
0.030289463698863983,
-0.017352592200040817,
0.02181605063378811,
-0.01114671304821968,
-0.0029642023146152496,
0.0006455755210481584,
0.0044455574825406075,
0.03859579190611839,
-0.007596234325319529,
-0.016218826174736023,
-0.027377473190426826,
-0.03964601829648018,
0.003595232730731368,
-0.007900561206042767,
-0.0039234282448887825,
0.05823978781700134,
0.007083056028932333,
0.014452537521719933,
-0.006023879628628492,
0.010717075318098068,
-0.029740480706095695,
-0.02568279206752777,
0.05604385957121849,
0.013318770565092564,
-0.018498292192816734,
0.03816615417599678,
-0.0051467022858560085,
-0.016839412972331047,
0.0013299377169460058,
-0.023439127951860428,
-0.01913081482052803,
0.008097478188574314,
-0.016373973339796066,
0.0230810958892107,
-0.004660376347601414,
-0.03697271645069122,
-0.01611141674220562,
-0.01675587333738804,
0.04105427488684654,
-0.031363558024168015,
-0.018915995955467224,
0.001505969907157123,
-0.03305824100971222,
0.01583692617714405,
0.0331537164747715,
-0.001679764362052083,
-0.00002463797318341676,
-0.028332224115729332,
-0.009887635707855225,
0.008920950815081596,
-0.005722536239773035,
0.0017558460822328925,
-0.009046262130141258,
-0.0162068922072649,
-0.002348089823499322,
0.012781723402440548,
-0.020885169506072998,
-0.030480412766337395,
-0.026947835460305214,
-0.0014291423140093684,
-0.014309324324131012,
-0.00416808295994997,
-0.029048286378383636,
-0.010138258337974548,
0.014917978085577488,
0.010776747018098831,
-0.0015544532798230648,
0.04105427488684654,
-0.013223296031355858,
-0.03974149376153946,
-0.016171088442206383,
-0.004057690035551786,
0.011361531913280487,
0.022508244961500168,
-0.015132796950638294,
0.006754860281944275,
-0.011552481912076473,
0.011988087557256222,
0.002248139353469014,
0.0173167884349823,
0.005749388597905636,
0.01941724121570587,
-0.0010643977439031005,
0.0016648463206365705,
-0.014536078087985516,
0.02232922986149788,
-0.032103490084409714,
-0.01889212802052498,
-0.012805592268705368,
0.022639524191617966,
-0.05738051235675812,
-0.009249146096408367,
0.005128800868988037,
0.027043310925364494,
0.030575888231396675,
-0.09557053446769714,
-0.017627082765102386,
0.0024913023225963116,
0.006480369716882706,
-0.020133303478360176,
0.018832456320524216,
0.0017782229697331786,
-0.02279467135667801,
-0.03597022965550423,
0.009654915891587734,
-0.010848353616893291,
-0.011952283792197704,
0.009738456457853317,
-0.012566904537379742,
-0.017006495967507362,
-0.00590751925483346,
-0.022866277024149895,
-0.0633477047085762,
-0.010162126272916794,
0.027568424120545387,
-0.0031834966503083706,
0.021302873268723488,
-0.01541922241449356,
0.050315357744693756,
-0.021648969501256943,
0.014118374325335026,
-0.030074644833803177,
0.02642272226512432,
-0.049981195479631424,
-0.03153063729405403,
0.02423873171210289,
0.018068654462695122,
-0.02062261290848255,
0.030528150498867035,
0.006158141419291496,
-0.03503934666514397,
0.019846878945827484,
0.003168578492477536,
0.006921941880136728,
0.021338675171136856,
0.005131784360855818,
-0.002701645949855447,
0.015252141281962395,
-0.0026091544423252344,
-0.02604082226753235,
-0.0005292152636684477,
-0.010693206451833248,
0.015311812981963158,
-0.003639986738562584,
-0.02015717141330242,
0.019106946885585785,
-0.031315818428993225,
-0.03370269760489464,
0.02242470532655716,
-0.016839412972331047,
-0.034896135330200195,
-0.00977425929158926,
0.009440097026526928,
0.015550500713288784,
0.04160325601696968,
-0.01630236580967903,
0.03861966356635094,
0.03207961842417717,
-0.006713089998811483,
0.0075842998921871185,
-0.023104963824152946,
-0.03458584100008011,
0.02489512227475643,
-0.025420235469937325,
0.0030701200012117624,
-0.009631047025322914,
0.02740134298801422,
-0.03503934666514397,
0.010323240421712399,
0.02525315433740616,
-0.00017314178694505244,
-0.01893986575305462,
-0.008216822519898415,
-0.001437347149476409,
0.0010815534042194486,
0.005746405106037855,
-0.037855859845876694,
-0.007274006027728319,
-0.004087525885552168,
-0.0346335768699646,
-0.015001518651843071,
0.015681779012084007,
0.02613629773259163,
0.024966727942228317,
0.005489815957844257,
-0.03284342214465141,
-0.0066653527319431305,
-0.011868743225932121,
0.004275492392480373,
-0.008771771565079689,
-0.003735461737960577,
-0.04620992764830589,
0.00014852712047286332,
-0.017483869567513466,
-0.009028360247612,
0.04449137672781944,
-0.026733016595244408,
-0.004362016916275024,
-0.03895382583141327,
-0.049981195479631424,
-0.022209886461496353,
0.036232784390449524,
-0.01633816957473755,
-0.020360056310892105,
-0.010138258337974548,
0.03654307872056961,
0.011254122480750084,
0.025706660002470016,
-0.0008838901994749904,
0.006116371136158705,
0.017627082765102386,
0.041579388082027435,
-0.016493316739797592,
-0.0007884151418693364,
0.014237718656659126,
0.053656984120607376,
0.013115886598825455,
-0.0009361031115986407,
-0.018534095957875252,
0.008443575352430344,
0.02024071291089058,
0.025038335472345352,
0.022818539291620255,
-0.00935655552893877,
-0.01578918844461441,
-0.02340332418680191,
0.023713618516921997,
-0.005567389540374279,
-0.03227056935429573,
-0.0039860839024186134,
0.038882218301296234,
0.005552471615374088,
0.014094505459070206,
0.006945810746401548,
0.03064749389886856,
-0.010370978154242039,
-0.006480369716882706,
0.0003065644414164126,
-0.014500274322926998,
0.028570910915732384,
-0.008616624400019646,
-0.022436639294028282,
0.01625462807714939,
-0.01262657716870308,
0.023940371349453926,
-0.030910050496459007,
0.05752372369170189,
0.04931286722421646,
0.03589862212538719,
0.0010092011652886868,
0.0324137844145298,
0.020312318578362465,
-0.021648969501256943,
-0.02396423928439617,
0.046544093638658524,
-0.048262644559144974,
0.0540388822555542,
0.00010657030361471698,
-0.04282056540250778,
0.024537090212106705,
-0.003863756312057376,
-0.019572386518120766,
-0.006832433864474297,
0.011552481912076473,
0.04057690128684044,
0.0040069688111543655,
-0.08630945533514023,
0.07303842157125473,
0.02108805440366268,
-0.04551773518323898,
0.017030363902449608,
0.04017113149166107,
0.0029701695311814547,
0.011260089464485645,
0.03422781080007553,
-0.009487833827733994,
-0.030337199568748474,
-0.000019183587937732227,
0.008998524397611618,
0.01429739035665989,
-0.010311306454241276,
-0.0028851369861513376,
-0.016457512974739075,
0.05914679914712906,
0.0058269621804356575,
-0.013473917730152607,
-0.019059209153056145,
0.01895179972052574,
0.04401400312781334,
0.03747396171092987,
-0.00014572999498341233,
-0.042223844677209854,
0.019214356318116188,
-0.05475494638085365,
-0.04979024454951286,
-0.058430735021829605,
0.010812550783157349,
0.012757854536175728,
-0.028427699580788612,
-0.017113905400037766,
0.004690212197601795,
0.004693196155130863,
-0.032055750489234924,
0.020264580845832825,
0.048405855894088745,
-0.002279466949403286,
0.036566946655511856,
-0.034896135330200195,
0.027520686388015747,
0.02141028270125389,
0.00039644527714699507,
0.027186524122953415,
-0.006510205566883087,
-0.022460507228970528,
-0.013366508297622204,
-0.02001396007835865,
-0.018164129927754402,
0.0014224292244762182,
0.0052928985096514225,
-0.016194956377148628,
-0.01072304230183363,
0.03850031644105911,
0.007757348474115133,
-0.01014422532171011,
0.015001518651843071,
-0.029955299571156502,
0.03320145234465599,
0.013461983762681484,
-0.005128800868988037,
-0.005403291899710894,
-0.012960739433765411,
-0.013438114896416664,
-0.023486865684390068,
-0.013485852628946304,
-0.013366508297622204,
0.06005381420254707,
0.009267047978937626,
-0.020932907238602638,
-0.024680303409695625,
-0.023606209084391594,
0.000932373630348593,
0.029310842975974083,
-0.0415077842772007,
-0.004409754183143377,
-0.012722051702439785,
0.01121235266327858,
0.009213343262672424,
0.022508244961500168,
0.020455531775951385,
0.03594636172056198,
-0.018736980855464935,
0.019262094050645828,
0.027520686388015747,
0.028809599578380585,
0.0026867277920246124,
-0.004654409363865852,
-0.012507232837378979,
0.010860288515686989,
0.010979631915688515,
0.003550478722900152,
-0.008157150819897652,
0.01193438284099102,
-0.012095496989786625,
-0.0007574603660032153,
0.03133969008922577,
0.027783242985606194,
0.030003037303686142,
0.02024071291089058,
0.007142727728933096,
-0.008741934783756733,
-0.014703159220516682,
0.007643972057849169,
-0.007894594222307205,
-0.004033821169286966,
0.0014276504516601562,
0.007715578190982342,
0.003702642163261771,
-0.04730789363384247,
0.012423692271113396,
0.005498766899108887,
0.0034162169322371483,
-0.015025387518107891,
-0.006080567836761475,
0.019560452550649643,
-0.008533083833754063,
-0.0034221841488033533,
-0.005230243317782879,
-0.014440602622926235,
-0.017806097865104675,
-0.02043166197836399,
-0.014822503551840782,
-0.012722051702439785,
-0.011594252660870552,
-0.003690707730129361,
-0.00315664429217577,
-0.0138796865940094,
0.03597022965550423,
-0.008676296100020409,
-0.027640029788017273,
0.032533127814531326,
-0.01112284418195486,
-0.001858780044130981,
-0.04535065218806267,
0.03776038810610771,
0.0071248263120651245,
-0.04950381815433502,
0.019799141213297844,
0.006623582448810339,
-0.00946993287652731,
0.01532374694943428,
0.019524650648236275,
-0.016779741272330284,
0.013068148866295815,
0.014058702625334263,
-0.014524143189191818,
-0.016612660139799118,
0.012877198867499828,
0.003759330604225397,
-0.004806572571396828,
-0.036113440990448,
-0.018116392195224762,
0.008694197982549667,
-0.016564922407269478,
-0.004185984842479229,
-0.017436133697628975,
0.01635010354220867,
-0.0006698172073811293,
0.026733016595244408,
0.015443091280758381,
-0.02888120524585247,
-0.007542529609054327,
-0.02322430908679962,
-0.003595232730731368,
0.025229284539818764,
0.01930983178317547,
0.003404282731935382,
0.010162126272916794,
0.02316463738679886,
-0.003499757731333375,
0.036375999450683594,
-0.0075126937590539455,
-0.001667829928919673,
0.0011747907847166061,
-0.0353735089302063,
-0.025467973202466965,
0.05618707463145256,
-0.02043166197836399,
-0.02400004304945469,
0.03570767119526863,
0.002691203262656927,
-0.02539636567234993,
0.008688230067491531,
0.013915490359067917,
0.006366993300616741,
-0.019011471420526505,
0.0015932400710880756,
0.018641505390405655,
0.037163667380809784,
-0.015061190351843834,
-0.00007072053995216265,
0.029645007103681564,
-0.021135792136192322,
-0.009893602691590786,
0.005489815957844257,
0.01667233183979988,
0.008700164966285229,
0.01216113567352295,
-0.004305328708142042,
-0.011110910214483738,
-0.006534074433147907,
-0.010561928153038025,
0.02957339957356453,
0.019834943115711212,
0.011779235675930977,
0.032891158014535904,
-0.006546008866280317,
-0.0011650940869003534,
0.0018468457274138927,
-0.006784696597605944,
-0.004293394275009632,
-0.021517692133784294,
-0.0589558482170105,
-0.0353735089302063,
0.02056294120848179,
-0.003076086984947324,
0.0028567928820848465,
-0.006933876313269138,
0.013987096026539803,
0.015490828081965446,
-0.025515709072351456,
-0.016552988439798355,
0.006283452268689871,
0.03045654483139515,
-0.004326213616877794,
-0.012805592268705368,
-0.04800008609890938,
-0.0019348617643117905,
0.030074644833803177,
-0.015359550714492798,
0.005982109345495701,
0.02098064497113228,
0.0010099471546709538,
0.013473917730152607,
0.007381415460258722,
-0.0038100515957921743,
0.006993548013269901,
-0.0035295935813337564,
-0.05141332000494003,
-0.01436899695545435,
-0.02451322227716446,
-0.008115380071103573,
-0.002151172375306487,
-0.010687239468097687,
-0.03756943717598915,
-0.006271517835557461,
-0.0033744466491043568,
-0.0033267091494053602,
0.0029925464186817408,
-0.010806583799421787,
0.013748408295214176,
0.0041650994680821896,
0.01434512808918953,
0.002246647607535124,
-0.04847746342420578,
0.0434650219976902,
-0.0051496862433850765,
0.02289014495909214,
-0.000009970570317818783,
0.007817020639777184,
-0.014607683755457401,
0.012984608300030231,
-0.007930397056043148,
0.013796146027743816,
-0.01713777333498001,
0.013664867728948593,
-0.007142727728933096,
0.017949311062693596,
0.04370370879769325,
0.049837980419397354,
0.01680361106991768,
-0.015717580914497375,
-0.006862270180135965,
0.0001659625122556463,
0.0336310900747776,
0.012757854536175728,
0.009398326277732849,
0.02563505433499813,
-0.04215224087238312,
-0.017627082765102386,
-0.024584827944636345,
0.02632724866271019,
-0.04449137672781944,
-0.051747482270002365,
0.018880194053053856,
0.02947792410850525,
-0.014082571491599083,
-0.0032759879250079393,
-0.002880661515519023,
0.03601796552538872,
0.005391357466578484,
0.002031828509643674,
0.0009375949157401919,
-0.007608168758451939,
-0.0037652975879609585,
0.014619618654251099,
0.012155168689787388,
-0.00554650416597724,
0.02479964680969715,
0.013784212060272694,
0.025109941139817238,
-0.02047939971089363,
0.008455510251224041,
0.02354653738439083,
0.008413739502429962,
-0.029191499575972557,
-0.033082108944654465,
0.00554948765784502,
-0.005430144257843494,
0.0024331221356987953,
0.011409269645810127,
0.017662886530160904,
0.0098219970241189,
-0.031124869361519814,
0.0034281513653695583,
0.00793636403977871,
-0.018999537453055382,
-0.0392879880964756,
-0.011230253614485264,
0.004985588137060404,
-0.009738456457853317,
-0.021434150636196136,
0.006005978211760521,
0.0062894197180867195,
0.0077334800735116005,
0.00018274523608852178,
-0.007930397056043148,
-0.01689908653497696,
0.0032879223581403494,
-0.03079070709645748,
0.011027369648218155,
0.0270194411277771,
-0.024942860007286072,
-0.02024071291089058,
0.012399823404848576,
0.02888120524585247,
-0.040051788091659546,
0.0011002009268850088,
-0.018701177090406418,
-0.0235823392868042,
0.04425268992781639,
-0.02433420531451702,
0.003851821878924966,
-0.003082054201513529,
0.014416733756661415,
0.007781217340379953,
0.006396829150617123,
0.0209925789386034,
0.02599308453500271,
0.0021496806293725967,
-0.0018781734397634864,
-0.030814575031399727,
0.01404676865786314,
0.04618605971336365,
-0.009977144189178944,
0.02558731660246849,
0.02966887503862381,
-0.019095012918114662,
0.006468435283750296,
0.006217813119292259,
-0.032151225954294205,
0.04795235022902489,
-0.005904535762965679,
0.008831443265080452,
-0.010263568721711636,
-0.03398912027478218,
-0.001230733236297965,
-0.008562919683754444,
0.0412452258169651,
0.01837894879281521,
0.00350572494789958,
0.03857192397117615,
0.018975667655467987,
-0.01624269410967827,
-0.017543543130159378,
0.03857192397117615,
0.00833616591989994,
-0.0027672848664224148,
-0.009690718725323677,
0.03420393913984299,
-0.03532577306032181,
-0.04012339562177658,
-0.023737486451864243,
0.016552988439798355,
-0.012996542267501354,
-0.024071648716926575,
0.023021424189209938,
0.007178531028330326,
0.014858306385576725,
0.02525315433740616,
-0.010752879083156586,
-0.002803088165819645,
-0.03255699574947357,
0.003463954431936145,
-0.02266339212656021,
-0.010675305500626564,
0.0012836919631808996,
-0.014058702625334263,
-0.003869723528623581,
0.015992073342204094,
0.006468435283750296,
0.008485346101224422,
0.014106440357863903,
0.006528107449412346,
0.0008548001642338932,
0.01114671304821968,
-0.012913001701235771,
-0.002752366941422224,
-0.02098064497113228,
0.01583692617714405,
-0.014476406387984753,
-0.04883549362421036,
-0.05556648597121239,
0.02780711092054844,
-0.00010479879711056128,
0.007614136207848787,
-0.0427250899374485,
0.004591753706336021,
0.009195441380143166,
-0.011498777195811272,
0.016839412972331047,
0.04702146723866463,
-0.0002174295368604362,
-0.004472409840673208,
-0.03952667489647865,
-0.01049032248556614,
-0.03606570512056351,
0.056664448231458664,
-0.015896597877144814,
0.01709003560245037,
0.007083056028932333,
-0.027234261855483055,
-0.012447561137378216,
-0.017949311062693596,
-0.034514233469963074,
0.00043448610813356936,
-0.03797520697116852,
0.015108928084373474,
-0.0018557964358478785,
-0.016934888437390327,
0.008097478188574314,
0.012053726240992546,
-0.036614686250686646,
-0.0007209113100543618,
0.004660376347601414,
0.008288429118692875,
0.04652022197842598,
0.04704533517360687,
-0.02229342609643936,
-0.008735967800021172,
0.0066534182988107204,
0.024537090212106705,
-0.004597720690071583,
-0.009589276276528835,
0.03329692780971527,
-0.020718088373541832,
-0.0008667345391586423,
0.011337663047015667,
0.0038965758867561817,
-0.019894614815711975,
0.028451567515730858,
-0.02107612043619156,
0.0035027412232011557,
0.008813541382551193,
-0.021207397803664207,
0.026542067527770996,
-0.01839088276028633,
0.013521655462682247,
0.03286729007959366,
0.024584827944636345,
-0.01718551106750965,
0.020765826106071472,
0.0013299377169460058,
0.00560617633163929,
0.01694682240486145,
0.005176538601517677,
-0.002638990292325616,
0.01954851858317852,
0.00012335303472355008,
-0.0014448062283918262,
0.017209379002451897,
0.024071648716926575,
-0.001972156809642911,
0.034848395735025406,
-0.019071143120527267,
0.013366508297622204,
0.03778425604104996,
-0.023976175114512444,
0.01847442425787449,
0.025014465674757957,
0.014249652624130249,
0.00315664429217577,
0.037402354180812836,
-0.0003602691867854446,
-0.007071121595799923,
-0.021899592131376266,
-0.0429876446723938,
-0.01685134880244732,
-0.017698688432574272,
0.00842567440122366,
0.10540446639060974,
-0.025420235469937325,
-0.0010979631915688515,
0.013175558298826218,
-0.009350588545203209,
-0.006008961703628302,
0.009249146096408367,
0.01847442425787449,
0.015992073342204094,
-0.03246152028441429,
0.03556445986032486,
0.009559440426528454,
0.02544410340487957,
0.01564597524702549,
0.03838097304105759,
-0.0222337543964386,
0.01318749226629734,
0.0058896178379654884,
-0.016230760142207146,
-0.017627082765102386,
-0.006053715478628874,
0.02618403546512127,
-0.017078101634979248,
0.03059975616633892,
-0.019285961985588074,
-0.018641505390405655,
-0.00034106228849850595,
-0.024680303409695625,
-0.005346603225916624,
-0.011254122480750084,
0.011773268692195415,
-0.0051467022858560085,
0.005164604168385267,
-0.017209379002451897,
0.0023451060988008976,
-0.006713089998811483,
-0.034514233469963074,
-0.028666386380791664,
-0.0034967740066349506,
-0.009893602691590786,
0.00005048803359386511,
0.021302873268723488,
-0.006402796134352684,
0.026661410927772522,
0.02730586752295494,
0.0008570378413423896,
-0.014583815820515156,
-0.018832456320524216,
-0.0031745457090437412,
-0.018963733687996864,
0.0049080150201916695,
0.0017319772159680724,
0.02985982596874237,
0.008115380071103573,
-0.025086071342229843,
-0.012352085672318935,
0.018927929922938347,
0.004484344273805618,
-0.007745414040982723,
-0.036805637180805206,
-0.023152701556682587,
0.026303378865122795,
0.019942352548241615,
0.02345106191933155,
0.0316738523542881
] | 2024-07-04 | 1 | 38960449 | [
"BI CAR",
"BI CARs",
"target cells",
"CAR",
"BI CAR-T cells",
"repeated antigen stimulation",
"CD19",
"BI",
"novel humanized multitarget CAR-T therapies",
"humanized CD19 single-chain variable fragments",
"heavy chains",
"tumours",
"a novel humanized CD19/BAFFR bicistronic CAR",
"less exhaustion phenotype",
"BAFFR",
"mouse xenograft models",
"immune responses",
"significant challenges",
"respective antigen-binding abilities",
"single-target CAR-T cells",
"remarkable efficacy",
"stronger tumour-killing ability",
"specific activation",
"advanced B-cell malignancies",
"better secretion",
"potent and sustained antitumor ability",
"Chimeric antigen receptor T cell (CAR-T) therapy",
"different constructs",
"CD19 or BAFFR deficiencies",
"vivo"
] | [
"BAFFR",
"B‐cell malignancies",
"CD19",
"chimeric antigen receptor",
"fully human antibody"
] | 0 | 10.1111/bjh.19631 | [
"Wu",
"Luo",
"Li",
"Zhang",
"Zhang",
"Liu",
"Shao",
"Hong",
"Tan",
"Dong",
"Chen"
] | [
"Department of Hematology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.",
"Iaso Biotherapeutics Co. Ltd., Nanjing, Jiangsu, China.",
"Department of Hematology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.",
"Department of Hematology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.",
"Department of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.",
"Iaso Biotherapeutics Co. Ltd., Nanjing, Jiangsu, China.",
"Iaso Biotherapeutics Co. Ltd., Nanjing, Jiangsu, China.",
"Department of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.",
"Iaso Biotherapeutics Co. Ltd., Nanjing, Jiangsu, China.",
"Department of Hematology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.\nDepartment of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.",
"Department of Hematology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.\nDepartment of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China."
] | [
"38960449"
] | [] | 8.136279 | 5.254185 |
38959896 | 774 | Human plasma cells engineered to secrete bispecifics drive effective in vivo leukemia killing. | Bispecific antibodies are an important tool for the management and treatment of acute leukemias. As a next step toward clinical translation of engineered plasma cells, we describe approaches for secretion of bispecific antibodies by human plasma cells. We show that human plasma cells expressing either fragment crystallizable domain-deficient anti-CD19 × anti-CD3 (blinatumomab) or anti-CD33 × anti-CD3 bispecific antibodies mediate T cell activation and direct T cell killing of B acute lymphoblastic leukemia or acute myeloid leukemia cell lines in vitro. We demonstrate that knockout of the self-expressed antigen, CD19, boosts anti-CD19-bispecific secretion by plasma cells and prevents self-targeting. Plasma cells secreting anti-CD19-bispecific antibodies elicited in vivo control of acute lymphoblastic leukemia patient-derived xenografts in immunodeficient mice co-engrafted with autologous T cells. In these studies, we found that leukemic control elicited by engineered plasma cells was similar to CD19-targeted chimeric antigen receptor-expressing T cells. Finally, the steady-state concentration of anti-CD19 bispecifics in serum 1 month after cell delivery and tumor eradication was comparable with that observed in patients treated with a steady-state infusion of blinatumomab. These findings support further development of ePCs for use as a durable delivery system for the treatment of acute leukemias, and potentially other cancers. | [
0.02652040496468544,
0.017740458250045776,
0.008435745723545551,
0.0379411056637764,
0.006353612057864666,
-0.020719772204756737,
0.021611308678984642,
-0.012221956625580788,
0.020922906696796417,
-0.003080880967900157,
0.02473733015358448,
-0.013993745669722557,
-0.04730788618326187,
0.009062078781425953,
0.051731716841459274,
-0.0057498496025800705,
0.02076491340994835,
0.015562399290502071,
-0.015912242233753204,
0.01844014599919319,
0.0040739853866398335,
0.02435363084077835,
0.011324777267873287,
0.029138589277863503,
-0.027558650821447372,
-0.047217607498168945,
0.021611308678984642,
-0.01760503463447094,
0.0013147349236533046,
-0.027355514466762543,
0.04419315233826637,
-0.034465242177248,
0.0059868404641747475,
-0.027400655671954155,
-0.011578695848584175,
0.054936736822128296,
0.025256453081965446,
0.0033094079699367285,
0.00033573704422451556,
0.002217557281255722,
0.022593127563595772,
-0.01324891671538353,
0.0044210078194737434,
0.021870870143175125,
-0.05850288271903992,
-0.005851416848599911,
-0.05394363030791283,
0.007358001545071602,
0.021475885063409805,
-0.0060432665050029755,
0.011482770554721355,
0.03200504928827286,
-0.03699314221739769,
0.03146335855126381,
0.019895946606993675,
0.017684031277894974,
-0.02097933366894722,
0.030357399955391884,
-0.04471227526664734,
-0.02828090824186802,
0.005476181395351887,
-0.03358498960733414,
0.030763668939471245,
0.026791252195835114,
-0.007358001545071602,
-0.010551735758781433,
-0.06112106889486313,
-0.028371190652251244,
0.0015644216910004616,
-0.0296802818775177,
0.01661192998290062,
-0.018485287204384804,
-0.021261464804410934,
0.024285919964313507,
0.01918497309088707,
0.03247903287410736,
-0.0043222615495324135,
0.058864012360572815,
-0.015020705759525299,
-0.006720383185893297,
0.01724390499293804,
0.0221417173743248,
0.013418196700513363,
-0.03466837480664253,
-0.01978309266269207,
0.018643280491232872,
0.04590851441025734,
0.010337315499782562,
-0.027964919805526733,
0.041687820106744766,
-0.014072742313146591,
-0.024624478071928024,
-0.06089536473155022,
0.04471227526664734,
-0.016092807054519653,
-0.02530159428715706,
-0.0003688875585794449,
-0.048978108912706375,
0.04784958064556122,
0.04983578994870186,
0.04121383652091026,
0.03958875685930252,
-0.004206587560474873,
-0.04766901582479477,
0.05416933819651604,
-0.056697238236665726,
-0.011527911759912968,
0.015314122661948204,
0.04062700271606445,
-0.011849542148411274,
0.07470854371786118,
0.0007688095793128014,
-0.02965771220624447,
0.030425110831856728,
-0.010664587840437889,
-0.08008033782243729,
-0.03803138807415962,
-0.0004697497352026403,
-0.02233356609940529,
0.03457809239625931,
0.019625099375844002,
0.0025137958582490683,
0.03859565407037735,
-0.03065081685781479,
0.002667557680979371,
-0.0324338898062706,
0.10228976607322693,
-0.023902220651507378,
-0.03839251771569252,
-0.07669475674629211,
0.03780568391084671,
-0.014095312915742397,
-0.01680378057062626,
-0.03202762082219124,
-0.06604144722223282,
0.02140817418694496,
0.005479002837091684,
-0.023902220651507378,
-0.050964318215847015,
-0.023834507912397385,
0.024285919964313507,
0.02435363084077835,
-0.008667093701660633,
-0.03006398305296898,
-0.059089720249176025,
-0.046224500983953476,
0.03498436510562897,
-0.009914116933941841,
-0.023518521338701248,
-0.006195617839694023,
-0.04022073373198509,
0.048571839928627014,
0.0624753013253212,
-0.034736089408397675,
-0.028800031170248985,
-0.03663201257586479,
-0.012323523871600628,
0.042861487716436386,
0.01503199152648449,
-0.02990598790347576,
-0.0013492960715666413,
0.02374422550201416,
-0.030605675652623177,
-0.016126662492752075,
-0.043425753712654114,
0.001364813419058919,
0.015494687482714653,
0.003994988743215799,
-0.04313233494758606,
0.02059563435614109,
0.0051263379864394665,
0.007092797663062811,
-0.05561385303735733,
-0.0031203795224428177,
-0.021442029625177383,
0.017232621088624,
0.030425110831856728,
-0.03545834496617317,
-0.03286273032426834,
-0.04209408909082413,
0.01921883039176464,
0.0003426140174269676,
0.013192490674555302,
-0.01544954627752304,
0.009146718308329582,
0.027265233919024467,
-0.04173295944929123,
0.021701591089367867,
-0.006906590424478054,
-0.012729794718325138,
-0.004674926865845919,
0.023811938241124153,
0.022288424894213676,
-0.005196870770305395,
-0.0016095628961920738,
0.007871481589972973,
0.012131674215197563,
0.014614435844123363,
0.010517879389226437,
-0.04654048755764961,
0.0411686971783638,
-0.007578064687550068,
-0.024647047743201256,
0.015302837826311588,
-0.0294997189193964,
0.03561633825302124,
0.007019443437457085,
0.029567429795861244,
-0.036496590822935104,
-0.00593605637550354,
0.03478122875094414,
0.00002336405304959044,
0.001708309049718082,
0.010517879389226437,
-0.04198123514652252,
-0.001022728392854333,
-0.03900192305445671,
0.03200504928827286,
0.01800001971423626,
0.016961773857474327,
-0.003348906524479389,
-0.03028968721628189,
-0.027829496189951897,
0.006421323399990797,
-0.03726398944854736,
-0.019918516278266907,
0.0033460850827395916,
-0.040491580963134766,
-0.009812549687922001,
-0.004466149024665356,
-0.005498751997947693,
-0.0095134899020195,
0.008232610300183296,
-0.0306959580630064,
-0.004435114562511444,
-0.022096576169133186,
-0.01513355877250433,
0.0327950194478035,
0.04491540789604187,
-0.036925431340932846,
0.024421343579888344,
0.03268216550350189,
0.02136303298175335,
-0.007572421804070473,
-0.0012195154558867216,
-0.0005695539293810725,
-0.010980576276779175,
-0.0641455203294754,
-0.0005660272436216474,
0.0015785283176228404,
0.012899073772132397,
0.014783714897930622,
-0.0034250819589942694,
-0.010534808039665222,
0.015189984813332558,
0.029522288590669632,
0.0296802818775177,
-0.06134677305817604,
-0.0020087796729058027,
-0.022265855222940445,
-0.028416331857442856,
0.05304080992937088,
-0.043809451162815094,
-0.00697994465008378,
-0.050964318215847015,
0.039859604090452194,
-0.006037624087184668,
0.04744331166148186,
0.04042386636137962,
0.0269266739487648,
0.014614435844123363,
0.02331538498401642,
0.03604517877101898,
-0.045615095645189285,
-0.05439504235982895,
0.010314744897186756,
-0.03008655272424221,
-0.001054468215443194,
-0.02988341823220253,
0.03421696648001671,
-0.01760503463447094,
-0.011042645201086998,
-0.024015072733163834,
-0.042635783553123474,
-0.04477998614311218,
0.012041392736136913,
-0.012684653513133526,
-0.06568032503128052,
-0.004040129948407412,
0.004497183486819267,
0.005010663531720638,
0.014050171710550785,
-0.04604393616318703,
-0.015291552990674973,
-0.002144202822819352,
-0.01778559945523739,
-0.027445796877145767,
-0.02135174721479416,
-0.03918248787522316,
0.04726274684071541,
-0.018643280491232872,
-0.027378086000680923,
0.007329788524657488,
-0.013689043000340462,
0.012899073772132397,
0.024782471358776093,
-0.03387840464711189,
0.0013753933599218726,
0.04035615548491478,
0.017582464963197708,
0.03144078701734543,
-0.014230736531317234,
0.003724141977727413,
-0.03527778014540672,
0.02376679703593254,
-0.022277139127254486,
0.005747028160840273,
-0.03024454601109028,
-0.028777459636330605,
-0.05516244098544121,
-0.026249557733535767,
-0.02255927212536335,
-0.04419315233826637,
-0.022694695740938187,
-0.01120063941925764,
-0.0017111303750425577,
-0.005811918526887894,
-0.001833857735618949,
0.035729192197322845,
-0.04875240474939346,
0.031192509457468987,
-0.008514742366969585,
0.010946719907224178,
-0.034532953053712845,
-0.01995237171649933,
-0.008435745723545551,
0.022841403260827065,
-0.001743575558066368,
0.01067587360739708,
0.03873107582330704,
-0.043245188891887665,
0.047217607498168945,
-0.04137182980775833,
0.015776818618178368,
0.06405524164438248,
-0.010822582058608532,
0.04037872701883316,
0.00931599736213684,
0.0379411056637764,
0.034307245165109634,
0.010365528054535389,
-0.015359263867139816,
0.004240443464368582,
0.001471318188123405,
0.010263960808515549,
0.007295932620763779,
-0.01070408709347248,
-0.0014614436076954007,
0.009891546331346035,
0.004584644455462694,
0.017085911706089973,
-0.027648933231830597,
-0.023247674107551575,
0.00563699658960104,
0.02277369238436222,
0.035932328552007675,
0.006201260723173618,
-0.00568495923653245,
-0.02094547636806965,
-0.01564139686524868,
0.001440988969989121,
0.004006274044513702,
0.009259571321308613,
0.020437639206647873,
-0.04473484307527542,
0.02415049634873867,
0.007628848310559988,
0.012583085335791111,
-0.007341073825955391,
-0.003475865814834833,
0.03870850428938866,
0.00361411040648818,
-0.018507856875658035,
-0.0507386140525341,
-0.05227341130375862,
-0.0004958469071425498,
0.02331538498401642,
-0.025843288749456406,
-0.06874991953372955,
0.015562399290502071,
0.023676514625549316,
-0.0341041125357151,
0.019850805401802063,
-0.05042262375354767,
0.001706898445263505,
0.04340318217873573,
-0.02215300127863884,
0.06256558746099472,
0.051144883036613464,
0.011996251530945301,
-0.025820717215538025,
-0.02376679703593254,
0.02530159428715706,
-0.07543080300092697,
0.00033485537278465927,
-0.0257304348051548,
0.043628886342048645,
0.01740190014243126,
0.02298811264336109,
-0.011578695848584175,
-0.00543668307363987,
0.017966164276003838,
0.02613670565187931,
0.007651418913155794,
0.019331682473421097,
-0.008497814647853374,
-0.04389973357319832,
0.09168160706758499,
-0.0077473437413573265,
0.04480255767703056,
0.01762760430574417,
-0.05714865028858185,
0.04920381307601929,
-0.011702833697199821,
0.0016391867538914084,
-0.011443272233009338,
0.011601266451179981,
0.009124147705733776,
0.0020045475102961063,
-0.019026979804039,
-0.03697057440876961,
0.05615554749965668,
-0.00017068983288481832,
-0.053311657160520554,
-0.04611164703965187,
0.06401009857654572,
-0.024782471358776093,
0.01070408709347248,
-0.016690926626324654,
0.054936736822128296,
-0.029454577714204788,
-0.009220072999596596,
-0.039250198751688004,
-0.03816681355237961,
-0.0211824681609869,
0.001022728392854333,
0.01324891671538353,
0.030583105981349945,
-0.023857079446315765,
0.030334828421473503,
0.028393760323524475,
-0.04893296957015991,
0.01097493339329958,
0.020821338519454002,
-0.03419439494609833,
-0.009637627750635147,
0.04412543773651123,
-0.040446437895298004,
-0.00014150681090541184,
0.004971165210008621,
0.02789720892906189,
-0.034555524587631226,
0.006850163917988539,
-0.015720393508672714,
-0.05723893269896507,
0.036722294986248016,
0.03338185325264931,
-0.016137948259711266,
0.0027268053963780403,
-0.02235613763332367,
0.005617247428745031,
-0.016781209036707878,
0.01581067591905594,
0.04410286992788315,
-0.04685647785663605,
0.04270349442958832,
0.02810034342110157,
0.025188742205500603,
0.05547843128442764,
0.05051290616393089,
0.018936697393655777,
-0.03428467735648155,
-0.012030106969177723,
-0.03496179357171059,
0.049158673733472824,
-0.01324891671538353,
0.018835129216313362,
0.0031880910973995924,
-0.014061457477509975,
0.011279636062681675,
0.006601888220757246,
-0.012808791361749172,
0.03739941492676735,
-0.00901693757623434,
0.026384981349110603,
-0.024466484785079956,
-0.009270856156945229,
-0.03324643149971962,
0.004263014066964388,
0.014174309559166431,
0.006139191798865795,
0.03762511909008026,
0.003676179563626647,
0.022615699097514153,
0.04128154739737511,
-0.00782069843262434,
0.004090913571417332,
0.016973059624433517,
-0.04340318217873573,
0.03816681355237961,
-0.0040288446471095085,
-0.0324338898062706,
0.04295177012681961,
-0.010664587840437889,
-0.04455427825450897,
-0.028010061010718346,
-0.046991899609565735,
-0.008097187615931034,
0.00220486125908792,
0.016578074544668198,
-0.014117883518338203,
-0.0035097217187285423,
0.0031175583135336637,
-0.006946089211851358,
0.00687837740406394,
0.0009564273641444743,
-0.054349903017282486,
-0.06545461714267731,
-0.06116621196269989,
-0.03489408269524574,
0.017311617732048035,
-0.0015291552990674973,
0.006596245337277651,
0.03218561410903931,
-0.01705205626785755,
0.012504088692367077,
-0.0010918506886810064,
0.024421343579888344,
-0.022649554535746574,
-0.02514360100030899,
-0.004418186377733946,
0.004023201763629913,
0.033946119248867035,
-0.019873375073075294,
0.012402521446347237,
-0.03153106942772865,
0.020663345232605934,
-0.027242662385106087,
0.005123516544699669,
0.013598760589957237,
0.022446420043706894,
-0.046991899609565735,
-0.010563020594418049,
-0.004452042281627655,
0.009919759817421436,
-0.01935425214469433,
-0.029341723769903183,
0.000014833969544270076,
0.029183730483055115,
-0.005747028160840273,
-0.025166170671582222,
-0.04229722544550896,
-0.018891556188464165,
-0.037512265145778656,
-0.002515206579118967,
-0.009434493258595467,
0.010546092875301838,
-0.0010791547829285264,
-0.041845813393592834,
0.03577433153986931,
-0.055523570626974106,
0.03227589651942253,
0.0064833927899599075,
-0.047037042677402496,
0.0075385659001767635,
0.0341041125357151,
-0.038302235305309296,
-0.023789366707205772,
-0.02433106116950512,
-0.0005776652251370251,
-0.006426966283470392,
-0.01859813928604126,
-0.02688153274357319,
0.04509597271680832,
-0.0128652174025774,
-0.007589349988847971,
-0.06193361058831215,
-0.005710350815206766,
0.027761785313487053,
-0.0023106609005481005,
0.026836393401026726,
-0.034916650503873825,
0.002953921677544713,
0.02017807774245739,
-0.009310354478657246,
-0.006771167274564505,
0.030537964776158333,
0.018507856875658035,
-0.010867723263800144,
-0.03144078701734543,
0.010912864468991756,
-0.015077131800353527,
-0.05123516544699669,
-0.003952668979763985,
-0.03299815580248833,
0.02372165583074093,
-0.0024404413998126984,
-0.015754248946905136,
-0.01236866507679224,
-0.003664894262328744,
0.02591099962592125,
0.05308594927191734,
-0.038685936480760574,
0.0029849561396986246,
0.0007469443953596056,
0.03358498960733414,
-0.016894062981009483,
0.01701820082962513,
0.02667839825153351,
0.0008005494601093233,
0.0044605061411857605,
0.0016504720551893115,
-0.001151803764514625,
0.0005212388350628316,
0.015607540495693684,
-0.03940819203853607,
-0.03227589651942253,
0.0006104630301706493,
0.016555503010749817,
0.04550224170088768,
-0.0010502362856641412,
-0.003927276935428381,
-0.0002234132552985102,
0.04031101614236832,
0.017503466457128525,
0.011465842835605145,
0.031734202057123184,
-0.017097197473049164,
-0.0008294679573737085,
0.0030498465057462454,
-0.012853932566940784,
0.01743575558066368,
-0.010636375285685062,
-0.04112355411052704,
0.01803387515246868,
-0.029973700642585754,
-0.0324338898062706,
0.01642008125782013,
0.03146335855126381,
-0.041868384927511215,
-0.04875240474939346,
0.014016316272318363,
0.022310996428132057,
0.02036992833018303,
0.027220092713832855,
-0.0399724580347538,
-0.01098621916025877,
-0.02157745324075222,
0.033720411360263824,
0.019263969734311104,
-0.035932328552007675,
0.037489697337150574,
-0.007961764000356197,
-0.0018409111071377993,
-0.009914116933941841,
-0.037895966321229935,
0.007634491194039583,
-0.0026238271966576576,
0.016950488090515137,
-0.01414045412093401,
0.05823203921318054,
-0.016510361805558205,
0.0223787073045969,
-0.020313501358032227,
-0.04019816219806671,
-0.00048597229761071503,
0.003402511589229107,
-0.011257065460085869,
-0.002558936830610037,
0.012594371102750301,
-0.0049344878643751144,
0.012910358607769012,
-0.005278688855469227,
-0.07326402515172958,
-0.01364390179514885,
0.0077473437413573265,
0.002156898844987154,
-0.014783714897930622,
-0.020099081099033356,
-0.02708466909825802,
-0.010139822959899902,
0.005349222104996443,
-0.019139831885695457,
-0.006477749906480312,
-0.0007490603602491319,
-0.02433106116950512,
0.005256118718534708,
-0.010715371929109097,
-0.046021364629268646,
-0.025595011189579964,
0.015212555415928364,
-0.0183724332600832,
0.035526055842638016,
-0.028145484626293182,
0.016194375231862068,
-0.00008384609100176021,
-0.024850184097886086,
-0.0009571326663717628,
0.015178699977695942,
0.017751744017004967,
-0.0019241400295868516,
0.012989355251193047,
-0.013903463259339333,
-0.023428238928318024,
0.012436376884579659,
-0.00989718921482563,
-0.018237009644508362,
0.06879505515098572,
0.018349863588809967,
-0.012470233254134655,
0.011917253956198692,
0.004996557254344225,
-0.028958024457097054,
-0.002115989802405238,
0.06134677305817604,
0.02336052618920803,
-0.023699084296822548,
0.07177437096834183,
-0.007008158136159182,
0.0048780618235468864,
0.00782634038478136,
-0.01165769249200821,
-0.011550482362508774,
-0.004581823013722897,
-0.017097197473049164,
0.023428238928318024,
-0.004152982495725155,
-0.013237631879746914,
-0.001294985762797296,
-0.022457703948020935,
0.01364390179514885,
-0.011804401874542236,
-0.01424202136695385,
0.018744848668575287,
-0.014964279718697071,
-0.002010190160945058,
0.023450808599591255,
0.021893439814448357,
-0.02160002291202545,
-0.03428467735648155,
-0.00928778387606144,
0.006573674734681845,
-0.036722294986248016,
0.01900440827012062,
-0.005493109580129385,
-0.03956618532538414,
-0.014388729818165302,
-0.010664587840437889,
-0.018699707463383675,
-0.021724160760641098,
0.010608161799609661,
-0.003664894262328744,
-0.034736089408397675,
0.01679249480366707,
-0.04568280652165413,
-0.036519162356853485,
0.019117262214422226,
-0.004325082991272211,
-0.0010445936350151896,
-0.0032586241140961647,
-0.017097197473049164,
-0.013689043000340462,
0.006793737877160311,
-0.012831361964344978,
0.03523264080286026,
0.0008379319333471358,
-0.05042262375354767,
-0.008650165982544422,
0.011415059678256512,
0.018552998080849648,
-0.016690926626324654,
-0.004102198872715235,
-0.007837626151740551,
0.01364390179514885,
0.012030106969177723,
-0.0067598819732666016,
0.004268656484782696,
0.008509100414812565,
-0.01177054550498724,
-0.03640630841255188,
0.0005995304090902209,
0.050783753395080566,
-0.03796367719769478,
0.0083172507584095,
-0.0038849571719765663,
0.020245790481567383,
0.030921664088964462,
-0.07940322160720825,
-0.010139822959899902,
-0.02791977860033512,
-0.003628217149525881,
-0.02810034342110157,
-0.008232610300183296,
-0.012030106969177723,
0.018361147493124008,
-0.012357380241155624,
-0.002939815167337656,
0.03006398305296898,
-0.0201667919754982,
0.016927918419241905,
0.02317996136844158,
-0.023653943091630936,
-0.032163042575120926,
-0.04626964405179024,
-0.033765554428100586,
0.01821443997323513,
-0.009716625325381756,
-0.005433861631900072,
0.02927401289343834,
-0.030921664088964462,
0.024692188948392868,
-0.041823241859674454,
0.011279636062681675,
-0.036338597536087036,
0.02015550807118416,
-0.04191352427005768,
-0.050783753395080566,
0.036722294986248016,
0.047985006123781204,
-0.0267461109906435,
-0.0174131840467453,
0.018067730590701103,
-0.05304080992937088,
0.031734202057123184,
0.012142959982156754,
-0.005312544759362936,
0.007036371156573296,
0.0016152055468410254,
0.02157745324075222,
-0.0003008232160937041,
-0.004474612884223461,
-0.011245779693126678,
0.0019156760536134243,
-0.009637627750635147,
0.02094547636806965,
0.02751350961625576,
-0.015912242233753204,
0.01436616014689207,
-0.015776818618178368,
-0.04288405925035477,
0.034713517874479294,
-0.014591865241527557,
-0.041823241859674454,
-0.043832022696733475,
0.00898872409015894,
0.013926033861935139,
0.011127284727990627,
0.007685274817049503,
0.04259064048528671,
0.033156149089336395,
0.0045423246920108795,
-0.022130431607365608,
-0.022288424894213676,
-0.04071728512644768,
0.023247674107551575,
-0.036699727177619934,
-0.020640773698687553,
0.0021893440280109644,
0.023789366707205772,
-0.0038962424732744694,
0.019873375073075294,
0.04371916875243187,
-0.015562399290502071,
-0.015607540495693684,
-0.001994672929868102,
-0.0007892641588114202,
0.004655177239328623,
0.015268982388079166,
0.020685914903879166,
-0.014411300420761108,
0.0162169449031353,
-0.028393760323524475,
-0.016070237383246422,
0.01881255954504013,
0.02929658256471157,
0.005019127856940031,
0.013903463259339333,
-0.0094852764159441,
-0.03915991634130478,
0.01414045412093401,
0.003848280059173703,
-0.008085901848971844,
-0.013531048782169819,
-0.0439223051071167,
-0.03049282357096672,
0.018361147493124008,
0.008012548089027405,
0.025233883410692215,
-0.025053318589925766,
-0.0034222607500851154,
-0.015325408428907394,
-0.024195637553930283,
-0.009648913517594337,
0.04536681994795799,
-0.014174309559166431,
-0.009959258139133453,
-0.01882384531199932,
0.034532953053712845,
0.012097818776965141,
0.03843766078352928,
-0.0027846423909068108,
0.009265214204788208,
-0.015223841182887554,
0.03523264080286026,
-0.023879649117588997,
-0.0021286855917423964,
0.002815677085891366,
0.04965522512793541,
0.04017559066414833,
-0.008362391032278538,
-0.003676179563626647,
0.005896558053791523,
0.005730100441724062,
0.014817571267485619,
0.03304329514503479,
-0.029183730483055115,
-0.003992167301476002,
-0.019342968240380287,
0.04516368359327316,
0.001681506517343223,
-0.0487072616815567,
-0.025775576010346413,
0.007019443437457085,
-0.013880892656743526,
0.001320377574302256,
0.017571179196238518,
0.04534424841403961,
-0.012041392736136913,
-0.02870974875986576,
-0.02712981030344963,
0.007064584642648697,
0.03126022219657898,
-0.03182448446750641,
-0.03527778014540672,
0.019083406776189804,
-0.048346132040023804,
0.022017577663064003,
-0.009631984867155552,
0.037083424627780914,
0.009434493258595467,
0.042274653911590576,
0.0025575263425707817,
0.004138875752687454,
0.01314734946936369,
-0.01017932128161192,
-0.02731037512421608,
0.0269266739487648,
0.0018620709888637066,
0.0315987803041935,
-0.022040149196982384,
-0.029183730483055115,
-0.004254550207406282,
0.0072620767168700695,
-0.0399724580347538,
-0.006393110379576683,
-0.015280267223715782,
0.015584969893097878,
-0.029544860124588013,
-0.06134677305817604,
0.06157248094677925,
0.03026711754500866,
-0.04947466030716896,
-0.00657931761816144,
0.003267088206484914,
-0.00860502477735281,
-0.00593605637550354,
-0.00504169799387455,
-0.004299690946936607,
0.017322903499007225,
-0.0024489054922014475,
-0.017875881865620613,
0.009293426759541035,
-0.017661461606621742,
-0.01639750972390175,
0.02611413411796093,
0.06816308200359344,
-0.012470233254134655,
-0.017300331965088844,
-0.020719772204756737,
0.014998135156929493,
0.0339912585914135,
0.015381834469735622,
-0.0053915418684482574,
-0.01942196488380432,
-0.0032219470012933016,
-0.06261072307825089,
-0.03229846805334091,
-0.016160519793629646,
0.011747974902391434,
-0.0028763352893292904,
-0.0233379565179348,
-0.05444018542766571,
0.004477434325963259,
0.016160519793629646,
-0.017853310331702232,
-0.018327292054891586,
0.026475263759493828,
0.0051263379864394665,
0.024601906538009644,
-0.02396993152797222,
0.041687820106744766,
0.028145484626293182,
-0.033111006021499634,
0.03324643149971962,
-0.0116689782589674,
-0.019117262214422226,
-0.0018112872494384646,
-0.014727288857102394,
-0.03701571375131607,
0.02437620237469673,
0.011736690066754818,
-0.010309102013707161,
-0.029386864975094795,
0.04816557094454765,
0.0005134801613166928,
-0.005504394415766001,
0.02791977860033512,
-0.0018310364102944732,
0.054124195128679276,
0.022299710661172867,
0.001364813419058919,
-0.019139831885695457,
0.003100630361586809,
-0.007989977486431599,
-0.0193881094455719,
0.007549851201474667,
-0.0021879333071410656,
0.05791604891419411,
0.04412543773651123,
-0.020494066178798676,
-0.03150849789381027,
-0.002341695362702012,
0.003018812043592334,
-0.013350484892725945,
-0.0223787073045969,
-0.004375866614282131,
-0.016871491447091103,
-0.012842646799981594,
-0.022119145840406418,
-0.007058941759169102,
0.013226346112787724,
0.029228871688246727,
0.020900335162878036,
0.01336176972836256,
0.023292815312743187,
0.061662763357162476,
-0.010258317925035954,
0.004632607102394104,
-0.01599123887717724,
0.010822582058608532,
0.014208165928721428,
-0.021667735651135445,
0.024285919964313507,
0.0007829162059351802,
-0.024601906538009644,
0.02690410427749157,
0.018101586028933525,
0.004200945142656565,
-0.015370549634099007,
-0.015404405072331429,
-0.009620700031518936,
0.010687158443033695,
-0.03525520861148834,
0.027445796877145767,
-0.02036992833018303,
-0.01936553791165352,
-0.028055202215909958,
0.00668088486418128,
0.0005000788951292634,
-0.03358498960733414,
0.002815677085891366,
0.0044605061411857605,
-0.008114115335047245,
-0.01265079714357853,
0.0040288446471095085,
0.025888429954648018,
-0.01287650316953659,
-0.02591099962592125,
0.02435363084077835,
-0.037670258432626724,
0.009733553044497967,
-0.042048949748277664,
-0.002317714039236307,
-0.013282773084938526,
-0.004999378230422735,
0.006150476634502411,
-0.01722133532166481,
-0.02771664410829544,
0.0062746149487793446,
-0.015088417567312717,
-0.012188101187348366,
-0.016894062981009483,
-0.009953616186976433,
-0.01028088852763176,
-0.03900192305445671,
0.02575300633907318,
-0.016465220600366592,
-0.04150725528597832,
0.0317116342484951,
0.021656449884176254,
-0.018744848668575287,
-0.01029217429459095,
-0.005715993698686361,
0.008779946714639664,
0.002804391784593463,
0.0029454578179866076,
-0.0007208471652120352,
-0.01605895161628723,
-0.019534816965460777,
-0.002120221732184291,
0.03541320562362671,
-0.027265233919024467,
0.0017407542327418923,
0.03105708584189415,
-0.010963648557662964,
-0.005622889846563339,
-0.02392479032278061,
0.014219450764358044,
-0.00440972251817584,
0.007752986624836922,
-0.013023211620748043,
-0.020685914903879166,
0.012684653513133526,
0.028958024457097054,
-0.0050558047369122505,
0.02198372222483158,
0.0057385643012821674,
-0.005975555162876844,
0.00021371495677158237,
0.0076739895157516,
0.021859584376215935,
0.014185595326125622,
-0.005583391524851322,
-0.0044717914424836636,
-0.0028862101025879383,
-0.02198372222483158,
-0.0055410717613995075,
0.05191228166222572,
-0.00840753223747015,
-0.01740190014243126,
0.006573674734681845,
0.02753607928752899,
0.004914738703519106,
0.019230114296078682,
-0.00819311197847128,
0.004474612884223461,
-0.023811938241124153,
-0.006161761935800314,
0.019455820322036743,
0.03992731496691704,
0.013124778866767883,
0.022062718868255615,
0.009028223343193531,
-0.019726667553186417,
-0.025075888261198997,
-0.008785589598119259,
-0.013993745669722557,
-0.02233356609940529,
0.018756132572889328,
-0.01801130548119545,
0.021464599296450615,
-0.012447662651538849,
-0.01979437842965126,
0.04055929183959961,
0.018112871795892715,
0.008723520673811436,
0.003473044605925679,
-0.008447031490504742,
0.03189219906926155,
-0.0036366810090839863,
-0.03861822187900543,
0.012041392736136913,
-0.01699562929570675,
-0.03595489636063576,
-0.011793116107583046,
0.007166151888668537,
-0.013057067058980465,
-0.028551755473017693,
0.004299690946936607,
0.0037495337892323732,
0.015257696621119976,
-0.014862711541354656,
-0.00812540017068386,
0.006816308479756117,
0.023292815312743187,
0.017706602811813354,
-0.014546724036335945,
-0.05425962060689926,
0.0003717088548000902,
0.019839519634842873,
0.0174131840467453,
0.0012181047350168228,
0.001894516171887517,
0.00019290772615931928,
0.06121135130524635,
-0.007865839637815952,
0.033269003033638,
-0.01722133532166481,
0.017706602811813354,
-0.028642037883400917,
0.010969290509819984,
-0.009524774737656116,
-0.025166170671582222,
0.001633544103242457,
-0.03600003942847252,
-0.012932929210364819,
-0.0031203795224428177,
0.008136685937643051,
-0.0053746141493320465,
-0.018688421696424484,
-0.0054197548888623714,
-0.0007786842179484665,
-0.011505341157317162,
0.005168657749891281,
-0.006517248228192329,
-0.0062464019283652306,
-0.0025857393629848957,
0.016769923269748688,
0.018835129216313362,
0.007702202536165714,
-0.0022485917434096336,
-0.044418856501579285,
0.015528542920947075,
-0.02272855117917061,
0.03162135183811188,
-0.014580580405890942,
0.007702202536165714,
0.008176184259355068,
0.01198496576398611,
0.06410038471221924,
0.02435363084077835,
0.010218819603323936,
-0.0032614455558359623,
-0.05778062716126442,
-0.013406910933554173,
0.03182448446750641,
-0.029003165662288666,
0.02751350961625576,
0.014524153433740139,
-0.045818231999874115,
0.0199862290173769,
-0.015788104385137558,
-0.028777459636330605,
-0.03963389992713928,
0.002766303950920701,
0.0201667919754982,
0.013406910933554173,
-0.006353612057864666,
-0.005281510297209024,
-0.04712732508778572,
0.006505962926894426,
0.011522269807755947,
0.02135174721479416,
0.005281510297209024,
-0.0012145781656727195,
0.003326335921883583,
0.037692829966545105,
0.014400015585124493,
0.012560514733195305,
-0.011747974902391434,
-0.006714740768074989,
0.04001759737730026,
-0.039701610803604126,
-0.008497814647853374,
0.006449536886066198,
0.008458316326141357,
-0.016747353598475456,
-0.0312376506626606,
0.01800001971423626,
-0.008565526455640793,
-0.028416331857442856,
-0.0029257084242999554,
0.03746712580323219,
-0.0009275088086724281,
-0.020516635850071907,
0.029432006180286407,
0.0375799760222435,
0.001189891598187387,
-0.02101318910717964,
-0.012436376884579659,
-0.014287162572145462,
-0.008937940932810307,
-0.010512237437069416,
-0.015223841182887554,
-0.018846414983272552,
-0.012955499812960625,
0.023631373420357704,
0.009524774737656116,
0.0029257084242999554,
0.0044605061411857605,
-0.039092205464839935,
0.010918507352471352,
0.002231663791462779,
-0.026791252195835114,
-0.0038595653604716063,
-0.009394994005560875,
0.021329175680875778,
-0.021216323599219322,
-0.0030498465057462454,
0.003202197840437293,
-0.019929802045226097,
-0.0013366001658141613,
-0.036316026002168655,
-0.0034250819589942694,
-0.0028721033595502377,
-0.023247674107551575,
-0.0074990675784647465,
0.00464389193803072,
0.029386864975094795,
0.005177121609449387,
-0.047804441303014755,
-0.029973700642585754,
-0.029747994616627693,
0.002654861891642213,
0.015607540495693684,
-0.03442009910941124,
0.020708486437797546,
0.029161160811781883,
-0.02514360100030899,
0.003915991634130478,
0.00928778387606144,
-0.027852067723870277,
0.022920401766896248,
-0.00959812942892313,
0.006094050593674183,
0.01762760430574417,
-0.02354109100997448,
-0.02276240661740303,
-0.010833867825567722,
0.014151738956570625,
0.0073015750385820866,
0.01324891671538353,
0.015979954972863197,
0.030944233760237694,
0.02514360100030899,
0.02293168567121029,
0.008729162625968456,
0.046585630625486374,
-0.016081521287560463,
-0.01819186843931675,
0.02688153274357319,
-0.02654297463595867,
-0.03232103958725929,
0.008091544732451439,
-0.005828846246004105,
-0.018293436616659164,
0.0005057215457782149,
0.026226988062262535,
0.04550224170088768,
-0.00025127377011813223,
-0.00999875646084547,
-0.005704708397388458,
-0.035684049129486084,
-0.022062718868255615,
0.004088092129677534,
-0.030357399955391884,
0.027829496189951897,
0.0025476517621427774,
0.0134633369743824,
0.00257022213190794,
0.0035097217187285423,
0.00082241470227018,
0.015302837826311588,
0.01484014093875885,
-0.018169298768043518,
-0.020539207383990288,
0.011093429289758205,
-0.016736067831516266,
0.01178183127194643,
0.01436616014689207,
0.015573684126138687,
-0.009626342914998531,
-0.021882155910134315,
-0.009084649384021759,
-0.029815705493092537,
-0.008633238263428211,
-0.011736690066754818,
-0.017153622582554817,
-0.0009063489269465208,
0.01639750972390175,
0.006127906497567892,
0.028529183939099312,
0.02078748308122158,
0.013610046356916428,
-0.0041953022591769695,
-0.04290663078427315,
0.002131507033482194,
-0.04073985666036606,
0.02430848963558674,
-0.0009465527255088091,
0.03065081685781479,
0.026068992912769318,
0.0005318187759257853,
0.014716003090143204,
-0.022796262055635452,
-0.01801130548119545,
-0.0021032937802374363,
-0.018474001437425613,
-0.001065753516741097,
-0.005002199672162533,
-0.00017192416999023408,
-0.0004062700318172574,
0.01841757446527481,
-0.03859565407037735,
0.018237009644508362,
0.029454577714204788,
-0.012334809638559818,
0.029206300154328346,
0.0016603466356173158,
-0.0030131693929433823,
0.016894062981009483,
0.0033968689385801554,
0.011194996535778046,
-0.005868345033377409,
-0.0013288415502756834,
0.009530417621135712,
0.013316628523170948,
-0.005447968374937773,
-0.009440135210752487,
0.012560514733195305,
-0.011635121889412403,
0.0269266739487648,
-0.0284840427339077,
-0.05119002237915993,
0.02652040496468544,
-0.022875260561704636,
0.0260915644466877,
-0.0020116008818149567,
0.021047044545412064,
0.011381203308701515,
0.018485287204384804,
-0.0027479652781039476,
0.01524641178548336,
-0.014998135156929493,
-0.009750480763614178,
0.005690601654350758,
0.00588527275249362,
-0.02512102946639061,
-0.0156188253313303,
-0.008294680155813694,
0.008328535594046116,
0.006060194689780474,
0.03340442478656769,
0.005930413957685232,
0.019139831885695457,
-0.030741099268198013,
0.008842015638947487,
0.010534808039665222,
0.0003865207836497575,
-0.014558009803295135,
0.024443913251161575,
0.0045931083150208,
0.007617563009262085,
0.014546724036335945,
-0.024872753769159317,
-0.019929802045226097,
-0.0059868404641747475,
-0.03396868705749512,
-0.007865839637815952,
-0.015889672562479973,
-0.00499091437086463,
0.09615057706832886,
-0.009428850375115871,
0.026226988062262535,
-0.00039533741073682904,
-0.007075869478285313,
0.008723520673811436,
-0.008537312969565392,
0.02057306282222271,
0.01116114016622305,
-0.029612571001052856,
0.035142358392477036,
0.005078375339508057,
0.03105708584189415,
0.013689043000340462,
0.008870229125022888,
-0.015867101028561592,
-0.007640133611857891,
0.011849542148411274,
-0.01019624900072813,
-0.030425110831856728,
0.004327904433012009,
0.007916622795164585,
-0.018654566258192062,
0.05340193957090378,
0.01600252464413643,
0.01436616014689207,
0.015212555415928364,
-0.00775862904265523,
-0.016374940052628517,
-0.0003635975590441376,
0.004722889047116041,
0.0032416963949799538,
0.018056446686387062,
-0.04545710235834122,
0.031192509457468987,
0.00692916102707386,
-0.0134633369743824,
-0.006551104132086039,
0.006686527747660875,
-0.00321630435064435,
-0.01425330713391304,
-0.011110357008874416,
0.019083406776189804,
0.01996365748345852,
0.001014969777315855,
0.005504394415766001,
0.01623951643705368,
-0.0060545518063008785,
0.0019438891904428601,
-0.01844014599919319,
0.003828530665487051,
-0.016476506367325783,
0.028935454785823822,
0.015189984813332558,
-0.009445778094232082,
-0.00434483215212822,
0.014772430062294006,
-0.03006398305296898,
-0.024466484785079956,
-0.016183089464902878,
-0.008052046410739422,
0.039069633930921555,
0.027220092713832855,
-0.00232194596901536,
0.04789472371339798
] | 2024-07-04 | 79 | 38959896 | [
"Plasma cells",
"plasma cells",
"engineered plasma cells",
"human plasma cells",
"anti-CD19 bispecifics",
"cell delivery",
"acute myeloid leukemia cell lines",
"bispecific antibodies",
"acute leukemias",
"Plasma",
"B acute lymphoblastic leukemia",
"anti-CD19-bispecific antibodies",
"anti-CD19-bispecific secretion",
"direct T cell killing",
"acute lymphoblastic leukemia patient-derived xenografts",
"mediate T cell activation",
"Bispecific antibodies",
"autologous T cells",
"vivo control",
"leukemic control",
"further development",
"anti-CD3 (blinatumomab",
"immunodeficient mice",
"patients",
"tumor eradication",
"CD19-targeted chimeric antigen receptor-expressing T cells",
"clinical translation",
"treatment",
"CD19",
"secretion"
] | [
"T cell engager",
"bispecific",
"engineered plasma cells",
"engineering",
"engraftment",
"gene editing",
"in vivo",
"leukemia",
"plasma cells"
] | 0 | 10.1016/j.ymthe.2024.06.004
10.1126/sciimmunol.aax0644
10.3390/ijms22189991
10.3390/biomedicines6010022
10.1101/2022.08.25.505190
10.3390/cancers14020458
10.1136/jitc-2020-001202
10.1093/ajcp/aqw151.007 | [
"Hill",
"Narvekar",
"Asher",
"Edelstein",
"Camp",
"Grimm",
"Thomas",
"Leiken",
"Molloy",
"Cook",
"Arlauckas",
"Morgan",
"Tasian",
"Rawlings",
"James"
] | [
"University of Washington, Medical Scientist Training Program, Seattle, WA, USA; Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.",
"Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.",
"Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.",
"BE Biopharma, Cambridge, MA, USA.",
"Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.",
"Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.",
"Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.",
"BE Biopharma, Cambridge, MA, USA.",
"BE Biopharma, Cambridge, MA, USA.",
"Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.",
"BE Biopharma, Cambridge, MA, USA.",
"BE Biopharma, Cambridge, MA, USA.",
"Children's Hospital of Philadelphia, Division of Oncology and Center for Childhood Cancer Research, Philadelphia, PA, USA; Department of Pediatrics and Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.",
"Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA; University of Washington, Departments of Pediatrics and Immunology, Seattle, WA, USA.",
"Seattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA; University of Washington, Departments of Pediatrics and Pharmacology, Seattle, WA, USA. Electronic address: [email protected]."
] | [
"38959896",
"28959944",
"32433532",
"33433946",
"28249141",
"26374073",
"27209293",
"35654820",
"34376374",
"26177629",
"36322929",
"37285013",
"36548927",
"29273498",
"36245034",
"33184267",
"34748076",
"27685947",
"31101673",
"33203876",
"30648968",
"30975893",
"33203857",
"34576154",
"9217150",
"17989383",
"28892076",
"16977339",
"2869953",
"34721441",
"33567286",
"29466292",
"9371608",
"37322036",
"31243002",
"35053619",
"18703743",
"17083975",
"12209608",
"12682277",
"34937317",
"22955920",
"32103893",
"27111235",
"33122397",
"31332324",
"27166358",
"25317870",
"29038338",
"26187412",
"36122038",
"35385358",
"15728125",
"22047558",
"29661681",
"29483708",
"26056165",
"28539325",
"25573986",
"28490574",
"29176567",
"20038800",
"32210425",
"35404084",
"22438945",
"20442809",
"35366963",
"34914545",
"31903177",
"32675220",
"14707116",
"32110574",
"17700388",
"32271314",
"31211405",
"11284774",
"16995864",
"21923591",
"27240277"
] | [] | 6.316014 | 6.625951 |
38959487 | 775 | CD7 CAR T-Cell Therapy and Allogeneic HSCT. Reply. | null | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-03 | 1 | 38959487 | [] | [] | 0 | 10.1056/NEJMc2406366 | [
"Hu",
"Wang",
"Huang"
] | [
"First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China [email protected].",
"First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China [email protected].",
"First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China [email protected]."
] | [
"38959487"
] | [] | 32.998459 | 7.49098 |
38959486 | 776 | CD7 CAR T-Cell Therapy and Allogeneic HSCT. | null | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-03 | 1 | 38959486 | [] | [] | 0 | 10.1056/NEJMc2406366 | [
"Guo",
"Yu",
"Cai"
] | [
"Fifth Medical Center of Chinese PLA General Hospital, Beijing, China [email protected].",
"Fifth Medical Center of Chinese PLA General Hospital, Beijing, China [email protected].",
"Fifth Medical Center of Chinese PLA General Hospital, Beijing, China [email protected]."
] | [
"38959486"
] | [] | 32.956154 | 7.553012 |
38959485 | 777 | CD7 CAR T-Cell Therapy and Allogeneic HSCT. | null | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-03 | 1 | 38959485 | [] | [] | 0 | 10.1056/NEJMc2406366 | [
"Fuji"
] | [
"Osaka International Cancer Institute, Osaka, Japan [email protected]."
] | [
"38959485"
] | [] | 32.99168 | 7.493719 |
38959337 | 778 | Augmenting CAR T-cell Functions with LIGHT. | Chimeric antigen receptor (CAR) T-cell therapy has resulted in remarkable clinical success in the treatment of B-cell malignancies. However, its clinical efficacy in solid tumors is limited, primarily by target antigen heterogeneity. To overcome antigen heterogeneity, we developed CAR T cells that overexpress LIGHT, a ligand of both lymphotoxin-β receptor on cancer cells and herpes virus entry mediator on immune cells. LIGHT-expressing CAR T cells displayed both antigen-directed cytotoxicity mediated by the CAR and antigen-independent killing mediated through the interaction of LIGHT with lymphotoxin-β receptor on cancer cells. Moreover, CAR T cells expressing LIGHT had immunostimulatory properties that improved the cells' proliferation and cytolytic profile. These data indicate that LIGHT-expressing CAR T cells may provide a way to eliminate antigen-negative tumor cells to prevent antigen-negative disease relapse. | [
0.025284893810749054,
-0.014379756525158882,
0.01639879122376442,
0.056720804423093796,
-0.0037387367337942123,
-0.02648223005235195,
0.007935278117656708,
0.009807581081986427,
0.002249404788017273,
-0.011627060361206532,
-0.032445427030324936,
0.0034892919939011335,
-0.04948984086513519,
-0.019380390644073486,
0.025848345831036568,
-0.01716179959475994,
0.0395355261862278,
0.00131692155264318,
-0.0009809047915041447,
0.03176458925008774,
0.024369284510612488,
-0.006356439087539911,
0.007500950712710619,
0.0025179246440529823,
-0.035262685269117355,
-0.015295365825295448,
0.029487304389476776,
0.01709136739373207,
0.0307785477489233,
-0.03169415891170502,
0.008005709387362003,
-0.008733500726521015,
0.020847711712121964,
-0.03329060226678848,
-0.011004915460944176,
0.043127529323101044,
0.04441877454519272,
0.003794495016336441,
-0.016938766464591026,
-0.022232864052057266,
-0.004689561203122139,
0.029487304389476776,
0.03291497007012367,
0.08343780040740967,
-0.025190984830260277,
0.00423762621358037,
-0.010376902297139168,
-0.009719541296362877,
0.004302188288420439,
-0.02348889224231243,
-0.02441623993217945,
-0.008211134001612663,
0.007348348852247,
0.06798983365297318,
-0.07522080093622208,
0.02502664551138878,
-0.03840862214565277,
0.01562404539436102,
0.008310912176966667,
0.03657740354537964,
0.055265218019485474,
-0.011427504010498524,
0.021023791283369064,
-0.01729092374444008,
-0.04796382412314415,
0.006849459372460842,
-0.051696691662073135,
-0.011456850916147232,
0.019955581054091454,
0.03725824132561684,
0.00819939561188221,
-0.03418273478746414,
-0.011010784655809402,
-0.005050522740930319,
0.04845684394240379,
0.019861672073602676,
0.02819606103003025,
0.014755390584468842,
0.027867380529642105,
0.0033924486488103867,
0.03343146666884422,
0.021434640511870384,
-0.004460659343749285,
-0.05906851962208748,
-0.0022846204228699207,
-0.02306630276143551,
-0.0022934244479984045,
-0.040075499564409256,
-0.031130705028772354,
-0.0024665684904903173,
0.026458751410245895,
0.028078675270080566,
-0.046649105846881866,
-0.000053052863222546875,
-0.01911040209233761,
0.005731360055506229,
-0.05099237710237503,
-0.0598197877407074,
0.04601522162556648,
0.02399365045130253,
0.03606090694665909,
0.027186544612050056,
-0.011574236676096916,
-0.03617829456925392,
0.02080075815320015,
0.005916242487728596,
-0.05831724777817726,
0.00047431187704205513,
0.009449554607272148,
-0.01668051816523075,
0.04981851950287819,
-0.001848825835622847,
0.012971127405762672,
0.06845937669277191,
-0.0023022284731268883,
-0.047564711421728134,
0.0022860877215862274,
0.020648157224059105,
0.020366430282592773,
0.008293304592370987,
-0.026223979890346527,
0.04491179436445236,
0.04958374798297882,
-0.0436675064265728,
-0.0008891971665434539,
-0.035779181867837906,
0.09804059565067291,
-0.038831211626529694,
-0.024486670270562172,
-0.05254187062382698,
0.037939079105854034,
0.007900062017142773,
0.013558056205511093,
0.016070110723376274,
-0.05883374810218811,
-0.0032750628888607025,
0.004266972653567791,
0.005704948212951422,
-0.022068524733185768,
0.006755550857633352,
0.015447966754436493,
-0.006949237547814846,
0.01112230122089386,
0.029393395408988,
-0.0128067871555686,
-0.042164966464042664,
0.003938292618840933,
0.009878012351691723,
0.0009046040941029787,
0.031412430107593536,
-0.026177026331424713,
0.010359293781220913,
0.06456217169761658,
0.015823600813746452,
-0.03359580785036087,
-0.05230709910392761,
-0.006861198227852583,
0.053246185183525085,
-0.04256407916545868,
-0.03455837070941925,
0.0017739924369379878,
-0.007195747457444668,
-0.016316622495651245,
0.013569794595241547,
0.008774586021900177,
-0.000374900788301602,
-0.01891084760427475,
0.04517004266381264,
-0.0749390721321106,
-0.02227981947362423,
-0.06244922801852226,
-0.039112936705350876,
-0.04390227794647217,
-0.0340418741106987,
-0.06733247637748718,
-0.0029214383102953434,
0.031623724848032,
0.020718587562441826,
-0.01639879122376442,
-0.03279758244752884,
0.003037356771528721,
0.03488704934716225,
0.06174491345882416,
-0.008498729206621647,
-0.015025378204882145,
0.011826615780591965,
-0.04455963894724846,
0.02537880279123783,
-0.03124809078872204,
-0.02269066870212555,
-0.015459705144166946,
0.029322965070605278,
0.048057734966278076,
0.020718587562441826,
0.019849933683872223,
-0.0031870235688984394,
0.03418273478746414,
0.049255069345235825,
-0.03641306608915329,
-0.03056725300848484,
0.03070811741054058,
-0.013217637315392494,
-0.03655392676591873,
0.0011540488339960575,
-0.026177026331424713,
-0.02812563069164753,
-0.02967512235045433,
0.024157991632819176,
-0.017302662134170532,
0.028689080849289894,
0.041624993085861206,
-0.010570588521659374,
0.0042493646033108234,
0.00892131868749857,
-0.012712878175079823,
-0.00819939561188221,
0.025730960071086884,
0.030473345890641212,
0.008123095147311687,
0.03606090694665909,
-0.027656087651848793,
-0.009737149812281132,
-0.008715893141925335,
-0.010582326911389828,
-0.019133880734443665,
0.01673921011388302,
-0.001137174665927887,
-0.04077981412410736,
0.02744479291141033,
-0.03373666852712631,
-0.023782355710864067,
0.008545683696866035,
-0.013487624935805798,
-0.015412751585245132,
-0.03352537378668785,
-0.011468589305877686,
0.02204504795372486,
-0.007853107526898384,
0.05479567497968674,
-0.030895933508872986,
-0.007324872072786093,
0.02634136565029621,
0.01825348660349846,
-0.03892511874437332,
-0.03373666852712631,
-0.008228742517530918,
-0.010277124121785164,
-0.05366877466440201,
0.0048891170881688595,
-0.03824428468942642,
-0.0001968045689864084,
-0.02413451299071312,
-0.026810908690094948,
-0.0024885782040655613,
0.01535405870527029,
0.0419536717236042,
0.02648223005235195,
-0.0488324798643589,
0.004683692008256912,
-0.04845684394240379,
0.014978423714637756,
0.016222713515162468,
-0.013616749085485935,
-0.05869288370013237,
-0.060946691781282425,
0.0061686220578849316,
-0.016563132405281067,
0.02789085917174816,
0.01619923673570156,
0.011315988376736641,
0.04655519500374794,
0.007876585237681866,
0.05460786074399948,
-0.03145938739180565,
-0.052588824182748795,
-0.01577664725482464,
-0.006914021912962198,
0.03824428468942642,
0.03176458925008774,
0.016281405463814735,
-0.03634263202548027,
0.02094162069261074,
-0.0069316294975578785,
-0.022514590993523598,
-0.036154817789793015,
-0.029252532869577408,
-0.016222713515162468,
-0.02871255949139595,
-0.00564625533297658,
-0.038150373846292496,
0.02324238233268261,
-0.01712658256292343,
-0.02031947672367096,
-0.030285527929663658,
-0.01849999651312828,
0.02152854949235916,
-0.022514590993523598,
-0.0035010306164622307,
-0.020237306132912636,
0.003882534336298704,
-0.021927662193775177,
-0.007706375792622566,
-0.008774586021900177,
-0.06423348933458328,
0.03225760906934738,
0.019309958443045616,
-0.0012640979839488864,
-0.029510781168937683,
0.061463188380002975,
0.021364210173487663,
0.05291750282049179,
-0.008205264806747437,
0.004818685818463564,
0.0343940295279026,
-0.0034100564662367105,
-0.003732867306098342,
0.015940986573696136,
-0.027585655450820923,
0.007524427492171526,
-0.0649847611784935,
-0.04416052624583244,
-0.00009390861669089645,
-0.017666557803750038,
-0.006884675472974777,
0.01673921011388302,
-0.026834387332201004,
0.013968906365334988,
-0.023406721651554108,
-0.003970573656260967,
-0.038291238248348236,
0.04218844324350357,
-0.02523794025182724,
0.0687880590558052,
-0.014098030515015125,
0.04448920488357544,
-0.04108501970767975,
-0.03913641348481178,
-0.03803298994898796,
-0.0026543857529759407,
-0.0028245949652045965,
0.027163065969944,
0.048879433423280716,
-0.04406661540269852,
0.05634516850113869,
0.04930202290415764,
0.013018081896007061,
0.026670046150684357,
0.026083117350935936,
-0.011057739146053791,
0.01495494693517685,
0.010599934495985508,
-0.0027101438026875257,
0.012043779715895653,
-0.011034262366592884,
-0.023406721651554108,
0.04817511886358261,
-0.013170682825148106,
-0.03026205115020275,
0.016457485035061836,
0.01729092374444008,
0.005628647748380899,
0.0071722702123224735,
-0.043338824063539505,
0.029722075909376144,
0.033407989889383316,
0.032680198550224304,
-0.009208913892507553,
0.03270367532968521,
-0.010024745017290115,
-0.016551394015550613,
-0.008815671317279339,
-0.03380710259079933,
0.03681217506527901,
0.0235475841909647,
0.002531130565330386,
0.03603743016719818,
0.007013799622654915,
0.019709071144461632,
0.004187737125903368,
-0.037281718105077744,
0.03035596013069153,
-0.020542509853839874,
-0.004739450290799141,
-0.02620050311088562,
-0.01798349991440773,
0.019169095903635025,
0.023148473352193832,
-0.00038517205393873155,
-0.04556915536522865,
0.009960182011127472,
0.025777915492653847,
-0.012255074456334114,
0.009490638971328735,
-0.007583120372146368,
-0.010987307876348495,
0.07376521825790405,
-0.007882454432547092,
0.0780380591750145,
0.05587562546133995,
0.018758244812488556,
-0.019826456904411316,
-0.03152981773018837,
-0.009995398111641407,
-0.0276795644313097,
0.0015216129831969738,
-0.02083597332239151,
0.032445427030324936,
0.0022332642693072557,
0.05366877466440201,
-0.014931469224393368,
0.0032574550714343786,
0.03723476454615593,
0.029698599129915237,
0.01310025155544281,
-0.02744479291141033,
-0.02634136565029621,
0.0026954705826938152,
0.021129438653588295,
0.006450348068028688,
0.006209706887602806,
0.023735402151942253,
-0.04446572810411453,
0.04373793676495552,
-0.019650377333164215,
0.008023316971957684,
-0.00921478308737278,
0.03211674466729164,
0.018558690324425697,
-0.004281645640730858,
-0.03648349642753601,
-0.016727471724152565,
0.04009898006916046,
0.03448794037103653,
0.01757264882326126,
-0.005974935367703438,
0.019673854112625122,
-0.04019288718700409,
-0.0038619916886091232,
-0.05141496658325195,
0.013534579426050186,
-0.01925126649439335,
0.030144665390253067,
0.002476839581504464,
-0.059397198259830475,
0.019920364022254944,
-0.0194273442029953,
-0.00012215456808917224,
0.026881340891122818,
-0.001950071076862514,
0.01365196518599987,
-0.010594065301120281,
-0.019556468352675438,
-0.039253801107406616,
-0.002620637184008956,
-0.029252532869577408,
0.00041965412674471736,
0.03566179797053337,
-0.06512562185525894,
0.004704234655946493,
0.02730393037199974,
0.013229375705122948,
-0.05620430409908295,
0.0240640826523304,
-0.05883374810218811,
0.0026954705826938152,
0.05108628422021866,
0.05676775798201561,
-0.02833692356944084,
0.030309004709124565,
-0.01873476803302765,
0.023336291313171387,
0.009948443621397018,
0.016621824353933334,
0.017666557803750038,
-0.007295525632798672,
0.07296699285507202,
0.024228421971201897,
0.02826649323105812,
0.01808914728462696,
-0.008839148096740246,
0.008616114966571331,
-0.003726998111233115,
-0.04512308910489082,
-0.026177026331424713,
0.05141496658325195,
0.04063895344734192,
-0.016375314444303513,
0.0022347315680235624,
-0.022115478292107582,
0.030379436910152435,
-0.015330580994486809,
-0.024298854172229767,
0.004613260738551617,
-0.010306470096111298,
-0.024392763152718544,
-0.003231043228879571,
-0.01584707945585251,
-0.034088827669620514,
-0.013558056205511093,
-0.01678616553544998,
-0.002501784125342965,
0.020519033074378967,
-0.016105327755212784,
0.005807660985738039,
0.049395930022001266,
0.03291497007012367,
0.01206725649535656,
0.037187810987234116,
-0.0011973348446190357,
0.008809802122414112,
-0.04218844324350357,
-0.016316622495651245,
0.025942254811525345,
0.012853741645812988,
-0.04380836710333824,
-0.013417193666100502,
-0.08353171497583389,
0.005792987532913685,
-0.006702727172523737,
-0.00479520857334137,
-0.014520619064569473,
0.005963196977972984,
-0.008762847632169724,
0.015013639815151691,
0.02399365045130253,
-0.02306630276143551,
-0.01716179959475994,
-0.006473825313150883,
-0.030543776229023933,
-0.04063895344734192,
0.016351837664842606,
-0.024392763152718544,
0.00771811418235302,
0.0008437102078460157,
0.00047944748075678945,
-0.012290289625525475,
-0.03939466178417206,
0.037187810987234116,
-0.0013704788871109486,
-0.03493400290608406,
0.013381977565586567,
-0.02114117704331875,
0.03650697320699692,
0.008563291281461716,
0.01801871508359909,
0.03359580785036087,
-0.002645581727847457,
-0.03242195025086403,
0.021059006452560425,
-0.015166240744292736,
0.04556915536522865,
-0.04115545004606247,
0.0023741270415484905,
-0.0037416713312268257,
-0.005901569500565529,
-0.019075186923146248,
-0.020483816042542458,
-0.0256135743111372,
-0.011814877390861511,
0.0009332168265245855,
-0.027116112411022186,
-0.01034755539149046,
0.013123729266226292,
-0.007988101802766323,
-0.009995398111641407,
0.008610245771706104,
0.021152915433049202,
0.01026538573205471,
-0.02317195013165474,
0.01677442528307438,
-0.00424643000587821,
-0.00864546187222004,
0.020366430282592773,
0.0037592791486531496,
0.04364402964711189,
0.0008642527391202748,
-0.0070901005528867245,
-0.0006115064607001841,
0.0017505153082311153,
0.01499016210436821,
-0.030919410288333893,
-0.005282359663397074,
-0.016480961814522743,
0.05061674118041992,
-0.0071135773323476315,
0.015072332695126534,
-0.05146192014217377,
-0.024486670270562172,
-0.025965731590986252,
0.006045367103070021,
0.005056391935795546,
0.01767829619348049,
0.01402759924530983,
0.0028700819239020348,
-0.038666870445013046,
0.004011658485978842,
0.04596826806664467,
0.009373253211379051,
-0.022232864052057266,
-0.012924172915518284,
0.016903551295399666,
0.01053537242114544,
-0.003195827594026923,
-0.04183628782629967,
-0.023958435282111168,
0.033055830746889114,
-0.006714466027915478,
-0.03709390386939049,
-0.005487784743309021,
-0.0006426870822906494,
0.03498096019029617,
0.028923852369189262,
-0.012384198606014252,
-0.004375554621219635,
-0.00423762621358037,
0.0019427344668656588,
-0.023911481723189354,
-0.0249327365309,
-0.000407548708608374,
-0.0261300727725029,
-0.019720809534192085,
-0.01032994780689478,
-0.029628166928887367,
0.031647201627492905,
-0.0032926707062870264,
-0.028970807790756226,
-0.05352791026234627,
-0.021540287882089615,
0.013816304504871368,
0.01939212903380394,
-0.0002250505203846842,
-0.044888317584991455,
0.012842003256082535,
0.04073286056518555,
0.0020630548242479563,
-0.04639085382223129,
0.004293384496122599,
0.006244922988116741,
0.005464307498186827,
0.0018767049768939614,
0.01236072089523077,
0.02159898169338703,
0.01368718035519123,
-0.04967765510082245,
0.01695050485432148,
-0.016633562743663788,
-0.043479688465595245,
0.00716053182259202,
0.01746700145304203,
-0.0009148753015324473,
0.005781249143183231,
-0.014544096775352955,
0.026247458532452583,
-0.00753029715269804,
0.016034895554184914,
-0.0276795644313097,
0.009561071172356606,
0.022855008020997047,
0.0598197877407074,
0.06578298658132553,
-0.017373094335198402,
0.02290196344256401,
-0.014544096775352955,
-0.0069022830575704575,
-0.005343987140804529,
-0.008933057077229023,
0.003929488360881805,
-0.00818178802728653,
0.013299807906150818,
-0.007900062017142773,
0.0942372977733612,
0.050428926944732666,
0.0014944676076993346,
-0.022185910493135452,
-0.018593905493617058,
0.021775059401988983,
-0.00782376155257225,
-0.004580979701131582,
-0.03420621156692505,
-0.009032835252583027,
0.029487304389476776,
0.006115798372775316,
-0.028407355770468712,
-0.07902409881353378,
-0.0006771691259928048,
0.017173537984490395,
0.00452228682115674,
0.004842163063585758,
0.0030989842489361763,
0.0032926707062870264,
-0.010106914676725864,
-0.0032691936939954758,
-0.02523794025182724,
-0.006855329032987356,
0.02737436071038246,
-0.001684485818259418,
0.008240480907261372,
-0.018922585994005203,
-0.0235593244433403,
0.0107466671615839,
0.02575443685054779,
0.020483816042542458,
0.03502791374921799,
-0.028477787971496582,
0.025402279570698738,
-0.016387052834033966,
-0.026458751410245895,
0.00040791553328745067,
0.037774741649627686,
0.025801392272114754,
0.0069609759375452995,
0.012607231736183167,
-0.016081850975751877,
-0.008275697007775307,
-0.0030608337838202715,
0.01876998506486416,
-0.02038990706205368,
0.05789466202259064,
-0.007982232607901096,
-0.001866433653049171,
0.0055494122207164764,
0.02276110090315342,
-0.020448600873351097,
-0.010464941151440144,
0.04930202290415764,
0.013640225864946842,
-0.02983946166932583,
0.049395930022001266,
-0.026810908690094948,
0.0107466671615839,
-0.008950664661824703,
-0.03753997012972832,
-0.032445427030324936,
0.017549172043800354,
-0.030238574370741844,
-0.0029419807251542807,
-0.016492700204253197,
-0.01461452804505825,
0.011450981721282005,
-0.018593905493617058,
0.026998726651072502,
0.00041965412674471736,
-0.01784263737499714,
0.007448127027601004,
0.019685592502355576,
0.03322017192840576,
0.021434640511870384,
-0.0020278391893953085,
0.0014937338419258595,
-0.033642761409282684,
0.024838827550411224,
0.007917669601738453,
-0.012219858355820179,
0.0010506026446819305,
0.00273802294395864,
-0.01354631781578064,
0.014638004824519157,
0.012290289625525475,
-0.019591685384511948,
-0.037493012845516205,
-0.01750221848487854,
0.013276330195367336,
0.00924999825656414,
0.013757611624896526,
0.0028847551438957453,
0.008375474251806736,
-0.0023022284731268883,
-0.0128067871555686,
-0.028970807790756226,
-0.006514910142868757,
-0.013851520605385303,
-0.0038179720286279917,
0.008105487562716007,
-0.014919730834662914,
-0.020190352573990822,
0.012947650626301765,
-0.02341846004128456,
-0.013194160535931587,
0.00816418044269085,
-0.003947096411138773,
0.0034951611887663603,
-0.016117066144943237,
-0.018417827785015106,
0.001911920728161931,
-0.0016140543157234788,
-0.015377535484731197,
-0.00422882242128253,
0.01983819529414177,
-0.02014339715242386,
-0.009208913892507553,
-0.006855329032987356,
0.02434580773115158,
-0.015177980065345764,
0.026388321071863174,
-0.003049095394089818,
0.04596826806664467,
0.03819732740521431,
-0.07259135693311691,
-0.020988576114177704,
0.00706662330776453,
-0.020918143913149834,
-0.02049555443227291,
0.012595492415130138,
-0.004478266928344965,
-0.014720175415277481,
0.0043872930109500885,
-0.03655392676591873,
0.009255867451429367,
-0.03599047660827637,
0.010371032170951366,
0.012407675385475159,
0.0037710177712142467,
-0.03681217506527901,
-0.01554187573492527,
-0.05446699634194374,
-0.02358280122280121,
0.03737562894821167,
0.010523634031414986,
0.00764181325212121,
-0.005452569108456373,
0.040967632085084915,
0.004305122885853052,
0.01557709090411663,
-0.017971761524677277,
0.005933850537985563,
-0.042446695268154144,
-0.020002534613013268,
0.04143717512488365,
0.03354885056614876,
-0.023477153852581978,
0.04167194664478302,
-0.005000633653253317,
-0.03958247974514961,
0.033713191747665405,
-0.027421316131949425,
-0.020260782912373543,
0.016304882243275642,
0.007958754897117615,
-0.009273475967347622,
0.011468589305877686,
0.0008671873365528882,
-0.014156723394989967,
-0.02554314211010933,
-0.0333610363304615,
0.0028656800277531147,
0.0058692884631454945,
-0.01646922342479229,
0.017854375764727592,
-0.029769031330943108,
-0.0018781722756102681,
0.020718587562441826,
-0.008445905521512032,
-0.005881026852875948,
-0.02313673496246338,
0.023183688521385193,
0.005153235048055649,
0.003735802136361599,
-0.04239973798394203,
0.06108755245804787,
0.01784263737499714,
-0.028618650510907173,
-0.004266972653567791,
0.000048971873184200376,
-0.03251585736870766,
0.052588824182748795,
-0.02739783748984337,
0.02744479291141033,
0.013053297065198421,
0.015365797095000744,
-0.03671826794743538,
0.050428926944732666,
-0.0050475881434977055,
0.014098030515015125,
0.015741432085633278,
-0.015870556235313416,
0.024674488231539726,
0.015131025575101376,
-0.020929882302880287,
-0.00971367210149765,
0.03486357256770134,
0.010417986661195755,
-0.034511417150497437,
-0.005062261130660772,
-0.012043779715895653,
-0.0005883961566723883,
-0.0007879519835114479,
-0.004196541383862495,
-0.006561864633113146,
-0.0010168541921302676,
-0.0015274822944775224,
0.006491432897746563,
-0.005757771898061037,
-0.02172810584306717,
-0.03190544992685318,
-0.017924806103110313,
-0.02685786411166191,
-0.0059778704307973385,
0.05634516850113869,
-0.02885342203080654,
-0.027867380529642105,
-0.022678930312395096,
-0.03195240721106529,
-0.02231503464281559,
0.03737562894821167,
0.022162433713674545,
0.003327886573970318,
-0.017420047894120216,
0.009977790527045727,
0.006462086457759142,
0.04108501970767975,
0.009743019007146358,
-0.012677663005888462,
-0.01653965376317501,
0.011374681256711483,
-0.031036796048283577,
0.019263004884123802,
-0.02358280122280121,
0.06892891973257065,
0.005320509895682335,
-0.0013521373039111495,
-0.025402279570698738,
0.013475886546075344,
0.016316622495651245,
0.034018393605947495,
-0.0026851994916796684,
0.02389974147081375,
0.018746506422758102,
-0.004548698663711548,
0.0001993723853956908,
0.017666557803750038,
-0.002661722246557474,
-0.00155829603318125,
0.04101458564400673,
-0.019591685384511948,
0.03951204940676689,
-0.001798936864361167,
0.03366623818874359,
0.007377695292234421,
0.005206058733165264,
-0.006421001628041267,
-0.02789085917174816,
0.0196034237742424,
-0.016246190294623375,
-0.04542829096317291,
0.018206533044576645,
-0.003533311653882265,
0.006145144812762737,
-0.05841115862131119,
0.0481281653046608,
0.040451135486364365,
0.05676775798201561,
0.005153235048055649,
0.046226516366004944,
0.02620050311088562,
-0.01653965376317501,
-0.006391655188053846,
-0.0066909887827932835,
-0.009831057861447334,
0.04610912874341011,
-0.008692416362464428,
-0.008299173787236214,
0.014755390584468842,
-0.000588762981351465,
0.015131025575101376,
0.011591844260692596,
0.039183370769023895,
0.01619923673570156,
0.009555201046168804,
-0.03847905620932579,
0.03035596013069153,
0.014778868295252323,
-0.038291238248348236,
0.006708596833050251,
0.03669479116797447,
-0.0038355798460543156,
0.029862938448786736,
0.019439082592725754,
-0.04291623830795288,
-0.002805519849061966,
0.012877218425273895,
0.03056725300848484,
0.01480234507471323,
-0.017373094335198402,
0.01373413484543562,
-0.022197648882865906,
0.006151014007627964,
-0.007894192822277546,
-0.044747453182935715,
-0.03425316512584686,
0.026763955131173134,
0.03239847347140312,
0.04448920488357544,
-0.02208026312291622,
-0.007154662627726793,
0.009895619936287403,
-0.030966365709900856,
-0.028477787971496582,
-0.05291750282049179,
0.01272461749613285,
0.03458184748888016,
-0.036225248128175735,
-0.019169095903635025,
0.009056312032043934,
0.0066909887827932835,
-0.024674488231539726,
0.012102472595870495,
0.014450187794864178,
0.00034537093597464263,
0.010189084336161613,
-0.010294731706380844,
0.004396096803247929,
0.016762686893343925,
-0.00660294946283102,
0.013828043825924397,
0.012536799535155296,
-0.01764308102428913,
-0.023711925372481346,
-0.0058458112180233,
-0.03744605928659439,
0.004886182490736246,
0.007383564952760935,
-0.009795842692255974,
-0.005162039306014776,
0.05033501610159874,
0.00024687693803571165,
-0.014414972625672817,
0.006344700697809458,
-0.009179566986858845,
0.008158311247825623,
0.03627220168709755,
0.007025538012385368,
-0.01980297826230526,
0.00921478308737278,
-0.023664969950914383,
-0.025519665330648422,
0.008076140657067299,
-0.007007930427789688,
0.056720804423093796,
0.002610366092994809,
-0.0034599455539137125,
-0.045545678585767746,
-0.015037116594612598,
-0.007524427492171526,
0.0412493571639061,
-0.057331208139657974,
-0.005725490860641003,
0.007436388172209263,
0.0014269707025960088,
0.01535405870527029,
0.02231503464281559,
0.02249111235141754,
0.05000633746385574,
-0.006209706887602806,
0.04580392688512802,
0.01736135594546795,
0.03493400290608406,
0.0035655926913022995,
0.020096443593502045,
0.028689080849289894,
0.011057739146053791,
-0.021822014823555946,
0.02159898169338703,
-0.009038704447448254,
0.002110009081661701,
-0.012689401395618916,
-0.0120320413261652,
0.024157991632819176,
0.02062467858195305,
0.01935691386461258,
0.012419413775205612,
-0.018100885674357414,
0.019673854112625122,
-0.007313133217394352,
0.029346441850066185,
-0.007565512787550688,
0.004557502456009388,
-0.004360881168395281,
-0.025965731590986252,
-0.009842796251177788,
-0.04653171822428703,
0.03486357256770134,
0.01065862737596035,
0.019309958443045616,
-0.014896254055202007,
-0.009461292997002602,
0.0171970147639513,
-0.023394983261823654,
-0.027867380529642105,
0.008891971781849861,
-0.0008642527391202748,
-0.009795842692255974,
0.006608818657696247,
-0.023535845801234245,
-0.0025956928730010986,
-0.018640859052538872,
0.017243970185518265,
-0.009091528132557869,
0.032609764486551285,
0.03871382772922516,
-0.011926393955945969,
-0.009795842692255974,
0.03291497007012367,
0.0032369126565754414,
-0.04315100982785225,
-0.030027279630303383,
0.06587689369916916,
-0.016551394015550613,
-0.0440196618437767,
0.024815350770950317,
0.015741432085633278,
-0.013276330195367336,
-0.0010990242008119822,
0.017666557803750038,
-0.023289335891604424,
0.009496508166193962,
-0.00723683275282383,
0.00498596066609025,
-0.019861672073602676,
0.010218431241810322,
-0.0069609759375452995,
-0.015670999884605408,
-0.020436862483620644,
0.02111770026385784,
0.03721128776669502,
-0.00771811418235302,
-0.015037116594612598,
-0.03343146666884422,
0.04768209904432297,
-0.007377695292234421,
0.025190984830260277,
0.022221125662326813,
-0.0012076060520485044,
0.024439716711640358,
-0.010306470096111298,
-0.0024460258428007364,
-0.016410529613494873,
-0.0042053451761603355,
-0.00753029715269804,
0.020554248243570328,
0.034957483410835266,
0.015013639815151691,
0.012231596745550632,
0.010130391456186771,
-0.022984134033322334,
-0.006743812467902899,
-0.027116112411022186,
-0.0004361614992376417,
0.043174486607313156,
-0.03469923138618469,
-0.027210021391510963,
0.027139589190483093,
-0.001688887714408338,
-0.012419413775205612,
-0.0063212234526872635,
-0.0063505698926746845,
0.0171970147639513,
0.006685119587928057,
-0.001995558151975274,
0.013663703575730324,
0.03847905620932579,
-0.0014673221157863736,
0.0009603623184375465,
0.025073599070310593,
-0.025120554491877556,
-0.0049683526158332825,
0.01082883682101965,
-0.01857042871415615,
0.009285214357078075,
0.017255708575248718,
-0.01891084760427475,
-0.012877218425273895,
-0.005828203167766333,
0.03681217506527901,
0.0440196618437767,
0.03448794037103653,
0.004974221810698509,
0.019556468352675438,
0.040075499564409256,
-0.007248571142554283,
-0.011280772276222706,
-0.02664656937122345,
-0.01509580947458744,
-0.03347842022776604,
-0.03228108584880829,
-0.016938766464591026,
0.006890544667840004,
0.013769350945949554,
-0.007594859227538109,
-0.033196695148944855,
0.004663149826228619,
-0.006714466027915478,
-0.015424489974975586,
-0.0077826762571930885,
-0.019932102411985397,
0.0012582286726683378,
-0.013828043825924397,
0.016281405463814735,
-0.04293971508741379,
-0.012982865795493126,
0.015142763964831829,
0.0056579941883683205,
0.007307264022529125,
0.03566179797053337,
0.0011342399520799518,
0.007101838942617178,
0.00907978881150484,
0.023817572742700577,
-0.014156723394989967,
0.016070110723376274,
-0.06367003917694092,
0.007195747457444668,
-0.005379202775657177,
-0.013041558675467968,
-0.010200823657214642,
-0.006825982592999935,
-0.035567887127399445,
-0.006520779337733984,
0.017478741705417633,
0.00348635739646852,
-0.017889590933918953,
0.00859850738197565,
-0.014919730834662914,
0.009120874106884003,
0.014520619064569473,
0.009414338506758213,
-0.04878552630543709,
0.02386452630162239,
0.01588229462504387,
0.020847711712121964,
0.017067890614271164,
0.0009992463747039437,
-0.04373793676495552,
0.014790606684982777,
-0.03324364870786667,
0.017138322815299034,
-0.017032675445079803,
0.013675441965460777,
-0.007407041732221842,
0.011944001540541649,
0.02843083254992962,
-0.013217637315392494,
0.004381423816084862,
-0.01272461749613285,
0.01015973836183548,
-0.003744605928659439,
-0.01272461749613285,
0.01760786585509777,
0.01236072089523077,
0.022174172103405,
-0.02393495850265026,
-0.012783310376107693,
-0.047705575823783875,
0.0073600877076387405,
-0.045029181987047195,
-0.026247458532452583,
0.020096443593502045,
0.006374047137796879,
-0.03352537378668785,
-0.010247777216136456,
0.007712244987487793,
0.0030901802238076925,
-0.01680964231491089,
0.0029713271651417017,
-0.016210975125432014,
-0.03730519860982895,
-0.033267125487327576,
-0.02341846004128456,
0.009643240831792355,
0.0007112844032235444,
0.02365323156118393,
0.007459865417331457,
0.04521699622273445,
-0.0440196618437767,
0.03664783760905266,
0.0027292191516608,
0.024463193491101265,
-0.009115004912018776,
-0.07137054949998856,
0.004657280165702105,
-0.0018400219269096851,
-0.004806946963071823,
0.007794415112584829,
0.019380390644073486,
-0.010030614212155342,
-0.043855324387550354,
0.036530449986457825,
-0.02011992037296295,
0.006467955652624369,
-0.008985880762338638,
-0.02648223005235195,
0.009578678756952286,
-0.027703041210770607,
0.0023932023905217648,
0.013464147225022316,
-0.015635784715414047,
-0.015905771404504776,
-0.026153549551963806,
-0.012830263935029507,
0.006708596833050251,
-0.012078995816409588,
-0.027116112411022186,
0.01175618451088667,
0.022056786343455315,
-0.037868648767471313,
-0.043620552867650986,
-0.003213435411453247,
0.015119287185370922,
-0.016563132405281067,
0.02049555443227291,
-0.004220018163323402,
0.010957960970699787,
0.034816619008779526,
-0.007095969747751951,
-0.0035832005087286234,
0.03664783760905266,
0.007166401017457247,
0.025871822610497475,
-0.007747460622340441,
-0.003462880151346326,
0.034957483410835266,
-0.026388321071863174,
0.004020462743937969,
-0.008281566202640533,
-0.009185436181724072,
0.011269033886492252,
-0.009878012351691723,
0.005144431255757809,
0.030848979949951172,
-0.011492067016661167,
0.004443051293492317,
0.00830504298210144,
-0.000019247139789513312,
0.014555835165083408,
-0.014391494914889336,
-0.015729693695902824,
-0.019486038014292717,
-0.010705581866204739,
-0.001966211711987853,
0.01739657111465931,
0.03413578122854233,
-0.015940986573696136,
-0.008293304592370987,
0.018300442025065422,
0.01476712990552187,
-0.027139589190483093,
-0.02641179785132408,
0.0017123648431152105,
0.053997453302145004,
-0.0012941780732944608,
0.010963831096887589,
0.011134039610624313,
-0.019579945132136345,
-0.027656087651848793,
0.011914655566215515,
0.004026331938803196,
-0.024228421971201897,
0.002303695771843195,
0.032609764486551285,
0.02589530125260353,
0.009367384016513824,
0.016269667074084282,
0.0006349836476147175,
0.007947016507387161,
-0.0029199710115790367,
-0.011803139001131058,
-0.014591051265597343,
-0.0319758839905262,
-0.018887370824813843,
-0.020918143913149834,
-0.03298540040850639,
0.02427537739276886,
-0.03124809078872204,
0.0031518079340457916,
0.016797903925180435,
0.0035567886661738157,
-0.00630948506295681,
0.007847238332033157,
-0.04209453612565994,
0.03476966544985771,
-0.0032369126565754414,
0.014602789655327797,
-0.02073032595217228,
-0.02901776134967804,
-0.02685786411166191,
0.0010520699433982372,
0.012689401395618916,
0.005904504097998142,
-0.05442004278302193,
0.011533151380717754,
0.020519033074378967,
-0.014144985005259514,
-0.008533945307135582,
0.04082677140831947,
0.006708596833050251,
0.013710658065974712,
-0.03502791374921799,
0.010112783871591091,
-0.007342479657381773,
0.028102152049541473,
-0.0031312652863562107,
-0.035192254930734634,
0.008545683696866035,
-0.01000713650137186,
0.002253806684166193,
-0.005587562453001738,
-0.03270367532968521,
0.006244922988116741,
-0.015800124034285545,
0.005065195728093386,
-0.01131011825054884,
-0.018664337694644928,
-0.003829710651189089,
0.01629314385354519,
-0.0378216952085495,
0.0025120554491877556,
-0.005065195728093386,
0.0034980957861989737,
0.01678616553544998,
0.045780450105667114,
-0.0035597234964370728,
0.016516176983714104,
0.007248571142554283,
0.009261736646294594,
-0.019439082592725754,
0.0023638559505343437,
0.01862912066280842,
-0.019521253183484077,
-0.020401647314429283,
0.003028552746400237,
-0.0016874204156920314,
-0.04301014542579651,
0.012208119966089725,
-0.0024709703866392374,
0.01339371595531702,
0.039887685328722,
-0.06554821133613586,
0.0023051630705595016,
-0.002290489850565791,
0.02678743191063404,
0.020683372393250465,
0.02568400651216507,
-0.039793774485588074,
0.025214463472366333,
-0.018006976693868637,
-0.0013499363558366895,
0.0026807973627001047,
-0.008052663877606392,
-0.04150760918855667,
0.004897921346127987,
0.016727471724152565,
0.022291557863354683,
0.030168142169713974,
0.007266179192811251,
-0.016703994944691658,
0.014356279745697975,
-0.03101331926882267,
-0.0038150374311953783,
0.01825348660349846,
-0.011251425370573997,
-0.015518398024141788,
0.04418400302529335,
0.021481595933437347,
-0.006884675472974777,
0.035638317465782166,
0.02523794025182724,
-0.009660848416388035,
-0.006010151468217373,
-0.031060274690389633,
-0.0071722702123224735,
-0.01509580947458744,
-0.009813450276851654,
0.12048475444316864,
-0.01712658256292343,
0.009913228452205658,
0.022702407091856003,
0.01966211572289467,
-0.006098190788179636,
0.006831851787865162,
-0.003492226591333747,
0.02208026312291622,
-0.013487624935805798,
0.026458751410245895,
-0.0007894192822277546,
0.018558690324425697,
0.004158390685915947,
0.0364365428686142,
-0.010423855856060982,
-0.0009728345321491361,
0.03819732740521431,
-0.016351837664842606,
0.010112783871591091,
0.0023066303692758083,
-0.005276490468531847,
-0.014943208545446396,
0.009285214357078075,
-0.030074233189225197,
-0.008774586021900177,
-0.0016756817931309342,
0.0021217477042227983,
-0.019169095903635025,
-0.0202842615544796,
0.026294412091374397,
0.026153549551963806,
0.015823600813746452,
-0.02155202627182007,
-0.004070351365953684,
-0.031482864171266556,
-0.015553614124655724,
-0.033267125487327576,
-0.006415131967514753,
-0.010869922116398811,
-0.005807660985738039,
-0.006344700697809458,
-0.011621191166341305,
-0.008651331067085266,
0.041108496487140656,
-0.008980011567473412,
-0.0027233497239649296,
0.020612940192222595,
0.019709071144461632,
-0.02915862388908863,
0.02258502133190632,
-0.008076140657067299,
0.011597713455557823,
-0.013851520605385303,
-0.021587243303656578,
-0.01064101979136467,
0.0005498789832927287,
-0.000977236544713378,
0.00018048062338493764,
-0.03958247974514961,
-0.020859450101852417,
0.002780575305223465,
0.025730960071086884,
-0.0008217003778554499,
0.00910913571715355
] | 2024-07-03 | 43 | 38959337 | [
"CAR T cells",
"cancer cells",
"immune cells",
"LIGHT-expressing CAR T cells",
"antigen-negative tumor cells",
"Chimeric antigen receptor",
"LIGHT",
"remarkable clinical success",
"target antigen heterogeneity",
"CAR",
"herpes virus entry mediator",
"solid tumors",
"antigen heterogeneity",
"B-cell malignancies",
"immunostimulatory properties",
"CAR) T-cell therapy",
"lymphotoxin",
"antigen-negative disease relapse",
"cytolytic profile",
"the cells proliferation",
"antigen-independent killing",
"its clinical efficacy",
"the CAR",
"both antigen-directed cytotoxicity",
"β receptor",
"both lymphotoxin",
"the treatment",
"a way",
"the interaction",
"a ligand"
] | [] | 0 | 10.1158/2326-6066.CIR-24-0246
10.1126/scitranslmed.3005930
10.1038/s41571-019-0184-6
10.1038/s41598-017-10940-8
10.1172/JCI13827
10.1016/s1074-7613(00)80455-0
10.1111/j.1600-065X.2011.01064.x
10.1182/blood-2006-09-047332
10.1073/pnas.1411072112
10.1084/jem.20012088
10.4049/jimmunol.164.8.4105
10.1182/blood-2005-08-3485
10.1074/jbc.275.19.14307
10.1002/path.5080
10.1038/sj.cr.7290210
10.1038/ni1029
10.3389/fimmu.2014.00047
10.1073/pnas.92.15.6733
10.1007/978-1-59745-409-4_7
10.1186/s13059-018-1603-1
10.1186/s13059-019-1874-1
10.1016/j.cell.2019.05.031
10.1016/j.cell.2021.04.048
10.1093/nar/gkz446
10.1126/science.aad0501
10.1158/2159-8290.CD-15-0583
10.1126/scitranslmed.3010162
10.1158/2159-8290.CD-18-0442
10.1038/nature12626
10.4049/jimmunol.179.3.1960
10.1038/cmi.2010.15
10.1002/pros.22914
10.1038/ni.3836
10.1016/j.ccell.2016.02.004
10.1038/nbt.4195
10.1038/s41589-021-00932-1
10.1172/JCI166028
10.1016/j.ccell.2018.08.007
10.1038/s41586-022-04494-7
10.1073/pnas.0701959104
10.1016/j.celrep.2015.12.004
10.1016/j.ccell.2023.04.010
10.1016/j.ymthe.2023.06.015 | [
"Cai",
"Tanaka",
"Mi",
"Rajasekhar",
"Khan",
"Yoo",
"de Stanchina",
"Rahman",
"Mathew",
"Abrahimi",
"Souness",
"Purdon",
"McDowell",
"Meyerberg",
"Fujino",
"Healey",
"Abdel-Wahab",
"Scheinberg",
"Brentjens",
"Daniyan"
] | [
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.\nPharmacology Program, Weill Cornell Medical College, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Pharmacology Program, Weill Cornell Medical College, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Pharmacology Program, Weill Cornell Medical College, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Roswell Park Comprehensive Cancer Center, Buffalo, New York.",
"Roswell Park Comprehensive Cancer Center, Buffalo, New York.",
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York.",
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.\nPharmacology Program, Weill Cornell Medical College, New York, New York.",
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.\nPharmacology Program, Weill Cornell Medical College, New York, New York.",
"Roswell Park Comprehensive Cancer Center, Buffalo, New York.",
"Memorial Sloan Kettering Cancer Center, New York, New York."
