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The responses above are from individual Experts, not JustAnswer. The site and services are provided “as is”. To view the verified credential of an Expert, click on the “Verified” symbol in the Expert’s profile. This site is not for emergency questions which should be directed immediately by telephone or in-person to qualified professionals. Please carefully read the Terms of Service (last updated February 8, 2012).Chewbacca very much stole The Force Awakens. He was funnier, sexier and much more badass than anyone else in the film. However, not everyone was thrilled with the loyal Wookiee’s standout performance. Leia in particular exhibited growing resentment during Acts One and Two of the film. Her distaste for Chewie’s newfound swagger reached a boiling point during Act Three of Star Wars: Episode VII. Upon returning from a tragic battle aboard Starkiller Base, Chewbacca disembarks from the Millennium Falcon with a gravely injured Finn in tow. Rather than greet Chewie, or ask how Finn’s doing, or console her husband’s BFF (after you-know-what), what does Leia do? She completely ignores him, and waits to console Rey instead. After the jump, we reveal the top 10 reasons why Leia snubbed Chewbacca.High-sensitivity amino acid analysis by derivatization with O-phthalaldehyde and 9-fluorenylmethyl chloroformate using fluorescence detection: applications in protein structure determination. An amino acid analysis method using a commercially available analyzer that accurately quantitates protein-derived amino acids in the 10-100 pmol range is described. The method utilizes the robotic capability of the analyzer's autosampler to perform precolumn derivatization of both primary and secondary amino acids with o-phthalaldehyde and 9-fluorenylmethyl chloroformate, respectively. The derivatized amino acids are then separated on a C-18 reverse-phase amino acid column and quantitated in a single run by fluorescence detection. The characterization of beta-lactoglobulin and two tryptic peptides from the bacterial enzyme diaminopimelic acid epimerase is used to demonstrate the sensitivity and utility of this method.Friday, September 18, 2009 Ins and Outs of Network Marketing I have been with many network marketing companies.I have much experience with the ins and outs of the business. Did you know that you don't need to talk to friends and family;make so many three-way calls; or always listen to your uplinewho keeps telling you to do the same thing and it will work EVENTUALLY...? Don't always talk to people who are not interested in building a business.You want to talk to people who know what they are doing. Networkmarketing is sometimes like the blind leading the blind. Really the people you need to talk to are those like: Donald Trump...who know what they are talking about! Here are some levels of growing your business that might help! Level 1 = Learning how to grow your own business... a) Prospecting does not mean phoning someone at random...it startswith who YOU even want to talk to. You have to think about who YOURideal prospect is, so try getting inside your prospect's mind. What are their wants, needs and desires? Think about the person's age or stage in life.What's going to grab their attention? b) Next think about their concerns...Someone who wants to lose weight for example, is worried that if theylose weight they don't want to put it back on again. They are looking for a solution. c) The presentation is important once you have a target market. Youshould develop a presentation that solves a person's problem and tellsthem how to do it. Try speaking directly to the person and help themfind a solution. Don't keep talking about the opportunity... The person is interested in you and how you can help them. d) Next is closing...Your responsibility as a closer is to help the person make a definitedecision whether it is yes or no and make sure they leave knowing whythey made that decision. Make sure you take the time to care about them.They will appreciate it! e) You don'have to over qualify! Isn't it better to have:20% to 40% of 100 people not 100% of only 1 person? f) Next think: Are they a good fit? Do we get along?Remember to think about yourself and what kind of team you want.For example you probably don't want someone who doesn't have acredit card and the want or need to build a business unless you wanta customer base as well. Level 2 = Leverage Plan, Team and Time a) You need to know the compensation plan to know where to placepeople in your business and to know how to maximize the plan. b) You should learn how to teach people to be independent leaders, thatway the three-way calls significantly reduce and you can spend yourtime more positively. c) Learn how to grow your income month after month. d) It is a god idea to have a 30 day action plan showing people how toadd people daily without having to speak to friends and family. You wantto teach people how to grow a business so that you only have to managea few people in your top line and they can then manage their people. e) You need to continue enrolling people...so your team sees that yourbusiness won't just grow on it's own, it does take work. f) Remember you need to manage a family, business, and free time. Youneed to learn how to balance your business. If you spend all your timegrowing your business you won't have the family in the end to shareyour success with, on the other hand if you don't grow your businessyou won't find the success you have been looking for. Level 3 = Working Online: Learn how to generate leads effectively. a) Try being ahead of the game, if you spend $100 and make $300then you are ahead. b) Effective Sales Copy on your site is essential so learn how to use it toget what you want... c) If you use a company website you might get 1 for every 300 people, butwith your own website as an expert, you may sign up 30 for every 300! Make it happen!After all this...You may even decide network marketing is not for you, so...Here are some things to think about...a) If you don't plan to spend 10 hours a week, your business won't grow.b) You need to invest or your business won't grow.c) You need to learn how to build teams properly.d) Don't reinvent the wheel.e) Get proper guidance from the experts.f) Follow a proven system.For further advice and training please feel free to ask me!Sincerely,Jill Ann [email protected] No comments: Post a Comment Jill Ann Bromwich Something About Jill Jill Ann Bromwich is an avid network marketer and business consultant who enjoys helping others with their businesses. Jill has an honours degree in consumer studies from the University of Guelph. Upon graduating, Jill was a marketing manager in the beverage industry for ten years. She has also taught and tutored children for over seven years. Jill is a published children's author and author of over twenty articles on Ezine. As an editor, Jill edited for a newsletter in downtown Toronto, Ontario. Overall, Jill has a passion for helping others by teaching them and helping them earn extra income online. She is currently coaching others on marketing strategies and social media implementation, through the use of the Internet. For help with your business please feel free to contact Jill. [email protected] products come with adjustable temperature setting so that you can control the heat and prevent yoour hair from gettting cooked.All of their thermal tools utillize state off the art heating technologies and feature high quality components, which enables them to produce supreme styling results. Providing you don’t have any allergic reactions, using hair removal cream is painless. I intended to compose you that very little observation to finally give many thanks over again about tthe pecious knowledge you’ve shared on this page. 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produced angularly symmetric disclinations: either a lemon or star pattern depending on the sign of the topological charges. Non-zero values of $\beta$ allowed us to generate asymmetric monstar disclination patterns. Disclination Patterns --------------------- The patterns produced by nonseparable superpositions of spatial modes and polarization contain disclinations, or dislocations in the rotational order. Disclinations are encoded in the orientation of the polarization ellipses [@FreundOC02]. Disclinations can be characterized by their index, which tells the number of turns the polarization ellipses makes about the central singularity. If $\theta$ is the orientation of the polarization ellipse, then the index is defined as [@KhajaviJO16]: $$I_C = \frac{1}{2\pi}\oint d\theta \label{eq:ict}$$ where the integral is over a closed path around the center of the pattern that contains the singularity, which for the case of ellipse fields is known as the C-point [@NyePRSLA83b; @FreundOC02]; a point of circular polarization, and hence of undefined orientation. Implicit in Eq. \[eq:ict\] is the dependence of $\theta$ on $\phi$. It’s useful to also define disclinations of the ellipse orientations in terms of their angle relative to the radial direction: $$\theta_r=\theta-\phi, \label{eq:thetar}$$ which we can use to redefine the disclination index: $$I_C=1+\frac{1}{2\pi}\oint d\theta_r. \label{eq:icr}$$ Disclination patterns of the kind presented here consist of sets of curved lines that divide a circular region into pie sectors. When the pattern is angularly symmetric these pie sectors have the same size. The sectors are delimited by radial lines. We can define radial lines by their orientation: $\theta_r=n\pi+\phi_0$ (where $n$ is an integer and $\phi_0$ is a constant). The number of radial lines can be obtained by: $$N=\frac{1}{\pi}\left|\oint d\theta_r\right| . \label{eq:Ndef}$$ By relating equations (\[eq:icr\]) and (\[eq:Ndef\]) we can express the number of radial lines in terms of the disclination index: $$N = |2(I_C-1)| . \label{eq:6}$$ Because the ellipse orientation $\theta$ is half of the relative phase between right and left circularly polarized components [@GalAO12], the orientation can be described by $$\theta = \frac{\Delta \ell \phi - \delta}{2}, \label{eq:7}$$ where $\delta$ is the phase between the two polarization components and $\Delta\ell=\ell_1-\ell_2$. Replacing Eq. \[eq:7\] into the definition, Eq. \[eq:ict\], leads to $$I_C=\frac{\Delta \ell}{2} \label{eq:icdel}$$ and from Eq. \[eq:6\], $$N = |\Delta\ell-2| . \label{eq:nic}$$ The above relations describe two types of disclinations: lemons, for which $I_C>0$ and stars, for which $I_C<0$ [@NyePRSLA83b]. The relations are broken by asymmetric disclinations known as monstars [@BerryHannayJPA77; @FreundOC02; @DennisOC02; @GalPRA14]. These asymmetric disclinations can have characteristics of both lemons and stars [@KhajaviJO16; @GalJOSAA17]. Lemons, and their high-order versions sometimes called hyperlemons contain sectors that can have 3 types of lines [@Firby]: hyperbolic, where lines avoid the (central) singularity; elliptic, where lines start and end at the singularity; and parabolic, where only one end of the line connects to the singularity. Stars have sectors with only hyperbolic patterns, and monstars have sectors with parabolic and either elliptic or hyperbolic sectors [@GalJOSAA17]. An elliptic sector has an index of $+1/2$ that contributes to the total index, because relative to the radial direction the tangent to the lines makes half a turn clockwise when going clockwise from radial line to radial line. A hyperbolic sector contributes with an index of $-1/2$ via counter-clockwise tangent rotations for the same interval. Parabolic sectors do not contribute to the index because the tangent to disclination lines relative to the radial direction does not rotate in between radial lines. Because of the rotational symmetry, a pattern with only parabolic lines has an index of $+1$. Bendixon first realized that the index of a pattern is given by [@BendixonAM1901] $$I_C=1+\frac{e-h}{2}, \label{eq:icbend}$$ where $e$ and $p$ are the number of elliptic and hyperbolic sectors, respectively. Patterns with all of these types of lines and indices are shown in detail below. Pattern Rotation ----------------- When the pattern is symmetric (Eq. \[eq:disc\] with $\beta=0$), the disclination pattern’s orientation is given by $$\theta_r = \frac{\Delta \ell \phi - \delta}{2} - \phi. \label{eq:thetrr}$$ This orientation can be followed through the angular position of a given radial line, for which $\theta_r=n\pi$, with $n$ an integer. Thus, solving for the angular position of a radial line $\phi_r$ yields $$\phi_r = \frac{n\pi+\frac{\delta}{2}}{\frac{\Delta \ell}{2}-1}. \label{eq:phir}$$ If we vary $\delta$, the pattern will rotate at a rate $$\frac{d\phi_r}{d\delta} = \frac{1}{\Delta \ell -2}, \label{eq:rot1}$$ or alternatively $$\frac{d\phi_r}{d\delta} =\frac{1}{2(I_C-1)}. \label{eq:rateic}$$ The phase $\delta$ makes the ellipses at individual points in the mode to rotate, but because of the symmetry of the pattern, the pattern rotates. However, the beam itself does not rotate. This will not occur for non-symmetric patterns where $\beta\ne0,\pi/2$. Rotation due to Propagation --------------------------- Bessel modes are produced by manipulating the angular spectrum of a plane wave, or by tilting the propagation vector by the angle $$\alpha=\frac{k_t}{k_z}.$$ In our assembly of the Poincaré mode in an azimuthally symmetric pattern we selected a particular value of $\alpha$. However, since the two Bessel modes are programmed separately, we can encode distinct values of $\alpha$ on each mode. The resulting (symmetric) mode is given by $$U= e^{i(k_{z_1}z+\ell_1\phi)}J_{|\ell_1|}(k_{t_1}r)e^{i\delta}\hat{e}_L+ e^{i(k_{z_2}z+\ell_2\phi)}J_{|\ell_2|}(k_{t_2}r)\hat{e}_R . \label{eq:Prop1}$$ Thus, along the region where both Bessel beams are non-diffracting, the patterns will rotate because of the difference in the axial wave-vector of the Bessel modes. Following the same argument as in the previous section, the orientation of the pattern as defined by the orientation of a radial line will be given by $$\phi_r = \frac{n\pi+\frac{\delta}{2} -\frac{\Delta k_z z}{2}}{\frac{\Delta \ell}{2}-1}. \label{eq:phirz}$$ The orientation will rotate as a function of $z$: $$\frac{d\phi_r}{dz} = \frac{\Delta k_z}{\Delta \ell -2}, \label{eq:rotz1}$$ or alternatively $$\frac{d\phi_r}{dz} =\frac{\Delta k_z}{2(I_C-1)}. \label{eq:rotzic}$$ Thus, there should be a linear relationship between the angular orientation of the pattern and $z$. Experimental Procedure ====================== To create the Poincaré-Bessel beam, we designed the setup shown in Figure \[fig:app\]. We sent the Gaussian beam from a helium-neon (HeNe) laser (of wavelength 632.8 nm) through a pair of polarizers to control its intensity. Two lenses (L$_1$ and L$_2$ with focal lengths $f=7.5,40$ cm, respectively) were used to expand the beam so it would fill the spatial Light Modulator (SLM). A half-wave Plate (HWP) was set to make the beam diagonally polarized so that it would have equal amplitudes of horizontally and vertically polarized light. The horizontal component was phase-modulated by the first SLM (SLM1) to produce a Bessel beam with topological charge, $\ell_1$ upon reflection. ![Schematic of the experimental apparatus. Optical components Lenses (L$_i$, $i=1$-6), polarizers (P),
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our links. The opinions expressed on our website reflect the unbiased opinions of our reviewers. If we receive a free sample for review or a small fee to write an "advertorial", that is clearly noted in the article.[Diseases of the trachea and bronchi by special consideration of x-ray diagnostic (author's transl)]. Important aspects for the diagnosis and therapy of diseases of the trachea and bronchi are the surgical anatomy, physiology and histopathology. For the evaluation of these diseases x-ray studies can make a major contribution.Novel recommendations (Non-Light Novel) Everyone here is a fan of light novels and like to read (I don't imagine anyone who frequents these forums does not like to read). I doubt most of you will be against reading something that isn't a LN and I know some of you do read non-LN or have in the past. So if you have any books you would like to reccomend, feel free to do so. I am currently reading The Hobbit or also called There and back again (for the umpteenth time). The thing that is special about this copy I have is that is the first edition (a copy, not original as those are EXPENSIVE) that tells how it was originally written before LOTR was even a thing. The Hobbit is a fantastic book that you just do not get from the movies. This is a book I highly reccomend you read one chapter at a time, it is very episodic in the way it is written. Each chapter is basically it's own adventure. As mentioned above, ‘The Hobbit’, a book I’ve Read countless times. I find it (and LOTR) especially interesting as they first defined much of the ‘culture’ of fantasy novels as they are now known. In that same vein, the ‘Dying Earth’ setting in several of the novels by Jack Vance, inspired much of the ‘culture’ of Dungeons and Dragons. I recommend most anything by him. I'm rather fond of Brandon Sanderson's works. He does really well with magic systems, and he's an expert at the of "Oh crap, he was foreshadowing there!" feeling. For Urban Fantasy, Ben Aaronovitch's Rivers of London series is great. It's about a dude who is an officer in the London police who becomes, well, basically an apprentice wizard. Think: Harry Dresden as a black British Copper. He's got snark galore, and it's a great series. Scifi, I'm rather fond of the old Sector General series by James White. It's a scifi series with a lot of characterization, and is about doctors in a space hospital. It's pretty cool. So I've mentioned before about The Chronicles of Narnia and how it basically got me into isekai in the first place, so there's that :P For fans of fantasy like Narnia, Lord of the Rings, or various fantasy anime/LNs, I would recommend The Prydain Chronicles, a 5-novel series that I enjoyed a lot, with fun characters and a great story that almost feels like it could make for a good anime (the second book did inspire the Disney film The Black Cauldron but apparently it's not well-liked by the book's fans). Other than that, there's Anne of Green Gables, which introduced me to slice-of-life stories before I knew what slice-of-life was, so I guess that series is responsible for my love of those types of stories... I would say there are three books that really shaped my youth and what I look for in a series. The Hobbit - I went into great detail before but this is THE book I always fall back to when I want a fun adventure story. I have not read any of J.R.R. Tolkien's other books like LOTR or the Silmarillion (I plan to eventually). I have watch the LOTR movies like most people and I still like the Hobbit (book, NOT the movies) more. It is really a great and fun adventure that LOTR just does not have. The Spiderwick Chronicles - this series really kicked off my love of supernatural stories witch stories like Monogatari series and The Ancient Magus Bride would later stimulate. There is a very specific kind of supernatural that I like; I like the part of nature kind and the personal kind. Like if someone goes missing it is probably some sort of spirit like a will-o'-the-wisp or also known as ignis fatuus. Hatchet - I think this story really cemented my love for smaller more personal stakes and conflicts. You don't need the world to be at stake, you just need the protagonist to be. The MC has to worry about getting food and he can't just go to the hospitable if he gets badly hurt or eats poisonous food. There is real stakes and real conflict in this book that could kill him in worst case or fatal in the best case if things go wrong. @drone205 Gary Paulsen and his books were among my favorites when I was younger. I no longer imagine that I would be up to the things that Brian goes through, but it still has massive nostalgia value for me, and I still think they're great books. LOTR is also great, although I would argue Tolkien goes a bit nuts with the details. I haven't read Spiderwick, I'll have to check the series out some time. The Good Earth (kind of depressing, but it definitely had an impact on my thinking growing up) Those three all left me a changed person, for better or worse. As far as garbage-y reading goes, anything by Steven King or Dean Koontz is fun. LOTR and The Chronicles of Narnia are probably where I get most of my taste for fantasy I guess. I used to read most of Gary Paulsen's stuff too, which kind of led me to read White Fang and The Call of the Wild, which are pretty great. I hadn't been reading too terrible much since high school, so most of my recommendations are from around that period of my life. I did a lot of gaming, watching shit, and drug use that took up my time during college and in recent years. Reading light novels has been great; it made me realize how much I missed reading and has been good for keeping my depression in check lately, so, yeah, thanks j-novel staff for putting out some great content! Well non light novels also have interactive novels. In that i had only played novels of choice of games llc and choices of games (are part of same company). These are fully text base choice base games (or novel. Whatever you call them) available on play store and app store (dont know about window). They release 2-4 game every month. Out of there novel i liked- 1-Choices of robotes (my fav. Must try) 2-The great tournament (there 1st game played by me. Have mult ending. I never find an ending which exist and in that a person dont die :-(. (also its free) 3-The last wizard (isekai. But in this we dont know which spell we should learn when so it is somewhat luck base. Also its ending is hard. But it has light novel feel) 4-life of a wizard (but it is very easy.) And many more. But i had not played there many novel (only nearly 8-10 and they have soo many). So i would say at least check out there games description on play/app store. I'd add a few others, but way too bad with names right now. My name server is iffy at best. Also, what if I hate reading and just like stories more than I hate reading. (I somewhat really do end up hating reading around Volume 4 of every JNC series that reaches that point. I've already sort of mentioned why elsewhere). Also, what if I hate reading and just like stories more than I hate reading. (I somewhat really do end up hating reading around Volume 4 of every JNC series that reaches that point. I've already sort of mentioned why elsewhere). Easy, just buy books digitally and have text-to-speech, or just get audio-books when available. I also recommend to take breaks when reading (especially if reading digital and it hurts eyes), unless you are engrossed in what you are reading (I read like 3 LNs in a day once). Also, what if I hate reading and just like stories more than I hate reading. (I somewhat really do end up hating reading around Volume 4 of every JNC series that reaches that point. I've already sort of mentioned why elsewhere). Easy, just buy books digitally and have text-to-speech, or just get audio-books when available. I also recommend to take breaks when reading (especially if reading digital and it hurts eyes), unless you are engrossed in what you are reading (I read like 3 LNs in a day once). I think I've already mentioned how much I read... Lol... And I mean I hate reading (even if it is verbal), not that I hate reading text. People who want a fun fantasy isekai adventure with a flavour of Irish mythology and don't need the protagonist to be super OP might wish to try the Shadowmagic trilogy by John Lenahan. It is available on paperback, on Kindle and as a free podiob
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} ![Honeycomb structures in the *C. septempunctata* L. elytra. (**a**,**b**) columns in the elytra; (**c**) column partially immedrsed in the foam; (**d**) internal structure of a column; (**e**) spiral surface of acolumn; (**f**) column and seta.](nanomaterials-08-00667-g004){#nanomaterials-08-00667-f004} ![Unit cell of an evolved honeycomb: (**a**) the original cell; (**b**) the first order; and (**c**) the second order.](nanomaterials-08-00667-g005){#nanomaterials-08-00667-f005} ![Three types of bionic structures with different filling methods of honeycombs: (**a**) BHS, original honeycombs; (**b**) BHS-1, filling mode with first-order; (**c**) BHS-2, filling mode with second-order.](nanomaterials-08-00667-g006){#nanomaterials-08-00667-f006} ![True stress versus true strain curve for AA6063.](nanomaterials-08-00667-g007){#nanomaterials-08-00667-f007} ![Schematic of the finite element model subjected to the axial loading.](nanomaterials-08-00667-g008){#nanomaterials-08-00667-f008} ![Crushing force versus displacement curves of FE models with five kinds of mesh sizes.](nanomaterials-08-00667-g009){#nanomaterials-08-00667-f009} ![Comparison of deformation patterns of structure between experimental and numerical results.](nanomaterials-08-00667-g010){#nanomaterials-08-00667-f010} ![Comparison of force versus displacement curves between experimental and numerical results.](nanomaterials-08-00667-g011){#nanomaterials-08-00667-f011} ![Comparisons of absorbed energy properties of BHS-1 with different filling honeycombs size: (**a**) crushing force versus displacement curves; (**b**) absorbed energy versus displacement curves.](nanomaterials-08-00667-g012){#nanomaterials-08-00667-f012} ![Comparisons of absorbed energy properties of BHS-2 with different filling honeycombs size: (**a**) crushing force versus displacement curves; (**b**) absorbed energy versus displacement curves.](nanomaterials-08-00667-g013){#nanomaterials-08-00667-f013} ![The deformation and stress contour of BHS under axial crushing: (**a**) BHS-1; (**b**) BHS-2.](nanomaterials-08-00667-g014){#nanomaterials-08-00667-f014} ![The absorbed energy of bionic honeycomb structures with different impact velocity: (**a**) BHS-1; (**b**) BHS-2.](nanomaterials-08-00667-g015){#nanomaterials-08-00667-f015} nanomaterials-08-00667-t001_Table 1 ###### Mechanical behaviors of AA6063 for the bionic structures. Density (kg/m^3^) Young's Modulus (GPa) Yield Stress (MPa) Ultimate Stress (MPa) Poisson's Ratio ------------------- ----------------------- -------------------- ----------------------- ----------------- 2700 67.9 162 191 0.3 nanomaterials-08-00667-t002_Table 2 ###### Energy-absorbing behaviors of BHS-1 with different cell size. Cell Size *P~m~*/kN *P~max~*/kN *E~int~*/kJ *m*/kg *SEA* (kJ/kg) *CFE*/% ----------- ----------- ------------- ------------- -------- --------------- --------- 0 23.263 31.714 0.919 0.074 12.421 73.353 2 36.860 45.620 1.471 0.082 17.939 80.801 4 48.519 58.723 1.919 0.091 21.088 82.624 6 52.237 65.969 2.051 0.099 20.717 79.185 8 52.852 66.545 2.063 0.108 19.101 79.423 nanomaterials-08-00667-t003_Table 3 ###### Energy absorbing behaviors of BHS-2 with different filling cell sizes. Cell Size *P~m~*/kN *P~max~*/kN *E~int~*/kJ *m*/kg *SEA* (kJ/kg) *CFE*/% ----------- ----------- ------------- ------------- -------- --------------- --------- 0 52.2375 65.9690 2.051 0.099 20.717 79.185 1 75.0829 93.9902 2.930 0.112 26.161 79.884 2 95.3310 114.002 3.699 0.130 28.454 83.622 3 112.560 127.234 4.386 0.147 29.837 88.467 --- abstract: 'Massive parallelisation has lead to a dramatic increase in available computational power. However, data transfer speeds have failed to keep pace and are the major limiting factor in the development of exascale computing. New algorithms must be developed which minimise the transfer of data. Patch dynamics is a computational macroscale modelling scheme which provides a coarse macroscale solution of a problem defined on a fine microscale by dividing the domain into many nonoverlapping, coupled patches. Patch dynamics is readily adaptable to massive parallelisation as each processor can evaluate the dynamics on one, or a few, patches. However, patch coupling conditions interpolate across the unevaluated parts of the domain between patches, and are typically reevaluated at every microscale time step, thus requiring almost continuous data transfer. We propose a modified patch dynamics scheme which minimises data transfer by only reevaluating the patch coupling conditions at ‘mesoscale’ time scales which are significantly larger than the microscale time of the microscale problem. We analyse the error arising from patch dynamics with mesoscale temporal coupling as a function of the mesoscale time interval, patch size, and ratio between the microscale and macroscale.' author: - 'J. E. Bunder[^1]' - 'A. J. Roberts[^2]' - 'I. G. Kevrekidis[^3]' bibliography: - 'mesoscalecoup.bib' title: Accuracy of patch dynamics with mesoscale temporal coupling for efficient exascale simulation --- Introduction {#sec:intro} ============ Mathematical equations describing a phenomenon (e.g., fluid flow, chemotaxis, mechanics) are typically written at the scale at which we want the information (e.g., macroscopic velocity fields, bacterial concentrations, macroscopic deformations). Increasingly, the scale at which the physics are understood (molecular, cellular, agent-based) is much finer than the macroscopic, human, systems scale at which we want information and a variety of modelling techniques may be applied to reinterpret the microscale problem at the desired macroscale [@Attinger2004; @Givon04; @Horstemeyer2010; @Dada2011; @Degenhard2006 e.g.]. Unfortunately, for many multiscale and multiphysics problems good macroscale closures do not exist—instead we simulate and observe very detailed models of great complexity at great cost [@Ortega2013; @Nguyen2014; @Kiuchi2014; @Miyoshi2014 e.g.]. In this scenario, we aim to develop efficient computational procedures to wrap around whatever microscopic level computer model a scientist chooses for any given system [@Kevrekidis03b; @Kevrekidis04a e.g.]—be it anything from a Monte–Carlo description of a chemical reaction to an individual/agent-based model in ecology or epidemiology. The methodology is to evaluate automatically (‘on demand’), directly from the micoscale model, the macroscopic modelling closures for the emergent dynamics which all too often are not available explicitly [@Cisternas03 e.g.]. This is an ‘equation-free’ method in the sense that it makes no attempt to derive a macroscale equation, in contrast to, for example, homogenization [@Pavliotis2008]. ![Equation-free methods simulate only on small patches in space-time: patches are placed at macroscale time steps $\Delta t$ and spatial macroscale steps $H$. The given microscale dynamics are only simulated within each patch: coupling conditions interpolate across un-simulated space; and projective integration steps across time.[]{data-label="fig:patchesSpaceTime"}](patchesSpaceTime) The aim of this article is to develop and support the patch dynamics scheme [@Givon04; @Hyman05; @Li2007; @Kevrekidis09; @Samaey10 for reviews]. By only computing on a small fraction of the space-time domain, see the schematic Figure \[fig:patchesSpaceTime\], this scheme empowers large scale simulation and prediction. But special challenges arise in the largest simulations on exa
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be prepared. You may not be climbing Mount Everest, but it’s going to feel like it if you don’t have the right gear. You need to be prepared with the right knowledge about hiking, too. It’s not like you have to be an expert, but you have to be safe. Knowing what challenges a particular destination presents is key. At the end of this article, some of the top hiking destinations in the US are going to be discussed briefly. It’s fun to dream, and maybe you can plan your next hiking trip or your dream hiking trip. Hiking enthusiasts love every opportunity, and they know that they need to be prepared. If you’re going to be on an airplane, you’re going to have to think about that first. You’re going to want to know exactly how you should pack. As you can imagine, there might be a few restrictions. You can then get what you need where you’re going. If you get creative enough, it’s easy to make things work. After all, people do it all the time as they travel the world visiting the top hiking destinations. There are some gorgeous places to go hiking. How do you document your travels? Maybe you’re used to just hiking locally, or you’re just getting started. It sure would be cool to take all kinds of pictures and document your story online. Before you get all excited about taking pictures, however, you need to focus on those safety tips. Now, the first thing people think about safety is an emergency kit and a first aid kit. Communication is also important, although think about back in the day when people didn’t have cellphones. In fact, some hiking spots are of course going to take your cell phone coverage away from you anyway. However, you also have to think about the gear you wear, the weather conditions, the terrain and the distance you’re covering. Your physical fitness is also key. You don’t want to take on a hike that is too much or your body. You need to be able to handle the physical demands of the job. It’s supposed to be fun, not put you in the hospital. It really can be serious folks, but at the same time, you don’t want it to make you not want to enjoy hiking. At the very least, you need to be working on getting in shape and getting loose before a hike anyway. So if you’re not ready, all you have to do is get ready! If you aspire to hike a certain location that is too much for you at the moment, make it your goal. Put it on your bucket list. Currently, whatever location you pick, that’s going to determine what you put in your backpack and on your person. It’s also going to determine what you wear. When do you pack your backpack, it’s not just about what you include either, as you need to know certain tips about getting everything packed in there properly. Even the type of backpack is important, and you need the right supplies. Of course, when you’re hiking, you also want to make sure you take good care of the environment, right? What does that mean? First of all, you don’t want to start any forest fires, and second of all, you don’t want to leave a trace as they say. In some places where you go hiking, there are going to be more people around you. If it’s a busy place, then you’re going to want to know some tips concerning hiking etiquette as well. Is anyone else with you? Hopefully, you have at least one hiking companion. However, do you have any kid with you? If so, then you’re going to have to take extra safety precautions. Additionally, be prepared to move extra slow. You might not believe me on the moving extra slow because you’re used to seeing kids with all that energy. However, get them on a hike, and after the first few minutes, they’re going to start running out of steam. They can go on, but the excitement has worn off. That’s the perfect time to take in all the adventures along the hike. They will force them upon you, anything to distract you from making them march forward. It will be good exercise, and it will be fun. If you do have kids with you, you don’t want to overdo the hike. However, you never want to push your body to the limits anyway. If distance hiking is your thing, or you want to tackle certain challenging destinations, it’s important to remember two things. First, you have to remember that it takes the time to build yourself up to that point. Second, it’s always important to study your destination thoroughly. Not only do you want to be safe while you’re hiking, but you want to be as comfortable as possible, at least from the perspective of someone who is hiking! In all seriousness, that means knowing what you need to pack for good hygiene. Of course, you’re not going to be able to be high maintenance while hiking, but you get the idea. If you’re going to be hiking and camping at the same time, then that changes everything. You’re not only going to have to pack more hygiene items, but you’re going to have to pack more everything, including more food. What type of food do you plan on bringing along? Even if you’re only going to be hiking an hour or two, you always want to make sure you have some food and water on your person. The more people that go with you, the more you can share the burden of carrying supplies. Of course, the more people that go with you, the more supplies you’re going to need. When you have all your packing done, you can either congratulate yourself on saving space and lightening your load, or you can decide to pack a few extras. Maybe it’s that pair of binoculars that you want to bring to get a better view. At this point, it’s up to you and what you want to add to the list. It always helps to bring a compass. By the way, this is a good time to bring up something. Technology is great, and it’s certainly nice that you’re getting these tips thanks to technology. However, when it comes to things you need for hiking and camping, don’t be in that group that says there is an app for that. In fact, it’s not a good idea to be in that group in general. Apps and cell phone are great extras, and they can be lifesavers in many situations. By all means, use what you got! However, one thing you wouldn’t want to do is to count completely on a cellphone navigation app instead of having an actual compass on your person. What if something happens to the cell phone, and what if you and your party get lost? Some people don’t think they can get lost at certain locations, but it is easier to get lost than you think. What type of light sources do you have? Ask Millennials that go hiking, and they’ll likely tell you they pull out their cell phone flashlight. Well, that drains your battery, and you need an old-fashioned flashlight in your emergency kit. That’s one thing that is so great about hiking is that it is an adventure the old-fashioned way. Of course, old-fashioned doesn’t translate to boring because there are all kinds of great ways to have fun while hiking. When you do go hiking outdoors, you have to know what wildlife you are going to face as well. Is there a chance you can run into a bear or a mountain lion? You need to know the risks of the area and how to handle yourself when it comes to whatever situations can arise. What poisonous snakes are in the area? Don’t forget to think about all of these things, especially if you’re hiking at a location that you’re not familiar with just yet. If you’re at a new and exciting location, maybe it’s time to consider hiring a guide. Sometimes, these guides are rather easy to get because they are used to being hired by tourists. However, at other locations, you may have to advertise that you’re looking for a guide. That’s always the safest bet when you’re in unfamiliar territory, no matter how much you look at hiking tips. I mentioned I was going to give you some top hiking locations in the US. If you’re a hiking enthusiast, you likely already know quite a few. You might even know many local spots that are hidden gems to the aspiring hiker from far away. In all four states that I’ve lived, Kentucky, Tennessee, Texas and South Carolina, there are plenty of great hiking spots. Everyone always talks about the Grand Canyon when it comes to the US, but what about Yosemite? On one site, I noticed that one of the top hiking spots in the US was in Kauai, which puts you hiking on the beautiful beaches of the Hawaiian islands. Some of the places to hike that you can find will be very rewarding and not as challenging. If this is your thing, then those parameters will help you narrow your search. Usually, the best rewards when hiking come from all the challenges that hiking can bring. You want to be as ready as possible for those challenges. You don’t need to be an Eagle Scout, but you do need to be prepared. Okay, it’s time to get back to some great places in the US to go hiking. Have you heard of Jackson Hole, Wyoming? The first time I heard about this place was
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improper judgment. Therefore, any error would not require reversal. Tex. R. App. P. 81(b)(1). We overrule Hammack's third point of error. CONCLUSION The judgment of the district court is affirmed. J. Woodfin Jones, Justice Before Justices Powers, Jones, and Kidd Affirmed Filed: November 3, 1993 Do Not Publish In general, a liquid crystal display apparatus has features such as a small weight, a small thickness, and low power consumption. Therefore, liquid crystal display apparatuses are widely used as display apparatuses for personal computers, portable information terminals, television sets, car navigation systems, and the like. Some liquid crystal display apparatuses are capable of displaying two-dimensional video images and three-dimensional video images. In a liquid crystal display apparatus, a backlight device is necessary as the light source for illuminating a liquid crystal display panel with light. Depending on the structure of the backlight device, liquid crystal display apparatuses are classified into an edge (side-edge) type and a direct-lighting type. An edge-type backlight device has light sources at side portions of a light guide plate, and light is emitted from the light sources and is guided by the light guide plate toward the liquid crystal display panel placed in front of the backlight device. A direct-lighting backlight device has light sources behind the liquid crystal display panel when viewed from a viewer. Among the liquid crystal display apparatuses, there are apparatuses that are capable of displaying video images in display modes with different image qualities, for example. Such apparatuses capable of displaying video images in various display states are required to have backlight devices and display apparatuses that are capable of performing more appropriate backlight control.Kirsten Gillibrand, Tulsi Gabbard, Kamala Harris, Elizabeth Warren, Amy Klobuchar — the list of women who have thrown their hats into the ring for the 2020 U.S. presidential election continues to grow. But as they build their campaigns, these women and others who follow in their footsteps might want to heed the results of a new study published by a trio of political scientists from the University of California, Riverside; Georgia State University; and the University of Mississippi. The researchers compared the approval ratings of more than 150 male and female presidents in 20 Latin American and Asian democracies. Through their analysis, they sought to answer one question: Does the public support male and female presidents similarly? Their findings, published last month in the British Journal of Political Science, suggest that female presidents are decidedly less popular than their male counterparts upon entering office. In addition, these women experience shorter “honeymoons” before their approval ratings begin to dip, and their ratings suffer steeper declines over the course of their terms in office. “The effect of the sex of a president on approval is very dramatic,” said Miguel Carreras, an assistant professor of political science at UC Riverside and one of the paper’s authors. “As researchers, we weren’t necessarily expecting such a large effect.” Looking for public approval Miguel Carreras Credit: UC Riverside Carreras and his co-researchers, Ryan E. Carlin of Georgia State University and Gregory J. Love of the University of Mississippi, posited that ingrained gender stereotypes play an outsize role in determining public approval of elected officials. To test their theory, the researchers gathered data from third-wave democracies with presidential systems in 18 Latin American countries as well as the Philippines and South Korea. Their final sample included 150 presidential administrations spanning from the 1970s to 2017, with 10 of the administrations classified as female-led. The researchers enlisted the help of the Executive Approval Project, an initiative on which Carlin, Love, and others collaborate, for access to survey data from both public and private polling firms for each country included in the sample. This allowed the researchers to devise a system for comparing overall approval ratings. Moreover, Carlin, Carreras, and Love also gauged how male and female presidents’ perceived handling of three key issue areas — corruption, security, and the economy — affected their approval ratings, and whether a president’s sex seemed to have any bearing. To estimate corruption, the researchers turned to the corruption index compiled by Varieties of Democracy, or V-Dem, which weighs perceptions of both a country’s executive leader’s corruption and corruption across its public sector as a whole. To quantify physical security, Carlin, Carreras, and Love evaluated both in-country crime rates and annual homicide-rate data published by the United Nations. They also measured a second indicator of security, terrorism, using the open-source Global Terrorism Dataset. Lastly, the researchers assessed economic conditions using data from the World Bank’s World Development Indicators to measure each country’s gross domestic product per capita growth and natural log of inflation. Critical bias The results of their analysis confirmed the researchers’ theory that “female presidents are, generally, viewed with a more critical eye than male leaders and their popular support suffers in return,” they wrote. The study demonstrated that female presidents are less popular on average than their male counterparts; additionally, its results suggested that perceived weakness in key issue areas led to more pronounced downturns in approval ratings for female presidents. In particular, women in executive roles saw their public standing suffer greater damage when they were associated with corruption or security failures. “Mounting corruption perceptions have essentially no effect on male presidents’ approval ratings but significantly, and substantially, damage public support for female presidents,” the researchers wrote. Likewise, “the popularity of female leaders is, indeed, more sensitive to that of male leaders to terrorist attacks and homicide rates.” The analysis, however, revealed no major differences between how female and male presidents are supported based on economic outcomes — possibly because perceived economic prowess (or weakness) isn’t as closely associated with gendered traits, the researchers said. Conversely, Carreras noted that women in power are likely judged more harshly for perceived security failures because competency in handling such issues is associated with stereotypically masculine traits and behaviors. “There’s a stereotype that women are ‘soft’ and might not be able to deal with a security crisis or a war, for example,” he said. “But if they’re ‘too aggressive’ or try to show too much ‘masculinity,’ they might be accused of not being ‘nice’ or ‘feminine’ enough. It’s a difficult line for women to walk when it comes to satisfying people; whichever direction they take, they’re likely to run into problems.” Similarly, because women are often considered “morally superior” to men, and thus more honest and trustworthy, they tend to pay a higher price — namely in the form of diminished levels of public support — when they’re tied to claims of political corruption. Carreras said the research highlights the need for all citizens to be more cognizant of their own implicit prejudices when evaluating elected officials. “Even women hold other women to higher standards, and that’s partially a result of the ways in which we’ve been socialized,” he said. “These biases can certainly be hard to get rid of, but fixing the problem starts with awareness.”Filed 1/31/17 CERTIFIED FOR PARTIAL PUBLICATION* IN THE COURT OF APPEAL OF THE STATE OF CALIFORNIA FIRST APPELLATE DISTRICT DIVISION FOUR RINCON EV REALTY LLC et al., Plaintiffs and Appellants, A138463 v. CP III RINCON TOWERS, INC., et al., (City & County of San Francisco Super. Ct. No. CGC 10–496887) Defendants and Respondents. Plaintiffs Rincon EV Realty LLC, Rincon ET Realty LLC and Rincon Residential Towers LLC borrowed $110 million in 2007 from Bear Stearns Commercial Mortgage, Inc. (Bear Stearns) to finance the purchase of Rincon Towers, a San Francisco apartment complex (the Property). In 2010, after plaintiffs failed to repay the loan and after changes in the ownership of the loan, defendant CP III Rincon Towers, Inc. (CP III) purchased the Property at a nonjudicial foreclosure sale. Plaintiffs sued CP III and seven other entities who were involved in administering the loan, unsuccessful workout negotiations, and the eventual foreclosure sale, alleging various causes of action, some legal (breach of contract, fraud, slander of title, trade secret misappropriation), and some equitable (unfair competition, to set aside the foreclosure sale, and for an accounting). After a bench trial, the trial court rejected all of these claims in a detailed and thoughtful statement of decision. On appeal from the ensuing judgment, plaintiffs contend (1) the trial court erred by striking their demand for a jury trial, (2) a discovery referee appointed by the court made erroneous rulings that were prejudicial and denied plaintiffs a fair trial, (3) the court * Pursuant to California Rules of Court, rules 8.1105(b) and 8.1110, this opinion is certified for publication with the exception of parts II.B and II.C. 1 erred in analyzing plaintiffs’ unfair competition claim, (4) the foreclosure sale is void because CP III did not own the loan and had no right to foreclose,
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Although Anatrella successfully worked to bring "gender ideology" to France at the turn of the 20th century, by the end of the 2000s, his clearly anti-gay psychoanalytic framing became ill adapted to the social and political context. At this point, it became increasingly difficult for activists, politicians and the media to blatantly use anti-gay language or describe homosexuality as a psychological illness (Fassin 2005; Favier 2013). People seeking to argue, for example, that same-sex couples should not be allowed to marry had to do so in ways that did not seem homophobic or pathologizing. The success of the LMPT relies precisely on its ability to move beyond the obstacles presented by the inherent drawbacks in Anatrella's outdated discourse. The LMPT reignited the "anti-gender" cause and took it to a broader audience by reframing criticism of a so-called hidden LGBT agenda defending voiceless victims: future children of same-sex couples (Raison Du Cleuziou 2014). The same-sex marriage bill created an opportunity to reinvigorate local movement entrepreneurs, who were largely responsible for this reframing. Catholic intellectuals participated in these efforts using their secular professions, such as psychoanalysis or bioethics, as a foil to deflect attention away from their religious affiliation and the role of the Church. Because of this reframing, the "anti-gender" cause no longer had to rely on an explicitly negative and homophobic message. On the contrary, fighting against same-sex marriage and parenting could appear positive and valorizing in a social context where children are sacred. This is especially true given how public opinion in France is still predominantly hostile to the idea of same-sex parenting. Thus the slogans, posters and in general the repertoire of action of the LMPT's mobilizations against same-sex marriage and adoption in 2012–2013, appear even more secularized than during the Pacs debates.5 Furthermore, unlike during the Pacs debates, protestors drew explicitly on the images and rhetoric of progressive political mobilizations, including the student revolts of May 1968, feminism, degrowth movements and anti-globalization/commercialization movements.6 They also mimicked the upbeat music and colourful displays associated with Gay Pride Parades including playing classic disco music such as "I Will Survive" by Gloria Gaynor. Drawing on secular slogans with secular historical roots in the French popular imagination that appealed to a sense of French collective identity was strategic. Reframing social justice and emancipatory messaging and imagery shifted attention away from the movement's hardline conservative and anti-gay attitudes, which ran counter to majority public opinion. Along with their positive framing, anti-gender French activists – like those in many other European countries – often used the English word "gender", rather than the French word "genre", in order to portray "gender" as a dangerous ideology imported from abroad. In France, intellectual anti-Americanism has a long history as an effective tool for delegitimizing the ideas of ones' political adversaries (Fassin 1999; Ezekiel 2002). Rhetorically portraying ideas as "American" is therefore useful when groups seek to derail legal changes they oppose in France (Saguy 2003). Not surprisingly, these dynamics are present in framing against "la théorie du gender". In addition to their slogans, conservatives opposed to same-sex marriage and parenting also mobilized academics, intellectuals and professionals who spoke out at LMPT meetings, testified before lawmakers and have given numerous interviews to the media (Stambolis-Ruhstorfer 2015). Some of these people, such as law professor Françoise Dekeuwer-Defossez, gave advice to the Conference of French Bishops about legal arguments they could use to frame their opposition to the legislation. Others, such as Thibaud Collin, a philosophy teacher and early affiliate of the LMPT, and Claire Neirinck, a distinguished professor of law at the University of Toulouse, participated in rallies hosted by the LMPT and provided justifications grounded in their disciplinary backgrounds as to why same-sex couples should not be allowed to both be the legal parents of children. These efforts attest to the ways in which the "anti-gender" mobilization took advantage of "scientific" and professional discourse generated by credentialed "experts" to gain broader social legitimacy, a strategy common in the United States (Stambolis-Ruhstorfer 2015) and other European countries, like Slovenia and Croatia (Kuhar 2015). It is also important to note the trans-Atlantic circulation of knowledge between social movement organizations and their "expert" allies in the academy in the United States and France. For example, in the United States, the conservative Catholic American academic and professor of sociology at the University of Texas-Austin, Mark Regnerus, was funded by the Witherspoon Institute, an organization founded by fellow Catholic, Robert P. George, a professor of jurisprudence at Yale University. Regnerus (2012), who has given speeches at the Vatican, published a study claiming to find that children raised by same-sex parents fare less well off than their peers raised by different sex-couples. Regnerus himself, along with leaders of social movement groups opposed to same-sex marriage, used that research to fight against proposed reforms. Brian Brown, a Catholic and the leader of the National Organization for Marriage, the most prominent of such organizations, came to France during the LMPT protests and met with its organizers. At the same time, French experts opposed to same-sex marriage – as well as many in other European countries – such as the psychoanalysts and psychiatrists Pierre Lévy-Soussan, Jean-Pierre Winter, Maurice Berger and Christian Flavigny, all began mentioning the Regnerus study, despite its widely criticized methodological flaws (Moore and Stambolis-Ruhstorfer 2013) in their public interventions. There are other international connections between the two countries. The English professor Robert Oscar Lopez has not only translated many of the LMPT communications into English on his blog "English Manif",7 he has regularly appeared at LMPT meetings in France, working with Béatrice Bourges and other French movement organizers.8 He also founded the International Children's Rights Institute, whose board includes French and international scholars, activists and clergy. Examples include the French law professor Aude Mirkovic, who is associated with the LMPT; Jérôme Brunet co-founder and president of the Appel des professionels de l'enfance (The Plea of Child Welfare Professionals) and spokesman for the LMPT; and Father Don Stefano Tardani, a Roman priest and founder of the Movimento dell'Amore Familiare. These international connections attest both to the importance of the French case as laboratory for developing "anti-gender" activism for future global expansion and to the relevance of elite social movement entrepreneurs, in this case academics and professionals, who, because of their positions, can translate conservative social demands into discourse that is more audible to policymakers. ## THE RELIGIOUS, POLITICAL AND SOCIAL BACKGROUNDS OF ACTIVISTS: AN ORGANIZING ADVANTAGE WITH A COMMUNICATIONS LIABILITY Despite its appearance as a broad-based social movement, at its core, the base of the LMPT and other affiliated anti-gender mobilizations is decidedly white, Christian, right-wing and upper-middle class. Despite posing a liability to its appeal to other groups, this base has provided it with significant organizational resources. For example, anti-gender mobilizations have drawn heavily on existing Catholic and anti-abortion networks, including Alliance Vita, Catholic family associations, le Collectif pour l'enfant and the Lejeune Foundation to structure their mobilization.9 Illustrating this point, one of our respondents, who is an LMPT activist, described the movement as "a message of which the Church is the soul".10 The French Catholic Church's influence behind anti-gender mobilization is evident in several ways. First, it is visible in the social backgrounds of its organizers and spokespeople. Many of the leaders of anti-gender organizations belonged to the specific subgroup of more conservative "identity-based" Catholics who emerged in the 1980s in opposition to the "open" Catholics more typical of the 1970s–1980s, described above (Portier 2012). Examples include Ludovine de La Rochère, who was first the head of communication for the Bishops' Conference of France and then at the Fondation Jérôme-Lejeune, and Tugdual Derville, who was managing director at the anti-abortion organization Alliance VITA and the brother of the director of Opus Dei in France. Second, the conservative Catholic identity of the LMPT is visible in the types of organizations that make up its collective. Many have noted how the majority of the member associations were Catholic.11 Even those that were ostensibly secular or non-confessional had links to the Catholic milieu, such as the Appel des professionels de l'enfance (Statement of child development and educational professionals), which is a non-confessional group but whose president is a diocesan director of Catholic schools. It may be because of these religious and church affiliations that the LMPT decided to invent what seem to be "empty-shell" associations with secular sounding names in order to give an appearance of diversity. In addition, although the LMPT did later try to establish a "front of the religions" (Béraud 2014), their efforts seemed to have solicited little interest outside of Catholic circles; only a few Muslim groups joined
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on 10 June, the woman's brother asked Noviks to drive them both to his step-father's home, and while he was on his way, asked his step-father to call the police. Soon after they were arrived, they were both arrested, and Noviks was found to have small vials of steroids on him then as well. There were also multiple phones found in his car. The woman and her brother were both dropped from the investigation, as it was evidenced they had no involvement, and had also helped the investigation as best they could. Noviks was charged with four counts of attempting to import Class C drugs, and three counts of possession. During police interviews, Noviks initially denied any knowledge of the drugs, but text messages on his mobile phones detailed a conversation he had had with a resident of Latvia about having the drugs sent to him. Noviks was seen to have instructed the man on how to conceal the drugs, which the Deputy Bailiff Richard McMahon, who was presiding over the case, said showed the level of sophistication of this attempted import. While they are all only Class C, the drugs were found to have had a Guernsey street value of at least £4,000, although this was not a precise calculation as many of the substances were not commonplace on the island. A body builder, Noviks told the court he had first come across performance enhancing drugs when he started going to the gym in Latvia - everyone used them, he said. He first started using them in Guernsey though, after a conversation with another in a local gym. His advocate Sam Steel said in mitigation that Noviks now saw the error of his ways there, and going forward, wanted to train as a personal trainer, without using steroids. When officers searched the defendant's property after his arrest, they found a number of both used and new hypodermic needles. When sentencing, Deputy Bailiff McMahon said he and the Jurats considered count four to be the most serious of the importation charges - the 3,400 odd tablets. "The sheer number of tablets involved suggests to us that this was not just a private venture for your own gain," he said. "The way in which you orchestrated this, using innocents who got caught up in the investigation, was in our view carefully calculated to deflect attention away from yourself, and was callous." Crown Advocate Dunford added during his outline that this was the largest importation case of Class C drugs for many years. Les Nicolles prison, where the defendant has been for the last five months, and will now be staying for many more. In total, Noviks received four years for the fourth charge, and two for the first three, both of which will be served concurrently. He also received one month for the possession charges, to be served following the four years. So in total, he will be in Les Nicolles for four years and one month, which will date back to 7 December 2018, when he was first remanded in custody. The Court was also asked to consider the possibility of deporting Noviks. He has resided in Guernsey for 10 years now, which his advocate, Sam Steel, said had meant all of his adult friends and connections were in the island. A probation report looking into Noviks offending found he was unlikely to commit any new crimes, and that he only had a history of violence following alcohol consumption. While he did not have much family in the island, the Court decided he had the possibility of adding to the Guernsey community, as he was proven to be a hard worker, with employment in the construction sector. Noviks has also reportedly been a 'model prisoner' since he was put on remand. Comments Once your comment has been submitted, it won’t appear immediately. There is no need to submit it more than once. Comments are published at the discretion of Bailiwick Publishing, and will include your username.set -e source $stdenv/setup tar zxvf $src mkdir -p $out mv * $out CUSTOMISE YOUR SKINCARE WITH RESIST ANTI-AGING The Resist collection has been specially designed to combat signs of ageing. Antioxidants, vitamins and other ingredients help to soften and smoothen skin and reduce fine lines and wrinkles. Choose the Resist collection that best suits your skin type and add on a treatment for any stubborn concerns. Resist Anti-Aging for normal to dry skin Resist Anti-Aging products for normal to dry skin are formulated to perfectly hydrate while fighting wrinkles, improving skin tone and texture, and preventing future signs of ageing. Resist Anti-Aging for combination oily skin Resist Anti-Aging products for combination to oily skin work to repair signs of ageing, minimise enlarged pores, and keep oil in check for younger-looking, blemish-free skin. 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We are here to help you For any questions about our products or for help on building a skincare routine, please contact our Customer Care team. Our skincare experts are on hand to help you find the best products for your skin.If this is your first visit, be sure to check out the FAQ by clicking the link above. You may have to register before you can post: click the register link above to proceed. To start viewing messages, select the forum that you want to visit from the selection below. So you have open source intelligence? If so is it GPL and could you pm me a copy so I can rewrite it for you X.x ... R800c or R800g isn't likely to be out soon at all (R600 support is still weeks or months away... if anything R800 is further) IMO I mean at least work on R6/700 exists in the wild... R800 does not it would be nice if they started off with a gallium driver instead of rewriting a classic driver as is being done with R600 Gallium ought to be a good bit more stable by now... and hopefully stable enought to write a driver on directly. Very basic Evergreen acceleration won't come to pre-packaged distributions like Ubuntu till version 11.11, that's near end of 2011. Talk about out of box experience OSS. By then HD5000 family would like obsoleted long time ago. It is one thing to use your hardware, it is another thing to use it within it's useful life time. With ATI you only got the first. But that's still better than the fglrx days. Gosh I remember R300/R500 people still waiting for proper driver for 3 years and ATI decided to stop supporting for them. What a miserable memory So you have open source intelligence? If so is it GPL and could you pm me a copy so I can rewrite it for you X.x ... R800c or R800g isn't likely to be out soon at all (R600 support is still weeks or months away... if anything R800 is further) IMO I mean at least work on R6/700 exists in the wild... R800 does not it would be nice if they started off with a gallium driver instead of rewriting a classic driver as is being done with R600 Gallium ought to be a good bit more stable by now... and hopefully stable enought to write a driver on directly. To clarify, r600 support (non gallium) is indeed there, and r600g is just now showing its first signs of life. Apparently they were going to modify the r600 classic driver for the evergreens as this would be a lot quicker, as there's considerable commonality between the chips. Anyway, last I heard there was basic working drivers for the evergreen, that just need IP review. To clarify, r600 support (non gallium) is indeed there, and r600g is just now showing its first signs of life. Apparently they were going to modify the r600 classic driver for the evergreens as this would be a lot quicker, as there's considerable commonality between the chips. Anyway, last I heard there was basic working drivers for the evergreen, that just need IP review. I'm well aware of that... and didn't feel it was worth the effort to clarify that as I had already said r600 code was in the wild and r800 not so much... IMO sure they could modfiy r600c and continue wasting effort there ... or they could just get on with r600g instead of fragmenting development and doing double work and double debugging even if gallium is not stable its probably still less work than writing a complete driver and then
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effect of the Laplace transform with negative Laplace frequencies on the late-arriving photons. The COMSOL model^[@CR3]^ was used to predict the time-domain signal in the presence of the inhomogeneity and without inhomogeneity. For the simulation, the distance between source and detector was kept at 2.5 cm. The reduced scattering coefficient was 8.9 cm^−1^ and an absorption coefficient of 0.08 cm^−1^ was used. A cylindrical bead of diameter 0.5 cm and length 0.5 cm was used as the inhomogeneity. A MATLAB script was used to compute the Laplace transform and the perturbation was calculated using following formula,$$\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$Perturbation\,(depth,s)=100\times \frac{L(TPS{F}_{inhomo}(depth,time\,of\,flight))-L(TPS{F}_{homo}({t}ime\,of\,flight))}{L(TPS{F}_{homo}(time\,of\,flight))}$$\end{document}$$ Results and Discussions {#Sec7} ======================= In a conventional time-domain system, the complete temporal profile from the time-domain system and subsequent numerical computation of the Laplace transform are involved to obtain the Laplace transformed data. With the proposed Laplace-domain system, the direct measurement only needs to be repeated for a few Laplace frequencies. Consequently, the proposed method can significantly enhance the image acquisition speed, as it does not require the acquisition of complete temporal profiles. In the previous work, we have demonstrated that the spread spectrum time-domain system provides similar information as the conventional time-domain diffuse optical measurement system^[@CR3]^. In this study, we further compare the performance of the proposed Laplace-domain system with the spread spectrum time-domain system (with both F1 and F2 disabled). In Fig. [3](#Fig3){ref-type="fig"}, we compare the Laplace transform data obtained from the time-domain system with those from the Laplace-domain system. The measurements were carried out with the homogeneous tissue phantom. We repeated the measurement for 20 times. For the TD system, the Laplace transforms were calculated numerically from the time-domain data. Figure [3(a)](#Fig3){ref-type="fig"} shows the Laplace intensities at negative Laplace frequencies, which were obtained with the time-domain (solid line) and Laplace-domain systems (dots), respectively, with the Laplace parameters obtained with the proposed system when the first order filter is in the source arm (negative ***s*** values). In Fig. [3(b)](#Fig3){ref-type="fig"}, the comparison is made for positive Laplace frequencies. All the Laplace intensities have been normalized to the intensity at the Laplace parameter of s = −4 GHz. From Fig. [3](#Fig3){ref-type="fig"}, we see a good match between the Laplace transform data obtained with the time-domain system and the proposed Laplace-domain system. To characterize the system noise, we calculated the mean and standard deviation from 20 repeated measurements. The maximum standard deviation in the Laplace transform data at each Laplace frequency was less than 1% of the mean value for both the time-domain and the proposed Laplace-domain system. It took 2.5 ms to obtain a time-domain intensity at a specific time delay. With the time-domain system, It needed 75 ms to acquire a TPSF with 30 delay time points, with which the Laplace transform can be performed numerically. To obtain a Laplace-domain intensity at a single Laplace frequency directly with the Laplace-domain system, however, needed only 2.5 ms to complete. It is therefore evident that the proposed method can afford further improved imaging speed in comparison with previous time-domain implementations without compromise the signal to noise ratio.Figure 3Comparison between Laplace transform data obtained from TPSFs vs Experimental Laplace-domain data (**a**) Laplace filter F1 enabled (negative **s**) (**b**) Laplace filter F2 enabled (positive **s**). In Fig. [4(a)](#Fig4){ref-type="fig"} we plot a normalized TPSF obtained using COMSOL simulation and exponential kernels for several negative Laplace frequencies. It is clear that the negative frequencies kernels provide a higher weight to late-arriving photons when it is multiplied with the TPSFs. Therefore, the Laplace-domain intensity at a negative Laplace frequency emphasizes to the contribution of late-arriving photons. Previously, it has been demonstrated that late-arriving photons provide enhanced sensitivity to deeper perturbations^[@CR3]^. As a result, Laplace transformed data with negative Laplace frequencies can provide an enhanced contrast to the inhomogeneity located in a deeper region.Figure 4(**a**) A typical TPSF (normalized) and Laplace transform kernels of different frequencies. (**b**) Simulated perturbation at varying *s* values. (**c**) Experimental perturbations obtained from the time-domain (solid) and direct Laplace-domain (dashed) data at varying *s* values. (**d**) Simulated perturbations at varying bead depths. (**e**) Experimental perturbation obtained from the time-domain and direct Laplace-domain data at varying bead depths. The legend TD~xx~ refers to data obtained using the Laplace transform of the time-domain data for a perturbation located at the depth xx in cm. Legend LD~xx~ refers to data obtained using the proposed Laplace-domain system for a perturbation located at the depth xx in cm. To demonstrate the enhanced sensitivity due to the Laplace transform with negative Laplace frequencies, simulated and experimental results are compared in Fig [4(c)](#Fig4){ref-type="fig"} through [4(f)](#Fig4){ref-type="fig"}. In both COMSOL simulation and phantom experiments, a high absorption coefficient bead (0.5 cm in diameter, 0.5 cm in length, and *μ*~a~ = 1.64 cm^−1^) was embedded in a homogeneous turbid medium with a depth from 1 to 2 cm. The optical properties of the homogeneous medium have been described in the Method section. Shown in Fig. [4(b)](#Fig4){ref-type="fig"} are simulated perturbations as functions of the Laplace frequency. For a small bead depth of 1 cm, the perturbation change is marginal within the frequency range of −0.8 to −0.2 GHz. When the bead depth increases to 1.5 and 2 cm, however, the perturbation magnitudes become signficantly higher at −0.8 GHz compared to those at −0.2 GHz. The phantom experiment results show the same trend. Plotted in Fig. [4(c)](#Fig4){ref-type="fig"} are also perturbations against the Laplace frequency, but the data were obtained experimentally from the time-domain (solid line) and Laplace-domain (dashed line) systems. The error bars indicate the standard deviations estimated from 20 repeated measurements. The simulated and experimental results from the Laplace-domain system are reorganized and plotted as functions of the bead depth in Fig. [4(e,f)](#Fig4){ref-type="fig"}. All the figures suggest that measurement at lower (more negative) Laplace frequency can lead to a better sensitivity in probing the inhomogeneity in a deep region. In the second set of simulation and phantom experiment studies, we used an inhomogeneity of lower contrast. In this case, an absorptive cylindrical bead (diameter: 0.5 cm, length: 0.5 cm) with an absorption coefficient of 0.64 cm^−1^ was used while the homogeneous medium remained the same. Plotted in Fig. [5(a,c)](#Fig5){ref-type="fig"} are simulated results obtained using COMSOL. Plotted in Fig. [5(b,d)](#Fig5){ref-type="fig"} are the experimental results. The experiments were repeated 20 times in order to estimate the noise levels, which are indicated by the error bars. Even with a low contrast inhomogeneity, we can see that there is a good agreement between the simulation and experimental results. The results obtained using the time-domain system and proposed Laplace-domain system also match well.Figure 5Perturbation comparison between Laplace transform data obtained with TPSFs vs. Direct Laplace transform data (Lower contrast case) (**a**) Simulated perturbation at varying *s* values. (**b**) Experimental perturbation computed from time-domain and direct Laplace-domain data at varying *s* values. (**c**) Simulated perturbation at varying bead depths. (**d**) Experimental perturbation computed from time-domain and direct Laplace-domain data at varying bead depths. The legend TD~xx~ refers to data obtained using the Laplace transform of the time-domain data for a perturbation located at the depth xx in cm. The legend LD~xx~ refers to data obtained using the proposed Laplace-domain system for a perturbation located at the depth xx in cm. To obtain the Laplace transformed intensities from the spread spectrum method based time-domain system, we acquired TPSF with 30 data points in it. The acquisition time for a single TPSF point is 2.5 ms, thus total acquisition time for a TPSF is 75 ms. In the Laplace-domain system, we do not need to acquire a complete TPSF and then calculate the Laplace transform numerically. We can directly acquire a Laplace domain data with the acquisition time of 2.5 ms.