] | [
"38959337",
"23515080",
"30837712",
"28874817",
"11748260",
"9462508",
"22017438",
"17179227",
"25512551",
"11901205",
"10754304",
"16223768",
"10799510",
"29603739",
"15115612",
"14704792",
"24575096",
"7624312",
"19110621",
"30567574",
"31870423",
"31178118",
"34062119",
"31114921",
"27124452",
"26503962",
"25378643",
"30135176",
"24048067",
"17641063",
"20418899",
"25399517",
"28892469",
"26977880",
"30102295",
"34969970",
"36951942",
"30205048",
"35296855",
"17652173",
"26711337",
"37172581",
"37408308"
] | [] | 9.069549 | 4.873867 |
38957786 | 779 | CAR T cells redirected to B7-H3 for pediatric solid tumors: Current status and future perspectives. | Despite intensive therapies, pediatric patients with relapsed or refractory solid tumors have poor outcomes and need novel treatments. Immune therapies offer an alternative to conventional treatment options but require the identification of differentially expressed antigens to direct antitumor activity to sites of disease. B7-H3 (CD276) is an immune regulatory protein that is expressed in a range of malignancies and has limited expression in normal tissues. B7-H3 is highly expressed in pediatric solid tumors including osteosarcoma, rhabdomyosarcoma, Ewing sarcoma, Wilms tumor, neuroblastoma, and many rare tumors. In this article we review B7-H3-targeted chimeric antigen receptor (B7-H3-CAR) T cell therapies for pediatric solid tumors, reporting preclinical development strategies and outlining the landscape of active pediatric clinical trials. We identify challenges to the success of CAR T cell therapy for solid tumors including localizing to and penetrating solid tumor sites, evading the hostile tumor microenvironment, supporting T cell expansion and persistence, and avoiding intrinsic tumor resistance. We highlight strategies to overcome these challenges and enhance the effect of B7-H3-CAR T cells, including advanced CAR T cell design and incorporation of combination therapies. | [
-0.012700903229415417,
0.01138600055128336,
0.0683513805270195,
0.05731327086687088,
-0.04441188648343086,
-0.03299640491604805,
-0.008938983082771301,
0.031416162848472595,
0.014304731972515583,
-0.016109038144350052,
-0.016415651887655258,
-0.020967693999409676,
-0.008243205025792122,
0.01115603931248188,
0.016144417226314545,
0.01575525291264057,
0.06891743838787079,
0.013314131647348404,
0.008319858461618423,
0.006686548236757517,
0.04839787259697914,
-0.003077934728935361,
-0.012099468149244785,
0.012441460974514484,
-0.015236367471516132,
0.0006703500403091311,
0.040567416697740555,
-0.008673643693327904,
0.008142965845763683,
-0.01747700944542885,
0.04096837341785431,
-0.008154758252203465,
-0.03294923156499863,
-0.02490650676190853,
-0.017406251281499863,
0.015318917110562325,
-0.005415868014097214,
0.042666543275117874,
-0.014210388995707035,
-0.0025767385959625244,
0.028350019827485085,
0.005303835961967707,
0.018467608839273453,
0.06547392159700394,
-0.03660501912236214,
0.01609724573791027,
-0.01298393215984106,
-0.03502477705478668,
0.015601945109665394,
-0.001235301373526454,
-0.003714748891070485,
0.004557937849313021,
0.018514780327677727,
0.04582703113555908,
-0.031203890219330788,
0.0528319850564003,
-0.01727653108537197,
0.015307123772799969,
-0.010289264842867851,
0.004905827343463898,
0.003128054551780224,
-0.005380489397794008,
-0.020944107323884964,
-0.01484720315784216,
-0.048445042222738266,
0.02066108025610447,
-0.08316320180892944,
-0.05528489872813225,
-0.01785438135266304,
0.009835240431129932,
-0.009522729553282261,
-0.032241661101579666,
0.002828810829669237,
0.002883352804929018,
0.05269046872854233,
-0.017583144828677177,
0.028963249176740646,
-0.0023394073359668255,
-0.0033462222199887037,
-0.038090918213129044,
0.01573166623711586,
-0.018927529454231262,
0.032336004078388214,
-0.035166289657354355,
-0.029293449595570564,
0.00862057600170374,
0.024576306343078613,
-0.025448977947235107,
-0.01678123138844967,
-0.004855707753449678,
0.015130231156945229,
-0.0018544262275099754,
-0.048680901527404785,
0.06283232569694519,
-0.0013908196706324816,
-0.005878737661987543,
-0.026392405852675438,
-0.04976584389805794,
0.03226524963974953,
0.0068044764921069145,
0.0036086132749915123,
0.012818831950426102,
-0.03766637668013573,
-0.012618353590369225,
0.022276701405644417,
0.001733549521304667,
-0.03252469003200531,
0.0006205989047884941,
0.008260893635451794,
-0.0020843870006501675,
0.05108664184808731,
0.009852929040789604,
-0.014458038844168186,
0.04323260113596916,
-0.03325584903359413,
-0.04651101678609848,
-0.04587420076131821,
-0.02148658037185669,
0.00046544920769520104,
0.055237725377082825,
-0.015884973108768463,
0.060285069048404694,
0.010837632231414318,
-0.05674721300601959,
0.026958463713526726,
-0.01984737254679203,
0.09439000487327576,
0.0055249519646167755,
-0.019564343616366386,
-0.06901177763938904,
0.010743290185928345,
0.0015890870708972216,
0.009905996732413769,
-0.014528796076774597,
-0.04429395869374275,
0.006603998132050037,
0.011444964446127415,
-0.029906677082180977,
-0.015932144597172737,
-0.00903922226279974,
0.014776445925235748,
0.018290715292096138,
-0.021993672475218773,
-0.026510335505008698,
-0.019576137885451317,
-0.033515289425849915,
-0.014410867355763912,
0.03860980272293091,
0.019352072849869728,
0.04000135883688927,
-0.002371837617829442,
0.026392405852675438,
0.04533173143863678,
0.026463164016604424,
0.0006570830591954291,
-0.045968543738126755,
0.0016288879560306668,
0.04059100151062012,
-0.03278413414955139,
-0.03007177636027336,
-0.045732688158750534,
0.028821734711527824,
-0.02417534962296486,
-0.024599893018603325,
0.03214731812477112,
0.00045992128434590995,
-0.008142965845763683,
0.01274807471781969,
-0.06585129350423813,
0.026439577341079712,
0.00709929782897234,
-0.019045459106564522,
-0.04566192999482155,
0.0037678168155252934,
-0.02385694347321987,
-0.009882410988211632,
0.014422659762203693,
0.008632369339466095,
-0.00921611487865448,
-0.018373265862464905,
0.014988716691732407,
0.029151935130357742,
0.01597931608557701,
0.009852929040789604,
0.027453763410449028,
0.043397702276706696,
-0.022618694230914116,
0.01543684583157301,
-0.04441188648343086,
0.010472053661942482,
0.023172957822680473,
-0.019434623420238495,
0.05976618453860283,
-0.010814046487212181,
0.03960040211677551,
-0.016851987689733505,
0.030354805290699005,
0.008290376514196396,
-0.02500084973871708,
-0.03983626142144203,
-0.004154032561928034,
-0.01879780925810337,
-0.027524519711732864,
-0.024717820808291435,
-0.029859505593776703,
-0.025425393134355545,
-0.019328488036990166,
0.02382156439125538,
0.003110365243628621,
-0.010536914691329002,
0.02043701522052288,
0.008821054361760616,
-0.007482565473765135,
0.02021295204758644,
-0.029788749292492867,
-0.013939153403043747,
-0.002965902676805854,
0.021698851138353348,
0.033185090869665146,
0.023562122136354446,
-0.008909501135349274,
0.013078275136649609,
-0.028798148036003113,
0.03313791751861572,
-0.0016568959690630436,
0.009599382989108562,
0.018337886780500412,
-0.05353955551981926,
-0.018031273037195206,
-0.007276190910488367,
0.025448977947235107,
0.007759697735309601,
0.032477520406246185,
-0.018278922885656357,
-0.036345575004816055,
0.01796051673591137,
-0.027406591922044754,
0.000771694874856621,
0.03797299042344093,
-0.02853870578110218,
-0.00147558085154742,
-0.0067632016725838184,
-0.019293108955025673,
0.01444624550640583,
0.002685822546482086,
0.0025369375944137573,
0.007223122753202915,
-0.05556792765855789,
0.012205603532493114,
-0.03219449147582054,
0.005675310734659433,
-0.00927507970482111,
-0.0009286872227676213,
-0.009782171808183193,
0.012901381589472294,
0.005118098575621843,
0.053822584450244904,
0.014281146228313446,
-0.0003681581583805382,
-0.044223200529813766,
-0.025448977947235107,
-0.002557575237005949,
-0.011987435631453991,
-0.07184206694364548,
-0.059954866766929626,
0.02325550839304924,
-0.000340150116244331,
-0.0024411207996308804,
0.03441154584288597,
-0.028515120968222618,
0.04613364487886429,
0.004681762773543596,
0.03945888951420784,
-0.016627924516797066,
-0.00760049419477582,
0.012901381589472294,
-0.008414201438426971,
0.03110954724252224,
0.006085112690925598,
0.022052636370062828,
-0.010814046487212181,
0.02877456322312355,
-0.03101520612835884,
-0.013243374414741993,
-0.0027388902381062508,
0.020602116361260414,
0.02783113531768322,
0.007317465730011463,
-0.05316218361258507,
0.012665525078773499,
0.03415210545063019,
-0.010507432743906975,
-0.01901008002460003,
-0.028515120968222618,
-0.019894544035196304,
0.008844640105962753,
0.020224744454026222,
-0.059483155608177185,
-0.023797979578375816,
0.04603930190205574,
-0.06023789569735527,
0.009499143809080124,
-0.0300481915473938,
-0.026227306574583054,
0.016828402876853943,
0.033397361636161804,
0.050190385431051254,
-0.007140573114156723,
0.026274478062987328,
0.028585877269506454,
0.041487257927656174,
-0.014316524378955364,
-0.007199537009000778,
0.016403859481215477,
0.008673643693327904,
-0.016863780096173286,
0.010572293773293495,
-0.008060415275394917,
-0.02759527787566185,
-0.020637493580579758,
-0.01971765235066414,
-0.02326730079948902,
-0.07948383688926697,
0.02641599252820015,
-0.03136898949742317,
-0.059954866766929626,
0.017465217038989067,
0.005336266476660967,
0.023455986753106117,
-0.05108664184808731,
0.014752860181033611,
-0.0415344312787056,
0.04368073120713234,
-0.04125140234827995,
0.03368039056658745,
-0.029317034408450127,
0.025802763178944588,
-0.02347957156598568,
-0.014953338541090488,
0.041510846465826035,
-0.00127731345128268,
-0.008113482967019081,
-0.027312248945236206,
0.032807718962430954,
-0.012382496148347855,
-0.014717481099069118,
-0.01437548827379942,
0.02830284833908081,
0.009894204325973988,
0.055379241704940796,
0.026581091806292534,
0.008997946977615356,
0.041039131581783295,
0.0029983329586684704,
0.0057784984819591045,
0.003458254272118211,
-0.025897106155753136,
-0.04577985778450966,
0.017547765746712685,
0.021781401708722115,
0.005106305703520775,
-0.01713501662015915,
-0.03625123202800751,
0.04886958748102188,
0.04615722969174385,
0.05004887282848358,
-0.008549818769097328,
0.01544863823801279,
-0.03936454653739929,
-0.027760377153754234,
-0.05575661361217499,
0.006934198085218668,
0.03099161945283413,
-0.0239630788564682,
-0.01786617375910282,
0.027878306806087494,
0.0008439261000603437,
0.01737087406218052,
-0.01853836514055729,
0.045968543738126755,
0.05259612947702408,
0.006138180382549763,
-0.010206715203821659,
-0.02406921423971653,
0.0028789304196834564,
0.0057637570425868034,
0.03028404898941517,
-0.03554366156458855,
-0.03733617439866066,
0.026864120736718178,
0.03297282010316849,
0.021274307742714882,
0.030968034639954567,
-0.009086393751204014,
-0.0020976539235562086,
0.06250212341547012,
-0.012205603532493114,
0.06561543792486191,
0.04070892930030823,
0.0025516788009554148,
-0.005796187557280064,
-0.06203041225671768,
-0.010996836237609386,
-0.022972479462623596,
-0.009487350471317768,
-0.03901075944304466,
0.027689620852470398,
0.01607365906238556,
0.01691095158457756,
-0.03981267288327217,
-0.021899329498410225,
-0.014021703042089939,
0.029151935130357742,
0.027783963829278946,
0.009428386576473713,
-0.02009502239525318,
-0.034694574773311615,
0.06014355272054672,
-0.017889758571982384,
0.032218076288700104,
0.013219788670539856,
-0.04231275990605354,
0.01855015940964222,
-0.03087369166314602,
0.015248159877955914,
-0.02596786431968212,
0.03877490386366844,
-0.00375897204503417,
0.005961287766695023,
-0.025661250576376915,
-0.014116046018898487,
0.0673607811331749,
-0.0219465009868145,
-0.017819002270698547,
-0.004162877332419157,
-0.03467098996043205,
-0.047383684664964676,
0.0504734143614769,
-0.022807378321886063,
0.05740761011838913,
-0.02314937114715576,
0.037760715931653976,
0.0019723547156900167,
-0.01889215223491192,
0.006444794591516256,
-0.0131608247756958,
0.05094512924551964,
0.05764346942305565,
-0.03488326072692871,
-0.030850104987621307,
0.0019590877927839756,
-0.039765503257513046,
0.006185351870954037,
0.01783079467713833,
0.012441460974514484,
-0.006556826643645763,
0.047855399549007416,
-0.054011270403862,
-0.023904114961624146,
0.0020608012564480305,
0.05188855528831482,
0.00862647220492363,
0.009369422681629658,
-0.03155767545104027,
-0.027524519711732864,
0.017335494980216026,
0.031746361404657364,
-0.0033462222199887037,
0.01607365906238556,
-0.06396444141864777,
0.026015035808086395,
-0.05023755505681038,
0.001936976215802133,
-0.01584959588944912,
-0.01656895875930786,
0.060992639511823654,
-0.011604168452322483,
0.012099468149244785,
0.00844957958906889,
0.0026342286728322506,
0.014316524378955364,
0.02197008579969406,
-0.07080429047346115,
-0.024104593321681023,
0.06396444141864777,
-0.016415651887655258,
-0.04486001655459404,
0.026038620620965958,
-0.03957681730389595,
0.08146503567695618,
-0.014752860181033611,
-0.013432060368359089,
-0.004546144977211952,
-0.010855321772396564,
-0.005628139246255159,
-0.023786185309290886,
-0.006792683620005846,
-0.019316693767905235,
-0.018137408420443535,
0.029269862920045853,
-0.03379831835627556,
0.02217056415975094,
0.018738845363259315,
0.03276054933667183,
0.06302101165056229,
0.03030763380229473,
0.009752689860761166,
0.0406617596745491,
0.01226456742733717,
0.02055494487285614,
-0.030449148267507553,
-0.026722606271505356,
0.013561781495809555,
0.0010362970642745495,
-0.03007177636027336,
-0.05320935696363449,
-0.0406617596745491,
-0.034364376217126846,
-0.009929582476615906,
0.011663132347166538,
-0.02478857897222042,
0.02184036560356617,
-0.0014357799664139748,
0.009764483198523521,
-0.00038326773210428655,
-0.036581430584192276,
-0.02901042066514492,
-0.0528319850564003,
-0.02088514342904091,
-0.05674721300601959,
0.022347457706928253,
-0.02608579210937023,
0.022583315148949623,
0.015106645412743092,
-0.028208505362272263,
0.01630951650440693,
-0.04108630120754242,
0.02547256462275982,
-0.015790631994605064,
-0.03547290340065956,
-0.012512218207120895,
-0.006497862283140421,
0.018361473456025124,
0.023644670844078064,
0.01689915917813778,
0.024458378553390503,
0.022241322323679924,
0.0029806438833475113,
0.009528625756502151,
-0.009900100529193878,
0.04981301352381706,
-0.025873521342873573,
0.015566566959023476,
0.002062275307253003,
0.00012677317135967314,
-0.0004938257625326514,
-0.0006368141039274633,
-0.030024604871869087,
0.013774053193628788,
0.011073489673435688,
-0.030496319755911827,
-0.014481624588370323,
0.017535973340272903,
-0.020036058500409126,
-0.008313962258398533,
0.011698510497808456,
0.0005269931280054152,
-0.008579300716519356,
-0.030590662732720375,
0.04287881776690483,
-0.019694065675139427,
0.013703295961022377,
-0.00945786852389574,
-0.04771388694643974,
0.04790257290005684,
-0.020932314917445183,
-0.020260123535990715,
0.006869337521493435,
-0.013620746321976185,
0.0043161846697330475,
-0.02735942043364048,
-0.021521957591176033,
-0.005424712784588337,
0.030920863151550293,
0.004239530768245459,
0.010442571714520454,
-0.011279864236712456,
0.008066312409937382,
-0.020696457475423813,
-0.0013849232345819473,
0.029293449595570564,
-0.02431686408817768,
0.02559049241244793,
0.0020755422301590443,
-0.027783963829278946,
0.02135685831308365,
-0.015059473924338818,
-0.021321479231119156,
-0.026463164016604424,
-0.011273968033492565,
0.02618013508617878,
-0.005984873045235872,
0.0050561861135065556,
-0.026958463713526726,
-0.032925646752119064,
0.05731327086687088,
0.009092289954423904,
-0.0359446182847023,
0.023279093205928802,
0.024246107786893845,
0.02712356299161911,
0.04129857197403908,
-0.03158126398921013,
0.0162033811211586,
0.01843222975730896,
0.013927360065281391,
-0.024623477831482887,
-0.021580921486020088,
0.007942486554384232,
-0.0007311569061130285,
-0.0010200818069279194,
0.0035142702981829643,
-0.023172957822680473,
0.022111600264906883,
-0.026132963597774506,
-0.03842111676931381,
-0.003776661353185773,
0.006633480079472065,
0.030708590522408485,
0.003708852455019951,
-0.008378822356462479,
-0.058869924396276474,
-0.02830284833908081,
0.0028317589312791824,
-0.005563278682529926,
-0.04448264464735985,
-0.00011193998216185719,
-0.015601945109665394,
-0.024010250344872475,
-0.0030985723715275526,
-0.012712696567177773,
0.020236536860466003,
-0.0066924444399774075,
-0.031769946217536926,
0.013691503554582596,
-0.014575967565178871,
-0.03028404898941517,
0.012476839125156403,
-0.019198765978217125,
-0.03254827484488487,
-0.0032784133218228817,
-0.013526403345167637,
0.014587759971618652,
-0.0012846840545535088,
0.012818831950426102,
-0.03391624614596367,
-0.003602716838940978,
-0.01204640045762062,
0.043256185948848724,
0.05561509728431702,
-0.010955560952425003,
0.014705688692629337,
-0.012995724566280842,
-0.0384918749332428,
0.019823787733912468,
0.0021905226167291403,
0.027878306806087494,
-0.011421378701925278,
0.011291657574474812,
0.003782557789236307,
0.08410663157701492,
-0.008349340409040451,
0.035425733774900436,
-0.029859505593776703,
0.006332762539386749,
0.0028863009065389633,
0.006149973254650831,
0.005445350427180529,
-0.05849255621433258,
-0.002629806287586689,
-0.010996836237609386,
-0.009434282779693604,
-0.014882581308484077,
-0.06259647011756897,
-0.000753268541302532,
0.02230028621852398,
-0.006545033771544695,
-0.002737416187301278,
0.008249101229012012,
0.007158262189477682,
0.023090407252311707,
-0.018868565559387207,
-0.008856433443725109,
-0.013455646112561226,
0.006509655155241489,
0.023397020995616913,
0.00904511846601963,
-0.02549614943563938,
-0.031085962429642677,
-0.08665388822555542,
0.02794906310737133,
0.005866944789886475,
0.043727900832891464,
-0.06302101165056229,
0.022618694230914116,
-0.005822721403092146,
-0.002385104773566127,
0.0006069634691812098,
0.00973500031977892,
0.04849221557378769,
-0.008367029950022697,
0.008555714972317219,
-0.007400015834718943,
-0.04167594388127327,
0.002009207382798195,
0.005716586019843817,
-0.009139461442828178,
0.037737131118774414,
0.003785506123676896,
0.025779178366065025,
0.01607365906238556,
0.005486625246703625,
0.000826236791908741,
-0.01028336863964796,
0.03448230400681496,
0.02759527787566185,
-0.060520924627780914,
0.04665252938866615,
-0.029434962198138237,
-0.010766874998807907,
-0.01239428948611021,
0.02009502239525318,
-0.04684121534228325,
-0.03368039056658745,
0.004304391797631979,
0.02441120706498623,
-0.02875097654759884,
-0.010843529365956783,
-0.013349510729312897,
-0.011492135934531689,
0.026015035808086395,
-0.025873521342873573,
-0.01915159448981285,
-0.005920012481510639,
-0.006214833818376064,
0.03294923156499863,
0.02241821587085724,
-0.0026578144170343876,
0.011250382289290428,
-0.023680049926042557,
0.052313100546598434,
0.007989658042788506,
-0.022701242938637733,
0.005006066523492336,
0.010542810894548893,
0.00010281894356012344,
0.0041569811291992664,
0.011893092654645443,
-0.01761852391064167,
-0.039175860583782196,
-0.00590232340618968,
0.028916077688336372,
-0.017889758571982384,
0.008543922565877438,
-0.012358910404145718,
0.018373265862464905,
0.00498837698251009,
0.011173728853464127,
0.004360407590866089,
-0.000659662764519453,
-0.01021261140704155,
-0.015047681517899036,
0.010513328947126865,
-0.031746361404657364,
-0.010442571714520454,
0.029741577804088593,
-0.05835103988647461,
0.003464150708168745,
-0.007706630043685436,
-0.0004363355983514339,
-0.015932144597172737,
0.004071482922881842,
0.008160654455423355,
0.019316693767905235,
-0.0219465009868145,
0.0009272131137549877,
0.028137749060988426,
0.040826860815286636,
-0.039977774024009705,
-0.003307895502075553,
-0.007352844346314669,
0.03839753195643425,
-0.016863780096173286,
0.015908559784293175,
0.007948383688926697,
-0.0022951841820031404,
0.05509621277451515,
-0.07085146754980087,
-0.0018942271126434207,
0.00968782976269722,
-0.02969440631568432,
-0.010436675511300564,
-0.013337717391550541,
-0.016722267493605614,
0.005819773301482201,
0.00921021867543459,
-0.013939153403043747,
0.016262345016002655,
-0.03273696079850197,
0.02948213368654251,
0.005784394685178995,
-0.0066688586957752705,
-0.05457732826471329,
-0.0048262253403663635,
-0.05967184156179428,
-0.03250110521912575,
0.006503758952021599,
0.014493416994810104,
0.015130231156945229,
0.01044846884906292,
0.02910476364195347,
-0.013101860880851746,
0.04766671359539032,
-0.013443853706121445,
0.009964961558580399,
-0.0347653329372406,
-0.05698306858539581,
-0.010165439918637276,
0.028232092037796974,
-0.011904885992407799,
0.03559083119034767,
-0.0034523578360676765,
-0.02559049241244793,
0.014458038844168186,
0.0025428340304642916,
0.000648975488729775,
0.00777738681063056,
0.0234677791595459,
-0.011928471736609936,
0.023868735879659653,
0.019069043919444084,
-0.03518987447023392,
-0.010259782895445824,
-0.019458208233118057,
-0.004664073698222637,
0.0022096859756857157,
-0.015366088598966599,
0.010265679098665714,
-0.03231241926550865,
-0.034340791404247284,
-0.004790846724063158,
0.032925646752119064,
-0.030567076057195663,
0.012842417694628239,
0.008526233024895191,
0.011551099829375744,
-0.0005104094743728638,
-0.030142534524202347,
0.025543320924043655,
0.02842077799141407,
-0.0001113871912821196,
-0.008549818769097328,
-0.006034993100911379,
-0.013101860880851746,
0.03099161945283413,
-0.04896393045783043,
0.041510846465826035,
-0.014552381820976734,
0.019340280443429947,
-0.0683513805270195,
0.026109378784894943,
0.020755423232913017,
0.003036659909412265,
-0.012123053893446922,
0.009145357646048069,
0.0026209617499262094,
0.020036058500409126,
-0.010554604232311249,
-0.012034607119858265,
-0.035166289657354355,
0.036109719425439835,
-0.03337377682328224,
-0.0035142702981829643,
0.023632878437638283,
0.02500084973871708,
0.007694837171584368,
-0.0026681332383304834,
-0.02359750121831894,
-0.017453422769904137,
-0.00354964891448617,
0.012618353590369225,
0.008207825943827629,
-0.02995384857058525,
-0.005878737661987543,
-0.0027197268791496754,
0.02217056415975094,
-0.0002445174613967538,
0.05726609751582146,
-0.0335860475897789,
0.0069224052131175995,
-0.0224418006837368,
-0.0035761829931288958,
-0.0029231535736471415,
0.02372722141444683,
-0.01274807471781969,
-0.03710031881928444,
-0.024576306343078613,
0.0189039446413517,
0.01108528207987547,
0.03030763380229473,
0.00396239897236228,
0.023880528286099434,
0.018337886780500412,
0.03160484880208969,
-0.01842043735086918,
0.010772772133350372,
-0.003573234658688307,
0.05023755505681038,
0.01527174562215805,
0.05052058398723602,
0.021875742822885513,
-0.028680220246315002,
-0.008131172508001328,
-0.006185351870954037,
0.015354295261204243,
0.011161936447024345,
0.007913004606962204,
0.0005973817314952612,
0.03853904455900192,
-0.006586308591067791,
-0.020448807626962662,
-0.00329020619392395,
0.03443513438105583,
-0.015542981214821339,
0.03405776247382164,
0.022736622020602226,
-0.0006246527191251516,
0.004725986160337925,
-0.009876514784991741,
-0.0059937178157269955,
0.01132703572511673,
0.013750467449426651,
0.002150721615180373,
-0.03344453498721123,
0.010306954383850098,
0.012347117997705936,
-0.014068874530494213,
-0.02123892866075039,
0.02358570694923401,
0.03325584903359413,
0.02865663543343544,
0.026486748829483986,
0.016226965934038162,
0.004711245186626911,
-0.022276701405644417,
-0.02243000827729702,
0.023102199658751488,
-0.057596296072006226,
0.053020671010017395,
-0.024953678250312805,
-0.0312274768948555,
0.00502080749720335,
-0.01807844452559948,
0.019069043919444084,
0.01971765235066414,
0.03733617439866066,
0.017170395702123642,
0.004065586254000664,
-0.04943564161658287,
0.03226524963974953,
-0.013726881705224514,
-0.005014910828322172,
0.009646554477512836,
0.0005815351032651961,
0.027217905968427658,
0.012465046718716621,
0.009363525547087193,
0.0011424326803535223,
-0.008750297129154205,
0.018255338072776794,
-0.010902493260800838,
0.022029051557183266,
-0.006745512131601572,
-0.006592205259948969,
-0.013809431344270706,
0.06141718104481697,
-0.007122883573174477,
-0.02618013508617878,
-0.02995384857058525,
0.01959972269833088,
0.043043915182352066,
0.05368107184767723,
-0.015684494748711586,
-0.0401664599776268,
0.005398178938776255,
-0.037029560655355453,
-0.004159929230809212,
-0.00938711129128933,
-0.0024647065438330173,
0.04224200174212456,
-0.005065030883997679,
-0.045968543738126755,
0.016875574365258217,
0.040355145931243896,
-0.039057932794094086,
-0.01726473867893219,
0.07783283293247223,
-0.018998287618160248,
0.04125140234827995,
-0.012901381589472294,
0.014186803251504898,
0.008113482967019081,
0.0056841555051505566,
0.006934198085218668,
-0.006497862283140421,
-0.03934096172451973,
-0.003487736452370882,
-0.006279694382101297,
-0.04429395869374275,
-0.001808728906325996,
-0.010855321772396564,
0.00997085776180029,
0.0123235322535038,
0.015542981214821339,
0.020720044150948524,
-0.008738504722714424,
0.020472394302487373,
-0.025802763178944588,
0.009257390163838863,
0.011486239731311798,
0.019528966397047043,
-0.0044311648234725,
0.018396852537989616,
-0.00027049859636463225,
-0.02665184997022152,
-0.00963476113975048,
-0.02570842206478119,
0.05778498202562332,
-0.003304947167634964,
-0.009322251193225384,
-0.03132181987166405,
-0.020967693999409676,
-0.01426935289055109,
0.0575491264462471,
-0.058775581419467926,
0.00016509994748048484,
-0.0158613882958889,
-0.01215843204408884,
0.012712696567177773,
0.026958463713526726,
0.0288689061999321,
0.02816133387386799,
0.020413430407643318,
0.006999058648943901,
0.010749186389148235,
0.02184036560356617,
-0.006397623103111982,
0.01544863823801279,
-0.027335835620760918,
-0.024222521111369133,
0.011999228969216347,
0.031534090638160706,
0.017642108723521233,
0.007246708497405052,
-0.008944879285991192,
0.003063193755224347,
0.022807378321886063,
0.018125616014003754,
-0.005890530534088612,
-0.007907108403742313,
-0.017936930060386658,
-0.015366088598966599,
-0.02714714966714382,
0.01832609437406063,
-0.016368480399250984,
0.04684121534228325,
-0.025401806458830833,
0.00838471855968237,
-0.00003724422640516423,
0.00039174387347884476,
0.025213120505213737,
0.018632708117365837,
-0.004566782619804144,
-0.02971799112856388,
-0.010112372227013111,
0.010996836237609386,
-0.02088514342904091,
-0.02523670718073845,
0.021179964765906334,
0.014410867355763912,
-0.007883522659540176,
-0.006769097875803709,
-0.031085962429642677,
-0.013833017088472843,
-0.03332660347223282,
-0.00489993067458272,
-0.006857544649392366,
-0.017771830782294273,
0.048680901527404785,
-0.014764652587473392,
-0.028798148036003113,
0.007453083526343107,
-0.012559388764202595,
-0.015354295261204243,
-0.025802763178944588,
0.038208846002817154,
-0.009168943390250206,
-0.02629806473851204,
0.03566158935427666,
0.0396711602807045,
0.015943938866257668,
0.013620746321976185,
0.014552381820976734,
-0.0182199589908123,
0.011262175627052784,
0.0182199589908123,
-0.00014823985111434013,
0.011427274905145168,
0.025307463482022285,
0.004699452314525843,
-0.023055028170347214,
-0.03353887423872948,
-0.003641043556854129,
0.022264907136559486,
-0.014469831250607967,
-0.02220594324171543,
-0.03872773051261902,
-0.02300785854458809,
-0.0020165781024843454,
0.013467438519001007,
0.0036351471208035946,
-0.0011284287320449948,
0.0123235322535038,
0.018809601664543152,
0.007470773067325354,
0.01713501662015915,
0.03160484880208969,
-0.00536869652569294,
0.004997221753001213,
0.011580582708120346,
0.012182017788290977,
0.03981267288327217,
-0.0051918039098382,
-0.0018072548555210233,
-0.009658346883952618,
-0.016403859481215477,
-0.01915159448981285,
0.04766671359539032,
-0.02114458754658699,
-0.051369670778512955,
0.02971799112856388,
0.006869337521493435,
-0.011332932859659195,
-0.0005424712435342371,
-0.013420267961919308,
-0.016816608607769012,
-0.0018367369193583727,
0.005392282269895077,
0.030472734943032265,
-0.0024101645685732365,
-0.018998287618160248,
0.012889589183032513,
-0.008738504722714424,
0.0055485377088189125,
0.010825839824974537,
0.0059701320715248585,
-0.0018470557406544685,
-0.008956672623753548,
0.03160484880208969,
-0.025661250576376915,
-0.002988014370203018,
-0.023043235763907433,
0.0180666521191597,
0.04646384343504906,
0.03603896126151085,
-0.008172447793185711,
0.02948213368654251,
-0.017524180933833122,
-0.008502647280693054,
0.0017866173293441534,
-0.005751964636147022,
-0.0023998457472771406,
-0.021309686824679375,
-0.04212407395243645,
-0.01725294440984726,
0.007718422915786505,
0.0006342343986034393,
-0.009369422681629658,
0.015943938866257668,
0.04165235906839371,
-0.004419371951371431,
0.0019399244338274002,
-0.0504734143614769,
0.010849425569176674,
0.00833754800260067,
-0.0016200433019548655,
0.009334043599665165,
-0.02112100087106228,
0.007712526246905327,
0.017418045550584793,
-0.003732438199222088,
-0.008526233024895191,
0.03075576201081276,
0.0010222929995507002,
0.038208846002817154,
0.005940650124102831,
-0.011922575533390045,
-0.006102801766246557,
-0.009964961558580399,
-0.05976618453860283,
0.03276054933667183,
0.003077934728935361,
0.013455646112561226,
-0.008679539896547794,
0.0004098016652278602,
-0.02759527787566185,
0.004044948611408472,
0.015366088598966599,
0.011940264143049717,
0.022276701405644417,
0.014316524378955364,
-0.018243543803691864,
-0.0034553061705082655,
-0.001957613741979003,
0.004068534355610609,
-0.015578359365463257,
0.020613908767700195,
0.013302339240908623,
0.016981709748506546,
-0.012712696567177773,
-0.012182017788290977,
-0.0025325154419988394,
-0.017925137653946877,
0.012594767846167088,
0.0045726788230240345,
-0.0001700750581221655,
-0.006149973254650831,
0.0071051944978535175,
0.02853870578110218,
0.026156550273299217,
0.014870788902044296,
0.021804986521601677,
-0.0300481915473938,
0.004033156204968691,
-0.013726881705224514,
0.009935479611158371,
0.022123394533991814,
-0.001123269321396947,
0.005872840993106365,
-0.029859505593776703,
-0.015943938866257668,
-0.0008387667476199567,
-0.02077900804579258,
-0.04169953241944313,
-0.00007559403456980363,
0.026274478062987328,
-0.007706630043685436,
-0.01191667839884758,
0.0016274137888103724,
0.023762600496411324,
-0.003063193755224347,
0.00599076971411705,
0.02655750699341297,
-0.031652018427848816,
-0.002205263590440154,
-0.01867987960577011,
0.007948383688926697,
0.01273628231137991,
0.0012736282078549266,
0.00434271851554513,
0.0044134752824902534,
0.027029220014810562,
-0.025307463482022285,
0.03443513438105583,
0.014587759971618652,
0.007211329881101847,
-0.003694111481308937,
-0.022819172590970993,
0.029623648151755333,
0.00009765956929186359,
0.010065200738608837,
0.023632878437638283,
0.023786185309290886,
0.0020608012564480305,
-0.01120910793542862,
0.018738845363259315,
-0.01274807471781969,
-0.011091179214417934,
-0.005073875188827515,
0.004649332724511623,
-0.02113279327750206,
-0.015165610238909721,
0.016038281843066216,
0.009522729553282261,
-0.01642744615674019,
-0.009257390163838863,
0.0021286101546138525,
-0.022854549810290337,
0.006155869457870722,
-0.0006876707775518298,
-0.038208846002817154,
0.02606220729649067,
0.006309176795184612,
-0.026156550273299217,
-0.05014321580529213,
-0.0024912403896450996,
0.008773882873356342,
-0.0026357027236372232,
0.015896767377853394,
-0.00021171857952140272,
0.004546144977211952,
0.030614247545599937,
-0.009133565239608288,
-0.0025605233386158943,
0.041274987161159515,
0.014021703042089939,
0.02676977775990963,
0.009204322472214699,
0.011922575533390045,
0.024340450763702393,
-0.029859505593776703,
-0.0207672156393528,
-0.028562292456626892,
0.01595573127269745,
0.019411036744713783,
-0.03910510241985321,
0.017748244106769562,
0.047265756875276566,
-0.017323702573776245,
0.027783963829278946,
-0.0021020760759711266,
0.006892922800034285,
0.023208336904644966,
0.011509825475513935,
-0.005852203816175461,
0.007293879985809326,
-0.0207672156393528,
-0.02712356299161911,
0.009121771901845932,
0.023538535460829735,
0.009151254780590534,
0.03379831835627556,
0.02326730079948902,
0.026015035808086395,
-0.037737131118774414,
-0.003534907940775156,
0.034222859889268875,
0.04226558655500412,
-0.016415651887655258,
0.0028789304196834564,
-0.0026828742120414972,
-0.016592545434832573,
-0.03219449147582054,
-0.0038798488676548004,
0.017925137653946877,
-0.05070926994085312,
0.01865629479289055,
0.026274478062987328,
0.007376430090516806,
0.026722606271505356,
0.0018146253423765302,
0.005976028740406036,
0.002015103818848729,
-0.03066141903400421,
-0.01913980208337307,
-0.019552551209926605,
-0.004888137802481651,
0.018727051094174385,
-0.010878907516598701,
-0.01901008002460003,
0.016109038144350052,
-0.026486748829483986,
0.022713037207722664,
0.011368311010301113,
-0.00543355755507946,
0.020366258919239044,
-0.030236877501010895,
-0.021427614614367485,
-0.005047341343015432,
-0.0263216495513916,
0.013656124472618103,
0.006833958905190229,
-0.017642108723521233,
-0.02490650676190853,
0.001801358419470489,
-0.005468935705721378,
-0.00018260497017763555,
-0.0373125895857811,
-0.02264227904379368,
0.00032135526998899877,
-0.011657236143946648,
0.022571522742509842,
0.028585877269506454,
0.00041827777749858797,
0.03344453498721123,
-0.04719500243663788,
0.001433568773791194,
-0.018243543803691864,
0.027783963829278946,
-0.017076052725315094,
-0.04427037388086319,
0.0027403642889112234,
0.02653392031788826,
-0.0030248670373111963,
-0.02983592078089714,
-0.03514270484447479,
0.007712526246905327,
-0.024694235995411873,
0.016934538260102272,
0.014481624588370323,
0.005740171764045954,
0.011450860649347305,
0.009334043599665165,
-0.060898296535015106,
0.00552200386300683,
-0.002921679522842169,
0.011610064655542374,
0.03802016004920006,
0.05297349765896797,
0.00862057600170374,
-0.019811993464827538,
-0.007400015834718943,
0.04415244609117508,
-0.0016141468659043312,
0.009381215088069439,
0.014045288786292076,
0.02021295204758644,
-0.005000169854611158,
-0.008148862048983574,
-0.005551485810428858,
-0.002822914393618703,
-0.008838743902742863,
-0.009286872111260891,
-0.05410561338067055,
-0.008066312409937382,
-0.03684087470173836,
0.016226965934038162,
0.02676977775990963,
0.029741577804088593,
-0.006238419562578201,
0.01867987960577011,
-0.045260973274707794,
0.03030763380229473,
-0.014021703042089939,
-0.030260462313890457,
-0.01038950402289629,
-0.011279864236712456,
-0.041392914950847626,
0.0009198425686918199,
-0.000993547961115837,
0.02033087983727455,
0.007500255014747381,
0.020932314917445183,
-0.004557937849313021,
-0.02300785854458809,
-0.01714680902659893,
-0.007582805119454861,
0.009416594170033932,
-0.02197008579969406,
-0.001217612181790173,
0.013172617182135582,
-0.016462823376059532,
0.004047897178679705,
0.028585877269506454,
0.00910408329218626,
-0.029670819640159607,
0.020495979115366936,
-0.030378391966223717,
-0.017170395702123642,
-0.007641769014298916,
0.007559219375252724,
0.10028643161058426,
-0.034576646983623505,
-0.004584471695125103,
0.0020136297680437565,
-0.03276054933667183,
-0.02679336443543434,
0.013703295961022377,
0.031156718730926514,
0.008367029950022697,
-0.011415482498705387,
0.04073251783847809,
0.02139223739504814,
0.037123903632164,
0.048445042222738266,
0.026604678481817245,
-0.0054306089878082275,
0.015259952284395695,
0.023998457938432693,
-0.005377541296184063,
-0.029317034408450127,
0.002638651058077812,
0.025425393134355545,
-0.005740171764045954,
0.0014984294539317489,
-0.015389674343168736,
0.002395423362031579,
0.004560885950922966,
-0.02573200687766075,
-0.028114162385463715,
-0.014175009913742542,
0.015059473924338818,
0.0029835919849574566,
0.00649196607992053,
-0.026109378784894943,
0.014646724797785282,
-0.021757815033197403,
-0.0056428806856274605,
-0.01925772987306118,
-0.02030729502439499,
0.023691842332482338,
-0.015059473924338818,
0.012288153171539307,
-0.006527344696223736,
0.028798148036003113,
0.029175519943237305,
0.013019310310482979,
-0.01950537972152233,
0.007612287066876888,
0.0048026395961642265,
-0.033515289425849915,
0.008632369339466095,
-0.008372926153242588,
0.007971969433128834,
-0.0012507796054705977,
-0.02088514342904091,
-0.04214765876531601,
0.021521957591176033,
-0.024930093437433243,
-0.003260724013671279,
-0.03660501912236214,
-0.031534090638160706,
0.02679336443543434,
0.012005125172436237,
-0.0025192482862621546,
0.0028656634967774153
] | 2024-07-03 | 124 | 38957786 | [
"pediatric solid tumors",
"solid tumors",
"solid tumor sites",
"CAR T cell therapy",
"Wilms tumor",
"T cell expansion",
"advanced CAR T cell design",
"intrinsic tumor resistance",
"many rare tumors",
"Immune therapies",
"pediatric patients",
"active pediatric clinical trials",
"combination therapies",
"intensive therapies",
"relapsed or refractory solid tumors",
"preclinical development strategies",
"conventional treatment options",
"B7-H3-CAR T cells",
"novel treatments",
"the hostile tumor microenvironment",
"poor outcomes",
"Ewing sarcoma",
"antitumor activity",
"strategies",
"challenges",
"B7-H3",
"normal tissues",
"sites",
"malignancies",
"B7-H3-CAR"
] | [
"B7-H3",
"CAR T cell therapy",
"Chimeric antigen receptor",
"Immunotherapy",
"Pediatric cancer",
"Solid tumor"
] | 0 | 10.1016/j.ejcped.2024.100160 | [
"Epperly",
"Gottschalk",
"DeRenzo"
] | [
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.",
"Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA."
] | [
"38957786",
"24488779",
"30255612",
"37444389",
"36612267",
"29385370",
"28408462",
"35446934",
"35780062",
"31650176",
"36983330",
"32979309",
"33239386",
"32669548",
"25800760",
"17299405",
"37018492",
"37213274",
"11358824",
"35855615",
"32728609",
"12055244",
"14764704",
"23583036",
"18650384",
"20141543",
"19544488",
"34531301",
"31308249",
"38250867",
"24013874",
"11224528",
"22999863",
"34265738",
"21597388",
"25370943",
"31731055",
"15314238",
"30655315",
"30753824",
"22615450",
"33619171",
"0",
"19890606",
"34739560",
"37775116",
"37110590",
"37097811",
"32929362",
"32967924",
"36320072",
"35405743",
"34211478",
"37062034",
"32958548",
"36768928",
"34552155",
"36327699",
"18613926",
"32580265",
"28866709",
"33795387",
"33320196",
"31887631",
"32547742",
"33767145",
"31466914",
"27208063",
"37149721",
"35333400",
"20598810",
"17686830",
"33653946",
"20495537",
"25609202",
"33514401",
"35101032",
"19844235",
"34052626",
"33708423",
"36941687",
"33531429",
"33348781",
"32298986",
"36259971",
"24216048",
"36159778",
"37739951",
"31110702",
"33051306",
"28399408",
"35303871",
"37282786",
"32002297",
"37597651",
"38036617",
"35443752",
"37422126",
"36890224",
"36732477",
"32341579",
"31485480",
"36599192",
"37676217",
"36059640",
"36056553",
"33543339",
"33811153",
"36635683",
"37714830",
"37483496",
"37574043",
"26830879",
"33479234",
"36396552",
"35852863",
"32685008",
"36032401",
"30889382",
"32707982",
"37770968",
"33925968",
"32848731",
"36381305"
] | [] | 10.107495 | 6.563578 |
38957468 | 780 | Editorial: Cancer immunotherapies for hematologic malignancies - NK/CIK/CAR-T perspective. | null | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-03 | 4 | 38957468 | [] | [
"CAR-T cells",
"CIK cells",
"NK cells",
"cancer",
"cancer immunotherapies"
] | 0 | 10.3389/fimmu.2024.1434259
10.1186/s13046-021-02184-2
10.1186/s40164-024-00481-y
10.1111/ejh.14074 | [
"Sharma",
"Rosato",
"Schmidt-Wolf"
] | [
"Department of Integrated Oncology, Center for Integrated Oncology (CIO), University Hospital of Bonn, Bonn, Germany.\nDepartment of Stereotactic and Functional Neurosurgery, University Hospital of Bonn, Bonn, Germany.",
"Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy.",
"Department of Integrated Oncology, Center for Integrated Oncology (CIO), University Hospital of Bonn, Bonn, Germany."
] | [
"38957468",
"34886895",
"38396050",
"37545132"
] | [] | 33.051861 | 7.437286 |
38955579 | 781 | CAR T Cells in T Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma. | Chimeric antigen receptor (CAR T) therapy produced excellent activity in patients with relapsed/refractory B-lineage malignancies. However, extending these therapies to T cell cancers requires overcoming unique challenges. In the recent years, multiple approaches have been developed in preclinical models and some were tested in clinical trials in patients with treatment-refractory T-cell malignanices with promising early results. Here, we review main hurdles impeding the success of CAR T therapy in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL), discuss potential solutions, and summarize recent progress in both preclinical and clinical development of CAR T therapy for these diseases. | [
0.013257640413939953,
0.02194557897746563,
0.07862089574337006,
0.042415641248226166,
-0.029774634167551994,
-0.024026721715927124,
0.009365135803818703,
-0.002571145538240671,
-0.01828981749713421,
0.00018426771566737443,
-0.016395870596170425,
-0.012453814037144184,
-0.038936059921979904,
0.01024053618311882,
0.01841094344854355,
-0.03911224380135536,
0.05769936740398407,
-0.019170723855495453,
0.03378275781869888,
0.04256980121135712,
0.02673550881445408,
0.008930188603699207,
0.01090121641755104,
0.005891061387956142,
-0.046159494668245316,
-0.021273888647556305,
0.01952308788895607,
0.006744439247995615,
-0.030501382425427437,
-0.012497859075665474,
0.021659284830093384,
-0.014050456695258617,
-0.03261555731296539,
0.012707074172794819,
0.009199965745210648,
0.04946289211511612,
0.023916607722640038,
0.005847015883773565,
-0.004448577295988798,
-0.008390633389353752,
0.034421417862176895,
0.02981868013739586,
0.036007046699523926,
0.07879707217216492,
-0.05862431973218918,
0.0030308684799820185,
-0.004302677232772112,
-0.041336532682180405,
-0.001183029729872942,
-0.015085521154105663,
-0.004107225686311722,
0.016450926661491394,
-0.006480167619884014,
0.014413830824196339,
-0.06276457756757736,
0.04712849110364914,
-0.024533241987228394,
0.007581300567835569,
-0.013092471286654472,
-0.0015402097487822175,
0.0010983800748363137,
-0.00047004612861201167,
-0.0014073855709284544,
-0.037086158990859985,
-0.04963907226920128,
0.010025815106928349,
-0.051092568784952164,
-0.03014902025461197,
-0.005659823305904865,
0.033518485724925995,
-0.01082413736730814,
-0.02185748890042305,
0.01194729283452034,
-0.0037603690288960934,
0.0341351218521595,
-0.0041787996888160706,
0.024357061833143234,
0.027021802961826324,
0.018399931490421295,
-0.011341669596731663,
0.023608289659023285,
0.0010185480350628495,
0.025832578539848328,
-0.052105613052845,
0.011859201826155186,
0.01016345713287592,
-0.002780360635370016,
-0.000995837152004242,
-0.004484363831579685,
-0.02922406792640686,
-0.00521661713719368,
0.010840654373168945,
-0.051092568784952164,
0.05937308818101883,
0.017893411219120026,
0.018124649301171303,
-0.004652286879718304,
-0.05655418708920479,
0.03635941073298454,
0.05721486732363701,
0.055585190653800964,
0.029928794130682945,
-0.021703330799937248,
-0.016516994684934616,
0.03481782227754593,
0.018873419612646103,
-0.06034208461642265,
-0.02638314478099346,
0.015118555165827274,
-0.008528274483978748,
0.0347297340631485,
-0.028519343584775925,
0.0020604950841516256,
0.02970856800675392,
-0.030193066224455833,
-0.05285438150167465,
-0.027175961062312126,
-0.0008650775998830795,
0.014545965939760208,
0.0260528065264225,
-0.011969314888119698,
0.05236988514661789,
0.031162062659859657,
-0.04177698493003845,
-0.02164827473461628,
-0.018377909436821938,
0.09029290080070496,
-0.03164656087756157,
-0.028122935444116592,
-0.03629334270954132,
0.026625394821166992,
0.014281694777309895,
0.014766192995011806,
-0.002319261198863387,
-0.07302713394165039,
0.0002446579746901989,
-0.03274769335985184,
-0.004773411434143782,
-0.02739618718624115,
-0.02988474816083908,
-0.0009153167484328151,
0.001348887919448316,
-0.023850539699196815,
0.004377003293484449,
-0.026008760556578636,
-0.042239461094141006,
0.019534097984433174,
-0.00982210598886013,
0.013576969504356384,
0.016340812668204308,
-0.03589693456888199,
0.04712849110364914,
0.04576308652758598,
0.005458866711705923,
0.018344875425100327,
-0.05836004763841629,
-0.0034107593819499016,
0.06686079502105713,
-0.024268969893455505,
-0.036271318793296814,
-0.002411481225863099,
0.01494237408041954,
-0.03574277460575104,
-0.0012835081433877349,
0.029532385990023613,
-0.03056745044887066,
-0.007030733861029148,
0.01985342800617218,
-0.04360486567020416,
-0.015470918267965317,
-0.03589693456888199,
-0.041248440742492676,
-0.06188367307186127,
-0.03453152999281883,
-0.03047936037182808,
-0.01024053618311882,
0.027770573273301125,
0.031668584793806076,
-0.036843907088041306,
-0.05571732670068741,
0.022529181092977524,
0.03964078798890114,
0.03737245127558708,
-0.022143783047795296,
-0.028607433661818504,
0.03014902025461197,
-0.00986615102738142,
0.013004380278289318,
-0.05021166428923607,
-0.012971346266567707,
0.0009841375285759568,
0.016627106815576553,
0.04338463768362999,
0.01820172742009163,
0.01341179944574833,
0.015393838286399841,
0.04279002547264099,
0.021956590935587883,
-0.04664399102330208,
-0.026999780908226967,
0.02347615547478199,
-0.018344875425100327,
-0.03838549554347992,
-0.0038814935833215714,
-0.011451782658696175,
-0.007840066216886044,
-0.015085521154105663,
0.02164827473461628,
-0.024423127993941307,
-0.029422271996736526,
0.028211025521159172,
0.00024173309793695807,
-0.02748427912592888,
0.026779552921652794,
-0.02970856800675392,
-0.012343700043857098,
0.01452394388616085,
0.039090219885110855,
-0.0006025261827744544,
0.03695402294397354,
-0.006546235643327236,
-0.0011376079637557268,
-0.029290135949850082,
0.013257640413939953,
-0.015217657200992107,
0.010780091397464275,
0.0033474441152065992,
-0.0329458974301815,
0.002213277155533433,
-0.009695475921034813,
-0.0028023833874613047,
-0.0030446327291429043,
0.022617271170020103,
-0.018730271607637405,
0.004154024180024862,
-0.006645337212830782,
0.03616120666265488,
0.005907578393816948,
0.05347101762890816,
-0.025282012298703194,
0.011672009713947773,
0.019721291959285736,
0.02563437446951866,
-0.021747376769781113,
-0.0035373896826058626,
-0.02988474816083908,
-0.021571194753050804,
-0.06038613244891167,
0.032263197004795074,
-0.01661609672009945,
0.004613746888935566,
0.02915799990296364,
-0.01377517357468605,
0.008908165618777275,
0.03314410150051117,
0.028695525601506233,
0.047833215445280075,
-0.040103260427713394,
-0.003933797590434551,
-0.02889372780919075,
-0.01164998672902584,
0.011462793685495853,
-0.04129248484969139,
-0.04116034880280495,
-0.04116034880280495,
0.012960335239768028,
-0.00394480861723423,
0.025105832144618034,
0.043494753539562225,
-0.010939755477011204,
0.02614089660346508,
0.025766510516405106,
0.04364890977740288,
-0.054836422204971313,
-0.04294418543577194,
-0.02565639838576317,
0.02805686742067337,
0.027946755290031433,
0.01527271419763565,
0.04228350520133972,
0.0006417540716938674,
0.00826400239020586,
-0.015415861271321774,
0.0014163322048261762,
-0.012387746013700962,
-0.03635941073298454,
0.012002348899841309,
-0.018245773389935493,
-0.007328039966523647,
-0.009965253062546253,
0.010521325282752514,
0.006997699849307537,
-0.0035979519598186016,
-0.03673379495739937,
-0.02523796819150448,
-0.02093253657221794,
-0.004960604012012482,
-0.0038512125611305237,
-0.025083808228373528,
0.03098588064312935,
-0.03431130200624466,
0.006926126312464476,
-0.00026719679590314627,
-0.056245870888233185,
0.04673208296298981,
0.013554946519434452,
0.0009820729028433561,
-0.01091222744435072,
0.03129419684410095,
0.04032348841428757,
0.016693174839019775,
0.012233586981892586,
0.025678420439362526,
0.01131964661180973,
-0.008489735424518585,
-0.010752563364803791,
-0.001792093855328858,
-0.08778231590986252,
0.01969926804304123,
-0.056818459182977676,
-0.027594391256570816,
-0.006777473259717226,
-0.03021508827805519,
0.021064672619104385,
-0.0030281157232820988,
-0.010747057385742664,
0.019181735813617706,
-0.01619766652584076,
0.03946460410952568,
-0.04063180461525917,
-0.003168510040268302,
-0.026339100673794746,
0.0625883936882019,
-0.02455526404082775,
-0.003366714110597968,
-0.017750263214111328,
-0.029356203973293304,
-0.04902243986725807,
0.02063523232936859,
0.042085301131010056,
0.0005970204947516322,
0.032593537122011185,
-0.02143905870616436,
0.08456701040267944,
0.0019283590372651815,
0.0000516586187586654,
0.029025863856077194,
0.014634056948125362,
-0.02122984267771244,
0.029598454013466835,
0.00006426143227145076,
-0.011104925535619259,
0.037834927439689636,
-0.013378765434026718,
-0.01964421197772026,
0.052590109407901764,
-0.06179558113217354,
-0.015041476115584373,
0.004085203167051077,
0.016869356855750084,
-0.0049798740074038506,
0.01199133787304163,
-0.057919591665267944,
0.04576308652758598,
0.05276628956198692,
0.07919348031282425,
-0.017915433272719383,
0.009871657006442547,
-0.027021802961826324,
-0.031162062659859657,
-0.004484363831579685,
-0.02149411477148533,
0.03578682243824005,
-0.009271539747714996,
-0.012652017176151276,
0.028122935444116592,
0.029862726107239723,
0.0005354259046725929,
0.011220544576644897,
0.01064245030283928,
0.005624036770313978,
-0.010113906115293503,
-0.005560721270740032,
-0.03572075441479683,
-0.021119730547070503,
0.03464164212346077,
-0.012707074172794819,
-0.03307803347706795,
-0.057567231357097626,
0.013543935492634773,
-0.002778984373435378,
0.004674309398978949,
0.04389115795493126,
0.02206670492887497,
0.003080419497564435,
0.06505493819713593,
-0.009739520959556103,
0.08901558816432953,
0.03530232235789299,
0.02069028839468956,
0.017552059143781662,
-0.04411138594150543,
-0.024158857762813568,
-0.03790099546313286,
0.016660140827298164,
-0.019919496029615402,
0.018212739378213882,
0.015492940321564674,
0.020194778218865395,
-0.052325837314128876,
-0.015977438539266586,
0.04664399102330208,
0.04298822954297066,
-0.012013360857963562,
0.024577287957072258,
-0.018047569319605827,
-0.049815256148576736,
0.06580370664596558,
-0.03823133558034897,
0.058404091745615005,
0.06104681268334389,
-0.046908263117074966,
0.03779088333249092,
0.008192429319024086,
-0.007366579491645098,
0.012596961110830307,
0.053823377937078476,
0.024775492027401924,
0.001356458174996078,
-0.02356424555182457,
-0.021813442930579185,
0.036931999027729034,
0.019170723855495453,
-0.032923873513936996,
-0.014050456695258617,
0.03470771014690399,
-0.0440232940018177,
0.01664913073182106,
-0.03999314829707146,
0.007878606207668781,
-0.018906453624367714,
0.017552059143781662,
0.010455257259309292,
0.000025291647034464404,
0.032857805490493774,
0.006166344508528709,
-0.019963540136814117,
0.038759879767894745,
-0.0368218868970871,
-0.014810238033533096,
-0.02107568457722664,
-0.024709424003958702,
-0.0014975408557802439,
-0.004935828503221273,
-0.039750900119543076,
-0.0048835244961082935,
0.04122641682624817,
-0.0661560669541359,
0.012255609966814518,
0.024841560050845146,
0.018432965502142906,
-0.019446007907390594,
0.02521594427525997,
-0.028497321531176567,
0.003394242376089096,
0.05201752111315727,
0.035016026347875595,
-0.015162601135671139,
0.029356203973293304,
-0.020998604595661163,
0.03580884262919426,
-0.005467125214636326,
-0.02069028839468956,
0.007559277582913637,
-0.020888492465019226,
0.09179044514894485,
0.027043825015425682,
0.02116377465426922,
0.007162869907915592,
-0.021626250818371773,
-0.020293880254030228,
0.02143905870616436,
-0.030413292348384857,
-0.006893092300742865,
0.03140431270003319,
0.016087552532553673,
-0.018366897478699684,
0.009139403700828552,
-0.050167616456747055,
0.028783615678548813,
0.004495375324040651,
0.011793133802711964,
-0.0009318337542936206,
-0.007636357098817825,
-0.01907162368297577,
-0.03012699820101261,
-0.020315902307629585,
-0.014590011909604073,
-0.005731396842747927,
-0.006050725467503071,
-0.01874128356575966,
0.011209533549845219,
0.002132068620994687,
0.030743632465600967,
0.037834927439689636,
0.03365062177181244,
0.01880735158920288,
0.04695231094956398,
-0.012982357293367386,
0.0033061516005545855,
-0.03779088333249092,
-0.03188880905508995,
0.05276628956198692,
-0.0052221231162548065,
-0.04186507314443588,
-0.015834292396903038,
-0.08381824195384979,
-0.01697947084903717,
0.015977438539266586,
-0.010361661203205585,
-0.022749407216906548,
0.008230968378484249,
0.0010846159420907497,
-0.0016627107979729772,
0.02997283823788166,
-0.01808060333132744,
-0.013389776460826397,
-0.01828981749713421,
-0.02126287668943405,
-0.024577287957072258,
0.033011965453624725,
-0.001885690144263208,
-0.014590011909604073,
0.009469743818044662,
-0.0011272848350927234,
-0.018432965502142906,
-0.05355910584330559,
0.05734700337052345,
-0.025876624509692192,
-0.06690483540296555,
0.013885286636650562,
0.008434678427875042,
0.021791420876979828,
0.008875131607055664,
0.008798052556812763,
0.003677783999592066,
0.0035676707047969103,
-0.02323390543460846,
0.01240976806730032,
-0.011220544576644897,
0.02473144605755806,
-0.020954560488462448,
-0.012057405896484852,
-0.01423764880746603,
0.035610638558864594,
-0.03763672336935997,
-0.020822424441576004,
-0.026911688968539238,
-0.007383096497505903,
-0.017474979162216187,
-0.02243007905781269,
-0.018763305619359016,
0.010273570194840431,
-0.026427190750837326,
-0.006292975042015314,
0.03065554052591324,
-0.004844984970986843,
-0.02481953613460064,
-0.03763672336935997,
0.01668216474354267,
-0.0024032227229326963,
-0.001317230286076665,
-0.00016723456792533398,
-0.01456798892468214,
0.04659994691610336,
0.007063767872750759,
0.007928157225251198,
0.01820172742009163,
-0.015217657200992107,
0.025370102375745773,
-0.020205790176987648,
-0.03845156356692314,
-0.0350380502641201,
0.030787676572799683,
-0.011308635585010052,
0.02371840365231037,
-0.04519049823284149,
-0.007537255063652992,
-0.0013757279375568032,
0.00464953389018774,
0.03966280817985535,
0.008946705609560013,
0.020172756165266037,
0.020216800272464752,
-0.052986517548561096,
0.013290674425661564,
-0.00709680188447237,
-0.009398169815540314,
-0.029356203973293304,
-0.010372672230005264,
0.000390902190702036,
-0.009899185039103031,
0.010400201193988323,
-0.026074828580021858,
-0.038605719804763794,
0.025942692533135414,
-0.007625345606356859,
0.0009166931849904358,
0.0055524627678096294,
-0.006441627629101276,
0.05395551398396492,
0.026911688968539238,
-0.017827343195676804,
-0.013687082566320896,
0.039002127945423126,
0.02389458566904068,
-0.02006264217197895,
-0.006926126312464476,
0.023916607722640038,
-0.013841241598129272,
-0.015129567123949528,
-0.00242111599072814,
-0.02371840365231037,
-0.007702425122261047,
0.0036199744790792465,
-0.048670075833797455,
-0.030941836535930634,
-0.00014271715190261602,
0.016208676621317863,
0.009062324650585651,
-0.007085790392011404,
-0.043406661599874496,
-0.0041154841892421246,
0.02521594427525997,
0.012894267216324806,
-0.024202901870012283,
0.03153644874691963,
-0.014083490706980228,
-0.0005034242058172822,
0.008803557604551315,
0.0034768274053931236,
0.0009435333195142448,
-0.01489832904189825,
-0.025524262338876724,
-0.004313688259571791,
-0.025039764121174812,
-0.020370960235595703,
0.006425110623240471,
-0.010185480117797852,
0.0030281157232820988,
0.017331833019852638,
-0.01194729283452034,
0.03587491065263748,
-0.02581055648624897,
0.009541316889226437,
-0.005136785097420216,
-0.0008024506387300789,
0.001757683465257287,
0.07003205269575119,
0.07584603875875473,
-0.019963540136814117,
0.036271318793296814,
-0.00964041892439127,
-0.007840066216886044,
-0.015581031329929829,
-0.023542221635580063,
0.011005823500454426,
-0.035346366465091705,
0.017552059143781662,
-0.0003675031184684485,
0.067081019282341,
0.02638314478099346,
-0.0030281157232820988,
-0.013654048554599285,
-0.03569873049855232,
0.02227591909468174,
0.018917463719844818,
-0.02314581535756588,
-0.016847334802150726,
0.010075366124510765,
-0.030369246378540993,
0.0023440367076545954,
-0.037680771201848984,
-0.049242664128541946,
-0.019357917830348015,
-0.005065211560577154,
0.030259134247899055,
-0.004712848924100399,
0.006408593617379665,
-0.010157951153814793,
-0.0028656984213739634,
-0.006771967746317387,
-0.026515280827879906,
-0.007410624995827675,
0.0413145087659359,
0.024268969893455505,
0.012013360857963562,
-0.018730271607637405,
-0.0017260259483009577,
-0.006959160324186087,
0.021923556923866272,
0.009392663836479187,
0.044661954045295715,
-0.03569873049855232,
0.008825580589473248,
-0.009062324650585651,
0.016483960673213005,
-0.004016382619738579,
0.006149827502667904,
0.025436170399188995,
-0.0036337387282401323,
-0.005453360732644796,
-0.029003841802477837,
-0.013896297663450241,
-0.001584255020134151,
0.01598845049738884,
-0.00033016782253980637,
0.06254435330629349,
-0.00550841772928834,
0.016957446932792664,
0.00020732269331347197,
0.03362860158085823,
-0.013576969504356384,
0.0008561308495700359,
0.018454987555742264,
0.022683339193463326,
-0.02814495749771595,
0.05228179320693016,
-0.013543935492634773,
-0.021637262776494026,
-0.011462793685495853,
0.008049282245337963,
-0.04470599815249443,
-0.00982210598886013,
-0.026515280827879906,
0.03314410150051117,
-0.011594929732382298,
-0.016010472550988197,
-0.0066728657111525536,
-0.00541206868365407,
0.020337926223874092,
-0.04179900512099266,
-0.05369124189019203,
0.02539212629199028,
-0.002092152601107955,
0.011782122775912285,
0.03398096188902855,
0.010879193432629108,
0.004897288978099823,
-0.030435314401984215,
0.004319194238632917,
0.006320503074675798,
-0.011517850682139397,
-0.03087576851248741,
0.00884760357439518,
-0.032439377158880234,
0.0024885605089366436,
-0.006127804983407259,
-0.031272176653146744,
-0.03321016952395439,
-0.02093253657221794,
0.01706756092607975,
-0.02218782901763916,
-0.018300829455256462,
-0.007751976139843464,
0.015393838286399841,
0.024841560050845146,
0.011308635585010052,
0.02556830644607544,
-0.0006706587737426162,
-0.036601658910512924,
-0.019666234031319618,
0.012982357293367386,
-0.03257151320576668,
-0.007118824403733015,
0.022386033087968826,
-0.007443658541887999,
0.0317346528172493,
0.008720972575247288,
0.015735190361738205,
-0.005194594617933035,
0.009359629824757576,
-0.025942692533135414,
0.017827343195676804,
-0.00517257209867239,
0.0030556439887732267,
-0.013929331675171852,
0.03497198224067688,
-0.04060978442430496,
0.001424590707756579,
-0.036337386816740036,
0.01635182462632656,
-0.035104118287563324,
-0.004668803885579109,
0.004878018982708454,
0.018576113507151604,
0.032593537122011185,
-0.0739520862698555,
-0.007339050993323326,
-0.008869625627994537,
0.016241710633039474,
-0.01892847567796707,
0.013687082566320896,
-0.048758167773485184,
-0.009183448739349842,
0.005533193238079548,
-0.0007597817457281053,
0.011793133802711964,
-0.026537304744124413,
0.014061467722058296,
0.017629139125347137,
-0.014832261018455029,
-0.01776127517223358,
0.0004893159493803978,
-0.06681674718856812,
-0.015349793247878551,
0.016990480944514275,
0.017177674919366837,
0.0017370372079312801,
-0.015019453130662441,
0.049991436302661896,
-0.003738346276804805,
-0.009816600009799004,
-0.0018086108611896634,
-0.028541365638375282,
-0.05571732670068741,
-0.0007095425389707088,
0.03439939394593239,
0.013885286636650562,
-0.026955734938383102,
0.02473144605755806,
0.00211142236366868,
-0.026581348851323128,
0.02189052291214466,
-0.020437028259038925,
-0.006342525593936443,
0.0000019355852600710932,
-0.018642181530594826,
0.012674040161073208,
0.035170186311006546,
0.012607972137629986,
-0.004489869810640812,
-0.004831220954656601,
-0.03779088333249092,
-0.00818692333996296,
0.036601658910512924,
-0.02997283823788166,
0.02182445488870144,
-0.012057405896484852,
-0.01423764880746603,
0.004126495681703091,
0.00014667435607407242,
-0.007575794588774443,
-0.005764430854469538,
0.03274769335985184,
0.016803288832306862,
0.0012656146427616477,
-0.024687400087714195,
0.06452639400959015,
0.01957814395427704,
-0.014171580784022808,
-0.0033969951327890158,
-0.025590330362319946,
-0.046423766762018204,
0.038011111319065094,
-0.05417574197053909,
0.023211883381009102,
-0.014975408092141151,
0.0007253713556565344,
-0.03208701312541962,
0.029510363936424255,
0.017618127167224884,
0.030281156301498413,
0.0005997733678668737,
-0.007548266556113958,
0.006937137804925442,
0.01486529503017664,
-0.01703452691435814,
0.010003793053328991,
-0.00893569365143776,
0.007394107989966869,
-0.026625394821166992,
-0.020998604595661163,
-0.011760099790990353,
0.02464335598051548,
0.020668266341090202,
-0.0023096264339983463,
-0.021185798570513725,
0.007250960450619459,
-0.005056953057646751,
0.0011121443239971995,
-0.016153620555996895,
-0.004258631728589535,
-0.019082633778452873,
-0.004198069218546152,
-0.01419360376894474,
-0.007702425122261047,
0.04276800528168678,
-0.04083000868558884,
-0.0007680402486585081,
-0.02206670492887497,
-0.005241392645984888,
-0.026184942573308945,
0.048009395599365234,
-0.003394242376089096,
-0.00690960930660367,
-0.01976533606648445,
0.023432109504938126,
-0.01030109915882349,
0.044573862105607986,
-0.007394107989966869,
0.012629995122551918,
0.004525656346231699,
0.012971346266567707,
-0.011760099790990353,
0.020877480506896973,
0.01781633123755455,
0.06501089036464691,
0.021152764558792114,
0.006584775168448687,
-0.01626373454928398,
-0.007195903919637203,
0.0026785058435052633,
0.04290014132857323,
0.0053432476706802845,
0.010097389109432697,
0.01769520714879036,
0.04510240629315376,
0.01104986947029829,
-0.006513201631605625,
-0.012013360857963562,
0.01757408119738102,
0.03565468639135361,
0.003955820109695196,
0.023872561752796173,
0.017408911138772964,
0.02314581535756588,
-0.014700124971568584,
0.001870549633167684,
-0.0046302638947963715,
-0.001837515621446073,
0.05937308818101883,
-0.014744170010089874,
-0.050079528242349625,
0.02413683384656906,
-0.018256783485412598,
0.017563071101903915,
-0.012685051187872887,
0.036271318793296814,
0.02257322520017624,
0.06637629121541977,
-0.0038787408266216516,
0.01679227687418461,
0.011407737620174885,
-0.0017508013406768441,
-0.0305454283952713,
0.024092789739370346,
-0.030104974284768105,
0.045014314353466034,
-0.02431301586329937,
-0.01940196193754673,
-0.0011850943556055427,
-0.008225463330745697,
-0.015911370515823364,
0.005858027376234531,
0.03679986298084259,
0.02236401103436947,
0.011848190799355507,
-0.03999314829707146,
0.04135855287313461,
-0.01703452691435814,
-0.013356742449104786,
0.011005823500454426,
0.020536130294203758,
0.024379083886742592,
0.005414821207523346,
0.032439377158880234,
-0.02715393900871277,
0.01670418679714203,
-0.0003688795259222388,
0.03171262890100479,
0.004982626531273127,
-0.02713191509246826,
-0.009062324650585651,
-0.01668216474354267,
0.015669122338294983,
0.0015126813668757677,
-0.009244010783731937,
-0.0386277437210083,
0.013709105551242828,
0.032505445182323456,
0.03180072084069252,
-0.010069861076772213,
-0.016274744644761086,
0.014997431077063084,
-0.02446717396378517,
-0.05012357234954834,
-0.06034208461642265,
0.021571194753050804,
0.05800768360495567,
-0.012288643978536129,
-0.04120439663529396,
0.015503952279686928,
0.021670296788215637,
-0.045080382376909256,
-0.003220813814550638,
0.04345070570707321,
0.0000188289432117017,
0.03420118987560272,
-0.02631707675755024,
0.020315902307629585,
0.0016049012774601579,
0.002948283450677991,
0.01519563514739275,
-0.002019202569499612,
-0.02548021636903286,
-0.013687082566320896,
-0.042261481285095215,
-0.047084443271160126,
0.004159529693424702,
-0.016175642609596252,
0.011583918705582619,
0.0011706419754773378,
0.051004476845264435,
0.010290087200701237,
0.010785597376525402,
0.003994359634816647,
0.0013949978165328503,
0.006854552775621414,
0.011038857512176037,
0.018796339631080627,
-0.008451195433735847,
0.0020095675718039274,
-0.015294737182557583,
-0.015911370515823364,
-0.011594929732382298,
0.005676340311765671,
0.07355567812919617,
0.018256783485412598,
0.018576113507151604,
-0.02715393900871277,
-0.017915433272719383,
0.01131964661180973,
0.06020994856953621,
-0.0329458974301815,
0.0012614853912964463,
-0.01336775440722704,
-0.00809883326292038,
0.02180243283510208,
0.019875450059771538,
0.03616120666265488,
0.049154575914144516,
0.012530893087387085,
0.006491178646683693,
0.016307778656482697,
0.02915799990296364,
0.00211142236366868,
0.002787242876365781,
0.014391807839274406,
0.012530893087387085,
-0.010813125409185886,
0.01764014922082424,
0.009981770068407059,
-0.013907309621572495,
-0.029003841802477837,
0.0066067976877093315,
0.013676071539521217,
0.014270682819187641,
0.01452394388616085,
-0.0013963741948828101,
0.005186336115002632,
-0.013081459328532219,
-0.018554089590907097,
0.025259990245103836,
-0.012530893087387085,
-0.022286931052803993,
0.0030033402144908905,
-0.011583918705582619,
0.007685908116400242,
-0.02407076582312584,
0.0036998067516833544,
0.037504587322473526,
0.01793745532631874,
-0.008528274483978748,
0.003430029144510627,
-0.004253126215189695,
-0.02565639838576317,
-0.018003523349761963,
0.01706756092607975,
-0.011253578588366508,
-0.0050679645501077175,
-0.002487184014171362,
-0.034443438053131104,
0.007085790392011404,
-0.006320503074675798,
-0.009877162985503674,
-0.018168693408370018,
0.01203538291156292,
0.025700442492961884,
-0.015008442103862762,
-0.017133628949522972,
0.011071891523897648,
0.0024348802398890257,
-0.03939853608608246,
-0.02263929322361946,
0.037108179181814194,
-0.010928744450211525,
-0.052413929253816605,
0.025590330362319946,
0.02748427912592888,
-0.01519563514739275,
0.019930506125092506,
0.015834292396903038,
-0.018135659396648407,
0.0011541249696165323,
0.011231556534767151,
-0.00111696170642972,
-0.018917463719844818,
0.0001628472382435575,
-0.01865319162607193,
-0.026361122727394104,
-0.031998924911022186,
0.019985562190413475,
0.015702156350016594,
0.0002653042320162058,
-0.019787359982728958,
-0.04459588602185249,
0.013477867469191551,
-0.006645337212830782,
0.0008561308495700359,
-0.003914527595043182,
-0.010835148394107819,
0.002926260931417346,
0.00630949204787612,
-0.006215895526111126,
0.005073470063507557,
-0.005453360732644796,
0.01169403176754713,
0.002451397245749831,
0.0068820808082818985,
0.011969314888119698,
0.014050456695258617,
0.005670834798365831,
0.0008671422256156802,
-0.030611496418714523,
-0.024180879816412926,
-0.006766462232917547,
0.059152863919734955,
-0.02105366252362728,
-0.04327452555298805,
0.047260627150535583,
-0.00020921525720041245,
-0.009150414727628231,
-0.0011176499538123608,
-0.013874275609850883,
0.0008533780346624553,
-0.013543935492634773,
0.0017205202020704746,
0.037262339144945145,
0.025612352415919304,
-0.020525118336081505,
0.0011905999854207039,
0.02772652730345726,
-0.005676340311765671,
-0.007983214221894741,
-0.003688795492053032,
0.011011329479515553,
0.01844397746026516,
0.023167837411165237,
-0.024709424003958702,
0.0068160127848386765,
0.00032225344330072403,
0.01307044830173254,
0.05505664646625519,
0.010235031135380268,
-0.00601769145578146,
0.022319965064525604,
-0.010504808276891708,
-0.01527271419763565,
-0.013874275609850883,
-0.013015391305088997,
0.002312379190698266,
-0.01647294871509075,
-0.01943499594926834,
-0.02856338955461979,
-0.004619252867996693,
0.0049798740074038506,
0.002975811716169119,
-0.0033474441152065992,
-0.000272358360234648,
-0.0063865710981190205,
-0.03598502650856972,
-0.01299336925148964,
0.004429307300597429,
0.010427729226648808,
0.001471388852223754,
0.023079747334122658,
-0.05012357234954834,
-0.019875450059771538,
0.008671421557664871,
0.0013007132802158594,
0.002520218025892973,
0.019203757867217064,
-0.006436122115701437,
0.008027259260416031,
0.013918320648372173,
0.013962365686893463,
-0.024599310010671616,
-0.027660459280014038,
-0.06043017655611038,
0.023277951404452324,
-0.017750263214111328,
-0.00003182962609571405,
0.0008210322703234851,
-0.01637384667992592,
-0.07989820837974548,
-0.016087552532553673,
-0.005775442346930504,
0.00489453598856926,
-0.022408055141568184,
0.002879462670534849,
0.002085270592942834,
-0.007542760577052832,
0.013477867469191551,
0.006436122115701437,
-0.02889372780919075,
0.02722000703215599,
0.0059901634231209755,
0.023498177528381348,
0.01274010818451643,
-0.008208946324884892,
-0.032835785299539566,
0.015173612162470818,
-0.012861233204603195,
0.00941468682140112,
-0.024379083886742592,
0.03228521719574928,
0.001870549633167684,
-0.0016324296593666077,
0.05289842560887337,
0.010224019177258015,
0.006557246670126915,
-0.009585361927747726,
-0.03147038072347641,
-0.008665916509926319,
0.021483104676008224,
0.01381921861320734,
0.03765874728560448,
0.01019649114459753,
-0.04239361733198166,
-0.02035994827747345,
-0.0063645485788583755,
-0.028783615678548813,
-0.029422271996736526,
-0.019115667790174484,
0.004715601913630962,
0.014479897916316986,
-0.012486848048865795,
-0.02128490060567856,
-0.009282550774514675,
0.011738077737390995,
0.030743632465600967,
0.006259941030293703,
-0.0275503471493721,
-0.022859519347548485,
-0.007586806081235409,
-0.006667360197752714,
0.018499033525586128,
0.005591002758592367,
0.02514987625181675,
0.015448895283043385,
0.018752293661236763,
-0.016450926661491394,
0.051488976925611496,
0.016539016738533974,
0.008875131607055664,
-0.027704505249857903,
-0.03305600956082344,
0.0014411077136173844,
0.008335576392710209,
-0.0011527485912665725,
0.016748232766985893,
0.011815156787633896,
-0.019115667790174484,
-0.027352143079042435,
0.0338268056511879,
-0.01832285150885582,
-0.001610406907275319,
-0.007416130509227514,
-0.006937137804925442,
0.0052248756401240826,
-0.03087576851248741,
-0.005555215757340193,
0.01113795954734087,
-0.029202045872807503,
-0.004470599815249443,
-0.004935828503221273,
-0.008126361295580864,
0.0001286949118366465,
0.005522181745618582,
-0.041072260588407516,
0.024114811792969704,
0.005764430854469538,
-0.025678420439362526,
-0.061002764850854874,
0.003589693456888199,
-0.003972337115556002,
-0.032351285219192505,
0.0061773560009896755,
-0.01982039399445057,
0.021758386865258217,
0.03479580208659172,
-0.03012699820101261,
-0.007047250866889954,
0.04576308652758598,
0.02002960816025734,
0.006667360197752714,
0.03171262890100479,
0.013940343633294106,
0.020492084324359894,
-0.0049688625149428844,
0.0004229038895573467,
-0.014380796812474728,
-0.004379756283015013,
0.026757530868053436,
-0.009095358662307262,
0.011396725662052631,
0.026074828580021858,
-0.019721291959285736,
0.012431791052222252,
0.003675031242892146,
-0.026691462844610214,
0.03631536662578583,
-0.0003644061798695475,
-0.0051560550928115845,
-0.0033832311164587736,
0.006738933734595776,
-0.03014902025461197,
0.01952308788895607,
0.012310666032135487,
-0.015944404527544975,
0.00488903047516942,
-0.023101769387722015,
0.03479580208659172,
-0.0061112879775464535,
-0.02255120314657688,
0.00742714200168848,
0.061399172991514206,
0.002266957424581051,
0.008588837459683418,
0.004104473162442446,
-0.0290478877723217,
-0.031514424830675125,
-0.008021753281354904,
0.006513201631605625,
-0.034663666039705276,
0.0029372721910476685,
-0.01697947084903717,
-0.008330070413649082,
-0.0028326644096523523,
0.007922651246190071,
0.008913671597838402,
-0.0017631890950724483,
-0.015735190361738205,
-0.0022352999076247215,
-0.03702009096741676,
-0.007168375421315432,
-0.0018788081360980868,
-0.01307044830173254,
-0.013532924465835094,
0.024202901870012283,
-0.019567131996154785,
0.0017274023266509175,
-0.013643037527799606,
0.012233586981892586,
-0.004941334016621113,
-0.013929331675171852,
-0.019919496029615402,
-0.013290674425661564,
-0.012057405896484852,
0.02640516869723797,
-0.0059901634231209755,
-0.014094501733779907,
-0.027418211102485657,
-0.014446863904595375,
0.005935106426477432,
0.009844128973782063,
-0.04149068892002106,
0.019534097984433174,
-0.013378765434026718,
-0.018212739378213882,
0.020536130294203758,
0.04946289211511612,
-0.0028684514109045267,
0.007272982969880104,
-0.03303398936986923,
0.02147209271788597,
-0.014204614795744419,
0.026867644861340523,
-0.015669122338294983,
-0.02288154326379299,
0.002097658347338438,
-0.010086378082633018,
-0.03479580208659172,
-0.04036753252148628,
-0.029268113896250725,
0.006805001758038998,
-0.012751119211316109,
-0.0024679142516106367,
-0.0017067560693249106,
0.002568392548710108,
-0.01928083784878254,
0.029003841802477837,
-0.051092568784952164,
-0.016880368813872337,
-0.01169403176754713,
0.023520199581980705,
0.020789390429854393,
0.044683974236249924,
-0.015801258385181427,
0.00033102810266427696,
-0.02128490060567856,
0.005318472161889076,
-0.045080382376909256,
-0.0005471254116855562,
0.021185798570513725,
-0.0029510362073779106,
-0.02572246640920639,
0.03446546196937561,
0.012299655005335808,
-0.03279174119234085,
-0.004822962451726198,
-0.020139722153544426,
-0.02063523232936859,
0.0055634742602705956,
-0.027264051139354706,
0.006568258162587881,
-0.002948283450677991,
0.03340837359428406,
0.023255927488207817,
0.03763672336935997,
-0.03208701312541962,
0.023608289659023285,
-0.019710280001163483,
-0.015801258385181427,
0.011683020740747452,
0.00011742550850613043,
-0.03012699820101261,
0.018190717324614525,
0.005260662641376257,
0.011716054752469063,
0.02862945757806301,
0.010818631388247013,
-0.011870212852954865,
0.015085521154105663,
-0.02338806353509426,
-0.0027115398552268744,
0.025127854198217392,
0.0024679142516106367,
0.012277632020413876,
0.034685686230659485,
0.024423127993941307,
-0.011088408529758453,
0.019060611724853516,
0.015470918267965317,
-0.027616415172815323,
0.020668266341090202,
-0.03424523398280144,
-0.015184623189270496,
-0.02799079939723015,
0.018454987555742264,
0.0976044237613678,
-0.002487184014171362,
0.0055304402485489845,
0.035610638558864594,
-0.0017631890950724483,
-0.023498177528381348,
0.014997431077063084,
-0.00041395716834813356,
0.050079528242349625,
-0.03688795492053032,
0.009089852683246136,
0.025370102375745773,
0.04256980121135712,
0.009249516762793064,
0.016131598502397537,
-0.006480167619884014,
0.003738346276804805,
0.05338292568922043,
0.0062984805554151535,
0.0021361978724598885,
0.004550431855022907,
0.01489832904189825,
-0.010967284440994263,
0.033760737627744675,
-0.031007904559373856,
0.0014865294797345996,
0.015019453130662441,
0.0001286949118366465,
-0.014325739815831184,
-0.001757683465257287,
0.0011775241000577807,
0.021273888647556305,
0.014127535745501518,
-0.019512075930833817,
-0.017463969066739082,
-0.018421953544020653,
-0.024268969893455505,
-0.014788215979933739,
0.01877431757748127,
-0.010928744450211525,
0.0015085521154105663,
0.008109844289720058,
0.0018402684945613146,
-0.004198069218546152,
0.027506301179528236,
0.0034052536357194185,
-0.009678958915174007,
0.017838353291153908,
-0.0049468399956822395,
-0.023542221635580063,
0.00582499336451292,
-0.027197983115911484,
0.008825580589473248,
-0.0065737636759877205,
-0.028937773779034615,
-0.017078572884202003,
0.003964078612625599,
0.00977806095033884,
0.01931387186050415,
-0.02182445488870144,
-0.02530403435230255,
0.018102625384926796,
0.0061773560009896755,
0.0033254215959459543,
0.008456701412796974
] | 2024-07-03 | 1 | 38955579 | [
"CAR T therapy",
"T cell cancers",
"preclinical models",
"clinical trials",
"recent progress",
"CAR T) therapy",
"potential solutions",
"patients",
"Chimeric antigen receptor",
"excellent activity",
"multiple approaches",
"main hurdles",
"treatment-refractory T-cell malignanices",
"T-cell acute lymphoblastic leukemia/lymphoma",
"unique challenges",
"early results",
"relapsed/refractory B-lineage malignancies",
"T-ALL/LBL",
"both preclinical and clinical development",
"these therapies",
"the recent years",
"the success",
"these diseases",
"some",
"we"
] | [
"Cell therapy",
"Chimeric antigen receptor",
"T-cell ALL",
"T-cell lymphoblastic lymphoma",
"T-cell malignancies"
] | 0 | 10.1016/j.clml.2024.05.018 | [
"Shmidt",
"Mamonkin"
] | [
"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX. Electronic address: [email protected]."
] | [
"38955579"
] | [] | 6.943893 | 6.132626 |
38955421 | 782 | Tethered IL15-IL15Rα augments antitumor activity of CD19 CAR-T cells but displays long-term toxicity in an immunocompetent lymphoma mouse model. | Adoptive cell therapy using genetically modified T cells to express chimeric antigen receptors (CAR-T) has shown encouraging results, particularly in certain blood cancers. Nevertheless, over 40% of B cell malignancy patients experience a relapse after CAR-T therapy, likely due to inadequate persistence of the modified T cells in the body. IL15, known for its pro-survival and proliferative properties, has been suggested for incorporation into the fourth generation of CAR-T cells to enhance their persistence. However, the potential systemic toxicity associated with this cytokine warrants further evaluation.
We analyzed the persistence, antitumor efficacy and potential toxicity of anti-mouse CD19 CAR-T cells which express a membrane-bound IL15-IL15Rα chimeric protein (CD19/mbIL15q CAR-T), in BALB/c mice challenged with A20 tumor cells as well as in NSG mice.
Conventional CD19 CAR-T cells showed low persistence and poor efficacy in BALB/c mice treated with mild lymphodepletion regimens (total body irradiation (TBI) of 1 Gy). CD19/mbIL15q CAR-T exhibits prolonged persistence and enhanced in vivo efficacy, effectively eliminating established A20 B cell lymphoma. However, this CD19/mbIL15q CAR-T displays important long-term toxicities, with marked splenomegaly, weight loss, transaminase elevations, and significant inflammatory findings in some tissues. Mice survival is highly compromised after CD19/mbIL15q CAR-T cell transfer, particularly if a high TBI regimen is applied before CAR-T cell transfer.
Tethered IL15-IL15Rα augments the antitumor activity of CD19 CAR-T cells but displays long-term toxicity in immunocompetent mice. Inducible systems to regulate IL15-IL15Rα expression could be considered to control this toxicity. | [
0.046288907527923584,
0.03665139153599739,
0.0406169518828392,
0.0570560023188591,
-0.030787169933319092,
-0.011319872923195362,
-0.011265796609222889,
-0.007005823310464621,
0.007252168841660023,
-0.019731666892766953,
-0.013963579200208187,
-0.00862208940088749,
-0.05422002822160721,
0.0063989725895226,
0.011776512488722801,
-0.043693266808986664,
0.043356794863939285,
-0.0264851376414299,
0.005254367832094431,
0.044654615223407745,
0.023468907922506332,
0.04340486228466034,
-0.02089730277657509,
0.0084538534283638,
-0.010911299847066402,
-0.015285433270037174,
0.018145443871617317,
-0.0028299682307988405,
-0.017364347353577614,
-0.031412046402692795,
0.04746655747294426,
-0.012677776627242565,
-0.003277595853433013,
-0.028263630345463753,
-0.025163283571600914,
0.04044871777296066,
0.04780302941799164,
0.0035209369380027056,
-0.011590251699090004,
-0.04984589293599129,
0.03520936891436577,
-0.000320511928293854,
0.029441282153129578,
0.06974579393863678,
-0.04886051267385483,
-0.02006813883781433,
-0.004899870604276657,
-0.024826811626553535,
0.04950942099094391,
0.004536360967904329,
-0.00042096528341062367,
0.024189919233322144,
-0.03326264023780823,
0.02363714389503002,
-0.032060954719781876,
0.041241828352212906,
-0.008754274807870388,
0.015898292884230614,
-0.000659424636978656,
-0.021402008831501007,
0.015645937994122505,
-0.025019081309437752,
0.012990214861929417,
-0.04874034225940704,
-0.06811150163412094,
-0.011037476360797882,
-0.06566006690263748,
-0.016943758353590965,
-0.0009883858729153872,
-0.012161051854491234,
-0.018313679844141006,
-0.016054511070251465,
0.0024063740856945515,
0.010550794191658497,
0.0355939082801342,
0.023673193529248238,
0.003731231903657317,
-0.026292867958545685,
0.016715439036488533,
-0.02171444706618786,
-0.01300223171710968,
0.011974791064858437,
-0.0030823219567537308,
-0.02951338328421116,
0.017256196588277817,
0.01577812433242798,
0.006963764317333698,
-0.055469777435064316,
-0.04989396035671234,
0.007444438524544239,
-0.023793362081050873,
0.016547203063964844,
-0.038982659578323364,
0.009829782880842686,
0.009252974763512611,
-0.025475721806287766,
0.015597871504724026,
-0.04818756878376007,
0.031099608168005943,
0.03321457281708717,
0.03504113480448723,
-0.009295033290982246,
-0.012581641785800457,
-0.03415188565850258,
0.019395194947719574,
0.015213332138955593,
-0.042563680559396744,
-0.008249567821621895,
0.0007499265484511852,
-0.0017048906302079558,
0.10574828088283539,
-0.004091737326234579,
-0.010454659350216389,
0.037588708102703094,
-0.02698984555900097,
-0.043837469071149826,
-0.04085728898644447,
-0.018962590023875237,
0.009961968287825584,
0.037588708102703094,
-0.050518836826086044,
0.06046878919005394,
0.037997279316186905,
-0.023060334846377373,
-0.01697980798780918,
-0.05023043230175972,
0.1118047684431076,
-0.028552034869790077,
-0.019887886941432953,
-0.05066303908824921,
0.057344406843185425,
0.01771283708512783,
0.03744450584053993,
-0.009415201842784882,
-0.06628494709730148,
-0.00984179973602295,
-0.004653525073081255,
-0.016354933381080627,
-0.030594900250434875,
-0.01259365864098072,
0.016955774277448654,
-0.018409814685583115,
-0.04381343349814415,
0.023829413577914238,
-0.037108033895492554,
-0.03607458248734474,
0.00044725212501361966,
-0.007450446952134371,
0.03593038022518158,
0.025379586964845657,
0.003178456798195839,
0.05777701362967491,
0.02291613258421421,
0.00436812499538064,
0.010448651388287544,
-0.05224926397204399,
-0.01843384839594364,
0.05561397969722748,
-0.03787711262702942,
-0.08142617344856262,
-0.00517926225438714,
-0.00796116329729557,
-0.038405850529670715,
-0.029537416994571686,
0.01649913564324379,
0.016643337905406952,
0.03818954899907112,
0.04590436816215515,
-0.07094748318195343,
-0.020668981596827507,
-0.006549183279275894,
-0.03143607825040817,
-0.08243559300899506,
-0.061237867921590805,
-0.06431417912244797,
0.023276638239622116,
0.009018645621836185,
-0.026509171351790428,
-0.027494551613926888,
0.008664148859679699,
0.02251957729458809,
0.022038903087377548,
0.01765275187790394,
-0.002561091212555766,
-0.06801536679267883,
0.014852826483547688,
-0.0026572258211672306,
0.022952184081077576,
-0.0288404393941164,
0.020524779334664345,
0.0029170901980251074,
-0.007336286827921867,
0.05426809564232826,
0.014780725352466106,
-0.02431008778512478,
0.002667740685865283,
0.05239346623420715,
0.02259167842566967,
-0.030667001381516457,
-0.04066501930356026,
0.03179658576846123,
0.004551381804049015,
-0.028744304552674294,
-0.0015832199715077877,
-0.019935954362154007,
0.020933352410793304,
-0.006825570948421955,
0.03756467252969742,
-0.03227725997567177,
-0.016607286408543587,
0.06436225026845932,
0.019479313865303993,
0.00026230531511828303,
-0.008555997163057327,
-0.02747051790356636,
-0.013302653096616268,
-0.032469529658555984,
0.03600248321890831,
0.029152877628803253,
0.03794921189546585,
0.003731231903657317,
-0.014768708497285843,
0.00796116329729557,
0.014083747752010822,
-0.022807981818914413,
0.00971562322229147,
0.0189505722373724,
-0.028792371973395348,
-0.019238976761698723,
-0.036122649908065796,
0.00269177439622581,
0.023144453763961792,
0.02218310534954071,
-0.03278196603059769,
-0.023625126108527184,
-0.01665535382926464,
0.02672547474503517,
0.032060954719781876,
0.07330278307199478,
0.009703606367111206,
0.009415201842784882,
0.03672349452972412,
0.025740092620253563,
0.010430625639855862,
-0.004142809193581343,
-0.01723216287791729,
-0.023132435977458954,
-0.09613479673862457,
-0.01640300080180168,
-0.006218719761818647,
0.012100967578589916,
0.008207508362829685,
-0.006801537238061428,
-0.01276189461350441,
0.002331268973648548,
0.007792927324771881,
0.00218406249769032,
-0.02958548441529274,
-0.0006383951404131949,
-0.01740039885044098,
-0.0026737491134554148,
0.015982409939169884,
-0.03331070765852928,
-0.05224926397204399,
-0.03064296767115593,
0.028672203421592712,
0.007672758772969246,
0.0352814719080925,
0.009126797318458557,
0.023601092398166656,
0.02185864932835102,
0.018578050658106804,
0.015309466980397701,
0.00047804531641304493,
-0.055565912276506424,
0.010640920139849186,
-0.004956950433552265,
0.03939123451709747,
-0.01877032034099102,
0.00028671452309936285,
-0.03432012349367142,
-0.008676165714859962,
-0.013098366558551788,
-0.03991997614502907,
-0.04258771613240242,
-0.018758302554488182,
0.004788714461028576,
-0.0025490743573755026,
0.016955774277448654,
-0.04179460555315018,
0.007943137548863888,
-0.008309652097523212,
0.0020759108010679483,
-0.006537166424095631,
-0.017772920429706573,
-0.00314841466024518,
-0.0069096884690225124,
-0.02852800115942955,
-0.042395446449518204,
0.017111994326114655,
-0.009415201842784882,
0.03770887479186058,
-0.02307235263288021,
-0.05047076940536499,
0.007228135131299496,
0.0077208261936903,
-0.01642703451216221,
-0.0036200759932398796,
-0.004551381804049015,
0.07315858453512192,
0.021918734535574913,
0.012978198006749153,
0.011217729188501835,
0.0323493592441082,
-0.004545373376458883,
-0.011878656223416328,
0.027999259531497955,
-0.05489296838641167,
0.021582262590527534,
-0.01194474846124649,
-0.022399408742785454,
-0.01724417880177498,
-0.025019081309437752,
0.015009045600891113,
0.018914522603154182,
-0.009943943470716476,
0.011734453961253166,
-0.017328297719359398,
-0.014528371393680573,
-0.03218112513422966,
0.016847623512148857,
-0.038237616419792175,
0.04626487195491791,
-0.024165885522961617,
0.0013105877442285419,
-0.04136199876666069,
-0.05215312913060188,
-0.04463057965040207,
0.03948736935853958,
0.018794354051351547,
0.013831393793225288,
0.023625126108527184,
-0.05787314847111702,
0.04542369395494461,
0.00984179973602295,
-0.015706023201346397,
-0.02136595919728279,
0.02934514731168747,
-0.004996005445718765,
0.04104955866932869,
0.01085722353309393,
0.008357719518244267,
0.003124380949884653,
0.013963579200208187,
-0.03071506880223751,
-0.0013548998394981027,
-0.02095738612115383,
-0.02332470566034317,
0.0011115586385130882,
0.02088528499007225,
0.003689172910526395,
0.025019081309437752,
-0.02277193032205105,
0.038405850529670715,
0.06388157606124878,
0.052297331392765045,
-0.01202285848557949,
0.056767597794532776,
-0.05248960107564926,
-0.025884294882416725,
-0.028143461793661118,
0.009325075894594193,
0.012401388958096504,
0.01673947274684906,
-0.03314247354865074,
0.0299940574914217,
0.009979994036257267,
-0.01796519011259079,
-0.0006117327720858157,
0.012773911468684673,
0.033767346292734146,
0.0028870482929050922,
-0.011548193171620369,
-0.0064410315826535225,
-0.007564607076346874,
0.025403620675206184,
-0.0040226406417787075,
-0.014660556800663471,
-0.09911497682332993,
0.05494103580713272,
-0.0005283658392727375,
-0.03797324746847153,
-0.009901884011924267,
-0.029321113601326942,
-0.010845206677913666,
0.07719624042510986,
0.0045633986592292786,
0.07383152842521667,
0.03931913152337074,
0.021906716749072075,
0.010502726770937443,
-0.011716428212821484,
-0.026437070220708847,
-0.0552775077521801,
0.00741439638659358,
-0.012173068709671497,
0.04559192806482315,
-0.006891663186252117,
0.022795964032411575,
-0.009667555801570415,
0.005822163540869951,
0.005065102130174637,
0.02819152921438217,
0.015802158042788506,
0.009739656932651997,
-0.02797522582113743,
-0.05325867980718613,
0.024250002577900887,
-0.019959988072514534,
0.030618933960795403,
-0.0007420404581353068,
-0.04443830996751785,
0.003076313529163599,
-0.02641303651034832,
-0.020777134224772453,
-0.027590686455368996,
0.0529702752828598,
0.02233932353556156,
0.02242344245314598,
-0.05720020458102226,
-0.03064296767115593,
0.048235636204481125,
0.004097745753824711,
-0.002232129918411374,
0.009030662477016449,
0.043933603912591934,
-0.029681619256734848,
0.01373525895178318,
-0.05176858976483345,
0.0011994318338111043,
0.025619924068450928,
-0.013663158752024174,
0.003755265614017844,
-0.0482596680521965,
0.005692982580512762,
0.009595454670488834,
0.013555007055401802,
0.04357309639453888,
-0.03278196603059769,
0.011974791064858437,
-0.014708624221384525,
-0.006795528810471296,
0.008610072545707226,
0.020777134224772453,
-0.006507124286144972,
0.02063293196260929,
0.015621905215084553,
-0.06267988681793213,
0.007330278400331736,
0.001396958832629025,
0.04078518971800804,
-0.052874140441417694,
0.022627728059887886,
0.01778493821620941,
-0.023877480998635292,
0.02096940390765667,
0.04234737902879715,
-0.0370599664747715,
0.014804759062826633,
-0.03657929226756096,
0.009457261301577091,
-0.01547770295292139,
-0.046697478741407394,
0.016559218987822533,
0.026196733117103577,
0.027614720165729523,
0.010130204260349274,
0.01819351129233837,
0.007750868331640959,
-0.01011818740516901,
-0.0025520785711705685,
-0.02886447310447693,
-0.017352331429719925,
-0.009535370394587517,
0.02771085500717163,
0.03934316709637642,
-0.006068509072065353,
-0.015429635532200336,
-0.04097745940089226,
0.024502357468008995,
-0.0024198931641876698,
-0.0045633986592292786,
0.04237141087651253,
-0.01150613371282816,
0.00856801401823759,
0.016595270484685898,
0.01434811856597662,
-0.002472466789186001,
0.01317046768963337,
0.006326871458441019,
0.010917307808995247,
0.01496097818017006,
0.034680627286434174,
0.010983400978147984,
0.027734888717532158,
0.011013442650437355,
0.02022435888648033,
0.04566403105854988,
0.013110383413732052,
0.01788107305765152,
-0.013831393793225288,
-0.016535185277462006,
0.01843384839594364,
-0.025860261172056198,
-0.06690981984138489,
-0.032950203865766525,
-0.05575818195939064,
-0.014985011890530586,
-0.009367134422063828,
0.02267579548060894,
0.0051161739975214005,
-0.026917744427919388,
-0.0207290668040514,
0.015537787228822708,
-0.004719617776572704,
-0.00599340396001935,
-0.009811758063733578,
-0.021882683038711548,
-0.006206702906638384,
-0.044654615223407745,
0.04078518971800804,
-0.004488293547183275,
0.016030477359890938,
0.03023439459502697,
-0.02243545837700367,
-0.020368561148643494,
-0.010761088691651821,
0.032709866762161255,
-0.024898912757635117,
-0.026629339903593063,
0.036194752901792526,
-0.015585854649543762,
0.05330674722790718,
0.005720020737498999,
0.004551381804049015,
0.007750868331640959,
0.02535555325448513,
-0.010556802153587341,
0.017772920429706573,
-0.02583622746169567,
0.014768708497285843,
-0.02982582151889801,
0.011848613619804382,
-0.010052095167338848,
0.004854807164520025,
-0.022868065163493156,
-0.016835607588291168,
-0.055710114538669586,
-0.009403184987604618,
-0.015814173966646194,
-0.030522799119353294,
-0.018890488892793655,
0.00788906216621399,
-0.0020744088105857372,
-0.004401171114295721,
-0.0005171000957489014,
-0.005804138258099556,
0.009823774918913841,
-0.030907338485121727,
0.031075574457645416,
-0.014131815172731876,
0.007288219407200813,
-0.0038213583175092936,
-0.029801787808537483,
0.04667344316840172,
0.01738838106393814,
-0.010707013309001923,
0.01080314815044403,
-0.001882139127701521,
0.013506939634680748,
-0.006224728189408779,
-0.017676785588264465,
-0.04042468219995499,
0.05902676656842232,
-0.0012587649980559945,
0.050999511033296585,
-0.06037265434861183,
-0.01762871816754341,
-0.019851835444569588,
0.018085358664393425,
0.03403171896934509,
0.002588129136711359,
0.028143461793661118,
0.0038453920278698206,
-0.024995047599077225,
0.013362737372517586,
0.017051909118890762,
-0.03903072699904442,
-0.012894080020487309,
-0.0006879646680317819,
0.0031604315154254436,
-0.024165885522961617,
-0.030330529436469078,
-0.042876120656728745,
-0.01520131528377533,
0.033695247024297714,
0.0023447878193110228,
-0.001369920908473432,
-0.013158450834453106,
0.0020038096699863672,
0.03859812021255493,
0.029970023781061172,
-0.02780698984861374,
0.0024078763090074062,
0.01365114189684391,
0.012978198006749153,
-0.01300223171710968,
0.000927550601772964,
0.01796519011259079,
-0.022555626928806305,
-0.02291613258421421,
-0.015357534401118755,
-0.006224728189408779,
0.005515734199434519,
-0.01365114189684391,
-0.03972770646214485,
-0.0004423702775966376,
-0.0154416523873806,
-0.000850943208206445,
0.0154416523873806,
0.01121172122657299,
-0.025139249861240387,
-0.034175921231508255,
0.031339943408966064,
-0.013422821648418903,
-0.035810213536024094,
0.044342175126075745,
-0.006374938879162073,
-0.000482927163830027,
0.0049899970181286335,
-0.02087326906621456,
0.013675175607204437,
-0.006837587803602219,
-0.008628098294138908,
0.03210902214050293,
0.011566217988729477,
-0.035473741590976715,
-0.005464662332087755,
0.02022435888648033,
0.0003434190293774009,
-0.013482905924320221,
-0.04950942099094391,
0.026124631986021996,
-0.004983988590538502,
0.01843384839594364,
-0.023276638239622116,
0.011067518964409828,
-0.012749877758324146,
0.05080724135041237,
0.0659484714269638,
-0.029705652967095375,
0.01479274220764637,
-0.028552034869790077,
0.01462450623512268,
0.004488293547183275,
0.007029857020825148,
0.013591057620942593,
-0.01157823484390974,
0.015069129876792431,
-0.034416258335113525,
0.05436423048377037,
0.01651115156710148,
-0.0023853445891290903,
-0.013266602531075478,
0.002283201552927494,
0.0012167060049250722,
0.0008975084638223052,
-0.026196733117103577,
-0.040929391980171204,
0.003686168696731329,
-0.010556802153587341,
0.005635902751237154,
-0.05671953037381172,
-0.08642518520355225,
0.013386771082878113,
0.013747275806963444,
0.023192521184682846,
-0.023360755294561386,
0.005467666778713465,
-0.01869821920990944,
0.0010289427591487765,
-0.01771283708512783,
-0.013026265427470207,
-0.02445429004728794,
-0.0025310490746051073,
0.010881257243454456,
0.0003066174394916743,
-0.012449456378817558,
0.003196482080966234,
-0.020008055493235588,
0.029056742787361145,
0.009565412066876888,
0.03429608792066574,
-0.017917122691869736,
0.01624678075313568,
-0.02480277791619301,
-0.029537416994571686,
-0.015369551256299019,
-0.00018776327488012612,
0.02260369434952736,
0.012437439523637295,
0.007510531228035688,
-0.034824829548597336,
-0.01836174726486206,
-0.0011626302730292082,
-0.016559218987822533,
-0.0005212308606132865,
0.030763136222958565,
0.012894080020487309,
0.01951536349952221,
0.009763690643012524,
0.021642345935106277,
-0.025908328592777252,
0.01836174726486206,
0.04549579322338104,
0.001832569600082934,
-0.02267579548060894,
0.06772696226835251,
0.017172077670693398,
-0.0042058974504470825,
0.010208314284682274,
-0.03167641535401344,
-0.013867444358766079,
-0.005885252263396978,
-0.028023293241858482,
0.03355104476213455,
-0.024165885522961617,
-0.017124010249972343,
-0.008015238679945469,
0.0002810816222336143,
0.039054762572050095,
-0.024105800315737724,
-0.022819997742772102,
-0.0002668116067070514,
-0.0069096884690225124,
0.032541628926992416,
0.03833375126123428,
0.01625879853963852,
0.01019629742950201,
-0.014011646620929241,
0.009301042184233665,
0.008610072545707226,
0.019731666892766953,
-0.012677776627242565,
0.0030883303843438625,
-0.04950942099094391,
0.010574827902019024,
0.015009045600891113,
-0.011890673078596592,
-0.015117197297513485,
-0.031027507036924362,
0.016955774277448654,
-0.008009230718016624,
0.002084923442453146,
-0.013603074476122856,
-0.01576610654592514,
-0.00335270119830966,
0.008814359083771706,
0.0018010253552347422,
0.01657123677432537,
-0.02698984555900097,
-0.0238173957914114,
0.034896932542324066,
-0.03809341415762901,
-0.01713602803647518,
-0.0010477191535755992,
0.0040226406417787075,
0.00963751319795847,
-0.009096755646169186,
0.004908883012831211,
0.012197102420032024,
0.011608276516199112,
0.01641501672565937,
0.010839198715984821,
-0.008009230718016624,
-0.013146433979272842,
-0.0005539016565307975,
0.0194192286580801,
-0.024995047599077225,
-0.017508549615740776,
-0.02634093537926674,
0.011824579909443855,
-0.015057113021612167,
0.016186697408556938,
-0.011331889778375626,
0.018253594636917114,
0.047418490052223206,
-0.11257384717464447,
-0.0473223552107811,
-0.010346507653594017,
0.0013503935188055038,
-0.029321113601326942,
0.008339693769812584,
-0.03732433542609215,
-0.006122584920376539,
-0.00727620255202055,
-0.01975570060312748,
-0.0011295839212834835,
-0.03972770646214485,
0.009289025329053402,
-0.009805749170482159,
-0.003247553715482354,
0.012239161878824234,
-0.019947970286011696,
-0.022050919011235237,
0.009871842339634895,
0.044894952327013016,
-0.02373327873647213,
0.01373525895178318,
0.007101958151906729,
0.043597131967544556,
0.006609267555177212,
-0.003680160269141197,
-0.03398365154862404,
-0.017364347353577614,
-0.05388355627655983,
-0.012629709206521511,
-0.00036895484663546085,
-0.001198680722154677,
-0.010166254825890064,
0.025788160040974617,
-0.02835976518690586,
-0.052778005599975586,
0.02756665274500847,
0.004326066002249718,
-0.0020699023734778166,
0.002056383527815342,
-0.009829782880842686,
0.009571420960128307,
0.02658127248287201,
0.010034069418907166,
-0.015213332138955593,
0.0016793548129498959,
-0.040280479937791824,
0.005494704470038414,
-0.0023057330399751663,
-0.0055878353305161,
0.009228941053152084,
-0.020272426307201385,
-0.02259167842566967,
0.0026902721729129553,
-0.010466676205396652,
-0.04249158129096031,
0.012665759772062302,
0.013458872213959694,
0.001246748142875731,
0.02511521615087986,
-0.021978817880153656,
0.04835580289363861,
0.016631320118904114,
-0.03347894549369812,
0.00889847707003355,
-0.012497523799538612,
-0.01827762834727764,
0.017268212512135506,
-0.03593038022518158,
-0.003355705412104726,
-0.011512142606079578,
0.008417803794145584,
-0.05152825266122818,
0.024971013888716698,
-0.013458872213959694,
-0.002134492853656411,
-0.027326317504048347,
-0.027831023558974266,
0.017328297719359398,
0.022567644715309143,
-0.025379586964845657,
-0.021522177383303642,
0.0006342643755488098,
0.03754064068198204,
-0.020380577072501183,
0.024009665474295616,
-0.011530167423188686,
0.0255958903580904,
0.022411424666643143,
-0.01113361120223999,
-0.004386150278151035,
-0.014852826483547688,
0.01624678075313568,
0.018157459795475006,
0.004509322810918093,
-0.017111994326114655,
-0.03477676212787628,
-0.0036020507104694843,
-0.009763690643012524,
-0.009481295011937618,
0.026533205062150955,
-0.0534990169107914,
0.000711998378392309,
-0.025403620675206184,
-0.034344155341386795,
0.016595270484685898,
0.013795343227684498,
-0.012040883302688599,
0.007119983434677124,
-0.007636708207428455,
0.019863853231072426,
-0.0064169978722929955,
0.013711226172745228,
0.02607656456530094,
0.010442642495036125,
0.010610878467559814,
0.029080776497721672,
-0.03684366121888161,
0.015285433270037174,
0.023024285212159157,
0.05647919327020645,
0.028239596635103226,
-0.01827762834727764,
-0.023516975343227386,
-0.02315646968781948,
0.006627292837947607,
0.010148230008780956,
-0.008922510780394077,
0.0024123825132846832,
0.002496500499546528,
0.029729686677455902,
0.007396371103823185,
-0.007065907586365938,
0.0029321112670004368,
-0.0075585986487567425,
0.03657929226756096,
0.049365218728780746,
0.01586224138736725,
0.00012214001617394388,
0.006453048437833786,
0.007702800910919905,
-0.0013120898511260748,
-0.0023507962469011545,
0.0018340717069804668,
0.0429241880774498,
-0.014516354538500309,
-0.05095144361257553,
0.020464695990085602,
0.008057298138737679,
0.02747051790356636,
-0.032229192554950714,
0.018025275319814682,
0.04708201810717583,
0.05354708433151245,
0.003965560346841812,
0.015718039125204086,
0.037011899054050446,
-0.03258969634771347,
-0.0417705699801445,
0.0022816993296146393,
-0.03374331444501877,
0.03419995307922363,
-0.02236335724592209,
-0.03292616829276085,
0.010538777336478233,
-0.013254585675895214,
-0.014011646620929241,
0.022243188694119453,
0.0006278803921304643,
0.039799805730581284,
0.024995047599077225,
-0.02185864932835102,
0.06085332855582237,
-0.008880452252924442,
-0.0335029773414135,
0.004620478954166174,
0.0032415452878922224,
0.01523736584931612,
0.005626889877021313,
0.02260369434952736,
-0.01049070991575718,
0.004536360967904329,
-0.007005823310464621,
0.002138999290764332,
0.03893459215760231,
-0.00460846209898591,
0.007895070128142834,
-0.01975570060312748,
0.029441282153129578,
-0.023108402267098427,
0.008339693769812584,
-0.03242146223783493,
-0.010010035708546638,
0.061237867921590805,
0.04496705159544945,
-0.025884294882416725,
-0.03453642502427101,
-0.0067895203828811646,
-0.041818637400865555,
-0.05239346623420715,
-0.012497523799538612,
0.060276519507169724,
0.05575818195939064,
-0.017496533691883087,
-0.024358155205845833,
0.034344155341386795,
-0.004605457652360201,
-0.045712098479270935,
0.0221951212733984,
0.04299628734588623,
0.008417803794145584,
0.020020071417093277,
-0.05239346623420715,
0.009289025329053402,
-0.012263195589184761,
0.0075345649383962154,
-0.00005487381713464856,
-0.005278401076793671,
-0.034824829548597336,
-0.02202688530087471,
-0.038646187633275986,
-0.05835382267832756,
0.01780897192656994,
-0.0009252974414266646,
-0.0101542379707098,
0.0072822109796106815,
0.02862413600087166,
0.024237986654043198,
0.0038694257382303476,
0.02477874420583248,
-0.01012419629842043,
0.0205728467553854,
0.018818387761712074,
-0.007246160414069891,
0.005846197251230478,
0.0006530407117679715,
-0.005569810047745705,
-0.03903072699904442,
0.034920964390039444,
-0.0033887517638504505,
0.03338281065225601,
0.020608898252248764,
0.012275212444365025,
-0.021438060328364372,
-0.009937934577465057,
-0.011482100002467632,
0.05378742143511772,
-0.024526391178369522,
-0.03917492926120758,
0.00018119157175533473,
-0.022892098873853683,
0.004085728898644447,
0.01999603770673275,
0.04302032291889191,
0.04136199876666069,
-0.01207693386822939,
0.0023703237529844046,
0.01133789774030447,
0.03573811054229736,
0.010010035708546638,
0.0017995232483372092,
0.002923098625615239,
-0.021161671727895737,
-0.02236335724592209,
0.021654363721609116,
0.0064169978722929955,
-0.003481882158666849,
-0.023589076474308968,
0.010598861612379551,
0.030498765408992767,
0.03184465318918228,
0.026917744427919388,
-0.0015073636313900352,
0.009072721935808659,
-0.014071730896830559,
-0.002083421451970935,
0.03186868503689766,
-0.0009230442810803652,
0.012287229299545288,
-0.00402564462274313,
-0.019947970286011696,
-0.020452678203582764,
-0.004542369395494461,
0.0018220548518002033,
-0.0024469310883432627,
0.02446630597114563,
-0.026941778138279915,
-0.0320369228720665,
-0.001534401555545628,
-0.02243545837700367,
-0.03316650539636612,
-0.001903168624266982,
-0.03290213644504547,
-0.016559218987822533,
0.0009207911207340658,
-0.012785928323864937,
-0.008039272390305996,
0.01043663453310728,
0.010334490798413754,
-0.024995047599077225,
-0.010917307808995247,
0.02545168809592724,
-0.005927311256527901,
-0.021810581907629967,
0.002869023010134697,
-0.023348739370703697,
-0.020176291465759277,
-0.03513726964592934,
0.027614720165729523,
-0.009228941053152084,
-0.054316163063049316,
0.03307037055492401,
-0.004605457652360201,
0.00039918473339639604,
0.03470466285943985,
0.020452678203582764,
-0.012858029454946518,
0.02081318385899067,
0.010214322246611118,
0.01344685535877943,
-0.006783511955291033,
0.00021724210819229484,
0.011091552674770355,
-0.028143461793661118,
-0.013254585675895214,
0.011890673078596592,
0.005068106576800346,
-0.013567023910582066,
0.001345887198112905,
0.0011678875889629126,
0.019311077892780304,
-0.01738838106393814,
-0.01219109445810318,
0.0056809657253324986,
0.01141600776463747,
0.00007627883314853534,
-0.0038273667450994253,
-0.01259365864098072,
0.00009449187200516462,
0.0021465097088366747,
-0.016943758353590965,
-0.007180067710578442,
0.015021062456071377,
0.021197723224759102,
0.01475669164210558,
0.008483896031975746,
-0.033358775079250336,
-0.04568806290626526,
-0.025091182440519333,
-0.029537416994571686,
0.05748860910534859,
-0.020500745624303818,
-0.04268385097384453,
0.04314048960804939,
0.02333672158420086,
0.0014074735809117556,
0.011518150568008423,
0.021101588383316994,
-0.004809744190424681,
0.0145524051040411,
-0.029849855229258537,
0.02624480053782463,
0.039054762572050095,
-0.019082756713032722,
0.016354933381080627,
0.01764073595404625,
-0.003373730694875121,
-0.0027849050238728523,
-0.006597250699996948,
0.022711846977472305,
0.021822599694132805,
-0.004124783910810947,
-0.027037912979722023,
-0.02463454194366932,
0.021834615617990494,
0.020668981596827507,
0.0026016479823738337,
-0.006386955734342337,
0.004692580085247755,
0.030691035091876984,
0.004770689178258181,
-0.005338485352694988,
0.0040226406417787075,
-0.010214322246611118,
-0.0031994862947613,
-0.04297225549817085,
-0.04626487195491791,
-0.019803768023848534,
0.007600657641887665,
0.021666379645466805,
0.012197102420032024,
-0.009907892905175686,
0.002496500499546528,
0.0075585986487567425,
-0.029032709077000618,
-0.004434217698872089,
-0.009078729897737503,
0.0008952553034760058,
-0.022447476163506508,
0.0029666598420590162,
-0.028816405683755875,
-0.032541628926992416,
0.011289830319583416,
-0.021402008831501007,
0.01586224138736725,
0.021522177383303642,
0.00521831726655364,
0.02325260452926159,
0.004794722888618708,
-0.006657334975898266,
-0.007666750345379114,
-0.024826811626553535,
-0.07282210886478424,
0.012425422668457031,
-0.025716058909893036,
0.020668981596827507,
-0.0009283016552217305,
-0.021894700825214386,
-0.017532583326101303,
-0.01373525895178318,
-0.0015396588714793324,
-0.017124010249972343,
-0.017087960615754128,
-0.009000620804727077,
-0.006555191706866026,
-0.011788529343903065,
0.0021720456425100565,
0.004776697605848312,
-0.0177969541400671,
0.025139249861240387,
-0.004554386250674725,
-0.0059573533944785595,
0.0077088093385100365,
-0.003947535064071417,
-0.03326264023780823,
-0.0013323682360351086,
-0.021005453541874886,
0.011079535819590092,
-0.034512393176555634,
0.0020518770907074213,
-0.007498514372855425,
-0.012930130586028099,
0.03429608792066574,
0.022807981818914413,
0.004241948015987873,
-0.013891478069126606,
-0.01713602803647518,
-0.011001425795257092,
0.014948961324989796,
0.01482879277318716,
0.013699209317564964,
0.034993067383766174,
-0.012569624930620193,
-0.003538962220773101,
-0.022291256114840508,
0.0016297852853313088,
-0.019383179023861885,
-0.03283003345131874,
0.0012009339407086372,
0.04020838066935539,
-0.033935584127902985,
-0.008586038835346699,
-0.02600446343421936,
0.011127603240311146,
0.016282832249999046,
0.013470889069139957,
0.0017139032715931535,
-0.0039986069314181805,
-0.03371928259730339,
-0.0017995232483372092,
0.003229528432711959,
0.012617692351341248,
0.012329287827014923,
0.02576412633061409,
0.04388553649187088,
-0.029465315863490105,
-0.008730241097509861,
0.010430625639855862,
-0.0012925624614581466,
0.001396958832629025,
-0.030739102512598038,
0.0028404828626662493,
-0.0024980027228593826,
-0.011824579909443855,
0.013819376938045025,
0.03162834793329239,
0.009571420960128307,
-0.02975372038781643,
-0.00010111052688444033,
0.023204537108540535,
-0.01150613371282816,
0.004596445243805647,
-0.023769328370690346,
0.008009230718016624,
-0.017087960615754128,
0.006113572511821985,
-0.012401388958096504,
-0.01916687563061714,
-0.008718224242329597,
-0.0021179697941988707,
-0.008507929742336273,
-0.009601462632417679,
-0.006242753472179174,
-0.009805749170482159,
0.009078729897737503,
-0.003731231903657317,
-0.02754261903464794,
-0.058401890099048615,
0.017604684457182884,
0.01238937210291624,
-0.02225520648062229,
-0.011500125750899315,
-0.013795343227684498,
0.017700819298624992,
0.03131591156125069,
-0.015417618677020073,
-0.024995047599077225,
0.027278250083327293,
0.017111994326114655,
-0.013639125041663647,
0.006549183279275894,
0.026605306193232536,
0.03081120364367962,
-0.03982384130358696,
-0.015802158042788506,
-0.021065538749098778,
-0.000032647341868141666,
0.04191477224230766,
-0.02163033001124859,
0.013675175607204437,
0.02545168809592724,
-0.011650335974991322,
0.021149655804038048,
-0.0032084989361464977,
-0.004103754181414843,
0.03984787315130234,
-0.002365817315876484,
-0.01154218427836895,
-0.018505949527025223,
-0.01255760807543993,
-0.02112562209367752,
0.012040883302688599,
0.018974605947732925,
-0.03302230313420296,
0.012263195589184761,
0.0022065939847379923,
0.015994427725672722,
-0.01296618115156889,
0.004253964871168137,
0.025499755516648293,
0.03131591156125069,
0.0038514004554599524,
-0.0013496424071490765,
0.017532583326101303,
0.004866824019700289,
-0.026605306193232536,
0.0015967389335855842,
0.010004027746617794,
-0.03730030357837677,
-0.0008922510896809399,
-0.004247956443578005,
0.009072721935808659,
-0.0223513413220644,
0.01648711785674095,
-0.0062667871825397015,
-0.00870019942522049,
-0.012858029454946518,
-0.02113763801753521,
-0.045375626534223557,
-0.013326686806976795,
-0.0429241880774498,
-0.025812193751335144,
-0.0033917559776455164,
-0.030835237354040146,
0.002534053288400173,
0.012689793482422829,
-0.0010109174763783813,
0.0007983694667927921,
0.0020759108010679483,
-0.01085722353309393,
-0.006350905168801546,
-0.010148230008780956,
-0.02185864932835102,
0.024009665474295616,
-0.01673947274684906,
-0.02958548441529274,
-0.03960753604769707,
-0.009685580618679523,
-0.0011491113109514117,
0.0025235384237021208,
-0.057104069739580154,
-0.0012940645683556795,
0.020212341099977493,
-0.04064098745584488,
0.0024980027228593826,
0.034896932542324066,
-0.0007968673598952591,
-0.008303643204271793,
-0.04460654780268669,
0.018878471106290817,
-0.021426042541861534,
0.014408202841877937,
0.0035780170001089573,
-0.01390349492430687,
-0.005020039156079292,
-0.013290636241436005,
-0.0282155629247427,
-0.0038784383796155453,
-0.005176258273422718,
0.015946360304951668,
-0.011614285409450531,
0.00751653965562582,
0.022411424666643143,
0.00365612655878067,
0.011037476360797882,
0.009541378356516361,
-0.02032049372792244,
-0.015465686097741127,
0.002745850244536996,
0.008399778045713902,
0.01852998323738575,
0.028888506814837456,
-0.017532583326101303,
-0.002613664837554097,
0.012942147441208363,
0.01975570060312748,
-0.010947350412607193,
-0.005326468497514725,
0.027158081531524658,
-0.026941778138279915,
-0.006831579376012087,
0.025716058909893036,
0.00497798016294837,
-0.025235384702682495,
-0.014852826483547688,
-0.025019081309437752,
-0.0020668981596827507,
0.009805749170482159,
-0.008598055690526962,
0.0028509977273643017,
-0.024754710495471954,
-0.0046324958093464375,
0.01974368467926979,
-0.0019902908243238926,
-0.035954415798187256,
0.032637763768434525,
-0.003980581648647785,
0.008892469108104706,
0.015898292884230614,
-0.016210731118917465,
-0.012365338392555714,
0.038165513426065445,
0.005032056011259556,
-0.002466458361595869,
0.013963579200208187,
0.02374529466032982,
-0.016066528856754303,
0.007029857020825148,
0.006125589367002249,
-0.01771283708512783,
0.03903072699904442,
0.0019392191898077726,
-0.014864843338727951,
0.032133057713508606,
0.011355923488736153,
-0.011518150568008423,
0.0007803441840223968,
-0.005464662332087755,
-0.018890488892793655,
-0.00416684290394187,
-0.029080776497721672,
-0.0119868079200387,
-0.01560988835990429,
-0.011067518964409828,
0.11468881368637085,
0.0030627946835011244,
0.026124631986021996,
0.01642703451216221,
-0.002359808888286352,
-0.03006615862250328,
0.013699209317564964,
0.006236745044589043,
0.018169477581977844,
-0.035641975700855255,
0.02723018266260624,
0.012251178734004498,
0.025307485833764076,
0.01640300080180168,
0.02006813883781433,
-0.03179658576846123,
0.0051402077078819275,
0.0523453988134861,
-0.01341080479323864,
-0.007750868331640959,
-0.001975269755348563,
0.00216453499160707,
-0.024562440812587738,
0.03578617796301842,
-0.03138801082968712,
-0.040761154145002365,
-0.0002848368894774467,
-0.013146433979272842,
-0.020500745624303818,
-0.01341080479323864,
0.025019081309437752,
0.014516354538500309,
0.028720270842313766,
-0.015261399559676647,
-0.003253562143072486,
-0.020500745624303818,
-0.02024839259684086,
-0.010292432270944118,
0.0323493592441082,
0.008664148859679699,
-0.00572602916508913,
0.02610059827566147,
0.012281220406293869,
0.018830403685569763,
0.0052994308061897755,
-0.009150831028819084,
-0.02081318385899067,
-0.00812339037656784,
-0.004142809193581343,
-0.005326468497514725,
-0.024478323757648468,
-0.015261399559676647,
0.026437070220708847,
-0.0020864256657660007,
-0.011632310226559639,
-0.0161746796220541,
0.028407832607626915,
-0.001334621338173747,
-0.013891478069126606,
-0.028503967449069023,
-0.01019629742950201,
-0.010881257243454456,
0.0045633986592292786,
0.013470889069139957,
0.021810581907629967
] | 2024-07-03 | 41 | 38955421 | [
"A20 tumor cells",
"Adoptive cell therapy",
"B cell malignancy patients",
"established A20 B cell lymphoma",
"anti-mouse CD19 CAR-T cells",
"CD19 CAR-T cells",
"Conventional CD19 CAR-T cells",
"potential toxicity",
"CAR-T cell transfer",
"CD19/mbIL15q CAR-T cell transfer",
"CAR-T cells",
"genetically modified T cells",
"the modified T cells",
"prolonged persistence",
"low persistence",
"CAR-T therapy",
"inadequate persistence",
"IL15",
"vivo efficacy",
"poor efficacy",
"immunocompetent mice",
"NSG mice",
"antitumor efficacy",
"Mice survival",
"mild lymphodepletion regimens",
"significant inflammatory findings",
"total body irradiation",
"CAR-T",
"CD19/mbIL15q CAR-T",
"transaminase elevations"
] | [
"Adoptive cell therapy - ACT",
"Chimeric antigen receptor - CAR",
"Cytokine",
"Hematologic Malignancies",
"Immune related adverse event - irAE"
] | 0 | 10.1136/jitc-2023-008572
10.1200/JCO.2014.56.2025
10.1056/NEJMoa1407222
10.1056/NEJMoa1707447
10.1056/NEJMoa1804980
10.1056/NEJMoa1708566
10.1186/s13045-020-01001-1
10.1016/j.cmet.2017.06.016
10.1172/JCI125423
10.1158/2326-6066.CIR-18-0466
10.1182/blood-2012-05-431718
10.1182/blood-2015-11-683847
10.1002/acg2.84
10.1016/s1074-7613(00)80564-6
10.1073/pnas.0307298101
10.1136/jitc-2020-001229
10.1158/2326-6066.CIR-19-0293
10.1158/1078-0432.CCR-18-1811
10.1038/leu.2010.75
10.1158/2326-6066.CIR-16-0376
10.1200/JCO.2014.57.3329
10.1073/pnas.1610544113
10.1136/jitc-2021-004479
10.4049/jimmunol.1001114
10.3389/fimmu.2019.02990
10.1182/blood-2011-04-348540
10.1016/j.omto.2017.12.003
10.1371/journal.pone.0166280
10.1158/2159-8290.CD-16-0040
10.1038/s41467-017-00965-y
10.1126/scitranslmed.3007240
10.1111/j.1600-065X.2008.00604.x
10.1007/s10875-011-9586-7
10.1161/STROKEAHA.119.028638
10.1016/j.ccr.2012.09.009
10.1158/2159-8290.CD-15-1297
10.1084/jem.193.2.219
10.1182/blood-2010-09-307504
10.1186/s12967-022-03626-x
10.1101/cshperspect.a028449
10.1016/j.micinf.2011.10.006
10.1126/sciadv.adj6251 | [
"Sánchez-Moreno",
"Lasarte-Cia",
"Martín-Otal",
"Casares",
"Navarro",
"Gorraiz",
"Sarrión",
"Hervas-Stubbs",
"Jordana",
"Rodriguez-Madoz",
"San Miguel",
"Prosper",
"Lasarte",
"Lozano"
] | [
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain.",
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain.",
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain.",
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain.",
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain.",
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain.",
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain.",
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain.\nCancer Center Universidad de Navarra (CCUN), Pamplona, Spain.",
"Hemato-Oncology Program, Centre for Applied Medical Research (CIMA), University of Navarra, IdiSNA, Pamplona, Spain.",
"Cancer Center Universidad de Navarra (CCUN), Pamplona, Spain.\nHemato-Oncology Program, Centre for Applied Medical Research (CIMA), University of Navarra, IdiSNA, Pamplona, Spain.",
"Cancer Center Universidad de Navarra (CCUN), Pamplona, Spain.\nHematology and Cell Therapy Department, Clínica Universidad de Navarra, (CUN), Pamplona, Spain.\nCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.",
"Cancer Center Universidad de Navarra (CCUN), Pamplona, Spain.\nHemato-Oncology Program, Centre for Applied Medical Research (CIMA), University of Navarra, IdiSNA, Pamplona, Spain.\nHematology and Cell Therapy Department, Clínica Universidad de Navarra, (CUN), Pamplona, Spain.\nCentro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.",
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain [email protected].\nCancer Center Universidad de Navarra (CCUN), Pamplona, Spain.",
"Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, IdISNA, Pamplona, Spain.\nCancer Center Universidad de Navarra (CCUN), Pamplona, Spain."