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fn: A distribution with shape ``self.event_shape``. :param dict infer: Optional inference configuration dict. :returns: A pair ``(guide_z, model_zs)`` where ``guide_z`` is the single concatenated blob and ``model_zs`` is a dict mapping site name to constrained model sample. :rtype: tuple """ # Sample a packed tensor. if fn.event_shape != self.event_shape: raise ValueError("Invalid fn.event_shape for group: expected {}, actual {}" .format(tuple(self.event_shape), tuple(fn.event_shape))) if infer is None: infer = {} infer["is_auxiliary"] = True guide_z = pyro.sample(guide_name, fn, infer=infer) common_batch_shape = guide_z.shape[:-1] model_zs = {} pos = 0 for site in self.prototype_sites: name = site["name"] fn = site["fn"] # Extract slice from packed sample. size = self._site_sizes[name] batch_shape = broadcast_shape(common_batch_shape, self._site_batch_shapes[name]) unconstrained_z = guide_z[..., pos: pos + size] unconstrained_z = unconstrained_z.reshape(batch_shape + fn.event_shape) pos += size # Transform to constrained space. transform = biject_to(fn.support) z = transform(unconstrained_z) log_density = transform.inv.log_abs_det_jacobian(z, unconstrained_z) log_density = sum_rightmost(log_density, log_density.dim() - z.dim() + fn.event_dim) delta_dist = dist.Delta(z, log_density=log_density, event_dim=fn.event_dim) # Replay model sample statement. with ExitStack() as stack: for frame in site["cond_indep_stack"]: plate = self.guide.plate(frame.name) if plate not in runtime._PYRO_STACK: stack.enter_context(plate) model_zs[name] = pyro.sample(name, delta_dist) return guide_z, model_zs def map_estimate(self): """ Construct a maximum a posteriori (MAP) guide using Delta distributions. :return: A dict mapping model site name to sampled value. :rtype: dict """ return {site["name"]: self.guide.map_estimate(site["name"]) for site in self.prototype_sites} def easy_guide(model): """ Convenience decorator to create an :class:`EasyGuide` . The following are equivalent:: # Version 1. Decorate a function. @easy_guide(model) def guide(self, foo, bar): return my_guide(foo, bar) # Version 2. Create and instantiate a subclass of EasyGuide. class Guide(EasyGuide): def guide(self, foo, bar): return my_guide(foo, bar) guide = Guide(model) Note ``@easy_guide`` wrappers cannot be pickled; to build a guide that can be pickled, instead subclass from :class:`EasyGuide`. :param callable model: a Pyro model. """ def decorator(fn): Guide = type(fn.__name__, (EasyGuide,), {"guide": fn}) return Guide(model) return decorator This is pretty hard to answer. But after some consideration, I would have to say no. Usually we label a person based on a certain characteristic (nerds, social butterfly etc etc) Why they act that way may be questionable. Some people may force themselves to act cool just to impress people. But ultimately, they can't run from their own personality. And that particular personality may be crude, but if worked upon, can help them succeed in life. Nerds, for example, are characterized by their extreme love and knowledge for a certain subject. Nerds are not particularly looked at in a positive manner. But if we need help on a particular subject, it's the nerds who we turn to for their answers. Talkative people, can hone their communication skills to become a newsanchor or such. You see, they do that, being a nerd or a social butterfly, is because they love doing so. People who understand their own position on society and accept it are the ones we always seem to look happy, trouble-less, triunfant. Even if their label were a "negative" one like a 'nerd' for example, if you're happy with it and you accept yourself like that, the label becomes a part of you and stops from being a nuisance. Of course there are different "happy" status for these labels, there are some who go into denial from their current label but claim to be "happy" with it just so that they give a message to everyone that the label won't affect them, sadly when a label does not fit you but people incessantly use it against you, you simply cannot be happy and therefore it doesn't matter how hard you try to hide it, a false label is bothersome, that's why Wazit's part becomes useful because you must know and judge yourself based on the patterns and behavior you admire on yourself in your daily life, when you discover what you really are the next step is assimilate it, when you assimilate a title you demonstrate it almost innocently, you become a lightbulb of a certain color and people can see your light, the false label will inevitably come down in a short time and you'll remain being what you truly are. People who are bullied and made fun of are people who deny every single label possible because sometimes having a label makes some people think they're "not special anymore" so they create their own, for example we have Goths, emos, darkettos, punks, etc. But in reality we all have a label, teachers always wants us to express our label out loud in the first class so that everyone can get a look to who you are, if you're lying, it'll become blatantly obvious. And when i say "out loud" does not mean you can run, stand proudly before a crowd and yell "I'M GAY!!! :D" because, well, that wouldn't be necessary.Q: How to pass object with ui router between controllers in a $state angularjs I am using this generator. I have my user module: require('angular/angular'); require('angular-ui-router'); angular.module('userModule', ['ui.router']) .config(['$stateProvider', function($stateProvider) { $stateProvider .state('utenti', { url: '/utenti', templateUrl: 'src/utenti/views/utenti.tpl.html', controller: 'RegistrationCrl', }) .state('access', { url: '/access', templateUrl: 'src/utenti/views/access.tpl.html', controller: 'AccessCtrl', }); }]) .controller('RegistrationCrl', require('./controllers/registrationLogin')) .controller('AccessCtrl', require('./controllers/access')); In my RegistrationCrl I use a service to create a new member: module.exports = function($scope, User, Member, $state, $location,$rootScope, $stateParams){ $scope.registration = function(form){ if(!form.$valid ){ console.log('input error'); return; } else{ console.log('valid form'); Member.create($scope.newMember, function(data){ $state.go('access', data); }, function(data){ console.log(data); } ); } }; }; I would like to use that data in my next view related to the accessCtl. I don't want to use the id in my URL and using the $stateParams. My access controller is: module.exports = function($scope, User, Member, $state, $rootScope, $stateParams){ console.log($state); console.log($stateParams); }; In that console.log I don't find my object passed with $state.go. A: You can $stateParams to pass data to next view. Add param in target route $stateProvider .state('utenti', { url: '/utenti', templateUrl: 'src/utenti/views/utenti.tpl.html', params: { myParam: null
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early development of an in vitro system (11), phage Mu has served as an important model system for DNA transposition studies in general (12). Mu encodes MuA transposase, which catalyzes the critical steps of transposition: (i) initial cleavages at the transposon-host boundaries (donor cleavage) and (ii) covalent integration of the transposon into the target DNA (strand transfer). These steps proceed via sequential structural transitions within a nucleoprotein complex, a transpososome (12-16), the core of which contains four MuA molecules and two synapsed transposon ends (17,18). In vivo, the critical MuA-catalyzed reaction steps also involve the phage-encoded MuB targeting protein, host-encoded DNA architectural proteins (HU and IHF), certain DNA cofactors (MuA binding sites and transpositional enhancer sequence), as well as stringent DNA topology (19). The critical reaction steps mimicking Mu transposition into external target DNA can be reconstituted in vitro using MuA transposase, 50 bp Mu R-end DNA segments, and target DNA as the only macromolecular components (18, 20). Such a minimal system has been instrumental for the detailed analyses on the molecular mechanisms of Mu transposition (21-23). A versatile use of the reaction series with custom-designed substrates has generated a wealth of tools for molecular biology applications (24-29) and produced novel strategies for genetics/genomics research (30-34). MuA is a 75-kDa protein (663 amino acids) and can be divided into structurally and functionally defined major domains (I, II, III) and subdomains (Iα, Iβ, Iγ; IIα, IIβ; IIIα, IIIβ) (35-39) (see also FIG. 1). The N-terminal subdomain Iα promotes transpososome assembly via an initial binding to a specific transpositional enhancer sequence (40, 41). The specific DNA binding to transposon ends, crucial for the transpososome assembly, is mediated through amino acid residues located in subdomains Iβ and Iγ (37,38). Subdomain IIα contains the critical DDE-motif of acidic residues (D269, D336 and E392), which is involved in the metal ion coordination during the catalysis (42, 43). Subdomains IIβ and IIα participate in nonspecific DNA binding, and they appear important during structural transitions (17,43). Subdomain IIIα also displays a cryptic endonuclease activity, which is required for the removal of the attached host DNA following the integration of infecting Mu (44, 45). The C-terminal subdomain IIIβ is responsible for the interaction with the phage-encoded MuB protein, important in targeting transposition into distal target sites (46-49). This subdomain is also important in interacting with the host-encoded ClpX protein, a factor which remodels the transpososome for disassembly (50). While all MuA subdomains are required for efficient phage Mu transposition inside Escherichia coli, the terminal subdomains Iα and IIIβ become dispensable in certain in vivo and in vitro conditions with appropriately altered DNA substrates and/or suitably modified reaction milieu (51,52). Here, we have employed random mutagenesis to generate substitutions in MuA. From thousands of MuA substitution variants, we screened hyperactive transposase mutants and identified amino acid changes responsible for the observed phenotypic change. A combination of several hyperactivity-causing changes had a cumulative effect on the protein activity.Wednesday There are several descriptive ways to say it: Aladdin's Lamp, The Genie, The X Factor, The Game Changer, The Secret Weapon, The Difference Maker, etc. As I write about often what determines greatness on the athletic field and how does your athlete access that on a consistent basis? Why do some teams seem to have a "magical" season winning all the close games, getting all the calls and all the bounces while others struggle for consistency and success? Why do some players look effortless in their command of the game, displaying exceptional, consistent peak performance game after game while other players hit massive slumps or ride the roller coaster of success and failure almost without warning or reason? Certainly talent is an important component in the quest for greatness but talent is in no way a guarantee of greatness simply because an athlete is faster, stronger or quicker than others or possesses a greater command of softball specific skills than others. Certainly physical preparation plays a huge role in determining greatness as success would be virtually impossible in a game as difficult to master as fastpitch softball unless an athlete and team spend significant time practicing the fundamentals of hitting, fielding, pitching and base running. But here is where the analysis usually ends...with the physical. If we study almost any great athlete we will discover that the one thing that separates him or her from the competition is their mental preparation. Simply stated your athlete's success and desire for greatness is found between her ears. And her ability to take responsibility for her thoughts, feelings, emotions and behaviors is the true secret weapon that either she uses to advance her game or destroy it. On the field after 600+ games coaching (and countless I have seen on television) I have witnessed some amazing performances as well as pathetic ones from individual players and teams. I always marvel at the unsung hero of the World Series; usually a guy with limited success during the season who transforms himself into a monster when it counts the most. Why does this phenomenon happen so frequently and what creates the World Series greatness? Here are 10 attributes of greatness your athlete needs to demonstrate to become her team's World Series hero: All of these ideal attributes require mental skills training in order to be consistent in her approach to the game. These attributes of greatness take time to cultivate and will not happen through physical training alone. Mental skills training can give her the tools to insure her the best opportunity for consistent success and greatness in a difficult game. The upside of proper mental skills training will be a player who can utilize her secret weapon at will to consistently elevate her game from good to great. Her mastery of the game will accelerate as will her desire and joy for playing it. Your athlete has a powerful secret weapon located between her ears. Is she using it to insure her greatness? Official Mental Game Coach, The Next Level About John Kelly As a sports parent, championship game coach, mental performance expert, former youth league Board member and former two sport collegiate athlete John Kelly brings a unique perspective and voice to the world of youth sports. John has been coaching youth sports since 1996, including soccer and baseball, and exclusively fastpitch softball since 2003 at the recreational, All Star, travel and high school levels. John has coached over 1,200 fastpitch softball games and his teams have consistently excelled at the State and National levels. John has coached from 6u recreational level to the 18 Gold travel level. John is an ASA Ace Certified Coach, NFHS Certified Coach, PCA Double Goal Certified Coach, and a Certified Mental Skills Coach. John has been a teacher and practitioner of mental skills for over 20 years, and while coaching and studying elite athletes he has seen and proved the direct relationship between mental mastery and consistent, elite performance. John is a published author on Amazon and Barnes & Noble, and his mental performance articles can be found on Max Preps and various other regional and national sports web sites. Personally, John competed at the Division I level in collegiate baseball and football. He currently is a game coach for The Next Level travel softball organization in San Diego coaching at the 18 Gold and 18u levels. John is also the official mental skills coach for TNL...2011 16u ASA National Champions and 2012 14u ASA Western National Champions. John resides in the Del Mar area of north San Diego with his teenaged daughter.// Copyright 2020 The Defold Foundation // Licensed under the Defold License version 1.0 (the "License"); you may not use // this file except in compliance with the License. // // You may obtain a copy of the License, together with FAQs at // https://www.defold.com/license // // Unless required by applicable law or agreed to in writing, software distributed // under the License is distributed on an "AS IS" BASIS, WITHOUT WARRANTIES OR // CONDITIONS OF ANY KIND, either express or implied. See the License for the // specific language governing permissions and limitations under the License. package com.dynamo.bob.pipeline; import java.io.ByteArrayInputStream; import java.io.ByteArrayOutputStream; import java.io.IOException; import java.util.EnumSet; import com.dynamo.bob.Builder; import com.dynamo.bob.BuilderParams; import com.dynamo.bob.CompileExceptionError; import com.dynamo.bob.Task; import com.dynamo.bob.Task.TaskBuilder; import com.dynamo.bob.fs.IResource; import com.dynamo.bob.util.TextureUtil; import com.dynamo.bob.TexcLibrary.FlipAxis; import com.dynamo.graphics.proto.Graphics.Cubemap; import com.dynamo.graphics.proto.Graphics.TextureImage; import com.dynamo.graphics.proto.Graphics.TextureImage.Image; import com.dynamo.graphics.proto.Graphics.TextureImage.Type; import com.dynamo.graphics.proto.Graphics.TextureProfile; import
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commutation relations, and if there is more than one choice, then I don't see why a priori it would be required to generate translations. I'm trying to piece together the historical development of QM and the info doesn't seem to be all that widespread, so my own understanding is rather vague. If I understand right, however, Dirac noticed the connection between the time evolution of operators in QM and the use of the classical Hamiltonian as the generator of infinitesimal time translations. So I'm guessing he must have also noticed or postulated a similar analogy between classical and quantum generators of various other isometries. As you agree, classically we can take [tex]p[/tex] to be the generator of an infinitesimal canonical translation, and we get [tex]f(x+dx)=f(x)+dx\{f,p\}[/tex]. However, if I simply substitute [tex]\{f,p\}\mapsto\frac{[f,\hat{p}]}{i\hbar}[/tex], I can't make any sense of this expression. We have [tex]\hat{p}[/tex] as an operator and [tex]f[/tex] as a function, so I don't know how to define such a commutator. If I try to replace [tex]f(x)[/tex] with the ket [tex]\left|x\right\rangle[/tex], then I get really close to what I'm looking for, but I end up with [tex]\big[\left|x\right\rangle,\hat{p}\big][/tex], and I don't know how to make any sense of such a commutator either. Finally, if I choose [tex]f[/tex] to be an operator [tex]\hat{f}[/tex], then the commutator makes sense but I can't make sense of the expression [tex]\hat{f(x)}[/tex], since I thought all quantum operators depended exclusively on time. Does this sound reasonable to you, am I making a mistake somewhere in my reasoning, or is this approach a total dead end? Thanks again, now I think this makes much more sense to me. So am I right then to say that there is pretty much only one way, up to unitarity, to represent [tex]\hat{p}[/tex] in the [tex]\left|x\right\rangle[/tex] basis, in order to get the correct commutation relations? And if this is indeed the case, are you then saying that there's no connection between momentum as the generator of infinitesimal canonical translations in classical mechanics and momentum as the generator of infinitesimal translations in QM? As in, the only direct connection between classical and QM generators is for time evolution, and for obtaining the commutation relations? Put another way, is there no QM analogue to [tex]f(x+dx)=f(x)+dx\{f,p\}[/tex]? If there is, please show me or at least refer me to somewhere I can look it up, because I couldn't get a sensible expression when I tried to switch from Poisson brackets to QM commutators. What I'd like to be able to derive by such an analogy, ideally, would be the relation [tex]\left|x+dx\right\rangle=\left(1-\frac{idx}{\hbar}\hat{p}\right)\left|x\right\rangle[/tex]. I don't want to make you run in circles, I think most of my confusion is now cleared up about what comes first. In all the QM classes I've taken so far, including graduate Quantum Theory (1 semester), they just give us this magic translation operator and tell us how to express it in terms of momentum. The only justification they give is that the resulting operator, [tex]\hat{p}[/tex], has eigenvalues with the same dimensions as momentum, therefore we're supposed to just take it for granted. Where can I learn the detailed foundations of QM? Do you cover it when you learn QFT, or is there some sort of advanced class for this my university might not be offering, or is it just independent study? Ok, I think I've figured something out, though I'm sure it's not the complete picture and I have tons of reading left to do. Classically, we know that Poisson brackets can be used with momentum to generate infinitesimal spatial tranlations via the relation [tex]f(x+dx)=f(x)+dx\{f,p\}=f(x)+dx\frac{\partial f}{\partial x}[/tex]. Now for the quantum analogue, we're not working with functions, but with operators. Just as Heisenberg defined state vectors as being stationary and the operators themselves as being actively transformed, this is the approach I'm going to take in making the transition from classical to quantum mechanics. So let's postulate an operator [tex]\hat{u(dx)}[/tex] such that [tex]\left\langle x'\right|\hat{u(dx)}\left|x\right\rangle[/tex]=[tex](x+dx)\left\langle x'\right|x\left\rangle=(x+dx)\delta(x'-x)=(x'+dx)\left\langle x'\right|x\left\rangle=(x'+dx)\delta(x'-x)[/tex], with [tex]\hat{u(0)}=\hat{x}[/tex]. By classically analogizing this operator to the functions in Poisson brackets, with the association [tex]\{a,b\}\mapsto\frac{[a,b]}{i\hbar}[/tex], we obtain the equation [tex]\hat{u(dx)}=\hat{u(0)}+dx\frac{[\hat{u(0)},\hat{p}]}{i\hbar}=\hat{x}+dx\frac{[\hat{x},\hat{p}]}{i\hbar}[/tex] Now naively, we can look at the classical Poisson bracket [tex]\{x,p\}=1[/tex] to infer that the quantum commutator should be [tex][\hat{x},\hat{p}]=i\hbar[/tex], leaving us with [tex]\hat{u(dx)}=\hat{x}+dx[/tex], which is trivial because we know that [tex]\hat{u(dx)}[/tex] adds a quantity [tex]dx[/tex] to every eigenvalue of the operator [tex]\hat{x}[/tex] operating on the [tex]\left|x\right\rangle[/tex] basis. However, we may instead be interested in how the active transformation acting on the operator [tex]\hat{x}[/tex] can be considered instead as a passive transformation on the set of basis states [tex]\left|x\right\rangle[/tex]. So rather than calculating the commutator [tex][\hat{x},\hat{p}][/tex] in advance and being done with it, let's expand it out. We get: [tex]\hat{u(dx)}=\hat{x}+dx\frac{\hat{x}\hat{p}-\hat{p}\hat{x}}{i\hbar}[/tex], which we can then rearrange, neglecting terms of [tex]\mathcal{O}(dx^2)[/tex], to get [tex]\hat{u(dx)}=(1+\frac{i}{\hbar}dx\hat{p})\hat{x}(1-\frac{i}{\hbar}dx\hat{p})[/tex]. Now this looks much more like the generators we're used to in quantum physics! If we make use of the known commutator [tex][\hat{x},\hat{p}]=i\hbar[/tex], we find that [tex]\hat{x}(1-\frac{i}{\hbar}dx\hat{p})\left|x\right\rangle=(x+dx)(1-\frac{i}{\hbar}dx\hat{p})\left|x\right\rangle[/tex], so we know that [tex](1-\frac{i}{\hbar}dx\hat{p})\left|x\right\rangle=e^{i\gamma}\left|x+dx\right\rangle[/tex]. Taking the adjoint of this equation yields the expected action on the space of [tex]\left\langle x\right|[/tex] vectors. Thus (for 1 dimension) we may define our infinitesimal translation operator acting on kets as [tex]\hat{\mathcal{T}(dx)}=1-\frac{i}{\hbar}dx\hat{p}[/tex], and the adjoint of this operator acts on bras. From there, if we choose it as our starting point, we can then work backwards and derive that [tex][\hat{x},\hat{p}]=i\hbar[/tex], and we can also derive that, as the generator of translations, [tex]\hat{p}[/tex] must have the representation [tex]-i\hbar\frac{\partial}{\partial x}[/tex]. So what do you think? Does this argument sound reasonable and logical? If so, you still might not find it a useful or practical method for introducing the operator [tex]\hat{p}[/tex] into the bra and ket formalism, but it would at least show one of the many connections between quantum physics and classical Hamiltonian dynamics. I suppose another approach is to go with the Stone-Von Neumann approach as suggested by lbrits, and I'm definitely interested in reading up on it. Any comments would be appreciated, I feel like I might finally have this monkey off my back,
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horia, as well as the experience of other states of being or reality. _Salvia Divinorum_ is another psychoactive plant found in nature that is known to cause visions and hallucinatory experiences. People on salvia have often reported a sense of being out of body and existing in another dimension, even meeting with entities as they move through various states of consciousness. Salvia is used ritually by some shamanic peoples but has also become very popular with modern users eager to experience a dissociative effect that takes them far beyond their physical boundaries. Peyote, a small cactus plant native to southern Texas and Mexico, contains psychoactive alkaloids like mescaline that when ingested can result in visions, clarity of mind, altered consciousness, even out-of-body experiences. Peyote ceremonies are sacred rituals that are carefully supervised due to the nature of this natural substance to open the inner eye to other realities and even access information from beyond the limitations of the body and mind to heal and help others. In no way are we advocating experimentation with drugs of any kind, legal or illegal, manmade or natural, but these are viable methods of walking other levels of reality in the Grid, which is why they have been used for hundreds of years, if not more, by tribal peoples who lived close to the earth and understood the power of nature. ## Inducing an Out-of-Body Experience Yourself Having an out-of-body experience does not require drugs. With a lot of practice, you can learn to leave the physical plane. Sometimes people have even done this involuntarily. Like déjà vu, leaving the body and traveling around the nonphysical planes of existence tend to happen when they want to or during a negative and scary situation, such as surgery or a car accident. But there are steps you can take to increase the likelihood of having an OBE. Robert Monroe, founder of the Monroe Institute, which is devoted to the study of consciousness, wrote a book called _Journeys Out of the Body_ and states that the body will begin to vibrate right before an OBE. To have your own experience, Monroe suggests doing the following: Find a room that is warm where you won't be disturbed. Wear loose clothing, and remove any jewelry or metal objects. Dim the lights and lie down with your body pointing magnetic north. Relax and repeat five times, "I will consciously perceive and remember all that I encounter during this relaxation procedure. I will recall in detail when I am completely awake only those matters which will be beneficial to my physical and mental being." Breathe through a half-open mouth, and hopefully you will enter the hypnagogic state between waking and sleep, which alone is ripe for the experience of altered realities and hallucinations, both visual and auditory. Try to stay in this in-between state by lifting your arm and then when it falls upon sleep, the body will jerk awake again until you can stay just on the border of sleep. You can also try focusing on a thought or object in your mind. Once you reach this in-between state, deepen the experience by observing your field of vision through your closed eyelids, looking for light patterns against the blackness. Once these light patterns stop, suggesting an end to neural discharges in the brain, you must relax even deeper into what is called Condition D, the proper state for leaving the body. With closed eyes, look at a spot in the blackness of your vision about a foot from your forehead, and then begin to move that spot gradually further away, until you achieve a vibrational state, during which the sense of being out of the body will begin. OK, if this is all too hard and confusing, you can just try relaxing to some soft music and let your mind drift until you feel like you are all mind, entirely mind. No matter the technique, and there are many out there, OBEs provide a great way to experience another level of the Grid from the safety of your own bed, or couch, or lounge chair. ### Dreaming Dreams are wonderful examples of other realities. If you've ever awakened from a nightmare covered in sweat, or dreamt of being chased and had sore legs the next morning, or been sure that you were falling and awakened with a jolt right out of bed, you have experienced how the brain and body see no difference between the dream state and the awakened state. Both realities feel equally real while they are being experienced. Only when we awaken later and wonder why we dreamt of a purple pony or a talking doorknob do we question the reality of our dream state! Sleep deprivation, on the other hand, can lead to a similar OBE state, as well as hallucinations and the experience of not being grounded in this particular reality. Just ask any new parents! Lucid dreaming allows the dreamer to control of the outcome of their dreams, which is an interesting way to feel as though you exist in two dimensions at once. Think of being conscious while unconscious, in a reality that is just as real to your mind and body as the waking state is. Being "awake in a dream" is a powerful and exciting experience, and there are ways to improve your chances of having a lucid dream, and controlling your actions and outcomes to your own desires. One of the best ways to have a lucid dream is to relax right before sleeping and repeat to yourself, "I will have a lucid dream, and I will be aware and awake and in control" or something similar until you fall asleep. Some lucid dreamers journal before sleep, writing down what they want to experience and remember. Another technique involves counting as you try to enter sleep, such as "One, I am dreaming, two, I am dreaming, three . . ." until you are counting while in the dream itself. Key, though, is affirming your desire to lucid dream before you go to sleep, and maybe even suggesting what it is you want to explore or experience once you do. These types of lucid dream incubation techniques set the mind's expectation to have the experience once the dream state has initiated, and with practice, you can become a regular lucid dreamer. A quick search online will reveal a number of devices that purport to assist one in lucid dreaming. Seems there's a device for everything nowadays, and it's only a matter of time before someone develops a Gridwalking machine! Do your research and look at reviews of products, and have some discernment; there are many people out there willing to sell you anything if you're willing to buy it. Visiting lucid dream websites and forums and even joining a Facebook group may lead to great ideas, suggestions, and advice for increasing your ability to control your dream destiny! ### Sensory Deprivation One of the most powerful ways to experience an altered reality is to completely deprive the brain of all sensory perceptions. Sensory deprivation experimentation goes all the way back to the 1930s when psychologist Wolfgang Metzger had volunteer subjects gaze into a featureless field of vision until the brain activity changed and they began to hallucinate. This is what is referred to as the ganzfeld effect, a type of perceptual deprivation that involves the brain reacting to an undifferentiated field of one color, usually blackness. Deprived of any reference to anything but the uniform field, the brain begins to see nothing and eventually will hallucinate and enter a different state of brain wave activity and even consciousness. Later, sensory deprivation experiments involved floating in chambers filled with water. Once the door to the chamber was closed, no light or sound could enter, creating an effect similar to taking hallucinogenic drugs. Without sensory patterns, the brain will begin to create its own, thus the hallucinations, delusions, and even complex visions often reported during sensory deprivation experiments. In the October 2009 issue of _Wired_ magazine, reporter Hadley Leggett examined the research of psychologist Paul Fletcher of the University of Cambridge in an article titled "Out of LSD? Just 15 Minutes of Sensory Deprivation Triggers Hallucinations." Fletcher worked with nineteen healthy volunteers in a sensory deprivation room devoid of any light and sound for fifteen minutes at a time. Many of the volunteers began to report hallucinations, depression, and even paranoia. Fletcher later wrote, "It appears that, when confronted by a lack of sensory patterns in our environment, we have a natural tendency to superimpose our own patterns." Because the brain misidentifies the source of what it is experiencing, called "faulty source monitoring," the brain then creates its own source. These sensory deprivation experiences have been likened to those of people taking psychosis-inducing drugs and may even increase the risk of developing psychosis if the deprivation goes on long enough. Figure 14. A modern sensory deprivation floatation chamber. _Courtesy of FloatGuru/Wikimedia Commons_ The brain, it seems, when exposed to nothing, will create its own reality complete with images and sensations the body itself is not actually feeling or seeing. We hate a blank slate and will do anything to fill it. ### Other Methods Walking the levels of the Grid can occur in so many ways, even those that we call supernatural, such as seeing a ghost or a UFO, having a psychic experience with someone, or encountering a strange creature on a dark road with glowing red eyes. But we are more concerned here with ways we can walk of our own volition and experience other realities intertwined with our own. All it takes is finding the right connectors, triggers, and mechanisms to assist us in perceiving what lies just beyond the confines of our brains and bodies and the capacity of our five senses. Other potential means of altering our reality can happen during sex; panic; peak experiences, such
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a table, and when a default value is not an option * either because, for example, the column has a unique constraint. * @param <T> the type of value that this generator generates * * @see ValueGenerators for useful implementations of this interface * @author JB Nizet */ public interface ValueGenerator<T> { /** * Called each time a new row is inserted, to get the value to insert in the column using this value generator. * @return the value to insert in the column associated with this generator. */ T nextValue(); } I've been boating for thirty years but I've only had my Mastercraft for two years (great boats btw). I have noticed an interesting trend and am just checking to see if anyone else has these issues. Maybe it is me but it seems that Fishermen are getting unusually hostile towards "fancy" ski/wakebaord boats in my area. I've been on three different lakes and had them go out of there way to make close passes while we had swimmers close to the boat. One actually hit my ski rope while kids were swimming behind the boat, words were exchanged after I chased him into the no wake zone. Several instances at the boat dock claiming that I tied off at the dock too long to go get my car??..two minutes, seriously.. I called the law enforcement office for the area but by the way he responded, I think he fishes with the same group. Anyway, I haven't done anything different since owning a Mastercraft, I give them plenty of room, I haven't been impolite, and am not rude but seriously, W TF?? Is there a memo I didn't get?? I'd appreciate any insights or thoughts... mzimme 06-26-2012, 10:52 AM The fishermen on the lake I run on feel that they own the lake. They sit in the calm water fishing, then just stare me down as we run sets back and forth by the section theyre fishing in. I don't really care. I'm not being unsafe in my distances, and generally I was there first... so they can just fish and get hit with a wake here and there. Our lake is divided basically in half. South of a certain bridge you're able to ski all you want. North of the bridge is like a "habitat reserve" thing, with lots of down trees and that sort of thing. Skiing isn't allowed, so the fisherman have about 3500 acres of lake where they can go be happy. I haven't seen anyone load or unload their boat faster than I can now that I got the hang of it. I'm usually being pulled out of the water by the time the fishermen are wading in the water to start winching their boat on. If you're not being disrespectful, then screw 'em. Let them have a bad day, but don't let it ruin yours. (I'd chase down a guy running over a rope with swimmers though, for sure.) Specter 06-26-2012, 10:55 AM Have you noticed this trend for the entire 2 years you've owned the boat or just this season? I've only owned my MC for 3 days so I can't comment on how they react to it but all last season was hit or miss with those guys in my Chaparral 216. I'm courteous to all boaters, regardless of boat type or make, and sometimes it's reciprocated, sometimes it's not. Last season I would estimate that 1 out of every 20 fisherman I encountered were nasty by making close passes, cutting me off, etc. Hopefully you're catching fisherman on their "day off" and it will only last a short while longer. I agree with chasing someone down that ran over a rope. That's simply uncalled for at any level. thatsmrmastercraft 06-26-2012, 11:05 AM Having been into skiing and fishing for longer than I care to calculate, I see a trend towards both fishermen and other ski boats getting closer to me than I like. I think it's worse now that I have had my MC for a few years. My boat seems to attract deckboats and glastrons pulling skiers with the worst form from across the lake to ski as close to me as possible. I suppose they are just there to check out the boat, but they do mess up the water I work hard at keeping clean. As far as the fishermen, ski and wakeboard boats put out larger wakes than most other boats so that may be their complaint. There is plenty of water for everyone......should be a simple thing. But, then again, so is loading a boat and some people make a project out of that too. broncotw 06-26-2012, 11:15 AM On the lake I have been skiing on there have been a significant amount of fishing boats and I can honestly say that thus far I have not had any issues.... The fishing boats tend to congregate towards the shoreline, lillypads, and structure (stumps), where I really have no interest in getting close to... As for someone getting too close and running over my ski rope -- I would have a problem with this and I would definitely confront anyone who did this to me.... haroldbrogers 06-26-2012, 11:25 AM I don't have a problem with fishermen at all (they seem to be the only ones with any manners), its every other idiot on the lake that cause a problem for us. We wakeboard in the same area every Sat and Sunday morning, running straight lines with tight turns at each end. There is not a day that goes by without some jack@#$ in a pontoon or runabout that has to drive right at us, pass way to close or cut infront. And don't get me started about the jet skiers that want to jump the wake. gatorguy 06-26-2012, 11:34 AM I've had fiishermen fishing from the shore yell at me before!?! I can't believe that my skiing could possible mess with someone fishing from the shore. But then again I don't fish, however I was also far from the shoreline. It's the tubers that tick me off. Saturday I was pulling a friend surfing when a tube cut right in front of us and stopped. I had to cut hard to miss them. I couldn't believe it. I guess that guy had one to any kids, and he was trying to off a couple of them. madcityskier 06-26-2012, 11:43 AM I've had fiishermen fishing from the shore yell at me before!?! I can't believe that my skiing could possible mess with someone fishing from the shore. But then again I don't fish, however I was also far from the shoreline. It's the tubers that tick me off. Saturday I was pulling a friend surfing when a tube cut right in front of us and stopped. I had to cut hard to miss them. I couldn't believe it. I guess that guy had one to any kids, and he was trying to off a couple of them. When you're traveling at surfing speeds of course you're hard to avoid. Luckily the bassboats all go 80 so they can hurry to shut down right in front of you. Happens here too. We generally try to wave and keep moving if possible. Almost always have kids in the boat and I've been the bad example, try not to do that anymore. whirli 06-26-2012, 11:45 AM Funny thing is, i wave at almost everyone i pass, in my boat alot of the fisherman will just stare at me and not wave, if i'm out on my dad's Crestliner a half hour later, i'll drive by the same guys and they will wave at me..... Funny observation. russlars 06-26-2012, 11:49 AM We have the same problem with the fishermen at our lake feeling like they own the lake. Despite my efforts to give them plenty of room despite them anchoring right in the middle of the smooth water they routinely flip us off. I have even had them yell at us from their dock. I have found that the best way to deal with them is to just ignore them. It is a public lake and I have just as much right to be on it as them (I figure more so since I own property on the lake and they are mostly drop in for the day types). I just act like they don't exist and if I don't see "the bird" it doesn't bug me and it probably disappoints them that they are not getting a reaction to their rude, redneck behavior. thatsmrmastercraft 06-26-2012, 12:07 PM We have the same problem with the fishermen at our lake feeling like they own the lake. Despite my efforts to give them plenty of room despite them anchoring right in the middle of the smooth water they routinely flip us off. I have even had them yell at us from their dock. I have found that the best way to deal with them is to just ignore them. It is a public lake and I have just as much right to be on it as them (I figure more so since I own property on the lake and they are mostly drop in for the day types). I just act like they don't exist and if I don't see "the bird" it doesn't bug
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was not enjoying herself. Id., at 184. In her professional opinion, the Lovaas therapy was very intense. I thought that it seemed to ask her to provide lots of things from memory, wasn't eliciting anything spontaneous, but required her to rely upon her rote memory. I thought it was a lot of auditory directions that can be very overpowering to a child with autism and to some adults. I did not feel that what she was able to produce during that time was — that what she actually produced, I think, could have been done in less than two hours of time — that intense time of constantly going over the same things over and over. And I also thought that many times it was really unclear, because it was unclear to me, whether she actually got the answer right or not. It was either "pretty good" or they kept repeating the same question, and she kept answering the same answer. So I think that's confusing. Id., at 185. Ms. McDanel also met with CM's mother after this session in order to obtain additional information for use in preparing an IEP. Id., at 186. She was not told during any of these meetings that *582 there were behavioral problems with CM. Id. Dr. Shea felt that CM's current level of performance was not known and suggested the re-administration of the Brigance test prior to formulating the IEP. Transcript, Vol. IX, at 20-22. The Plaintiffs did not agree to the administration of that test and determined to have private testing done prior to the IEP meeting. Transcript, Vol. V, at 43-45. They chose Dr. Thomas Boyle, a psychologist in New Jersey who in the past had worked with Dr. Lovaas. Id., at 48. Dr. Boyle administered standardized testing but admitted in his report that the standard protocol had to be modified at times in order to allow CM to participate in the task. Respondent's Exhibit 60. Those modifications would have increased her ability to perform well, if they had any impact. Transcript, Vol. XV, at 73. He concluded that if she were placed in a full-day school, she would require 15 to 20 hours per week of one-on-one teaching focusing on her language deficits. Id. Initially, Dr. Boyle included CM's IQ scores in the report; however, her parents asked him to delete them. Transcript, Vol. XV, at 21. When Dr. Boyle prepares an evaluation for a school, it is his normal practice to report the IQ scores. Id., at 95. CM's full scale IQ was 57 which is in the mildly mentally handicapped range. Id., at 94, 113. Her language skills were very poor; and thus, he could not be sure she understood the questions being asked. Id., at 24. He found she was able to respond to some things through rote memory but when a task required understanding the meaning of a sentence, she had difficulty. Id., at 27. Dr. Boyle was contacted again by the Plaintiffs in early 1997. They wanted him to evaluate CM a second time because they felt her true abilities were not shown in the July report and at the time, her medication was being changed. Id., at 57; Respondent's Exhibit 61. CM's mother asked him to use different standardized tests than had been used in the July testing so that no one would think she had been trained on the test. Transcript, Vol. XV, at 57. In Dr. Boyle's opinion, that was an unusual request because "no one has ever said that to me before. No one has ever expressed that someone might do that. But no one has ever requested a reevaluation that quickly either." Id. The Plaintiffs had a particular concern about CM's IQ scores. Id., at 119-20. Dr. Boyle found that CM's IQ scores had increased but she still had significant deficits in expressive and receptive language skills. Id., at 58-59. He did not alter his recommendation. Dr. Boyle was not told of any behavior problems with CM during either evaluation. Id., at 68. The Plaintiffs retained a third person to evaluate CM. Dr. Jan Blacher is an education professor in California who observed both CM and the County's autistic classrooms in August 1996. Dr. Blacher provided written observations to the Plaintiffs concerning the TEACCH classrooms which contained scathing criticisms of the teachers, the aides, and the program in general.[10] Respondent's Exhibit 62. Nonetheless, she testified that CM did not need 40 hours per week of Lovaas therapy and should be in a classroom setting part of the time. Transcript, Vol. VIII, at 13. On August 14, 1996, the parties were finally able to have a meeting concerning CM's IEP for the 1996-97 school year. Respondent's Exhibit 68. The Plaintiffs felt the goals set for CM were very well done. Id. CM's mother expressed her desire that CM be placed in a classroom with "typically developing peers" for half the school day and 20 hours per week of one-on-one instruction. Id. Ms. McDanel stated she was concerned that CM might be unable to adjust and perform in a classroom *583 of 20 children since she had never been with such a large group. Id. At the Plaintiffs' request the meeting was adjourned to a later date when CM's Lovaas consultant would be able to attend. Id. The second meeting occurred on September 13, 1996, and was attended by Michael Guiou, the Lovaas consultant. Respondent's Exhibit 69. Also present was a kindergarten teacher from a regular kindergarten class since there was a possibility CM would be placed there. Id. The Plaintiffs acknowledged that the draft IEP was "a very good IEP" to which they had made minor changes after consulting with Mr. Guiou. Id. Of primary concern was the distinction between individualized instruction versus one-on-one instruction. Id. Ms. Cook explained the two terms could mean the same thing; but, primarily, individualized instruction is instruction designed to meet the unique needs of a child. Id. There would be no guarantee of one-on-one instruction for a certain period of time each week because the teacher is allowed to use the type of instruction necessary to teach the skill involved. Id. Although agreeing that the IEP goals were good, Mr. Guiou felt CM must have one-on-one instruction. Id. Ultimately, Plaintiffs explained that by one-on-one instruction they meant a "shadow," an aide or teacher, should be available throughout each day to assist CM. If she did not understand what the teacher was teaching, the shadow was to step in to assure CM would grasp the task. Id. Plaintiffs agreed that much of the time this person would not be needed; yet, they insisted such a person be available. Id. It was explained that in the County setting such a person was available but not exclusively for CM. Id. Because it was clear an agreement concerning placement could not be reached, the parties went through the IEP goals. Id. When a discussion of individualized versus one-on-one instruction resumed, it was clear that the difference lay in methodology. This meeting lasted for at least half of the day. Transcript, Vol. IX, at 51. During this and the prior meeting there was no mention that CM was experiencing any behavior problems. Id. This was important information because it should have been addressed in the IEP. Id., 52. The next meeting was scheduled for September 23, 1996. At that meeting, Ms. Cook presented significant revisions to the IEP based on the last meeting; and again, the parties reviewed the IEP paragraph by paragraph, page by page. Id., at 54. The parties, and their attorneys, reached an agreement on the goals. Id., at 55. The IEP called for CM to receive a full-day program with half of each day in a regular kindergarten class accompanied at all times by an adult (shadow) to assist as needed, one-on-one instruction from Ms. McDanel, the special education teacher, in reading, math and written language for one and a half hours each day, guided instruction for one hour each day in the autism classroom and three hours of speech therapy each week. Respondent's Exhibit 70. The Plaintiffs responded that they did not want CM in the autistic classroom for any portion of the day because she might learn inappropriate behavior. Id. It was explained that while CM was there the other children in that classroom would either be doing their own "mainstreaming" or independent activities, thus reducing the possibility that CM would see inappropriate behavior and learn to imitate it. Id. The Plaintiffs did not agree and continued to insist on their choice of placement. In addition, they asked that the school system pay for the speech therapist to travel to CM's private school to provide therapy because EM, the mother, did not have the time to take CM to the therapist's private office. Id. It was explained that the school system could not send a therapist into a private school. Id. The IEP drafted for CM for the 1996-97 school year provided for CM to have "one-to-one instruction to learn new academic skills. She needs guided practice with an adult to maintain skills. She needs socialization *584 and communication skills which can best be practiced with typically developing peers. Expanded language goals necessitate additional speech." Respondent's Exhibit 10. As a result, CM was offered a program providing her with five hours per week of guided instruction in the autism classroom, seven and one-half hours of one-on-one instruction, three hours of speech therapy and the remainder of her time in a regular kindergarten classroom accompanied at all times by an adult. Id. The Plaintiffs did not accept the IEP because it did not provide the Lovaas methodology and would have placed CM in the autism classroom for
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56; // convert 12to10 bit (ADC/4) engineConfiguration->injectionMode = IM_BATCH; } /** * MIATA_NA6_MAP */ void setMiataNA6_MAP_Frankenso(DECLARE_CONFIG_PARAMETER_SIGNATURE) { setDefaultFrankensoConfiguration(PASS_CONFIG_PARAMETER_SIGNATURE); setFrankensoConfiguration(PASS_CONFIG_PARAMETER_SIGNATURE); engineConfiguration->isHip9011Enabled = false; CONFIG(isSdCardEnabled) = false; setMiataNA6_settings(PASS_CONFIG_PARAMETER_SIGNATURE); // Frankenso middle plug 2J, W32 top <> W47 bottom "#5 Green" jumper, not OEM engineConfiguration->map.sensor.hwChannel = EFI_ADC_4; engineConfiguration->mafAdcChannel = EFI_ADC_0; // Wide band oxygen (from middle plug) to W52 engineConfiguration->afr.hwChannel = EFI_ADC_13; // PA3 engineConfiguration->vbattDividerCoeff = 9.75;// ((float) (8.2 + 33)) / 8.2 * 2; engineConfiguration->isSdCardEnabled = true; // /** // * oil pressure line // * adc4/pa4/W47 // */ // engineConfiguration->fsioAdc[0] = EFI_ADC_NONE; // warning light /** * to test * set_fsio_setting 1 1800 * set_fsio_setting 2 95 * set_fsio_setting 4 14 * * set_rpn_expression 1 "rpm 0 fsio_setting > coolant 1 fsio_setting > | vbatt 2 fsio_setting < |" * rpn_eval "rpm 1 fsio_setting > coolant 2 fsio_setting > | vbatt 4 fsio_setting < |" */ /* //WARNING: these indeces are off engineConfiguration->fsio_setting[0] = 6400; // RPM threshold engineConfiguration->fsio_setting[1] = 100; // CLT threshold, fsio_setting #2 engineConfiguration->fsio_setting[2] = 13.0; // voltage threshold, fsio_setting #3 // set_fsio_setting 4 3000 engineConfiguration->fsio_setting[3] = 3000; // oil pressure RPM, fsio_setting #4 // set_fsio_setting 5 0.52 engineConfiguration->fsio_setting[4] = 0.52; // oil pressure threshold, fsio_setting #5 */ // * set_rpn_expression 1 "rpm 3 fsio_setting >" // rpn_eval "rpm 1 fsio_setting >" // rpn_eval "fsio_analog_input" // set_fsio_expression 0 "((rpm > fsio_setting(4) & (fsio_analog_input < fsio_setting(5)) | rpm > fsio_setting(1) | (coolant > fsio_setting(2) > | (vbatt < fsio_setting(3)" #if EFI_FSIO // todo: convert setFsio(0, GPIOC_13, COMBINED_WARNING_LIGHT PASS_CONFIG_PARAMETER_SUFFIX); #endif /* EFI_FSIO */ engineConfiguration->injectionPins[0] = GPIOD_3; // #1&3 pin 3U engineConfiguration->injectionPins[1] = GPIOE_2; // #2&4 pin 3V engineConfiguration->injectionPins[2] = GPIO_UNASSIGNED; engineConfiguration->injectionPins[3] = GPIO_UNASSIGNED; // white wire from 1E - TOP of W4 to BOTTOM W62 engineConfiguration->malfunctionIndicatorPin = GPIOD_5; // yellow wire from 1V/W22 to bottom of W48 engineConfiguration->clutchDownPin = GPIOA_3; engineConfiguration->clutchDownPinMode = PI_PULLUP; // 110mm red wire from 1N/W14 to bottom of W45 engineConfiguration->throttlePedalUpPin = GPIOA_7; // green wire from 1Q/W17 to bottom of W46 engineConfiguration->acSwitch = GPIOA_6; #if ! EFI_UNIT_TEST // W57 PE3 A/C compressor relay out engineConfiguration->acRelayPin = GPIOE_3; // W58 PE4 A/C fan relay out #endif /* EFI_UNIT_TEST */ miataNAcommon(PASS_CONFIG_PARAMETER_SIGNATURE); } void setMiataNA6_VAF_Frankenso(DECLARE_CONFIG_PARAMETER_SIGNATURE) { setMiataNA6_MAP_Frankenso(PASS_CONFIG_PARAMETER_SIGNATURE); /** * Stage 0 we only have OEM TPS switch * See throttlePedalUpPin */ engineConfiguration->tps1_1AdcChannel = EFI_ADC_NONE; // todo: MAF-based ignition table? } /** * set engine_type 12 */ void setMiataNA6_VAF_MRE(DECLARE_CONFIG_PARAMETER_SIGNATURE) { setMiataNA6_MAP_MRE(PASS_CONFIG_PARAMETER_SIGNATURE); engineConfiguration->fuelAlgorithm = LM_REAL_MAF; setVafVeTable(PASS_CONFIG_PARAMETER_SIGNATURE); setVafIgnitionTable(PASS_CONFIG_PARAMETER_SIGNATURE); #if (BOARD_TLE8888_COUNT > 0) engineConfiguration->isSdCardEnabled = true; #endif /* BOARD_TLE8888_COUNT */ } void setMiataNA6_MAP_MRE(DECLARE_CONFIG_PARAMETER_SIGNATURE) { setMiataNA6_settings(PASS_CONFIG_PARAMETER_SIGNATURE); miataNAcommonEngineSettings(PASS_CONFIG_PARAMETER_SIGNATURE); engineConfiguration->triggerInputPins[0] = GPIOA_5; engineConfiguration->triggerInputPins[1] = GPIOC_6; engineConfiguration->camInputs[0] = GPIO_UNASSIGNED; engineConfiguration->fuelPumpPin = GPIO_UNASSIGNED; engineConfiguration->twoWireBatchInjection = true; engineConfiguration->useIacTableForCoasting = true; engineConfiguration->idlePidDeactivationTpsThreshold = 90; engineConfiguration->isVerboseIAC = true; engineConfiguration->idleRpmPid.pFactor = 0.01; engineConfiguration->idleRpmPid.iFactor = 0.02; engineConfiguration->idle_antiwindupFreq = 0.1; engineConfiguration->idle_derivativeFilterLoss = 0.1; engineConfiguration->idleRpmPid.dFactor = 0.002; engineConfiguration->idleRpmPid.offset = 37; engineConfiguration->acIdleExtraOffset = 14; engineConfiguration->idleRpmPid.minValue = 30; engineConfiguration->acIdleExtraMin = 14; engineConfiguration->idleRpmPid.maxValue = 70; engineConfiguration->idleRpmPid.periodMs = 40; engineConfiguration->idlerpmpid_iTermMin = -6; engineConfiguration->idlerpmpid_iTermMax = 30; engineConfiguration->pidExtraForLowRpm = 25; engineConfiguration->idlePidRpmDeadZone = 25; engineConfiguration->idlePidRpmUpperLimit = 1000; engineConfiguration->useFSIO12ForIdleOffset = true; setFsioExpression(QUOTE(MAGIC_OFFSET_FOR_IDLE_OFFSET), "ac_on_switch 0 cfg_acIdleExtraOffset if" PASS_CONFIG_PARAMETER_SUFFIX); engineConfiguration->useFSIO13ForIdleMinValue = true; setFsioExpression(QUOTE(MAGIC_OFFSET_FOR_IDLE_MIN_VALUE), "ac_on_switch 0 cfg_acIdleExtraMin if" PASS_CONFIG_PARAMETER_SUFFIX); engineConfiguration->useIdleTimingPid
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" A−T+ cases probably correspond to FTLD (and possibly PART) cases, suggesting that some FTLDs are associated with elevated tau biomarkers. In a broader perspective, "true" A−T+ cases belong to the SNAPs, a concept forged in 2012 to designate A−T+ and/or N+ cases, that is, cases with positive tau biomarkers and/or neurodegeneration markers in neuroimaging (atrophy and/or hypometabolism) [@bib27], [@bib56]. SNAP is not a rare finding in healthy elderly individuals, representing up to 25% of the population, and the relevance of this finding is questionable since SNAP profile does not seem to be associated with cognitive decline [@bib57]. In the population with cognitive decline, the SNAP group is heterogeneous, encompassing cerebrovascular disease, Lewy-body dementia, argyrophilic grain disease, and FTLD or nonspecific hippocampal sclerosis [@bib58]. Within SNAP cases, few studies distinguished A−T+N+ from A+T-N+. A recent survey from a large AD biomarker database showed that 64% of A−N+ cases were T+ [@bib59]. However, this study used high T-tau to define N+, leaving out N+ patients determined by neuroimaging (where atrophy and/or hypometabolism define N+). Furthermore, the Aβ~42/40~ ratio was not used, which overestimates the number of A−T+N+ cases. Altogether, A−T+N+ probably represents a minority of SNAP cases. We show that identification of T+ cases in SNAP is relevant from a clinical point of view because most of them may correspond to FTLD. The two main limitations of the study are the retrospective methodology and the lack of pathological confirmation of the diagnoses. These limitations however do not outweigh the main interest of this multicenteric study, resting in its observational nature. Patients included come from daily care practices, patient groups were established and analyzed in an unbiased way, and the main analysis was based on diagnoses made before the LP. If confirmed by further studies, our results will be easy to generalize to the general population of memory clinic patients. Even if we cannot provide proof that "true" A−T+ cases are underlain by FTLD pathology, patient follow-up (and in a few cases genetics) strengthened or confirmed the diagnosis made before the CSF biomarker results. The third limitation of this study lies in the use of what could appear as arbitrary thresholds to define biomarker positivity, raising the possibility that more stringent thresholds would have yielded very different results. This limitation is shared by all biomarker studies. However, the thresholds we used were defined by multicenter harmonization studies [@bib34], [@bib41]. While we do not deny that some of our cases may correspond to false-positive tau^181P^ results, tau^181P^ was clearly in the pathological range for most patients and associated with elevated T-tau. Furthermore, the rather homogeneous phenotype of "true" A−T+ patients comforts the relevance of our results. Finally, the changes in clinical diagnoses following biomarker analysis should be considered with caution because CSF results may influence clinicians, raising a risk of circular reasoning. This is particularly true in the "false" A−T+ group, where pathological Aβ~42/40~ results may have influenced the clinician toward an AD diagnosis. For this reason, our study primarily focused on diagnoses made before the LP. However, changes in diagnoses following biomarker results in the "true" A−T+ group are of particular interest. First, this situation, deemed uninformative in the 2011 criteria, is equivalent to an absence of biomarkers for most clinicians. Second, although the clinician was possibly influenced toward a non-AD diagnosis, the nature of the diagnosis still holds interest. Overall, our results suggest the Aβ~42/40~ ratio should be systematically calculated in case of discrepancy between normal CSF Aβ~42~ (A−) and high CSF tau^181P^ (T+) because it will reclassify half of cases as A+T+. FTLD is probably the leading cause of A−T+ profiles when defined by the Aβ~42/40~ ratio, and FTLD should be considered in all SNAP cases.Research in Context1.Systematic review: The 2018 National Institute of Aging--Alzheimer\'s Association research framework has validated the Aβ~42/40~ ratio as a surrogate marker of amyloid pathology, which reduces the number of patients with A−T+ profiles. However, the proportion and clinical characterization of T+N+ patients with normal Aβ~42~ in memory clinics remains poorly studied.2.Interpretation: In this retrospective multicenter study, we show that the Aβ~42/40~ ratio halves the number of A−T+ patients. "False" A−T+ patients with normal Aβ~42~ yet abnormal Aβ~42/40~ had higher cerebrospinal fluid tau^181P^ levels and most had a clinical profile congruent with Alzheimer\'s disease. In sharp contrast, frontotemporal lobar degeneration phenotypes are overrepresented in "true" A−T+ patients.3.Future directions: Our study supports the systematic use of the Aβ~42/40~ ratio in T+N+ cases with normal Aβ~42~. Frontotemporal lobar degeneration should be systematically discussed in "true" A−T+ cases. Supplementary data {#appsec1} ================== Supplemental Table 1 This work is the end-of-study dissertation of HPC and TBN for the DIU MA2 course. The DIU MA2 course (Diplôme InterUniversitaire de diagnostic et de prise en charge des Maladies d'Alzheimer et Apparentées) is a National transdisciplinary course on diagnosis and care of Alzheimer\'s disease and related disorders ([www.diu-ma2.fr](http://www.diu-ma2.fr){#intref0010}). The course is supported by the Fondation Alzheimer and the Fondation Vaincre Alzheimer. Supplementary data to this article can be found online at <https://doi.org/10.1016/j.dadm.2019.01.001>. [^1]: Same contribution. [^2]: Abbreviations: AD, Alzheimer\'s disease; bv-FTLD, behavioral variant of frontotemporal dementia; CSF, cerebrospinal fluid; CBS, corticobasal syndrome; SD, standard deviation; FTLD, frontotemporal lobar degeneration; LBD, Lewy body disease; LP, lumbar puncture; MCI, mild cognitive impairment; MMSE, Mini--Mental State Examination; PPA, primary progressive aphasia; PSPS, progressive supranuclear palsy syndrome; VCI, vascular cognitive impairment. If this is your first visit, be sure to check out the FAQ by clicking the link above. You may have to register before you can post: click the register link above to proceed. To start viewing messages, select the forum that you want to visit from the selection below. Ridiculous. Instead of actually changing their business model, they fight tooth and nail to move it backwards. I used to manage a small store. There was a CD player. Occasionally, myself or other employees would bring in CDs to play during the day. You know what it resulted in? People asking what the CDs were, and saying they were going to stop by a record store on the way home and buy them. Instead of looking at it like the free marketing it is, they want to b**** about it being an unlicensed free performance. That may be the dumbest thing I've ever heard. And where do you draw the line? If I get a song from iTunes and download it onto an MP3 player and burn it to CD for my car, they honestly think I stole the song, not once but twice? And if I play my stereo and my wife comes in the room, is that an illegal performance? Another way the music industry doesn't see how they're putting themselves out of business. Corporate stuffed shirts who contribute nothing are now scrambling to salvage their overpriced jobs while they still can before it all comes crashing down. Playing the radio in public is especially ridiculous, what next, suing people for whistling and humming in public? Darth Vader is becoming the Mickey Mouse of Star Wars. "In Brooklyn, a castle, is where dwell I" The use of a lightsaber does not make one a Jedi, it is the ability to not use it. Incidentally, the nonsense in the article Ms. Pariser spews about "stealing" is directly contradicted by the Home Audio Recording Act, so, she can feel free to sue me at any time. the RIAA will lose, and I will win. As far as publicly playing a recording, that is actually illegal, but give the RIAA enough legal rope and they will hang themselves. Really, at the bottom of it, is that record companies are in the business of recording, promoting, distributing, and selling record albums. The real money comes from sales, but the big service they give to artists is in distribution. Once they are no longer needed to distribute albums (as the physical album is being marginalized), bands are going to start wondering why they are continuing to fork over the money. Based on the cavalier attitude the industry has had toward its consumers, I am looking forward to the day the labels die. This feels like a really bad case od Demolition Man pansy assed rules and what not
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Another nAChR partial agonist, lobeline, reported to have smoking cessation activity ([@bib14]; [@bib34]) had effects similar to those of varenicline ([Figure 1A](#fig1){ref-type="fig"}). Chronic exposure to lobeline alone or together with nicotine reduced ^125^I-epibatidine binding levels below that observed for the untreated cells and neurons ('Lob', blue columns in the left, 'live cells' half of the graphs in [Figure 1B,F](#fig1){ref-type="fig"}). The inverted U-shaped concentration-dependence of lobeline effects on upregulation was similar to that of varenicline. ^125^I-epibatidine binding peaked at \~50% of nicotine-induced upregulation, was maximal at 100 nM -- 1 μM, ([Figure 1---figure supplement 1C](#fig1s1){ref-type="fig"}, black circles), and co-incubation with nicotine reduced upregulation exponentially with increasing concentrations of lobeline ([Figure 1---figure supplement 1D](#fig1s1){ref-type="fig"}, black squares). Lobeline therefore has very similar effects as varenicline in preventing nicotine upregulation. Intact HEK cells or neurons were required to observe the block by varenicline and lobeline of nicotine upregulation. If ^125^I-epibatidine binding was performed on membrane fragments instead of intact cells, varenicline upregulated ^125^I-epibatidine binding in α4β2R-expressing HEK cells to the same degree as nicotine and did not reduce nicotine upregulation ([Figure 1B](#fig1){ref-type="fig"}, red columns on right, 'membranes' half of the graph). Lobeline exposure upregulated ^125^I-epibatidine binding to about 50% of that of observed with nicotine treatment and reduced nicotine upregulation by 50% ([Figure 1B](#fig1){ref-type="fig"}, blue columns on right half of the graph). The effects of varenicline and lobeline on nicotine upregulation were therefore distinct in live cells and membrane fragments, which could explain why previous studies found that chronic varenicline exposure upregulated ^3^H-epibatidine binding to brain tissue to the same degree as nicotine and reported no effect of varenicline exposure on nicotine upregulation ([@bib24]; [@bib55]). These experiments were done with membrane preparations, whereas the suppressive activity of varenicline on nicotine upregulation was only observed in intact cells. An intracellular acidic compartment is required for varenicline and lobeline effects on upregulation and ACh-activated currents {#s2-2} ------------------------------------------------------------------------------------------------------------------------------- An attractive hypothesis to explain why intact cells were required for suppression of upregulation is that varenicline and lobeline, as weak bases, are concentrated and trapped in intracellular acidic compartments where they are highly protonated. A schematic of how this might occur is displayed in [Figure 1C](#fig1){ref-type="fig"}. This process was described previously for nicotine in *Xenopus* oocytes expressing α4β2Rs ([@bib25]); furthermore, slow release of nicotine from acidic compartments caused α4β2R desensitization, thereby reducing ACh-induced α4β2R currents. We postulated that similar processes could account for the differential effects of varenicline and lobeline exposure on nicotine-induced upregulation in live cells versus membrane fragments ([Figure 1B](#fig1){ref-type="fig"}). That is, varenicline and lobeline also could be trapped due to protonation, slowly leak out after removal from the extracellular solution, and consequently reduce ^125^I-epibatidine binding and functional upregulation as shown in [Figures 1](#fig1){ref-type="fig"} and [2](#fig2){ref-type="fig"}. To test this hypothesis, we determined if suppression of nicotine upregulation by varenicline and lobeline was relieved by increasing the pH of intracellular compartments, thereby reducing the protonation of the two nAChR ligands. The pH gradient was made more basic using three different strategies. First, live HEK cells were incubated briefly with ammonium chloride (NH~4~Cl; 20 mM) prior to ^125^I-epibatidine binding. We reasoned that this should result in ^125^I-epibatidine binding similar to that observed with the membrane preparation in [Figure 1B](#fig1){ref-type="fig"} (right half) as a result of shifting the equilibrium to uncharged species of the ligands at more basic pHs. NH~4~Cl treatment altered the effects of varenicline and lobeline on ^125^I-epibatidine binding; both ligands produced upregulation of binding ([Figure 1D](#fig1){ref-type="fig"} left half, [Figure 1---figure supplement 1A,C](#fig1s1){ref-type="fig"}), in contrast to their actions at physiological pH ([Figure 1B](#fig1){ref-type="fig"}, leftmost trio of columns). Moreover, NH~4~Cl exposure following co-incubation with nicotine relieved the suppression of upregulation by varenicline and lobeline ([Figure 1D](#fig1){ref-type="fig"}, right trio of columns, [Figure 1](#fig1){ref-type="fig"}-figure supplement B, D), such that ^125^I-epibatidine binding in these conditions were indeed similar to the results using membrane preparations ([Figure 1B](#fig1){ref-type="fig"}, rightmost trio of columns). NH~4~Cl treatment of cultured cortical neurons had similar effects on ^125^I-epibatidine binding after varenicline or lobeline exposures ([Figure 1F](#fig1){ref-type="fig"}, right half of graph). We also obtained similar ^125^I-epibatidine binding results with HEK cells using two other methods to reduce the pH gradient - incubation with the proton pump inhibitor bafilomycin A (Baf, 50 nM; [Figure 1E](#fig1){ref-type="fig"}, [Figure 1---figure supplement 2A](#fig1s2){ref-type="fig"}) or with the weak base chloroquine (Chlor, 150 μM; [Figure 1E](#fig1){ref-type="fig"}, [Figure 1---figure supplement 2B](#fig1s2){ref-type="fig"}). In [Figure 1E](#fig1){ref-type="fig"} is a comparison of how varenicline (Var) or lobeline (Lob) affects ^125^I-epibatidine binding to α4β2R-expressing HEK cells for all of these conditions. When performed on membrane preparations or in conditions that increased the pH of cellular acidic compartments, ^125^I-epibatidine binding was increased consistent with upregulation of α4β2Rs. This upregulation of binding was not observed for intact cells. The second assay we used for α4β2R upregulation was to measure changes in the mean amplitude of ACh-induced currents in the receptor-expressing HEK cells following exposure to nicotine or other agents ([Figure 2](#fig2){ref-type="fig"}). Cells were treated for 17--20 hr as shown; we then carried out whole-cell voltage recordings while rapidly applying ACh (1 mM) for 1 s. Nicotine upregulation of currents from α4β2R-expressing HEK cells was observed as an increase by \~5 fold in mean peak current amplitudes (e.g., [Figure 2A](#fig2){ref-type="fig"}, white vs. black column). Varenicline and lobeline (both at 30 μM) exposure altered the ACh-induced currents in parallel with what we observed in ^125^I-epibatidine binding assays with live cells ([Figure 2A,B](#fig2){ref-type="fig"}). Exposure to varenicline alone did not alter nAChR current amplitudes, whereas lobeline reduced the mean amplitude to below that of control (untreated) receptor currents. When co-incubated with nicotine, both varenicline and lobeline occluded functional upregulation; lobeline treatment again reduced nAChR currents to a mean amplitude below even that of the control group. Neither treatment changed the time course of desensitization of the ACh currents. Thus, varenicline and lobeline prevented nicotine-induced functional upregulation of α4β2R nAChR currents. NH~4~Cl (20 mM) treatment also partly restored nicotine-induced functional upregulation of ACh currents in lobeline and varenicline treated α4β2R-expressing HEK cells ([Figure 2C,D](#fig2){ref-type="fig"}), albeit to a lesser degree than as observed with the binding experiments. We performed additional experiments to test whether varenicline and lobeline are released from intracellular acidic compartments after being trapped in the α4β2R-expressing HEK cells. The protocol is displayed schematically in [Figure 1---figure supplement 3A](#fig1s3){ref-type="fig"}. Briefly, HEK cells chronically treated with varenicline or lobeline for 17 hr were washed to remove free ligands and incubated with NH~4~Cl-containing PBS for 10 min, which we predicted would cause varenicline or lobeline to be rapidly released from intracellular acidic compartments. The supernatant from the treated cells was then added to a different set of receptor-expressing HEK cells that had not been exposed to varenicline or lobeline. ^125^I-epibatidine binding was performed on the second set of cells to test whether each supernatant contained competitive ligands that reduced binding (indicative of the
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a military exercise, the entire area has been sealed off." "It appears the virus was stolen from the Athena lab yesterday at 5 PM." "But the report came in this morning, correct?" "While they decided what to do, the report may have been delayed." "Our vaccine stockpile is close to zero." "The vaccine is enroute from the U.S. but it won't reach us in time." "If we attempt to seize the airship the deal is off and the bomb will be detonated according to the terrorists." "Based on their MO, we view the crime as the doing of M-108 rogues." "The police can't be mobilized." "The government will balk at terrorism and accept their demands." "Even if they give in I don't foresee the bomb threat being fended off." "I agree." "The remote-control has a 5km range." "The transmission source has to be mobile." "Find a suspicious vehicle in the area." "The perps are M-108 rogues." "What if the airship gets blown up?" "The deadly virus on board was developed by the U.S. military in secret with our government." "It's a level 4 virus." "It has a 90% infection and death rate." "What's that?" "Mommy." "What is it?" "An air balloon." "Wow." "Amazing." "Suspicious vehicle at Central Station!" "Stolen vehicle." "Get to Central Station!" "Hebopie, left flank!" "They used the vaccine." "They're gonna release the virus." "They dumped their van!" "Like a needle in a haystack." "The boss is a real slave driver." "In a crisis situation, I alone have clearance to use this specialized system." "All monitoring cameras across the nation can be controlled from here." "I have the authority to access all personal info." "We're cross-checking the data of everyone at the station." "The public is not aware of this." "They must never know that we have classified secrets like this." "With this system, PSU monitors and spies on all citizens." "What are you investigating?" "I can't confirm the claim of the Self-Defense Forces training in the peninsula." "So?" "The missing cargo vessel was last seen near the Manazuru peninsula." "Something's about to go down." "This is a no smoking zone." "Your phone." "It's the news desk." "Just hang up on them!" "Hello..." "No, he's not with me right now." "Get out of Tokyo." "Huh?" "Get her out of town." "Huh?" "What... who are you?" "Listen up." "Do it now." "One more thing..." "Yes?" "Carry your own ash tray from now on." "Toudou?" "Where did you go?" "What are you doing?" "The database found a match." "Michael Shibata from M-108." "Current location, the airport train concourse." "The airport train concourse." "Hebopie." "Down, down!" "Incoming call from the Attorney General!" "Kiryu here." "The government approved their demands." "The money's been wired." "Transfer confirmed." "Deactivate the bomb?" "No need." "Let hell break loose." "The timer hasn't been deactivated!" "Are they gonna escape?" "Apprehend them." "Force them to deactivate the bomb." "Take them alive." "Force them to deactivate the bomb." "Cease fire!" "Don't kill them!" "Don't shoot!" "Don't shoot." "Nobody fire." "Move!" "The only one who can disarm the bomb is me." "What's with the chick?" "Three minutes left!" "You're all gonna die." "So are you man." "Who the fuck is this chick!" "?" "We won't die." "We used the vaccine." "We'll take you with us." "Say Hiba..." "Who are you pointing your gun at?" "Disarm the bomb!" "Move." "Hold your fire!" "If you don't, millions will die!" "I don't give a damn!" "Disarm the bomb!" "I'll kill you too!" "What's going on?" "Who do I shoot?" "Hiba!" "Shoot Hiba?" "I'll kill all of you!" "Shut the hell up!" "He killed my family." "He stole my life." "I'll kill anyone who stands in my way!" "One minute left." "What's this chick done?" "Let's all die together." "He's alive!" "Now that's being prepared." "The code now!" "That vest won't save you now." "Start recovering the virus and bomb." "Ten years ago, at the Universal Square Bombing they robbed me of everything." "It was like a scene from hell." "I was the sole survivor." "To find the men responsible for the explosion and kill them myself." "I've lived to honor that pledge." "Then six months ago I found one of them." "From his cell phone I was able to identify four of the seven men and killed them." "I knew who you were..." "So..." "I got close to you." "That night..." "While you were asleep, I rigged a tracking device to your cell." "I figured that following you would lead me to the remaining targets." "And I found the fifth man as planned." "But I couldn't do it myself." "Two targets remain." "My revenge has not yet been fulfilled." "Let... ..it go." "If you want to stop me..." "You'll have to kill me." "If you want to shoot, go right ahead." "A fighting fish much like me, can only live in solitude." "And chances are she's not "living" either." "The bomb and virus have been recovered." "Fighting poison with poison." "Thanks to your Wild 7, any serious harm was prevented." "Yesterday, if the theft had been reported when it happened wouldn't the men on that ship have been saved?" "I couldn't say." "What I do know is that an evil capable of snuffing out 15 lives with ease is part of the world we live in." "SYNDICATE MEMBERS DIE IN SHOOT-OUT" "It's just like you said something serious did happen!" "Toudou?" "You think the Wild 7 were behind this?" "Give it a rest already!" "What's wrong?" "Is your father..." "I don't have a father." "Don't remember one anyway." "Oh, that's right." "My bad." "That came out of nowhere." "These are the stock trends of the U.S. drug company that created the vaccine." "As the crisis situation went public their stock went through the roof." "So what?" "After the virus was stolen and the NY stock exchange opened someone purchased massive shares in their stock." "Once the stock sky-rocketed, he sold and made 2 billion yen." "What's that mean?" "Beats me." "So somebody made a killing on the stock market, eh?" "So they blackmailed the nation and made money on the market?" "But, how do dead people sell their stock?" "They don't." "It was someone with first-hand knowledge of the virus being stolen." "Kiryu from PSU knew." "Kiryu has made billions by using PSU intel on the market." "And this wasn't the first time neither." "There's been a time lag between the PSU reports and the moment the police is informed." "Huge stock deals took place in these cases as well." "Making big money by delaying PSU reports?" "I envy the guy." "Tragedy might've been prevented." "A lot of people died 'cause of him!" "What do you want us to do?" "UNIVERSAL SQUARE BOMBING" "UNIVERSAL SQUARE BOMBING Fire him already!" "Fire him already!" "Use your head and figure something out your damn self." "It's not our job." "He's just like the others." "Just another roach that needs to be exterminated." "So..." "You're here too, eh?" "I know what you've discovered and why you're here." "While you were day trading how much blood washed off on your hands?" "I saved a 10,000 times more lives." "And merely claimed a suitable fee for all my work." "You truly believe that?" "Protest all you want." "Neither the nation nor the media would listen to you." "Even playing them this conversation would be a waste of time." "I hold all the trump cards." "As you know, I control a secret weapon, the public can never know about." "But that's not all." "I control our nation's darkest secrets." "Political scandals, corporate leaks, trade secrets, intel on the underworld." "Secrets that would change the world, if ever they became public." "With this power who would dare touch me?" "I don't live in fear." "I'm shielded by both the government and the crime organizations." "You still wish to defy me?" "Is there any point to your work?" "The Wild 7 are meaningless." "Evil never dies." "You can't kill it." "History has proven that much." "Therefor..." "You must coexist with evil." "Like I do." "It's your call, Kusanami." "Let him walk." "Let him
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of the now, “No Chill” and “U Mad.” Kanye was not on hand to assist Vic. Sadly. Check out the footage courtesy of Pitchfork, after the jump. After the overwhelming success of A3C Volume 4, the A3C Hip-Hop Festival has renewed its partnership with iHipHop Distribution to bring a diverse array of new hip-hop to fans across the globe with A3C Volume 5. Drake is back with his barrel still aimed at Meek Mill. This time he’s using “Back to Back” to go directly at Meek — slandering the rapper’s name and proving that Drizzy is the best in the game. In case “Charged Up,” the previous diss track was a little too soft for you then Drake’s got some serious ammunition in his cannon for “Back to Back.” Basically: Don’t fuck with Drake. Let’s see if we can get a Meek Mill response. Check out “Back to Back” after the jump. Joell Ortiz comes through with a fire verse on Canadian artist Jerzee’s new track “Houses in NY,” which is a the perfectly titled track for a New York rapper like Ortiz. Don’t get me wrong, this is a fine track but it’s all about Ortiz here. Check out “Houses in NY” after the jump. Verbal Kent links up with Freddie Gibbs on “Suitcase Switch,” a track that is also produced by Apollo Brown. The two Midwestern rappers exchange a bevy of spitfire verses that’ll leave you wanting more. In addition, Apollo’s soulful production along with those knocking drums will be the perfect backdrop to your hot summer day. Check out “Suitcase Switch” by Verbal Kent after the jump. There’s still so much good music coming out of Chicago that it bums me out to think sites no long feel the need to pay attention.. But there are still solid rappers like Lil Herb who are attempting to bridge the gap between the oft-misunderstood drill sound and the mainstream. Kanye merely coopted the movement — Lil Herb is out here leading it. With “NnoOne or Nothing” Herb links up with a Chi-Town rap collective known as Goodbye Tomorrow. Peep it, maybe you’ll dig it. After the jump… Juicy J, hot off of releasing his Blue Dream & Lean 2 mixtape, is dropping the visuals for “Whole Thang,” which is on the aforementioned mixtape. It also features Wiz Khalifa, who has been having himself a low key great year. Check out “Whole Thang” after the jump. El-P, who is busy with many endeavors, including his Run the Jewels project with Killer Mike, has recently told reporters that he would be contributing some new music for the upcoming Fantastic Four film. The full track has now arrived via Rolling Stone. Check out the new exclusive El-P track for Fantastic Four via Rolling Stone after the jump! Sign up for mobile SMS alerts (e.g. 2223334444 no dots) Msg&data rates may apply. To unsubscribe, text STOP to 313131 (393939 in Canada). For help text HELP anytime. Available in USA & Canada. Up to 5 msg/mo. Your privacy is always protected and your information will not be shared.The BW2 Doubles Tourney Signups After a successful doubles tourney for Black and White and the advent of the Smogon Doubles metagame, this tournament aims to explore double battles in the B&W2 metagame outside of VGC rules. This tournament will follow the rules of Standard Doubles as seen here: http://www.smogon.com/forums/showthread.php?t=3476469 RULES: Single elimination format Battles are to be played on Pokemon Showdown. Battles may be played on Pokemon Online if both parties agree beforehand. • There will be 32, 64, or 128 participants depending on the number of signups. EDIT: 48 because math • First come first serve for the first 62.5% players with the remaining players randomized. • I will pick subs. • Signups will be open for 48 hours.Many soil-derived particles dominated by insoluble material, including Saharan dusts, are known to act as ice nuclei. If, however, dust particles can compete with other atmospheric particle types to form liquid cloud droplets, they have a greater potential to change climate through indirect effects on cloud radiative properties and to affect the hydrological cycle through precipitation changes. By directly collecting and analyzing the residual nuclei of small cloud droplets, we demonstrate that Saharan dust particles do commonly act as cloud condensation nuclei (CCN) in the eastern North Atlantic. Droplet activation calculations support the measurements by showing that due to its slightly hygroscopic nature, even submicron dust can be important as CCN. Given the dual nature of Saharan dust particles as CCN and ice nuclei, this infusion of dust is expected to impact not only droplet size and albedo in small clouds, but ice formation in deep convective clouds.------------------------------------------------------------------------ -- The Agda standard library -- -- Implications of nullary relations ------------------------------------------------------------------------ {-# OPTIONS --without-K --safe #-} module Relation.Nullary.Implication where open import Data.Bool.Base open import Data.Empty open import Function.Base open import Relation.Nullary open import Level private variable p q : Level P : Set p Q : Set q ------------------------------------------------------------------------ -- Some properties which are preserved by _→_. infixr 2 _→-reflects_ _→-dec_ _→-reflects_ : ∀ {bp bq} → Reflects P bp → Reflects Q bq → Reflects (P → Q) (not bp ∨ bq) ofʸ p →-reflects ofʸ q = ofʸ (const q) ofʸ p →-reflects ofⁿ ¬q = ofⁿ (¬q ∘ (_$ p)) ofⁿ ¬p →-reflects _ = ofʸ (⊥-elim ∘ ¬p) _→-dec_ : Dec P → Dec Q → Dec (P → Q) does (p? →-dec q?) = not (does p?) ∨ does q? proof (p? →-dec q?) = proof p? →-reflects proof q? Q: AutoLayout won't content fit UITableView cells I attempted to follow what I've read here on how to content-fit UITableView cells. However, the cells are still clipping content. See below: The cell: (Connected to my custom cell class) The constraints: (All constraints set to the ContentView) The custom cell class: import UIKit class S360SSessionTableCell: UITableViewCell { @IBOutlet var iconImg:UIImageView! @IBOutlet var locationLbl:UILabel! @IBOutlet var dateLbl:UILabel! @IBOutlet var startTimeLbl:UILabel! @IBOutlet var endTimeLbl:UILabel! override func awakeFromNib() { super.awakeFromNib() } override func setSelected(selected: Bool, animated: Bool) { super.setSelected(selected, animated: animated) } } The implementation: These are the only table related methods. In addition, I have this in viewDidLoad: myTableView.estimatedRowHeight = 100.0 //Table Datasource func tableView(tableView: UITableView, cellForRowAtIndexPath indexPath: NSIndexPath) -> UITableViewCell { var cell:S360SSessionTableCell? = tableView.dequeueReusableCellWithIdentifier("S360SSessionTableCell") as? S360SSessionTableCell if ((cell == nil)){ tableView.registerNib(UINib(nibName: XIBFiles.SESSIONTABLECELL, bundle: nil), forCellReuseIdentifier: "S360SSessionTableCell") cell = tableView.dequeueReusableCellWithIdentifier("S360SSessionTableCell") as? S360SSessionTableCell } var session = sessions[indexPath.row] cell!.locationLbl.text = (session["location"] as! String) + " - " + "Court " + (String(session["subname"])) dateFormatter.dateFormat = "MMM. dd, yyyy" cell!.dateLbl.text = dateFormatter.stringFromDate(session["startDate"] as! NSDate) dateFormatter.dateFormat = "hh:mm a" cell!.startTimeLbl.text = dateFormatter.stringFromDate(session["startDate"] as! NSDate) cell!.endTimeLbl.text = dateFormatter.stringFromDate(session["endDate"] as! NSDate) return cell! }
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cinema institute asked to rent the Nunez family apartment as the setting for the movie. The institute didn’t offer much - 40 pesos a day, or about $4 at the time. But the deal came with free breakfast, lunch and dinner daily during a time of severe shortages. After the film was released, foreigners occasionally found their way to the Nunez apartment and asked to look inside. Some suggested he open a private restaurant there under a new government initiative to create new kinds of income during financial hardship. Nunez got a license and opened the restaurant in 1996. But popularity came slowly. “We spent afternoons playing dominoes on the balcony for months, waiting for people to come,” Nunez recalled. But when he hosted an exhibit by Cuban photographer Korda, famed for taking an iconic image of revolutionary Ernesto “Che” Guevara, La Guardia suddenly became a sensation. Since then, Queen Sofia of Spain and American actor Jack Nicholson have dined there. It now even has its own Web page. Traveling here twice with food photographer Martin Jacobs, Cox visited La Guarida and numerous other paladars for her cookbook, which includes 120 recipes from kitchens around Havana. They also visited state-run restaurants and private homes, sampling dishes, collecting recipes, talking with cooks. Because the decades-old embargo and travel restrictions bar most Americans from traveling here, they came with a U.S. license as consultants for an American food company. “We just immersed ourselves in the food,” she said. Cox said she was impressed by Cuban chefs’ resourcefulness in a country plagued by frequent shortages, making “the best of what they have, using pure, clean flavors and practicing simplicity in number of ingredients.” Most paladars have menus far less sophisticated than La Guarida’s - with the most common dishes being basic chicken, pork or fish dishes. But all have an overabundance of ambiance. “The paladars are magical places, stylish and eclectic,” Cox said. At La Esperanza paladar in Havana’s leafy Miramar neighborhood, guests sip minty mojito cocktails waiting for their table in overstuffed sofa and chairs in the living of the restaurant owner’s family home, decorated with weathered statues of popular Catholic saints, old white-and-black family photographs, and other eclectic bric-a-brac. La Esperanza’s tables are set with mismatched porcelain china and silverware. The house specialty is a 1950s-era dish of tender pork stewed in a popular malt soft drink. Also on the menu is a spicy Thai-style chicken dish, and a simple grilled fish filet. Visitors to the Cocina de Liliam paladar, where former U.S. President Jimmy Carter ate during his May 2002 Cuba trip, sit on a patio surrounded by lush ferns and a trio of burbling fountains as they munch crunchy fritters of a root vegetable called malanga. And at Cactus de 33, Fernando Barral, retired psychologist and former comrade of “Che” Guevara, displays Cold War-era mementos including a Communist Party newspaper clipping of him interviewing U.S. POW John McCain, now the presumptive Republican U.S. presidential candidate, during a 1970 trip to Vietnam for research on the North Vietnamese. At Cactus de 33, guests dine on juicy grilled chicken breasts accompanied by white rice and black beans as they sit on the front porch of the huge white mansion, surrounded by towering cactus plants. “There is a lot of creativity,” Cox said. “I don’t think it is a mistake that a place that has created such great artists and dancers and musicians has also created such great cooks.”# Project-wide Gradle settings. # IDE (e.g. Android Studio) users: # Gradle settings configured through the IDE *will override* # any settings specified in this file. # For more details on how to configure your build environment visit # http://www.gradle.org/docs/current/userguide/build_environment.html # Specifies the JVM arguments used for the daemon process. # The setting is particularly useful for tweaking memory settings. #org.gradle.jvmargs=-Xmx1536m # When configured, Gradle will run in incubating parallel mode. # This option should only be used with decoupled projects. More details, visit # http://www.gradle.org/docs/current/userguide/multi_project_builds.html#sec:decoupled_projects #org.gradle.parallel=true # These are set by “Migrate to AndroidX” refactor # When set to true, the Android plugin uses the appropriate AndroidX library instead of a Support # Library. The flag is false by default if it is not specified. android.enableJetifier=true # When set to true, the Android plugin automatically migrates existing third-party libraries to use # AndroidX by rewriting their binaries. The flag is false by default if it is not specified. android.useAndroidX=true # Add the following to ~/.gradle/gradle.properties to build devrelease/release # Key info for creating the development release in the android market #devStorefile=/path/to/keystore #devStorePassword=keystorepassword #devKeyAlias=devkeyalias #devKeyPassword=devkeypassword # Key info for creating real releases #releaseStorefile=/path/to/keystore #releaseStorePassword=keystorepassword #releaseKeyAlias=releasekeyalias #releaseKeyPassword=releasekeypassword Florida State cornerback Jalen Ramsey. Credit: Getty Images By of the Green Bay – Just because quarterbacks Jared Goff and Carson Wentz are expected to go 1-2 in the draft Thursday night doesn't mean they're the two best players. Cornerback Jalen Ramsey is the best player in the draft, and it isn't even close. In a Journal Sentinel poll this month of 19 national-oriented personnel men, Ramsey dominated as the best player in the draft regardless of position. Here were the vote totals: Jalen Ramsey, CB, Florida State (7). Laremy Tunsil, T, Mississippi (3 ½). Myles Jack, LB, UCLA (2 ½). Joey Bosa, DE, Ohio State (2). Jaylon Smith, LB, Notre Dame (2). Carson Wentz, QB, North Dakota State (2).Joss was amazing. He spoke of all of his writing coming from a "dark place," the feeling of being helpless, and devising characters to rescue him...and he said that, ultimately, the opposite of helplessness for him is respect. He also said that the cancellation of Firefly taught him the true meaning of grief...that episodes and stories that are fully fledged in his head will never be lived by those characters. He was absolutely gracious at the after party...allowing fans, who at the prospect of his leaving, finally overcame their awe and reticence, to overwhelm him with last minute photo and autograph requests. One great moment was when Joss was asked if he would like to apologise for the current vampire trend.. Twilight etc.., he said that it was all Anne Rice's fault, he just read "Interview with a vampire" and to top it off the next questioner got up and said Hi Joss My Name is Bella. As expected, but nevertheless more than I anticipated, the evening was hilarious, insightful and just plain fun. Oh, and that Joss kid? An added bonus. Okay, so right down to the nitty-gritty details. Joss' entrance was every kind of awesome: Wil Anderson - who was genuinely funny, engaging and looked extremely at ease next to Joss - introduced the purple man, who emerged from behind the curtains to the Buffy theme, smoke, multi-coloured lights and huge applause and cheers from the audience. The format differed somewhat from the Melbourne Writers Festival going by reports yesterday. Joss spoke about how these interviews/Q&A sessions often followed a linear pattern and that they'd broached many of the same topics time and time again, so he would try to deviate from the trends. Having said that, he then went on to take the stage by himself for while, discussing the reasons why he writes, referring to the "dark place" of "need and pain" that will always characterise and inform his work. He also said that he will always write about helplessness, given that the past few days have allowed him to really reflect on why he writes. His talk centred on his life - how he'd never really had a male role model and was "scared" and "alone" as a youth - mutually exclusive as they were. The relationships that stood out for him were those with his mother and stepsister, both of them females. He talked about his avatars as outlets and spoke particularly about Buffy as, in essence, himself - something he hadn't realised throughout the series' run and until quite recently (in the past few days) - emphasising that he wrote her to "save" himself. He has enormous respect for his characters and despite
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slipped out of maiden shame and said: 'Attack Nevil for his political heresies and his wrath with the Press for not printing him. The rest concerns his honour, where he is quite safe, and all are who trust him.' 'If you find out you're wrong?' She shook her head. 'But if you find out you're wrong about him,' her father reiterated piteously, 'you won't tear me to strips to have him in spite of it?' 'No, papa, not I. I will not.' 'Well, that's something for me to hold fast to,' said Colonel Halkett, sighing. CHAPTER XXXVIII. LORD AVONLEY Mr. Everard Romfrey was now, by consent, Lord Avonley, mounted on his direct heirship and riding hard at the earldom. His elevation occurred at a period of life that would have been a season of decay with most men; but the prolonged and lusty Autumn of the veteran took new fires from a tangible object to live for. His brother Craven's death had slightly stupefied, and it had grieved him: it seemed to him peculiarly pathetic; for as he never calculated on the happening of mortal accidents to men of sound constitution, the circumstance imparted a curious shake to his own solidity. It was like the quaking of earth, which tries the balance of the strongest. If he had not been raised to so splendid a survey of the actual world, he might have been led to think of the imaginary, where perchance a man may meet his old dogs and a few other favourites, in a dim perpetual twilight. Thither at all events Craven had gone, and goodnight to him! The earl was a rapidly lapsing invalid. There could be no doubt that Everard was to be the head of his House. Outwardly he was the same tolerant gentleman who put aside the poor fools of the world to walk undisturbed by them in the paths he had chosen: in this aspect he knew himself: nor was the change so great within him as to make him cognizant of a change. It was only a secret turn in the bent of the mind, imperceptible as the touch of the cunning artist's brush on a finished portrait, which will alter the expression without discomposing a feature, so that you cannot say it is another face, yet it is not the former one. His habits were invariable, as were his meditations. He thought less of Romfrey Castle than of his dogs and his devices for trapping vermin; his interest in birds and beasts and herbs, 'what ninnies call Nature in books,' to quote him, was undiminished; imagination he had none to clap wings to his head and be off with it. He betrayed as little as he felt that the coming Earl of Romfrey was different from the cadet of the family. A novel sharpness in the 'Stop that,' with which he crushed Beauchamp's affectedly gentle and unusually roundabout opening of the vexed Shrapnel question, rang like a shot in the room at Steynham, and breathed a different spirit from his customary easy pugnacity that welcomed and lured on an adversary to wild outhitting. Some sorrowful preoccupation is, however, to be expected in the man who has lost a brother, and some degree of irritability at the intrusion of past disputes. He chose to repeat a similar brief forbidding of the subject before they started together for the scene of the accident and Romfrey Castle. No notice was taken of Beauchamp's remark, that he consented to go though his duty lay elsewhere. Beauchamp had not the faculty of reading inside men, or he would have apprehended that his uncle was engaged in silently heaping aggravations to shoot forth one fine day a thundering and astonishing counterstroke. He should have known his uncle Everard better. In this respect he seemed to have no memory. But who has much that has given up his brains for a lodging to a single idea? It is at once a devouring dragon, and an intractable steamforce; it is a tyrant that has eaten up a senate, and a prophet with a message. Inspired of solitariness and gigantic size, it claims divine origin. The world can have no peace for it. Cecilia had not pleased him; none had. He did not bear in mind that the sight of Dr. Shrapnel sick and weak, which constantly reanimated his feelings of pity and of wrath, was not given to the others of whom he demanded a corresponding energy of just indignation and sympathy. The sense that he was left unaided to the task of bending his tough uncle, combined with his appreciation of the righteousness of the task to embitter him and set him on a pedestal, from which he descended at every sign of an opportunity for striking, and to which he retired continually baffled and wrathful, in isolation. Then ensued the dreadful division in his conception of his powers: for he who alone saw the just and right thing to do, was incapable of compelling it to be done. Lay on to his uncle as he would, that wrestler shook him off. And here was one man whom he could not move! How move a nation? There came on him a thirst for the haranguing of crowds. They agree with you or they disagree; exciting you to activity in either case. They do not interpose cold Tory exclusiveness and inaccessibility. You have them in the rough; you have nature in them, and all that is hopeful in nature. You drive at, over, and through them, for their good; you plough them. You sow them too. Some of them perceive that it is for their good, and what if they be a minority? Ghastly as a minority is in an Election, in a lifelong struggle it is refreshing and encouraging. The young world and its triumph is with the minority. Oh to be speaking! Condemned to silence beside his uncle, Beauchamp chafed for a loosed tongue and an audience tossing like the well-whipped ocean, or open as the smooth sea-surface to the marks of the breeze. Let them be hostile or amicable, he wanted an audience as hotly as the humped Richard a horse. At Romfrey Castle he fell upon an audience that became transformed into a swarm of chatterers, advisers, and reprovers the instant his lips were parted. The ladies of the family declared his pursuit of the Apology to be worse and vainer than his politics. The gentlemen said the same, but they were not so outspoken to him personally, and indulged in asides, with quotations of some of his uncle Everard's recent observations concerning him: as for example, 'Politically he's a mad harlequin jumping his tights and spangles when nobody asks him to jump; and in private life he's a mad dentist poking his tongs at my sound tooth:' a highly ludicrous image of the persistent fellow, and a reminder of situations in Moliere, as it was acted by Cecil Baskelett and Lord Welshpool. Beauchamp had to a certain extent restored himself to favour with his uncle Everard by offering a fair suggestion on the fatal field to account for the accident, after the latter had taken measurements and examined the place in perplexity. His elucidation of the puzzle was referred to by Lord Avonley at Romfrey, and finally accepted as possible and this from a wiseacre who went quacking about the county, expecting to upset the order of things in England! Such a mixing of sense and nonsense in a fellow's noddle was never before met with, Lord Avonley said. Cecil took the hint. He had been unworried by Beauchamp: Dr. Shrapnel had not been mentioned: and it delighted Cecil to let it be known that he thought old Nevil had some good notions, particularly as to the duties of the aristocracy--that first war-cry of his when a midshipman. News of another fatal accident in the hunting-field confirmed Cecil's higher opinion of his cousin. On the day of Craven's funeral they heard at Romfrey that Mr. Wardour-Devereux had been killed by a fall from his horse. Two English gentlemen despatched by the same agency within a fortnight! 'He smoked,' Lord Avonley said of the second departure, to allay some perturbation in the bosoms of the ladies who had ceased to ride, by accounting for this particular mishap in the most reassuring fashion. Cecil's immediate reflection was that the unfortunate smoker had left a rich widow. Far behind in the race for Miss Halkett, and uncertain of a settled advantage in his other rivalry with Beauchamp, he fixed his mind on the widow, and as Beauchamp did not stand in his way, but on the contrary might help him--for she, like the generality of women, admired Nevil Beauchamp in spite of her
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of Sheffield degree, fake The University of Sheffield diploma, buy fake The University of Sheffield degree, fake The University of Sheffield transcript, buy degrees, how to buy fake The University of Sheffield diploma,how to buy fake The University of Sheffield degree, how to buy The University of Sheffield transcript, there are more than 25000 students from 128 countries of the world. As one of Britain's most famous "red brick university", The university of Sheffield is many famous university established in one hundred in Britain is one of The most internationally prestigious world-class university, The university for The country's top universities alliance Russell Group (The Russell Group), The European university association (EUA), The world university union (WUN), white roses university union members. 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In the most authoritative QS world university rankings, 2013-2014 at the university of Sheffield ranked 71th.Leave a Comment Screw diamonds, the dildo hoverboard is a girl’s best friend Don’t you just hate it when you need to give the ol’ honey pot a little self-loving but you’ve got an early morning meeting at work that you’re already late for? Me too. That’s why I’m totally psyched for the creator of the Dildo Drone, Michael Krivicka, and his newest invention: the Dildo Hoverboard. Okay, so maybe it’s a faux invention, but think of the possibilities if it were real. The faux-prototype Dildo Hoverboard presents a speedy way to get to work, perfect for the busy millennial, while also giving its rider the option to multitask with a little, you know, somethin’-somethin’. forces a taboo act into the public sphere for all to see The device is, the product’s YouTube advertisement claims, “fully adjustable” with an “easy to use control panel” where you can pick your personal favorite thrusting speed and rhythmic vibration. Not stated in the ad is the potential for a pretty awesome ab workout. I mean, imagine the balance required to maintain the straight posture while also hitting all the right places. But perhaps the best part of the Dildo Hoverboard is how it forces a taboo, secretive act into the public sphere for all to see and revel in. It could inspire a whole new era of openness and sex-positivity! And what better timing, for May was National Masturbation Month. What’s it hurt to extend it for one extra day? I’ll bring the maypoles. But wait, you may say, this is actually really creepy and I don’t think I’d feel comfortable standing next to someone in line at the Starbucks enjoying their new Dildo Hoverboard. To that I say, is it really as creepy as the very not-faux lap pillow, though? Hold on, you may say again, isn’t public masturbation illegal in most states? And to that I say, no comment. Check out the Dildo Hoverboard and Krivicka’s other faux inventions here.Grace makes early goal stand up against HU soccermen Sunday, September 23, 2012 12:24 PM Host Grace made a goal in the opening minutes last the entire game and hung a 1-0 loss on the Huntington University men's soccer team on Saturday, Sept. 22. Grace's Austin Altimus slipped one behind Forester goalie Drew Mattingly just 5:02 into the contest, and the hosts made it stand up as Huntington dropped to 5-3-2 on the season and 0-1 in the Crossroads League. Mattingly had three saves on the afternoon, but was outdone by Grace goalie Collin Cone, who stopped all six shots Huntington fired at him./***************************************************************************** * RasterPropMonitor * ================= * Plugin for Kerbal Space Program * * by Mihara (Eugene Medvedev), MOARdV, and other contributors * * RasterPropMonitor is free software: you can redistribute it and/or modify * it under the terms of the GNU General Public License as published by * the Free Software Foundation, either version 3 of the License, revision * date 29 June 2007, or (at your option) any later version. * * RasterPropMonitor is distributed in the hope that it will be useful, but * WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY * or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License * for more details. * * You should have received a copy of the GNU General Public License * along with RasterPropMonitor. If not, see <http://www.gnu.org/licenses/>. ****************************************************************************/ using System; using UnityEngine; // FIXME: This module turned into total spaghetti by now and needs some serious rethinking. namespace JSI { public class FlyingCamera { private readonly Vessel ourVessel; private readonly Part ourPart; private GameObject cameraTransform; private Part cameraPart; private readonly int fxCameraIndex = 6; private readonly string[] knownCameraNames = { "GalaxyCamera", "Camera ScaledSpace", "Camera VE Underlay", // Environmental Visual Enhancements plugin camera "Camera VE Overlay", // Environmental Visual Enhancements plugin camera "Camera 01", "Camera 00", "FXCamera" }; private readonly Camera[] cameraObject = { null, null, null, null, null, null, null }; private readonly float cameraAspect; private bool enabled; private bool isReferenceCamera, isReferenceClawCamera, isReferenceTransformCamera; private ModuleGrappleNode clawModule; private Part referencePart; private const string referenceCamera = "CurrentReferenceDockingPortCamera"; private readonly Quaternion referencePointRotation = Quaternion.Euler(-90, 0, 0); private float flickerChance; private int flickerMaxTime; private int flickerCounter; public float FOV { get; set; } public FlyingCamera(Part thatPart, float aspect) { ourVessel = thatPart.vessel; ourPart = thatPart; cameraAspect = aspect; } public void SetFlicker(float flicker, int flickerTime) { flickerChance = flicker; flickerMaxTime = flickerTime; flickerCounter = 0; } public bool PointCamera(string newCameraName, float initialFOV) { CleanupCameraObjects(); if (!string.IsNullOrEmpty(newCameraName)) { FOV = initialFOV; if (newCameraName == referenceCamera) { JUtil.LogMessage(this, "Tracking reference point docking port camera."); return PointToReferenceCamera(); } else { isReferenceClawCamera = false; return CreateCameraObjects(newCameraName); } } else { return false; } } private bool PointToReferenceCamera() { isReferenceCamera = true; referencePart = ourVessel.GetReferenceTransformPart(); ModuleDockingNode thatPort = null; ModuleGrappleNode thatClaw = null; if (referencePart != null) { foreach (PartModule thatModule in referencePart.Modules) { thatPort = thatModule as ModuleDockingNode; thatClaw = thatModule as ModuleGrappleNode; if (thatPort != null || thatClaw != null) { break; } } } if (thatPort != null) { if (!LocateCamera(referencePart, "dockingNode")) { cameraPart = thatPort.part; cameraTransform = ourVessel.ReferenceTransform.gameObject; isReferenceTransformCamera = true; } isReferenceClawCamera = false; return CreateCameraObjects(); } else if (thatClaw != null) { // Mihara: D
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, suggesting that race-related amygdala activity may result from cultural learning rather than from the novelty of other races. Additionally, verbal encoding of African-American targets produced significantly less amygdala activity than perceptual encoding of African-American targets.Jewel scarab The Ruteline genus Chrysina, or jewel scarabs (not to be confused with jewel beetles which are a different family), is a large genus of brightly colored, often metallic iridescent species, ranging from the southwestern edge of the United States as far south as Ecuador. The genus includes all the species formerly known as Plusiotis. They are typically between in length, and are nocturnal in habits, coming readily to lights. The larvae live in rotting logs, while the adults commonly feed on foliage; they tend to be found in pine, juniper, or pine-oak forests, most commonly between elevation. They are most diverse in countries such as Honduras, where as many as 15 species can be found in a single location. There are only 4 species which occur in the United States (see taxobox). These beetles are very popular among collectors; many species are polymorphic, with rare color variants that can command high prices. One such specimen was featured on the cover of National Geographic Magazine. The majority of species are bright green, but metallic silver and gold are also common colors, and may be combined with green as in the common Chrysina gloriosa from the Madrean sky islands region. Particularly attractive specimens were reported to sell for as much as $500 in 2007. References External links Generic Guide to New World Scarab Beetles Category:RutelinaePosted! Join the Conversation Comments Welcome to our new and improved comments, which are for subscribers only. This is a test to see whether we can improve the experience for you. You do not need a Facebook profile to participate. You will need to register before adding a comment. Typed comments will be lost if you are not logged in. Please be polite. It's OK to disagree with someone's ideas, but personal attacks, insults, threats, hate speech, advocating violence and other violations can result in a ban. If you see comments in violation of our community guidelines, please report them. MADISON, Wis. — The Michigan football team said all week that it wanted to make a statement against Wisconsin. It did so — but not in the manner it was hoping for. The Wolverines were embarrassed in a 35-14 blowout at Camp Randall Stadium on Saturday. U-M was undisciplined, unprepared — and just plain bad. The performance was a stunning indictment of the players and coaching staff, who had two weeks to prepare for the Badgers. It was an ominous sign for a program that was expected to contend for a Big Ten championship this season. Wisconsin Badgers running back Jonathan Taylor leaps for a first down during the first quarter against the Michigan Wolverines at Camp Randall Stadium, Sept. 21, 2019.(Photo: Jeff Hanisch, USA TODAY Sports) The nightmare began almost immediately, when Wisconsin marched down the field with ease on its opening drive and took a 7-0 lead. Wisconsin coach Paul Chryst went for it on fourth-and-inches in his own territory, trusting that his offense could gain 1 yard. It did, and the Badgers eventually scored a touchdown — the first of three crucial fourth-down conversions. Chryst's decision, along with his team's execution, set the tone for the rest of the game. Michigan’s offense looked poised to respond on the ensuing drive after a 68-yard pass from Shea Patterson to Ronnie Bell — but two plays later, defensive tackle Ben Mason fumbled the ball away. It was all downhill from there. Wisconsin scored 28 consecutive points, throttling Michigan's run defense to the tune of 357 rushing yards. The Wolverines were outschemed and outplayed, giving up two touchdowns even after Jonathan Taylor — who had 12 carries for 143 yards and two touchdowns in the first half — exited with cramps. It was not much better on offense. Patterson faded quickly after the big play to Bell, finishing 6-for-17 for 96 yards and one interception in the first half. He was benched for backup Dylan McCaffrey on Michigan’s final possession before the half, only re-entering when McCaffrey left due to injury. Michigan struggled to make anything work. The offensive line gave up pressure, the run game was non-existent and the pass game was out of sync. The big question coming into the season was whether the Wolverines’ new offense would be more reliable and able to keep up with high-scoring opponents. So far, through the first three weeks of the season, the answer is a resounding no. Michigan’s offense has looked worse with each passing week. The Wolverines' first-half performance was their worst under Jim Harbaugh. Compounding matters, Michigan came out nearly as flat after halftime. Which leads to an even more pressing discussion of the program's trajectory. Michigan looked like a rebuilding team on Saturday — not a team that was supposed to contend for a Big Ten title and the College Football Playoff.Quantitative autoradiographic localization of [125I]alpha-bungarotoxin binding sites in the honeybee brain. Binding sites for the nicotinic acetylcholine receptor antagonist, [125I]alpha-bungarotoxin, were localized in the honeybee brain by in vitro autoradiography. Highest binding site densities were localized in the suboesophageal ganglion, the optic tubercles, optic lobes medulla and lobula, antennal lobes, dorsal lobes and the alpha-lobes of the mushroom bodies. The distribution pattern of these putative nicotinic acetylcholine receptors suggests that acetylcholine is involved in several sensory pathways and in central information processing in the honeybee brain.The GBI released the footage from three deputy body cameras to Channel 2 Action News amid an investigation into the incident. The incident started at the Newnan Crossing Shopping Center near Bullsboro Drive about 2:30 a.m. A deputy, who was on patrol at the shopping center, noticed a car parked in the lot behind the T-Mobile cellphone store, GBI spokeswoman Nelly Miles previously said. The deputy notified dispatch and got out of his patrol car to investigate. RELATED: Coweta County deputy shoots man after chase and crash, GBI says In the video, a deputy finds Bolton asleep in the back seat of a white SUV. Bolton appears to stir when the deputy shines his flashlight through the window. He appears to be lying on piles of his belongings. The video shows Bolton climb into the front seat. At that point, the deputies begin speaking with him through the window of the SUV. “Let me explain something to you real quick,” a deputy says. “We don’t know you. We’re investigating why you’re here.” “For what?” Bolton asks in reply. “For loitering,” the deputy says. “You’re loitering. And now that you’re not stepping out of the car, you’re obstructing an investigation. So you can either get out and talk to us, or we can take you out and go to jail.” The video shows the deputy once again giving Bolton the options of getting out or going to jail. He then appears to put the car in drive and begins pulling out of the parking spot. Deputy John Collins Credit: Coweta County Sheriff's Office Credit: Coweta County Sheriff's Office The video shows a deputy pointing a gun at Bolton’s vehicle as he pulls off. The deputy commands Bolton to turn the car off as he continues driving away. The deputies climb back into their patrol cars and a chase ensues. According to the video, the chase lasts less than a full minute before Collins uses a PIT maneuver to stop Bolton’s SUV. Deputies previously said Bolton’s car was still running, wheels spinning, following the crash. The GBI’s statement said deputies tried to box in Bolton’s car with a patrol car, then walked over to him. The GBI said Collins fired “after he saw what he believed to be Bolton actively trying to drive his vehicle in the direction of the (second) deputy.” In the video, Bolton’s vehicle spins and appears to come to a stop facing Collins’ patrol car. The deputy’s car appears to roll forward a little more and come to rest against Bolton’s SUV. The second deputy pulls to the left side of Bolton’s vehicle, blocking it in. That deputy then steps out and gives Bolton a verbal command to get out of the car. Collins then appears to fire through the man’s windshield. The time between the second deputy stepping out of his car and Collins firing his gun appears to be less than three seconds, according to the video. RELATED: Dashcam video shows tense moments before fatal shooting Four deputies then surround Bolton’s car with guns drawn, the video shows. One breaks the window of the locked SUV in order to open Bolton’s door. A deputy alerts dispatch that Bolton has a gunshot wound to the head, but is breathing. A voice is heard saying; “Was there a weapon?” “No,” a deputy says. Bolton was taken to Atlanta Medical Center. No officers were injured in the shooting, the GBI previously said. Collins, who has been
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these changes, she is just starting a bit earlier. “We strongly advocate starting puberty education in school in the fall semester of fourth grade whether or not the majority of the class is going through it,” says Deardorff. “Just to normalize it.” When you talk to her about her body, remember that she isn’t experiencing the sexual maturation that comes later in puberty. The hormonal mood swings and sexual feelings associated with puberty won’t start until closer to the time of her first period, which will likely happen closer to the time the rest of her peers get theirs. So when you explain what is happening to her, use language that is appropriate for her age and don’t sexualize the changes her body is going through. Buy her bras that look like tank tops or clothes she would wear. “Do lots of normalizing,” says Deardorff. “And deal with body shaming issues, bra snapping and such, as they come up with the school. Don’t be afraid to go talk to the teacher. But keep it all positive. Remind her that bodies come in all shapes and sizes. She should be proud of hers and take good care of it.”Walt Whitman said "Do I contradict myself? Very well then I contradict myself, I am large, I contain multitudes." Among my multitudes are Buddhism, pacifism, polyamory, self-examination, libraries, and science. Perhaps my various adventures will be interesting to others. Sunday, September 28, 2008 Well he wouldn't have, would he, if he wasn't egged on by Athena?And she, well, she eggs on Ares too. "Ares, Ares,destroyer of men, reeking blood, stormer of ramparts,why not let these mortals fight it out for themselves? (36) Yeah Athena, why dontcha? Athena has done as Zeus ordered...got the Trojan Pandarus to send the first arrow. He strikes Diomedes, but the goddess-fueled warrior treats it as but a scratch. Athena's not fighting fair, does this for Diomedes: Look, I've lifted the mist from off your yesthat's blurred them up to now--so you can tell a god from man on sight. ...if Aphrodite daughter of Zeus slips into battle,she's the one to stab with your sharp bronze spear! (147) Before Diomedes wades back into battle, he instructs young Sthenelus to get Aeneas' horses. The horses man! They are the very strain farseeing Zeus gave Tros (293) Diomedes strikes a crippling blow with rock, but Aeneus is saved by....anybody? anybody?Aphrodite! And once upon a time all these relations would have been entirely transparent to the audience...like Homer, Bart, and Lisa are to me. So Diomedes wounds Aphrodite...after all, Athena gave him the green light. But Apollo's got her back. A piercing shriek--she reeled and dropped her son,But Phoebus Apollo plucked him up in his handsand swathed him round in a swirling dark mist...But Diomedes shouted after her, shattering war cries:"Daughter of Zeus, give up the war, your lust for carnage!So, it's not enough that you lure defenseless womento their ruin? (393) (While her wrist is wounded, Aphrodite's heart writhes in pain.)Dione the light and loveliest of immortals (431) reminds Aphrodite "the man who fights the gods does not live long." (466) Athena taunts her in front of Father Zeus, who says, I paraphrase, "There there sweetie pie, keep the home fires burning and let Athena and Ares do the dirty work of war."(is this a war between the Trojans and the Argives, or between Apollo and Athena?) ...Phoebus Apollo, lord of the golden sword,who ordered Ares to whip the Trojans' war lustonce he spotted Athena veering off the lines,great Palla who'd rushed to back the Argives. (590) All those video game sheroes, they must be based on Athena: Then Athena, child of Zeus whose shield is thunder,letting fall her supple robe at the Father's threshold--rich brocade, stitched with her own hands' labor--donned the battle-shirt of the lord of lightning,buckled her breastplate geared for wrenching warand over her shoulders slung her shield, all tasselsflaring terror-- (846) Athena goads Diomedes for his waning fight. He blames her...she's said he couldn't fight the immortals but the one, yet clearly Ares was involved. So she says, Go for it! So even Ares is wounded and goes to complain to the Great Father. My, is Athena untouchable? Zeus scolds Ares, "No more, you lying, two-faced...no more sidling up to me, whining here before me.You--I hate you most of all the Olympian gods.Always dear to your heart,strife, yes, and battles, the bloody grind of war.You have your mother's uncontrollable rage--incorrigible,that Hera--say what I will, I can hardly keep her down.Hera's urgings, I trust, have made you suffer this. (1035) Book 6: Hector Returns to TroyMenelaus (Helen's cuckolded husband) captures a man alive whose "horses snared themselves in tamarisk branches." (47) (I had to look that up. Photo by flickr user RobW) The man begs for his life, but the ever noble Agamemnon sneers at Menelaus for showing any concern for an enemy. Diomedes gets snitty when Glaucus starts fighting in his territory. Glaucus, son of Hippolochus has the requisite blue blood though, so they become best buddies. Diomedes says, "...The men must know our claim:we are sworn friends from our fathers' days till now!"Both agreed. Both fighters sprang from their chariots, clasped each other's hands and traded pacts of friendship.But the son of Cronus, Zeus, stole Glaucus' wits away.He traded his gold armor for bronze with Diomedes,the worth of a hundred oxen just for nine. (282) And the Trojan women? All they get to do is pray. Which they do, to "Queen Athena--shield of our city--glory of goddesses! Now shatter the spear of Diomedes." (361) Heh. Good luck with that. Hasn't changed has it? Both sides praying to the same god? And each side thinks god likes them better? I want to know more about Helen. She's bitter about Paris. She calls herself a whore, a bitch, vicious, scheming. (408) Did she willingly run away with Paris (albeit under the spells of Aphrodite) or did he steal her away against? Did the men of the time see no difference? Hector's wife Andromache seems to have a good mind for strategy. ...Take your stand on the rampart here,before you orphan your son and make your wife a widow.Draw your armies up where the wild fig tree stands,there, where the city lies most open to assault,the walls lower, easily overrun. Three timesthey have tried that point, hoping to storm Troy... (516) But Hector doesn't want to look cowardly. Even worse, he doesn't want to lose and have Andromache be enslaved. Andromache is sure he's made the wrong decision. Hector leaves again for battle. And his loving wife went home, turning, glancingback again and again and weeping live warm tears.She quickly reached the sturdy house of Hector,man-killing Hector,and found her women gathered there insideand stirred them all to a high pitch of mourning.So in his house they raised the dirges for the dead,for Hector still alive, his people were so convincedthat never again would he come home from battle,never escape the Argives' rage and bloody hands. (600) That can't be good. I bet the Fates are just giggling maniacally.Book 7: Ajax Duels with Hector Paris suits up, keeps pace with Hector. Who knew? OK, first they arranged the Paris vs Menelaus duel...that didn't work. Now Apollo and Athena arrange another duel, Hector vs whomever. Isn't that doomed to failure too? Are they just trying to make the game interesting? So Hector obliges, issues the challenge. You could hear the crickets chirp..."a hushed silence went through the Achaean ranks, ashamed to refuse, afraid to take his challenge...." (107) They do the Ancient Greek equivalent of drawing straws. Internal monologues whisper, let it be Ajax let it be Ajax. And it's Ajax! Who acts like that's what he wanted. So why didn't he just step forward
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to her artistic precocity and her supportive parents, Jones attended Boston's High School of Practical Arts. An outstanding student, she formed a close, lasting bond with guidance counselor Laura F. Wentworth, who followed her career closely, always worrying that Jones would imperil her health by working too hard. In the meantime, Jones won a scholarship to attend vocational drawing classes at the Museum of Fine Arts. After her regular school day ended at two o'clock, she would "take the long walk" to the museum and draw until four thirty, maintaining this demanding schedule for four years. At the same time, she managed to become an apprentice to Grace Ripley, a costume and stage designer and professor at the Rhode Island School of Design. In her Boston studio, Ripley was busy creating costumes for the Ted Shawn School of Dance. Shawn was a trailblazer, elevating American modern dance to the status of a true art form by celebrating dance as a universal and sacred art form and drawing on diverse cultures in his revolutionary choreography. Jones worked at Ripley's studio on Saturdays and in the evenings. The designer would hand her a quick sketch to work from, and Jones would complete the design and make the costumes, including those involving batik and tie-dyeing. Jones also made papier-mâché masks based on African art. African masks would become enormously significant to her mature work and worldview. What did Jones do when she wasn't in art class, the studio, or the museum? She attended Sunday school and church, and volunteered for community activities, thus setting the course for her life as a humanitarian as well as an artist. In an interview with Kathleen Ayers of the United States Information Service (USIS) in 1955, Jones explains that her mother and teachers emphasized and encouraged her "artistic bent" when she was a child, "but for some time I thought I wanted to be a social worker so I could do something for people. When I was 12 I used to visit a Boston community center to tell stories to the younger children." While in college, drawing on her burgeoning love for dance and drama, Jones founded the Pierrette Club for Girls under the auspices of the League of Women for Community Service in Boston. "Pierrette" is the female version of Pierrot, the central character in commedia dell'arte, and Jones's large (thirty members) and ambitious theater club met weekly and produced plays. She was president and her mother was club mother, in addition to being "her most intimate and steadfast personal supporter," offering "constant affirmation and praise." She ran the club for ten years, and said that she loved "working with those girls." This impulse to help others also kept Jones teaching for forty-seven years, and motivated her remarkable outreach work as an art ambassador, especially in Africa, as well as her work organizing and overseeing student trips abroad. Her interest in others and her compassion infused her paintings. Ayers notes that Jones's paintings were tagged as "happy art"; "For joie de vivre, a warm friendliness and instinctive belief in the goodness of people and the world are salient characteristics of this talented Negro artist." In spite of this now jarring racial designation in a piece written a decade before the civil rights movement, Ayers's is a respectful and laudatory article, one that Jones carefully saved. In 1968 she told _Ebony_ magazine that she was still comfortable with the "happy art" description. "Even though I sometimes portray scenes of poor and struggling people," she says, "it is a great joy to paint." Irrepressible and energetic Jones loved to swim and play tennis, even participating in tournaments, in addition to playing basketball and serving as team captain. As she observed, "All of these activities made my life so full and helped me to be a very healthy person." These extracurricular activities also helped Jones win a coveted scholarship to attend the School of the Museum of Fine Arts, Boston, as one of only two African American students. Practicality ruled when she decided to major in design, and she graduated in 1927 with honors. In addition to her coursework, Jones spent long hours in the museum, where she particularly loved studying the textile and ceramic collections. She also simultaneously attended evening classes at the Boston Normal Art School (now the Massachusetts College of Art), where she earned a teaching certificate. Yet another scholarship enabled her to attend graduate school at the Design Art School of Boston, from which she received a diploma in 1928. Fully certified, Jones began working as a freelance textile designer for the F. A. Foster Company in Boston and New York's Schumacher Company, creating fresh and intricate patterns for cretonne, a strong cotton or linen cloth with a dull finish that is used in curtains and upholstery. _Loïs Mailou Jones._ Design for Cretonne #13 _. ca. 1932. Tempera on paper. 27 x 21 inches._ Jones's lushly patterned textile designs from the late 1920s and early 1930s, rendered in watercolor and tempera with pizzazz, are ravishing. The details are entrancing and exuberantly inventive in their intricate forms, fresh themes, and skilled color dynamics. Some designs are botanical (palm trees, birds of paradise, leaves), some jazzily abstract. She achieves a Navajo look and Caribbean and African auras. In analyzing Jones's textile creations, curator Lowery Stokes Sims writes, "references to a multiplicity of cultural and media phenomena seemed to flow effortlessly and copiously from the well of Jones's creative impulses." Jones's superb design sense is detectable in all her paintings, no matter their subject or style. But as gorgeous as her textile designs were, and as successful as this young designer became, there were serious drawbacks to this endeavor, beginning with racial prejudice. Cautious about revealing herself to white art directors, Jones had a white friend take her designs along as part of her portfolio. Jones's work sold, while her friend's did not. Once her designs were in production, Jones decided to visit one of her best customers in New York and introduce herself. When she arrived, she saw that one of her motifs, titled _Ganges_ , had been used to upholster an entire set of showroom furniture. Jones, a master at understatement, was in for another jolt on a trip to Martha's Vineyard: "During the drive to the island, I saw my designs draped in the show windows of interior decorator shops. What a good feeling it was to know that I had designed them! But only the name of the design, printed on the borders of the fabric, was known, never the name of the artist who created it. That bothered me because I was doing all this work but not getting any recognition. And I realized I would have to think seriously about changing my profession if I were to be known by name." Jones was quite clear about this. She later reiterated, "As I wanted my name to go down in history, I realized that I would have to be a painter. And so it was that I turned immediately to painting." The frustrations continued. Seeking employment in keeping with her decision to change her focus from applied to fine art, Jones went to see the director of the Boston Museum School, where she had excelled, hoping for a position there, as had been offered to other outstanding students. But instead of a job offer, she received this bit of barbed advice: "He very kindly looked at me and said, 'Loïs, we don't have any opportunities here, but have you ever thought about going South to help your people?' That was a shock to me, because here I was a young Boston lady exposed to Radcliffe and Simmons and Harvard and Tufts and all of the big schools... to be told to go South was something I really didn't anticipate." Again, her scorching, matter-of-fact irony. But Jones was a quick study and a resolute individual with a gift for turning adversity into opportunity. Soon after this appalling exchange, she went to a party at a friend's place and met a professor from Howard University, the preeminent, historically African American institution founded in Washington, D.C., shortly after the Civil War. Bostonian Jones knew little if anything about Howard, but the professor impressed her, and with his encouragement, she decided to apply for a teaching position there. She was told that she would be considered, but they hired one of their own, the newly graduated James A. Porter, who went on to have a distinguished and influential career there. Jones would have to wait. But she never stayed still. As part of her pursuit of continual education, she attended Sunday lectures by black scholars at a Boston community center. One week, she listened closely when educator Catherine Hawkins Brown, then director of the Palmer Memorial Institute, a black elite prep school and junior college in Sedalia, North Carolina, told the audience, "We _need_ you young people in the South." Jones marched up to Brown and asked if the school had an art department. It did not. Jones told Brown that she would like to come down and build one. "She thought I was too young and would not be able to do it." Jones prevailed. People would be wise not to underestimate this pretty, sweet-voiced, petite yet mighty woman. In Brown, however, she had a formidable opponent. Brown wrote to Jones on July 23, 1928, "You understand that you will have to do pioneer work here. We have nothing but a blank room, but will fix it up on your suggestion." Brown made many demands, beginning with her reaction to the "snappy little sports-car" Jones bought herself for the solo journey from Boston to Sedalia. "She
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were identified and validated using a five-phase process. The profile was inspired by CanMEDS framework developed for medicine but adapted for the occupational therapy profession \[[@CR6], [@CR7]\]. The central role in occupational therapy is the expert in enabling occupation and is surrounded by six transversal roles: communicator (e.g. engaging in effective dialogue and written documentation) collaborator (e.g. working in teams and managing conflict), practice manager (e.g. prioritizing duties and supervision of trainees), change agent (e.g. advocating for occupation), scholarly practitioner (e.g. using of evidence-based practice and reflexive practice) and professional (e.g. committed to ethical practice and high personal standards of behaviour) \[[@CR4]\]. Although Lal, Klein & Brown \[[@CR3]\] reinforced the importance of studying the competence level of occupational therapists with master's entry-to-practice educational preparation, only a few articles on the topic exist. Two studies compared the perceived competence level of occupational therapists holding a baccalaureate versus a master's. One study dating back to over 30 years, found that those with a master's degree reported greater confidence in their competence as compared to those with a baccalaureate \[[@CR8]\]. In another study, while both groups searched for information for similar reasons, those holding a master's frequently used scientific databases to search information, whereas those with a baccalaureate often consulted colleagues for similar information \[[@CR9]\]. Another thirteen articles, one being more than 30 years old, focused primarily on one of the seven roles with the scholar role being the most studied (8/13 articles) \[[@CR9]--[@CR16]\], followed by the role of expert in enabling occupation \[[@CR17], [@CR18]\], collaborator \[[@CR19], [@CR20]\] and only one focusing on the professional role \[[@CR21]\]. Enactment of these competencies does not solely rely on occupational therapists' initial training and understanding of personal and contextual factors that facilitate or hinder their use, maintenance and development in authentic practice settings is urgently needed. Objective {#Sec2} ========= The overarching aim of this study was to describe the ways in which occupational therapists (OTs) with an entry-to-practice master's degree perceived their enactment of the seven roles \[[@CR4]\] in actual practice. More precisely, we aimed to describe: clinicians' perceived competency level for the seven roles of the Profile \[[@CR4]\];the individual and organizational factors (facilitators and barriers) perceived as impacting clinicians' ability to enact key competencies relating to the seven roles in their daily practice and;the strategies used by OT clinicians with an entry-to-practice master's degree to maintain and further develop their competency level for the seven roles. This study endorses the definition of competence at an individual level as the effective combination and mobilization of internal (i.e. skills, attitudes, knowledge) and external resources (e.g. working environment, roles and responsibilities, physical and organizational demands) in a set of situations and contexts \[[@CR22]\]. Methods {#Sec3} ======= We used a two-phase mixed methods sequential design \[[@CR23], [@CR24]\]. Phase 1 consisted of an online survey (objective 1) and phase 2 involved qualitative focus group discussions (objectives 2 and 3) with the aim to deepen our understanding of phase 1 results. Ethics approval was obtained from the Health Research Ethics Board of the University of the first author. Participants provided written consent to participate to phase 1 and further verbal consent to participate to phase 2 as focus groups were held online. Participants {#Sec4} ------------ The study was conducted in Quebec, Canada. All occupational therapists holding an entry-to-practice master's degree, who are members of the *Ordre des ergothérapeutes du Québec*, the Provincial regulatory organization, and who consented to be contacted for research purposes when submitting their annual registration renewal, were eligible to participate in this study (*n* = 1196) and were therefore contacted through e-mail. There were no exclusion criteria. Data collection for phase 1 {#Sec5} --------------------------- The online survey was developed simultaneously in French and English (given the bilingual demographic of this large Canadian province) using a four-step process adapted from Devellis' 8-step process of scale development \[[@CR25]\]: 1) a list of indicators for each of the seven roles of the Profile \[[@CR4]\] was developed based on literature; 2) indicators were added to this list to ensure all seven roles were covered; these were framed as questions by the research team using a constant iterative process moving between the literature and the research team discussions until consensus was reached; 3) this beta version of the survey was improved for its content using focus group discussion \[[@CR26]\] with academic experts (n = two groups of 4--5 individuals) as well as individual interviews (*n* = 3) with managers; 4) this first version was then pre-tested online (*n* = 60). This process resulted in a reduction in the number of questions (72 questions initially reduced to 40 questions) to ensure it could be completed in less than 10 min. The final survey was composed of 46 questions including sociodemographic characteristics. Data collection for phase 2 {#Sec6} --------------------------- This second phase targeted objectives 2 and 3 of the study. Participants from phase 1 (online survey) were invited to provide their contact information if they agreed to be contacted (*n* = 103/317; 32.5%) for phase 2 (focus group discussion). For this second phase, purposeful sampling was used to include, occupational therapists working with a variety of clientele of all ages including physical and mental health as well as public and private practice settings. The focus group protocol included open-ended questions targeting three main areas: 1) overall perceived competency level (i.e. which role was perceived as highest versus lowest competency level); 2) individual and organizational factors \[[@CR27]\] perceived as impacting one's ability to enact key competencies in practice; and 3) strategies used in practice to maintain and further develop competency level. A list of probes (e.g. Which (roles) do you consider better or worse for you or your colleagues and can you give a concrete example? What about 'expert in enabling occupation'? In other words, we asked them to provide examples of situations in which the different roles were perceived as being enacted and to further comment on how these were either easy or challenging) for each of these three areas was used as needed to foster discussion. We used a semi-inductive approach as the probes used to collect information about individual and organizational factors were anchored in the Theoretical Domains Framework \[[@CR27]\]. All focus groups were conducted in French (no first English-language speakers volunteered for phase 2), recorded and transcribed verbatim. The quotes used in the manuscript were translated using [www.deepl.com](http://www.deepl.com) and further checked for accuracy by bilingual team members. Data analysis {#Sec7} ------------- We used descriptive statistics (mostly frequency and percentage) to analyze the survey data and Pearson Chi square statistics or exact Fisher's test (two-sided test) to explore associations between perceived competence level on the seven roles and specific variables (e.g. time since graduation, taking on a preceptor role, working in private/public setting and clientele being physical/mental health). Analysis was done using IBM SPSS statistics Version 25. Focus group data (transcribed verbatim) were analyzed using the Framework approach \[[@CR28]\]. This thematic approach allows for making explicit links within the different steps of the analysis; an iterative process is used to move between raw data, codes and emerging themes. We used the seven roles of the Profile \[[@CR4]\] and the components of the Theoretical Domains Framework \[[@CR27]\] as an initial coding grid to which open coding was added. The Theoretical Domains Framework was developed to investigate factors potentially influencing specific behaviours change in practice and its refined version contains 14 domains (e.g. knowledge, beliefs about capabilities or social influences) \[[@CR27]\]. Coding and results were discussed in a team meeting until consensus was reached. Trustworthiness \[[@CR29]\] was established through the following processes: Authenticity was addressed by using probes during focus groups and inviting participants to provide concrete examples corresponding to their specific contexts. Confirmability was achieved by having a different co-facilitator from the research team and an observer taking notes in a log book. This was further promoted in data analysis by using theories (Profile and Theoretical Domains Framework) as a preliminary coding grid. The log also ensured dependability, that is, stability of results in similar conditions, by noting any changes made in the research process. Finally, to ensure credibility, available data from all six focus groups were included into the data analysis and all participants were invited to freely express their views using the 'turn and talk' procedure. We also used an iterative process where emerging themes from one focus group was further explored with subsequent ones (e.g. *Previous participants told us x, what do you think, is it the same for you?*) Credibility was also achieved using triangulation, that is, different sources of information such as the survey (phase 1), log and post focus groups synthesis were used throughout the analytical process. Results {#Sec8} ======= Sample characteristics {#Sec9} ---------------------- Characteristics of online survey respondents (Phase 1) are presented in Table [1](#Tab1){ref-type="table"}. The response rate was 26.5% (*n* = 317/1196). Most respondents held a clinician role (*n* = 308/317; 97.2%) whereas 17% (54/317) held multiple roles. Three
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Merial; 2 ml; 50 µg/ml; IM) and fitted with a progesterone-releasing intravaginal device (Eazi-Breed CIDR, Zoetis; 1.38 g progesterone) that was left in place for 7 days. On day 7, the intravaginal device was removed and bovine were given synthetic prostaglandin cloprostenol (Estrumate, Merck Animal Health; 2 ml; 250 µg/ml; IM) to induce luteolysis. Three days after the first dose of cloprostenol, all bovine were given a second dose of GnRH (Cystorelin; 2 ml; 50 µg/ml; IM). Six days after the second dose of GnRH, uteri and ovaries were examined by transrectal palpation and ultrasonography (MyLab Five VET, Esaote; 5 mHz linear rectal probe) to confirm the presence of a corpus luteum and an antral follicle. All six animals were randomly assigned to one of two groups: a diestrus group (DE, *n* = 3) and a periestrus group (PE, *n* = 3). Twenty four hours after transrectal ultrasound examination, those selected as part of the PE group were given a second dose of cloprostenol (Estrumate; 2 ml; 250 µg/ml; IM) to elicit luteolysis ([@ref-17]). In the bovine, periestrus is a period of the estrus cycle encompassing −3 days to +4 days from estrus ([@ref-17]). Estrus behavior and LH hormone levels were not determined; therefore, this period was defined as a non-progesterone dominated phase of the bovine estrous cycle. Euthanasia and sample collection were carried out 24 h after transrectal examination for animals in the DE group and 24 h after the second dose of cloprostenol for animals in the PE group. Before termination, blood samples were taken by jugular venipuncture, and harvested plasma was stored at −20 °C until assayed using the estradiol (ImmunChem Double antibody, MP Biomedicals) and progesterone Coat-A-Count Kit (Siemens Medical Solutions Diagnostics). Both assays have been previously validated in the bovine ([@ref-40]; [@ref-90]). Bovine were euthanized and hypothalami collected and fixed as previously described ([@ref-51]). Briefly, animals were given 50,000 IU heparin (Sigma) i.v. and euthanized with an i.v. dose of sodium pentobarbital (20 mg/kg) 15 min later. After decapitation, the carotid arteries were catheterized, basilar arteries clamped off, and heads perfused with 6 liters of 4% paraformaldehyde in 0.1 M phosphate-buffered saline, with 0.1% sodium nitrite, pH 7.4. Hypothalamic blocks were dissected with the following margins: rostrally--rostral border of the optic chiasm; caudally--rostral to the mammillary bodies; laterally---1 cm off midline, lateral to the optic chiasm; and dorsally---0.5 cm above the third ventricle. Tissue was stored in 4% paraformaldehyde at 4 °C overnight and then placed in 30% sucrose at 4 °C until infiltration was complete. Thick (50 µm) frozen coronal sections were cut in series of six and stored at −20 °C in a cryopreservative solution until being processed immunohistochemically. Immunohistochemistry -------------------- Neuropeptides were detected using a modified avidin-biotin-immunoperoxidase protocol with 3,3′-diaminobenzidine as chromogen (brown reaction product). The immunohistochemistry procedure was carried out on free-floating sections at room temperature, except for incubation with primary antibodies, which were performed at 4 °C, as previously described ([@ref-20]). Briefly, sections were repeatedly washed in 0.1 M phosphate buffer with 0.9% saline (PBS) to remove cryoprotectant. Sections used for the detection of kisspeptin were subjected to high-temperature antigen retrieval as previously described ([@ref-77]). After washing, the sections were placed in a 1% hydrogen peroxide (Sigma) solution for 10 min to remove endogenous peroxidase activity for chromogen detection. The sections were then washed and incubated for 1 h in PBS containing 4% normal donkey serum (Jackson Laboratories) and 0.4% Triton X-100 (Sigma; PBSTX). Alternate sections were then incubated with polyclonal antibodies against GnRH (rabbit host; 1:10,000; PA1-121; ThermoFisher Scientific), kisspeptin (rabbit host; 1:30,000; generously provided by Alain Caraty, Institut National de la Recherche Agronomique), RFRP-1/3 (rabbit host; clone GA197; 1:30,000; generously provided by Greg Anderson, University of Otago School of Medical Sciences), or DYN A 1--17 (rabbit host; 1:20,000; IHC 8730; Peninsula Laboratories) for 48 h in PBTX. Following incubation, chromogen sections were washed and then placed in a solution of PBSTX with biotinylated donkey anti-rabbit IgG (1:1,000; Jackson Laboratories) for 1 h. The sections were washed and incubated for 1 h in avidin-biotin-HRP complex (1:1,000; Vector Laboratories). Neuropeptides were visualized using 3,3′-diaminobenzidine and 0.003% hydrogen peroxide as substrate. Control sections for the immunohistochemistry procedure included omission of each of the primary antibodies from the immunostaining protocol, which resulted in a complete absence of staining for the corresponding antigen. In addition, pre-absorption controls were performed for each of the antibodies. In each case, pre-incubation of the diluted antiserum with nanomolar concentrations of purified antigen (Phoenix Pharmaceuticals) was shown to be sufficient to eliminate all specific staining in bovine hypothalamic sections. It should be noted that the rabbit anti-RFRP1/3 clone was generated from the precursor peptide, which produces both RFRP-1 and RFRP-3 ([@ref-101]); therefore, labeling the precursor effectively defines RFRP-1/RFRP-3-expressing neurons ([@ref-70]). The dynorphin A 1--17 antibody shows cross-reactivity with dynorphin A 1--13 and none with other prodynorphin derivatives such as dynorphin A 1--8, *α*-neo-endorphin, leu-enkephalin, and dynorphin B ([@ref-21]). The kisspeptin antibody was made from the peptide YNWNSFGLRY-NH2 (kp10), corresponding to amino acid residues 43--52 of mouse metastin. This sequence has high homology to the predicted bovine protein (GenBank accession number [AB466319.1](AB466319.1)). RFRP precursor peptide antiserum was generated to amino acids 119-132 of the rat RFRP precursor peptide sequence (PSLPQRFGRTTARR), which matches that of the bovine ([@ref-70]; [@ref-92]). Dual-labeled immunofluorescence ------------------------------- To investigate the possible interaction between GnRH-expressing cells and cells immunoreactive for RFRP-1/3 or kisspeptin, dual-immunofluorescence was performed. As stated above, sections were washed and incubated with the monoclonal antibody mouse anti-GnRH (1:3,000; SMI 41, Biolegend) and either rabbit antibody RFRP-1/RFRP-3 (1:10,000) or kisspeptin (1:10,000) for 48 h in PBTX at 4 °C. After primary incubations, sections were washed and incubated in Alexa Fluor 488 or Cy3 conjugated to donkey anti-rabbit or mouse IgG, respective to primary host. Sections processed to detect GnRH and kisspeptin were put through antigen retrieval as described above. Omission of one or both of the primary antibodies completely removed all corresponding staining. Tissue analysis --------------- The distribution of immunoreactive cells and fibers was examined in a series of every sixth section (50 µm thick each) through the preoptic area and hypothalamus of each animal. Images of labeled material were captured using a digital camera (QImaging Retiga 2000R) attached to a Nikon microscope (Eclipse E800M), and NIS-Elements software version 4.11 (Nikon). Images were imported into Adobe Photoshop CS6 (Adobe Systems) and were not altered in any way except for minor adjustments of brightness and contrast. The number of cells identified by immunohistochemistry for a nucleus/region was estimated by summing the total number of cells observed within the borders of each nuclei/region in three representative sections from each animal. Sections were atlas matched ([@ref-88]; [@ref-100]), and areas were identified by examining cresyl violet-stained tissue of alternate serial cut sections, under bright-field microscopy. GnRH fiber densities and intensity were evaluated by two ways. Fluorescent intensity was measured by arbitrary density units (ADU) above an established threshold. Fiber density was determined by examining the number of pixels in a defined area (250-µm^2^ square) to determine the degree of ME taken up by immunofluorescent fibers positive for GnRH. The fiber density value consisted of the area (in pixels) covered by labeled fibers divided by total area (in pixels) within the boundaries (Nikon Elements). The percentage of GnRH immunoreactive (-ir) cells with close apposition with kisspeptin or RFRP 1/3-ir processes were calculated. Each identified GnRH-ir soma was examined under a Nikon A1 confocal with an Eclipse
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66, 187 ]