] | [
"38955421",
"25154820",
"25317870",
"29226797",
"30501490",
"29226764",
"33272302",
"28683298",
"30860496",
"30890531",
"23160470",
"27226436",
"9620680",
"14762166",
"32938629",
"31953246",
"30617136",
"20428207",
"28550091",
"25403209",
"27849617",
"35918123",
"20870946",
"31921216",
"21849486",
"29367945",
"27855183",
"27076371",
"29109393",
"24648340",
"18364014",
"21938511",
"32019481",
"23153537",
"27422033",
"11208862",
"21304101",
"36167591",
"29038115",
"22064066",
"38394207"
] | [] | 7.550119 | 5.340172 |
38954005 | 783 | Impact of fludarabine and treosulfan on ovarian tumor cells and mesothelin chimeric antigen receptor T cells. | In addition to their immunosuppressive effect, cytostatics conditioning prior to adoptive therapy such as chimeric antigen receptor (CAR) T cells may play a role in debulking and remodeling the tumor microenvironment. We investigated in vitro the killing efficacy and impact of treosulfan and fludarabine on ovarian cancer cells expressing mesothelin (MSLN) and effect on MSLN-targeting CAR T cells. Treosulfan and fludarabine had a synergetic effect on killing of SKOV3 and OVCAR4 cells. Sensitivity to the combination of treosulfan and fludarabine was increased when SKOV3 cells expressed MSLN and when OVCAR4 cells were tested in hypoxia, while MSLN cells surface expression by SKOV3 and OVCAR4 cells was not altered after treosulfan or fludarabine exposure. Exposure to treosulfan or fludarabine (10 µM) neither impacted MSLN-CAR T cells degranulation, cytokines production upon challenge with MSLN + OVCAR3 cells, nor induced mitochondrial defects. Combination of treosulfan and fludarabine decreased MSLN-CAR T cells anti-tumor killing in normoxia but not hypoxia. In conclusion, treosulfan and fludarabine killed MSLN + ovarian cancer cells without altering MSLN-CAR T cells functions (at low cytostatics concentration) even in hypoxic conditions, and our data support the use of treosulfan and fludarabine as conditioning drugs prior to MSLN-CAR T cell therapy. | [
0.007079932373017073,
0.004564693197607994,
0.0435614176094532,
0.0272859875112772,
-0.018595341593027115,
-0.00664119329303503,
0.037503208965063095,
-0.0031943838112056255,
-0.00580879021435976,
0.012224603444337845,
-0.01765776053071022,
-0.02586759813129902,
-0.04089292138814926,
0.04019574448466301,
-0.009496004320681095,
-0.008558424189686775,
0.040965043008327484,
-0.017525536939501762,
-0.006022149696946144,
-0.00262943166308105,
0.05010043829679489,
0.014075723476707935,
-0.02328324131667614,
-0.0014161367435008287,
-0.03723876178264618,
-0.00560144055634737,
0.04240747541189194,
0.020218076184391975,
0.01361895352602005,
-0.01512148603796959,
0.03098822757601738,
-0.0248578954488039,
-0.032214295119047165,
-0.0014845019904896617,
-0.016768261790275574,
0.007909330539405346,
0.026997501030564308,
0.029377512633800507,
-0.017633719369769096,
-0.051542870700359344,
0.0545719750225544,
0.0021816769149154425,
0.007668925449252129,
0.07361206412315369,
0.0042882272973656654,
0.018258772790431976,
0.02656477317214012,
-0.07197730988264084,
0.0326470248401165,
0.003056150861084461,
-0.004104918334633112,
-0.013234305195510387,
-0.020891210064291954,
0.03752724826335907,
-0.05697602778673172,
-0.020554643124341965,
-0.020506562665104866,
0.00979050062596798,
0.0007448804099112749,
-0.017104828730225563,
-0.01653987728059292,
-0.03570016846060753,
0.03428177908062935,
-0.018607361242175102,
-0.07327549904584885,
-0.020302217453718185,
0.010800202377140522,
-0.029209230095148087,
0.012561170384287834,
0.006358717102557421,
0.01130505371838808,
-0.020434441044926643,
0.06394777446985245,
0.012573190964758396,
0.028127405792474747,
-0.020133933052420616,
0.033223994076251984,
0.02774275839328766,
0.02661285363137722,
-0.06077443063259125,
0.05875502526760101,
-0.014412290416657925,
0.03752724826335907,
-0.00397870596498251,
-0.014195925556123257,
0.027838919311761856,
0.007879279553890228,
-0.0015115475980564952,
-0.04334505274891853,
0.015542195178568363,
-0.07962219417095184,
0.009111355990171432,
-0.007296297233551741,
0.016756240278482437,
-0.009652268141508102,
0.019208373501896858,
0.03127671405673027,
-0.05611056834459305,
0.004068857524544001,
0.014544513076543808,
0.01330642681568861,
0.008450241759419441,
0.001544603263027966,
-0.0030831964686512947,
0.03781573474407196,
0.003299561096355319,
-0.028800541535019875,
-0.03776765242218971,
0.04065251722931862,
0.026011841371655464,
0.09053659439086914,
-0.01711684837937355,
0.007620844058692455,
0.02940155379474163,
-0.007987461984157562,
-0.04526829719543457,
-0.06567869335412979,
0.006845537573099136,
0.00697776023298502,
0.013041981495916843,
-0.055004704743623734,
-0.008498323149979115,
-0.004723961930721998,
0.01819867268204689,
0.00822786707431078,
-0.020506562665104866,
0.11154800653457642,
-0.03548380360007286,
-0.01885978691279888,
-0.0684673935174942,
0.021648487076163292,
-0.014905121177434921,
-0.01840301603078842,
-0.05591824650764465,
-0.044883646070957184,
-0.0008248902740888298,
-0.025915678590536118,
0.010427574627101421,
0.012278694659471512,
0.03990726172924042,
0.04226323217153549,
-0.04644628241658211,
-0.017922205850481987,
-0.0008759764023125172,
-0.03918604552745819,
-0.0560624897480011,
-0.009808531031012535,
0.0668807178735733,
0.009652268141508102,
0.019809387624263763,
-0.024353044107556343,
0.01760968007147312,
0.07635268568992615,
0.02956983633339405,
0.01076414156705141,
-0.009934743866324425,
0.020386358723044395,
0.03747916594147682,
-0.005003432743251324,
-0.0637073740363121,
-0.001085579628124833,
0.022105256095528603,
0.004119943827390671,
-0.03416157513856888,
0.03923412412405014,
-0.014941181987524033,
0.009375802241265774,
0.0499081164598465,
-0.04531637579202652,
-0.0017143894219771028,
-0.023631829768419266,
-0.015602296218276024,
-0.06947709619998932,
-0.027502352371811867,
-0.07337166368961334,
-0.00888898130506277,
0.004444490652531385,
-0.019641103222966194,
-0.01824675314128399,
0.0091654472053051,
-0.01637159287929535,
0.04885033145546913,
0.016395634040236473,
0.021636465564370155,
-0.03202196955680847,
-0.012549150735139847,
-0.03745512664318085,
0.019004030153155327,
-0.02969004027545452,
0.03223833441734314,
0.008498323149979115,
-0.04134969040751457,
-0.0028758470434695482,
0.03627714142203331,
-0.0010495188180357218,
-0.007122003473341465,
0.01885978691279888,
0.002390529029071331,
-0.030122769996523857,
-0.004071862902492285,
0.05024468153715134,
-0.013703095726668835,
-0.0034828700590878725,
0.010337422601878643,
-0.012332785874605179,
-0.03223833441734314,
-0.00945393368601799,
0.002961491234600544,
0.005388081073760986,
0.04594143107533455,
0.03832058608531952,
0.03502703458070755,
-0.028055284172296524,
0.012218593619763851,
0.009934743866324425,
-0.02944963425397873,
0.002210225211456418,
-0.0019532921724021435,
0.05221600458025932,
-0.037671491503715515,
-0.009063275530934334,
-0.027478311210870743,
0.018763624131679535,
0.03257490321993828,
-0.036012694239616394,
-0.0027932077646255493,
-0.014700776897370815,
0.0053369952365756035,
0.02598780021071434,
-0.035171277821063995,
0.010229240171611309,
-0.015421992167830467,
0.0046518403105437756,
0.0010683005675673485,
-0.030002566054463387,
-0.03610885888338089,
-0.032214295119047165,
0.0032184242736548185,
0.009057264775037766,
-0.00019645610882434994,
-0.012885717675089836,
0.020975351333618164,
0.05284105986356735,
-0.01239288691431284,
-0.019316555932164192,
0.011226922273635864,
-0.007771097589284182,
-0.07842016965150833,
-0.020458480343222618,
0.008786809630692005,
-0.029930444434285164,
0.0012523607583716512,
-0.01333046704530716,
-0.014857039786875248,
-0.011383185163140297,
-0.011851975694298744,
0.03747916594147682,
-0.022766370326280594,
0.0035069105215370655,
-0.03894563764333725,
0.027189826592803,
-0.010565808042883873,
-0.031300753355026245,
-0.051831357181072235,
-0.06346696615219116,
0.01339056808501482,
-0.023355362936854362,
0.0017955262446776032,
0.010523736476898193,
0.012885717675089836,
0.033127833157777786,
-0.0024040518328547478,
0.031469039618968964,
-0.030603580176830292,
-0.05163903161883354,
-0.00502747343853116,
0.022093236446380615,
0.04002746194601059,
0.006370737217366695,
0.0024265898391604424,
0.01899200864136219,
-0.013823297806084156,
0.007993471808731556,
-0.0452442541718483,
-0.0006821497227065265,
0.0008376617915928364,
0.029089026153087616,
0.016960585489869118,
0.011761823669075966,
-0.01840301603078842,
-0.04735982045531273,
0.004823129158467054,
0.030603580176830292,
0.00020885199774056673,
-0.04743194207549095,
-0.0011802391381934285,
-0.034257739782333374,
-0.0053730555810034275,
-0.036253102123737335,
0.028848621994256973,
0.007073922548443079,
0.055581677705049515,
-0.022477883845567703,
-0.00791534036397934,
0.015650376677513123,
0.03156520053744316,
0.037551287561655045,
-0.010613888502120972,
0.0190280694514513,
0.05024468153715134,
0.046734768897295,
0.01620330847799778,
0.020915251225233078,
0.02548294886946678,
0.05750491842627525,
0.023715971037745476,
0.03372884541749954,
-0.0003097094886470586,
-0.00023232906823977828,
-0.034546226263046265,
0.0002875471254810691,
-0.041590094566345215,
-0.021432122215628624,
-0.01733321323990822,
0.008011502213776112,
-0.04447495937347412,
0.04899457469582558,
0.01953292079269886,
0.0009405852761119604,
-0.025218503549695015,
0.0033025662414729595,
-0.020097872242331505,
0.02656477317214012,
-0.037791695445775986,
0.001794023672118783,
0.0051266406662762165,
-0.029714079573750496,
-0.031012268736958504,
0.050869736820459366,
0.0008714688010513783,
-0.012170512229204178,
-0.0241607204079628,
-0.013090061955153942,
0.03310379385948181,
-0.040916960686445236,
-0.006304625887423754,
-0.025506990030407906,
-0.001975830178707838,
0.026636894792318344,
0.02223747968673706,
0.029834283515810966,
-0.0049102758057415485,
-0.026997501030564308,
0.006689274217933416,
-0.007458570878952742,
0.031420957297086716,
-0.028079325333237648,
-0.026709016412496567,
0.02603588066995144,
0.00302009005099535,
0.029978526756167412,
-0.02978620119392872,
-0.04026786610484123,
0.029353473335504532,
0.040796760469675064,
0.0458933487534523,
0.003813427174463868,
0.059043511748313904,
-0.060726348310709,
-0.034209657460451126,
-0.014857039786875248,
-0.014712797477841377,
0.029762161895632744,
-0.009796511381864548,
-0.03166136145591736,
0.031060349196195602,
0.007975441403687,
-0.014195925556123257,
0.032887428998947144,
0.0029209230560809374,
0.061784129589796066,
-0.02315101958811283,
-0.01083025336265564,
-0.020879190415143967,
-0.04615779593586922,
-0.022958694025874138,
0.033223994076251984,
-0.012897738255560398,
-0.05692794546484947,
-0.0009157934691756964,
0.010187169536948204,
0.001969819888472557,
0.035844411700963974,
0.004396409727632999,
-0.020386358723044395,
0.09457539767026901,
-0.016636038199067116,
0.10135482251644135,
0.048417601734399796,
-0.011755812913179398,
0.007368418853729963,
-0.033055711537599564,
-0.026204165071249008,
0.007753067184239626,
-0.003807417117059231,
-0.001999870641157031,
0.02377607300877571,
-0.040171705186367035,
0.01623936928808689,
-0.014256027527153492,
-0.05822613462805748,
0.01694856584072113,
0.029016904532909393,
-0.011984198354184628,
0.016563916578888893,
-0.019124232232570648,
-0.024881936609745026,
0.0622168593108654,
-0.003479864913970232,
0.050581250339746475,
0.03822442516684532,
-0.013570872135460377,
0.03743108734488487,
-0.043080609291791916,
0.02024211548268795,
0.016059065237641335,
0.009003173559904099,
-0.05486046150326729,
-0.0085824653506279,
-0.08101654797792435,
-0.007813168689608574,
0.06067826598882675,
0.009844591841101646,
-0.005796770099550486,
0.030002566054463387,
0.04317677021026611,
-0.051206301897764206,
-0.002731603803113103,
-0.052504491060972214,
0.03007468767464161,
-0.02956983633339405,
0.00536404037848115,
0.002657979726791382,
-0.04610971361398697,
-0.00505151366814971,
-0.0002565573959145695,
0.03406541422009468,
0.030291052535176277,
-0.026997501030564308,
0.0035700169391930103,
0.047119416296482086,
-0.038921598345041275,
-0.021347980946302414,
0.039089880883693695,
0.010277321562170982,
-0.04873013123869896,
0.028175486251711845,
-0.061447564512491226,
0.07803551852703094,
0.02024211548268795,
0.044042229652404785,
-0.014676736667752266,
-0.03202196955680847,
-0.03406541422009468,
0.0048141139559447765,
0.030218930914998055,
0.04526829719543457,
0.016131186857819557,
0.038633111864328384,
-0.007819178514182568,
0.023307282477617264,
-0.02603588066995144,
-0.04009958356618881,
0.0499081164598465,
0.011695711873471737,
-0.04077271744608879,
0.0010442599887028337,
-0.022141316905617714,
0.06130332127213478,
0.05601440742611885,
-0.011232932098209858,
0.015482093207538128,
-0.04086888208985329,
-0.018499178811907768,
-0.005291919223964214,
0.06789042055606842,
0.007765087299048901,
0.0034287788439542055,
-0.01949685998260975,
0.04031594842672348,
-0.028920743614435196,
-0.015578255988657475,
-0.004125954117625952,
-0.01195414736866951,
-0.00397870596498251,
-0.02899286523461342,
0.016335532069206238,
0.049619629979133606,
0.0035399661865085363,
-0.030747823417186737,
0.005784749519079924,
-0.002624924061819911,
0.05207176133990288,
0.005667552351951599,
0.027598515152931213,
0.018727563321590424,
0.007849229499697685,
-0.0003653031890280545,
0.00309822172857821,
0.010974496603012085,
-0.016840383410453796,
-0.004735982045531273,
0.018258772790431976,
0.011299043893814087,
-0.03382501006126404,
0.010782171972095966,
-0.04036403074860573,
-0.027093663811683655,
-0.010000855661928654,
-0.0106800002977252,
-0.03702239692211151,
-0.00885292049497366,
-0.01961706206202507,
0.03493087366223335,
0.032094091176986694,
-0.025579111650586128,
-0.02020605467259884,
-0.036253102123737335,
-0.044498998671770096,
-0.05841846019029617,
0.006208463571965694,
-0.020674845203757286,
0.010571817867457867,
0.01176783349364996,
-0.02120373770594597,
-0.021961012855172157,
-0.011653641238808632,
0.024905975908041,
-0.0217807088047266,
0.009069285355508327,
0.01637159287929535,
0.0021771693136543036,
0.01555421482771635,
-0.007350388448685408,
0.022982735186815262,
0.007536702323704958,
0.019544940441846848,
-0.024136679247021675,
-0.004471536260098219,
-0.022754350677132607,
0.03757533058524132,
-0.01669614017009735,
0.011990208178758621,
0.01130505371838808,
0.013498750515282154,
0.007242206018418074,
-0.000860199797898531,
-0.032214295119047165,
-0.005261868238449097,
0.0038885537069290876,
-0.037671491503715515,
0.002633939264342189,
0.02603588066995144,
-0.05380268022418022,
-0.0026354417204856873,
0.0051747215911746025,
-0.013835318386554718,
0.007037861738353968,
-0.03519531711935997,
0.01787412539124489,
-0.00505151366814971,
-0.010397523641586304,
0.005712627898901701,
-0.02923326939344406,
0.0005657034344039857,
-0.016768261790275574,
-0.015325830318033695,
-0.009249589405953884,
0.010421564802527428,
-0.0024085594341158867,
-0.013691075146198273,
-0.02627628669142723,
-0.00427019689232111,
0.03695027530193329,
-0.026805177330970764,
0.011172831058502197,
-0.02815144695341587,
0.0060401801019907,
-0.007236195728182793,
-0.003891558852046728,
0.0027932077646255493,
-0.03194984793663025,
0.04320080950856209,
-0.00001688001248112414,
0.006310636177659035,
0.008997163735330105,
0.038416747003793716,
-0.017092809081077576,
-0.0008143725572153926,
-0.006016139406710863,
-0.007428519893437624,
-0.039089880883693695,
0.012272684834897518,
-0.03377692773938179,
-0.017176950350403786,
0.038296546787023544,
0.0037322903517633677,
-0.017525536939501762,
-0.007608823943883181,
0.023126978427171707,
0.03223833441734314,
0.012224603444337845,
-0.008053573779761791,
-0.026372447609901428,
0.03565208986401558,
0.01787412539124489,
0.007975441403687,
-0.005382070783525705,
0.03923412412405014,
-0.03680603206157684,
-0.04269596189260483,
0.006677254103124142,
0.003080191323533654,
0.0179582666605711,
0.011779854074120522,
-0.03781573474407196,
-0.020674845203757286,
-0.015193607658147812,
0.01328238658607006,
0.0017474452033638954,
-0.03449814394116402,
-0.020133933052420616,
-0.013835318386554718,
0.010758131742477417,
-0.023042837157845497,
-0.015349870547652245,
0.029978526756167412,
-0.008588475175201893,
-0.034714508801698685,
0.011948137544095516,
-0.0009052757523022592,
0.033512480556964874,
0.015109465457499027,
-0.013294406235218048,
0.004312267992645502,
0.00888898130506277,
-0.05019660294055939,
0.0341375358402729,
-0.007350388448685408,
-0.01124495267868042,
0.0024205795489251614,
-0.007680945564061403,
-0.021011412143707275,
0.018979988992214203,
0.009417872875928879,
-0.0303150936961174,
0.03002660721540451,
-0.004868204705417156,
0.060726348310709,
0.04582122713327408,
-0.039089880883693695,
0.03127671405673027,
-0.02495405822992325,
0.031300753355026245,
-0.008059583604335785,
-0.0025828531943261623,
0.0018120540771633387,
0.009177467785775661,
0.004648835398256779,
-0.006214473862200975,
0.09592166543006897,
-0.017681801691651344,
0.03733492270112038,
-0.006286595482379198,
0.010163129307329655,
0.01492916140705347,
0.023980416357517242,
0.0010179657256230712,
-0.06438050419092178,
0.028752459213137627,
-0.022814450785517693,
-0.0021771693136543036,
-0.009297670796513557,
-0.038176342844963074,
-0.015169566497206688,
0.003353652311488986,
-0.019088171422481537,
-0.01666007936000824,
-0.003006567247211933,
-0.004222115967422724,
-0.008570444770157337,
-0.01603502593934536,
0.02311495877802372,
-0.021768689155578613,
0.01728513278067112,
-0.005045503843575716,
-0.011323084123432636,
0.021420100703835487,
-0.019004030153155327,
-0.030603580176830292,
0.05769724398851395,
0.02548294886946678,
0.006007124669849873,
-0.01007898710668087,
0.0030125773046165705,
-0.0374070443212986,
0.009285650216042995,
-0.007146044168621302,
0.019088171422481537,
0.013126122765243053,
0.027213865891098976,
0.006496950052678585,
-0.017261091619729996,
-0.014171885326504707,
-0.015986943617463112,
0.010469645261764526,
-0.0054271467961370945,
-0.00982656143605709,
0.0024656555615365505,
0.021227777004241943,
0.00043235369957983494,
0.025050219148397446,
-0.005249848123639822,
-0.010169139131903648,
0.01393148023635149,
-0.005192751996219158,
-0.04632607847452164,
0.019124232232570648,
0.01395552046597004,
0.012885717675089836,
0.01299390010535717,
0.006238514557480812,
-0.01907615177333355,
-0.009778480976819992,
-0.05356227234005928,
0.017393315210938454,
-0.03435390070080757,
-0.006905638612806797,
-0.018463118001818657,
-0.005811795126646757,
0.06524596363306046,
-0.03440198302268982,
-0.0018736579222604632,
0.004318278282880783,
-0.009670298546552658,
0.010998536832630634,
0.019857468083500862,
0.021131616085767746,
0.009069285355508327,
-0.001965312287211418,
0.007777107413858175,
0.008486302569508553,
-0.006067225709557533,
0.02020605467259884,
-0.021888891234993935,
-0.05798573046922684,
-0.01907615177333355,
0.011797884479165077,
-0.006749375257641077,
-0.012753495015203953,
-0.025723354890942574,
-0.004125954117625952,
-0.006911648903042078,
-0.010986517183482647,
0.015674417838454247,
0.040339987725019455,
0.017152909189462662,
0.007518671918660402,
-0.007512662094086409,
0.034209657460451126,
-0.030387215316295624,
-0.027189826592803,
0.012669352814555168,
0.003954665269702673,
0.0031012268736958504,
0.022550005465745926,
-0.04255171865224838,
0.016395634040236473,
-0.0016392627730965614,
0.02978620119392872,
-0.015253708697855473,
0.008257918059825897,
-0.031180551275610924,
0.03452218323945999,
-0.027213865891098976,
-0.029497714713215828,
-0.00897913333028555,
0.016347551718354225,
0.00029430852737277746,
-0.001011955551803112,
-0.025218503549695015,
0.04245555400848389,
-0.0021050479263067245,
0.033296115696430206,
0.002049454255029559,
0.0056495219469070435,
0.031084390357136726,
-0.07486217468976974,
-0.014328149147331715,
-0.0187035221606493,
0.008612515404820442,
0.00866660661995411,
0.027670636773109436,
-0.031589239835739136,
-0.021732628345489502,
0.03524339944124222,
0.003329611849039793,
-0.0005439167143777013,
-0.021191716194152832,
0.014953202567994595,
-0.028127405792474747,
-0.003407743526622653,
-0.006214473862200975,
-0.009357771836221218,
-0.026372447609901428,
0.006412808317691088,
0.0020930275786668062,
-0.004952346906065941,
-0.0007114490726962686,
0.0012771525653079152,
0.044090308248996735,
-0.004639820195734501,
0.005030478350818157,
-0.004769037943333387,
0.003299561096355319,
-0.039426449686288834,
0.008840900845825672,
-0.016611997038125992,
-0.015229668468236923,
-0.03086802549660206,
0.02569931373000145,
-0.02315101958811283,
-0.029593877494335175,
0.006304625887423754,
-0.00789130013436079,
-0.022105256095528603,
0.008786809630692005,
-0.0031793585512787104,
-0.020482521504163742,
0.008059583604335785,
0.011106719262897968,
-0.004720956552773714,
-0.015013303607702255,
-0.013150162994861603,
-0.016347551718354225,
-0.016587957739830017,
-0.039546653628349304,
0.016648057848215103,
-0.010583838447928429,
-0.007680945564061403,
0.008426201529800892,
-0.005195756908506155,
-0.01887180656194687,
-0.01566239818930626,
0.0011133764637634158,
0.024809814989566803,
-0.02478577382862568,
-0.02169656753540039,
0.03401733189821243,
0.00795741192996502,
-0.003245469881221652,
0.0014341671485453844,
-0.030795903876423836,
-0.04868204891681671,
-0.010710050351917744,
-0.04070059582591057,
-0.004432470537722111,
-0.019016049802303314,
0.0021861845161765814,
-0.020590703934431076,
0.035844411700963974,
0.035051073879003525,
-0.006581091787666082,
-0.015962904319167137,
-0.012753495015203953,
-0.007356398738920689,
0.021023433655500412,
-0.015674417838454247,
0.0008654586272314191,
-0.003876533592119813,
0.024100618436932564,
0.04394606873393059,
-0.02073494717478752,
-0.002590365707874298,
0.026204165071249008,
0.009538075886666775,
0.0042341360822319984,
0.01603502593934536,
-0.015049364417791367,
-0.000520251807756722,
0.020710906013846397,
-0.01007898710668087,
0.008901001885533333,
-0.08640161901712418,
0.03935432806611061,
0.026588812470436096,
0.007025841623544693,
0.020398380234837532,
-0.048081036657094955,
0.02377607300877571,
-0.008173775859177113,
0.024341024458408356,
0.04394606873393059,
0.034305818378925323,
0.004450500942766666,
-0.03557996824383736,
-0.04678284749388695,
-0.009231559000909328,
-0.025675272569060326,
0.040796760469675064,
0.02877650037407875,
-0.008089634589850903,
0.0007670428021810949,
0.00974242016673088,
-0.00442646024748683,
0.010625909082591534,
-0.008191806264221668,
0.045412540435791016,
0.009003173559904099,
-0.027478311210870743,
-0.018559280782938004,
-0.032214295119047165,
0.012609251774847507,
0.0018541249446570873,
-0.03122863359749317,
-0.018751604482531548,
0.04276807978749275,
-0.009940754622220993,
0.009928734041750431,
-0.00023815137683413923,
0.003164333291351795,
-0.03918604552745819,
0.04425859451293945,
-0.0015761564718559384,
0.011437276378273964,
0.019304536283016205,
0.05692794546484947,
-0.011166820302605629,
-0.013005920685827732,
0.003476860001683235,
-0.04012362286448479,
0.008137715049088001,
0.0029479684308171272,
-0.014256027527153492,
-0.010896365158259869,
0.011052628047764301,
0.0023770062252879143,
-0.012525109574198723,
0.01080621313303709,
0.012789555825293064,
0.04565294459462166,
0.02944963425397873,
-0.01270541362464428,
0.009646258316934109,
-0.030843984335660934,
-0.036589667201042175,
-0.019100191071629524,
-0.04986003413796425,
0.05721643194556236,
-0.029089026153087616,
-0.07510257512331009,
0.01777796261012554,
0.0018466123146936297,
0.0015062886523082852,
0.010541766881942749,
0.03493087366223335,
0.029185188934206963,
0.015974923968315125,
-0.0670730471611023,
0.03173348307609558,
-0.006971750408411026,
-0.02985832281410694,
-0.007470590993762016,
-0.020927270874381065,
-0.006286595482379198,
0.00744655029848218,
0.011689702048897743,
-0.00400875648483634,
-0.030170850455760956,
0.01426804717630148,
-0.015578255988657475,
0.024833854287862778,
-0.008534383960068226,
-0.009075295180082321,
-0.024521328508853912,
-0.003245469881221652,
0.0012546145590022206,
-0.018499178811907768,
0.011593540199100971,
-0.0008076111553236842,
0.032262373715639114,
0.04651840403676033,
-0.0135949132964015,
0.007969431579113007,
0.017910186201334,
-0.04714345559477806,
-0.006911648903042078,
-0.004330298397690058,
0.0005829825531691313,
0.03764745220541954,
0.012717434205114841,
-0.025218503549695015,
0.0006825253367424011,
0.006115306634455919,
-0.02524254471063614,
-0.01924443431198597,
0.04976387321949005,
0.0019878502935171127,
0.043128687888383865,
-0.03394521027803421,
0.006887608207762241,
0.03882543742656708,
-0.0009263111860491335,
-0.012849656865000725,
-0.024220822378993034,
0.0013996089110150933,
-0.009964794851839542,
-0.04986003413796425,
-0.019136251881718636,
0.009249589405953884,
-0.039378367364406586,
0.017753923311829567,
0.00008578520646551624,
0.04190262407064438,
0.0010074479505419731,
0.0052768937312066555,
0.0002610649971757084,
-0.00986863300204277,
0.011906066909432411,
0.01305400114506483,
-0.01670815981924534,
0.020566662773489952,
0.011695711873471737,
-0.03719068318605423,
-0.022562026977539062,
0.023439504206180573,
-0.025795476511120796,
0.033632684499025345,
-0.0001726973132463172,
-0.011785863898694515,
-0.05024468153715134,
-0.009087315760552883,
0.009357771836221218,
0.043922025710344315,
-0.02781488001346588,
-0.006581091787666082,
0.008738728240132332,
-0.023090917617082596,
0.004468531347811222,
0.0005288913962431252,
0.026083962991833687,
0.022021114826202393,
0.0006562310154549778,
0.005099595058709383,
0.025098301470279694,
0.0466386042535305,
0.0001679079869063571,
0.0026354417204856873,
0.020398380234837532,
-0.008005492389202118,
-0.00424615666270256,
0.004702926147729158,
-0.025723354890942574,
-0.0009375801892019808,
-0.021311920136213303,
-0.010824243538081646,
0.021516263484954834,
0.016936544328927994,
0.014448351226747036,
-0.022393742576241493,
0.005424141883850098,
-0.030435295775532722,
0.0012410917552188039,
0.01566239818930626,
0.011353135108947754,
0.0038645132444798946,
-0.0214561615139246,
-0.02053060196340084,
-0.0000046601981011917815,
0.030843984335660934,
0.020915251225233078,
-0.012597231194376945,
-0.010559797286987305,
0.002970506437122822,
-0.01944877952337265,
0.015085425227880478,
-0.020350297912955284,
0.007518671918660402,
0.0248578954488039,
0.009940754622220993,
-0.023715971037745476,
-0.004811108577996492,
-0.010385503992438316,
0.01632351242005825,
-0.0018195667071267962,
0.015025324188172817,
0.0007058145711198449,
0.005502273794263601,
0.012753495015203953,
0.007963421754539013,
0.004017771687358618,
-0.0014446849236264825,
-0.03344035893678665,
-0.00775907700881362,
-0.031252674758434296,
0.03445006161928177,
-0.036878153681755066,
-0.04827335849404335,
-0.00442646024748683,
0.0002922425337601453,
0.009375802241265774,
-0.0009450928773730993,
0.018463118001818657,
-0.007981452159583569,
0.036421384662389755,
0.00007169896707637236,
-0.0023394429590553045,
0.00387953850440681,
-0.01894392818212509,
0.01907615177333355,
0.008372110314667225,
-0.03298358991742134,
-0.01143126655369997,
0.0018781655235216022,
-0.0036180978640913963,
-0.023679910227656364,
-0.01336652785539627,
0.019641103222966194,
-0.005754698999226093,
0.002718080999329686,
0.012945818714797497,
0.014544513076543808,
0.0026564772706478834,
0.016515836119651794,
-0.02468961291015148,
0.01894392818212509,
-0.0091654472053051,
-0.03127671405673027,
0.027310028672218323,
-0.0091654472053051,
0.015686437487602234,
0.012146471999585629,
0.0020749971736222506,
-0.027646595612168312,
0.004642825108021498,
0.02353566698729992,
0.007608823943883181,
0.051542870700359344,
0.004618784412741661,
-0.045965470373630524,
0.009508024901151657,
0.03747916594147682,
0.0006393275107257068,
-0.02512234076857567,
0.020085852593183517,
-0.020338278263807297,
0.01848715916275978,
-0.019845448434352875,
0.040580395609140396,
0.03396925330162048,
-0.031252674758434296,
0.008047563023865223,
0.012633292004466057,
-0.023968396708369255,
-0.003113246988505125,
0.005613461136817932,
-0.000730606378056109,
-0.004537647590041161,
0.028848621994256973,
-0.032214295119047165,
-0.015770580619573593,
0.020963331684470177,
0.02848801389336586,
0.0210354533046484,
0.03870523348450661,
-0.0035159257240593433,
0.0381523035466671,
0.03620501980185509,
-0.037959977984428406,
0.005048508755862713,
-0.032887428998947144,
-0.025290625169873238,
-0.04815315827727318,
0.0012193049769848585,
0.01293379906564951,
0.009568125940859318,
-0.013294406235218048,
-0.03048337623476982,
-0.021023433655500412,
0.011527428403496742,
0.01608310639858246,
-0.01899200864136219,
-0.0005439167143777013,
-0.001984845381230116,
0.0051687113009393215,
0.003320596646517515,
0.021263837814331055,
-0.0011809904826804996,
-0.03019488975405693,
0.020542623475193977,
0.00513265049085021,
0.013414609245955944,
-0.005367045756429434,
0.032959550619125366,
0.019605042412877083,
-0.006310636177659035,
-0.02127585932612419,
-0.020674845203757286,
-0.04632607847452164,
-0.01430410798639059,
0.0365656279027462,
-0.05111014097929001,
0.001759465434588492,
0.004059842322021723,
-0.004615779500454664,
0.010030905716121197,
-0.01574653945863247,
0.029641957953572273,
-0.018811704590916634,
-0.0017609678907319903,
0.020085852593183517,
-0.04315273091197014,
0.012092380784451962,
0.02940155379474163,
-0.0005221299943514168,
0.001520562800578773,
0.009285650216042995,
0.005318964831531048,
0.005177726503461599,
-0.016840383410453796,
-0.0182828139513731,
-0.02774275839328766,
0.003266505431383848,
-0.02711770497262478,
-0.0015686438418924809,
-0.020254136994481087,
0.008378120139241219,
0.00223877327516675,
-0.009574136696755886,
0.04538849741220474,
0.005661542061716318,
0.029209230095148087,
0.0013312436640262604,
0.015217647887766361,
0.0041800448670983315,
0.0026429544668644667,
0.01230874564498663,
0.02081908844411373,
0.014352189376950264,
0.0037743612192571163,
0.0241126399487257,
-0.039594732224941254,
-0.01114278007298708,
-0.015854721888899803,
-0.005610455758869648,
0.03644542396068573,
0.0357242114841938,
-0.006689274217933416,
-0.00882888026535511,
-0.025675272569060326,
0.0013770709047093987,
0.02502617985010147,
0.07087145000696182,
0.019148273393511772,
0.017501497641205788,
0.004690906032919884,
0.006917659193277359,
-0.029040945693850517,
-0.003657163819298148,
0.032839346677064896,
-0.042215149849653244,
-0.001900703413411975,
-0.0304112546145916,
0.019593022763729095,
-0.0001548547443235293,
0.004285222385078669,
0.009333730675280094,
-0.010914395563304424,
-0.004300247877836227,
-0.019016049802303314,
-0.007584783248603344,
-0.017008665949106216,
0.005412121769040823,
-0.0030140799935907125,
0.00989267323166132,
0.04803295433521271,
0.024353044107556343,
-0.026829218491911888,
0.011461316607892513,
-0.013919459655880928,
-0.013823297806084156,
-0.005763714201748371,
0.028415892273187637,
-0.01164162065833807,
-0.013090061955153942,
0.008913022466003895,
0.006436848547309637,
0.01307804137468338,
-0.017922205850481987,
-0.007302307523787022,
-0.02232162095606327,
-0.006472909357398748,
-0.0027736746706068516,
-0.03536360338330269,
-0.04538849741220474,
0.0419747456908226,
0.007404479663819075,
-0.014905121177434921,
0.009610197506844997,
-0.007897309958934784,
-0.008925042115151882,
0.00364514347165823,
-0.018102509900927544,
-0.007686955854296684,
0.03620501980185509,
0.01885978691279888,
-0.014881080947816372,
-0.014111784286797047,
0.0015461058355867863,
0.007801148109138012,
-0.0021786720026284456,
-0.0427200011909008,
-0.020975351333618164,
0.006037175189703703,
0.033632684499025345,
-0.019797366112470627,
-0.006611142307519913,
0.015289769507944584,
-0.024833854287862778,
0.0303631741553545,
0.011287023313343525,
-0.03137287497520447,
0.028968824073672295,
-0.026204165071249008,
-0.0000654071118333377,
-0.017213011160492897,
0.023667890578508377,
-0.04103716462850571,
0.00635270681232214,
0.000982656143605709,
-0.015085425227880478,
0.027189826592803,
0.021708587184548378,
0.013222284615039825,
-0.00826993864029646,
-0.0042882272973656654,
0.038633111864328384,
-0.0005863632541149855,
-0.03139691799879074,
-0.006370737217366695,
0.00007587788422824815,
-0.014231986366212368,
-0.01899200864136219,
0.018775643780827522,
-0.011731772683560848,
-0.0016497805481776595,
0.011437276378273964,
0.011449296958744526,
0.001368055702187121,
0.01919635385274887,
0.0002956232347059995,
0.010373483411967754,
0.016047045588493347,
-0.011028587818145752,
0.021672526374459267,
-0.013715115375816822,
0.01620330847799778,
-0.04695113003253937,
-0.007500641513615847,
-0.022261518985033035,
0.018354935571551323,
0.0006964237545616925,
0.022874552756547928,
-0.0010427574161440134,
-0.010842273943126202,
0.015794619917869568,
-0.00888898130506277,
0.00710998335853219,
0.01757361926138401,
-0.02969004027545452,
-0.003837467636913061,
0.020097872242331505,
-0.02803124487400055,
-0.01218253280967474,
0.009021203964948654,
-0.01748947612941265,
-0.038176342844963074,
0.006731344852596521,
-0.039498571306467056,
-0.01299390010535717,
0.007620844058692455,
0.0007024338701739907,
0.025675272569060326,
0.01953292079269886,
0.01836695522069931,
-0.021973034366965294,
0.004140979144722223,
-0.00632866658270359,
0.00982656143605709,
0.0010337423300370574,
-0.048874374479055405,
0.013582892715930939,
0.011407225392758846,
-0.013919459655880928,
-0.017970286309719086,
0.0026850253343582153,
-0.03514723852276802,
-0.011094698682427406,
-0.0010517726186662912,
0.00775907700881362,
0.011545458808541298,
0.010361462831497192,
0.018967969343066216,
-0.04986003413796425,
-0.004198075272142887,
0.010800202377140522,
0.033921170979738235,
-0.008570444770157337,
0.02261010743677616,
-0.018475137650966644,
-0.02036231942474842,
-0.018258772790431976,
0.007536702323704958,
-0.00580879021435976,
0.007146044168621302,
0.01932857558131218,
0.010710050351917744,
-0.010998536832630634,
0.007302307523787022,
-0.016840383410453796,
-0.012002228759229183,
0.0021967024076730013,
-0.005544344428926706,
-0.003338627051562071,
0.021143635734915733,
-0.031012268736958504,
0.017525536939501762,
-0.015325830318033695,
-0.003122262191027403,
-0.0003947903751395643,
0.020590703934431076,
-0.024004457518458366,
0.05803380906581879,
0.004483556840568781,
-0.00487121008336544,
0.013029960915446281,
-0.0021576364524662495,
-0.0052288128063082695,
0.007434530183672905,
0.00947797391563654,
0.014604615047574043,
-0.0015506134368479252,
0.0003264251572545618,
-0.008402161300182343,
-0.02361980825662613,
-0.03673391044139862,
-0.017140889540314674,
-0.007783117704093456,
-0.008630545809864998,
-0.02444920688867569,
0.011449296958744526,
-0.005352020263671875,
0.009339741431176662,
0.004101913422346115,
0.030579539015889168,
-0.02473769336938858,
0.023812133818864822,
-0.0427200011909008,
0.001789516070857644,
-0.011407225392758846,
-0.00901519414037466,
0.07284276932477951,
0.001813556533306837,
0.0033025662414729595,
-0.012272684834897518,
0.0030666685197502375,
0.0008819865179248154,
0.01333046704530716,
0.0029554811771959066,
0.02057868428528309,
0.0012786550214514136,
0.019352616742253304,
0.009363781660795212,
0.04481152445077896,
0.06861163675785065,
-0.014592594467103481,
-0.018174631521105766,
-0.003597062546759844,
0.04211898893117905,
-0.016876444220542908,
0.003080191323533654,
0.007434530183672905,
0.0011802391381934285,
-0.03156520053744316,
-0.004399414639919996,
-0.02074696682393551,
0.013186223804950714,
-0.0187035221606493,
0.00239503663033247,
0.0011201378656551242,
0.027165785431861877,
-0.0038494879845529795,
-0.02007383294403553,
0.02073494717478752,
-0.02345152571797371,
0.002219240413978696,
-0.025603150948882103,
-0.03185368701815605,
-0.005189746618270874,
0.006148362532258034,
0.03324803709983826,
0.0171649307012558,
-0.008293978869915009,
0.026925379410386086,
-0.009772470220923424,
-0.017513517290353775,
-0.011863995343446732,
-0.0366617888212204,
-0.009922724217176437,
0.02090322971343994,
-0.01720099151134491,
0.0025092291180044413,
0.010710050351917744,
0.011293033137917519,
0.03149307891726494,
-0.03291146829724312,
-0.020434441044926643,
0.006959729827940464,
0.015097444877028465,
-0.006418818142265081,
-0.03457026556134224,
-0.011665661819279194,
0.011335104703903198,
0.011545458808541298,
0.00820382684469223,
0.005556364543735981
] | 2024-07-02 | 19 | 38954005 | [
"SKOV3 cells",
"OVCAR4 cells",
"ovarian cancer cells",
"OVCAR3 cells",
"MSLN",
"MSLN-CAR T cells functions",
"MSLN-CAR T cell therapy",
"MSLN-CAR T cells",
"MSLN-CAR T cells degranulation",
"MSLN-targeting CAR T cells",
"treosulfan",
"CAR",
"low cytostatics concentration",
"+ ovarian cancer cells",
"anti-tumor killing",
"fludarabine exposure",
"effect",
"SKOV3",
"adoptive therapy",
"fludarabine",
"hypoxic conditions",
"cytostatics",
"OVCAR4",
"hypoxia",
"mitochondrial defects",
"debulking",
"Combination",
"impact",
"challenge",
"production"
] | [
"CAR T cell",
"Fludarabine",
"Mesothelin",
"Ovarian cancer",
"Treosulfan"
] | 0 | 10.1007/s00262-024-03740-3
10.1097/IGC.0000000000001118
10.4049/jimmunol.1701155
10.1158/2159-8290.CD-15-0583
10.1016/j.canlet.2018.03.032
10.1038/mt.2012.233
10.1002/stem.2715
10.1186/s40425-018-0460-5
10.1007/s40265-017-0690-8
10.1517/17425255.2013.737319
10.1182/blood-2002-11-3615
10.1007/s12185-017-2320-3
10.1080/10837450.2018.1551903
10.1136/jitc-2022-005691
10.2174/1871520611313020014
10.1186/1476-4598-10-106
10.1007/s00262-010-0920-3 | [
"El-Serafi",
"Micallef Nilsson",
"Moter",
"Duan",
"Mattsson",
"Magalhaes"
] | [
"Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. [email protected].\nBasic Medical Sciences Department, College of Medicine, Ajman University, Ajman, UAE. [email protected].",
"Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.",
"Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.",
"Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.",
"Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.\nGloria and Seymour Epstein Chair in Cell Therapy and Transplantation, Princess Margaret Cancer Centre and University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.",
"Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.\nDepartment of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden."
] | [
"38954005",
"29278600",
"29311388",
"26503962",
"29596890",
"23183537",
"29024301",
"30514386",
"30008901",
"28110394",
"26637909",
"23157726",
"12947008",
"28849374",
"30474459",
"36746513",
"22721387",
"21880146",
"20857100"
] | [] | 9.95483 | 5.91712 |
38953982 | 784 | Systemic delivery of oncolytic herpes virus using CAR-T cells enhances targeting of antitumor immuno-virotherapy. | Recent studies have indicated that combining oncolytic viruses with CAR-T cells in therapy has shown superior anti-tumor effects, representing a promising approach. Nonetheless, the localized delivery method of intratumoral injection poses challenges for treating metastatic tumors or distal tumors that are difficult to reach. To address this obstacle, we employed HSV-1-infected CAR-T cells, which systemically delivery HSV into solid tumors. The biological function of CAR-T cells remained intact after loading them with HSV for a period of three days. In both immunocompromised and immunocompetent GBM orthotopic mouse models, B7-H3 CAR-T cells effectively delivered HSV to tumor lesions, resulting in enhanced T-cell infiltration and significantly prolonged survival in mice. We also employed a bilateral subcutaneous tumor model and observed that the group receiving intratumoral virus injection exhibited a significant reduction in tumor volume on the injected side, while the group receiving intravenous infusion of CAR-T cells carrying HSV displayed suppressed tumor growth on both sides. Hence, CAR-T | [
0.02131406031548977,
0.015639537945389748,
0.04214370995759964,
0.061820004135370255,
-0.06509554386138916,
-0.06426512449979782,
0.012952213175594807,
0.012029526755213737,
-0.0020789282862097025,
-0.006995117757469416,
0.005605321377515793,
0.020575910806655884,
-0.018257660791277885,
-0.033816464245319366,
-0.008252277970314026,
-0.04894852638244629,
0.028903158381581306,
0.0076294648461043835,
-0.003953135572373867,
-0.008304179646074772,
0.0366767942905426,
0.01982622779905796,
0.008557918481528759,
-0.008298412896692753,
-0.029203031212091446,
-0.017484910786151886,
0.009059629403054714,
0.042651187628507614,
-0.0030362156685441732,
-0.03750720992684364,
-0.011533582583069801,
-0.0214293971657753,
-0.020587444305419922,
-0.03771481662988663,
-0.021094921976327896,
0.06855561584234238,
0.06301949918270111,
0.01668909378349781,
-0.00946907140314579,
0.016896698623895645,
0.02291722781956196,
0.015455001033842564,
0.015316598117351532,
0.106570303440094,
-0.03842989727854729,
0.028072740882635117,
-0.07270770519971848,
-0.09143824130296707,
-0.030448658391833305,
0.007087386678904295,
0.0007424743962474167,
0.005017108283936977,
-0.012444735504686832,
0.025050941854715347,
-0.015835609287023544,
0.011222176253795624,
-0.009774710983037949,
0.005833109375089407,
-0.008517551235854626,
0.01302141509950161,
0.003393756691366434,
-0.021463997662067413,
0.03047172538936138,
-0.02385144867002964,
-0.01091653574258089,
-0.014809120446443558,
-0.05000961571931839,
-0.030979203060269356,
-0.005040175747126341,
0.008805890567600727,
-0.013355888426303864,
-0.016239283606410027,
0.01893814280629158,
-0.007479528430849314,
0.03759947791695595,
0.021141057834029198,
-0.007173888385295868,
0.005285264458507299,
0.020160702988505363,
-0.033885665237903595,
0.02555841952562332,
-0.02941063605248928,
0.014739918522536755,
-0.03584637492895126,
-0.04013686627149582,
-0.0041866903193295,
0.01284841075539589,
-0.022236747667193413,
-0.026065897196531296,
0.009647841565310955,
-0.005256430245935917,
0.048810120671987534,
-0.017853986471891403,
0.017542578279972076,
-0.02260582149028778,
0.0033908733166754246,
-0.008211910724639893,
-0.08807043731212616,
0.036192383617162704,
0.009572873823344707,
0.052224062383174896,
-0.02396678552031517,
0.001843931502662599,
-0.02645803801715374,
0.058913540095090866,
0.027726732194423676,
-0.046549540013074875,
0.04267425462603569,
0.04599592834711075,
0.0046018995344638824,
0.121425561606884,
-0.023401638492941856,
0.020252970978617668,
0.026919381693005562,
-0.006476106587797403,
-0.02396678552031517,
-0.00021805679716635495,
-0.0387067049741745,
-0.013298220932483673,
-0.0051526278257369995,
-0.01893814280629158,
-0.002864653477445245,
-0.011210642755031586,
-0.042235977947711945,
-0.0029900812078267336,
-0.01322901900857687,
0.06472646445035934,
-0.03863750025629997,
-0.011798854917287827,
-0.05462304875254631,
-0.010766599327325821,
-0.00846564956009388,
0.030794665217399597,
-0.002998731564730406,
-0.06837107986211777,
0.002315366640686989,
-0.026711776852607727,
-0.004019453655928373,
-0.02521241083741188,
0.04142862930893898,
-0.0013436623848974705,
-0.04156703129410744,
-0.0016190266469493508,
-0.009030795656144619,
-0.06338857114315033,
-0.031625084578990936,
-0.01691976562142372,
0.030402524396777153,
-0.004062704276293516,
0.005697589833289385,
-0.016354620456695557,
0.03088693507015705,
0.054115571081638336,
-0.010039983317255974,
-0.019145747646689415,
-0.03538503125309944,
-0.014197840355336666,
0.07386106252670288,
-0.031163740903139114,
-0.07164661586284637,
-0.0011447081342339516,
-0.015247396193444729,
0.011176041327416897,
-0.0164584219455719,
-0.006948983762413263,
0.020103033632040024,
-0.004206874407827854,
0.02657337486743927,
-0.0465264730155468,
-0.02101418748497963,
-0.01245626900345087,
-0.04645727202296257,
-0.049502138048410416,
-0.013690362684428692,
-0.055730272084474564,
-0.0029439469799399376,
0.020818116143345833,
0.001872765482403338,
0.015189728699624538,
-0.0007334637921303511,
-0.00232978374697268,
0.040805816650390625,
0.051162973046302795,
0.009653608314692974,
-0.026619508862495422,
0.040875017642974854,
0.011049171909689903,
0.03741494193673134,
-0.045949794352054596,
-0.007963938638567924,
-0.0026671409141272306,
-0.04765676334500313,
0.05273154005408287,
0.022582754492759705,
0.01332128793001175,
-0.0028603284154087305,
0.01485525444149971,
0.013817232102155685,
-0.01379416510462761,
-0.024958672001957893,
0.04774903133511543,
-0.001917458139359951,
-0.045557651668787,
-0.02638883702456951,
-0.06029757112264633,
-0.050101883709430695,
-0.010991504415869713,
0.047426093369722366,
0.00985544640570879,
-0.0039300681091845036,
0.013044482097029686,
-0.005129560828208923,
-0.011406713165342808,
0.015674138441681862,
-0.025650687515735626,
-0.04274345561861992,
-0.017900120466947556,
0.04751836135983467,
0.02166006900370121,
0.015028257854282856,
-0.014543848112225533,
-0.024012919515371323,
-0.040921151638031006,
0.00399638619273901,
-0.04089808464050293,
0.02172926999628544,
0.008782823570072651,
-0.0428587943315506,
-0.0006664248066954315,
-0.027795935049653053,
0.010593595914542675,
-0.01640075445175171,
0.032224830240011215,
-0.056791361421346664,
-0.030679330229759216,
0.010339857079088688,
0.045903660356998444,
-0.010293722152709961,
0.033009111881256104,
-0.01763484813272953,
0.017969321459531784,
0.027311524376273155,
0.05250086635351181,
-0.03176348656415939,
0.004627849906682968,
-0.02846488170325756,
-0.008557918481528759,
-0.05522279441356659,
-0.0206566471606493,
0.00027230067644268274,
-0.04272038862109184,
-0.028857024386525154,
-0.015881743282079697,
-0.018799738958477974,
0.010668563656508923,
0.011124140582978725,
-0.018684403970837593,
-0.015132060274481773,
0.00543231749907136,
-0.05190112069249153,
0.019803160801529884,
-0.027842069044709206,
-0.023459307849407196,
-0.04484257102012634,
-0.05651455372571945,
-0.006850948091596365,
-0.0022980663925409317,
0.014416978694498539,
0.028741687536239624,
-0.012041060253977776,
0.015281996689736843,
0.0026008228305727243,
0.05614548176527023,
-0.026665642857551575,
-0.02733459137380123,
-0.010789666324853897,
-0.009244166314601898,
0.03413940593600273,
-0.01969935931265354,
0.010639729909598827,
0.0069259162992239,
0.023713046684861183,
-0.005181462038308382,
-0.022997964173555374,
-0.012202530167996883,
0.006718311924487352,
-0.04368920996785164,
0.007519895676523447,
-0.002992964582517743,
-0.03723040595650673,
0.018430665135383606,
0.014959056861698627,
-0.013840299099683762,
-0.021625466644763947,
0.008361847139894962,
0.032640039920806885,
-0.01447464618831873,
0.010334090329706669,
-0.0025244129355996847,
-0.002171196974813938,
-0.034300874918699265,
0.02472800202667713,
0.002404751954600215,
0.0016536273760721087,
-0.012029526755213737,
0.015016724355518818,
-0.016435354948043823,
0.015397332608699799,
0.00630310270935297,
0.027449926361441612,
0.008085041306912899,
-0.04089808464050293,
0.023332437500357628,
0.04774903133511543,
0.012329399585723877,
0.035015955567359924,
0.00817154347896576,
-0.055315062403678894,
-0.01379416510462761,
-0.04253585264086723,
-0.010345623828470707,
0.008338780142366886,
-0.04451962932944298,
0.0025258546229451895,
-0.0018597901798784733,
-0.0402522049844265,
0.02313636615872383,
-0.00976894423365593,
0.002143804682418704,
-0.010668563656508923,
0.036907464265823364,
0.00442312890663743,
0.03999846428632736,
-0.02362077683210373,
0.005602437537163496,
-0.02592749334871769,
-0.05245473235845566,
-0.04094421863555908,
0.00009226865950040519,
-0.016020147129893303,
-0.022651955485343933,
0.022997964173555374,
-0.012087194249033928,
0.04156703129410744,
-0.02698858268558979,
0.017657915130257607,
0.022536620497703552,
0.03231709823012352,
0.005256430245935917,
0.005158395040780306,
-0.002151013119146228,
-0.013678829185664654,
0.038568299263715744,
0.04207450896501541,
-0.01239860150963068,
0.020691247656941414,
-0.01775018312036991,
-0.009059629403054714,
0.018719004467129707,
-0.005322748329490423,
0.021913807839155197,
0.02309023216366768,
-0.021463997662067413,
0.026112031191587448,
0.07224636524915695,
0.04936373233795166,
-0.04463496431708336,
0.031140673905611038,
-0.02864941954612732,
-0.001023605465888977,
-0.02302103117108345,
-0.008777056820690632,
0.010466726496815681,
0.02456653118133545,
-0.003927184734493494,
0.026827113702893257,
0.020748915150761604,
0.03591557592153549,
0.019065011292696,
0.026365770027041435,
0.07372266054153442,
-0.019722426310181618,
-0.052224062383174896,
-0.04445042833685875,
-0.028833957388997078,
-0.021094921976327896,
0.038983508944511414,
-0.0010538811329752207,
-0.07164661586284637,
0.00923839956521988,
0.0005305447848513722,
0.01733497530221939,
0.022951830178499222,
0.005164161790162325,
-0.03953712061047554,
0.07898197323083878,
-0.0006264176918193698,
0.04403521865606308,
0.0022548153065145016,
0.017081236466765404,
0.007271924056112766,
-0.06329630315303802,
-0.032409366220235825,
-0.03829149529337883,
0.01918034814298153,
-0.02356310933828354,
0.03593864291906357,
0.003563876962289214,
0.0064991735853254795,
0.00831571314483881,
-0.009676676243543625,
-0.008667487651109695,
0.018603669479489326,
-0.0066491104662418365,
0.013921034522354603,
0.0008542059804312885,
-0.023989852517843246,
0.04396601766347885,
0.003953135572373867,
0.027196187525987625,
0.02846488170325756,
-0.027265388518571854,
-0.002364384476095438,
-0.02917996421456337,
-0.013944101519882679,
-0.020391374826431274,
0.03250163421034813,
0.02941063605248928,
0.02161393314599991,
-0.05203952640295029,
-0.028095807880163193,
0.04830264300107956,
-0.030287187546491623,
-0.0027565262280404568,
-0.004636500030755997,
0.04468109831213951,
-0.021983008831739426,
0.007433393970131874,
-0.05485371872782707,
0.048394910991191864,
-0.010605129413306713,
-0.016965899616479874,
-0.012836877256631851,
-0.050286419689655304,
0.04387374967336655,
-0.00329283787868917,
0.01207566075026989,
0.057437241077423096,
-0.022121410816907883,
-0.007225789595395327,
0.004209757782518864,
-0.01239860150963068,
-0.003180385334417224,
-0.024543464183807373,
-0.01547806803137064,
0.005051709245890379,
0.03496982157230377,
-0.09651301801204681,
0.01847679913043976,
0.011568183079361916,
0.0073122913017869,
-0.01859213598072529,
-0.005637038499116898,
-0.04977894201874733,
0.005120910704135895,
0.05983622744679451,
0.031348276883363724,
-0.03379339724779129,
-0.0003124880022369325,
-0.01640075445175171,
0.012029526755213737,
0.001776171731762588,
0.0005795625038444996,
0.012121795676648617,
-0.030587060377001762,
0.017415709793567657,
-0.007790935225784779,
-0.02112952247262001,
0.011793088167905807,
0.018453732132911682,
-0.0076294648461043835,
-0.019364885985851288,
-0.013540426269173622,
-0.00961324106901884,
0.04002153128385544,
0.018315330147743225,
0.007473761681467295,
-0.026065897196531296,
0.04198224097490311,
0.03506208956241608,
-0.0397677943110466,
-0.001900157774798572,
0.019157281145453453,
-0.00971127673983574,
-0.013990235514938831,
0.019088080152869225,
-0.003217869671061635,
0.0028487949166446924,
-0.02309023216366768,
0.022398216649889946,
0.011349045671522617,
0.023805314674973488,
0.00040908175287768245,
-0.014186306856572628,
0.023424705490469933,
0.02804967388510704,
0.005495752207934856,
0.05111683905124664,
0.0030131484381854534,
0.0031140672508627176,
-0.019041944295167923,
-0.008309946395456791,
0.0022591406013816595,
0.012940679676830769,
-0.02041444182395935,
-0.02366691082715988,
-0.04917919635772705,
0.006453039590269327,
-0.0055072857066988945,
-0.01839606463909149,
-0.04479643329977989,
-0.011723887175321579,
-0.012260198593139648,
-0.020195303484797478,
0.020818116143345833,
-0.017242705449461937,
-0.01703510247170925,
-0.03896044194698334,
-0.017242705449461937,
-0.03656145557761192,
-0.01580100879073143,
-0.03942178562283516,
0.005928261671215296,
-0.008154243230819702,
0.001515224459581077,
-0.014301642775535583,
-0.06094345077872276,
0.023217102512717247,
0.0022836492862552404,
0.008061974309384823,
0.00840798206627369,
-0.0038089656736701727,
0.022282881662249565,
0.013771098107099533,
0.022571220993995667,
0.01634308695793152,
0.03360886126756668,
-0.03969858959317207,
0.01869593746960163,
-0.012237131595611572,
0.011510515585541725,
-0.027196187525987625,
0.016054747626185417,
0.008736688643693924,
0.02977970987558365,
-0.015120526775717735,
-0.012329399585723877,
-0.027772866189479828,
-0.031025337055325508,
-0.006032063625752926,
-0.002867537084966898,
0.004642266780138016,
0.006626043003052473,
-0.025604553520679474,
0.016527624800801277,
0.0035667603369802237,
0.024935605004429817,
-0.022582754492759705,
-0.03877590596675873,
0.030702397227287292,
-0.02107185497879982,
0.0021236208267509937,
0.03144054487347603,
-0.026250433176755905,
0.018719004467129707,
-0.0058417594991624355,
-0.022006075829267502,
-0.01138941291719675,
-0.008056207560002804,
0.013517359271645546,
-0.031140673905611038,
-0.03769174963235855,
-0.013528892770409584,
0.03930645063519478,
0.00534004857763648,
0.03266310691833496,
-0.04322786629199982,
0.009330668486654758,
-0.011879590339958668,
-0.012064127251505852,
0.011204875074326992,
-0.011204875074326992,
0.03734574094414711,
-0.01453231368213892,
-0.036192383617162704,
0.008263812400400639,
0.01691976562142372,
-0.015512668527662754,
-0.046203531324863434,
-0.016850564628839493,
-0.028141941875219345,
-0.029018493369221687,
0.01453231368213892,
-0.03164815157651901,
-0.016504555940628052,
0.03386259824037552,
-0.0035955943167209625,
-0.01364422868937254,
0.011527815833687782,
-0.017427243292331696,
0.060528241097927094,
0.01249087043106556,
-0.014105571433901787,
-0.02781900204718113,
0.030794665217399597,
0.00009920683078235015,
-0.016170082613825798,
-0.023989852517843246,
0.03261697292327881,
-0.03183268755674362,
-0.023044098168611526,
0.001828072825446725,
0.007606397848576307,
-0.003863750258460641,
-0.0008837607456371188,
-0.014140171930193901,
-0.006222367752343416,
-0.019364885985851288,
0.0027868018951267004,
0.006205067504197359,
0.0027868018951267004,
-0.02237514965236187,
-0.010409058071672916,
0.0029453886672854424,
0.01935335248708725,
-0.036607589572668076,
-0.01077236607670784,
0.013009881600737572,
0.016320019960403442,
-0.00046206414117477834,
-0.03833762928843498,
0.05143977701663971,
0.008217677474021912,
-0.026204299181699753,
0.029733575880527496,
0.008500250056385994,
-0.01470531802624464,
0.021164124831557274,
-0.012202530167996883,
-0.011372112669050694,
-0.021521665155887604,
-0.044658031314611435,
0.02366691082715988,
0.00010028810356743634,
0.005974395666271448,
-0.024174388498067856,
0.009815079160034657,
-0.007168121635913849,
0.04147476330399513,
0.047795165330171585,
-0.003938718698918819,
0.018453732132911682,
-0.016712160781025887,
-0.009659375064074993,
-0.01585867628455162,
-0.017185037955641747,
-0.002205797703936696,
-0.004059820901602507,
0.009890046902000904,
0.01408250443637371,
0.07833608984947205,
0.006458806339651346,
0.0543462410569191,
-0.019860830157995224,
0.007865902967751026,
0.02763446420431137,
0.007196955382823944,
-0.0240359865128994,
-0.016839031130075455,
0.0020630694925785065,
-0.02160239964723587,
-0.008921226486563683,
-0.03118680790066719,
-0.048625584691762924,
0.022236747667193413,
0.012237131595611572,
-0.007179655134677887,
-0.02971050888299942,
-0.0016853447305038571,
-0.013632694259285927,
0.0029958481900393963,
-0.033285919576883316,
-0.02309023216366768,
-0.02532774768769741,
0.00624543521553278,
0.01192572433501482,
0.007923571392893791,
-0.012214063666760921,
-0.017773250117897987,
0.007104686927050352,
0.02698858268558979,
0.007133520673960447,
0.037022799253463745,
-0.035707972943782806,
0.018257660791277885,
-0.03575410693883896,
0.0014503480633720756,
-0.015455001033842564,
0.018372997641563416,
0.018130792304873466,
-0.01698896661400795,
0.02230594865977764,
-0.0026339818723499775,
-0.02846488170325756,
-0.0025373881217092276,
0.003523509483784437,
-0.009111530147492886,
0.007150821387767792,
0.018903542309999466,
0.00059578160289675,
-0.022940296679735184,
0.00003993953578174114,
-0.007917804643511772,
-0.005210295785218477,
0.0361001119017601,
0.04936373233795166,
-0.07118526846170425,
0.025719888508319855,
-0.009249933063983917,
-0.015466534532606602,
0.0051785786636173725,
-0.00534293195232749,
-0.027611397206783295,
-0.013863366097211838,
-0.02408212050795555,
0.040921151638031006,
-0.041405562311410904,
-0.02936450205743313,
-0.026181232184171677,
-0.0068855490535497665,
0.03639998659491539,
-0.010830034501850605,
-0.026411904022097588,
0.013817232102155685,
-0.013909501023590565,
0.03259390592575073,
0.033170584589242935,
-0.008823190815746784,
0.011706585995852947,
-0.018199993297457695,
0.0038320329040288925,
0.0076294648461043835,
-0.032409366220235825,
-0.01721963845193386,
-0.007404560223221779,
0.003128484357148409,
-0.007825535722076893,
0.011522049084305763,
-0.016585292294621468,
-0.010074584744870663,
-0.037092000246047974,
0.0020962285343557596,
-0.010178386233747005,
0.0029958481900393963,
0.0005954211810603738,
-0.017300374805927277,
-0.005559186916798353,
0.013771098107099533,
-0.04691861569881439,
0.01839606463909149,
-0.008892391808331013,
-0.04251278564333916,
-0.003907001111656427,
-0.02408212050795555,
0.0017300373874604702,
0.022179080173373222,
-0.024843337014317513,
0.01870747096836567,
0.0022432818077504635,
0.026135098189115524,
-0.017900120466947556,
0.01740417629480362,
0.003791665192693472,
-0.0011223617475479841,
-0.01130291074514389,
0.0072142560966312885,
0.0049306065775454044,
0.025789091363549232,
0.0002915833902079612,
-0.026319636031985283,
0.00040151283610612154,
0.0028934874571859837,
0.0056197382509708405,
0.03499288856983185,
-0.012271732091903687,
0.022340549156069756,
0.04747222736477852,
-0.08664027601480484,
-0.04502710700035095,
0.022398216649889946,
-0.009503671899437904,
0.0032495867926627398,
0.02472800202667713,
-0.026088964194059372,
-0.03644612058997154,
0.011729653924703598,
0.0037541810888797045,
-0.009578640572726727,
-0.04209757596254349,
0.001878532231785357,
0.0012780651450157166,
0.0112452432513237,
-0.009486371651291847,
-0.012214063666760921,
-0.07293837517499924,
-0.014186306856572628,
0.013621160760521889,
-0.01139517966657877,
0.005190112162381411,
-0.019214948639273643,
0.01663142628967762,
0.0016983200330287218,
0.007421860471367836,
-0.01863826997578144,
-0.018384531140327454,
-0.03001038171350956,
-0.024589598178863525,
-0.007485295180231333,
0.017254238948225975,
-0.0298258438706398,
0.03485448658466339,
-0.02237514965236187,
-0.055315062403678894,
0.03614624962210655,
-0.010276421904563904,
0.009970782324671745,
0.02687324769794941,
-0.000671470770612359,
-0.029848912730813026,
0.0018871824722737074,
-0.0055072857066988945,
-0.002987197833135724,
-0.007744800765067339,
0.011360579170286655,
0.006193534005433321,
0.006037830375134945,
-0.021094921976327896,
0.031348276883363724,
-0.051947254687547684,
-0.03806082159280777,
0.016320019960403442,
-0.004368344321846962,
-0.035961709916591644,
0.02302103117108345,
-0.001298248884268105,
-0.0006451598019339144,
-0.005527469329535961,
-0.008805890567600727,
0.005484218709170818,
0.0038176157977432013,
-0.0010654147481545806,
-0.015489601530134678,
-0.008246511220932007,
-0.01934181898832321,
0.020437508821487427,
-0.0345546118915081,
0.017554113641381264,
-0.0156856719404459,
0.017138903960585594,
-0.01360962726175785,
0.027657531201839447,
0.012202530167996883,
-0.002138037933036685,
-0.004633616656064987,
-0.012121795676648617,
-0.0164584219455719,
0.02994118072092533,
-0.00840221531689167,
-0.016885165125131607,
-0.005833109375089407,
0.01216792967170477,
-0.008529084734618664,
0.004149206448346376,
0.00923263281583786,
-0.013897967524826527,
-0.0032553537748754025,
-0.027680598199367523,
0.01823459379374981,
-0.04419668763875961,
-0.023170966655015945,
0.040505941957235336,
0.0329168438911438,
-0.013724963180720806,
-0.030794665217399597,
0.0063088699243962765,
0.004353927448391914,
-0.021279459819197655,
0.04581138864159584,
-0.038314562290906906,
0.00947483815252781,
-0.03197108954191208,
-0.03923724964261055,
0.015420399606227875,
0.03584637492895126,
0.007773634511977434,
0.01375956367701292,
-0.031578950583934784,
0.01912268064916134,
0.031048404052853584,
0.012317866086959839,
-0.012940679676830769,
-0.007168121635913849,
0.025258546695113182,
0.033055249601602554,
-0.012663873843848705,
0.00999961607158184,
-0.0266425758600235,
0.0649571344256401,
0.03024105355143547,
0.02255968749523163,
-0.007508362177759409,
-0.004800853785127401,
-0.007773634511977434,
-0.003898350987583399,
0.013494291342794895,
-0.054300107061862946,
0.012006459757685661,
-0.02758833020925522,
0.033009111881256104,
0.00249990401789546,
-0.0064934068359434605,
-0.05522279441356659,
0.048441048711538315,
-0.021925341337919235,
0.034231673926115036,
0.011274076998233795,
0.027449926361441612,
0.024405060335993767,
-0.015247396193444729,
-0.0033245552331209183,
-0.012364001013338566,
-0.005951328668743372,
0.001714178710244596,
-0.022409750148653984,
0.004088655114173889,
0.0000821317225927487,
-0.019630158320069313,
-0.013044482097029686,
0.017507977783679962,
0.020252970978617668,
0.045073240995407104,
0.04308946430683136,
0.03847603127360344,
0.024958672001957893,
-0.026550307869911194,
-0.01547806803137064,
0.016619892790913582,
-0.031509749591350555,
0.05457691475749016,
-0.03289377689361572,
-0.043781477957963943,
0.02059897780418396,
-0.014359310269355774,
-0.007508362177759409,
0.022271348163485527,
0.01899581030011177,
0.050563227385282516,
0.0016320019494742155,
-0.03427780792117119,
0.029133830219507217,
0.007912037894129753,
0.002636865247040987,
0.021556265652179718,
-0.0020789282862097025,
0.01138941291719675,
0.015835609287023544,
0.012767676264047623,
-0.0030131484381854534,
-0.033009111881256104,
0.0023225753102451563,
-0.022352082654833794,
0.020818116143345833,
-0.04599592834711075,
-0.02581215836107731,
-0.00976317748427391,
0.019099613651633263,
-0.006182000506669283,
-0.041705433279275894,
-0.03679212927818298,
-0.0026786746457219124,
0.04165929928421974,
0.02214447781443596,
-0.005559186916798353,
-0.02562762051820755,
0.012640806846320629,
-0.04112875461578369,
-0.02899542637169361,
-0.02325170300900936,
0.015051325783133507,
0.022455886006355286,
-0.04451962932944298,
-0.02911076322197914,
0.026112031191587448,
0.008517551235854626,
-0.023159433156251907,
-0.03386259824037552,
0.017069702968001366,
0.010899235494434834,
0.0764445886015892,
-0.027772866189479828,
0.032824575901031494,
-0.015097459778189659,
0.023009497672319412,
0.006395371630787849,
-0.009740110486745834,
-0.013955635018646717,
-0.020806582644581795,
-0.01853446662425995,
-0.015305064618587494,
0.007098920177668333,
-0.006476106587797403,
0.0021985892672091722,
0.005106493830680847,
0.03310138359665871,
0.0191111471503973,
-0.006395371630787849,
0.019618624821305275,
-0.010616662912070751,
0.014682251028716564,
0.020287571474909782,
-0.0013876341981813312,
-0.010841568000614643,
0.006752912420779467,
-0.00956134032458067,
-0.040459807962179184,
-0.008926993235945702,
-0.028280343860387802,
0.03584637492895126,
0.010507093742489815,
0.013090616092085838,
-0.06491100043058395,
-0.0023009497672319412,
-0.008500250056385994,
0.04940986633300781,
-0.04982507601380348,
0.01585867628455162,
0.022502020001411438,
0.0067356121726334095,
-0.00046638926141895354,
0.016423821449279785,
0.03787628561258316,
0.025004807859659195,
0.022006075829267502,
0.02178693749010563,
0.030563993379473686,
0.002381684724241495,
0.013632694259285927,
0.0037743649445474148,
-0.015674138441681862,
0.007381492760032415,
-0.02911076322197914,
0.014290109276771545,
-0.006712545175105333,
0.0013068991247564554,
-0.01476298552006483,
0.0008008631411939859,
0.03164815157651901,
0.04248971864581108,
0.010587829165160656,
-0.012283265590667725,
0.0021928222849965096,
-0.011233709752559662,
-0.014036370441317558,
0.01776171661913395,
0.0345546118915081,
0.011354812420904636,
0.005123794078826904,
-0.005564953666180372,
-0.008252277970314026,
-0.007721733767539263,
0.0038781671319156885,
0.023044098168611526,
0.0022649073507636786,
-0.012836877256631851,
-0.03836069628596306,
0.009515205398201942,
-0.03220176324248314,
-0.01224866509437561,
-0.0011108281323686242,
0.0029439469799399376,
0.007566030137240887,
-0.025235479697585106,
-0.00991311389952898,
0.011435546912252903,
-0.03164815157651901,
-0.02385144867002964,
0.007225789595395327,
0.00961324106901884,
0.022225214168429375,
-0.019457153975963593,
-0.014036370441317558,
0.029387569054961205,
-0.04940986633300781,
-0.0075429631397128105,
-0.028787821531295776,
0.03174041956663132,
-0.01746184378862381,
-0.018511399626731873,
0.018246127292513847,
0.01375956367701292,
-0.013263620436191559,
-0.004218407906591892,
0.045788321644067764,
0.02011456899344921,
-0.004584599286317825,
0.00046458712313324213,
0.006533774547278881,
-0.018569067120552063,
0.003327438607811928,
-0.0018799739191308618,
-0.008240744471549988,
0.002998731564730406,
-0.015293530188500881,
0.027057785540819168,
0.006533774547278881,
-0.014117104932665825,
-0.034762218594551086,
0.038199227303266525,
-0.019076544791460037,
0.014486179687082767,
-0.021198725327849388,
-0.019607091322541237,
0.012467802502214909,
-0.003359155962243676,
0.01400176901370287,
0.007185421884059906,
0.006608742754906416,
-0.0004519722715485841,
0.02438199333846569,
0.02201760932803154,
0.007387259509414434,
0.0022360733710229397,
-0.0012405809247866273,
-0.01680443063378334,
0.015362732112407684,
0.0012427435722202063,
-0.017185037955641747,
0.053654227405786514,
-0.024358926340937614,
-0.04857945069670677,
0.0361001119017601,
0.03402406722307205,
0.001905924524180591,
-0.010397524572908878,
-0.01811925880610943,
0.0002622088068164885,
0.012883012183010578,
0.004270309116691351,
0.014359310269355774,
0.02479720301926136,
-0.02350544184446335,
0.028211142867803574,
0.0020962285343557596,
-0.002151013119146228,
-0.00016768748173490167,
-0.006372304633259773,
0.007450694218277931,
0.01183345541357994,
0.007185421884059906,
-0.04964054003357887,
-0.023574642837047577,
-0.004624966531991959,
0.015455001033842564,
0.05711429938673973,
0.03432394191622734,
-0.008033140562474728,
0.014255507849156857,
-0.005198762286454439,
-0.02100265398621559,
0.012502403929829597,
-0.011320210993289948,
-0.010605129413306713,
-0.03877590596675873,
-0.06832494586706161,
-0.026942448690533638,
0.024820270016789436,
-0.004708585329353809,
-0.0029107879381626844,
-0.006135866045951843,
-0.012202530167996883,
0.01100880466401577,
0.0019261082634329796,
-0.014959056861698627,
0.0018655570456758142,
0.0042789592407643795,
-0.004800853785127401,
-0.02160239964723587,
-0.013713429681956768,
-0.010138018988072872,
0.0045211645774543285,
-0.004302026238292456,
0.0344623439013958,
0.0022317483089864254,
0.022801892831921577,
-0.010432125069200993,
0.004636500030755997,
-0.014347776770591736,
-0.01776171661913395,
-0.007364192511886358,
-0.049086928367614746,
-0.005031525623053312,
-0.03217869624495506,
0.008604052476584911,
-0.012317866086959839,
-0.022213680669665337,
-0.008258044719696045,
-0.032755374908447266,
0.019099613651633263,
0.006055131088942289,
0.029549038037657738,
-0.00021138894953764975,
-0.029226098209619522,
0.006660643965005875,
0.011412479914724827,
0.0058359927497804165,
-0.036492254585027695,
0.04825650900602341,
-0.0044836802408099174,
0.030494792386889458,
-0.004815270658582449,
-0.019076544791460037,
-0.04940986633300781,
-0.00004216966044623405,
0.000820326036773622,
0.001288877916522324,
-0.018845874816179276,
0.023424705490469933,
-0.0028747455216944218,
-0.009076929651200771,
0.03674599528312683,
-0.0016002845950424671,
0.02947983704507351,
-0.005250663496553898,
0.0005139652639627457,
-0.009572873823344707,
-0.0006948983645997941,
0.0034860253799706697,
0.009549806825816631,
0.03178655356168747,
-0.009838146157562733,
0.011487448588013649,
-0.02208681032061577,
0.015708738937973976,
-0.06306563317775726,
-0.002489812206476927,
0.022455886006355286,
0.00716235488653183,
-0.03787628561258316,
-0.018084658309817314,
-0.01479758694767952,
0.03404713422060013,
0.009151897393167019,
0.017554113641381264,
-0.0050920769572257996,
0.011798854917287827,
-0.01133751217275858,
0.0009976548608392477,
-0.009163431823253632,
0.008546384982764721,
0.011343278922140598,
0.0010538811329752207,
0.01886894181370735,
-0.03771481662988663,
0.04283572733402252,
-0.0019116912735626101,
0.03522356227040291,
-0.035131294280290604,
-0.03653838858008385,
0.0031775019597262144,
0.018730537965893745,
-0.005688939709216356,
-0.005464034620672464,
0.04558071866631508,
-0.01500519085675478,
-0.02396678552031517,
0.032939910888671875,
0.016654493287205696,
-0.007790935225784779,
-0.027126986533403397,
-0.029733575880527496,
-0.0012859944254159927,
-0.0183383971452713,
-0.013494291342794895,
0.013863366097211838,
0.011216409504413605,
-0.011729653924703598,
-0.00938256923109293,
-0.007912037894129753,
0.017473377287387848,
0.010016916319727898,
-0.0021582215558737516,
0.00016624577983748168,
0.026319636031985283,
-0.036423053592443466,
-0.050517093390226364,
0.03360886126756668,
0.00581292575225234,
-0.028072740882635117,
-0.00485563836991787,
-0.011660452000796795,
0.014878321439027786,
0.04475029930472374,
-0.055730272084474564,
0.015374265611171722,
0.028072740882635117,
0.0246126651763916,
-0.004140556324273348,
-0.0032553537748754025,
0.008113875053822994,
0.02172926999628544,
-0.011331744492053986,
-0.01207566075026989,
0.0012996905716136098,
0.013817232102155685,
0.04253585264086723,
-0.006470339838415384,
-0.010305255651473999,
0.03176348656415939,
-0.008604052476584911,
-0.018776671960949898,
0.009630541317164898,
-0.02710391953587532,
0.013159818015992641,
-0.025120142847299576,
-0.004454846493899822,
-0.03351658955216408,
-0.01580100879073143,
-0.022455886006355286,
0.015455001033842564,
0.033585794270038605,
0.00961900781840086,
0.011147207580506802,
0.015547269023954868,
0.03409327194094658,
-0.017784783616662025,
-0.025489218533039093,
0.028095807880163193,
0.03072546422481537,
-0.03118680790066719,
-0.001776171731762588,
-0.0025373881217092276,
0.0006350678741000593,
-0.016077814623713493,
0.02551228553056717,
-0.0008686229703016579,
-0.03522356227040291,
0.001097132102586329,
0.01769251562654972,
-0.0031717352103441954,
0.021198725327849388,
0.01100880466401577,
0.0032322865445166826,
0.015316598117351532,
-0.001985217910259962,
-0.003416823921725154,
0.032040294259786606,
-0.005694706458598375,
-0.038268428295850754,
-0.00711622042581439,
0.0008693438139744103,
0.01916881464421749,
-0.023574642837047577,
0.008263812400400639,
-0.00018579880998004228,
0.0013934009475633502,
0.0036244282964617014,
0.027034718543291092,
-0.021637000143527985,
0.0073122913017869,
-0.00221300614066422,
0.022213680669665337,
-0.0266425758600235,
-0.012237131595611572,
-0.05065549537539482,
-0.0002807706478051841,
0.03333205357193947,
-0.009192265570163727,
-0.03988312929868698,
-0.0006977817392908037,
0.0076294648461043835,
0.00030149504891596735,
0.03425474092364311,
0.0048498716205358505,
-0.016839031130075455,
0.009203799068927765,
-0.028072740882635117,
-0.006626043003052473,
-0.015143593773245811,
0.04793357104063034,
-0.04597286134958267,
-0.03769174963235855,
0.0011951675405725837,
0.0015527085633948445,
0.002913671312853694,
-0.015731805935502052,
-0.0035004422534257174,
-0.014520780183374882,
-0.027795935049653053,
0.008828957565128803,
0.022513553500175476,
-0.025650687515735626,
0.013563493266701698,
0.022755758836865425,
-0.03859136626124382,
0.016539158299565315,
-0.023874515667557716,
0.006597209256142378,
0.02740379236638546,
0.030287187546491623,
-0.021590866148471832,
-0.03559263423085213,
0.007081619929522276,
0.026112031191587448,
-0.00028779893182218075,
-0.004400061909109354,
0.05402329936623573,
0.002992964582517743,
-0.0023845680989325047,
-0.007139287423342466,
-0.006055131088942289,
-0.021337127313017845,
0.0031919190660119057,
-0.024635732173919678,
0.0023168083280324936,
0.02373611368238926,
-0.044242821633815765,
0.028741687536239624,
-0.007225789595395327,
-0.006983584258705378,
0.017946254462003708,
0.004746069200336933,
-0.05563800409436226,
0.008540618233382702,
-0.015581870451569557,
-0.007202722132205963,
-0.032939910888671875,
0.00971127673983574,
-0.027842069044709206,
0.0015036908444017172,
0.021879205480217934,
-0.005380416288971901,
0.020379841327667236,
0.023055631667375565,
0.002433585934340954,
-0.010876168496906757,
-0.04112875461578369,
-0.022894160822033882,
-0.021925341337919235,
-0.01168928574770689,
-0.0072084893472492695,
0.05402329936623573,
0.0022202145773917437,
-0.0018323978874832392,
0.03580024093389511,
0.045004040002822876,
-0.0004984670085832477,
-0.013436623848974705,
-0.010039983317255974,
0.002161104930564761,
-0.00576967466622591,
0.005143977701663971,
0.10970743745565414,
-0.027726732194423676,
-0.025535352528095245,
-0.03259390592575073,
0.002998731564730406,
-0.005267963744699955,
0.027911270037293434,
0.025881359353661537,
0.0329168438911438,
-0.010178386233747005,
0.03965245559811592,
0.028972359374165535,
0.02569682151079178,
0.011204875074326992,
0.025581486523151398,
-0.01360962726175785,
0.01792318746447563,
0.008713621646165848,
-0.004682634491473436,
-0.017519511282444,
0.002838703105226159,
0.018096191808581352,
-0.020149169489741325,
0.02687324769794941,
-0.03084079921245575,
-0.00630310270935297,
-0.011354812420904636,
-0.01622775010764599,
-0.011118373833596706,
0.01580100879073143,
0.007202722132205963,
0.00611279858276248,
0.028026605024933815,
-0.001663719303905964,
0.013632694259285927,
-0.04456576332449913,
-0.013748030178248882,
-0.027126986533403397,
-0.017715582624077797,
0.00025247732992284,
0.013978702016174793,
0.0023528507445007563,
-0.006908616051077843,
0.006591442506760359,
0.008188843727111816,
-0.0061762332916259766,
-0.02834954671561718,
-0.02267502434551716,
0.002574872225522995,
-0.030748531222343445,
0.014059437438845634,
-0.03160201758146286,
0.0035148593597114086,
0.006545308046042919,
-0.0329168438911438,
-0.0032034525647759438,
0.027542196214199066,
-0.018315330147743225,
0.014094037935137749,
-0.04105955362319946,
-0.012133329175412655,
0.05633001774549484,
0.036722928285598755,
0.005135327577590942,
0.015639537945389748
] | 2024-07-02 | 48 | 38953982 | [
"metastatic tumors",
"tumor volume",
"tumor lesions",
"distal tumors",
"tumor growth",
"solid tumors",
"intratumoral virus injection",
"intratumoral injection",
"superior anti-tumor effects",
"CAR-T cells",
"HSV",
"oncolytic viruses",
"a bilateral subcutaneous tumor model",
"HSV-1-infected CAR-T cells",
"enhanced T-cell infiltration",
"B7-H3 CAR-T cells",
"intravenous infusion",
"mice",
"Recent studies",
"both immunocompromised and immunocompetent GBM orthotopic mouse models",
"therapy",
"challenges",
"GBM",
"B7-H3 CAR-",
"the localized delivery method",
"Hence, CAR-T",
"the injected side",
"a significant reduction",
"a promising approach",
"significantly prolonged survival"
] | [
"B7-H3",
"CAR-T",
"HSV",
"Oncolytic virotherapy",
"Systemic delivery"
] | 0 | 10.1007/s00262-024-03757-8
10.1056/NEJMoa1709866
10.1038/s41375-023-02042-4
10.1038/s41571-023-00832-4
10.1055/a-2010-5457
10.1038/s41467-022-34395-2
10.1016/j.ccell.2022.09.015
10.1016/j.ccell.2019.05.004
10.1038/s41423-021-00655-2
10.1186/s13045-022-01349-6
10.1016/j.ccell.2021.08.008
10.1136/jitc-2021-004219
10.1038/s41467-022-28523-1
10.1016/j.trecan.2022.10.003
10.1038/s41392-022-00951-x
10.3390/cells10061541
10.1136/jitc-2022-006270
10.1038/s41467-022-31262-y
10.1038/s41591-022-01897-x
10.1016/j.omto.2022.07.006
10.3389/fonc.2022.1037934
10.1038/s43018-022-00448-0
10.1172/Jci122287
10.1016/j.omto.2019.10.007
10.1038/sj.gt.3303098
10.1038/nm1297
10.1126/scitranslmed.abn2231
10.1016/j.ccell.2022.08.001
10.1158/1078-0432.Ccr-18-0432
10.1016/j.ccell.2019.01.002
10.1016/j.ebiom.2019.08.030
10.1002/cti2.1137
10.1016/j.ymthe.2022.08.021
10.1200/Jco.22.00343
10.1136/jitc-2023-007905
10.1038/s41417-022-00469-y
10.1126/scitranslmed.abc6659
10.1038/s41467-022-34357-8
10.1016/j.omto.2021.02.007
10.1080/14728222.2023.2259102
10.1016/j.nantod.2022.101671
10.1016/j.nano.2021.102506
10.1021/acs.molpharmaceut.8b01046
10.1007/s12274-021-4031-6
10.1002/0471142905.hg1311s85
10.1038/cgt.2012.21
10.1016/s1470-2045(21)00245-x
10.1016/j.ccell.2022.08.001
10.1016/j.cytogfr.2010.02.004 | [
"Zhang",
"Yang",
"Xu",
"Lu",
"Chen",
"Wang",
"Lu",
"Zhong",
"Zhu",
"Wang",
"Li",
"Zheng",
"Zhou",
"Tong"
] | [
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"Department of Ophthalmology, West China Hospital, Sichuan University, West China Medical School, Chengdu, 610041, Sichuan, China.",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.",
"Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan, China.",
"Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan, China. [email protected].\nDepartment of Neurosurgery, Fifth People's Hospital of Ningxia Hui Autonomous Region, Shizuishan, 753000, Ningxia, China. [email protected].\nDepartment of Neurosurgery, Mianyang Central Hospital, Mianyang, 621000, Sichuan, China. [email protected].",
"State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China. [email protected].\nFrontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, 610212, China. [email protected]."