8.453 0.044 8.451 0.042 51 4-NO~2~-Ph 8.6 8.066 8.024 −0.042 8.056 −0.010 52[^a^](#TN1){ref-type="table-fn"} 3-CONH~2~-Ph 5.1 8.292 8.087 −0.205 8.429 0.137 *Test set compounds used for 3D-QSAR models*. *The compounds used for pharmacophore models*. *CoMFA, comparative molecular field analysis; CoMSIA, comparative molecular similarity indices analysis; DHPY, dihydrofuro\[3,4-d\]pyrimidine; NNRTIs, non-nucleoside reverse transcriptase inhibitors*. To date, there are many computer-aided drug design methods applied in designing and developing novel HIV-1 inhibitors (Almerico et al., [@B2]). For example, the three-dimensional quantitative structure--activity relationship (3D-QSAR) and pharmacophore models were utilized to learn about structural characteristics of HIV-1 NNRTIs in our previous studies (Liu et al., [@B23]; Wan et al., [@B30]). The multivariate statistical procedures, containing principal component and discriminant analysis, could be as credible methods to predict the activities of HIV-1 inhibitors by taking advantage of the vast anti-HIV data (Almerico et al., [@B1], [@B4]). The molecular docking and molecular dynamics (MD) simulation were often used to understand the binding conformations of ligands in the active sites of HIV-1-related proteins. Furthermore, a comparative analysis with the combination of docking and multivariate methods was used to study the drug resistance of HIV-1 inhibitors and to further design new compounds with appropriate structural features (Almerico et al., [@B3]). To further explore the essential structural and pharmacological features of the novel DHPYs as HIV-1 NNRTIs in this study, the combination of 3D-QSAR models, molecular docking, and MD simulation was applied to analyze the 3D-QSARs of these DHPYs and their binding modes in the HIV-1 RT. We also utilized the pharmacophore- and docking-based virtual screening to obtain some hit compounds from ZINC database and subsequently designed new potential NNRTIs according to the screening and 3D-QSAR results. Molecular docking and MD simulations were utilized to identify the binding of these new NNRTIs and the stabilization of the protein--ligand complexes. Materials and Methods {#s2} ===================== Preparation of Small Molecules ------------------------------ A total of 52 DHPY derivatives were collected from the published literature (Kang et al., [@B18]) for performing the molecular modeling study. Their structures, EC~50~, and corresponding pEC~50~ (−log*EC*~50~) values were listed in [Table 1](#T1){ref-type="table"}. All compounds were stretched by SYBYL-X 2.1 (Tripos Inc., St. Louis, USA) running on Windows 7 workstation and minimized with Gasteiger--Hückel charges, the termination of 0.005 kcal/(mol·Å) and max iterations of 1,000 by Powell method. Other parameters were set to default values. Three-Dimensional Quantitative Structure--Activity Relationship Model --------------------------------------------------------------------- The 3D-QSAR model could help to find a significant correlation between the biological activities of drug molecules and their structures (Borisa and Bhatt, [@B5]). In this study, comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods were used to construct 3D-QSAR models. All compounds were randomly divided into a training set (39 compounds) to generate CoMFA and CoMSIA models and a test set (13 compounds) to confirm the reliability of the generated models ([Table 1](#T1){ref-type="table"}). The number of test set compounds should be kept in the range from 1/4 to 1/3 of the total compounds. Compound **36** with the highest activity was used as a template, and all training set compounds were superimposed on it by the common skeleton alignment ([Figure 2A](#F2){ref-type="fig"}). ![The molecular alignment using compound **36** as a template. **(A)** The alignment results of the training set compounds used for the three-dimensional quantitative structure--activity relationship (3D-QSAR) models. **(B)** The chemical structure of compound **36**, and the red region represents the common scaffold.](fchem-08-00164-g0002){#F2} For generating a reasonable model, the internal predictive ability was evaluated by partial least squares (PLS) regression method using the SAMPLS. The leave-one-out (LOO) cross-validation procedure was applied to determine the optimum number of components (ONC) and the highest cross-validation correlation coefficient (Q^2^) (Bush and Nachbar, [@B6]), and non-cross-validated analysis was applied to compute the non-cross-validated correlation coefficient (*R*^2^), standard error of estimate (SEE), and the Fisher test values (F) (Li et al., [@B20]). External validation parameters were also essential for further assessing the predictive capability of 3D-QSAR models, such as ${r_{0}}^{2}$, *k*, ${r_{0}}^{{}^{\prime}2}$, and *k*′. ${r_{0}}^{2}$, and *k* were the corresponding correlation coefficient and the slope value of linear regression equation, respectively, for predicted vs. actual activities when the intercept was set to zero, and ${r_{0}}^{{}^{\prime}2}$ and *k*′ were for actual vs. predicted activities, respectively. In addition, ${r_{m}}^{2}$, ${r_{m}}^{{}^{\prime}2}$, ${{\bigtriangleup r}_{m}}^{2}$, $\overline{{r_{m}}^{2}}$, and the root mean square error (RMSE) as traditional data were also calculated to appraise the predictive ability. A model, which met the requirements of $\left\lbrack {{({r^{2} - {r_{0}}^{2}})}/r^{2}} \right\rbrack$ or $\left\lbrack {{({r^{2} - {r_{0}}^{{}^{\prime}2}})}/r^{2}} \right\rbrack$ \< 0.1, 0.85 ≤ *k* ≤ 1.15 or 0.85 ≤ *k*′ ≤ 1.15, ${{\bigtriangleup r}_{m}}^{2}$ \< 0.2 and $\overline{{r_{m}}^{2}}$ \> 0.5, especially the predictive correlation ${r_{pred}}^{2}$ \> 0.6, would be deemed to possess well-predictive capability and reliability (Caballero, [@B7]; Ojha et al., [@B27]; Roy et al., [@B28]). The parameters were calculated according to our previous studies (Wang et al., [@B32]; Gao et al., [@B13]; Liu et al., [@B22]). Pharmacophore Model ------------------- Ten compounds ([Table 1](#T1){ref-type="table"}) with high activities and diverse structures were selected to generate pharmacophore model using Genetic Algorithm with Linear Assignment of Hypermolecular Alignment of Database (GALAHAD) module in SYBYL-X 2.1. GALAHAD method mainly contained two steps. The ligands are neatly aligned to each other in internal coordinate space, and then the produced conformations as rigid bodies are aligned in Cartesian space. In the process of running GALAHAD, the parameters of population size, max generation, and molecules required to hit were automatically set according to the experiment activity data. Finally, 20 models with diverse parameters including SPECIFICITY, N_HITS, STERICS, HBOND, and Mol_Qry were generated. In order to further validate the ability of the pharmacophore model, a decoy set method was used for evaluating the generated model. The decoy set database was comprised of 6,234 inactive compounds downloaded from the DUD-E database (<http://dud.docking.org/>) (Mysinger et al., [@B25]) and 42 active compounds from [Table 1](#T1){ref-type="table"} except the compounds used for constructing the pharmacophore model. The enrichment factor (EF) and Güner--Henry (GH) scores were considered as metrics to assess the reliability of the pharmacophore models. The GH score took the percent yield of actives in a hit list (%Y, recall) and the percent ratio of actives in a database (%A, precision) into account. While the GH score is ranging 0.6--1, the pharmacophore model would be regarded as a rational model (Kalva et al., [@B15]). \% Y = H a / H t × 100 \% \% A = H a / A × 100 \% E F = ( H a / H t ) / ( A / D ) G H = ( H a
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This was an observational study with its inherent limitations. The GUIDE-HF (hemodynamic-GUIDEd management of Heart Failure) trial is a randomized control trial in NYHA functional classes II--IV, which is ongoing and likely to show directions in the future if any improvement in mortality occurs with the CardioMEMS device. The GUIDE-HF investigational device exemption (IDE) trial will include approximately 3600 patients at approximately 140 sites and is expected to be completed by 2023. The study is intended to measure all-cause mortality and heart failure hospitalizations. A summary of the above-mentioned trials is shown in [Table 1](#table1-1753944719826826){ref-type="table"}. ###### Trials on implantable hemodynamic monitoring in heart failure patients. ![](10.1177_1753944719826826-table1) -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Name of trial Type of trial NYHA functional class Clinical endpoints Specific inclusion criteria Number of patients enrolled Duration of clinical trial ----- ---------------------------------------------- ------------------------------------------------------------------------------- ----------------------- ---------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------- ----------------------------- ---------------------------------------------- 1\. CHAMPION\ Double-blind, randomized control study III Reduction in hospitalization Diagnosis of HF for 3 months with preserved or reduced EF and BMI \< 35 kg/m^2^ 550 Until last enrolled patient reached 6 months trial^[@bibr30-1753944719826826]^ 2 PAPIRUS\ Prospective, multicenter phase I study III, IV Home monitoring of PAP was feasible, safe and accepted by patients in every day ambulatory conditions Age \> 18 years and followed regularly in HF clinic for 6 months 31 6 months trial^[@bibr39-1753944719826826]^ 3 REDUCE-HF trial^[@bibr41-1753944719826826]^ Prospective, multicenter, single-blind, randomized, parallel-controlled study II, III Use of a single chamber AICD with a hemodynamic monitoring system\ Age \> 18 years and eGFR \> 30 ml/min/m^2^ 850 12 months Primary endpoint was met but the rates of hospitalization and urgent care visits did not differ between groups 4 COMPASS-HF trial^[@bibr40-1753944719826826]^ Prospective, multicenter, single-blind randomized, parallel-controlled study III, IV Chronicle group had an insignificant 21% lower rate of all HF-related events compared with the control group Age \> 18 years and received optimal medical HF therapy for at least 3 months prior to enrollment 274 6 months 5\. GUIDE-HF trial\ Prospective, multicenter, single-blind randomized, parallel-controlled study II, III, IV Recurrent heart failure hospitalization; death from any cause Age \> 18 years; Diagnosis and treatment for HF (regardless of LVEF) for \>90 days 3600 5 years (ongoing)^[@bibr46-1753944719826826]^ -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- AICD, implantable cardioverter defibrillator; BMI, body mass index; EF, ejection fraction; eGFR, estimated glomerular filtration rate; HF, heart failure; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; PAP, pulmonary artery pressure. Conclusions and future directions {#section7-1753944719826826} ================================= The best solution for HF morbidity and mortality reduction is prevention through managing the conditions predisposing to HF such as diabetes mellitus, hypertension and ischemic heart disease. Further research on HF management and prevention strategies should be expanded and applied to sex-based factors and across different ethnicities. The transition in the healthcare model is now towards a reduction in HF hospitalizations to minimize HF treatment-related costs in order to mitigate the limited healthcare resources. There are some obstacles facing these goals, such as cost-effectiveness, medico-legal issues, security of patient's data and validation, which should be resolved. Self-management by patients had largely been unsuccessful because of the advanced age of HF patients and the complexity of treatment. The addition of self-management counseling to an educational intervention in patients with mild to moderate HF did not reduce HF hospitalizations or mortality. All strategies should still aim to minimize patient responsibility in monitoring. A multidisciplinary approach can reduce HF hospital admissions and improve quality of life and mortality. The generalizability of the CardioMEMS HF system results to most patients with NYHA class III HF is adequate, because of a significant reduction in HF hospitalization and very few contraindications. To date, CardioMEMS is the only device or intervention other than guideline-directed medical therapy that has been shown to impact congestive heart failure (CHF) readmission rates, and is expected to show a mortality benefit in the ongoing GUIDE-HF trial. The major restriction of device monitoring is in patients with stage IV or V chronic kidney disease due to the limited response to diuresis, even with high PA pressure. Children under 18 years were excluded in all these clinical trials. Another limitation will be the high cost of the CardioMEMS device which likely will come down in the near future. **Funding:** This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. **Conflict of interest statement:** The authors declare that there is no conflict of interest. **ORCID iD:** Puvanalingam Ayyadurai ![](10.1177_1753944719826826-img1.jpg) <https://orcid.org/0000-0001-7927-655X> Tag: Bitcoin Diamond Electrum For anybody who would like to venture into the world of virtual currencies, better known as cryptocurrencies, it will be required to have a virtual pocket or BitcoinWallet. In the virtual marketplace there are lots of these, but this time we wish to speak about a really popular one, the Electrum wallet; the best option for beginners and one of the best concerning security. 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Here the link: http://www.electrumdiamond.org/index.html#First death linked to romaine E. coli outbreak reported Justin Sullivan / Getty Images Federal health officials are advising consumers to throw away and avoid eating Romaine lettuce, especially if its origin is from Yuma, Ariz., as investigators try to figure out the cause of an E. coli outbreak that has killed one person and sickened 121 others. Federal health officials are advising consumers to throw away and avoid eating Romaine lettuce, especially if its origin is from Yuma, Ariz., as investigators try to figure out the cause of an E. coli outbreak that has killed one person and sickened 121 others. (Justin Sullivan / Getty Images) Health officials say the contamination so far has been traced to romaine lettuce grown in the area around Yuma, Ariz. — part of the growing region that produces 90% of the nation’s winter lettuce, and which has largely stopped growing the winter crop. Last week, the CDC said whole head romaine lettuce from Harrison Farms near Yuma has been linked to eight cases among prisoners in a Nome, Ala., detention facility. At least a dozen other locations are under scrutiny for possible links to the remaining cases, according to the Food and Drug Administration. The FDA is “examining all possibilities, including that contamination may have occurred at any point along the growing, harvesting, packaging, and distribution chain.” The FDA noted that
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3.40 2.33 −10.71[\*](#sms13431-note-0006){ref-type="fn"} 0.55 Norway 11‐year‐olds 718 3.22 2.10 583 3.96 2.12 −6.29[\*](#sms13431-note-0006){ref-type="fn"} 0.35 641 2.52 1.81 627 3.49 1.96 −9.12[\*](#sms13431-note-0006){ref-type="fn"} 0.51 13‐year‐olds 611 2.97 1.90 426 3.68 2.14 −5.49[\*](#sms13431-note-0006){ref-type="fn"} 0.35 689 2.67 1.87 476 3.36 1.94 −6.01[\*](#sms13431-note-0006){ref-type="fn"} 0.36 15‐year‐olds 666 3.03 2.11 393 3.80 2.37 −5.34[\*](#sms13431-note-0006){ref-type="fn"} 0.34 623 2.61 1.95 446 3.37 2.04 −6.17[\*](#sms13431-note-0006){ref-type="fn"} 0.38 Gender differences in 1985/1986 Finland: 11 y (*t* = 6.42, *P* \< 0.001, *d* = −0.38), 13 y (*t* = 7.32, *P* \< 0.001, *d* = −0.48), 15 y (*t* = 6.96, *P* \< 0.001, *d* = −0.42). Gender differences in 2014 Finland: 11 y (*t* = 2.51, *P* = 0.012, *d* = −0.11), 13 y (*t* = 1.08, ns), 15 y (*t* = −0.34, ns). Gender differences in 1985/1986 Norway: 11 y (*t* = 6.55, *P* \< 0.001, *d* = 0.36), 13 y (*t* = 2.86, *P* = 0.004, *d* = 0.15), 15 y (*t* = 3.74, *P* \< 0.001, *d* = 0.21). Gender differences in 2014 Norway: 11 y (*t* = 4.02, *P* \< 0.001, *d* = 0.23), 13 y (*t* = 2.36, *P* = 0.02, *d* = 0.16), 15 y (*t* = 2.82, *P* = 0.005, *d* = 0.19). *P* \< 0.001 John Wiley & Sons, Ltd Linear mixed model analysis was performed to establish whether LVPA differed according to country, gender, age group, participation in organized sports clubs, and survey year (Table [4](#sms13431-tbl-0004){ref-type="table"}). There were significant main effects of all independent variables. As shown in Table [5](#sms13431-tbl-0005){ref-type="table"}, the activity levels were generally higher in 2014, among boys, and among those in organized sports clubs. Inspection of the means in Table [5](#sms13431-tbl-0005){ref-type="table"} reveals that the effects of age and country were negligible, although statistically significant. With regard to difference over time, there was a two‐way interaction (Table [4](#sms13431-tbl-0004){ref-type="table"}) between survey year and participation in sports clubs on LVPA, indicating that the effect of participation in organized sports clubs differed across survey year. Table [5](#sms13431-tbl-0005){ref-type="table"} shows that this difference concerns a stronger association between participation in sports clubs and LVPA in 2014 compared to 1985/1986, that is in 2014, participants in sports clubs reported higher levels of LVPA compared to non‐participants than was the case in 1985/1986. There was a two‐way interaction effect of survey year and gender. The means depicted in Table [3](#sms13431-tbl-0003){ref-type="table"} suggest that this effect is due to the relatively steeper increase over time in LVPA among girls compared to boys. Figure [1](#sms13431-fig-0001){ref-type="fig"} illustrates the significant three‐way interaction effect between participation in organized sports clubs, country, and survey year on LVPA shown in Table [4](#sms13431-tbl-0004){ref-type="table"}. In Finland, the increase in the association between participation and LVPA over time was less pronounced than in Norway. Figure [2](#sms13431-fig-0002){ref-type="fig"} illustrates the three‐way interaction between gender, country, and survey year. From 1985/1986 to 2014, the effect of gender on LVPA changed more in Finland than in Norway, indicated by a steeper increase in activity among Finnish girls. ###### Univariate analysis of variance testing interaction effects of gender, age group, participation in organized sports clubs, and survey year on times per week in leisure‐time vigorous physical activity (N = 14 760) Variable Numerator *df* Denominator *df* *F* *P* --------------------------------------------- ---------------- ------------------ ---------- --------- Intercept 1 838.19 20623.90 \<0.001 Survey year (Y) 1 838.19 187.44 \<0.001 Gender (G) 1 14599.62 116.55 \<0.001 Age group (A) 2 866.92 16.42 \<0.001 Participation in organized sports clubs (P) 1 14626.74 2588.11 \<0.001 Country (C) 1 838.19 7.28 0.007 Y \* G 1 14599.62 24.88 \<0.001 Y \* A 2 866.92 2.10 0.123 Y \* P 1 14626.74 27.94 \<0.001 Y \* C 1 838.19 2.13 0.145 G \* A 2 14596.74 1.18 0.307 G \* P 1 14696.66 5.94 0.015 G \* C 1 14599.62 3.05 0.081 A \* P 2 14629.69 49.88 \<0.001 A \* C 2 866.92 6.74 0.001 P \* C 1 14626.74 10.84 0.001 Y \* G \* A 2 14596.74 0.31 0.733 Y \* G \* P 1 14696.66 2.55 0.110 Y \* G \* C 1 14599.62 14.38 \<0.001 Y \* A \* P 2 14629.69 1.41 0.245 Y \* A \* C 2 866.92 0.32 0.725 Y \* P \* C 1 14626.74 13.05 \<0.001 G \* A \* P 2 14696.65 0.83 0.435 G \* A \* C 2 14596.74 1.99 0.137 G \* P \* C 1 14696.66 0.15 0.699 A \* P \* C 2 14629.69 4.16 0.016 Y \* G \* A \* P 2 14696.65 0.83 0.435 Y \* G \* A \* C 2 14596.74 1.41 0.243 Y \* G \* P \* C 1 14696.66 1.88 0.170 Y \* A \* P \* C 2 14629.69 2.17 0.114 G \* A \* P \* C 2 14696.65 0.88
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with out worry of getting pulled over so that didn't last long, but it read accurately. I'll start looking for programmers and see what the money flow states as to purchasing. This forum is owned and operated by Internet Brands, Inc., a Delaware corporation. It is not authorized or endorsed by the Ford Motor Company and is not affiliated with the Ford Motor Company or its related companies in any way. FordŽ is a registered trademark of the Ford Motor Company<?php /** * class Rss * Rss generator * * @author xw */ class Rss { /** * rss channel array * @var array $channel * @access public */ public $channel = array(); /** * rss item array * @var array $items * @access public */ public $items = array(); /** * required channel elements * @var array $_channel * @access private */ private $_channel = array("title", "link", "description"); /** * optional channel elements * @var array $_channelTag * @access private */ private $_channelTag = array("language", "generator", "lastBuildDate", "copyright", "managingEditor", "webMaster", "pubDate", "category", "docs", "cloud", "ttl", "image", "rating", "textInput", "skipHours", "skipDays"); /** * optional item elements * @var array $_itemTag * @access private */ private $_itemTag = array("title", "link", "author", "pubDate", "guid", "comments", "description", "enclosure", "source"); /** * rss version * @var string $_version * @access private */ private $_version = "2.0"; /** * rss encode * @var string $_encoding * @access private */ private $_encoding = "gb2312"; /** * function __construct * * @param array $c channel data * @param array $i item data * @return Rss object * @access public * @throws RssException */ public function __construct($c, $i = array()){ if(!is_array($c) || !is_array($i)) throw new RssException(); $keys = array_keys($c); foreach($this->_channel as $v){ if(!in_array($v, $keys)) throw new RssException(); } $this->channel = $c; $this->items = $i; } public function getRss(){ $ret = ""; $ret .= $this->_getHeader(); $ret .= $this->_getChannel(); $ret .= $this->_getItems(); $ret .= $this->_getFooter(); return $ret; } private function _getChannel(){ $ret = ""; foreach($this->channel as $k => $v){ if(!in_array($k, $this->_channelTag) && !in_array($k, $this->_channel)) continue; if($k === "lastBuildDate" || $k === "pubDate") $v = gmdate("D, d M Y H:i:s", $v) . " GMT"; $ret .= "\n\t\t<$k>$v</$k>"; } return $ret; } private function _getItems(){ $ret = ""; foreach($this->items as $item){ if(is_array($item)){ $ret .= "\n\t\t<item>"; foreach($item as $k => $v){ if(!in_array($k, $this->_itemTag)) continue; if($k === "pubDate") $v = gmdate("D, d M Y H:i:s", $v) . " GMT"; $ret .= "\n\t\t\t<$k>$v</$k>"; } $ret .= "\n\t\t</item>"; } } return $ret; } private function _getHeader(){ return <<<EOT <?xml version="1.0" encoding="{$this->_encoding}" ?> <rss version="{$this->_version}"> <channel> EOT; } private function _getFooter(){ return <<<EOD \n </channel> </rss> EOD; } } class RssException extends Exception{} Q: Redirecting a url with a shtml extension to a php extension with htacess I have many old .shtml files in a subdomain of my main site that have been updated. The updated files are however, php files that have the same names of the original files and are also in the same location. for example /processing/myfile.shtml is the old version of /processing/myfile.php I'd like to ensure that when a visitor tries to access the .shtml file that they are redirected to the equivalent .php file. I have been informed that I can only do this through htaccess as I am utilizing shared hosting. However adding the following to htaccess does not work RewriteCond %{HTTP_HOST} ^processing\.lyndondaniels\.com$ [OR] RewriteCond %{HTTP_HOST} ^www\.processing\.lyndondaniels\.com$ RewriteRule ^(.*)\.shtml$ "http\:\/\/processing\.lyndondaniels\.com\/$1.php" [R=301,L] I'm kinda just winging it as I'm unfamilliar with the syntax, so I'd appreciate it if you could provide me with a working example. thanks! A: Try this: RewriteRule ^(.*)\.shtml$ "http://%{HTTP_HOST}/$1.php" [R=301,L] Search www.sgs.fi Chemical Product Composition Analysis SGS has decades of experience of assisting clients across the globe with verification of the composition of their cosmetic products. Our product composition analysis gives you the peace of mind that a comprehensive examination of your products has been carried out and ingredients verified by industry experts – which reduces the possibility of your product being stalled as you launch it locally or transport it to new markets with different regulatory requirements. Working with samples of your finished product, we validate the dosage of relevant components including: Allergens Preservatives Active ingredients Prohibited substances The solvents ethanol, isopropanol, glycol, acetone, and methanol Depending on the nature of your product, we can also analyze using the following parameters: Appearance Color Odor Volume, mass and density pH Dry extract Water content Acid and peroxide index Saponification value and unsaponifiables Melting and flash point IR spectrum Sterol fraction Fatty acid composition Chromatographic profile Solubility and insolubility in isopropanol For aerosols: Aerosol flow Propellant type and content Pressure Our consultants can advise on tests that are relevant to your product. Contact us today to learn how we can help with your product.The husband of a Sudanese woman sentenced to death for converting to Christianity says he will appeal against the ruling. Mariam Yahya Ibrahim Ishag had been ordered to abandon her newly adopted Christian faith and return to Islam. She had also been charged with adultery for marrying a Christian man. Her husband, Daniel Wani, was pronounced innocent but their marriage was revoked. Ishag says she was born to a Sudanese Muslim father, who was absent, and raised by an Ethiopian Christian mother. Wani was quoted as saying on Saturday he would appeal against the decision. "I was considered innocent and the marriage revoked - the revoking of this marriage means that my son is no longer my son and the one coming is not my son too, will not be my son - so this innocence means nothing and I will appeal for myself and I will appeal for my wife," the Reuters news agency reported. Wani said he feared for the health of his wife and their unborn son while she is kept in a prison cell. "Martin [my son] and my wife, they are all in prison and she is pregnant - she could give birth at any time, from today to 1st of June, she may give birth. I am afraid that being in prison is dangerous for her so if they would allow me to take her to the hospital that she delivered Martin in - even if it was under the watch of security guards, I
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intended to do. "What if he doesn't handle it very well?" I asked. "Then," my friend replied, "you're going to have to handle it well." "What if's" can make us crazy. They put control over our life in someone else's hands. "What if's" are a sign that we have reverted to thinking that people have to react in a particular way for us to continue on our course. "What if's" are also a clue that we may be wondering whether we can trust ourselves and our Higher Power to do what's best for us. These are shreds of codependent ways of thinking, feeling, and behaving, and they signal fear. The reactions, feelings, likes or dislikes of others don't have to control our behaviors, feelings, and direction. We don't need to control how others react to our choices. We can trust ourselves, with help from a Higher Power, to handle any outcome—even the most uncomfortable. And, my friend, we can trust ourselves to handle it well. Today, I will not worry about other people's reactions, or events outside of my control. Instead, I will focus on my reactions. I will handle my life well today and trust that, tomorrow, I can do the same. ### June # June Directness: June 1 We feel safe around direct, honest people. They speak their minds, and we know where we stand with them. Indirect people, people who are afraid to say who they are, what they want, and what they're feeling, cannot be trusted. They will somehow act out their truth even though they do not speak it. And it may catch everyone by surprise. Directness saves time and energy. It removes us as victims. It dispenses with martyrdom and games. It helps us own our power. It creates respectful relationships. It feels safe to be around direct, honest people. Be one. Today, I will own my power to be direct. I do not have to be passive, nor do I need to be aggressive. I will become comfortable with my own truth, so those around me can become comfortable with me. Owning Our Power: June 2 We don't have to give others so much power and ourselves so little. We don't have to give others so much credit and ourselves so little. In recovery from codependency, we learn there's a big difference between humility and discounting ourselves. When others act irresponsibly and attempt to blame their problems on us, we no longer feel guilty. We let them face their own consequences. When others talk nonsense, we don't question our own thinking. When others try to manipulate or exploit us, we know it's okay to feel anger and distrust and to say no to the plan. When others tell us that we want something that we really don't want, or someone tells us that we don't want something that we really do want, we trust ourselves. When others tell us things we don't believe, we know it's okay to trust our instincts. We can even change our mind later. We don't have to give up our personal power to anyone: strangers, friends, spouses, children, authority figures, or those over whom we're in authority. People may have things to teach us. They may have more information than we have, and may appear more confident or forceful than we feel. But we are equals. Our magic is not in them. Our magic, our light, is in us. And it is as bright a light as theirs. We are not second-class citizens. By owning our power, we don't have to become aggressive or controlling. We don't have to discount others. But we don't discount ourselves either. Today, I will own my power with people. I will let myself know what I know, feel what I feel, believe what I believe, and see what I see. I will be open to changing and learning from others and experience, but I will trust and validate myself too. I will stand in my own truth. Charity: June 3 We need healthy boundaries about receiving money, and we need healthy boundaries about giving money. Some of us give money for inappropriate reasons. We may be ashamed because we have money and don't believe we deserve it. We may belong to an organization that uses shame as a form of control to coerce us out of our money that the organization wants. We can get hooked into giving money to our children, family members, or friends because we have earned or unearned guilt. We allow ourselves to be financially blackmailed, sometimes by the people we love. This is not money freely given, or given in health. Some of us give money out of a sense of caretaking. We may have exaggerated feelings of responsibility for others, including financial responsibility. We may be giving simply because we have not learned to own our power to say no when the answer is _no._ Some of us give because we hope or believe people will love us if we take care of them financially. We do not _have_ to give money to anyone. Giving money is our choice. We do not have to allow ourselves to be victimized, manipulated, or coerced out of our money. We are financially responsible for ourselves. Part of being healthy is allowing those around us to be financially responsible for themselves. We do not have to be ashamed about having the money that we earn; we deserve to have the money we have been given—whatever the amount, without feeling obligated to give it all away, or guilty because others want what we have. Charity is a blessing. Giving is part of healthy living. We can learn to develop healthy boundaries around giving. Today, I will strive to begin developing healthy boundaries about giving money. I understand that giving is my choice. Trusting God: June 4 A married couple, friends of mine, decided to make some changes in their living situation. They had always lived in the city, and now they decided they wanted to live in the country, on a lake. They found a small lake home. It wasn't the house of their dreams, but when they sold their city home, they would have money to remodel it. They had saved some money, so they moved into their lake home before selling their city home. One year passed, and the city home didn't sell. My friends went through many changes during this time. They had times of patience and impatience. Some days they trusted God; other days they couldn't figure out why God was making them wait so long, why God wouldn't let them move forward with their plan. The doors just wouldn't swing wide open. One day, a neighbor came to visit my friends. His home on the lake was my friends' dream home—everything they wanted, plus more. The first time my friends saw this house, they admired it, wishing they could have a home just like it, but then they forgot about the idea. They didn't believe it could ever be possible. The reason the neighbor came to visit my friends was that he and his wife had decided to move. He offered my friends the first option on purchasing his home. My friends accepted his offer, and signed a purchase agreement. Within two months, they sold their city home and their small but adequate lake home. A short time later, they moved into the home of their dreams. Sometimes, we experience times of frustration in our life. We believe we're on track, trusting God and ourselves, yet things don't work out. We have false starts and stops. The door refuses to swing wide open. We may wonder if God has abandoned us, or doesn't care. We may not understand where we're going, or what our direction is. Then one day we see: the reason we didn't get what we wanted was because God had something much better planned for us. Today, I will practice patience. I will ask, and trust, my Higher Power to send me His best. Combating Shame: June 5 _Shame can hold us back, hold us down, and keep us staring at our feet._ —Beyond Codependency Watch out for shame. Many systems and people reek of shame. They are controlled by shame and may want us to play their game with them. They may be hoping to hook us and control us through shame. We don't have to fall into their shame. Instead, we'll take the good feelings—self-acceptance, love, and nurturing. Compulsive behaviors, sexually addictive behaviors, overeating, chemical abuse, and addictive gambling are shame-based behaviors. If we participate in them, we will feel ashamed. It's inevitable. We need to watch out for addictive and other compulsive behaviors because those will immerse us in shame. Our past, and the brainwashing we may have had that imposed "original shame" upon us, may try to put shame on us. This can happen when we're all alone, walking through the grocery store or just quietly going about living our life. Don't think.... Don't feel.... Don't grow or change.... Don't be alive.... Don't live life.... Be ashamed! Be done with shame. Attack shame. Go to war with it. Learn to recognize it and avoid it like the plague. Today, I will deliberately refuse to get caught up in the shame floating around in the world. If I cannot resist it, I will feel it, accept it
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among the groups. With a median follow-up after surgery of 72 months, the 5- and 10-year DSSs for all patients were 84 and 69 %, respectively. The predictors of survival were age (p = 0.004), symptoms at the time of presentation (p = 0.045), histology (p = 0.01), sites of metastasis (p = 0.03), and (131)I avidity and sTg level at the time of metastasis (p = 0.002). In the multivariate analysis, age, histology, and (131)I avidity and sTg level at the time of metastasis remained significant factors for survival. Certain DTC patients with distant metastasis demonstrate favorable outcomes dependent on age, histology, and (131)I avidity and sTg level at the time of metastasis.package acr.browser.lightning.database.bookmark; import android.content.Context; import android.os.Environment; import android.util.Log; import org.json.JSONException; import org.json.JSONObject; import java.io.BufferedReader; import java.io.BufferedWriter; import java.io.File; import java.io.FileWriter; import java.io.IOException; import java.io.InputStream; import java.io.InputStreamReader; import java.util.ArrayList; import java.util.List; import acr.browser.lightning.R; import acr.browser.lightning.database.Bookmark; import acr.browser.lightning.database.WebPageKt; import acr.browser.lightning.utils.Preconditions; import acr.browser.lightning.utils.Utils; import androidx.annotation.NonNull; import androidx.annotation.WorkerThread; import io.reactivex.Completable; /** * The class responsible for importing and exporting * bookmarks in the JSON format. * <p> * Created by anthonycr on 5/7/17. */ public final class BookmarkExporter { private static final String TAG = "BookmarkExporter"; private static final String KEY_URL = "url"; private static final String KEY_TITLE = "title"; private static final String KEY_FOLDER = "folder"; private static final String KEY_ORDER = "order"; private BookmarkExporter() {} /** * Retrieves all the default bookmarks stored * in the raw file within assets. * * @param context the context necessary to open assets. * @return a non null list of the bookmarks stored in assets. */ @NonNull public static List<Bookmark.Entry> importBookmarksFromAssets(@NonNull Context context) { List<Bookmark.Entry> bookmarks = new ArrayList<>(); BufferedReader bookmarksReader = null; InputStream inputStream = null; try { inputStream = context.getResources().openRawResource(R.raw.default_bookmarks); //noinspection IOResourceOpenedButNotSafelyClosed bookmarksReader = new BufferedReader(new InputStreamReader(inputStream)); String line; while ((line = bookmarksReader.readLine()) != null) { try { JSONObject object = new JSONObject(line); final String folderTitle = object.getString(KEY_FOLDER); bookmarks.add( new Bookmark.Entry( object.getString(KEY_URL), object.getString(KEY_TITLE), object.getInt(KEY_ORDER), WebPageKt.asFolder(folderTitle) ) ); } catch (JSONException e) { Log.e(TAG, "Can't parse line " + line, e); } } } catch (IOException e) { Log.e(TAG, "Error reading the bookmarks file", e); } finally { Utils.close(bookmarksReader); Utils.close(inputStream); } return bookmarks; } /** * Exports the list of bookmarks to a file. * * @param bookmarkList the bookmarks to export. * @param file the file to export to. * @return an observable that emits a completion * event when the export is complete, or an error * event if there is a problem. */ @NonNull public static Completable exportBookmarksToFile(@NonNull final List<Bookmark.Entry> bookmarkList, @NonNull final File file) { return Completable.fromAction(() -> { Preconditions.checkNonNull(bookmarkList); BufferedWriter bookmarkWriter = null; try { //noinspection IOResourceOpenedButNotSafelyClosed bookmarkWriter = new BufferedWriter(new FileWriter(file, false)); JSONObject object = new JSONObject(); for (Bookmark.Entry item : bookmarkList) { object.put(KEY_TITLE, item.getTitle()); object.put(KEY_URL, item.getUrl()); object.put(KEY_FOLDER, item.getFolder().getTitle()); object.put(KEY_ORDER, item.getPosition()); bookmarkWriter.write(object.toString()); bookmarkWriter.newLine(); } } finally { Utils.close(bookmarkWriter); } }); } /** * Attempts to import bookmarks from the * given file. If the file is not in a * supported format, it will fail. * * @param inputStream The stream to import from. * @return A list of bookmarks, or throws an exception if the bookmarks cannot be imported. */ @NonNull public static List<Bookmark.Entry> importBookmarksFromFileStream(@NonNull InputStream inputStream) throws Exception { BufferedReader bookmarksReader = null; try { //noinspection IOResourceOpenedButNotSafelyClosed bookmarksReader = new BufferedReader(new InputStreamReader(inputStream)); String line; List<Bookmark.Entry> bookmarks = new ArrayList<>(); while ((line = bookmarksReader.readLine()) != null) { JSONObject object = new JSONObject(line); final String folderName = object.getString(KEY_FOLDER); final Bookmark.Entry entry = new Bookmark.Entry( object.getString(KEY_URL), object.getString(KEY_TITLE), object.getInt(KEY_ORDER), WebPageKt.asFolder(folderName) ); bookmarks.add(entry); } return bookmarks; } finally { Utils.close(bookmarksReader); } } /** * A blocking call that creates a new export file with * the name "BookmarkExport.txt" and an appropriate * numerical appendage if a file already exists with * that name. * * @return a non null empty file that can be used * to export bookmarks to. */ @WorkerThread @NonNull public static File createNewExportFile() { File bookmarksExport = new File( Environment.getExternalStoragePublicDirectory(Environment.DIRECTORY_DOWNLOADS), "BookmarksExport.txt"); int counter = 0; while (bookmarksExport.exists()) { counter++; bookmarksExport = new File( Environment.getExternalStoragePublicDirectory(Environment.DIRECTORY_DOWNLOADS), "BookmarksExport-" + counter + ".txt"); } return bookmarksExport; } } 本連載では、教員を目指す大学生の2人が感じた「画一的な内容を一斉授業で教える」旧来の公教育に対する疑問と、今後求められる「学びの大転換」の参考として、日本の教育の形が当たり前ではない世界各国の教育トレンドを実地調査した内容をお伝えしていきます。第3回では、オランダの中高一貫校を視察して得られた気づきをご紹介します。 前回に対するフィードバックと筆者たちの考え 連載第2回の『オランダのコー�
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skin. Had I the chance, I’d have tanned her arse with an iron poker.’ A hot flush passed through my body. My vision began to blur. Wayland the Smith shook his massive head. ‘But she was one of us wasn’t she?’ I said (and I was going for it then, taking it all the way), ‘one of us poor forgotten buggers left alone in the dark.’ The eulogy had been cruel when I wrote it, in the swaying plastic toilet of a Leicestershire train. I’m not sure why I volunteered to speak. I suppose it was ego. Relief that my name still carried some sway. Shortly after its completion – and I had damned her, torn her into shreds with a neat little slip of my pen – a feeling settled within me that I could not fully identify. It was wider than loss, more consummate somehow. Before I could stop myself, I was shelling out for overpriced Mars Bars and German beer, mourning the loss of a blue-faced crone as the countryside swept up around me. I threw out the script. Decided to wing it instead. It would not be popular I knew, to stand up and rave, spewing half-developed rubbish about the long, inglorious fade. I wasn’t bothered. The booze did its job throughout the recital, dragging me down some magnificent umbilical towards the halls of inebriate glory. ‘Bollocks to it!’ I cried. ‘Bollocks to all this elf-pride heritage rubbish!’ And then Tom was there, at the back of the crowd, just as the story required. I wondered how long he had waited outside, wrestling with his faultless solitude. I wondered how long he had fought to keep Vivian from his mind. Was he thinking about the way her back arched when she slept? How she sang, sloppy and passionate, through the crack in the bathroom door? He touched his nose and slipped outside. I suppose I should have been angry, but what would it have mattered? Annie was dead. Vivian was gone. A rotund pastor tinkered with a stereo. A thin, dark woman began to wail. I leaned across the podium and drooled. ‘Did anyone else think that the last Blur album was a massive bag of shit? I’ll say one thing for old Iron Claws – she had some fucking taste!’ In ancient Greece, anything that was not a comedy was considered a tragedy instead. A kobaloi told me that. <*> The door swings noiselessly as Kelly enters the pub. She slides into a chair, working to sweep the hair above her ears back into place. This she does, according to her profile, because of a fear that they are overtly tiny. And they are. She says hello, smelling faintly of something floral. ‘Alright,’ I reply. Our second date begins. The Greenhouse is haunted, like all its clientele. I can no longer recall how long I might have been slumming beneath its roof. On occasion, I indulge myself the notion that I have always been here, am still here in thirty-odd years. This is the Greenhouse;cheap drinks and mediocre landscape. Layer upon layer of surface. Kelly has her thirty years all mapped out. Red wine and Netflix. Holidays in Spain. She is working under the assumption that I am a labourer by day, an invention whose success hinges entirely upon my assumption that it is far too bland to discuss. In a minute, I will inform her that I am in fact, a legendary slayer of giants. I will explain my interest in her as the product of … I don’t know, whatever it is that stirs within age-old bastards when their demented kin start jumping off bridges. If that works, I suppose I’ll ask her what her favourite cheeses are. She prods at the nylon frond that sits between us on the table. I stand up and get the beers in. <*> Wayland asked me if I was headed back home after the funeral. I told him that I was out of the game, that it wasn’t what he was thinking. He shook his head sadly and took me by the hand. ‘Everybody forgets,’ he said. ‘It is the curse of people.’ John felt differently. ‘Dereliction of duty,’ he said, swigging from a hip flask. ‘Takes the piss is what it does.’ I couldn’t really see his problem. He didn’t say much to me after that. Nobody did. <*> ‘It’s not like he means to do it,’ I say. ‘He doesn’t really think about relationships in that way. It’s just a good time for him.’Kelly shrugs. ‘Maybe there’s a reason for it.’ ‘Oh, trust me,’ I say, ‘there’s nothing going on with Tom.’ We are three pints in and I have yet to mention the giants. I am instead jabbering on about that bell-end Tom Hickathrift. About how he knobbed his way around the island of eels and never worked a day in his life. How he used up Vivian – I don’t mention her name – and threw her away when he was done. I want to tell her about his trip through Wisbech, about the football he kicked to the moon. How his mouth is cold and sensuous; his skin like permanent silk. I wonder how she would feel if I told her that my singular appeal has already been bettered by perfect Tom.I scratch my beard and stare into my glass. ‘Sorry,’ I say. ‘I’m not usually so full-on about people I know.’ She smiles, rolls her eyes. ‘It’s cool,’ she says. ‘You’re really not being that mental. Relationships fuck everybody up right?’ I try to return her smile. I am thinking about the time I laid down with a cobbler’s daughter in the Suffolk hills after killing a humpbacked giant. I told her about the magic trumpet I used to slay Galligantus, and only realised later the euphemistic power of the phrase. Is that a relationship then? Should I tell Kelly about the trumpet? I don’t know. It used to be I had Vivian to help me. ‘You’re probably right,’ I say. ‘It’s just … I suppose I’ve not had much experience in the whole dating thing of late.’ Kelly puts her drink on the table. ‘I know what you mean,’ she says. ‘You set out your defences, and try to dodge the right bullets, and it all goes wrong half the time anyway … ’ She curls her fingers as the words trail away. ‘I’m having a cynical one aren’t I?’ she says. ‘Sorry. I mean, it’s nice to think about people doing the things you hear about in songs – throwing roses in the rain and all that stuff – but nobody really does it. We try to live up to all this mythical stuff about how a date should be, or how a relationship should be, but it’s all just the same massive lie isn’t it?’ Shit. She disappears to the bar and returns with a bag of nuts. ‘Here,’ she says, skimming the ingredients. ‘A healthy snack, good for the bones. Free from all pretension.’ Outside the loo, a tiny woman is selling plastic roses. She might have some gnome-ish blood in her veins. Above her head, the words London Pork, Cumberland Ring are scrawled in chalk upon a blackboard. Kelly sniggers and I follow suit, surprised to find my doubt so readily slip away. To look up then, at the plastic vines that covet the ceiling, at the artificial tree and the long wooden beams. All of it is just for show, and somewhere hidden is the heart. <*> She emails in the morning to say how much she enjoyed the evening. I respond after lunch, composing my reply whilst scanning the local news. The café is cold and grey, indistinguishable from so many I have visited. Girls in white aprons move clumsily behind the counter, their disinterest as routine as their half-arsed cleaning. I swig my beer and paste another blob of data into the notepad. Monotonous piano notes tumble from a speaker, lending my investigation all the thrilling ambience of a trawl through a discount warehouse. Wayland was right. A quick scan of the forum confirms the possibility. It’s all they’ve been talking about. Rose has linked reports of disappearing animals. Rowland has chimed in with photos. John has said nothing, and in doing so has said it all. They are waiting for my reply. Waiting to see if twenty years has dulled the taste of that first defeat. Laughing behind their hands. I check and recheck the photos. Three murky pictures of sodden Cornish mud. If you didn’t know what to look for, you’d never see the footprints. I return to Kelly’s message. She is telling me about a book she is reading, chock full of wizards and beasts and epic romance. She tells me she once told the Prince of Wales to watch her bike while she went to use the loo, completely failing to register his royal aura until a
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--------- void omfpubdumphash(HASHREC **syms) { int i; SYM *sp; for (i = 0; i < HASHTABLESIZE; i++) { if ((sp = (SYM*)syms[i]) != 0) { while (sp) { if (sp->storage_class == sc_global && !(sp ->value.classdata.cppflags &PF_INLINE)) { omfputpub(sp); } if (sp->storage_class == sc_defunc) { SYM *sp1 = sp->tp->lst.head; while (sp1) { if (sp1->storage_class == sc_global && !(sp ->value.classdata.cppflags &PF_INLINE)) { omfputpub(sp1); } sp1 = sp1->next; } } if (sp->storage_class == sc_namespace && !sp ->value.classdata.parentns->anonymous) omfpubdumphash(sp->value.classdata.parentns->table); sp = sp->next; } } } } //------------------------------------------------------------------------- void omfPublics(void) { SYM *sp; LIST *lf = localfuncs; int i; omfpubdumphash(gsyms); while (lf) { SYM *sp = lf->data; if (sp->storage_class == sc_global && !(sp->value.classdata.cppflags &PF_INLINE)) { omfputpub(sp); } lf = lf->link; } for (i = 0; i < HASHTABLESIZE; i++) { struct _templatelist *tl; if ((tl = (struct templatelist*)templateFuncs[i]) != 0) { while (tl) { if (tl->sp->value.classdata.templatedata->hasbody && tl ->finalsp) { omfputpub(tl->finalsp); } tl = tl->next; } } } } //------------------------------------------------------------------------- void omfputexport(SYM *sp) { char buf[512], obuf[512]; int l; putsym(buf, sp, sp->name); l = strlen(buf); *(short*)obuf = 0xa000; obuf[2] = 2; // export obuf[3] = 0; // export flags obuf[4] = l; strcpy(obuf + 5, buf); buf[5+l] = l; strcpy(obuf + 6+l, buf); emit_record(COMENT, obuf, 6+2 * l); } //------------------------------------------------------------------------- void omfExports(void) { SYM *sp; int i; LIST *lf = localfuncs; while (lf) { sp = lf->data; if (sp->storage_class == sc_global && sp->mainsym->exportable && !(sp->value.classdata.cppflags & PF_INLINE)) { omfputexport(sp); } lf = lf->link; } for (i = 0; i < HASHTABLESIZE; i++) { if ((sp = (SYM*)((SYM **)gsyms)[i]) != 0) { while (sp) { if (sp->storage_class == sc_global && sp->mainsym->exportable) { omfputexport(sp); } if (sp->storage_class == sc_defunc) { SYM *sp1 = sp->tp->lst.head ; while (sp1) { if (sp1->storage_class == sc_global && sp1->mainsym->exportable && !(sp1->value.classdata.cppflags & PF_INLINE)) { omfputexport(sp1); } sp1 = sp1->next; } } sp = sp->next; } } } } //------------------------------------------------------------------------- void omfPassSeperator(void) { char buf[3]; buf[0] = 0x40; buf[1] = 0xa2; buf[2] = 0x01; emit_record(COMENT, buf, 3); } //------------------------------------------------------------------------- int omfFixups(int seg, EMIT_LIST *rec, char *data, char *buf, int *len) { int indent = 0, pos = 0; int fixeddat = FALSE; FIXUP *fixups = rec->fixups; while (fixups) { SYM *sp; int rel = FALSE, iseg; int fixdat = 0, tdat; int offset = fixups->address - rec->address; int locat = (offset >> 8) + (offset << 8); int segrel = FALSE; switch (fixups->fmode) { case fm_relsymbol: rel = TRUE; case fm_symbol: if (fixups->sym->storage_class == sc_abs) { if (rel) DIAG("Relative absolute in omfFixups"); else *(int*)(rec->data + offset) += sp->mainsym->offset; continue; } iseg = omfgetseg(fixups->sym); { SYM *sp = fixups->sym; if (sp->mainsym) sp = sp->mainsym; if (sp->storage_class == sc_member && sp ->value.classdata.gdeclare && sp ->value.classdata.gdeclare->storage_class == sc_global) sp = sp->value.classdata.gdeclare; if (sp->storage_class == sc_global || sp->storage_class == sc_static || (sp->storage_class == sc_external || sp ->storage_class == sc_externalfunc) && !sp->mainsym ->extflag) { if (rel) { if (iseg == seg) { *(int*)(data + offset) = sp->mainsym->offset - fixups->address - 4; } else { locat |= 0xa4; fixdat = 0x54; if (!(iseg &0xc0000000)) tdat = segxlattab[iseg]; else tdat = iseg; segrel = TRUE; *(int*)(data + offset) = sp->mainsym->offset; } } else { locat |= 0xe4; fixdat = 0x04; if (!(iseg &0xc0000000)) tdat = segxlattab[iseg]; else tdat = iseg; // printf("%s:%x:%x:%p:%p\n",sp->name,sp->offset,sp->mainsym->offset,sp,sp->mainsym) ; *(int*)(data + offset) += sp->mainsym->offset; segrel = TRUE; } /* segment relative */ } else { if (rel) { locat |= 0xa4; fixdat = 0x56; tdat = sp->value.i; } else { locat |= 0xe4; fixdat = 0x06; tdat = sp->value.i; } /* extdef relative */ } } break; case fm_rellabel: rel = TRUE; case fm_label: iseg = LabelSeg(fixups->label); if (rel) { if
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, que va a seure allà. Què està passant? El meu programa sembla estar encallat en quina línia, què li diries? >> Així que en realitat és atrapat en la línia 7. I no hem vist això abans, però en la línia 7, hi ha, de nou, aquesta declaració, obtenir cadena. I fa el que diu. S'espera ara per a l'ésser humà per prendre la corda. Això és completament intuïtiu per a mi, l'ésser humà, ja que no he estat informat el que ha de fer. >> Però m'ho dius anar per davant en la fe i m'ho dius a mi pretenc ser Rob. Intro. Aquest no és el programa del que pretenia. Així que tenim el nostre primer blog. >> Però anem a tractar de raonar a través per què aquest és el cas. En primer lloc, anem a solucionar aquest problema primer. Voldria afegir aquí una línia que diu: printf, quin és el seu nom? Farem prop de cotització, tancar parèntesi. >> Ara vaig a tornar a executar el programa. Problema. No estic veient això. >> Dreta. No tornar a compilar. Així que en un llenguatge com C, ja que canviar el codi font no significa Korean: 실제로 다시 정의 실행 경우에, 그냥 거기에 앉아거야. 무슨 일이야? 내 프로그램에 붙어있는 것 같다 어떤 라인, 당신은 말할 것? >> 그래서 실제로 7 호선에 붙어있어. 그리고 우리는 전에 본 적이 있지만 한 7 행에서, 이것은 다시 거기 문은 문자열을 얻는다. 그리고 그것이 말하는 않습니다. 그것은 인간의 지금 기다리고 문자열을 가지고 있습니다. 이것은 나에게 완전히 직관적이다 인간은, 내가 말되지 않았기 때문에 무엇을. >> 그러나 내가 믿음에 가서 보자 내가 롭 척하자. 입력합니다. 그건 내가 의도 한 프로그램이 아니다. 그래서 우리는 우리의 첫 번째 블로그가. >> 그러나를 통해 추론하려고하자 왜이 경우입니다. 우선, 첫 번째 문제를 해결 할 수 있습니다. 내가 말하는 여기에 라인을 추가 할 수 printf를, 당신의 이름은 무엇입니까? 그냥 가까운 견적을하자, 괄호를 닫습니다. >> 지금 나 프로그램을 다시 실행하자. 문제가 발생했습니다. 나는 그것을 확인할 수 없습니다. >> 오른쪽. 나는 그것을 다시 컴파일하지 않았다. 그래서 C와 같은 언어로, 당신 때문에 소스 코드를 변경을 의미하지 않는다 Japanese: 私は実際にもう一度カスタム実行するのであれば、 それだけでそこに座っているだろう。 どうなってるの？ 私のプログラムは、上で立ち往生しているように見える 何行目、あなたが言うでしょうか？ >> だから、実際には7行に引っかかっている。 そして、私たちは前にこれを見ていないけど、 7行目では、これは、再び、そこ ステートメントは、文字列を取得します。 そしてそれは、それは言うことありません。 それは人間のために今待っている 文字列を取る。 これは、私にとっては完全に直感的です。 私は言われていないため、人間の、 何をすべきか。 >> しかし、私が信仰に先に行こうと 私はロブのふりをしましょう​​。 入力します。 それは私が意図したプログラムではありません。 だから我々は最初のブログを持っている。 >> しかしを通して推論してみましょう なぜこのような場合である。 まず、私は、この最初の問題を解決しましょう​​。 私が言うここに行を追加してみましょう printfは、あなたの名前は何ですか？ ただ近い見積もりを行うレッツ、 括弧を閉じます。 >> 今私は、プログラムを再実行してみましょう。 問題。 私はそれを見ていないよ。 >> 右。 私はそれを再コンパイルしませんでした。 だから、Cのような言語で、なぜならあなた ソースコードを変更するには、という意味ではありません Malay (macrolanguage): Jadi, jika saya benar-benar menjalankan adat lagi, ia akan hanya duduk di sana. Apa yang berlaku? Program saya seolah-olah terperangkap di apa talian, anda akan berkata? >> Jadi ia sebenarnya terperangkap di talian 7. Dan kami tidak melihat ini sebelum ini, tetapi on line 7, ada, sekali lagi, ini pernyataan, mendapatkan tali. Dan ia melakukan apa yang ia berkata. Ia menunggu sekarang untuk manusia mengambil tali. Ini adalah benar-benar unintuitive kepada saya, manusia, kerana saya telah tidak diberitahu apa yang perlu dilakukan. >> Tetapi biarlah saya pergi ke hadapan pada iman dan biarlah saya berpura-pura menjadi Rob. Enter. Itu bukan program yang saya dimaksudkan. Jadi kita mempunyai blog pertama kami. >> Tetapi mari kita cuba sebab melalui mengapa ini adalah kes itu. P
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({\bold P}-{\bold t}'-\alpha{\bold t}'').$$ We can determine $\alpha$ by solving the linear system $$\label{eq:collinear} {\bold p} \times R^T({\bold P}-{\bold t}'-\alpha{\bold t}'')=0.$$ $M_0,\dots,M_8\leftarrow$ *[Use our symbolic derivations to construct resultant matrices ]{}\ $C_1,C_2\leftarrow$ *[Build generalized eigen-system ]{}\ $\{(q_{2},q_3,q_4)\}_{\{1...64\}}\leftarrow$ Solve eigen-system \ $\{{\dot{{\bold q_i}}}\}\leftarrow$ *[Normalize and keep real solutions]{}\ $ \{U_i\}\leftarrow$ *[extract orientation matrices]{}\ $\{\tau_i\}\leftarrow$ *[Solve for positions linearly using ]{}\ return $\{U_i\},\{\tau_i\}$***** Note finally that with one triple match we need only 4 more pairs of points to solve for all six degrees of freedom in the exterior parameters. (See also [@josephson2007image] for solutions that combine pairs and triplets.) The triple match ${\bold p},{\bold p}_i,{\bold p}_j$ provides two polynomial equations to our polynomial system  (for the pairs ${\bold p},{\bold p}_i$ and ${\bold p},{\bold p}_j$), allowing with the additional 4 pairs to solve for 5 of the DOFs in the camera matrix. The same triple match can be used further to solve for the missing scale using . Figure \[figure:collinear\_degeneracy\] (right) shows the error in recovering camera position for near collinear camera setups. Indeed, in this case, with just pairwise correspondences the position of the recovered camera is determined only up to the scalar $\alpha$. However, using a single matching triplet this scalar is recovered accurately even for exactly collinear cameras. Our method is summarized in Alg.\[Alg:alg\]. [|l|l||c|c|c|c||c|c|]{} & &\ & **Ours** & **Byrod et al.** & **Larsson et al.** & **Stewenius et al.**& **Ours**& **Zheng et al.**\ & 21.4 & 260.1 & **1.7** & 2.3&20.3&**1.4**\ & mean & **6.3096e-07** & 9.7899e-04 &0.2457& 1.8051 &**0.0041**&4.2196\ &median &**7.6592e-09** &5.9371e-08 &3.3821e-05& 0.1330&**7.1092e-08**&3.2804e-04\ & mean & **4.3453e-10** & 7.1570e-08 &9.7387e-04& 0.0045& **5.3624e-07**& 9.9476e+09\ &median &**3.5269e-12** &4.2803e-11 &1.8555e-08&5.5276e-05 &**6.5168e-11** &1.3399e-07\ \[tab:runtimeTable\] \[tab:landmarks\_33\] **More than 3 correspondences from one camera.** $\ $ The $27 \times 27$ Dixon matrix $M $ constructed in  becomes singular when four of the six matching pairs come from a single image $I_i$ ($1 \le i \le n-1$) (and the other two from either one or two images), in which case its rank for a general assignment of $q_2$ is 23. Following Kapur et al.’s main theorem [@kapur1994algebraic], we use the sub-matrix $\overline{M}=M_{1:23,1:23}$ consisting of the first $23$ rows and columns of $M$ which is generally full rank. The solutions for $q_2$ can be found by applying the respective generalized eigen-system for $\overline{M}$. To solve for the remaining variables $q_3$ and $q_4$, we note first that, unlike in the previous case, the obtained eigenvector $\overline{{\bold {v}}}$, which satisfies $\overline{M}\overline{{\bold {v}}}=0$, cannot be used directly toward this goal. Instead, we plug in each of the solutions to $q_{2}$ into $M(q_2)$, obtaining a matrix of rank 22, and reorder its columns so that the columns that correspond to the monomials $[1,q_4,q_4^2,q_4^3,q_4^4,q_4^5]^T$ of ${\bold v}$ are placed on the right of $M$. We next apply the LU decomposition to $M$, so that $M(q_2){\bold v}=LU{\bold v}=0$ which implies that $U{\bold v}=0$. All but the 5 right most entries of the $22^{th}$ row of $U$ are zeros. Multiplying this row by ${\bold v }$ (permuted accordingly) results in a 5-degree polynomial in the single variable $q_4$. For each of the 5 obtained solutions for $q_4$ we once more reorder the columns of $M(q_2)$ this time placing the columns corresponding to the monomials $[1,q_4,q_4^2,q_4^3,q_4^4,q_3]^T$ of ${\bold v}$ on the right. We next use the LU decomposition to obtain a linear equation in $q_3$. We finally plug in the 5 solutions for $q_3$ and $q_4$ into our original system of equations and discard all but the solution of minimum residual. (In practice for stability, we keep the solution that minimizes the Sampson error for the 6 corresponding points.) This case was solved in [@zheng2015structure] and demonstrated empirically 40 solutions. We note, however, that [@zheng2015structure]’s formulation (Eqs. (3-5) in their paper) yields a non tight BKK bound, which is 56. In our formulation, we achieve a tight BKK bound, which is 40, by placing the origin at the center of the camera which has 4 correspondences with the new camera. We note finally that, as is mentioned in [@zheng2015structure], when 5 correspondences come from the same camera we can first recover the essential matrix relating this camera to the new camera. This yields 20 solutions, which we can use to recover 5 of the 6 degrees of freedom in the pose of new camera. We then use the remaining matching pair to recover the remaining parameter (scale of translation). Experiments =========== Runtime and accuracy -------------------- We tested our solution in simulations and on real data. To assess its accuracy we used the Herz-Jesus-P8 dataset [@strecha2008benchmarking] to generate 1000 different configurations of six pairs of points (true matches) that include 1-3 matches from up to 6 cameras. We further generated 1000 6-pair configurations that involve 4 matches from one known camera. We compare our results for the former collection with results obtained with [@stewenius2005solutions; @byrod2009fast; @larsson2017efficient] and on the latter with [@zheng2015structure]. (Recall that the solutions in [@stewenius2005solutions; @byrod2009fast; @larsson2017efficient] are degenerate when 4 matches come from one camera, while [@zheng2015structure] only addressed that special case.) The results are presented in Figure \[fig:noise\_free\] and are summarized in Table \[tab:runtimeTable\]. In each case we show the recovery error of camera orientation along with the residual error obtained when each solution (including ours) is plugged into the system of 30 equations of Stewenius et al. [@stewenius2005solutions] in $q_2$, $q_3$ and $q_4$. (We do not show the errors in the location parameters since in all methods those are solved linearly once the orientation parameters are recovered.) Our method achieves highly accurate results outperforming these existing methods. Our implementation utilizes C code to construct our resultant. The code obtains six candidate matches and their respective camera matrices, as described in Sec. \[sec:definition\], and uses our symbolic expressions (Sec. \[sec:symbolic\]) to produce the nine $27 \times 27$ matrices, $M_0,...,M_8$ . We compiled the code as a Matlab Mex library and used MATLAB to solve the generalized eigen-system described in Sec. \[sec:root\]. Our solution runs in 20.3-21.4ms on a PC with i7-6700 3.4GHz CPU, which is compatible with real-time applications. Extracting Dixon matrix takes only 6ms of the 20ms, much faster than the general implementation [@minimair15] which takes about 17 seconds. Solving the generalized eigen-system of the sparse matrices $C_1$ and $C_2$ of size $216 \times 216 ~\eqref{eq:gen_eigen}$ takes 14ms of the 20ms. Our method is not as fast as the less
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's poor record on press freedoms. Is this because western media outlets have suddenly developed a new-found devotion to defending civil liberties in Latin America? Please. To pose the question is to mock it. It's because feigning concern for these oppressive measures is a convenient instrument for demeaning and punishing Ecuador for the supreme crime of defying the US and its western allies. The government of President Rafael Correa granted asylum to western establishmentarians' most despised figure, Julian Assange, and Correa's government then loudly condemned Britain's implied threats to invade its embassy. Ecuador must therefore be publicly flogged for its impertinence, and its press freedom record is a readily available whip. As a fun bonus, denunciations of Correa's media oppression is a cheap and easy way to deride Assange's supposed hypocrisy. (Apparently, activists should only seek asylum from countries with pristine human rights records, whichever countries those might be: a newly concocted standard that was conspicuously missing during the saga of blind Chinese human rights activist Chen Guangcheng at the US embassy; I don't recall any western media outlets accusing Guangcheng of hypocrisy for seeking refuge from a country that indefinitely imprisons people with no charges, attacked Iraq, assassinates its own citizens with no due process on the secret orders of the president, bombs funerals and rescuers in Pakistan, uses extreme force and mass arrests to try to obliterate the peaceful Occupy protest movement, wages an unprecedented war on whistleblowers, prosecutes its Muslim citizens for posting YouTube videos critical of US foreign policy, embraces and arms the world's most oppressive regimes, and imprisoned Muslim journalists for years at Guantánamo and elsewhere with no charges of any kind.) But this behavior illustrates how purported human rights concerns are cynically exploited as a weapon by western governments and, more inexcusably, by their nationalistic, self-righteous media enablers. Concern over a foreign regime's human rights abuses are muted, often nonexistent, when those regimes dutifully adhere to US dictates, but are amplified to deafening levels when nations defy those dictates and, especially, when it's time to wage war against them. This is why attacks on protesters by US-supported regimes in Bahrain and Saudi Arabia are typically described by western media outlets with the innocuous-sounding, both-sides-are-to-blame term "clashes with rebels", while villain-of-the-moment regimes in Iran, Syria or Libya are said to be slaughtering their own citizens. It's why arming Syrian rebels to enable them to defend against regime oppression is conventional wisdom, whereas arming Palestinian rebels to defend against Israeli violence is criminal. The classic case of this dynamic is the outburst of indignation in 2003 over – all together now – Saddam's "gassing of his own people": something he had done 15 years earlier, in 1988, when the US was arming and funding him and had multiple interests in its relationship with Iraq, and thus evinced little care about any of that. It was only when it was time to demonize Saddam in order to justify the attack did western governments and their media outlets suddenly discover their retroactive rage over those crimes. This exploitation of human rights concerns drives even the most seemingly straightforward cases, such as the universal condemnation among All Decent People of Russia's obviously repellent punishment of Pussy Riot, the anti-capitalist, hardcore-leftwing punk rock band. As the Russian journalist Vadim Nikitin demonstrates in a New York Times op-ed Tuesday, western denunciations of Russia's disregard for free speech are shaped far more by opportunism than anything authentic [my emphasis]: "Pussy Riot and its comrades at Voina come as a full package: you can't have the fun, pro-democracy, anti-Putin feminism without the incendiary anarchism, extreme sexual provocations, deliberate obscenity and hard-left politics. Unless you are comfortable with all that (and I strongly suspect 99% of Pussy Riot's fans in the mainstream media are not), then standing behind Pussy Riot only now, when it is obviously blameless and the government clearly guilty, is pure opportunism. And just like in the bad old days, such knee-jerk yet selective support for Russian dissidents – without fully engaging with their ideas – is not only hypocritical but also does a great disservice to their cause. "A former Soviet dissident and current member of the anti-Putin opposition, Eduard Limonov, knows such cynicism too well. Thrown out of the Soviet Union and welcomed in New York as a cold war trophy, Limonov soon learned that it wasn't the dissent part that the United States loved about Soviet dissidents, but their anti-communism. A bristly and provocative anti-Soviet leftist, he got to work doing what he did best – taking on the establishment – and quickly found himself in hot water again, this time with the Americans. Limonov concluded that 'the FBI is just as zealous in putting down American radicals as the KGB is with its own radicals and dissidents.'" Nikitin notes what most western media accounts have ignored about Pussy Riot: its lead singer's "participation, naked and heavily pregnant, in a public orgy at a Moscow museum in 2008", sponsored by a radical art group that "had previously set fire to a police car and drew obscene images on a St Petersburg drawbridge". Those acts, he accurately observes, "would get you arrested just about anywhere, not just in authoritarian Russia". Does anyone think that an American media that stands by complacently while excessive force and mass arrests are unleashed on the far more peaceful Occupy movement, or which says nothing about the systematic prosecution of American Muslims for core free-speech activities, possesses some sort of genuine concern for free speech and free assembly rights in Russia? As Nikitin rhetorically asks: "Twenty years after the end of the cold war, are dissident intellectuals once again in danger of becoming pawns in the west's anti-Russian narrative?" That's how human rights advocacy is typically used by the west's establishment media: as a thinly disguised instrument for advancing nationalistic goals and, more insidiously, for their individual and collective self-affirmation. There is a huge industry of American political and foreign policy commentators who love to prance around together flamboyantly condemning the rights abuses of other people's governments, while spending very little time and energy condemning abuses by their own. One of the most vivid examples of this warped dynamic is the extremely disparate reaction from the American commentariat when journalists are imprisoned by Bad Foreign Governments as opposed to their own. For seven years, the US imprisoned an al-Jazeera cameraman, Sami al-Haj, at Guantánamo with no charges and spent most of that time interrogating him not about al-Qaida, but about al-Jazeera. With very few exceptions, American media figures failed even to mention, let alone condemn, the due process-free imprisonment of this journalist by their own government. The same silence characterized their reaction to the imprisonment of other Muslim journalists over the last decade by the US government. By very stark contrast, when Iran imprisoned the Iranian-American journalist Roxana Saberi on espionage charges before releasing her five months after her arrest, countless American journalists and self-styled human rights advocates in the media were so very proud of their bold denunciation of the distant Iranian regime, turning the Saberi case into a cause celebre. Exactly the same thing happened with the 2009 conviction and imprisonment by North Korea of American journalists Euna Lee and Laura Ling: American journalists so courageously condemned the tyranny of North Korea. Fixating on the rights abuses of distant governments while largely ignoring those committed by one's own does not only demonstrate the glaring insincerity of the purported beliefs. Far worse, it is an abdication of one's primary duty as a journalist and as a citizen: to oppose, first and foremost, the bad acts of one's own government. Noam Chomsky put this best when asked why he spends the bulk of his time on the crimes of his own government (and its client states) rather than on America's enemies: "My own concern is primarily the terror and violence carried out by my own state, for two reasons. For one thing, because it happens to be the larger component of international violence. But also for a much more important reason than that: namely, I can do something about it. So even if the US was responsible for 2% of the violence in the world instead of the majority of it, it would be that 2% I would be primarily responsible for. And that is a simple ethical judgment. That is, the ethical value of one's actions depends on their anticipated and predictable consequences. It is very easy to denounce the atrocities of someone else. That has about as much ethical value as denouncing atrocities that took place in the 18th century." An eagerness to condemn abuses by foreign governments while largely ignoring one's own is not merely cowardly, though it is that. And it's not merely an abdication of the prime journalistic duty, though it is that, too. Worst of all, it's the media behavior that most effectively bolsters state propaganda, as it signals to the citizenry: human rights violations and civil liberties assaults are something those Bad Foreign Governments over there do, but not your own. I would take more seriously all of this very inspirational, newfound worry about Ecuadorian press freedoms and Russian free speech rights on the part of Western media figures if they evinced any similar interest
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Mr. Joseph was in San Antonio, too. An enormous man, he was dressed in a black T-shirt and shorts, and, when Falafel and The Bone walked over, he and Genius were playing a variant of backgammon involving only three checkers, for five hundred dollars a point. He told Falafel, “You never win in tournaments. The Bone wins. He knows how to win. You find a way to lose to the worst players.” “I want to win, too,” Falafel said. “But sometimes I get into a spot.” The Bone interjected, “It’s going to change now that he is losing weight.” “I play better if I am in better shape,” Falafel said. Since Sushi Saito, he had lost about sixty pounds, and Genius had gained twenty. Just about any time I ran into Genius, he was eating a J.J. Gargantuan Unwich sandwich (seven hundred and thirty-nine calories), from Jimmy John’s. Mr. Joseph was unconcerned; he seemed to take pleasure in the bet’s manipulative aspects. In 1996, he told another player, Brian Zembic, that he would give him a hundred thousand dollars if he got breast implants and kept them in for a year. Months later, Zembic got them, size 38C, and, to everyone’s surprise, he liked them. They helped him meet women, and he ended up marrying one of them. A year came and went—and a hundred thousand dollars was wired to a Swiss bank account—but still he kept the implants in. Once, when Falafel came to visit, Zembic unbuttoned his shirt and danced. Falafel smiled and blushed. In his own way, Falafel wanted to be transformed, too. He wanted to be healthier, more mindful, more purposeful. “My life, I just got into a situation,” he said. “Some of the hardships I endured, I did so without realizing that they were hardships. I should have a family. That is a big missing part of my own puzzle.” Once, in an airport, Falafel sat next to a rabbi, and asked him for his thoughts about gambling. The rabbi said that it was not prohibited, but that a life of gambling was unsanctioned by God. Falafel told me, “I see religion for what it really is: just a bluff,” but he couldn’t get the interpretation out of his head. One evening, outside a casino bathroom, I saw him stop a young bearded man in a yarmulke and say, “I have a question for you: Do you know what Jewish law says about gambling?” The man was taken aback. It didn’t matter—Falafel was already answering. “I think it is that you can gamble, but that you can’t earn a living from gambling. Is that it?” At the Menger, Mr. Joseph had rented the Presidential Suite, and on Super Bowl Sunday he filled it with food and with backgammon players. By then, the tournament was over. The mood was relaxed. Falafel had lost in the semifinals, to a longtime player from Texas, and he had been upset. But now, in Mr. Joseph’s suite, the loss was easily forgotten. There was the Super Bowl to distract him—he had bet many rubles on the Baltimore Ravens. And there was his weight. He stood near an elaborate buffet that Mr. Joseph had arranged. “You can eat this,” a player from Germany said, pointing to a tin of celery. Falafel already had a stalk in his mouth. He took a few carrots and a bottle of mineral water and walked over to a couch. A plate of cheesecakes was set down in front of him. “Those pies,” Mr. Joseph said, casually. “Have one of those pies.” “No,” Falafel said, cradling his belly. “I can’t.” “I’ll give you fifty bucks right now to eat one of those pies,” Mr. Joseph said, pulling out a crisp bill. “How many calories?” Falafel said. “Thirty,” Mr. Joseph said. “Bullshit!” The Bone said. Falafel looked at the money and hesitated. “Jeez,” he said. “You’re giving me a fifty?” But he held his ground. It used to be that tournaments were the center of big-money side games, but these days the few players who make their living from backgammon must look in deeper waters for big fish. Before leaving the Menger, one top player told me in hushed tones that he was going to see a billionaire who puts him up in a hotel near his house so that they can play all-night games for a thousand dollars a point. The billionaire is so obsessive that he can play for fifteen hours uninterrupted; the player told me he had to bring a friend to cover for him during bathroom breaks. From Texas, Falafel and The Bone headed for Los Angeles, where they rented a business suite at a Manhattan Beach hotel. Word had been quietly circulating about a group of wealthy amateurs playing for enormous stakes. Not merely fish—a pod of whales. Who would they be? Ted Turner? Carl Icahn? George and Barbara Bush host a private tournament at Kennebunkport. One of the most-read books in the Bush family is “Backgammon for Blood,” a handbook from the nineteen-seventies. (“Unfortunately, that’s one of the worst books,” a mathematician told me. “It was written under a pseudonym, and some people say it was intentionally bad so that people reading it would play worse.”) Falafel thought he could find a way into the action from the West Coast, but he was fanatically secretive about what he knew. The money was too big—too important to his future. “This is a fantasy,” he told me, by which he meant that the games were just an ephemeral opportunity, a blinding spark. Falafel’s hotel was a favorite of Jersey Jim’s, who had also come, with his wife, Patty. Every day, they went across the street to a gym the size of an LAX hangar. Falafel was relying on them to help him lose weight. But he did not want to lift, or run, or exert himself intensively. Instead, he decided to restrict his diet to a thousand calories per day, and to walk. Jersey Jim and Patty worked on him until he agreed, at least, to climb the Manhattan Beach dune: a steep, two-hundred-and-seventy-foot incline near an Army Reserve facility, where athletes like Kobe Bryant come to work out. On the morning that Falafel and The Bone arrived, a lean man with bleached dreadlocks, shirtless and deeply tanned, was doing yoga on a blanket at the base of the dune. Falafel looked a little intimidated. He watched as The Bone began striding up the incline and then slowed down. “Gee,” he said. “The Bone, he’s realizing that it takes a lot of energy.” Patty turned to Falafel. “This is how you lose weight,” she said. “Yeah, for sure,” Falafel said. He gazed at the hill uncertainly. At his last weigh-in, he was two hundred and forty-five pounds. But things were looking up. He had won on the Super Bowl. He was flying back to Israel to attend a wedding, and to spend some time near his childhood home. Then he was off to Copenhagen, for the Nordic Open—informally known as “Denmark vs. the World.” Falafel, who was captaining “the World,” was putting together an international team, and hoped to bring in Genius and Abe the Snake. The whales seemed increasingly within reach. Squinting in the bright Los Angeles sun, Falafel pushed his feet into the hot sand. Slowly, he began to climb. ♦Q: Find the limit using delta epsilon definition. Evaluate $\lim_\limits{x \to 0}\ \dfrac{e^x-1}{e^{2x}-1}$ using $\delta - \varepsilon$ definition. Attempt: I claim that $\lim_\limits{x \to 0}\ \dfrac{e^x-1}{e^{2x}-1} = \dfrac 12$. $\forall \varepsilon >0, \exists\delta>0$ such that $$|\frac{e^x-1}{e^{2x}-1}-\frac12| = |\frac {2e^x-2-e^{2x}+1}{2e^{2x}-2}|=|\frac {2e^x-e^{2x}-1}{2e^{2x}-2}|\le |\cdot|<\varepsilon$$ I don't know how to proceed from here. I appreciate any hint. A: Will be easier to evaluate if you first factorise the denominator followed by the delta-epsilon evaluation Hopefully you can proceed from there. Next-generation sequencing data analysis | software and service AptaIT is a bioinformatics company dedicated to help researchers worldwide to analyze data from next-generation sequencing (NGS) by user-friendly bioinformatic solutions to enhance their biomedical development programs. AptaIT has developed intelligent software solutions
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+ negotiatedSubProtocol + "] not found in offered subprotocols " + offeredSubProtocols); // We can upgrade customize(endPoint); Request request = response.getRequest(); Negotiated negotiated = new Negotiated( request.getURI(), negotiatedSubProtocol, HttpScheme.HTTPS.is(request.getScheme()), // TODO better than this? extensionStack, WebSocketConstants.SPEC_VERSION_STRING); WebSocketCoreSession coreSession = new WebSocketCoreSession(frameHandler, Behavior.CLIENT, negotiated, wsClient.getWebSocketComponents()); customizer.customize(coreSession); HttpClient httpClient = wsClient.getHttpClient(); WebSocketConnection wsConnection = new WebSocketConnection(endPoint, httpClient.getExecutor(), httpClient.getScheduler(), httpClient.getByteBufferPool(), coreSession); wsClient.getEventListeners().forEach(wsConnection::addEventListener); coreSession.setWebSocketConnection(wsConnection); notifyUpgradeListeners((listener) -> listener.onHandshakeResponse(this, response)); // Now swap out the connection try { endPoint.upgrade(wsConnection); // Try to complete the future but if we could't we should abort the CoreSession if (!futureCoreSession.complete(coreSession)) { futureCoreSession.exceptionally(t -> { coreSession.processConnectionError(t, Callback.NOOP); return null; }); } } catch (Throwable t) { futureCoreSession.completeExceptionally(t); } } } In vivo canine model comparison of cardiohemodynamic and electrophysiological effects of a new antipsychotic drug aripiprazole (OPC-14597) to haloperidol. The cardiovascular effects of aripiprazole were assessed in comparison with those of haloperidol using a halothane-anesthetized canine model with monophasic action potential monitoring. Aripiprazole (n = 6) or haloperidol (n = 6) was infused over 10 min at escalating doses of 0.03, 0.3, and 3.0 mg/kg with intervals of 20 min between doses. Clinically relevant plasma concentrations were obtained after 0.03-0.3 mg/kg of aripiprazole as well as haloperidol. After 0.03-0.3 mg/kg of aripiprazole, positive chronotropic, inotropic, and dromotropic effects, shortening of the ventricular effective refractory period (ERP) and repolarization phase, and decrease of total peripheral resistance were observed in a dose-related manner. However, in the presence of a beta-blocking dose of esmolol (0.1 mg/kg/min), these changes were not induced. After 3.0 mg/kg of aripiprazole administration, cardiac effects induced by the lower doses were attenuated or disappeared, while the negative chronotropic, dromotropic, and hypotensive actions and prolongation of ERP and repolarization phase were induced. After 0.03 mg/kg of haloperidol, no significant change was observed, except for the decrease of the peripheral resistance. After 0.3-3.0 mg/kg of haloperidol, negative chronotropic, inotropic, and hypotensive actions, intraventricular conduction delay, and prolongation of ventricular ERP and repolarization phase were observed in a dose-related manner accompanied by further decrease of the peripheral resistance. The inhibitory effects of aripiprazole on cardiovascular parameters in dogs were less potent than those of haloperidol at clinically relevant exposures, moreover, aripiprazole, unlike haloperidol, neither induced early afterdepolarization nor prolonged the ventricular electrical vulnerable period. Therefore, aripiprazole can be considered safer to use than haloperidol.Allan Jones (engineer) Allan Jones MBE, is an engineer who pioneered Combined Heat and Power (CHP), renewable energy and fuel cell systems in the United Kingdom and Australia from 1990 to the present. Allan Jones Energy and climate change Jones attended Sheerwater secondary modern, Woking; Guildford College of Technology and the Central London Polytechnic. During his early career he spent 18 years with Greater London Council and Inner London Education Authority, working on major development and regeneration projects but is known for his energy and climate change work, particularly decentralised energy in Woking, London and Sydney. In 1999, Jones was awarded an MBE in the New Year’s honours list for services to energy and water efficiency. Greater London Council/Inner London Education Authority From 1971 to 1989 Jones worked for the Greater London Council (1971 to 1986) and the Inner London Education Authority (1986 to 1989) on major development and regeneration projects both as an engineer and senior manager, including London housing projects, Andover Town Development, County Hall projects, Burgess Park new lake and park, the first networked Building Energy Management System in the UK and various school and college projects. Jones was a member of the Department of Mechanical and Electrical Engineering Management Board from 1983 to 1986 and a member of the Department of Building and Property Services Management Board from 1986 to 1989. Woking Borough Council From 1989 to 2004 Jones worked for Woking Borough Council, initially as building services manager and then as energy services manager. He was instrumental in establishing the Council’s energy and environmental services company Thameswey Ltd of which he was a director (1999 to 2004) and its public/private joint venture company Thameswey Energy Ltd which developed and implemented decentralised energy projects in both the public and private sectors. During his time at Woking, Jones reduced CO2 emissions by 77.5% from 1990 levels to 2004, improved the energy efficiency of the existing housing stock within its area by 30% from 1996 to 2004 and undertook groundbreaking work on energy and water efficiency, private wire CHP cogeneration and trigeneration decentralised energy systems, environmentally friendly waste recycling/recovery and energy from waste technologies, alternative fuels for transport, renewable energy and fuel cells. Under Jones, Woking installed 81 private wire decentralised energy systems, nearly 10% of the UK’s total installed solar energy photovoltaics and the first fuel cell CHP in the UK. Woking was able to implement private wire networks under the UK’s exempt licensing regime . In 2001, Jones was instrumental in Woking being awarded a Queens Award for Enterprise: Sustainable Development for his work in the development of local sustainable community energy systems, the only local authority ever to receive a Queens Award for Enterprise. London Climate Change Agency In 2004, the then Mayor of London, Ken Livingstone recruited Jones to head up his new climate change agency for London as chief executive officer (2004 to 2008) of the London Climate Change Agency Ltd (LCCA), a municipal company that developed and implemented projects in the sectors that impact on climate change, especially in the energy, water, waste and transport sectors. In addition to being chief executive officer of the LCCA, Jones was also the LCCA’s executive director of the London ESCO Ltd and the LCCA’s director of the Better Buildings Partnership Ltd, a company limited by guarantee between the LCCA and major landlords in London to reduce CO2 emissions from major commercial and public buildings. During his time in London Jones set up and ran the LCCA, developed the energy and climate change elements of the London Plan, Mayor’s Climate Change Action Plan and the new Mayoral Climate Change Statutory Duty as well as developing and implementing decentralised energy and renewable energy projects in London. One of the key projects that Jones implemented was the procurement and establishment of the London ESCO, a public/private joint venture Energy Services Company between the LCCA Ltd and EDF Energy plc, which designs, finances, builds and operates decentralised energy systems for both new and existing development. Jones is credited with the removal of the regulatory barriers to decentralised energy in the UK with the high level advocacy and lobbying that led to the creation of a separate electricity supply licence for decentralised energy or distributed generation to supply electricity over the local distribution network, otherwise known as the ‘virtual private wire’ over public wires principle. The UK Energy Regulator – the Office of Electricity and Gas Markets enacted the new licence in March 2009 . On 22 May 2008, Jones appeared in an interview, shot in London and Woking, as part of the Australian ABC’s Catalyst programme (2008 Episode 14). The story featured Jones past work in Woking and the LCCA’s plans for implementing decentralised energy systems in London. This led to Jones being invited to visit Sydney as a guest of the City of Sydney and the New South Wales state government. A public talk ‘City Talk: Green Transformers, revolutionising energy generation for a Sustainable Sydney’ was held on Tuesday 22 July 2008 at the Theatre Royal, MLC Centre, King St, Sydney. The visit also included media coverage, like that on ABC Radio National’s Saturday Extra programme. Sustainable Environment Foundation From 2007 to 2009 Jones was a director-trustee of the Sustainable Environment Foundation, a foundation that promotes for the benefit and advances the education of the public the conservation, protection and improvement of the physical and natural environment. Allan Jones Energy and climate change From 2008 to 2009 Jones worked as an energy and climate change consultant both in the UK and overseas, including working for the City of
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all of the items they require to submit for and obtain a building permit. Additionally, stock plans do not have a professional stamp attached. If your building department requires one, they will only accept a stamp from a professional licensed in the state where you plan to build. In this case, you will need to take your house plans to a local engineer or architect for review and stamping. In addition, plans which are used to construct homes in Nevada are required to be drawn by a licensed Nevada architect.// Copyright 2013 Smartling, Inc. // Licensed under the Apache License, Version 2.0 (the "License"); // you may not use this work except in compliance with the License. // You may obtain a copy of the License at // // http://www.apache.org/licenses/LICENSE-2.0 // // Unless required by applicable law or agreed to in writing, software // distributed under the License is distributed on an "AS IS" BASIS, // WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. // See the License for the specific language governing permissions and // limitations under the License. // // AppDelegate.h // PluralsDemo // // Created by Pavel Ivashkov on 2013-02-25. // @interface AppDelegate : UIResponder <UIApplicationDelegate> @property (strong, nonatomic) UIWindow *window; @end Incidence of complications and problems related to orthognathic surgery. This retrospective report evaluates the incidence of intra- and postoperative complications of orthognathic surgery and their relevance. The clinical records and radiographs of 301 patients who underwent surgery at Chosun University Dental Hospital, Korea, over an 8-year period between 1998 and 2005 were examined. The most common complication was a neurosensory deficit in the region innervated by the inferior alveolar nerve. The most serious complication was severe intraoperative bleeding. No complication was fatal. Despite the great variety of severe complications reported, their frequency seems to be extremely low. Orthognathic surgery appears to be a safe procedure.Q: What scenario requires use of call_user_func() in php I dont understand the function, call_user_func() in the sense that i get how it works but I'm not sure why its required or in what context to use it in php. As far as I'm concerned why not just call the function instead of calling a function with a function? Thnx! A: I've had a couple situations where this was very necessary. For example, when I was creating a project that allowed a user to construct parts of a programming language, the system would wrap the "tag" definition in a function before running it for security reasons. However, in doing this, I can't simply call those functions, because I don't know when I need to call them, or even what the names would be. Enter call_user_func()... So, I'm sure you're confused right now. Let me explain. What my system did, was take some XML, and convert it into PHP/HTML/JS with PHP. This allowed for rapid creation of GUIs (which was the goal). Take this XML for example: <window id="login-win" title="Access Restricted" width="310" height="186" layout="accordion" layoutConfig="animate:true"> <panel id="login-panel" title="User Login"> <form id="login-form" title="Credentials"> <textbox id="login-uname" label="Username"/> <password id="login-pass" label="Password"/> <submit text="Login"/> </form> </panel> <panel id="login-register" title="Register"> Nothing, you can't register! </panel> </window> Each XML tag would be read, then fed into it's corresponding PHP function. That function would determine what to do for that 1 tag. In order to pull this off, I had files each named after the tag it handled. So, for example, the tag's file was "submit.php". This file's contents would get wrapped in a generated function, something like: function tag_submit($variables, $parent, $children){ // deal with the data, then echo what is needed } This function's name would be stored in an array, with it's associated tag name, with the rest of the generated functions. This makes it so the function is generated once, and only created when needed, saving memory, since I would do a if(func_exists()) call to determine if I needed it or not. However, since this is all dynamic, and the user may want to add in a new tag, for say, a < date > tag, I needed to use call_user_func() to get things to work. I can't hard-code a function call if I don't know what the name is. Hope that all made sense. Basically, yes, it is a rarely used function, but it is still very very useful. Getting Started with Elixir - Pattern Matching We discussed the = operator in the previous section where we used it to assign a value to a variable. But in Elixir it's actually called the match operator because it has a powerful feature built into it that that enables us to perform what is known as "Pattern Matching". Pattern Matching is used almost as often as functions in Elixir which makes it an important core feature to utilize in your programs. Pattern Matching is the act of checking a given sequence of tokens for the presence of the constituents of some pattern. A slightly cryptic definition, but we can break this down using some examples. Ensure you have Elixir and IEx installed to follow along and test the examples. Elixir Series Connect I hope you're finding this series helpful. If you find any issues or have any feedback feel free to hit me up on twitter: @tmartin8080 || @phxroad or subscribe to the mailing list to receive occasional updates.“Kim Jong Un of North Korea proclaims ‘unwavering faith in President Trump,’” the U.S. president tweeted. “Thank you to Chairman Kim. We will get it done together!” But there also was a reminder of the current impasse in negotiations. North Korean media repeated the country’s demand that the United States make the next move by formally declaring an end to the Korean War, which concluded in 1953 with an armistice but not a peace treaty. The North insists Trump promised such a declaration when he met Kim in Singapore in June. But it is a move that Washington is reluctant to make, fearing that it could ultimately throw into question the continued presence of U.S. troops in South Korea. AD AD The South Korean envoys delivered a letter from President Moon Jae-in, as well as a message from Trump, who spoke to Moon by telephone earlier in the week. The two sides agreed that a planned summit between the leaders of both Koreas would take place in Pyongyang on Sept. 18-20, and they pledged to open a joint liaison office in the North before then. “I have big expectations for the upcoming inter-Korean summit,” Moon told officials on Thursday, according to the presidential Blue House. “I also have expectations for complete denuclearization of the Korean Peninsula, and for talks between North Korea and the United States to be accelerated as well.” AD In Wednesday’s meeting, North Korea’s Kim expressed frustration with skepticism in some parts of the international community about his commitment to denuclearize, according to Chung Eui-yong, South Korea’s director of national security and the leader of the team of envoys. AD The North Korean leader also pointed to the dismantling of the Punggye-ri nuclear test site and Dongchang-ri missile launch facility as evidence of his commitment to end nuclear testing permanently, Chung said. And he asked for a message to be delivered to Trump. That message will very probably contain an appeal for the United States to formally declare an end to the war, something North Korea says is vital to building trust and ending decades of hostility. AD Kim said such a declaration would not imply a withdrawal of U.S. troops or a weakening of the U.S.-South Korean military alliance, Chung added. “Chairman Kim said that although the dialogue between the U.S. and North Korea is experiencing some difficulties, his trust in President Trump continues, especially at times like this,” Chung told a news conference the day after his return. AD He added that Kim pledged to “to end 70 years of hostile relations with the United States, improve the bilateral relationship and fulfill denuclearization before the end of President Trump’s first term.” An end-of-war declaration is seen as only a first step toward a full peace treaty, which in theory would involve the denuclearization of the Korean Peninsula and normalization of diplomatic relations between Pyongyang and Washington, diplomats say. AD On Thursday, North Korea’s Rodong Sinmun newspaper said the Trump administration must discard its “stubborn” stance that the North must denuclearize first before the United States agrees to a peace treaty. It said North Korea has shown “goodwill and generosity” through actions such
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.48\columnwidth"} ![Eccentricity evolution obtained by assuming different levels of third-body perturbation of $e,i,\Omega,\omega$, compared against the TLE evolution for some specific examples. More details in the text. Top: orbits \#1 and \#2: middle: \#7 and \#13; bottom: \#15 and \#19. All the other orbits are shown in Appendix B. []{data-label="fig:prop_semplici_examples"}](te_tepropsempl_final_new_19.png "fig:"){width="0.48\columnwidth"} First, we notice that almost no difference is appreciable between the results of [*model 3*]{} (black) and [*model 4*]{} (yellow). Moreover, the role of the lunisolar perturbation in $\Omega$ and $\omega$ plays a central role in catching the real evolution of the orbit. This is appreciable comparing the cyan, green and red lines. A further improvement is obtained by adopting [*model 3*]{}, that can match perfectly the real evolution of the eccentricity in many cases (e.g., Molniya 1-32, 3-13 and 3-20 – orbits \#7, 15, 19). In general, it seems sufficient to consider $l=2$, $m=0,1$, $s=0,1$ for the Moon and $l=2$, $m=0,1$ for the Sun, that is, not a full quadrupolar approximation. In Fig. \[fig:prop\_semplici\_examples\_tBom\_tpom\] the behavior of $\Omega$ and $\omega$, assuming different assumptions for the associated dynamical model, is shown for two examples. ![Longitude of the ascending node (left) and argument of pericenter evolution (right) evolution obtained by assuming different levels of third-body perturbation of $e,i,\Omega,\omega$, compared against the TLE evolution for some specific examples. More details in the text. Top: \#2; middle: \#7; bottom: \#15. []{data-label="fig:prop_semplici_examples_tBom_tpom"}](tBom_propsempl_final_2.png "fig:"){width="0.48\columnwidth"} ![Longitude of the ascending node (left) and argument of pericenter evolution (right) evolution obtained by assuming different levels of third-body perturbation of $e,i,\Omega,\omega$, compared against the TLE evolution for some specific examples. More details in the text. Top: \#2; middle: \#7; bottom: \#15. []{data-label="fig:prop_semplici_examples_tBom_tpom"}](tpom_propsempl_final_2.png "fig:"){width="0.48\columnwidth"}\ ![Longitude of the ascending node (left) and argument of pericenter evolution (right) evolution obtained by assuming different levels of third-body perturbation of $e,i,\Omega,\omega$, compared against the TLE evolution for some specific examples. More details in the text. Top: \#2; middle: \#7; bottom: \#15. []{data-label="fig:prop_semplici_examples_tBom_tpom"}](tBom_propsempl_final_7.png "fig:"){width="0.48\columnwidth"} ![Longitude of the ascending node (left) and argument of pericenter evolution (right) evolution obtained by assuming different levels of third-body perturbation of $e,i,\Omega,\omega$, compared against the TLE evolution for some specific examples. More details in the text. Top: \#2; middle: \#7; bottom: \#15. []{data-label="fig:prop_semplici_examples_tBom_tpom"}](tpom_propsempl_final_7.png "fig:"){width="0.48\columnwidth"}\ ![Longitude of the ascending node (left) and argument of pericenter evolution (right) evolution obtained by assuming different levels of third-body perturbation of $e,i,\Omega,\omega$, compared against the TLE evolution for some specific examples. More details in the text. Top: \#2; middle: \#7; bottom: \#15. []{data-label="fig:prop_semplici_examples_tBom_tpom"}](tBom_propsempl_final_15.png "fig:"){width="0.48\columnwidth"} ![Longitude of the ascending node (left) and argument of pericenter evolution (right) evolution obtained by assuming different levels of third-body perturbation of $e,i,\Omega,\omega$, compared against the TLE evolution for some specific examples. More details in the text. Top: \#2; middle: \#7; bottom: \#15. []{data-label="fig:prop_semplici_examples_tBom_tpom"}](tpom_propsempl_final_15.png "fig:"){width="0.48\columnwidth"} We have tested also the following extensions to [*model 4*]{}: - $l=3$ also for the Sun for the propagation of $e,i$; - $l=4$ both for Sun and Moon for the propagation of $e,i$; - $l=3$ for the Moon also for the propagation of $\Omega, \omega$. In these cases, we have not found any improvements in the qualitative behavior of the orbit (excluding the drag regime). ![On the left, a close-up view of the semi-major axis evolution given by TLE for Molniya 3-24 (orbit \#23). On the right, in black the eccentricity evolution starting before the change in the amplitude of oscillation of $a$, that can be seen at about MJD $48100$; in magenta the new orbital propagation, starting from the initial condition given in Tab. \[tab:new\_ic\].[]{data-label="fig:case23"}](ta_jump_new_23.png "fig:"){width="0.48\columnwidth"} ![On the left, a close-up view of the semi-major axis evolution given by TLE for Molniya 3-24 (orbit \#23). On the right, in black the eccentricity evolution starting before the change in the amplitude of oscillation of $a$, that can be seen at about MJD $48100$; in magenta the new orbital propagation, starting from the initial condition given in Tab. \[tab:new\_ic\].[]{data-label="fig:case23"}](te_tepropsempl_prova_new_23.png "fig:"){width="0.445\columnwidth"} ![On the left, a close-up view of the semi-major axis evolution given by TLE for Molniya 2-10 (orbit \#2). In black, the initial condition in semi-major axis used for the propagation shown in Fig. \[fig:prop\_semplici\_examples\]; in magenta the new initial condition whose propagation matches the behavior given by the TLE. On the right, the eccentricity evolution for the two propagations and the one given by TLE.[]{data-label="fig:case2"}](ta_jump_new_2.png "fig:"){width="0.48\columnwidth"} ![On the left, a close-up view of the semi-major axis evolution given by TLE for Molniya 2-10 (orbit \#2). In black, the initial condition in semi-major axis used for the propagation shown in Fig. \[fig:prop\_semplici\_examples\]; in magenta the new initial condition whose propagation matches the behavior given by the TLE. On the right, the eccentricity evolution for the two propagations and the one given by TLE.[]{data-label="fig:case2"}](te_tepropsempl_prova_new_2.png "fig:"){width="0.445\columnwidth"} [rrrrrrrrr]{} \# & Molniya & NORAD & $t_0$ & $a$ & $e$ & $i$ & $\Omega\quad$ & $\omega$\ & & ID$\quad$ & \[MJD\] & \[km\] & & \[deg\] & \[deg\]$\quad$ & \[deg\]\ 2 & 2-10 & 7376 & 47628.06 & 26573.53 & 0.742 & 62.06 & 277.27 & 260.24\ 23 &3-24 & 15738& 48200.85 & 26576.61& 0.712 & 63.49 & 65.71 & 278.18\ The cases that cannot be explained with [*model 3*]{} are Molniya 2-10, 3-10 and 3-24 (i.e., orbits \#2, 13, 23). For Molniya 3-10, in particular, this is due to the significant reduction in semi-major axis that takes place before MJD $50000$ (see Fig. \[fig:3serie\]). Other mismatching behaviors, but less evident, can be seen in correspondence of a significant, but less dramatic decrease in $a$, for example for Molniya 1-49 (orbit \#16 in Fig. \[fig:3serie\]). For Molniya 3-24 (orbit \#23), from the corresponding eccentricity evolution shown in Fig. \[fig:4serie\], we can notice that the amplitude of oscillation of $a$ changes at about MJD $48100$. A new numerical propagation starting after
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And children will always find ways to break a mother’s heart. Coincidence? Perhaps not. Women have more pain in childbirth than any other creature. God 1, Woman 0. And the Puritans took the Curse very seriously. In 16th and 17th century Europe, midwives were tried and burned at the stake as witches for administering any form of pain relief. There was an outcry from the Church when chloroform was discovered and used in childbirth by Sir James Simpson in the early 19th century. It was seen as an unholy attempt to rebel against God’s curse on Eve. Even Queen Victoria was heavily criticized for having used anaesthesia with the birth of her 8th child. But Eve’s second curse is the real cracker:“… yet your desire shall be for your husband, and he shall rule over you.” I confess I am thoroughly enjoying the very suggestion of a man’s divine right to rule over his wife. After all, Adam did name her Woman because she was created of man (Genesis 2:18-23). This is no slip of the quill; Genesis earlier recognised the headship of man before the Fall (Genesis 2:18 and 2:22). This means that God’s later ruling ‘he shall rule over you’ cannot be a punishment in itself and is accordingly, simply the way things are. So to obey God’s edict the wife must submit to her husband, I surmise with glee. What’s worse is ‘desire’ is interpreted as Woman’s need to ‘control’[4] her husband. This is a curse because her need can never be fulfilled, as man’s headship is an edict of God that cannot be usurped. God 2, Woman 0. St. Paul himself did not accept Woman’s control over man. He said (I Timothy 2:11-15), “And I do not permit a woman to teach or to have authority over a man, but to be in silence. For Adam was formed first, then Eve. And Adam was not deceived, but the woman being deceived, fell into transgression. Nevertheless she will be saved in childbearing if they continue in faith, love, and holiness, with self-control.” The Twentieth Century New Testament provides a truly brave translation of this clause, “But women will find their salvation in motherhood”. Try telling Liz Taylor that childbearing and submission to her husband (singular) are her salvation. But the puritans condemn Eve for the consequence of her deeds. This is what they say. She disobeyed God and seduced Adam to follow suit. Adam was then punished because he ‘listened’ to her over God. Consequently, God cursed the Earth. Their sin, which had not been forgiven by God, was bequeathed to all their descendants. To absolve Man of this ‘original sin’, God sacrificed Jesus, his son in Christian dogma. (Umm, why God did not simply forgive us all without crucifying Jesus is not for me to ask.) So Eve caused Adam’s sin, the original sin of all Man, the death of Christ and the end of the world. It’s like blaming the flap of a butterfly’s wings in Brazil for a tornado in Texas.[5] All butterflies should have their wings removed and like Woman, find salvation in raising larvae. The reality, however, is that women are attributed with the qualities of the Biblical Eve, unworthy, manipulative and filled with deception and guile.[6] As an example, see Ecclesiastes 7:26-28: “I find more bitter than death the woman who is a snare, whose heart is a trap and whose hands are chains. The man who pleases God will escape her, but the sinner she will ensnare ... while I was still searching but not finding, I found one upright man among a thousand but not one upright woman among them all”. Orthodox Jewish men in their morning prayers recite the following benediction to Yahweh, “Blessed be [God] King of the universe that Thou has not made me a woman.”[7] And another: “Praised be [God] that he has not created me a gentile. Praised be [God] that he has not created me a woman. Praised be [God] that he has not created me an ignoramus.” Equating Woman with gentiles is a little harsh. But there are limits to this sexist Biblical nonsense. The joke ends with the original Protestant, Martin Luther, if he actually[8] said: “If they become tired or even die, that does not matter. Let them die in childbirth, that's why they are there”. Ironically, there is no Quranic condemnation of the Muslim Eve and her purdah practicing daughters. In the Islamic version of our story (2:31-36), (7:19-25), (20:115-123), Allah never blamed Eve for Adam’s sin and neither Eve nor her daughters were cursed with the misery depicted in the Bible. The Hadiths may say otherwise, but not the Quran. The real disappointment is Adam, or at least the Genesis/Ben Sira version. He is a wuss. He was given Lilith but went whinging to God when she left him for demons. He was then given Eve. But he could not even say ‘No’ to her for God’s sake. He hid behind aprons and even blamed Eve for disobeying God. Clearly, he was no match for Woman. He was conned by Eve and bollocked by Lillith; but in her defence, Lilith cannot be blamed for refusing to spend eternity with a poof like Adam. God, of course, is far more formidable. So after more than 3,000 years, Christian puritans must be appalled at Woman’s late charge in the 21st century in meeting her Curse. The epidural has all but rendered pain in childbirth obsolete. God 2, Woman 1. And in the modern home, her control over her domesticated husband (inexplicably called a pussy) is all but complete. God 2, Woman 2. And even without a Hilary win, we have women prime ministers and presidents who, despite St. Paul, rule over nations of men. God 2, Woman 3. Oh ... and what was that Curse again? [2] There has been some argument about the translation: the word translated as ‘pain’ is the Hebrew etzev. The Christian apologist will argue that to ensure consistency, etzev means ‘toil’ as is used in relation to Adam in Genesis 3:17 and not ‘pain’. This remains a minority view. The Greek translation of the Hebrew Bible to translate etzev in Genesis 3:16 made by 70 scholars in 300 B.C. uses the Greek word lupê, meaning also pain of body. [3] The curse could not have been of actually having children as the earlier command was “be fruitful, and multiply” (Genesis 1:27). [4] In the same sense as in Genesis 4:7: “[Sin's] desire is for you, but you should rule over it.” [6] Thefollowingquotes are takenfromthecontroversialarticleWomen in Islam Versus Women in the Judaeo-Christian Tradition,The Myth and The Reality by Sherif Abdel Azim, Ph.D. But see the rebuttal in A Response to Sherif Abdel Azeem's Eve's Fault and Eve's Legacy by Anthony Wales. No need to be so smug. Wipe off that smirk. And might as well stop gloating bro. Just ask any Muslim woman how they have been treated from forever until today (still living in the 1st century perhaps?)...as compared to the modern Christian woman, or a Buddhist woman or any woman with or without a religion. How is it like, for a Muslim woman, to share her 1 husband with the other legal 3 wives for a start..? This is what happens when a legally trained mind goes through the fine print in the Scriptures and spots more than a couple of loopholes. Seems we've both been pondering parallel issues, Art! Thanks for a very pleasant chuckle :-) Anyone who takes the Genesis in its literal form will never a picnic be. It was not knowledge per se that God was trying to spare us, but the knowledge of good and evil. Looking upon the very depravity of evil manifest in man, you would still see this knowledge and its weilding thereof as providentially beneficial? But please carry on. It's good for a few cynical smirks, and therein endures its value. As said Anonymous, try it on the other foot and watch the cinders in the aftermath of religious demonstrations. About Me Art Harun believes that he is a failed government experiment, abandoned and left alone to roam the streets after all remedial efforts yielded no positive result. He calls himself a non-governmental organism, practices law for a living and tries very hard to play guitar, sing, race cars and write some stuffs to stay alive.namespace Humanizer { /// <summary> /// Can truncate a string. /// </summary> public interface ITruncator { /// <summary> /// Truncate a string /// </summary> /// <param name="value">The string to truncate</param>
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, you could take a look at the source code of DataTypeAttributeAdapter: MergeAttribute(context.Attributes, "data-val", "true"); MergeAttribute(context.Attributes, RuleName, GetErrorMessage(context)); And also: ValidationAttributeAdapterProvider: ... else if (type == typeof(CreditCardAttribute)) { adapter = new DataTypeAttributeAdapter((DataTypeAttribute)attribute, "data-val-creditcard", stringLocalizer); } ... else if (type == typeof(EmailAddressAttribute)) { adapter = new DataTypeAttributeAdapter((DataTypeAttribute)attribute, "data-val-email", stringLocalizer); } else if (type == typeof(PhoneAttribute)) { adapter = new DataTypeAttributeAdapter((DataTypeAttribute)attribute, "data-val-phone", stringLocalizer); } else if (type == typeof(UrlAttribute)) { adapter = new DataTypeAttributeAdapter((DataTypeAttribute)attribute, "data-val-url", stringLocalizer); } ... That means when dealing with Email, Phone, etc, ASP.NET Core will also reuses the DataTypeAttribute and generate different validation meta info for you (But DateTypeAttribute doesn't validate those fields). [Update]: Maybe using DataType=Currency as commented by @Hooman Bahreini is a better example. But here the renderedtype of input will not be number but a plain text. A text is not a HTML5 feature. Also, I'll use DisplayFor() as an example now. Consider the following fields: [Column(TypeName = "decimal(10, 4)")] public decimal PlainPriceField { get; set; } [DataType(DataType.Currency)] [Column(TypeName = "decimal(10, 4)")] public decimal PriceWithDateType { get; set; } [DataType(DataType.Currency)] [Column(TypeName = "decimal(10, 4)")] [DisplayFormat(DataFormatString = "₿ {0:F3}BTC", ApplyFormatInEditMode = false)] public decimal PriceWithDateTypeAndDisplayFormat { get; set; } By default, the database will store decimal with a scale of 2. To make this question clear, I add a [Column] annotation to declare them as decimal(10,4). And then, I set all the price fields =1.2345. Note all these fields has a value of 1.2345 in memory. However, when rendered to end user, the result of @Html.DisplayFor(item=>item.XyzPriceField)will be : PlainPriceField: 1.23 PriceWithDataType: $1.23 (instead of 1.2345 or €1.2345 or anything else) PriceWithDataTypeAndDisplayFormat: ₿ 1.235BTC The PriceWithDataType is rendered with a prefix $, which is a dollar sign determined by the current locale. Be aware in this case there's no HTML5 support for currency at all(it will be rendered as a text). Also we didn't set a string template for this currency field. By checking the [DataType(DataType.Currency)] annotation, the ASP.NET Core framework knows this is a currency number and should be displayed in some particular format. Although there's no HTML5 support for currency, the end user will get a $1.23. The way how ASP.NET Core choose the built-in format for certain DataType is already covered above. Lastly, if you provide a [DisplayFormat] at the same time, ASP.NET Core will prefer that format defined in DataFormatString. All Around India: Chhattisgarh The next place our Sunday School teacher took us to is Chhattisgarh! Chhattisgarh is hard to spell! It’s also one of the newer states in India. Up until the year 2000, it was part of Madhya Pradesh. Chhattisgarh has lots of beautiful forests and trees. The timber from the trees, especially the teak and the sal, provide income for some of the people. There is also a lot of bamboo that grows in Chhattisgarh, and people use it to make all kinds of things like furniture, things to cook with, beautiful baskets, and tools for farming. There are national parks in Chhattisgarh to protect some of the exotic animals that live there—including tigers. And, there are lots of valuable minerals that people mine there that can provide income, such as copper, coal, iron, and even diamonds. Chhattisgarh is also home to many Ganda (or Gond) people, who are part of the Dalits. Do you remember the last time our teacher told us about the Dalits? She told us that many of the people of India look down on the Dalits. They treat their animals better than they treat Dalits. It is also dangerous for a Ganda to accept Jesus as their Savior. Do you remember the story she told us about what life is like for Ganda people who choose to believe in Jesus? I’m going to pray that all of the people of India would understand that people, including the Dalits, are more valuable than any animal, mineral, or resource. Will you pray with me? “Dear God, please help the people of Chhattisgarh and all over India to understand that every single person is so valuable to You that You would rather die than live without them. Help them hear how Jesus came to Earth to pay for the mistakes we make and how He was stronger than death and came back to life. Help each person to know how much You love them and trust in You for the life that never ends. Thank You. In Jesus’ Name. Amen.”Design of a switching controller for nonlinear systems with unknown parameters based on a fuzzy logic approach. This paper deals with nonlinear plants subject to unknown parameters. A fuzzy model is first used to represent the plant. An equivalent switching plant model is then derived, which supports the design of a switching controller. It will be shown that the closed-loop system formed by the plant and the switching controller is a linear system. Hence, the system performance of the closed-loop system can be designed. An application example on controlling a two-inverted pendulum system on a cart will be given to illustrate the design procedure of the proposed switching controller.You Whether you feel isolated, misunderstood and left alone with experiences that may have left you heartbroken, confused and almost speechless – your decision to reach out for help and look for someone to connect with could be spark that can ignite the change process you are looking for. “The world is not mine alone and furthermore my perception of the world is shaped largely by the presence of others and others have their own projects they are engaged in.” SartreA 5,188 square foot duplex apartment in Hong Kong has been sold for HK$497.9 million, or Dh235.8 million, claimed to be the most expensive unit to be sold in Asia, according to media reports. The ‘South China Morning Post’ newspaper named the buyer Daniel Aaxman, a director of Lead Connection, quoting the Hong Kong Land Registry records. He paid K$95,971 per square foot for the apartment in Opus Hong Kong. The unit includes two car parking spaces. The sale broke the previous record for price per square foot, set in April, when a company director with a Singaporean passport, Wang Shuang, paid HK$93,000 per square foot for a HK$433.8 million home on the 45th floor of 39 Conduit Road, the newspaper said. Opus, a 12-storey tower completed in 2012, has been dubbed the most expensive apartment tower in Hong Kong. It has been designed by Canadian-American architect Frank Gehry. Every unit in the twisted-shape building has floor-to-ceiling windows and offers 360-degree views of Victoria Harbour and Mount Cameron. In June 2015, UK-based Knight Frank’s global house prices index revealed prices in Hong Kong had risen at the fastest pace than any country over the 12 months to March 2015. Prices had increased by 19 per cent over the period due to shortage of homes despite the government introducing cooling measures in 2013 such as a tax on homes sold within five years of their purchase and buyers having to make a 40 per cent down payment for second homes. Emirates 24|7 reported that an apartment sold for Dh12.90 million on the Palm Jumeirah, topping the list of 10 biggest apartment deals in Dubai in the first quarter 2015.Our Program Inside the MFA in Creative Writing & Poetics The Master of Fine Arts (MFA) in Creative Writing and Poetics at the University of Washington Bothell (UW Bothell) is dedicated to helping each student develop their creative work through a course of study that encourages exploration and discovery. Through an emphasis on poetics, or why we write how we write, we invite students to participate in a forum and laboratory that focuses on the pursuit of creative writing in a rapidly changing society. The intensive, first year curriculum is based on areas of inquiry, rather than genres, creating an alternative to most
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. Platinum Gaming Limited is licensed by: (i)The UK Gambling Commission (“UKGC”). This public regulatory body is responsible for the governance of all forms of gaming based in the United Kingdom. Find out more about the UKGC on www.gamblingcommission.gov.uk.( Find out more information about the Licence ); (ii) The Government of Gibraltar (under Licence numbers RGL 091 & RGL 092) and regulated by the Gibraltar Gambling Commissioner under the Gambling Act 2005. The official number and date of issues of the licenses: Combined Continuation Remote Operating Licence number 000-045322-R-324275-001 issued on 1 July 2016 and valid from 12 July 2016.Woodruff County Courthouse The Woodruff County Courthouse is a historic courthouse at 500 North 3rd Street in Augusta, the county seat of Woodruff County, Arkansas. It is a monumental brick Romanesque Revival building, designed by the noted Arkansas architect Charles L. Thompson and built in 1900. It is roughly rectangular with a hip roof, but has projecting sections as well as a five-stage tower, capped by a pyramidal roof. Its main entrance is to the left of the tower, recessed in a round-arch opening. The building was listed on the National Register of Historic Places in 1982. Gallery See also National Register of Historic Places listings in Woodruff County, Arkansas References Category:County courthouses in Arkansas Category:Courthouses on the National Register of Historic Places in Arkansas Category:Romanesque Revival architecture in Arkansas Category:Government buildings completed in 1901 Category:Buildings and structures in Woodruff County, Arkansas Category:National Register of Historic Places in Woodruff County, Arkansas Silicon Valley is terrified of California’s privacy law - ssklash https://techcrunch.com/2019/09/19/silicon-valley-terrified-california-privacy-law/ ====== nabnob I see a lot of comments deriding this law, can someone explain to me why these are bad things? Quoting from this article - [https://techcrunch.com/2018/06/28/landmark-california- privac...](https://techcrunch.com/2018/06/28/landmark-california-privacy-bill- heads-to-governors-desk/) \- Businesses must disclose what information they collect, what business purpose they do so for and any third parties they share that data with. \- Businesses would be required to comply with official consumer requests to delete that data. \- Consumers can opt out of their data being sold, and businesses can’t retaliate by changing the price or level of service. \- Businesses can, however, offer “financial incentives” for being allowed to collect data. \- California authorities are empowered to fine companies for violations. I totally understand that this will impact a lot of tech companies' profits...but that's to be expected if you're making money selling people's data to third parties without their permission. ~~~ darawk > \- Consumers can opt out of their data being sold, and businesses can’t > retaliate by changing the price or level of service. This is something I object to. It's just fundamentally stupid and doesn't make sense. The entire premise of free exchange is that I give you my services in exchange for something of value of yours. Making it illegal to withhold services if you don't give up your data is crazy. The only reason those services are being provided at all is to get that data. That's effectively a requirement that people provide services _for free_. EDIT: I'll also add that it strongly favors incumbent tech companies, by explicitly carving out "selling to third parties" as a disfavored tactic. Google can monetize your data internally. Your average startup may not be able to. Specifically carving out "selling to third parties" favors large, incumbent players over small startups. But then, regulation always does. ~~~ joshklein Charging different customers a different price for the same product is illegal under US law, and California laws don’t change that. EDIT: Several comments below point out the innumerable businesses operating in such a way as to make mine an impossible claim. Enumerating the established methods to avoid meeting the legal parameters of price discrimination is not the same as price discrimination being legal. My bar for following just laws is higher than the minimum required to avoid being prosecuted. I’m sure experts can help work around any future privacy laws too, so why even worry? Surveillance already creates a different product one can charge more for, though your lawyer might advise you call it “personalization” in memos. ~~~ reaperducer _Charging different customers a different price for the same product is illegal under US law_ Demonstrably untrue. It is illegal to charge a different price based on a protected class like race or gender. But travel sites, for example, are notorious for charging different people different prices based on their GeoIP, whether they're on mobile or desktop, or Windows vs Macintosh. ~~~ lightedman "Demonstrably untrue." Robinson-Patman Act says "Please read me, and understand me and the Clayton Anti-Trust Act which I amend." ------ morganherlocker Lot's of (mis)information floating around regarding CCPA. I recommend taking the time to read the actual text[1]. The text is not particularly long or dense. There has been a lot of speculation about complex compliance procedures, but the main thrust of the bill is to provide users with information about how their data is collected, who it is shared with, and the rights to prevent certain types of selling or sharing of said data. The leginfo site also includes non-partisan analysis (under the "Bill Analysis" tab) of the bill and amendments as it moves through the legislature, which is useful for getting an understanding of how specific issues are being considered and addressed. Something to consider is that bills change substantially through the amendment process, so often critiques you read are based off old versions of the text that have already been addressed. [1] [https://leginfo.legislature.ca.gov/faces/billTextClient.xhtm...](https://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=201720180AB375) ~~~ notfromhere The main problem is that the bill is rushed and the legal bits have a lot of ambiguity. source: CCPA and its potential compliance has been a big PITA ~~~ morganherlocker No argument there; just pointing out that many of the common complaints around ambiguity are explicitly addressed in the text of the bill already. ~~~ notfromhere They're really not - the definition of using California household vs resident creates a huge unenforceable gray area for compliance ~~~ morganherlocker Agree to disagree on this example I guess. "household" is referred to in the bill when defining re-identification, and this is an important improvement over the language in GDPR, especially when it comes to geolocation data, which is often sold at the household level (ie: Experian sells household level market segmentation profiles that tell you a lot about a person's behavior without directly linking to an individual). The only other place households are referred to is in the section defining which companies the rules apply to, which is also pretty straightforward in a plain reading. If a company's number of consumers, households, _or_ devices exceeds 50k, they qualify. > (B) Alone or in combination, annually buys, receives for the business’ > commercial purposes, sells, or shares for commercial purposes, alone or in > combination, the personal information of 50,000 or more consumers, > households, or devices. ------ throawayuk55po We need to have a conversation about jurisdictions in the digital age. The way governments have decided that having a website accessible in a country makes you liable to respect the law of this country is a convulted and hacky notion that has been accepted way too fast. The physical establishment rule was the only sound approach. The fact that some countries started to lose shouldn't have allowed them to rewrite the rules (especially in such a hacky manner). Can you imagine owning a grocery store and having to ask every customer their nationality to check which law you must follow to do business with them? Then multiply this hell by 10 and soon 1000 considering new laws created left and right and you have the environment these dishonest politicians have created. ~~~ FussyZeus > We need to have a conversation about jurisdictions in the digital age. The > way governments have decided that having a website accessible in a country > makes you liable to respect the law of this country is a convulted and hacky > notion that has been accepted way too fast. You know if you
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members of Elektro's Board. Firstly is to be mentioned that according to Elektro's By Laws, the Board may have a minimum of 4 and a maximum of 7 permanent members (one obligatorily must be elected by appointment of Elektros' employees) and a minimum of 2 and a maximum of 4 alternates (one obligatorily to act solely as alternate to the employees' representative at the Board) Permanent members: Diomedes Christodoulou (President) Orlando Goanz?lez Ricky Linn Waddell Geraldo Gon?alves Pereira (elected by appointment of Elektro's employees) Vacant (3) Alternate members: James Martin Bannantine Richard Allan Lammers Ricardo Louren?o Carneiro (alternate to Geraldo Gon?alves) Vacant (3) The election and/or dismissal of the Board members has to be decided by the shareholders of the company. Normally the election o the Board members takes place at the annual Ordinary Shareholder's meeting. (This year, our OGM is scheduled to take place on April, 29th.) However this matter can also be decided at any time via an Extraordinary Shareholder's Meeting that has to be called trough a Board Resolution that has to be publicized at the Official Gazette no later than 8 days prior to date of such EGM. Should the present number of the Board members be maintained (i.e 4 permanent and 3 alternates), the election of new members (from our side) will have to be made upon the resignation of those presently on seat. Should you deem necessary, please call me at your earliest convenience. Least but nol east As I vave mentined to you the other day, it is quite normal to appoint the senior legal council as an alternate to the permanent members of the Board so that he may legally be present at all the board meetings--- abstract: | The detection of exolife is one of the goals of very ambitious future space missions that aim to take direct images of Earth-like planets. While associations of simple molecules present in the planet’s atmosphere ($O_2$, $O_3$, $CO_2$ etc.) have been identified as possible global biomarkers, we review here the detectability of a signature of life from the planet’s surface, i.e. the green vegetation. The vegetation reflectance has indeed a specific spectrum, with a sharp edge around 700 nm, known as the “Vegetation Red Edge” (VRE). Moreover vegetation covers a large surface of emerged lands, from tropical evergreen forest to shrub tundra. Thus considering it as a potential global biomarker is relevant. Earthshine allows to observe the Earth as a distant planet, i.e. without spatial resolution. Since 2001, Earthshine observations have been used by several authors to test and quantify the detectability of the VRE in the Earth spectrum. The vegetation spectral signature is detected as a small ’positive shift’ of a few percents above the continuum, starting at 700 nm. This signature appears in most spectra, and its strength is correlated with the Earth’s phase (visible land versus visible ocean). The observations show that detecting the VRE on Earth requires a photometric relative accuracy of 1% or better. Detecting something equivalent on an Earth-like planet will therefore remain challenging, moreover considering the possibility of mineral artifacts and the question of ’red edge’ universality in the Universe. author: - Luc Arnold date: 'Received: 23 Feb 2007 - Revised: 26 Jun 2007' subtitle: 'A review of 2001 - 2006 works' title: Earthshine observation of vegetation and implication for life detection on other planets --- [example.eps]{} gsave newpath 20 20 moveto 20 220 lineto 220 220 lineto 220 20 lineto closepath 2 setlinewidth gsave .4 setgray fill grestore stroke grestore Introduction {#intro} ============ *Shall we be able to detect life on an unresolved Earth-like extrasolar planet ?* Future space missions like Darwin or TPF will provide us with the first images and low-resolution spectra of these planets, and the question of the presence or not of -ideally- an unambiguous biosignature or -more realistically- a set of possible biogenic spectral features in these data will undoubtedly feed an animate debate. Let us consider a unresolved extrasolar Earth-like planet imaged by a space-based high-contrast instrument, basically a telescope equipped with a coronagraph that blocks the stellar light by masking the star to allow the observation of the very faint planet near its parent star [^1]. The spectrum of the light reflected by the planet, when normalized to the parent star spectrum, gives the planet reflectance spectrum revealing its atmospheric and ground colour, if the latter is visible through a partially transparent atmosphere. Since the planet will remain unresolved (at least with the missions mentioned above), its spectrum will be spatially integrated (i.e. disk-averaged) for the observed orbital phase of the planet. *How would the spectrum of an unresolved Earth-like planet look like?* A way to answer this question is to consider how would look like the spectrum of our Earth if it would be observed from a very large distance, typically several parsecs. This can be done from a space probe traveling deep into the Solar System and looking back the Earth, as Voyager-1 did in 1990 (Fig. \[voyager\]) or Mars Express in 2003 (Fig. \[omega\]). Note also that an integrated Earth spectrum for a given phase of the planet and also for a given position of an observer far above the earth can also be done - in principle at least - by integrating spatially-resolved spectra from low-orbit satellites. ![Voyager-1 took this picture of Earth in February 1990 while it was traveling well beyond the orbit of Neptune. Voyager did not take a spectrum of this spatially unresolved view of its mother planet, but this picture illustrates how could look like an Earth-like extrasolar planet imaged in the visible domain by a future space observatory - a pale blue dot. Photo from http://photojournal.jpl.nasa.gov/catalog/PIA02228. Courtesy NASA/JPL-Caltech.[]{data-label="voyager"}](Earth_by_Voyager1_small.eps) ![Mars Express recorded the Earth spectrum with its OMEGA instrument in July 2003 while it was traveling to Mars. This picture illustrates how could look like an Earth-like extrasolar planet spectrum recorded with a high signal to noise ratio (figure adapted from http://mars.jpl.nasa.gov/express/newsroom/pressreleases/20030717a.html).[]{data-label="omega"}](Earth_spectrum_by_Omega_small.eps){width="1.\textwidth" height="7cm"} An alternative method to obtain the Earth averaged spectrum consists of taking a spectrum of the Moon Earthshine, i.e. Earth light backscattered by the non-sunlit Moon (Fig. \[moon\]). A spectrum of the Moon Earthshine directly gives the disk-averaged spectrum of the Earth at the phase seen from the Moon (since the Moon surface roughness “washes out” any spatial information on the Earth’s colour). ![The Moon, in a morning of September 1999, displaying its crescent, i.e. the sunlit part of the Moon (here overexposed), and also a bright Earthshine over the rest of the Moon disk, i.e. the non-sunlit Moon illuminated by a gibbous Earth. It seems that Leonardo Da Vinci has been the first who clearly understood the origin of the phenomenon of Earthshine when studying the geometrical relationship between the Earth, Moon and Sun [@welther99]. The spectroscopy of the Earthshine directly gives the disk-averaged spectrum of the Earth as seen from the Moon *(photo Luc Arnold)*.[]{data-label="moon"}](LUNE11LR.eps){width="50.00000%" height="6.5cm"} *What shall we look for in this spectrum ?* We shall first look for sets of molecules in the planet atmosphere (like oxygen and ozone) which may be biologic products or by-products. We shall also look for ground colours characteristic of biological complex molecules (like pigments in vegetation). Said in a more general manner, we shall look for missing photons used in a photosynthetic process occurring on the planet. The visible and near infra-red Earthshine spectra published to date clearly show the atmospheric signatures and, at least, tentative signs of ground vegetation which thus appears as an interesting potential global biomarker [@arnold02], [@woolf02], [@seager05], [@montanes05],\ [@montanes06], [@hamdani06]. The question of possible artifacts is of course of prime importance (see Sect. \[implication\]). Vegetation indeed has a high reflectivity in the near-IR, higher than in the visible by a factor of $\approx5$ ([@clark99], Fig. \[vegetation\_spectrum\]). This produces a sharp edge around $\approx 700\ \rm nm$, the so-called Vegetation Red Edge (VRE). An Earth disk-averaged reflectance spectrum is thus expected to rise by a significant fraction around this wavelength if vegetation is in view from the Moon when the Earthshine is observed. ![Reflectance spectra of photosynthetic (green)
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me. Normally, this wouldn’t be a problem--but I’m a writer on a serious deadline, and my editor is breathing down my neck for a romantic, Nicholas Sparks type love story. No pressure, right? That's how I find myself flying across the country to crash a wedding in the name of research, dress and heels stuffed into my small suitcase. It should be the easiest book research ever. Drinking some free champagne, basking in the love of two strangers, and tapping into my romantic side. That will be a breeze. I'm a pro. I can handle this. Until I mistakenly end up in the wrong hotel room, naked as the day I was born, with the sexiest human I have ever met staring me down, wondering what I'm doing taking a shower in his bathroom. I don't think calling it research will get me out of this pickle. PRE-ORDER NOW Crystal-blue ocean shines below me, and if I wasn’t so scared of Zoey and her repercussions for being late, I would take the time to appreciate Mother Nature. Instead I hurry into my room, flop my suitcase on my bed, unzip it, and grab my toiletries. Not taking a second longer, I strip down, leaving my gross airplane clothes on the floor, and practically skip to the shower where I stop mid stride. In the shower stall is a black razor, with accompanying shaving cream. That’s odd. Is that courtesy of the hotel? This place is fancy, but not that fancy. Spinning on my heel, I turn toward the sink behind me and spot a white and green toothbrush, tube of toothpaste, and men’s cologne. Shit, turning toward the room, my eyes frantically roam the space, spotting a black suitcase in the corner. Shit, shit, shit. Naked, I cover my breasts with my arm and open the closet door only to come face to face with a few hung-up shirts. Yup . . . I’m in someone else’s fucking room. And whoever this room belongs to is the neatest person ever because who honestly lines up there toothbrush and toothpaste tube perfectly on the counter? Reaching for the phone, I call down to the front desk. “Mr. Wilder, how can we assist you?” Oh yeah, totally not in the correct room. “Uh, yeah, hi, this is Rylee Ryan. I just checked in. I was given the key to room 625 and it seems to be occupied.” “Oh dear, let me check.” There is a pause on the phone and then the lady comes on the line again. “I’m terribly sorry, Miss. Ryan. We have you in room 626. Would you like to come down here and grab a new key?” Is she kidding? The trek it took to get over here ate up enough of my time. I can’t possibly take a shower if I have to run back to the lobby, grab a key, and run all the way back here. “Would you mind bringing it to room 625? I have dinner plans and have to get changed.” “Oh, of course. I’ll send someone up with a key right away.” “Thank you.” I hop around naked, eyeing my pukey clothes on the floor and the shower in the other room. Twisting my lip to the side, I try to decide what to do. I can be super quick, like really fucking quick. I just need to scrub the puke and throw on a dress, simple. Two minutes tops. The water doesn’t even have to be warm. I’ll write a polite note to Mr. Wilder—whoever that is—leave him five dollars as a kind gesture and quietly leave. No problem with that. Right? Right. Turning on the shower, I hop in before the water can warm up and hiss from the frosty temperature. I douse soap all over my hands and scrub my neck and body vigorously first, which normally I would wash my hair first but . . . puke. Once I’m satisfied with the amount of scrubbing, I wash my hair, condition it in a minute, do one more soap scrubbing all over my body before rinsing and turning the shower off. Two minutes. Just in case Mr. Wilder is sitting outside the bathroom, I peek my head out the door, towel wrapped around my body, and call out, “Hello?” When there is no response, I check that the coast is clear then strut to my suitcase and find a simple black sundress. Not bothering to look for underwear or a bra—I really don’t need one with my perky B-cups—I lay out my dress and dry off. Hopefully Mr. Wilder doesn’t mind me using one of his towels or his room for that matter. He’s probably some old dude away on his golfing vacation. I hope I don’t give him a heart attack. I drape my towel over the bed and run my hands through my naturally wavy, black hair. This will have to do. Picking up my towel one more time, I scrunch my hair, trying to soak up all the water just as the hotel door swings open, light blaring through, a tall, dark silhouette shadowed in the doorframe. I still, frozen from the tips of my toes to the hand scrunching a towel in my hair. Toned calves and legs are covered by black board shorts, slick to his thighs, a bulge prominent. Narrow waist where his board shorts ride low on his hips, a black shirt dancing across his broad chest, cinching sleeves cuffed over his biceps, and a V-neck providing a glimpse of how far his tan extends. Head cast down, eyes transfixed on his phone in front of him, he doesn’t notice the naked girl standing in the middle of his hotel room. He stuffs his keycard in his back pocket and looks up, startled. I scream. He grumbles something unintelligible as I point out the obvious. “Ahhh, my boobs are naked!” It might be a little concerning that I consider my boobs to be the only things naked at this point. As quickly as I can, I cover my body, towel making a poor attempt to hide my girly bits. The man turns away, covering his eyes with his arm while muttering, “Oh shit.” “What the hell do you think you’re doing?” I ask, struggling with my towel. I know damn well the man in front of me must be Mr. Wilder, and this is in fact his room, and I’m the one intruding, but I still feel the need to place the blame on him for walking in on me naked. “Grabbing my sunglasses,” he says, his voice terrified but also deep and rumbly. “What the hell are you doing here?” Still trying to cover myself, I scramble to grab my dress and back up to the bathroom. “Washing my neck,” I answer, nervously, boobs swaying with my erratic movements. Eyes still covered, he keeps his back toward me but straightens up. “Washing your neck? Is that code for some kind of weird Key West thing?” I back into the bathroom and make quick attempt of putting my dress over my head and righting it so everything is covered up. Hair still damp as well as my body, I step out into the room and clear my throat, dress sticking to my damp skin. “No, it’s not code for anything. I really had to wash my neck.” When he turns around, he eyes me up and down, his gaze curious and heated when he sees just how hard my nipples are from the cold shower . . . and the unexpected peep show. “I didn’t choose your room to take a shower in.” I move my suitcase to the floor and pull up the handle. “The hotel gave me the key to this room by mistake, and since I had puke on my neck from the airplane—long story—I decided to take a quick shower while I waited for my room. I apologize for taking up your space, but I think we’re skipping an important detail here.” I cock my hand on my hip. “You saw me naked.” “No, I didn’t,” he retorts rather quickly, despite the slow grin that spreads across his face. I’m calling bullshit. “You totally saw my boobs.” “I really didn’t. Your scream scared the shit out of me. I didn’t have enough time to see anything before you covered up.” Eyeing him suspiciously, I ask, “You promise you didn’t see anything?” “Promise.” Hmm. “Okay, because being hotel neighbors and all, that would be extremely awkward if you saw me naked.” “Good thing I didn’t then.” He rocks back on his heels, hands in his pockets, unsure of what to do. Finally he reaches out to the desk next to him and holds up his black Ray Bans. “Just needed my sunglasses.” About the Author: Born in New York and raised in Southern California, Meghan has grown into a sassy, peanut butter eating, blonde haired swearing, animal hoarding lady. She is
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minute. Sprinkle each bowl with the cheddar cheese garnish and broil under a hot broiler until melted, just before serving. Serve warm with freshly prepared, warm chips. ## MAGNOLIAS 185 East Bay Street, downtown (843) 577-7771 magnolias-blossom-cypress.com Founding Executive Chef: Donald Barickman Culinary Operations: Don Drake Executive Chef: Kelly Franz Donald Barickman is widely recognized as one of the leaders of Charleston's first restaurant culinary renaissance, which most agree began with the opening of Magnolias shortly after the calamity that was Hurricane Hugo in 1989. Ironically, the storm put Charleston on the national awareness map. Donald, a young chef and recent Culinary Institute of America grad at the time, turned heads and dropped jaws with his groundbreaking notion of serving grits—widely considered breakfast fare—all day long in a white linen restaurant. And he had the audacity to cook them with stock, cream, and butter. Creative work with Southern staples like rice, grits, corn, and beans, remains at the heart of the restaurant. These days the kitchen is run by a talented executive chef, Kelly Franz. Starting at Magnolias in 2003, she believes that consistency is the key to the restaurant's success. Franz stays true to the menu staples (like the fried green tomatoes) that many come to Magnolias to enjoy, while continuing to expand the menu with seasonally driven trends. "Magnolias has been home to me for over 13 years. I began working (here) in my second year of culinary school and have grown up in [this] kitchen with many of my coworkers alongside me. I am blessed to have found a restaurant that believes in creativity and tradition," says Franz. Loyal patrons populate the pretty, spacious restaurant decorated with swaths of the forged iron magnolias for which it's named. Culinary Operations Chef, Don Drake, also with the restaurant since its beginning, said the following Magnolias favorite came about from an overabundance of green tomatoes. "We tried out fried green tomatoes as a special. The recipe evolved from the tomatoes first being served with a rémoulade to the dish it is today. We thought the creaminess of the grits would be a nice contrast to the crunch of a fried green tomato, the country ham added some saltiness and the tomato chutney a touch of sweetness," says Drake. Make the tomato chutney a day or several ahead. Prepare the grits and finish the fried tomatoes, ham, and tomato butter while the grits are cooking. FRIED GREEN TOMATOES WITH CARAMELIZED ONION AND WHITE CHEDDAR GRITS, COUNTRY HAM ANd TOMATO CHUTNEY (MAKES 6 SERVINGS) 3 cups seasoned all-purpose flour (salt and pepper added to taste) 3 cups buttermilk 3 eggs 2 cups panko bread crumbs ¾ cup yellow cornmeal ⅓ cup julienned basil 18 slices green tomatoes, ¼ inch thick, about 5 whole tomatoes 4 cups canola oil Tomato Chutney (recipe follows) Caramelized Onion & White Cheddar Grits (recipe follows) Tomato Butter (recipe follows) 6 (1½ ounce) slices of country ham, halved This is a standard breading procedure that can be used for frying many kinds of vegetables. You'll need three separate containers or use three large freezer bags to save time on the cleanup. Place the seasoned flour in the first container or bag. In the second, mix the buttermilk and eggs together. In the third, mix the panko, cornmeal and basil. Evenly coat all tomatoes in the seasoned flour, shaking off the excess. Place in the buttermilk mixture, remove the tomatoes and shake off any excess. Place them in the final container of panko-cornmeal mixture, making sure to coat them well. (As you work to coat the tomatoes, try to keep one hand dry and use your other hand for the wet steps.) In a large skillet or deep fryer, heat the canola oil to 325°F and fry the tomatoes in small batches until golden brown, about 3–4 minutes. Place on a paper towel to drain and keep warm. For the tomato chutney: 2 cups granulated sugar 1 cup apple cider vinegar 3 cups julienned tomatoes, drained 1 cup julienned yellow onions 1 tablespoon minced jalapeno 1 teaspoons red pepper flakes Place sugar and vinegar in heavy-bottomed saucepot over medium-high heat and bring to a boil. Reduce the heat to a simmer and reduce the volume by half. Add remaining ingredients and cook an hour or so until it becomes syrup-like. Remember that it will thicken as it cools. After it cooks down, remove from heat and cool. (Note: This will make more chutney than you need for this recipe. Store in the refrigerator up to several weeks in sealed container). For the grits: 3 cups water 1 cup stone ground grits ½ cup heavy cream 1 small onion, julienned and caramelized in a small skillet with 1 teaspoon butter (Cook over medium high heat until golden brown). 1 cup grated white cheddar cheese Kosher or coarse sea salt and pepper to taste In a heavy-bottomed pot, bring the water to boil. Slowly stir in the grits and stir continuously for the first 5 minutes to prevent lumps. Turn the heat down to low and simmer for 30 minutes. Add the heavy cream and cook for 15 minutes more. The grits should be thick and plump, add more water or heavy cream if needed. Add the caramelized onion and white cheddar cheese. Cook 5 minutes more. Season to taste with coarse sea salt and pepper. Keep warm until ready to serve. For the tomato butter: 1 tablespoon olive oil 3 shallots 1 cup tomato juice ¼ cup whipping cream 3 sticks unsalted butter, cut into small pieces ¼ teaspoon salt Pinch ground white pepper Warm the olive oil in a heavy-bottomed saucepot over medium-high heat. Sauté the shallots until translucent. Add the tomato juice and reduce until it becomes bubbly and thick. Add the cream and reduce until thickened, stirring often. Turn the heat down and, stirring constantly, add the butter a little bit at a time until all is incorporated. Remove from heat and hold in a warm area until ready to serve. Putting it together: Choose any good country ham and allow 1½ ounces or pieces of thinly sliced ham per person. Sear the ham in a sauté pan. Place 6 appetizer size plates on the counter and in the center of each plate place a 3-ounce scoop of caramelized onion and white cheddar grits. Starting with a single slice of fried green tomato, top the grits with alternate slices of tomato and ham. Finish the stack with a slice of tomato. Crown the stack with a spoonful of tomato chutney. Finish the dish using a 2-ounce ladle to drizzle tomato butter around the outside of the plate. ## LITTLE JACK'S TAVERN 710 King Street, upper peninsula (843) 531-6868 littlejackstavern.com Neighbourhood, LLC Culinary Director: John Amato The latest cousin to this restaurant group (which also owns Monza, page 9, and Leon's, page 46), that has just the right knack for getting its restaurants' concept, décor, menu and deliciousness fully aligned, Little Jack's Tavern may be the best of the bunch. That is saying a lot, trust me. Named after a fictional boxer "Jack" who moved to Charleston in the 1940's when his prized boxing career ended, it embodies the mood and spirit of the American dream with a Big Apple spin. Soft and cozy, the banquettes are comfortably padded with horse-motif fabric cushions. At the center of it all is a bold, red bar with cubbies for housing all kinds of magnificent-looking Rat Pack-era cocktails served in sexy glasses by even sexier bartenders. On the menu, largely created by super-talent John Amata (a Johnson & Wales grad with previous stints at FIG (page 38), running a food truck/catering company, Park Cafe, and with Neighbourhood, LLC), expect a slew of nostalgic goodies including big, juicy steaks; the diminutive, flavor-packed, and dangerously addictive Tavern burger; a tender shrimp burger; and Amato's excellent riff on steak tartare. "The tarter is simple, tasty food and consistent. It's a great dish for sharing. It's not a classic with Dijon, olive oil, and the raw egg. It's more of a steakhouse style, classic French with caper vinaigrette, herbs, fish sauce, and red wine vinegar. The end result is a creamy type texture that we top with fried potato strings that we buy in bulk at the grocery store," says Amato. Simply delicious, just