] | [
"38953982",
"29385370",
"37880478",
"37904019",
"36333338",
"36270275",
"31185212",
"33785843",
"36115986",
"34506739",
"36104099",
"35177622",
"36402738",
"35387984",
"34207386",
"37142291",
"35864115",
"35864254",
"35991754",
"36353540",
"36357700",
"30829653",
"31872046",
"18305577",
"16170322",
"36027915",
"35417192",
"36027915",
"30655315",
"30753824",
"31466914",
"32547742",
"36056553",
"35998300",
"38135348",
"35444290",
"33239388",
"36333321",
"33738337",
"37742281",
"34875352",
"30604617",
"35194488",
"25827347",
"22555507",
"34214495",
"36027915",
"20226717"
] | [] | 10.173681 | 3.959465 |
38953939 | 785 | In vitro CAR-T cell killing: validation of the potency assay. | For advanced therapy medicinal products, the development and validation of potency assays are required, in accordance with international guidelines, to characterise the product and obtain reliable and consistent data. Our purpose was to validate the killing assay for the evaluation of autologous anti-CD19 chimeric antigen receptor (CAR) T potency. We used CD4 + and CD8 + lymphocytes or anti-CD19 CAR-T cells as effector cells and REH (CD19 +) or MOLM-13 (CD19 -) cell lines as target cells. After co-culturing target and effector cells (1:1 ratio) for 24 h, samples were labelled with 7-AAD, anti-CD3 and anti-CD19 antibodies and the frequency of CD19 + dead cells was evaluated by flow cytometry. In order to verify the CAR-T specificity for the CD19 + target, the co-culture between CAR-T and REH or MOLM-13 at different effector-to-target ratios was scheduled. Moreover, not transduced CD4 + and CD8 + lymphocytes were tested in comparison with CAR-T from the same donor to demonstrate the assay specificity. Linearity and accuracy were evaluated, and established acceptance criteria were compiled for both parameters (r | [
0.017068233340978622,
0.015113230794668198,
0.04048144817352295,
0.009365285746753216,
-0.018578385934233665,
-0.027112502604722977,
-0.02205524779856205,
-0.012689962983131409,
0.024794595316052437,
-0.01642437092959881,
0.003342236392199993,
0.02125919982790947,
-0.054880574345588684,
-0.005475765559822321,
0.015101524069905281,
-0.05647267401218414,
0.02648034691810608,
0.01396598294377327,
-0.017571618780493736,
0.023307856172323227,
0.034862276166677475,
-0.0017223346512764692,
-0.0027627593372017145,
0.021680636331439018,
0.022066954523324966,
-0.05333530530333519,
0.04062192887067795,
-0.010173042304813862,
-0.022511806339025497,
-0.05029158666729927,
-0.014914218336343765,
-0.018192067742347717,
-0.013263585977256298,
0.002932505216449499,
-0.018121829256415367,
0.02430291660130024,
0.03507299721240997,
0.026831544935703278,
-0.03017963469028473,
-0.04738834872841835,
-0.0009811600903049111,
0.0073576029390096664,
0.001150905853137374,
0.058767169713974,
-0.04188624024391174,
-0.038421086966991425,
-0.011981712654232979,
-0.03308287262916565,
0.04076240584254265,
-0.02619938738644123,
-0.037765514105558395,
0.03612659126520157,
0.01693946123123169,
0.024419983848929405,
-0.02591842971742153,
0.05291386693716049,
0.003980246372520924,
0.0007850743713788688,
0.004905068781226873,
0.03408963978290558,
0.016787275671958923,
0.013696731068193913,
0.01130272913724184,
-0.025590643286705017,
-0.06232597678899765,
0.011624661274254322,
-0.04912092536687851,
-0.03961516171693802,
0.01956174150109291,
0.06312202662229538,
0.024911660701036453,
0.03170149400830269,
0.008387784473598003,
-0.005086521152406931,
0.002566673792898655,
0.027370048686861992,
-0.01773551106452942,
0.02533309906721115,
-0.00645619397982955,
0.011238343082368374,
-0.014914218336343765,
-0.02460728958249092,
-0.01320505328476429,
-0.05572345107793808,
0.015136643312871456,
-0.0011940739350393414,
0.013111400417983532,
-0.045093853026628494,
-0.03722701221704483,
0.02084946818649769,
-0.02851729653775692,
0.04689667001366615,
-0.004299251828342676,
0.05160272493958473,
-0.01707994006574154,
-0.021938182413578033,
-0.02046314999461174,
-0.04968284070491791,
0.012104632332921028,
0.016681915149092674,
0.05680045858025551,
0.023998545482754707,
-0.0022623019758611917,
-0.0011991956271231174,
0.0222659669816494,
0.01658826321363449,
-0.029406998306512833,
-0.0005553321680054069,
-0.004729469306766987,
-0.010547653771936893,
0.08283595740795135,
-0.029851850122213364,
-0.01707994006574154,
0.017794042825698853,
-0.0009833549847826362,
-0.04874631389975548,
-0.003034937893971801,
-0.019713927060365677,
-0.005215293727815151,
-0.001514542382210493,
-0.019351022318005562,
0.022137194871902466,
0.047271281480789185,
-0.05562979727983475,
0.040153663605451584,
0.014352301135659218,
0.0577838160097599,
-0.019444674253463745,
-0.038631804287433624,
-0.06129579618573189,
0.013942569494247437,
-0.013661610893905163,
0.03919372335076332,
-0.0289621464908123,
-0.04286959767341614,
0.024349743500351906,
-0.007615148089826107,
0.0033978428691625595,
-0.036758746951818466,
-0.020369496196508408,
0.03172490745782852,
-0.005923543591052294,
-0.011700754053890705,
0.029547477141022682,
-0.034066226333379745,
-0.05333530530333519,
-0.03423012048006058,
0.013146520592272282,
-0.011653928086161613,
0.017571618780493736,
-0.03090544417500496,
0.04804391786456108,
0.01777062937617302,
-0.02281617745757103,
0.00526212016120553,
-0.026901783421635628,
-0.003087617689743638,
0.05689411237835884,
-0.02641010656952858,
-0.07084839046001434,
-0.01579221338033676,
-0.024115610867738724,
-0.03701629489660263,
-0.02281617745757103,
-0.02748711407184601,
0.0002544357848819345,
0.019269075244665146,
0.021177252754569054,
-0.06696179509162903,
0.028259750455617905,
-0.005847450345754623,
-0.02364734746515751,
-0.040668755769729614,
-0.058767169713974,
-0.034721799194812775,
0.022898124530911446,
0.01811012253165245,
0.053382132202386856,
-0.06003148481249809,
-0.01929248869419098,
-0.0007016647723503411,
-0.016681915149092674,
0.029922088608145714,
-0.026714477688074112,
-0.02242985926568508,
0.01151344832032919,
-0.038561563938856125,
0.02467752806842327,
-0.041769176721572876,
-0.032403890043497086,
0.026808131486177444,
-0.016681915149092674,
0.051415421068668365,
0.020369496196508408,
0.016061466187238693,
-0.050619371235370636,
0.04188624024391174,
0.015487841330468655,
-0.028259750455617905,
-0.03680557385087013,
-0.005982076283544302,
-0.03462814539670944,
-0.04511726647615433,
-0.0010133532341569662,
-0.0145161934196949,
0.010553507134318352,
-0.015335655771195889,
0.006175235379487276,
-0.015206882730126381,
-0.03209951892495155,
0.07225318253040314,
-0.019866112619638443,
-0.03647778928279877,
0.042401332408189774,
0.0036846548318862915,
-0.014539606869220734,
-0.02242985926568508,
0.043501753360033035,
0.014961044304072857,
0.019304195418953896,
-0.06176406145095825,
-0.004984088242053986,
0.01116225030273199,
0.005671851336956024,
-0.0032895568292587996,
0.04642840474843979,
0.04038779437541962,
-0.04303348809480667,
-0.005446499213576317,
-0.059469565749168396,
0.004793855827301741,
0.023659054189920425,
-0.011127130128443241,
-0.03062448464334011,
0.003312970045953989,
-0.017548205330967903,
0.0004016829770989716,
0.020767521113157272,
0.03860839083790779,
-0.014621553011238575,
0.0026661797892302275,
0.0028227558359503746,
0.03767186403274536,
-0.04282277077436447,
-0.02212548814713955,
-0.012783615849912167,
0.00419974559918046,
-0.05595758557319641,
0.015499548055231571,
-0.029922088608145714,
0.012760202400386333,
-0.042635463178157806,
0.004507043864578009,
-0.017817456275224686,
-0.0027773927431553602,
0.014422540552914143,
0.02129432000219822,
-0.04987014830112457,
-0.013298706151545048,
-0.05132176727056503,
-0.014668378978967667,
0.018882757052779198,
-0.01651802286505699,
-0.036313895136117935,
-0.04338468611240387,
0.04715421423316002,
-0.014586432836949825,
0.053007520735263824,
-0.008908728137612343,
0.000008522730240656529,
0.010998358018696308,
0.004255351610481739,
0.031678080558776855,
-0.026527171954512596,
-0.03811671584844589,
0.024068785831332207,
-0.007427842356264591,
0.035307127982378006,
-0.002685203216969967,
0.03287215530872345,
-0.032333649694919586,
-0.01099250465631485,
-0.024396570399403572,
-0.0009804284200072289,
-0.030132807791233063,
0.019432969391345978,
0.01277190912514925,
-0.014141581952571869,
-0.004984088242053986,
0.00399195309728384,
-0.0038719603326171637,
-0.01651802286505699,
0.0023574181832373142,
-0.0445319339632988,
-0.00985111016780138,
-0.015944398939609528,
-0.013521132059395313,
-0.015312242321670055,
-0.05825207754969597,
0.007656121160835028,
-0.007105910684913397,
0.021235786378383636,
0.004299251828342676,
-0.02648034691810608,
0.010032562538981438,
0.011776846833527088,
-0.015265416353940964,
-0.00747466878965497,
0.020720696076750755,
0.02982843667268753,
0.04968284070491791,
0.02271081879734993,
-0.0004986283020116389,
0.0044777775183320045,
-0.0022959583438932896,
-0.013263585977256298,
-0.01189391314983368,
-0.052070990204811096,
0.005540152080357075,
-0.023963425308465958,
-0.04050486162304878,
-0.0446021743118763,
-0.008294131606817245,
0.0019330536015331745,
0.009856963530182838,
-0.02067386917769909,
0.024139024317264557,
-0.03725042566657066,
0.005472838878631592,
-0.03612659126520157,
0.015101524069905281,
-0.007907813414931297,
0.04134773835539818,
-0.01777062937617302,
0.010553507134318352,
0.023600520566105843,
-0.03874887153506279,
-0.045304570347070694,
0.024045372381806374,
0.012689962983131409,
-0.027885138988494873,
0.03179514780640602,
-0.02830657735466957,
0.05127494037151337,
0.04237791895866394,
-0.0013316265540197492,
-0.006508873775601387,
0.00979843083769083,
0.04371247440576553,
0.020158778876066208,
0.013263585977256298,
0.009019941091537476,
-0.0025359438732266426,
-0.008147798478603363,
0.023553693667054176,
-0.009827696718275547,
-0.020861174911260605,
0.015698561444878578,
0.002031096490100026,
0.030366940423846245,
-0.00514212716370821,
0.012959214858710766,
-0.004612403456121683,
0.03401940315961838,
0.05520836263895035,
0.05984417721629143,
0.0048582423478364944,
-0.0011406625853851438,
-0.049308229237794876,
-0.04846535623073578,
-0.0027803191915154457,
0.011852940544486046,
0.005900130141526461,
0.033644791692495346,
-0.03844450041651726,
0.012092925608158112,
0.006069875787943602,
0.02699543721973896,
0.026456933468580246,
-0.010635453276336193,
0.06991185992956161,
-0.0006028902716934681,
0.029360171407461166,
-0.015534668229520321,
0.013731850311160088,
-0.01568685472011566,
0.0035500286612659693,
0.006473754066973925,
-0.06368394196033478,
0.03568173944950104,
-0.000429851992521435,
-0.027838312089443207,
-0.009552591480314732,
-0.025379925966262817,
-0.008340957574546337,
0.040153663605451584,
0.0034300358965992928,
0.10573408007621765,
0.03725042566657066,
-0.01876569166779518,
-0.035658325999975204,
-0.015757093206048012,
-0.06124896928668022,
-0.014574726112186909,
0.022207435220479965,
0.011449062265455723,
0.015382482670247555,
-0.02104848064482212,
0.04809074476361275,
0.007732214406132698,
0.003377356333658099,
0.036548029631376266,
0.03294239193201065,
-0.011794406920671463,
0.017477964982390404,
-0.024396570399403572,
0.01465667225420475,
0.0735643208026886,
0.027042264118790627,
-0.0020267064683139324,
-0.026386693120002747,
-0.04642840474843979,
0.00467678951099515,
-0.004553870297968388,
-0.00801902636885643,
-0.014586432836949825,
0.04570259526371956,
0.0290323868393898,
-0.000018554515918367542,
-0.037554796785116196,
-0.045023612678050995,
0.04614744707942009,
0.002230108715593815,
-0.02381123974919319,
-0.04912092536687851,
0.044578760862350464,
-0.015675147995352745,
-0.006514727137982845,
-0.033270180225372314,
0.015429308637976646,
-0.011408088728785515,
-0.017536498606204987,
-0.022769352421164513,
-0.03673533350229263,
-0.011033477261662483,
0.012514363043010235,
0.003672948107123375,
-0.02648034691810608,
-0.0019154936308041215,
0.019994886592030525,
-0.025567231699824333,
-0.003023231402039528,
-0.014012808911502361,
-0.017325779423117638,
-0.01638925075531006,
-0.004562650341540575,
0.02502872608602047,
-0.049823321402072906,
0.023003483191132545,
-0.009897937066853046,
0.0042377919889986515,
-0.021551864221692085,
0.01856667920947075,
-0.004413390997797251,
0.0014999090926721692,
0.07052060216665268,
0.06012513488531113,
-0.021692343056201935,
0.0374143160879612,
-0.035658325999975204,
0.008967261761426926,
-0.01593269221484661,
-0.03490910306572914,
0.03912348300218582,
-0.03977905213832855,
0.010606186464428902,
-0.0016974580939859152,
-0.0013162617105990648,
0.04954236373305321,
-0.011648074723780155,
-0.029126038774847984,
-0.03591587021946907,
-0.042635463178157806,
-0.009254073724150658,
0.03245071694254875,
0.04172234982252121,
-0.01755991205573082,
0.0050309146754443645,
-0.047271281480789185,
0.012432416900992393,
0.03149077296257019,
0.00734589621424675,
0.027042264118790627,
-0.010635453276336193,
-0.030882030725479126,
-0.02170404978096485,
0.047997090965509415,
-0.00165502168238163,
-0.009880376979708672,
0.03837426006793976,
-0.01690434105694294,
0.017466258257627487,
0.04062192887067795,
0.03804647549986839,
0.029570890590548515,
0.015885867178440094,
0.016506316140294075,
0.020076831802725792,
0.024654114618897438,
0.012514363043010235,
-0.011999272741377354,
-0.013521132059395313,
-0.0034417426213622093,
-0.06138944998383522,
-0.057221896946430206,
-0.01439912710338831,
-0.023108843713998795,
0.017021406441926956,
-0.015604907646775246,
0.02619938738644123,
-0.03221658244729042,
-0.01759503036737442,
-0.003468082519248128,
0.04022390395402908,
0.00144283939152956,
-0.0368524007499218,
-0.008124385960400105,
-0.030015742406249046,
-0.06021878868341446,
-0.031748320907354355,
0.026527171954512596,
-0.013942569494247437,
-0.03814012557268143,
-0.003968540113419294,
0.013474305160343647,
-0.01586245372891426,
-0.019854405894875526,
0.0221606083214283,
-0.00947064533829689,
-0.04795026406645775,
0.02046314999461174,
-0.03996635973453522,
0.019351022318005562,
-0.030601071193814278,
-0.009581858292222023,
0.02453704923391342,
0.001558442134410143,
-0.028259750455617905,
0.01014377549290657,
-0.025145793333649635,
0.006356687750667334,
-0.016201945021748543,
0.030718138441443443,
0.0030993244145065546,
0.005756724160164595,
0.0041909655556082726,
-0.021107014268636703,
-0.04455534741282463,
-0.023975132033228874,
-0.04724786803126335,
-0.02830657735466957,
-0.009441378526389599,
-0.01676386222243309,
-0.03504958376288414,
-0.017536498606204987,
0.03788258135318756,
-0.0009892083471640944,
0.007960492745041847,
-0.04525774344801903,
0.03249754384160042,
0.01346259843558073,
0.008411197923123837,
-0.03017963469028473,
-0.0368524007499218,
0.04766930639743805,
0.02299177646636963,
-0.008563383482396603,
-0.028353404253721237,
-0.007755627389997244,
0.012643136084079742,
-0.007989759556949139,
0.00013243099965620786,
-0.0369226410984993,
0.008738982491195202,
-0.017103353515267372,
0.022933244705200195,
-0.02713591605424881,
-0.014937630854547024,
-0.008054145611822605,
0.009172126650810242,
0.005777210928499699,
0.027463700622320175,
0.04556211829185486,
-0.013872330076992512,
-0.013404065743088722,
0.008674596436321735,
0.009019941091537476,
0.009482352063059807,
-0.00879751518368721,
-0.011800260283052921,
0.02879825420677662,
-0.00017953179485630244,
-0.0023310782853513956,
-0.0187071580439806,
-0.01811012253165245,
0.03516664728522301,
-0.009482352063059807,
-0.025450164452195168,
-0.015101524069905281,
-0.008826781995594501,
0.037765514105558395,
0.005279679782688618,
-0.03163125365972519,
-0.012174871750175953,
0.020404616370797157,
0.02139967866241932,
-0.04085605964064598,
0.024794595316052437,
-0.012982627376914024,
-0.017723804339766502,
-0.04635816439986229,
-0.01603805273771286,
-0.01952662132680416,
-0.022172315046191216,
0.027557354420423508,
-0.00822389218956232,
-0.017548205330967903,
0.008809221908450127,
-0.019315902143716812,
0.02821292355656624,
-0.0025549670681357384,
-0.00979843083769083,
-0.01748967170715332,
0.004466070793569088,
0.011490034870803356,
-0.04137115180492401,
0.04216720163822174,
-0.03701629489660263,
-0.022383034229278564,
0.0026105735450983047,
0.03535395488142967,
0.02474776841700077,
0.008270718157291412,
-0.0015920986188575625,
0.026667652651667595,
0.009657951071858406,
-0.02381123974919319,
-0.020229017361998558,
0.010260841809213161,
-0.013649904169142246,
-0.011296876706182957,
-0.009892083704471588,
0.004916775040328503,
0.0017618443816900253,
0.017021406441926956,
-0.026714477688074112,
-0.03940444067120552,
0.018297428265213966,
0.03228682279586792,
0.05544249340891838,
-0.019924646243453026,
0.011431502178311348,
-0.0018876905087381601,
0.0011479791719466448,
0.01897641085088253,
-0.001017743139527738,
0.024841420352458954,
-0.014024515636265278,
0.012970921583473682,
0.005437719170004129,
0.041183844208717346,
0.007211270276457071,
-0.016611676663160324,
-0.013298706151545048,
-0.013286999426782131,
-0.03273167461156845,
0.004006586503237486,
-0.03315311297774315,
-0.04549187794327736,
0.004269985016435385,
0.020755814388394356,
0.021095307543873787,
-0.02299177646636963,
-0.07150395959615707,
0.003116884268820286,
-0.009564298205077648,
0.06953725218772888,
0.0027086164336651564,
0.0061635286547243595,
-0.016635090112686157,
-0.020662162452936172,
-0.03301263228058815,
0.0032837034668773413,
-0.0017530644545331597,
0.002531553851440549,
0.025356512516736984,
-0.01379038393497467,
-0.006140115670859814,
-0.0031081042252480984,
-0.016892634332180023,
0.016014639288187027,
0.008024879731237888,
0.06663400679826736,
-0.03132688254117966,
0.005227000452578068,
-0.012116339057683945,
-0.02444339729845524,
-0.05015110597014427,
0.0022930316627025604,
0.04448510706424713,
0.009336019866168499,
0.002868118928745389,
-0.03860839083790779,
-0.023319562897086143,
-0.01151344832032919,
0.027018850669264793,
-0.012350470758974552,
0.03231023624539375,
0.013509425334632397,
0.015698561444878578,
0.022511806339025497,
0.02150503732264042,
-0.014457660727202892,
0.011852940544486046,
0.03877228498458862,
0.03818695247173309,
-0.003321749856695533,
0.07468815892934799,
-0.004828975535929203,
-0.01600293256342411,
-0.004539236892014742,
-0.012807028368115425,
-0.03357455134391785,
-0.007901960052549839,
-0.005314799956977367,
0.008733129128813744,
-0.030296700075268745,
-0.01798134855926037,
-0.013193346560001373,
0.009137007407844067,
0.039006415754556656,
-0.004586063325405121,
-0.03802306205034256,
-0.011571981944143772,
-0.01512493658810854,
0.016775568947196007,
0.023588813841342926,
0.017817456275224686,
0.001909640384837985,
-0.002175965579226613,
0.009827696718275547,
0.007632708176970482,
-0.015604907646775246,
0.023483455181121826,
0.01589757390320301,
-0.04949553683400154,
-0.022980069741606712,
0.013450891710817814,
-0.0032398037146776915,
0.010500826872885227,
-0.030085980892181396,
0.01026669517159462,
0.023249322548508644,
0.0009496985585428774,
0.00108212954364717,
0.03497934341430664,
-0.004413390997797251,
0.019866112619638443,
0.00260911020450294,
0.018824225291609764,
-0.02699543721973896,
-0.019432969391345978,
0.02067386917769909,
-0.004357784520834684,
-0.017197007313370705,
0.026246214285492897,
-0.018648626282811165,
-0.0032046837732195854,
-0.03083520382642746,
0.0043811979703605175,
-0.006333274766802788,
-0.012373884208500385,
0.009880376979708672,
0.0063742478378117085,
0.01501957792788744,
-0.01970222033560276,
-0.035307127982378006,
0.02205524779856205,
-0.007410282734781504,
0.009810137562453747,
-0.015323949046432972,
0.024139024317264557,
-0.02329614944756031,
0.011296876706182957,
0.009189686737954617,
-0.019339315593242645,
0.024068785831332207,
-0.08606697618961334,
0.021856237202882767,
-0.03205269202589989,
-0.0443914569914341,
-0.016330717131495476,
0.020884588360786438,
-0.04736493527889252,
0.0026193533558398485,
-0.014574726112186909,
-0.024139024317264557,
0.01631901040673256,
0.0048670219257473946,
-0.009605271741747856,
0.009587711654603481,
0.0033627229277044535,
-0.0017955009825527668,
-0.04092629998922348,
-0.0366416834294796,
-0.0090901805087924,
0.03561149910092354,
0.006631792988628149,
0.01393086276948452,
-0.021973302587866783,
0.01915200985968113,
-0.005194806959480047,
0.01270166877657175,
-0.01069983933120966,
-0.003912933636456728,
-0.023764412850141525,
-0.0011370042338967323,
0.01379038393497467,
0.007679534610360861,
-0.019163716584444046,
-0.005227000452578068,
-0.016459491103887558,
-0.04448510706424713,
0.012725082226097584,
-0.026175973936915398,
0.006304007954895496,
-0.0024320476222783327,
-0.010313521139323711,
0.010553507134318352,
0.03003915585577488,
0.007035671267658472,
0.016237065196037292,
0.0023603446315973997,
-0.043056901544332504,
0.019175423309206963,
-0.007340042851865292,
-0.03170149400830269,
0.012397297658026218,
-0.021446505561470985,
-0.0033539431169629097,
0.013111400417983532,
-0.0068132453598082066,
0.008358517661690712,
-0.013263585977256298,
0.022874711081385612,
-0.020896295085549355,
-0.008850195445120335,
-0.006625940091907978,
0.06878802925348282,
0.03514323756098747,
-0.017302365973591805,
0.00888531468808651,
-0.020346084609627724,
-0.05717507004737854,
0.026714477688074112,
-0.017922816798090935,
0.04029414430260658,
-0.009142860770225525,
0.006772272288799286,
-0.009576004929840565,
0.007240536622703075,
-0.009400405921041965,
0.03172490745782852,
-0.012549483217298985,
-0.03415988013148308,
0.004463144112378359,
-0.00203987630084157,
-0.02685495838522911,
-0.027674419805407524,
0.0007660511182621121,
0.014469366520643234,
-0.026012081652879715,
-0.001308945007622242,
0.016201945021748543,
0.0062045021913945675,
0.03090544417500496,
-0.014071342535316944,
-0.00750978896394372,
-0.012795321643352509,
0.003582221921533346,
0.011408088728785515,
-0.018051588907837868,
-0.025426751002669334,
-0.025707710534334183,
-0.008463877253234386,
-0.00037186770350672305,
-0.000407536281272769,
0.007141030393540859,
-0.05174320563673973,
0.03191221132874489,
-0.048793140798807144,
-0.016845807433128357,
-0.0038836670573800802,
0.03547102212905884,
-0.03814012557268143,
-0.00012273647007532418,
-0.01465667225420475,
0.042494986206293106,
0.0057069710455834866,
0.015429308637976646,
0.0031490775290876627,
0.010828612372279167,
0.015054697170853615,
0.013123107142746449,
-0.01607317291200161,
0.0021627957466989756,
-0.005674778018146753,
0.04579624906182289,
0.011261756531894207,
-0.02481800876557827,
-0.05253925547003746,
-0.021610397845506668,
0.009985736571252346,
-0.00007101703522494063,
0.022277673706412315,
-0.0014025978744029999,
0.005464059300720692,
0.022113781422376633,
0.004234865307807922,
-0.0017062380211427808,
-0.04055168852210045,
-0.031959038227796555,
0.01607317291200161,
0.04750541225075722,
0.003169564064592123,
-0.016564849764108658,
-0.010500826872885227,
0.00857509020715952,
0.02568429708480835,
0.015920985490083694,
-0.005475765559822321,
0.027908552438020706,
-0.028845081105828285,
-0.02516920678317547,
0.02111871913075447,
0.024560462683439255,
-0.004062192980200052,
-0.0503852404654026,
0.012924094684422016,
0.028400229290127754,
0.015218589454889297,
0.003231023671105504,
0.027533940970897675,
0.0017135547241196036,
-0.024419983848929405,
-0.003953906707465649,
-0.018742278218269348,
-0.022511806339025497,
0.04532798379659653,
-0.0360095240175724,
0.019233956933021545,
0.021867942065000534,
-0.013567958027124405,
-0.011847087182104588,
-0.00032595585798844695,
0.034651558846235275,
0.009997443296015263,
0.036899227648973465,
-0.05272655934095383,
0.0366416834294796,
-0.028025617823004723,
-0.022687405347824097,
0.019760753959417343,
0.012116339057683945,
-0.00025900869513861835,
0.010559359565377235,
0.009944763034582138,
-0.03975563868880272,
0.01894129067659378,
0.009962323121726513,
0.015710268169641495,
0.04244815930724144,
-0.009979883208870888,
0.001805744250304997,
-0.024326330050826073,
0.031022509559988976,
-0.0017750143306329846,
-0.028353404253721237,
-0.011291023343801498,
0.006655206438153982,
0.07815331220626831,
0.05422500520944595,
-0.050947155803442,
-0.006286448333412409,
0.005783064290881157,
-0.04027073085308075,
-0.03200586512684822,
-0.025637470185756683,
0.012924094684422016,
0.04921457916498184,
-0.01644778437912464,
-0.012209991924464703,
-0.00205597304739058,
0.007269803434610367,
-0.03216975927352905,
-0.0004250961937941611,
0.05127494037151337,
0.03788258135318756,
0.0009935983689501882,
-0.02035779133439064,
0.04645181819796562,
0.022113781422376633,
-0.029547477141022682,
-0.01672874204814434,
0.0015057623386383057,
-0.03750796988606453,
-0.02139967866241932,
-0.04535139724612236,
-0.02692519687116146,
0.0004214378714095801,
-0.02143479883670807,
0.0009109203820116818,
-0.018753984943032265,
0.031514186412096024,
-0.0017369679408147931,
0.007328336127102375,
0.04179259017109871,
-0.035377368330955505,
0.019397849217057228,
0.016670208424329758,
0.0004850925470236689,
0.01582733355462551,
-0.010518386960029602,
0.008083412423729897,
-0.015394188463687897,
0.014715205878019333,
-0.025707710534334183,
0.03844450041651726,
0.007621001452207565,
-0.02271081879734993,
-0.004223158583045006,
-0.013158227317035198,
0.024560462683439255,
0.03301263228058815,
-0.010875438340008259,
0.0026837398763746023,
0.0057274578139185905,
-0.011981712654232979,
-0.013614784926176071,
0.024630703032016754,
0.010073536075651646,
0.05595758557319641,
-0.0025052139535546303,
0.023272735998034477,
0.014961044304072857,
0.0015306388959288597,
0.012280231341719627,
-0.013333826325833797,
0.033785268664360046,
-0.02053339034318924,
-0.01922225020825863,
0.015405895188450813,
-0.027440287172794342,
0.013134813867509365,
-0.010998358018696308,
0.027370048686861992,
0.00784342736005783,
0.043852951377630234,
-0.01418840792030096,
0.018777398392558098,
0.027674419805407524,
-0.01672874204814434,
-0.010658865794539452,
0.043501753360033035,
-0.000894092139787972,
-0.027089089155197144,
-0.002086702734231949,
-0.00375489448197186,
-0.01048912014812231,
-0.03732066601514816,
-0.008083412423729897,
-0.00822389218956232,
-0.0015569787938147783,
-0.017548205330967903,
-0.023600520566105843,
-0.01991293951869011,
-0.023834653198719025,
-0.004878728650510311,
0.013392359018325806,
-0.04113701730966568,
-0.01566344127058983,
-0.007732214406132698,
-0.0019374435069039464,
-0.026152560487389565,
0.0060406094416975975,
0.009336019866168499,
0.0074336957186460495,
-0.0009643317898735404,
0.028985559940338135,
-0.007328336127102375,
-0.059891004115343094,
-0.005464059300720692,
-0.025216031819581985,
-0.021306024864315987,
-0.04776296019554138,
0.04289301112294197,
-0.015803920105099678,
-0.03252095729112625,
0.009862816892564297,
0.030296700075268745,
0.0029895748011767864,
0.012139751575887203,
0.01247924380004406,
-0.03214634582400322,
0.033059459179639816,
-0.010535947047173977,
-0.008522409945726395,
-0.022289380431175232,
-0.03003915585577488,
-0.000684104859828949,
-0.0002103531005559489,
-0.04151162877678871,
0.01527712307870388,
0.00801902636885643,
0.01151344832032919,
-0.004747029393911362,
0.015616614371538162,
0.0254033375531435,
-0.031443946063518524,
0.006637646351009607,
0.008984820917248726,
0.02706567570567131,
0.032684847712516785,
-0.004106092732399702,
0.0011304193176329136,
-0.007503935601562262,
0.02184453047811985,
-0.015839040279388428,
-0.007615148089826107,
0.010214014910161495,
0.007585881743580103,
0.009423819370567799,
0.007679534610360861,
-0.013766970485448837,
-0.009476498700678349,
-0.052351947873830795,
-0.014047929085791111,
0.05174320563673973,
-0.009780870750546455,
-0.04013025015592575,
0.03956833481788635,
0.039802465587854385,
-0.016225358471274376,
0.005689411424100399,
0.014843977987766266,
-0.015312242321670055,
-0.009927202947437763,
-0.017337486147880554,
0.013158227317035198,
0.027229569852352142,
0.0017691610846668482,
-0.03432377427816391,
0.023670760914683342,
-0.015347362495958805,
-0.015031283721327782,
-0.00793122686445713,
0.037976235151290894,
0.0251926202327013,
-0.005147980526089668,
0.009289192967116833,
-0.013532837852835655,
0.028915321454405785,
-0.014445954002439976,
0.025005314499139786,
0.01593269221484661,
0.018063295632600784,
0.01908176951110363,
0.0021188959944993258,
0.0010162799153476954,
-0.008036586456000805,
-0.04577283561229706,
0.019339315593242645,
-0.03668850660324097,
-0.0258950162678957,
0.003216390497982502,
0.0010799345327541232,
-0.026691066101193428,
-0.009903790429234505,
-0.027533940970897675,
-0.0028286089655011892,
0.008048292249441147,
-0.031443946063518524,
0.019936352968215942,
-0.03577539324760437,
0.009669657796621323,
-0.013286999426782131,
0.012116339057683945,
-0.04558552801609039,
0.028564121574163437,
0.019725633785128593,
0.009306753054261208,
0.023342976346611977,
0.02844705618917942,
0.034370601177215576,
0.025848189368844032,
0.027370048686861992,
0.002072069561108947,
-0.014680085703730583,
-0.0009467718773521483,
-0.04221402853727341,
0.004767515696585178,
-0.0362202450633049,
-0.03186538442969322,
0.01379038393497467,
-0.026644239202141762,
-0.01925736851990223,
-0.024396570399403572,
0.021352851763367653,
-0.016752155497670174,
0.005068961065262556,
-0.012350470758974552,
-0.013392359018325806,
-0.0028666555881500244,
0.051555898040533066,
-0.012842148542404175,
-0.016400957480072975,
0.014680085703730583,
0.010383760556578636,
-0.010682279244065285,
0.007878546603024006,
-0.019643686711788177,
-0.051040809601545334,
-0.00772636104375124,
0.020720696076750755,
0.003670021425932646,
-0.010219868272542953,
0.03032011352479458,
-0.009663804434239864,
-0.015640027821063995,
0.03757821023464203,
0.019128596410155296,
0.0028783620800822973,
-0.030296700075268745,
-0.015522961504757404,
0.007661974523216486,
0.03214634582400322,
0.034136466681957245,
0.026503760367631912,
0.03809330239892006,
-0.014270354993641376,
0.016166824847459793,
0.007544908672571182,
-0.011507594957947731,
-0.025801362469792366,
-0.006391807924956083,
0.010594479739665985,
0.013006040826439857,
-0.029477238655090332,
-0.005335286259651184,
-0.019210543483495712,
0.032403890043497086,
-0.010898851789534092,
0.004015366546809673,
-0.012959214858710766,
-0.00042802284588105977,
-0.050806675106287,
-0.00556649174541235,
0.012818735092878342,
0.023659054189920425,
0.023518575355410576,
0.019866112619638443,
0.004258278291672468,
-0.012128045782446861,
0.01665850169956684,
0.008990674279630184,
-0.0007119080983102322,
-0.00008830257138470188,
-0.019889526069164276,
-0.010208161547780037,
0.016997994855046272,
0.00623962190002203,
0.012291938066482544,
0.008153651840984821,
-0.027604181319475174,
-0.033644791692495346,
0.03425353392958641,
0.01439912710338831,
0.015721973031759262,
-0.00862191617488861,
-0.015288829803466797,
0.001561368815600872,
-0.03444083780050278,
-0.005235780030488968,
-0.023776119574904442,
-0.024185851216316223,
0.008376077748835087,
0.03083520382642746,
-0.018274014815688133,
-0.006397660821676254,
0.002250595251098275,
-0.01911688968539238,
0.009458938613533974,
-0.002670569811016321,
-0.029196279123425484,
-0.02083776146173477,
-0.0005366748082451522,
0.030413765460252762,
-0.03961516171693802,
-0.008943848311901093,
-0.007287363056093454,
0.060546573251485825,
0.022663991898298264,
-0.07585881650447845,
0.003658314934000373,
-0.0023530281614512205,
0.02423267811536789,
-0.007860986515879631,
0.010541800409555435,
0.00793122686445713,
0.04783319681882858,
-0.04235450550913811,
0.00032869959250092506,
-0.01443424727767706,
-0.010887145064771175,
0.036103177815675735,
-0.06218549981713295,
0.01894129067659378,
0.014176702126860619,
-0.008668743073940277,
0.010067682713270187,
-0.012807028368115425,
-0.001959393499419093,
0.05441231280565262,
-0.015405895188450813,
-0.004337298218160868,
0.0008084875880740583,
0.027978792786598206,
-0.007574175018817186,
-0.0015701487427577376,
0.027440287172794342,
0.019105182960629463,
0.007439549081027508,
0.029289932921528816,
-0.0017867209389805794,
-0.046030379831790924,
0.007111764047294855,
0.04954236373305321,
0.019936352968215942,
-0.02706567570567131,
-0.012467537075281143,
0.007199563551694155,
-0.021446505561470985,
-0.02028755098581314,
-0.008288278244435787,
-0.03490910306572914,
-0.03895958885550499,
0.016752155497670174,
0.018742278218269348,
0.008458023890852928,
0.004492410458624363,
0.01908176951110363,
0.001647704979404807,
-0.000585330359172076,
0.023635640740394592,
-0.0005882570403628051,
0.003582221921533346,
0.0036349017173051834,
-0.04504702612757683,
-0.016962874680757523,
0.01494933757930994,
-0.022453272715210915,
-0.006713739596307278,
0.005437719170004129,
0.012128045782446861,
-0.0014457660727202892,
-0.007462962530553341,
-0.003936346620321274,
-0.011127130128443241,
-0.0005041157710365951,
-0.009862816892564297,
0.014785445295274258,
-0.0002121822617482394,
-0.026082322001457214,
-0.04757565259933472,
0.023834653198719025,
-0.017091646790504456,
0.013415772467851639,
-0.03767186403274536,
0.007252243347465992,
0.009429672732949257,
-0.009131154045462608,
0.0015394189395010471,
0.0006888606585562229,
0.007275656796991825,
-0.0015291755553334951,
-0.027768073603510857,
-0.0016125851543620229,
-0.024864833801984787,
0.01683410257101059,
-0.011501741595566273,
-0.013368945568799973,
0.00930089969187975,
0.021481625735759735,
0.0181803610175848,
-0.011361262761056423,
-0.0503852404654026,
-0.011847087182104588,
-0.015815626829862595,
0.0028812887612730265,
-0.0360095240175724,
-0.013837209902703762,
0.03298921883106232,
0.016260478645563126,
-0.024724354967474937,
-0.0011494425125420094,
-0.015511254779994488,
-0.0027100795414298773,
0.051087636500597,
0.026714477688074112,
-0.01480885874480009,
0.02727639488875866,
0.007960492745041847,
0.025848189368844032,
-0.009862816892564297,
-0.01180611364543438,
0.01226852461695671,
-0.03200586512684822,
-0.019058357924222946,
0.03097568266093731,
0.006918604951351881,
-0.02886849455535412,
0.003152003977447748,
-0.013251880183815956,
-0.008141945116221905,
-0.004463144112378359,
-0.02713591605424881,
0.018297428265213966,
-0.007047377526760101,
0.0255438182502985,
-0.004910921677947044,
0.04907409846782684,
0.00044229027116671205,
0.039521507918834686,
-0.021306024864315987,
-0.02357710711658001,
-0.0009365286095999181,
-0.00807170569896698,
-0.03191221132874489,
-0.014129875227808952,
0.0007909276755526662,
0.01218657847493887,
0.03483886271715164,
0.03198245167732239,
-0.00687763188034296,
0.014586432836949825,
-0.03750796988606453,
0.010477413423359394,
0.020545097067952156,
-0.0029383585788309574,
-0.007966346107423306,
0.003292483277618885,
0.009142860770225525,
-0.011220782995223999,
-0.029219692572951317,
-0.010500826872885227,
-0.01700970157980919,
-0.005449425894767046,
-0.05534883961081505,
-0.00412365235388279,
-0.03732066601514816,
-0.003172490745782852,
0.09262268245220184,
0.010729106143116951,
0.003927567042410374,
0.013310412876307964,
0.02800220437347889,
-0.016775568947196007,
0.012163165025413036,
0.0027334927581250668,
-0.008059998974204063,
-0.02035779133439064,
0.059329088777303696,
0.004384124651551247,
0.021282613277435303,
0.023424921557307243,
0.0014135728124529123,
-0.010465706698596478,
0.0031256643123924732,
0.039006415754556656,
0.012022686190903187,
-0.010190601460635662,
-0.004869948606938124,
-0.02823633700609207,
-0.02685495838522911,
0.02343662828207016,
-0.006942018400877714,
-0.024209264665842056,
-0.018473027274012566,
-0.012034392915666103,
-0.01959686167538166,
0.016225358471274376,
0.02568429708480835,
0.014036222361028194,
0.0033158964943140745,
-0.020310964435338974,
0.004126579035073519,
-0.01763015054166317,
-0.006608380004763603,
0.0012306571006774902,
0.0439700186252594,
-0.0008062925771810114,
0.002168649109080434,
-0.011987566016614437,
-0.019866112619638443,
-0.0055342987179756165,
0.01911688968539238,
-0.009652097709476948,
-0.021411385387182236,
0.04855900630354881,
0.015464428812265396,
-0.032544370740652084,
-0.025590643286705017,
0.002692519687116146,
0.008054145611822605,
-0.02678471803665161,
-0.038936175405979156,
0.00568648474290967,
0.017501378431916237,
-0.007410282734781504,
-0.015991225838661194,
-0.01873057149350643,
-0.011431502178311348,
0.0018584239296615124,
0.00883263535797596,
0.004992868285626173,
0.01480885874480009
] | 2024-07-02 | 12 | 38953939 | [
"autologous anti-CD19 chimeric antigen receptor",
"effector cells",
"target cells",
"anti-CD19 CAR-T cells",
"co-culturing target",
"potency assays",
"advanced therapy medicinal products",
"CD19",
"acceptance criteria",
"international guidelines",
"+",
"target",
"CD8",
"MOLM-13",
"REH",
"CAR-T",
"7-AAD, anti-CD3 and anti-CD19 antibodies",
"CD4",
"CD19 + dead cells",
"flow cytometry",
"validation",
"accordance",
"CAR) T potency",
"the assay specificity",
"the CAR-T specificity",
"samples",
"lymphocytes",
"comparison",
"accuracy",
"the killing assay"
] | [
"CAR-T",
"Killing",
"Potency",
"Validation"
] | 0 | 10.1007/s00262-024-03753-y
10.1016/j.jpba.2023.115397
10.3390/cancers15030663
10.1038/s41586-023-06243-w
10.1111/ijlh.14121
10.1038/s41598-017-18606-1
10.3791/59033
10.1038/s41596-020-00467-0
10.3389/fimmu.2023.1186224
10.3389/fmed.2023.1190016
10.1038/s41467-021-27312-6
10.1007/s11899-023-00687-7 | [
"Piccinini",
"Carloni",
"Arienti",
"Pancisi",
"Fanini",
"Pignatta",
"Soldati",
"Stefanelli",
"Granato",
"Martinelli",
"Ridolfi",
"Petrini"
] | [
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy.",
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy.",
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy.",
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy.",
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy.",
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy. [email protected].",
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy.",
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy.",
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy.",
"Scientific Direction, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Meldola, Italy.",
"Experimental and Clinical Oncology of Immunotherapy and Rare Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Meldola, Italy.",
"Immuno-Gene Therapy Factory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Via Maroncelli 40, 47014, Meldola, Italy."
] | [
"38953939",
"37079933",
"36765623",
"37495877",
"37337970",
"29317736",
"31789308",
"33589826",
"37359560",
"37215709",
"34893603",
"36763238"
] | [] | 7.621637 | 5.053821 |
38953027 | 786 | Broadening anticancer spectrum by preprocessing and treatment of T- lymphocytes expressed FcγRI and monoclonal antibodies for refractory cancers. | Chimeric antigen receptor T (CAR-T) cell therapies have achieved remarkable success in the treatment of hematological tumors. However, given the distinct features of solid tumors, particularly heterogeneity, metabolic aggressiveness, and fewer immune cells in tumor microenvironment (TME), the practical utility of CAR-T cells for solid tumors remains as a challenging issue. Meanwhile, although anti-PD-1 monoclonal antibody (mAb) has shown clinical efficacy, most mAbs also show limited clinical benefits for solid tumors due mainly to the issues associated with the lack of immune cells in TME. Thus, the infiltration of targeted immunological active cells into TME could generate synergistic efficacy for mAbs.
We present a combinational strategy for solid tumor treatment, which combines armored-T cells to express Fc-gamma receptor I (FcγRI) fragment on the surfaces for targeting various tumors with therapeutically useful mAbs. Choosing CD20 and HER-2 as the targets, we characterized the
The combination and preprocessing of armored T-cells with corresponding antibody of Rituximab and Pertuzumab exerted profound anti-tumor effects, which is demonstrated to be mediated by synergistically produced antibody-dependent cellular cytotoxicity (ADCC) effects. Meanwhile, mAb was able to carry armored-T cell by preprocessing for the infiltration to TME in cell derived xenograft (CDX) model.
This combination strategy showed a significant increase of safety profiles from the reduction of antibody doses. More importantly, the present strategy could be a versatile tool for a broad spectrum of cancer treatment, with a simple pairing of engineered T cells and a conventional antibody. | [
0.025806833058595657,
0.015955213457345963,
0.03641269728541374,
0.07695634663105011,
-0.03098212368786335,
-0.02589966356754303,
0.01214917004108429,
0.06447066366672516,
0.03047155775129795,
0.003005382139235735,
-0.02130456082522869,
-0.021107297390699387,
-0.051752910017967224,
-0.02478569932281971,
0.019633615389466286,
-0.02849891223013401,
0.037619493901729584,
-0.0026137540116906166,
-0.015885591506958008,
0.003121420042589307,
0.016210496425628662,
0.03330288082361221,
-0.01782342419028282,
-0.027292117476463318,
-0.028568536043167114,
-0.002999580232426524,
0.0024121382739394903,
0.01646578125655651,
-0.0158739872276783,
-0.04063647985458374,
0.03532194346189499,
-0.02441437728703022,
-0.022105222567915916,
-0.02924155443906784,
-0.010060487315058708,
0.050731778144836426,
0.022105222567915916,
0.026294192299246788,
-0.03211929649114609,
0.0004706788167823106,
0.016326535493135452,
0.020097767934203148,
0.027965137735009193,
0.08712127059698105,
-0.07236124575138092,
-0.007194350939244032,
-0.016512196511030197,
-0.04822535812854767,
0.013286341913044453,
-0.007026095874607563,
-0.018902577459812164,
0.006933265365660191,
-0.026944003999233246,
0.019239086657762527,
-0.04233063384890556,
0.00855199433863163,
-0.04177365079522133,
0.0038843692746013403,
-0.0043050069361925125,
0.01182426419109106,
-0.016454176977276802,
-0.022267676889896393,
0.02687438204884529,
-0.02777947671711445,
-0.05778688192367554,
0.010948177427053452,
-0.06131443753838539,
-0.04910724610090256,
-0.01770738698542118,
-0.00817487109452486,
0.007287181448191404,
-0.0431428961455822,
0.0006048476207070053,
0.016906725242733955,
0.031051747500896454,
-0.008952325209975243,
-0.001173433498479426,
0.044929880648851395,
-0.0056829568929970264,
-0.03666798025369644,
0.038965534418821335,
-0.023242395371198654,
0.023857396095991135,
-0.04906083270907402,
-0.03634307533502579,
-0.015456250868737698,
0.004252789542078972,
-0.03186401352286339,
-0.04785403609275818,
-0.017556536942720413,
0.0014120363630354404,
0.024507207795977592,
-0.04706497862935066,
0.028684573248028755,
-0.005839608144015074,
0.01060006394982338,
-0.02404305711388588,
-0.07212916761636734,
0.02924155443906784,
0.02453041635453701,
0.05811179056763649,
0.020422672852873802,
-0.025876455008983612,
-0.03838534280657768,
0.03237457945942879,
-0.024066263809800148,
-0.017660971730947495,
-0.007832559756934643,
0.014052191749215126,
0.011011998169124126,
0.06739482283592224,
-0.01957559585571289,
0.00690425606444478,
0.039220817387104034,
-0.0031475285068154335,
-0.05630159750580788,
-0.008876901119947433,
-0.0030605001375079155,
-0.006962275132536888,
0.03671439737081528,
0.005642343778163195,
0.021211732178926468,
0.02926476299762726,
-0.055837444961071014,
-0.004072931129485369,
-0.0431428961455822,
0.07022614777088165,
-0.04221459478139877,
-0.04089176282286644,
-0.04687931761145592,
0.023590508848428726,
-0.004136751871556044,
-0.020283428952097893,
0.0039017749950289726,
-0.05541970953345299,
-0.004998333286494017,
0.0025615370832383633,
-0.002706584520637989,
-0.013785304501652718,
-0.019552389159798622,
0.018658896908164024,
-0.029960989952087402,
0.01393615361303091,
-0.02094484493136406,
-0.06382085382938385,
-0.04868951067328453,
-0.020097767934203148,
0.011708226054906845,
0.010716102086007595,
0.023474471643567085,
-0.050128381699323654,
0.035391565412282944,
0.06971558183431625,
-0.007234964054077864,
0.017173612490296364,
-0.03861742094159126,
-0.004699535667896271,
0.0384085513651371,
-0.014458324760198593,
-0.057740468531847,
-0.022627394646406174,
0.0074670398607850075,
-0.04808611422777176,
-0.013924550265073776,
0.041332706809043884,
-0.008192276582121849,
-0.0059411413967609406,
0.029171932488679886,
-0.06929784268140793,
-0.01077992282807827,
-0.031167784705758095,
-0.03819968178868294,
-0.04808611422777176,
-0.024019848555326462,
-0.06804463267326355,
-0.010054685175418854,
0.01337917149066925,
0.008151663467288017,
-0.02935759350657463,
-0.011133838444948196,
0.008105248212814331,
0.013704078271985054,
-0.0029212546069175005,
0.004122246988117695,
-0.020770788192749023,
0.02615494653582573,
0.01083794143050909,
0.05597669258713722,
-0.011940301395952702,
0.008279305882751942,
-0.0018392009660601616,
0.00829671137034893,
0.03903515636920929,
0.02441437728703022,
-0.009938647970557213,
-0.007043501827865839,
0.020793994888663292,
0.012926624156534672,
0.009573128074407578,
-0.012903416529297829,
0.03198004886507988,
0.0015273491153493524,
-0.048132527619600296,
0.012091151438653469,
-0.052959706634283066,
-0.0038292512763291597,
-0.03474175184965134,
0.043050069361925125,
-0.01029256358742714,
0.002880641259253025,
0.03715534135699272,
0.011870679445564747,
-0.003231656039133668,
-0.01022294070571661,
-0.01971484161913395,
-0.034997034817934036,
-0.02180352434515953,
0.061128776520490646,
0.010652280412614346,
0.03634307533502579,
-0.03383665531873703,
0.014783230610191822,
0.0013931802241131663,
0.00002291295641043689,
-0.05750839039683342,
0.020237013697624207,
0.01822955720126629,
-0.03987062722444534,
0.015421438962221146,
-0.027292117476463318,
-0.025992494076490402,
-0.013692473992705345,
-0.022998714819550514,
-0.011893886141479015,
-0.03163193538784981,
-0.024692868813872337,
0.01807870715856552,
0.0015171957202255726,
0.06187141686677933,
-0.013738889247179031,
-0.0007223360589705408,
0.01835719868540764,
0.048039697110652924,
-0.043931957334280014,
-0.04298044368624687,
-0.00728137930855155,
0.0033680004999041557,
-0.06586312502622604,
0.008644824847579002,
-0.023010319098830223,
0.0011632801033556461,
0.001327183679677546,
-0.014678796753287315,
-0.01537502370774746,
0.03158552199602127,
0.0487823411822319,
0.025319473817944527,
-0.044535353779792786,
-0.008145862258970737,
-0.027361741289496422,
-0.037248171865940094,
0.05449140444397926,
-0.030262688174843788,
-0.054352160543203354,
-0.04910724610090256,
0.00530003197491169,
-0.03801402077078819,
0.021408995613455772,
0.02798834629356861,
0.022105222567915916,
0.016802290454506874,
0.02392701804637909,
0.053841594606637955,
-0.023602113127708435,
-0.05282045900821686,
0.006846236996352673,
-0.015502666123211384,
0.014179833233356476,
0.009254024364054203,
0.019146256148815155,
-0.009648553095757961,
-0.0014787581749260426,
0.01906502991914749,
-0.009474496357142925,
0.0007448183605447412,
-0.017568141222000122,
-0.01586238294839859,
-0.0029502641409635544,
0.016454176977276802,
-0.016674648970365524,
0.009219212457537651,
0.005172390025109053,
-0.02427513152360916,
-0.015688326209783554,
-0.021594656631350517,
-0.018925784155726433,
-0.026967212557792664,
-0.03455609083175659,
-0.023091545328497887,
0.022987112402915955,
-0.00687524676322937,
0.027315326035022736,
-0.01610606350004673,
-0.042934030294418335,
0.041704028844833374,
-0.008157465606927872,
-0.006527132820338011,
-0.04325893521308899,
0.06136085093021393,
0.02724570222198963,
0.028290044516324997,
-0.05848310887813568,
0.0004652395145967603,
0.019262295216321945,
-0.006155811715871096,
-0.01723163016140461,
0.028800610452890396,
-0.05189215764403343,
-0.016535403206944466,
-0.03344212844967842,
-0.013796908780932426,
-0.021849939599633217,
-0.03666798025369644,
-0.010182327590882778,
0.01943635195493698,
-0.022604186087846756,
0.0017753801075741649,
-0.025365889072418213,
0.02093324065208435,
-0.04822535812854767,
0.022905884310603142,
-0.053841594606637955,
0.0859144777059555,
-0.029960989952087402,
0.018786538392305374,
-0.008331522345542908,
-0.007107322569936514,
-0.03952251374721527,
0.03230495750904083,
0.02043427713215351,
0.019761256873607635,
0.016535403206944466,
-0.0646563246846199,
0.044024787843227386,
0.01058845967054367,
-0.0011922896374017,
0.00350144412368536,
0.03158552199602127,
0.011905490420758724,
0.026247777044773102,
0.013054265640676022,
0.02032984234392643,
0.033650998026132584,
0.027593817561864853,
0.00505055021494627,
0.01339077576994896,
-0.01821795292198658,
-0.06437783688306808,
-0.008145862258970737,
-0.007844163104891777,
0.010565252043306828,
-0.0010465169325470924,
-0.0428876131772995,
0.017533330246806145,
0.03659835830330849,
0.05514121800661087,
-0.015386627987027168,
0.04502271115779877,
-0.05268121510744095,
-0.039963457733392715,
-0.024716077372431755,
0.01820634864270687,
0.03831572085618973,
0.011435536667704582,
-0.041611198335886,
0.028522120788693428,
0.000721610791515559,
0.024066263809800148,
0.019912106916308403,
-0.0016622431576251984,
0.04599742963910103,
-0.010629073716700077,
0.009149589575827122,
-0.027570609003305435,
-0.01650059223175049,
-0.0025397799909114838,
0.03952251374721527,
-0.026108531281352043,
-0.049014415591955185,
0.0038408550899475813,
0.015897193923592567,
-0.017881443724036217,
0.004690832924097776,
0.008691240102052689,
-0.033395711332559586,
0.07872012257575989,
-0.02378777228295803,
0.05602310597896576,
0.031771183013916016,
0.009306240826845169,
-0.01599002443253994,
-0.028081176802515984,
-0.0039655957370996475,
-0.05323819816112518,
0.017498517408967018,
-0.013831719756126404,
0.053470272570848465,
-0.010072091594338417,
-0.008145862258970737,
-0.018624085932970047,
0.001769578200764954,
-0.009677561931312084,
0.024205509573221207,
0.05801896005868912,
-0.02455362305045128,
-0.00860421173274517,
-0.03931364789605141,
0.03966176137328148,
-0.01983088068664074,
-0.01394775789231062,
0.03395269438624382,
-0.02910231053829193,
0.03467212989926338,
-0.01170242391526699,
0.009149589575827122,
-0.012416057288646698,
0.039847422391176224,
0.003394109196960926,
-0.008569399826228619,
-0.0513351745903492,
-0.019656823948025703,
0.0763065367937088,
-0.006956472992897034,
-0.014736815355718136,
-0.01747531071305275,
0.0391744002699852,
-0.029821744188666344,
0.026178155094385147,
-0.04226100817322731,
0.01959880441427231,
-0.04971064254641533,
-0.008633221499621868,
0.020910032093524933,
-0.027361741289496422,
-0.014899268746376038,
-0.005392862018197775,
0.023834187537431717,
0.01609445922076702,
-0.020747579634189606,
-0.018426820635795593,
-0.00885369349271059,
-0.013762096874415874,
0.0034927413798868656,
0.029891368001699448,
-0.023729754611849785,
0.0009058209834620357,
0.030193066224455833,
-0.034509677439928055,
0.0035420574713498354,
0.011685018427670002,
0.06006122753024101,
-0.03601817041635513,
0.012915019877254963,
-0.05379517748951912,
-0.020144183188676834,
0.03360458090901375,
0.02777947671711445,
-0.0028400281444191933,
0.029427215456962585,
-0.04098459333181381,
0.004403639119118452,
0.015317005105316639,
0.003910477738827467,
0.006794020067900419,
-0.018380405381321907,
0.028197214007377625,
-0.01250888779759407,
0.019668426364660263,
0.017173612490296364,
0.030912501737475395,
0.018542859703302383,
-0.025969285517930984,
-0.021629467606544495,
-0.006857840809971094,
0.00991544034332037,
0.023950226604938507,
-0.04114704579114914,
0.03903515636920929,
-0.0037683313712477684,
0.03321005031466484,
-0.00916119385510683,
-0.007513455115258694,
0.027199288830161095,
-0.009787797927856445,
-0.020759183913469315,
-0.026062116026878357,
0.024948151782155037,
-0.021989185363054276,
-0.001769578200764954,
-0.0005841783713549376,
0.0012720656814053655,
0.002779108239337802,
0.0046966345980763435,
-0.013692473992705345,
0.04859668016433716,
0.03160873055458069,
0.016082854941487312,
0.04597422480583191,
-0.00202921312302351,
0.05170649662613869,
-0.009300438687205315,
-0.028800610452890396,
0.03144627436995506,
0.011197659187018871,
-0.025087397545576096,
-0.00973558146506548,
-0.04548686370253563,
-0.003991704434156418,
0.014527947641909122,
-0.0035130479373037815,
-0.01184166967868805,
-0.017637763172388077,
-0.01518936362117529,
0.028545327484607697,
0.007490247488021851,
-0.019146256148815155,
-0.04462818428874016,
-0.0173476692289114,
-0.01908823661506176,
-0.017904650419950485,
-0.0041570584289729595,
-0.008105248212814331,
0.00301988678984344,
0.013019454665482044,
-0.0020640245638787746,
-0.013692473992705345,
-0.05203140154480934,
0.026711929589509964,
-0.0038350531831383705,
-0.04734347015619278,
0.01058265846222639,
-0.02715287357568741,
-0.0006824479787610471,
-0.009213410317897797,
0.017266442999243736,
0.021722298115491867,
0.008737655356526375,
-0.025203436613082886,
0.03163193538784981,
-0.030703632161021233,
0.011667612940073013,
-0.025133812800049782,
0.020863616839051247,
-0.015456250868737698,
0.039244022220373154,
-0.014527947641909122,
-0.014609173871576786,
-0.02092163637280464,
-0.008615815080702305,
-0.017568141222000122,
-0.04221459478139877,
-0.020805599167943,
0.0063878875225782394,
-0.033511750400066376,
-0.011133838444948196,
0.022720225155353546,
0.0031272219493985176,
-0.030564388260245323,
-0.05323819816112518,
0.04729705676436424,
0.004139652941375971,
-0.004487766418606043,
0.003936586435884237,
0.0007042051292955875,
0.034022316336631775,
0.02107248641550541,
-0.010234544053673744,
0.004017813131213188,
-0.016013232991099358,
0.010066289454698563,
-0.0448138453066349,
-0.004334016237407923,
-0.0029676698613911867,
0.06409934908151627,
-0.01572313718497753,
0.009752986952662468,
-0.02364852838218212,
-0.0011436986969783902,
-0.0033592977561056614,
0.0033825053833425045,
0.02094484493136406,
-0.01673266850411892,
0.04240025579929352,
0.005993358325213194,
-0.01683710142970085,
0.02118852362036705,
0.005468287039548159,
-0.01351841725409031,
-0.008279305882751942,
-0.02327720634639263,
0.02229088358581066,
-0.01623370498418808,
-0.011835867539048195,
-0.029914574697613716,
-0.035762887448072433,
0.017811819911003113,
0.0016898021567612886,
-0.03518269583582878,
-0.008905909955501556,
0.01945955865085125,
0.05054611712694168,
0.03207287937402725,
-0.036853641271591187,
0.009323646314442158,
0.008325720205903053,
0.016129270195961,
-0.015212571248412132,
-0.00948609970510006,
-0.0029850753489881754,
-0.015676721930503845,
-0.0341847687959671,
-0.009085768833756447,
-0.012369642034173012,
0.0035420574713498354,
0.011963509023189545,
-0.032792314887046814,
-0.03383665531873703,
0.000027332369427313097,
0.01624530926346779,
0.00458929967135191,
-0.005688759032636881,
-0.03235137090086937,
-0.01413341797888279,
0.0394296832382679,
-0.017904650419950485,
-0.04780762270092964,
0.013622851110994816,
-0.017045971006155014,
-0.010826338082551956,
0.007414822932332754,
-0.00972397718578577,
0.014063796028494835,
-0.000822418718598783,
-0.012172377668321133,
0.004363025538623333,
0.006608359515666962,
-0.010866951197385788,
0.0011509511386975646,
0.0013010750990360975,
-0.017660971730947495,
-0.0017942363629117608,
-0.011539970524609089,
0.03875666484236717,
-0.00990383606404066,
0.0193319171667099,
-0.0004692283400800079,
0.040195535868406296,
-0.013530021533370018,
0.03130703046917915,
0.05291328951716423,
-0.03826930373907089,
0.035739678889513016,
-0.007751333061605692,
0.011186054907739162,
-0.012265208177268505,
0.0023642724845558405,
-0.015932006761431694,
0.016407761722803116,
0.01351841725409031,
-0.0006672180024906993,
0.08647145330905914,
-0.007345200050622225,
0.02019059844315052,
0.013564832508563995,
0.012729359790682793,
0.026363814249634743,
0.016512196511030197,
-0.012427660636603832,
-0.026804758235812187,
0.008314116857945919,
-0.01683710142970085,
0.009085768833756447,
-0.017057573422789574,
-0.05091743916273117,
-0.0008898657979443669,
0.01276417076587677,
0.005044748540967703,
-0.0011241172906011343,
-0.0006817227695137262,
-0.0021713594906032085,
0.010669686831533909,
-0.029659291729331017,
-0.013042662292718887,
-0.020295031368732452,
0.014887664467096329,
0.006463312078267336,
-0.011870679445564747,
-0.009654355235397816,
-0.02889344096183777,
-0.029427215456962585,
0.015108136460185051,
0.010716102086007595,
0.03852459043264389,
-0.03230495750904083,
0.03857100382447243,
-0.00659675570204854,
-0.007246567867696285,
0.0008550544152967632,
0.006161613389849663,
0.030425142496824265,
0.016280120238661766,
0.0029937783256173134,
-0.026688721030950546,
-0.008087842725217342,
-0.0014707805821672082,
0.029195141047239304,
-0.021258147433400154,
0.05063894763588905,
0.005935339722782373,
0.018902577459812164,
-0.002023411216214299,
0.007977606728672981,
-0.025574756786227226,
-0.0006965901120565832,
0.042678747326135635,
0.014760022982954979,
-0.020120974630117416,
0.03875666484236717,
-0.006463312078267336,
-0.0053609516471624374,
0.008093644864857197,
-0.016790686175227165,
-0.03903515636920929,
-0.017753802239894867,
-0.030285896733403206,
0.02453041635453701,
-0.004856186918914318,
-0.0023686240892857313,
-0.007374209817498922,
0.001990050310268998,
0.02453041635453701,
-0.022116826847195625,
-0.029798537492752075,
-0.008232890628278255,
-0.01337917149066925,
0.03385986387729645,
0.017011158168315887,
-0.0015186462551355362,
-0.013924550265073776,
0.0033738024067133665,
0.0016999555518850684,
0.007849965244531631,
-0.023126356303691864,
-0.004699535667896271,
-0.009016145952045918,
-0.025690795853734016,
0.002764603355899453,
0.02715287357568741,
-0.029798537492752075,
-0.02142059989273548,
0.0036087792832404375,
-0.008697042241692543,
-0.01029256358742714,
-0.002345416462048888,
-0.036621566861867905,
0.03218891844153404,
0.03023948147892952,
0.019041823223233223,
-0.0028313251677900553,
0.01165020652115345,
-0.016384553164243698,
-0.020968051627278328,
-0.002095934934914112,
-0.021989185363054276,
-0.009248222224414349,
0.024623246863484383,
-0.04910724610090256,
-0.009190202690660954,
-0.03669118881225586,
0.012392849661409855,
0.011893886141479015,
-0.0005932438652962446,
-0.009097373113036156,
0.018415218219161034,
-0.002274343278259039,
-0.0067766145803034306,
0.006469113752245903,
0.016326535493135452,
-0.00697387894615531,
-0.00923661794513464,
-0.0016230803448706865,
0.04734347015619278,
-0.02661909908056259,
0.02056191861629486,
-0.0018812647322192788,
0.041471950709819794,
0.04757554456591606,
-0.10424846410751343,
-0.019366728141903877,
0.010988790541887283,
-0.037967607378959656,
-0.03532194346189499,
0.007832559756934643,
-0.007339398376643658,
-0.011621197685599327,
-0.00023515809152740985,
-0.02824362926185131,
0.0022961003705859184,
-0.026479853317141533,
0.016036439687013626,
0.01382011640816927,
-0.016442572697997093,
-0.02924155443906784,
-0.025969285517930984,
-0.054816313087940216,
0.00753086106851697,
0.02550513483583927,
-0.022372109815478325,
0.00768751185387373,
0.0010798778384923935,
0.04562610760331154,
-0.018043896183371544,
0.022093620151281357,
-0.020643144845962524,
-0.00027722184313461185,
-0.033395711332559586,
-0.049896303564310074,
0.0016578917857259512,
0.024367962032556534,
-0.017185214906930923,
0.04383912682533264,
-0.038733456283807755,
-0.044280070811510086,
0.03471854329109192,
0.004072931129485369,
0.0024890133645385504,
-0.0018377505475655198,
0.010919167660176754,
-0.005865716841071844,
0.019726445898413658,
0.008041427470743656,
-0.028336459770798683,
-0.023381641134619713,
-0.0288702342659235,
0.00601076427847147,
-0.0027486481703817844,
-0.016929931938648224,
0.011122234165668488,
-0.03882628679275513,
-0.041448745876550674,
0.017742197960615158,
0.006080386694520712,
-0.03404552489519119,
-0.02281305380165577,
0.0357164703309536,
-0.005059253424406052,
0.019622011110186577,
-0.05425933003425598,
0.0431428961455822,
0.02761702425777912,
-0.0013141294475644827,
-0.013123888522386551,
0.00010951078729704022,
-0.02439117059111595,
0.013483606278896332,
-0.023950226604938507,
0.02601570077240467,
0.003852458903566003,
-0.004658922553062439,
-0.032165709882974625,
0.019970126450061798,
0.035762887448072433,
-0.007316190749406815,
-0.004879394546151161,
0.025806833058595657,
-0.0025760417338460684,
0.004012010991573334,
0.005813499912619591,
-0.005993358325213194,
-0.005610433407127857,
-0.0035130479373037815,
-0.020979655906558037,
-0.007449634373188019,
-0.02552834153175354,
0.017162008211016655,
0.004983828403055668,
0.002265640301629901,
-0.0010951078729704022,
-0.021153712645173073,
-0.01636134646832943,
0.011574782431125641,
0.00026326102670282125,
-0.027825891971588135,
-0.030541179701685905,
-0.020596729591488838,
0.01537502370774746,
-0.01625691168010235,
0.05625518411397934,
-0.023370036855340004,
-0.02256937511265278,
-0.013982568867504597,
-0.03409194201231003,
0.00862161722034216,
0.029682500287890434,
0.009021948091685772,
0.01585077866911888,
-0.039940252900123596,
0.02317277155816555,
-0.0013648959575220942,
0.019018614664673805,
-0.026433438062667847,
-0.011354310438036919,
0.0021670081187039614,
0.021234938874840736,
-0.02678155153989792,
0.0003038742870558053,
-0.0015171957202255726,
0.04984989017248154,
0.008592607453465462,
0.007844163104891777,
-0.011360112577676773,
0.027849100530147552,
-0.023451263085007668,
-0.016280120238661766,
0.03966176137328148,
-0.028081176802515984,
0.014864456839859486,
0.01380851212888956,
0.015920402482151985,
-0.006550340447574854,
-0.0040526241064071655,
-0.02104927785694599,
0.048875171691179276,
0.002880641259253025,
0.03137665241956711,
-0.020480692386627197,
0.026456644758582115,
-0.011290489695966244,
-0.01994691789150238,
-0.012996247038245201,
0.0011480501852929592,
0.011377518065273762,
-0.03274590149521828,
-0.0428876131772995,
-0.007409021258354187,
0.009944449178874493,
-0.009085768833756447,
-0.0314926914870739,
0.010106902569532394,
0.06878727674484253,
0.05982914939522743,
-0.008128455840051174,
0.0453244112432003,
0.008000814355909824,
-0.01214917004108429,
-0.011870679445564747,
0.027709854766726494,
-0.03483458235859871,
0.06725557893514633,
-0.021896354854106903,
-0.03645911440253258,
0.0016216299263760448,
-0.03311722353100777,
-0.01560709998011589,
-0.008824683725833893,
0.031515900045633316,
0.005517602898180485,
0.019645219668745995,
-0.06883369386196136,
0.033256467431783676,
-0.00558142364025116,
-0.03321005031466484,
0.02975212223827839,
0.028104383498430252,
-0.000697677955031395,
0.031190993264317513,
0.04683290421962738,
-0.0128337936475873,
0.010832139290869236,
0.0036522934678941965,
0.01673266850411892,
0.023230791091918945,
-0.02750098705291748,
0.00514628179371357,
-0.033395711332559586,
0.03035551868379116,
-0.0073800114914774895,
-0.01058265846222639,
-0.018774935975670815,
0.004676328040659428,
0.04047402739524841,
0.04539403319358826,
0.008256098255515099,
-0.0265030600130558,
0.03532194346189499,
-0.03819968178868294,
-0.03406873345375061,
-0.05240272358059883,
0.004731446038931608,
0.029914574697613716,
-0.03170155733823776,
-0.019239086657762527,
0.016929931938648224,
0.02019059844315052,
-0.05685858055949211,
-0.022256072610616684,
0.04448893666267395,
-0.020120974630117416,
0.02752419374883175,
-0.0115225650370121,
0.009636948816478252,
0.03613420948386192,
0.0016027737874537706,
-0.010466620326042175,
0.014481532387435436,
-0.021907959133386612,
-0.0016883517382666469,
-0.027361741289496422,
-0.03269948437809944,
-0.005561117082834244,
-0.005288428161293268,
-0.000658877776004374,
-0.0014127616304904222,
0.03615741431713104,
0.03095891699194908,
-0.011348508298397064,
0.019970126450061798,
-0.012798982672393322,
0.01720842346549034,
0.003188141854479909,
0.023625319823622704,
-0.002201819559559226,
0.020353050902485847,
-0.04014911875128746,
-0.028290044516324997,
0.003504345193505287,
-0.008232890628278255,
0.05908650904893875,
0.019169464707374573,
-0.012102754786610603,
-0.041704028844833374,
-0.007629493251442909,
-0.00576128251850605,
0.059040091931819916,
-0.04432648420333862,
-0.016547007486224174,
-0.02615494653582573,
0.0031040143221616745,
0.003481137566268444,
0.028777403756976128,
0.024135887622833252,
0.03211929649114609,
0.003904675832018256,
0.0013627202715724707,
0.00055806984892115,
0.024484001100063324,
0.013831719756126404,
0.010367987677454948,
-0.006161613389849663,
0.0014541001291945577,
0.002990877255797386,
0.039847422391176224,
-0.00007397417357424274,
0.00034902029437944293,
-0.017695782706141472,
0.0036145811900496483,
0.00817487109452486,
0.011632801033556461,
0.0014533749781548977,
-0.027709854766726494,
0.003208448411896825,
0.022894281893968582,
-0.029171932488679886,
0.012056339532136917,
-0.0034550291020423174,
-0.00418606773018837,
-0.011586385779082775,
-0.006428500637412071,
0.01994691789150238,
-0.028823819011449814,
-0.00001640848677197937,
0.019645219668745995,
0.02801155298948288,
-0.00631826464086771,
-0.017312858253717422,
0.01759134791791439,
-0.036111000925302505,
-0.035275526344776154,
-0.017811819911003113,
-0.003275170223787427,
-0.013297945261001587,
-0.0064575099386274815,
-0.04000987485051155,
-0.007496049627661705,
-0.014852853491902351,
0.0024121382739394903,
-0.016790686175227165,
-0.01870531216263771,
0.04103100672364235,
-0.010739309713244438,
-0.025481926277279854,
0.019018614664673805,
-0.03629666194319725,
-0.005027342587709427,
-0.02193116582930088,
0.06154651194810867,
-0.01407539937645197,
-0.029566461220383644,
0.026549475267529488,
0.035113073885440826,
-0.014574362896382809,
0.016535403206944466,
0.013657663017511368,
0.010141714476048946,
0.03831572085618973,
0.018403613939881325,
0.0016375851118937135,
-0.012102754786610603,
0.018403613939881325,
0.014249456115067005,
-0.004598002415150404,
-0.022720225155353546,
-0.008070437237620354,
0.007124728057533503,
-0.020840410143136978,
-0.004571894183754921,
-0.036876849830150604,
0.02045748569071293,
-0.012091151438653469,
0.014794834889471531,
-0.009120580740272999,
0.011754641309380531,
0.014121814630925655,
-0.01695314049720764,
-0.008569399826228619,
0.01463238149881363,
-0.0006295057246461511,
-0.01596681773662567,
0.0019320313585922122,
0.011725631542503834,
0.00048699663602747023,
0.004946116358041763,
-0.001692703110165894,
-0.013100680895149708,
0.00003746302172658034,
-0.03000740520656109,
-0.018867764621973038,
0.04957139864563942,
-0.024832114577293396,
-0.027222495526075363,
0.03715534135699272,
0.019529182463884354,
0.0011146892793476582,
-0.00197989703156054,
-0.006677982397377491,
0.025180228054523468,
-0.016442572697997093,
-0.007681710179895163,
0.022232865914702415,
0.022023996338248253,
-0.02254616655409336,
-0.010391195304691792,
0.0071015204302966595,
-0.024600038304924965,
0.006985482759773731,
-0.0004971499438397586,
0.007223360240459442,
0.005236211232841015,
0.027941931039094925,
-0.037108927965164185,
0.00037385965697467327,
-0.006382085382938385,
0.021907959133386612,
0.0683695375919342,
0.002342515392228961,
-0.0021510529331862926,
0.043560635298490524,
0.011928698047995567,
-0.024066263809800148,
-0.01735927164554596,
-0.016384553164243698,
-0.02005135267972946,
-0.02615494653582573,
-0.030773255974054337,
-0.024019848555326462,
0.021594656631350517,
-0.0014403206296265125,
-0.008882702328264713,
-0.0167094599455595,
0.01724323444068432,
0.003678401932120323,
-0.013437191024422646,
0.000523983733728528,
-0.006550340447574854,
0.023578904569149017,
-0.013994173146784306,
0.006515529006719589,
-0.030634010210633278,
-0.01906502991914749,
0.019285501912236214,
0.002568789292126894,
0.011516762897372246,
0.01846163347363472,
0.022372109815478325,
0.04325893521308899,
0.018902577459812164,
0.013901342637836933,
-0.004920007660984993,
0.013274737633764744,
-0.05746197700500488,
0.02947363071143627,
-0.010426007211208344,
-0.014400305226445198,
-0.0038727654609829187,
-0.024135887622833252,
-0.02527305856347084,
-0.014609173871576786,
0.006271849386394024,
-0.018658896908164024,
0.010008270852267742,
-0.005975952837616205,
-0.0007803550106473267,
0.01683710142970085,
0.017765404656529427,
-0.007496049627661705,
-0.02429834008216858,
0.023741358891129494,
0.0063936891965568066,
-0.0024600038304924965,
-0.012056339532136917,
-0.009335250593721867,
-0.05463065207004547,
0.00753086106851697,
-0.01276417076587677,
0.0006577899330295622,
-0.031655143946409225,
0.004835880361497402,
0.00015130256360862404,
-0.006260245572775602,
0.05017479509115219,
0.02429834008216858,
0.013657663017511368,
-0.02032984234392643,
-0.007211756426841021,
-0.011534169316291809,
-0.010367987677454948,
0.024089472368359566,
0.019726445898413658,
0.030262688174843788,
-0.02427513152360916,
-0.007913785986602306,
-0.03126061335206032,
0.02764023281633854,
-0.04915366321802139,
-0.011621197685599327,
0.03645911440253258,
0.014899268746376038,
-0.030680425465106964,
-0.028034761548042297,
0.0023106050211936235,
0.023393243551254272,
0.010698695667088032,
0.014319078996777534,
-0.019749654456973076,
0.01004308182746172,
-0.025203436613082886,
-0.01672106422483921,
0.0039655957370996475,
0.029218347743153572,
0.028220422565937042,
-0.0028356765396893024,
0.00700288824737072,
-0.027825891971588135,
0.023393243551254272,
0.015084929764270782,
0.02207041159272194,
-0.013274737633764744,
-0.03643590584397316,
0.020643144845962524,
0.0034115146845579147,
-0.015815967693924904,
0.006179019343107939,
0.014203040860593319,
-0.013228322379291058,
-0.011870679445564747,
0.03768911585211754,
-0.0003890896332450211,
0.0043920353055000305,
-0.004275997169315815,
-0.013239926658570766,
-0.018508048728108406,
-0.035623639822006226,
-0.015282194130122662,
-0.004731446038931608,
-0.018763331696391106,
-0.01908823661506176,
0.009149589575827122,
-0.011029403656721115,
0.013413983397185802,
0.01919267140328884,
-0.015212571248412132,
0.012009924277663231,
-0.003486939473077655,
-0.04845743626356125,
-0.05425933003425598,
-0.0053290412761271,
0.02798834629356861,
-0.03274590149521828,
0.008221286348998547,
-0.015026910230517387,
0.010948177427053452,
0.026967212557792664,
-0.015641910955309868,
0.005256517790257931,
0.043699879199266434,
0.021617863327264786,
-0.029705706983804703,
0.027965137735009193,
0.010774120688438416,
0.01797427423298359,
-0.037480246275663376,
-0.020039748400449753,
-0.024019848555326462,
0.014934079721570015,
0.004168662242591381,
-0.0193319171667099,
0.01413341797888279,
0.04253949970006943,
-0.00175072206184268,
0.018890973180532455,
0.004484865348786116,
-0.00011966410238528624,
0.02638702280819416,
-0.022476544603705406,
-0.0010356383863836527,
0.004220879171043634,
-0.0011611044174060225,
-0.04091497138142586,
0.018009085208177567,
0.041564781218767166,
-0.0017666772473603487,
0.019900502637028694,
0.028823819011449814,
0.035275526344776154,
-0.027663439512252808,
-0.03262986242771149,
0.03072684071958065,
0.04509233310818672,
-0.02775627002120018,
0.00903355237096548,
-0.01002567633986473,
-0.04817894473671913,
-0.02218645066022873,
0.007664304692298174,
0.003092410508543253,
-0.024460792541503906,
0.003225854132324457,
0.009781996719539165,
0.003530453657731414,
0.029960989952087402,
-0.005561117082834244,
-0.004539983347058296,
0.0004322412423789501,
0.006184821017086506,
-0.0009754437487572432,
-0.01660502515733242,
0.008697042241692543,
-0.027477778494358063,
-0.008331522345542908,
-0.02291748858988285,
0.010362186469137669,
-0.02603890933096409,
0.04154157638549805,
-0.004444252233952284,
-0.009874827228486538,
0.012740963138639927,
-0.014725212007761002,
0.000697677955031395,
0.012938227504491806,
-0.023010319098830223,
0.0213161651045084,
-0.0005395763437263668,
-0.023242395371198654,
-0.009590533562004566,
-0.017510121688246727,
0.00032291177194565535,
-0.003530453657731414,
-0.05950424447655678,
-0.014852853491902351,
0.03987062722444534,
0.0070144920609891415,
0.006538736633956432,
0.012601718306541443,
0.003547859378159046,
-0.010832139290869236,
-0.04841101914644241,
0.002654367359355092,
-0.00959633570164442,
0.033140428364276886,
-0.004824276547878981,
-0.01993531361222267,
0.0011183153837919235,
-0.00941647682338953,
0.02145541086792946,
-0.03690005838871002,
-0.042678747326135635,
0.005566919222474098,
-0.029450424015522003,
0.014760022982954979,
0.0013576436322182417,
-0.015444646589457989,
-0.01609445922076702,
0.015398231334984303,
-0.04323572665452957,
0.0063066608272492886,
0.01393615361303091,
-0.001169082010164857,
0.010739309713244438,
0.03318684548139572,
-0.01072770543396473,
-0.000548279145732522,
-0.036366283893585205,
0.02366013079881668,
-0.021513430401682854,
0.005160786211490631,
0.037108927965164185,
0.001308327540755272,
-0.003826350439339876,
0.03221212700009346,
0.012845397926867008,
-0.032769106328487396,
0.011986716650426388,
-0.02303352579474449,
-0.012033131904900074,
0.005796093959361315,
-0.03135344386100769,
0.020770788192749023,
0.018032291904091835,
0.0037915389984846115,
-0.00009446212061448023,
0.03404552489519119,
-0.04149515926837921,
0.004246987868100405,
-0.0006864368333481252,
-0.02480890601873398,
0.013970965519547462,
-0.015781156718730927,
-0.02441437728703022,
-0.006312462966889143,
0.013274737633764744,
0.002072727307677269,
0.01980767212808132,
0.012369642034173012,
-0.015166155993938446,
0.015026910230517387,
-0.0344400554895401,
0.0006291430909186602,
0.007095718756318092,
-0.000024635393856442533,
-0.01022294070571661,
0.013692473992705345,
0.04163440316915512,
0.010118506848812103,
0.057740468531847,
0.013634455390274525,
-0.00175072206184268,
-0.010733507573604584,
-0.018287576735019684,
-0.011093225330114365,
-0.011220866814255714,
-0.01981927640736103,
0.09464052319526672,
-0.01164440531283617,
-0.008215484209358692,
-0.008082040585577488,
0.01708078198134899,
-0.025481926277279854,
0.005755480844527483,
0.003312882501631975,
0.01276417076587677,
-0.014203040860593319,
0.02826683595776558,
0.03086608648300171,
0.03047155775129795,
0.036227036267519,
0.04383912682533264,
-0.021791920065879822,
0.01547945849597454,
0.034764960408210754,
0.0025165723636746407,
-0.00601076427847147,
0.02032984234392643,
0.01560709998011589,
-0.016767479479312897,
0.03390628099441528,
-0.011801056563854218,
0.0035884727258235216,
0.0001535689370939508,
-0.0021670081187039614,
0.0023700743913650513,
-0.03137665241956711,
0.014841250143945217,
-0.01795106567442417,
0.04300365224480629,
-0.01072770543396473,
0.0009101724135689437,
-0.023149564862251282,
-0.008389541879296303,
-0.020120974630117416,
0.008952325209975243,
0.028963064774870872,
-0.02081720158457756,
0.009816807694733143,
-0.00334769394248724,
0.011986716650426388,
0.0030314906034618616,
0.0023584705777466297,
-0.013854927383363247,
0.007594681810587645,
0.013530021533370018,
-0.03569326177239418,
0.0017347668763250113,
-0.014261060394346714,
-0.0015026910696178675,
-0.023880602791905403,
-0.028475705534219742,
-0.013332757167518139,
0.024066263809800148,
-0.006399491336196661,
0.022244468331336975,
-0.03824609890580177,
-0.020770788192749023,
0.039847422391176224,
0.019424747675657272,
0.003385406220331788,
-0.0003453941026236862
] | 2024-07-02 | 32 | 38953027 | [
"engineered T cells",
"solid tumor treatment",
"solid tumors",
"immune cells",
"fewer immune cells",
"targeted immunological active cells",
"various tumors",
"tumor microenvironment",
"hematological tumors",
"anti-PD-1 monoclonal antibody",
"corresponding antibody",
"antibody doses",
"profound anti-tumor effects",
"armored T-cells",
"armored-T cell",
"armored-T cells",
"CAR-T cells",
"cancer treatment",
"clinical efficacy",
"limited clinical benefits",
"TME",
"most mAbs",
"synergistic efficacy",
"safety profiles",
"remarkable success",
"metabolic aggressiveness",
"Chimeric antigen receptor T (CAR-T) cell therapies",
"mAbs",
"mAb",
"synergistically produced antibody-dependent cellular cytotoxicity"
] | [
"ADCC",
"CAR-T",
"FcγRI",
"monoclonal antibodies",
"solid tumors"
] | 0 | 10.3389/fimmu.2024.1400177
10.1186/s40364-023-00537-x
10.1186/s12943-023-01723-z
10.3389/fimmu.2021.782775
10.1186/s13287-022-02819-x
10.1016/j.cell.2020.03.001
10.3390/cancers15061836
10.1016/j.tranon.2021.101079
10.1186/s40364-023-00482-9
10.3389/fimmu.2014.00520
10.1182/blood-2008-09-179754
10.1016/j.ab.2021.114411
10.3390/ijms22073349
10.1046/j.1365-2567.1999.00884.x
10.3389/fimmu.2023.1100499
10.1186/s12929-021-00709-7
10.1158/2159-8290.CD-21-0407
10.1182/bloodadvances.2022007317
10.1200/JCO.21.01676
10.1016/j.ccell.2019.09.006
10.3892/ol
10.1186/s12951-023-01900-8
10.1038/s41416-018-0341-1
10.3389/fimmu.2017.00457
10.1016/j.ebiom.2022.103941
10.1016/j.celrep.2023.112797
10.1158/0008-5472.CAN-13-1365
10.1158/2326-6066.CIR-22-0423
10.1186/s40364-022-00434-9
10.1158/0008-5472.CAN-08-4597
10.1186/bcr3674
10.1158/2159-8290.CD-22-1276 | [
"Tang",
"Sun",
"Li",
"Yu",
"Meng",
"Zhang",
"Ma",
"Zeng",
"Li",
"Liu",
"Xu",
"Guo"
] | [
"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.",
"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.",
"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.",
"The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, The School of Life Science and Technology, Southeast University, Nanjing, Jiangsu, China.\nDepartment of Research and Development, RegeneCore Biotech Co., Ltd, Nanjing, Jiangsu, China.",
"Department of Research and Development, RegeneCore Biotech Co., Ltd, Nanjing, Jiangsu, China.",
"Department of Research and Development, RegeneCore Biotech Co., Ltd, Nanjing, Jiangsu, China.",
"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.",
"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.",
"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.",
"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.",
"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.",
"Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China."
] | [
"38953027",
"38017494",
"36717905",
"34790207",
"35365241",
"32243795",
"36980723",
"33862524",
"37147740",
"25368619",
"19018092",
"34648807",
"33805888",
"10583607",
"36814926",
"33482842",
"34266984",
"35349631",
"35333600",
"31715131",
"37274466",
"37208748",
"30429531",
"28496440",
"35301179",
"37436890",
"24197131",
"37070661",
"36419115",
"19934333",
"24919843",
"37249512"
] | [] | 9.685039 | 5.29135 |
38951066 | 787 | [Clinical analysis of the correlation between the expression of soluble B cell maturation antigen and the efficacy of chimeric antigen receptor T cell targeting B cell maturation antigen in patients with multiple myeloma]. | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-07-02 | 23 | 38951066 | [] | [
"Chimeric antigen receptor T cell",
"Multiple myeloma",
"Soluble B cell maturation antigen"
] | 0 | 10.3760/cma.j.issn.0253-2727.2023.01.001
10.1182/blood-2009-08-238196
10.1038/leu.2011.196
10.1182/blood-2015-06-653261
10.1182/blood-2016-01-631200
10.1182/blood-2017-05-743203
10.3390/cancers11122024
10.1016/j.ccell.2017.02.002
10.1200/JCO.2018.77.8084
10.1182/blood-2016-04-711903
10.1056/NEJMoa1817226
10.3389/pore.2023.1611171
10.1016/S1470-2045(14)70442-5
10.3389/fimmu.2021.720571
10.1016/j.bbmt.2018.12.758
10.1111/bjh.15116
10.1126/scitranslmed.aaa0984
10.1016/j.ymthe.2017.06.008
10.1038/ncomms8333
10.1038/s41408-021-00505-4
10.1111/j.1365-2141.2012.09241.x
10.3324/haematol.2016.150896
10.1158/1078-0432.CCR-15-2224 | [
"Gao",
"Mu",
"Li",
"Wang",
"Cui",
"Li",
"Sui",
"Deng"
] | [
"Department of Hematology, First Central Hospital of Nankai University, Tianjin 300192, China.",
"Department of Hematology, First Central Hospital of Nankai University, Tianjin 300192, China.",
"Department of Hematology, First Central Hospital of Nankai University, Tianjin 300192, China.",
"Department of Hematology, First Central Hospital of Nankai University, Tianjin 300192, China.",
"Department of Hematology, First Central Hospital of Nankai University, Tianjin 300192, China.",
"Department of Hematology, First Central Hospital of Nankai University, Tianjin 300192, China.",
"Department of Hematology, First Central Hospital of Nankai University, Tianjin 300192, China.",
"Department of Hematology, First Central Hospital of Nankai University, Tianjin 300192, China."
] | [
"38951066",
"20203260",
"21799510",
"26272217",
"27002115",
"28747306",
"31847470",
"28262554",
"29812997",
"27412889",
"31042825",
"37188125",
"25439696",
"34421924",
"30592986",
"29748955",
"28724573",
"28676342",
"26065893",
"34168119",
"22804669",
"28034989",
"26960399"
] | [] | 32.98259 | 7.500974 |
|
38948924 | 788 | Efficacy and safety of bendamustine-containing bridging therapy in R/R LBCL patients receiving CD19 CAR T-cells. | Bridging therapy (BT) after leukapheresis is required in most relapsed/refractory (R/R) large B-cell lymphoma (LBCL) patients receiving chimeric antigen receptor (CAR) T cells. Bendamustine-containing regimens are a potential BT option. We aimed to assess if this agent had a negative impact on CAR-T outcomes when it was administered as BT. We included R/R LBCL patients from six centers who received systemic BT after leukapheresis from February 2019 to September 2022; patients who only received steroids or had pre-apheresis bendamustine exposure were excluded. Patients were divided into two BT groups, with and without bendamustine. Separate safety and efficacy analyses were carried out for axi-cel and tisa-cel. Of 243 patients who received BT, bendamustine (benda) was included in 62 (26%). There was a higher rate of BT progressors in the non-benda group (62% vs. 45%, | [
0.023920772597193718,
0.0103146992623806,
0.052091822028160095,
0.04711588844656944,
-0.04970752075314522,
0.0023438080679625273,
-0.04219178482890129,
0.013955943286418915,
-0.01342465914785862,
0.009660311974585056,
-0.01845242641866207,
0.003352925181388855,
-0.0515475794672966,
0.018918920308351517,
0.023402445018291473,
0.010405406355857849,
0.049914851784706116,
-0.0005361440707929432,
-0.04221770167350769,
0.03382081165909767,
0.03363939747214317,
0.054268792271614075,
0.01850426010787487,
0.011370789259672165,
-0.04942243918776512,
-0.02070714719593525,
0.023246947675943375,
-0.02467234618961811,
-0.005115235690027475,
-0.018024807795882225,
0.01858200877904892,
-0.018283970654010773,
-0.011804888024926186,
-0.007263051345944405,
-0.03081451542675495,
0.035453539341688156,
0.03713810071349144,
0.02463347092270851,
0.0005798778729513288,
-0.03534987196326256,
0.004198445472866297,
0.028274714946746826,
0.028248799964785576,
0.06556831300258636,
-0.07443169504404068,
0.002308173105120659,
0.0057825809344649315,
-0.01873750612139702,
0.02567012421786785,
-0.016119956970214844,
-0.009051278233528137,
-0.003012773348018527,
-0.014655684120953083,
0.0517808273434639,
-0.019333582371473312,
0.013126621022820473,
-0.015083303675055504,
-0.009848205372691154,
0.031151428818702698,
-0.011519808322191238,
0.04563865810632706,
-0.0036347652785480022,
-0.01867271587252617,
-0.01039244793355465,
-0.07614217698574066,
-0.01741577312350273,
-0.04501666501164436,
-0.01229081954807043,
0.01763606257736683,
0.03208441659808159,
-0.008656053803861141,
0.003699555993080139,
0.00981581024825573,
0.018944837152957916,
0.004464087542146444,
0.0026952982880175114,
0.04944835603237152,
0.03895224258303642,
0.014668642543256283,
0.010580341331660748,
0.03268049284815788,
-0.011616994626820087,
0.003280035452917218,
-0.03843391686677933,
-0.003929563332349062,
0.006679933983832598,
-0.0021672530565410852,
-0.010580341331660748,
-0.00021057017147541046,
-0.0013986718840897083,
-0.02284524403512478,
-0.040792301297187805,
-0.05597927048802376,
0.0414920449256897,
0.017014069482684135,
0.020162904635071754,
-0.03397630900144577,
-0.062251023948192596,
0.002334089484065771,
-0.007969271391630173,
0.03166975453495979,
0.019981490448117256,
0.007975750602781773,
0.003855054033920169,
0.06831544637680054,
0.019994448870420456,
-0.012588856741786003,
0.015757128596305847,
0.021225474774837494,
-0.002823260147124529,
0.0717364028096199,
-0.0074250283651053905,
0.006245835218578577,
0.03941873833537102,
-0.006790078245103359,
-0.036671604961156845,
-0.002230424201115966,
-0.029596447944641113,
-0.011040356010198593,
-0.007081637158989906,
-0.008552388288080692,
0.029440950602293015,
0.010645132511854172,
0.010172159411013126,
-0.008558867499232292,
0.01391706895083189,
0.09008516371250153,
-0.03581636771559715,
-0.0009645734098739922,
-0.06629396975040436,
0.034546468406915665,
-0.020357277244329453,
0.055305447429418564,
-0.029440950602293015,
-0.055098116397857666,
-0.009472418576478958,
-0.022378750145435333,
0.006673454772680998,
-0.026512404903769493,
-0.023052575066685677,
0.015174010768532753,
-0.0076258801855146885,
0.007178823463618755,
0.0030694652814418077,
-0.03376897796988487,
0.0030500281136482954,
-0.008513513952493668,
0.02783413790166378,
0.010003703646361828,
-0.004765365272760391,
-0.07909663766622543,
0.031462423503398895,
0.028300631791353226,
0.02272862009704113,
0.01737689971923828,
-0.03322473540902138,
-0.014305814169347286,
0.0516253300011158,
-0.03586820140480995,
-0.03509071096777916,
-0.008999445475637913,
-0.019929656758904457,
-0.007645317353308201,
-0.034779712557792664,
0.046027399599552155,
-0.005717790219932795,
-0.010651611723005772,
0.04758238047361374,
-0.04983710125088692,
-0.0003798362158704549,
0.026149576529860497,
-0.04053314030170441,
-0.04569048807024956,
-0.03695668652653694,
-0.03511662781238556,
0.009841726161539555,
0.0071723442524671555,
0.004972695838660002,
0.010042577981948853,
-0.01952795498073101,
0.0257349144667387,
0.03278415650129318,
0.04926694184541702,
0.0024620513431727886,
-0.0620955266058445,
-0.008487598039209843,
-0.03998889774084091,
0.05675676092505455,
-0.04429100826382637,
-0.004570992663502693,
0.005691873840987682,
-0.002306553302332759,
0.05945206061005592,
0.019294707104563713,
-0.011746576055884361,
-0.00442845281213522,
0.0028621347155421972,
0.01141614280641079,
-0.020253611728549004,
-0.013593114912509918,
0.02287116087973118,
-0.04654572904109955,
-0.024452056735754013,
0.00005147833508090116,
-0.014241022989153862,
-0.0023519068490713835,
-0.00875324010848999,
0.012219549156725407,
-0.004360422492027283,
-0.04460200294852257,
0.02465938776731491,
-0.01089781615883112,
-0.027419475838541985,
0.01762310415506363,
-0.020370235666632652,
-0.00545862689614296,
0.0019080897327512503,
0.04439467191696167,
0.028326548635959625,
0.03319881856441498,
0.033432066440582275,
-0.02977786213159561,
0.023946687579154968,
0.0409996323287487,
-0.02362273447215557,
-0.009938912466168404,
0.013016476295888424,
0.01390411052852869,
-0.01863384060561657,
0.0051541100256145,
-0.005912162829190493,
-0.011545725166797638,
0.006252314429730177,
-0.03179933503270149,
-0.016754906624555588,
-0.017027027904987335,
-0.005957516375929117,
0.013670863583683968,
0.05058867484331131,
-0.050951503217220306,
0.02183450758457184,
-0.008124769665300846,
0.04348760098218918,
-0.026136618107557297,
-0.023454278707504272,
0.004383099265396595,
0.0025559980422258377,
-0.06940393149852753,
0.0204609427601099,
0.023195115849375725,
-0.012984081171452999,
0.01023695059120655,
-0.0259552039206028,
-0.05857090651988983,
-0.014098483137786388,
0.03747501224279404,
0.05660126358270645,
-0.04006664454936981,
-0.002078165765851736,
-0.02262495644390583,
-0.004775083623826504,
-0.024374308064579964,
-0.03172158822417259,
-0.015329509042203426,
-0.07966679334640503,
0.027393560856580734,
-0.0032946134451776743,
0.002829739125445485,
0.0022628195583820343,
0.011591078713536263,
-0.027315812185406685,
0.004166049882769585,
0.034546468406915665,
-0.051158834248781204,
-0.01393002737313509,
-0.005338763818144798,
0.03996298089623451,
-0.004525639116764069,
-0.022197335958480835,
0.027341727167367935,
-0.010340615175664425,
0.03003702685236931,
-0.0021251391153782606,
-0.07857830822467804,
0.009064236655831337,
0.00772954523563385,
0.023246947675943375,
-0.02465938776731491,
0.02674565277993679,
0.010275824926793575,
0.0006341401604004204,
0.019903741776943207,
0.003524620784446597,
-0.04618290066719055,
0.018309887498617172,
0.002926925430074334,
0.04048130661249161,
-0.04299519211053848,
-0.033665310591459274,
0.025177713483572006,
-0.03288782387971878,
0.06878194212913513,
-0.02368752472102642,
-0.005228619556874037,
0.04532765969634056,
0.019787117838859558,
-0.029259536415338516,
-0.0018513977993279696,
-0.0034825068432837725,
0.055305447429418564,
0.017182527109980583,
0.024361349642276764,
-0.009414106607437134,
0.008805072866380215,
-0.013709737919270992,
0.032447244971990585,
-0.0001852612622315064,
-0.053180307149887085,
0.0008924935827963054,
-0.015135136432945728,
-0.04050722345709801,
0.02889670804142952,
-0.031384676694869995,
-0.019359497353434563,
0.048800449818372726,
-0.01846538484096527,
-0.00041425632662139833,
-0.03630877658724785,
0.003718993393704295,
-0.02355794422328472,
0.018750464543700218,
-0.025294337421655655,
0.07531285285949707,
-0.052169572561979294,
0.01451314426958561,
0.007664754521101713,
-0.0027001576963812113,
-0.030710849910974503,
0.021873382851481438,
0.011474454775452614,
0.00012239391799084842,
0.019929656758904457,
0.025164755061268806,
0.012770270928740501,
0.01654757559299469,
0.00876619853079319,
0.013463533483445644,
0.00021421465498860925,
0.01871158927679062,
0.011390226893126965,
0.024983340874314308,
-0.00154526112601161,
0.02697889879345894,
-0.015679379925131798,
0.00935579463839531,
0.04724546894431114,
-0.024141060188412666,
-0.01487597357481718,
-0.00294312322512269,
0.010463718324899673,
-0.00817012321203947,
0.01039244793355465,
-0.04620881378650665,
0.022897077724337578,
0.03845983371138573,
0.05945206061005592,
-0.014396521262824535,
-0.0023697244469076395,
-0.03433913737535477,
-0.060229551047086716,
0.027289895340800285,
-0.016042208299040794,
0.022443542256951332,
0.013968901708722115,
-0.02980377897620201,
0.024076269939541817,
0.052039988338947296,
0.04540541023015976,
0.042917441576719284,
0.011604036204516888,
0.016016291454434395,
-0.031384676694869995,
-0.002755229827016592,
-0.008370974101126194,
-0.005050444509834051,
0.0717882364988327,
0.019981490448117256,
0.024257684126496315,
-0.010139764286577702,
0.02372639998793602,
-0.011208812706172466,
0.020849687978625298,
0.042917441576719284,
-0.04361718147993088,
-0.008720844984054565,
0.08091077953577042,
-0.030451687052845955,
0.07287672162055969,
0.011377268470823765,
0.031540174037218094,
-0.007943354547023773,
-0.017726769670844078,
-0.04843762144446373,
-0.01750648021697998,
0.01838763616979122,
-0.0027228344697505236,
0.002309792907908559,
-0.01748056337237358,
0.028507962822914124,
-0.0517030768096447,
-0.006122733000665903,
0.03382081165909767,
0.025592375546693802,
0.006022307090461254,
0.04353943467140198,
0.012925769202411175,
-0.005730748176574707,
0.10102185606956482,
-0.019825991243124008,
0.06966309249401093,
0.045768238604068756,
0.0050439657643437386,
0.01851721666753292,
-0.03099592961370945,
-0.003955479711294174,
-0.013580156490206718,
0.03268049284815788,
0.004383099265396595,
-0.0000644871179247275,
-0.0015371623449027538,
0.013126621022820473,
0.018854130059480667,
-0.011662348173558712,
-0.016754906624555588,
-0.02379119023680687,
0.031592004001140594,
-0.04413551092147827,
0.023972604423761368,
-0.03921140730381012,
-0.00102855428121984,
-0.01977415941655636,
0.0053646801970899105,
0.021082933992147446,
0.006841911002993584,
-0.007638838142156601,
-0.025229547172784805,
0.02489263378083706,
0.0257867481559515,
-0.024270642548799515,
-0.03218808025121689,
-0.021212516352534294,
-0.028274714946746826,
0.012822103686630726,
-0.017312107607722282,
-0.020435025915503502,
0.007250093389302492,
0.009647353552281857,
-0.07007775455713272,
0.02173084206879139,
0.01872454769909382,
0.0518585741519928,
-0.025242505595088005,
0.012945206835865974,
-0.0259552039206028,
-0.018154388293623924,
0.06090337410569191,
0.039574235677719116,
0.009154943749308586,
-0.02385598048567772,
-0.014474269933998585,
0.029311368241906166,
0.018880046904087067,
-0.045949652791023254,
0.023195115849375725,
0.014694558456540108,
0.023156240582466125,
-0.010800630785524845,
0.015912625938653946,
0.02664198726415634,
-0.011629953049123287,
-0.004464087542146444,
-0.018983710557222366,
-0.016262495890259743,
-0.03312106803059578,
0.02881895937025547,
0.06914477050304413,
0.026447614654898643,
0.004454369191080332,
-0.04719363525509834,
0.015329509042203426,
0.006006109528243542,
-0.002661283127963543,
-0.01645686849951744,
-0.01347649097442627,
0.002737412229180336,
-0.026590153574943542,
0.006783599033951759,
-0.00597371393814683,
0.04750463366508484,
-0.02695298194885254,
-0.005763143766671419,
0.03708626702427864,
0.029596447944641113,
-0.00046649391879327595,
0.042632363736629486,
0.034520551562309265,
-0.03519437462091446,
0.018154388293623924,
-0.030607184395194054,
-0.0004612296761479229,
-0.013580156490206718,
-0.039781566709280014,
0.01853017508983612,
0.003997593652456999,
-0.05442429333925247,
0.001282858313061297,
-0.051988158375024796,
-0.015847835689783096,
-0.018089598044753075,
0.004755646456032991,
-0.030373938381671906,
-0.010003703646361828,
0.014059608802199364,
-0.021458720788359642,
0.023907814174890518,
-0.019825991243124008,
-0.016936320811510086,
-0.04418734088540077,
-0.011714180931448936,
-0.026499446481466293,
0.002149435691535473,
-0.009556646458804607,
0.002821640344336629,
0.024516846984624863,
-0.0204739011824131,
-0.006103295832872391,
-0.01764902099967003,
0.036697521805763245,
0.01766197942197323,
-0.01951499655842781,
-0.03615327924489975,
0.004742688499391079,
0.0038194190710783005,
0.008422806859016418,
-0.002499306108802557,
-0.02980377897620201,
0.02166605181992054,
-0.0102952616289258,
0.017221400514245033,
-0.008034062571823597,
0.03317290171980858,
-0.02565716579556465,
0.022339876741170883,
0.02165309339761734,
0.04395409673452377,
-0.03952240198850632,
-0.00412069633603096,
-0.04887819662690163,
-0.0027795264031738043,
-0.0033124308101832867,
-0.006035265047103167,
-0.028585711494088173,
0.011746576055884361,
-0.030296189710497856,
-0.005348482634872198,
-0.009440023452043533,
0.0059413183480501175,
-0.023143282160162926,
-0.029622364789247513,
0.037630509585142136,
-0.03273232281208038,
0.01742873154580593,
-0.005060163326561451,
-0.03796742111444473,
0.0309700146317482,
-0.02274157851934433,
-0.026564238592982292,
0.02167901024222374,
-0.02253424935042858,
-0.029389116913080215,
-0.023195115849375725,
-0.04452425241470337,
-0.019813034683465958,
0.05603110417723656,
-0.018154388293623924,
0.017312107607722282,
-0.033483896404504776,
-0.05447612330317497,
-0.024115145206451416,
0.016703074797987938,
0.013891153037548065,
0.007567568216472864,
0.06660496443510056,
0.023428361862897873,
0.012634210288524628,
0.0059445579536259174,
0.0032314423006027937,
-0.04618290066719055,
-0.0411551296710968,
0.01504442933946848,
-0.004878749139606953,
-0.02985561080276966,
0.00008777131733950227,
-0.053180307149887085,
-0.00884394720196724,
0.04201037064194679,
0.022974826395511627,
-0.020344318822026253,
0.03286190703511238,
0.03892632573843002,
0.0726175531744957,
0.058208074420690536,
0.025385044515132904,
-0.01751943863928318,
0.037500929087400436,
-0.00221260660327971,
-0.024542763829231262,
-0.02887079119682312,
0.02905220538377762,
-0.017752686515450478,
-0.0014270178508013487,
0.0024231767747551203,
0.01142910122871399,
-0.007774898782372475,
0.019216958433389664,
-0.009543688036501408,
0.023907814174890518,
-0.0103211784735322,
0.046079233288764954,
0.03931507095694542,
-0.030892264097929,
-0.006803036667406559,
0.010100889019668102,
0.057067759335041046,
-0.013968901708722115,
-0.029363201931118965,
0.03599778190255165,
-0.018789339810609818,
-0.04260644689202309,
-0.009530730545520782,
-0.025048132985830307,
-0.001791466260328889,
-0.018167346715927124,
-0.046986304223537445,
0.018076639622449875,
-0.01131895650178194,
-0.05242873355746269,
0.0012593716382980347,
-0.004567753057926893,
-0.01492780540138483,
-0.025527585297822952,
-0.030192524194717407,
0.03475379943847656,
0.017934100702404976,
0.008954091928899288,
-0.028326548635959625,
-0.022041838616132736,
-0.0207719374448061,
0.04004072770476341,
0.048126623034477234,
-0.005060163326561451,
0.010243428871035576,
-0.023506110534071922,
0.014733433723449707,
0.014383562840521336,
0.02154942788183689,
0.007580526173114777,
0.006320344749838114,
0.02464642934501171,
0.003077564062550664,
0.1034579873085022,
0.023182157427072525,
0.005892725195735693,
-0.02990744449198246,
-0.0038906889967620373,
0.007191781420260668,
-0.009096631780266762,
-0.020266570150852203,
-0.012310256250202656,
0.03742317855358124,
-0.007101074326783419,
0.0007394253043457866,
-0.053180307149887085,
-0.04506849870085716,
0.0003093761915806681,
-0.007988709025084972,
0.022132545709609985,
0.007334321271628141,
0.007386154029518366,
0.016690116375684738,
0.0011014440096914768,
-0.018983710557222366,
-0.004781562834978104,
-0.009122547693550587,
0.04856720194220543,
0.006002869922667742,
-0.014694558456540108,
-0.014059608802199364,
-0.019838949665427208,
0.0012326454743742943,
0.027212146669626236,
-0.003025731537491083,
0.06577564775943756,
0.015497964806854725,
0.010975565761327744,
-0.0257478728890419,
0.010625694878399372,
-0.006219919305294752,
0.007651796098798513,
0.02778230607509613,
0.014072567224502563,
-0.007340800482779741,
-0.02462051250040531,
-0.022339876741170883,
-0.007334321271628141,
0.01126712467521429,
0.004616346210241318,
0.04328026995062828,
-0.025022216141223907,
0.018076639622449875,
-0.0010479915654286742,
0.02583857998251915,
-0.018206221982836723,
-0.04338393732905388,
0.03498704358935356,
0.031540174037218094,
-0.003443632274866104,
0.03902999311685562,
0.018828213214874268,
0.013308035209774971,
0.020098114386200905,
-0.01443539559841156,
0.015925584360957146,
-0.00751573545858264,
-0.036438360810279846,
0.0310736782848835,
-0.005539615638554096,
0.0037902630865573883,
-0.02275453694164753,
0.008183080703020096,
0.02489263378083706,
-0.040766388177871704,
-0.01846538484096527,
0.02484080195426941,
0.008669012226164341,
0.014409479685127735,
0.03579045087099075,
0.01754535548388958,
-0.023143282160162926,
-0.013282119296491146,
0.023026658222079277,
0.011312478221952915,
-0.027030732482671738,
0.017856350168585777,
-0.003160172374919057,
-0.051988158375024796,
0.007885043509304523,
-0.006595705635845661,
-0.01234913058578968,
-0.010638653300702572,
-0.02879304252564907,
0.00979637261480093,
-0.006025546696037054,
-0.0040753427892923355,
-0.02375231683254242,
0.0053031290881335735,
-0.010120326653122902,
0.0028977696783840656,
0.001465892419219017,
-0.01770085282623768,
-0.008059978485107422,
-0.027289895340800285,
0.029104037210345268,
-0.0037481491453945637,
0.01452610269188881,
0.010599778965115547,
-0.014642726629972458,
-0.019139209762215614,
-0.005584969185292721,
0.017156610265374184,
-0.0018190023256465793,
-0.002917206846177578,
-0.0031407352071255445,
0.03195483610033989,
-0.004383099265396595,
0.01952795498073101,
-0.014668642543256283,
0.02165309339761734,
-0.02690115012228489,
-0.01854313351213932,
-0.014098483137786388,
0.014785265550017357,
-0.015290634706616402,
-0.002818400738760829,
0.014137357473373413,
0.026590153574943542,
0.05058867484331131,
-0.07816364616155624,
0.007250093389302492,
-0.006252314429730177,
0.0062361168675124645,
-0.02791188657283783,
0.006874306593090296,
-0.045768238604068756,
0.02072010561823845,
-0.019968532025814056,
0.021238431334495544,
0.043876346200704575,
-0.012660127133131027,
0.015161052346229553,
-0.0027633286081254482,
-0.021419845521450043,
0.029389116913080215,
0.03003702685236931,
-0.010418364778161049,
0.004768604412674904,
0.0412587970495224,
-0.01960570365190506,
0.026266200467944145,
-0.007159385830163956,
0.05369863659143448,
0.011889115907251835,
0.01183728314936161,
0.003514902200549841,
0.029622364789247513,
-0.024529805406928062,
0.025514626875519753,
0.043746765702962875,
0.034676048904657364,
-0.015303592197597027,
-0.005604406353086233,
-0.013035913929343224,
-0.0023681046441197395,
0.008098852820694447,
-0.007152907084673643,
-0.014694558456540108,
-0.007463902700692415,
-0.014383562840521336,
0.027212146669626236,
0.00309862126596272,
0.0045288787223398685,
-0.019864866510033607,
0.03947056829929352,
-0.05463162437081337,
0.011591078713536263,
0.02664198726415634,
-0.027004815638065338,
-0.010198075324296951,
-0.0016602649120613933,
-0.03628285974264145,
-0.013735654763877392,
-0.004240559414029121,
-0.025579417124390602,
-0.009103110991418362,
0.01952795498073101,
-0.0062004816718399525,
0.014072567224502563,
-0.01755831390619278,
0.058311741799116135,
0.034390971064567566,
-0.021886339411139488,
0.00433774571865797,
-0.017052944749593735,
-0.05675676092505455,
0.03845983371138573,
-0.029181787744164467,
0.015135136432945728,
-0.02485376037657261,
-0.007502777501940727,
-0.025410961359739304,
0.025475751608610153,
0.0073278420604765415,
0.02486671879887581,
-0.04058497026562691,
0.013308035209774971,
-0.02280637063086033,
-0.0128091461956501,
0.01553683914244175,
-0.012070530094206333,
-0.016754906624555588,
0.009232692420482635,
-0.02261199802160263,
0.0015930443769320846,
0.013644947670400143,
0.011610515415668488,
0.011830804869532585,
0.029518699273467064,
-0.008973529562354088,
0.02359681762754917,
-0.02381710708141327,
-0.023052575066685677,
0.02370048314332962,
-0.004457608796656132,
-0.03623102977871895,
0.0009751018951646984,
-0.011565161868929863,
-0.013282119296491146,
0.02767864055931568,
-0.02375231683254242,
0.01650870218873024,
0.018918920308351517,
-0.005283691454678774,
-0.01142262201756239,
0.010139764286577702,
-0.009044799022376537,
-0.010483155027031898,
-0.03814883530139923,
0.06105887144804001,
-0.026292115449905396,
0.032421328127384186,
0.008928175084292889,
-0.007412070408463478,
-0.00019923178479075432,
0.03506479412317276,
-0.0038161794655025005,
0.051210667937994,
-0.025229547172784805,
0.041595708578825,
0.0014326870441436768,
-0.00442197360098362,
-0.007016846444457769,
-0.0015898048877716064,
0.016094040125608444,
-0.01133191492408514,
-0.026460573077201843,
-0.01082006748765707,
0.011558682657778263,
0.0061356909573078156,
0.002034431789070368,
-0.020007407292723656,
-0.013100704178214073,
0.0002474199573043734,
0.03923732414841652,
0.009342837147414684,
0.004775083623826504,
0.004217882640659809,
0.04320252314209938,
-0.032628659158945084,
-0.0257867481559515,
0.0007815393037162721,
-0.018335802480578423,
0.009861163794994354,
-0.01135135255753994,
-0.019916698336601257,
-0.0029771383851766586,
-0.004499722737818956,
-0.0045904298312962055,
-0.0014966679736971855,
0.019942615181207657,
0.0058797672390937805,
0.022313959896564484,
-0.0005329045234248042,
0.010781193152070045,
-0.009096631780266762,
-0.022210294380784035,
-0.03597186505794525,
0.014500186778604984,
-0.06800445169210434,
0.0414920449256897,
-0.03589411824941635,
-0.017934100702404976,
0.030218441039323807,
0.011798408813774586,
-0.03700852021574974,
-0.013968901708722115,
0.029700113460421562,
0.03415772318840027,
-0.0054618665017187595,
-0.05587560683488846,
0.04219178482890129,
-0.0043312665075063705,
-0.046908557415008545,
0.014344688504934311,
0.021938173100352287,
-0.012038134969770908,
0.029207702726125717,
0.033535730093717575,
-0.02056460827589035,
-0.01652166061103344,
-0.00390688655897975,
0.006764161866158247,
0.01948907971382141,
0.0009686228004284203,
-0.0259292870759964,
-0.005753424949944019,
0.011396706104278564,
-0.0128091461956501,
0.003942521754652262,
0.002591633005067706,
0.02283228561282158,
0.03835616633296013,
0.02467234618961811,
-0.03928915411233902,
0.01763606257736683,
0.025281378999352455,
-0.06406516581773758,
-0.04670122638344765,
-0.015070345252752304,
0.01662532612681389,
0.03628285974264145,
0.006019067484885454,
-0.019035544246435165,
0.02801555208861828,
0.006035265047103167,
-0.022495374083518982,
0.011908553540706635,
0.03939282149076462,
0.007288967724889517,
0.019851908087730408,
-0.06085154041647911,
0.024465015158057213,
0.008992966264486313,
-0.010768234729766846,
-0.03081451542675495,
0.004898186307400465,
-0.018141429871320724,
-0.009174380451440811,
-0.04309885576367378,
-0.03213625028729439,
0.05572010949254036,
-0.0019323863089084625,
0.01125416625291109,
-0.018245095387101173,
0.04745279997587204,
0.0036444838624447584,
-0.0021964090410619974,
-0.00026037811767309904,
-0.013865236192941666,
0.030529435724020004,
0.006666975561529398,
-0.0057210298255085945,
-0.012524066492915154,
0.0009273186442442238,
-0.02364865131676197,
-0.007606442552059889,
-0.05242873355746269,
-0.0009030221262946725,
0.017130693420767784,
-0.0075870053842663765,
0.017726769670844078,
-0.03218808025121689,
-0.017791559919714928,
-0.028093300759792328,
0.0257867481559515,
-0.03291373699903488,
-0.031514257192611694,
-0.0007823492051102221,
-0.009705665521323681,
-0.00046770877088420093,
0.01770085282623768,
0.020888561382889748,
0.05250648409128189,
-0.03203258290886879,
-0.0207719374448061,
0.01862088218331337,
0.039807483553886414,
-0.003145594382658601,
-0.02489263378083706,
0.01942428946495056,
-0.027549058198928833,
0.015977418050169945,
-0.02459459751844406,
-0.002220705384388566,
0.012640689499676228,
-0.007379674818366766,
-0.005533136427402496,
-0.020175863057374954,
-0.004315068945288658,
-0.020214736461639404,
-0.010781193152070045,
-0.009945391677320004,
-0.043928179889917374,
0.014383562840521336,
0.035634953528642654,
0.007833210751414299,
-0.014085524715483189,
0.02173084206879139,
0.00774250365793705,
-0.018141429871320724,
-0.01496668066829443,
-0.00774250365793705,
0.010334135964512825,
0.0016051926650106907,
0.0033723623491823673,
-0.012238986790180206,
-0.02570899948477745,
-0.004088301211595535,
-0.02489263378083706,
0.011299519799649715,
0.007379674818366766,
0.012018698267638683,
-0.019009627401828766,
-0.022145504131913185,
-0.01643095351755619,
0.0010917254257947206,
0.0036574420519173145,
0.001982599264010787,
-0.018789339810609818,
0.028145134449005127,
0.0029366440139710903,
-0.010204554535448551,
0.0103276576846838,
-0.021510552614927292,
0.00875971931964159,
-0.0031358757987618446,
-0.02066827192902565,
-0.010586820542812347,
-0.03205849975347519,
0.02569604106247425,
0.005180026404559612,
-0.04053314030170441,
-0.020111070945858955,
0.0019566828850656748,
-0.019359497353434563,
0.021406888961791992,
0.03729359805583954,
-0.026356907561421394,
-0.011558682657778263,
0.002324370900169015,
-0.007308404892683029,
0.015303592197597027,
-0.028637543320655823,
0.014176231808960438,
-0.009900038130581379,
-0.005384117364883423,
-0.01956682838499546,
-0.007049241568893194,
0.01135783176869154,
0.008882821537554264,
-0.006945576518774033,
-0.012776750139892101,
0.014785265550017357,
0.015161052346229553,
-0.010554425418376923,
0.006339781917631626,
-0.011247687041759491,
-0.025320254266262054,
0.006790078245103359,
-0.004253517370671034,
-0.010450759902596474,
-0.00700388802215457,
0.029129954054951668,
-0.03680118918418884,
0.01495372224599123,
-0.04027397558093071,
-0.0007284918101504445,
-0.036697521805763245,
0.06276935338973999,
-0.024413183331489563,
-0.040636803954839706,
0.04260644689202309,
-0.005238337907940149,
-0.028274714946746826,
-0.004745927639305592,
-0.0069714924320578575,
-0.002402119804173708,
0.02278045378625393,
-0.01244631689041853,
0.04423917457461357,
0.023298779502511024,
-0.03936690464615822,
-0.0030565070919692516,
0.025372086092829704,
0.015316550619900227,
0.009154943749308586,
0.005060163326561451,
0.008980007842183113,
0.00619724253192544,
0.03845983371138573,
-0.018374677747488022,
-0.007561089005321264,
0.007256572134792805,
0.012232507579028606,
0.013554240576922894,
0.020422067493200302,
0.011662348173558712,
0.024400224909186363,
0.024283600971102715,
0.004671418573707342,
-0.028067385777831078,
-0.04242503270506859,
-0.003945761360228062,
-0.03628285974264145,
-0.01186319999396801,
-0.03407997265458107,
0.0064888009801507,
-0.04429100826382637,
-0.01135135255753994,
-0.008221955969929695,
-0.015705294907093048,
0.028093300759792328,
-0.021121809259057045,
0.009763977490365505,
0.03799333795905113,
0.027341727167367935,
0.0129711227491498,
-0.023467237129807472,
-0.00885690562427044,
-0.008416327647864819,
0.030555352568626404,
-0.0009694327018223703,
0.0025559980422258377,
0.0018530176021158695,
0.00833857897669077,
0.00920677650719881,
0.011221771128475666,
0.004467327147722244,
-0.027471309527754784,
0.005471584852784872,
-0.01444835402071476,
-0.002170492662116885,
-0.0206034816801548,
-0.021251389756798744,
0.002915587043389678,
-0.011558682657778263,
-0.03620511293411255,
-0.011830804869532585,
0.010470197536051273,
-0.014124399982392788,
0.008578305132687092,
0.0000546672563359607,
-0.010483155027031898,
-0.027134396135807037,
0.014746391214430332,
0.007347279228270054,
0.010554425418376923,
0.006330063566565514,
0.024374308064579964,
0.016690116375684738,
0.025009257718920708,
0.03804517164826393,
-0.018037766218185425,
0.016780823469161987,
0.007114032283425331,
0.00619724253192544,
-0.021899297833442688,
-0.013593114912509918,
0.010729360394179821,
0.006044983863830566,
0.04931877553462982,
0.011150500737130642,
0.00920677650719881,
-0.018763422966003418,
-0.014629768207669258,
-0.020227694883942604,
0.023195115849375725,
0.008299704641103745,
0.026512404903769493,
-0.003404757706448436,
-0.011053314432501793,
-0.027367644011974335,
-0.00883746799081564,
0.008092373609542847,
-0.010016661137342453,
0.0051605892367661,
0.021044058725237846,
0.034365054219961166,
-0.028326548635959625,
-0.03278415650129318,
-0.010884858667850494,
-0.0017428731080144644,
0.009589041583240032,
0.005572010762989521,
0.019139209762215614,
0.0035084232222288847,
-0.02988152764737606,
0.031592004001140594,
0.019294707104563713,
0.016288412734866142,
0.03685301914811134,
0.016262495890259743,
0.03480562940239906,
-0.04618290066719055,
0.0058182161301374435,
0.016288412734866142,
0.012070530094206333,
0.04449833929538727,
-0.020305443555116653,
0.013126621022820473,
-0.009725102223455906,
0.003190948162227869,
0.02149759605526924,
0.009038319811224937,
0.012945206835865974,
-0.01339874230325222,
-0.012238986790180206,
-0.0024264163803309202,
-0.022132545709609985,
-0.005173547193408012,
0.014228064566850662,
-0.003579692915081978,
-0.008643096312880516,
-0.021847466006875038,
-0.025320254266262054,
0.01332099363207817,
-0.01758422888815403,
0.038718994706869125,
-0.03384672477841377,
-0.021393930539488792,
-0.0041757686994969845,
-0.0206034816801548,
-0.009504813700914383,
0.030788598582148552,
-0.015575714409351349,
-0.030529435724020004,
0.020201778039336205,
0.020059239119291306,
-0.02161421813070774,
-0.027367644011974335,
0.0030548872891813517,
-0.0015938542783260345,
0.0412069633603096,
-0.022897077724337578,
0.01341170072555542,
0.04444650560617447,
0.053232140839099884,
0.029129954054951668,
0.01649574376642704,
-0.0038744912017136812,
-0.013087746687233448,
-0.018141429871320724,
-0.027523141354322433,
-0.005079600494354963,
-0.002983617363497615,
0.026097744703292847,
-0.03892632573843002,
-0.016923362389206886,
0.019022585824131966,
-0.02373935841023922,
0.016793781891465187,
-0.011629953049123287,
-0.0513661652803421,
0.003433913690969348,
-0.020292485132813454,
-0.024296559393405914,
-0.016793781891465187,
-0.0154461320489645,
-0.03579045087099075,
0.013437616638839245,
0.017156610265374184,
-0.009440023452043533,
0.031125511974096298,
0.013580156490206718,
0.025436878204345703,
-0.0410773828625679,
-0.023480193689465523,
0.024400224909186363,
0.06676046550273895,
-0.026123659685254097,
0.001293386798352003,
0.016832655295729637,
-0.0030386897269636393,
-0.0256182923913002,
-0.018037766218185425,
0.0053614405915141106,
-0.029155870899558067,
-0.020162904635071754,
0.002751990221440792,
-0.008798593655228615,
-0.0035699743311852217,
0.01639207825064659,
0.01843946799635887,
0.01442243717610836,
-0.018141429871320724,
-0.016845613718032837,
-0.025151798501610756,
0.0073278420604765415,
-0.022041838616132736,
0.011403185315430164,
-0.010107368230819702,
0.005484543275088072,
-0.004357182886451483,
0.003343206597492099,
-0.01184376236051321,
-0.0027746669948101044,
-0.027367644011974335,
0.003540818579494953,
-0.04024805873632431,
-0.03086634911596775,
-0.027212146669626236,
-0.011759534478187561,
0.0102952616289258,
0.005484543275088072,
-0.03625694662332535,
-0.020875602960586548,
0.007399111986160278,
0.0021364775020629168,
-0.024063311517238617,
-0.004881988745182753,
-0.01869863085448742,
-0.02075898088514805,
0.018361719325184822,
0.024516846984624863,
-0.004726490471512079,
-0.005358200985938311,
-0.013761570677161217,
-0.004282673355191946,
-0.044964831322431564,
0.008869864046573639,
-0.009524251334369183,
0.0023583860602229834,
-0.03405405580997467,
-0.0014974778750911355,
-0.028378380462527275,
-0.03293965384364128,
0.012115883640944958,
0.01951499655842781,
-0.012763792648911476,
0.02166605181992054,
0.018802296370267868,
0.008643096312880516,
-0.009148464538156986,
0.0054651061072945595,
0.008059978485107422,
-0.01755831390619278,
0.0009726722491905093,
0.026382822543382645,
0.007794335950165987,
0.04618290066719055,
-0.020966310054063797,
0.01443539559841156,
-0.005591447930783033,
0.04017031192779541,
-0.003780544502660632,
-0.01074879802763462,
0.04916327819228172,
-0.008383932523429394,
-0.009582563303411007,
0.02074602246284485,
0.011396706104278564,
-0.03102184645831585,
-0.015109220519661903,
-0.006666975561529398,
-0.022378750145435333,
0.012848020531237125,
-0.004564513452351093,
0.0013533183373510838,
-0.022495374083518982,
0.00324278068728745,
0.043902263045310974,
0.021290265023708344,
-0.02261199802160263,
0.04328026995062828,
0.009757498279213905,
-0.011195854283869267,
-0.008513513952493668,
-0.024257684126496315,
-0.017299149185419083,
-0.00980933103710413,
-0.009394669905304909,
0.00640133349224925,
-0.0006321154651232064,
-0.0062361168675124645,
-0.02364865131676197,
0.027315812185406685,
-0.0073278420604765415,
-0.005468345712870359,
-0.0077878572046756744,
0.009835246950387955,
-0.012226028367877007,
0.017947059124708176,
0.024231767281889915,
-0.014824140816926956,
0.010275824926793575,
0.01659940928220749,
-0.020409109070897102,
0.009135506115853786,
-0.009971307590603828,
0.011092188768088818,
-0.02687523327767849,
-0.028093300759792328,
0.08049611747264862,
-0.044938914477825165,
-0.008617179468274117,
0.0020279528107494116,
-0.00987412128597498,
0.007716587278991938,
-0.006051463074982166,
-0.0006701800739392638,
-0.004930581897497177,
-0.013372826389968395,
0.02475009486079216,
-0.0019485839875414968,
0.03008885867893696,
0.004765365272760391,
0.0207719374448061,
-0.01759718731045723,
-0.0035537767689675093,
0.017130693420767784,
0.012608294375240803,
-0.002562477020546794,
-0.009517772123217583,
0.0027811462059617043,
-0.0412587970495224,
0.03200666606426239,
-0.025307295843958855,
0.005397075787186623,
-0.004068863578140736,
0.019048502668738365,
0.011221771128475666,
-0.03534987196326256,
-0.01663828268647194,
0.025294337421655655,
0.039729733020067215,
-0.007237134966999292,
0.014577935449779034,
0.029440950602293015,
-0.01495372224599123,
-0.011714180931448936,
0.016793781891465187,
0.01768789440393448,
0.004817197564989328,
0.011604036204516888,
-0.009679748676717281,
0.011202333495020866,
0.008617179468274117,
0.006028786301612854,
-0.04307293891906738,
-0.010677527636289597,
0.004671418573707342,
-0.0027973437681794167,
0.0011403184616938233,
-0.010988524183630943,
0.03296557068824768,
0.007761940825730562,
-0.01400777604430914,
-0.020059239119291306,
0.034546468406915665,
0.0035537767689675093,
-0.006145409774035215,
-0.01761014573276043,
-0.018802296370267868,
0.022987784817814827,
0.02905220538377762,
0.025268420577049255,
0.001993937650695443
] | 2024-07-01 | 48 | 38948924 | [
"BT progressors",
"systemic BT",
"BT",
"pre-apheresis bendamustine exposure",
"Patients",
"patients",
"bendamustine",
"efficacy analyses",
"chimeric antigen receptor",
"R/R LBCL patients",
"leukapheresis",
"LBCL",
"Separate safety",
"two BT groups",
"the non-benda group",
"Bendamustine-containing regimens",
"Bridging therapy",
"steroids",
"September",
"February",
"CAR",
"CAR-T outcomes",
"benda",
"CAR) T cells",
"a potential BT option",
"243 patients",
"a negative impact",
"tisa-cel",
"a higher rate",
"26%"
] | [] | 0 | 10.1002/hem3.86
10.1016/S1470-2045(18)30864-7
10.1016/S1470-2045(21)00375-2
10.1016/S0140-6736(20)31366-0
10.1182/blood.2022018893
10.1038/s41591-022-01969-y
10.3324/haematol.2022.280805
10.1182/blood.2021015209
10.1111/bjh.18209
10.1016/j.jtct.2022.05.026
10.1182/bloodadvances.2020003092
10.1002/cam4.3881
10.1038/s41375-022-01739-2
10.1182/bloodadvances.2022008240
10.1182/blood.2022016945
10.1182/bloodadvances.2020003001
10.1007/s00277-021-04560-6
10.1182/bloodadvances.2020001900
10.1136/jitc-2021-004475
10.1182/bloodadvances.2020002394
10.1182/bloodadvances.2020001837
10.1182/bloodadvances.2022009019
10.1097/HS9.0000000000000907
10.1182/bloodadvances.2023011489
10.1182/bloodadvances.2021005794
10.1016/j.bbmt.2019.08.015
10.1200/JCO.21.02370
10.1200/JCO.23.01097
10.1182/blood.2023021243
10.1016/j.annonc.2022.05.521
10.1002/ajh.27069
10.1182/bloodadvances.2023011492
10.1172/jci.insight.134612
10.1038/s41591-022-01916-x
10.1038/s41591-023-02754-1
10.1016/j.bbmt.2018.12.758
10.1200/JCO.2013.54.8800
10.1002/cyto.b.21941
10.1002/1097-0320(20001215)42:6<327::AID-CYTO1000>3.0.CO;2-F
10.3389/fimmu.2022.830773
10.1182/bloodadvances.2023010364
10.18637/jss.v045.i03
10.1182/blood-2017-07-793760
10.1016/j.bbmt.2015.09.013
10.1111/bjh.15722
10.1186/s12879-019-4545-7
10.3109/10428194.2015.1026818
10.1038/bcj.2015.86
10.3109/10428194.2015.1110748 | [
"Iacoboni",
"Sánchez-Salinas",
"Rejeski",
"Martín-López",
"Kwon",
"Navarro",
"Jalowiec",
"Hernani",
"Reguera-Ortega",
"Gallur",
"Blumenberg",
"Herrero-García",
"Roddie",
"Benzaquén",
"Delgado-Serrano",
"Bailén",
"Carpio",
"Amat",
"López-Corral",
"Martín-Martín",
"Bastos",
"Subklewe",
"O'Reilly",
"Barba"
] | [
"Department of Hematology University Hospital Vall d'Hebron Barcelona Spain.\nExperimental Hematology, Vall d'Hebron Institute of Oncology (VHIO) Barcelona Spain.\nDepartment of Medicine Universitat Autònoma de Barcelona Bellaterra Spain.",
"Department of Hematology University Hospital Vall d'Hebron Barcelona Spain.\nExperimental Hematology, Vall d'Hebron Institute of Oncology (VHIO) Barcelona Spain.\nDepartment of Medicine Universitat Autònoma de Barcelona Bellaterra Spain.",
"Department of Medicine III University Hospital, LMU Munich Munich Germany.\nLaboratory for Translational Cancer Immunology Gene Center of the LMU Munich Munich Germany.\nAdult BMT and Cellular Therapy Service Memorial Sloan Kettering Cancer Center New York New York USA.",
"Hematology Department Hospital Clínico Universitario de Salamanca, IBSAL, CIBERONC Salamanca Spain.\nCentro de Investigación del Cáncer-IBMCC Salamanca Spain.",
"Department of Hematology Hospital General Universitario Gregorio Marañón Madrid Spain.\nGregorio Marañón Health Research Institute (IiSGM) Madrid Spain.",
"Oncology Data Science (ODySey) Group, Vall d'Hebron Institute of Oncology (VHIO) Barcelona Spain.",
"Hematology Department University College London Cancer Institute London United Kingdom.\nDepartment of Hematology and Central Hematology Laboratory University Hospital of Bern Bern Switzerland.",
"Haematology Department Hospital Clínico Universitario Valencia Spain.\nINCLIVA Research Institute Valencia Spain.",
"Hematology Department, Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC Universidad de Sevilla Sevilla Spain.",
"Department of Hematology University Hospital Vall d'Hebron Barcelona Spain.\nExperimental Hematology, Vall d'Hebron Institute of Oncology (VHIO) Barcelona Spain.\nDepartment of Medicine Universitat Autònoma de Barcelona Bellaterra Spain.",
"Department of Medicine III University Hospital, LMU Munich Munich Germany.\nLaboratory for Translational Cancer Immunology Gene Center of the LMU Munich Munich Germany.",
"Cancer Research Centre (IBMCC, USAL-CSIC), Institute for Biomedical Research of Salamanca (IBSAL) and Department of Medicine and Cytometry Service (NUCLEUS Research Support Platform) University of Salamanca (USAL) Salamanca Spain.",
"Hematology Department University College London Cancer Institute London United Kingdom.",
"Haematology Department Hospital Clínico Universitario Valencia Spain.\nINCLIVA Research Institute Valencia Spain.",
"Hematology Department, Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC Universidad de Sevilla Sevilla Spain.",
"Department of Hematology Hospital General Universitario Gregorio Marañón Madrid Spain.\nGregorio Marañón Health Research Institute (IiSGM) Madrid Spain.",
"Department of Hematology University Hospital Vall d'Hebron Barcelona Spain.\nExperimental Hematology, Vall d'Hebron Institute of Oncology (VHIO) Barcelona Spain.\nDepartment of Medicine Universitat Autònoma de Barcelona Bellaterra Spain.",
"Haematology Department Hospital Clínico Universitario Valencia Spain.\nINCLIVA Research Institute Valencia Spain.",
"Hematology Department Hospital Clínico Universitario de Salamanca, IBSAL, CIBERONC Salamanca Spain.\nCentro de Investigación del Cáncer-IBMCC Salamanca Spain.",
"Cancer Research Centre (IBMCC, USAL-CSIC), Institute for Biomedical Research of Salamanca (IBSAL) and Department of Medicine and Cytometry Service (NUCLEUS Research Support Platform) University of Salamanca (USAL) Salamanca Spain.",
"Department of Hematology Hospital General Universitario Gregorio Marañón Madrid Spain.\nGregorio Marañón Health Research Institute (IiSGM) Madrid Spain.",
"Department of Medicine III University Hospital, LMU Munich Munich Germany.\nLaboratory for Translational Cancer Immunology Gene Center of the LMU Munich Munich Germany.",
"Hematology Department University College London Cancer Institute London United Kingdom.",
"Department of Hematology University Hospital Vall d'Hebron Barcelona Spain.\nExperimental Hematology, Vall d'Hebron Institute of Oncology (VHIO) Barcelona Spain.\nDepartment of Medicine Universitat Autònoma de Barcelona Bellaterra Spain."