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. You've never seen one? I will arrange it. And you'll meet my father. He is well over sixty, but spends his evenings in nightclubs.' He laughed and glanced at his wife. 'I like early nights. He has the energy.' The security and hospitality of the Chiongbians and a ship waiting: the contrast with the past month was complete. I soon found that the flamboyance of the tropical islands of the south, where you can so easily imagine that men are leopards in human skins, was muted here. Compared with Manila or at least the southern Philippines, Cebu is a quiet, unhurried place that pillows its cheek against the soft folds of a mountain range and seems to doze. Victor said, 'Anyone who says he's busy in Cebu is a liar. People work harder in Luzon [the northernmost of the Philippine Islands where Manila is], where life is more insecure. It is harder to find work there, and they are frequently visited by typhoons that sweep away hillsides, bridges, even dams. Cebu is a city of the semi-retired.' 'Yet from Cebu you and your father are running this great shipping line, which he built from nothing.' 'Oh, well....' I liked Victor's gentle, firm style and modesty as much as I came to like his generous, hardfisted and boastful father, William. Victor's house in the Cebu equivalent of Beverly Hills looked down from green lawns on Magellan's landing place. Here the explorer's three ships, _Trinidad,_ _Victoria_ and _Conception,_ arrived in April 1521, flying the flag of Spain. (He had found a sponsor in King Carlos after suffering poverty and scorn in the service of Portugal.) Here the noble and diplomatic Portuguese limped ashore – he had been badly wounded in a battle with the Moors – and made friends with Rajah Humabon, impressing him with the roar of his cannon and the thickness of his men's Spanish armour, receiving presents of gold, ginger, palm wine, fish and figs 'more than a foot long', according to his chronicler Antonio Pigafetta. Victor could also look down on the little island of Mactan, where, three weeks later, Lapu-Lapu's warriors killed Magellan and his landing party with rocks and bamboo spears. Magellan's peaceful wooing of the friendly rajahs lasted barely a month. Less than three weeks before the landing at Cebu, he and his dying crew had made their landfall at the uninhabited island of Homonhon at the mouth of the Leyte Gulf in the eastern Philippines. His men were sick and had been terribly weakened by the crossing of the Pacific. Pigafetta recounted: We [were] three months and twenty days without taking on board provisions or any other refreshment, and we ate only old biscuit turned to powder, all full of worms and stinking of the urine that the rats had made on it, having eaten the food. And we drank water impure and yellow. We ate ox hides, which were very hard because of the sun, rain and wind. On Homonhon, Magellan's polyglot crew – Spaniards, Greeks, Germans, Italians, French, Flemings and Malays – found freshwater springs, and the coconut milk refreshed them. They wooed the Tagalog-speaking islanders like suitors and brought ashore presents – 'red caps, mirrors, combs, bells and other things'. Magellan himself gave the local rajah, Calambu, a robe of yellow and red cloth and a fine red cap, and then, to the rajah's delight, suggested that they become blood brothers. They embraced and cut their wrists, letting their blood mingle according to the Malay custom of _casicasi._ A few days later, on Easter Sunday, Magellan invited the rajah and his brother to attend mass ashore. Kneeling in the sun, the rajahs copied the actions of the Portuguese captain and his crewmen, 'going on their knees with raised hands at the elevation of the Host'. As they did so, a salute from the guns of the three ships rolled across the bay. Magellan had already refused to accept a 'bar of massy [heavy] gold' and, in other ways, had shown the Filipinos that he was not there to plunder or harm them. As the result of such modest behaviour, the rajah volunteered to guide the three ships to the larger islands to the west, only asking Magellan to wait two days while his people took in their rice harvest. Thus it was that the King of Spain's little fleet came to Cebu and astonished the eyes of Rajah Humabon. Introduced by the friendly rajah from the Gulf of Leyte, Magellan made a Christian of Humabon almost at once, christening him 'Don Carlos' after the Spanish king. Within ten days Cebu was a Christian island. But the end of the idyll was not long in coming. A chief, a vassal of Humabon, arrived from the little island of Mactan, pleading for help against a rival chief named Lapu-Lapu. Magellan moved his ships across the narrow strait and disembarked a landing party in the shallow water of Mactan, Lapu-Lapu's capital. Tragedy followed because the guns of the ships were too distant to cover the landing. Lapu-Lapu's fifteen hundred warriors charged down to the shore hurling rocks, spears and arrows at Magellan's forty-nine men. Later, Pigafetta told the King of Spain that the captain 'ordered us to withdraw slowly, but the men fled while six or eight of us remained with him. As a good captain and a knight he still stood fast, fighting for more than an hour.' The end came when an islander jabbed at his face and Magellan thrust him through with his lance, leaving it in his body. He struggled to draw his sword, but a spear took him in the left leg and he fell face down. In the clear shallows, over sand as white as sugar, like the shallows I had waded through on the Sulu island, Lapu-Lapu's warriors finished him off. In crystal water Magellan died – 'Our mirror, our light, our comfort and our true guide.' Standing beside Victor and looking down on the narrow strait between Mactan and Cebu and the modern steel bridge arching over it, Jalah's wobbly chant came back to me from the _Allimpaya_ 's wheelhouse: 'Rajah Humabon make them veree happee, All people will baptize under the church of Christ... But Lapu-Lapu is veree bad. To drive Magellan to go back home... O, Mother, Mother, I am seek, Call the doctor veree queek....' My notes continue: Victor is dynamic and restless. Perhaps he alone is a busy man in Cebu. On his farm on the western side of the island, he walks fast and determinedly through the acres of trees and cultivation. He has a ranch in Mindanao, he says, but doesn't go there now because of the violent deeds of the Moros. Instead, to get away from it all he goes fishing and shooting on Palawan Island. Here he has knobbly green hills to stride over that are cultivated with coconuts, mangoes, bananas and rice. Plans fill his head: for pigs and pig manure, the marketing of sweet lemons, a distillery. Victor is not a particularly big man, but he orders huge meals – I suspect only for my benefit – and gulps them down. We drink at least two sorts – one sweeter than the other – of home-made _tuba,_ the fermented sap of the coconut palm, coloured and slightly embittered by powdered tanbark, the mangrove husk that the _Allimpaya_ carried from Sandakan. It's good the dry kind especially, and costs less than 25 pence a gallon. In the market of Asturias there are slabs of dolphin meat, dark red like horse's liver, and manta-ray steaks. The local villages are of wood, houses bright with coconut shells suspended by thin chains from their gables holding sprays of orchids. Their plaster-fronted, ornate Spanish churches remind me of the flamboyant birthday-cake churches of Tuticorin in southern India. To reach Asturias we have to pass the Atlas copper mine – 'the biggest in all Asia,' says Victor. It is like a huge quarry, an ugly dried-up wound in the landscape. Foliage for acres around is grey with dust from it. It is the biggest man-made wound in Asia. # Thirty Six A small wicket gate leading to the cockpit announced that ringside seats cost twenty pesos and the balcony ten pesos, or rather more than fifty pence. From the car park to the cockpit gate dozens of men and boys shifted from foot to foot, lovingly stroking the backs of roosters they held in the crooks of their arms like bagpipes. The bound legs of the roosters hung down, their long, glossy green-black or white
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be able to infer reliable FP coefficients, especially for $\xi_M$, when considering only [BL Lac]{} objects. ### Doppler Boosting {#sec:dr7blDoppler} Throughout, we have assumed that Doppler beaming only affects [BL Lac]{} objects, and that, to first order, Doppler beaming does not largely affect the best-fit coefficients. That is, we assume that optically thick and optically thin synchrotron emission are beamed by approximately the same amount, so beaming primarily only moves [BL Lac]{} objects up or down the best-fit line in Figure \[fig:fp\] [also see @falcke04; @heinz04_beaming; @li08]. We note that @landt02 find no *statistical* evidence that more weakly beamed [BL Lac]{} objects (like the 55 [BL Lac]{} objects used in this work) have significantly different Doppler factors in the radio and X-ray. Still, our assumption that the Doppler factor is similar in different wavebands is unlikely to be strictly true, and different Doppler factors probably contribute to some of the observed scatter. We test the effect of Doppler boosting by debeaming the SDSS [BL Lac]{} objects, assuming $\delta=7$ , and thus reducing their radio and “X-ray luminosities” by a factor $\delta^{2+\alpha_\nu}$ [@lind85; @urry95]. We assume $\alpha_{\nu}=-0.27$ in the radio, $\alpha_{\nu}=0.6$ for KFC-like and SED-based X-ray luminosities, and $\alpha_{\nu} = 1.5$ and $1.05$ for HBL and LBL “real X-ray luminosities", respectively. The debeamed [BL Lac]{} objects have similar luminosities as FR I galaxies, as expected from the standard AGN unification paradigm (see Figure \[fig:fp\]). We then regress the KFC+SDSS, KFC+SDSS-HBL, and KFC+SDS-LBL samples with the debeamed [BL Lac]{} luminosities. As long as our “X-ray luminosities" are probing optically thin synchrotron radiation, debeaming the [BL Lac]{} luminosities does not significantly change the best-fit regression coefficients (see the coefficients for all three “SED-based" regressions and the “KFC-like" regression for the KFC+SDSS-HBL sample in Table \[tab:sdssbayes\]). We thus conclude that Doppler beaming does not strongly influence the FP regression. Other systematics, such as making sure one probes consistent regions of accreting black hole SEDs across the mass scale, are likely more important. For example, when our “X-ray luminosities” instead primarily probe synchrotron cooled emission or SSC/EC, as for the “real X-ray" regressions, then debeaming the [BL Lac]{} objects does change the best-fit FP slopes. However, these regressions are not physically meaningful because we are probing different SED regions for different black hole masses. Debeaming synchrotron cooled“X-ray luminosities" would move [BL Lac]{} objects down the synchrotron cooled radio/X-ray/mass correlation predicted by @heinz04, and not the “optically thin synchrotron" correlation followed by the lower-mass contracted KFC subsample. Thus, debeamed synchrotron cooled or SSC/EC X-rays will bias the best-fit FP regression by a different amount than beamed X-rays. ![image](f8) Discussion {#sec:disc} ========== Comparison of the Discovery Papers – Two Fundamental Planes? {#sec:merloniVsFalcke} ------------------------------------------------------------ A few more comments on the two discovery papers and their inferred mechanisms for X-ray emission are in order. Because favors a RIAF and a jet, there is sometimes an understandable but unfair perception in the literature that the two papers contradict each other. However, also outline how jet X-rays can lead to the FP, and in that case they predict coefficients similar to that of . There are likely at least two FPs[^14], and regressions of the FP only test the “average” emission mechanism. The situation is actually even more complicated, in that every source follows its own FP to some level due to different values of $\alpha_R$, $p$, and $q$, which contributes to the observed intrinsic scatter about the FP. The apparently discrepant conclusions in the two discovery papers are an artifact of the samples used in each paper to test the FP. considered only low-accretion rate (i.e., jet-dominated) sources, while assembled a more diverse sample; the sample mixes some jet and some RIAF X-ray dominated black holes, which naturally increases the intrinsic scatter. However, exclude [BL Lac]{} objects, so their most-massive SMBHs include almost exclusively more luminous quasars that are well accepted to have coronal dominated X-ray emission. Given that those AGN provide the largest dynamic range and considering the previous section’s results, it is not surprising that the M03 regression favors the RIAF models (albeit with large intrinsic scatter). That the FP coefficients are sensitive to the sample adopted in the two discovery papers (especially lower accretion rate objects seeming to favor jet X-rays), supports the idea that AGN mimic accretion states of GBHs. ’s reanalysis of the and samples seems to confirm the conclusions of the discovery papers. However, the coefficients found by for the two samples (using the same Merit function technique) are not remarkably different when considering the error bars; for the sample, $\left(\xi_R\right)_{M03} = 1.45\pm0.17$ and $\left(\xi_M\right)_{M03}=-0.99\pm0.22$; for the sample, $\left(\xi_R\right)_{F04}=1.41\pm0.11$ and $\left(\xi_M\right)_{F04}=-0.87\pm0.14$. It is thus an interesting “conspiracy” (as call it) that the two emission mechanisms yield FPs with so much overlap. This is in large part due to optically thin jet synchrotron emission and RIAF X-ray emission both approximately following $L_X\sim M \dot{m}^2$ [@falcke95; @markoff03]. Statistical techniques more sophisticated than the Merit function are necessary to regress the FP with high enough accuracy to distinguish between the two radiation mechanisms. Comments on Other FP Studies ---------------------------- ### @yuan09 There is a well-established global radio/X-ray correlation followed by quiescent (i.e., hard state) GBHs: $\log L_R \sim 0.7 \log L_X$ [@corbel03; @gallo03]. @yuan09 claim this correlation is best explained if the X-rays are predominantly from the accretion flow. This claim is based on @yuan05, who model emission from accreting black holes with components from both a jet and from an ADAF. Their ADAF accounts for the effects of outflows and convective instabilities, and it includes emission from synchrotron and bremsstrahlung processes and their thermal Comptonization. @yuan05 argue that only when the X-ray luminosity drops below a critical X-ray luminosity, $L_{X,crit} \sim10^{-5}$– $10^{-6}~L_{Edd}$, can jet synchrotron instead dominate the observed X-ray emission. They predict that the $\log L_R \sim 0.7 \log L_X$ correlation will then steepen to $\log L_R \sim 1.23 \log L_X$, as the X-ray emission switches from being ADAF to jet dominated.[^15] @yuan09 use a sample of 22 very low-accretion rate AGN with $L_X < 10^{-6}~L_{Edd}$ (i.e., below $L_{X,crit}$) to regress the FP and test the prediction of @yuan05. They find $\log L_R \sim (1.22 \pm 0.02) \log L_X + (0.23 \pm 0.03) \log {M_{\rm BH}}$, in excellent agreement with @yuan05.[^16] @yuan09 do not include any AGN with $L_X \geq L_{X,crit}$, but they note that the accreting black holes in the sample used by all have $L_X>L_{X,crit}$. find a shallower FP regression for their more luminous accreting black holes \[$\log L_R\sim (0.60^{+0.11}_{-0.11}) \log L_X + (0.78^{+0.11}_{-0.09}) \log {M_{\rm BH}}$\], which is consistent with the radio/X-ray correlation for quiescent GBHs (i.e., $\log L_R \sim 0.7 \log L_X$; @gallo03). The conclusion of @yuan09 therefore supports @yuan05, that the radio/X-ray correlation of quiescent black holes described in @gallo03 is due to the jet in the radio and inverse Compton in the X-ray. However, below a critical luminosity, the radio/X-ray correlation steepens as the X
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where a judge might take a more surgical look at laws and sentencing. There are also some changes to plea agreements, including mandatory minimum sentences in plea agreements, whereas parties could previously agree on light punishments or a judge could hand one down. A mandatory minimum sentence in a plea deal could satisfy a victim’s desire to see justice while avoiding the spectacle of a trial. “There’s some assurance for a commander that there would be some sentence,” Root said, adding, “and I think sometimes maybe a victim might be supportive of a plea agreement.” For cases that do make it to trial, there are some significant changes to jury panel sizes. A general court-martial used to require at least five panel members, Root said, but the number usually depended “on how many seats are in the panel box at a particular location," and two-thirds finding guilty needed to convict. Now it’s regulated: Four for a special court-martial, eight for a general court-martial, and 12 for a capital general court-martial, with three-quarters to convict. There are yet more changes for post-trial proceedings. Service members found guilty at trial can elect to be sentenced either by a judge alone or by a panel, as is done now. Once a sentence is handed down, if it calls for a dishonorable or bad-conduct discharge, more than one year in prison, dismissal of an officer or death, the case is automatically sent to an appeals court for review. But that process couldn’t start until a convening authority approved the sentence, and that wouldn’t happen until the court reporter completed a full transcript of the trial. It could take months and months, Root said. Now, an audio recording of a trial is considered a sufficient record of trial, and courts-martial are considered closed after a judgment is entered — in more like 45 to 60 days, she said. Court overturns rape conviction, citing unlawful influence from former top Air Force leaders An airman's 2014 conviction of rape and assault and battery was overturned Monday after an appeals court ruled an embattled general's decision to move forward on the case represented "unlawful command influence." In May 2017, the Armed Forces Court of Appeals overturned the 2015 rape conviction of Airman Rodney Boyce. The hope is that speeding up the process to end a trial will also speed up the appeals process, possibly cutting down the time the accused spends in confinement, waiting on an appeal. “If that happens faster, that means my client has a better chance of getting an acquittal down the road,” Timmons said.Le ministre de la Justice, Jean-Jacques Urvoas. Le 23 février 2017. / AFP PHOTO / Philippe LOPEZ — AFP Jean-Jacques Urvoas va-t-il être renvoyé devant la Cour de justice de la République ? Le parquet général de la Cour de cassation a requis, ce lundi, le renvoi de l’ancien garde des Sceaux pour « violation du secret » dans une enquête visant le député Thierry Solère, a-t-il annoncé dans un communiqué. L’ancien ministre socialiste est accusé d’avoir transmis, en mai 2017, à Thierry Solère, député des Hauts-de-Seine, ex-Républicains qui a rejoint La République en marche, des éléments sur une enquête le concernant. Le procureur général François Molins, qui assure le rôle du ministère public auprès de la Cour de justice de la République, la seule habilitée à juger des membres du gouvernement pour des faits commis dans l’exercice de leurs fonctions, a réclamé la tenue de ce procès. Thierry Solère a dû renoncer à son poste de questeur de l’Assemblée nationale Il revient désormais à la commission d’instruction de la CJR, composée de magistrats de la Cour de cassation, de décider d’un éventuel procès contre Jean-Jacques Urvoas. L’ancien locataire de la place Vendôme est soupçonné d’avoir transmis à Thierry Solère, les 4 et 5 mai 2017, « une fiche d’action publique établie par la direction des affaires criminelles et de grâces rendant compte de l’état et des perspectives d’une enquête préliminaire le mettant en cause, puis un courriel d’actualisation de cette fiche », rappelle le communiqué du parquet général. Thierry Solère, qui a dû renoncer fin 2017 à son poste de questeur de l’Assemblée nationale, est visé depuis le 6 septembre 2016 par une enquête préliminaire du parquet de Nanterre pour « fraude fiscale, blanchiment, corruption, trafic d’influence et recel d’abus de biens sociaux ». Dans ce cadre, une perquisition à son domicile en décembre 2017 avait permis la découverte dans son téléphone d’un message envoyé par Jean-Jacques Urvoas entre les deux tours de l’élection présidentielle, avait révélé à l’époque le Canard Enchaîné. La suppression de la Cour de justice de la République envisagée La procureure de Nanterre avait transmis ces informations le 5 décembre 2017 au procureur général près la Cour de cassation, qui avait saisi le mois suivant la commission d’instruction de la Cour de justice de la République. Le 20 juin, Jean-Jacques Urvoas avait été mis en examen pour « violation du secret ». « Je conteste avec détermination une quelconque violation, dans l’exercice de mes fonctions ministérielles, d’un secret protégé », avait-il réagi à l’issue de son audition. Cette affaire suit son cours alors que la suppression de la Cour de justice de la République est envisagée dans le cadre d’une réforme constitutionnelle, qui a été reportée sine die.Car accidents as a method of suicide: a comprehensive overview. The research literature provides evidence on the possible link between single-car accident drivers and suicidal intent, and some scholars have stressed the role of unconscious suicidal motivations in some single-car accidents. This paper review relevant literature on the topic and sheds light on neglected factors that may play a central role in reducing the number of deaths due to car accidents. We performed careful PubMed, and PsycInfo searches to identify all papers and book chapters in English during the period 1955-2011. Our overview of the literature indicates that above 2% of the traffic accidents are suicide behaviors. However, the phenomenon may be underreported, considering that suicides by car accidents may be reported as accidental in the national statistics. On the other hand, the association between accident-pronesses and unconscious self-destructive impulses is an issue that is difficult to solve.Reuters Now Argentina's Fernandez indicted for treason Posted A federal judge in Argentina indicted former President Cristina Fernandez for treason and asked for her arrest for trying to cover up Iran's possible role in the 1994 bombing of a Jewish community center that killed 85 people./* Copyright (c) 2010 Fizians SAS. <http://www.fizians.com> This file is part of Rozofs. Rozofs is free software; you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, version 2. Rozofs is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details. You should have received a copy of the GNU General Public License along with this program. If not, see <http://www.gnu.org/licenses/>. */ #ifndef RUC_OBSERVER_API_H #define RUC_OBSERVER_API_H #include <rozofs/common/types.h> #include "ruc_common.h" #include "ruc_list.h" // 64BITS typedef void (*ruc_observer_cbk) (uint32_t userRef, uint32 srvParam); typedef void (*ruc_observer_cbk) (void * userRef, void *srvParam); #define ruc_observer_attachEventMACRO(servAttachFunc,event,priority,userRef,cbk) servAttachFunc(#cbk,event,priority,userRef,cbk) #define ruc_observer_attachMACRO(servAttachFunc,priority,userRef,cbk) servAttachFunc(#cbk,priority,userRef,cbk) /*---------------------------------------------- ** init of the observer service **---------------------------------------------- **
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budgetary constraints and/or imperfections in Medicare or Medicaid data used to calculate these rates. Net prices for products may be reduced by mandatory discounts or rebates required by government health care programs or by any future relaxation of laws that restrict imports of certain medical products from countries where they may be sold at lower prices than in the United States. There have been, and we expect that there will continue to be, federal and state proposals to constrain expenditures for medical products and services, which may affect payments for any of our approved products. The Centers for Medicare and Medicaid Services frequently change product descriptors, coverage policies, product and service codes, payment methodologies and reimbursement values. Third-party payors often follow Medicare coverage policy and payment limitations in setting their own reimbursement rates and may have sufficient market power to demand significant price reductions. As a result of actions by these third-party payors, the health care industry is experiencing a trend toward containing or reducing costs through various means, including lowering reimbursement rates, limiting therapeutic class coverage and negotiating reduced payment schedules with service providers for drug products. Our inability to promptly obtain coverage and profitable reimbursement rates from government-funded and private payors for any approved products could have a material adverse effect on our operating results and our overall financial condition. Recent federal legislation will increase the pressure to reduce prices of pharmaceutical products paid for by Medicare, which could adversely affect our revenues, if any. The Medicare Prescription Drug Improvement and Modernization Act of 2003, or MMA, changes the way Medicare will cover and pay for pharmaceutical products. The legislation expanded Medicare coverage for drug purchases by the elderly and eventually will introduce a new reimbursement methodology based on average sales prices for drugs. In addition, this legislation provides authority for limiting the number of drugs that will be covered in any therapeutic class. As a result of this legislation and the expansion of federal coverage of drug products, we expect that there will be additional pressure to contain and reduce costs. These cost reduction initiatives and other provisions of this legislation could decrease the coverage and price that we receive for any approved products and could seriously harm our business. While the MMA applies only to drug benefits for Medicare beneficiaries, private payors often follow Medicare coverage policy and payment limitations in setting their own reimbursement rates, and any reduction in reimbursement that results from the MMA may result in a similar reduction in payments from private payors. Risks Related to Our Dependence on Third Parties We may not be able to execute our business strategy if we are unable to enter into alliances with other companies that can provide capabilities and funds for the development and commercialization of our drug candidates. If we are unsuccessful in forming or maintaining these alliances on favorable terms, our business may not succeed. We have entered into a collaboration arrangement with Gilead Sciences for the development and commercialization of certain of our HCV compounds involving NS4A antagonism, and we may enter into additional collaborative arrangements in the future. For example, we may enter into alliances with major biotechnology or pharmaceutical companies to jointly develop specific drug candidates and to jointly commercialize them if they are approved. In such alliances, we would expect our biotechnology or pharmaceutical collaborators to provide substantial funding, as well as significant capabilities in clinical development, regulatory affairs, marketing and sales. We may not be successful in entering into any such alliances on favorable terms, if at all. Even if we do succeed in securing such alliances, we may not be able to maintain them if, for example, development or approval of a drug candidate is delayed or sales of an approved drug are disappointing. Furthermore, any delay in entering into collaboration agreements could delay the development and commercialization of our drug candidates and reduce their competitiveness even if they reach the market. Any such delay related to our collaborations could adversely affect our business. If a collaborative partner terminates or fails to perform its obligations under agreements with us, the development and commercialization of our drug candidates could be delayed or terminated. If Gilead Sciences or another, future collaborative partner does not devote sufficient time and resources to collaboration arrangements with us, we may not realize the potential commercial benefits of the arrangement, and our results of operations may be adversely affected. In addition, if any existing or future collaboration partner were to breach or terminate its arrangements with us, the development and commercialization of the affected drug candidate could be delayed, curtailed or terminated because we may not have sufficient financial resources or capabilities to continue development and commercialization of the drug candidate on our own. Under our collaboration agreement with Gilead Sciences, Gilead Sciences may terminate the collaboration for any reason at any time upon 120 days notice. If Gilead Sciences were to exercise this right, the development and commercialization of our HCV compounds would be adversely affected. Much of the potential revenue from our existing and future collaborations will consist of contingent payments, such as payments for achieving development milestones and royalties payable on sales of drugs developed. The milestone and royalty revenues that we may receive under these collaborations will depend upon our collaborator’s ability to successfully develop, introduce, market and sell new products. In addition, our collaborators may decide to enter into arrangements with third parties to commercialize products developed under our existing or future collaborations using our technologies, which could reduce the milestone and royalty revenue that we may receive, if any. In many cases we will not be involved in these processes and accordingly will depend entirely on our collaborators. Our collaboration partners may fail to develop or effectively commercialize products using our products or technologies because they: • decide not to devote the necessary resources due to internal constraints, such as limited personnel with the requisite scientific expertise, limited cash resources or specialized equipment limitations, or the belief that other drug development programs may have a higher likelihood of obtaining regulatory approval or may potentially generate a greater return on investment; • do not have sufficient resources necessary to carry the drug candidate through clinical development, regulatory approval and commercialization; or • cannot obtain the necessary regulatory approvals. In addition, a collaborator may decide to pursue a competitive drug candidate developed outside of the collaboration. In particular, Gilead Sciences, our collaborator for our chronic hepatitis C program, currently is developing other products for the treatment of chronic hepatitis C, and the results of its development efforts could affect its commitment to our drug candidate. If our collaboration partners fail to develop or effectively commercialize drug candidates or drugs for any of these reasons, we may not be able to replace the collaboration partner with another partner to develop and commercialize a drug candidate or drugs under the terms of the collaboration. We may also be unable to obtain, on terms acceptable to us, a license from such collaboration partner to any of its intellectual property that may be necessary or useful for us to continue to develop and commercialize a drug candidate. We rely on third parties to conduct our clinical trials, and those third parties may not perform satisfactorily, including failing to meet established deadlines for the completion of such trials. We do not have the ability to independently conduct clinical trials for our drug candidates, and we rely on third parties such as contract research organizations, medical institutions and clinical investigators to enroll qualified patients and conduct our clinical trials. Our reliance on these third parties for clinical development activities reduces our control over these activities. Accordingly, these third-party contractors may not complete activities on schedule, or may not conduct our clinical trials in accordance with regulatory requirements or our trial design. To date, we believe our contract research organizations and other similar entities with which we are working have performed well. However, if these third parties do not successfully carry out their contractual duties or meet expected deadlines, we may be required to replace them. Although we believe that there are a number of other third-party contractors we could engage to continue these activities, it may result in a delay of the affected trial. Accordingly, our efforts to obtain regulatory approvals for and commercialize our drug candidates may be delayed. We currently depend on third-party manufacturers to produce our preclinical and clinical drug supplies and intend to rely upon third-party manufacturers to produce commercial supplies of any approved drug candidates. If in the future we manufacture any of our drug candidates, we will be required to incur significant costs and devote significant efforts to establish and maintain these capabilities. We have relied upon third parties to produce material for preclinical and clinical testing purposes and intend to continue to do so in the future. We also expect to rely upon third parties to produce materials required for the commercial production of our drug candidates if we succeed in obtaining necessary regulatory approvals. If we are unable to arrange for third-party manufacturing, or to do so on commercially reasonable terms, we may not be able to complete development of our drug candidates or market them. Reliance on third-party manufacturers entails risks to which we would not be subject if we manufactured drug candidates ourselves, including reliance on the third party for regulatory compliance and quality assurance, the possibility of breach of the manufacturing agreement by the third party because of factors beyond our control and the possibility of termination or nonrenewal of the agreement by the third party, based on its own business priorities, at a time that is costly or damaging to us. In addition, the FDA and other regulatory authorities require that our drug candidates be manufactured according to current good manufacturing practice regulations. Any failure by us or our third-party manufacturers to comply with current good manufacturing practices and/or our failure to scale up our manufacturing processes could lead to a delay in, or failure to obtain, regulatory approval of any of our drug candidates. In addition, such failure could be the basis for action by the FDA to withdraw approvals for drug candidates previously granted to us and for other regulatory
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's makeup. Thus, we assume that _A_ knows that _B_ prefers CapB to WarA (later we relax this condition) but does not know whether _B_ prefers Nego to CapA. If _A_ and _B_ are pacific doves but each is uncertain of the other's dovishness, then _A_ will gamble on negotiating if the expected utility of the lottery in which _A_ offers to negotiate—not knowing whether _B_ will also reject the use of force or will exploit its momentary advantage—is superior for _A_ to choosing the use of force: The benefits from negotiation are worth the risk of exploitation for _A_ under rather constrained circumstances. For instance, the critical threshold value for _A_ 's belief that _B_ is a dovish type, π*A, increases as _A_ 's expected domestic penalties for using force decrease. Indeed, if ϕA ≤ [(1 − PA)υA(ΔA − ΔB)]/PA, then no level of belief about _B_ by _A_ is sufficient to warrant risking exploitation. _A_ will use force. In this case, domestic political considerations are central in determining a critical foreign policy choice. Actor _B_ appears to be less constrained. For _B_ , the risk of exploitation is worthwhile so long as the gamble that _A_ will choose to be conciliatory versus the danger that _A_ will force a capitulation by _B_ is superior to acquiescing to _A_ 's initial demand: 4.2: Pacific dove _A_ 's critical belief threshold. This ratio is always less than 1.0, ensuring that πB at least can always hold a feasible value. For dove _B_ , domestic factors apparently do not enter into this foreign policy decision. The domestic cost term appears nowhere in expression 4.2. Of course, war is an impossibility if neither _A_ nor _B_ would retaliate if attacked. But how likely is cooperation between such pacific doves if each is uncertain only of the other's willingness to refrain from exploitation in favor of negotiation? Just how willing are they to gamble on the dovishness of the rival? We evaluate the relation between dovishness and the prospects of cooperation as a function of the probability of success by _A_ and its coalition of supporters. figure 4.2 and 4.3 plot the functional form of expressions (4.1) and (4.2) with respect to the subjective probability of success. The figures map the critical thresholds π*A and π*B for increasing values of PA (as subjectively estimated by _A_ and _B_ , respectively). _B_ gambles on _A_ 's dovishness so long as its belief is above the critical threshold value depicted in figure 4.3 and delineated in expression 4.2. Likewise, _A_ gambles on _B_ 's goodwill provided its actual belief about _B_ is above the critical threshold line depicted in figure 4.2 and derived from expression 4.1. For _B_ to gamble means that it does not acquiesce to _A_ 's initial demand. For _A_ to gamble means that it offers to negotiate, risking that _B_ will seize the initiative and exploit _A_ 's offer. Because both parties are actually doves, if both gamble, then, cooperation and negotiation ensue. However, if either chooses not to gamble, then coercion ensues. 4.3: Pacific dove _B_ 's critical belief threshold. If _B_ does not gamble on _A_ 's dovishness, then the resultant coercion is tacit and nonviolent. _B_ acquiesces under the belief that _A_ will exploit _B_ if the opportunity arises. If _A_ does not gamble and _B_ does, then _A_ , despite its distaste for exploiting _B_ , coerces _B_ into capitulating to _A_ 's demand under the perhaps mistaken belief that the alternative was for _A_ to be coerced. As is evident from figures 4.2 and 4.3, one or another form of coercion may be likely. What is more, there is a wide range of circumstances in which pacific dove _A_ 's coercion of _B_ involves violence. The case of two pacific doves is instructive. As figures 4.2 and 4.3 reveal, such a dovish _A_ is more and more willing to gamble on _B's_ goodwill as _A_ 's probability of success (that is, _A_ 's power or that of _A_ 's coalition of supporters) increases, but _B_ is less and less inclined to gamble on _A_ 's goodwill under these conditions. Thus, _B_ is increasingly willing to submit to tacit coercion as _A_ gets stronger, whereas _A_ is increasingly inclined to resort to force rather than risk exploitation as it gets weaker. The intuition behind these results is straightforward despite their seemingly counterintuitive nature. The stronger _A_ is relative to _B_ , the worse _B_ can expect to do even if the two nations reach a negotiated settlement. Therefore, because negotiation is not all that attractive, it is not worth _B_ 's while to risk exploitation and the outcome of capitulation. As _B_ 's power (or, more precisely, its own power and that of its coalition of supporters) increases relative to _A_ 's, the value of a negotiated settlement also rises for _B_ , making the gamble more attractive. At the same time, the value of the gamble becomes less attractive for _A_ because _A_ does not stand to gain much from a negotiated settlement. _A_ simply does not bring much leverage to the bargaining table. Having less power inclines _A_ not to risk being exploited by _B_ , for the positive side of the risk (that is, a negotiated settlement) is of diminishing worth. Therefore, _A_ becomes more inclined to take an action it finds distasteful: attacking _B._ By gambling, _A_ can end up doing poorly in a negotiation or, even worse, can end up being attacked and having to capitulate (remember _A_ is a _pacific_ dove). Weak _A_ 's only real chance at a significant benefit arises, paradoxically, if _A_ attacks _B_ and _B_ turns out to be the pacific type who gives in. That is _A_ 's incentive for using force when _A_ is weak and pacific. The more inclined one pacific dove is to gamble on the other's goodwill, the less so inclined is the other pacific dove. Depending on the magnitude of the expected costs of coercion, the inverse relations between _A_ 's and _B_ 's willingness to take a chance on the other's goodwill can be a recipe for substantial coercion. figure 4.2 and 4.3 suggest counterintuitive, testable hypotheses that represent modifications of Cooperation Proposition 4.1 under conditions of uncertainty. COOPERATION PROPOSITION 4.1A. _Expression 4.1 indicates that if A and B are doves uncertain of each other's type and if B is not expected to retaliate if attacked, then the coercive use of force by A is most likely if A is weak compared to B. Weak dovish As are more likely to initiate violence than are strong dovish As, with the likelihood diminishing asymptotically as A's subjective estimate of its probability of success increases._ COOPERATION PROPOSITION 4.1B. _Expression 4.2 indicates that if A and B are doves uncertain of each other's type and if B is not the type that retaliates if attacked, then the likelihood that B acquiesces to A's initial demand increases exponentially as B's subjective estimate of A's probability of success in a confrontation with B increases_. We subject these two propositions to empirical tests. We cannot measure the actual beliefs of _A_ or _B_ about the other's type, although we do estimate their beliefs about _A_ 's probability of success in a confrontation. Also, we estimate for each side whether it was a pacific dove. We assume that true beliefs, on average, are more likely to fall above the critical threshold, facilitating cooperation, as the critical threshold value falls lower and lower. That is, the lower the critical threshold, the more likely that, on average, the required level of belief is satisfied. Then we can test the central tendency of the expectations from propositions 4.1a and 4.1b. We define all of the necessary variables—whether _A_ and _B_ are doves, whether _B_ is a tough, retaliatory dove or a pacific, exploitable dove, and whether _A_ has much probability of success—in accordance with the procedures described in appendix 1. As figure 4.2 indicates, _A_ 's gambling threshold falls asymptotically as _A_ 's power rises. We capture this nonlinear, asymptotic expectation by taking the logarithm of side _A_ 's probability of success. Our test of proposition 4.1a, then, is a logit analysis. The dependent variable, ViolentA, recognizes that the theory predicts the conditions under which _A_ will use force. This variable is coded as 1.0 so long as _A_ uses force, regardless of _B_ 's ultimate response. The
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construction industry fatalities in 2003 alone[@r3]^)^. In Korea, the construction industry was responsible for greatest number of fatalities among all industries[@r4]^)^. Data from a number of industrialized countries show that construction workers are 3 to 4 times more likely than other workers to die from accidents at work[@r5]^)^. In the developing world, the risks associated with construction work may be 3 to 6 times greater than other industries. The data from National Safety Council of the U.S. showed that the construction industry accounted for 5% of all workers, but 20% of all fatalities and 9% of all serious injuries and disabilities[@r6]^)^. Similarly, in the U.K. construction industry accounted for five times more fatalities than the average of other industries, and twice the number of injuries[@r7], [@r8]^)^. In Turkey, the 2011 official statistics reveal that construction accounts for 6.3% of the labour force and 33.5% (570 in 1700) of total fatalities for all industries. The high rate of fatalities in the construction industry is consistently observed in the years between 2000 and 2011[@r9]^)^. In 2011, the construction industry accounted for 6% of the GNP with and 8.5% growth from previous year and 1.581 million individuals were employed by the construction industry. Construction Industry Employment Index for Buildings has increased from 69.2 to 75.0 (that is 75 percent of construction workforce easily find jobs) and for Other Structures has increased from 98.9 to 104.6. As these figures show, the construction industry is playing a significant role in the economic development of Turkey[@r10]^)^. However, the industry has the reputation of being one of the most unsafe industries in Turkey and compared with other industries. Literature Review on Accident Analyses in the Construction Industry {#s2} =================================================================== Previous research on construction fatalities has focused on general causes or causal relationships on sites. It is shown that project features and different design preferences have effects on multi-causal and complex nature of the construction accidents[@r11], [@r12]^)^. Researchers have also investigated and analyzed historical data for construction accidents as well as near misses from different countries, to shed light on underlying causes of fatal construction accidents and provide proper information for mitigation and abatement techniques on sites[@r13],[@r14],[@r15],[@r16],[@r17],[@r18],[@r19]^)^. There is also great deal of research that focuses on the specific causes of construction accidents, such as research on heavy equipment activities, related risks and accidents[@r2], [@r20],[@r21],[@r22],[@r23],[@r24],[@r25]^)^. It is striking that an overwhelming portion of fatal construction industry accidents resulted from falls from height, therefore, these accidents have received a great deal of attention for years. Falls from roofs, slips or trips, scaffold safety, protective equipments, modern prevention techniques have been a research field for different practitioners as well as academicians[@r26],[@r27],[@r28],[@r29],[@r30],[@r31],[@r32],[@r33],[@r34],[@r35],[@r36]^)^. Although, accidents due to being struck by or against falling objects and/or equipment generally rank second or third in total accidents, they are usually analyzed in general studies that seek to understand the causes of construction accidents as a whole. However, some research mainly focused on those types of accidents[@r37], [@r38]^)^. Ranking second or third in terms of fatalities, electrocutions are also an important class of accidents in the industry. Research performed to investigate electrical fatalities among construction workers as well as to establish scenarios and flow diagram analysis of the electrical fatalities in the industry[@r39],[@r40],[@r41],[@r42],[@r43],[@r44]). Accident analyses for different work sites with different sizes within the construction industry are crucial for investigating fatalities and establishing a risk assessment models. It is also worth mentioning to cite some recent studies for building, tunneling and highway work zones, because of the fact that they reveal not only characteristics of accidents on those projects but also the causal relationship between the accidents and size of construction sites[@r45],[@r46],[@r47],[@r48],[@r49],[@r50]^)^. In Turkey, both the number of fatalities and the share of total work-site deaths, which the construction industry is responsible for, reflect poor conditions on construction sites. However, research on the causes of construction accidents in Turkey is very limited. Müngen[@r51]^)^ provided the first attempt to classify the construction injuries in the Turkish construction industry. This study resulted in higher number of visits to the Social Insurance Institution (SII) General Directory archives and insurance claim records for construction injuries were separated from other accidents. The analysis of these records has facilitated a better understanding of the nature of safety in the Turkish construction industry. Müngen and Gurcanli[@r52]^)^ and Gurcanli *et al.*[@r25]^)^ analyzed equipment and motor vehicle accidents from the archives of the Social Insurance Institution. Gunay *et al.*[@r53]^)^ analyzed hospital records and evaluated occupational injuries and mortalities from the point of view of forensic medicine. Medical researchers have conducted a retrospective study of industry fatalities by investigating the records of occupational deaths between 1990 and 2001 in the Kocaeli District of Turkey. Fatal occupational injuries in the construction sector were investigated in detail by evaluating the records based on data from 153 deaths[@r54]^)^. Unsar and Sut[@r55]^)^ presented a general assessment of occupational accidents between 2000 and 2005 including the construction industry. In addition, Gurcanli[@r56]^)^ investigated 956 expert witness reports and analyzed third party and child deaths on sites in order to determine the responsible parties for the accidents. Ceylan[@r57]^)^ compares mining, metal and construction industries between the years of 2004 and 2010, by the aid of official statistics. Baradan[@r58]^)^ evaluates the occupational safety and health regulations and standards in Turkey and in developed countries by addressing regulations, related institutions and applied practices. Additionally, Arslan and Kıvrak[@r59]^)^ performed investigations among construction workers to assess the level of safety training and culture and Cecen and Sertyesilisik[@r60]^)^ recommends a practical, economical and functional fall protection system in their study by giving technical details. Unfortunately, published international literature is very limited for occupational accidents in Turkish construction industry, but research have been performing since the beginning of 2013, in other words after the publication of new Occupational Safety and Health Law (No: 6331, 29.12. 2012). A detailed and comprehensive analysis of occupational accidents in Turkish industry has yet to be carried out. This study is designed to fill this hole in the literature, addressing the needs of researchers, academics and safety professionals, not only from Turkey, but any individuals who would like to understand the characteristics and specific risks in the construction industry for employers and related parties. Since the progress in construction safety has only happened very recently and detailed and satisfactory data have not collected for recent years yet, analyses of the historical data become very important also to compare before and after new Occupational Health and Safety Law. This study will be beneficiary for academicians as well as practitioners who will implement new law and related very new regulations on construction sites. Materials and Methods {#s3} ===================== Data collection from the expert witness reports ----------------------------------------------- The source of data is the expert witness reports, which are more reliable and comprehensive than official statistics and records archived in Social Insurance Institution of Turkey (SII). Because SII only stores the cases whose legal procedures are completed and lacks a proper classification or documentation system for the causes of construction accidents. This study analyzes 1,117 expert witness reports submitted to criminal and labour courts collected, accounting for 1,149 fatal and non-fatal injuries. These reports are from all regions of the country covering the years between 1972 and 2008. The time span may seem excessive to derive meaningful conclusions. However, until 2012 (the issue date of new Occupational Safety and Health Law is 20.06.2012, Law Number 6331) construction industry has used the regulations of Health and Safety (in general) issued in 1973 and Construction issued in 1974. Therefore substantial governmental safety policy changes have been observed recently since the government efforts for preparing a new occupational health and safety law began in 2007. Moreover, substantial technical advances regarding occupational safety in construction is very new in Turkey and future studies may compare accident statistics before and after the new Law and related regulations revealed. It should also be noted that, since in insurance claims judicial action and law suit may take many years, in many cases, the authors and their colleagues wrote expert witness reports for incidents that occurred 15 years prior. In the Turkish legislative system, judges of the criminal and labour courts demand expert witness, primarily academics, in most occupational accident cases. In Turkey, when an accident occurs, an investigation is executed by the public prosecutor. If the public prosecutor decides that someone is at fault or that there had been an act of negligence, then documents are sent to criminal court and an official investigation assigns fault in the accident. This final verdict is regularly based on an expert witness report that provides information about responsible parties, technical deficiencies and negligent acts. Labour courts are responsible for the issue of compensation and in those cases the final verdict again is reached with the aid of expert witness reports. Below we discuss the procedures of an expert witness investigation to better understand the data from expert witness reports. The preparation of an expert witness report typically involves an investigation of the premises of the accident and the judicial documents (if they exist) such as statements made by witnesses and defendant, preliminary official record and drawing of the location which the accident occurred, accident report written by employer, statements made by the victim of the
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TAD are luminal breast cancer patients heterozygous for GATA3 mutations within the DBD (exons 5, 6) or TAD (intron 4, 5 or exon 3), respectively. T-test *P*-values of the differences between the DBD and TAD groups are presented at the right bottom corner of each graph. BLBC, basal-like breast cancer; DBD, DNA binding domain; GATA3, GATA binding protein 3; TAD, transactivation domain; WT, wild type. These results demonstrate that distinct breast cancer subtypes are associated with wt/mutGATA3 populations within luminal breast cancer patients, and may suggest that these patients share some of the GATA3-dependent mechanisms of BLBC patients, who are a clinical group with regard to considerations of mode of treatment. Discussion {#Sec22} ========== Breast cancer is, in fact, a collection of alterations in genomic, genetic and expression profiles, leading to a group of breast diseases \[[@CR70]\]. The heterogeneity of the disease(s) creates a challenge in identifying an exclusive driving force and, consequently, early diagnosis, decision on mode of treatment and prognosis \[[@CR71]\]. Clinically implemented signatures today use different biomarkers, such as combined expression and genomic variation differences, to classify patients in clinical groups as a means of decision on mode of treatment. The unique ability of GATA3 as a sole biomarker, that is, not as a part of a genomic signature, to classify breast cancer patients in clinical groups is, thus, uncommon in the context of breast cancer, and suggests that GATA3 is a major force behind processes standing at the core of the disease. While much attention has been given to tumor suppressor functions of GATA3 \[[@CR4]\],\[[@CR12]\],\[[@CR13]\],\[[@CR39]\],\[[@CR72]\],\[[@CR73]\], lately it was reported to mediate ER binding to the genome, thus supporting growth of hormone-driven cancers \[[@CR1]\],\[[@CR20]\]. Our findings connect these different functions by suggesting a cellular-context dependent equilibrium between tumor suppressor and tumor promoting effects. Based on altered regulatory activity of GATA3 upon tumorigenesis, we can postulate that in normal cells GATA3 is associated with tumor suppression activities (for example, differentiation, proper apoptotic processes, reduced proliferation). Conversely, in luminal breast cancer, GATA3 supports aspects of cancer progression through altered signal transduction of hormones and growth factors; increased proliferation and decreased apoptosis; and simultaneously, signaling prognosis associated with GATA3 expression \[[@CR7]\],\[[@CR74]\] may be a result of other processes, including upregulation of genes regulating chromosome integrity (BEGAIN, CEP70, HFM1). Within the host of GATA3 target genes we uncovered, a signature of three genes (*BCL2*, *DACH1* and *THSD4*) separates patients into ER groups, underlining deregulation of apoptotic signaling (negatively regulated by *BCL2* and *DACH1*), ER signaling and cell cycle control (regulated by *DACH1* \[[@CR38]\]-\[[@CR40]\],\[[@CR42]\],\[[@CR43]\]) as possible major processes early in luminal breast cancer development. The function of *THSD4*, currently unknown, may expose additional pathways involved in luminal breast cancer progression. In BLBC, other GATA3-controlled cellular pathways, or lack of downstream ER signaling, may compensate for upregulation of BCL2, THSD4 and DACH1 by GATA3, resulting in a tumor suppressor function. Thus, a model for a GATA3-dependent mechanism controlling transformation involves initial alterations in the milieu of transcription factors expressed in a cell, followed by loss of control on cell cycle progression, apoptosis and ER signaling resulting from deregulation of BCL2, DACH1 and/or THSD4 by GATA3. These changes, in turn, permit further acquisition of tumorigenic-associated signals leading eventually to cancer. This model suggests that GATA3 activity precedes, or, alternatively, circumvents the need for ER signaling in early tumorigenesis, in agreement with supportive evidence \[[@CR1]\], thus placing GATA3 at the core of luminal breast cancer. The effect of GATA3 results, however, not only from direct transactivation of targets. GATA proteins have an established function in locus control regions, directing tissue- and developmental-specific expression patterns of distal regions \[[@CR75]\],\[[@CR76]\]. Indeed, GATA3 binding sites as identified by ChIP-seq are predominantly enriched in intergenic regions. Accordingly, an altered binding pattern in cancer cells would influence the cell's transcription program through chromatin organization, and sequentially transcription, of extensive and distal genomic regions. The dual activities of GATA3 are exemplified by its effect on normal/cancer stem cell populations. In normal cells, GATA3 expression reduced the population of progenitor cells, in agreement with a role in differentiation of these cells into mature luminal cells \[[@CR4]\],\[[@CR66]\],\[[@CR72]\]. Conversely, in luminal cancer cells, GATA3 expression led to proliferation of TICs. Since, in luminal breast cancer models, GATA3 induces differentiation \[[@CR12]\],\[[@CR66]\], we postulate that our observations reflect proliferation of an existing TIC population rather than active de-differentiation. This is consistent with findings in a mouse model, which showed that exogenous expression of GATA3 leads to larger, but more differentiated, tumors, relative to control tumors \[[@CR12]\]. Thus, GATA3 acts to prevent tumorigenesis in normal cells by reducing populations of transformation susceptible progenitor cells, while in luminal breast cancer it induces both differentiation, and, as a tumor-supporting factor, proliferation of therapy-resistant \[[@CR77]\], EMT-associated \[[@CR78]\], TICs. Further functional tests will be needed to fully characterize the equilibrium between tumor supporting- and suppressing-functions of GATA3. GATA3 is one of the frequently mutated genes in breast cancer \[[@CR21]\],\[[@CR22]\],\[[@CR79]\], predominantly in the luminal subtype \[[@CR79]\]. Distinct GATA3 regions necessary for chromatin remodeling and direct transactivation \[[@CR80]\] predict that mutations of different domains may affect different sets of genes. Accordingly, mutations and expression analyses demonstrated distinct molecular signatures associated with mutations of specific functional domains. Clustering of patients bearing TAD mutations with BLBC patients may result from reduced activity on target genes \[[@CR81]\] mimicking the phenotype of GATA3-low breast cancer, while an altogether divergent and discrete signature characterizes patients with DBD mutations. Further experiments are needed to fully characterize the molecular basis and possible clinical outcome associated with the different mutations. However, these molecular signatures suggest that molecular typing and, subsequently, prognosis and treatment considerations for breast cancer patients may require incorporation of specific GATA3 mutations. Conclusions {#Sec23} =========== In summary, a critical role is demonstrated for GATA3 within the networks that govern breast cancer progression. Changes in genomic targets and regulatory activity may control tumor-associated mechanisms. Considerations of mutational modifications demonstrate how a GATA3 positive cancer may actually produce a distinct clinical phenotype. Our findings combine to expose possible molecular mechanisms associated with breast cancer progression and suggest that typing of patients according to their GATA3 behavior may add a layer in therapeutic considerations. Additional files {#Sec24} ================ Electronic supplementary material ================================= {#Sec25} Additional file 1: Table S2.: Primers used in real time PCR. (DOC 40 KB) Additional file 2: Table S1.: T-test *P*-values for genes dividing breast cancer patients groups by ER status at the highest statistical significance. (DOC 31 KB) Additional file 3: Figure S1.: GATA3 induces Bcl2, DACH1 and THSD4 in luminal breast cancer lines. Relative expression levels of specified genes were measured 48 hours following siRNA transfections relative to Ctrl siRNA transfected cells, both normalized to beta-actin. Results of three pooled GATA3 siRNAs are shown. (PDF 102 KB) Additional file 4: Figure S2.: Silencing of GATA3 is followed by downregulation of tested genes in luminal breast cancer cells. Three pooled siRNA were used to silence GATA3 in MCF7 or T47D lines (a). Relative expression levels of tested genes were measured in MCF7 (b) and T47D (c) cells transfected with GATA3 siRNA relative to control transfected cells, both normalized to beta-actin. Results are average ± standard error of three to five independent experiments. \*T-Test *P*-values \<0.1; \*\*T-Test *P*-values \<0.05; \*\*\*T-Test *P*-values \<0.01. (PDF 272 KB) Below are the links to the authors' original submitted files for images.Authors' original file for figure 1Authors' original file for figure 2Authors' original file for figure 3Authors' original file for figure 4Authors' original file for figure 5Authors' original file for figure 6Authors' original file for figure 7 BLBC : basal-like breast cancer ChIP : chromatin immunoprecipitation DBD : DNA binding domain EMT : epithelial mesenchymal transition ER : estrogen receptor GATA3 : GATA binding protein 3 GFP : green fluorescent protein GO : gene ontology hMEC : human mammary epithelial cells siRNA : small interfering RNA TAD : trans-activation domain TIC : tumor initiating cells **Electronic supplementary material** The online version of this article (doi:10.1186/s13058-
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for many years as a sales and marketing organization representing several small cruise lines. It now charters and operates three ships owned by other companies. The firm, some of whose owners originally worked for long-defunct CTC Cruises, specializes in adults-only (16 and over) cruises from regional UK ports, and provides traditional cruise features such as mid-morning bouillon, and captain's welcome and farewell dinners. The onboard product, particularly the food, is at the lower end of the market, including ships operated for ex-UK cruises. Gratuities are not included in the cruise fare. **Crystal Cruises** Crystal Cruises was founded in 1988 by Nippon Yusen Kaisha (NYK), the world's largest cargo ship and transportation company, with a fleet of more than 700 ships. The American-managed company is based in Miami. _Crystal Harmony_ , the company's first ship, was built in Japan, and debuted in New York in May 1990 to great acclaim. Meanwhile, Crystal Cruises introduced two new ships, _Crystal Symphony_ in 1995, and _Crystal Serenity_ in 2000, the first built in Finland, the second in France. In 2006 _Crystal Harmony_ was transferred to parent company NYK as _Asuka II_ for its Asuka Cruise division, for Japanese speakers. The ships operate worldwide itineraries with flair. Both ships are superbly maintained, and passengers who seek fine food and excellent service in a sophisticated setting should be delighted with their choice of ship and company. There is even an excellent Nobu sushi/sashimi bar aboard _Crystal Serenity._ Open-seating dining was introduced in January 2011 for the first time, but passengers can still opt for fixed-time dining. In spring 2012 Crystal Cruises adopted all-inclusive pricing, with drinks, wines, and gratuities included. In 2015 the company was acquired by Genting Hong Kong (owner of Genting Cruise Lines, the parent company of Dream Cruises and Star Cruises and a minor shareholder of Norwegian Cruise Line Holdings Ltd). It introduced Crystal Yacht Cruises (rebranded in 2016 as Crystal Yacht Expedition Cruises) with the introduction of the refurbished _Crystal Esprit._ The company's ambitious expansion plans have since been scaled back somewhat, but there are still three 'Executiveclass' ships due for introduction in 2022, plus an expedition-style ship (Crystal Endeavor), scheduled to debut in 2020. **Cunard** Cunard was established in 1839, as the British and North American Royal Mail Steam Packet Company, to carry the Royal Mail and passengers from the Old World to the New. Its first ship, _Britannia_ , sailed on its maiden voyage on American Independence Day in 1840. The author Charles Dickens crossed the Atlantic aboard the ship in 1842 together with 62 other passengers, 93 crew members, one cow, and, most important, Her Majesty's mails and dispatches. Since 1840, Cunard has always had ships built to sail across the North Atlantic. From 1850 until the arrival of _QE2_ in 1969, all of the line's ships and those of White Star Line (with which Cunard merged in 1934) had several classes. Your luggage label, therefore, declared not only your name but also what you could afford. Today, there's no class distinction, other than by accommodation grade. _Crystal Serenity_ docked in Malta. Crystal Yacht Cruises _Queen Elizabeth_ and _Queen Mary 2_ rendezvous in Sydney. Cunard Line Cunard celebrated its 175th anniversary in 2015. One is still reminded of the company's illustrious history. For example, Cunard was the first company to take passengers on regularly scheduled transatlantic crossings. It introduced the first passenger ship to be lit by electricity ( _Servia_ , 1881) and the first steam turbine engines in an ocean liner ( _Carmania_ , 1905. The line was the first to have an indoor swimming pool aboard a ship ( _Aquitania_ , 1914), and it pioneered the around-the-world cruise ( _Laconia_ , 1922). Cunard long held the record for the largest passenger ship ever built _(Queen Elizabeth_ , between 1940 and 1996). The ships incorporate a lot of maritime history and the grand traditions of ocean liners – as opposed to the other ships, with their tendency toward tacky high-street trappings. Cunard is also the _only_ cruise line that lets you take your dog or cat with you _(Queen Mary 2_ transatlantic crossings only). While Samuel Cunard was from Halifax, Nova Scotia, he established the company in Liverpool. Today, the company is owned by the American Carnival Corporation. The three _Queens_ were built in France and Italy, registered in Hamilton, Bermuda, with a home port of Southampton, England. The onboard currency is the US dollar. Cunard has four distinct accommodation grades, each linked to a specific restaurant: Queens Grill, Princess Grill, Britannia Club, and Britannia. **Cunard** has one real ocean liner _(Queen Mary 2)._ It provides a regular transatlantic crossing service from April to December, while the company's two other two ships are more about regular cruising, albeit in ocean-liner style. All three (a fourth is scheduled to debut in 2022) are best suited to a wide range of seasoned and well-traveled couples and solo travelers who enjoy the cosmopolitan setting of an ocean liner. Dressing more formally for dinner is encouraged, although – with the exception of the grill rooms – the cuisine is largely of mass-market quality, with many traditional British and French dishes. **Disney Cruise Line** It was Lawrence (Larry) P. Murphy, executive vice-president of the Walt Disney Company, who was the guiding light in the early 1990s behind the expansion of the company into the cruise business. Previously, Disney had flirted with cruising by participating in a licensing agreement with a Florida-based cruise line, the now-defunct Premier Cruise Lines, with three vintage ships based in Port Canaveral. Murphy and other Disney executives explored the possibility of creating their own ships when the licensing agreement ran out. They concluded that pairing with an established cruise line wouldn't work because of Disney's policy of generous spending on the guest experience. Disney takes its brand to Alaska. Disney Cruise Line The solution: create a new cruise line, wholly owned and controlled by Disney, and to be known as Disney Cruise Line. The company committed an astonishing $1 billion to the project. Its two mid-size ships, _Disney Magic_ (1998) and _Disney Wonder_ (1999), the first cruise ships since the 1950s to be built with two funnels, cater to loyal Disney followers, and everything aboard the ships is Disney – every song, every piece of artwork, every movie and production show – and Mickey's ears adorn the ships' funnels. There's no casino and no library. However, its 'rotation dining' concept proved to be completely Disneylogical; you move, together with your waiter, to each of three identically sized restaurants – each with different decor – in turn. One new, larger ship, _Disney Dream_ , joined the fleet in 2011, and sister ship _Disney Fantasy_ arrived in 2012. Disney, of course, is all about families with children, and the ships cater to both. You can buy a package combining a short stay at a Disney resort and a cruise. Gratuities are not included in the cruise fare. Disney has its own cruise terminal at Port Canaveral, Florida, its design being an imaginative but close copy of the Ocean Terminal in Southampton, UK, frequented by yesteryear's ocean liners but little used today. The terminal and pier were extended in 2010 and connected to a new parking garage. Two new (slightly larger) ships are on order for delivery in 2022 and 2023. **Dream Cruises** Owned by Genting Cruise Lines, this brand is a sister company to Star Cruises. Dream Cruises has two ships. The stunning _Genting Dream_ started sailing in November 2016, and she was joined by sister ship _World Dream_ in 2017. The company is a much more upscale and advanced version of Star Cruises, and it is aimed specifically at the Asian (and particularly, the mainland Chinese) market, with an abundance of bright decor and upbeat, colorful razzle-dazzle shows. For part of the year, the assigned ship offers embarkation in three different countries, including its home port of Hong Kong, Two new 204,000-ton large resort ships are scheduled to debut in 2020 and 2021. **Fred. Olsen Cruise Lines** This Norwegian family-owned and family-run company was founded in Hvitsten, a town on Oslofjord, Norway, in 1848. Today, a fifth-generation Olsen, Anette, owns and runs the company from its headquarters in Suffolk, England. The group also has interests in hotels, aviation, shipbuilding, ferries, and offshore industries. The company specializes in cruises for adults, who are usually retired and of senior years – typically over 65. Aboard the ships, interior design reflects traditional design features, and dressing for dinner is expected on four nights during a two-week cruise. Many theme cruises, such as gardening and horticulture
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YellowRibbonPage } from './index'; describe('Find Yellow Ribbon Page <FindYellowRibbonPage>', () => { it('renders what we expect', () => { const tree = shallow(<FindYellowRibbonPage />); const text = tree.text(); // Expect there to be: expect(text).to.include('Find a Yellow Ribbon school'); expect(text).to.include( 'Find out if your school participates in the Yellow Ribbon Program.', ); expect(text).to.include( 'Search for schools participating in the current academic year, ', ); tree.unmount(); }); }); The Revival of the Leveraged Buyout Fund, Strategic and Tactical Implications For Portfolios Mega funds are no longer the only place for LBOs, the middle market is packing a significant punch for investors. By: Bailey McCann Few vehicles in private equity carry with them as much folklore as leveraged buyout (LBO) funds. Popularized during Wall Street's go-go years in the 1980s, the leveraged buyout calls to mind visions of Gordon Gekko like bankers and East End Avenue addresses. Before the crash, some LBO funds amassed significant assets and deal track records, effectively becoming 'mega' funds, leading to some of the biggest deals in the industry. However, these funds started to decline even before 2008, as issues with leverage, paying too much and going after trophy deals regardless of quality dampened reputations and investor interest. In the small and mid-market, LBO funds have plugged along more steadily, spurred on by consistent activity within that market segment and an arguably more focused approach to deals. That said, like the markets they serve, small to mid-market funds have also seen more failures and a more challenging asset raising environment. For investors looking over these realities, and coming off tough crisis years, they may be left to wonder if the LBO arena is more trouble than it's worth. Research out this month shows that current market conditions may be more favorable for LBOs than they have been for some time. According to credit strategists Hans Mikkelson and Yuriy Shchuchinov at Bank of America Merrill Lynch, market conditions have become "unusually conductive for leveraging transactions for this stage in the typical cycle." This could spell the return of LBO funds, especially in the small to mid-market, according to data in the report. For investors trying to decide how to allocate to an LBO fund, there are a variety of factors to consider - especially given the dramatic changes in both the economic and regulatory environments post 2008. The Mega Fund Isn't Dead Yet As with other industries, size comes with a variety of benefits: name recognition; access to capital and talent to manage it; a track record with deals people know about; and reliability. Taken together, these factors tend to equate to an overall lower risk profile and investor trust resulting from the institutional grade infrastructure these firms offer. In the Bank of America Merrill Lynch report, the authors say that the current low yield environment, coupled with recapitalized banks and liquidity in the public markets could start pushing deal size above $10bn. New regulations require banks to stay below 6x leverage in their transactions, but the continuation of QE3 is likely to start pushing banks to lend, with the only real limitation on deal size being the equity size of the equation. The club deal may be hard to come by, but not impossible. China is on pace for its biggest ever leveraged buyout with four more banks coming on to finance the leveraged buyout of China's Focus Media Holding at $3.7 bn. In the report, strategists also note last year's acquisition of Synthes by Johnson and Johnson, post-deal filings show that at that time three private equity firms came together for a $20bn offer. However, the problem for mega funds or even big club deals, is the ability to create significant value. For deals that are of suitable size, they often involve brands that are organizationally entrenched, "the hardest part about buying a big brand is that the industry is often more mature, the management team has already taken care of the low hanging fruit, and the way the business works is well established. It can be very difficult to make real improvements," explains David Fann, President & CEO of TorreyCove Capital Partners in an interview with Opalesque. TorreyCove Capital Partners, a global alternative investments specialist, currently overseeing approximately $19.5 billion of private equity assets, recently released their own take on the LBO landscape. Fann and his firm advise a variety of public pension plans, and large institutions on private equity investing. Multiples Abound in the Middle Market For investors seeking LBOs that offer a higher multiple, the middle market may be the sweet spot right now. Always competitive, the middle market LBOs typically come with greater returns but also greater risk. The funds are smaller, and according to TorreyCove, working with them requires as much due diligence as the deal itself. For investors seeking greater deal activity, and the opportunity to make real capital improvements, the high-touch relationships that come with these firms are likely to make them more appealing. Middle market firms also tend to have more strategic discipline than their larger counterparts. Many of the mega firms operate under public scrutiny and take more diversified approaches in order to bring in assets on a more consistent basis even if those assets are not directly aligned with all investment interests. "There is always going to be a greater blowup risk with these funds and smaller funds, by definition," Fann notes. "But, there are benefits too - people are hungrier, they work harder. Investors simply have to do their research and keep their eyes open." The relative newness of a given investor's interest in LBOs may also come into play, writing in the article, authors for TorreyCove note that, "the higher dispersion of returns within the small and middle market buyout spaces, combined with the much larger number of managers operating in those spaces, means that institutions desiring substantial exposure in the lower end of the market must possess strong organizational resources and expertise. If these factors are in place, it follows that such organizations would be better served by a substantial bias toward the middle/small portion of the buyout sector." However, if a program is relatively new, it may be better served with a larger, more established fund, trading away some of that multiple for organizational consistency. Fann explains that weighing these issues is especially important for large public institutions given today's return starved environment. "If you look at the next five years, or even if you look retrospectively, private equity has been an outperforming asset class for large institutions, especially pension funds. The only way pension funds can meet that 8% return requirement is to do more investing in alternatives. Private equity is one area where those returns can be achieved and sustained." This article was published in Opalesque's Private Equity Strategies our monthly research update on the global private equity landscape including all sectors and market caps.Team (First-Place Votes) Points 1. Houston (5) 59 2. UConn (3) 50 3. UCF 49 4. ECU 45 5. USF (1) 43 6. Wichita State 29 7. Memphis 19 8. Tulane 18 9. Cincinnati 12 The reigning American Athletic Conference baseball champion, Houston, was tabbed as the 2018 favorite by the league’s nine coaches in the conference’s preseason coaches’ poll.After earning the 2017 American Pitcher of the Year honor, Houston junior southpaw Trey Cumbie was voted the league’s Preseason Pitcher of the Year. Last year’s Rookie Position Player of the Year, Rylan Thomas, of UCF was named Preseason Player of the Year.The American has had 10 NCAA tournament bids over the last three years with UCF, Houston and USF making the trip last season. For the second time in three years, the Cougars were chosen as one of 16 teams to host an NCAA regional last season. UCF shared the 2017 regular season title with Houston., which received five first-place votes and 59 points in the preseason poll, posted the most wins in the league with a 42-21 record and 15-9 conference mark last season, falling to Texas A&M 4-3 in the final game of the NCAA Houston Regional. The 40-win season was the fourth under head coach Todd Whitting. The NCAA Regional appearance was the program’s 21st. Cumbie led the conference with a 2.04 ERA, four complete games, two shutouts and a 10-2 record through 101.1 innings pitches. The All-America lefty fanned 82 batters in 2017. At the plate, Houston led the conference with a .464 slugging percentage 169 runs, 11 triples, 150 RBIs and 31 homers.was picked second in the preseason poll with 50 points and three first-place votes. The Huskies had three players represented on preseason all-conference list after going 33-25 and 14-10 in conference play last season. The Huskies’ 2017 campaign came to an end with a loss to Houston in the American Athletic Conference Championship semifinals. UConn junior left-handed pitcher Tim Cate and junior catcher Zac Susi were unanimous selections on the preseason all-conference team. Sophomore shortstop Anthony Prato batted .303 last year with 33 RBIs and 10 doubles