] | [
"38948924",
"30518502",
"34516954",
"32888407",
"36821768",
"36138152",
"35770532",
"35316325",
"35485402",
"35609867",
"33147337",
"33932100",
"36335261",
"36094847",
"36122385",
"33180899",
"34236497",
"32702097",
"35580927",
"33035333",
"32589728",
"36724512",
"37449196",
"38051550",
"34749395",
"31446199",
"35658525",
"37874957",
"37879047",
"35690221",
"37668287",
"38113468",
"32484797",
"36038629",
"38233586",
"30592986",
"25113753",
"32841511",
"11135287",
"35309367",
"37748131",
"29038338",
"26409243",
"30548597",
"31640581",
"25760636",
"26495859",
"26696321"
] | [] | 6.115425 | 5.565016 |
38948258 | 789 | A Flow Cytometry-Based Method for Assessing CAR Cell Binding Kinetics Using Stable CAR Jurkat Cells. | Chimeric antigen receptors (CARs) are synthetic fusion proteins that can reprogram immune cells to target specific antigens. CAR-expressing T cells have emerged as an effective treatment method for hematological cancers; despite this success, the mechanisms and structural properties that govern CAR responses are not fully understood. Here, we provide a simple assay to assess cellular avidity using a standard flow cytometer. This assay measures the interaction kinetics of CAR-expressing T cells and targets antigen-expressing target cells. By co-culturing stably transfected CAR Jurkat cells with target positive and negative cells for short periods of time in a varying effector-target gradient, we were able to observe the formation of CAR-target cell doublets, providing a readout of actively bound cells. When using the optimized protocol reported here, we observed unique cellular binding curves that varied between CAR constructs with differing antigen binding domains. The cellular binding kinetics of unique CARs remained consistent, were dependent on specific target antigen expression, and required active biological signaling. While existing literature is not clear at this time whether higher or lower CAR cell binding is beneficial to CAR therapeutic activity, the application of this simplified protocol for assessing CAR binding could lead to a better understanding of the proximal signaling events that regulate CAR functionality. Key features • Determines CAR receptor cellular interaction kinetics using a Jurkat cell model. • Can be used for a wide variety of CAR target antigens, including both hematological and solid tumor targets. • Experiments can be performed in under two hours with no staining using a standard flow cytometer. • Requires stable CAR Jurkat cells and target cells with stable fluorescent marker expression for optimal results. | [
-0.011366625316441059,
0.009076152928173542,
0.03601064532995224,
0.025844374671578407,
-0.028196090832352638,
-0.01081544253975153,
-0.024607274681329727,
-0.003842972917482257,
0.007300117518752813,
0.0042043039575219154,
0.002766634337604046,
-0.040003664791584015,
-0.007728815544396639,
0.005220931023359299,
0.026603782549500465,
-0.05521632358431816,
0.019266920164227486,
-0.012922187335789204,
0.03331597149372101,
0.0015119265299290419,
0.012603726238012314,
-0.026873251423239708,
-0.0005354899330995977,
0.0254279263317585,
-0.012193400412797928,
-0.04211040958762169,
0.02905348688364029,
-0.01294668484479189,
-0.02448478899896145,
-0.03662307187914848,
0.0017622556770220399,
-0.015457631088793278,
-0.028612541034817696,
-0.032532066106796265,
-0.01578834094107151,
0.045074548572301865,
0.01480845920741558,
0.008071773685514927,
-0.03297301381826401,
-0.026334315538406372,
0.041669461876153946,
0.02773064747452736,
0.017809346318244934,
0.06707289069890976,
-0.053354550153017044,
-0.0006219951319508255,
0.017086684703826904,
-0.027020232751965523,
-0.00086658273357898,
0.04078756645321846,
-0.07128638029098511,
0.026603782549500465,
-0.02692224457859993,
0.009192513301968575,
-0.022047333419322968,
0.052374668419361115,
-0.025844374671578407,
0.01655999757349491,
-0.014073547907173634,
0.016878459602594376,
0.032654549926519394,
-0.005346478428691626,
0.004342100117355585,
-0.02240254171192646,
-0.040983542799949646,
0.01911993883550167,
-0.05379549413919449,
-0.003016197821125388,
0.026603782549500465,
0.03941573575139046,
0.048185672610998154,
-0.011611595749855042,
0.015065678395330906,
0.001161312684416771,
0.006179377902299166,
0.011440116912126541,
-0.010392867960035801,
0.03525123745203018,
0.0018265603575855494,
0.007440975401550531,
0.056980110704898834,
-0.0055700140073895454,
-0.0254279263317585,
-0.0797133594751358,
0.010496980510652065,
-0.018874967470765114,
0.03370792418718338,
-0.045931946486234665,
-0.00960283912718296,
0.010944051668047905,
0.01800532266497612,
0.042943306267261505,
-0.05560827627778053,
0.05056188628077507,
-0.0002507118624635041,
0.025844374671578407,
-0.05252164974808693,
-0.057274073362350464,
0.025868872180581093,
0.02606484852731228,
0.07785158604383469,
0.018764730542898178,
-0.013424376957118511,
-0.01855650544166565,
0.03990567475557327,
0.005475088022649288,
-0.049386028200387955,
0.019389405846595764,
0.025917865335941315,
-0.03613313287496567,
0.10592519491910934,
-0.025501416996121407,
-0.005380162037909031,
0.04830816015601158,
0.016021063551306725,
-0.04911656305193901,
-0.029714906588196754,
-0.0013190123718231916,
-0.012187276035547256,
0.007679821457713842,
-0.024595025926828384,
0.01723366603255272,
0.047254785895347595,
-0.014000057242810726,
0.023051712661981583,
-0.035177744925022125,
0.06702389568090439,
-0.03525123745203018,
-0.030474314466118813,
-0.045882951468229294,
0.012554732151329517,
-0.01426952425390482,
-0.006246744655072689,
-0.02444804459810257,
-0.02589336968958378,
-0.010013164021074772,
0.021189937368035316,
-0.011758578009903431,
-0.03980768844485283,
-0.004629940260201693,
0.03174816071987152,
-0.0037357984110713005,
-0.009412987157702446,
0.03662307187914848,
-0.048112183809280396,
-0.011972927488386631,
-0.04073857516050339,
0.036500588059425354,
0.01218115258961916,
0.05408946052193642,
0.0035704432521015406,
0.04923904687166214,
0.04740176722407341,
-0.009223135188221931,
-0.01440425869077444,
-0.027926623821258545,
-0.013902069069445133,
0.02338242344558239,
-0.0389992855489254,
-0.04784271493554115,
0.002962610451504588,
0.0038827804382890463,
-0.01731940545141697,
-0.013583607971668243,
-0.025207452476024628,
-0.018838223069906235,
-0.028171593323349953,
0.034883782267570496,
-0.07143336534500122,
0.02956792525947094,
-0.00541996955871582,
-0.019977334886789322,
-0.03515325114130974,
-0.027412185445427895,
-0.03537372127175331,
-0.0024221446365118027,
-0.01945064775645733,
0.022169819101691246,
-0.035814668983221054,
-0.009559969417750835,
0.015494376420974731,
-0.004026700742542744,
0.05585324764251709,
-0.013938814401626587,
0.018874967470765114,
-0.009725323878228664,
-0.016535500064492226,
0.03370792418718338,
-0.03958721458911896,
-0.05722508206963539,
-0.0012945153284817934,
0.03997916728258133,
0.04617691785097122,
0.039146266877651215,
-0.0008198852301575243,
-0.03140520304441452,
0.05693111568689346,
0.035398218780756,
-0.028392067179083824,
-0.04421715438365936,
-0.004158372059464455,
-0.03792141377925873,
-0.032189108431339264,
-0.028514552861452103,
-0.010784820653498173,
0.02492573671042919,
-0.01105428859591484,
0.006072203163057566,
-0.03662307187914848,
0.020663252100348473,
0.06383927911520004,
-0.0005400831578299403,
-0.03801940381526947,
0.0489695779979229,
-0.0360841378569603,
-0.01220564916729927,
-0.0038766562938690186,
0.03490827977657318,
-0.009909051470458508,
0.007238874677568674,
-0.038337863981723785,
-0.0011980582494288683,
-0.0040726326406002045,
-0.0014522150158882141,
-0.07770460098981857,
0.00628349045291543,
0.005998712033033371,
-0.043972183018922806,
-0.0017239790176972747,
-0.05903786048293114,
-0.008849554695189,
0.035520706325769424,
0.019597630947828293,
-0.03973419591784477,
-0.021447157487273216,
0.011917809024453163,
0.034761298447847366,
-0.0018969894153997302,
0.05149277299642563,
-0.03699052706360817,
-0.009455856867134571,
0.01698869653046131,
0.023321179673075676,
-0.017478637397289276,
-0.023321179673075676,
-0.03054780699312687,
-0.03165017440915108,
-0.06413324922323227,
0.019695619121193886,
-0.02807360514998436,
0.002863091416656971,
-0.004828978795558214,
-0.02068774774670601,
-0.0007349111256189644,
0.02333342842757702,
0.01128701027482748,
0.02252502553164959,
-0.021312423050403595,
0.0072449990548193455,
-0.028563546016812325,
0.002959548495709896,
-0.0017775662709027529,
-0.03214011341333389,
-0.044903069734573364,
-0.03167467191815376,
0.003056005574762821,
-0.019046446308493614,
-0.000029472997994162142,
-0.008561714552342892,
-0.01762561872601509,
0.027485676109790802,
0.02679975889623165,
0.05350153148174286,
-0.03353644534945488,
-0.08681750297546387,
0.029126977548003197,
-0.016657985746860504,
0.0204427782446146,
0.014171536080539227,
0.032017629593610764,
-0.017037689685821533,
0.01510242372751236,
0.01561686210334301,
-0.007526714820414782,
-0.016413016244769096,
-0.022880233824253082,
-0.005530206486582756,
-0.028833013027906418,
0.03182165324687958,
0.0017683799378573895,
0.00521786930039525,
-0.02444804459810257,
-0.009357868693768978,
-0.026726268231868744,
-0.00003693694088724442,
0.003282603109255433,
-0.024546032771468163,
-0.016315028071403503,
-0.05541229993104935,
0.008279998786747456,
-0.04505005106329918,
-0.017086684703826904,
-0.0017714420100674033,
-0.011207395233213902,
0.006497839465737343,
0.06775880604982376,
-0.0004937684279866517,
0.008108519949018955,
0.028000114485621452,
0.030474314466118813,
0.011783075518906116,
0.02704473026096821,
0.004734052810817957,
0.02760816179215908,
-0.022035086527466774,
0.01608230546116829,
0.01621703989803791,
-0.03532472997903824,
0.017429642379283905,
-0.036157626658678055,
-0.04304129630327225,
-0.034540824592113495,
-0.002194016007706523,
-0.00287993298843503,
0.040297627449035645,
-0.03346295282244682,
0.004633002448827028,
-0.037651948630809784,
0.01659674383699894,
0.004960650112479925,
0.022598518058657646,
-0.03716200590133667,
0.02986188977956772,
-0.026995735242962837,
0.028979996219277382,
-0.0245705284178257,
-0.03588816151022911,
-0.052717626094818115,
0.02927396073937416,
0.05281561240553856,
0.008861803449690342,
0.045074548572301865,
-0.033732421696186066,
0.05443241819739342,
0.03571668267250061,
0.010349998250603676,
0.01455124095082283,
0.04882259666919708,
0.009939673356711864,
-0.016927452757954597,
-0.001495084841735661,
0.013167157769203186,
-0.01403680257499218,
0.018078813329339027,
0.03554520383477211,
0.0410570353269577,
-0.015604613348841667,
-0.01288544200360775,
0.025182954967021942,
0.010784820653498173,
0.03941573575139046,
0.0060477061197161674,
-0.015800589695572853,
0.04556449130177498,
0.027338694781064987,
0.03657407686114311,
-0.03836236149072647,
0.02513396181166172,
-0.023443665355443954,
-0.030792776495218277,
-0.037823427468538284,
0.015371891669929028,
0.017613369971513748,
0.0005370210274122655,
-0.002446641679853201,
-0.007820679806172848,
0.044266149401664734,
0.018201299011707306,
0.04884709417819977,
-0.027755144983530045,
0.050414904952049255,
-0.01621703989803791,
-0.005863978527486324,
-0.03997916728258133,
0.027338694781064987,
0.001817374024540186,
0.015751594677567482,
0.013595855794847012,
-0.09553844481706619,
0.050855852663517,
-0.0010036129970103502,
-0.030866267159581184,
-0.014245027676224709,
-0.032654549926519394,
-0.0182992871850729,
0.0410570353269577,
-0.00125623878557235,
0.06756283342838287,
0.05570626258850098,
0.004231863189488649,
-0.03294851630926132,
-0.03003336861729622,
-0.013755086809396744,
-0.0018709612777456641,
0.018250294029712677,
-0.027485676109790802,
0.012340382672846317,
0.01881372556090355,
0.04176744818687439,
0.025452421978116035,
0.025942362844944,
0.01188106369227171,
0.025917865335941315,
0.02645680122077465,
0.005392410326749086,
-0.03784792497754097,
-0.055951233953237534,
0.05340354144573212,
-0.0029365825466811657,
0.0016964199021458626,
0.0020485648419708014,
-0.059968747198581696,
0.019303666427731514,
-0.00628349045291543,
-0.0012631284771487117,
0.01211990974843502,
0.030302835628390312,
0.01663348823785782,
0.00605995487421751,
-0.054040465503931046,
-0.016951950266957283,
0.030400823801755905,
0.01728266105055809,
-0.013228400610387325,
-0.005352602805942297,
0.017944080755114555,
0.0020929656457155943,
0.0011704991338774562,
-0.050414904952049255,
0.03282603248953819,
-0.009278252720832825,
0.012762957252562046,
0.010613341815769672,
-0.015139169059693813,
-0.006577454507350922,
0.030572302639484406,
-0.005392410326749086,
-0.01664573699235916,
-0.007900294847786427,
-0.003481641411781311,
-0.05673513934016228,
-0.01510242372751236,
-0.010478608310222626,
0.010398992337286472,
-0.03387940302491188,
-0.00021186110097914934,
0.02995987795293331,
-0.028392067179083824,
0.018360529094934464,
0.0065345847979187965,
0.040812063962221146,
-0.018801476806402206,
0.0027176402509212494,
-0.006846921984106302,
-0.019720114767551422,
0.0742260217666626,
0.022084079682826996,
-0.014759465120732784,
0.013473371043801308,
-0.026187334209680557,
-0.013252897188067436,
-0.027706149965524673,
-0.006350857205688953,
0.03547171130776405,
-0.031601179391145706,
0.04372721165418625,
0.037357982248067856,
-0.009939673356711864,
0.009492602199316025,
0.003288727253675461,
-0.01083993911743164,
-0.029249463230371475,
-0.019303666427731514,
0.00883118249475956,
0.03209111839532852,
0.03157668188214302,
0.010331626050174236,
-0.04389869049191475,
-0.008776064030826092,
-0.005052513908594847,
-0.002319563180208206,
-0.017552128061652184,
0.03037632629275322,
-0.01160547137260437,
-0.008580087684094906,
-0.05560827627778053,
0.007845176383852959,
-0.016290530562400818,
-0.016584495082497597,
-0.004844289273023605,
-0.017000945284962654,
0.02363964170217514,
0.03561869263648987,
0.03348745033144951,
0.033046502619981766,
0.06222247704863548,
0.016094554215669632,
0.04091005399823189,
-0.02350490726530552,
0.022598518058657646,
-0.006405975669622421,
-0.019989583641290665,
0.018372777849435806,
-0.000502954819239676,
-0.05521632358431816,
-0.03302200883626938,
-0.04154697805643082,
-0.014061300083994865,
-0.011507483199238777,
0.000011171989171998575,
-0.027167215943336487,
-0.03532472997903824,
-0.009541596285998821,
0.01766236498951912,
0.028906505554914474,
-0.021569641306996346,
-0.018629997968673706,
-0.0525706447660923,
-0.018152305856347084,
-0.04659336805343628,
0.027020232751965523,
0.002068468602374196,
0.016241535544395447,
0.026505794376134872,
-0.01218115258961916,
-0.03101325035095215,
-0.023406919091939926,
0.03549620881676674,
-0.017172424122691154,
-0.027632659301161766,
-0.011703459545969963,
-0.04419265687465668,
0.007698194123804569,
-0.009174141101539135,
-0.015151417814195156,
0.03510425612330437,
-0.012701714411377907,
-0.029420942068099976,
0.03353644534945488,
-0.02346816286444664,
0.024435795843601227,
-0.035643190145492554,
0.013240649364888668,
0.01604555919766426,
0.006320235785096884,
-0.012811951339244843,
-0.00013186296564526856,
-0.029322953894734383,
-0.024888990446925163,
-0.03681904822587967,
-0.02350490726530552,
0.01388982031494379,
-0.010711329989135265,
-0.025109464302659035,
-0.028000114485621452,
0.004636064637452364,
0.015053429640829563,
-0.010944051668047905,
-0.03498176857829094,
0.028392067179083824,
0.0027589788660407066,
-0.015028933063149452,
0.01083993911743164,
-0.010117276571691036,
0.03495727479457855,
0.0007846707594580948,
-0.05198271572589874,
0.032654549926519394,
-0.00006167320680106059,
0.04333525896072388,
-0.020785735920071602,
-0.02107970044016838,
-0.0033591564279049635,
0.017380649223923683,
-0.03405088186264038,
0.01851976104080677,
-0.0381418876349926,
-0.018703488633036613,
-0.006326360162347555,
0.0066325729712843895,
0.01932816207408905,
-0.011378874070942402,
0.04382520169019699,
0.020540766417980194,
-0.05320756509900093,
0.023578399792313576,
-0.012640471570193768,
0.012750708498060703,
-0.0261138416826725,
-0.01440425869077444,
0.03059680014848709,
0.004467647522687912,
-0.0025675958022475243,
-0.03990567475557327,
-0.017245914787054062,
0.0006690753507427871,
-0.0005653456901200116,
-0.0035275735426694155,
-0.006424348335713148,
-0.005190310068428516,
0.03789691627025604,
0.02166762948036194,
-0.020797984674572945,
0.014306270517408848,
0.022035086527466774,
0.02824508398771286,
-0.02893100120127201,
-0.020087571814656258,
-0.02128792554140091,
-0.061977505683898926,
-0.02709372341632843,
0.00791254360228777,
-0.005067824851721525,
0.023602895438671112,
0.013240649364888668,
-0.01805431768298149,
0.002402240876108408,
0.020038576796650887,
-0.01380408089607954,
-0.004776922520250082,
-0.02547691948711872,
-0.023198695853352547,
-0.016608992591500282,
0.02853904850780964,
0.009633460082113743,
-0.051639754325151443,
-0.006448845379054546,
-0.02325993776321411,
0.00013530785508919507,
0.018238045275211334,
0.017821595072746277,
0.023455914109945297,
0.007569584529846907,
-0.02858804352581501,
0.030131356790661812,
-0.014612482860684395,
-0.01860550045967102,
-0.01120127085596323,
0.0092353830114007,
-0.011384998448193073,
-0.020920470356941223,
-0.018029820173978806,
-0.0016183356055989861,
-0.0381418876349926,
0.00974982138723135,
-0.029126977548003197,
0.004752425476908684,
-0.0025262569542974234,
0.019952837377786636,
0.07745963335037231,
-0.007869673892855644,
0.03493277728557587,
-0.008371862582862377,
-0.0135713592171669,
-0.015310648828744888,
0.006479466333985329,
0.03446733206510544,
0.00915576796978712,
-0.0038368485402315855,
0.014575737528502941,
0.07848850637674332,
0.005181123502552509,
-0.01518816314637661,
-0.03478579223155975,
-0.025501416996121407,
-0.004244111943989992,
0.013963311910629272,
-0.018715737387537956,
-0.04953300952911377,
0.017331654205918312,
-0.005416907370090485,
-0.007361359894275665,
-0.02210857719182968,
-0.045980941504240036,
-0.0012126034125685692,
-0.0028600292280316353,
0.03958721458911896,
0.015984317287802696,
0.009639584459364414,
-0.029543427750468254,
-0.011801447719335556,
0.011740205809473991,
-0.016106802970170975,
-0.0009737572399899364,
0.021177688613533974,
0.003356094239279628,
0.004170620813965797,
-0.005631256382912397,
-0.02355390228331089,
-0.03547171130776405,
0.041448988020420074,
-0.0002784624230116606,
0.03792141377925873,
-0.028637036681175232,
0.03912176936864853,
-0.028147095814347267,
-0.00885567907243967,
-0.031331710517406464,
0.01783384382724762,
0.05389348417520523,
0.003631685860455036,
0.017184672877192497,
-0.018703488633036613,
-0.02265975996851921,
-0.03214011341333389,
0.017086684703826904,
-0.008396360091865063,
0.029126977548003197,
0.027510173618793488,
0.03672105818986893,
0.0060844519175589085,
0.03331597149372101,
-0.03613313287496567,
-0.021998340263962746,
0.019634375348687172,
0.023284435272216797,
-0.01779709756374359,
0.04916555434465408,
-0.028979996219277382,
0.014281773008406162,
-0.002641086932271719,
-0.015763843432068825,
-0.008041152730584145,
-0.026383310556411743,
-0.0036102510057389736,
0.01265272032469511,
-0.018397275358438492,
-0.007943164557218552,
-0.01592307537794113,
-0.021961594000458717,
0.03978319093585014,
-0.005435280501842499,
-0.015347394160926342,
0.00953547190874815,
-0.02470526285469532,
0.02616283670067787,
0.017270412296056747,
0.008212631568312645,
-0.012040293775498867,
-0.020161062479019165,
0.009143519215285778,
0.009553845040500164,
-0.022721001878380775,
0.013412128202617168,
0.022904731333255768,
-0.02679975889623165,
0.006865295115858316,
0.005594511050730944,
-0.016057807952165604,
-0.012003548443317413,
-0.039366740733385086,
0.005377099849283695,
0.0013940345961600542,
0.017993073910474777,
0.012958932667970657,
0.017270412296056747,
0.03515325114130974,
-0.0015831211348995566,
-0.0027605099603533745,
0.00907002855092287,
-0.031331710517406464,
-0.006614200305193663,
0.0064917150884866714,
-0.01749088428914547,
-0.0035122628323733807,
0.04095904901623726,
-0.0188994649797678,
0.03025384247303009,
-0.01655999757349491,
0.020234553143382072,
-0.0056496295146644115,
-0.009106773883104324,
-0.014881950803101063,
0.03422236070036888,
0.016572246327996254,
-0.020283548161387444,
-0.0100070396438241,
0.023994848132133484,
-0.026211829856038094,
-0.013510116375982761,
-0.02068774774670601,
0.0047983573749661446,
-0.04556449130177498,
-0.0024833872448652983,
0.016670234501361847,
0.01814005710184574,
0.016657985746860504,
-0.08079123497009277,
-0.014734968543052673,
0.005168875213712454,
-0.020577512681484222,
-0.022721001878380775,
0.023455914109945297,
-0.020369287580251694,
-0.01546987984329462,
-0.004406404681503773,
-0.01779709756374359,
-0.013608104549348354,
-0.020663252100348473,
0.028784019872546196,
-0.0038368485402315855,
-0.008261625654995441,
-0.025011476129293442,
-0.03169916570186615,
-0.04424165189266205,
0.0026763014029711485,
0.048871591687202454,
-0.005058638285845518,
-0.0013059983029961586,
0.005138253793120384,
0.033511947840452194,
-0.004877972882241011,
0.03596165031194687,
-0.010356122627854347,
-0.010362247005105019,
-0.03118472918868065,
0.010019288398325443,
0.01885046996176243,
0.002853904850780964,
-0.006344732828438282,
0.027510173618793488,
-0.015420885756611824,
-0.03498176857829094,
0.0369415320456028,
-0.007165383547544479,
-0.003815413685515523,
0.009112898260354996,
-0.007545087486505508,
-0.0200998205691576,
0.024888990446925163,
0.0034571446012705564,
0.025158457458019257,
-0.0016703917644917965,
-0.029126977548003197,
-0.004366597160696983,
0.021814612671732903,
-0.013399879448115826,
0.027510173618793488,
-0.02812260016798973,
-0.01716017536818981,
0.027926623821258545,
-0.0059864637441933155,
0.029494434595108032,
0.0017775662709027529,
0.03547171130776405,
0.0008642861503176391,
0.00016037904424592853,
-0.045246027410030365,
0.058694902807474136,
0.06423123180866241,
-0.0019505766686052084,
0.011305383406579494,
-0.02410508506000042,
-0.0412285141646862,
0.016364021226763725,
-0.008763815276324749,
0.018115559592843056,
-0.0056404429487884045,
0.015580115839838982,
-0.03329147398471832,
0.014441004022955894,
-0.0037143633235245943,
0.051345791667699814,
-0.011042039841413498,
-0.03177265822887421,
-0.0008987350738607347,
0.025182954967021942,
-0.025574907660484314,
-0.03289952129125595,
-0.01013564970344305,
0.0022537275217473507,
-0.022047333419322968,
-0.005622070282697678,
0.01689070835709572,
0.00908840075135231,
0.0254279263317585,
0.010098904371261597,
-0.010380620136857033,
0.016804968938231468,
0.011593223549425602,
0.013301891274750233,
-0.03343845531344414,
-0.020161062479019165,
-0.01546987984329462,
0.016327274963259697,
0.022647511214017868,
-0.004121626727283001,
0.05065987631678581,
-0.042134907096624374,
0.032409582287073135,
-0.027069227769970894,
-0.03755395859479904,
-0.013252897188067436,
0.042771827429533005,
-0.005625132471323013,
0.004902469925582409,
-0.024729760363698006,
0.014918696135282516,
0.03434484824538231,
0.009970294311642647,
-0.022843487560749054,
0.02355390228331089,
0.03378141671419144,
0.003340783528983593,
-0.001886271871626377,
0.00793704017996788,
-0.017564376816153526,
0.05624520033597946,
0.02142265997827053,
0.00823712907731533,
-0.058008987456560135,
-0.017049938440322876,
0.003591878106817603,
0.015665855258703232,
0.016462009400129318,
0.008500472642481327,
0.005475088022649288,
0.004969836678355932,
-0.004146123770624399,
0.02022230438888073,
-0.006485590711236,
-0.010545974597334862,
0.006497839465737343,
0.016694732010364532,
0.014110294170677662,
-0.04688733071088791,
0.025525914505124092,
0.0011505952570587397,
0.019720114767551422,
0.02704473026096821,
-0.01638851873576641,
0.01685396209359169,
-0.006436596624553204,
-0.037651948630809784,
0.015433133579790592,
-0.01160547137260437,
0.01779709756374359,
-0.05482437089085579,
0.007955413311719894,
0.034075379371643066,
0.03699052706360817,
-0.013007926754653454,
0.027804138138890266,
-0.00048305097152478993,
-0.04073857516050339,
0.005873165093362331,
0.02205958217382431,
-0.03481028974056244,
0.06736685335636139,
0.004835102707147598,
0.004568697419017553,
0.0487980991601944,
-0.0016458947211503983,
-0.002608934650197625,
0.01053985022008419,
0.04024863243103027,
0.03365892916917801,
0.02530544064939022,
-0.0769696906208992,
0.05448141321539879,
0.005236241966485977,
-0.025182954967021942,
0.0028967747930437326,
0.038043901324272156,
-0.0026181209832429886,
0.019916091114282608,
0.014379761181771755,
-0.05482437089085579,
0.0012072446988895535,
0.015849582850933075,
0.03485928475856781,
0.031723663210868835,
-0.01745413988828659,
0.014575737528502941,
-0.0501699335873127,
0.010790945030748844,
-0.02030804380774498,
-0.024423547089099884,
-0.029665913432836533,
0.006228371988981962,
0.038337863981723785,
0.03789691627025604,
-0.02381112053990364,
-0.046152420341968536,
0.02286798506975174,
-0.04659336805343628,
-0.016535500064492226,
-0.03473680093884468,
0.0016275219386443496,
0.02807360514998436,
-0.018703488633036613,
-0.010392867960035801,
0.016290530562400818,
0.0204427782446146,
-0.016927452757954597,
0.004446212202310562,
0.03473680093884468,
-0.037186503410339355,
0.019977334886789322,
-0.037357982248067856,
0.05570626258850098,
0.023823369294404984,
0.00002837254578480497,
-0.007269496098160744,
0.00011339448974467814,
-0.005174999125301838,
-0.015139169059693813,
-0.022708754986524582,
-0.02547691948711872,
-0.020491771399974823,
-0.007881921716034412,
0.012279140762984753,
-0.017870590090751648,
0.026726268231868744,
0.013938814401626587,
0.003100406378507614,
0.03106224350631237,
-0.024043843150138855,
0.01903419941663742,
0.008157514035701752,
0.0031233723275363445,
0.01045411080121994,
-0.005432218313217163,
-0.00636922987177968,
-0.00427779508754611,
0.03358544036746025,
-0.0016719228588044643,
0.03331597149372101,
-0.008028903976082802,
-0.012217897921800613,
-0.015163666568696499,
-0.02077348902821541,
-0.005487336311489344,
0.039538219571113586,
-0.016229286789894104,
0.01945064775645733,
-0.0002229613164672628,
-0.013497867621481419,
-0.0016229287721216679,
0.0400281585752964,
0.03664756938815117,
0.046789344400167465,
0.0020899034570902586,
-0.022635262459516525,
0.023945854976773262,
0.018287038430571556,
0.0016259908443316817,
-0.0008206507773138583,
0.020540766417980194,
0.0010265789460390806,
-0.023602895438671112,
0.03512875363230705,
-0.012028045952320099,
-0.004014451988041401,
-0.023014966398477554,
-0.015665855258703232,
0.01894845813512802,
0.024092836305499077,
0.02159413881599903,
0.003160117892548442,
0.0006882136804051697,
-0.013742838054895401,
-0.0003270737361162901,
0.028906505554914474,
-0.0008566307951696217,
0.007692069746553898,
0.007275620475411415,
-0.020761240273714066,
-0.004807543940842152,
-0.054040465503931046,
-0.016621239483356476,
0.025109464302659035,
0.009615087881684303,
-0.016670234501361847,
0.00960283912718296,
0.00204244046472013,
-0.03542271628975868,
-0.015273903496563435,
0.01015402190387249,
-0.009780442342162132,
-0.022378044202923775,
-0.0021312423050403595,
-0.03311999514698982,
-0.0053740376606583595,
-0.006650945637375116,
0.006307987496256828,
0.005475088022649288,
0.013473371043801308,
0.03527573496103287,
-0.004498268477618694,
-0.05859691649675369,
0.03191963955760002,
-0.010196891613304615,
-0.011176773346960545,
-0.030180349946022034,
0.023063961416482925,
-0.016413016244769096,
-0.010203015990555286,
-0.005521019920706749,
0.016143547371029854,
-0.007636951748281717,
0.03395289555191994,
0.022476032376289368,
-0.044315140694379807,
0.010607217438519001,
-0.01716017536818981,
0.018936211243271828,
-0.035520706325769424,
0.005870102904736996,
0.014943193644285202,
-0.01158709917217493,
-0.02343141660094261,
-0.007391981314867735,
0.004633002448827028,
-0.023823369294404984,
-0.003748046699911356,
-0.021643133834004402,
0.0010013164719566703,
-0.01469822321087122,
0.015371891669929028,
0.01771135814487934,
-0.003858283394947648,
0.029469937086105347,
0.008837306872010231,
-0.016437511891126633,
-0.003928712569177151,
0.027583664283156395,
-0.003986892756074667,
0.011776951141655445,
0.0018908651545643806,
-0.004703431390225887,
-0.0002639173180796206,
-0.016829464584589005,
0.0192424226552248,
-0.021655380725860596,
-0.04629940167069435,
-0.01096854917705059,
0.051737744361162186,
-0.020504020154476166,
-0.04049360379576683,
0.04059159383177757,
0.00037262291880324483,
-0.012046418152749538,
0.015286151319742203,
0.031601179391145706,
0.004648312926292419,
0.0020623444579541683,
-0.018250294029712677,
0.02410508506000042,
0.02657928690314293,
-0.0043114786967635155,
-0.003757233265787363,
0.024350056424736977,
-0.02142265997827053,
-0.020112067461013794,
0.008114643394947052,
0.024337807670235634,
0.02243928611278534,
0.009657957591116428,
-0.0017438828945159912,
0.022769996896386147,
-0.008622957393527031,
0.0026502732653170824,
0.03302200883626938,
0.017245914787054062,
0.004709555767476559,
0.02670177072286606,
0.009798815473914146,
0.008347366005182266,
-0.023798871785402298,
-0.03723549842834473,
-0.03182165324687958,
-0.015972068533301353,
-0.03823987767100334,
-0.03618212416768074,
0.017184672877192497,
-0.0021909538190811872,
-0.02812260016798973,
0.0032611682545393705,
0.009939673356711864,
-0.0005106101161800325,
-0.02214532159268856,
0.005049452185630798,
0.0004868786199949682,
0.011176773346960545,
-0.009817187674343586,
-0.007753312587738037,
-0.024754256010055542,
-0.00346633093431592,
0.03708851709961891,
-0.013828578405082226,
0.004124688915908337,
0.03561869263648987,
0.012615974992513657,
0.011091033928096294,
0.007373608648777008,
-0.03204212710261345,
-0.0074226027354598045,
0.0076614487916231155,
-0.0384848453104496,
0.006644821725785732,
-0.04049360379576683,
-0.0070490227080881596,
-0.002477262867614627,
-0.004951464012265205,
-0.0009615087183192372,
-0.008629081770777702,
0.00992130022495985,
-0.0021572704426944256,
-0.016608992591500282,
0.005456715356558561,
0.0005856323405168951,
0.008396360091865063,
0.013461122289299965,
0.005811922252178192,
-0.01898520439863205,
-0.008972040377557278,
-0.009051655419170856,
0.010166270658373833,
0.0028309389017522335,
-0.027583664283156395,
-0.03826437518000603,
0.014661476947367191,
0.007477720733731985,
0.012958932667970657,
-0.011250264942646027,
0.023284435272216797,
-0.010999170131981373,
-0.03209111839532852,
0.05560827627778053,
0.0022812867537140846,
0.021790115162730217,
-0.031037747859954834,
-0.0013748962664976716,
-0.007098016794770956,
-0.003855221439152956,
0.02436230517923832,
0.014049051329493523,
0.025182954967021942,
-0.020871477201581,
-0.021275676786899567,
-0.021018458530306816,
0.027534671127796173,
-0.04416815936565399,
-0.03260555863380432,
-0.0004964477848261595,
0.010288756340742111,
-0.02226780727505684,
-0.007122513838112354,
0.008543342351913452,
0.02286798506975174,
-0.004663623403757811,
-0.005156626459211111,
-0.007214377634227276,
-0.00876993965357542,
-0.03211561590433121,
-0.010411241091787815,
0.008678075857460499,
0.032875023782253265,
0.023198695853352547,
-0.007655324414372444,
0.042257390916347504,
-0.018911713734269142,
0.03498176857829094,
0.023406919091939926,
0.009168016724288464,
-0.020246801897883415,
-0.02726520411670208,
0.0010885871015489101,
0.01501668430864811,
0.006828549318015575,
-0.0030406948644667864,
0.02623632736504078,
-0.012848696671426296,
-0.02692224457859993,
0.015506625175476074,
-0.015494376420974731,
0.010607217438519001,
-0.03375691920518875,
-0.01932816207408905,
-0.02491348795592785,
0.011342128738760948,
-0.0011689680395647883,
0.004672809969633818,
-0.010141774080693722,
-0.020406031981110573,
0.016841713339090347,
-0.0021450219210237265,
0.00024382208357565105,
0.0055792005732655525,
-0.013534613884985447,
-0.012475116178393364,
-0.011164525523781776,
-0.035912659019231796,
-0.025574907660484314,
-0.001800532336346805,
0.020075323060154915,
-0.013044673018157482,
-0.0015678104246035218,
-0.02939644642174244,
0.005830294918268919,
0.02765715681016445,
-0.05849892646074295,
0.008004407398402691,
0.019695619121193886,
0.02616283670067787,
0.012530234642326832,
-0.0013618821976706386,
0.03495727479457855,
0.01098692137748003,
-0.020663252100348473,
-0.015335145406425,
-0.016670234501361847,
0.016033312305808067,
0.029763901606202126,
-0.04387419670820236,
0.033854905515909195,
0.021777866408228874,
0.0011398778297007084,
0.0031233723275363445,
0.007085768040269613,
-0.008512720465660095,
0.051394786685705185,
-0.021018458530306816,
-0.01714792661368847,
-0.007857425138354301,
-0.005735368933528662,
-0.018593251705169678,
-0.001970480429008603,
0.04404567554593086,
-0.0002512860228307545,
0.010545974597334862,
0.028979996219277382,
0.02525644563138485,
-0.0015165198128670454,
-0.009964169934391975,
0.017858341336250305,
0.01851976104080677,
-0.007685945834964514,
0.003297913819551468,
-0.0006817066459916532,
-0.006271241698414087,
-0.025525914505124092,
0.0012187276734039187,
-0.004339037928730249,
-0.034761298447847366,
0.01697644777595997,
0.030278338119387627,
0.013522365130484104,
0.0028324699960649014,
0.03076827898621559,
-0.0016872334526851773,
-0.011397247202694416,
-0.013375382870435715,
-0.00310346856713295,
0.003940960858017206,
0.012554732151329517,
-0.015224909409880638,
-0.013387631624937057,
-0.01647425815463066,
-0.006151818670332432,
-0.005429156124591827,
0.03645159304141998,
0.005190310068428516,
0.01265272032469511,
-0.024117333814501762,
-0.0009729917510412633,
-0.013375382870435715,
0.03630461171269417,
-0.01817680150270462,
0.02525644563138485,
0.0029120855033397675,
-0.03980768844485283,
-0.0493125356733799,
0.046152420341968536,
0.00011425571574363858,
0.01771135814487934,
-0.039832182228565216,
0.014857453294098377,
0.030915262177586555,
-0.01843402162194252,
0.020724494010210037,
0.00008387364505324513,
0.013167157769203186,
-0.005658815614879131,
-0.016462009400129318,
-0.033609937876462936,
-0.034369345754384995,
0.018703488633036613,
0.0003532932314556092,
-0.01565360650420189,
-0.00007042898505460471,
-0.014734968543052673,
0.027191711589694023,
-0.001479774247854948,
-0.02166762948036194,
-0.008959791623055935,
-0.03826437518000603,
0.02401934564113617,
-0.012303637340664864,
-0.007042898330837488,
0.002809504047036171,
0.010993045754730701,
-0.03353644534945488,
0.03042532131075859,
-0.024937985464930534,
-0.0013649443862959743,
0.03997916728258133,
0.023860115557909012,
-0.04884709417819977,
0.026873251423239708,
0.03855833783745766,
0.005658815614879131,
-0.002094496740028262,
-0.012677216902375221,
0.013142661191523075,
-0.026089346036314964,
0.01864224672317505,
0.023076210170984268,
-0.0021036830730736256,
-0.03263005614280701,
0.007508342154324055,
0.007685945834964514,
0.001297577517107129,
-0.0023792749270796776,
-0.04977798089385033,
0.02599135786294937,
-0.007477720733731985,
0.023835618048906326,
0.024607274681329727,
0.025574907660484314,
-0.03245857357978821,
0.010184643790125847,
-0.00447070924565196,
-0.01740514487028122,
0.002054688986390829,
-0.004593194462358952,
-0.01098692137748003,
0.007171507924795151,
0.012726210989058018,
0.007263371720910072,
0.02116544172167778,
0.012542483396828175,
0.0271427184343338,
0.03875431418418884,
-0.025844374671578407,
-0.005573076196014881,
0.004816730041056871,
-0.039317745715379715,
-0.003787854453548789,
0.007361359894275665,
0.03904827684164047,
0.009988667443394661,
0.013412128202617168,
0.024472540244460106,
-0.00594359403476119,
0.010411241091787815,
-0.05114981532096863,
0.013007926754653454,
-0.02721620909869671,
-0.023112954571843147,
0.11239241063594818,
-0.02145940437912941,
-0.008010531775653362,
0.02555041015148163,
0.0011467676376923919,
-0.033217985183000565,
0.004097129683941603,
0.020320292562246323,
0.01265272032469511,
0.004360472783446312,
0.03233608976006508,
0.019475145265460014,
0.017209168523550034,
0.009878430515527725,
-0.006712188478559256,
-0.012070915661752224,
0.008292247541248798,
0.011862690560519695,
-0.006268179509788752,
-0.014306270517408848,
-0.01762561872601509,
-0.013669347390532494,
0.002445110585540533,
0.00832286849617958,
-0.007391981314867735,
-0.020124316215515137,
-0.020797984674572945,
-0.02458277717232704,
0.010999170131981373,
0.010411241091787815,
0.01388982031494379,
0.011446241289377213,
0.00829837191849947,
-0.02163088507950306,
0.001690295641310513,
-0.028000114485621452,
-0.01229138858616352,
-0.006957158911973238,
0.020332541316747665,
-0.01113390363752842,
0.004375783260911703,
-0.009700827300548553,
-0.015947571024298668,
0.014918696135282516,
0.03076827898621559,
-0.02022230438888073,
-0.017123429104685783,
0.009945797733962536,
0.01625378429889679,
-0.024301061406731606,
-0.010411241091787815,
-0.007753312587738037,
0.01256698090583086,
-0.02401934564113617,
-0.03297301381826401,
-0.004945339635014534,
0.0028431874234229326,
-0.008365738205611706,
-0.028979996219277382,
-0.025280943140387535,
-0.023700883612036705,
0.021300174295902252,
0.005009644199162722,
0.002250665333122015,
0.020173311233520508
] | 2024-07-01 | 13 | 38948258 | [
"CAR target antigens",
"target cells",
"CAR binding",
"unique CARs",
"CAR",
"CARs",
"CAR responses",
"CAR functionality",
"CAR therapeutic activity",
"stable CAR Jurkat cells",
"specific target antigen expression",
"immune cells",
"CAR-target cell doublets",
"unique cellular binding curves",
"higher or lower CAR cell binding",
"CAR-expressing T cells",
"antigen-expressing target cells",
"specific antigens",
"Chimeric antigen receptors",
"cellular avidity",
"stable fluorescent marker expression",
"target positive and negative cells",
"differing antigen binding domains",
"-culturing stably transfected CAR Jurkat cells",
"hematological cancers",
"Jurkat",
"a Jurkat cell model",
"synthetic fusion proteins",
"actively bound cells",
"The cellular binding kinetics"
] | [
"CAR-T",
"Cell-to-cell interaction",
"Cellular avidity",
"Cellular kinetics",
"Flow cytometry",
"High throughput",
"Jurkat",
"Screening",
"T cell"
] | 0 | 10.21769/BioProtoc.5021 | [
"Shepherd",
"Bennychen",
"Ahmed",
"Weeratna",
"McComb"
] | [
"Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.\nDepartment of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.",
"Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.\nDepartment of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.",
"Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.",
"Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.",
"Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada.\nCentre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada.\nDepartment of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada."
] | [
"38948258",
"36209106",
"33494834",
"35757715",
"31213606",
"35935988",
"35222427",
"35452603",
"35490197",
"38066564",
"33521057",
"38596311",
"30505888"
] | [] | 8.283602 | 4.700205 |
38946142 | 790 | Novel OX40 and 4-1BB derived spacers enhance CD30 CAR activity and safety in CD30 positive lymphoma models. | The chimeric antigen receptor (CAR) derived from the CD30 specific murine antibody, HRS-3, has produced promising clinical efficacy with a favorable safety profile in the treatment of relapsed or refractory CD30-positive lymphomas. However, persistence of the autologous CAR-T cells was brief, and many patients relapsed a year after treatment. The lack of persistence may be attributed to the use of a wild-type immunoglobulin (Ig)G1 spacer that can associate with Fc receptors. We first identified the cysteine-rich domain (CRD) 5 of CD30 as the primary binding epitope of HRS-3 and armed with this insight, attempted to improve the HRS-3 CAR functionality with a panel of novel spacer designs. We demonstrate that HRS-3 CARs with OX40 and 4-1BB derived spacers exhibited similar anti-tumor efficacy, circumvented interactions with Fc receptors, and secreted lower levels of cytokines in vitro than a CAR employing the IgG1 spacer. Humanization of the HRS-3 scFv coupled with the 4-1BB spacer preserved potent on-target, on-tumor efficacy, and on-target, off-tumor safety. In a lymphoma mouse model of high tumor burden, T cells expressing humanized HRS-3 CD30.CARs with the 4-1BB spacer potently killed tumors with low levels of circulating inflammatory cytokines, providing a promising candidate for future clinical development in the treatment of CD30-positive malignancies. | [
0.03117724135518074,
-0.014806746505200863,
0.04202574864029884,
0.06494444608688354,
-0.04327186197042465,
-0.029613493010401726,
0.014635711908340454,
0.017250103875994682,
0.03694356605410576,
-0.0029579896945506334,
-0.008258548565208912,
-0.010775206610560417,
-0.05267878994345665,
0.0016003991477191448,
0.008655593730509281,
-0.025215448811650276,
0.02687693201005459,
-0.017176803201436996,
-0.002417396754026413,
0.029320290312170982,
0.03056640364229679,
0.016724782064557076,
-0.025606386363506317,
0.03254552185535431,
-0.029100388288497925,
0.01771434210240841,
0.012381713837385178,
0.0005253218696452677,
0.0013644624268636107,
-0.02990669570863247,
0.03530651703476906,
-0.022063517943024635,
-0.017311187461018562,
-0.018667250871658325,
-0.03936249017715454,
0.04862281307578087,
0.006933026947081089,
0.0038116376381367445,
-0.0341581366956234,
-0.011502105742692947,
0.017482222989201546,
0.028123045340180397,
0.05043089762330055,
0.02365170046687126,
-0.052874255925416946,
0.005454795900732279,
0.016150593757629395,
-0.0159551240503788,
0.025093281641602516,
-0.0034237548243254423,
-0.03017546609044075,
0.024861162528395653,
-0.011239444836974144,
0.03796977549791336,
-0.043540630489587784,
0.061523742973804474,
-0.017311187461018562,
0.01613837666809559,
-0.000022369606085703708,
-0.019974447786808014,
0.020976224914193153,
-0.043418463319540024,
-0.006444355472922325,
-0.047205667942762375,
-0.047205667942762375,
0.02817191183567047,
-0.049355823546648026,
-0.004847010597586632,
0.01081185694783926,
0.026485996320843697,
-0.0033718333579599857,
-0.012393930926918983,
0.017812076956033707,
0.007348397746682167,
0.050333164632320404,
-0.016358278691768646,
0.04410260170698166,
0.0216847974807024,
0.018435131758451462,
-0.0073728314600884914,
-0.0030572512187063694,
0.009596286341547966,
-0.009034314192831516,
-0.05580628663301468,
0.00026437893393449485,
-0.0200477484613657,
0.03647932782769203,
-0.05131050944328308,
-0.04019322991371155,
-0.0047706556506454945,
-0.002637299010530114,
-0.0005039424868300557,
-0.030517535284161568,
0.004465235862880945,
-0.022845393046736717,
-0.04139047488570213,
-0.04840291291475296,
-0.06929361820220947,
0.02687693201005459,
0.04033983126282692,
0.03547755256295204,
0.01075077336281538,
-0.029222555458545685,
-0.02420145645737648,
0.0006226744153536856,
-0.007672142703086138,
-0.04165924713015556,
-0.004468290135264397,
0.023101946339011192,
-0.01263215858489275,
0.08160813897848129,
-0.0037230660673230886,
-0.04630162566900253,
0.04774320498108864,
-0.011703682132065296,
-0.045324280858039856,
-0.04955128952860832,
-0.011758658103644848,
-0.04473787546157837,
0.01968124508857727,
-0.03611282259225845,
0.006316079292446375,
0.05947132408618927,
-0.02078075520694256,
0.0045263199135661125,
-0.008093621581792831,
0.09187024086713791,
-0.009437468834221363,
-0.05179917812347412,
-0.05409593507647514,
0.04911148548126221,
0.02201465144753456,
0.018251881003379822,
-0.021306077018380165,
-0.03479341045022011,
-0.006096177268773317,
-0.006401596590876579,
-0.04810971021652222,
-0.055757418274879456,
-0.00785539485514164,
0.004114003386348486,
-0.05150597542524338,
-0.0027335062623023987,
0.0037963667418807745,
-0.0195346437394619,
-0.05116390809416771,
-0.031152809038758278,
0.001641630893573165,
-0.012668808922171593,
0.028123045340180397,
-0.011422696523368359,
0.04151264578104019,
0.05228785052895546,
-0.004202574957162142,
-0.012174028903245926,
-0.05228785052895546,
-0.0041109491139650345,
0.035159915685653687,
-0.01922922395169735,
-0.038531746715307236,
-0.02113504335284233,
0.030884038656949997,
-0.024152589961886406,
-0.03305862843990326,
0.024543525651097298,
-0.021037308499217033,
-0.0024693182203918695,
0.0013873690040782094,
-0.08390489965677261,
-0.012900928035378456,
0.012351172044873238,
-0.03181251510977745,
-0.08473563939332962,
-0.01804419606924057,
-0.05722343176603317,
0.021306077018380165,
0.025362052023410797,
0.020340951159596443,
-0.00811194721609354,
-0.029246989637613297,
0.023040860891342163,
0.006957460660487413,
0.0362105593085289,
-0.017445573583245277,
-0.029589058831334114,
0.013523983769118786,
-0.02778097428381443,
-0.021037308499217033,
-0.03970456123352051,
0.008362391032278538,
0.015429803170263767,
0.00738504808396101,
0.045690786093473434,
0.014183690771460533,
-0.0028785807080566883,
-0.007983670569956303,
0.02675476484000683,
0.015283201821148396,
-0.0211716927587986,
-0.02614392526447773,
0.028758317232131958,
-0.016309412196278572,
-0.03247222304344177,
0.008521209470927715,
-0.029393590986728668,
0.009632936678826809,
0.002702964236959815,
0.029466891661286354,
-0.007556083146482706,
0.012479448691010475,
0.0722256451845169,
0.018459565937519073,
0.01646823063492775,
0.03660149499773979,
-0.034500207751989365,
-0.011783091351389885,
0.006578740198165178,
0.02902708761394024,
0.04759660363197327,
0.028709450736641884,
-0.01055530458688736,
0.020511986687779427,
0.003106118179857731,
0.0017408921848982573,
-0.03242335468530655,
0.012534423731267452,
-0.003176364814862609,
-0.028196346014738083,
-0.014745662920176983,
0.00553420465439558,
0.009052639827132225,
0.035892922431230545,
-0.008386824280023575,
-0.05678362771868706,
-0.04207461699843407,
0.011996885761618614,
0.01877720281481743,
-0.01369501929730177,
0.04942912235856056,
-0.022246770560741425,
-0.00002782182491500862,
0.021098392084240913,
0.06846287846565247,
0.006151152774691582,
-0.006413813680410385,
-0.021403811872005463,
-0.01607729308307171,
-0.045202113687992096,
0.03623499348759651,
-0.021611496806144714,
-0.005772432312369347,
-0.0074033732526004314,
-0.008441800251603127,
-0.004391935188323259,
-0.013963788747787476,
0.07188358157873154,
0.01507551595568657,
-0.021697014570236206,
-0.02453131042420864,
-0.05038203299045563,
-0.00022009306121617556,
-0.0008108892943710089,
-0.0007120096706785262,
0.005595288705080748,
-0.03933805599808693,
0.0059068170376122,
0.018117496743798256,
0.015747439116239548,
0.02319967932999134,
0.008454017341136932,
0.03041980043053627,
0.0017118774121627212,
0.020964007824659348,
-0.02049976959824562,
-0.042294517159461975,
0.04324742779135704,
0.009480226784944534,
0.025191016495227814,
-0.014953347854316235,
0.026217225939035416,
0.014586844481527805,
-0.0004020086780656129,
-0.011080626398324966,
0.005161592736840248,
-0.02528875134885311,
0.015967341139912605,
0.05297199264168739,
-0.019901147112250328,
0.006181694567203522,
-0.013462900184094906,
0.013914921320974827,
-0.033009760081768036,
-0.021965784952044487,
-0.027243437245488167,
-0.04490891098976135,
0.0285384152084589,
-0.015674138441681862,
-0.00900988094508648,
-0.040804069489240646,
-0.02268657460808754,
-0.016969118267297745,
0.035135481506586075,
-0.016675915569067,
-0.03154374659061432,
-0.010170475579798222,
0.028123045340180397,
0.01269324216991663,
-0.01798311062157154,
0.02250332199037075,
0.03833628073334694,
-0.005561692640185356,
-0.017812076956033707,
-0.012002994306385517,
0.02047533541917801,
0.007830960676074028,
0.0007971454178914428,
0.012277871370315552,
-0.05868944898247719,
-0.002903014188632369,
-0.032985325902700424,
-0.033107493072748184,
-0.007641600910574198,
-0.039142586290836334,
0.015808522701263428,
0.00361311505548656,
-0.06528650969266891,
0.0235295332968235,
-0.028953786939382553,
0.003762770676985383,
-0.007287313695997,
0.029369156807661057,
-0.045324280858039856,
0.03772544115781784,
-0.039924461394548416,
0.010433136485517025,
-0.014085955917835236,
-0.05644156038761139,
-0.037261202931404114,
0.0017179857240989804,
-0.009327517822384834,
0.0025273479986935854,
0.02338293194770813,
-0.06860947608947754,
0.023920470848679543,
-0.014195906929671764,
0.017445573583245277,
-0.0036986323539167643,
0.006896376609802246,
-0.00551893375813961,
0.028123045340180397,
0.008997663855552673,
0.017885377630591393,
0.008130271919071674,
-0.006896376609802246,
-0.001024683122523129,
0.018545083701610565,
0.018007544800639153,
-0.03767657279968262,
0.01240614801645279,
0.012986444868147373,
0.021525979042053223,
0.03655263036489487,
-0.04170811176300049,
-0.0030786304268985987,
0.06973342597484589,
0.06816967576742172,
-0.0029946400318294764,
0.029222555458545685,
-0.026608163490891457,
-0.036381594836711884,
-0.014647928066551685,
-0.00259759440086782,
0.01692025177180767,
0.027585506439208984,
-0.04764547199010849,
0.02677919901907444,
0.03630829229950905,
0.01308417972177267,
-0.004416368901729584,
-0.018972670659422874,
0.04649709537625313,
-0.03970456123352051,
-0.02268657460808754,
-0.04244111850857735,
-0.0026617327239364386,
0.00036879428080283105,
0.018972670659422874,
-0.003484838642179966,
-0.08111947029829025,
0.005799919832497835,
-0.03403596952557564,
-0.02726786956191063,
0.007446132134646177,
-0.007323964033275843,
0.003182473126798868,
0.04402930289506912,
0.013352949172258377,
0.04759660363197327,
0.0683162733912468,
0.029882263392210007,
-0.03420700505375862,
-0.02113504335284233,
-0.022210119292140007,
-0.039167020469903946,
0.0008376134792342782,
0.012210679240524769,
0.0037688789889216423,
0.04781650751829147,
-0.004046810790896416,
-0.02311416156589985,
-0.0047859265469014645,
-0.012247329577803612,
0.03369390219449997,
0.013279648497700691,
0.02016991563141346,
0.0011499051470309496,
-0.05565968528389931,
0.02481229603290558,
0.014831180684268475,
0.026852499693632126,
0.03393823653459549,
-0.017189020290970802,
-0.0010376634309068322,
-0.031006207689642906,
0.010995108634233475,
-0.027756541967391968,
0.00836849957704544,
0.015637489035725594,
0.014611277729272842,
-0.032618824392557144,
-0.0003220268990844488,
0.08405149728059769,
0.0230164285749197,
-0.037505537271499634,
-0.022222336381673813,
0.05590401962399483,
-0.016565963625907898,
0.016675915569067,
-0.023517316207289696,
0.05194577947258949,
-0.0017408921848982573,
-0.005115780048072338,
-0.036406029015779495,
-0.019974447786808014,
0.024885596707463264,
-0.02483673021197319,
0.0325210876762867,
0.02980896271765232,
-0.05438913777470589,
0.023480666801333427,
-0.013682802207767963,
-0.037016864866018295,
-0.010958458296954632,
0.03985116258263588,
-0.0230164285749197,
0.002788481768220663,
0.0462283231317997,
-0.06113280728459358,
-0.02129386179149151,
0.025459785014390945,
0.038018643856048584,
-0.03479341045022011,
0.02092735655605793,
-0.007281205616891384,
-0.017250103875994682,
0.0263882614672184,
0.021306077018380165,
-0.03811637684702873,
-0.003826908767223358,
-0.038018643856048584,
0.011105059646070004,
-0.013340732082724571,
0.004486615303903818,
0.019876712933182716,
-0.02814747951924801,
0.03848288208246231,
0.006780317053198814,
-0.0010521708754822612,
0.04464014247059822,
0.014281424693763256,
0.012180137448012829,
-0.009822296909987926,
-0.0058915456756949425,
-0.019840063527226448,
0.07393600046634674,
0.032887592911720276,
-0.008234115317463875,
-0.0030496155377477407,
-0.04075520485639572,
0.03403596952557564,
0.035892922431230545,
-0.003603952471166849,
-0.03103064000606537,
-0.011960235424339771,
0.0075805168598890305,
-0.02456795983016491,
0.058005306869745255,
-0.015368718653917313,
-0.01855730079114437,
0.0189238041639328,
0.019669027999043465,
0.019058188423514366,
0.021550413221120834,
0.0206585880368948,
0.05302085727453232,
0.05453573912382126,
-0.01704241894185543,
0.015209900215268135,
-0.012015210464596748,
0.0194369088858366,
-0.007904261350631714,
0.016749216243624687,
0.016785865649580956,
0.0021516818087548018,
-0.0372367687523365,
-0.03596622124314308,
-0.04046200215816498,
-0.006847509648650885,
-0.02082962356507778,
0.0043491763062775135,
-0.018911587074398994,
-0.005970954895019531,
0.014745662920176983,
0.008185247890651226,
0.01922922395169735,
-0.016517097130417824,
-0.016932466998696327,
-0.04146377742290497,
-0.04586182162165642,
-0.0683162733912468,
0.00415370799601078,
-0.02817191183567047,
0.013743885792791843,
0.043565064668655396,
-0.014110390096902847,
-0.009651262313127518,
-0.01889936998486519,
0.037505537271499634,
-0.007898152805864811,
-0.03994889557361603,
0.01601620949804783,
0.002108922926709056,
0.023517316207289696,
-0.01081185694783926,
0.025875156745314598,
0.030199898406863213,
0.022979777306318283,
-0.025117715820670128,
0.03217902034521103,
-0.0021272480953484774,
0.017421139404177666,
-0.0351843498647213,
0.007281205616891384,
-0.0023700566962361336,
0.009211458265781403,
-0.05375386402010918,
-0.00976732186973095,
-0.02150154672563076,
-0.013927137479186058,
0.004825631156563759,
-0.0103292940184474,
-0.018215229734778404,
0.022845393046736717,
0.006804750766605139,
-0.02814747951924801,
-0.00873500294983387,
-0.015222117304801941,
-0.0043491763062775135,
-0.06005772948265076,
0.023101946339011192,
-0.0000773093561292626,
0.011557080782949924,
0.011978560127317905,
-0.027829842641949654,
0.05844511091709137,
0.006926918402314186,
-0.03618612512946129,
0.024091504514217377,
0.014623494818806648,
0.02878275141119957,
-0.011587623506784439,
-0.055757418274879456,
-0.014183690771460533,
0.061768077313899994,
-0.008423475548624992,
0.03943578898906708,
-0.05619722232222557,
-0.014794529415667057,
-0.005311248358339071,
0.02387160249054432,
0.014110390096902847,
0.001985227921977639,
0.05194577947258949,
0.016333844512701035,
-0.022527756169438362,
-0.0020249325316399336,
0.0039124260656535625,
0.014159256592392921,
-0.006652040872722864,
-0.00003173501318087801,
0.010830182582139969,
-0.001777542638592422,
0.008099730126559734,
-0.0593247227370739,
-0.03755440562963486,
0.007323964033275843,
0.0012392404023557901,
-0.02954019233584404,
-0.03347399830818176,
-0.0009727617143653333,
0.04793867468833923,
0.04723010212182999,
-0.0014660145388916135,
0.006639824248850346,
-0.012491665780544281,
0.04537314921617508,
-0.04119500890374184,
-0.0210739579051733,
0.0030144923366606236,
-0.04327186197042465,
-0.01931474171578884,
0.014635711908340454,
-0.018606167286634445,
0.018752768635749817,
-0.02283317595720291,
-0.01426920760422945,
-0.018813852220773697,
0.005106617230921984,
0.0009613084839656949,
-0.010164367035031319,
0.013963788747787476,
-0.04222121834754944,
-0.03442690894007683,
-0.0037077951710671186,
0.004837847780436277,
-0.025068847462534904,
0.020182132720947266,
0.01698133535683155,
-0.01163038145750761,
0.0023853278253227472,
-0.022943127900362015,
0.026095058768987656,
-0.009889489971101284,
-0.01577187329530716,
0.06426030397415161,
-0.022307854145765305,
-0.017567740753293037,
0.0031855273991823196,
0.005570854991674423,
-0.0023715838324278593,
-0.00982840545475483,
-0.031372711062431335,
0.004709571599960327,
0.0058610038831830025,
0.03296089172363281,
-0.013523983769118786,
0.005882383324205875,
0.026070624589920044,
0.05805417522788048,
0.042294517159461975,
-0.03552641719579697,
0.0263882614672184,
-0.014379158616065979,
-0.02144046314060688,
-0.0036100607831031084,
-0.0035795187577605247,
-0.002925920533016324,
-0.004914202727377415,
0.024665694683790207,
0.010353727266192436,
0.07442466914653778,
-0.004776764195412397,
0.021904699504375458,
-0.03970456123352051,
0.0049630701541900635,
-0.006517656147480011,
0.01583295688033104,
0.005317356903105974,
-0.03371833264827728,
-0.012216787785291672,
-0.0033076952677220106,
-0.00015347338921856135,
-0.017054636031389236,
-0.08361169695854187,
-0.0016263598809018731,
0.021770315244793892,
0.0262905266135931,
-0.005485337693244219,
-0.005491446238011122,
-0.002951881382614374,
-0.0028785807080566883,
0.010274318046867847,
-0.0172867551445961,
-0.0018661143258213997,
0.024396924301981926,
-0.005799919832497835,
-0.006267211865633726,
-0.0269013661891222,
0.0018523704493418336,
0.010872941464185715,
0.036650363355875015,
-0.0083379577845335,
0.04351619631052017,
-0.0400954969227314,
0.014256991446018219,
-0.010372052900493145,
-0.012962011620402336,
-0.0372367687523365,
0.0005906053120270371,
0.07872498035430908,
-0.0036589279770851135,
-0.022026868537068367,
-0.024787861853837967,
-0.03183694928884506,
-0.0034756760578602552,
0.009504660964012146,
0.016749216243624687,
0.04312526062130928,
0.0056838602758944035,
0.02954019233584404,
-0.011550973169505596,
0.014672362245619297,
-0.005494500044733286,
-0.018398482352495193,
0.028880486264824867,
0.029760094359517097,
-0.010610279627144337,
0.03550198674201965,
-0.04058416932821274,
0.0015477142296731472,
-0.0002053947391686961,
-0.021428246051073074,
-0.025191016495227814,
-0.015429803170263767,
-0.02043868601322174,
0.03823854401707649,
-0.029760094359517097,
-0.018447348847985268,
-0.0285384152084589,
-0.009315300732851028,
0.049331389367580414,
-0.03567301854491234,
-0.03203241899609566,
0.02080518938601017,
-0.017445573583245277,
0.022552190348505974,
0.060888469219207764,
0.007079628296196461,
0.013804970309138298,
-0.02483673021197319,
-0.02344401553273201,
0.009162590838968754,
0.0033596165012568235,
-0.01749444007873535,
0.009816189296543598,
-0.023676134645938873,
0.0034451340325176716,
-0.0010666783200576901,
-0.026828065514564514,
-0.022491106763482094,
-0.017066853120923042,
0.016822516918182373,
-0.005644156131893396,
0.007409481797367334,
0.0047859265469014645,
-0.009345842525362968,
0.008857171051204205,
0.028318513184785843,
-0.007983670569956303,
0.016309412196278572,
0.009608503431081772,
-0.025093281641602516,
-0.006426030304282904,
-0.02890492044389248,
-0.006041201297193766,
0.0066764745861291885,
-0.02514214813709259,
-0.018190797418355942,
-0.01808084547519684,
0.005781594663858414,
-0.019143706187605858,
-0.0054761748760938644,
-0.01546645350754261,
-0.0017882322426885366,
-0.014696795493364334,
0.0036955783143639565,
-0.01922922395169735,
0.03486671298742294,
-0.007873719558119774,
-0.02086627297103405,
-0.025704121217131615,
0.02137937769293785,
-0.02293091081082821,
0.02905152179300785,
-0.02575298771262169,
0.04219678416848183,
0.038018643856048584,
-0.10506437718868256,
-0.01810527965426445,
0.015820739790797234,
0.004327796865254641,
-0.02538648433983326,
0.024971114471554756,
-0.02565525472164154,
-0.017396705225110054,
0.012332847341895103,
0.007146820891648531,
-0.009425251744687557,
-0.004575186874717474,
-0.013707235455513,
0.007268988527357578,
-0.0001920326321851462,
-0.037407804280519485,
-0.0269013661891222,
-0.027609940618276596,
-0.016541531309485435,
0.01106840930879116,
0.021697014570236206,
0.007055195048451424,
-0.00009095780114876106,
0.020145483314990997,
-0.012705459259450436,
0.01117836032062769,
-0.018630601465702057,
-0.005934304557740688,
-0.050235431641340256,
-0.013108612969517708,
0.01814192906022072,
0.03281429037451744,
-0.01949799247086048,
0.03403596952557564,
-0.02010883204638958,
-0.04955128952860832,
0.014696795493364334,
-0.010543087497353554,
-0.005234893411397934,
0.032007984817028046,
0.011691465973854065,
-0.004202574957162142,
0.024030420929193497,
0.0008620470762252808,
-0.03572188690304756,
-0.019766762852668762,
-0.0007669851765967906,
0.016431579366326332,
-0.007323964033275843,
0.003735282924026251,
0.027585506439208984,
-0.026437127962708473,
-0.016211677342653275,
0.03117724135518074,
-0.03320522978901863,
-0.031226109713315964,
0.005613613873720169,
-0.007293422240763903,
0.006371054798364639,
0.016126159578561783,
-0.041928015649318695,
0.018337398767471313,
0.022039085626602173,
0.010182692669332027,
0.00038750123349018395,
-0.023663917556405067,
-0.031079508364200592,
0.03283872455358505,
-0.02035316824913025,
0.009015989489853382,
-0.024396924301981926,
0.023553967475891113,
-0.03366946801543236,
0.024299191311001778,
0.013475116342306137,
0.013914921320974827,
-0.02826964668929577,
0.00748278247192502,
0.014562411233782768,
0.02350509911775589,
0.0012797084636986256,
-0.046814728528261185,
0.01871611922979355,
0.007959237322211266,
-0.03391380235552788,
-0.02675476484000683,
0.027561072260141373,
0.022820958867669106,
-0.012430581264197826,
-0.004840902052819729,
-0.03142157942056656,
-0.000004512695340963546,
0.009138157591223717,
0.0007555319461971521,
-0.010091066360473633,
-0.004443856421858072,
-0.03721233457326889,
-0.024274757131934166,
-0.00005955683809588663,
-0.013291864655911922,
0.05219011753797531,
-0.016358278691768646,
-0.01925365813076496,
-0.010482003912329674,
-0.0462283231317997,
-0.011355504393577576,
0.015246550552546978,
0.006227507721632719,
0.0017943406710401177,
0.004123165737837553,
0.011917476542294025,
0.019522426649928093,
0.013988221995532513,
0.0010743137681856751,
0.027121268212795258,
0.010775206610560417,
0.04058416932821274,
-0.016846951097249985,
0.005396766122430563,
0.01949799247086048,
0.03322966396808624,
0.023944903165102005,
0.0235295332968235,
-0.015784090384840965,
-0.010848507285118103,
0.02305307798087597,
0.026730330660939217,
0.02501998096704483,
0.004208683501929045,
0.00965737085789442,
0.030224332585930824,
0.02037760242819786,
0.00043751372140832245,
-0.016724782064557076,
-0.037285637110471725,
0.024189239367842674,
0.017482222989201546,
0.03630829229950905,
-0.009089290164411068,
0.01640714518725872,
-0.005033316556364298,
-0.0008055444341152906,
0.0023135540541261435,
-0.020243216305971146,
0.014110390096902847,
0.004932527896016836,
-0.0329364612698555,
0.03371833264827728,
-0.01140437088906765,
0.024800078943371773,
-0.04190358147025108,
0.03090847283601761,
0.025337617844343185,
0.014537977054715157,
0.030835172161459923,
0.06338069587945938,
0.007983670569956303,
-0.049844492226839066,
-0.03154374659061432,
-0.003729174379259348,
-0.03586848825216293,
0.07315412163734436,
-0.025215448811650276,
-0.033864933997392654,
0.05214124917984009,
-0.018422916531562805,
-0.010695797391235828,
-0.0005680806352756917,
0.015674138441681862,
0.03459794446825981,
0.0005638811271637678,
-0.036381594836711884,
0.03684583306312561,
-0.009590178728103638,
-0.024396924301981926,
-0.002360894111916423,
0.006658149417489767,
0.02082962356507778,
0.009565744549036026,
0.0323256216943264,
-0.01896045356988907,
-0.002939664525911212,
0.042294517159461975,
0.03391380235552788,
0.020585287362337112,
-0.0005043242708779871,
-0.01229619700461626,
-0.015368718653917313,
0.028709450736641884,
0.020059965550899506,
-0.017579957842826843,
-0.005521988030523062,
-0.012155703268945217,
0.07193244248628616,
0.050088830292224884,
-0.02501998096704483,
-0.03244778886437416,
-0.005335682071745396,
-0.049453556537628174,
-0.03432917222380638,
-0.029589058831334114,
0.027365604415535927,
0.01734783872961998,
-0.01959572732448578,
-0.025239882990717888,
0.005259327124804258,
0.02469012700021267,
-0.024433575570583344,
0.012424472719430923,
0.021574847400188446,
-0.011269986629486084,
0.0312994085252285,
-0.0016966063994914293,
0.003506218083202839,
0.029271423816680908,
-0.006444355472922325,
0.025362052023410797,
-0.0010475895833224058,
-0.01308417972177267,
-0.025875156745314598,
-0.018117496743798256,
-0.021098392084240913,
0.01949799247086048,
-0.006804750766605139,
0.007244555279612541,
-0.002805279800668359,
-0.0047645471058785915,
0.006975785829126835,
-0.007036869879812002,
0.02131829410791397,
-0.0195346437394619,
0.006239724345505238,
0.022087952122092247,
-0.002000499051064253,
0.00830741599202156,
-0.01263215858489275,
-0.01496556494385004,
-0.024848945438861847,
-0.004639325197786093,
-0.003735282924026251,
0.04036426544189453,
-0.019424691796302795,
-0.0038391256239265203,
-0.009938356466591358,
-0.017298972234129906,
-0.01173422485589981,
0.03867834806442261,
-0.058542847633361816,
-0.010378161445260048,
-0.000810125726275146,
-0.00864337757229805,
-0.0161628108471632,
0.02071967162191868,
0.03259439021348953,
0.007146820891648531,
0.009229782968759537,
-0.007012436166405678,
0.025875156745314598,
0.044053737074136734,
0.011648707091808319,
-0.010274318046867847,
0.004294200800359249,
0.017848726361989975,
-0.004666812717914581,
0.03950909152626991,
-0.004737059585750103,
-0.001563748810440302,
0.003074049251154065,
-0.019962230697274208,
0.006346621084958315,
0.04698576405644417,
0.005302086006850004,
0.02614392526447773,
0.012155703268945217,
0.0029656251426786184,
-0.0005276125157251954,
0.04940468817949295,
0.0037383369635790586,
0.018545083701610565,
0.022246770560741425,
-0.010115500539541245,
-0.005112725775688887,
-0.03384050354361534,
-0.0006180931231938303,
0.01867946796119213,
0.017298972234129906,
-0.007024652790278196,
-0.008655593730509281,
0.03506217896938324,
-0.029515758156776428,
-0.01698133535683155,
-0.01632162742316723,
0.0006833765655755997,
-0.017763208597898483,
-0.01619946025311947,
-0.005213513970375061,
0.01853286661207676,
-0.014428026042878628,
-0.0021318295039236546,
-0.012112945318222046,
0.01501443237066269,
0.0161628108471632,
0.0018340452807024121,
-0.05170144513249397,
0.02307751215994358,
-0.00617864029482007,
-0.008912147022783756,
-0.02841624803841114,
0.032007984817028046,
-0.02792757749557495,
-0.03594179078936577,
-0.011838067322969437,
0.023700568825006485,
-0.01591847464442253,
0.00976732186973095,
0.00238074641674757,
-0.02238115482032299,
0.009107614867389202,
-0.0025777420960366726,
0.019974447786808014,
-0.028000878170132637,
0.029491325840353966,
-0.015759656205773354,
0.011758658103644848,
-0.023859385401010513,
0.009162590838968754,
0.01847178302705288,
0.0016156701603904366,
-0.015209900215268135,
-0.023761652410030365,
0.0004184249846730381,
-0.010292643681168556,
0.012522207573056221,
0.02232007123529911,
-0.0349888801574707,
0.019082622602581978,
0.005082183517515659,
-0.010372052900493145,
0.025337617844343185,
0.003671144600957632,
0.002322716638445854,
0.006087014451622963,
0.0060686892829835415,
0.00308168469928205,
0.005561692640185356,
-0.010659147053956985,
-0.005610559601336718,
-0.003836071351543069,
-0.029979996383190155,
-0.02790314331650734,
0.05658816173672676,
-0.011605948209762573,
-0.03591735661029816,
0.031128374859690666,
-0.011477671563625336,
-0.013047529384493828,
0.017995327711105347,
0.005448687355965376,
0.0033871044870465994,
-0.02763437293469906,
-0.0067070163786411285,
0.024360274896025658,
0.027438905090093613,
-0.012308413162827492,
0.012729892507195473,
0.01513659954071045,
-0.004227008670568466,
0.026070624589920044,
-0.022185686975717545,
0.00999333243817091,
-0.01597955822944641,
0.007598842028528452,
-0.0013583541149273515,
-0.0118136340752244,
0.0014858668437227607,
0.005931250285357237,
0.01849621720612049,
0.022222336381673813,
-0.016370495781302452,
0.0317147821187973,
0.01871611922979355,
-0.0053937118500471115,
0.008136380463838577,
-0.022845393046736717,
-0.018569517880678177,
-0.029149254783988,
-0.01683473400771618,
-0.02086627297103405,
0.008356282487511635,
-0.04143934324383736,
-0.01659039780497551,
-0.0029915859922766685,
0.0024891705252230167,
0.026681464165449142,
-0.0235295332968235,
-0.03535538166761398,
0.0033321287482976913,
0.007330072578042746,
0.011978560127317905,
0.0024968059733510017,
-0.04637492448091507,
-0.015942908823490143,
0.025459785014390945,
-0.0068841599859297276,
-0.00662760715931654,
0.032252319157123566,
0.004251441918313503,
0.02062193676829338,
0.0026082841213792562,
-0.0037474995478987694,
-0.016504880040884018,
-0.00019833190890494734,
-0.044591274112463,
0.002492224797606468,
-0.0302731990814209,
-0.002322716638445854,
0.006316079292446375,
-0.008331849239766598,
-0.027487771585583687,
-0.013963788747787476,
-0.0060473098419606686,
-0.00974899623543024,
-0.03520878031849861,
0.01314526330679655,
0.019632378593087196,
-0.014000439085066319,
-0.0058396244421601295,
0.016492662951350212,
-0.046814728528261185,
0.03164147958159447,
0.0007795837591402233,
0.00965737085789442,
-0.0035092723555862904,
-0.0035153806675225496,
-0.0341581366956234,
0.036894697695970535,
0.005662481300532818,
0.04073077067732811,
-0.003127497620880604,
0.003274099202826619,
-0.004437748342752457,
-0.006841401103883982,
0.032350052148103714,
0.015808522701263428,
0.009278650395572186,
-0.00002334790406166576,
0.0047645471058785915,
-0.006389379967004061,
0.012509990483522415,
0.023908253759145737,
0.020964007824659348,
0.012186245992779732,
-0.04021766409277916,
-0.01288871094584465,
-0.049355823546648026,
-0.014428026042878628,
-0.024787861853837967,
-0.026950232684612274,
0.0007994360639713705,
-0.004929473623633385,
-0.05150597542524338,
0.0005226494395174086,
-0.008356282487511635,
0.06538424640893936,
0.010372052900493145,
-0.014818963594734669,
0.0029198122210800648,
0.0178975947201252,
-0.00485922722145915,
0.008252440020442009,
0.025850722566246986,
0.006074797827750444,
0.009290866553783417,
-0.006816967390477657,
0.00006342231063172221,
-0.015600837767124176,
0.00039742738590575755,
0.004682084079831839,
0.024946680292487144,
-0.0032863158266991377,
-0.049966663122177124,
0.008392932824790478,
-0.0010391904506832361,
-0.004724842496216297,
-0.000569989497307688,
0.03357173129916191,
0.008844953961670399,
-0.019998881965875626,
0.0275122057646513,
-0.01937582530081272,
0.00985894724726677,
-0.045079946517944336,
-0.005497554317116737,
-0.012076294980943203,
0.0073667229153215885,
-0.004422476980835199,
0.005995388608425856,
0.005784648936241865,
0.007721009664237499,
0.007195687852799892,
-0.02289425954222679,
-0.01962016150355339,
-0.0032343945931643248,
-0.014953347854316235,
-0.007940911687910557,
0.012283979915082455,
-0.024983331561088562,
-0.03696800023317337,
0.008967122063040733,
0.021965784952044487,
-0.026608163490891457,
-0.012852060608565807,
0.008777761831879616,
-0.002724343677982688,
0.04288092628121376,
-0.03972899168729782,
-0.006111448165029287,
0.019901147112250328,
0.0285384152084589,
0.028342947363853455,
0.014391375705599785,
0.011514322832226753,
0.019192572683095932,
0.004196466412395239,
0.0024784808047115803,
-0.03303419426083565,
-0.013792753219604492,
0.05282539129257202,
-0.03545311838388443,
0.028342947363853455,
0.009920031763613224,
-0.029955564066767693,
0.030835172161459923,
0.0071590375155210495,
-0.009889489971101284,
0.036650363355875015,
0.018459565937519073,
0.01814192906022072,
0.012283979915082455,
-0.004410260356962681,
-0.010549196042120457,
0.009877272881567478,
0.019522426649928093,
0.00847845058888197,
-0.012345063500106335,
0.04515324905514717,
0.03572188690304756,
-0.018325181677937508,
-0.04339402914047241,
0.001864587189629674,
0.021513763815164566,
-0.012546640820801258,
0.008527318015694618,
0.024274757131934166,
-0.005977063439786434,
-0.0638204962015152,
-0.00791647844016552,
0.0009910869412124157,
-0.018789419904351234,
-0.012143487110733986,
0.02563082054257393,
0.001504955580458045,
0.01883828639984131,
0.010793532244861126,
0.010830182582139969,
0.02453131042420864,
-0.025337617844343185,
-0.009028205648064613,
-0.015197684057056904,
0.004419422708451748,
-0.0034726217854768038,
-0.012815410271286964,
-0.030493101105093956,
0.0014499799581244588,
-0.0012881075963377953,
0.010701905936002731,
0.009950573556125164,
0.005097454879432917,
-0.0262905266135931,
0.012345063500106335,
-0.01968124508857727,
0.015344285406172276,
-0.026241660118103027,
0.011166144162416458,
-0.0031580396462231874,
-0.02792757749557495,
-0.011001217179000378,
0.02565525472164154,
-0.029149254783988,
0.003518434939906001,
-0.05986225977540016,
-0.0018981833709403872,
0.04769434034824371,
-0.020731888711452484,
0.001311014057137072,
0.025924023240804672,
0.02205130085349083,
0.00735450629144907,
-0.03342512995004654,
-0.0020386765245348215,
-0.022515539079904556,
0.022063517943024635,
-0.00342680886387825,
-0.005097454879432917,
0.0047309510409832,
-0.01501443237066269,
-0.014342508278787136,
-0.04139047488570213,
0.0007471329299733043,
0.012778759934008121,
-0.04197688400745392,
-0.006603173911571503,
0.0028923244681209326,
-0.02207573503255844,
-0.002495278837159276,
0.010353727266192436,
-0.029613493010401726,
0.016065075993537903,
0.020768538117408752,
0.02905152179300785,
0.023101946339011192,
0.05443800613284111,
-0.021819183602929115,
-0.0020615828689187765,
0.02041425183415413,
0.027316737920045853,
-0.015600837767124176,
-0.0028724721632897854,
0.05629495903849602,
0.006865834817290306,
0.0038971551693975925,
0.005634993314743042,
-0.006810859311372042,
-0.02262549102306366,
0.009706237353384495,
-0.025459785014390945,
0.004868390038609505,
0.0028709450270980597,
-0.006145044229924679,
0.037407804280519485,
-0.004825631156563759,
0.016908034682273865,
0.013475116342306137,
0.009034314192831516,
-0.015942908823490143,
0.0476699061691761,
-0.0005360115319490433,
-0.016052858904004097,
-0.005848787259310484,
0.011013434268534184,
-0.0011201266897842288,
0.01767769083380699,
-0.0031137538608163595,
-0.018874937668442726,
0.012088511139154434,
-0.0004745458427350968,
-0.023822735995054245,
0.03994889557361603,
-0.032227884978055954,
-0.007330072578042746,
0.03078630566596985,
-0.019876712933182716,
0.012766542844474316,
0.009840622544288635,
0.0018676414620131254,
-0.013328514993190765,
0.028367381542921066,
0.014611277729272842,
-0.018447348847985268,
-0.008032537996768951,
-0.04236781969666481,
0.0036008981987833977,
-0.005778540391474962,
0.04649709537625313,
0.08815634250640869,
-0.015539754182100296,
0.011502105742692947,
0.005244056228548288,
-0.009535202756524086,
-0.01646823063492775,
0.001965375617146492,
0.015735222026705742,
0.03555085137486458,
-0.0025487274397164583,
0.017518874257802963,
0.02346844971179962,
0.026974666863679886,
0.02043868601322174,
0.006719233002513647,
-0.005790757481008768,
0.032887592911720276,
0.028074178844690323,
0.01163038145750761,
-0.014318075031042099,
-0.0045935120433568954,
0.019082622602581978,
-0.03398710489273071,
0.013988221995532513,
-0.029149254783988,
-0.001777542638592422,
0.005674697924405336,
0.0006089305388741195,
0.01564970426261425,
-0.0008841900271363556,
0.04529985040426254,
-0.012204570695757866,
0.00850899238139391,
-0.03002886474132538,
-0.012962011620402336,
-0.02495889738202095,
0.0047645471058785915,
-0.027438905090093613,
0.005561692640185356,
0.0103292940184474,
-0.01294979453086853,
0.019363608211278915,
0.002460155636072159,
0.0372367687523365,
0.02395712025463581,
-0.0010773679241538048,
0.010201017372310162,
-0.025435352697968483,
0.0010796586284413934,
-0.01652931421995163,
-0.011453238315880299,
-0.008600618690252304,
0.03508661314845085,
-0.028978221118450165,
-0.016065075993537903,
-0.0031580396462231874,
0.004370555747300386,
-0.012644375674426556,
-0.019131489098072052,
-0.03787204250693321,
-0.008857171051204205,
-0.008820520713925362,
0.02271100878715515,
0.008570076897740364,
0.002328825183212757
] | 2024-07-01 | 56 | 38946142 | [
"HRS-3 CARs",
"humanized HRS-3 CD30.CARs",
"HRS-3 CD30.CARs",
"novel spacer designs",
"HRS-3",
"promising clinical efficacy",
"high tumor burden",
"similar anti-tumor efficacy",
"CAR",
"Fc receptors",
"low levels",
"lower levels",
"future clinical development",
"tumor",
"tumors",
"CD30",
"inflammatory cytokines",
"treatment",
"the HRS-3 CAR functionality",
"many patients",
"cytokines",
"circumvented interactions",
"Fc",
"the CD30 specific murine antibody",
"persistence",
"(Ig)G1 spacer",
"the HRS-3 scFv",
"the IgG1 spacer",
"CRD",
"target"
] | [
"CAR design",
"CD30",
"Hodgkin’s lymphoma",
"immunotherapy",
"non-Hodgkin’s lymphoma",
"spacer domain"
] | 0 | 10.1016/j.ymthe.2024.06.037
10.1016/0092-8674(92)90180-k
10.1200/JCO.2011.38.0410
10.3390/cancers13236125
10.3390/cancers12102887
10.1038/s41408-021-00459-7
10.1200/JCO.20.01342
10.1016/j.omtm.2018.12.009
10.1016/j.ebiom.2020.102931
10.1126/sciimmunol.abl3995
10.3389/fimmu.2020.01704
10.4049/jimmunol.2000768
10.1016/j.omtm.2018.01.009
10.1097/01.cji.0000161397.96582.59
10.1080/2162402X.2016.1253656
10.1038/gt.2010.91
10.1158/2326-6066.CIR-14-0127
10.1002/ijc.20098
10.1371/journal.pone.0044482
10.1158/1078-0432.CCR-21-0164
10.1172/JCI94306
10.1093/protein/gzh098
10.1016/s0167-4781(01)00235-4
10.1038/s41409-020-01134-4
10.3389/fimmu.2021.611366
10.1038/s41591-018-0041-7
10.1038/s41591-018-0036-4
10.1038/s41571-021-00476-2
10.1038/mt.2016.82
10.1002/hon.2591
10.1158/2159-8290.CD-18-0442
10.1186/s40364-020-00197-1
10.1182/blood-2016-04-703751
10.1038/s41408-022-00629-1
10.1038/s41571-019-0297-y
10.1158/1078-0432.CCR-13-0330
10.1073/pnas.0502975102
10.1002/jmr.605
10.1089/hum.2020.215
10.1182/blood-2022-157149
10.1016/j.ymthe.2017.07.013
10.1038/s41591-019-0737-3
10.1038/s41467-023-37616-4
10.3390/ijms23074056
10.3389/fimmu.2021.639818
10.1172/JCI61245
10.1186/s40425-017-0222-9
10.1182/blood-2010-07-294520
10.1002/ijc.2910550523
10.3389/fcell.2021.775599
10.1016/j.bbrc.2020.03.071
10.1158/1078-0432.CCR-17-0310
10.2165/0126839-200809060-00004
10.2165/11318560-000000000-00000 | [
"Kua",
"Ng",
"Tan",
"Tan",
"Seh",
"Wong",
"Ong",
"Rooney",
"Tan",
"Chen",
"Horak",
"Tan",
"Low"
] | [
"Tessa Therapeutics Ltd, Singapore 138673, Singapore.",
"Tessa Therapeutics Ltd, Singapore 138673, Singapore.",
"Tessa Therapeutics Ltd, Singapore 138673, Singapore.",
"Tessa Therapeutics Ltd, Singapore 138673, Singapore.",
"Tessa Therapeutics Ltd, Singapore 138673, Singapore.",
"Tessa Therapeutics Ltd, Singapore 138673, Singapore.",
"Tessa Therapeutics Ltd, Singapore 138673, Singapore.",
"Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, and Baylor College of Medicine, Houston, TX 77030, USA; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.",
"Institute for Molecular and Cellular Biology, A∗STAR Singapore 138673, Singapore.",
"Institute for Molecular and Cellular Biology, A∗STAR Singapore 138673, Singapore.",
"Tessa Therapeutics Ltd, Singapore 138673, Singapore.",
"Tessa Therapeutics Ltd, Singapore 138673, Singapore.",
"Tessa Therapeutics Ltd, Singapore 138673, Singapore. Electronic address: [email protected]."