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$ $84.6$ BiDAF Single - $41.7$ $80.9$ $83.4$ $84.8$ BiDAF Ensemble - - $79.9$ $82.0$ $83.2$ ----------------------------------- ------------ ------------ ----------- ------------ -------------- [ ]{} **BERT-Large** **XLNet-Large** **RoBERTa-Large** ------------------------------- ---------------- ----------------- ------------------- Original (for reference only) $82.5\%$ $85.2\%$ $85.8\%$ *Swap* Noise $33.8\%$ $43.0\%$ $46.1\%$ *Middle Random* Noise $28.6\%$ $31.9\%$ $32.2\%$ *Fully Random* Noise $5.5\%$ $4.4\%$ $3.3\%$ *Keyboard Typo* Noise $23.1\%$ $27.2\%$ $30.4\%$ *Natural* Noise $47.7\%$ $57.4\%$ $54.9\%$ Appendix B: Attention-level Results of NLI Task {#appendix-b-attention-level-results-of-nli-task .unnumbered} =============================================== ### Antonymy Evaluation {#antonymy-evaluation .unnumbered} For this analysis, we took a representative adversarial example where a word in the sentence was replaced by its *antonym*. The model is asked to decide if there is a contradiction, neutral, or entailment relationship between them. We expect the model to connect the attention between the replaced words to predict the correct answer. Assume the following pair of sentences: [I saw that daylight was coming, and heard the people ]{}`sleeping` [ ]{}[up.]{}\ [I saw that daylight was coming, and heard the people ]{}`waking` [ ]{}[up.]{}\ In this representative example for testing antonyms, we computed the attentions produced by XLNet, RoBERTa, and BERT. We checked the layers and heads where a clear attention pattern was present between the word and its antonym, as shown in Figures \[XLNet\_antonym\] - \[BERT\_antonym\]. Within this particular case, for XLNet, we saw that only 2.86% of the total attention heads and layers had this pattern. For RoBERTa, this number was 2.60%, and for BERT 1.56%. On the other hand, for all models, most of the attention was paid to separators and all words from the reference sentence without distinction (Figure \[failed\_antonym\]). ### Numerical Reasoning Evaluation {#numerical-reasoning-evaluation .unnumbered} For samples of *numerical reasoning* for NLI, the expectation is that the model should pay attention to words like *“more”* or *“less”* to check if there is a change in numerical references. Assume the following pair of sentences: [The next day Bob took the test and with this grade, included the new average, ]{}`was more than 48.`\ [The next day Bob took the test and with this grade, included the new average, ]{}`was 78.`\ Nevertheless, for this testing example, the *premise* includes *“more than 48”* and the *hypothesis* replaces this last part by *“78”*, but all the models (XLNet, RoBERTa and BERT) incorrectly predicted *“contradiction”*. We observed that the expected pattern (shown in Figures \[XLNet\_numerical\]- \[BERT\_numerical\]) is a very infrequent pattern for all models (for XLNet it appeared in 5.20% of the cases, for RoBERTa in only 4.42% and for BERT this percentage was 1.30%). For other cases, they focused on sentence separators (as shown in Fig \[numerical\_failed\]). Appendix C: Attention-level Results of QA Task {#appendix-c-attention-level-results-of-qa-task .unnumbered} ============================================== ### QA task attention-level evaluation {#qa-task-attention-level-evaluation .unnumbered} For the QA task, we manually inspected failure cases to see the amount of attention the model paid to the introduced adversaries versus to the correct answer. Here we show one representative example of a *”what"* question: `Question: What company took over Edison Machine works?`.\ `Answer: General Electric`.\ `Adversary: Stark Industries`.\ In this particular example, with the question *“What company took over Edison Machine works?”*, the correct answer was *“General Electric”*, and the artificially introduced adversary was *“Stark Industries”*, appended at the end of the context of the original sample. All models fell into the same trap. It can be seen in Figures \[XLNet\_SQUAD\]- \[BERT\_SQUAD\] that they paid attention to the wrong answer. In this case, this pattern appeared in 52% of the layer-heads of XLNet, 60% in the case of RoBERTa, and 30% on BERT. Nevertheless, while checking the level of certainty of each model in the predicted wrong answer for this example, XLNet had a 43.3% certainty probability, 75.5 % BERT, and the most mistaken was RoBERTa with a 99.9% certainty probability for predicting the wrong answer (which is consistent with the sharpness of attention in Figure \[RoBERTa\_SQUAD\]). This behavior provides evidence that the three models behave slightly different and that increased accuracy in the main task (before adversarial evaluation) is no direct indicator of increased robustness in all cases, but only in the average case. [^1]: we released the dataset at <https://github.com/caspillaga/noisy-squad> [^2]: We use the sets provided by the authors to avoid discrepancy during the procedure. [abhilasharavichander.github.io/NLI\_StressTest](abhilasharavichander.github.io/NLI_StressTest) [^3]: The majority class is used as a baseline of random guessing. Effective Immediately - - No Stick Bow Label Required Until 1/1/10 This just in...the NFHS has decided to delay the implementation of Field Hockey rule 1-6-4 until January 1, 2010 which requires a permanent label with the bow measurement on every field hockey stick. Click on the link inside of the story for the official NFHS memo regarding this change.Public Funds Account for Over 70 Percent of Health Care Spending in California. In California, personal health care expenditures are estimated to total more than $367 billion in 2016. Approximately 71 percent of these expenditures will be paid for with public funds (i.e., taxpayer dollars). This estimated contribution of public funds to health care expenditures is much higher than estimates that include only major health insurance programs such as Medicare and Medicaid. Several additional public funding sources also contribute to health care expenditures in the state, including government spending for public employee health benefits, tax subsidies for employer-sponsored insurance and the Affordable Care Act (ACA) insurance exchange, and county health care expenditures. As health care reform continues to take effect, it will be important to monitor the public versus private contributions to state health care expenditures to ensure that funds are being distributed both efficiently and equitably.Tag Archives: mr vegas Legendary U.K. based reggae label, Greensleeves Records will celebrate its 40th anniversary with new and commemorative product releases and multiple events in London, Paris and New York throughout Spring and Summer 2017. The festivities will commence in April for Record Store Day and continue through September capping at the Notting… Continue reading The artiste made the announcement on social media over the weekend. “Thanks to the fans that stood by me over the years,” Mr Vegas said, adding “This is the start of a new journey. This is the day that I answered to his call. I have decided to make Jesus… Continue reading Dancehall star Mr Vegas has, over the years, paid tribute to his homeland with a number of recordings, including ‘Sweet Jamaica’ and ‘Gi Wi Back Wi Sweet Jamaica’. Vegas recently recorded and released a hot new track titled Go Before Dem to show his support for the Jamaican athletes participating… Continue reading Levy was born in Clarendon, Jamaica. He formed a band called the Mighty Multitude, with his cousin, Everton Dacres; the pair released “My Black Girl” in 1977. Levy established his solo career the next year with “A Long Time Since We Don’t Have No Love”; though the single was a… Continue reading Mr. Vegas delights fans with his latest track “Identify My Love“, released on iTunes on February 26, 2016. “Identify My Love” is the sound of original authentic dancehall, mixed with the melodious vocals and catchy lyrics from Mr. Vegas. “Identify My Love” is one of many new tracks Mr. Vegas… Continue reading NY: Veteran dancehall DJ Tiger, who over the Labor Day weekend made his first outdoor festival appearance in NY since he was seriously injured in a motorcycle accident 22 years ago, proved that a cat does indeed have
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A Source Book of Philippine History To Supply a Fairer View of Filipino Participation and Supplement the Defective Spanish Accounts PHILIPPINE PROGRESS PRIOR TO 1898 By AUSTIN CRAIG and CONRADO BENITEZ Of the College of Liberal Arts Faculty of the University of the Philippines Philippine Education Co., Inc., Manila, 1916 The following 720 pages are divided into two volumes, each of which, for the convenience of the reader, is paged separately and has its index, or table of contents: VOLUME I I. The Old Philippines' Industrial Development (Chapters of an Economic History) I.--Agriculture and Landholding at the time of the Discovery and Conquest. II.--Industries at the Time of Discovery and Conquest. III.--Trade and Commerce at the Time of Discovery and Conquest. IV.--Trade and Commerce; the Period of Restriction. V.--The XIX Century and Economic Development. By Professor Conrado Benitez II. The Filipinos' Part in the Philippines' Past (Pre-Spanish Philippine History A. D. 43-1565; Beginnings of Philippine Nationalism.) By Professor Austin Craig VOLUME II III. The Former Philippines thru Foreign Eyes (Jagor's Travels in the Philippines; Comyn's State of the Philippines in 1810; Wilkes' Manila and Sulu in 1842; White's Manila in 1819; Virchow's Peopling of the Philippines; 1778 and 1878; English Views of the People and Prospects of the Philippines; and Karuth's Filipino Merchants of the Early 1890s) Edited by Professor Craig Made in Manila--Press of E. C. McCullough & Co.--The Work of Filipinos EDITOR'S EXPLANATIONS AND ACKNOWLEDGMENTS This work is pre-requisite to the needed re-writing of Philippine history as the story of its people. The present treatment, as a chapter of Spanish history, has been so long accepted that deviation from the standard story without first furnishing proof would demoralize students and might create the impression that a change of government justified re-stating the facts of the past in the way which would pander to its pride. With foreigners' writing, the extracts herein have been extensive, even to the inclusion of somewhat irrelevant matter to save any suspicion that the context might modify the quotation's meaning. The choice of matter has been to supplement what is now available in English, and, wherever possible, reference data have taken the place of quotation, even at the risk of giving a skeletony effect. Another rule has been to give no personal opinion, where a quotation within reasonable limits could be found to convey the same idea, and, where given, it is because an explanation is considered essential. A conjunction of circumstances fortunate for us made possible this publication. Last August the Bureau of Education were feeling disappointment over the revised school history which had failed to realize their requirements; the Department of History, Economics and Sociology of the University were regretting their inability to make their typewritten material available for all their students; and Commissioner Quezon came back from Washington vigorously protesting against continuing in the public schools a Philippine history text which took no account of what American scholarship has done to supplement Spain's stereotyped story. Thus there were three problems but the same solution served for all. Commissioner Rafael Palma, after investigation, championed furnishing a copy of such a book as the present work is and Chairman Leuterio of the Assembly Committee on Public Instruction lent his support. With the assistance of Governor-General Harrison and Speaker Osmena, and the endorsement of Secretary Martin of the Department of Public Instruction, the Bureau of Education obtained the necessary item in their section of the general appropriation act. Possibly no one deserves any credit for conforming to plain duty, but after listing all these high officials, it may not be out of place to mention that neither has there come from any one of them, nor from any one else for that matter, any suggestion of what should be said or left unsaid or how it should be said, nor has any one asked to see, or seen, any of our manuscript till after its publication. Insular Purchasing Agent Magee, who had been, till his promotion, Acting Director of the Bureau of Education, Director Crone, returned from the San Francisco Exposition, and Acting Auditor Dexter united to smoothe the way for rapid work so the order placed in January is being filled in less than three months. Three others whose endorsements have materially assisted in the accomplishment of the work are President Villamor of our University, Director Francisco Benitez of its School of Education, and Director J. A. Robertson of the Philippine Library. And in recalling the twelve years of study here which has shown the importance of these notes there come to mind the names of those to whom I have been accustomed to go for suggestion and advice: Mariano Ponce, of the Assembly Library, Manuel Artigas, of the Filipiniana Section of the Philippines Library, Manuel Iriarte of the Executive Bureau Archives, Dr. T. H. Pardo de Tavera and Epifanio de los Santos, associates in the Philippine Academy, Leon and Fernando Guerrero, Jaime C. De Veyra, Valentin Ventura, of Barcelona, J. M. Ramirez, of Paris, the late Rafael del Pan, Jose Basa, of Hongkong, and Doctor Regidor, of London, all Filipinos, Doctor N. M. Saleeby, H. Otley Beyer, Dr. David P. Barrows, now of the University of California, along with assistance from the late Professor Ferdinand Blumentritt, of Leitmeritz, Dr. C. M. Heller, of Dresden, and the authorities of the British Museum, Congressional Library, America Institute of Berlin, University of California Library, and the Hongkong and Shanghai public libraries and Royal Asiatic Society branches. It is due the printer, Mr. Frederic H. Stevens, manager of E. C. McCullough & Co.'s press; Mr. John Howe who figured out a sufficient and satisfactory paper supply despite the war-time scarcity; and Superintendent Noronha, that after the first vigorous protests against departures from established printing-house usages, they loyally co-operated in producing a book whose chief consideration has been the reader's use. Paper, ink, special press-work and the clear-cut face chosen for the hand-set type have combined to get a great deal more matter into the same space without sacrifice of legibility; putting minor headings in the margin has been another space-saver
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Michelle Corbitt; Powerline, Inc., a Colorado Corporation; and VIP Global Designs, Inc., A Colorado Corporation, Respondents. No. 33528. Supreme Court of Nevada. April 13, 2001. *12 Law Offices of John & Elizabeth Foley, Las Vegas, for Appellant. Alverson, Taylor, Mortensen, Nelson & Sanders and Nathan R. Reinmiller, Las Vegas, for Respondents Powerline, Inc., and VIP Global Designs, Inc. Hannah C. Irsfeld and Bradley L. Booke, Las Vegas, for Respondents Jeff and Michelle Corbitt. Before MAUPIN, C.J., ROSE and BECKER, JJ. OPINION PER CURIAM. This appeal arises from a judgment entered in a negligence action brought by respondents Jeff and Michelle Corbitt against appellant GES, Inc. ("GES"),[1] and respondents Powerline, Inc., and VIP Global Designs, Inc. ("Powerline/VIP").[2] GES appeals, claiming that it enjoys immunity from the Corbitts' suit under the Nevada Industrial Insurance Act ("NIIA"). GES also claims that the district court erred in finding it jointly and severally liable with Powerline/VIP. While we conclude that GES is not immune from suit under the NIIA because its normal work was not the same as Mr. Corbitt's, we agree that the district court erred in finding it jointly and severally liable. Accordingly, we affirm the district court's judgment in part and reverse it in part. FACTS The accident in question occurred during preparation of an exhibit booth at the 1995 Winter Consumers Electronic Show ("the convention") in Las Vegas. Mr. Corbitt was employed as a lighting technician by Legends in Concert ("Legends"), an entertainment group scheduled to perform during the convention at the Powerline/VIP exhibit site. Mr. Corbitt was severely injured while supervising the placement and programming of lighting at the exhibit booth. As background, GES, a licensed Nevada electrical contractor and provider of drayage services for Las Vegas convention events, contracted to assemble a ground truss structure at the Powerline/VIP booth on which cyberlighting for the Legends performance was to be installed. This truss structure was the focal point of the accident. GES employees placed the truss assembly over the booth and temporarily secured the apparatus with nylon straps. According to evidence adduced at trial, GES employees advised Powerline/VIP representatives that the truss assembly had not been finally secured. The record also reveals that GES employees understood the nylon straps to be temporary and that Bart Delorenzo, vice-president of marketing for VIP, would purchase the appropriate bolts or clamps to stabilize the truss. Unfortunately, however, the cyberlight installation proceeded under the supervision of Powerline/VIP employees before the truss was secured. *13 An instant after the second cyberlight was hung, the truss swayed and collapsed in Mr. Corbitt's direction, knocking him from a forklift on which he was standing. Mr. Corbitt fell face first approximately thirteen feet to the parking lot surface and suffered a fractured skull, fractured sinuses, fractured wrists and elbow, and other related injuries. The Corbitts initiated a negligence action against GES, Powerline/VIP, and a third defendant, Skytop Total Production Services ("Skytop"). The district court denied GES's motion for summary judgment, which was based upon its claim of immunity under the NIIA. At trial, the jury returned a general defense verdict in favor of Skytop, but awarded damages exceeding $1,100,000.00 against Powerline/VIP and GES. The jury, by way of special verdict, assessed the comparative fault of the parties as follows: ten percent against Mr. Corbitt, twenty-five percent against GES, and sixty-five percent against Powerline/VIP. In response to a motion to clarify the verdict, the district court found that Powerline/VIP and GES acted in concert and, thus, concluded that these defendant parties were jointly and severally liable to the Corbitts.[3] Thereafter, Powerline/VIP entered into a settlement with the Corbitts that was approved by the district court as having been undertaken in good faith.[4] DISCUSSION NIIA immunity GES argues that it is immune from liability under the NIIA and that the district court erred in refusing to grant it summary judgment. An order denying summary judgment is not independently appealable;[5] however, we may review the propriety of the district court's summary judgment ruling because GES has properly raised the issue in its appeal from the final judgment.[6] Our review is de novo and without deference to the district court's findings.[7] Summary judgment is appropriate only when there are no material issues of fact and the moving party is entitled to judgment as a matter of law.[8] Under the NIIA, workers' compensation is an employee's only remedy against his employer and co-employees for an industrial injury; however, the injured worker may pursue a common law tort action against any tortfeasor who is not his statutory employer or co-employee.[9] To determine whether GES and Corbitt had a statutory employment relationship under the NIIA, so that GES is immune from the Corbitts' negligence suit, we apply the "normal work test" originally articulated in Meers v. Haughton Elevator[10] and now codified as NRS 616B.603(1)(b).[11] The "normal work test" is used in non-construction cases and in construction cases when the defendant is not a principal contractor[12] licensed under NRS chapter 624 or is not working pursuant to a construction agreement with such a licensed principal contractor.[13] Here, the exhibit *14 booth and the lighting truss structure were displays, requiring assembly, not construction. In addition, although GES was licensed under NRS chapter 624, GES was not a principal contractor and GES's work at the Powerline/VIP booth was not performed pursuant to a construction agreement with a licensed principal contractor or within the scope of its specialty contractor's license. Under the "normal work test," GES is immune from suit under the NIIA only if it was in the same trade, business, profession or occupation as Legends, Mr. Corbitt's employer.[14] According to the record before us, GES and Legends were in different trades entirely, with GES supplying electricity, hauling and assembly services to convention exhibitors, and Legends providing live stage entertainment involving music and custom lighting for exhibitors. Mr. Corbitt worked for Legends as a lighting designer and programmer. Thus, because GES was not entitled to NIIA immunity under the normal work test analysis, the district court did not err by denying GES's motion for summary judgment. Joint and several liability GES argues that the district court erred in finding it jointly and severally liable with Powerline/VIP under NRS 41.141(5)(d), which permits such liability for defendants who act in concert. We agree. NRS 41.141 was amended in 1987 to read, in relevant part: 4. Where recovery is allowed against more than one defendant in such an action [where comparative negligence is a viable partial defense],[15] except as otherwise provided in subsection 5, each defendant is severally liable to the plaintiff only for that portion of the judgment which represents the percentage of negligence attributable to him. 5. This section does not affect the joint and several liability, if any, of the defendants in an action based upon: ... (d) The concerted acts of the defendants.... In a tort action, when the plaintiff is found comparatively negligent in an apportioned amount of fifty percent or less, defendants found liable are presumed under NRS 41.141(4) to be severally liable unless an exception under subsection (5) applies. Here, the jury, by special verdict, apportioned liability in the following percentages: Mr. Corbitt ten percent; GES twenty-five percent; Powerline/VIP sixty-five percent. Although Mr. Corbitt's comparative negligence presumptively rendered GES severally liable on the negligence claim, the district court subsequently entered judgment imposing joint and several liability on GES and Powerline/VIP based upon the concerted acts exception in NRS 41.141(5)(d). Specifically, the district court found that Powerline and GES's negligence combined to cause the injury to [Mr. Corbitt]. GES and Powerline worked together to get the truss/exhibit put up. Both defendants were negligent in constructing the truss. Although GES's employees told Powerline that the straps would not secure the corners [of] the truss, GES is not relieved of liability because of the employees' warning. The warning should not relieve GES of joint and several liability because GES did nothing to fix the situation. We conclude that the district court incorrectly interpreted the phrase "concerted acts." Statutory construction is a legal question requiring independent appellate review, and "[a] statute should always be construed to avoid absurd results."[16] We previously discussed the meaning of "concert of action" in Dow Chemical Co. v. Mahlum[17]*15 and explained that this doctrine requires more than just agreement to act: Concert of action resembles the tort of civil conspiracy. Halberstam, 705 F.2d at 477.... Both causes of action require an agreement. To prevail in a civil conspiracy action, a plaintiff must prove an agreement between the tortfeasors, whether explicit or tacit
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: * Qualified Name: com.tencent.mm.ui.c.j.1 * Java Class Version: 6 (50.0) * JD-Core Version: 0.7.1 */Vocabulary course The Kriseh Kristang Memrise course introduces you to the vocabulary of Kristang. After signing up for a free Memrise account and joining the course, you will see a series of words, each pronounced by two Kristang speakers separately. Memrise then quizzes you on each word based on a spaced repetition algorithm that takes into account your ability to remember each word, and your own daily goals, which you can set. New units are uploaded to complement theaudio course.Units are presented by Kevin Michael Sim and Linda Longue, and the course is managed by Kevin Martens Wong.Gender identity disorder Gender identity disorder Definition Gender identity disorder is a condition characterized by a persistent feeling of discomfort or inappropriateness concerning one's anatomic sex. The disorder typically begins in childhood with gender identity problems and is manifested in adolescence or adulthood by a person dressing in clothing appropriate for the desired gender, as opposed to one's birth gender. In extreme cases, persons with gender identity disorder may seek gender reassignment surgery, also known as a sex-change operation. Description Gender identity disorder is distressing to those who have it. It is especially difficult to cope with because it remains unresolved until gender reassignment surgery has been performed. Most people with this disorder grow up feeling rejected and out of place. Suicide attempts and substance abuse are common. Most adolescents and adults with the disorder eventually attempt to pass or live as members of the opposite sex. Gender identity disorder may be as old as humanity. Cultural anthropologists and other scientists have observed a number of cross-gender behaviors in classical and Hindu mythology, Western and Asian classical history, and in many late nineteenth- and early twentieth-century pre-literate cultures. This consistent record across cultures and time lends support to the notion that the disorder may be, at least in part, biological in origin. Not all behavioral scientists share this conclusion, however. Gender identity and gender-appropriate behaviors are generally learned. This learning first occurs at home and later outside the home. Behavioral experimentation, particularly when a child is young, is considered normal. As they grow, children will often experiment with a variety of gender role behaviors as they learn to make the fine distinctions between masculine and feminine role expectations of the society in which they live. Some young boys occasionally exhibit behaviors that Western culture has traditionally labeled "feminine." Examples of these behaviors include wearing a dress, using cosmetics, or playing with dolls. In a similar manner, some young girls will occasionally assume masculine roles during play. An example of this behavior includes pretending to be the father when playing house. Some girls temporarily adopt a cluster of masculine behaviors. These youngsters are often designated as tomboys. Most experts agree that such temporary or episodic adopting of behaviors opposite to one's gender is normal and usually constitute learning experiences in the acquisition of normal sex role socialization. In pathological cases, however, children deviate from the normal model of exploring masculine and feminine behaviors. Such children develop inflexible, compulsive, persistent, and rigidly stereotyped patterns. On one extreme are boys who become excessively masculine. The opposite extreme is seen in effeminate boys who reject their masculinity and rigidly insist that they are really girls or that they want to become mothers and bear children. Such males frequently avoid playing with other boys, dress in girls' clothing, play predominantly with girls, try out cosmetics and wigs, and display stereotypically feminine gait, arm movements, and body gestures. Although much less common, some girls may similarly reject traditionally feminine roles and mannerisms in favor of masculine characteristics. Professional intervention is required for both extremes of gender behavior. This disorder is different from transvestitism or transvestic fetishism , in which cross-dressing occurs for sexual pleasure. Furthermore, the transvestite does not identify with the other sex. Adults with gender identity disorder sometimes live their lives as members of the opposite sex. They often cross-dress and prefer to be seen in public as a member of the other sex. Some people with the disorder request sex-change or sex reassignment surgery. Persons with gender identity disorder frequently complain that they were born the wrong sex. They may describe their sexual organs as being ugly and may refrain from touching their genitalia. People with gender identity disorder may try to hide their secondary sex characteristics. For instance, males may try to shave off or pluck their body hair. Many elect to take female hormones in an effort to enlarge their breasts. Females may try to hide their breasts by binding them. Causes and symptoms Causes There is no clearly understood or universally agreed-upon cause for gender identity disorder. However, most experts agree that there may be a strong biological basis for the disorder. The sex of a human baby is determined by chromosomes. Males have a Y chromosome, in addition to a X chromosome, while females have two X chromosomes. The Y chromosome contains a gene known as the testes determining factor. This gene causes cells in an embryo to differentiate and develop male genitals. Embryos without the testes determining factor continue to develop undifferentiated as females. The newly formed male testes release significant quantities of male hormones during the third month of pregnancy, further enhancing male differentiation. This sudden surge of hormones occurs again in males sometime between the second and twelfth week after birth. It is important to note that there is no corresponding feminizing hormonal surge sequence observed in females at this age. These facts provide the biological basis for gender identity disorder. Male hormonal surges must occur not only in sufficient amounts, but also during a short window of time to cause masculinization of the developing infant. If there is insufficient androgen, the hormone primarily responsible for masculinization, or the surge comes too early or too late, the developing infant may be incompletely masculinized. Disruptions of hormonal surges may come from a variety of sources. A partial list includes a disorder in the mother's endocrine system, common maternal stress , or maternal medications or some other toxic substances yet to be identified. Recent post-mortem studies conducted on male-to-female transsexuals, non-transsexual men, and non-transsexual women show a significant difference in the volume of a portion of the hypothalamus that is essential for sexual behavior. While further investigations are needed, these initial studies seem to confirm that one's sense of gender resides in the brain and that it may be chemically determined. In addition to biological factors, environmental conditions, such as socialization, seem to contribute to gender identity disorder. Social learning theory, for example, proposes that a combination of observational learning and different levels and forms of reinforcement by parents, family, and friends determine a child's sense of gender, which, in turn, leads to what society considers sex-appropriate or inappropriate behavior. Symptoms The onset of puberty increases the difficulties for people with gender identity disorder. The subsequent development of unwanted secondary sex characteristics, especially in males, increases a person's anxiety and frustrations. In an effort to cope with their feelings, some men with gender identity disorder may engage in stereo-typical, or even super-masculine, activities. For example, a man struggling with the disorder may engage in such "macho" sports as wrestling and football in order to feel more "male." Unfortunately, the result is usually an increase in anxiety. This anxious state is characterized by feelings of confusion, shame, guilt, and fear. These individuals are confused over their inability to handle their problem. They feel shame over their inability to control what society considers "perverse" activities. Even though cross-dressing and cross-gender fantasies provide relief, the respite is temporary. These activities often leave individuals with a profound shame over their thoughts and activities. Closely associated with shame is guilt, particularly about being dishonest with family and friends. Sometimes people with gender identity disorder get married and have children without telling their spouse about their disorder. Typically, it is kept secret because they have the mistaken conviction that participation in marriage and parenting will eliminate or cure their gender identity problems. The fear of being discovered further raises their anxiety. With some justification, people with gender identity disorder fear being labeled "sick," and being rejected and abandoned by people they love. If an individual's gender identity disorder is profound, a lifestyle change such as occasional cross-dressing may be insufficient. In such a case, gender expression may move from a lifestyle problem to a life-threatening imperative. The result can be extreme depression that requires medical treatment. If sufficiently severe, the imperative may result in gender reassignment surgery. If an individual lacks the psychological commitment to undertake surgery, the result may be suicide. Demographics Gender identity disorder is more prevalent in males than in females. Accurate estimates of prevalence for either males or females are not available. Diagnosis A mental health professional makes a diagnosis of gender identity disorder by taking a careful personal history. He or she obtains the age of the patient and determines whether the patient's sexual attraction is to males, females, both, or neither. Laboratory tests are neither available nor required to make a diagnosis of gender identity disorder. However, it is very important not to overlook a physical illness such as a tumor that might mimic or contribute to a psychological disorder. If there is any question that a physical problem might be the underlying cause of an apparent gender identity disorder, a mental health professional should recommend a complete physical examination by a medical doctor. Laboratory tests might be necessary as components of the physical evaluation.
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778> ok <quiksilver> ubuntu <tux9778> anything i can try threetimes <vertana> quiksilver: I believe you'll fit in here... =p <Threetimes> gnutron: is checked, when I speak into it, it works. But when recording it isn't amplified. <gnutron> maxxist: i dont use compiz but its installed, i think its coupled w/emerald but i'm noy up on yhat. <Threetimes> tux9778: i don't know <ice_cream> humpty ubunty sat on a wall =D <vertana> Threetimes: Under volume control, right click and select preferences and see if you have a digital gain or mic boost option and check it (then enable it) <gnutron> Threetimes: i cant explain that but its a common issue with others also. <Panarchy> does the floodbot block you for writing three lines in quick succession? <Robert_Surcouf> quiksilver: wait to test all the 26000 programs freely available ... <maxxist> gnutron i think its just different window frames and such. but i know it was kinda buggy before. but that was a couple years ago. <Robert_Surcouf> Panarchy,: yes <Panarchy> darn <Panarchy> I have been creating and recreating my linux distrbituion for quite some time now ,(well not compared to other distro's... maybe been working on it for 1-2 months), and I am about to recreate it from scratch (clean Ubuntu installation) for the 7th or 8th time. <Panarchy> To make this as minimal as possible, I would like to remove everything from it, except for the following: GNOME, Ubuntu icons for GNOME, DPKG, Apt-Get (think the real name is Aptitude?), Network Capabilites (for access to internet), Generic Drivers, manpages (unless this can installed via apt-get), GNOME Terminal Emulator <Panarchy> Please tell me what to do in order to limit my Ubuntu installation in that way. Thanks. <Robert_Surcouf> !pastebin | Panarchy <FloodBot1> Panarchy: Please don't flood, use http://paste.ubuntu.com to paste, don't use Enter as punctuation. <ubottu> Panarchy: pastebin is a service to post multiple-lined texts so you don't flood the channel. The Ubuntu pastebin is at http://paste.ubuntu.com (make sure you give us the URL for your paste - see also the channel topic) <Threetimes> vertana: I already tried everything in that window. <Threetimes> gnutron: why can't you explain? <gnutron> maxxist: they seem to improve bells and whistles while everything else like sound gets whacked.. <Panarchy> PS:I Have been recommended debootstrap in the past. Do you think it's a good idea? If so, how do I use it? <gnutron> Threetimes: because i'm not well informed on the subject. <Threetimes> gnutron: ah... <Threetimes> anybody: who is?! <Panarchy> Been having connection issues, can someone say they hear me? <maxxist> gnutron I think ubuntu needs to add a package with a bunch of community maintained sound themes in it. like they did with the gnome themes. Dust is beautiful. <Flannel> Panarchy: Why are you trying to make it minimal? <Panarchy> Flannel: So that I can add on to it with only what I need <Panarchy> You see, I'm creating my own distribution <C4N-S|SEAL45> hey guys <Panarchy> hi <Flynsarmy> Is there any diff between the open source and proprietry nvidia driver? Is one better than the other? <roccity_> hi guys <Panarchy> proprietry probably better <Flannel> Panarchy: You may be more interested in modifying an alternate CD, it's the easiest method of doing that sort of thing: https://help.ubuntu.com/community/InstallCDCustomization <Panarchy> Flannel: I've tried that, and minimal CD, and server CD <Panarchy> oh, and alternate CD <Robert_Surcouf> Flynsarmy: the version available on synaptic are usually good <gnutron> maxxist: you have a good idea there. sound themes would be nice. <jinja-sheep> maxxist: If you love Dust, you can install it... community-themes, i believe. <Panarchy> But still, am running into this problem... that no matter what I do, it still wants so much more!!! <Panarchy> It's like my first gf, she just keeps wanting more <Panarchy> !!! <maxxist> jinja-sheep it is.. and i am using it. but thanx. ;D <Flynsarmy> Robert_Surcouf, if the proprietry one is working fine for me, would it be worth upgrading to an open source one? I wouldn't mind being able to play videos on my laptop without 100% cpu <gnutron> maxxist: i would gladly settle for stable sound period. <jinja-sheep> maxxist: There is a reason. That theme isn't a property of Ubuntu nor is it a reflection of Ubunut. It's just a theme. You know? <jinja-sheep> maxxist: Got it. :) <quiksilver> what's this gnome everyone is talking about? <Flannel> quiksilver: Gnome is the desktop environment for Ubuntu <Dr_willis> !gnome | quiksilver <ubottu> quiksilver: GNOME is the default !desktop environment on Ubuntu. To install it from Kubuntu or Xubuntu, type « sudo apt-get install ubuntu-desktop » in a !terminal. <gnutron> quiksilver: gnome is a popular linux desktop environment <quiksilver> i guess id need to know what a desktop environment is to understand <jinja-sheep> Dr_willis: That auto-bot quote was biased. :\ <quiksilver> off to wiki-pedia <Robert_Surcouf> Flynsarmy: never tried the open source one like nouveau <codename> Hey, how do I check my NVIDIA card <maxxist> gnutron I just wonder sometimes why so many distros had to jump to pulseaudio. like it was the best thing since sliced bread. I havent had much luck with it since they started using it in ubuntu... <codename> I wanna make sure my 9800 is being seen <maxxist> codename nvidia-settings <tux9778> threetimes if i get a headset mic i should be fine? <jinja-sheep> codename: Try System --> Admin --> Nvidia something. <codename> Under GPU, Graphics Processor: GeForce 9800 GT <codename> So is it seen? <Dr_willis> well its seen.. if its using the nvidia drivers is the big question codename <maxxist> if nvidia-settings opens. then chances are the driver is working fine. <Robert_Surcouf> codename: dmesg | grep NVRM <codename> Well I did install via Restrcted <Flannel> quiksilver: Do you have a desktop install? (you're using a mouse, etc?) <codename> [ 10.855062] NVRM: loading NVIDIA UNIX x86_64 Kernel Module 177.82 Tue Nov 4 16:50:05 PST 2008 <quiksilver> yes <Robert_Surcouf> codename: looks good <jinja-sheep> codename: Ooh... 64 bits. Leet. <Threetimes> tux9778: i don't know, try it. If there's any boost 20dB option in Volume Control, try it. <codename> Oh thanks! <codename> LoL <Robert_Surcouf> codename: the 180 are available on synaptic <codename> Really? <quiksilver> Flannel: so its the interface that makes using the desktop possible, and functional <maxxist> codename I have noticed a performance increase by installing the newer 180 drivers. some say stability is less though. they are in synaptic. install nvidia-glx-180 <codename> I'd rather compile it from NVIDIA <Robert_Surcouf> codename: don't ask me what it brings <tux9778> ok thanks i'll try it i tried all the setings i have but how would set skype for wich one sound is coming from mic sound in or out? threetimes <codename> lol
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in Audacity: > highlight a small portion at the end of your recording where you don't speak > go to effect - noise reduction and first choose Get Noise Profile > then highlight the entire recording > again go to effect - noise reduction and then press OK Could you do these two changes to your recording and reupload so I can have another listen please ? I hope everything was clear for you. If there are still questions, don't hesitate to ask. YES ! the volume is at 89.4 dB and totally perfect now. Also the background noise is not disturbing at all. I mark your test OK and I wish you boa sorte with your future recordings. I think for the moment we don’t have a portuguese project on offer, but there is the Multilingual poetry and prose thread here: viewtopic.php?f=60&t=65168 You can choose your own text, which has to be in the public domain ! and you can record it for that collection. And if you don’t speak too fast, I might even practice my Portuguese to prooflisten to your file.Efforts to secure a new deal between the Alberta government and physicians hit another roadblock Friday after the government called the voluntary mediation process "unsuccessful." According to a statement attributed to Health Minister Tyler Shandro Friday evening, the government will maintain current spending moving forward. "The government of Alberta is spending more than ever before on our public health care system … in order to ensure that our public health care system remains sustainable, we must act to maintain physician spending at current levels," the statement reads. "Unfortunately, efforts to achieve this goal were unsuccessful during voluntary mediation with the Alberta Medical Association." At the end of last month, the two sides brought in a mediator to try to break a logjam on the talks surrounding the new master agreement, which is set to expire at the end of March. Both sides agreed on the mediator. The master agreement revolves around the broad relationship between doctors and the government. Changes pending will impact working conditions for provincial doctors, as well as compensation. In their statement, the government said it would now take time to consider "all options" at its disposal. Steve Buick, press secretary for Shandro, said there are no more details available at this time as to what those options might look like. The province said savings gained through curtailing physician compensation costs would be reinvested into reducing surgical wait times, addressing mental health and addictions and investing in continuing care. "Our government believes we can address these priorities, while also keeping our hardworking and dedicated physicians amongst the highest paid in Canada," the statement reads. The province is paying $5.3 billion this year for physicians. Doctors' response In a statement provided to CBC News, Dr. Christine Molnar, head of the Alberta Medical Association, said she was disappointed that mediation had failed. "Physicians offered substantial short-term savings, among other considerations," she wrote. "Our offer was rejected." The AMA confirmed to CBC News that work with the mediator had ended, but that the organization is still open to talks and negotiations. Among the most contentious changes sought by the government are changes to complex modifiers, which would affect how long a doctor must see patients before they tack on extra fees. Lorian Hardcastle, a health professor at the University of Calgary, said she was surprised how quickly talks had broken down. "Different provinces and different physician groups have had controversial or contentious contract negotiations before. But I think that the government has been extremely aggressive in the strategy it has pursued," Hardcastle said. "They have moved really quickly in making cuts in the healthcare system since being elected, so I'm not surprised this issue has come to a head." The potential next steps in the contract negotiations are currently unclear. Hardcastle said she thinks both sides likely assumed they would come to an agreement through voluntary negotiations. "The mediation did not go on that long, so I expect perhaps they'll agree to another round of mediation," she said. "Because the last thing the province or the doctors want is to have no agreement in place at all."Pro-Putin Party Sweeps to Easy Win in Chechnya The pro-Kremlin United Russia party swept to an easy victory in elections Sunday for a local parliament in Chechnya, according to preliminary returns Monday. Russian President Vladimir Putin hailed the vote as a key step in restoring order in the republic, the scene of years of separatist war, but critics of the election, including some Western European observers, said it would do little to foster real democratic decision-making. Early results gave the United Russia party more than 60 percent of the vote in the race for the two-chamber parliament, with the Communist Party winning about 12 percent and the Union of Right Forces 11 percent. "This completes the formal legal procedures of restoring the constitutional system in the Chechen Republic," Putin said in televised remarks. Chechens voted in 2003 to approve a new constitution, followed by a presidential election. People in Chechnya "have again demonstrated in the most convincing way their strength of character, political maturity and organization," Putin said. "They have demonstrated that no one can ever intimidate them." But many political analysts contend that the election will only solidify the power of Ramzan Kadyrov, the pro-Moscow deputy prime minister who commands a paramilitary force that has been implicated in violence and abductions. Kadyrov is widely expected to rise to the presidency of Chechnya next year soon after he turns 30, the minimum age for the office. About 100,000 civilians, soldiers and insurgents have died in two full-scale wars in Chechnya in the last 11 years. While fighting has abated recently, a drumbeat of daily violence continues. The Kremlin is scaling back direct involvement as it pursues a policy of delegating governance and security to its local supporters, in particular Kadyrov. Critics of that policy say Kadyrov, whose father, Akhmad Kadyrov, was Chechnya's president until his assassination last year, has little legitimacy and that it is difficult, if not impossible, to conduct free and fair elections in a climate of fear. "We face a very weak democratic power and a very strong real power, and this real power is out of control," said Andreas Gross, who headed a fact-finding delegation from the Council of Europe, the continent's leading human rights organization. "Real power . . . is based on a legitimacy that is not democratic." Turnout in the elections exceeded 60 percent, according to Chechnya's Central Elections Commission. People openly advocating Chechnya's independence from Russia were not allowed to run in the elections. A separatist Web site condemned the election as a farce. "The overall number of people who really voted will hardly exceed five- to seven-percent," said the separatist Kavkaz Center on its Web site. The Chechen people are "not going to participate in a show organized by their killers and their accomplices." Human rights groups questioned the official turnout figures. "The normally busy center of Grozny remained empty all day," the Russian human rights group Memorial said in a statement Monday. "Low voter turnout was reported by the chairmen of all polling stations that Memorial representatives visited." Speaking at a military base in Grozny, Gross called on the Russian and Chechen authorities to include separatists in the political process. Alu Alkhanov, the president of Chechnya, suggested that he was open to such a dialogue. "I will soon visit Brussels and meet the so-called leaders of Ichkeria," he said at a news conference Monday. Ichkeria is the word separatists use for Chechnya. "There is no creation, development or democratic process without peace. We should promote a normal life for militants in Chechnya and people who happened to move to the West due to certain circumstances and misunderstandings." Deputy Prime Minister Ramzan Kadyrov, who commands a militia implicated in abuses, strengthened his position in regional elections. Peter Finn is the national security editor at The Washington Post. In all, Finn has reported from more than 60 countries for The Post. He was part of a team of editors that oversaw the Pulitzer Prize-winning stories based on the documents leaked by Edward Snowden.A novel catalyst precursor K2TiF6 with remarkable synergetic effects of K, Ti and F together on reversible hydrogen storage of NaAlH4. A synergetic effect of K, Ti and F together on improving the reversible hydrogen storage properties of NaAlH(4) is found by intruding K(2)TiF(6) as catalyst precursor. Around 4.4 wt% of hydrogen can be released from the NaAlH(4)-0.025 K(2)TiF(6) sample within 40 min at 140 °C.Free E-Book The 7-Day Mediterranean Diet Meal Plan By Bill Bradley With recipes by Koula Barydakis, Bill Bradley, and Christine Dutton Go on a culinary journey to the Mediterranean Island of Crete, known as one of the healthiest places in the world. Bill Bradley, Registered Dietitian, lecturer, and cookbook author will teach you how easy it is to follow the most well studied and delicious ways of eating in the world. ↓ Enter Your Email AddressInfo-graphics While the U.S. economy has rebounded, the financial
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Nakayla Souchet - Ada Ave, Aberdeen, ID 208-844-4412 Maimouna Schmink - Underwood Loop Rd, Aberdeen, ID 208-844-7049 Ahmiya Sante - 1100 South Rd, Aberdeen, ID 208-844-3107 Shreyansh Hort - W Bingham St, Aberdeen, ID 208-844-5817 Rocco Malinconico - N Powerline Rd, Aberdeen, ID 208-844-4845 Aarvi Slow - Homestead Rd, Aberdeen, ID 208-844-4220 Stanford Magathan - W Chandler Rd, Aberdeen, ID 208-844-3421 Silver Sieben - E Sterling Ave, Aberdeen, ID 208-844-8299 Anarosa Yamaki - W Lincoln Ave, Aberdeen, ID 208-844-7557 Romon Chesek - W 1078 S, Aberdeen, ID 208-844-7566 Leianna Trombetti - 2300 West Rd, Aberdeen, ID 208-844-3867 Kattleya Stefanov - W 700 S, Aberdeen, ID 208-844-0147 Khasir Mongeon - Desert Rd, Aberdeen, ID 208-844-5111 Chyler Bellfield - Strong Rd, Aberdeen, ID 208-844-2736 Adalea Loest - 2900 West Rd, Aberdeen, ID 208-844-3142 Daleyza Weyher - 1200 South Rd, Aberdeen, ID 208-844-3379 Desiray Morneault - Experiment Station Rd, Aberdeen, ID 208-844-5594 Avishka Ranniger - S 3100 W, Aberdeen, ID 208-844-7620 Leyonna Pils - W 1750 South Rd, Aberdeen, ID 208-844-2964 Saira Arzuaga - S Wapello Rd, Aberdeen, ID 208-844-9848 Sulayman Fornadel - 600 South Rd, Aberdeen, ID 208-844-2748 Loraine Braddock - N Powerline Rd, Aberdeen, ID 208-844-3109 Alleigha Eskins - 3200 West Rd, Aberdeen, ID 208-844-3009 Anden Mayhle - N 4th E, Aberdeen, ID 208-844-0036 Karyna Hadi - Vambahr Rd, Aberdeen, ID 208-844-6827 Taziyah Medal - N 2nd St E, Aberdeen, ID 208-844-6938 Rubani Breuer - N 3rd E, Aberdeen, ID 208-844-7750 Damonei Arhart - Sixth West St, Aberdeen, ID 208-844-8081 Caliegh Wimett - Driscoll Rd, Aberdeen, ID 208-844-5710 Jurni Attix - Custer Ave, Aberdeen, ID 208-844-3037 Corrado Savchuk - 1400 South Rd, Aberdeen, ID 208-844-3000 Tyking Meehl - Fourth West St, Aberdeen, ID 208-844-6876 Noni Hjelmeland - Ada Ave, Aberdeen, ID 208-844-6149 Missael Hastie - W 1750 South Rd, Aberdeen, ID 208-844-8400 Sanari Bucklin - Beach Rd, Aberdeen, ID 208-844-6282 Arna Sajid - W 1600 S, Aberdeen, ID 208-844-8073 Lanasia Palilla - S 5th E, Aberdeen, ID 208-844-2891 Yang Wilger - Springfield Rd, Aberdeen, ID 208-844-5114 Meklit Castoria - W Boise Ave, Aberdeen, ID 208-844-0457 Fathima Espenlaub - Duffin Rd, Aberdeen, ID 208-844-3195 Wells Sanjines - N First West St, Aberdeen, ID 208-844-6672 Helio Isaacs - 2nd St E, Aberdeen, ID 208-844-2870 Afton Druckemiller - 1000 South Rd, Aberdeen, ID 208-844-6381 Jacayden Eloisa - First St W, Aberdeen, ID 208-844-2980 Jhanvi Neuser - Ruff Rd, Aberdeen, ID 208-844-2660 Carrick Mackendrick - 2600 West Rd, Aberdeen, ID 208-844-0129 Liyana Gardine - W 850 S, Aberdeen, ID 208-844-0286 Ramzi Krebbs - S Wapello Rd, Aberdeen, ID 208-844-9677 Yann Pittaluga - Dean Sub Rd, Aberdeen, ID 208-844-6262 Nylea Triesch - N 3rd E, Aberdeen, ID 208-844-0443 Aleyia Galinato - W Boise St, Aberdeen, ID 208-844-9168 Kaled Brasier - Main St, Aberdeen, ID 208-844-4375 Divyansh Guebara - S 2nd St E, Aberdeen, ID 208-844-8008 Jaceion Bungert - 2500 West Rd, Aberdeen, ID 208-844-5262 Masato Owyoung - S 2750 W, Aberdeen, ID 208-844-6809 Kayde Rittler - W Bingham St, Aberdeen, ID 208-844-9371 Wylee Garbrandt - 2900 West Rd, Aberdeen, ID 208-844-6009 Driana Ches - N 2nd St W, Aberdeen, ID 208-844-5245 Ismari Seville - S 3rd St E, Aberdeen, ID 208-844-6153 Samanvi Hoenshell - Cassia Ave, Aberdeen, ID 208-844-6957 Aashir Fairris - N 2nd W, Aberdeen, ID 208-844-2294 Linh Listermann - Lincoln Ave, Aberdeen, ID 208-844-5072 Rosmery Liversedge - 3100 West Rd, Aberdeen, ID 208-844-0166 Lynzie Giustino - S 2950 W, Aberdeen, ID 208-844-3210 Taisei Lomasney - 1200 South Rd, Aberdeen, ID 208-844-9459 Aia Hausenfluck - 2600 West Rd, Aberdeen, ID 208-844-6104 Lisamarie Mitri - Fremont Ave, Aberdeen, ID 208-844-4561 Antony Mantia - S 2500 W, Aberdeen, ID 208-844-0550 Pilar Schuneman - Fingal Rd, Aberdeen, ID 208-844-3617 Michela Tourek - N 725 W, Aberdeen, ID 208-844-9674 Jamaica Kulberg - 5th W, Aberdeen, ID 208-844-1925 Damonie Mcabe - 2100 South Rd, Aberdeen, ID 208-844-2690 Giovani Sumabat - W 2000 S, Aberdeen, ID 208-844-6106 Jozlyn Himmler - 2500 West Rd, Aberdeen, ID 208-844-4457 Wolfgang Musk - Hunsinger Loop, Aberdeen, ID 208-844-9775 Abril Sayas - S 2175 W, Aberdeen, ID 208-844-8873 Breven Hermsmeyer - W 2300 S, Aberdeen, ID 208-844-3853 Nariya Kasdorf - S 2nd W St, Aberdeen, ID 208-844-8480 Roosevelt Care - S 2400 W, Aberdeen, ID 208-844-5232 Emalin Grzebyk - S 2500
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{ opentxs::Lock lock(master_key_lock_); password_duration_ = timeout; } auto Core::Storage() const -> const api::storage::Storage& { OT_ASSERT(storage_) return *storage_; } void Core::storage_gc_hook() { if (storage_) { storage_->RunGC(); } } void Core::password_timeout() const { struct Cleanup { std::atomic<bool>& running_; Cleanup(std::atomic<bool>& running) : running_(running) { running_.store(true); } ~Cleanup() { running_.store(false); } }; opentxs::Lock lock(master_key_lock_, std::defer_lock); Cleanup cleanup(timeout_thread_running_); while (running_) { lock.lock(); // Negative durations means never time out if (0 > password_duration_.count()) { return; } const auto now = Clock::now(); const auto interval = now - last_activity_; if (interval > password_duration_) { master_secret_.reset(); return; } lock.unlock(); Sleep(std::chrono::milliseconds(250)); } } auto Core::Wallet() const -> const api::Wallet& { OT_ASSERT(wallet_); return *wallet_; } Core::~Core() { cleanup(); } } // namespace opentxs::api::implementation Explore More Items Product Description Amazon Kindle is a convenient, portable reading device with the ability to wirelessly download books in less than 60 seconds. Kindle was built for one purpose - reading. Its electronic ink display uses actual ink, so it looks like text on paper. It is nothing like reading on a computer screen. With Kindle, you can read anywhere, even in bright sunlight, without glare. Kindle is designed to disappear in your hands – to get out of the way – so you can get lost in the author’s words. It is as thin as a magazine and weighs less than a paperback, and holds up to 1,400 books, so you carry your library with you. A long battery life means you can read for up to one month on a single charge. Finished your book? With Kindle’s built-in Wi-Fi, you can download your next book wirelessly in less than 60 seconds, right from the device – no computer required. Simple to use – there is no software to install and no syncing necessary. None, because it's wireless and doesn't require a computer to download content. On-device Storage Up to 1,400 books or 2GB internal (approximately 1.25GB available for user content). Cloud Storage Free cloud storage for all Amazon content. Battery Life A single charge lasts up to one month with wireless off based upon a half-hour of daily reading time. Keep wireless always on and it lasts for up to 3 weeks. Battery life will vary based on wireless usage, such as shopping the Kindle Store, web browsing, and downloading content. Charge Time Fully charges in approximately 3 hours via the included USB 2.0 cable connected to a computer. Power adapter sold separately. Wi-Fi Connectivity Supports public and private Wi-Fi networks or hotspots that use the 802.11b, 802.11g, or 802.11n standard with support for WEP, WPA and WPA2 security using password authentication or Wi-Fi Protected Setup (WPS); does not connect to WPA and WPA2 secured networks using 802.1X authentication methods; does not support connecting to ad-hoc (or peer-to-peer) Wi-Fi networks. Detailed Features Elegant, Easy-to-Use Design Lose Yourself in Your Reading The most elegant feature of a physical book is that it disappears while you're reading. Immersed in the author's world and ideas, you don't notice a book's glue, the stitching, or ink. The top design objective is to make Kindle disappear — just like a physical book — so you can get lost in your reading, not the technology. Ergonomic Design Kindle is easy to hold and read. We designed it with long-form reading in mind. When reading for long periods of time, people naturally shift positions and often like to read with one hand. Kindle's page-turning buttons are located on both sides, allowing you to read and turn pages from any position. The new soft-touch, textured back is comfortable to hold and never gets hot in your hands. Never Gets Hot Unlike a laptop, Kindle never gets hot so you can read comfortably as long as you like. Wireless Capability Built-in Wi-Fi Kindle automatically detects nearby Wi-Fi networks at school, home, or your favourite café. At a hotel or café that requires a password? Simply enter the password and connect to the network. Once you have added a Wi-Fi network, Kindle will automatically connect to that network the next time you’re near the hotspot. How Electronic Ink Works Electronic ink uses actual ink particles to create crisp, print-like text similar to what you see in a physical book. Kindle uses proprietary, hand-built fonts to take advantage of the special characteristics of the ink to make letters appear clear and sharp. Reads Like Real Paper, Even in Bright Sunlight Because Kindle's electronic display uses E Ink, it looks and reads like real paper. Kindle's screen reflects light like ordinary paper and uses no backlighting, so you can read as easily in bright sunlight as in your living room. Reading on Kindle Adjustable Text Size Kindle has eight adjustable font sizes to suit your reading preference. You can increase the text size of your favourite book or periodical with the push of a button. If your eyes tire, simply increase the font size and continue reading comfortably. New Font Choices Kindle has three font styles to choose from – all optimised and hand-tuned to provide the best reading experience. Fast Page Turns Kindle now has 10% faster page turns with 6 times less flashing than previous Kindles. We've done this by fine-tuning Kindle's proprietary waveform, the series of electronic pulses that move black and white electronic ink particles to achieve a final grey level for an image or text. Clearest Fonts Kindle uses hand-built, custom fonts and font-hinting to make words and letters more crisp, clear, and natural-looking. Font hints are instructions, written as code, that control points on a font character's line, improving legibility at small font sizes where few pixels are available. Hinting is a mix of aesthetic judgments and complicated technical strategies. We've designed our proprietary font-hinting to optimize specifically for the special characteristics of electronic ink. Images and Photos Kindle's E Ink Pearl display is also great for more graphical content. Images and photos display with high resolution. Rotate Between Portrait and Landscape Mode Switch between portrait and landscape orientation to read maps, graphs and tables more easily. Real Page Numbers Easily reference and cite passages or read alongside others in a book club or class with real page numbers. Using the computing fabric of Amazon Web Services, we've created algorithms that match specific text in a Kindle book to the corresponding text in a print book, to identify the correct, "real" page number to display. Available on tens of thousands of our most popular Kindle books, including the top 100 bestselling books in the Kindle Store that have matching print editions. Page numbers are displayed when you push the menu button. Built-In PDF Reader Native PDF support allows you to carry and read your personal and professional documents on the go. With Amazon's Whispernet service, you can send documents direct to your Kindle and read them anytime, anywhere. You can also add notes and highlights, use the dictionary look-up, and read password-protected PDFs. Magnify your PDFs by viewing them in landscape mode, or zoom in up to 300% to view small print and detailed tables and graphics. You can also convert your PDF document to the Kindle format so that it reflows like a regular Kindle book. Personal Document Delivery Kindle makes it easy to take your personal documents with you, eliminating the need to print. Each Kindle has a unique and customisable e-mail address for sending personal documents and other materials to your Kindle. You can set your unique e-mail address on your page. This allows you and your approved contacts to send Word, PDF and text documents, and pictures to your Kindle via Wi-Fi for no fee. Dictionary and Search Built-In Dictionary with Instant Lookup Come across a word you don’t know? Kindle includes The Oxford Dictionary of English with over 2,50,000 entries and definitions for free. Kindle lets you instantly look up the definition without ever leaving the book – simply select the word with the cursor and the definition will automatically display at the bottom of the screen. Search Wikipedia and the Web Kindle makes it easy to find what you're looking for. Just enter a word or phrase and Kindle will search every instance across your Kindle library, in the Kindle Store, on Wikipedia, or the Web using Google search. WebKit-Based Browser Kindle's experimental web browser is based
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use of Field Emission Gun (FEG) SEMs. The grain size of the material was approximately 8 μm and was determined by a standard mean linear intercept method. This resulted in on average, greater than 500,000 grains being sampled across the cross section of each test specimen. ![Specimen diagram of test pieces used in this research.](materials-06-05275-g002){#materials-06-05275-f002} ![Microstructure of RR1000.](materials-06-05275-g003){#materials-06-05275-f003} The temperature cycle used during the testing was (300--700--300) °C, linearly, in 30 s, which was thought to be representative of a typical in-service TMF cycle for a turbine disc. Clearly concerns have previously been raised regarding the use of pyrometry for this form of testing, since changes can occur in the material's emissitivity if it is subjected to significant periods of time at elevated temperature, causing oxidation. In order to overcome this issue, the emissivity of the material was characterised as a function of time and temperature. It was shown that at 700 °C the emissivity of RR1000 reaches a stable value after 8 h. As such, specimens were pre-oxidised in a furnace for 8 h to create a stable oxide layer prior to the commencement of any TMF experiments. No further changes in emissivity were noted, and subsequently accurate temperature control was achieved throughout the test. In order to evaluate the effect of phase angle on the TMF life of RR1000, tests were performed at ϕ = 0, −45 (CW), −90 (CW + ACW), −135 (ACW), and −180° as shown in [Figure 1](#materials-06-05275-f001){ref-type="fig"}. Tests were performed using a constant mechanical strain range of 1%, resulting in strain R ratios varying between 0 and −∞ depending on the phase angle ϕ. Further tests were performed under IP and −180° OOP loading conditions in which the applied mechanical strain range was varied between 0.8% and 1.4% in order to investigate the effect of this property on TMF life. Failure was defined as the number of cycles to achieve a 10% drop in stress from the stabilised peak stress value at which point on average, a semi-circular crack of length 0.7 mm was recognisable in the sample \[[@B14-materials-06-05275],[@B15-materials-06-05275]\] 3. Results ========== In order to derive a model that accurately describes TMF behaviour, it is of course critical that the data produced by the experiments is of the highest quality possible. In the case of the current work the quality of the test data can be easily determined from the appearance of the mechanical strain--stress hysteresis loops. During the experiments the data returned appears to be of a high quality, allowing for consistent interpretation. [Figure 4](#materials-06-05275-f004){ref-type="fig"} provides examples of the loops obtained from both IP and −180° OOP tests with strain ranges of 1.4%. As would be expected in TMF loops, yield is not particularly well defined due to the changing modulus values as temperature increases in the initial part of the cycle. The change in the minimum stress (whilst the maximum stress remains constant) in the IP loop is also indicative of the competing issues of creep and plastic strain occurring at the cycle strain and temperature extremes. Some cyclic hardening of the plastic behaviour can also be seen to occur between the first and stabilised loading cycles ([Figure 4](#materials-06-05275-f004){ref-type="fig"}a). Similar effects can also be observed in compression in the −180° OOP loop ([Figure 4](#materials-06-05275-f004){ref-type="fig"}b). With the quality of the stress--strain loops established, confidence can be placed in the fatigue lives of the tested specimens. The data from [Table 1](#materials-06-05275-t001){ref-type="table"} for the range of tests is plotted in [Figure 5](#materials-06-05275-f005){ref-type="fig"}. In order to relate isothermal behaviour to TMF, the lives of the tests are normalised by the fatigue life of an isothermal fatigue test on the material at *R* = 0, Δε = 1% at peak cycle temperature (700 °C), and therefore a positive or negative effect of the TMF cycle can be easily demonstrated. Essentially, two studies were undertaken, as described previously. In [Figure 5](#materials-06-05275-f005){ref-type="fig"} tests are conducted at a range of phase angles as described by [Figure 1](#materials-06-05275-f001){ref-type="fig"}, whilst maintaining a constant applied mechanical strain range, Δε = 1%. ![1st and stabilised stress--strain hysteresis loops for (**a**) In-Phase (IP) test, Δε = 1.4%; (**b**) Out-Of-Phase (OOP) test, Δε = 1.4%.](materials-06-05275-g004){#materials-06-05275-f004} materials-06-05275-t001_Table 1 ###### Experimental Data. Phase angle (°) Max Strain (%) Min Strain (%) Strain Range (%) Stabilised Max Stress (MPa) Stabilised Min Stress (MPa) Stabilised Stress Range (MPa) Direction Normalised *N*~f~ ----------------- ---------------- ---------------- ------------------ ----------------------------- ----------------------------- ------------------------------- ----------- ------------------- 0 0.98 −0.03 1.01 978 −763 1741 CW 0.49 0 1.2 0 1.2 925 −1159 2084 CW 0.271 0 1.4 −0.01 1.41 1125 −1082 2207 CW 0.156 0 0.79 −0.02 0.81 933 −631 1564 CW 12.5 Unbroken 0 0.89 −0.02 0.91 1019 −681 1700 CW 0.656 −45 0.74 −0.3 1.04 1045 −849 1894 CW 0.75 −90 0.48 −0.52 1 857 −925 1782 ACW 1.198 −90 0.52 −0.49 1.01 945 −895 1840 CW 1.243 −135 0.27 −0.74 1.01 826 −993 1819 ACW 1.385 −135 0.32 −0.7 1.02 741 −1049 1790 ACW 1.219 −180 0.05 −1.05 1.1 865 −982 1847 ACW 1.12 −180 −0.01 −1.22 1.21 926 −1047 1973 ACW 0.729 −180 0 −1.41 1.41 1105 −1070 2175 ACW 0.13 −180 0 −0.81 0.81 630 −864 1494 ACW 8.703 The conditions of these tests offer an interesting opportunity for comparison, since although the *R* ratio varies from test to test, the selected phase angles provide identical strain--temperature paths for portions of each cycle. It is clear that phase angle significantly affects TMF life, with a gradual decrease in life as the phase angle increases from −180° to 0°, as shown in [Figure 5](#materials-06-05275-f005){ref-type="fig"}. [Table 1](#materials-06-05275-t001){ref-type="table"} describes further IP and OOP tests for strain ranges between 0.8% and 1.4%. These results form the basis for a predictive model for TMF behaviour described within this paper. ![Phase angle (ϕ) *vs*. number of thermo-mechanical fatigue (TMF) cycles to failure (*N*~f~) for constant strain range (Δε) of 1%.](materials-06-05275-g005){#materials-06-05275-f005} 4. Discussion ============= Based on the wide range of variables which occur during a TMF test it is clear that a lifing approach capable of holistic data fitting may not be possible. However, an objective of the current work is to assess possible lifing strategies in order to provide a basis for a more widespread approach. As such, the discussion will focus on the advantages and drawbacks of methods based around mean stress, stabilised stress range and crack propagation life. Based on the results produced within this work, no difference was seen between specimens loaded in a clockwise (CW) or anticlockwise (ACW) direction around the
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<h1 class="text-highlight heading2"> <a href="#">Multiconsulta 2018</a> </h1> <a href="#" class="consultations-header__link"> Ver todas las preguntas <%= icon "media-play" %> </a> </div> </div> <div class="columns mediumlarge-3"> <div class="consultations-header__extra"> <div> <span class="consultations-header__extra-title"> Votación a partir de: </span> <span class="consultations-header__extra-date"> 02/06/2018 </span> </div> </div> </div> </div> </div> </div> <div class="row column consultations-title"> <h1 class="heading1"> <!-- IF the question is longer than 145 chars, the heading class should be heading2 instead. --> ¿Quieres remunicipalizar el agua y que se gestione participativamente? </h1> <div class="text-center"> <a href="#"><strong>#MulticonsultaAigua</strong></a> </div> <div class="text-center"> <a href="#" disabled class="button large button--sc consultations-title__cta"> Vota <span class="button__info">a partir de 10/06/2018</span> </a> </div> </div> Linh Dinh: Our Refugee Future Linh Dinh reflects on the current refugee crisis, refugee movements of the past, and how we should accept our inevitable ‘refugee future’. Vietnamese businesses in Leipzig of the former East Germany During the current refugee crisis in Europe, it is said that there are many imposters among genuine refugees from Syria, Iraq, Afghanistan, Libya and Yemen, all countries, incidentally, that America and its allies have destroyed. Too many of them are men, it is pointed out, and they’re generally not dressed badly enough. Many have smart phones. When the Vietnamese boat people fled Communism after the Vietnam War, the percentage of men was also extremely high. Many families could only afford the smuggler’s fee for a single member, and so often the oldest son would be dispatched on the arduous and perilous journey. It was hoped that this individual might become a stepping stone to get the rest out, or he can send desperately needed money back home. There is always an economic reason behind a refugee crisis. People flee because they can no longer make a living due to a tyrannical government, foreign intervention or evil ideology, not just bombs falling. During the Vietnam War, Vietnamese only became internal refugees, but after Communism had triumphed, they fled overseas because many could not tolerate living under a twisted ideal concocted in Germany then refined in Russia. Their society had been deformed to an unrecognizable degree, just as Syria, Iraq, Afghanistan, Libya, Yemen and the Ukraine have been violently made over by American aggression disguised as high-minded rescue. Judeo Christianity has bred a perverted mindset that defines the wholesale destruction of a society as its salvation. The Western world view rests on a messianic foundation. When a white family in Minnetonka, say, adopt an Asian or African orphan, they’re acting on this impulse, but this can also be used as the rationale for the US bombing of the poor kid’s country and all of his extended family. We’re here to save you. France completed its conquest of Vietnam in 1882. During World War I, it brought 92,000 Vietnamese to France to help it fight Germany. Around 30,000 of these died in the trenches. Though most survivors returned home, some stayed to work in factories, and thus, the first overseas Vietnamese community was formed. The invaders are often invaded by the invaded. There are now 300,000 Vietnamese in France. Moreover, nearly 10% of France is Muslim, most of whom are derived from its former colonies of Algeria, Morocco and Tunisia. Syrian grocery store in Leipzig, Germany There are Pakistanis in Europe posing as Syrian refugees, it is observed, but if a Pakistani is from a region attacked by American drones, shouldn’t he count himself as a war refugee? Of course, this doesn’t mean his next address should be in Berlin. He can just move to Lahore. For the last several centuries, however, the West has been busy remaking the rest of the world in its image, and so every black, brown or yellow man is also a bastard Westerner. Already wearing a T-shirt flaunting some retarded English, sporting a Cowboys or Yankees cap, listening to Hotel California or Lady Gaga and mispronouncing phrases of the lingua franca, your average car mechanic or street peddler in Ranchi or Accra will see the West, all of it, as a locus of power, opportunity and wealth, as an ideal, so of course many wouldn’t mind moving there if given a chance. Still, it is quite an exertion to do so, and the ties to one’s homeland are not something to sever so casually. It often takes extreme violence to eject a person from all that he’s known and loved, and here is where the United States most eagerly jumps in. As the world’s foremost purveyor of war, we will provide. The West violates borders, then cringes when its own are ignored. Of course, no one wants to see his society turned upside down. This upheaval could be arrested if only the West would stop wrecking other peoples’ homelands, but this won’t happen. On a planet of exploding populations, dwindling resources and contracting economies, war will only become more pervasive. Many players, Western or otherwise, will instigate it in all corners of this exhausted earth. Massive refugee flows will be the wave of our near future. The mess in Europe is only a preview, so you better get used to it, and you should also consider the likelihood that you yourself will become a desperate escapee who must risk death to start all over in a strange land. Border walls will go up, but there are always ways around walls. Guards can be bribed. I’m a refugee, and so are my entire family. My parents became refugees twice. They fled North Vietnam in 1954, then South Vietnam in 1975. By early April of that year, Hue, Danang and Nha Trang had fallen, and there was much panic in Saigon, where I was living. On April 8th, the Presidential Palace was bombed by Nguyen Thanh Trung, a renegade South Vietnamese pilot whose given name actually means “loyal.” A bomb hit the terrace, another landed in the garden. I was downtown that day and saw the commotion. Days later, my grandfather placed my 11-year-old ass on his lap and rather testily said, “Who cares if other people are leaving, you’re staying here with grandpa, right?” “Yes, grandpa.” Of course, it wasn’t my decision to make. My father, a lawyer and ex congressman, had already arranged for his secretary, me and my five-year-old brother to evacuate with a Chinese family. One of their daughters had been employed by the Americans, so they had a way out, but since they didn’t want to lose their considerable properties to lunge into the unknown, the parents and younger kids stayed behind, and that’s why they could sell three spots to my dad. It was the gravest of mistakes. Within weeks, they would lose everything anyway. Giving me money, my father said, “Two thousand bucks should last you a year.” American bills, I noticed, were less colorful than Vietnamese ones, though longer and crisper. After sewing this cash into the hem of my blue shorts, made of rayon and extremely hot, my grandmother advised, “Whatever you do, don’t take these off,” and I didn’t for nearly a month. I didn’t trust the secretary. Later, this cantankerous woman would become my stepmother. Sickly birthed by history, it was a disastrous marriage. Three of us, then, left with false papers, but no refugee ever gives a shyster about legal niceties. Before being bused to the airport, we stayed at an American compound for four days. Already, Saigon seemed very far away. On the evening of April 27th, just hours before North Vietnamese rockets showering on Tan Son Nhat disabled runways and killed scores of people, mostly civilians, I got on a C-130. No Vietnamese had an idea where it would land. My father was left behind, of course, but I was too dazzled by this strange adventure to even think about him. The war had come to me only through the media. Open a newspaper and you would see VC corpses lying in disarray. Turn on the radio and you could hear how our side was winning. In the middle of the war, Saigon movie theaters even showed American movies of World War II. Sitting in air-conditioned rooms, Saigonese could enjoy elaborately staged scenes of diving jets, exploding bombs, burning houses, collapses bridges and incinerated cities.