] | [
"38946142",
"1310894",
"3876124",
"22454421",
"34885234",
"33050054",
"33824268",
"32701411",
"30666307",
"32739874",
"35930653",
"32849600",
"34099546",
"29552579",
"15838376",
"28180032",
"20555360",
"25212991",
"2152774",
"15095304",
"23028547",
"33986022",
"28805662",
"15708864",
"11418184",
"33230186",
"33708205",
"29808005",
"29808007",
"33633361",
"27112062",
"31187533",
"30135176",
"32514351",
"27207799",
"35210399",
"31848460",
"23620405",
"15905329",
"12557237",
"33287637",
"28807568",
"31959992",
"37031249",
"35409419",
"33833759",
"23023715",
"28344808",
"20889925",
"9058726",
"8244580",
"35096811",
"32216966",
"28751451",
"18989990",
"20055528"
] | [] | 8.423759 | 5.378251 |
38945932 | 791 | Activated CD4 | Objective Chimeric antigen receptor (CAR) T cell therapy is an emerging and effective therapy for relapsed or refractory diffuse large B cell lymphoma (R/R DLBCL). The characteristic toxicities of CAR T cell therapy include cytokine release syndrome (CRS) and prolonged cytopenia. We investigated the factors associated with these complications after CAR T cell therapy by analyzing lymphocyte subsets following CAR T cell infusion. Methods We retrospectively analyzed peripheral blood samples on days 7, 14, and 28 after tisagenlecleucel (tisa-cel) infusion by flow cytometry at our institution between June 2020 and September 2022. Patients Thirty-five patients with R/R DLBCL who received tisa-cel therapy were included. Results A flow cytometry-based analysis of blood samples from these patients revealed that the proportion of CD4 | [
0.028236307203769684,
0.019150491803884506,
0.05873151868581772,
0.05672360584139824,
-0.010936862789094448,
-0.02944105677306652,
0.004517809022217989,
0.0008392457966692746,
0.007504582870751619,
0.00627159746363759,
-0.01278163492679596,
-0.030595608055591583,
-0.0605386421084404,
-0.009964278899133205,
0.02753353677690029,
-0.03408436104655266,
0.032754115760326385,
-0.014657780528068542,
-0.006858285516500473,
0.04849115014076233,
0.012204359285533428,
0.02428322471678257,
0.004157011862844229,
-0.0015177015447989106,
-0.01028429064899683,
-0.020970163866877556,
0.036293067038059235,
-0.02590210549533367,
-0.0056378492154181,
-0.04086107388138771,
0.02038033865392208,
-0.021070560440421104,
-0.028286505490541458,
-0.03265371918678284,
0.005048024468123913,
0.03127327933907509,
0.04776328429579735,
0.021497242152690887,
-0.029014375060796738,
-0.04783857986330986,
-0.0021020362619310617,
0.03887825831770897,
0.015511144883930683,
0.08990440517663956,
-0.06596001237630844,
-0.025437775999307632,
0.018635962158441544,
-0.03400906175374985,
0.03423495218157768,
0.020719174295663834,
-0.029943035915493965,
-0.0027122541796416044,
-0.034937724471092224,
0.05642241612076759,
-0.049143724143505096,
0.03405926004052162,
-0.016000574454665184,
0.012210634537041187,
0.0018290852895006537,
-0.017544159665703773,
-0.004944491200149059,
-0.014695429243147373,
-0.0024738141801208258,
-0.02745823934674263,
-0.03925474360585213,
-0.019916009157896042,
-0.0440235398709774,
-0.0024863637518137693,
0.014933869242668152,
0.001141217420808971,
-0.009079541079699993,
0.0010745483450591564,
0.013729119673371315,
0.010704698041081429,
0.04332077130675316,
0.013264789246022701,
0.0008604230242781341,
-0.00815088115632534,
0.01146394107490778,
-0.01386716403067112,
0.0339086689054966,
0.0028863779734820127,
-0.0016188815934583545,
-0.03634326532483101,
-0.0021600774489343166,
-0.011752578429877758,
-0.019526975229382515,
-0.0268307663500309,
-0.01974031701683998,
0.008000287227332592,
-0.019050095230340958,
-0.0068457359448075294,
-0.04813976585865021,
0.027382943779230118,
-0.013741669245064259,
-0.018786557018756866,
0.013879713602364063,
-0.03915434703230858,
0.007247318979352713,
0.03985711559653282,
0.044902004301548004,
-0.0015326039865612984,
-0.02109565958380699,
-0.012154161930084229,
0.04751229286193848,
0.02528718113899231,
-0.05873151868581772,
-0.011357270181179047,
0.017506510019302368,
-0.01975286565721035,
0.0888502448797226,
0.0022432177793234587,
-0.01922578737139702,
0.04040929302573204,
-0.014645230956375599,
-0.015988023951649666,
-0.020166998729109764,
-0.01930108480155468,
-0.020342690870165825,
0.011972194537520409,
-0.027056656777858734,
0.037748806178569794,
0.03192584961652756,
-0.027157053351402283,
-0.011056083254516125,
-0.01522250659763813,
0.0929664745926857,
-0.04974609985947609,
-0.034561239182949066,
-0.06264695525169373,
0.0005608044448308647,
-0.03415965661406517,
0.036644451320171356,
-0.021233703941106796,
-0.05571964755654335,
0.014344044029712677,
-0.008182254619896412,
-0.014645230956375599,
-0.04477651044726372,
-0.02465970814228058,
0.004458199255168438,
0.017368465662002563,
0.007209670264273882,
-0.007636352442204952,
-0.023580454289913177,
-0.04949510842561722,
-0.0038307257927954197,
0.026855865493416786,
0.004229171201586723,
0.03415965661406517,
-0.03817548602819443,
0.07012643665075302,
0.061291612684726715,
-0.027960218489170074,
0.010447434149682522,
-0.05652281269431114,
0.00419152295216918,
0.05112653970718384,
-0.03265371918678284,
-0.059936270117759705,
-0.0024644022341817617,
-0.002465970814228058,
-0.01884930394589901,
-0.01676609180867672,
-0.0008792472071945667,
-0.040735580027103424,
0.00736026419326663,
0.029666947200894356,
-0.05933389440178871,
-0.00390602252446115,
-0.021685484796762466,
-0.04304468259215355,
-0.0796138346195221,
-0.013289888389408588,
-0.06676317751407623,
0.012693788856267929,
0.009311706759035587,
0.03543970361351967,
0.007956364192068577,
-0.028512395918369293,
0.0005780599312856793,
0.01423109881579876,
0.01723042130470276,
-0.006328070070594549,
-0.05471568927168846,
0.00044432966387830675,
-0.016552750021219254,
0.02129645086824894,
-0.018171632662415504,
-0.02464715950191021,
0.008426968939602375,
0.020882317796349525,
0.013603625819087029,
-0.013553427532315254,
-0.005615887697786093,
-0.012863206677138805,
0.003607972525060177,
0.0431450791656971,
-0.052958764135837555,
-0.015272704884409904,
0.0371464304625988,
-0.023354563862085342,
-0.04460081458091736,
0.001962423324584961,
-0.01110000628978014,
-0.0063970922492444515,
-0.008527364581823349,
0.026153095066547394,
-0.01940148137509823,
-0.023153772577643394,
0.03571579232811928,
-0.018711259588599205,
-0.026780568063259125,
0.024885598570108414,
-0.026027601212263107,
-0.008314023725688457,
-0.016364509239792824,
0.04703541472554207,
0.04116225987672806,
0.018811656162142754,
-0.005954723339527845,
-0.008257551118731499,
-0.00973838847130537,
0.031850554049015045,
-0.033657677471637726,
0.028838681057095528,
0.007008878979831934,
-0.01938893087208271,
-0.005399409215897322,
-0.031398773193359375,
-0.009361904114484787,
0.016276663169264793,
0.008263826370239258,
-0.015887629240751266,
-0.03054540976881981,
-0.0026542129926383495,
0.03287960961461067,
0.004919392056763172,
0.07976443320512772,
-0.031298376619815826,
0.01739356480538845,
0.010779994539916515,
0.03488752618432045,
-0.004605655558407307,
-0.0018526155035942793,
-0.021434495225548744,
0.023969488218426704,
-0.0536615327000618,
0.0279100202023983,
0.009857608936727047,
-0.02916496805846691,
0.021685484796762466,
-0.003281686455011368,
-0.025851907208561897,
0.024345971643924713,
0.026052700355648994,
0.061191216111183167,
-0.05416351184248924,
0.00865285936743021,
-0.021961571648716927,
0.028562594205141068,
-0.027709228917956352,
-0.022451002150774002,
-0.05908290296792984,
-0.0717327669262886,
0.013478131033480167,
0.000864344765432179,
-0.00017216303967870772,
-0.00591080030426383,
0.008772079832851887,
0.021258801221847534,
0.0017945742001757026,
0.034209854900836945,
-0.007655176799744368,
-0.048942930996418,
0.024760104715824127,
0.013678922317922115,
0.03784920275211334,
0.0010165070416405797,
0.04803936928510666,
-0.0006164927035570145,
0.012674964964389801,
-0.030696002766489983,
-0.028562594205141068,
-0.009085816331207752,
-0.004414276219904423,
0.000639238627627492,
-0.015147210098803043,
-0.02537502907216549,
-0.026755470782518387,
0.03250312805175781,
-0.004091127309948206,
-0.010158795863389969,
-0.029566550627350807,
-0.030118728056550026,
0.00811323244124651,
0.0023153771180659533,
-0.0151346605271101,
-0.04836565628647804,
0.03897865489125252,
-0.054314106702804565,
0.019175590947270393,
-0.02556326985359192,
-0.03980691730976105,
0.020543482154607773,
0.034561239182949066,
-0.002362437779083848,
-0.007228494621813297,
0.027031557634472847,
0.06661258637905121,
0.016188817098736763,
0.0180335883051157,
0.046533435583114624,
0.039003752171993256,
0.02399458736181259,
0.02936575934290886,
0.0072724176570773125,
-0.045730266720056534,
0.03998260945081711,
-0.03769860789179802,
-0.022338056936860085,
-0.028060615062713623,
0.0009890551446005702,
0.004442512523382902,
-0.011614534072577953,
-0.01146394107490778,
0.007686550263315439,
0.005810404662042856,
0.018334776163101196,
-0.03631816431879997,
0.041112061589956284,
-0.0474620945751667,
0.07128098607063293,
-0.003463653614744544,
0.04545418173074722,
-0.035213813185691833,
-0.012499271892011166,
-0.06008686125278473,
0.019175590947270393,
0.013252240605652332,
-0.008960321545600891,
0.030495211482048035,
-0.03845157474279404,
0.04394824430346489,
-0.009211311116814613,
-0.002855004509910941,
-0.018635962158441544,
0.010365862399339676,
0.016100969165563583,
0.0008337554172612727,
-0.01558644138276577,
-0.0034479668829590082,
0.01549859531223774,
0.003931121435016394,
-0.006808087229728699,
0.03295490890741348,
-0.02853749506175518,
-0.036644451320171356,
0.0011569042690098286,
0.023404762148857117,
0.02192392386496067,
0.028788484632968903,
-0.017870444804430008,
0.05095084756612778,
0.03471183404326439,
0.08302729576826096,
-0.03220193833112717,
0.05039867013692856,
-0.05039867013692856,
-0.07168257236480713,
0.0016235876828432083,
-0.026404084637761116,
0.03548990190029144,
0.010309389792382717,
-0.013327537104487419,
0.036920540034770966,
0.04020849987864494,
0.01613861881196499,
0.011143929325044155,
0.027056656777858734,
0.04076067730784416,
-0.011896897107362747,
-0.010309389792382717,
-0.021246252581477165,
0.0017161399591714144,
0.03531420975923538,
-0.01921323873102665,
-0.0019985029939562082,
-0.047261305153369904,
0.027483338490128517,
-0.00983250979334116,
-0.0029867738485336304,
0.030771300196647644,
-0.011470215395092964,
-0.019351283088326454,
0.06329952925443649,
-0.029842639341950417,
0.09271548688411713,
0.03298000618815422,
-0.0024675396271049976,
0.01883675344288349,
-0.03443574532866478,
0.0010510181309655309,
-0.045805566012859344,
-0.0029852052684873343,
0.012060040608048439,
0.042442306876182556,
-0.0028612790629267693,
0.021547440439462662,
-0.017468862235546112,
0.001778887351974845,
0.005076260771602392,
0.028135910630226135,
0.01296360231935978,
0.025224434211850166,
-0.04040929302573204,
-0.05752677097916603,
0.07474464178085327,
-0.0036016979720443487,
0.059835873544216156,
0.0453035868704319,
-0.03345688804984093,
0.010754895396530628,
-0.04332077130675316,
0.005104497075080872,
-0.008050484582781792,
0.03506321832537651,
0.01720532402396202,
0.012436524964869022,
-0.02773432806134224,
0.002920889062806964,
0.03481223061680794,
-0.010811368003487587,
-0.01656530052423477,
0.009983103722333908,
0.020355239510536194,
-0.024609509855508804,
0.026780568063259125,
-0.05057436227798462,
0.023781245574355125,
-0.003909159917384386,
0.025952303782105446,
0.015925277024507523,
-0.007818319834768772,
0.0416642390191555,
-0.03887825831770897,
0.04412393644452095,
-0.013704021461308002,
-0.041463449597358704,
0.02085721865296364,
-0.034385547041893005,
-0.025613468140363693,
-0.016866488382220268,
-0.006211987696588039,
-0.043647054582834244,
-0.02166038565337658,
-0.012925953604280949,
-0.08056759834289551,
-0.004524083808064461,
0.014758176170289516,
0.028688088059425354,
-0.04173953831195831,
0.0358663834631443,
0.0031248179730027914,
-0.006061393767595291,
0.03232743591070175,
0.016075871884822845,
-0.029943035915493965,
0.006494350731372833,
-0.015900177881121635,
-0.006801812909543514,
-0.0013035761658102274,
-0.01920068822801113,
0.005556277930736542,
0.013653823174536228,
0.053460743278265,
0.02572641335427761,
-0.0013506367104128003,
0.019790513440966606,
0.014758176170289516,
-0.016364509239792824,
0.014996616169810295,
-0.028311604633927345,
-0.0038840610068291426,
0.04404864087700844,
0.059384092688560486,
0.0007133589242585003,
-0.0122357327491045,
-0.044349826872348785,
0.03614247217774391,
-0.00430760532617569,
0.011024708859622478,
0.022061968222260475,
-0.013189492747187614,
-0.009901531971991062,
-0.01765710487961769,
-0.02119605429470539,
0.0008164998725987971,
0.010472532361745834,
0.002771864179521799,
0.0020094839856028557,
0.02735784463584423,
0.026077797636389732,
0.016916684806346893,
0.03594168275594711,
0.06134180724620819,
-0.010930588468909264,
0.050900649279356,
-0.009769761934876442,
-0.010660775005817413,
-0.0055719646625220776,
0.005954723339527845,
0.0558200404047966,
0.00030667768442071974,
-0.04578046500682831,
-0.05057436227798462,
-0.06134180724620819,
-0.05516747012734413,
0.0016643734415993094,
0.003145210910588503,
-0.019050095230340958,
-0.022978078573942184,
0.005352349020540714,
-0.009512498043477535,
0.03804999217391014,
-0.03062070719897747,
-0.011576886288821697,
-0.02547542378306389,
-0.021070560440421104,
-0.04231681302189827,
0.03789939731359482,
-0.03099719062447548,
-0.007284967228770256,
0.03305530548095703,
-0.02400713600218296,
-0.003369532758370042,
-0.020543482154607773,
0.023881642147898674,
-0.010585477575659752,
-0.023793794214725494,
-0.002767158206552267,
0.000821990252006799,
0.02094506472349167,
-0.03933003917336464,
0.019188139587640762,
-0.0032126642763614655,
0.00754223158583045,
-0.017343366518616676,
0.014218549244105816,
-0.006651218980550766,
0.03210154548287392,
-0.019777964800596237,
0.012938503175973892,
0.01423109881579876,
0.007215945050120354,
-0.024935796856880188,
-0.010547829791903496,
-0.0560208335518837,
-0.01956462301313877,
-0.029064571484923363,
-0.02091996558010578,
-0.02773432806134224,
-0.024885598570108414,
-0.03451104089617729,
-0.015975475311279297,
0.012480448000133038,
0.02708175592124462,
-0.010886665433645248,
-0.0233922116458416,
0.036117374897003174,
-0.030043430626392365,
0.002963243518024683,
0.0007788514485582709,
-0.013791867531836033,
0.028487296774983406,
-0.004182111006230116,
-0.008207353763282299,
0.011953369714319706,
-0.005816679447889328,
0.006359443999826908,
-0.04173953831195831,
-0.058028750121593475,
-0.014256197959184647,
0.04703541472554207,
-0.011947095394134521,
0.03089679405093193,
-0.03503812104463577,
0.003520126221701503,
-0.021585088223218918,
-0.007310066372156143,
0.04701031371951103,
0.024220477789640427,
0.04143834859132767,
0.008132056333124638,
-0.045077696442604065,
0.03318079933524132,
0.03609227389097214,
-0.017330817878246307,
-0.027608834207057953,
0.030219122767448425,
0.0038056266494095325,
-0.023266717791557312,
-0.023216519504785538,
-0.024145180359482765,
-0.018510468304157257,
0.043345868587493896,
-0.0005086457240395248,
0.0018165357178077102,
-0.008433244191110134,
0.02139684557914734,
0.05747657269239426,
0.03935513645410538,
-0.013515778817236423,
0.0026589189656078815,
0.037924498319625854,
0.019627371802926064,
-0.03260352462530136,
-0.024258125573396683,
0.007874792441725731,
-0.024120081216096878,
-0.015561342239379883,
0.011677281931042671,
-0.023417310789227486,
-0.011350995860993862,
0.02021719515323639,
-0.030921893194317818,
-0.015310353599488735,
-0.00793126504868269,
-0.019150491803884506,
0.0022651792969554663,
-0.003689544042572379,
-0.006732790730893612,
0.005415096413344145,
0.03355728089809418,
-0.0006011980585753918,
-0.032126642763614655,
0.02282748557627201,
-0.0034918899182230234,
-0.02074427343904972,
0.00042981933802366257,
-0.008866200223565102,
0.003043246455490589,
-0.0006286500138230622,
-0.05062456056475639,
0.02592720463871956,
-0.011959644965827465,
-0.01813398487865925,
-0.014005208387970924,
0.006946131587028503,
0.011030984111130238,
-0.017908094450831413,
-0.03446084260940552,
0.024672258645296097,
-0.011106280609965324,
0.004568006843328476,
-0.04357175901532173,
0.006431603338569403,
0.012022391892969608,
0.05853072926402092,
0.07434306293725967,
-0.03180035576224327,
0.014607583172619343,
-0.0026714683044701815,
0.014645230956375599,
-0.003234625793993473,
0.014030307531356812,
0.016728444024920464,
-0.007699099835008383,
0.02898927591741085,
0.014105604030191898,
0.07951343804597855,
0.03496282175183296,
0.005242540966719389,
-0.03559029847383499,
-0.007266142871230841,
-0.015260155312716961,
-0.010290564969182014,
-0.017255520448088646,
-0.03817548602819443,
0.02410753257572651,
-0.02001640386879444,
0.01259966753423214,
-0.026127995923161507,
-0.06264695525169373,
-0.005142145324498415,
-0.018146533519029617,
0.023869091644883156,
-0.005123320966959,
0.015260155312716961,
-0.012254557572305202,
-0.010748621076345444,
-0.0014635819243267179,
-0.020254844799637794,
-0.008859925903379917,
0.01106235757470131,
0.017632005736231804,
0.0037115057930350304,
-0.03704603388905525,
-0.00023549864999949932,
0.015912728384137154,
0.02961674891412258,
0.006670043338090181,
0.0427434928715229,
-0.02582680992782116,
0.0005219795275479555,
-0.006657493766397238,
-0.01684138923883438,
-0.037472717463970184,
0.004536633379757404,
0.00883482675999403,
0.02237570472061634,
0.00566608551889658,
-0.04470121115446091,
-0.02365574985742569,
-0.009819960221648216,
0.010704698041081429,
-0.006152377463877201,
0.036644451320171356,
0.006852010730654001,
0.012436524964869022,
-0.02300317771732807,
0.048691943287849426,
-0.04296938329935074,
-0.008753255009651184,
0.03280431404709816,
0.04176463559269905,
-0.029039474204182625,
0.03345688804984093,
-0.005411958787590265,
-0.018096335232257843,
0.00518606835976243,
-0.01042860932648182,
-0.029390858486294746,
0.0037993520963937044,
-0.025751512497663498,
0.021509790793061256,
-0.011131379753351212,
-0.007730473298579454,
-0.041112061589956284,
-0.012216908857226372,
0.02399458736181259,
-0.03360747918486595,
-0.03759821131825447,
0.024069882929325104,
-0.012530645355582237,
0.019062643870711327,
0.03082149848341942,
0.025036191567778587,
-0.019363831728696823,
-0.022325506433844566,
0.02317887172102928,
0.009750938042998314,
-0.0220117699354887,
-0.025851907208561897,
0.005678635090589523,
-0.0453035868704319,
0.011043533682823181,
0.017167674377560616,
-0.009932905435562134,
0.004411138594150543,
-0.015297804027795792,
0.0028942215722054243,
0.006051981821656227,
0.005101359449326992,
-0.0037083684001117945,
0.004411138594150543,
0.005113909021019936,
0.008828552439808846,
0.0001316713896812871,
-0.0060896300710737705,
-0.04071047902107239,
-0.019539523869752884,
0.02463460899889469,
-0.011633358895778656,
0.00545901944860816,
0.017882995307445526,
-0.023053376004099846,
0.01037213671952486,
-0.014331494458019733,
0.0011208244832232594,
-0.029692046344280243,
-0.011790227144956589,
-0.007435560692101717,
0.025349929928779602,
-0.012900855392217636,
-0.00965054240077734,
0.000034535554732428864,
0.01305144838988781,
-0.02236315608024597,
0.006964955944567919,
0.006695142015814781,
0.02881358377635479,
-0.014130703173577785,
-0.01013997197151184,
0.008997970260679722,
0.03604207932949066,
0.04696011543273926,
-0.07981462776660919,
-0.022149814292788506,
-0.013892263174057007,
0.0032659994903951883,
0.009261508472263813,
0.011758853681385517,
-0.024245575070381165,
-0.0028926527593284845,
-0.004558594897389412,
-0.023969488218426704,
0.02528718113899231,
-0.02427067421376705,
0.01967756822705269,
-0.011501588858664036,
-0.011740028858184814,
0.011714929714798927,
-0.019966207444667816,
-0.025349929928779602,
0.000956112751737237,
0.04133795574307442,
-0.004059753380715847,
0.015887629240751266,
-0.014946418814361095,
0.07474464178085327,
0.010208994150161743,
-0.009845059365034103,
-0.024082433432340622,
-0.002274591475725174,
-0.024245575070381165,
0.011714929714798927,
0.027960218489170074,
0.012154161930084229,
-0.017682204023003578,
0.013189492747187614,
-0.006475526373833418,
-0.02846219763159752,
0.01729317009449005,
-0.020166998729109764,
-0.03235253319144249,
0.007730473298579454,
0.005515492055565119,
0.014707978814840317,
0.016239013522863388,
0.03415965661406517,
0.0032440379727631807,
0.02655467763543129,
-0.046257346868515015,
0.004376627504825592,
-0.00046040868619456887,
-0.03333139047026634,
0.03431025147438049,
0.00754223158583045,
-0.007956364192068577,
-0.014419340528547764,
-0.027332745492458344,
0.0001038272530422546,
-0.0038432751316577196,
0.01721787266433239,
0.02019209787249565,
0.003924846649169922,
-0.026981361210346222,
0.05471568927168846,
0.011809051036834717,
-0.027433142066001892,
-0.014607583172619343,
-0.000954544055275619,
-0.044625915586948395,
0.03232743591070175,
-0.05190460756421089,
0.007937539368867874,
-0.007128098979592323,
-0.008960321545600891,
-0.0579785518348217,
0.03210154548287392,
-0.01399265881627798,
0.020995263010263443,
-0.018146533519029617,
-0.01115020364522934,
0.002327926689758897,
0.011250600218772888,
-0.017983390018343925,
-0.013440482318401337,
-0.027709228917956352,
0.01386716403067112,
-0.022174913436174393,
-0.011225501075387001,
0.007592429406940937,
0.014532285742461681,
-0.005788443144410849,
0.012486722320318222,
-0.013026350177824497,
0.003038540482521057,
0.006921032443642616,
0.011344720609486103,
-0.008433244191110134,
-0.011438841931521893,
-0.056322019547224045,
0.005010375753045082,
-0.015285254456102848,
-0.009474849328398705,
0.029591649770736694,
-0.0403841957449913,
0.02056858129799366,
-0.0023122397251427174,
-0.015636639669537544,
-0.03639346361160278,
0.03978182002902031,
-0.0030714827589690685,
0.015335451811552048,
-0.03471183404326439,
0.02094506472349167,
-0.02592720463871956,
0.04266819730401039,
-0.0025224434211850166,
-0.00847716722637415,
0.004891155753284693,
0.01883675344288349,
-0.011175302788615227,
0.05102614313364029,
-0.018058687448501587,
0.05112653970718384,
0.020982714369893074,
-0.010089773684740067,
-0.0016596673522144556,
-0.0012439661659300327,
0.009424651972949505,
0.007209670264273882,
0.015385650098323822,
0.013101646676659584,
0.002643232000991702,
0.02853749506175518,
-0.0032628620974719524,
-0.006205712910741568,
0.006431603338569403,
0.011068632826209068,
0.04005790874361992,
0.02012934908270836,
0.015988023951649666,
0.008621485903859138,
0.04071047902107239,
0.010949412360787392,
0.01091803889721632,
0.0027028420008718967,
-0.014281297102570534,
0.02364320121705532,
-0.00022118441120255738,
-0.03476203233003616,
0.01426874753087759,
0.0007510073482990265,
0.03277921676635742,
-0.04183993116021156,
0.0026542129926383495,
0.031674861907958984,
0.05009748414158821,
0.006444152910262346,
0.009581520222127438,
-0.0011718067107722163,
-0.0335070863366127,
-0.033030204474925995,
-0.007899891585111618,
-0.018322225660085678,
0.05908290296792984,
-0.03415965661406517,
-0.03009362891316414,
0.017368465662002563,
-0.03192584961652756,
-0.020556030794978142,
0.000170594357769005,
0.02275218814611435,
0.013038898818194866,
0.01756925694644451,
-0.06555843353271484,
0.0339086689054966,
-0.01884930394589901,
-0.06460466980934143,
-0.00506998598575592,
0.004806446842849255,
0.02981754019856453,
0.0060896300710737705,
0.007046527229249477,
-0.04578046500682831,
0.016364509239792824,
0.0009019931312650442,
0.03177525848150253,
0.023053376004099846,
0.00030746200354769826,
-0.009989378042519093,
-0.032929807901382446,
-0.006820636801421642,
0.005427645519375801,
-0.028964176774024963,
-0.04377255216240883,
0.018899502232670784,
0.06314893066883087,
0.031122684478759766,
-0.036920540034770966,
0.0016706482274457812,
0.013528328388929367,
-0.047361698001623154,
-0.031298376619815826,
-0.005408821627497673,
0.04801427200436592,
0.050975948572158813,
-0.016979433596134186,
-0.025676215067505836,
0.022990629076957703,
0.016816290095448494,
-0.04306977987289429,
0.007435560692101717,
0.024948345497250557,
0.013515778817236423,
0.0315493680536747,
0.0018447720212861896,
0.03343178704380989,
0.022902783006429672,
-0.0041036768816411495,
0.0068959337659180164,
0.008452068082988262,
-0.03137367591261864,
-0.014783275313675404,
-0.04703541472554207,
-0.04588086158037186,
0.03431025147438049,
-0.015423298813402653,
0.008640309795737267,
0.009782311506569386,
0.025249533355236053,
0.008765804581344128,
-0.005430783145129681,
0.022501200437545776,
-0.0005988450138829648,
0.02311612293124199,
0.02375614643096924,
-0.01892460137605667,
0.015059364028275013,
-0.006820636801421642,
-0.024069882929325104,
-0.009888982400298119,
-0.0029036335181444883,
-0.012480448000133038,
0.02021719515323639,
0.005016650538891554,
0.005082535091787577,
-0.03749781474471092,
-0.03169995918869972,
0.01657784916460514,
0.0360671766102314,
-0.03353218361735344,
-0.00028001004830002785,
-0.000049217451305594295,
-0.008847376331686974,
-0.0007831653347238898,
0.02112075872719288,
0.034209854900836945,
0.04540398344397545,
-0.02637898549437523,
-0.006914758123457432,
0.008207353763282299,
0.015260155312716961,
-0.01613861881196499,
-0.035565197467803955,
0.022087067365646362,
-0.015285254456102848,
0.0006486507481895387,
0.030871696770191193,
-0.0036016979720443487,
-0.002869122661650181,
-0.010899215005338192,
-0.016276663169264793,
-0.003400906454771757,
0.015009165741503239,
-0.0018306538695469499,
-0.005148420110344887,
-0.01622646488249302,
-0.018083786591887474,
-0.006265322677791119,
0.00992035586386919,
-0.0003017755225300789,
-0.010591752827167511,
0.0017239834414795041,
-0.015824882313609123,
-0.007341439835727215,
-0.01273143757134676,
-0.007881066761910915,
0.013804417103528976,
0.0034762031864374876,
0.007397912442684174,
-0.021710582077503204,
-0.015385650098323822,
-0.008847376331686974,
-0.03182545676827431,
0.04723620414733887,
-0.02193647250533104,
-0.004649578593671322,
-0.00013049488188698888,
-0.031122684478759766,
0.006638669408857822,
-0.006095904856920242,
0.009167388081550598,
0.0053868601098656654,
0.001048665028065443,
0.02954145148396492,
0.005179793573915958,
-0.017180224880576134,
0.005644124001264572,
-0.010510181076824665,
-0.008759530261158943,
-0.02029249258339405,
0.011532963253557682,
-0.024810301139950752,
-0.036293067038059235,
0.02971714548766613,
0.008734431117773056,
0.00793126504868269,
0.022589046508073807,
-0.004404863808304071,
-0.0022541985381394625,
0.019916009157896042,
0.0032158016692847013,
0.001459660241380334,
-0.02455931343138218,
-0.003052658634260297,
0.004059753380715847,
-0.024044783785939217,
-0.027307646349072456,
0.013227141462266445,
0.013139295391738415,
-0.021798430010676384,
-0.02230040729045868,
-0.002089486690238118,
0.011482764966785908,
-0.024596961215138435,
-0.0013122039381414652,
0.012762811034917831,
0.016100969165563583,
0.022689441218972206,
0.0162139143794775,
0.00555000314489007,
0.004536633379757404,
-0.019815612584352493,
-0.005615887697786093,
0.010905489325523376,
0.01160198450088501,
-0.01966501958668232,
0.03797469660639763,
-0.01386716403067112,
-0.006221399642527103,
-0.02102036215364933,
-0.019865810871124268,
-0.014130703173577785,
0.05843033269047737,
-0.021898824721574783,
-0.04384784772992134,
0.034987922757864,
-0.0017945742001757026,
-0.020556030794978142,
-0.007052802015095949,
0.010453708469867706,
-0.013277338817715645,
0.012794184498488903,
-0.006808087229728699,
0.03812528774142265,
0.03333139047026634,
-0.021246252581477165,
0.005584514234215021,
0.02600250206887722,
-0.008075583726167679,
0.018736358731985092,
0.004411138594150543,
0.014344044029712677,
0.01848536916077137,
0.018686160445213318,
-0.019050095230340958,
-0.017719851806759834,
0.007818319834768772,
0.01308909710496664,
0.043621957302093506,
0.021534889936447144,
-0.011884348466992378,
0.028236307203769684,
0.03318079933524132,
-0.023517707362771034,
-0.005885701160877943,
-0.0326286219060421,
-0.020970163866877556,
-0.03368277847766876,
-0.02301572822034359,
-0.028060615062713623,
0.013892263174057007,
-0.015071913599967957,
-0.002370281144976616,
-0.019991304725408554,
-0.0015726054552942514,
-0.0033036479726433754,
-0.042090922594070435,
0.008646585047245026,
-0.012769085355103016,
-0.0011129811173304915,
0.0031185431871563196,
0.014155802316963673,
-0.02808571420609951,
-0.01830967701971531,
-0.010133696720004082,
-0.003698956221342087,
0.025600919499993324,
0.008903848938643932,
0.0031656038481742144,
-0.01158943586051464,
0.015611540526151657,
0.0021287037525326014,
-0.04096147045493126,
-0.0027514712419360876,
-0.05843033269047737,
0.006883384194225073,
-0.019501876085996628,
-0.004059753380715847,
0.01593782752752304,
-0.007755572441965342,
-0.0156240900978446,
-0.01612606830894947,
0.026956262066960335,
0.011212951503694057,
-0.020443085581064224,
-0.0042636822909116745,
-0.023668300360441208,
0.0016549613792449236,
0.015837430953979492,
0.006676318123936653,
-0.029917936772108078,
0.029767341911792755,
0.0017914368072524667,
0.02294043079018593,
0.00573197053745389,
-0.001912225503474474,
-0.03890335559844971,
0.006983779836446047,
-0.013314987532794476,
0.025224434211850166,
-0.016151167452335358,
-0.011608259752392769,
0.0038432751316577196,
-0.008903848938643932,
0.04010810703039169,
0.014921319670975208,
0.00974466372281313,
-0.01957717351615429,
0.0010651362827047706,
-0.028512395918369293,
0.03744761645793915,
0.0008737568277865648,
0.013565977104008198,
0.01647745445370674,
-0.03418475762009621,
-0.019790513440966606,
-0.0026197019033133984,
-0.009060717187821865,
-0.011620809324085712,
-0.023705948144197464,
-0.003783665131777525,
0.003222076455131173,
-0.002902064938098192,
-0.009857608936727047,
-0.01720532402396202,
0.010070949792861938,
0.0196524690836668,
0.003416593186557293,
0.011890622787177563,
-0.0360671766102314,
-0.04256780073046684,
0.006946131587028503,
0.017079828307032585,
0.014306395314633846,
0.02129645086824894,
0.0016267250757664442,
0.04440002515912056,
-0.043898046016693115,
0.02999323233962059,
0.026529578492045403,
0.012486722320318222,
0.0037899399176239967,
-0.03398396447300911,
0.0023483196273446083,
-0.005688047036528587,
-0.029240265488624573,
0.021798430010676384,
0.013967559672892094,
-0.005176656413823366,
-0.016828838735818863,
0.02085721865296364,
0.011771402321755886,
-0.018246930092573166,
-0.007492033764719963,
-0.024521663784980774,
-0.0028989275451749563,
-0.00796891376376152,
-0.002775001572445035,
-0.007730473298579454,
-0.02100781351327896,
-0.018999896943569183,
0.00019971304573118687,
0.0039028851315379143,
-0.0337078757584095,
0.0011161185102537274,
-0.018723808228969574,
0.01612606830894947,
0.007561055477708578,
-0.01849791780114174,
-0.042442306876182556,
0.007341439835727215,
0.00842069461941719,
-0.02936575934290886,
-0.011834150180220604,
-0.014381692744791508,
-0.0030103041790425777,
0.03922964259982109,
-0.02247610129415989,
0.0012369070900604129,
0.02064387872815132,
0.03405926004052162,
0.004869194235652685,
0.00801911111921072,
0.009305431507527828,
0.03965632617473602,
-0.0030448150355368853,
-0.013390284031629562,
-0.0026149956975132227,
-0.007215945050120354,
0.044450223445892334,
-0.013854614458978176,
0.049344517290592194,
0.016628047451376915,
-0.027483338490128517,
0.01602567359805107,
-0.004414276219904423,
-0.021346649155020714,
0.04557967558503151,
-0.006808087229728699,
-0.014331494458019733,
-0.02610289677977562,
-0.01631431095302105,
-0.023618102073669434,
0.029767341911792755,
0.0057037342339754105,
-0.006136690732091665,
0.0018432034412398934,
0.029290461912751198,
0.029842639341950417,
-0.007824594154953957,
-0.03476203233003616,
-0.004087989684194326,
0.03187565505504608,
0.01659039966762066,
-0.01056037936359644,
-0.003686406882479787,
0.0015796645311638713,
-0.040735580027103424,
0.009041893295943737,
-0.009255234152078629,
-0.04224151745438576,
-0.024408718571066856,
-0.011482764966785908,
0.026479382067918777,
0.005443332716822624,
0.015900177881121635,
0.0002949125482700765,
-0.013754218816757202,
-0.004157011862844229,
-0.01858576573431492,
-0.008546189405024052,
0.0010565085103735328,
-0.014080504886806011,
0.01858576573431492,
-0.016628047451376915,
0.0030369716696441174,
-0.006619845516979694,
0.004517809022217989,
-0.0072975168004632,
-0.015988023951649666,
-0.015737034380435944,
-0.012580843642354012,
-0.03378317132592201,
-0.010259191505610943,
-0.01884930394589901,
0.004069165792316198,
-0.002588328206911683,
-0.008376771584153175,
-0.05416351184248924,
0.00883482675999403,
-0.011984744109213352,
0.006550823338329792,
-0.028587693348526955,
0.00019177158537786454,
0.001179650193080306,
0.003360120579600334,
0.01064195018261671,
0.028888879343867302,
-0.00965054240077734,
-0.018999896943569183,
-0.026429183781147003,
0.0032942357938736677,
-0.016464903950691223,
0.011683556251227856,
3.4621339750628977e-7,
-0.012800459749996662,
-0.01892460137605667,
-0.020443085581064224,
-0.017092378810048103,
-0.032377634197473526,
-0.010692148469388485,
-0.015925277024507523,
-0.025487974286079407,
0.009399552829563618,
0.008263826370239258,
-0.01685393787920475,
0.004015830345451832,
-0.004417413379997015,
-0.016264112666249275,
-0.029692046344280243,
-0.006240224000066519,
0.025224434211850166,
0.00842069461941719,
0.031950950622558594,
-0.022814936935901642,
0.002423616359010339,
0.0064378781244158745,
0.03742251917719841,
-0.024044783785939217,
-0.0010118010686710477,
0.04565497115254402,
-0.031047388911247253,
-0.0074983080849051476,
0.027056656777858734,
0.003915434703230858,
-0.043446265161037445,
0.004003280773758888,
-0.02110820822417736,
-0.008778354153037071,
0.030294420197606087,
-0.026328787207603455,
0.02519933506846428,
-0.021058009937405586,
0.014256197959184647,
0.01504681445658207,
0.026404084637761116,
-0.022438451647758484,
0.043998442590236664,
-0.008583837188780308,
-0.003046383848413825,
0.029968135058879852,
0.002318514510989189,
-0.015009165741503239,
0.014344044029712677,
0.014645230956375599,
0.02100781351327896,
0.014444439671933651,
-0.007674000691622496,
-0.015749584883451462,
0.02474755421280861,
-0.021785879507660866,
-0.019614821299910545,
0.01308909710496664,
0.014933869242668152,
-0.006381405517458916,
0.00581981660798192,
0.009914081543684006,
-0.015373100526630878,
0.025124039500951767,
0.012411425821483135,
-0.004455061629414558,
0.02064387872815132,
-0.017017081379890442,
0.01263731624931097,
-0.03177525848150253,
-0.02610289677977562,
0.12569549679756165,
0.0030699141789227724,
0.013766768388450146,
0.008232451975345612,
0.007510857656598091,
-0.00337580731138587,
0.008784628473222256,
-0.00503233727067709,
0.009073266759514809,
-0.024760104715824127,
-0.001276124268770218,
0.015636639669537544,
0.044826705008745193,
0.017431214451789856,
0.012166711501777172,
-0.04071047902107239,
0.009311706759035587,
0.03712133318185806,
-0.008169705048203468,
-0.00503233727067709,
0.009311706759035587,
0.008263826370239258,
-0.018711259588599205,
-0.003234625793993473,
-0.014946418814361095,
-0.008245001547038555,
-0.0038464125245809555,
0.009167388081550598,
0.0003739349776878953,
-0.004141325131058693,
0.009167388081550598,
0.014557384885847569,
0.004872331861406565,
-0.017418663948774338,
-0.01013997197151184,
-0.008226177655160427,
-0.005411958787590265,
-0.0034071810077875853,
0.02454676292836666,
0.017268070951104164,
0.010754895396530628,
0.004382902290672064,
-0.003051089821383357,
0.01083019282668829,
0.03378317132592201,
0.007504582870751619,
-0.034485943615436554,
-0.011777677573263645,
0.014042857103049755,
-0.006914758123457432,
-0.015348001383244991,
0.008408145047724247,
0.021785879507660866,
-0.032929807901382446,
-0.030319519340991974,
-0.010077224113047123,
0.024709906429052353,
-0.00802538637071848,
-0.01666569523513317,
-0.044525519013404846,
-0.015724485740065575,
-0.009707015007734299,
0.02075682394206524,
-0.0021867451723665,
0.019614821299910545
] | 2024-07-01 | 51 | 38945932 | [
"CAR T cell therapy",
"T cell therapy",
"CAR T cell infusion",
"peripheral blood samples",
"blood samples",
"flow cytometry",
"cytokine release syndrome",
"CAR",
"relapsed or refractory diffuse large B cell lymphoma",
"Objective Chimeric antigen receptor",
"lymphocyte subsets",
"tisa-cel therapy",
"R/R DLBCL",
"prolonged cytopenia",
"R/R",
"days",
"A flow cytometry-based analysis",
"June",
"an emerging and effective therapy",
"September",
"CD4",
"Patients Thirty-five patients",
"Results",
"Methods",
"tisagenlecleucel (tisa-cel) infusion",
"these patients",
"The characteristic toxicities",
"these complications",
"(CRS",
"days 7"
] | [
"chimeric antigen receptor T cell therapy",
"cytokine release syndrome",
"diffuse large B cell lymphoma",
"flow cytometry",
"prolonged cytopenia"
] | 0 | 10.2169/internalmedicine.2556-23 | [
"Kitamura",
"Asada",
"Ikegawa",
"Fujiwara",
"Kamoi",
"Ennishi",
"Nishimori",
"Fujii",
"Fujii",
"Matsuoka",
"Maeda"
] | [
"Department of Hematology and Oncology, Okayama University Hospital, Japan.",
"Department of Hematology and Oncology, Okayama University Hospital, Japan.",
"Department of Hematology and Oncology, Okayama University Hospital, Japan.\nDivision of Blood Transfusion, Okayama University Hospital, Japan.",
"Department of Hematology and Oncology, Okayama University Hospital, Japan.",
"Department of Hematology and Oncology, Okayama University Hospital, Japan.\nDivision of Blood Transfusion, Okayama University Hospital, Japan.",
"Center for Comprehensive Genomic Medicine, Okayama University Hospital, Japan.",
"Department of Hematology and Oncology, Okayama University Hospital, Japan.",
"Division of Clinical Laboratory, Okayama University Hospital, Japan.",
"Division of Blood Transfusion, Okayama University Hospital, Japan.",
"Department of Hematology and Oncology, Okayama University Hospital, Japan.",
"Department of Hematology and Oncology, Okayama University Hospital, Japan."
] | [
"38945932",
"30501490",
"29226797",
"32888407",
"33098993",
"31135530",
"30809033",
"31793821",
"32780846",
"32732355",
"33529419",
"34166502",
"34666344",
"25317870",
"25444722",
"28924019",
"28506444",
"30804212",
"29808007",
"29808005",
"33020644",
"7165009",
"14504078",
"25113753",
"30592986",
"10877287",
"30784578",
"16818676",
"3930598",
"10537110",
"16382236",
"34503088",
"35583610",
"36097221",
"37122702",
"37019669",
"32474413",
"8608650",
"23575983",
"27111235",
"27076371",
"33264547",
"2523712",
"32728035",
"18566595",
"30038616",
"33035333",
"30782611",
"31907409",
"34500492",
"27605551"
] | [] | 6.024622 | 4.826933 |
38943466 | 792 | Small molecule-regulated switches to provide functional control of CAR T cells within the patient. | CAR T cells have generated great excitement due to their remarkable clinical response rates in selected hematologic malignancies. However, these engineered immune cells are living drugs which are hard to control after administration.
We discuss small molecule-regulated switch systems which can potentially be used to control CAR T cell function within the patient, as well as the most important obstacles in the CAR T cell field, which might be overcome with those switch systems.
There is an urgent need to develop advanced switch systems. Once available, we expect that they will open up new avenues for future CAR T cell generations. | [
0.026567557826638222,
0.03172352537512779,
0.006444960366934538,
0.04055550694465637,
-0.0502706877887249,
-0.01892908662557602,
0.0012464731698855758,
0.006647856906056404,
0.010640151798725128,
-0.02613789401948452,
0.018905216827988625,
-0.03076871670782566,
-0.05537891760468483,
0.0040519703179597855,
0.017819121479988098,
-0.08555088192224503,
0.02893071062862873,
0.01599304936826229,
0.05590406060218811,
-0.004529374651610851,
-0.004392120987176895,
0.01125480979681015,
0.008133778348565102,
0.008927463553845882,
-0.0393381267786026,
-0.011577057652175426,
-0.007525087799876928,
-0.004043018911033869,
-0.009786791168153286,
-0.002452665474265814,
0.07118100672960281,
-0.02402537874877453,
-0.027522366493940353,
-0.040054235607385635,
0.005725869908928871,
0.040412288159132004,
0.01238864567130804,
-0.006701564881950617,
-0.01713882014155388,
-0.01149351242929697,
0.017544614151120186,
0.027737198397517204,
0.01894102245569229,
0.06063036620616913,
-0.0419638529419899,
0.013880535028874874,
-0.06478378176689148,
-0.06263546645641327,
-0.033155739307403564,
-0.000055899214203236625,
-0.0537557415664196,
-0.012555737048387527,
-0.030792588368058205,
0.0105983791872859,
-0.010484995320439339,
0.032009970396757126,
-0.01857103407382965,
0.02281993255019188,
0.009709212929010391,
-0.003884878708049655,
-0.013737313449382782,
-0.0119649488478899,
-0.0074296067468822,
-0.026066282764077187,
-0.04179675877094269,
0.0007854794966988266,
-0.06354252994060516,
0.0003826695028692484,
0.014238587580621243,
0.03661692142486572,
0.008032330311834812,
0.003156837075948715,
-0.010962399654090405,
0.017067208886146545,
0.04122387617826462,
-0.006110777147114277,
-0.014966629445552826,
0.02397763915359974,
0.018654579296708107,
-0.002316903555765748,
0.032057709991931915,
-0.017449133098125458,
-0.01783105731010437,
-0.05265771225094795,
-0.01761622354388237,
-0.0158378928899765,
0.013868599198758602,
-0.03377636522054672,
-0.033203478902578354,
-0.04664241522550583,
-0.005552810616791248,
0.02008679322898388,
-0.06101229041814804,
0.03456408157944679,
-0.0032732042018324137,
-0.018857475370168686,
-0.011147393845021725,
-0.020492585375905037,
0.015551449730992317,
0.0673140287399292,
0.02456245943903923,
-0.01656593382358551,
-0.015599190257489681,
-0.011469641700387001,
0.05528343468904495,
0.022748323157429695,
-0.018630709499120712,
0.022103825584053993,
0.006409154739230871,
-0.021160952746868134,
0.013546351343393326,
-0.0391232967376709,
-0.011135458946228027,
0.050986796617507935,
-0.01122497208416462,
-0.06960556656122208,
-0.005242497660219669,
0.006421090103685856,
0.012281229719519615,
0.0019812285900115967,
-0.012317035347223282,
0.041152264922857285,
0.01897682622075081,
-0.01503824070096016,
-0.02924102358520031,
-0.02902619168162346,
0.05633372440934181,
-0.03155643492937088,
-0.03919490426778793,
-0.02907393127679825,
0.01464438159018755,
-0.003908749204128981,
0.021817384287714958,
-0.014214717783033848,
-0.07141970843076706,
0.02203221619129181,
-0.012042527087032795,
-0.00893939845263958,
-0.02671077847480774,
0.01613627001643181,
0.023846352472901344,
-0.013761183246970177,
-0.014775668270885944,
0.034468602389097214,
-0.003392555518075824,
-0.04974554479122162,
-0.0028629349544644356,
0.030315183103084564,
-0.015766281634569168,
0.056572429835796356,
0.0005214152042753994,
0.049411360174417496,
0.06497474759817123,
0.0007284147432073951,
0.031890619546175,
-0.04821785166859627,
0.02334507741034031,
0.0729951411485672,
-0.023583780974149704,
-0.02761784754693508,
-0.006725435145199299,
0.011720279231667519,
-0.013140557333827019,
-0.017711704596877098,
-0.011511415243148804,
-0.0240373145788908,
-0.007644438650459051,
0.009924044832587242,
-0.04396894946694374,
-0.0020259851589798927,
-0.023547975346446037,
-0.07547764480113983,
-0.0703694149851799,
0.0012240948854014277,
-0.028620397672057152,
0.00804426521062851,
-0.012663153000175953,
0.025899192318320274,
-0.02866813726723194,
-0.010956432670354843,
0.028787488117814064,
0.04208320379257202,
-0.012036560103297234,
-0.02388215810060501,
0.01283024437725544,
-0.018594903871417046,
-0.011219005100429058,
0.004272769670933485,
-0.04532955214381218,
-0.07137196511030197,
-0.005904896184802055,
0.005203708540648222,
0.02487277239561081,
0.00930938683450222,
0.002718221629038453,
-0.003875927533954382,
0.030434533953666687,
0.004213094245642424,
-0.013188297860324383,
-0.06812561303377151,
0.019633257761597633,
-0.009983720257878304,
-0.028739748522639275,
-0.014620511792600155,
-0.030530015006661415,
-0.01897682622075081,
-0.03487439453601837,
0.06058262661099434,
-0.01613627001643181,
-0.005373783875256777,
0.02482503093779087,
-0.022211242467164993,
-0.01075353566557169,
0.023631520569324493,
-0.04003036394715309,
-0.025469528511166573,
-0.0014717484591528773,
0.031890619546175,
0.046618543565273285,
0.04912491887807846,
-0.015611126087605953,
-0.002600362291559577,
-0.0008444091072306037,
0.030410664156079292,
-0.029264893382787704,
0.01766396500170231,
0.002800275571644306,
-0.014823408797383308,
0.0038878624327480793,
0.0017216397682204843,
0.004893395584076643,
0.004914282355457544,
0.01787879690527916,
-0.0633993148803711,
-0.0386936329305172,
-0.012615412473678589,
0.02671077847480774,
-0.01793847233057022,
0.062301281839609146,
-0.026806259527802467,
0.00511419540271163,
0.024466978386044502,
-0.025588879361748695,
-0.024073120206594467,
-0.028381694108247757,
0.0031001451425254345,
-0.00973308365792036,
-0.047835927456617355,
0.021268367767333984,
0.004505504388362169,
0.029527464881539345,
0.02176964282989502,
0.04497149959206581,
0.025755969807505608,
0.020098727196455002,
0.03396732732653618,
0.08125423640012741,
-0.027474626898765564,
0.0343015119433403,
-0.0002786102704703808,
-0.03721367567777634,
0.02056419663131237,
-0.031269993633031845,
-0.04680950567126274,
-0.03690336272120476,
0.023965703323483467,
0.021053535863757133,
0.0060898903757333755,
0.01676883175969124,
-0.009661472402513027,
0.01993163675069809,
0.01624368689954281,
0.005949653219431639,
-0.003977376036345959,
-0.07013071328401566,
0.004487602040171623,
0.01420278288424015,
0.047668833285570145,
-0.00786523800343275,
0.05007972568273544,
0.01593337394297123,
0.012746699154376984,
0.047310780733823776,
-0.0054513621143996716,
0.0004553991020657122,
-0.006301738787442446,
-0.013104752637445927,
-0.006367382127791643,
0.022282853722572327,
-0.022951219230890274,
0.009745018556714058,
-0.004950087517499924,
-0.037094324827194214,
-0.03002873994410038,
0.0031240154057741165,
-0.0017216397682204843,
-0.023213792592287064,
-0.0030911939684301615,
-0.025421787053346634,
0.0023691195528954268,
-0.0026510865427553654,
0.003780446480959654,
-0.001054765423759818,
-0.04599791765213013,
0.02582758106291294,
0.003962457180023193,
-0.010246292687952518,
-0.01315249316394329,
0.011314485222101212,
0.03902781382203102,
-0.012746699154376984,
-0.026806259527802467,
0.055569879710674286,
0.010837080888450146,
-0.007739919703453779,
0.0076623414643108845,
-0.0011420409427955747,
-0.08335481584072113,
0.03967231139540672,
-0.06697984784841537,
-0.05194160342216492,
0.004595017991960049,
-0.048361070454120636,
-0.003061356022953987,
0.01804588921368122,
-0.029384244233369827,
-0.016339167952537537,
-0.011469641700387001,
0.047621093690395355,
-0.022127697244286537,
-0.0005859393859282136,
-0.007274450268596411,
0.017449133098125458,
-0.00008741537021705881,
-0.01020452007651329,
-0.043992821127176285,
-0.04917265847325325,
-0.03313186764717102,
0.012973465956747532,
0.02745075710117817,
0.024383433163166046,
0.009912109933793545,
-0.037356898188591,
0.034420862793922424,
-0.006528506055474281,
-0.0018827638123184443,
-0.0013203216949477792,
0.006779143121093512,
0.016327232122421265,
0.015814023092389107,
-0.016697220504283905,
0.025469528511166573,
-0.011923176236450672,
0.03640209138393402,
-0.01567080058157444,
0.02897845022380352,
-0.03819235786795616,
-0.013140557333827019,
-0.0005874312482774258,
-0.021172886714339256,
0.025946931913495064,
0.039624568074941635,
-0.03972005099058151,
0.07218355685472488,
0.035160839557647705,
0.06616825610399246,
-0.030124220997095108,
0.01861877366900444,
0.008975204080343246,
-0.04012584313750267,
0.001960342051461339,
-0.01820104569196701,
0.0013486675452440977,
-0.008127810433506966,
-0.010097104124724865,
0.02919328212738037,
0.02649594657123089,
0.015575320459902287,
0.02850104682147503,
0.015109851025044918,
0.03707045689225197,
-0.010538703761994839,
-0.032582852989435196,
-0.030315183103084564,
-0.012102202512323856,
0.020003246143460274,
0.007393801584839821,
-0.0006780635449104011,
-0.06072584539651871,
0.007477347273379564,
-0.013820858672261238,
-0.008217324502766132,
0.014477290213108063,
-0.0009279549121856689,
-0.016864312812685966,
0.06363801658153534,
-0.015599190257489681,
0.09576733410358429,
0.034373119473457336,
-0.004893395584076643,
0.005892961286008358,
-0.06449734419584274,
-0.029431983828544617,
-0.014966629445552826,
0.026782389730215073,
-0.0183562021702528,
0.049936506897211075,
-0.0028674104250967503,
0.014214717783033848,
-0.01647045463323593,
0.030315183103084564,
0.028572656214237213,
0.056190505623817444,
-0.004401072394102812,
0.016064660623669624,
-0.03881298378109932,
-0.04435087367892265,
0.016422713175415993,
-0.03274994716048241,
0.04339606687426567,
0.009625667706131935,
-0.031747397035360336,
0.00152545643504709,
-0.011893338523805141,
-0.012507996521890163,
0.0124602559953928,
0.013295713812112808,
-0.006516570691019297,
-0.020218078047037125,
-0.043777987360954285,
-0.016279492527246475,
0.03812074661254883,
-0.006803013384342194,
-0.0047203367576003075,
0.00634947931393981,
0.05795690044760704,
-0.027164313942193985,
-0.0040489863604307175,
0.0047143688425421715,
0.024216340854763985,
-0.0060272314585745335,
0.04387347027659416,
0.0038371384143829346,
0.024216340854763985,
0.03265446424484253,
0.017126884311437607,
-0.024490848183631897,
-0.0030538965947926044,
0.0014926348812878132,
-0.0312461219727993,
-0.0050246817991137505,
-0.016219817101955414,
-0.007698147092014551,
-0.002454157220199704,
-0.07103778421878815,
0.021805448457598686,
0.04965006187558174,
-0.07146744430065155,
0.004669612273573875,
0.0624922439455986,
0.0264482069760561,
-0.047621093690395355,
0.01715075597167015,
-0.011994786560535431,
-0.013558286242187023,
0.04454183578491211,
0.042465128004550934,
-0.024120859801769257,
-0.020003246143460274,
-0.03637821972370148,
0.03351379185914993,
0.00991807784885168,
-0.03644983097910881,
-0.004135516006499529,
-0.014071496203541756,
0.011004172265529633,
0.022151567041873932,
0.0020364283118396997,
0.01078337337821722,
-0.0031359505373984575,
-0.0013389702653512359,
0.018380071967840195,
0.005215643905103207,
0.006832851096987724,
0.054615069180727005,
0.028835229575634003,
-0.023476364091038704,
-0.0017962342826649547,
-0.05838656425476074,
0.01909617893397808,
0.009118424728512764,
-0.0035566631704568863,
0.010061298497021198,
-0.011469641700387001,
-0.013785053975880146,
-0.04048389941453934,
0.0005736313178204,
-0.022688645869493484,
-0.044303134083747864,
0.0007343823090195656,
0.007053650915622711,
0.016231751069426537,
-0.023010894656181335,
0.022163501009345055,
0.05485377088189125,
0.03007648140192032,
0.026806259527802467,
0.052084825932979584,
0.004592034034430981,
-0.006564311217516661,
-0.03203383833169937,
-0.018690384924411774,
0.014369874261319637,
-0.02814299240708351,
-0.04077034071087837,
-0.008915528655052185,
-0.03277381509542465,
-0.009392932988703251,
-0.0019394556293264031,
0.017162689939141273,
-0.001893207081593573,
-0.017007533460855484,
0.015444033779203892,
-0.016649480909109116,
0.00015077402349561453,
-0.03193835914134979,
-0.0031120802741497755,
0.0029032158199697733,
-0.029599076136946678,
-0.0054274918511509895,
0.02271251752972603,
-0.018212979659438133,
0.005502086132764816,
0.03821622580289841,
-0.008300869725644588,
-0.023321207612752914,
-0.03370475396513939,
0.03246350213885307,
-0.035160839557647705,
-0.02592306211590767,
0.003106112824752927,
-0.007763789966702461,
0.03745238110423088,
-0.0014232620596885681,
-0.023177986964583397,
0.03143708407878876,
-0.014429549686610699,
-0.020110663026571274,
0.007232677657157183,
-0.0086827939376235,
0.040579378604888916,
-0.009375030174851418,
0.0031598208006471395,
-0.014107301831245422,
0.009780824184417725,
-0.05423314496874809,
-0.008247162215411663,
-0.04554438591003418,
0.00474719051271677,
-0.012340905144810677,
-0.002601854270324111,
-0.045257940888404846,
0.025015993043780327,
-0.006337543949484825,
-0.03243963420391083,
0.028882969170808792,
-0.0003287750296294689,
-0.031150640919804573,
-0.02902619168162346,
0.028310084715485573,
0.014322133734822273,
0.022497685626149178,
-0.0070178452879190445,
-0.04559212550520897,
0.04053163900971413,
0.005672161467373371,
-0.01888134703040123,
-0.007155099418014288,
-0.017067208886146545,
0.05007972568273544,
-0.0025585894472897053,
-0.030482275411486626,
-0.005012746900320053,
0.048719123005867004,
-0.022497685626149178,
0.02976616844534874,
-0.05194160342216492,
0.006319641601294279,
-0.024944383651018143,
0.005943685304373503,
0.02745075710117817,
0.014298263005912304,
0.012507996521890163,
0.03554276004433632,
-0.02819073386490345,
0.011147393845021725,
0.023166051134467125,
0.0014851754531264305,
-0.017067208886146545,
0.00799055676907301,
-0.006785111036151648,
-0.029599076136946678,
-0.02582758106291294,
-0.045043110847473145,
-0.02451471798121929,
0.047358520328998566,
-0.024992123246192932,
0.005821350496262312,
-0.01411923673003912,
0.021638356149196625,
0.03707045689225197,
0.015861762687563896,
0.00010471195128047839,
-0.017329782247543335,
0.04029293730854988,
0.024968253448605537,
-0.03033905290067196,
-0.014918888919055462,
-0.001376267522573471,
-0.03339444100856781,
-0.013641832396388054,
0.01183366309851408,
-0.04081808030605316,
-0.0007056634640321136,
-0.015491774305701256,
-0.021471265703439713,
-0.008903592824935913,
-0.013880535028874874,
-0.007495250087231398,
0.005018714349716902,
-0.004642758518457413,
-0.041844502091407776,
-0.01522920187562704,
0.03492213413119316,
-0.010264195501804352,
-0.04232190549373627,
0.03274994716048241,
0.008766339160501957,
-0.007793627679347992,
-0.002112514805048704,
-0.0010584951378405094,
0.011726247146725655,
0.0016888182144612074,
-0.00010368628136347979,
0.01841587759554386,
-0.0010115007171407342,
-0.024634070694446564,
0.008563442155718803,
0.02525469660758972,
0.021960604935884476,
0.028214603662490845,
-0.04117613285779953,
0.018057823181152344,
-0.027952030301094055,
0.010473060421645641,
-0.00893939845263958,
0.011403999291360378,
-0.01613627001643181,
0.07065586000680923,
0.06349479407072067,
-0.04122387617826462,
0.04886234551668167,
-0.030052609741687775,
-0.027546236291527748,
-0.004344380460679531,
-0.007871205918490887,
0.004848639015108347,
-0.013319584541022778,
0.00841425359249115,
0.015694672241806984,
0.06535667181015015,
0.034635692834854126,
-0.01457277126610279,
-0.006797045934945345,
-0.03432537987828255,
-0.004878476727753878,
0.030911939218640327,
-0.02050452120602131,
-0.04561599716544151,
0.05012746900320053,
-0.00783540029078722,
0.0052723353728652,
-0.01935875043272972,
-0.02671077847480774,
-0.00425785081461072,
-0.009691310115158558,
0.01186350081115961,
0.026281114667654037,
0.013868599198758602,
-0.009727115742862225,
0.025015993043780327,
-0.0015232185833156109,
-0.050986796617507935,
-0.01767590083181858,
0.01078337337821722,
-0.013283778913319111,
0.02613789401948452,
0.000052029627113370225,
0.0066418894566595554,
-0.05060487240552902,
0.034516341984272,
-0.007316223345696926,
0.008951333351433277,
0.005970539525151253,
0.013486675918102264,
-0.01457277126610279,
0.007996524684131145,
-0.007161066867411137,
-0.018284590914845467,
0.025803711265325546,
-0.0007727984921075404,
-0.003983343485742807,
-0.025469528511166573,
-0.011260777711868286,
-0.02040904015302658,
-0.007823465391993523,
0.011756084859371185,
0.03329896181821823,
0.0537557415664196,
0.037738822400569916,
-0.010401449166238308,
0.04191610962152481,
-0.0070655858144164085,
0.0015202348586171865,
0.017580419778823853,
0.021733837202191353,
-0.011362225748598576,
0.059771038591861725,
-0.03843105956912041,
0.007256547920405865,
0.005770626477897167,
-0.027021091431379318,
-0.0012927217176184058,
-0.026281114667654037,
0.0007623552228324115,
0.014632446691393852,
-0.054567329585552216,
-0.024968253448605537,
-0.0154082290828228,
0.0010450681438669562,
0.00634947931393981,
0.0073758987709879875,
-0.028835229575634003,
0.039839401841163635,
-0.013259909115731716,
0.023118311539292336,
0.05237126722931862,
0.04330058395862579,
-0.006582214031368494,
-0.02735527604818344,
-0.033418312668800354,
0.008157649077475071,
-0.012591542676091194,
-0.008199421688914299,
0.016542064025998116,
-0.042990271002054214,
0.015766281634569168,
0.015133720822632313,
-0.01787879690527916,
-0.0029524480924010277,
-0.041104525327682495,
0.004278737585991621,
-0.019012631848454475,
0.0004322748281992972,
-0.00699397549033165,
-0.018523292616009712,
-0.004150434862822294,
0.039743922650814056,
-0.023070570081472397,
0.018523292616009712,
-0.02718818373978138,
-0.007107358891516924,
-0.008927463553845882,
-0.004159386269748211,
0.006946234963834286,
-0.007161066867411137,
-0.0044577643275260925,
0.006779143121093512,
0.00018070504302158952,
-0.003875927533954382,
-0.0013195757055655122,
0.01604078896343708,
-0.03172352537512779,
0.0035447280388325453,
-0.007131229154765606,
-0.037476249039173126,
-0.011970916762948036,
0.020385170355439186,
-0.018964892253279686,
0.004687515087425709,
-0.009995656087994576,
0.02513534389436245,
-0.03816848620772362,
0.014871148392558098,
-0.019227463752031326,
0.020277753472328186,
0.048838477581739426,
-0.08846304565668106,
-0.022891543805599213,
0.009768888354301453,
0.008999073877930641,
-0.02192479930818081,
-0.017866861075162888,
-0.008121843449771404,
0.012317035347223282,
0.021172886714339256,
-0.027259794995188713,
0.023679260164499283,
-0.019967440515756607,
0.0119649488478899,
0.018797799944877625,
0.0091243926435709,
-0.026257244870066643,
-0.024001508951187134,
-0.05709757283329964,
0.0026048379950225353,
0.01892908662557602,
0.006880591623485088,
-0.013379259966313839,
-0.026257244870066643,
0.02866813726723194,
0.0007727984921075404,
0.011756084859371185,
-0.018702318891882896,
-0.019227463752031326,
-0.05280093103647232,
0.005251449067145586,
0.023834416642785072,
0.01897682622075081,
-0.039147164672613144,
0.015849828720092773,
0.01125480979681015,
-0.02045678161084652,
0.033155739307403564,
-0.022855738177895546,
-0.013427000492811203,
0.025851450860500336,
-0.00031441557803191245,
0.023368949070572853,
0.03511309623718262,
-0.008103940635919571,
-0.036998845636844635,
-0.015646930783987045,
-0.00888569001108408,
-0.003908749204128981,
0.0008966252207756042,
-0.010079201310873032,
0.02766558900475502,
0.004923233296722174,
-0.018272655084729195,
-0.009184068068861961,
0.0124602559953928,
0.012096235528588295,
-0.00561248604208231,
0.023738937452435493,
0.029861649498343468,
0.013570222072303295,
-0.013725378550589085,
0.07285191863775253,
0.055092472583055496,
-0.006397219840437174,
-0.001846958533860743,
-0.02298702485859394,
-0.021948669105768204,
0.02814299240708351,
-0.04855203256011009,
0.022998958826065063,
-0.02714044414460659,
0.012484126724302769,
-0.02323766238987446,
0.009792759083211422,
-0.007011877838522196,
-0.0009160197805613279,
-0.0048128338530659676,
-0.008503766730427742,
0.03458795323967934,
-0.00035786686930805445,
0.00896923616528511,
-0.01608853042125702,
-0.03045840375125408,
-0.015217266976833344,
-0.027522366493940353,
-0.007232677657157183,
-0.013367325067520142,
0.03761947154998779,
0.050031986087560654,
-0.008909560739994049,
0.009112457744777203,
-0.0226170364767313,
-0.015241137705743313,
-0.00247951946221292,
-0.016291426494717598,
-0.005111211445182562,
-0.013510545715689659,
0.03150869533419609,
0.009267614223062992,
-0.020683547481894493,
0.044303134083747864,
-0.00016494696319568902,
0.0028793455567210913,
-0.040197454392910004,
-0.04182063043117523,
0.015276942402124405,
0.031365472823381424,
-0.01577821746468544,
0.014298263005912304,
-0.010461125522851944,
0.041414838284254074,
-0.008473929017782211,
0.009709212929010391,
0.03406280651688576,
-0.01161883119493723,
0.026281114667654037,
0.04824171960353851,
0.0028569672722369432,
-0.003911732695996761,
0.010097104124724865,
0.032535113394260406,
0.032057709991931915,
0.008491831831634045,
-0.012448321096599102,
-0.028095252811908722,
0.01908424310386181,
0.006701564881950617,
0.02749849669635296,
0.005621437449008226,
-0.014763732440769672,
0.011207069270312786,
-0.014035690575838089,
0.01919165998697281,
-0.031150640919804573,
-0.009142295457422733,
0.04432700201869011,
0.013319584541022778,
0.0482894591987133,
-0.005063470918685198,
0.03766721114516258,
0.0027271730359643698,
0.0018409909680485725,
-0.009589862078428268,
-0.003049420891329646,
0.030888067558407784,
0.0035268254578113556,
-0.03060162626206875,
0.009428737685084343,
0.0022184387780725956,
0.015814023092389107,
-0.0003942316398024559,
0.03812074661254883,
0.019740674644708633,
0.06588181853294373,
0.0027913241647183895,
0.019895831122994423,
0.008629085496068,
-0.048146240413188934,
0.012143976055085659,
-0.0007056634640321136,
-0.048623643815517426,
0.029861649498343468,
-0.040889691561460495,
-0.0029196266550570726,
-0.017962342128157616,
-0.00927954912185669,
-0.004574131220579147,
-0.010962399654090405,
0.027259794995188713,
0.00838441587984562,
-0.012961531057953835,
-0.03375249356031418,
0.009434705600142479,
-0.01778331585228443,
-0.008826014585793018,
0.040364548563957214,
0.03255898505449295,
0.012770568951964378,
0.004126564599573612,
0.01069982722401619,
-0.005227578803896904,
0.0012994352728128433,
-0.006158517673611641,
0.027331404387950897,
0.027570107951760292,
0.0036521439906209707,
0.014704057015478611,
-0.0056900642812252045,
0.014298263005912304,
0.009577927179634571,
-0.03422990068793297,
-0.018654579296708107,
0.002361660124734044,
0.021017732098698616,
0.003810284426435828,
-0.02166222780942917,
-0.011845597997307777,
0.020600002259016037,
-0.031174510717391968,
-0.02387022227048874,
-0.0856463611125946,
0.011899306438863277,
0.03439699113368988,
-0.01766396500170231,
-0.01069982722401619,
0.0077339522540569305,
0.02297508902847767,
-0.0253501757979393,
-0.025469528511166573,
0.03112677112221718,
0.0004900855128653347,
0.04879073426127434,
-0.0014806997496634722,
0.03754786029458046,
-0.0010376087157055736,
0.017126884311437607,
0.03680788353085518,
-0.010550638660788536,
-0.02597080171108246,
-0.02461019903421402,
-0.03661692142486572,
-0.038096874952316284,
-0.013916339725255966,
-0.03055388480424881,
-0.017532678321003914,
0.02182931825518608,
0.01212010532617569,
0.007453477010130882,
0.01798621378839016,
-0.009906142018735409,
-0.03377636522054672,
-0.00983453169465065,
0.02067161351442337,
0.004511472303420305,
0.019860025495290756,
-0.009792759083211422,
0.013653767295181751,
-0.005552810616791248,
0.013259909115731716,
0.0015948292566463351,
0.0292887631803751,
0.03716593608260155,
0.022998958826065063,
-0.035638242959976196,
0.004353331867605448,
0.0034701337572187185,
0.03033905290067196,
-0.026257244870066643,
-0.0005699015455320477,
0.014059561304748058,
-0.04955458268523216,
0.007196872029453516,
0.03356153145432472,
0.04776431620121002,
0.03454021364450455,
0.003174739656969905,
0.003816251875832677,
-0.004263818729668856,
0.02150707133114338,
0.0183562021702528,
-0.015599190257489681,
-0.014871148392558098,
0.04012584313750267,
-0.03129386156797409,
0.021542876958847046,
-0.014906954020261765,
-0.01359409186989069,
0.007775724865496159,
0.02372700162231922,
-0.0031359505373984575,
0.0017947424203157425,
0.02924102358520031,
0.006629954557865858,
0.00967937521636486,
-0.004517439752817154,
0.008092005737125874,
-0.0033179610036313534,
-0.017998147755861282,
-0.03055388480424881,
-0.01291379053145647,
-0.0148592134937644,
0.011732214130461216,
-0.013403129763901234,
0.017998147755861282,
0.016947858035564423,
-0.010437254793941975,
-0.0038192356005311012,
0.007447509560734034,
0.01130851823836565,
-0.024013444781303406,
-0.00967937521636486,
0.022414138540625572,
-0.028859099373221397,
-0.024216340854763985,
-0.04595017805695534,
-0.023965703323483467,
0.0069760726764798164,
0.0036073874216526747,
-0.00791894644498825,
-0.005424508359283209,
0.025588879361748695,
0.008479896932840347,
-0.014322133734822273,
-0.004603969398885965,
0.005260400474071503,
-0.010789340361952782,
-0.011230939999222755,
-0.042369645088911057,
0.06712306290864944,
0.0005505069857463241,
-0.026734650135040283,
0.021602552384138107,
0.04685724899172783,
-0.031675785779953,
0.0417490191757679,
0.008038297295570374,
-0.00019916717428714037,
0.02692561224102974,
0.0022169470321387053,
0.03246350213885307,
-0.023416688665747643,
0.020683547481894493,
-0.005812399089336395,
-0.027522366493940353,
-0.013176362961530685,
0.010186617262661457,
0.00529918959364295,
0.005839253310114145,
-0.027522366493940353,
-0.005487167276442051,
0.03592468425631523,
-0.017377521842718124,
0.013773118145763874,
-0.0034343283623456955,
0.027546236291527748,
0.006683662533760071,
0.03687949478626251,
-0.0022661793045699596,
0.02402537874877453,
0.006582214031368494,
-0.01556338556110859,
0.0026913676410913467,
-0.006301738787442446,
0.009935980662703514,
0.01715075597167015,
-0.011821728199720383,
-0.004967990331351757,
-0.017652029171586037,
-0.019263269379734993,
-0.023022830486297607,
0.05475829169154167,
-0.03169965744018555,
-0.0364975705742836,
0.033107999712228775,
0.01676883175969124,
-0.023321207612752914,
0.005511037539690733,
-0.018260721117258072,
0.007268482819199562,
-0.003389571560546756,
0.004517439752817154,
0.029742296785116196,
0.009530186653137207,
-0.014429549686610699,
0.02145932987332344,
-0.0015963211189955473,
-0.023595714941620827,
-0.028166862204670906,
-0.013916339725255966,
0.007799595128744841,
0.018893280997872353,
-0.00954808946698904,
-0.029861649498343468,
-0.014011820778250694,
0.01703140325844288,
0.013033141382038593,
0.03549502044916153,
0.010335806757211685,
-0.004550261422991753,
0.03895620256662369,
0.022760257124900818,
-0.011797857470810413,
-0.004815817344933748,
0.0025153246242552996,
0.0016142238164320588,
-0.010622248984873295,
-0.015026304870843887,
-0.04117613285779953,
-0.019895831122994423,
0.017699770629405975,
-0.007155099418014288,
-0.03155643492937088,
0.011768019758164883,
-0.0157304760068655,
-0.010735632851719856,
-0.00434139696881175,
-0.011893338523805141,
0.005373783875256777,
-0.015599190257489681,
-0.007202839944511652,
-0.03561437129974365,
-0.021160952746868134,
0.01962132379412651,
-0.00005920934199821204,
-0.008217324502766132,
0.01877393014729023,
-0.004114629700779915,
-0.005349913612008095,
0.01636303775012493,
0.025541137903928757,
-0.04210707172751427,
0.00804426521062851,
-0.05599954351782799,
0.016291426494717598,
-0.023392818868160248,
0.006970105227082968,
0.004251883365213871,
-0.01556338556110859,
-0.017449133098125458,
0.007626536302268505,
-0.004219061695039272,
0.010300001129508018,
0.006343511864542961,
-0.014966629445552826,
0.0032045773696154356,
-0.006922364700585604,
0.008861820213496685,
-0.0002795426989905536,
-0.04912491887807846,
0.007590730674564838,
-0.02788042090833187,
-0.002457141177728772,
0.01306894700974226,
-0.027689458802342415,
-0.04487602040171623,
0.005937717854976654,
-0.004791947081685066,
0.027283664792776108,
-0.0030180911999195814,
-0.003992294892668724,
0.014704057015478611,
-0.006767208222299814,
0.044995371252298355,
0.017365587875247,
-0.00492920121178031,
-0.025278566405177116,
-0.018332330510020256,
0.000641512218862772,
-0.01619594544172287,
0.019537776708602905,
0.0330125167965889,
0.019657129421830177,
-0.030100351199507713,
-0.016398843377828598,
-0.011583025567233562,
-0.021996410563588142,
-0.01604078896343708,
-0.03656918182969093,
0.00007879038457758725,
0.012770568951964378,
-0.022628970444202423,
-0.002771929604932666,
0.009565991349518299,
0.030959678813815117,
0.010156779550015926,
-0.012006722390651703,
-0.004675579722970724,
-0.023166051134467125,
-0.0028838212601840496,
-0.02382248267531395,
0.0020155420061200857,
0.006098841782659292,
0.02513534389436245,
-0.008903592824935913,
0.01897682622075081,
-0.02692561224102974,
0.03981553018093109,
0.005842237267643213,
0.013236038386821747,
-0.014954694546759129,
-0.03375249356031418,
0.029622945934534073,
-0.010055331513285637,
0.003431344637647271,
-0.002968858927488327,
0.041939981281757355,
-0.02854878641664982,
-0.03313186764717102,
0.046618543565273285,
0.005003795493394136,
0.00922584068030119,
-0.0192393995821476,
-0.02718818373978138,
0.023273468017578125,
0.00027003188733942807,
0.006683662533760071,
0.01380892377346754,
-0.007692179176956415,
-0.007572828326374292,
0.007131229154765606,
0.0018409909680485725,
-0.009082620032131672,
-0.008820047602057457,
0.0009622683865018189,
0.018212979659438133,
-0.017067208886146545,
-0.04201159253716469,
-0.06354252994060516,
0.017103014513850212,
-0.00807410292327404,
-0.02823847346007824,
-0.027021091431379318,
-0.011010140180587769,
-0.0029032158199697733,
0.022151567041873932,
-0.062349021434783936,
-0.007668308913707733,
0.017389457672834396,
0.005988442339003086,
0.015587255358695984,
0.026424337178468704,
0.014847278594970703,
-0.0040967268869280815,
0.020850639790296555,
0.008479896932840347,
-0.0032642530277371407,
0.01109965331852436,
0.021650291979312897,
-0.024801161140203476,
0.020265819504857063,
-0.0013456838205456734,
0.016637545078992844,
0.0005475232610478997,
-0.021733837202191353,
-0.016064660623669624,
0.045568253844976425,
-0.028119122609496117,
-0.02334507741034031,
-0.0012860082788392901,
0.0019290123600512743,
-0.032057709991931915,
0.004806865938007832,
0.013606026768684387,
-0.0036044036969542503,
0.03267833590507507,
0.0017798234475776553,
0.04122387617826462,
-0.00933325756341219,
-0.010956432670354843,
0.017687834799289703,
0.03637821972370148,
0.0033657015301287174,
0.0016336183762177825,
-0.011272712610661983,
-0.024443108588457108,
-0.01882167160511017,
-0.0182487852871418,
0.006373349577188492,
-0.0025973785668611526,
0.0031359505373984575,
0.0010957923950627446,
-0.009142295457422733,
-0.007184937130659819,
0.0158378928899765,
-0.011063848622143269,
0.005269351880997419,
0.0021960604935884476,
0.0021930767688900232,
-0.03785817325115204,
-0.021948669105768204,
-0.011063848622143269,
-0.0038341544568538666,
-0.008951333351433277,
0.009398899972438812,
-0.034373119473457336,
-0.0018096612766385078,
-0.0002679805620573461,
-0.025111474096775055,
0.021065471693873405,
0.00833070743829012,
0.0033179610036313534,
0.028787488117814064,
-0.005973523482680321,
0.0225096195936203,
-0.029622945934534073,
0.004281721077859402,
-0.009941947646439075,
0.023476364091038704,
-0.013689572922885418,
-0.00783540029078722,
-0.06626373529434204,
0.01792653650045395,
0.01666141487658024,
-0.023834416642785072,
0.04812236875295639,
0.015754347667098045,
-0.01703140325844288,
0.00671946769580245,
-0.024538589641451836,
-0.0016380940796807408,
0.016100464388728142,
0.006158517673611641,
-0.004511472303420305,
-0.017950408160686493,
-0.036258868873119354,
-0.0070178452879190445,
-0.016482388600707054,
-0.02914554253220558,
-0.013128622435033321,
-0.006820916198194027,
-0.011129491031169891,
0.00539168668910861,
0.007477347273379564,
0.000332691241055727,
-0.03112677112221718,
0.028429435566067696,
-0.02718818373978138,
-0.00893939845263958,
-0.01704333908855915,
-0.008957301266491413,
0.033060260117053986,
0.021268367767333984,
-0.01735365204513073,
0.019215529784560204,
0.031317733228206635,
0.0025705245789140463,
0.017341716215014458,
-0.019167788326740265,
0.02298702485859394,
-0.013045077212154865,
-0.02141159027814865,
0.028954580426216125,
0.0053827352821826935,
-0.03991101309657097,
-0.0038669761270284653,
-0.01335538923740387,
-0.03098354861140251,
0.034683432430028915,
-0.02566048875451088,
0.014966629445552826,
0.008068135008215904,
0.022593166679143906,
0.023428624495863914,
0.008694728836417198,
-0.015085981227457523,
0.022378334775567055,
-0.002452665474265814,
-0.017449133098125458,
-0.0019006665097549558,
-0.01062821689993143,
-0.021339979022741318,
0.015611126087605953,
0.011207069270312786,
-0.0020811851136386395,
0.023106375709176064,
-0.005502086132764816,
-0.011147393845021725,
0.025755969807505608,
-0.002828621305525303,
0.005039600655436516,
0.015790153294801712,
-0.02451471798121929,
-0.010234357789158821,
0.0054483781568706036,
-0.0015269482973963022,
0.002099087694659829,
0.0371420681476593,
0.03676014393568039,
-0.013319584541022778,
-0.0014926348812878132,
-0.011523350141942501,
-0.007716049440205097,
-0.003938586916774511,
-0.003070307429879904,
0.1529603898525238,
-0.03243963420391083,
-0.013116687536239624,
0.004794931039214134,
-0.02482503093779087,
-0.05805238336324692,
0.03812074661254883,
0.0038669761270284653,
0.04074646905064583,
-0.0206596776843071,
0.0018976826686412096,
0.0037177870981395245,
0.021328043192625046,
0.031460952013731,
0.02513534389436245,
0.01320023275911808,
0.007698147092014551,
0.00687462417408824,
-0.00005967555625829846,
-0.0057825613766908646,
-0.024634070694446564,
-0.008097972720861435,
0.012412515468895435,
0.019537776708602905,
-0.025278566405177116,
-0.021745773032307625,
-0.0038222193252295256,
-0.020098727196455002,
-0.014226652681827545,
-0.013904404826462269,
0.023213792592287064,
0.020230013877153397,
0.03592468425631523,
-0.012084300629794598,
0.002478027483448386,
-0.035996295511722565,
-0.021268367767333984,
-0.025111474096775055,
0.012000754475593567,
-0.021423524245619774,
-0.008509734645485878,
0.021387720480561256,
0.004436877556145191,
-0.0069760726764798164,
0.0249205119907856,
0.027952030301094055,
-0.005949653219431639,
0.025684360414743423,
0.010473060421645641,
-0.005681112874299288,
0.012048495002090931,
0.018964892253279686,
0.013140557333827019,
0.01588563248515129,
-0.02513534389436245,
0.0053797513246536255,
0.03866976127028465,
-0.012317035347223282,
0.007542990613728762,
0.002521292306482792,
-0.018380071967840195,
0.014166977256536484,
0.008849885314702988,
0.00616448512300849,
0.011403999291360378
] | 2024-06-29 | 1 | 38943466 | [
"CAR T cells",
"CAR T cell function",
"future CAR T cell generations",
"advanced switch systems",
"the CAR T cell field",
"selected hematologic malignancies",
"new avenues",
"great excitement",
"small molecule-regulated switch systems",
"these engineered immune cells",
"their remarkable clinical response rates",
"drugs",
"those switch systems",
"administration",
"an urgent need",
"the most important obstacles",
"the patient",
"We",
"they",
"we",
"which"
] | [
"CAR T cells",
"ON-switch",
"chemically induced dimerization (CID)",
"chimeric antigen receptor (CAR)",
"heterodimerization",
"molecular switch",
"small molecule drug",
"split CAR"
] | 0 | 10.1080/14712598.2024.2371034 | [
"Zajc",
"Sylvander",
"Lehner",
"Traxlmayr"
] | [
"Department of Chemistry, Institute of Biochemistry, BOKU University, Vienna, Austria.\nCD Laboratory for Next Generation CAR T Cells, Vienna, Austria.",
"CD Laboratory for Next Generation CAR T Cells, Vienna, Austria.\nSt. Anna Children´s Cancer Research Institute, CCRI, Vienna, Austria.",
"CD Laboratory for Next Generation CAR T Cells, Vienna, Austria.\nSt. Anna Children´s Cancer Research Institute, CCRI, Vienna, Austria.\nDepartment of Pediatrics, St. Anna Kinderspital, Medical University of Vienna, Vienna, Austria.",
"Department of Chemistry, Institute of Biochemistry, BOKU University, Vienna, Austria.\nCD Laboratory for Next Generation CAR T Cells, Vienna, Austria."
] | [
"38943466"
] | [] | 8.870276 | 3.725671 |
38943167 | 793 | Steering the course of CAR T cell therapy with lipid nanoparticles. | Lipid nanoparticles (LNPs) have proven themselves as transformative actors in chimeric antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing challenges like immunogenicity, reduced toxicity, and improved safety. Promising preclinical results signal a shift toward safer and more effective CAR T cell treatments. Ongoing research aims to validate these findings in clinical trials, marking a new era guided by LNPs utility in CAR therapy. Herein, we explore the preference for LNPs over traditional methods, highlighting the versatility of LNPs and their effective delivery of nucleic acids. Additionally, we address key challenges in clinical considerations, heralding a new era in CAR T cell therapy. | [
0.006769852712750435,
-0.028514888137578964,
0.04299130290746689,
0.048197947442531586,
-0.013989812694489956,
-0.03637351468205452,
-0.015486114658415318,
-0.006246755365282297,
0.015230648219585419,
0.007724809926003218,
-0.021434826776385307,
0.0034852882381528616,
-0.06413416564464569,
-0.010997209697961807,
-0.00328152347356081,
-0.03403782472014427,
0.025449294596910477,
-0.02215256541967392,
0.024147633463144302,
0.009263688698410988,
0.020412961021065712,
0.008789251558482647,
-0.001899269176647067,
-0.017310872673988342,
-0.004072252195328474,
-0.039633747190237045,
0.04206676036119461,
0.006538717076182365,
-0.011410821229219437,
-0.023356905207037926,
0.020485952496528625,
-0.02634950913488865,
-0.017383862286806107,
0.011502059176564217,
0.007797800004482269,
0.048027634620666504,
0.04024200141429901,
-0.006319745909422636,
-0.013527540490031242,
-0.023709692060947418,
0.010741743259131908,
0.03126418963074684,
0.01228670496493578,
0.04968208447098732,
-0.04484039172530174,
0.013211249373853207,
-0.020437292754650116,
-0.03496236726641655,
0.007487591356039047,
0.021994419395923615,
-0.03924446552991867,
0.02223771996796131,
-0.01682427152991295,
0.038538891822099686,
-0.08165184408426285,
0.04649483785033226,
-0.019208621233701706,
0.015048172324895859,
-0.018198922276496887,
0.013637026771903038,
-0.001727437716908753,
-0.029731392860412598,
0.026008887216448784,
0.015984881669282913,
-0.06632387638092041,
-0.0008333062287420034,
-0.08432815968990326,
-0.0024953568354249,
-0.029877373948693275,
0.0662752166390419,
0.039682406932115555,
-0.045691944658756256,
-0.035302989184856415,
0.01367352157831192,
0.01510899793356657,
0.01456157024949789,
0.007323362864553928,
0.0469571128487587,
0.018357068300247192,
-0.0219214279204607,
0.01367352157831192,
-0.009762456640601158,
0.005069786682724953,
-0.0657886192202568,
-0.011885258369147778,
-0.014366929419338703,
0.029098810628056526,
-0.012505676597356796,
-0.06466943025588989,
-0.007676149718463421,
-0.00503633264452219,
-0.024877537041902542,
-0.04685978963971138,
0.04179912805557251,
-0.015413124114274979,
0.04895218089222908,
-0.02885551005601883,
-0.005422573070973158,
0.05245571583509445,
0.05041198804974556,
0.06067929416894913,
0.009409669786691666,
-0.0266171395778656,
0.0023782681673765182,
0.05104456841945648,
0.018576039001345634,
-0.015267143957316875,
-0.01878284476697445,
0.04138551652431488,
-0.018624698743224144,
0.03686011582612991,
-0.00042387613211758435,
-0.014890027232468128,
0.053574901074171066,
-0.008077596314251423,
-0.048246607184410095,
0.008460795506834984,
0.012590832076966763,
0.011800102889537811,
0.041507165879011154,
-0.030461296439170837,
0.044378120452165604,
0.047881655395030975,
-0.03552195802330971,
-0.0020422085653990507,
-0.06661584228277206,
0.0657399520277977,
-0.035084016621112823,
0.01672695018351078,
-0.06476674973964691,
-0.014342599548399448,
0.0074571785517036915,
0.03841724246740341,
-0.03883085399866104,
-0.07678582519292831,
0.01991419494152069,
-0.013758677057921886,
-0.019573573023080826,
-0.01936676725745201,
0.003284564707428217,
0.047881655395030975,
-0.04622720927000046,
0.012183302082121372,
-0.005267468746751547,
-0.018077271059155464,
-0.003953642677515745,
-0.011301335878670216,
0.03873353451490402,
0.002054373500868678,
0.05284499749541283,
-0.030290985479950905,
0.03683578595519066,
0.03722506761550903,
0.02895282953977585,
-0.030874907970428467,
-0.040047358721494675,
-0.003999261651188135,
0.05245571583509445,
0.005574636161327362,
-0.040777262300252914,
-0.026860440149903297,
0.03914714604616165,
-0.02460990473628044,
-0.0328943096101284,
0.033478230237960815,
0.014731881208717823,
-0.0003702738613355905,
-0.019537078216671944,
-0.05342892184853554,
0.008643271401524544,
-0.01846655271947384,
-0.04123953729867935,
-0.06934081017971039,
-0.02279731258749962,
-0.03021799586713314,
-0.03437844291329384,
0.01795561984181404,
0.020035844296216965,
-0.017262212932109833,
0.006404901389032602,
0.009464412927627563,
0.011137107387185097,
0.00632582837715745,
-0.05192045494914055,
-0.02124018594622612,
0.02175111696124077,
-0.013442385010421276,
0.021215856075286865,
-0.046154215931892395,
-0.04530266299843788,
-0.006003454327583313,
0.027468694373965263,
0.05751637741923332,
0.036130212247371674,
0.013284239917993546,
0.003284564707428217,
0.031239859759807587,
0.03554629161953926,
0.010565349832177162,
-0.030072014778852463,
0.029877373948693275,
-0.012244127690792084,
-0.017651494592428207,
-0.00015843083383515477,
-0.017992116510868073,
-0.01492652203887701,
-0.03294296935200691,
0.015838900581002235,
0.01278547290712595,
-0.026860440149903297,
0.04768701270222664,
0.026738790795207024,
0.019074805080890656,
0.0000942791739362292,
-0.03330792114138603,
-0.012365777976810932,
-0.04048530384898186,
0.06282034516334534,
0.002054373500868678,
-0.003500494407489896,
-0.005124529357999563,
-0.015972716733813286,
0.01951274834573269,
0.0318237841129303,
-0.038587555289268494,
-0.027249721810221672,
0.014610230922698975,
-0.06199311837553978,
0.009853694587945938,
-0.024536915123462677,
-0.004449368920177221,
0.014987347647547722,
0.004750453867018223,
-0.02515733242034912,
-0.03510834649205208,
-0.01636199839413166,
0.030607277527451515,
-0.004966383799910545,
0.03214007616043091,
0.011155354790389538,
0.019524913281202316,
0.00452540023252368,
0.031020889058709145,
-0.013989812694489956,
-0.01599704660475254,
-0.016897261142730713,
-0.03797930106520653,
-0.034986697137355804,
0.040266331285238266,
-0.009452247060835361,
-0.016033541411161423,
0.00022201225510798395,
0.008965644985437393,
-0.024232789874076843,
0.021811943501234055,
0.00970771349966526,
0.028003955259919167,
-0.03668980672955513,
0.007554498966783285,
-0.009044717997312546,
0.026130536571145058,
-0.012663821689784527,
-0.002594197867438197,
-0.007317280396819115,
-0.03788198158144951,
-0.010468029417097569,
-0.00854595098644495,
0.057954318821430206,
0.016520144417881966,
-0.0029196131508797407,
0.048757538199424744,
-0.02990170381963253,
0.018989650532603264,
-0.05810030177235603,
-0.02880685031414032,
-0.004823444411158562,
-0.018247582018375397,
0.0381009504199028,
-0.005042415112257004,
0.06491272896528244,
-0.015327968634665012,
-0.0072747026570141315,
0.0019266405142843723,
-0.027274053543806076,
-0.027614673599600792,
-0.03228605538606644,
-0.003126419149339199,
-0.01581457071006298,
0.007639654446393251,
-0.0673457458615303,
0.024354439228773117,
-0.013320734724402428,
-0.024366604164242744,
0.00045048719039186835,
0.002274865284562111,
0.005662832874804735,
-0.04656783118844032,
-0.008424300700426102,
-0.0170919019728899,
0.017383862286806107,
-0.032845646142959595,
-0.0007139366352930665,
0.00669078016653657,
-0.06539933383464813,
0.021580807864665985,
0.03179945424199104,
0.0012332324404269457,
-0.019026145339012146,
-0.01608220301568508,
0.039536427706480026,
0.02812560647726059,
-0.00641706632450223,
0.013576201163232327,
-0.017578503116965294,
0.0033362661488354206,
0.027225391939282417,
0.0031872442923486233,
-0.04754103347659111,
-0.022140400484204292,
-0.01599704660475254,
-0.009768539108335972,
-0.0019266405142843723,
0.01941542699933052,
-0.017286542803049088,
0.015400959178805351,
-0.0180042814463377,
0.031215529888868332,
-0.018855834379792213,
0.023673197254538536,
-0.01474404614418745,
0.001981383189558983,
-0.047103092074394226,
0.03537597879767418,
-0.011988661251962185,
-0.010017922148108482,
-0.0075666639022529125,
-0.004954218398779631,
-0.06530201435089111,
0.05883020535111427,
0.03294296935200691,
-0.014476414769887924,
0.03296729922294617,
-0.007061814423650503,
0.060095369815826416,
0.02958541363477707,
-0.0014620875008404255,
0.011362161487340927,
0.015376629307866096,
-0.004330759402364492,
0.05547264963388443,
-0.028563547879457474,
0.008527703583240509,
0.014719716273248196,
0.0004911641008220613,
0.0040631284937262535,
0.05265035852789879,
-0.008047183975577354,
-0.060241349041461945,
0.009373174980282784,
-0.00314466655254364,
0.007305115461349487,
-0.02316226437687874,
-0.05600791051983833,
0.05265035852789879,
-0.017602834850549698,
0.03982838988304138,
-0.014074968174099922,
0.016021376475691795,
-0.05566728860139847,
-0.028563547879457474,
0.04520534351468086,
0.006532634142786264,
0.012165054678916931,
0.029342111200094223,
-0.026227857917547226,
0.05240705609321594,
0.03204275295138359,
-0.0009663615492172539,
0.012092064134776592,
-0.03167780116200447,
0.008813582360744476,
-0.003254152135923505,
0.007390270940959454,
0.0040631284937262535,
-0.018150262534618378,
0.034986697137355804,
0.019488418474793434,
-0.03179945424199104,
-0.051579833030700684,
0.01571725122630596,
-0.00568412197753787,
-0.029366442933678627,
0.029098810628056526,
-0.01823541708290577,
-0.010322049260139465,
0.04586225748062134,
-0.007846460677683353,
0.07362291216850281,
0.05172581225633621,
-0.01682427152991295,
-0.007268620189279318,
0.004209109116345644,
-0.03214007616043091,
-0.032334715127944946,
0.030242325738072395,
-0.008965644985437393,
0.049025170505046844,
0.023819176480174065,
0.01631333865225315,
-0.002691518282517791,
-0.0022657413501292467,
0.01401414256542921,
0.03194543346762657,
-0.021313175559043884,
0.06900019198656082,
0.009543485008180141,
0.009427917189896107,
0.032748326659202576,
-0.021276680752635002,
0.04914681985974312,
0.04325893521308899,
-0.011392573826014996,
-0.006283250637352467,
-0.04043664038181305,
0.022505350410938263,
0.011204015463590622,
0.02351505123078823,
-0.01895315572619438,
-0.022627001628279686,
-0.07372023165225983,
-0.01276114210486412,
0.05775967985391617,
0.016337668523192406,
-0.026130536571145058,
0.003990137949585915,
-0.0019616151694208384,
-0.04941445216536522,
0.03846590220928192,
-0.017627164721488953,
0.020546777173876762,
-0.00041323169716633856,
-0.0007899682386778295,
-0.018223252147436142,
-0.001118424697779119,
0.008521621115505695,
-0.024634236469864845,
-0.02256617695093155,
0.010096995159983635,
-0.031118210405111313,
-0.028466228395700455,
-0.011842681095004082,
-0.0005162545130588114,
0.04705443233251572,
-0.0004858418833464384,
-0.030558617785573006,
-0.014622395858168602,
0.029050150886178017,
-0.07834295183420181,
0.036300525069236755,
0.00788903795182705,
0.05055796727538109,
-0.01845438778400421,
0.0412152037024498,
0.0025820329319685698,
0.026495488360524178,
0.04603256657719612,
0.009354926645755768,
-0.04571627452969551,
0.03250502794981003,
-0.011009374633431435,
0.025497954338788986,
-0.027371373027563095,
-0.026081876829266548,
0.01167237013578415,
-0.057370398193597794,
0.05065528675913811,
0.012000826187431812,
0.005982165690511465,
0.020449457690119743,
0.01951274834573269,
-0.0067576877772808075,
0.011648040264844894,
-0.006514386739581823,
-0.018563874065876007,
0.022639166563749313,
0.034719064831733704,
0.023454224690794945,
0.03474339470267296,
-0.04841691628098488,
-0.001509227091446519,
0.01895315572619438,
-0.003962766379117966,
0.011471646837890148,
-0.011666287668049335,
-0.0255709458142519,
-0.027614673599600792,
-0.02880685031414032,
-0.006727275438606739,
-0.009111626073718071,
0.020753582939505577,
0.015486114658415318,
0.009135955944657326,
-0.002560744062066078,
0.024682896211743355,
0.0647180899977684,
0.05810030177235603,
0.013004443608224392,
0.050168685615062714,
-0.023235253989696503,
0.03413514420390129,
-0.024731555953621864,
-0.010048335418105125,
0.023466389626264572,
-0.03179945424199104,
-0.02958541363477707,
-0.011045869439840317,
-0.03308894857764244,
-0.016945920884609222,
-0.026422498747706413,
-0.0006272606551647186,
0.015705086290836334,
0.03678712621331215,
0.018661193549633026,
0.011343913152813911,
0.009032553061842918,
-0.016872931271791458,
-0.03751702979207039,
-0.0511418916285038,
-0.02006017602980137,
-0.04445111006498337,
0.029463762417435646,
-0.022845972329378128,
-0.009482660330832005,
0.013174754567444324,
-0.03223739564418793,
-0.0015130286337807775,
-0.01851521246135235,
0.008631106466054916,
-0.01978037878870964,
-0.03620320186018944,
0.01426960900425911,
0.009148120880126953,
0.015023842453956604,
-0.025327643379569054,
0.006350158713757992,
-0.002776673762127757,
0.020485952496528625,
-0.06875688582658768,
0.01187309343367815,
0.0043946257792413235,
0.023369070142507553,
-0.024147633463144302,
-0.0006557724555023015,
-0.007146969437599182,
0.008947397582232952,
-0.017262212932109833,
-0.017675824463367462,
-0.02255401201546192,
0.003433586796745658,
-0.009008223190903664,
-0.018855834379792213,
-0.0028238133527338505,
0.011313500814139843,
-0.022189060226082802,
-0.02429361455142498,
0.005909175146371126,
0.009099461138248444,
0.0006945485947653651,
-0.05605657026171684,
0.0157780759036541,
-0.041507165879011154,
-0.002787318080663681,
0.012566501274704933,
-0.03722506761550903,
0.05026600509881973,
-0.005203602369874716,
-0.01704324223101139,
-0.0006850446225143969,
-0.02027914673089981,
0.02707941085100174,
-0.016970250755548477,
-0.0281742662191391,
-0.018198922276496887,
0.03372153267264366,
-0.011611544527113438,
0.024378769099712372,
-0.04685978963971138,
0.003984055481851101,
0.0033362661488354206,
0.04274800047278404,
0.009561733342707157,
-0.017104066908359528,
0.01950058341026306,
0.023734021931886673,
-0.04858722910284996,
-0.008357392624020576,
0.037444040179252625,
-0.03936611860990524,
-0.040314991027116776,
-0.009281937032938004,
-0.02917180210351944,
0.022760817781090736,
-0.0032115743961185217,
-0.03089923970401287,
-0.02707941085100174,
0.0036829703021794558,
-0.023137934505939484,
-0.02547362446784973,
0.0011199453147128224,
-0.013454550877213478,
0.02402598224580288,
0.0006234590546227992,
0.020838739350438118,
0.004081375896930695,
0.005559429991990328,
0.0029059273656457663,
0.016848601400852203,
0.0047565363347530365,
0.0008439506636932492,
-0.06398818641901016,
-0.030972229316830635,
0.010024004615843296,
-0.030801918357610703,
0.024804547429084778,
-0.02479238063097,
-0.025814246386289597,
-0.014050638303160667,
-0.0012233483139425516,
-0.023636700585484505,
0.01878284476697445,
-0.005434738006442785,
-0.03673846647143364,
0.001967697637155652,
0.040047358721494675,
-0.011021539568901062,
-0.035765260457992554,
0.0073659406043589115,
-0.029098810628056526,
-0.027371373027563095,
0.002962190890684724,
-0.008716261945664883,
0.01257866621017456,
0.0059030926786363125,
-0.024634236469864845,
0.009239358827471733,
0.0037924558855593204,
-0.026495488360524178,
-0.01759066991508007,
0.033478230237960815,
-0.014549405314028263,
-0.00018608731625135988,
-0.033064618706703186,
0.027784984558820724,
-0.0126516567543149,
-0.013624860905110836,
-0.020084505900740623,
0.028636539354920387,
0.0005881043616682291,
0.046519167721271515,
0.07960812002420425,
-0.03240770474076271,
0.007615324109792709,
-0.0028435816057026386,
0.0031477080192416906,
-0.0037833319511264563,
0.006544799543917179,
0.06058197095990181,
-0.00045238796155899763,
0.015011677518486977,
0.015741581097245216,
0.04963342472910881,
0.04785732552409172,
0.011331748217344284,
-0.036446504294872284,
-0.014147958718240261,
-0.0021015130914747715,
-0.015984881669282913,
-0.011897423304617405,
-0.029974695295095444,
0.027517354115843773,
-0.024962691590189934,
0.032796986401081085,
-0.01672695018351078,
-0.04080159217119217,
0.010182150639593601,
-0.0033210599794983864,
-0.017444688826799393,
0.03554629161953926,
-0.005383036565035582,
-0.0000772195853642188,
-0.01745685376226902,
0.0038593634963035583,
-0.009129873476922512,
-0.030388306826353073,
0.03790631145238876,
0.03564361110329628,
0.012615161947906017,
0.0023296079598367214,
-0.006763770245015621,
-0.02316226437687874,
0.010735660791397095,
0.019476251676678658,
0.017383862286806107,
-0.016568804159760475,
0.0032267807982861996,
-0.020157495513558388,
-0.0126516567543149,
-0.021726787090301514,
0.03335658088326454,
0.018576039001345634,
0.01850304752588272,
-0.015571270138025284,
0.023539381101727486,
-0.010918136686086655,
-0.008199246600270271,
0.01499951258301735,
0.0008865283452905715,
0.01105195190757513,
-0.012371860444545746,
0.005735823418945074,
-0.008010688237845898,
0.005559429991990328,
0.009859777055680752,
0.009227193892002106,
0.01246918085962534,
0.014573735184967518,
-0.023052778095006943,
0.03797930106520653,
-0.02132534049451351,
0.00008377731137443334,
-0.00816275179386139,
-0.030509958043694496,
-0.04097190499305725,
-0.014610230922698975,
-0.017566338181495667,
0.016945920884609222,
-0.022347206249833107,
0.010887724347412586,
-0.03016933612525463,
-0.011222262866795063,
0.0088683245703578,
-0.02379484660923481,
-0.007597076706588268,
0.01419661846011877,
0.021495651453733444,
0.028977159410715103,
0.02620352804660797,
0.00799852330237627,
0.012207631953060627,
-0.02525465376675129,
-0.027420032769441605,
0.009215028956532478,
-0.01759066991508007,
-0.0006143352366052568,
0.004114829935133457,
-0.04080159217119217,
-0.004996796138584614,
-0.005145817995071411,
-0.0028663910925388336,
-0.040825922042131424,
-0.010334214195609093,
0.015826735645532608,
-0.008752756752073765,
0.02150781638920307,
0.04014468193054199,
-0.002718889620155096,
0.022845972329378128,
0.006897585932165384,
-0.030047684907913208,
-0.014525075443089008,
-0.018795009702444077,
-0.014598065987229347,
0.01159937959164381,
-0.00831481534987688,
-0.002122801961377263,
-0.006252838298678398,
-0.03620320186018944,
0.034256793558597565,
-0.008114091120660305,
0.012663821689784527,
-0.027541683986783028,
-0.008028935641050339,
-0.0040175095200538635,
-0.0076579018495976925,
-0.010267306119203568,
0.0032602346036583185,
-0.0007766627240926027,
0.009671218693256378,
-0.013162589631974697,
-0.010005757212638855,
-0.030874907970428467,
0.02079007774591446,
-0.01614302769303322,
-0.008764921687543392,
0.0001589060266269371,
0.0246585663408041,
0.0181380957365036,
-0.0762019008398056,
-0.019756048917770386,
-0.010127408429980278,
-0.030193665996193886,
-0.00628933310508728,
0.011976496316492558,
-0.034573085606098175,
-0.007676149718463421,
0.03870920464396477,
-0.03053428791463375,
0.04919547960162163,
-0.036397844552993774,
0.018381398171186447,
-0.001473492244258523,
0.008655436336994171,
-0.01818675734102726,
-0.006423148792237043,
-0.04921980947256088,
-0.010772155597805977,
0.034159474074840546,
-0.01105195190757513,
0.019622232764959335,
-0.014804871752858162,
0.06267435848712921,
0.02296762354671955,
0.03369720280170441,
-0.009938850067555904,
0.005580718629062176,
-0.04106922447681427,
-0.012457015924155712,
0.02561960555613041,
0.014233114197850227,
-0.0019965895917266607,
0.02366103231906891,
-0.01632550358772278,
-0.038538891822099686,
0.018162427470088005,
-0.04812495782971382,
-0.005650667939335108,
-0.004811279010027647,
0.030558617785573006,
0.018989650532603264,
0.0005307004903443158,
0.011818350292742252,
-0.014671055600047112,
-0.019086970016360283,
-0.006715110037475824,
-0.008436465635895729,
0.023186594247817993,
-0.0007496714824810624,
0.019451921805739403,
-0.052942316979169846,
-0.020753582939505577,
-0.01276114210486412,
-0.012566501274704933,
-0.016155192628502846,
0.008971727453172207,
0.03610588237643242,
0.017700154334306717,
0.015242813155055046,
-0.036130212247371674,
0.046932779252529144,
-0.0215199813246727,
-0.006806347984820604,
-0.02006017602980137,
-0.010516690090298653,
-0.019026145339012146,
0.027128072455525398,
-0.04656783118844032,
-0.0040631284937262535,
-0.0023341698106378317,
-0.00914203841239214,
-0.029828714206814766,
0.034719064831733704,
0.023356905207037926,
0.011514224112033844,
-0.010626175440847874,
0.016945920884609222,
0.020181825384497643,
0.005252262577414513,
-0.009683383628726006,
-0.017651494592428207,
0.008886572904884815,
0.017420358955860138,
0.004473698791116476,
-0.017760979011654854,
0.04941445216536522,
-0.002807086333632469,
-0.002772111911326647,
-0.0037833319511264563,
-0.008655436336994171,
-0.011155354790389538,
-0.011058034375309944,
-0.00044516497291624546,
-0.002609404269605875,
-0.025692595168948174,
0.00392931280657649,
0.022870302200317383,
-0.033940501511096954,
-0.035984233021736145,
0.07055731862783432,
-0.025133002549409866,
-0.002556182211264968,
-0.01626467891037464,
-0.018162427470088005,
-0.0015327968867495656,
0.017432523891329765,
0.009488742798566818,
-0.0029180925339460373,
-0.0021897098049521446,
0.04257769137620926,
-0.02424495480954647,
0.01440342515707016,
-0.0057662357576191425,
-0.0002822672831825912,
-0.001944888150319457,
0.029342111200094223,
0.016118697822093964,
0.025741254910826683,
0.005367830395698547,
0.03722506761550903,
-0.007183464709669352,
-0.008558115921914577,
-0.003375802654772997,
0.001944888150319457,
-0.020498117431998253,
0.012116394937038422,
0.03698176518082619,
0.006027784664183855,
-0.018673358485102654,
-0.008923067711293697,
-0.013576201163232327,
-0.020473787561058998,
-0.01900181546807289,
-0.013478880748152733,
0.016763444989919662,
0.021118534728884697,
0.03141017258167267,
0.00632582837715745,
0.02415979839861393,
0.026544149965047836,
-0.001483376370742917,
0.006569129414856434,
-0.025862906128168106,
0.02802828513085842,
0.008448630571365356,
-0.022760817781090736,
0.039268795400857925,
0.005303964018821716,
-0.014245279133319855,
-0.030023355036973953,
0.02384350635111332,
0.034305453300476074,
0.08330629765987396,
-0.03294296935200691,
0.010717413388192654,
0.04447543993592262,
-0.01085122860968113,
-0.038222603499889374,
0.019305942580103874,
0.0042182328179478645,
0.032115742564201355,
-0.04476740211248398,
0.014963016845285892,
0.007724809926003218,
0.006061238702386618,
-0.02197008952498436,
-0.028831180185079575,
0.0004326197667978704,
0.012402273714542389,
0.011319583281874657,
-0.06184713914990425,
0.01599704660475254,
-0.00945833045989275,
-0.027590343728661537,
0.001511508016847074,
0.0563485324382782,
0.06247971951961517,
0.003251110902056098,
0.02014533057808876,
-0.03544896841049194,
0.01105195190757513,
-0.015279308892786503,
0.03515700623393059,
0.05391552299261093,
-0.02620352804660797,
-0.016605298966169357,
-0.018661193549633026,
0.01823541708290577,
0.020595436915755272,
-0.019816873595118523,
-0.006982741411775351,
0.02895282953977585,
0.04625153914093971,
0.04418347775936127,
-0.012116394937038422,
-0.006207219325006008,
0.014488579705357552,
-0.025084342807531357,
-0.0299990251660347,
-0.03586257994174957,
0.0420181006193161,
0.0506066270172596,
-0.004783907905220985,
-0.000839388754684478,
0.006532634142786264,
0.028831180185079575,
-0.04362388700246811,
0.010376791469752789,
0.04936579242348671,
0.015546940267086029,
0.035570621490478516,
-0.04557029530405998,
0.03313760831952095,
0.022590506821870804,
-0.01750551350414753,
0.0014484018320217729,
0.025595275685191154,
-0.018430057913064957,
-0.014488579705357552,
-0.011118859983980656,
-0.014245279133319855,
-0.005443862173706293,
-0.013734347186982632,
-0.014975182712078094,
-0.005154942162334919,
0.02119152620434761,
0.02634950913488865,
-0.005054580047726631,
-0.007919450290501118,
-0.018807174637913704,
0.002950025722384453,
0.0266171395778656,
0.020765747874975204,
-0.006642119958996773,
0.00023835904721636325,
-0.019245116040110588,
-0.010005757212638855,
0.012615161947906017,
-0.023393400013446808,
0.08223576843738556,
-0.020960388705134392,
-0.008843994699418545,
-0.026690129190683365,
-0.019999349489808083,
0.020364301279187202,
0.04274800047278404,
-0.018125930801033974,
-0.023965157568454742,
-0.0033910090569406748,
-0.017712319269776344,
0.01609436795115471,
0.0045740604400634766,
0.002134967129677534,
0.026179198175668716,
0.026227857917547226,
0.028514888137578964,
0.02729838341474533,
0.016690455377101898,
0.01664179563522339,
-0.012894958257675171,
0.02651982009410858,
0.030655937269330025,
-0.011313500814139843,
0.03265100717544556,
-0.026787450537085533,
0.016872931271791458,
0.010845146141946316,
0.037833321839571,
0.012955782935023308,
-0.009725960902869701,
0.015254979021847248,
0.009640805423259735,
0.017237883061170578,
-0.00813233945518732,
-0.0060642799362540245,
0.020850904285907745,
-0.028417568653821945,
-0.005297881551086903,
0.01832057163119316,
-0.012919288128614426,
0.017359532415866852,
-0.048879191279411316,
0.017237883061170578,
0.0025348933413624763,
-0.0015981841133907437,
-0.045691944658756256,
0.012773307040333748,
0.01737169735133648,
0.001316106878221035,
-0.02552228420972824,
0.041920777410268784,
-0.022322874516248703,
-0.0022885508369654417,
-0.01950058341026306,
-0.018393563106656075,
0.019111301749944687,
0.017493348568677902,
0.019841203466057777,
-0.004738288931548595,
0.03960941731929779,
0.013053103350102901,
-0.003914106171578169,
0.018770679831504822,
-0.009902354329824448,
-0.027736324816942215,
-0.04863588884472847,
-0.020984718576073647,
0.016386328265070915,
-0.0064474791288375854,
-0.027420032769441605,
-0.014950851909816265,
-0.009288019500672817,
-0.012213715352118015,
0.025911565870046616,
0.009172451682388783,
-0.03768733888864517,
-0.0034366280306130648,
0.020753582939505577,
0.0035217832773923874,
-0.00975029170513153,
0.0021973128896206617,
-0.013272074982523918,
-0.03668980672955513,
-0.04235871881246567,
0.01695808582007885,
-0.004212150350213051,
-0.03296729922294617,
0.006672532297670841,
-0.023442059755325317,
0.048781868070364,
-0.003406215226277709,
-0.008381722494959831,
0.007183464709669352,
-0.009215028956532478,
0.0061281463131308556,
0.016507979482412338,
-0.018746349960565567,
-0.007311197929084301,
0.011301335878670216,
0.0052948398515582085,
0.024220623075962067,
0.02766333520412445,
0.037176407873630524,
0.02019399031996727,
-0.009920601733028889,
-0.02297978848218918,
-0.02291896380484104,
0.005796648561954498,
0.007159134838730097,
0.05600791051983833,
-0.011471646837890148,
-0.04754103347659111,
0.030704598873853683,
-0.007706562057137489,
0.0070496490225195885,
0.0082235774025321,
-0.02352721616625786,
-0.006027784664183855,
-0.030655937269330025,
0.0014491621404886246,
0.04345357418060303,
0.022225555032491684,
-0.005568553693592548,
0.00411178870126605,
0.02630084753036499,
-0.027566013857722282,
-0.004285140428692102,
-0.02188493311405182,
-0.00161795224994421,
0.0035248245112597942,
0.026836110278964043,
-0.02926912158727646,
-0.014914357103407383,
-0.008874407038092613,
0.015048172324895859,
0.026179198175668716,
0.018563874065876007,
-0.017785310745239258,
0.01025514118373394,
0.007943781092762947,
-0.007238207384943962,
-0.030972229316830635,
-0.0007823650958016515,
0.017359532415866852,
-0.01833273656666279,
-0.015279308892786503,
-0.019622232764959335,
-0.0017228758661076427,
-0.010516690090298653,
0.009482660330832005,
-0.020169660449028015,
0.00009770059841684997,
-0.0219214279204607,
-0.04498637095093727,
0.0021440908312797546,
-0.0014704510103911161,
0.007809964939951897,
-0.001095615210942924,
0.02566826529800892,
-0.03396483138203621,
-0.002183627337217331,
-0.005431696772575378,
0.003938436508178711,
-0.016714785248041153,
0.01855170913040638,
0.04179912805557251,
-0.004951177164912224,
0.01632550358772278,
0.014062803238630295,
-0.02525465376675129,
0.010887724347412586,
-0.06350158900022507,
0.01458590105175972,
-0.020960388705134392,
0.011246592737734318,
0.01851521246135235,
0.01071133092045784,
-0.03649516403675079,
-0.015315803699195385,
0.008698014542460442,
0.016057871282100677,
-0.0037498781457543373,
-0.008211411535739899,
0.001306222751736641,
0.010036170482635498,
-0.003862404963001609,
-0.0008333062287420034,
-0.029244791716337204,
0.0299990251660347,
0.00623459042981267,
0.008424300700426102,
-0.002165379701182246,
-0.007590994238853455,
-0.029050150886178017,
-0.010443699546158314,
-0.013637026771903038,
0.0034761643037199974,
-0.024098973721265793,
0.0024436553940176964,
-0.021532146260142326,
0.02515733242034912,
0.04493771120905876,
0.016471484676003456,
-0.009227193892002106,
-0.012037321925163269,
-0.0469571128487587,
-0.0002204916236223653,
0.011988661251962185,
0.033843182027339935,
0.029609743505716324,
0.025643935427069664,
-0.025765586644411087,
-0.032699666917324066,
0.005732782185077667,
0.012311035767197609,
-0.017675824463367462,
-0.007870790548622608,
-0.002487753750756383,
0.013941152952611446,
-0.03586257994174957,
-0.02474372088909149,
0.02484104223549366,
0.007396353408694267,
0.012967947870492935,
-0.020181825384497643,
-0.01632550358772278,
0.004677463322877884,
-0.017031077295541763,
-0.004653133451938629,
0.007061814423650503,
0.023539381101727486,
0.046421848237514496,
0.03715207800269127,
0.013223414309322834,
-0.03036397695541382,
0.06350158900022507,
0.009294101968407631,
0.0033818851225078106,
0.004376378376036882,
-0.006112940143793821,
-0.015327968634665012,
-0.00808976124972105,
-0.020473787561058998,
-0.0010773676913231611,
0.00650830427184701,
-0.008174916729331017,
-0.03372153267264366,
0.03824693337082863,
-0.01900181546807289,
-0.005887886509299278,
-0.00979895144701004,
-0.00007940549403429031,
-0.010547102428972721,
-0.0007070938008837402,
0.01968305930495262,
0.031093880534172058,
-0.008150586858391762,
-0.0008827268029563129,
-0.011891340836882591,
-0.01918429136276245,
0.020656263455748558,
0.021483486518263817,
-0.007311197929084301,
0.024622071534395218,
0.0039931791834533215,
-0.023721856996417046,
-0.07571530342102051,
0.04016901180148125,
0.015559105202555656,
-0.026471158489584923,
-0.006976658944040537,
-0.004221274051815271,
0.007432848215103149,
0.03304028883576393,
-0.04968208447098732,
-0.00027200303156860173,
0.018563874065876007,
0.022262049838900566,
-0.01294361799955368,
0.017055407166481018,
0.006404901389032602,
0.01978037878870964,
-0.015364464372396469,
0.0022429318632930517,
-0.025060012936592102,
-0.031093880534172058,
0.007572746369987726,
-0.022310709580779076,
0.002645899308845401,
0.025400634855031967,
-0.008266154676675797,
0.010930301621556282,
-0.030728928744792938,
-0.03518133983016014,
0.013807336799800396,
-0.024378769099712372,
-0.018223252147436142,
0.005805772263556719,
-0.01210422907024622,
-0.004878187086433172,
-0.008801417425274849,
0.008241824805736542,
0.003345390083268285,
0.02351505123078823,
0.02639816887676716,
0.011988661251962185,
-0.01878284476697445,
0.029731392860412598,
-0.006593459751456976,
0.02457340992987156,
0.001511508016847074,
-0.019938524812459946,
-0.00558376032859087,
0.011562884785234928,
-0.014598065987229347,
0.018770679831504822,
-0.0034275040961802006,
-0.0180042814463377,
-0.01818675734102726,
0.00004951557275489904,
-0.01123442780226469,
0.016033541411161423,
0.005200560670346022,
0.01367352157831192,
0.007700479589402676,
-0.01959790289402008,
-0.01307743415236473,
-0.022955458611249924,
-0.014293938875198364,
-0.002054373500868678,
-0.024914031848311424,
-0.027103742584586143,
0.01121618039906025,
-0.024500420317053795,
-0.0011982579017058015,
0.009427917189896107,
-0.0034792055375874043,
-0.03532731905579567,
-0.004996796138584614,
0.008253989741206169,
0.0052279322408139706,
-0.016507979482412338,
0.021580807864665985,
-0.006818513385951519,
-0.0181380957365036,
-0.006246755365282297,
-0.017760979011654854,
0.010498441755771637,
0.007414600811898708,
-0.03367287293076515,
-0.016556639224290848,
0.035351648926734924,
0.017104066908359528,
-0.012457015924155712,
0.016605298966169357,
0.00018865338643081486,
0.011830516159534454,
-0.031093880534172058,
-0.01130741834640503,
0.004224315285682678,
0.018065106123685837,
-0.004796072840690613,
-0.017833970487117767,
0.007785635069012642,
-0.018430057913064957,
0.010005757212638855,
-0.011593297123908997,
-0.030436966568231583,
-0.0037924558855593204,
-0.017493348568677902,
0.00918461661785841,
-0.006921916268765926,
0.0009701630915515125,
-0.005012002307921648,
0.03021799586713314,
-0.04649483785033226,
0.013223414309322834,
-0.009744209237396717,
0.011830516159534454,
0.033843182027339935,
0.038490232080221176,
-0.019816873595118523,
0.009896271862089634,
-0.012505676597356796,
-0.005376954097300768,
-0.009032553061842918,
-0.02201874926686287,
0.039220135658979416,
-0.00235849991440773,
-0.03172646090388298,
0.04992538318037987,
-0.00605211453512311,
-0.0016057871980592608,
0.011258757673203945,
0.007797800004482269,
-0.010845146141946316,
0.018113765865564346,
-0.0506066270172596,
-0.005723658017814159,
-0.025911565870046616,
0.029196131974458694,
0.0030868826434016228,
0.003968849312514067,
-0.03741970658302307,
0.02269999124109745,
-0.021130699664354324,
-0.005757112056016922,
-0.015084668062627316,
0.025084342807531357,
-0.009543485008180141,
0.023989487439393997,
0.02288246713578701,
0.04007168859243393,
0.03345390036702156,
0.02156864106655121,
-0.026179198175668716,
0.04712742194533348,
-0.033478230237960815,
-0.0032298220321536064,
0.03807662054896355,
-0.017748814076185226,
0.0036525577306747437,
0.03997436910867691,
0.021167194470763206,
-0.007688314653933048,
0.006055155768990517,
0.004552771802991629,
-0.00701923668384552,
0.007524086162447929,
0.008028935641050339,
0.004735247697681189,
-0.0009192219586111605,
-0.0199628546833992,
0.10247842222452164,
-0.010717413388192654,
0.0040631284937262535,
0.007238207384943962,
0.0017821805085986853,
-0.013272074982523918,
0.028514888137578964,
0.018296241760253906,
0.021617302671074867,
0.01205556932836771,
0.0013906178064644337,
0.03386751189827919,
0.024500420317053795,
0.03323492780327797,
0.03255368769168854,
-0.02734704315662384,
-0.024013817310333252,
0.01714056171476841,
0.005617213901132345,
-0.006532634142786264,
0.010966796427965164,
0.012323200702667236,
-0.013564036227762699,
0.01745685376226902,
-0.018977485597133636,
0.01704324223101139,
0.019707389175891876,
0.029780054464936256,
0.012748977169394493,
0.030777588486671448,
0.02457340992987156,
0.0030747174751013517,
0.003433586796745658,
-0.030412636697292328,
-0.033745862543582916,
-0.05104456841945648,
-0.014792706817388535,
-0.019026145339012146,
0.008150586858391762,
0.014987347647547722,
0.012183302082121372,
-0.0177366491407156,
-0.012554336339235306,
0.010455864481627941,
0.023770516738295555,
-0.004720041062682867,
-0.022639166563749313,
0.017943454906344414,
-0.01246918085962534,
-0.019975019618868828,
0.001693983911536634,
0.028831180185079575,
0.026592809706926346,
-0.02006017602980137,
-0.023867838084697723,
-0.029366442933678627,
-0.00669078016653657,
0.00600649556145072,
-0.005650667939335108,
-0.02316226437687874,
0.024731555953621864,
0.006225466728210449,
0.0064657265320420265,
-0.0035309072118252516,
-0.0014255923451855779
] | 2024-06-29 | 158 | 38943167 | [
"CAR T cell therapy",
"CAR therapy",
"LNPs utility",
"traditional methods",
"LNPs",
"clinical trials",
"clinical considerations",
"chimeric antigen receptor",
"CAR",
"key challenges",
"Promising preclinical results",
"reduced toxicity",
"transformative actors",
"CAR) T cell therapy",
"challenges",
"safer and more effective CAR T cell treatments",
"Ongoing research",
"improved safety",
"Lipid nanoparticles",
"nucleic acids",
"immunogenicity",
"a new era",
"their effective delivery",
"these findings",
"a shift",
"the versatility",
"the preference",
"themselves",
"we"
] | [
"Chimeric antigen receptor",
"Immunotherapy",
"Lipid nanoparticles",
"Nonviral transduction",
"mRNA delivery"
] | 0 | 10.1186/s12951-024-02630-1
10.20517/2394-4722.2017.41
10.1016/j.semcancer.2011.12.004
10.1007/BF00299157
10.1186/s13045-023-01435-3
10.3390/cancers15010117
10.3389/fimmu.2022.1081546
10.1186/s12935-023-02923-9
10.1186/s13046-022-02327-z
10.1016/j.lfs.2023.121857
10.3389/fimmu.2021.669103
10.1038/nm.4441
10.1056/NEJMoa1804980
10.1056/NEJMoa1817226
10.1182/blood-2020-136834
10.1182/blood.2020008865
10.1056/NEJMoa2024850
10.1016/j.onano.2023.100124
10.3389/fimmu.2023.1203230
10.15419/bmrat.v9i2.726
10.3389/fimmu.2023.1113882
10.1097/PPO.0000000000000515
10.3390/ijms24076300
10.1016/j.ebiom.2021.103354
10.1038/s41467-022-32866-0
10.1038/s41467-020-19486-2
10.3389/fonc.2022.809754
10.3724/zdxbyxb-2022-0047
10.1016/j.omtm.2023.101139
10.1038/s41392-021-00487-6
10.3389/fimmu.2022.867013
10.1158/1541-7786.MCR-13-0244
10.3389/fimmu.2022.886546
10.1002/biot.201900286
10.1089/hum.2021.173
10.1038/s41586-022-05140-y
10.1016/j.iotech.2023.100375
10.1016/j.addr.2020.09.004
10.1007/s00262-014-1572-5
10.3390/cancers11081198
10.3389/fimmu.2019.02078
10.4110/in.2020.20.e14
10.1136/jitc-2020-001975
10.3389/fimmu.2022.925985
10.1002/btpr.3066
10.1016/j.jcyt.2021.03.002
10.1038/s41598-023-33941-2
10.1126/sciadv.abf1333
10.1007/s13770-022-00515-8
10.1038/s41467-022-33157-4
10.7150/thno.77259
10.1016/j.jconrel.2023.11.017
10.1038/s41467-022-31993-y
10.1016/j.ejpb.2014.02.005
10.1007/s00403-021-02256-5
10.1155/2022/1231446
10.1038/s41467-018-06936-1
10.1007/s11095-022-03166-5
10.1002/ange.202310395
10.1016/j.jconrel.2022.05.020
10.1021/acs.accounts.1c00500
10.7150/thno.89913
10.1021/acs.nanolett.9b04246
10.1002/ange.202405444
10.1038/s41541-023-00766-z
10.1073/pnas.2311276120
10.1016/j.canlet.2019.04.040
10.1039/D0BM01609H
10.1021/acs.nanolett.2c03741
10.1038/s41565-020-0669-6
10.1002/adma.201906128
10.1038/s41565-021-00928-x
10.1038/s41598-023-45197-x
10.3390/pharmaceutics13122097
10.1016/j.omtm.2023.06.005
10.1038/s44222-023-00138-1
10.1021/acs.nanolett.1c02503
10.1002/smll.202304378
10.1016/j.jconrel.2022.08.033
10.1016/j.jconrel.2022.11.038
10.2147/IJN.S424723
10.1002/adhm.202301515
10.1038/s41573-021-00283-5
10.1038/s42003-021-02441-2
10.1039/D1NR02065J
10.3389/fbioe.2022.882363
10.1038/s41598-023-43898-x
10.1016/j.omtn.2019.01.013
10.1038/s41590-022-01160-y
10.1038/s41590-022-01163-9
10.1038/s12276-023-01086-x
10.1038/s41467-022-32281-5
10.1016/j.jconrel.2022.03.033
10.1038/s41575-022-00729-0
10.1021/acsbiomaterials.1c01532
10.1186/s12915-021-01214-x
10.1002/anie.202008082
10.1126/science.abm0594
10.1016/j.ymthe.2021.06.004
10.1002/adma.201807748
10.1021/acsanm.0c01834
10.1016/j.bioelechem.2021.107871
10.1016/j.immuni.2018.01.007
10.1038/s41467-022-30896-2
10.1038/s41467-021-27434-x
10.1146/annurev-bioeng-070620-033348
10.1186/s12967-023-04553-1
10.1016/j.biomaterials.2021.121339
10.1021/acscentsci.1c00361
10.1073/pnas.1810002115
10.1016/j.ymthe.2018.07.010
10.1080/17425247.2019.1653851
10.1038/s41434-020-0132-1
10.1038/s41434-019-0095-2
10.1182/blood.2022019333
10.1038/nature18300
10.1021/acs.nanolett.5b02497
10.1073/pnas.2207841119
10.1016/j.jconrel.2018.02.043
10.1039/C8BM01262H
10.1002/adfm.202311920
10.1021/acsnano.5b02796
10.1073/pnas.1805358115
10.1002/adma.201606944
10.1002/med.21797
10.1016/j.apsb.2018.06.005
10.1053/j.gastro.2020.04.077
10.1039/D3NH00145H
10.1016/j.jconrel.2015.08.007
10.1089/nat.2018.0721
10.3390/pharmaceutics15030772
10.1073/pnas.2109256118
10.1007/s40820-023-01125-2
10.1038/mtna.2016.38
10.1016/j.jconrel.2023.03.041
10.1016/j.immuni.2021.11.001
10.1002/adma.202201095
10.1002/adfm.202204342
10.1038/s41578-022-00529-7
10.1021/acs.molpharmaceut.0c00854
10.1016/j.jconrel.2018.10.015
10.1021/acschembio.0c00003
10.1073/pnas.2116271119
10.1007/s12272-022-01418-x
10.1016/j.ijpharm.2021.120586
10.3390/polym14194195
10.1016/j.jconrel.2020.07.014
10.1158/0008-5472.CAN-12-2071
10.1016/j.vaccine.2013.11.069
10.1016/j.jconrel.2021.05.021
10.1016/j.jconrel.2022.06.017
10.1002/adma.202305300
10.1021/acsnano.2c04829
10.1039/D1BM00866H
10.1158/1538-7445.AM2023-836
10.1002/advs.202301929
10.1038/nbt.1602
10.1021/acs.nanolett.7b02664
10.1038/s41467-020-14527-2
10.1038/s41563-020-00886-0
10.1038/s41578-021-00358-0
10.1073/pnas.2301067120
10.1083/jcb.202110137
10.1016/j.jconrel.2022.01.008
10.1039/D0BM01947J
10.1158/1538-7445.AM2023-1785
10.1016/j.iotech.2022.100149
10.1007/s40005-022-00569-9 | [
"Khawar",
"Afzal",
"Si",
"Sun"
] | [
"Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China.\nJiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research Yangzhou, Yangzhou, China.\nApplied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan.",
"Shenzhen Institute of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, China.\nMolecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Sciences and Technology, University of Central Punjab, Lahore, Pakistan.",
"Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China.\nJiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research Yangzhou, Yangzhou, China.",
"Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China. [email protected].\nJiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research Yangzhou, Yangzhou, China. [email protected]."
] | [
"38943167",
"22210181",
"7638987",
"37029381",
"36612114",
"36741400",
"37158883",
"35361234",
"37307965",
"34367135",
"29155426",
"30501490",
"31042825",
"33534891",
"33626253",
"37520522",
"37020537",
"33750071",
"37047272",
"33910123",
"36064867",
"33247092",
"35223491",
"36161298",
"38027056",
"33558455",
"35757746",
"23928056",
"35677038",
"31642193",
"34662233",
"36045296",
"37124148",
"32931860",
"24938475",
"31426437",
"31555287",
"32395366",
"33741730",
"35936003",
"32808434",
"33941482",
"37185305",
"33853779",
"36867402",
"36151112",
"25409602",
"36438494",
"37956926",
"35879315",
"24530885",
"34146120",
"35941977",
"30374059",
"35080707",
"37651468",
"35569584",
"34668716",
"38164140",
"31951421",
"38637320",
"37919316",
"38079547",
"31100411",
"33404020",
"36521071",
"32251383",
"31999380",
"34140675",
"37875523",
"34959378",
"37564393",
"34669421",
"38072809",
"36002054",
"36423871",
"37873551",
"37602495",
"34433919",
"34381159",
"34132312",
"35747492",
"37798336",
"30785039",
"35332327",
"35288714",
"37779140",
"35970837",
"35337940",
"36646909",
"35104103",
"34996449",
"32662132",
"34990237",
"34091054",
"30748040",
"34147013",
"29466753",
"35773273",
"34907171",
"33863239",
"37794448",
"35078042",
"34341771",
"30201728",
"30078765",
"31387406",
"32111978",
"31300730",
"37294917",
"27281205",
"26469188",
"35969778",
"29518467",
"30633266",
"26042619",
"29891683",
"28681930",
"33666959",
"30766776",
"32569766",
"37427677",
"26264835",
"29683383",
"36986633",
"34933999",
"37269391",
"27327138",
"36972863",
"34852217",
"35218106",
"36691401",
"33492961",
"30336167",
"32155049",
"35173043",
"36422795",
"33839230",
"36236141",
"32681949",
"23074284",
"24295808",
"34019945",
"35716883",
"37547955",
"36511601",
"34647548",
"37092557",
"20081866",
"28836442",
"32080183",
"33542471",
"34394960",
"37364130",
"34882187",
"35016918",
"33586742",
"35369363"
] | [] | 9.954927 | 3.348954 |
38942219 | 794 | Management of bone disease with concurrent chimeric antigen receptor T-cell therapy for multiple myeloma. | In the intricate landscape of multiple myeloma, a hematologic malignancy of plasma cells, bone disease presents a pivotal and often debilitating complication. The emergence of Chimeric Antigen Receptor T-cell (CAR-T) therapy has marked a pivotal shift in the therapeutic landscape, offering novel avenues for the management of MM, particularly for those with relapsed or refractory disease. This innovative treatment modality not only targets malignant cells with precision but also influences the bone microenvironment, presenting both challenges and opportunities in patient care. In this comprehensive review, we aim to examine the multifaceted aspects of bone disease in patients with multiple myeloma and concurrent CAR-T therapy, highlighting its clinical ramifications and the latest advancements in diagnostic modalities and therapeutic interventions. The article aims to synthesize current understanding of the interplay between myeloma cells, CAR-T cells, and the bone microenvironment in the context of current treatment strategies in this challenging and unique patient population. | [
0.043415363878011703,
0.03646980971097946,
0.06312082707881927,
0.0574648380279541,
-0.0375557616353035,
0.01272597350180149,
0.0227596964687109,
-0.0034982287324965,
-0.016142189502716064,
-0.012126438319683075,
0.009914946742355824,
-0.04633385315537453,
-0.04323437437415123,
0.04495379328727722,
0.01110836025327444,
-0.017567498609423637,
0.024614861235022545,
0.008127654902637005,
0.05524769052863121,
0.03841547295451164,
-0.007901415228843689,
0.015248543582856655,
0.03574584424495697,
-0.02547457069158554,
-0.04348323494195938,
0.0118775749579072,
-0.035632725805044174,
0.011606087908148766,
-0.022386401891708374,
-0.008795061148703098,
-0.01576889492571354,
-0.02301987260580063,
-0.022205408662557602,
-0.006442170590162277,
-0.007318848744034767,
0.03699016198515892,
-0.005163917317986488,
0.007347128354012966,
0.0002292442659381777,
-0.005511760246008635,
0.03726164996623993,
0.038551215082407,
0.0115042794495821,
0.10189828276634216,
-0.0514921173453331,
0.014049474149942398,
-0.019332166761159897,
-0.05823405459523201,
0.016142189502716064,
-0.006102811079472303,
-0.02753335051238537,
0.02601754479110241,
-0.006165027152746916,
0.020372869446873665,
-0.02669626474380493,
0.022295905277132988,
0.0023246111813932657,
0.03128892555832863,
0.015101488679647446,
-0.01571233570575714,
-0.02278232015669346,
-0.021820802241563797,
-0.03995389863848686,
-0.003385108895599842,
-0.060632191598415375,
-0.012929588556289673,
-0.03818923234939575,
-0.014411457814276218,
-0.0071604810655117035,
0.015531343407928944,
0.021560626104474068,
-0.02699037455022335,
-0.014931808225810528,
0.014660321176052094,
0.034162167459726334,
-0.024162381887435913,
-0.03947879746556282,
0.010203402489423752,
-0.013755363412201405,
-0.018370648846030235,
0.021130772307515144,
-0.009355003945529461,
0.021820802241563797,
-0.02721661515533924,
-0.012952213175594807,
0.03653768450021744,
0.026651015505194664,
-0.02073485217988491,
-0.04642435163259506,
-0.004620942287147045,
-0.006481762509793043,
0.005540040321648121,
-0.03368706628680229,
0.03857383877038956,
-0.00025522647774778306,
0.051627859473228455,
0.0018806160660460591,
-0.06538322567939758,
0.008851621299982071,
0.05606215447187424,
0.03047446347773075,
0.02348366193473339,
-0.014671633020043373,
-0.013574371114373207,
0.06601669639348984,
-0.0115042794495821,
-0.024049261584877968,
-0.03070070408284664,
0.029660001397132874,
-0.026583144441246986,
0.023155614733695984,
-0.04617548733949661,
-0.015644462779164314,
0.049093976616859436,
-0.021560626104474068,
-0.028415683656930923,
-0.002721944358199835,
0.018144410103559494,
0.001349660218693316,
0.01773717813193798,
-0.011843639425933361,
0.03732952103018761,
0.007618615869432688,
-0.05827930197119713,
-0.0003103723574895412,
-0.005984035320580006,
0.05868653208017349,
-0.012137750163674355,
-0.031831901520490646,
-0.0414244569838047,
0.013336819596588612,
-0.010293898172676563,
0.020700916647911072,
-0.047374557703733444,
-0.06126566231250763,
0.023551534861326218,
-0.06610719114542007,
-0.0024660108610987663,
-0.04531577602028847,
-0.016809597611427307,
0.002020601648837328,
0.02778221294283867,
-0.011662647128105164,
0.0038913197349756956,
-0.0034133887384086847,
-0.02447911724448204,
0.012092502787709236,
0.0355648547410965,
0.007386720273643732,
0.027307109907269478,
-0.022578705102205276,
0.033076219260692596,
0.022895440459251404,
0.02245427295565605,
0.009422875940799713,
-0.057872071862220764,
-0.004940505605190992,
0.0485057532787323,
-0.02572343312203884,
-0.03583633899688721,
-0.013902419246733189,
-0.003880007890984416,
-0.00505928136408329,
-0.02800845354795456,
0.018415898084640503,
0.004307034891098738,
-0.027850085869431496,
0.05769107863306999,
-0.040361132472753525,
0.0009961609030142426,
-0.020689604803919792,
-0.029298018664121628,
-0.06488549709320068,
-0.02601754479110241,
-0.025361450389027596,
-0.00243490282446146,
0.017126332968473434,
-0.007154825143516064,
-0.052397072315216064,
-0.02545194700360298,
0.002152103465050459,
0.019117239862680435,
0.03678654506802559,
0.02977312169969082,
-0.019309543073177338,
0.014671633020043373,
-0.0247506033629179,
0.035361237823963165,
-0.027442853897809982,
-0.00399595545604825,
-0.011832327581942081,
0.02950163371860981,
0.04081360995769501,
0.017341259866952896,
0.0350671261548996,
0.007726079784333706,
0.03671867400407791,
0.0410398505628109,
-0.04581350460648537,
-0.03603995591402054,
0.05443323031067848,
-0.024117132648825645,
-0.032623738050460815,
0.01487524900585413,
-0.012952213175594807,
0.005972723476588726,
-0.014852624386548996,
0.027420230209827423,
-0.010271274484694004,
0.03468251973390579,
0.021945234388113022,
0.0028689999599009752,
0.008302990347146988,
0.03574584424495697,
-0.013302884064614773,
-0.041379209607839584,
-0.008778093382716179,
0.020802725106477737,
0.001027268823236227,
0.010599321685731411,
0.021289139986038208,
-0.004075139295309782,
0.015022304840385914,
0.0429176390171051,
-0.04922972247004509,
-0.007963631302118301,
0.0264926478266716,
-0.03674129769206047,
0.02144750766456127,
0.014660321176052094,
0.0072736009024083614,
-0.014931808225810528,
0.03929780423641205,
-0.02945638634264469,
-0.030067233368754387,
-0.028393059968948364,
0.005146949086338282,
0.02104027569293976,
0.050360918045043945,
0.003747092094272375,
0.019863830879330635,
0.0355648547410965,
0.06221586838364601,
-0.017680618911981583,
0.0005963532603345811,
-0.004963129758834839,
-0.016911404207348824,
-0.060360703617334366,
0.03400380164384842,
0.0282346922904253,
-0.010028067044913769,
0.024886347353458405,
-0.0182801540941,
0.011125328950583935,
0.014139970764517784,
0.002031913725659251,
-0.029388513416051865,
-0.010661537759006023,
0.024365996941924095,
0.003119277535006404,
0.00456438260152936,
0.012160374782979488,
-0.054387982934713364,
-0.04594924673438072,
-0.029908865690231323,
0.012669413350522518,
-0.018924936652183533,
-0.01998826116323471,
0.06370905041694641,
-0.0073754084296524525,
0.020112693309783936,
0.0335739441215992,
0.026673639193177223,
-0.032849978655576706,
-0.02775958925485611,
0.0036537682171911,
-0.0076808319427073,
0.03364181891083717,
0.030904319137334824,
0.022375088185071945,
0.03934305161237717,
0.010039378888905048,
0.023189552128314972,
-0.027148742228746414,
-0.011181888170540333,
-0.01499968022108078,
0.008563166484236717,
-0.011651335284113884,
-0.016085630282759666,
-0.0005482773412950337,
-0.009049581363797188,
0.017691930755972862,
0.0031645253766328096,
-0.01677566021680832,
-0.03280473127961159,
0.010571042075753212,
-0.015497407875955105,
-0.04049687460064888,
-0.0220131054520607,
0.06488549709320068,
-0.03527074307203293,
0.01323501206934452,
-0.03352869674563408,
-0.044637057930231094,
0.038551215082407,
0.01674172468483448,
-0.016096942126750946,
-0.037578385323286057,
0.008025847375392914,
0.021651122719049454,
-0.005647504236549139,
-0.046062368899583817,
0.05122062936425209,
0.025361450389027596,
0.005195024888962507,
0.006504386197775602,
0.01800866611301899,
-0.047103069722652435,
0.008082406595349312,
-0.05122062936425209,
-0.016877468675374985,
-0.018438521772623062,
-0.050089430063962936,
0.008495294488966465,
0.004465402569621801,
-0.03352869674563408,
0.01539559941738844,
-0.007166136987507343,
0.03076857514679432,
-0.07230614870786667,
-0.005865259561687708,
-0.03269161283969879,
0.0400443971157074,
-0.026899879798293114,
-0.011651335284113884,
-0.004216539207845926,
-0.0036113483365625143,
-0.028053700923919678,
0.019875142723321915,
-0.014524577185511589,
-0.001463486929424107,
0.02900390699505806,
-0.010373082011938095,
0.07755491137504578,
-0.010678505524992943,
-0.05592641234397888,
-0.008517918176949024,
0.008608413860201836,
-0.020180566236376762,
0.012703348882496357,
0.0013772330712527037,
-0.017409130930900574,
0.027374982833862305,
0.015022304840385914,
0.007533776108175516,
0.03671867400407791,
-0.05465947091579437,
-0.011244104243814945,
0.017126332968473434,
-0.02728448621928692,
0.013359444215893745,
-0.02097240462899208,
-0.04346061125397682,
0.05474996566772461,
0.05506670102477074,
0.08633299916982651,
-0.0153616638854146,
0.02272576093673706,
-0.023393167182803154,
-0.014219154603779316,
-0.01874394528567791,
-0.001788706285879016,
-0.00525724096223712,
0.006532666273415089,
-0.03370968997478485,
0.026424776762723923,
-0.010276930406689644,
-0.00013927870895713568,
-0.007590336259454489,
-0.03303097188472748,
0.03370968997478485,
-0.02153800241649151,
0.015859391540288925,
-0.019117239862680435,
-0.016888780519366264,
0.04226154461503029,
-0.005322284996509552,
0.00005757619146606885,
-0.06999851018190384,
0.028347812592983246,
-0.014230466447770596,
-0.010045034810900688,
-0.009383284486830235,
0.017838986590504646,
-0.017092395573854446,
0.07008900493383408,
-0.037352144718170166,
0.08171771466732025,
0.05470471829175949,
0.007590336259454489,
0.029162274673581123,
-0.029411138966679573,
0.002641346538439393,
-0.047148317098617554,
0.004493682645261288,
-0.029411138966679573,
0.027985829859972,
-0.01548609510064125,
0.00505928136408329,
-0.021605875343084335,
0.004058171529322863,
0.0025013608392328024,
0.04445606842637062,
0.02245427295565605,
0.027035623788833618,
-0.03708065673708916,
-0.037397392094135284,
0.06103942543268204,
-0.009711331687867641,
0.03868695721030235,
0.06755512207746506,
-0.0420353040099144,
0.02272576093673706,
-0.005104529205709696,
-0.0037555762100964785,
-0.013925042934715748,
0.06054169684648514,
0.015135424211621284,
0.018133098259568214,
-0.027080871164798737,
-0.029614754021167755,
0.050406165421009064,
0.019852519035339355,
-0.019603654742240906,
0.015158047899603844,
0.029931489378213882,
-0.05022517591714859,
0.0025423667393624783,
-0.012047254480421543,
-0.00021351355826482177,
-0.030067233368754387,
-0.014411457814276218,
-0.018178345635533333,
-0.014343585819005966,
0.051582612097263336,
0.023393167182803154,
0.01924167200922966,
0.0465148463845253,
-0.04594924673438072,
-0.015927262604236603,
-0.003116449574008584,
-0.040383756160736084,
-0.0018495081458240747,
0.01677566021680832,
-0.022567393258213997,
0.008981709368526936,
0.03599470853805542,
-0.047148317098617554,
0.016662541776895523,
0.044410817325115204,
0.04918447136878967,
-0.040089644491672516,
0.019931701943278313,
-0.04728405922651291,
0.01138550415635109,
0.023913517594337463,
0.03746526688337326,
-0.020384181290864944,
-0.02470535598695278,
-0.03149254247546196,
0.04981794208288193,
0.001691140467301011,
-0.013958978466689587,
0.028913412243127823,
-0.041356585919857025,
0.017691930755972862,
-0.010695473290979862,
0.023189552128314972,
0.05022517591714859,
0.016085630282759666,
-0.005667299963533878,
-0.01722813956439495,
-0.020700916647911072,
-0.0021407916210591793,
0.015621839091181755,
0.013925042934715748,
-0.04868674650788307,
0.02947901003062725,
-0.015802830457687378,
0.04305338114500046,
-0.023913517594337463,
-0.014309650287032127,
-0.012669413350522518,
-0.009202293120324612,
0.004943333566188812,
-0.020814036950469017,
-0.019807269796729088,
-0.055383436381816864,
-0.02850618027150631,
0.002471666783094406,
-0.021798178553581238,
0.03504450246691704,
0.008506606332957745,
0.022114913910627365,
0.011425095610320568,
0.06217062100768089,
-0.04493116959929466,
0.0651569813489914,
-0.013427316211163998,
0.053845006972551346,
-0.05570017173886299,
0.008308646269142628,
0.030949566513299942,
0.02927539497613907,
-0.006560946349054575,
-0.01602907106280327,
-0.030813822522759438,
-0.04366422817111015,
0.005313800647854805,
-0.015101488679647446,
-0.009043925441801548,
-0.003390764817595482,
-0.0010760517325252295,
-0.020271060988307,
0.04101722687482834,
0.0008243602933362126,
-0.024411244317889214,
0.006165027152746916,
-0.03330245986580849,
-0.004589834250509739,
0.010373082011938095,
-0.014287025667726994,
-0.018551640212535858,
0.026583144441246986,
-0.03653768450021744,
-0.019931701943278313,
-0.03717115521430969,
0.016900092363357544,
-0.03171878308057785,
-0.029388513416051865,
0.01825753040611744,
-0.042103175073862076,
-0.005636192392557859,
-0.006753250025212765,
0.007782639469951391,
0.019366104155778885,
0.010271274484694004,
-0.03242012485861778,
0.01702452450990677,
0.0003711742174346,
0.04450131580233574,
-0.024139758199453354,
-0.005605084355920553,
0.006985145155340433,
0.020678292959928513,
-0.025836553424596786,
-0.019637590274214745,
-0.037125907838344574,
-0.001617612550035119,
-0.015520031563937664,
-0.020700916647911072,
-0.007833543233573437,
-0.00028492038836702704,
-0.012963525019586086,
-0.04769129306077957,
0.022329840809106827,
-0.007398032583296299,
-0.02050861343741417,
-0.04072311520576477,
0.03128892555832863,
0.01364224310964346,
0.019626278430223465,
0.004790621809661388,
-0.0204633641988039,
0.020893219858407974,
-0.02597229741513729,
-0.016685165464878082,
0.04119821637868881,
0.013359444215893745,
0.003882835851982236,
-0.02150406688451767,
-0.04932021722197533,
-0.010814249515533447,
0.03932042792439461,
-0.020384181290864944,
0.013201076537370682,
-0.02321217581629753,
-0.02352891117334366,
-0.017793739214539528,
0.01947922259569168,
0.038890574127435684,
-0.0023147130850702524,
0.02746547758579254,
0.006204619072377682,
-0.0210176520049572,
0.025791306048631668,
0.005214821081608534,
-0.007471560500562191,
0.001768910326063633,
0.005797388032078743,
-0.005803043954074383,
-0.006917273625731468,
-0.023664655163884163,
-0.02373252622783184,
-0.006764561869204044,
0.053347278386354446,
0.016583357006311417,
0.014739505015313625,
0.010248650796711445,
0.0355648547410965,
0.02400401420891285,
0.06687640398740768,
-0.0282346922904253,
0.011606087908148766,
0.024908971041440964,
0.018574265763163567,
-0.016605980694293976,
-0.010412674397230148,
-0.01136288046836853,
-0.021311763674020767,
-0.002608824521303177,
0.012782532721757889,
0.005491964519023895,
-0.015870703384280205,
0.0157915186136961,
-0.057374343276023865,
-0.023076431825757027,
0.01978464610874653,
0.00886293314397335,
0.017556186765432358,
-0.024049261584877968,
-0.04244253411889076,
-0.014558513648808002,
0.02622116170823574,
0.013314195908606052,
-0.0001168315066024661,
0.0430307574570179,
-0.03244274854660034,
-0.017296012490987778,
-0.008404798805713654,
-0.0006242796662263572,
-0.004725578241050243,
-0.007793951779603958,
-0.008551853708922863,
0.02420762926340103,
-0.013664867728948593,
-0.0009282890241593122,
0.01751093938946724,
0.01222824677824974,
-0.03327983245253563,
0.01314451638609171,
-0.009077860973775387,
0.025678185746073723,
-0.0435284860432148,
0.0046775019727647305,
-0.017601434141397476,
-0.012409238144755363,
0.008902525529265404,
0.07995304465293884,
0.06122041493654251,
-0.02803107723593712,
0.03178665414452553,
-0.003387936856597662,
-0.020927155390381813,
-0.011323288083076477,
0.004411670845001936,
0.012160374782979488,
-0.008625381626188755,
0.013585683889687061,
0.004041203297674656,
0.0895456075668335,
0.019060680642724037,
-0.01901543140411377,
-0.012013318948447704,
0.036334067583084106,
0.010740721598267555,
0.026877256110310555,
-0.008172903209924698,
-0.03305359557271004,
0.019105928018689156,
0.011979382485151291,
-0.0018396101659163833,
-0.03952404484152794,
-0.06022496148943901,
-0.0006320566753856838,
0.006843745708465576,
0.023823022842407227,
0.02477322891354561,
0.021368322893977165,
-0.008167247287929058,
0.02425287663936615,
-0.011306320317089558,
-0.030859071761369705,
0.004451262764632702,
0.016391053795814514,
-0.03244274854660034,
-0.009592555463314056,
-0.025836553424596786,
0.004719922319054604,
-0.025904426351189613,
0.031040063127875328,
0.008721534162759781,
0.026560520753264427,
-0.03101743943989277,
0.047917529940605164,
-0.04305338114500046,
-0.005376016721129417,
-0.012205622158944607,
0.005904851481318474,
0.00962083600461483,
0.0021195814479142427,
-0.02400401420891285,
-0.007720423862338066,
-0.03425266593694687,
-0.0076638637110590935,
0.031831901520490646,
-0.015644462779164314,
0.03651506081223488,
-0.008206838741898537,
0.0309721902012825,
0.0182801540941,
0.022544769570231438,
-0.01100089680403471,
-0.0037414361722767353,
0.04117559269070625,
0.01999957486987114,
-0.051356371492147446,
0.03646980971097946,
-0.012906964868307114,
-0.022691823542118073,
-0.019366104155778885,
-0.01874394528567791,
-0.02551981806755066,
-0.03124367818236351,
-0.002512672683224082,
0.007409344427287579,
-0.0044258106499910355,
-0.027193991467356682,
-0.027691718190908432,
-0.001026561832986772,
0.0247506033629179,
-0.010904745198786259,
-0.04669583961367607,
0.002590442541986704,
-0.005353392567485571,
0.030564960092306137,
0.03020297735929489,
-0.006057563237845898,
-0.002473080763593316,
0.0007105335243977606,
-0.02024843730032444,
0.00699080154299736,
0.002221389440819621,
-0.016108253970742226,
0.0005599427968263626,
-0.027148742228746414,
-0.013800610788166523,
-0.007629928179085255,
-0.027420230209827423,
-0.028868163004517555,
-0.03450152650475502,
0.03470514342188835,
-0.014682944864034653,
-0.015927262604236603,
-0.004454090725630522,
-0.021390946581959724,
0.038551215082407,
0.0005959997652098536,
0.009162700735032558,
0.0013857170706614852,
-0.011606087908148766,
-0.014909184537827969,
0.016934027895331383,
-0.017872922122478485,
-0.0047877938486635685,
0.0008243602933362126,
-0.01537297572940588,
0.028868163004517555,
-0.004063827451318502,
-0.01596119813621044,
0.005655988119542599,
0.017861610278487206,
-0.011306320317089558,
0.0177258662879467,
0.006170683074742556,
0.019603654742240906,
0.012103814631700516,
-0.009711331687867641,
-0.019105928018689156,
0.011577807366847992,
-0.025859177112579346,
0.01398160308599472,
-0.031175807118415833,
-0.0014090480981394649,
-0.01727338694036007,
0.026583144441246986,
0.04504428803920746,
-0.0756092518568039,
-0.013698803260922432,
-0.016379741951823235,
0.00787313561886549,
-0.006764561869204044,
0.027442853897809982,
-0.038890574127435684,
-0.01235267799347639,
0.006176338996738195,
-0.02778221294283867,
0.010384393855929375,
0.004069483373314142,
0.0017858782084658742,
0.021673746407032013,
0.013811922632157803,
-0.032895226031541824,
-0.03619832545518875,
-0.029320642352104187,
-0.01901543140411377,
0.05230657756328583,
0.019535783678293228,
-0.004881117958575487,
-0.03979553282260895,
0.041085097938776016,
-0.018314089626073837,
0.006046251393854618,
-0.0013666281010955572,
-0.013800610788166523,
-0.050134677439928055,
-0.010407018475234509,
0.015553967095911503,
0.023868270218372345,
-0.01796341873705387,
0.04296288639307022,
0.0012697693891823292,
-0.011526904068887234,
0.029139650985598564,
-0.012216934002935886,
-0.02074616402387619,
0.013936354778707027,
-0.00039910065243020654,
0.042623527348041534,
0.030067233368754387,
0.02400401420891285,
-0.03443365544080734,
-0.02245427295565605,
-0.013698803260922432,
-0.003633972490206361,
0.011097048409283161,
-0.0070869531482458115,
-0.004391874652355909,
-0.026108041405677795,
-0.009886667132377625,
0.018359337002038956,
0.006046251393854618,
-0.011295008473098278,
-0.033868055790662766,
0.04407145828008652,
0.030293472111225128,
0.01651548594236374,
-0.009575587697327137,
0.02228459343314171,
0.03465989604592323,
0.006453482434153557,
-0.02373252622783184,
0.004490854684263468,
-0.040134891867637634,
0.005466512404382229,
-0.06149190291762352,
0.02321217581629753,
-0.027827462181448936,
-0.008936461061239243,
-0.015158047899603844,
0.009009988978505135,
0.0020460537634789944,
-0.005681440234184265,
-0.022103602066636086,
0.0002873948833439499,
-0.00399595545604825,
-0.002057365607470274,
-0.004889601841568947,
-0.04355110973119736,
-0.038845326751470566,
0.003594380570575595,
-0.04126609116792679,
-0.020599108189344406,
0.000032787054806249216,
0.011606087908148766,
0.019795957952737808,
-0.010769001208245754,
-0.010350458323955536,
-0.02104027569293976,
-0.02149275504052639,
0.012692037038505077,
-0.000837793224491179,
-0.016096942126750946,
-0.01803128980100155,
-0.017296012490987778,
0.023166926577687263,
-0.0272392388433218,
0.03721640259027481,
-0.023868270218372345,
0.014535889960825443,
-0.03400380164384842,
0.014072098769247532,
-0.0252483319491148,
0.02497684396803379,
-0.0012153304414823651,
-0.005384500604122877,
-0.013664867728948593,
0.025044715031981468,
-0.030293472111225128,
0.024614861235022545,
-0.019162487238645554,
0.012160374782979488,
0.00021086230117361993,
0.02472797967493534,
-0.020938467234373093,
0.02274838462471962,
-0.018449833616614342,
0.05280430614948273,
0.010531449690461159,
0.01138550415635109,
-0.0370580330491066,
0.014649009332060814,
-0.008099375292658806,
0.006855057552456856,
0.02323479950428009,
0.019139863550662994,
0.018585577607154846,
0.029569506645202637,
0.03970503807067871,
-0.006278146989643574,
-0.013947666622698307,
-0.003874351968988776,
0.03382280841469765,
0.004253303166478872,
0.018359337002038956,
0.010344802401959896,
0.021933922544121742,
-0.0036481122951954603,
0.006278146989643574,
0.01236398983746767,
-0.012318742461502552,
0.06407103687524796,
-0.021085523068904877,
-0.027555974200367928,
0.035632725805044174,
-0.020271060988307,
0.012793845497071743,
-0.009422875940799713,
0.012680725194513798,
0.030859071761369705,
0.065926194190979,
0.031085310503840446,
0.008099375292658806,
-0.0029241458978503942,
-0.03771412745118141,
-0.020044822245836258,
0.03479563817381859,
-0.049365464597940445,
0.055111948400735855,
-0.04094935581088066,
-0.03375493735074997,
-0.004736890085041523,
-0.00925319641828537,
0.028845539316534996,
-0.006905961316078901,
0.010067658498883247,
0.01050317008048296,
0.010859496891498566,
-0.036831796169281006,
0.04827951639890671,
-0.017816362902522087,
-0.00524310115724802,
0.021074211224913597,
0.006645786110311747,
-0.01725076325237751,
0.03452415019273758,
0.03133417293429375,
-0.03282735496759415,
-0.006244210992008448,
0.0006249867146834731,
0.03375493735074997,
0.007217040751129389,
-0.020056134089827538,
-0.018676072359085083,
-0.031085310503840446,
-0.005180885083973408,
0.015112800523638725,
-0.03223913162946701,
-0.050089430063962936,
0.02228459343314171,
0.0465148463845253,
0.045655135065317154,
-0.025904426351189613,
-0.012895653024315834,
0.04318912699818611,
-0.02346103824675083,
-0.014287025667726994,
-0.05280430614948273,
0.009332380257546902,
0.03868695721030235,
-0.01727338694036007,
-0.017624059692025185,
0.003006157698109746,
0.025316203013062477,
-0.0340716727077961,
-0.011040489189326763,
0.06040595471858978,
-0.01314451638609171,
0.03133417293429375,
-0.012692037038505077,
0.013189764693379402,
0.021809490397572517,
0.0008469842141494155,
0.0010908987605944276,
-0.010559730231761932,
-0.0008462772238999605,
-0.002702148398384452,
-0.03418479114770889,
-0.06782660633325577,
-0.006730625871568918,
-0.03920730948448181,
0.027691718190908432,
0.005887883715331554,
0.022137537598609924,
0.024139758199453354,
0.00030224185320548713,
0.0017378024058416486,
-0.01801997795701027,
0.029207522049546242,
0.024660108610987663,
0.02325742319226265,
0.014241778291761875,
0.008987365290522575,
-0.024343373253941536,
-0.02748810313642025,
0.005025345366448164,
-0.008721534162759781,
0.03465989604592323,
0.03778200224041939,
0.005771935917437077,
-0.048098523169755936,
-0.012590229511260986,
-0.014049474149942398,
0.04705782234668732,
-0.019807269796729088,
-0.018121786415576935,
-0.014207841828465462,
-0.017838986590504646,
0.03126630187034607,
0.011289352551102638,
0.03323458507657051,
0.02370990253984928,
0.009558619931340218,
0.017906857654452324,
0.001886271988041699,
0.014264401979744434,
0.0025777164846658707,
-0.01272597350180149,
0.0008787991828285158,
-0.015282480046153069,
0.00487546157091856,
0.0016105426475405693,
0.00611977931112051,
-0.007601648103445768,
-0.03122105449438095,
-0.004903741646558046,
0.035361237823963165,
0.0077091120183467865,
0.011560839600861073,
-0.04603974521160126,
0.006968177389353514,
0.011278040707111359,
-0.013857170939445496,
0.005791731644421816,
-0.0182801540941,
-0.007103920914232731,
0.0076242717914283276,
0.009321068413555622,
-0.009004333056509495,
-0.005757796112447977,
-0.011227136477828026,
0.03452415019273758,
0.03294047340750694,
-0.013857170939445496,
-0.004408842884004116,
-0.0009806068846955895,
-0.021176019683480263,
-0.01895887218415737,
0.00417977524921298,
0.0036056924145668745,
-0.0192190483212471,
0.001672758487984538,
-0.029660001397132874,
-0.005732343997806311,
-0.01703583635389805,
-0.00384607189334929,
-0.0059896912425756454,
-0.03465989604592323,
-0.0020870596636086702,
0.004581350367516279,
-0.021402258425951004,
0.012307430617511272,
-0.009847075678408146,
-0.022635264322161674,
-0.02796320617198944,
0.021843425929546356,
0.010192090645432472,
-0.03242012485861778,
0.010050690732896328,
0.010288242250680923,
-0.024298125877976418,
0.01137419231235981,
-0.00838783010840416,
-0.0157349593937397,
0.008597102016210556,
0.04275926947593689,
0.007743047550320625,
-0.0027643642388284206,
0.020271060988307,
-0.012126438319683075,
-0.010966961272060871,
-0.015497407875955105,
-0.0009304100531153381,
-0.0072736009024083614,
-0.006979489233344793,
-0.02551981806755066,
-0.028551427647471428,
-0.011651335284113884,
0.0001737448910716921,
0.02551981806755066,
-0.017691930755972862,
-0.008800717070698738,
-0.0016840704483911395,
-0.01001675520092249,
0.003404904855415225,
0.008789405226707458,
-0.00786182377487421,
0.0065383221954107285,
0.005503276363015175,
0.02502209134399891,
0.022420337423682213,
0.0018947559874504805,
0.0031305893789976835,
0.003732952056452632,
-0.012081190943717957,
-0.011119673028588295,
-0.014196529984474182,
0.05203508958220482,
-0.007149169221520424,
-0.04827951639890671,
0.03128892555832863,
0.02048598974943161,
-0.006238555070012808,
-0.01277122087776661,
0.011323288083076477,
0.0022892612032592297,
-0.006730625871568918,
-0.013495187275111675,
0.06678590923547745,
0.03882270306348801,
-0.02003351040184498,
0.00012549223902169615,
-0.001654376508668065,
-0.02778221294283867,
0.000418543117120862,
-0.01049751415848732,
0.0349540077149868,
0.013483875431120396,
-0.012205622158944607,
-0.009094828739762306,
0.0036368004512041807,
-0.00885727722197771,
-0.009462468326091766,
0.03692229092121124,
0.036107826977968216,
-0.00825208704918623,
0.05203508958220482,
-0.029818369075655937,
-0.015542655251920223,
0.0006037767161615193,
-0.03325720876455307,
-0.007550744339823723,
0.0015483268070966005,
-0.00399312749505043,
-0.0430307574570179,
0.015520031563937664,
-0.009524684399366379,
0.022895440459251404,
-0.012703348882496357,
0.021368322893977165,
0.0007571954047307372,
-0.018449833616614342,
-0.001561052748002112,
-0.022623952478170395,
-0.008585790172219276,
-0.007471560500562191,
0.016096942126750946,
0.005279865115880966,
-0.037103280425071716,
0.014468017965555191,
0.011775767430663109,
-0.0034897446166723967,
0.014366209506988525,
0.02348366193473339,
0.020836660638451576,
0.008851621299982071,
0.015904638916254044,
-0.027555974200367928,
0.000008622067980468273,
-0.04081360995769501,
0.026198536157608032,
-0.025655562058091164,
-0.003048577578738332,
0.029433762654662132,
-0.018099162727594376,
-0.022544769570231438,
-0.01447932980954647,
-0.003385108895599842,
-0.010672849602997303,
-0.0006430151406675577,
0.022420337423682213,
0.009813139215111732,
0.003885663812980056,
0.02447911724448204,
0.003028781618922949,
-0.022544769570231438,
0.000035173176001990214,
0.011130984872579575,
0.024795852601528168,
0.010045034810900688,
0.013020084239542484,
-0.030610207468271255,
0.0046124584041535854,
-0.020338933914899826,
0.014762128703296185,
-0.014920496381819248,
-0.0007522464147768915,
0.003102309536188841,
0.03626619651913643,
0.04556464031338692,
0.02952425740659237,
0.03282735496759415,
-0.02200179360806942,
-0.016164813190698624,
-0.0011354396119713783,
0.033347707241773605,
0.013087956234812737,
0.02574605867266655,
0.005152605008333921,
-0.03717115521430969,
-0.02123257890343666,
-0.020927155390381813,
-0.011617399752140045,
-0.012103814631700516,
-0.0036565964110195637,
0.02950163371860981,
0.02728448621928692,
-0.02271444909274578,
-0.011821014806628227,
0.0028831399977207184,
-0.008896869607269764,
0.030044609680771828,
-0.0039507076144218445,
-0.02778221294283867,
-0.003025953657925129,
-0.010186434723436832,
0.0012648203410208225,
0.022850191220641136,
0.022329840809106827,
0.005472168326377869,
-0.0037046722136437893,
0.003967675846070051,
-0.024886347353458405,
0.025610314682126045,
0.025859177112579346,
0.009207949042320251,
-0.013925042934715748,
-0.03140204772353172,
0.01950184628367424,
0.03542910888791084,
-0.011187544092535973,
0.01602907106280327,
0.029592130333185196,
-0.008235118351876736,
-0.016854844987392426,
0.034343160688877106,
-0.016119565814733505,
-0.02599492110311985,
0.012692037038505077,
-0.01721682772040367,
-0.005616396199911833,
-0.0019456598674878478,
0.008008879609405994,
-0.02425287663936615,
-0.018857063725590706,
-0.015802830457687378,
-0.010746377520263195,
-0.026651015505194664,
0.0047142659313976765,
-0.0007310364744625986,
-0.03024822473526001,
0.002932629780843854,
-0.030836448073387146,
-0.0656547099351883,
-0.050134677439928055,
0.006329050753265619,
-0.005426920484751463,
-0.004473886452615261,
-0.0115042794495821,
-0.037374768406152725,
0.018438521772623062,
0.04545152187347412,
-0.023551534861326218,
-0.005754968151450157,
0.04728405922651291,
0.02726186253130436,
-0.012205622158944607,
0.007171792909502983,
0.00799756683409214,
0.013348132371902466,
-0.002572060562670231,
-0.036605555564165115,
-0.006170683074742556,
0.004965957719832659,
0.03726164996623993,
-0.009496403858065605,
0.013517811894416809,
0.009847075678408146,
-0.002760122297331691,
0.026605768129229546,
0.006855057552456856,
-0.01548609510064125,
0.0157349593937397,
0.008597102016210556,
-0.010893433354794979,
-0.003614176530390978,
-0.010593665763735771,
-0.01061063352972269,
0.0075959921814501286,
0.00924188457429409,
-0.01312189269810915,
0.009021300822496414,
-0.01313320454210043,
0.035406485199928284,
-0.003597208531573415,
-0.02420762926340103,
0.012409238144755363,
0.024117132648825645,
-0.002894451841711998,
0.008088063448667526,
0.005916163790971041,
-0.0011778594925999641,
-0.014807377010583878,
-0.0003793046926148236,
0.02177555486559868,
-0.01971677504479885,
0.023936141282320023,
-0.020666981115937233,
-0.01401553861796856,
-0.004448434803634882,
0.013461251743137836,
-0.00835389457643032,
0.015667086467146873,
-0.01926429569721222,
0.018065225332975388,
-0.0011941205011680722,
0.03119843080639839,
-0.017307324334979057,
-0.00700211338698864,
-0.01949053443968296,
-0.020078757777810097,
-0.03049708716571331,
0.020101381465792656,
-0.018936248496174812,
-0.013189764693379402,
-0.009654771536588669,
-0.027193991467356682,
-0.005378844682127237,
-0.016549421474337578,
-0.026583144441246986,
0.011136640794575214,
-0.01099524088203907,
-0.01795210689306259,
-0.0011722035706043243,
-0.0194679107517004,
0.0036990162916481495,
0.004530446603894234,
-0.037578385323286057,
-0.009705675765872002,
0.008987365290522575,
-0.008433078415691853,
0.023913517594337463,
0.037872496992349625,
-0.028868163004517555,
0.009496403858065605,
-0.032352253794670105,
0.005313800647854805,
0.011719207279384136,
0.04070049151778221,
0.026130665093660355,
-0.02097240462899208,
0.005087561439722776,
-0.011453376151621342,
-0.0032267412170767784,
-0.023823022842407227,
-0.027193991467356682,
0.018574265763163567,
-0.008031503297388554,
-0.01676434837281704,
-0.018200969323515892,
-0.002300573280081153,
-0.0024688388220965862,
0.01773717813193798,
-0.042374663054943085,
-0.01578020676970482,
-0.005820011720061302,
0.0015935746487230062,
-0.0041345274075865746,
0.03377756103873253,
-0.04051949828863144,
-0.0004895964520983398,
-0.034388408064842224,
0.032148636877536774,
-0.02447911724448204,
-0.01848376914858818,
0.02051992528140545,
0.01136853639036417,
-0.013076644390821457,
0.014185218140482903,
0.017827674746513367,
-0.03875483199954033,
-0.010050690732896328,
-0.04764604568481445,
-0.0056616440415382385,
0.01699058897793293,
-0.0024306608829647303,
0.016832221299409866,
0.00121603743173182,
0.00837086234241724,
0.0004606095317285508,
0.028121573850512505,
-0.02604016847908497,
0.009807483293116093,
-0.03171878308057785,
-0.04891298711299896,
-0.026311656460165977,
-0.023189552128314972,
-0.041356585919857025,
-0.003594380570575595,
0.015983821824193,
0.021413570269942284,
0.04144708067178726,
0.0009049581130966544,
-0.012511045671999454,
0.02945638634264469,
-0.03180927783250809,
-0.017691930755972862,
0.011272384785115719,
-0.000969294982496649,
-0.013178451918065548,
-0.007137856911867857,
0.013676179572939873,
0.003119277535006404,
0.019151175394654274,
-0.004264615010470152,
0.0009721229434944689,
-0.012307430617511272,
-0.0024122789036482573,
0.017092395573854446,
-0.021605875343084335,
-0.004988581407815218,
0.12244082987308502,
-0.010865152813494205,
-0.004143011290580034,
-0.0015921606682240963,
-0.006838089786469936,
0.0011099876137450337,
0.019343478605151176,
0.002490048762410879,
0.005146949086338282,
0.002125237602740526,
-0.0004606095317285508,
0.03529336676001549,
0.03169615566730499,
0.05429748445749283,
0.03316671401262283,
-0.0027827462181448936,
0.016130877658724785,
0.03327983245253563,
-0.013958978466689587,
0.005630536004900932,
-0.00839914195239544,
0.012477110140025616,
-0.006696689873933792,
0.03359656780958176,
-0.016538109630346298,
-0.0059500993229448795,
0.00014670219388790429,
-0.021051587536931038,
-0.01100089680403471,
-0.028687171638011932,
-0.007420656271278858,
-0.0007108870195224881,
0.01745438016951084,
-0.0136196194216609,
0.004482370801270008,
-0.003368140896782279,
-0.016096942126750946,
-0.042103175073862076,
0.003939395770430565,
0.0074489363469183445,
-0.012137750163674355,
0.021877361461520195,
-0.00914007704705,
-0.0072622885927557945,
0.03176403045654297,
-0.002562162699177861,
-0.017103707417845726,
-0.005418436601758003,
0.008557509630918503,
-0.041605450212955475,
0.007924038916826248,
-0.028302565217018127,
0.009060893207788467,
0.013947666622698307,
-0.037374768406152725,
-0.0247506033629179,
-0.009428531862795353,
0.027374982833862305,
0.011119673028588295,
-0.016074318438768387,
-0.01898149587213993,
0.02048598974943161,
0.029840992763638496,
0.006006659474223852,
0.028438309207558632
] | 2024-06-29 | 1 | 38942219 | [
"myeloma cells",
"bone disease",
"malignant cells",
"plasma cells",
"multiple myeloma",
"current treatment strategies",
"current understanding",
"diagnostic modalities",
"therapeutic interventions",
"novel avenues",
"patient care",
"Chimeric Antigen",
"CAR-T cells",
"concurrent CAR-T therapy",
"the bone microenvironment",
"MM",
"Chimeric Antigen Receptor T-cell (CAR-T) therapy",
"relapsed or refractory disease",
"This innovative treatment modality",
"precision",
"patients",
"opportunities",
"the therapeutic landscape",
"a pivotal shift",
"this challenging and unique patient population",
"the intricate landscape",
"the latest advancements",
"the multifaceted aspects",
"its clinical ramifications",
"a hematologic malignancy"
] | [
"Chimeric antigen receptor T-cell therapy (CAR-T)",
"Multiple myeloma",
"Orthopedics",
"Surgery"
] | 0 | 10.1016/j.critrevonc.2024.104429 | [
"Kuruvilla",
"Huynh",
"Nester",
"Chose",
"Zervoudakis",
"Letson",
"Joyce",
"Binitie",
"Figura",
"Costello",
"Freeman",
"Lazarides"
] | [
"University of South Florida, Morsani College of Medicine, Tampa, FL, United States. Electronic address: [email protected].",
"University of South Florida, Morsani College of Medicine, Tampa, FL, United States. Electronic address: [email protected].",
"University of South Florida, Morsani College of Medicine, Tampa, FL, United States. Electronic address: [email protected].",
"University of South Florida, Morsani College of Medicine, Tampa, FL, United States. Electronic address: [email protected].",
"Department of Sarcoma, Moffitt Cancer Center, Tampa, FL, United States. Electronic address: [email protected].",
"Department of Sarcoma, Moffitt Cancer Center, Tampa, FL, United States. Electronic address: [email protected].",
"Department of Sarcoma, Moffitt Cancer Center, Tampa, FL, United States. Electronic address: [email protected].",
"Department of Sarcoma, Moffitt Cancer Center, Tampa, FL, United States. Electronic address: [email protected].",
"Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, United States. Electronic address: [email protected].",
"Department of Diagnostic Imaging and Intervention, Moffitt Cancer Center, Tampa, FL, United States. Electronic address: [email protected].",
"Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL, United States. Electronic address: [email protected].",
"Department of Sarcoma, Moffitt Cancer Center, Tampa, FL, United States. Electronic address: [email protected]."
] | [
"38942219"
] | [] | 4.940645 | 6.222513 |
38940301 | 795 | Immunotherapy with γδ T-cells: the future is there. | null | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | 2024-06-28 | 23 | 38940301 | [] | [
"DOT",
"adoptive cell therapy",
"bispecific T-cell engager",
"chimeric antigen receptor",
"delta one T-cells",
"immunotherapy",
"phosphoantigen",
"vitamin C, γδ T-cells"
] | 0 | 10.1080/1750743X.2024.2365622
10.1038/s41388-021-01811-8
10.3389/fimmu.2023.1212476
10.1080/14712598.2022.2064711
10.1038/s41586-023-06945-1
10.3390/biomedicines10123160
10.1182/blood.2022016200
10.1038/s41423-020-0515-7
10.3389/fimmu.2018.00800
10.1158/2326-6066.CIR-18-0647
10.1182/blood.2023022992
10.1126/scitranslmed.abj0835
10.1038/s41423-020-0504-x
10.3389/fimmu.2022.915837
10.1038/s41392-023-01653-8
10.1038/s41571-022-00722-1
10.1038/s41423-019-0247-8
10.1002/eji.202451028
10.1158/2326-6066.CIR-23-0189
10.1136/jitc-2022-005400
10.1038/s41467-023-42619-2
10.1111/imr.12925
10.1016/j.immuni.2023.07.018 | [
"Kabelitz",
"Yin"
] | [
"Institute of Immunology, Christian-Albrechts-University & University Hospital Schleswig-Holstein Campus Kiel, Kiel, 24105, Germany.",
"Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis & Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital affiliated with Jinan University, Jinan University, Zhuhai, 519000, China.\nState Key Laboratory of Bioactive Molecules & Druggability Assessment, The Biomedical Translational Research Institute, Health Science Center, School of Medicine, Jinan University, Guangzhou, 510632, China.\nKey Laboratory of Viral Pathogenesis & Infection Prevention & Control, Jinan University, Ministry of Education, Guangzhou, 510632, China."
] | [
"38940301",
"33947958",
"37691932",
"35414331",
"38383621",
"36551916",
"36416736",
"32939032",
"29725332",
"30894378",
"38437507",
"34669444",
"32699351",
"35784326",
"37989744",
"36624304",
"31171862",
"38616772",
"37368791",
"36162920",
"37938576",
"33048357",
"37703879"
] | [] | 32.972275 | 7.526498 |
38939825 | 796 | Nonsignaling extracellular spacer regulates tumor antigen selectivity of CAR T cells. | Advancing chimeric antigen receptor (CAR)-engineered T cells for the treatment of solid tumors is a major focus in the field of cellular immunotherapy. Several hurdles have hindered similar CAR T cell clinical responses in solid tumors as seen in hematological malignancies. These challenges include on-target off-tumor toxicities, which have inspired efforts to optimize CARs for improved tumor antigen selectivity and overall safety. We recently developed a CAR T cell therapy targeting prostate stem cell antigen (PSCA) for prostate and pancreatic cancers, showing improved preclinical antitumor activity and T cell persistence by optimizing the intracellular co-stimulatory domain. Similar studies were undertaken to optimize HER2-directed CAR T cells with modifications to the intracellular co-stimulatory domain for selective targeting of breast cancer brain metastasis. In the present study, we evaluate various nonsignaling extracellular spacers in these CARs to further improve tumor antigen selectivity. Our findings suggest that length and structure of the extracellular spacer can dictate the ability of CARs to selectively target tumor cells with high antigen density, while sparing cells with low antigen density. This study contributes to CAR construct design considerations and expands our knowledge of tuning solid tumor CAR T cell therapies for improved safety and efficacy. | [
0.024078674614429474,
-0.018087975680828094,
0.07165665179491043,
0.05640759691596031,
-0.05126278102397919,
-0.02275770902633667,
0.013116967864334583,
-0.0011239805025979877,
0.01362681481987238,
-0.002956242533400655,
-0.01721891760826111,
-0.028783170506358147,
-0.04507509246468544,
-0.006877138279378414,
0.022525960579514503,
-0.048528145998716354,
0.06590928882360458,
-0.004498818889260292,
0.02697553113102913,
0.010602496564388275,
0.032560672610998154,
-0.0016352757811546326,
-0.018400834873318672,
0.0036210711114108562,
-0.03545752912759781,
-0.006587452720850706,
0.027207281440496445,
0.023800576105713844,
0.0020698043517768383,
-0.008684776723384857,
0.0071146804839372635,
-0.025816788896918297,
-0.041506167501211166,
-0.028481896966695786,
-0.025098368525505066,
0.03930455446243286,
0.017612889409065247,
-0.003438569139689207,
-0.0015961681492626667,
-0.03223622590303421,
0.03689436987042427,
0.040092501789331436,
0.012468072585761547,
0.06461149454116821,
-0.052653271704912186,
0.007444922346621752,
-0.001544024795293808,
-0.0579371377825737,
0.015225879848003387,
0.0009030951769091189,
-0.03592102602124214,
0.011593221686780453,
-0.01879480853676796,
0.033255916088819504,
-0.05677839741110802,
-0.006517928093671799,
-0.04917704313993454,
-0.001855436828918755,
-0.01162798423320055,
0.015434454195201397,
-0.0026564178988337517,
-0.01412507425993681,
0.00307646207511425,
-0.022525960579514503,
-0.024912970140576363,
-0.009513278491795063,
-0.04679003357887268,
-0.006738089490681887,
0.00013968281564302742,
0.03381211310625076,
0.021135468035936356,
-0.023707877844572067,
-0.0012919981963932514,
0.022074049338698387,
0.02843554876744747,
-0.0069872187450528145,
0.0092467674985528,
0.047137655317783356,
0.012977919541299343,
-0.015608265064656734,
0.0073522231541574,
-0.020162124186754227,
0.026512034237384796,
-0.04157569259405136,
-0.03677849471569061,
-0.01648890972137451,
0.011981400661170483,
-0.0414598174393177,
-0.03656992316246033,
-0.02447264827787876,
-0.015040481463074684,
-0.010857420042157173,
-0.010799482464790344,
0.02597901225090027,
-0.003881788346916437,
0.021019594743847847,
-0.02827332355082035,
-0.056453946977853775,
0.05473900958895683,
0.02938571758568287,
0.06048637256026268,
-0.0060428436845541,
-0.04440302401781082,
-0.015422866679728031,
0.00773460790514946,
-0.011083374731242657,
-0.02811110019683838,
-0.003754326608031988,
0.018053213134407997,
-0.008244454860687256,
0.07012711465358734,
0.006929281633347273,
-0.012386959977447987,
0.07471573352813721,
-0.013267604634165764,
-0.0661410391330719,
-0.04903799295425415,
-0.0031691615004092455,
0.007531828247010708,
0.031147006899118423,
-0.008563108742237091,
0.03619912266731262,
0.04787925258278847,
-0.024333598092198372,
0.012746170163154602,
-0.02542281709611416,
0.09436801075935364,
-0.04201601445674896,
-0.05409011244773865,
-0.03594420105218887,
0.004684217739850283,
0.030451759696006775,
0.03473910689353943,
-0.004394532181322575,
-0.05863238498568535,
-0.0055619655176997185,
-0.053348518908023834,
-0.006071812007576227,
-0.013476178981363773,
-0.012537596747279167,
0.014913019724190235,
-0.021390391513705254,
0.02364994026720524,
-0.0004218547837808728,
-0.04280395805835724,
-0.049084343016147614,
-0.014994131401181221,
0.03707977011799812,
0.007479684427380562,
0.06896837055683136,
-0.02685965783894062,
0.04880624637007713,
0.07049790769815445,
0.010880595073103905,
0.0011536732781678438,
-0.034275609999895096,
-0.005063706077635288,
0.05385836586356163,
-0.04159886762499809,
-0.05195802450180054,
-0.012630295939743519,
0.032838769257068634,
-0.03504038229584694,
-0.011523696593940258,
0.021853888407349586,
-0.03263019770383835,
0.010527177713811398,
0.02387010119855404,
-0.08801810443401337,
-0.016558434814214706,
-0.036384522914886475,
-0.08231708407402039,
-0.06118161976337433,
-0.020602446049451828,
-0.028759995475411415,
0.0019162708194926381,
0.022016113623976707,
0.011413616128265858,
-0.012537596747279167,
-0.02231738530099392,
0.0057241893373429775,
0.03960582986474037,
0.04533001780509949,
0.006407847627997398,
-0.0012738928198814392,
0.053209468722343445,
-0.02514471858739853,
0.024681221693754196,
-0.036407697945833206,
-0.017473841086030006,
0.011083374731242657,
0.0027969153597950935,
0.06349910795688629,
0.003279241966083646,
-0.0194089412689209,
-0.02502884343266487,
0.025700915604829788,
0.040208373218774796,
-0.025052018463611603,
-0.004423500504344702,
0.02447264827787876,
-0.03450736030936241,
-0.04127441719174385,
0.028713645413517952,
-0.0028461620677262545,
-0.019721802324056625,
-0.03819216042757034,
0.04903799295425415,
0.0041801645420491695,
0.00928732380270958,
0.04838909953832626,
-0.030359061434864998,
-0.00040411154623143375,
0.01652367226779461,
-0.03891058266162872,
-0.03297781944274902,
0.011772826313972473,
0.033255916088819504,
0.009999950416386127,
0.001436116872355342,
-0.032444797456264496,
0.00510136503726244,
0.003728254931047559,
0.028157450258731842,
-0.03967535123229027,
0.01901496946811676,
-0.006749676540493965,
-0.03395116329193115,
-0.00365583342500031,
-0.02952476590871811,
-0.013453003950417042,
0.01141940988600254,
0.004249689169228077,
-0.020498160272836685,
-0.04716083034873009,
-0.017612889409065247,
0.04419444873929024,
-0.012943156994879246,
0.0703125149011612,
-0.02683648280799389,
-0.007265317253768444,
0.015874776989221573,
0.03492450714111328,
-0.02757807821035385,
-0.003209717571735382,
-0.002654969459399581,
-0.021633727476000786,
-0.06558483839035034,
0.017195742577314377,
-0.004588621202856302,
0.01993037573993206,
-0.006796026602387428,
-0.01660478487610817,
-0.0009378574322909117,
0.02669743448495865,
0.02597901225090027,
0.024240899831056595,
-0.01981450244784355,
0.01746225357055664,
-0.05242152512073517,
-0.003482022089883685,
0.016593197360634804,
-0.008279217407107353,
-0.056036800146102905,
-0.04593256488442421,
0.0055967275984585285,
0.011147105135023594,
0.012838870286941528,
0.01746225357055664,
-0.011830763891339302,
0.06780962646007538,
0.01943211629986763,
0.00556486239656806,
0.00005879714444745332,
-0.08509807288646698,
0.016975581645965576,
-0.03163367882370949,
0.03633817285299301,
-0.0024449473712593317,
0.002353696385398507,
-0.03534165397286415,
0.015063656494021416,
0.0032821388449519873,
-0.005472162738442421,
-0.00618768623098731,
-0.016199223697185516,
0.010335985571146011,
-0.008887557312846184,
0.014762382954359055,
-0.054460909217596054,
0.013858563266694546,
-0.015700964257121086,
-0.030057787895202637,
-0.009843519888818264,
-0.010776307433843613,
-0.002649175701662898,
-0.025121543556451797,
-0.024797094985842705,
-0.013661577366292477,
0.01646573469042778,
-0.025121543556451797,
0.014785557985305786,
0.005944350268691778,
-0.04011567682027817,
0.023580415174365044,
0.015388104133307934,
0.03320956975221634,
-0.013951263390481472,
0.02106594294309616,
0.02140197902917862,
0.030196836218237877,
-0.027925701811909676,
0.012896806932985783,
0.0033140042796730995,
0.010677814483642578,
-0.0032184079755097628,
0.02813427522778511,
-0.03360354155302048,
0.023846926167607307,
-0.04384682700037956,
-0.06164511665701866,
-0.005672045983374119,
-0.04688273370265961,
0.0018641274655237794,
0.043313805013895035,
-0.03311686962842941,
0.01857464760541916,
0.0000774456566432491,
0.023962801322340965,
-0.036685798317193985,
0.029779689386487007,
-0.0346464104950428,
0.06915377080440521,
-0.013093793764710426,
0.011680127121508121,
-0.033557191491127014,
-0.03867883235216141,
-0.030729858204722404,
0.013418241403996944,
0.01881798356771469,
-0.0301041379570961,
0.015538740903139114,
-0.040370598435401917,
0.036685798317193985,
0.01951322890818119,
0.006332529243081808,
0.011384648270905018,
0.002466673729941249,
-0.0025304045993834734,
0.008290804922580719,
0.0048232669942080975,
0.02769395336508751,
0.00650054682046175,
0.00035613233922049403,
-0.021807538345456123,
0.04787925258278847,
-0.012549184262752533,
-0.0415293425321579,
0.02994191274046898,
-0.010469241067767143,
0.049964990466833115,
0.005141920875757933,
-0.020162124186754227,
0.02771712653338909,
0.03473910689353943,
0.07930435240268707,
-0.02159896492958069,
0.056732047349214554,
-0.009113512001931667,
-0.01626874879002571,
-0.020498160272836685,
0.009571215137839317,
0.05510980635881424,
-0.015735726803541183,
-0.03251432254910469,
0.03932772949337959,
0.01096170675009489,
0.032722897827625275,
0.028157450258731842,
-0.03884105756878853,
0.06595563888549805,
-0.021633727476000786,
-0.02289675734937191,
-0.04609478637576103,
0.008505172096192837,
0.012746170163154602,
0.055897749960422516,
0.00197131116874516,
-0.11123930662870407,
-0.003516784403473139,
-0.01965227723121643,
-0.031031131744384766,
-0.007560796570032835,
0.004099052399396896,
-0.01990720070898533,
0.052931372076272964,
-0.01162798423320055,
0.0465119369328022,
0.05594410002231598,
0.013059031218290329,
0.013105381280183792,
-0.03351084142923355,
-0.018667345866560936,
-0.012954744510352612,
0.011234011501073837,
-0.035990551114082336,
0.02980286441743374,
0.013406653888523579,
0.011969813145697117,
-0.03107748180627823,
-0.0019177192589268088,
-0.011923463083803654,
0.04491287097334862,
0.027045056223869324,
-0.026118062436580658,
-0.01929306797683239,
-0.019397353753447533,
0.015133180655539036,
-0.0034240849781781435,
0.022085636854171753,
0.05594410002231598,
-0.020973244681954384,
0.02419454976916313,
-0.015260642394423485,
-0.01130932942032814,
0.00561990262940526,
0.01013320591300726,
0.018412422388792038,
-0.01250283420085907,
-0.07772846519947052,
-0.033163219690322876,
0.07619892805814743,
0.009154068306088448,
0.006205067504197359,
-0.0360369011759758,
0.015735726803541183,
-0.01873687095940113,
0.037937238812446594,
-0.0424099862575531,
0.012340610846877098,
-0.050104036927223206,
-0.017276855185627937,
0.0072421422228217125,
-0.027879351750016212,
0.03269972279667854,
-0.00028642674442380667,
0.009194623678922653,
0.040347423404455185,
-0.026882832869887352,
-0.012329023331403732,
-0.030729858204722404,
-0.03246797248721123,
-0.015353341586887836,
0.016361448913812637,
-0.02954794093966484,
0.009032400324940681,
0.038539785891771317,
-0.06326735764741898,
-0.008406679145991802,
0.04171473905444145,
0.0670216828584671,
-0.05177262797951698,
-0.01119924895465374,
-0.035550229251384735,
0.0016932128928601742,
0.04298935830593109,
0.036963894963264465,
-0.019061319530010223,
-0.004591518081724644,
-0.033580366522073746,
0.019188780337572098,
-0.021992938593029976,
-0.01447269693017006,
0.0014158388366922736,
-0.0015643027145415545,
0.029061269015073776,
0.015249054878950119,
0.009072955697774887,
0.0248666200786829,
-0.0027244938537478447,
-0.01534175407141447,
-0.006245623808354139,
-0.017357967793941498,
0.03409021347761154,
0.036824844777584076,
0.04097314551472664,
-0.016917644068598747,
0.023626765236258507,
-0.006993012502789497,
0.022386910393834114,
-0.012966332025825977,
-0.012722996063530445,
0.0085515221580863,
-0.010086855851113796,
-0.020115774124860764,
-0.041343942284584045,
0.004771123174577951,
0.01694081909954548,
-0.036546748131513596,
0.023499304428696632,
0.02126293070614338,
0.04352238029241562,
-0.023267555981874466,
0.01370792742818594,
0.04461159557104111,
0.04111219570040703,
0.023360254243016243,
0.0733252465724945,
0.011853938922286034,
0.030868908390402794,
-0.03816898539662361,
-0.028342848643660545,
0.02769395336508751,
0.0043481821194291115,
-0.019547991454601288,
-0.010625671595335007,
-0.022352147847414017,
0.01640779711306095,
-0.0020958760287612677,
-0.0031170181464403868,
-0.009437959641218185,
-0.01793733797967434,
0.0153996916487813,
0.02375422790646553,
0.021216580644249916,
-0.03886423259973526,
-0.04421762377023697,
-0.07652337104082108,
-0.053070418536663055,
-0.04590938985347748,
0.024403123185038567,
-0.014159836806356907,
0.029640641063451767,
0.016500497236847878,
-0.012607121840119362,
-0.011297741904854774,
-0.036407697945833206,
0.042178235948085785,
-0.006993012502789497,
-0.02361517772078514,
0.011210836470127106,
-0.01119924895465374,
0.00823286734521389,
0.004359769634902477,
-0.005359185393899679,
0.016836533322930336,
0.007682464551180601,
-0.03168002888560295,
0.020057838410139084,
-0.015654614195227623,
0.027624428272247314,
-0.04461159557104111,
0.02994191274046898,
0.0032966232392936945,
0.02026641182601452,
-0.012838870286941528,
-0.015643026679754257,
-0.03833121061325073,
-0.024773919954895973,
-0.012850457802414894,
-0.036546748131513596,
-0.004591518081724644,
0.023777401074767113,
-0.02894539386034012,
-0.007016187533736229,
0.028806345537304878,
0.005422916263341904,
0.0015860291896387935,
-0.03536482900381088,
0.013116967864334583,
0.007300079334527254,
0.0020741496700793505,
0.0037572234869003296,
-0.019941963255405426,
0.06428705155849457,
-0.0028302292339503765,
-0.018899094313383102,
0.021668490022420883,
0.005472162738442421,
0.013754276558756828,
-0.015411279164254665,
-0.024611696600914,
0.0012985161738470197,
0.052375175058841705,
-0.010677814483642578,
0.011141312308609486,
-0.04185378924012184,
0.0030909464694559574,
-0.000438873830717057,
0.0048174732364714146,
0.012641883455216885,
-0.013325542211532593,
0.044055402278900146,
0.004104846157133579,
-0.033140044659376144,
-0.009710264392197132,
-0.009802963584661484,
-0.012027749791741371,
-0.014519046992063522,
-0.009235179983079433,
0.010787894949316978,
-0.010967500507831573,
0.013418241403996944,
-0.03902645781636238,
-0.02954794093966484,
0.006674358621239662,
-0.0031575739849358797,
-0.027624428272247314,
0.027299979701638222,
0.007850482128560543,
0.03320956975221634,
0.0410194955766201,
-0.03040541149675846,
0.02855142205953598,
0.010359160602092743,
0.013951263390481472,
-0.04159886762499809,
-0.03133240342140198,
0.012294260784983635,
-0.03548070415854454,
-0.011900288052856922,
-0.00210022134706378,
-0.013823801651597023,
0.021251343190670013,
-0.0020857369527220726,
-0.02827332355082035,
-0.010399716906249523,
-0.013812214136123657,
0.028296498581767082,
0.019003381952643394,
-0.008441440761089325,
-0.04083409532904625,
0.0039571067318320274,
0.04560811445116997,
-0.011946638114750385,
-0.027948874980211258,
0.036917544901371,
-0.009837726131081581,
-0.00961756519973278,
0.011535284109413624,
-0.0184935349971056,
0.02725362963974476,
0.011680127121508121,
-0.019965138286352158,
0.011859732680022717,
-0.024055499583482742,
-0.011564252898097038,
0.022549133747816086,
-0.0027505657635629177,
-0.01100226305425167,
-0.018505122512578964,
-0.008736920543015003,
0.023823751136660576,
-0.015434454195201397,
0.021668490022420883,
-0.007763576693832874,
0.026766957715153694,
-0.0101621737703681,
0.046558283269405365,
0.04621066153049469,
-0.034275609999895096,
0.02869047038257122,
-0.028366023674607277,
0.004298935644328594,
0.008626840077340603,
-0.016709070652723312,
0.0052809701301157475,
0.016651133075356483,
0.01115869265049696,
-0.008360329084098339,
0.06739248335361481,
0.02247961051762104,
0.019721802324056625,
-0.020393872633576393,
-0.004968109540641308,
0.010840038768947124,
-0.005060809198766947,
-0.010150587186217308,
-0.01721891760826111,
0.010990675538778305,
-0.005770538933575153,
0.01462333370000124,
-0.013974437490105629,
-0.05993017554283142,
-0.01921195536851883,
-0.0028302292339503765,
-0.010585115291178226,
0.03263019770383835,
0.010405509732663631,
0.005773435812443495,
0.011274566873908043,
-0.026210762560367584,
-0.013615227304399014,
-0.006703326944261789,
0.022131986916065216,
0.02387010119855404,
-0.01126877311617136,
-0.008001118898391724,
-0.001018969458527863,
-0.028759995475411415,
0.024797094985842705,
0.01563144102692604,
0.01907290704548359,
-0.0177982896566391,
0.0005073120701126754,
-0.010932737961411476,
-0.008875969797372818,
-0.009223592467606068,
0.006604833994060755,
0.03490133211016655,
0.0035138875246047974,
-0.0020582168363034725,
-0.03661627322435379,
-0.019119255244731903,
0.005628593266010284,
0.0013311058282852173,
0.0038528197910636663,
0.026210762560367584,
0.022108811885118484,
0.011251392774283886,
-0.005648870952427387,
-0.011170280165970325,
-0.030289536342024803,
0.0156198525801301,
0.02882952056825161,
0.029571115970611572,
-0.03052128478884697,
0.04312840476632118,
-0.03629182279109955,
0.02225944958627224,
-0.0021349836606532335,
-0.004403222352266312,
-0.03432196006178856,
0.006094987038522959,
-0.019837675616145134,
0.016430972144007683,
-0.020660383626818657,
-0.01534175407141447,
-0.012815695255994797,
0.002149467822164297,
0.0433601550757885,
-0.024982495233416557,
-0.02132086642086506,
0.01243331003934145,
-0.006772851571440697,
0.03223622590303421,
0.02217833697795868,
0.01596747525036335,
0.022502785548567772,
-0.03923502936959267,
-0.0007843240164220333,
0.007908419705927372,
-0.004099052399396896,
-0.005822682287544012,
-0.018980206921696663,
-0.024634871631860733,
0.0010015883017331362,
0.018030038103461266,
0.010619877837598324,
-0.023638352751731873,
0.008957081474363804,
-0.0153996916487813,
-0.009669708088040352,
0.025260591879487038,
0.0033922195434570312,
0.02259548380970955,
0.014716032892465591,
0.011425203643739223,
0.00005540238998946734,
0.01566620171070099,
-0.005483750253915787,
-0.015075244009494781,
-0.011065993458032608,
-0.020590858533978462,
-0.005883516278117895,
0.0020249029621481895,
-0.03587467595934868,
0.00942637212574482,
-0.025098368525505066,
0.010793688707053661,
-0.010926944203674793,
0.00972764566540718,
-0.02084578201174736,
0.017357967793941498,
0.0019626205321401358,
-0.02170325256884098,
-0.00635570427402854,
0.01644255965948105,
-0.010561940260231495,
-0.027531728148460388,
-0.012746170163154602,
0.034136563539505005,
-0.04039377346634865,
0.04136711731553078,
-0.014298886060714722,
0.006755470298230648,
0.04023154824972153,
-0.0799069032073021,
-0.03575880080461502,
0.021251343190670013,
-0.0014723275089636445,
-0.018261786550283432,
-0.0015874776290729642,
-0.018192261457443237,
-0.00723634846508503,
0.02952476590871811,
-0.0147044463083148,
0.02544599212706089,
-0.010417097248136997,
0.03867883235216141,
0.00950748473405838,
-0.01434523519128561,
-0.04792560264468193,
-0.021251343190670013,
-0.05965207889676094,
-0.019687039777636528,
0.016071762889623642,
0.009559627622365952,
0.01815749891102314,
-0.0031315023079514503,
0.039374079555273056,
-0.0026853864546865225,
0.009808757342398167,
-0.03205082565546036,
-0.03260702267289162,
-0.05863238498568535,
-0.031147006899118423,
0.0010175210190936923,
0.030753033235669136,
-0.002711458131670952,
0.029038093984127045,
-0.007636114954948425,
-0.03297781944274902,
0.028783170506358147,
-0.007045156322419643,
-0.0037311518099159002,
-0.008887557312846184,
0.014078725129365921,
-0.008389297872781754,
0.0203243475407362,
0.025608215481042862,
-0.019061319530010223,
-0.016929231584072113,
-0.038539785891771317,
-0.00681340740993619,
0.006181892938911915,
0.006836582440882921,
0.036222297698259354,
-0.02364994026720524,
-0.024078674614429474,
0.019687039777636528,
-0.006320941727608442,
-0.014403172768652439,
-0.0008429853478446603,
0.006674358621239662,
0.015017306432127953,
0.018922269344329834,
-0.023916451260447502,
0.05409011244773865,
0.039211854338645935,
0.0036007931921631098,
-0.008980256505310535,
-0.007891038432717323,
-0.041737914085388184,
0.011604809202253819,
-0.033163219690322876,
0.01935100369155407,
-0.023962801322340965,
0.0072421422228217125,
-0.04732305556535721,
0.041042670607566833,
-0.0006184789817780256,
0.020532922819256783,
-0.018899094313383102,
-0.009860901162028313,
0.004849338438361883,
0.022363735362887383,
0.013673164881765842,
0.004814576357603073,
-0.014982543885707855,
0.005373669788241386,
-0.03673214465379715,
-0.01835448481142521,
0.008186518214643002,
0.00939740426838398,
-0.001882957061752677,
-0.021297693252563477,
0.0056981174275279045,
-0.013962850905954838,
0.008760095573961735,
-0.0018873022636398673,
-0.006622214801609516,
-0.013163317926228046,
0.004194648936390877,
0.0010906666284427047,
0.006975631695240736,
-0.011147105135023594,
0.07128585875034332,
-0.02475074492394924,
-0.01024328637868166,
-0.028018400073051453,
-0.04308205842971802,
0.0027418751269578934,
0.058307938277721405,
0.020417047664523125,
-0.0005406259442679584,
-0.016720658168196678,
0.03636134788393974,
0.017288442701101303,
0.012595534324645996,
-0.005582243204116821,
0.006993012502789497,
0.012213149107992649,
0.02655838429927826,
-0.025515515357255936,
0.03082255832850933,
-0.013174905441701412,
0.06757787615060806,
0.007415954023599625,
0.005356288515031338,
-0.022966282442212105,
-0.0011703302152454853,
0.0026795926969498396,
-0.0018641274655237794,
0.02414819970726967,
-0.009455340914428234,
0.002592687029391527,
0.030729858204722404,
0.025214243680238724,
0.007728814147412777,
-0.022827232256531715,
-0.011465759947896004,
0.05413646250963211,
0.00806484930217266,
0.034391485154628754,
-0.005758951418101788,
0.005475059617310762,
-0.00559962447732687,
-0.02283881977200508,
0.0053070420399308205,
-0.015260642394423485,
0.0312397051602602,
-0.005049221683293581,
-0.05677839741110802,
-0.01145996619015932,
0.01594430021941662,
0.007259523496031761,
-0.01320966798812151,
0.013939675875008106,
0.03645404800772667,
0.03575880080461502,
-0.00784468837082386,
0.02799522504210472,
0.025237418711185455,
-0.006546896882355213,
-0.016477322205901146,
-0.009072955697774887,
-0.02683648280799389,
0.05385836586356163,
-0.0451214425265789,
-0.017612889409065247,
0.019443703815340996,
-0.0075897653587162495,
-0.009640740230679512,
-0.003968694247305393,
0.04268808290362358,
0.01577048934996128,
-0.004574137274175882,
-0.058307938277721405,
0.03209717571735382,
0.0012203010264784098,
-0.00565466471016407,
0.008754301816225052,
0.007375397719442844,
0.007120474241673946,
-0.003650039667263627,
0.06229401379823685,
-0.03561975434422493,
-0.01447269693017006,
0.028041575103998184,
0.01449587196111679,
0.023916451260447502,
-0.0020958760287612677,
-0.0034907127264887094,
-0.02838919870555401,
0.022665008902549744,
-0.0021349836606532335,
-0.008893351070582867,
0.0034965062513947487,
-0.008864382281899452,
0.0189338568598032,
0.011911875568330288,
0.0017569437623023987,
-0.019698627293109894,
0.007682464551180601,
-0.01931624300777912,
-0.036106426268815994,
-0.03529530391097069,
0.016396209597587585,
0.026535209268331528,
-0.02234056033194065,
-0.009148274548351765,
0.003618174232542515,
0.01738114096224308,
-0.034553710371255875,
-0.010417097248136997,
0.017357967793941498,
-0.005263588856905699,
0.024959320202469826,
-0.004779813811182976,
0.015191118232905865,
0.01887591928243637,
0.0007807029760442674,
0.02447264827787876,
0.016581609845161438,
-0.03798358887434006,
-0.01590953767299652,
-0.02882952056825161,
-0.037218816578388214,
-0.02583996392786503,
-0.016118112951517105,
-0.0061471303924918175,
0.01035336684435606,
0.02237532287836075,
0.010845832526683807,
0.005906691309064627,
0.03221305087208748,
-0.028597772121429443,
0.013568878173828125,
0.02114705555140972,
0.031749553978443146,
0.016593197360634804,
-0.007143649272620678,
-0.018771633505821228,
-0.006535309366881847,
-0.00738698523491621,
0.013534115627408028,
0.037126120179891586,
-0.0010435926960781217,
0.01092115044593811,
-0.043870002031326294,
-0.023163268342614174,
0.0013506595278158784,
0.03323274478316307,
-0.06164511665701866,
-0.022444847971200943,
-0.008128580637276173,
-0.01223632413893938,
0.002710009692236781,
0.033418141305446625,
0.01782146468758583,
0.053070418536663055,
0.02200452610850334,
0.01809956133365631,
0.019466878846287727,
0.024240899831056595,
-0.01007526833564043,
-0.0011515006190165877,
-0.018250199034810066,
0.008962875232100487,
-0.011019643396139145,
0.0410194955766201,
-0.022247862070798874,
-0.001982898684218526,
-0.014692858792841434,
0.001882957061752677,
0.02181912586092949,
0.01154687162488699,
0.004999975208193064,
-0.015712551772594452,
0.0035834121517837048,
0.02400914952158928,
-0.017172567546367645,
0.027068231254816055,
-0.0050781904719769955,
-0.010619877837598324,
-0.005315732676535845,
-0.0012688233982771635,
0.0007423196220770478,
-0.019941963255405426,
0.018667345866560936,
0.022050874307751656,
-0.00019608100410550833,
-0.01399761252105236,
0.01412507425993681,
-0.003160470863804221,
-0.027091406285762787,
-0.01599065028131008,
-0.0014288746751844883,
-0.005110055673867464,
-0.01718415506184101,
-0.025932664051651955,
-0.022050874307751656,
0.015805251896381378,
0.007914213463664055,
-0.0013984576798975468,
-0.00981455110013485,
0.02500566840171814,
0.005611211992800236,
-0.014634921215474606,
-0.02339501678943634,
0.03928137943148613,
-0.012421722523868084,
-0.012549184262752533,
-0.04801829904317856,
0.054043762385845184,
-0.013951263390481472,
-0.03392798826098442,
0.0004692908260039985,
0.029617466032505035,
-0.00012121535837650299,
0.0337657630443573,
0.008539934642612934,
-0.018470359966158867,
0.026929182931780815,
0.02195817604660988,
0.021031182259321213,
-0.00922938622534275,
0.020579271018505096,
0.02015053667128086,
-0.02281564474105835,
-0.03460006043314934,
0.005399741232395172,
0.009884076192975044,
-0.01696399413049221,
-0.01873687095940113,
-0.027601253241300583,
0.004015043843537569,
-0.012120449915528297,
0.0198492631316185,
0.022213099524378777,
-0.02544599212706089,
0.0032415830064564943,
-0.0018699211068451405,
-0.009461134672164917,
-0.019339416176080704,
0.028018400073051453,
0.0004993457114323974,
-0.0066164215095341206,
0.0008031536126509309,
0.01895703189074993,
0.010063680820167065,
0.008024293929338455,
-0.016848120838403702,
-0.012039337307214737,
-0.040347423404455185,
-0.009519072249531746,
0.04648876190185547,
0.0006141336634755135,
-0.013719514943659306,
0.03981440141797066,
0.005924072582274675,
-0.004481437616050243,
0.007410160265862942,
0.0001089942452381365,
-0.0043336981907486916,
-0.0005036910297349095,
-0.004116433672606945,
0.019884025678038597,
0.025214243680238724,
-0.027531728148460388,
0.016013825312256813,
0.016315098851919174,
-0.024982495233416557,
-0.010341779328882694,
0.005269382614642382,
-0.009999950416386127,
-0.01031281054019928,
0.032746072858572006,
-0.013800626620650291,
0.008371916599571705,
0.009171449579298496,
0.043058883398771286,
0.0465119369328022,
0.006639596074819565,
-0.0007698397384956479,
0.033140044659376144,
0.013093793764710426,
-0.004041115287691355,
-0.014322061091661453,
-0.0053418041206896305,
-0.0184587724506855,
-0.010052093304693699,
-0.04829639941453934,
-0.007149443030357361,
0.024773919954895973,
-0.02050974778831005,
-0.019026556983590126,
-0.0039020662661641836,
0.026002187281847,
-0.0006264453404583037,
-0.014461110346019268,
-0.012294260784983635,
0.012560771778225899,
0.0053678760305047035,
0.004881204105913639,
-0.004614693112671375,
-0.039489954710006714,
-0.01771717704832554,
0.028018400073051453,
-0.007473891135305166,
0.002954794093966484,
0.021830713376402855,
0.030474934726953506,
0.021969763562083244,
-0.0014201841549947858,
-0.0039918688125908375,
-0.012850457802414894,
0.007641908712685108,
-0.059698428958654404,
0.013267604634165764,
-0.03181907534599304,
-0.006419435143470764,
0.016732245683670044,
-0.023510891944169998,
-0.02910761907696724,
0.0016541053773835301,
-0.0026839380152523518,
-0.002262445166707039,
-0.019397353753447533,
0.010903769172728062,
-0.0016671412158757448,
-0.002172642620280385,
0.0032850357238203287,
0.020996419712901115,
-0.03517943248152733,
0.014762382954359055,
0.0030474935192614794,
0.009872488677501678,
-0.0051129525527358055,
-0.010254873894155025,
-0.04046329855918884,
0.02472757175564766,
0.0008219831506721675,
0.042201410979032516,
-0.012595534324645996,
0.015863189473748207,
-0.016570022329688072,
-0.014391585253179073,
0.03466958552598953,
0.004484334494918585,
0.00007477511826436967,
-0.024912970140576363,
-0.009553833864629269,
-0.0038644070737063885,
-0.0036123807076364756,
0.01442634779959917,
0.03218987584114075,
0.036407697945833206,
-0.04257221147418022,
-0.008418266661465168,
-0.015295404940843582,
0.00021255688625387847,
-0.02458852156996727,
-0.02419454976916313,
0.007247935980558395,
-0.0013774554245173931,
-0.04342968016862869,
-0.0014122177381068468,
0.008458822034299374,
0.015364929102361202,
-0.0035978963132947683,
0.02084578201174736,
-0.02431042306125164,
-0.011118137277662754,
-0.009501690976321697,
-0.01462333370000124,
0.01807638816535473,
0.012340610846877098,
0.02885269559919834,
-0.031170180067420006,
0.016222398728132248,
-0.05056753382086754,
0.03107748180627823,
-0.0005359185161069036,
0.020359110087156296,
-0.02297786995768547,
-0.041923314332962036,
0.009015019051730633,
0.0328155942261219,
0.00043054536217823625,
0.02269977144896984,
0.04069504514336586,
0.002634691307321191,
-0.022386910393834114,
0.029038093984127045,
-0.028458721935749054,
0.00302142184227705,
-0.0047305673360824585,
-0.005895103793591261,
-0.0050202528946101665,
-0.01630351133644581,
-0.003279241966083646,
0.005645974073559046,
-0.024658046662807465,
-0.0069466629065573215,
-0.025955839082598686,
-0.0187136959284544,
-0.019953550770878792,
0.01774035207927227,
-0.019026556983590126,
0.001655553700402379,
-0.010625671595335007,
-0.04778655245900154,
-0.04595573991537094,
0.011065993458032608,
-0.0006883656606078148,
-0.029432065784931183,
-0.008169136941432953,
-0.019663864746689796,
0.0023971491027623415,
0.032722897827625275,
-0.01873687095940113,
0.0005359185161069036,
0.04213188588619232,
0.013302367180585861,
0.013371891342103481,
0.009333672933280468,
0.0004193200438749045,
0.025469167158007622,
-0.018551472574472427,
0.006709120701998472,
-0.02542281709611416,
0.011396234855055809,
0.01718415506184101,
-0.02472757175564766,
0.0312397051602602,
0.04871354624629021,
-0.014287298545241356,
0.023580415174365044,
-0.010370748117566109,
-0.005863238591700792,
0.049547839909791946,
-0.013140142895281315,
-0.016512084752321243,
0.010289635509252548,
0.003771707648411393,
-0.01740431599318981,
-0.017369553446769714,
0.017612889409065247,
-0.006222448777407408,
0.0022074049338698387,
0.029918737709522247,
0.005608315113931894,
-0.024403123185038567,
-0.03309369459748268,
-0.000438873830717057,
0.014020787551999092,
-0.015863189473748207,
0.01724209263920784,
0.01070098951458931,
-0.014240948483347893,
-0.028319673612713814,
-0.0184935349971056,
-0.008308186195790768,
-0.02337184175848961,
0.00688872579485178,
0.01447269693017006,
0.004449572414159775,
0.013244429603219032,
-0.0022204408887773752,
0.007688258308917284,
-0.015005718916654587,
-0.02572409063577652,
-0.02811110019683838,
-0.007960562594234943,
-0.004301832523196936,
-0.009391610510647297,
-0.018980206921696663,
-0.007780957967042923,
0.010724164545536041,
-0.03381211310625076,
0.03731151670217514,
0.006112368311733007,
0.014878257177770138,
-0.007636114954948425,
-0.0004888445837423205,
-0.03353401646018028,
-0.0065642776899039745,
-0.02658155933022499,
0.02050974778831005,
-0.011373060755431652,
-0.01688288152217865,
-0.03239844739437103,
0.005431606899946928,
-0.003838335396721959,
0.01434523519128561,
-0.06544579565525055,
0.002710009692236781,
0.029710164293646812,
0.011981400661170483,
-0.004423500504344702,
0.04016202315688133,
-0.011228217743337154,
0.010828451253473759,
-0.031193355098366737,
-0.025330116972327232,
0.009455340914428234,
0.024542171508073807,
-0.02655838429927826,
-0.02655838429927826,
0.0014947782037779689,
-0.01730003021657467,
0.012143624015152454,
-0.03714929521083832,
-0.006094987038522959,
0.01462333370000124,
-0.031007956713438034,
-0.005834269803017378,
0.0033690447453409433,
0.002078494755551219,
-0.032027650624513626,
0.006170305423438549,
-0.03360354155302048,
0.005431606899946928,
0.01599065028131008,
0.004388738423585892,
0.03191177546977997,
0.03093843162059784,
-0.02672060765326023,
-0.0005681460606865585,
0.0004797919245902449,
0.0071146804839372635,
-0.01308220624923706,
0.010214317589998245,
0.03816898539662361,
-0.005712601821869612,
0.0011819176143035293,
0.017948925495147705,
-0.00038347142981365323,
-0.03448418527841568,
0.00840088538825512,
-0.011552665382623672,
-0.009878282435238361,
0.01682494580745697,
-0.03761279210448265,
0.02145991660654545,
0.015782076865434647,
0.020695146173238754,
0.008678983896970749,
0.03561975434422493,
-0.034136563539505005,
0.026512034237384796,
0.00009333311027148739,
-0.010648846626281738,
0.019038144499063492,
-0.004794298205524683,
-0.02502884343266487,
0.027021881192922592,
-0.003215511329472065,
-0.010150587186217308,
0.03404386341571808,
0.0027129065711051226,
-0.003873097710311413,
0.028922220692038536,
-0.009240973740816116,
-0.002721597207710147,
0.011483141221106052,
-0.004626280628144741,
-0.004165680147707462,
0.016002237796783447,
0.012143624015152454,
0.006222448777407408,
0.01103123091161251,
0.010903769172728062,
-0.018667345866560936,
0.005289660766720772,
-0.027091406285762787,
0.010967500507831573,
-0.022583896294236183,
0.0004019389161840081,
0.10651163756847382,
-0.020868957042694092,
0.012630295939743519,
0.010104237124323845,
-0.00023899070220068097,
-0.023846926167607307,
0.02040546014904976,
0.002014764118939638,
0.05056753382086754,
-0.019524816423654556,
0.024959320202469826,
0.005753158126026392,
0.027091406285762787,
0.0323752723634243,
0.031448278576135635,
-0.014287298545241356,
0.017809877172112465,
0.04259538650512695,
-0.011958225630223751,
0.0017815669998526573,
0.02586313895881176,
0.02023164927959442,
-0.009333672933280468,
0.02447264827787876,
-0.025538690388202667,
0.0009661017684265971,
-0.016199223697185516,
-0.020961657166481018,
0.010214317589998245,
-0.018551472574472427,
0.027925701811909676,
-0.007103093434125185,
0.006297767162322998,
-0.028296498581767082,
0.0027244938537478447,
-0.030359061434864998,
-0.006599040236324072,
-0.019038144499063492,
0.002721597207710147,
0.010926944203674793,
-0.012908394448459148,
0.0003867303894367069,
-0.002372525865212083,
0.035272128880023956,
0.04025472328066826,
0.0076245274394750595,
-0.0350867323577404,
0.004681320860981941,
0.0068249949254095554,
-0.027091406285762787,
0.005617005750536919,
0.0011174625251442194,
0.00037767773028463125,
-0.014287298545241356,
-0.03334861621260643,
0.010086855851113796,
0.011257186532020569,
-0.004901481792330742,
-0.009148274548351765,
-0.02910761907696724,
-0.03147145360708237,
0.03522577881813049,
0.013951263390481472,
-0.007479684427380562,
0.007479684427380562
] | 2024-06-28 | 44 | 38939825 | [
"tumor cells",
"improved tumor antigen selectivity",
"prostate stem cell antigen",
"tumor antigen selectivity",
"solid tumors",
"tumor",
"solid tumor CAR T cell therapies",
"similar CAR T cell clinical responses",
"low antigen density",
"various nonsignaling extracellular spacers",
"CAR",
"CARs",
"Advancing chimeric antigen receptor",
"improved preclinical antitumor activity",
"T cell persistence",
"Similar studies",
"breast cancer brain metastasis",
"a CAR T cell therapy",
"HER2-directed CAR T cells",
"high antigen density",
"the intracellular co-stimulatory domain",
"design considerations",
"selective targeting",
"improved safety",
"overall safety",
"(CAR)-engineered T cells",
"cellular immunotherapy",
"Several hurdles",
"hematological malignancies",
"structure"
] | [
"CAR",
"HER2",
"MT: Regular Issue",
"PSCA",
"T cell immunotherapy",
"breast cancer",
"chimeric antigen receptor",
"nonsignaling extracellular spacer domain",
"prostate cancer"
] | 0 | 10.1016/j.omton.2024.200789 | [
"Kennewick",
"Yamaguchi",
"Gibson",
"Gerdts",
"Jeang",
"Tilakawardane",
"Murad",
"Chang",
"Wright",
"Thiel",
"Forman",
"Stern",
"Priceman"
] | [
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.\nDepartment of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.",
"Department of Chemical, Biological, and Materials Engineering, University of South Florida, Tampa, FL 33620, USA.",
"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.\nDepartment of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA."
] | [
"38939825",
"32916883",
"31629009",
"31167925",
"29312333",
"32215875",
"26898190",
"20179677",
"26330166",
"31848460",
"26330164",
"31110702",
"29308300",
"30918399",
"29061641",
"32193224",
"25366031",
"32397414",
"33833759",
"28180032",
"20483753",
"18453625",
"18354214",
"25212991",
"30666307",
"15838376",
"23620405",
"35935988",
"23243285",
"15695389",
"35738799",
"33837065",
"34155388",
"35418687",
"29808007",
"29808005",
"36658158",
"22706089",
"30348790",
"28683298",
"15980149",
"17483330",
"24395782",
"22330761"
] | [] | 9.24307 | 5.084538 |
38937625 | 797 | 4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20. | CD28 and 4-1BB costimulatory endodomains included in chimeric antigen receptor (CAR) molecules play a critical role in promoting sustained antitumor activity of CAR-T cells. However, the molecular events associated with the ectopic and constitutive display of either CD28 or 4-1BB in CAR-T cells have been only partially explored. In the current study, we demonstrated that 4-1BB incorporated within the CAR leads to cell cluster formation and cell death in the forms of both apoptosis and necroptosis in the absence of CAR tonic signaling. Mechanistic studies illustrate that 4-1BB sequesters A20 to the cell membrane in a TRAF-dependent manner causing A20 functional deficiency that in turn leads to NF-κB hyperactivity, cell aggregation via ICAM-1 overexpression, and cell death including necroptosis via RIPK1/RIPK3/MLKL pathway. Genetic modulations obtained by either overexpressing A20 or releasing A20 from 4-1BB by deleting the TRAF-binding motifs of 4-1BB rescue cell cluster formation and cell death and enhance the antitumor ability of 4-1BB-costimulated CAR-T cells. | [
0.03148466348648071,
-0.012838639318943024,
0.044899243861436844,
0.08178333193063736,
-0.026757163926959038,
-0.017458150163292885,
0.024489404633641243,
-0.022689595818519592,
-0.011728757061064243,
-0.007283227983862162,
0.024393415078520775,
0.017602134495973587,
-0.03129268437623978,
-0.0004600762331392616,
0.015934310853481293,
-0.0507306233048439,
0.020229855552315712,
-0.02620522305369377,
0.008939052931964397,
0.02620522305369377,
-0.007223234511911869,
0.027813052758574486,
-0.001186374225653708,
0.01777011714875698,
-0.04139561206102371,
-0.0006438067648559809,
0.04281146451830864,
-0.038899876177310944,
0.00520744826644659,
-0.04271547496318817,
0.015994304791092873,
-0.02560528740286827,
-0.03026079386472702,
-0.027717063203454018,
-0.04806690663099289,
0.025077342987060547,
0.010186920873820782,
0.024417413398623466,
-0.01708618924021721,
-0.0027882044669240713,
0.03479631245136261,
0.021909678354859352,
0.01399051770567894,
0.06205742433667183,
-0.06162546947598457,
-0.020289849489927292,
-0.021657705307006836,
-0.027717063203454018,
0.04518721252679825,
0.014782433398067951,
-0.00933501124382019,
0.018993986770510674,
-0.02654118835926056,
0.061385493725538254,
-0.053994279354810715,
0.039883773773908615,
0.02666117437183857,
0.011578773148357868,
0.010066932998597622,
0.02050582692027092,
0.008831064216792583,
-0.038443926721811295,
0.012238702736794949,
-0.028748953714966774,
-0.050778619945049286,
-0.03563622385263443,
-0.04235551133751869,
-0.02894093282520771,
0.02336152456700802,
0.01579032652080059,
-0.010666869580745697,
-0.021573713049292564,
0.006371324881911278,
0.015766330063343048,
0.05908174067735672,
0.014962414279580116,
0.017314165830612183,
-0.017134184017777443,
-0.018154075369238853,
0.005009469110518694,
0.0327325314283371,
0.016174286603927612,
-0.007493205834180117,
-0.03738803789019585,
0.014830428175628185,
-0.02486136555671692,
-0.0003194661403540522,
-0.011770752258598804,
-0.04720299690961838,
0.02906092070043087,
0.008297121152281761,
0.01573033258318901,
-0.06992858648300171,
0.020421836525201797,
-0.002447740640491247,
0.025173332542181015,
-0.015334375202655792,
-0.061289504170417786,
0.028916936367750168,
-0.000517820124514401,
0.014326482079923153,
-0.00470650102943182,
-0.031748633831739426,
-0.015286380425095558,
0.02498135343194008,
0.006128350738435984,
-0.06527308374643326,
-0.031532660126686096,
0.035468243062496185,
0.004418531898409128,
0.09819759428501129,
-0.0010041436180472374,
-0.058409810066223145,
0.05562610551714897,
-0.029924828559160233,
-0.032948508858680725,
-0.02546130120754242,
0.024573396891355515,
-0.00941300205886364,
0.012034724466502666,
0.010036936029791832,
0.030092811211943626,
0.03203660622239113,
0.0009111534454859793,
-0.005957368761301041,
-0.00010630123870214447,
0.07851967960596085,
-0.03146066516637802,
-0.036044180393218994,
-0.07002457976341248,
0.06479313224554062,
-0.011050828732550144,
-0.002441741293296218,
-0.014662446454167366,
-0.0471310056746006,
-0.0033986398484557867,
-0.037364039570093155,
0.01100283395498991,
-0.06541706621646881,
0.010696866549551487,
-0.006527308374643326,
0.0031496661249548197,
0.00563040329143405,
0.016810217872262,
-0.023061556741595268,
-0.004577514715492725,
0.004670504946261644,
-0.018454045057296753,
-0.020841792225837708,
0.018322058022022247,
-0.011104823090136051,
0.036068178713321686,
0.06296932697296143,
-0.041083645075559616,
0.021117761731147766,
-0.022137654945254326,
0.00047394976718351245,
0.05212247744202614,
-0.02046983130276203,
-0.045379191637039185,
0.023097552359104156,
-0.004544518422335386,
-0.03014080598950386,
-0.003263654187321663,
-0.020397838205099106,
0.030308788642287254,
0.006701289676129818,
0.014374476857483387,
-0.09032642841339111,
-0.010540883056819439,
-0.0050604636780917645,
-0.04607511684298515,
-0.07064851373434067,
-0.037604015320539474,
-0.07784774899482727,
0.02462139166891575,
-0.008057146333158016,
-0.019317952916026115,
-0.012538671493530273,
0.017062192782759666,
0.0345323421061039,
-0.004136561881750822,
0.05509816110134125,
-0.020349843427538872,
-0.012418683618307114,
0.02290557324886322,
-0.009850956499576569,
0.0318206287920475,
-0.03119669482111931,
-0.013258595019578934,
-0.015514356084167957,
0.024717381224036217,
0.030932722613215446,
0.011734756641089916,
0.027333103120326996,
-0.012634661048650742,
0.00348263094201684,
-0.013690548948943615,
0.006695290561765432,
-0.03434035927057266,
0.040123749524354935,
-0.02918090857565403,
-0.02236562967300415,
0.021273745223879814,
-0.011554775759577751,
0.008981048129498959,
-0.012838639318943024,
0.022989563643932343,
-0.01412250380963087,
-0.00021241499052848667,
0.0390198640525341,
-0.0363321490585804,
0.0014705942012369633,
-0.012214705348014832,
-0.027477087453007698,
-0.024273427203297615,
0.014722439460456371,
0.05212247744202614,
-0.0009216523612849414,
0.021321740001440048,
0.02570127695798874,
-0.031964611262083054,
-0.004382535815238953,
-0.011170816607773304,
-0.03671611100435257,
0.020697806030511856,
0.011068827472627163,
-0.03647613525390625,
0.01846604235470295,
-0.004979472141712904,
0.002500235103070736,
0.04389134794473648,
0.012454680167138577,
0.00504246586933732,
-0.026109233498573303,
-0.02050582692027092,
-0.00560040632262826,
0.026973141357302666,
0.07285627722740173,
-0.027333103120326996,
0.00995294563472271,
-0.010576879605650902,
0.020649811252951622,
-0.021849684417247772,
-0.03381241858005524,
-0.009059039875864983,
-0.010684867389500141,
-0.06407321244478226,
-0.02378148026764393,
-0.005588407628238201,
0.029084917157888412,
0.017974095419049263,
-0.010402897372841835,
0.03062075562775135,
-0.003770600538700819,
0.022293638437986374,
0.05730592831969261,
0.02276158705353737,
-0.007655188906937838,
-0.025509295985102654,
0.0013296090764924884,
0.02230563573539257,
-0.04509122297167778,
-0.020313847810029984,
-0.04703501611948013,
0.007985154166817665,
0.01962991990149021,
0.03578021004796028,
-0.011056828312575817,
-0.007661188021302223,
0.029324892908334732,
-0.0008189132204279304,
0.007259230595082045,
0.029348889365792274,
-0.016102293506264687,
0.017794113606214523,
-0.02410544641315937,
0.03599618375301361,
-0.008501099422574043,
0.01792610064148903,
0.01008493173867464,
-0.013690548948943615,
0.01968991383910179,
-0.03417237848043442,
-0.005213447380810976,
-0.008861061185598373,
-0.0013258594553917646,
-0.00026940894895233214,
-0.007931159809231758,
-0.007409214973449707,
0.03249255567789078,
0.02354150451719761,
-0.01822606846690178,
0.0050604636780917645,
-0.02534131519496441,
-0.025029348209500313,
0.004091566428542137,
-0.036668114364147186,
-0.03206060081720352,
-0.010930841788649559,
-0.044563278555870056,
0.020553821697831154,
-0.07247231900691986,
-0.053034380078315735,
-0.016258276998996735,
0.006827276665717363,
-0.013534565456211567,
-0.011512779630720615,
0.08187932521104813,
0.03801197186112404,
0.026157228276133537,
0.003998576197773218,
-0.02242562361061573,
0.03110070340335369,
-0.024909360334277153,
0.005744391120970249,
0.02500534988939762,
-0.02774105966091156,
0.04050770774483681,
-0.023817475885152817,
-0.040363721549510956,
0.0033956400584429502,
-0.024333421140909195,
-0.0023667491041123867,
0.05197849124670029,
-0.014086507260799408,
0.0010528884595260024,
0.0007754178368486464,
-0.011944734491407871,
-0.009179027751088142,
0.03155665472149849,
-0.026637177914381027,
0.037604015320539474,
0.02822100929915905,
0.014554457738995552,
-0.04007575288414955,
-0.048018909990787506,
-0.04146760702133179,
-0.008717075921595097,
0.016354266554117203,
-0.013882528990507126,
0.04002775996923447,
-0.04379535838961601,
0.02846098318696022,
-0.0074992054142057896,
0.005834381561726332,
-0.016222281381487846,
0.04521121084690094,
-0.011044829152524471,
0.010870847851037979,
0.026757163926959038,
0.015694336965680122,
0.02752508409321308,
-0.007661188021302223,
0.014998410828411579,
0.025869257748126984,
-0.005843380931764841,
-0.021657705307006836,
0.005882376804947853,
0.026397202163934708,
-0.012358690612018108,
0.03208459913730621,
-0.011158817447721958,
0.030788738280534744,
0.021933674812316895,
0.03530025854706764,
-0.03527626022696495,
0.015718333423137665,
-0.00888505857437849,
-0.011800749227404594,
-0.010306907817721367,
0.03136467561125755,
-0.007541201077401638,
-0.015754330903291702,
-0.01729016751050949,
0.011770752258598804,
0.02692514657974243,
0.0021237749606370926,
0.05677798390388489,
-0.04235551133751869,
0.031244689598679543,
-0.022773586213588715,
0.010918842628598213,
-0.025269322097301483,
0.00875307247042656,
0.027357101440429688,
0.031124701723456383,
0.018298061564564705,
-0.07069651037454605,
0.02594125084578991,
0.016042299568653107,
0.008927053771913052,
0.01019291952252388,
-0.010078932158648968,
-0.031052708625793457,
0.04062769562005997,
0.0037136063911020756,
0.037028077989816666,
0.06344927847385406,
0.062249403446912766,
-0.056729987263679504,
-0.0006734286434948444,
-0.021849684417247772,
-0.045835141092538834,
0.01932995207607746,
0.00791316106915474,
0.058889757841825485,
-0.043939344584941864,
0.008153135888278484,
-0.011476784013211727,
-0.005642401985824108,
0.0181660745292902,
0.02486136555671692,
0.009167028591036797,
0.031388673931360245,
-0.026589183136820793,
-0.07031255215406418,
0.01073286309838295,
0.010426894761621952,
0.02666117437183857,
0.03609217703342438,
-0.062009427696466446,
0.02738109789788723,
-0.03405239060521126,
-0.0008264124044217169,
-0.01387052983045578,
0.012454680167138577,
0.0080331489443779,
0.03287651762366295,
-0.059993643313646317,
-0.0020307847298681736,
0.0573539212346077,
0.011038830503821373,
-0.03549223765730858,
-0.001639326335862279,
0.026277216151356697,
-0.03400439769029617,
0.006509310100227594,
-0.07304825633764267,
0.014014515094459057,
-0.05548211932182312,
0.010480889119207859,
-0.01097283698618412,
-0.03695608302950859,
0.007601194549351931,
0.007145242765545845,
0.010768858715891838,
-0.023397520184516907,
-0.009035042487084866,
0.01657024398446083,
-0.03657212480902672,
-0.02774105966091156,
-0.036548126488924026,
0.026877151802182198,
-0.055194150656461716,
-0.014926418662071228,
0.03431636467576027,
-0.02606123872101307,
-0.00490148039534688,
0.0007112995954230428,
0.053994279354810715,
-0.06863272935152054,
0.04977072402834892,
-0.0008031649049371481,
-0.04962674155831337,
0.04792292043566704,
0.018682019785046577,
-0.014662446454167366,
0.02500534988939762,
-0.01750614494085312,
-0.022053662687540054,
0.0005181950982660055,
0.002545230323448777,
0.04806690663099289,
0.019917888566851616,
0.011746754869818687,
0.005525414366275072,
-0.0008421607781201601,
0.03465232625603676,
0.011410790495574474,
-0.0024342420510947704,
-0.001693320577032864,
-0.02512533776462078,
-0.03014080598950386,
0.015982305631041527,
0.06877671182155609,
0.0010903844377025962,
-0.03297250717878342,
-0.029156910255551338,
-0.0000384334271075204,
0.015022408217191696,
-0.004679504316300154,
0.05250643566250801,
-0.01139279268682003,
-0.006179345306009054,
-0.0129826245829463,
0.04905080050230026,
0.00983295775949955,
0.011788750998675823,
-0.00296818558126688,
-0.017518144100904465,
0.05485818535089493,
0.022209646180272102,
-0.025509295985102654,
0.03681210055947304,
0.07583196461200714,
0.003941582515835762,
0.035468243062496185,
-0.030764739960432053,
0.007277228869497776,
-0.017542140558362007,
-0.030764739960432053,
0.017074190080165863,
-0.011914737522602081,
-0.05538612976670265,
-0.03942782059311867,
-0.042259521782398224,
-0.014674444682896137,
-0.019461937248706818,
-0.010708864778280258,
-0.01738615706562996,
-0.03635614737868309,
0.0036896090023219585,
0.021729696542024612,
0.01648625358939171,
-0.009041042067110538,
-0.032348573207855225,
-0.03810796141624451,
-0.02903692238032818,
-0.054570216685533524,
0.016318270936608315,
-0.01804608851671219,
0.017458150163292885,
0.04547518119215965,
-0.009059039875864983,
-0.03244456276297569,
0.01123080961406231,
0.013954521156847477,
-0.01328259240835905,
-0.009496993385255337,
0.0321325957775116,
-0.0114827835932374,
0.033428456634283066,
-0.03254055231809616,
-0.0074992054142057896,
0.004613511264324188,
-0.04425131157040596,
0.00019094851450063288,
0.03083673305809498,
-0.005525414366275072,
0.04017174243927002,
-0.028964931145310402,
0.01900598593056202,
-0.004472526255995035,
0.0033356465864926577,
-0.007649189326912165,
0.006329329218715429,
-0.05951369181275368,
0.0031826626509428024,
-0.02462139166891575,
-0.015874316915869713,
-0.01924595981836319,
-0.0033776420168578625,
-0.02546130120754242,
-0.017842108383774757,
-0.009886952117085457,
-0.01567033864557743,
0.03587619960308075,
-0.021957673132419586,
0.04619510471820831,
-0.005693396553397179,
0.004856485407799482,
-0.004484524950385094,
-0.027165120467543602,
0.01600630395114422,
0.017698124051094055,
-0.023289531469345093,
0.02014586515724659,
-0.00014417222701013088,
-0.021933674812316895,
0.002854197518900037,
0.012454680167138577,
-0.045403189957141876,
0.04161158949136734,
-0.022497616708278656,
0.027189118787646294,
-0.022257640957832336,
-0.019017985090613365,
-0.011602770537137985,
-0.0033056496176868677,
0.012610663659870625,
-0.013774540275335312,
0.030068812891840935,
0.006857273168861866,
-0.016774222254753113,
0.00771518237888813,
-0.0005534413503482938,
-0.009880952537059784,
-0.03143666684627533,
0.05029866844415665,
0.016798220574855804,
-0.01780611276626587,
-0.0447312593460083,
-0.04329141229391098,
-0.02362549677491188,
0.01376254204660654,
0.01357056200504303,
-0.004127562511712313,
-0.010594877414405346,
0.024837367236614227,
0.07410414516925812,
0.01819007284939289,
-0.041683584451675415,
0.009281016886234283,
0.024909360334277153,
0.020877787843346596,
-0.016222281381487846,
-0.03194061666727066,
-0.00010255163215333596,
-0.042643480002880096,
-0.018082084134221077,
0.0055824085138738155,
-0.01956992596387863,
0.007739179767668247,
-0.013174603693187237,
-0.013954521156847477,
-0.01168076228350401,
-0.007541201077401638,
0.025869257748126984,
0.027237113565206528,
-0.004865484312176704,
-0.010126926936209202,
-0.011224810965359211,
0.020277850329875946,
-0.010936841368675232,
-0.05850579962134361,
0.0354202464222908,
-0.00026228470960631967,
-0.0369320847094059,
-0.011662764474749565,
0.014542458578944206,
0.019317952916026115,
0.010240915231406689,
-0.030092811211943626,
0.01717017963528633,
-0.006305331829935312,
-0.008969049900770187,
-0.014842427335679531,
-0.0017458150396123528,
-0.005033466499298811,
-0.002834699582308531,
-0.021573713049292564,
0.00999494083225727,
0.01684621535241604,
0.030476771295070648,
-0.007883165031671524,
0.011944734491407871,
-0.003332646796479821,
0.06968861818313599,
0.04782693088054657,
-0.01855003461241722,
0.035828202962875366,
-0.028868941590189934,
-0.0020502826664596796,
-0.0244654081761837,
0.008597088977694511,
-0.011386793106794357,
0.0033356465864926577,
-0.00878306943923235,
0.02218564972281456,
0.0714644268155098,
-0.0022152652963995934,
0.011938734911382198,
0.011428789235651493,
0.004352538846433163,
0.023769481107592583,
0.003341645933687687,
-0.0036836096551269293,
-0.06378524005413055,
-0.003347645280882716,
-0.0022197647485882044,
0.019437940791249275,
-0.024537399411201477,
-0.07132044434547424,
0.0183100588619709,
0.0006734286434948444,
0.02954087033867836,
0.003938582725822926,
0.01642625965178013,
-0.03465232625603676,
-0.024309424683451653,
-0.01285063847899437,
-0.011242808774113655,
-0.005393428262323141,
-0.015154394321143627,
0.010780857875943184,
-0.00732522364705801,
0.0008819065405987203,
-0.0399317666888237,
-0.009814959950745106,
0.01819007284939289,
0.0026772161945700645,
0.03059675730764866,
-0.042643480002880096,
0.01262266281992197,
-0.053274355828762054,
-0.009311012923717499,
-0.00911303423345089,
-0.005234445445239544,
0.004244550131261349,
0.015382369980216026,
-0.00963497906923294,
-0.012898633256554604,
-0.011044829152524471,
-0.030092811211943626,
0.02486136555671692,
-0.012934628874063492,
0.04209154099225998,
-0.002587225753813982,
0.001497591263614595,
-0.007781175430864096,
0.022917570546269417,
-0.0021522720344364643,
-0.004697502125054598,
0.035084281116724014,
0.0012298696674406528,
-0.012256701476871967,
0.018358055502176285,
-0.01747014932334423,
-0.004403533414006233,
0.01501040905714035,
-0.023049557581543922,
-0.02990083210170269,
-0.007457209751009941,
-0.0333324670791626,
0.02978084422647953,
-0.01804608851671219,
-0.04278746619820595,
0.006695290561765432,
0.02632521092891693,
0.06037760153412819,
0.008279122412204742,
0.0046525071375072,
0.021477723494172096,
-0.004613511264324188,
0.012874635867774487,
-0.00014126628229860216,
-0.05682597681879997,
0.02168170176446438,
-0.03741203621029854,
0.005705395247787237,
0.008747072890400887,
-0.008099141530692577,
-0.006683291867375374,
-0.0035276261623948812,
0.010108929127454758,
0.0072892275638878345,
0.004133562091737986,
-0.004775493871420622,
0.017362160608172417,
-0.016114292666316032,
0.013846532441675663,
0.01597030833363533,
-0.018598029389977455,
-0.013414578512310982,
0.0020802796352654696,
-0.01651025004684925,
0.011350797489285469,
0.005159453488886356,
0.0531303696334362,
-0.027213117107748985,
-0.004757496062666178,
-0.02140573225915432,
-0.018814006820321083,
-0.0072952271439135075,
-0.0014375976752489805,
-0.031124701723456383,
-0.018598029389977455,
-0.012838639318943024,
0.0074752080254256725,
0.014242490753531456,
-0.00312266917899251,
0.003245656145736575,
0.020337844267487526,
-0.030548762530088425,
-0.017482146620750427,
0.00119687314145267,
0.01429048553109169,
-0.048354875296354294,
-0.025149334222078323,
-0.014398474246263504,
0.012670657597482204,
-0.03981178253889084,
0.02008587121963501,
0.0014405973488464952,
0.06229740008711815,
0.02176569402217865,
-0.12257900834083557,
-0.0270211361348629,
-0.016438258811831474,
-0.0006723037804476917,
-0.01738615706562996,
0.004730498883873224,
-0.0017623133026063442,
-0.01669023185968399,
0.0017743119969964027,
-0.0031976611353456974,
-0.014314482919871807,
0.001619828399270773,
0.008099141530692577,
-0.011566773988306522,
-0.001478843274526298,
-0.0035576228983700275,
-0.008645083755254745,
-0.01962991990149021,
0.007559198886156082,
0.0357322134077549,
0.003977578599005938,
0.003001181874424219,
-0.0010791356908157468,
0.04230751842260361,
-0.0007941658259369433,
0.00048482362763024867,
-0.018514038994908333,
-0.0052554430440068245,
-0.026133229956030846,
-0.00401657447218895,
0.01741015538573265,
0.027933040633797646,
-0.020589817315340042,
0.02740509621798992,
-0.011686761863529682,
-0.023613497614860535,
0.015802325680851936,
-0.01579032652080059,
-0.030764739960432053,
0.02798103541135788,
0.008057146333158016,
-0.014026513323187828,
0.015310377813875675,
0.015586348250508308,
-0.01828606240451336,
-0.010726863518357277,
-0.04857085272669792,
-0.027669068425893784,
-0.00917302817106247,
-0.016402261331677437,
0.028388991951942444,
-0.023697488009929657,
-0.03179663047194481,
0.02218564972281456,
-0.000938900513574481,
-0.013294591568410397,
0.002306755632162094,
0.002795703709125519,
0.042283520102500916,
-0.010114927776157856,
-0.00950299296528101,
0.0720403641462326,
0.002695214468985796,
0.01795009709894657,
0.01738615706562996,
-0.02798103541135788,
-0.02510133944451809,
0.0417315773665905,
-0.0399317666888237,
0.0006190593703649938,
-0.004283546004444361,
0.004022573586553335,
-0.055194150656461716,
0.008459103293716908,
-0.02074580080807209,
-0.005750390700995922,
-0.0016498251352459192,
-0.0075531997717916965,
-0.0029156911186873913,
0.011254807002842426,
-0.00186730211135,
-0.04067568853497505,
0.009209023788571358,
0.009736968204379082,
-0.03350045159459114,
-0.019581925123929977,
-0.002660718047991395,
0.029588865116238594,
0.03777199611067772,
-0.010876847431063652,
0.012610663659870625,
0.007067251019179821,
0.0033146487548947334,
-0.02200566790997982,
0.00242374325171113,
0.013042617589235306,
-0.03642813861370087,
0.007985154166817665,
0.00882506463676691,
-0.012022726237773895,
0.05212247744202614,
-0.043099433183670044,
0.002237762790173292,
0.004949475638568401,
-0.03467632457613945,
-0.017434151843190193,
0.021777691319584846,
-0.011542776599526405,
-0.011410790495574474,
-0.011176815256476402,
0.03777199611067772,
-0.009976943023502827,
0.037028077989816666,
0.027189118787646294,
0.00054706702940166,
0.004781493451446295,
0.010780857875943184,
-0.01777011714875698,
-0.01597030833363533,
0.0001955417828867212,
0.028388991951942444,
0.011248808354139328,
-0.020589817315340042,
-0.010852850042283535,
0.014170498587191105,
0.020589817315340042,
0.02104577049612999,
-0.009658976458013058,
0.034028392285108566,
-0.0010671368800103664,
-0.01780611276626587,
-0.009886952117085457,
-0.010396897792816162,
-0.02404545247554779,
0.010990835726261139,
0.025917254388332367,
0.02204166352748871,
0.04374736547470093,
-0.018358055502176285,
0.021573713049292564,
-0.028508979827165604,
-0.022233644500374794,
-0.0006325579597614706,
-0.04252349212765694,
0.027573078870773315,
0.023769481107592583,
-0.04420331493020058,
0.016174286603927612,
-0.015406367368996143,
0.0006269335863180459,
-0.018897997215390205,
0.02824500761926174,
0.007013256661593914,
0.01175275444984436,
0.01244268100708723,
0.050874609500169754,
0.01672622747719288,
-0.04912279546260834,
-0.005234445445239544,
0.03059675730764866,
-0.03208459913730621,
0.052218466997146606,
-0.02366149239242077,
-0.029204905033111572,
0.03849191963672638,
0.008909055963158607,
0.0032996502704918385,
0.00956298690289259,
0.04182756692171097,
0.00457151560112834,
-0.004694502335041761,
-0.06623297929763794,
0.05461821332573891,
-0.011614768765866756,
-0.022533612325787544,
-0.02546130120754242,
0.002114775823429227,
0.011440787464380264,
0.013450575061142445,
0.02254561148583889,
-0.04007575288414955,
-0.013582560233771801,
0.03810796141624451,
0.016618238762021065,
-0.01005493476986885,
0.003977578599005938,
0.014182496815919876,
-0.003971579018980265,
0.013114610686898232,
-0.01184274535626173,
0.006359326187521219,
-0.01651025004684925,
0.017434151843190193,
0.043459393084049225,
0.02726111188530922,
0.00142034946475178,
-0.042763467878103256,
-0.005702395923435688,
-0.050538644194602966,
-0.019809899851679802,
-0.028125019744038582,
0.012970625422894955,
0.04720299690961838,
-0.03681210055947304,
-0.01786610670387745,
-0.0034886302892118692,
-0.0018957990687340498,
-0.024933358654379845,
0.004265548195689917,
0.04362737759947777,
0.0051774512976408005,
0.02632521092891693,
-0.016126291826367378,
0.026469195261597633,
-0.00571139482781291,
0.0015868318732827902,
-0.016642237082123756,
0.007205236237496138,
-0.00807514414191246,
-0.024309424683451653,
-0.043483391404151917,
-0.04149160161614418,
0.022497616708278656,
-0.030644752085208893,
-0.017974095419049263,
-0.026997139677405357,
0.010360902175307274,
-0.004922478459775448,
-0.015610345639288425,
0.027693064883351326,
-0.016498250886797905,
0.02620522305369377,
0.013846532441675663,
0.004613511264324188,
0.0016888210084289312,
-0.00017295042925979942,
-0.052314456552267075,
-0.03479631245136261,
0.008447105064988136,
0.005468420684337616,
0.036068178713321686,
0.0010228916071355343,
-0.015514356084167957,
-0.03083673305809498,
-0.021573713049292564,
-0.01627027615904808,
0.04461127147078514,
0.009263018146157265,
0.004298544488847256,
-0.00493147736415267,
0.004475525580346584,
-0.0022062661591917276,
0.018214069306850433,
0.009383006021380424,
0.042739469558000565,
0.0019227962475270033,
0.03136467561125755,
0.024093447253108025,
0.03822794929146767,
-0.012742649763822556,
-0.00348263094201684,
0.00418155686929822,
-0.011662764474749565,
-0.004700501915067434,
-0.0068992688320577145,
-0.022749589756131172,
-0.0074992054142057896,
-0.015994304791092873,
-0.013906526379287243,
0.018262064084410667,
0.026877151802182198,
0.034244369715452194,
0.012466679327189922,
-0.014638449065387249,
0.0294208824634552,
0.007049253210425377,
0.025677278637886047,
0.009425001218914986,
-0.0270211361348629,
0.0073972162790596485,
0.008225128054618835,
0.007727181073278189,
-0.05322635918855667,
0.01759013533592224,
0.01926995813846588,
0.01627027615904808,
-0.0090830372646451,
0.015454362146556377,
0.011596770957112312,
-0.0016033301362767816,
0.005564410239458084,
-0.0007484207162633538,
0.0014945915900170803,
-0.01067286916077137,
0.006122351158410311,
-0.017842108383774757,
0.010822853073477745,
-0.016654234379529953,
0.005726393312215805,
0.0006925516063347459,
-0.014134502038359642,
0.018298061564564705,
-0.00881306640803814,
-0.041443608701229095,
0.035204268991947174,
-0.01309061236679554,
0.005330435000360012,
-0.03146066516637802,
0.018538035452365875,
-0.0017233174294233322,
-0.022773586213588715,
0.01357056200504303,
-0.0017293167766183615,
-0.012310695834457874,
0.0022152652963995934,
0.014842427335679531,
-0.016738226637244225,
0.014038512483239174,
0.01169276051223278,
-0.02870095893740654,
-0.02300156280398369,
0.019221963360905647,
0.025269322097301483,
-0.005297438707202673,
-0.014374476857483387,
-0.004979472141712904,
0.010906844399869442,
-0.007307225838303566,
0.02408144809305668,
-0.0027087130583822727,
-0.007229234091937542,
-0.014758436009287834,
0.01996588334441185,
0.010150924324989319,
-0.0014960914850234985,
0.02668517269194126,
-0.03129268437623978,
0.00018551159882918,
-0.021789690479636192,
0.03232457488775253,
-0.015454362146556377,
0.03035678341984749,
0.029156910255551338,
-0.011488782241940498,
0.004070568829774857,
-0.009856955148279667,
-0.01900598593056202,
-0.040363721549510956,
-0.03110070340335369,
-0.023277534171938896,
0.0495307520031929,
0.0005845630657859147,
-0.005642401985824108,
0.02014586515724659,
-0.001828306238166988,
-0.025917254388332367,
0.01825006678700447,
0.024789372459053993,
-0.019221963360905647,
0.023073554039001465,
-0.04269147664308548,
0.04146760702133179,
0.05989765375852585,
-0.00571139482781291,
-0.01061287522315979,
0.021273745223879814,
-0.0363321490585804,
0.012184708379209042,
0.00924502033740282,
0.03050076775252819,
-0.018514038994908333,
-0.0020547823514789343,
-0.00064455671235919,
0.008831064216792583,
-0.012394686229526997,
0.0034346359316259623,
0.03786798566579819,
0.007487206719815731,
0.004883482586592436,
0.03071674518287182,
0.03122069127857685,
-0.018658023327589035,
-0.005798385478556156,
-0.027645070105791092,
-0.014374476857483387,
-0.030476771295070648,
-0.04019574075937271,
-0.0214657261967659,
0.015514356084167957,
-0.026397202163934708,
-0.008615086786448956,
-0.002738709794357419,
0.0009981442708522081,
0.03026079386472702,
-0.03206060081720352,
-0.011134820058941841,
0.0020637812558561563,
-0.007349221035838127,
-0.02098577655851841,
0.002270759316161275,
-0.014830428175628185,
-0.01867002248764038,
0.03035678341984749,
-0.005642401985824108,
-0.0023997456301003695,
0.007841168902814388,
0.006509310100227594,
-0.0071632410399615765,
-0.0010678868275135756,
0.018502039834856987,
-0.013750542886555195,
0.008537095040082932,
-0.03254055231809616,
-0.005609405692666769,
-0.012898633256554604,
0.006209341809153557,
0.018874000757932663,
-0.028628965839743614,
0.04038771986961365,
-0.005957368761301041,
-0.00950299296528101,
0.00810514111071825,
-0.0025767269544303417,
0.018694018945097923,
-0.0504426546394825,
-0.0013626056024804711,
0.01393052376806736,
0.006038360297679901,
-0.03587619960308075,
0.03681210055947304,
0.013294591568410397,
-0.020961778238415718,
0.018262064084410667,
-0.028844943270087242,
-0.015058403834700584,
0.015250383876264095,
-0.030908724293112755,
0.013054616749286652,
-0.03539624810218811,
0.02302555926144123,
0.013030619360506535,
0.013138608075678349,
0.04002775996923447,
0.02216165140271187,
0.006317330524325371,
-0.02548529952764511,
0.01936594769358635,
-0.00602036202326417,
0.03203660622239113,
0.01876601204276085,
0.003341645933687687,
0.02128574438393116,
-0.0360201820731163,
0.0002964060986414552,
-0.01783011108636856,
0.005342433694750071,
-0.022053662687540054,
-0.017638130113482475,
0.004715500399470329,
0.025413306429982185,
-0.02344551496207714,
0.006839275360107422,
-0.0072952271439135075,
0.025629283860325813,
-0.008081143721938133,
0.019593924283981323,
-0.003083673305809498,
-0.030884727835655212,
-0.04660306125879288,
0.010426894761621952,
0.0220656618475914,
0.007871165871620178,
0.017734121531248093,
-0.01005493476986885,
0.0369320847094059,
0.00894505251199007,
0.02140573225915432,
-0.0006599300540983677,
0.0027177119627594948,
0.014362477697432041,
-0.02810102142393589,
0.01968991383910179,
0.010666869580745697,
0.01223270408809185,
0.00026772162527777255,
0.023169545456767082,
-0.004220552742481232,
-0.01429048553109169,
0.026253217831254005,
0.013042617589235306,
-0.012754647992551327,
-0.013714546337723732,
-0.01244268100708723,
-0.007817171514034271,
0.019557926803827286,
-0.00869307853281498,
0.006719287950545549,
-0.0052314456552267075,
0.003074674168601632,
-0.014458468183875084,
-0.00027222116477787495,
0.007391216699033976,
0.0046525071375072,
-0.013606558553874493,
0.0028077024035155773,
0.008339116349816322,
-0.01996588334441185,
-0.06109752506017685,
-0.0013011121191084385,
-0.020757799968123436,
0.002695214468985796,
-0.014986411668360233,
-0.009940946474671364,
0.01322259847074747,
0.02966085635125637,
-0.01178275141865015,
-0.0011503781424835324,
0.00846510287374258,
0.0053334347903728485,
0.013894527219235897,
-0.017494145780801773,
0.0019392945105209947,
0.001921296352520585,
-0.012670657597482204,
-0.01867002248764038,
-0.02004987560212612,
0.005120457615703344,
0.0027837050147354603,
-0.04259548708796501,
0.004205554258078337,
0.029468877241015434,
-0.01908997632563114,
0.00999494083225727,
-0.016438258811831474,
-0.012598664499819279,
0.058313820511102676,
0.011254807002842426,
-0.0003832093789242208,
0.003560622688382864,
-0.011296803131699562,
-0.04403533414006233,
0.00624533835798502,
0.050538644194602966,
-0.011086825281381607,
-0.0026202222798019648,
0.030932722613215446,
0.0175661388784647,
-0.04785092920064926,
-0.0034796311520040035,
0.02450140379369259,
0.026493191719055176,
-0.015898315235972404,
0.006833275780081749,
0.022257640957832336,
-0.004058570135384798,
-0.0354202464222908,
0.0037616014014929533,
0.007997152395546436,
-0.027093129232525826,
0.002209265949204564,
0.010636872611939907,
0.015106399543583393,
0.016714228317141533,
0.008939052931964397,
-0.009778963401913643,
0.020361842587590218,
-0.01867002248764038,
-0.010096929967403412,
-0.026973141357302666,
0.005657400470227003,
-0.013642554171383381,
-0.006719287950545549,
0.0005811884184367955,
-0.012694654986262321,
0.010948839597404003,
0.028149016201496124,
-0.00015495232946705073,
0.0054894182831048965,
0.022317634895443916,
0.012118715792894363,
-0.02276158705353737,
0.013018620200455189,
-0.015706336125731468,
0.029468877241015434,
-0.007967155426740646,
-0.04031572863459587,
-0.01573033258318901,
0.03590019419789314,
-0.026613179594278336,
0.005843380931764841,
-0.0372200571000576,
-0.0038005972746759653,
0.01292263064533472,
-0.009017044678330421,
-0.00768518541008234,
0.02846098318696022,
-0.019773904234170914,
-0.030404778197407722,
-0.011728757061064243,
0.0006100603495724499,
-0.014014515094459057,
-0.001702319597825408,
0.013798537664115429,
0.0005954368971288204,
0.0019122973317280412,
-0.025317316874861717,
0.01582632213830948,
-0.02776505798101425,
0.0034886302892118692,
0.003755602054297924,
-0.024453409016132355,
0.0027447091415524483,
-0.01798609457910061,
0.005996364634484053,
0.003836593357846141,
0.03470032289624214,
-0.03966779634356499,
-0.024297425523400307,
0.0013993517495691776,
-0.002836199477314949,
0.017362160608172417,
0.05586608126759529,
-0.045619167387485504,
0.014542458578944206,
0.003599618561565876,
-0.025317316874861717,
0.014086507260799408,
0.015622344799339771,
0.025413306429982185,
-0.02452540025115013,
0.009886952117085457,
0.026349207386374474,
-0.005627403501421213,
-0.023913465440273285,
0.01543036475777626,
-0.027237113565206528,
-0.014698442071676254,
0.004331540782004595,
-0.020301848649978638,
-0.013438575901091099,
-0.012778646312654018,
-0.004577514715492725,
-0.014506462961435318,
0.02350550889968872,
-0.004136561881750822,
0.004970473237335682,
-0.02462139166891575,
0.009269017726182938,
0.035708215087652206,
-0.015106399543583393,
0.007559198886156082,
0.018058085814118385,
-0.010162923485040665,
0.012478677555918694,
0.021297743543982506,
0.00222876388579607,
-0.006137349642813206,
0.019401943311095238,
0.007559198886156082,
-0.0132106002420187,
0.009347009472548962,
-0.014002515934407711,
-0.0029201905708760023,
0.014098506420850754,
0.024189436808228493,
-0.028053026646375656,
0.03887588158249855,
0.014470466412603855,
-0.019701912999153137,
-0.013594559393823147,
-0.05452222377061844,
-0.0004285795730538666,
-0.01573033258318901,
0.002252761274576187,
0.11566774547100067,
-0.03386041149497032,
-0.007985154166817665,
0.026517190039157867,
0.00624533835798502,
-0.020361842587590218,
-0.004556517116725445,
-0.01002493780106306,
0.0004713250673376024,
-0.04422731325030327,
-0.0026352207642048597,
0.008321118541061878,
0.008615086786448956,
-0.004556517116725445,
0.008009151555597782,
0.006761283613741398,
-0.01828606240451336,
0.02258160710334778,
-0.020709805190563202,
-0.0017203177558258176,
0.0032966507133096457,
0.011302802711725235,
-0.025269322097301483,
0.025437304750084877,
-0.017062192782759666,
-0.038683902472257614,
-0.01792610064148903,
-0.033668432384729385,
-0.012742649763822556,
-0.0117107592523098,
0.019161969423294067,
-0.007823171094059944,
0.013294591568410397,
-0.03506028652191162,
0.010366901755332947,
-0.013462573289871216,
-0.02632521092891693,
-0.012766647152602673,
0.018322058022022247,
-0.0009276517084799707,
0.044779255986213684,
0.0008376612095162272,
0.014422471635043621,
0.016378264874219894,
0.019341951236128807,
0.03719605877995491,
-0.01529837865382433,
-0.02678116224706173,
0.025749271735548973,
-0.012466679327189922,
-0.026493191719055176,
0.013582560233771801,
0.02040983736515045,
0.011026831343770027,
-0.010402897372841835,
-0.00963497906923294,
0.03518027067184448,
-0.008927053771913052,
-0.023397520184516907,
-0.03071674518287182,
-0.04350738972425461,
-0.001556835020892322,
0.00866308156400919,
0.03861190751194954,
0.025917254388332367
] | 2024-06-28 | 67 | 38937625 | [
"cell death",
"cell cluster formation",
"cell aggregation",
"A20 functional deficiency",
"A20",
"CAR tonic",
"CAR",
"CAR-T cells",
"sustained antitumor activity",
"constitutive display",
"necroptosis",
"Mechanistic studies",
"the cell membrane",
"CD28",
"ICAM-1 overexpression",
"Genetic modulations",
"TRAF",
"turn",
"4-1BB rescue cell cluster formation",
"chimeric antigen receptor (CAR) molecules",
"NF-κB hyperactivity",
"the CAR",
"4-1BB-costimulated CAR-T cells",
"a critical role",
"RIPK1/RIPK3/MLKL pathway",
"RIPK1/RIPK3",
"the current study",
"NF-κB",
"the antitumor ability",
"a TRAF-dependent manner"
] | [
"4-1BB",
"A20",
"Chimeric antigen receptor (CAR)-T cell",
"NF-κB",
"Necroptosis",
"TNF receptor associated factor (TRAF)"
] | 0 | 10.1038/s41423-024-01198-y | [
"Dou",
"Bonacci",
"Shou",
"Landoni",
"Woodcock",
"Sun",
"Savoldo",
"Herring",
"Emanuele",
"Song",
"Baldwin",
"Wan",
"Dotti",
"Zhou"
] | [
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.\nDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.",
"Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.\nDivision of Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.\nDepartment of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.",
"Michael Hooker Proteomics Center, Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.",
"Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.\nDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.\nDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. [email protected].\nDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA. [email protected].",
"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. [email protected].\nDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA. [email protected]."
] | [
"38937625",
"25317870",
"25154820",
"31042825",
"32701411",
"23515080",
"31900459",
"33824268",
"32004441",
"26461090",
"30131370",
"26885860",
"28978471",
"25939063",
"36882513",
"33547226",
"30753824",
"30617136",
"34897277",
"34381029",
"7622868",
"24732136",
"30788651",
"22195746",
"12752672",
"10614768",
"32778143",
"9346241",
"33203937",
"31243359",
"9464265",
"16200195",
"32669658",
"30232281",
"22343828",
"19494296",
"35099607",
"18952128",
"37031274",
"12869584",
"19239902",
"32758419",
"26649818",
"25242415",
"19008218",
"30042418",
"35611809",
"28406481",
"38012417",
"28193872",
"34815265",
"35757562",
"21402742",
"23474202",
"15905862",
"30737145",
"32234960",
"33246882",
"19887045",
"26666474",
"31534131",
"28782755",
"25939025",
"19259067",
"24782509",
"27270177",
"28187946"
] | [] | 7.828715 | 5.341465 |
38936505 | 798 | Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination. | Immunogenic cell death (ICD) is a stress-driven form of regulated cell death (RCD) in which dying tumor cells' specific signaling pathways are activated to release damage-associated molecular patterns (DAMPs), leading to the robust anti-tumor immune response as well as a reversal of the tumor immune microenvironment from "cold" to "hot". Chimeric antigen receptor (CAR)-T cell therapy, as a landmark in anti-tumor immunotherapy, plays a formidable role in hematologic malignancies but falls short in solid tumors. The Gordian knot of CAR-T cells for solid tumors includes but is not limited to, tumor antigen heterogeneity or absence, physical and immune barriers of tumors. The combination of ICD induction therapy and CAR-T cell immunotherapy is expected to promote the intensive use of CAR-T cell in solid tumors. In this review, we summarize the characteristics of ICD, stress-responsive mechanism, and the synergistic effect of various ICD-based therapies with CAR-T cells to effectively improve anti-tumor capacity. | [
0.024576812982559204,
0.01450631394982338,
0.022982317954301834,
0.056778434664011,
-0.013954834081232548,
-0.019733382388949394,
0.02346186526119709,
0.023965390399098396,
0.005751573946326971,
0.0008826672565191984,
0.0064678979106247425,
0.00487939640879631,
-0.040186088532209396,
-0.011832836084067822,
0.022982317954301834,
-0.048170555382966995,
0.03141036629676819,
0.018270762637257576,
-0.003455739701166749,
0.037668462842702866,
-0.017539452761411667,
0.0009448585915379226,
-0.007894552312791348,
0.008218246512115002,
-0.02436101622879505,
-0.012684033252298832,
0.023114193230867386,
0.0404498390853405,
0.029396265745162964,
-0.03388003632426262,
0.04116915911436081,
-0.016688255593180656,
-0.03709300607442856,
-0.06262890994548798,
0.007666767109185457,
0.04112120345234871,
0.0044088405556976795,
0.04284757748246193,
-0.00972882192581892,
-0.02360573038458824,
0.013810969889163971,
-0.01704791560769081,
0.02191532403230667,
0.09586156159639359,
-0.07994057983160019,
-0.017263712361454964,
-0.01135928276926279,
-0.0406656339764595,
0.03399992361664772,
-0.007918529212474823,
-0.02925240248441696,
0.037620507180690765,
0.018019000068306923,
0.048386350274086,
-0.07001394778490067,
0.04428621754050255,
-0.016040867194533348,
0.024816587567329407,
-0.000517012202180922,
0.013954834081232548,
0.025320112705230713,
-0.03575027361512184,
0.0242291409522295,
-0.036853231489658356,
-0.037596531212329865,
0.01370307244360447,
-0.05198295786976814,
-0.013127614744007587,
0.006282073445618153,
0.01373903825879097,
0.025248179212212563,
-0.03296889737248421,
-0.009393137879669666,
-0.011203430593013763,
0.03905915096402168,
-0.0057335905730724335,
-0.0322495736181736,
0.02340192161500454,
-0.0013472290011122823,
-0.006509858183562756,
0.057785481214523315,
-0.01095166802406311,
0.01950559765100479,
-0.05591524764895439,
-0.026039432734251022,
-0.004055174067616463,
-0.02276652120053768,
-0.05965571850538254,
-0.028748877346515656,
-0.0052210744470357895,
-0.01538148894906044,
0.03632573038339615,
-0.030475247651338577,
0.018966106697916985,
-0.018834231421351433,
-0.009507030248641968,
0.030954796820878983,
-0.03129047900438309,
0.004618642386049032,
0.008601884357631207,
0.02014099806547165,
-0.01541745476424694,
-0.013930857181549072,
-0.009321206249296665,
0.030259452760219574,
-0.010370216332376003,
-0.07874171435832977,
-0.024001356214284897,
0.02264663390815258,
0.0003635944740381092,
0.07596033811569214,
-0.010807803831994534,
-0.04627634212374687,
0.0731789618730545,
-0.0321057103574276,
-0.06047094985842705,
-0.012767953798174858,
0.01249221432954073,
-0.0053709326311945915,
-0.0017383599188178778,
-0.0020890291780233383,
0.013547219336032867,
0.014422393403947353,
-0.030906841158866882,
-0.005083204247057438,
-0.029324334114789963,
0.06133413687348366,
-0.049824994057416916,
-0.031889915466308594,
-0.05164727568626404,
-0.017371611669659615,
0.005988350138068199,
0.020608557388186455,
-0.030331384390592575,
-0.03148229792714119,
-0.011437209323048592,
-0.004558699205517769,
0.0031530254054814577,
-0.024720678105950356,
-0.014290518127381802,
0.005334966816008091,
-0.020608557388186455,
0.006045296788215637,
-0.0005717106396332383,
-0.021459754556417465,
-0.04598861187696457,
0.007936512120068073,
0.020512647926807404,
-0.004273967817425728,
0.013595174066722393,
-0.04776293784379959,
0.055339790880680084,
0.07960490137338638,
-0.012743976898491383,
-0.0037524597719311714,
-0.028557058423757553,
-0.0160528551787138,
0.05322978273034096,
-0.016820130869746208,
-0.045700885355472565,
-0.011748915538191795,
-0.006359999533742666,
0.002051564399152994,
-0.01688007451593876,
-0.011077549308538437,
0.00014021147217135876,
-0.0005177615093998611,
0.03903517127037048,
-0.046588048338890076,
0.011395249515771866,
-0.03634970635175705,
-0.06699279695749283,
-0.0732748731970787,
-0.015405465848743916,
-0.049872949719429016,
-0.007271140348166227,
0.005391913000494242,
0.049009762704372406,
-0.019577529281377792,
0.006575796287506819,
-0.00932720024138689,
0.01539347693324089,
-0.010400188155472279,
-0.0029342316556721926,
-0.007061338052153587,
0.003027144121006131,
0.0032729122322052717,
0.04347098618745804,
-0.05279818922281265,
-0.008356116712093353,
0.001171894371509552,
0.00042185201891697943,
0.042320072650909424,
0.011838831007480621,
0.006623751018196344,
-0.008787709288299084,
0.005937398411333561,
0.002757398644462228,
-0.0037854285910725594,
0.000663124374113977,
0.02913251519203186,
-0.03404787927865982,
-0.029492175206542015,
-0.013187558390200138,
-0.0241572093218565,
-0.0052510458044707775,
-0.05581933632493019,
0.06354005634784698,
-0.008973534218966961,
0.032777078449726105,
0.02740614488720894,
-0.021543674170970917,
0.0007575353374704719,
0.008505974896252155,
0.00668968865647912,
-0.0324174165725708,
0.037500619888305664,
0.03718891367316246,
0.031985823065042496,
0.01703592762351036,
0.016628311946988106,
0.01699996180832386,
-0.042511891573667526,
-0.007660772651433945,
-0.04450201615691185,
0.016820130869746208,
0.00970484409481287,
-0.02090827375650406,
0.01456625759601593,
-0.002544599352404475,
-0.02338993363082409,
-0.012072610668838024,
0.012204485945403576,
-0.015525353141129017,
-0.04373474046587944,
-0.0021759471856057644,
-0.01539347693324089,
-0.018007012084126472,
0.065170519053936,
-0.006989405956119299,
0.013822958804666996,
0.024912497028708458,
0.021303901448845863,
-0.03579822555184364,
-0.06075867637991905,
0.010184391401708126,
0.006204146891832352,
-0.046468161046504974,
-0.004984297789633274,
-0.026447048410773277,
0.0016469461843371391,
0.0014955890364944935,
0.005955381318926811,
-0.004690574947744608,
0.011035588569939137,
-0.008679810911417007,
0.07006189972162247,
-0.059367988258600235,
-0.0009875682881101966,
-0.016316605731844902,
0.011635023169219494,
0.02661489136517048,
-0.008667821995913982,
-0.038411762565374374,
-0.07034962624311447,
0.0101364366710186,
-0.015861036255955696,
-0.027046483010053635,
0.0003866352199111134,
0.007031366229057312,
0.004297945182770491,
0.0001038707559928298,
0.03404787927865982,
0.003989236429333687,
-0.013235513120889664,
0.026902619749307632,
-0.01785115897655487,
0.041672684252262115,
-0.011119509115815163,
0.02977990359067917,
-0.023761581629514694,
0.000869929266627878,
0.002893769880756736,
-0.024672722443938255,
-0.02093225158751011,
0.008547935634851456,
-0.02982785925269127,
-0.0025221204850822687,
-0.02759796380996704,
-0.051359545439481735,
0.01047211978584528,
-0.005874457769095898,
-0.04294348508119583,
-0.015717171132564545,
-0.026495004072785378,
0.009261262603104115,
-0.03141036629676819,
0.007223185151815414,
-0.048817943781614304,
0.031961847096681595,
-0.02100418321788311,
0.011527124792337418,
-0.058552760630846024,
-0.042487915605306625,
0.007984466850757599,
0.0010407681111246347,
-0.013882902450859547,
-0.043279167264699936,
0.06047094985842705,
0.008272195234894753,
0.04781089350581169,
-0.017347633838653564,
0.031122637912631035,
0.04677986726164818,
0.019109971821308136,
0.02666284516453743,
0.017203768715262413,
-0.02745409868657589,
0.02089628577232361,
-0.034455493092536926,
-0.016352571547031403,
-0.013906879350543022,
-0.025272157043218613,
0.000019516743122949265,
0.013894891366362572,
-0.023186124861240387,
0.00021991752146277577,
0.004756512586027384,
0.033544354140758514,
-0.03634970635175705,
-0.005973364692181349,
-0.006126220338046551,
0.051311589777469635,
0.002728925319388509,
0.018330706283450127,
-0.026207275688648224,
-0.023162147030234337,
-0.04692373052239418,
0.008523957803845406,
0.02195128984749317,
-0.004489764105528593,
0.05999140068888664,
-0.028772855177521706,
0.03857960179448128,
0.016832120716571808,
-0.0033058810513466597,
-0.02436101622879505,
0.01847456954419613,
0.010520074516534805,
-0.0013082657242193818,
0.008727765642106533,
-0.0014895946951583028,
0.020584579557180405,
-0.00923129078000784,
-0.002772384323179722,
0.03452742472290993,
-0.02029685117304325,
-0.02360573038458824,
0.011083543300628662,
-0.015908990055322647,
0.003851366462185979,
-0.025320112705230713,
0.01294778473675251,
0.05802525579929352,
0.025511931627988815,
0.03728482499718666,
-0.048050668090581894,
0.002964203478768468,
-0.0321296863257885,
-0.04788282513618469,
-0.03409583121538162,
0.028868764638900757,
-0.002947719069197774,
0.004100131802260876,
-0.012126559391617775,
0.05351750925183296,
0.015968933701515198,
0.0241092536598444,
0.04390257969498634,
0.018450593575835228,
0.06224527582526207,
0.005062223877757788,
0.022095154970884323,
0.015165692195296288,
0.019205881282687187,
0.046564068645238876,
0.03610993176698685,
-0.016556380316615105,
-0.06943848729133606,
0.03687720745801926,
0.024600790813565254,
-0.055291835218667984,
-0.005520791281014681,
0.008697793819010258,
-0.047355324029922485,
0.06675302237272263,
-0.05802525579929352,
0.05414092168211937,
0.04459792375564575,
-0.009219301864504814,
-0.01699996180832386,
-0.012288406491279602,
-0.03169809654355049,
-0.040881432592868805,
0.030163543298840523,
-0.007636795286089182,
0.07739897817373276,
-0.02017696388065815,
0.008428048342466354,
-0.030930818989872932,
-0.0161247868090868,
-0.001681413734331727,
0.029660018160939217,
0.010711894370615482,
-0.011587068438529968,
-0.07375441491603851,
-0.03416776657104492,
0.01684410870075226,
0.006473892368376255,
0.0321536660194397,
-0.0007777662249282002,
-0.018222808837890625,
-0.001655937754549086,
-0.06814371049404144,
-0.00847600307315588,
0.023809537291526794,
0.03910710662603378,
0.0026854663155972958,
0.04469383507966995,
-0.05438069626688957,
0.0078046368435025215,
0.08181081712245941,
-0.0011966211022809148,
0.00585947185754776,
-0.02169952727854252,
0.03790823742747307,
-0.017407577484846115,
0.0033927990589290857,
-0.024912497028708458,
0.014698132872581482,
-0.043087348341941833,
0.023749593645334244,
0.029731949791312218,
-0.01928980089724064,
0.022143108770251274,
0.016340583562850952,
0.020656511187553406,
0.002456182846799493,
-0.0031320450361818075,
-0.003206974361091852,
0.004196041263639927,
-0.025487953796982765,
-0.01166499499231577,
-0.018834231421351433,
-0.04136097803711891,
-0.019649462774395943,
0.006809575483202934,
-0.04634827375411987,
-0.02343788743019104,
-0.009177342057228088,
0.027262279763817787,
-0.06847939640283585,
0.042392004281282425,
-0.059463899582624435,
-0.023294024169445038,
0.04596463590860367,
0.024792609736323357,
0.018186841160058975,
-0.0015989914536476135,
-0.015597284771502018,
-0.00966288335621357,
-0.03292094171047211,
0.013031705282628536,
0.032585259526968,
0.029612062498927116,
0.016556380316615105,
0.03910710662603378,
-0.005715607665479183,
0.0007283128798007965,
0.009716833010315895,
0.005065221339464188,
-0.009003506042063236,
-0.052222732454538345,
-0.024013344198465347,
0.049824994057416916,
0.0101004708558321,
-0.06066276878118515,
-0.03073900006711483,
-0.0018492552917450666,
0.059463899582624435,
-0.015093759633600712,
-0.015213646925985813,
0.02910853736102581,
-0.010627972893416882,
-0.01711984910070896,
-0.008182280696928501,
0.018378660082817078,
0.014062732458114624,
-0.011197435669600964,
-0.005688633304089308,
0.024864541366696358,
0.04179257154464722,
-0.004019208252429962,
-0.00894955638796091,
0.04687577486038208,
0.02355777472257614,
0.013463297858834267,
0.07341873645782471,
-0.003290895139798522,
-0.012264429591596127,
-0.0028278320096433163,
-0.009620923548936844,
0.018042977899312973,
-0.017551440745592117,
-0.039203014224767685,
-0.049729082733392715,
-0.039203014224767685,
0.0026944580022245646,
-0.0075948345474898815,
-0.006306050810962915,
-0.032033778727054596,
-0.005194099619984627,
-0.024792609736323357,
0.016556380316615105,
-0.00014171005750540644,
-0.025320112705230713,
-0.022850442677736282,
0.0026105372235178947,
-0.03615788742899895,
-0.018234796822071075,
0.008655834011733532,
-0.013331422582268715,
0.015057793818414211,
0.02172350510954857,
-0.005409895908087492,
-0.006354005541652441,
-0.033520374447107315,
0.023174136877059937,
0.009141375310719013,
-0.049009762704372406,
0.026447048410773277,
-0.004957322962582111,
0.032753098756074905,
-0.010406182147562504,
0.009357172064483166,
0.0323934406042099,
-0.03905915096402168,
-0.0202369075268507,
0.02663886733353138,
0.001180885941721499,
0.010723882354795933,
-0.027957623824477196,
0.019829291850328445,
-0.008206257596611977,
0.013187558390200138,
0.012144542299211025,
-0.005520791281014681,
-0.05231864005327225,
-0.015477398410439491,
-0.011065560393035412,
-0.048194531351327896,
-0.021555664017796516,
-0.0036355701740831137,
-0.020716454833745956,
-0.0036595475394278765,
0.01769530586898327,
0.00731310062110424,
0.02186737023293972,
-0.056059110909700394,
0.04143290966749191,
-0.01942167617380619,
-0.012276417575776577,
-0.01298375055193901,
-0.012851875275373459,
0.02925240248441696,
0.01948161981999874,
-0.03174604848027229,
-0.011916757561266422,
0.009147370234131813,
0.006123223342001438,
-0.025607841089367867,
-0.012636078521609306,
-0.002186437137424946,
0.03632573038339615,
-0.032633211463689804,
0.05183909460902214,
-0.0203208290040493,
-0.01051408052444458,
-0.015585295855998993,
-0.0080683883279562,
0.017167802900075912,
0.0041990382596850395,
0.034311629831790924,
0.013367388397455215,
-0.025679772719740868,
0.0018567482475191355,
0.024528859183192253,
-0.018930140882730484,
-0.010681922547519207,
0.00926725659519434,
-0.011533118784427643,
-0.010088481940329075,
-0.014458359219133854,
-0.04100131615996361,
-0.022826464846730232,
0.03704505041241646,
-0.008368105627596378,
-0.006114231422543526,
-0.0007890056003816426,
0.01460222341120243,
0.02745409868657589,
0.019697416573762894,
-0.013990800827741623,
0.012755965813994408,
0.03721289336681366,
-0.008727765642106533,
-0.027837736532092094,
-0.008511969819664955,
-0.00427996227517724,
-0.02090827375650406,
-0.02817342057824135,
-0.004609650932252407,
0.01499785017222166,
-0.023150159046053886,
-0.010987633839249611,
-0.023905446752905846,
-0.013966822996735573,
-0.01261210162192583,
-0.012456248514354229,
0.0064678979106247425,
-0.00008560673450119793,
0.0055807349272072315,
-0.013786992989480495,
0.015249612741172314,
0.00974080990999937,
-0.03661345690488815,
0.01456625759601593,
-0.019697416573762894,
-0.012348350137472153,
-0.0007556620985269547,
-0.03001967817544937,
0.00482544768601656,
-0.011353288777172565,
-0.017995022237300873,
0.023629706352949142,
-0.008973534218966961,
-0.002214910462498665,
-0.02901262789964676,
0.007738699205219746,
0.0021145050413906574,
0.000027981413950328715,
-0.026518981903791428,
0.00463662575930357,
-0.003671536222100258,
0.02512829378247261,
-0.0050682183355093,
0.029420243576169014,
-0.014889951795339584,
0.007079320959746838,
0.056155022233724594,
-0.0161607526242733,
-0.020752420648932457,
-0.0077626765705645084,
0.010586013086140156,
-0.018210818991065025,
0.026183297857642174,
0.04548508673906326,
-0.011467181146144867,
0.007582846097648144,
-0.0006672454765066504,
0.04517338052392006,
0.005260037258267403,
0.022035211324691772,
-0.019781338050961494,
0.012684033252298832,
0.029731949791312218,
0.010034533217549324,
-0.003980244975537062,
-0.03961062803864479,
-0.019889235496520996,
-0.01950559765100479,
0.01853451319038868,
-0.019133947789669037,
-0.04363882914185524,
-0.008416060358285904,
0.017455531284213066,
0.06934257596731186,
0.003653553081676364,
-0.003386804834008217,
-0.011940734460949898,
0.015501375310122967,
-0.022023223340511322,
-0.021555664017796516,
-0.0035486521665006876,
-0.01340335514396429,
0.024624768644571304,
0.010717888362705708,
-0.011239396408200264,
-0.02596750110387802,
-0.029324334114789963,
0.011173458769917488,
-0.0011209424119442701,
0.013115625828504562,
-0.025296134874224663,
0.04339905455708504,
-0.005272026173770428,
0.018366672098636627,
-0.007097304333001375,
0.02344987727701664,
0.00930921733379364,
0.023593740537762642,
-0.004807464312762022,
-0.02089628577232361,
0.01691604033112526,
-0.021303901448845863,
0.0041990382596850395,
0.0010137935169041157,
0.04186450317502022,
0.0025880583561956882,
-0.0024352024774998426,
0.018126897513866425,
-0.0007095805485732853,
-0.044046446681022644,
-0.025248179212212563,
0.05423682928085327,
0.04781089350581169,
-0.045772816985845566,
0.020644523203372955,
-0.03860358148813248,
-0.009105409495532513,
-0.003908312879502773,
-0.028892740607261658,
-0.04661202430725098,
-0.02656693570315838,
-0.02428908459842205,
0.018930140882730484,
-0.03085888735949993,
-0.0322975292801857,
0.012648067437112331,
0.014218585565686226,
0.0052090855315327644,
-0.009914645925164223,
-0.017635362222790718,
-0.022215042263269424,
0.012660056352615356,
0.008242224343121052,
0.0005593472742475569,
-0.0008504476281814277,
0.017455531284213066,
-0.03311276063323021,
0.041624728590250015,
0.008817681111395359,
-0.044885654002428055,
-0.01292380690574646,
0.028772855177521706,
-0.002421715296804905,
0.018246784806251526,
0.010903713293373585,
-0.020404748618602753,
-0.019925201311707497,
-0.027645917609333992,
-0.0004960320075042546,
0.009063448756933212,
0.024480903521180153,
-0.002799358917400241,
-0.01008248794823885,
-0.010340244509279728,
0.020476682111620903,
0.001801300561055541,
0.029348311945796013,
0.009009500034153461,
0.001861243974417448,
0.00293123465962708,
-0.004028199706226587,
0.015477398410439491,
0.014913929626345634,
-0.051407501101493835,
-0.019014060497283936,
-0.01852252520620823,
0.010915701277554035,
0.015753138810396194,
-0.021519698202610016,
-0.009884674102067947,
0.02752603031694889,
0.009974589571356773,
-0.00008537257963325828,
0.0031590196304023266,
0.017539452761411667,
0.005092195700854063,
-0.024720678105950356,
-0.03172207251191139,
0.04136097803711891,
-0.020884297788143158,
0.04586872458457947,
-0.00893157348036766,
0.03543856739997864,
0.03141036629676819,
-0.09298427402973175,
-0.0202369075268507,
-0.03687720745801926,
-0.003194985678419471,
-0.019721394404768944,
0.00008822925883578137,
0.009015494026243687,
-0.010052516125142574,
0.02330601215362549,
-0.036853231489658356,
-0.0081043541431427,
0.012731987982988358,
0.015513364225625992,
-0.012228462845087051,
0.007924524135887623,
-0.022394871339201927,
-0.000569088093470782,
-0.05246250331401825,
-0.02258669026196003,
0.0282693300396204,
-0.004780489951372147,
-0.021519698202610016,
-0.006054288242012262,
0.05577138438820839,
-0.0076847500167787075,
0.015597284771502018,
-0.023809537291526794,
-0.029300356283783913,
-0.028676945716142654,
-0.029420243576169014,
0.0067076715640723705,
0.0008182280580513179,
-0.015980923548340797,
0.02500840649008751,
0.011587068438529968,
-0.03301684930920601,
0.0322255976498127,
0.0017548444448038936,
-0.015837058424949646,
0.007283128798007965,
0.027190348133444786,
-0.019721394404768944,
0.04100131615996361,
0.019181903451681137,
-0.039274945855140686,
-0.008182280696928501,
-0.03563038632273674,
-0.0016754193929955363,
0.008583901450037956,
0.0009163854410871863,
-0.005919415503740311,
-0.010034533217549324,
-0.03560640662908554,
-0.007612817920744419,
0.0023587746545672417,
0.0071572475135326385,
-0.006923468317836523,
0.05260637030005455,
0.004582676570862532,
-0.004666597582399845,
-0.006923468317836523,
0.03738073259592056,
0.014074721373617649,
0.008188274689018726,
-0.001904702978208661,
-0.0051641277968883514,
-0.009932628832757473,
-0.0020111026242375374,
-0.025655794888734818,
0.00039075635140761733,
0.020416738465428352,
0.0006279076333157718,
-0.04704361781477928,
0.014686144888401031,
-0.031146615743637085,
-0.007732704747468233,
-0.03471924364566803,
-0.02675875462591648,
-0.007139264605939388,
0.022418849170207977,
-0.01093368511646986,
0.010580018162727356,
-0.010723882354795933,
0.006965428590774536,
0.001456625759601593,
-0.00027461591525934637,
-0.03814800828695297,
-0.0009838218102231622,
-0.015944957733154297,
0.0025670782197266817,
-0.0059104240499436855,
-0.04104927182197571,
-0.004579679574817419,
0.006593779195100069,
-0.008493986912071705,
-0.013163580559194088,
-0.0012977756559848785,
-0.0009471064549870789,
0.03378412500023842,
0.00382439186796546,
0.04548508673906326,
-0.018918151035904884,
0.006174175068736076,
-0.0141706308349967,
-0.0326092354953289,
-0.021231969818472862,
0.010148425586521626,
0.031218547374010086,
0.027286257594823837,
-0.01294778473675251,
0.02755000814795494,
-0.011455193161964417,
0.00689949095249176,
-0.039179038256406784,
-0.005769556853920221,
-0.00974680483341217,
0.0321057103574276,
-0.01251619216054678,
0.030954796820878983,
-0.03004365600645542,
0.0565866157412529,
0.005574740469455719,
-0.031026728451251984,
-0.005337963812053204,
-0.004990291781723499,
0.00855992455035448,
-0.013139603659510612,
0.010268312878906727,
-0.010304278694093227,
0.0005923162098042667,
0.010130442678928375,
-0.0041121202521026134,
0.013223524205386639,
0.0063480110839009285,
0.014446370303630829,
0.022239018231630325,
0.020656511187553406,
0.045772816985845566,
0.002292836783453822,
0.0161247868090868,
-0.0021954288240522146,
-0.009596945717930794,
-0.009956606663763523,
-0.027693873271346092,
0.009129387326538563,
-0.03541458770632744,
-0.036014024168252945,
-0.009620923548936844,
0.007516908459365368,
0.01539347693324089,
-0.0243130624294281,
0.012767953798174858,
0.056155022233724594,
0.032657191157341,
0.009770781733095646,
0.052078865468502045,
0.020045088604092598,
-0.003144033718854189,
-0.015453420579433441,
0.02522420324385166,
-0.004076154436916113,
0.0564427487552166,
-0.026375116780400276,
-0.013990800827741623,
-0.0014693636912852526,
-0.007426992990076542,
-0.003944278694689274,
0.015513364225625992,
0.023042261600494385,
-0.004097134806215763,
0.0041121202521026134,
-0.0645950585603714,
0.0036325729452073574,
-0.01053805835545063,
-0.01686808653175831,
0.02105213887989521,
-0.0016589348670095205,
0.0022538735065609217,
0.04210427775979042,
-0.002318312879651785,
-0.04939340054988861,
0.04179257154464722,
0.035270724445581436,
0.03980245068669319,
0.02279049903154373,
-0.011089537292718887,
-0.005290009081363678,
-0.03814800828695297,
0.01089172437787056,
-0.021555664017796516,
0.004229010082781315,
0.0006267836433835328,
-0.003851366462185979,
0.031002750620245934,
0.03774039447307587,
-0.008320150896906853,
-0.03658948093652725,
0.01946963183581829,
-0.023977378383278847,
-0.004064165521413088,
-0.04673191159963608,
0.014518302865326405,
0.032633211463689804,
-0.01696399599313736,
-0.00932720024138689,
0.0005814514588564634,
0.0067076715640723705,
-0.03963460773229599,
-0.01771928369998932,
0.04630031809210777,
0.007798642385751009,
0.02522420324385166,
-0.0007560367230325937,
0.026255229488015175,
0.031961847096681595,
0.026998529210686684,
0.022286973893642426,
-0.011856813915073872,
-0.03661345690488815,
0.003566635074093938,
-0.0028323279693722725,
-0.046516116708517075,
0.005101187154650688,
0.005643675569444895,
-0.01948161981999874,
-0.007001394405961037,
0.008727765642106533,
0.06195754557847977,
-0.02270657755434513,
0.020788388326764107,
-0.000016835678252391517,
0.01709587126970291,
0.009441092610359192,
-0.0020006124395877123,
0.01940968818962574,
0.0056556640192866325,
-0.027957623824477196,
-0.024864541366696358,
0.030882863327860832,
-0.01330744568258524,
0.04594065621495247,
0.0009733317419886589,
0.002033581491559744,
-0.0320577546954155,
-0.011509141884744167,
0.014398415572941303,
0.0324653722345829,
-0.012444259598851204,
-0.011173458769917488,
-0.009111404418945312,
-0.006395965814590454,
0.010819791816174984,
0.043135304003953934,
0.03083490952849388,
0.022322939708828926,
0.006593779195100069,
0.033616285771131516,
0.006809575483202934,
0.019913213327527046,
0.00374047108925879,
0.00629406189545989,
-0.006132214795798063,
0.004423826467245817,
-0.01951758563518524,
0.004438812378793955,
-0.011239396408200264,
-0.012396304868161678,
-0.02508033812046051,
-0.00017233741527888924,
0.030283428728580475,
0.04524531215429306,
0.007211196701973677,
-0.02920444682240486,
-0.0007935013854876161,
0.04380667209625244,
-0.019853269681334496,
-0.012791931629180908,
0.01492591854184866,
-0.0020875304471701384,
-0.026878641918301582,
0.015141714364290237,
0.00011717070447048172,
-0.03325662389397621,
0.008146314881742,
0.03735675662755966,
-0.009075437672436237,
0.007438981905579567,
-0.01848655939102173,
0.010244335047900677,
-0.01789911277592182,
-0.028964674100279808,
0.014841997064650059,
-0.025368066504597664,
-0.03069104440510273,
-0.0067076715640723705,
-0.021495720371603966,
-0.022227030247449875,
-0.018750309944152832,
-0.0027693873271346092,
-0.02181941457092762,
-0.0004454547306522727,
0.048602145165205,
-0.014650178141891956,
-0.01848655939102173,
0.013187558390200138,
-0.009297228418290615,
-0.0003045876510441303,
-0.02515226975083351,
0.04665997996926308,
-0.01292380690574646,
-0.03493504226207733,
0.03505492955446243,
0.04140893369913101,
-0.0030481242574751377,
0.008565918542444706,
0.001379448571242392,
-0.011041582562029362,
0.02500840649008751,
0.0015929971123114228,
0.009872686117887497,
-0.024420959874987602,
0.03172207251191139,
0.03661345690488815,
-0.00936916097998619,
-0.02193930186331272,
0.0012258434435352683,
0.023989368230104446,
-0.004909368231892586,
0.022167086601257324,
-0.0032279547303915024,
0.003716493723914027,
-0.009015494026243687,
0.018366672098636627,
0.003800414502620697,
0.011976700276136398,
0.010753854177892208,
-0.002053063130006194,
0.004993289243429899,
0.00764878373593092,
-0.01165900006890297,
0.0038154004141688347,
0.037596531212329865,
0.026926595717668533,
-0.0002225400530733168,
0.010705899447202682,
-0.009189330041408539,
-0.008128331042826176,
-0.016544390469789505,
-0.02249078080058098,
-0.02750205434858799,
0.04438212886452675,
-0.0321057103574276,
-0.00854194164276123,
0.037644483149051666,
0.029492175206542015,
-0.013103637844324112,
-0.01704791560769081,
0.027238301932811737,
-0.023150159046053886,
-0.008332138881087303,
-0.006216135341674089,
0.01948161981999874,
0.0203088391572237,
-0.018810253590345383,
-0.036853231489658356,
0.009537002071738243,
-0.007391027174890041,
0.008715777657926083,
-0.0005106432363390923,
-0.0024666727986186743,
0.0016004900680854917,
0.006623751018196344,
-0.026447048410773277,
-0.017407577484846115,
0.008661828003823757,
-0.004235004540532827,
0.057018205523490906,
0.014865974895656109,
-0.0017383599188178778,
0.06166981905698776,
-0.01047811470925808,
-0.019673438742756844,
0.004001224879175425,
-0.015201658010482788,
0.008571912534534931,
-0.008973534218966961,
-0.038267895579338074,
-0.012264429591596127,
0.012803920544683933,
0.010304278694093227,
-0.017359621822834015,
-0.01926582306623459,
-0.009483053348958492,
-0.005436870735138655,
-0.020728444680571556,
0.0009193826117552817,
-0.04797873646020889,
-0.010376210324466228,
0.011515135876834393,
0.025296134874224663,
-0.013295456767082214,
-0.01331943366676569,
0.033664241433143616,
-0.018726332113146782,
0.023006295785307884,
0.0142065966501832,
-0.0032639207784086466,
0.03783630207180977,
0.013463297858834267,
0.01949360966682434,
-0.020488670095801353,
0.026327161118388176,
-0.03718891367316246,
0.029564108699560165,
-0.008248218335211277,
-0.0021954288240522146,
0.012066615745425224,
-0.04435814917087555,
-0.02171151712536812,
-0.0406176783144474,
-0.006773609668016434,
-0.012270423583686352,
0.015645239502191544,
-0.005319980904459953,
-0.0283892173320055,
0.009399132803082466,
-0.025679772719740868,
0.014254551380872726,
-0.045724861323833466,
0.017323656007647514,
0.03407185524702072,
-0.002603044267743826,
0.018019000068306923,
0.0007035862072370946,
-0.03740471228957176,
0.018066955730319023,
0.009123392403125763,
-0.028676945716142654,
-0.004576682113111019,
0.00008977467950899154,
0.025368066504597664,
0.007936512120068073,
0.03481515496969223,
0.004678586032241583,
0.016352571547031403,
-0.05044840648770332,
-0.0036775304470211267,
-0.019026050344109535,
-0.014650178141891956,
0.02757398597896099,
0.017575418576598167,
0.025727728381752968,
-0.008739754557609558,
-0.023665672168135643,
-0.021375833079218864,
0.017347633838653564,
-0.028916718438267708,
-0.0007170735043473542,
-0.0003827014588750899,
0.0025041375774890184,
-0.008829670026898384,
-0.02920444682240486,
0.003773439908400178,
0.027981601655483246,
-0.005469839554280043,
-0.014218585565686226,
-0.02108810469508171,
0.0032009801361709833,
-0.05179113894701004,
-0.019793326035141945,
-0.00488239387050271,
0.013067671097815037,
0.011563090607523918,
0.01047211978584528,
0.025487953796982765,
-0.004001224879175425,
0.024396982043981552,
0.02505636028945446,
0.039946313947439194,
-0.01618473045527935,
-0.024061299860477448,
0.018414627760648727,
0.009584956802427769,
-0.010250329039990902,
-0.019805314019322395,
0.019038038328289986,
0.008302167057991028,
-0.00567364739254117,
0.03802812099456787,
0.008218246512115002,
-0.01626865193247795,
0.0038064089603722095,
-0.022910386323928833,
-0.00683954730629921,
-0.00423800153657794,
0.008811687119305134,
-0.010340244509279728,
0.0036415643990039825,
-0.01532154530286789,
-0.0029941750690340996,
0.0011673986446112394,
0.015837058424949646,
0.009447087533771992,
0.005895438138395548,
-0.008314155973494053,
-0.014242563396692276,
-0.06584188342094421,
-0.06166981905698776,
0.004666597582399845,
0.007822619751095772,
-0.022322939708828926,
-0.000638023077044636,
-0.006713666021823883,
0.02275453321635723,
0.042487915605306625,
-0.00608725706115365,
0.011479170061647892,
0.0486501008272171,
0.03632573038339615,
-0.003749462543055415,
-0.008487991988658905,
0.028581036254763603,
0.05040045082569122,
-0.021975267678499222,
0.0070673325099051,
-0.027190348133444786,
-0.01948161981999874,
-0.018834231421351433,
-0.019853269681334496,
0.020788388326764107,
0.0284131933003664,
0.005619698204100132,
0.0163285955786705,
-0.0011614043032750487,
-0.019709404557943344,
0.045676905661821365,
-0.02331800013780594,
-0.023246068507432938,
-0.01691604033112526,
-0.02589556947350502,
-0.012755965813994408,
0.01684410870075226,
0.038363806903362274,
-0.001111950958147645,
-0.008883618749678135,
0.010502091608941555,
0.03558243066072464,
-0.024121243506669998,
-0.033544354140758514,
0.023725615814328194,
0.043183259665966034,
-0.007043355144560337,
0.006000339053571224,
-0.028748877346515656,
-0.020033100619912148,
-0.006033307872712612,
0.030259452760219574,
-0.00889560766518116,
-0.003491705749183893,
-0.012971761636435986,
-0.00523605989292264,
0.013966822996735573,
0.027765804901719093,
0.022215042263269424,
0.010586013086140156,
0.0002086781314574182,
-0.011203430593013763,
-0.02661489136517048,
-0.023881468921899796,
-0.010124447755515575,
-0.01330744568258524,
-0.030235474929213524,
-0.00683954730629921,
0.01854650303721428,
-0.013894891366362572,
0.0010872242273762822,
0.014230574481189251,
0.015621262602508068,
0.04097734019160271,
-0.01626865193247795,
0.0015210650162771344,
0.030379338189959526,
-0.016676267609000206,
-0.0050292550586164,
-0.014410404488444328,
-0.014746087603271008,
-0.01371506042778492,
0.025368066504597664,
-0.02735818922519684,
-0.013463297858834267,
-0.07480942457914352,
-0.010196380317211151,
0.029564108699560165,
-0.01538148894906044,
0.02102816104888916,
0.03579822555184364,
-0.025655794888734818,
0.0161247868090868,
-0.006851536221802235,
-0.0014521300327032804,
-0.0028548066038638353,
0.03862755745649338,
-0.006204146891832352,
-0.01773127168416977,
-0.0006994651048444211,
-0.018414627760648727,
0.007373043801635504,
-0.01876229979097843,
-0.031266503036022186,
0.024049311876296997,
-0.057977303862571716,
0.027813758701086044,
0.010747860185801983,
0.001801300561055541,
-0.0025535908062011003,
0.01622069627046585,
-0.03738073259592056,
-0.0006530089303851128,
0.011940734460949898,
-0.015837058424949646,
0.006863524671643972,
0.04469383507966995,
-0.02579966001212597,
-0.008751743473112583,
0.004696568939834833,
0.027286257594823837,
-0.00764878373593092,
-0.0037614512257277966,
0.03584618121385574,
-0.03829187527298927,
-0.03488708660006523,
0.022023223340511322,
0.00853594671934843,
-0.023737605661153793,
0.012036643922328949,
-0.0243010725826025,
-0.011293345130980015,
0.0007897549076005816,
-0.053037963807582855,
0.00888961274176836,
0.024816587567329407,
0.002110009314492345,
-0.004151083528995514,
0.04339905455708504,
-0.03793221339583397,
0.01328346785157919,
-0.009411120787262917,
0.0037794343661516905,
0.0015795098152011633,
-0.01373903825879097,
-0.0161607526242733,
0.010124447755515575,
0.009956606663763523,
0.005430876277387142,
0.02344987727701664,
-0.009848708286881447,
-0.011521130800247192,
-0.0018462581792846322,
-0.0325612798333168,
-0.008290179073810577,
0.022071177139878273,
-0.008493986912071705,
0.018354684114456177,
0.02193930186331272,
0.020824354141950607,
0.005254043266177177,
0.027933645993471146,
0.026183297857642174,
0.010795814916491508,
-0.014182619750499725,
-0.027214324101805687,
-0.0003073974803555757,
-0.018978094682097435,
-0.0027678885962814093,
0.13168376684188843,
-0.03073900006711483,
-0.028053533285856247,
0.026926595717668533,
-0.006959434133023024,
0.009531008079648018,
0.025679772719740868,
-0.0063360221683979034,
0.02107611671090126,
-0.010825786739587784,
0.015621262602508068,
0.005622695200145245,
0.01128735113888979,
0.03397594764828682,
0.03469526767730713,
-0.00887162983417511,
-0.02026088535785675,
0.03165014088153839,
-0.007337077986449003,
-0.0018567482475191355,
0.00486441096290946,
0.02999570034444332,
-0.011940734460949898,
0.014770065434277058,
-0.03289696201682091,
-0.01015441957861185,
-0.015956945717334747,
-0.014302506111562252,
0.027693873271346092,
0.004666597582399845,
0.025535907596349716,
-0.03500697389245033,
0.032633211463689804,
-0.006611762102693319,
-0.007181224878877401,
-0.010022544302046299,
0.007702732924371958,
-0.00851796381175518,
-0.002316814148798585,
0.01870235614478588,
-0.008649839088320732,
0.015213646925985813,
-0.008733760565519333,
0.01251619216054678,
0.03174604848027229,
0.048074644058942795,
-0.016784165054559708,
0.010813797824084759,
0.013870913535356522,
-0.011275362223386765,
0.016796153038740158,
-0.004019208252429962,
0.020476682111620903,
-0.031817980110645294,
-0.01618473045527935,
-0.016448481008410454,
0.032753098756074905,
-0.016412515193223953,
0.005080207251012325,
-0.028437171131372452,
0.0008744250517338514,
0.010681922547519207,
0.0005488572060130537,
0.013487275689840317,
-0.010226352140307426
] | 2024-06-28 | 1 | 38936505 | [
"CAR)-T cell therapy",
"regulated cell death",
"Immunogenic cell death",
"anti-tumor immunotherapy",
"solid tumors",
"tumor antigen heterogeneity",
"anti-tumor capacity",
"ICD induction therapy",
"tumors",
"CAR-T cell immunotherapy",
"ICD",
"tumor cells specific signaling pathways",
"CAR-T cell",
"CAR-T cells",
"the robust anti-tumor immune response",
"Chimeric antigen receptor",
"various ICD-based therapies",
"hematologic malignancies",
"the tumor immune microenvironment",
"damage-associated molecular patterns",
"DAMPs",
"physical and immune barriers",
"stress-responsive mechanism",
"absence",
"CAR)-T",
"Gordian",
"a stress-driven form",
"the synergistic effect",
"a formidable role",
"the intensive use"
] | [] | 0 | 10.1016/j.canlet.2024.217079 | [
"Zhou",
"Mai",
"Zhang",
"Wang",
"Sun",
"Jing",
"Li",
"Xu",
"Han",
"Liu"
] | [
"Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Henan Province Key Laboratory of Cardiac Injury and Repair, Henan Province Clinical Research Center for Cardiovascular Diseases, Zhengzhou, Henan, 450052, China.",
"Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.",
"Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"State Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address: [email protected].",
"Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. Electronic address: [email protected]."
] | [
"38936505"
] | [] | 10.4886 | 4.21411 |
38928301 | 799 | A Review of CAR-T Combination Therapies for Treatment of Gynecological Cancers. | CAR-T cell therapy offers a promising way for prolonged cancer remission, specifically in the case of blood cancers. However, its application in the treatment of solid tumors still faces many limitations. This review paper provides a comprehensive overview of the challenges and strategies associated with CAR-T cell therapy for solid tumors, with a focus on gynecological cancer. This study discusses the limitations of CAR-T therapy for solid tumor treatment, such as T cell exhaustion, stromal barrier, and antigen shedding. Additionally, it addresses possible approaches to increase CAR-T efficacy in solid tumors, including combination therapies with checkpoint inhibitors and chemotherapy, as well as the novel approach of combining CAR-T with oncolytic virotherapy. Given the lack of comprehensive research on CAR-T combination therapies for treating gynecological cancers, this review aims to provide insights into the current landscape of combination therapies for solid tumors and highlight the potential of such an approach in gynecology. | [
0.015400252304971218,
0.04752800241112709,
0.04773867502808571,
0.054269563406705856,
-0.06526673585176468,
-0.020909370854496956,
0.02823028527200222,
0.019961340352892876,
0.057935286313295364,
-0.0018763132393360138,
-0.011745062656700611,
-0.03739459440112114,
-0.029388990253210068,
-0.005925199948251247,
-0.009848998859524727,
-0.012408684939146042,
0.04015441983938217,
0.02643955871462822,
0.0380687490105629,
0.03244376182556152,
0.02930472232401371,
0.015589859336614609,
0.015147443860769272,
-0.030400225892663002,
-0.04499991610646248,
0.014315282925963402,
0.038153018802404404,
0.024690965190529823,
-0.05110945552587509,
-0.04266143962740898,
0.012155876494944096,
-0.01572679728269577,
-0.024817369878292084,
-0.07120773196220398,
-0.022942373529076576,
0.0512358620762825,
0.055322930216789246,
0.022226082161068916,
0.012777363881468773,
-0.001598487258888781,
0.03905891627073288,
0.0333285890519619,
0.04011228680610657,
0.08443804830312729,
-0.05456450581550598,
0.028146015480160713,
0.012166410684585571,
-0.07200829684734344,
-0.019508391618728638,
-0.029957810416817665,
-0.033286456018686295,
0.008990502916276455,
0.0015471355291083455,
-0.014399551786482334,
-0.035919878631830215,
-0.002965233288705349,
-0.03800554946064949,
0.021372854709625244,
0.012556157074868679,
0.019624261185526848,
-0.030084215104579926,
0.0038000282365828753,
0.03610948473215103,
-0.027808938175439835,
-0.03653082996606827,
0.015337050892412663,
-0.03259123116731644,
-0.009116907604038715,
-0.012292814441025257,
0.012155876494944096,
-0.0008742961217649281,
-0.012187477201223373,
-0.00598313519731164,
0.01867622882127762,
0.032106682658195496,
0.00399226788431406,
0.017686063423752785,
0.040428295731544495,
0.02705051191151142,
-0.008674492128193378,
0.05755607411265373,
-0.029620731249451637,
0.014094075188040733,
-0.006472951732575893,
-0.01173452939838171,
0.0002909931354224682,
-0.016369352117180824,
-0.03535106033086777,
-0.02681877091526985,
0.004521586000919342,
-0.03606734797358513,
0.02109897881746292,
-0.023426923900842667,
0.044747110456228256,
0.0022278751712292433,
0.002608404727652669,
0.01441008597612381,
-0.03882717713713646,
0.02180473506450653,
0.019824402406811714,
0.03514038398861885,
0.029978876933455467,
-0.04224009066820145,
-0.004208208527415991,
0.05751394107937813,
-0.008442751131951809,
-0.06749987602233887,
-0.007889732718467712,
0.03657296672463417,
0.025575796142220497,
0.05380608141422272,
-0.03608841821551323,
-0.01536865159869194,
0.03252803161740303,
-0.0041739740408957005,
-0.04752800241112709,
-0.010017537511885166,
0.017686063423752785,
-0.01679069921374321,
0.048075754195451736,
-0.006867964752018452,
0.04563193768262863,
0.00619907584041357,
-0.04040722921490669,
0.02549152635037899,
-0.027345456182956696,
0.060674045234918594,
-0.03598307818174362,
-0.02761933207511902,
-0.044704973697662354,
0.007752794772386551,
-0.007004902698099613,
0.011197310872375965,
-0.024754168465733528,
-0.049719009548425674,
0.011386916972696781,
-0.025997143238782883,
0.011323715560138226,
0.014367951080203056,
-0.02536512166261673,
0.008063538931310177,
-0.004748059902340174,
-0.01738058589398861,
-0.00738411583006382,
-0.005846197251230478,
-0.03644656389951706,
0.013778064399957657,
0.01942412182688713,
-0.020266816020011902,
0.07360941171646118,
-0.0184550229460001,
0.07091279327869415,
0.08081445842981339,
-0.038995712995529175,
-0.01428368128836155,
-0.01190306805074215,
-0.006757361348718405,
0.0845223143696785,
-0.018265414983034134,
-0.05136226490139961,
0.000890755036380142,
-0.005572321359068155,
-0.01029141340404749,
-0.023721866309642792,
0.01536865159869194,
-0.0160954762250185,
0.004942933563143015,
-0.003965933807194233,
-0.045084185898303986,
-0.027914274483919144,
0.001522117992863059,
-0.08422737568616867,
-0.03623588755726814,
0.0041976748034358025,
-0.049002718180418015,
0.0034761172719299793,
0.011450119316577911,
0.03132718801498413,
-0.020277351140975952,
0.0006734977359883487,
0.011766130104660988,
0.026271019130945206,
0.012429752387106419,
-0.00917484238743782,
-0.021151646971702576,
0.016390418633818626,
0.024396022781729698,
0.022478891536593437,
-0.035456396639347076,
-0.024374954402446747,
-0.004237176384776831,
-0.028419891372323036,
0.027345456182956696,
0.03954346850514412,
-0.002744025783613324,
-0.018423421308398247,
-0.0009091889951378107,
0.0021330718882381916,
-0.025280851870775223,
0.01315657701343298,
0.04154486581683159,
-0.00634654751047492,
-0.031748536974191666,
-0.006615156307816505,
-0.03539319336414337,
-0.054985854774713516,
-0.005851463880389929,
0.0232162494212389,
-0.025660065934062004,
0.012050539255142212,
0.011039305478334427,
0.0020632862579077482,
-0.014894635416567326,
0.03206454962491989,
0.0043767476454377174,
-0.029810339212417603,
0.013904469087719917,
0.019982406869530678,
0.04297744855284691,
0.02654489502310753,
0.00015652402362320572,
0.02193113975226879,
-0.026292085647583008,
0.0037499931640923023,
0.004342513158917427,
0.003721025539562106,
0.04143952950835228,
-0.03636229410767555,
-0.00013010750990360975,
-0.012882701121270657,
-0.013609525747597218,
-0.0044715506955981255,
0.0008795629837550223,
-0.00020820493227802217,
-0.0025952374562621117,
-0.046516768634319305,
0.020256282761693,
0.004877097904682159,
0.018907971680164337,
0.01470502931624651,
0.032464828342199326,
0.037204988300800323,
0.03838476166129112,
-0.0345294326543808,
-0.003697324777022004,
-0.02205754444003105,
-0.027956409379839897,
-0.07992962747812271,
0.021994341164827347,
-0.005582855083048344,
0.014789299108088017,
0.005280011333525181,
0.010244011878967285,
0.01582160033285618,
0.02702944539487362,
-0.00923804473131895,
0.028862306848168373,
-0.025744333863258362,
0.009864799678325653,
-0.05801955610513687,
-0.0024741000961512327,
-0.006509819533675909,
-0.04432576149702072,
-0.0917694941163063,
-0.08730321377515793,
0.004342513158917427,
-0.006220143288373947,
-0.011882000602781773,
0.048792045563459396,
-0.005190474912524223,
0.036741506308317184,
0.014336350373923779,
0.046053286641836166,
-0.010280880145728588,
-0.0392906591296196,
0.007047037594020367,
-0.0011271046241745353,
-0.0009421067661605775,
0.010470486246049404,
0.019866537302732468,
0.004239809699356556,
0.005630256608128548,
-0.008332147262990475,
-0.015631994232535362,
0.020993640646338463,
-0.007821263745427132,
0.0065519544295966625,
0.026481693610548973,
0.002520184963941574,
-0.004576887469738722,
0.008379548788070679,
0.02071976475417614,
0.00039534250390715897,
0.016000673174858093,
0.014389018528163433,
0.009053705260157585,
0.0024885840248316526,
0.007378848735243082,
-0.01833915151655674,
0.013377784751355648,
-0.052836980670690536,
0.03476117178797722,
0.008395349606871605,
-0.02357439510524273,
0.006009469274431467,
0.01316711027175188,
0.003744726302102208,
-0.031601063907146454,
0.025870738551020622,
0.04849710315465927,
0.030758369714021683,
-0.05262630805373192,
0.027914274483919144,
0.03370780497789383,
-0.005385348107665777,
0.03301258012652397,
0.03393954411149025,
-0.054269563406705856,
0.005282644648104906,
-0.05249990522861481,
-0.030063146725296974,
-0.015495055355131626,
-0.04419935867190361,
0.05692405253648758,
-0.0017828267300501466,
-0.04462070390582085,
0.02999994531273842,
-0.02060389518737793,
0.05346900224685669,
-0.036741506308317184,
-0.025870738551020622,
-0.045252725481987,
0.04301958531141281,
-0.025891806930303574,
0.001407564152032137,
-0.02416428178548813,
-0.025912873446941376,
-0.014073007740080357,
0.03827942535281181,
0.0039949011988937855,
0.025449391454458237,
0.025301920250058174,
-0.048539236187934875,
0.07053358107805252,
-0.021994341164827347,
0.012745763175189495,
0.02367973141372204,
0.04297744855284691,
0.00804773811250925,
0.039585601538419724,
0.014989438466727734,
-0.001233758288435638,
0.007947668433189392,
0.035919878631830215,
0.002208124380558729,
0.020530158653855324,
-0.02892550826072693,
-0.02892550826072693,
0.025638997554779053,
-0.0055670542642474174,
0.01190306805074215,
-0.009422384202480316,
-0.048749908804893494,
0.03762633353471756,
0.04183981195092201,
0.07811783254146576,
-0.03646763041615486,
0.04622182622551918,
-0.06446617096662521,
-0.01987707056105137,
-0.007310379762202501,
0.004887631628662348,
0.006588822230696678,
-0.0005184549954719841,
-0.018391819670796394,
0.05249990522861481,
-0.012461353093385696,
0.036846842616796494,
-0.0015853201039135456,
-0.022457823157310486,
-0.0016208713641390204,
-0.016706429421901703,
-0.0285673625767231,
-0.01095503568649292,
-0.0208567027002573,
0.034108083695173264,
0.004442583303898573,
-0.01571626402437687,
-0.07870771735906601,
-0.0002979058772325516,
-0.014146743342280388,
-0.006546687334775925,
0.008648158051073551,
-0.01048102043569088,
0.0026228884235024452,
0.07546334713697433,
-0.03800554946064949,
0.05983135104179382,
0.03356033191084862,
-0.023553326725959778,
0.014789299108088017,
-0.030526628717780113,
-0.014568091370165348,
-0.01279843132942915,
0.01143958605825901,
-0.04596901684999466,
0.048075754195451736,
0.020540691912174225,
0.04988754913210869,
-0.016148144379258156,
0.005280011333525181,
0.0003076166321989149,
0.01645362190902233,
0.022015409544110298,
0.022015409544110298,
-0.028167083859443665,
-0.007847597822546959,
0.05709259212017059,
-0.028862306848168373,
0.02252102643251419,
0.051404401659965515,
-0.0023226782213896513,
0.010976103134453297,
-0.03554066643118858,
0.012134809046983719,
0.019845468923449516,
0.02643955871462822,
0.00657828850671649,
-0.019866537302732468,
-0.0488763153553009,
-0.03313898295164108,
0.05608135834336281,
0.023616530001163483,
-0.01834968477487564,
0.004463650286197662,
0.048286426812410355,
-0.010086006484925747,
0.04550553485751152,
-0.01584266684949398,
-0.01751752384006977,
-0.042935315519571304,
-0.002983667189255357,
0.02011934481561184,
-0.012240146286785603,
0.015147443860769272,
-0.008985236287117004,
0.02930472232401371,
0.026271019130945206,
-0.02582860365509987,
-0.014810365624725819,
-0.015126376412808895,
0.013072307221591473,
-0.006314946338534355,
0.0032601766288280487,
-0.04011228680610657,
0.02275276742875576,
0.008358482271432877,
-0.06577235460281372,
0.0022621096577495337,
-0.010702227242290974,
0.06669931858778,
-0.04202941805124283,
0.028293486684560776,
-0.02157299406826496,
-0.005056170281022787,
0.040786441415548325,
0.05077238008379936,
-0.005366914439946413,
-0.027914274483919144,
-0.021762600168585777,
0.021509792655706406,
-0.014610226266086102,
-0.031116515398025513,
-0.0047059254720807076,
-0.02191007137298584,
0.04845496639609337,
0.0024306485429406166,
0.026228884235024452,
-0.008674492128193378,
0.02466989867389202,
-0.027851073071360588,
0.010965569876134396,
-0.02799854427576065,
-0.003689424367621541,
0.013009104877710342,
-0.000632350507657975,
-0.02000347524881363,
0.018971173092722893,
0.0009091889951378107,
0.034108083695173264,
-0.01773873157799244,
0.007657991722226143,
0.003070570295676589,
-0.006541420705616474,
-0.04356733709573746,
-0.020066676661372185,
-0.009949068538844585,
-0.010639025829732418,
-0.02582860365509987,
0.004634822718799114,
0.004985067993402481,
0.009448718279600143,
0.013577924109995365,
-0.009870066307485104,
0.042956382036209106,
0.020161479711532593,
0.011186777614057064,
0.05469091236591339,
0.03311791643500328,
0.005169407464563847,
-0.057218994945287704,
-0.021741533651947975,
0.06514032930135727,
0.00506407069042325,
-0.01809687726199627,
0.00047006586100906134,
-0.06202235817909241,
-0.012377084232866764,
-0.007047037594020367,
-0.01553719025105238,
-0.00917484238743782,
-0.004334612749516964,
-0.03528785705566406,
-0.012240146286785603,
-0.018992239609360695,
-0.022331420332193375,
-0.007721193600445986,
-0.023131979629397392,
0.015874268487095833,
-0.00857442244887352,
-0.009132707491517067,
-0.008263678289949894,
-0.02751399390399456,
0.016285082325339317,
-0.01369379460811615,
-0.024943774566054344,
-0.04588474705815315,
0.01740165427327156,
-0.028146015480160713,
-0.043988682329654694,
0.000540509878192097,
-0.02464883029460907,
0.03259123116731644,
-0.014094075188040733,
0.003241742728278041,
0.0202457495033741,
-0.013061773963272572,
-0.01506317500025034,
0.007426250260323286,
-0.00797400251030922,
0.006904833018779755,
-0.05195215344429016,
0.020877771079540253,
0.004015968646854162,
0.02871483564376831,
-0.019329318776726723,
-0.020035075023770332,
-0.019961340352892876,
0.00177229312248528,
-0.028188150376081467,
-0.0022265585139393806,
-0.0064676846377551556,
0.011429051868617535,
-0.008474352769553661,
-0.0019105477258563042,
0.032464828342199326,
-0.009022104553878307,
0.004982434678822756,
-0.03417128697037697,
0.015358117409050465,
0.011681860312819481,
-0.0005938367103226483,
0.034466229379177094,
-0.037120718508958817,
0.022331420332193375,
-0.009801597334444523,
0.015115843154489994,
0.007926600985229015,
-0.008437484502792358,
0.019129177555441856,
-0.04000695049762726,
-0.015358117409050465,
0.006046337075531483,
0.03754206746816635,
-0.015990139916539192,
0.017717663198709488,
-0.028630565851926804,
0.011271046474575996,
-0.004642723128199577,
0.01690657064318657,
0.02846202626824379,
-0.011102507822215557,
0.03406594693660736,
0.01160812471061945,
-0.038511164486408234,
0.006831096950918436,
-0.00989113375544548,
-0.0003268735308665782,
-0.002288443734869361,
-0.016348283737897873,
-0.01690657064318657,
-0.01183986570686102,
-0.008685026317834854,
-0.039122119545936584,
-0.03870077058672905,
0.023279450833797455,
0.02418534830212593,
-0.03644656389951706,
0.036025214940309525,
0.004524219315499067,
0.044367894530296326,
0.04348306730389595,
-0.032464828342199326,
-0.019002774730324745,
0.0038079284131526947,
0.0014615493128076196,
-0.035919878631830215,
-0.004676957614719868,
-0.003697324777022004,
-0.013630593195557594,
-0.0036314891185611486,
-0.010891834273934364,
-0.025344055145978928,
-0.020888304337859154,
0.006035803351551294,
-0.04274570941925049,
-0.03396061062812805,
-0.011871467344462872,
0.015126376412808895,
0.02681877091526985,
-0.0016511556459590793,
-0.03676257282495499,
0.0028572629671543837,
0.007162908092141151,
-0.010528421960771084,
-0.036256954073905945,
0.005867264699190855,
-0.010912901721894741,
-0.0002312473807251081,
-0.02584967203438282,
-0.030779438093304634,
-0.0002289431431563571,
0.016242947429418564,
-0.020519625395536423,
0.022205015644431114,
-0.008758761920034885,
-0.014136210083961487,
-0.018728898838162422,
-0.01524224691092968,
0.00591993285343051,
0.003539319382980466,
-0.0036314891185611486,
0.013978204689919949,
-0.03145359456539154,
0.0037578933406621218,
0.013609525747597218,
0.021141113713383675,
0.011197310872375965,
0.0345715656876564,
0.052247095853090286,
-0.04668530821800232,
0.014557557180523872,
-0.006267544813454151,
-0.012240146286785603,
-0.01303017232567072,
0.014030872844159603,
-0.0000222400722122984,
-0.00017528716125525534,
0.01764392852783203,
0.011723995208740234,
0.0691431313753128,
0.03250696137547493,
-0.007837064564228058,
-0.024627763777971268,
-0.007189242634922266,
0.04314598813652992,
0.01976119913160801,
-0.03393954411149025,
-0.028188150376081467,
0.02395360730588436,
-0.03035809099674225,
-0.0013404118362814188,
-0.03179067373275757,
-0.009122174233198166,
-0.0232373159378767,
-0.024712033569812775,
0.021056843921542168,
0.03145359456539154,
0.005535453092306852,
-0.012672027572989464,
0.016390418633818626,
-0.039374928921461105,
-0.021404454484581947,
0.007410449907183647,
-0.0016248214524239302,
0.029957810416817665,
-0.013325115665793419,
-0.028672700747847557,
-0.0178651362657547,
-0.016759097576141357,
-0.00013973595923744142,
0.016485221683979034,
0.022310351952910423,
-0.03417128697037697,
0.03168533369898796,
-0.004937666468322277,
0.008674492128193378,
-0.011492254212498665,
-0.007958201691508293,
0.015231713652610779,
-0.007431517355144024,
-0.0017880935920402408,
-0.026249952614307404,
0.007452584803104401,
0.018191680312156677,
0.01262989267706871,
-0.01358845829963684,
0.018128477036952972,
0.029346855357289314,
0.029620731249451637,
-0.02060389518737793,
0.04323025792837143,
-0.00851122010499239,
0.008058271370828152,
0.021109512075781822,
0.023869337514042854,
-0.028419891372323036,
0.041292060166597366,
-0.024227483198046684,
-0.01428368128836155,
0.026144614443182945,
-0.014009805396199226,
-0.03461369872093201,
-0.002314778044819832,
-0.025744333863258362,
0.007663258351385593,
-0.018391819670796394,
0.0024280152283608913,
0.00420294189825654,
0.0061464072205126286,
0.03309684991836548,
-0.019813867285847664,
-0.03478223830461502,
0.01513691060245037,
-0.004171340726315975,
0.003939599730074406,
-0.0037736939266324043,
0.0017354252049699426,
0.01501050591468811,
-0.026144614443182945,
0.018613027408719063,
0.004647990223020315,
0.021488724276423454,
-0.026523828506469727,
0.008969435468316078,
-0.016042808070778847,
-0.024754168465733528,
0.0038579634856432676,
-0.03878504037857056,
-0.03979627415537834,
-0.026966242119669914,
-0.007426250260323286,
0.00768432579934597,
-0.017106710001826286,
-0.016727497801184654,
0.030821572989225388,
0.018528757616877556,
0.017707129940390587,
-0.0010316431289538741,
0.006488752085715532,
-0.01881316676735878,
-0.02443815767765045,
0.018613027408719063,
-0.027219051495194435,
-0.019971873611211777,
0.011355316266417503,
-0.022205015644431114,
0.027556128799915314,
-0.01108144037425518,
0.031369324773550034,
0.02774573490023613,
0.009864799678325653,
-0.010154475457966328,
0.024627763777971268,
0.009912201203405857,
-0.02334265410900116,
0.00863762479275465,
0.034592632204294205,
-0.028778037056326866,
-0.02515444904565811,
-0.003913265187293291,
0.032717637717723846,
-0.01774926483631134,
0.023005574941635132,
-0.007663258351385593,
0.022015409544110298,
0.03503504768013954,
-0.06353920698165894,
-0.008611290715634823,
0.005237876437604427,
-0.023637596517801285,
-0.0038737638387829065,
-0.006415016483515501,
-0.03682577610015869,
0.005967334378510714,
0.03122185356914997,
-0.012450819835066795,
0.011681860312819481,
-0.041502732783555984,
0.008753495290875435,
0.013377784751355648,
0.0001509280118625611,
-0.007700126152485609,
-0.017896736040711403,
-0.051867883652448654,
0.004766494035720825,
0.02799854427576065,
-0.015874268487095833,
0.010312480852007866,
0.004260877147316933,
0.05911505967378616,
-0.007752794772386551,
-0.013135509565472603,
-0.00917484238743782,
-0.03120078518986702,
-0.04023868963122368,
-0.03682577610015869,
-0.010143942199647427,
0.030168483033776283,
-0.02050909213721752,
0.046053286641836166,
-0.012619358487427235,
-0.05709259212017059,
0.01428368128836155,
-0.002314778044819832,
-0.015347584150731564,
0.0066625578328967094,
0.018412888050079346,
0.01417834497988224,
0.03107438050210476,
0.007073371671140194,
-0.040196556597948074,
-0.036130551248788834,
-0.01741218753159046,
0.006509819533675909,
-0.001848662388511002,
-0.007431517355144024,
0.011702927760779858,
-0.0369521789252758,
-0.02812494896352291,
-0.045084185898303986,
-0.01233494933694601,
-0.011502787470817566,
0.0226263627409935,
0.037457797676324844,
0.008484886027872562,
0.017117243260145187,
-0.040196556597948074,
0.023658664897084236,
0.04251396656036377,
0.003721025539562106,
-0.024374954402446747,
-0.015147443860769272,
-0.010407283902168274,
0.015094775706529617,
-0.05852517485618591,
0.007505252957344055,
-0.007499986328184605,
-0.02989460714161396,
-0.023553326725959778,
0.026144614443182945,
0.0007432833663187921,
0.014252080582082272,
-0.0058725313283503056,
-0.010275613516569138,
-0.006393949035555124,
0.0369521789252758,
-0.03975414112210274,
-0.006604622583836317,
-0.009064238518476486,
0.013051239773631096,
-0.015568791888654232,
0.016948705539107323,
-0.020656563341617584,
0.014578624628484249,
0.026713434606790543,
-0.025449391454458237,
0.004358313512057066,
-0.015021040104329586,
-0.010828631930053234,
0.00940658338367939,
-0.027492927387356758,
-0.02717691659927368,
0.009754195809364319,
0.0001158705708803609,
0.006478218361735344,
0.0006247793789952993,
0.016148144379258156,
-0.0220364760607481,
-0.021457122638821602,
0.006383415311574936,
-0.03682577610015869,
-0.011292113922536373,
0.048749908804893494,
0.026397423818707466,
0.0022989774588495493,
-0.03084263950586319,
0.013188177719712257,
-0.02572326734662056,
0.027935341000556946,
-0.0012330999597907066,
-0.0038079284131526947,
0.017664995044469833,
0.03644656389951706,
0.002441182266920805,
0.017707129940390587,
-0.0184760894626379,
0.06366561353206635,
0.011239445768296719,
-0.0014628659700974822,
-0.005698725581169128,
-0.0013799131847918034,
0.005435383412986994,
-0.02999994531273842,
-0.01202947273850441,
-0.004008068703114986,
0.018370753154158592,
0.028272420167922974,
0.015231713652610779,
0.018907971680164337,
0.005524919833987951,
0.013304048217833042,
0.026966242119669914,
-0.002508334582671523,
0.01763339526951313,
0.013735929504036903,
0.011860933154821396,
-0.00440571503713727,
-0.01917131245136261,
-0.012061073444783688,
-0.03787914291024208,
0.03025275282561779,
-0.038532231003046036,
-0.039480265229940414,
0.0020540691912174225,
0.03383420780301094,
-0.0041344729252159595,
-0.04108138382434845,
0.00881143007427454,
0.037689536809921265,
0.06648863852024078,
0.012419219128787518,
0.019697997719049454,
0.0030969043727964163,
-0.007057571318000555,
-0.035308923572301865,
0.007747527677565813,
-0.015105308964848518,
0.04740159958600998,
-0.03653082996606827,
-0.0321488156914711,
0.04095498099923134,
-0.020804034546017647,
-0.01748592220246792,
0.02050909213721752,
0.035077184438705444,
-0.006472951732575893,
-0.009485586546361446,
-0.01931878551840782,
0.03990161046385765,
0.03238055855035782,
-0.012366550043225288,
0.03632015734910965,
-0.008685026317834854,
0.014884102158248425,
0.02367973141372204,
0.010923434980213642,
-0.02431175298988819,
-0.0052536772564053535,
0.0046822247095406055,
0.008906234055757523,
0.018254881724715233,
-0.04080750793218613,
-0.023426923900842667,
-0.04390441253781319,
-0.0086323581635952,
-0.007199775893241167,
-0.009564588777720928,
-0.011776663362979889,
0.009211710654199123,
0.02810388058423996,
0.03132718801498413,
-0.0190554428845644,
0.005619722884148359,
0.008358482271432877,
-0.03280190750956535,
-0.00479809520766139,
-0.020087743178009987,
0.028019610792398453,
0.049002718180418015,
-0.026608096435666084,
-0.03107438050210476,
0.02643955871462822,
0.014968371018767357,
-0.03773167356848717,
-0.023174114525318146,
0.004958733916282654,
0.01041781809180975,
0.03071623481810093,
-0.049466200172901154,
0.026966242119669914,
-0.013335649855434895,
0.027577197179198265,
-0.004808628931641579,
0.00013520976062864065,
-0.024943774566054344,
-0.015379184857010841,
-0.024627763777971268,
-0.03349712863564491,
-0.019213447347283363,
-0.04453643411397934,
-0.009190643206238747,
0.009617257863283157,
0.03756313398480415,
0.017075108364224434,
0.017106710001826286,
-0.00001876313217508141,
-0.03372887149453163,
0.019276650622487068,
0.00910110678523779,
0.01524224691092968,
0.008537554182112217,
0.005514386110007763,
-0.026292085647583008,
-0.025870738551020622,
0.0042687770910561085,
0.00000660927253193222,
0.055575739592313766,
-0.012282281182706356,
0.03785807639360428,
-0.05566000938415527,
-0.0008499369723722339,
0.013609525747597218,
0.03356033191084862,
-0.028672700747847557,
-0.008089873008430004,
0.006546687334775925,
-0.0004891581484116614,
0.009285446256399155,
0.019613727927207947,
0.030042080208659172,
0.04499991610646248,
0.027492927387356758,
0.015642527490854263,
-0.009111640974879265,
0.013957137241959572,
0.0244170892983675,
0.0028598965145647526,
0.0016327217454090714,
-0.01740165427327156,
-0.016021739691495895,
0.05136226490139961,
0.01256669033318758,
0.005946266930550337,
-0.027598263695836067,
0.009306513704359531,
0.009848998859524727,
0.01161865796893835,
0.00910637341439724,
-0.02667129971086979,
0.018160078674554825,
0.0017749265534803271,
-0.04959260672330856,
0.012766830623149872,
-0.009143241681158543,
0.00432144571095705,
-0.0014404818648472428,
-0.000644200888928026,
0.014957837760448456,
-0.013830732554197311,
-0.0017341084312647581,
0.008563889190554619,
0.018507691100239754,
-0.006588822230696678,
-0.012450819835066795,
-0.001422047964297235,
-0.05321619287133217,
-0.004281944595277309,
0.0026623897720128298,
0.0016248214524239302,
-0.016527356579899788,
-0.0025452023837715387,
-0.02515444904565811,
0.009722594171762466,
-0.02001400850713253,
0.001431264914572239,
0.009754195809364319,
-0.011797730810940266,
0.028904441744089127,
-0.00455318670719862,
-0.023068778216838837,
0.0279774758964777,
0.008542821742594242,
-0.05292125046253204,
-0.026376355439424515,
0.043272390961647034,
-0.006604622583836317,
-0.026523828506469727,
0.0038316291756927967,
0.03324431926012039,
-0.0011224962072446942,
0.013725396245718002,
0.014452220872044563,
0.0036578234285116196,
-0.005861997604370117,
0.0220364760607481,
0.028440959751605988,
-0.0010329597862437367,
0.010912901721894741,
0.0015655694296583533,
-0.05207855626940727,
-0.010365149937570095,
0.004084437619894743,
0.01643255352973938,
-0.00031074380967766047,
-0.012377084232866764,
-0.02966286614537239,
0.01820221357047558,
0.0029810338746756315,
0.0066625578328967094,
-0.0214360561221838,
0.024585628882050514,
0.007573721930384636,
-0.008321614004671574,
-0.012018938548862934,
0.00886936578899622,
0.007162908092141151,
-0.018023140728473663,
0.01630615070462227,
-0.007673792075365782,
0.005967334378510714,
0.020993640646338463,
0.007347247563302517,
-0.04087071120738983,
-0.021499257534742355,
-0.021889004856348038,
-0.002181790303438902,
0.049971818923950195,
-0.006030536722391844,
-0.02547045797109604,
0.044494301080703735,
0.021267516538500786,
-0.0029810338746756315,
0.00034069898538291454,
-0.0028019610326737165,
0.02667129971086979,
0.03429768979549408,
0.004716459196060896,
0.008748228661715984,
0.027851073071360588,
-0.013072307221591473,
0.003865863662213087,
0.023279450833797455,
-0.02308984473347664,
0.021994341164827347,
-0.01543185394257307,
-0.015674129128456116,
-0.019592661410570145,
0.008527020923793316,
-0.03048449382185936,
-0.032190952450037,
0.007126040291041136,
0.0067415605299174786,
0.06320212781429291,
0.015410786494612694,
-0.0008374282624572515,
0.037942346185445786,
0.009543521329760551,
-0.021952206268906593,
-0.026018209755420685,
0.00529581168666482,
-0.031158650293946266,
-0.02584967203438282,
-0.009706794284284115,
-0.004766494035720825,
0.013767531141638756,
0.00965939275920391,
0.020561760291457176,
-0.019687464460730553,
0.02454349398612976,
0.00679422914981842,
-0.027703600004315376,
-0.006441350560635328,
-0.019213447347283363,
0.0009658075869083405,
-0.012356016784906387,
-0.001138955121859908,
-0.01131318137049675,
-0.05169934406876564,
0.038763973861932755,
-0.00177229312248528,
0.012935369275510311,
0.021825803443789482,
0.0031206051353365183,
0.024374954402446747,
0.015610926784574986,
0.004247710108757019,
-0.0061148060485720634,
0.0014417986385524273,
-0.05852517485618591,
0.05064597353339195,
-0.015337050892412663,
-0.00643081683665514,
-0.005667124409228563,
-0.02479630336165428,
-0.051867883652448654,
-0.023785067722201347,
0.009938535280525684,
-0.003457683138549328,
0.0009960918687283993,
0.014578624628484249,
-0.017559658735990524,
0.014747164212167263,
0.0007920017233118415,
0.0036683569196611643,
-0.029810339212417603,
-0.00562498951330781,
0.007794929668307304,
0.024101078510284424,
0.013556856662034988,
-0.024269618093967438,
-0.045252725481987,
0.025512592867016792,
-0.02892550826072693,
-0.002270009834319353,
-0.015589859336614609,
0.011702927760779858,
-0.014578624628484249,
-0.013103908859193325,
0.029705001041293144,
0.00893256813287735,
0.005998935550451279,
-0.03501398116350174,
-0.022815968841314316,
-0.011028772220015526,
-0.02311091311275959,
0.031032245606184006,
0.021246450021862984,
0.015389719046652317,
-0.02656596153974533,
-0.01774926483631134,
-0.028167083859443665,
-0.006557221058756113,
-0.044831376522779465,
0.0011047206353396177,
0.0011034038616344333,
0.0023542793933302164,
-0.01553719025105238,
-0.02547045797109604,
-0.02178366854786873,
0.01777033321559429,
-0.0023832470178604126,
0.020087743178009987,
-0.03754206746816635,
-0.018054742366075516,
-0.02074083313345909,
-0.030084215104579926,
0.03775274008512497,
0.008611290715634823,
0.019245048984885216,
-0.03027382120490074,
-0.0006534178392030299,
-0.028778037056326866,
0.0232162494212389,
0.036025214940309525,
0.031011179089546204,
-0.05106732249259949,
-0.021299118176102638,
0.005714525934308767,
0.006962768267840147,
-0.0038948312867432833,
-0.0035788207314908504,
0.031137583777308464,
-0.038195155560970306,
-0.015568791888654232,
0.042345426976680756,
-0.01654842495918274,
0.013493655249476433,
0.009569856338202953,
-0.010670626536011696,
0.0029810338746756315,
-0.0345715656876564,
-0.015631994232535362,
-0.0022094412706792355,
-0.05165720731019974,
-0.001105378963984549,
-0.010043871589004993,
-0.004571620840579271,
0.029494328424334526,
-0.0012712845345959067,
-0.018655162304639816,
-0.002543885726481676,
-0.0063886819407343864,
-0.037120718508958817,
-0.05692405253648758,
0.011587057262659073,
0.004879731219261885,
-0.03206454962491989,
-0.00019355652329977602,
-0.008021404035389423,
0.006978568620979786,
0.027324387803673744,
-0.03278083726763725,
0.012450819835066795,
0.05561787635087967,
0.024374954402446747,
0.02930472232401371,
-0.0031759070698171854,
0.0073735821060836315,
0.01101823803037405,
0.0010086006950587034,
-0.0012258579954504967,
-0.007989802397787571,
0.015526656992733479,
0.022352486848831177,
0.00028210534946992993,
0.03532999008893967,
0.019961340352892876,
0.012229612097144127,
0.011302648112177849,
0.010338814929127693,
-0.018897436559200287,
0.02667129971086979,
-0.039838410913944244,
-0.0220364760607481,
-0.022689564153552055,
-0.005372181069105864,
-0.025280851870775223,
0.014483821578323841,
0.02667129971086979,
-0.011070906184613705,
0.009159042499959469,
0.003976467531174421,
0.043525200337171555,
-0.032359492033720016,
-0.04156593605875969,
0.022436756640672684,
0.02964179962873459,
-0.029157249256968498,
0.011513321660459042,
-0.013114442117512226,
-0.029831405729055405,
-0.007963468320667744,
0.011197310872375965,
0.011629192158579826,
-0.016011206433176994,
0.020193081349134445,
-0.007937134243547916,
0.0077422610484063625,
0.004782294388860464,
0.014389018528163433,
-0.0065519544295966625,
-0.0019526825053617358,
-0.006841630674898624,
0.0027808938175439835,
-0.010296680964529514,
-0.008895699866116047,
-0.032696567475795746,
-0.015421319752931595,
-0.04095498099923134,
0.019350385293364525,
-0.008769296109676361,
0.01689603552222252,
-0.01701190695166588,
-0.002796694403514266,
-0.004416248761117458,
-0.0061938087455928326,
-0.0017683429177850485,
-0.007262978237122297,
-0.007141840644180775,
0.015084241516888142,
-0.002988934051245451,
-0.014367951080203056,
-0.017886202782392502,
-0.02928365394473076,
0.0033470795024186373,
-0.017559658735990524,
-0.03368673473596573,
0.010238745249807835,
0.02833562158048153,
0.005100938491523266,
0.03288617730140686,
0.03250696137547493,
0.007942400872707367,
-0.001105378963984549,
-0.02502804435789585,
0.0019065976375713944,
0.010233478620648384,
0.005061437375843525,
-0.019476789981126785,
-0.0381108857691288,
-0.028061745688319206,
-0.006399215664714575,
-0.039227455854415894,
-0.02879910357296467,
-0.019150245934724808,
0.001817061216570437,
-0.03480330854654312,
0.021720465272665024,
0.0017525424482300878,
-0.00025988585548475385,
0.00018318742513656616,
0.01800207421183586,
-0.058651577681303024,
-0.016980305314064026,
-0.025870738551020622,
0.01543185394257307,
0.016706429421901703,
0.018528757616877556,
0.0030574030242860317,
0.002838829066604376,
-0.00562498951330781,
0.026271019130945206,
-0.01464182697236538,
0.014209945686161518,
0.022099679335951805,
0.008426951244473457,
-0.02405894547700882,
0.02452242746949196,
0.0345294326543808,
-0.03726819157600403,
-0.015358117409050465,
-0.03547746315598488,
-0.003349713049829006,
0.006246477365493774,
-0.03796341270208359,
0.02095150575041771,
0.01761232689023018,
0.00591993285343051,
0.020277351140975952,
0.030800504609942436,
-0.054143160581588745,
0.019697997719049454,
-0.006509819533675909,
-0.004063370171934366,
0.0010652192868292332,
-0.014252080582082272,
-0.03726819157600403,
0.00753158750012517,
0.0030547697097063065,
0.007679058704525232,
0.02633422054350376,
-0.00473489286378026,
0.008821964263916016,
-0.026228884235024452,
-0.006272811442613602,
-0.02690304070711136,
-0.01655895821750164,
0.007937134243547916,
-0.024353887885808945,
0.01917131245136261,
0.013419918715953827,
0.00529581168666482,
0.033412858843803406,
0.013967670500278473,
-0.018054742366075516,
-0.029599664732813835,
-0.011302648112177849,
0.014547023922204971,
-0.0060674045234918594,
-0.00026696317945607007,
0.10070206224918365,
-0.010986637324094772,
-0.032338425517082214,
0.010301947593688965,
-0.012650960125029087,
-0.023532260209321976,
0.025196582078933716,
0.022373555228114128,
0.032338425517082214,
-0.007410449907183647,
-0.015684662386775017,
0.0020606527104973793,
0.04177660867571831,
0.032212018966674805,
0.0464746318757534,
-0.00798453576862812,
0.00851648673415184,
0.026608096435666084,
0.02479630336165428,
-0.016411487013101578,
0.0014931503683328629,
0.0061464072205126286,
0.012766830623149872,
0.004671690985560417,
-0.05144653469324112,
0.015315983444452286,
-0.01441008597612381,
-0.013209245167672634,
-0.0003936965949833393,
-0.005493318662047386,
0.02097257412970066,
0.0027361256070435047,
0.02774573490023613,
-0.002715058159083128,
0.009032637812197208,
-0.04571620747447014,
0.002007984323427081,
-0.012977504171431065,
0.014157277531921864,
-0.005082504823803902,
0.010496820323169231,
0.012598291039466858,
0.0032101415563374758,
-0.015094775706529617,
0.00917484238743782,
0.005235243123024702,
-0.012292814441025257,
-0.0006165499798953533,
0.0007689592894166708,
-0.04664317145943642,
-0.015094775706529617,
0.0015603025676682591,
0.0038526966236531734,
-0.030337022617459297,
-0.04849710315465927,
-0.009016836993396282,
0.02285810373723507,
-0.007183975540101528,
0.027450792491436005,
-0.03273870423436165,
-0.008595489896833897,
0.031116515398025513,
0.029957810416817665,
-0.0028783304151147604,
0.018897436559200287
] | 2024-06-27 | 66 | 38928301 | [
"solid tumors",
"solid tumor treatment",
"T cell exhaustion",
"combination therapies",
"CAR-T cell therapy",
"gynecological cancer",
"gynecological cancers",
"prolonged cancer remission",
"CAR-T therapy",
"possible approaches",
"blood cancers",
"comprehensive research",
"stromal barrier",
"CAR-T combination",
"many limitations",
"checkpoint inhibitors",
"CAR-T efficacy",
"CAR-T",
"oncolytic virotherapy",
"strategies",
"chemotherapy",
"insights",
"the novel approach",
"a comprehensive overview",
"gynecology",
"This review paper",
"a promising way",
"the current landscape",
"this review",
"the limitations"
] | [
"CAR-T",
"chemotherapy",
"gynecological cancer",
"immunotherapy",
"p53"
] | 0 | 10.3390/ijms25126595
10.1002/cncr.32500
10.1038/s41392-020-0199-6
10.1038/s41577-020-0306-5
10.1200/JCO.2021.39.15_suppl.7508
10.1016/s0140-6736(20)31366-0
10.1172/jci145459
10.1056/nejmoa2024850
10.1016/s0140-6736(21)01222-8
10.3390/immuno3010004
10.1038/s41467-023-41282-x
10.1016/j.trecan.2022.12.008
10.2217/imt-2018-0141
10.3389/fimmu.2023.1185618
10.1038/s41586-019-1324-y
10.1002/advs.202103508
10.1038/s41586-022-05105-1
10.1038/s41392-023-01708-w
10.1093/stmcls/sxac036
10.1002/hep.31792
10.3390/cancers14030819
10.1016/j.bbagen.2022.130095
10.18632/oncotarget.26196
10.1136/jitc-2020-001875
10.1593/neo.04316
10.1080/2162402x.2017.1364827
10.1146/annurev-immunol-032712-095951
10.1158/1078-0432.ccr-13-0458
10.18632/oncotarget.9114
10.1016/j.lfs.2021.119150
10.1182/blood.2022016101
10.3389/fimmu.2022.757480
10.1136/jitc-2021-003737
10.1016/j.intimp.2023.109774
10.7150/jca.22532
10.1093/annonc/mdz135
10.1001/jamaoncol.2020.5945
10.1016/j.matdes.2022.110738
10.1016/s1470-2045(21)00695-1
10.3390/vaccines8040575
10.3390/ph16111610
10.1186/s13062-021-00307-5
10.21037/tcr.2016.08.40
10.1038/onc.2016.258
10.18632/oncotarget.4584
10.1038/s41467-018-06953-0
10.3390/biom13010159
10.1038/s41573-022-00571-8
10.1002/msj.20143
10.1200/jco.2014.58.1967
10.1080/2162402X.2018.1434464
10.3389/fimmu.2023.1140541
10.1126/scitranslmed.aaf8621
10.1002/ajh.25951
10.1038/bjc.2013.415
10.3389/fonc.2023.1159802
10.1172/jci.insight.99573
10.1158/1078-0432.ccr-17-0285
10.1080/2162402x.2017.1395997
10.1200/jco.2017.75.8219
10.1016/j.mayocp.2014.04.003
10.1158/2326-6066.cir-17-0314
10.1016/j.cellimm.2020.104041
10.1016/j.ymthe.2017.09.010
10.1016/j.ymthe.2020.10.023
10.1089/hum.2005.16.765
10.1089/hum.2006.167
10.1038/s41467-020-17011-z
10.1186/s12967-023-04779-z | [
"Olifirenko",
"Barlev"
] | [
"Department of Biomedical Studies, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan.",
"Department of Biomedical Studies, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan."
] | [
"38928301",
"31967680",
"32728057",
"32433532",
"32888407",
"34396987",
"33626253",
"34097852",
"37714830",
"36681605",
"30678555",
"37287982",
"31207604",
"35032108",
"35978192",
"38143263",
"35583414",
"33682185",
"35159087",
"35077823",
"30410677",
"33833049",
"15548365",
"29308299",
"23298206",
"23873688",
"27145284",
"33662426",
"36696633",
"36081498",
"35110357",
"37012881",
"30123362",
"31046082",
"33211063",
"34973215",
"33019641",
"38004475",
"34749806",
"30613473",
"27452519",
"26317544",
"30361475",
"36671544",
"36216888",
"20014427",
"25534375",
"29872570",
"36949946",
"27605551",
"32744738",
"23907428",
"37197423",
"29618658",
"28536305",
"29399394",
"29432077",
"24835528",
"29588319",
"31983398",
"28974431",
"33130314",
"15960607",
"17725410",
"32581235",
"38221609"
] | [] | 9.774804 | 4.653959 |
Subsets and Splits