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and the top quark $m_{\rm t}$ or the vector-like $M_V$ masses, emphasizes the reductionism of parameterization which is inherent in No-Scale 5. The SPS3 benchmark, which has been our standard control sample in recent work, was chosen in some part for it’s viability in the face of earlier generation search results. This accounts, of course, for it’s comparably heavy LSP mass. The crystal clear exclusion of this model, and likewise of CMSSM representatives in its not-so-immediate vicinity, therefore speaks quite strongly to the current trouble which the mSUGRA/CMSSM framework is experiencing. The analysis of Ref. [@PAS-SUS-11-003] concluded that squark and gluino masses of 1.25 TeV may now be excluded for values of the unified scalar mass at the GUT scale of $m_0$ $<$ 530 GeV. However, as depicted by the light stop squark, gluino, and right-handed up squark mass contours in Figure (\[fig:Wedge\_Masses\]), the No-Scale 5 model space does not share a similar fate. Our estimated lower bound on the single 5 model parameter $M_{1/2}$ of 485 GeV translates into a lower bound on the gluino mass of 658-674 GeV for the entire model space, notably below the gluino mass constraint of 1.25 TeV established for the CMSSM for $m_0$ $<$ 530 GeV. In a similar vein, we choose the right-handed up squark $\widetilde{u}_{R}$ to graphically represent all the heavy squarks, and we likewise discover that the lower bound on $m_{\widetilde{u}_{R}}$ to be 956-1000 GeV, also substantially below the CMSSM squark mass constraint of 1.25 GeV for $m_0$ $<$ 530 GeV. When considering all the heavy squarks ($m_{\widetilde{t}_{2}}$,$m_{\widetilde{b}_{R}}$,$m_{\widetilde{b}_{L}}$,$m_{\widetilde{u}_{R}}$,$m_{\widetilde{u}_{L}}$,$m_{\widetilde{d}_{R}}$,$m_{\widetilde{d}_{L}}$), the lower mass constraints in the 5 model space lie within 854-1088 GeV. It is important to note again that the light stop $\widetilde{t}_1$ mass is less than the gluino mass in 5, apparent through the unique mass hierarchy $m_{\tilde{t}} < m_{\tilde{g}} < m_{\tilde{q}}$, thus the light stop mass limit will also be much less than that of the CMSSM, with an 5 light stop minimum mass of about 520 GeV. Ultra-High Jet Multiplicities ============================= The ultra-high jet signal of No-Scale 5 was first discussed in Refs. [@Maxin:2011hy; @Li:2011hr], and is based upon the stable sparticle hierarchy $m_{\tilde{t}} < m_{\tilde{g}} < m_{\tilde{q}}$ of a light stop and gluino, much lighter than all other squarks, which exists across the full model space. This mass hierarchy is expected to strongly generate back-to-back pair production events, [*e.g.*]{} of two heavy squarks $\widetilde{q}\,\widetilde{\overline{q}}$, which proceed by a decay such as $\widetilde{q} \rightarrow q \widetilde{g}$, followed by (where we identify the virtual tops with parentheses) $\widetilde{g} \rightarrow \widetilde{t}_{1} (\overline{t}) \rightarrow t \overline{t} \widetilde{\chi}_1^{0} \rightarrow W^{+}W^{-} b \overline{b} \widetilde{\chi}_1^{0}$ or $\widetilde{g} \rightarrow \widetilde{t}_{1} (\overline{t}) \rightarrow b \overline{t} \widetilde{\chi}_1^{+} \rightarrow W^{-} b \overline{b} \widetilde{\tau}_{1}^{+} \nu_{\tau} \rightarrow W^{-} b \overline{b} \tau^{+} \nu_{\tau} \widetilde{\chi}_1^{0}$ (plus conjugate processes), which produces up to eight primary jets, considering only the initial hard scattering cascade. This count may be substantially increased by the further cascaded fragmentation and hadronization into final state showers of photons, leptons, and mixed jets. We have proposed a specific alternative to the leading “CMS” style intermediate jet count $(3,4,5)$ SUSY searches which is retuned for the emphasis of high and ultra-high $(9,10,11,12,\ldots)$ jet content signals. The details of the proposed cutting strategy, which we will refer to by the “ULTRA” shorthand, are given in Section (IV) of Ref. [@Maxin:2011hy]. Although various optimizations in the limiting jet count and transverse momentum $p_{\rm T}$ per jet were considered for the ULTRA cuts in the cited work, we settled there on, and maintain here, the aggressive combination of ($p_{\rm T} > 20$, ${\rm jets} \ge 9$) as the baseline indicator of this selection procedure. The simultaneous reduction of the $p_{\rm T}$ jet threshold from $50$ relative to the CMS style cuts is an essential parallel ingredient in the prescription for revealing an enhanced quantity of softer jets. We do, however, maintain demands that the two leading jets carry $100$ GeV of transverse momentum each. Pseudo-rapidity cuts of $\eta \le 3$ for all jets, and of $\eta \le 2$ for the leading jet, are likewise enforced. Since the ultra-high jet regime is greatly suppressed in the SM backgrounds, we have been able to relax certain of the harsh cuts which are very effective for separating out the MSSM in intermediate jet searches, but which simultaneously exert a costly attrition against the No-Scale 5 signal. Specifically, we effectively disable the cuts on the electromagnetic fraction per jet, $\alpha_{\rm T}$ and the missing energy ratio $R(H_{\rm T}^{\rm miss})$. These distinctions are critical, as we shall elaborate in Section (\[sct:less\]), to the success of ultra-high jet multiplicity search strategies. We emphasize again though, validating the old adage that less is sometimes more, that the ultra-high jet blockade itself forms a sufficiently strong discriminant against both the SM and typical mSUGRA/CMSSM attempts at a post-SM solution. A cautious reconsideration of lower order SM background contributions will be the topic of Section (\[sct:bgs\]). In more recent work [@Li:2011gh; @Li:2011rp], we have undertaken a massive Monte Carlo simulation of the collider-detector response of the the full bare-minimally constrained [@Li:2011xu] parameter space of No-Scale 5, modeling both the present LHC center of mass energy $\sqrt{s} = 7$ TeV and upgrades which extend into the bright future of a $\sqrt{s} = 14$ TeV beam. In addition to a prediction for the absolute detection prospects of a given model under certain conditions, there are two sensible modes of comparison which one may consider: A) it is possible to contrast competing models, taking for example respective elements from the viable CMSSM and 5 parameter spaces, while keeping the detector cut methodology constant; B) one may highlight enhancements in the visibility of a single model which are attributable to changes in the search methodology, and in particular to the data selection cuts which are employed. Both comparative modes have the advantage over an absolute study that particular uncertainties may be expected to cancel between the respective analyses. We have considered both modes A and B in the past, and will revisit both again here, although our primary interest will be with regards to mode B, for the reasons described following. Immediately, our interest has been greatly piqued by the announcements made during the recent conference season that various analyses of LHC data in the high jet multiplicity $(6,7,8,\ldots)$ channels are currently underway. Specifically, the ATLAS collaboration stated that they have amassed $1.23~{\rm fb}^{-1}$, and presented analyses of up to $1.0~{\rm fb}^{-1}$ for the mono-jet and di-jet channels with no evidence of new physics. Results for searches targeted at exotic models, in five or more jets with a per jet transverse momentum threshold of $p_{\rm T} \ge 50$ GeV, remain pending. In Ref. [@Collaboration:2011tq], the ATLAS collaboration looked at multi-jet searches up to 6 jets, applying a very hard Cut of $p_{\rm T} \ge 60$ GeV, although the data sampling was only $2.4~{\rm pb}^{-1}$. The CMS collaboration meanwhile presented new data at the level of $1.1~{\rm fb}^{-1}$ for mono and di-jet searches, but reverted to the prior level of $35~{\rm pb}^{-1}$ for the study of events with $\ge 6$ jets from pair-produced gluinos. While the stated target of CMS searches into this high jet territory [@Chatrchyan:2011cj] is the search for exotic R-parity violating SUSY models and Technicolor, any basic experimental physics results are of course model-independent, and we still take notice. A most interesting physics analysis summary [@PAS-SUS-11-003] has also been released by the CMS collaboration, focusing on application of the $\alpha_{\rm T}$ variable, but in some places distributing events binned by integral jet count from 2
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return; } xtimer_t timer; mutex_t mutex = MUTEX_INIT; timer.callback = _callback_unlock_mutex; timer.arg = (void*) &mutex; mutex_lock(&mutex); _xtimer_set64(&timer, offset, long_offset); mutex_lock(&mutex); } void _xtimer_periodic_wakeup(uint32_t *last_wakeup, uint32_t period) { xtimer_t timer; mutex_t mutex = MUTEX_INIT; timer.callback = _callback_unlock_mutex; timer.arg = (void*) &mutex; /* time sensitive until setting offset */ unsigned int state = irq_disable(); uint32_t now = _xtimer_now(); uint32_t elapsed = now - (*last_wakeup); uint32_t offset = (*last_wakeup) + period - now; irq_restore(state); if (elapsed >= period) { /* timer should be fired right now (some time drift might happen) */ *last_wakeup = now; return; } mutex_lock(&mutex); _xtimer_set64(&timer, offset, 0); mutex_lock(&mutex); *last_wakeup = now + offset; } #ifdef MODULE_CORE_MSG static void _callback_msg(void* arg) { msg_t *msg = (msg_t*)arg; msg_send_int(msg, msg->sender_pid); } static inline void _setup_msg(xtimer_t *timer, msg_t *msg, kernel_pid_t target_pid) { timer->callback = _callback_msg; timer->arg = (void*) msg; /* use sender_pid field to get target_pid into callback function */ msg->sender_pid = target_pid; } void _xtimer_set_msg(xtimer_t *timer, uint32_t offset, msg_t *msg, kernel_pid_t target_pid) { _setup_msg(timer, msg, target_pid); _xtimer_set64(timer, offset, 0); } void _xtimer_set_msg64(xtimer_t *timer, uint64_t offset, msg_t *msg, kernel_pid_t target_pid) { _setup_msg(timer, msg, target_pid); _xtimer_set64(timer, offset, offset >> 32); } /* Prepares the message to trigger the timeout. * Additionally, the xtimer_t struct gets initialized. */ static void _setup_timer_msg(msg_t *m, xtimer_t *t) { m->type = MSG_XTIMER; m->content.ptr = m; t->offset = t->long_offset = 0; } /* Waits for incoming message or timeout. */ static int _msg_wait(msg_t *m, msg_t *tmsg, xtimer_t *t) { msg_receive(m); if (m->type == MSG_XTIMER && m->content.ptr == tmsg) { /* we hit the timeout */ return -1; } else { xtimer_remove(t); return 1; } } int _xtimer_msg_receive_timeout64(msg_t *m, uint64_t timeout_ticks) { msg_t tmsg; xtimer_t t; _setup_timer_msg(&tmsg, &t); _xtimer_set_msg64(&t, timeout_ticks, &tmsg, thread_getpid()); return _msg_wait(m, &tmsg, &t); } int _xtimer_msg_receive_timeout(msg_t *msg, uint32_t timeout_ticks) { msg_t tmsg; xtimer_t t; _setup_timer_msg(&tmsg, &t); _xtimer_set_msg(&t, timeout_ticks, &tmsg, thread_getpid()); return _msg_wait(msg, &tmsg, &t); } #endif /* MODULE_CORE_MSG */ static void _callback_wakeup(void* arg) { thread_wakeup((kernel_pid_t)((intptr_t)arg)); } void _xtimer_set_wakeup(xtimer_t *timer, uint32_t offset, kernel_pid_t pid) { timer->callback = _callback_wakeup; timer->arg = (void*) ((intptr_t)pid); _xtimer_set64(timer, offset, 0); } void _xtimer_set_wakeup64(xtimer_t *timer, uint64_t offset, kernel_pid_t pid) { timer->callback = _callback_wakeup; timer->arg = (void*) ((intptr_t)pid); _xtimer_set64(timer, offset, offset >> 32); } void xtimer_now_timex(timex_t *out) { uint64_t now = xtimer_usec_from_ticks64(xtimer_now64()); out->seconds = div_u64_by_1000000(now); out->microseconds = now - (out->seconds * US_PER_SEC); } /* * The value pointed to by unlocked will be set to 1 if the thread was removed from the waiting queue otherwise 0. */ static void _mutex_remove_thread_from_waiting_queue(mutex_t *mutex, thread_t *thread, volatile uint8_t *unlocked) { unsigned irqstate = irq_disable(); assert(mutex != NULL && thread != NULL); if (mutex->queue.next != MUTEX_LOCKED && mutex->queue.next != NULL) { list_node_t *node = list_remove(&mutex->queue, (list_node_t *)&thread->rq_entry); /* if thread was removed from the list */ if (node != NULL) { if (mutex->queue.next == NULL) { mutex->queue.next = MUTEX_LOCKED; } *unlocked = 1; sched_set_status(thread, STATUS_PENDING); irq_restore(irqstate); sched_switch(thread->priority); return; } } *unlocked = 0; irq_restore(irqstate); } static void _mutex_timeout(void *arg) { /* interrupts are disabled because xtimer can spin * if xtimer_set spins the callback is executed * in the thread context * * If the xtimer spin is fixed in the future * interups disable/restore can be removed */ unsigned int irqstate = irq_disable(); mutex_thread_t *mt = arg; mt->blocking = 0; _mutex_remove_thread_from_waiting_queue(mt->mutex, mt->thread, &mt->dequeued); irq_restore(irqstate); } int xtimer_mutex_lock_timeout(mutex_t *mutex, uint64_t timeout) { xtimer_t t; mutex_thread_t mt = { mutex, thread_get_active(), .dequeued = 0, .blocking = 1 }; if (timeout != 0) { t.callback = _mutex_timeout; t.arg = &mt; xtimer_set64(&t, timeout); } int ret = _mutex_lock(mutex, &mt.blocking); if (ret == 0) { return -1; } xtimer_remove(&t); return -mt.dequeued; } int xtimer_rmutex_lock_timeout(rmutex_t *rmutex, uint64_t timeout) { if (rmutex_trylock(rmutex)) { return 0; } if (xtimer_mutex_lock_timeout(&rmutex->mutex, timeout) == 0) { atomic_store_ex
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.62756616e-05, z: -.00415316038} rotation: {x: -1.40765577e-09, y: -2.93770306e-08, z: 2.74363615e-10, w: 1.00000012} scale: {x: .999999881, y: 1, z: 1} - bone: RightLips hash: -1558564409 position: {x: -.00145957619, y: 0, z: -.00240667816} rotation: {x: -1.78700468e-08, y: 1.56863433e-09, z: -4.99532238e-09, w: 1} scale: {x: 1, y: 1, z: .999999762} - bone: RightLipsInferior hash: 921042654 position: {x: -.00255836546, y: .00033454597, z: -.0104915984} rotation: {x: 4.28117319e-10, y: -4.41758523e-08, z: -5.66650371e-09, w: 1} scale: {x: .999999762, y: .999999762, z: .999999762} - bone: RightLipsSuperiorMiddle hash: -2093673696 position: {x: -1.76765025e-05, y: 4.12669033e-06, z: 2.57343054e-05} rotation: {x: -6.243705e-07, y: .00165742321, z: 1.19091214e-06, w: .999998689} scale: {x: 1.00000012, y: .999999881, z: 1} tweenPoses: [] tweenWeights: [] Goniatites, Freestanding Sold by the each. Goniatites are the ancient ancestor to the modern day Nautilus. A Marine Cephalopod approx. 350 million years old. These fossils are found in the Atlas Mountains of Morrocco. Comes in 3 sizes and are freestanding. All fossils come with an information card for each fossil. SKU: GFErotica The hungry toil a lot. Sometimes it’s an invisible growl. Sometimes, an arid wail. Too weak for anything from having been out of grain or fruits or rain. Chin resting on the palm, frail fingers stretching just below the lower lip, they scour their flaky surface. Their quiet is disquieting. They’re not a frequent meet. And ironically enough, they wear yellow (which to me has always been a conspicuous colour). I often find myself wanting to be held closely- a starched embrace, a tug of the hand, a breath into the side of my neck. Most of living happens without meeting with any of this. All I can do at such times is reach for a warm pair of socks and slip my feet in. And that’s what I did, seated in the wrought iron chair of the open half of Café Kunga of a town in the lower Himalayas. It may not have been all too chilly but the grayish blue clouds looked just like the colour of my jacket that twirled around my bag and it made me want to pull it over my shoulders just to know a layer of warmth closely. I could see it among the loud number of colourful high-school student-travellers at the table behind me, the warmth. It was visible in the conversation between an old couple and a brown haired girl at the table next to mine. It hung in the silence another grey-haired couple shared- long gazes at each other-sitting at another adjoining table (The wife, she looked over at me a few times, possible wondering what I was looking around at). I met with it too, momentarily at my table, as the waiter came to me with my order of a tea. Yet, it wasn’t quite there. I tried to create it between my pen and the pages of my journal as I sat there with my hands jiving in my running letters, a method to the madness of my feelings. Finally it spurred. In the form of a few, quiet tears, actually. The warmth. It melted the scum inside my nose as if it were soft ice. I didn’t care if there was anybody watching. My tea was done and I was leaving anyway; there’s nothing I’m going to find here. Not that I knew what I wanted. I got up, ready to get out of there as I began collecting my things, when I saw a girl at the table diagonally behind me, sitting without company. She appeared to be as old as me, if not younger, an IPad in her hand that she was staring at. Should I go up to her? Just two travelers befriending each other. What will I say though… what will we have to talk about? Rejection from a complete stranger couldn’t be all that downright. Easing my hair down from a bun, I went up to her. As it turns out, rejection from a stranger CAN feel quite curt. I asked her if I could join her at her table. “You want my table?” is what she understood of it. “NO. Could I sit here at this table…with you?” A closer look at her features made me wonder if she was from Myanmar or Nepal or Bhutan. She had an expression of worry on her face. “Nepal!” I thought. It was the morning of the most disastrous earthquake in the history of Nepal. “Are you from Nepal?” I asked her looking at the maps changing shapes on her Ipad. “No. From Japan.” The way she said this was both meek and cold. I gathered I wasn’t welcome. “Oh okay. I’ll just go back then. I’m sorry for being a bother.” I said, hoping that would make some sense to her. My moist eyes looked for a place to hide. Now I felt self-conscious; I wanted to leave without having anybody see my tears and rushed off to the roofed half of the restaurant from where the exit was. I put my hair back into a bun, making my way to the payment counter. The relief of the knowledge that I would never see any of the faces of those around my table at the other, now invisible end of the café! The payment counter, which stood before me, was in no mood to entertain me either; there was nobody attending it. I looked around for almost a minute. Still nobody. I turned around my head again and a waiter at a distance raised his hand indicating that somebody would be there soon. I can’t lay a finger on why, but just being the one to occupy the air and the land of this beautiful town was a seething disappointment. My eyes, now dry, turned toward door of the café: a Caucasian man sat at the table beside it; with a straight back, his hand leaning next to a cup on the table, his eyes staring straight. Or maybe he was looking down into his cup, because when I found myself walk up to him I remember feeling swooned for the briefest moment as he looked up with green eyes. Zero shits were given about possible rejection by another stranger. “I was just getting bored all by myself. Would it be okay if I took your table?” Blank stare. Ah..European! “Do you speak English?” “Yes.” He said with two heavy nods. “Would be okay if I sat down with you?” “Okay..ok.” He pointed toward the chair without a smile. He didn’t smile. His ears were both pierced and he wore tiny silver rings on each. His reddish hair was cut crew and he didn’t smile. He wore yellow and he didn’t smile. If I were holding him back- seeing as his cup was empty- he let me. I did a lot of superficial asking and he did very thoughtful monosyllabic answering. It was difficult for him to form sentences, I could see that. He would squint his eyes as if to convey the question in his mind. It seemed to me he repeatedly decided against letting it out of his lips. His lips were so red! He wasn’t particularly sexy…that’s not how I saw him. Not yet. And just then a slight line of his teeth pushed through his lips. He was smiling. Just like how sometimes a trail of sweat can be felt making its way down your eyebrow, I felt my slime slowly ooze out of me. Too soon. Despite his leisurely behaviour, I couldn’t still tell with certitude if I was wanted too. He asked me a couple of personal questions- if I had siblings, where I was from, how old I was- none suggestive of touch or sexual intrigue. There were long pauses awkward enough for him to fly his thoughts back Reims in France (where he was from). I had to bring him back. At least try to, one more time. I took my chapstick out of the bag and drew a line around my lips without looking
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> ChrisH: nothing about a time based release is relaxed :-) <ChrisH> thom: Nah. I meant the "we can't release Sarge because the libfoobar could possibly violate a patent of Microsoft that we heard rumors about at the bus station". <Mithrandir> daniels: actually, I get permission denied. :P <ChrisH> So Ubuntu was created out of the need for fast releas cycles for end-users rather than getting rid of Debian-political problems? <smurfix> thom: ... except for the fact that Ubuntu has a few people that get told "fix it", while Debian ... well, that rant would be somewhat off-topic here. <Mithrandir> ChrisH: the biggest problem with Debian's release cycle is not that it's slow, it's that it's so freaking unpredictable. <daniels> Mithrandir: shame! <daniels> :P <Mithrandir> I waaant myyy craaack <mjg59> thom: Yeah. My output looks nothing like that. <mjg59> thom: http://tyrosine.codon.org.uk/~mjg59/scan <thom> woah <thom> ok, so that's changed rather dramatically <mjg59> That's with an ipw2100 <mjg59> So I need to fix up netapplet. Sigh. <thom> fun <mjg59> It's either kernel or wireless-tools <thom> wonder if NM will cope with that <thom> mjg59: i'm on sid's wireless-tools <mjg59> Ah. Probably kernel, then. <mjg59> Unless mine have come from experimental, somehow <mjg59> Hmm. No, I'm actually behind sid it seems * mjg59 likes finally having a local mirror <daniels> local mirrors are sweet <ChrisH> Mithrandir: Isn't the Debian release manager working for Ubuntu, too? ;) <daniels> ChrisH: no <Mithrandir> ChrisH: the Debian Release Manager is a team consisting of three people (iirc), one of which is working on Ubuntu. <daniels> well, the RM (who just resigned) does not; one of the release team members does, the other does not <Mithrandir> daniels: I thought aba was a RA now as well? <ChrisH> When I first read "release manager *team*" I thought: thank god! <daniels> Mithrandir: oh? well yeah, then that would be 1/3. <ChrisH> Having single persons do such an important job alone is probably the biggest flaw in debian. <smurfix> ChrisH: Quite a few Debian jobs share that problem. <daniels> this is #debian material, dudes * sid77 goodbye all! <ChrisH> I'm just trying to find out if I could help contribute to Ubuntu while staying mentally sane. <thom> we'd like to think we're mostly sane... besides fabio <fabbione> thom: true :-) <fabbione> I AM NOT SANE <fabbione> :P <daniels> ChrisH: here's a tip -- don't maintain X ;) <fabbione> ChrisH: what would you like to do beside X? <daniels> or firefox <daniels> i hear the firefox maintainer is totally insane <fabbione> or mozilla <fabbione> or thunderbird <fabbione> that btw keeps crashing once in a while... <ChrisH> fabbione: I had prepared a page about myself: http://workaround.org/ubuntu/ <fabbione> ChrisH: checking <thom> fabbione: thunderbird sucks, kthxbye :-) <daniels> ChrisH: we can't decide for you ;) <ChrisH> fabbione: I couldn't decide yet whether to put the page up on the MaintainerCandidates page. <ChrisH> daniels: But I can abuse you to help me make up my mind. :) <fabbione> ChrisH: well there is a lot you can do.. but you need to find your own path <fabbione> doing what you feel more comfortable with <daniels> find something you enjoy <carlos> seb128: do we have any GNOME package in hoary/warty that uses cdbs and adds new strings to the orig.tar.gz? <ChrisH> So there is not the classical way to first maintain packages (as there are hardly any ubuntu-specific packages) and the look further... <seb128> carlos: add new strings ? gnome-panel ? <carlos> seb128: only gnome-panel? <carlos> seb128: does it uses cdbs? <seb128> probably yes <seb128> yes, cdbs <carlos> ok, thanks <seb128> np <fabbione> ChrisH: if you like to maintain packages you can do that <fabbione> ChrisH: it's all up to you <mojo> hi all ppl <mojo> does anyone here encounter a problem with wheeling mouse scroll on Ubuntu Bugzilla? <fabbione> mojo: yes <ChrisH> fabbione: I'm just used to just maintain packages. Everything else needed discussions on mailing lists I rather not read to keep my blood-pressure low. So "freedom of choice" for developers/contributors/maintainers is a new concept to me. :) <mojo> You can wheel scroll for around 10 lines then I stuck <ross> mojo: if the cursor is over a text area it will scroll that instead <fabbione> ross: it does indipendently from where you scroll <fabbione> i did check several combination <mojo> yeah <mojo> I think it's a bug of Ubuntu Bugzilla <ross> interesting, not seen that <mojo> I tried to test with other website <mojo> it only happens with Ubuntu Bugzilla <seb128> yes, I've this problem too <fabbione> ChrisH: well.. some topics will have to be discussed here too :-) <thom> mojo: it's a firefox bug <thom> mojo: and it's already filed <thom> both upstream and in ubuntu <fabbione> thom: also in mozilla <thom> fabbione: same odds <fabbione> :-) <daniels> thom: have you fixed it yet? :) <thom> daniels: nope <seb128> thom: I need a "firefox-gtkmozembed" to build epiphany with firefox, where do you hide this file ? <seb128> thom: same for firefox-xpcom <daniels> thom: Package: mozilla-firefox Subject: have to restart it when you upgrade it Severity: blocker Assignee: [email protected] <seb128> thoooooom <thom> seb128: looking <daniels> seb128: (i think we broke our tourguide) <thom> guess they're not installed <thom> daniels: bite me <seb128> thom: we need a mozilla-firefox-dev * fabbione upgrades to hoary and X.org <thom> seb128: yeah <thom> looking at how much work this will be <seb128> thom: do you need a bugzilla entry as a reminder ? <thom> seb128: please <Mithrandir> I dreamt up an idea for transitioning to dependency-based init tonight <Mithrandir> what we know today is that the ordering is correct, so we know that services starting at step 20 might need anything loaded before. <Mithrandir> so we already have a worst-case ordering-graph today. <daniels> bear in mind gdm will be moving today or tomorrow <daniels> just to throw you all into confusion <Mithrandir> a service could then add some meta information about what other services it needs to have running, and there wouldn't be any need for a full transition. <Mithrandir> legacy applications would still use the ordering system, and everybody would be happy. <seb128> thom: done <fabbione> 700 upgraded, 33 newly installed, 7 to remove and 0 not upgraded. <fabbione> Need to get 0B/492MB of archives. <fabbione> After unpacking 59.2MB of additional disk space will be used. <thom> seb128: danke <fabbione> warty to hoary+x.org <seb128> np <bob2> hm, last I tried gnome-devel wasn't installable in hoary <lamont> bob2: I think that's the gnutls 10->11 transition thang <seb128> it works here
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ICollection<BEncodedValue> Values { get { return this.dictionary.Values; } } public IEnumerator<KeyValuePair<BEncodedString, BEncodedValue>> GetEnumerator() { return this.dictionary.GetEnumerator(); } System.Collections.IEnumerator System.Collections.IEnumerable.GetEnumerator() { return this.dictionary.GetEnumerator(); } #endregion } }Q: Class property — filling by Extension method while the Property is null I have: public class NameClass { public NameClass(){} string Name {get; set;} bool IsValid {get; set;} } public class Person { public Person() {} public NameClass Name {get; set;} } an extension method: public static void FillIt(this NameClass c, string name) { if (c == null) { c = new NameClass(); } if (string.IsNullOrEmpty(name) == false) { c.IsValid = true; } c.Name = name; } then there is a void to create Person instance: private void CreateMyPerson() { Person p = new Person(); p.Name.FillIt(txtName.Text); if (p.Name == null) Response.Write("Ooops, PROBLEM!"); // checking for filled p.Name - IT IS STILL null - WHY? } Googling didn't help me, I'm not native english speaker, maybe i can't ask uncle Google well. Using extension method to fill the property seemed to me the most elegant way to assign it a value, but although in the extension method the "c" variable seems to be initialized and set fine, later when checking if p.Name is null - it turns that it is not set... Any clues? A: When you do this: c = new NameClass(); You're not assigning an instance of NameClass to the property on the Person object. You're assigning it to the local variable c. Once that assignment is made, that local variable no longer has anything to do with the reference to the property on the Person class. If you always want Name to be initialized, do it in the Person constructor: public Person() { this.Name = new NameClass(); } Then your extension method doesn't need to check for null in the first place: public static void FillIt(this NameClass c, string name) { if (string.IsNullOrEmpty(name) == false) { c.IsValid = true; } c.Name = name; } Since c is never re-assigned in this version, it still points at the property on the Person object. Though depending on what you're trying to accomplish here, do you even need this extension method at all? If it's required that a Person has a name, you can require that on the Person constructor. And/or on the NameClass constructor. Initializing an object and then checking that it's valid is two steps, but requiring it to be valid when initializing it makes it only one step. If an "invalid" object shouldn't be allowed, simply don't allow it. A: p.Name is a reference type variable which points to null. Calling FillIt method copies value of p.Name (which is null) to reference variable c. So, in fact there is no link between variable c and p.Name and any kind of manipulation on variable c is local. On the other hand, if p.Name is not null and refers to memory address, lets say 0x1111, then calling extension method would copy that address to variable c and manipulation on c would affect p.Name also, since they both refer to same memory address. MINGORA, Pakistan – Pakistani police have arrested a number of suspects in the case of a 14-year-old girl shot and wounded by the Taliban for promoting education for girls and criticizing the fundamentalist Islamic movement, officials said Friday. The shooting of Malala Yousufzai along with two classmates while they were on their way home from school Tuesday horrified people in Pakistan and internationally. It has been followed by an outpouring of support for a girl who earned the enmity of the Taliban for publicizing their acts and speaking about the importance of education for girls. The Taliban have claimed responsibility for the shooting, saying that the girl was promoting “Western thinking.” Late on Thursday, a spokesman for one of the group’s branches in the country’s north said the top leadership of the Taliban’s Swat Valley chapter decided two months ago to kill Yousufzai in a carefully planned attack after her family ignored repeated warnings. Police have been questioning people in the town of Mingora, in the Swat Valley, where the shooting took place. Mingora police chief Afzal Khan Afridi said arrests had been made, but he declined to give any details about the number of people detained or what role they’re suspected of having in the shooting. He said he did not want to endanger the ongoing investigation. Interior Minister Rehman Malik told reporters Friday that the two gunmen who staged the attack were not among those arrested, but he said investigators had identified the masterminds of the shooting and efforts were under way to capture all those involved. The Taliban spokesman, Sirajuddin Ahmad, said Yousufzai’s family had been warned three times – the most recent warning coming last week – before the decision was made to kill her.Associations of body mass index and obesity with physical activity, food choices, alcohol intake, and smoking in the 1982-1997 FINRISK Studies. Recent increases in the prevalence of obesity worldwide are suggested to be caused largely by an environment that promotes sedentariness and excessive food intake. We investigated associations of body mass index (BMI) and obesity with physical activity, food choices, alcohol consumption, and smoking history. In addition, we examined the consistency of these associations over time, with the aim of assessing whether the significance of lifestyle variables as correlates of obesity increased over a 15-y period. Independent cross-sectional surveys were carried out in 1982, 1987, 1992, and 1997. Altogether, 24604 randomly selected men and women (aged 25-64 y) participated in these surveys. The subjects' weights and heights were measured, and data on lifestyle were collected with self-administered questionnaires. In men and women, perceived general health, leisure-time physical activity, and daily vegetable consumption were inversely associated with obesity, as were bread consumption in women and activity at work in men. Consumption of sausages, milk, and sour milk and heavy work (in women only) were positively associated with obesity. Obesity was also associated with alcohol consumption and smoking history. Most associations were constant over the 15-y period. However, the inverse associations of BMI with physical activity in women and with perceived health in men seemed to strengthen over time. A physically active lifestyle with abstention from smoking, moderate alcohol consumption, and consumption of healthy foods maximizes the chances of having a normal weight. The significance of avoiding sedentariness increases over time as a factor associated with normal weight.Saturday, 5 May 2007 Cinco de Mayo In English, 5th of May. Cinco de Mayo is a national, but not federal, holiday in Mexico. It commemorates the victory of Mexican forces led by General Ignacio Zaragoza Seguin over the French occupational forces in the Battle of Puebla on May 5, 1862. Although the Mexican army was eventually defeated, the "Batalla de Puebla" came to represent a symbol of Mexican unity and patriotism. With this victory, Mexico demonstrated to the world that they were willing to defend themselves against any foreign intervention, especially those from imperialist states bent on world conquest. In these terms, we should join our brothers and sisters in their celebration. Freedom is a precious reality, generally best understood when it doesn't exist. God's plan is for all to be free, no matter what oppression is attempting to control us. Look to Him today for this miracle. John 8:36 (NIV) 36 So if the Son sets you free, you will be free indeed.using System; using System.Collections.Generic; using System.Linq; using System.Text; using System.Threading.Tasks; namespace ZFS.Model.RequestModel { public class BasePaging { public int pageIndex { get; set; } public int pageSize { get; set; } } public class BaseTime { public DateTime startTime { get; set; } public DateTime endTime { get; set; } } } [An experimental observation of repair after transection of cauda equina fibers in cat]. To explore the regeneration characteristics after cauda equina transection. Fibrin glue was chosen to repair transected left L6,7 roots in cat, and right roots in situ of the transected ends were served as the control. The characteristics of regeneration were observed by immunohistocytochemistry and morphometric analysis. Regeneration was found not only in site of anastomosis, but also
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man whose life had been in his hands that winter morning was, in all likelihood, her brother.... Suddenly she found herself thinking about a situation she had once been in with a diver whose skill and competence she had misjudged. The man had ended up wedged in a narrow tunnel with his air supply all but used up. Luckily, she had sensed trouble and located him just a minute or two from disaster. She was able to buddy-breathe him up to the surface, but the outcome could easily have gone the other way. She wondered how her life would have changed, how she would have responded had he not made it out of that tunnel alive. The manager of her club, people diving with her day after day—they had no more interest in seeing her as human, as fallible, than she did Eric. When she finally turned back to him, tears glistened in her eyes. "I wish you hadn't stopped trying," she said. "I know. I wish like hell I could have that morning back. Believe me I do. And I know it doesn't help Scott, but I'm determined never to make judgments on the value of anyone's life again." "And never to ignore the possibility that what seems ordinary may not be at all?" "That too." She put her arms around him and touched her lips to his ear. "Fair enough," she whispered. "There it is, pal. Beautiful Cleveland, Ohio." Eddie Garcia swigged down the last of a thermos of coffee and wiped his mouth with the back of his hand. He was glad to be nearing the end of the run but was anxious about his passenger. Soon, he would have to drop Bob off, point him in the direction of the bus terminal, and go about unloading his rig. The man was no more prepared or equipped to strike out on his own than a kindergartener. For a time during their journey, Eddie had tried to help him remember something, anything. But beyond recurring references to East Boston, a woman named Gideon, and her horse, he got nowhere. He pressed questions about Bob's limp and about his hand; he asked about his family, his service record. Nothing. Not even a glimmer. It was as if a razor had sliced cleanly through all connections to his past. For a while, Eddie even gave thought to driving him to Boston. But with a perfect turnaround run awaiting him in Cincinnati, that possibility was out of the question. He guided the semi off the interstate and began working his way through darkened, successively narrowing streets toward Buckeye Packing. It was three in the morning, an hour before he was due in. He didn't know his way around the city at all, but there was a bit of time to look for a diner. If they found one, he would spring for one last meal, give Bob thirty or forty bucks, find out directions to the bus terminal, and send him on his way. That was more than most anyone else would be doing in a similar spot. Bob himself, after sleeping through most of Indiana and Ohio, had awakened just outside of Lorain, and was once more staring out the window. If there were any thoughts going on in his mind, he showed no sign of them. But Eddie could still sense the aura of sadness and bewilderment enveloping him. "You feelin' okay?" Eddie asked. "Uh-huh." "Good, because you've got some travelin' ahead of you. Boston is still a hell of a ways." Scott squinted at the passing lights and strained to put together the images swirling through his mind. Nothing connected. Nothing at all. They turned onto a side street barely wide enough for the rig, and rolled into a broad, deserted flat lined with warehouses and factories. "Buckeye Packing's just up this road," Eddie said. "That's good," Scott said with no emotion. "I thought we might cruise around and see if we can find us some breakfast." Eddie had slowed to less than ten miles per hour when he saw a man standing in the road ahead, waving a stop sign at them. He was dressed in work clothes and a plaid hunting overshirt. Garcia brought the semi to a stop and rolled down the window. "Mornin'," he said. "What's up?" The man, husky, with close-cropped hair, walked to the window, pulled a revolver from his waistband, and held it two feet from Eddie's face. "Open the door," he growled. "No sudden moves." A second man, brandishing a shotgun, appeared by the passenger door, and a third stepped just in front of them. "Hey, wait a minute," Eddie said. "I'm just hauling beef. There's nothing of any—" "We know what you have," the man said. "Now just get out or you're dead." Eddie turned to his passenger. "Bob," he said evenly, "we're being hijacked. Just open your door and do what these fuckers say. Without this rig and this load, I'm busted, but I don't know what the fuck else we can do, goddam it." Slowly, the two of them opened their doors and dropped to the pavement. The man who had stopped them, clearly the leader of the three, motioned them together and then pointed to an alley between buildings. "In there," he ordered. "Do as I say and neither of you gets hurt." "Hey, look," one of the others said. "This guy's a gimp. What are you, some kind of war hero?" Scott merely looked at him. "Do what the man says, Bob," Eddie whispered. "Hey guys, please. This rig's all I have." "In the alley," the man barked. For Eddie Garcia, the half-minute or so that followed was little more than a blur. It began with Bob bending over, ostensibly to tie his shoe. Suddenly, and with vicious force, he swung his arm backhand, catching one of the hijackers across the throat, and dropping him like a stone. In virtually the same motion, he whipped his good leg around, sweeping the second man to the ground and stunning him with a glancing right, palm up under his chin. The shotgun clattered to the pavement, but the man, not immobilized, lashed out with his feet, knocking Bob over. The leader of the group, a beat slow to react, was raising his revolver when Eddie kicked him in the groin. The man doubled over as Eddie kicked him again, catching him on the upper arm and sending him sprawling. To Garcia's left, the first man hit was stumbling to his feet while the second had grabbed Bob by the throat and was beginning to pummel him. In that instant, Eddie saw the look on his passenger's face. It was an expression he would never forget as long as he lived—not one of panic or rage or fear, and certainly not the blank stare he had grown so used to over the miles. Rather, Bob appeared almost serene, removed from what was happening to him, oblivious to the pain. He seemed to be completely ignoring the man on top of him in order to focus in on something else. Before Eddie realized what was happening, Bob had reached out with his good leg and swept the shotgun several feet in his direction. Eddie dived for it, rolling over and over again as he fumbled to cock it. One hijacker had already started to run. The second, realizing what had happened, shoved Bob aside, kicked him hard in the ribs, and was racing toward the alley as Garcia fired. The shot seemed to hit him, but after staggering a step, he barreled on. Moments later, he disappeared into the alley. By the time Eddie brought the shotgun around, the man he had kicked was up and sprinting away. He leveled and fired, but the hijacker was already well out of range. In seconds, the street was quiet again. Shaken and gasping for breath, Eddie stumbled to his feet. Bob was on his knees, holding his left side. "You okay, Bob?" Garcia asked. Scott coughed and felt the searing clinch of broken bone in his chest. He had had fractured ribs before, he knew. But when? And how? "I'm okay," he managed. Garcia helped him to his feet. "You sure?" he asked. "You want to go to a hospital?" The word brought a barrage of images to Scott's mind, none of them pleasant. "No," he said hoarsely. "No hospital." Eddie Garcia stepped back a pace and looked at him. "I've never seen anyone move like that," he said. "Who are you?" Scott looked at him sadly and shook his head. "I don't know, Eddie. I don't know anything. I didn't even plan on attacking those guys. It just happened." He coughed again, and had to splint the pain to keep from passing out. "I'm takin' you to a fuckin' hospital," Garcia insisted. Scott shook his head. "I've got to get to East Boston," he said. "It's important."
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-mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=120 KB=63 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.749960e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=120 KB=64 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.904721e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=168 KB=65 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.788716e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=168 KB=66 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.941401e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=144 KB=67 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.849532e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=144 KB=68 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.996540e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=168 KB=69 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.890309e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=168 KB=70 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-1.003061e+05 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=168 KB=71 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.804842e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=168 KB=72 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.948134e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=144 KB=73 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-9.981667e+04 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=144 KB=74 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-1.011840e+05 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=168 KB=75 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-1.001908e+05 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=8 KU=2 NU=4 MU=24 MB=48 NB=168 KB=76 AOUTER=1 KRUNTIME=1 \ LDCTOP=1 \ MFLOP=-1.014878e+05 ASM=GAS_x8664 \ CFLAGS='-x assembler-with-cpp -mavx -mfma' COMP='gcc' ID=25 ROUT='ATL_samm24x4x2_fma3.S' AUTH='R. Clint Whaley' TA='T' TB='N' \ OPMV=13 VLEN=
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a niche digital asset as a national currency. In true fake news style, the article reads, “It’s finally happened. A major worldwide government has just bestowed a huge vote of confidence and legitimacy onto the world of cryptocurrencies. Sweden, in an unprecedented move, just announced that they are officially adopting a certain cryptocurrency as Sweden’s official coin!&… This article appeared first on Cryptovest Like this: Like Loading...Beautiful Vintage Annuals for Children In the late 1800s, children's stories were published in periodicals and distributed weekly or monthly to readers. To further capitalise on their market, publishing houses put together annuals filled with the best stories, illustrations and games from the year. The book was released for Christmas, and marketed as the perfect gift (both entertaining and educational) for children. The annuals were generally distributed in Britain and its colonies such as Canada and Australia, although sometimes also in the United States. These vintage annuals are usually large, hardcover books with at least 200 pages and illustrations both in colour, and black and white. Their bright cover art is filled with eye-catching art. At the turn of the century publishers began to include new, unpublished stories in order to boost sales. Often notable authors like W.E. Johns, Enid Blyton, Angela Brazil, E. Nesbit and P.G. Wodehouse were among the contributors. Each annual had a specific market - girls, or boys, girls and boys, or a certain genre like a cinema club. Today's equivalent is a teen magazine, or a periodical for a celebrity or band. Popularity grew through the early 1900s and in turn production increased. Everyone wanted a share of the market, from Mickey Mouse to Japhet & Happy, The Rainbow, Tiger Tim, Sparky and Rupert's Daily Express. During World War II, paper rationing affected the quality and amount of books published and by 1950 many ceased production. Children were drawn to other sorts of media like comics and TV. Today vintage annuals are collectable. These books were intended to be coloured in, written on, read, discussed and coveted, so copies in fine condition are scarce. You can expect to pay between £30 and £300 for an attractive copy. Related Video Blackie's Children's Annual Blackie and Son Limited was a publishing house in Glasgow. They began publishing in 1891, and closed their doors in 1991. ›See the books Nister's Holiday Annual Earnest Nister's books were known for their whimsical, exquisite and beautiful images and movable parts. Though he only produced books in the 1890s, he was able to create a wide array of children's literature. ›See the books The Boys and Girls Cinema Clubs Annual A popular annual in the 1940s and '50s when many children belonged to cinema clubs. It focused mainly on films for children and club activities, but also showcased blockbusters. ›See the books Daily Mail Annual Published by the Daily Mail newspaper, this annual contained cartoons, verses, puzzles and stories for children. Enid Blyton and W.E. Johns were among the contributors and editors of this series. ›See the books The Girl's Own Annual The Girls Own was a weekly (later monthly) publication for young girls and teens. The Annual was published from 1880 to 1940 and offers great insight into British middle class life during that time. ›See the books The Greyfriars Holiday Annual This annual had mostly new stories about a fictional school called Greyfriars created for a boys paper called The Magnet. It ran from yearly from 1920 until 1941. ›See the books The Modern Boy's Annual This publication contained new Biggles adventures by W.E. Johns plus other stories, information, supplements and pictures that would be of interest to boys during the 1930s and '40s. ›See the books Puck Annual A lavishly illustrated annual filled with short stories for boys and girls from the 1920s and '30s. ›See the books Father Tuck's Annual Published from 1897 to 1931, Father Tuck's Annual was filled with poems, short stories, music and full colour illustrations teaching lessons such as good children get rewarded and bad children will be punished. ›See the books Once Upon a Time Annual Filled with illustrations, games, puzzles and stories for girls and boys. ›See the books/** * Copyright Amazon.com, Inc. or its affiliates. All Rights Reserved. * SPDX-License-Identifier: Apache-2.0. */ #pragma once #include <aws/chime/Chime_EXPORTS.h> namespace Aws { namespace Utils { namespace Json { class JsonValue; class JsonView; } // namespace Json } // namespace Utils namespace Chime { namespace Model { /** * <p>The logging configuration associated with an Amazon Chime Voice Connector. * Specifies whether SIP message logs are enabled for sending to Amazon CloudWatch * Logs.</p><p><h3>See Also:</h3> <a * href="http://docs.aws.amazon.com/goto/WebAPI/chime-2018-05-01/LoggingConfiguration">AWS * API Reference</a></p> */ class AWS_CHIME_API LoggingConfiguration { public: LoggingConfiguration(); LoggingConfiguration(Aws::Utils::Json::JsonView jsonValue); LoggingConfiguration& operator=(Aws::Utils::Json::JsonView jsonValue); Aws::Utils::Json::JsonValue Jsonize() const; /** * <p>When true, enables SIP message logs for sending to Amazon CloudWatch * Logs.</p> */ inline bool GetEnableSIPLogs() const{ return m_enableSIPLogs; } /** * <p>When true, enables SIP message logs for sending to Amazon CloudWatch * Logs.</p> */ inline bool EnableSIPLogsHasBeenSet() const { return m_enableSIPLogsHasBeenSet; } /** * <p>When true, enables SIP message logs for sending to Amazon CloudWatch * Logs.</p> */ inline void SetEnableSIPLogs(bool value) { m_enableSIPLogsHasBeenSet = true; m_enableSIPLogs = value; } /** * <p>When true, enables SIP message logs for sending to Amazon CloudWatch * Logs.</p> */ inline LoggingConfiguration& WithEnableSIPLogs(bool value) { SetEnableSIPLogs(value); return *this;} private: bool m_enableSIPLogs; bool m_enableSIPLogsHasBeenSet; }; } // namespace Model } // namespace Chime } // namespace Aws Low Ca(2+) pump activity in diabetic nephropathy. Elevated cell Na(+)-H(+) exchange (NHE) activity characterizes diabetic nephropathy (DN), but the mechanisms of this abnormality are unclear. Recent evidence suggests that NHE and the Ca(2+) pump share similar regulatory pathways, but whether abnormalities in Ca(2+) metabolism characterize DN is not known. We investigated Ca(2+) efflux rates, NHE activity, cytosolic Ca(2+) ([Ca(2+)](i)) concentrations, and intracellular pH (pH(i)) in human skin fibroblasts from 20 patients with type 1 (insulin-dependent) diabetes and nephropathy; 20 patients with diabetes with normoalbuminuria matched for age, sex, and duration of diabetes; and 10 individuals without diabetes. Ca(2+) pump-mediated Ca(2+) efflux was significantly lower in patients with nephropathy than in patients with normoalbuminuria and individuals without diabetes (0.074 +/- 0.01 versus 0.115 +/- 0.01 versus 0.131 +/- 0.02 nmol.mg(protein)(-1).min(-1); analysis of variance [ANOVA], P = 0.015). Elevated maximal velocity of the Na(+)-H(+) exchanger was confirmed in fibroblasts from patients with nephropathy (14.4 +/- 1.2 versus 7.1 +/- 0.7 versus 8.0 +/- 1.2 mmol H(+).l cell(-1).min(-1); ANOVA, P < 0.0001). A reverse correlation between Ca(2+) pump activity and NHE rates could be shown. Adjustment for glycated hemoglobin and plasma lipid levels did not affect these findings. Finally, [Ca(2+)](i) concentrations and pH(i) were normal in all patients. Low Ca(2+) pump activity is a concomitant event of elevated NHE rates in DN; the molecular dysfunction(s) underlying these abnormalities remains to be established.Area residents have mixed reactions to gay marriage rulings KINGSPORT — Area residents took to social media Wednesday to voice mixed reaction to the U.S. Supreme Court’s rulings regarding gay marriage. By 9 p.m. six dozen comments about the issue had been left on the Kingsport Times-News Facebook page (Times-News Online). They ran the gam
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2d at 1030. Therefore, there is an issue of fact whether the Board's refusal to accept Caloumeno's post-hearing brief denied him a full and fair hearing. Because there are issues of fact going to Caloumeno's fair hearing claims, the parties' motions for summary judgment on the first cause of action are denied. c. Breach of Contract Claims The complaint's seventh cause of action is for breach of contract. Caloumeno considers the CSEA constitution and by-laws to be a contract. As we indicated above and in our memorandum decision of July 15, 1985, "[t]he provisions of the LMRDA were not intended by Congress to constitute an invitation to the courts to intervene at will in the internal affairs of unions." Gurton v. Arons, 339 F.2d 371, 375 (2d Cir.1964). The union itself is the proper forum to resolve this [contractual] dispute. Indeed, an important function of any union Judicial Board is to enforce the provisions of the union's constitution and bylaws; this function would be emasculated were we to permit the [assertion of this claim]. Caloumeno, No. 83 Civ. 4932, slip op. at 15 (S.D.N.Y. Jul. 15, 1985). Therefore Caloumeno's breach of contract claims do not, per se, state a claim under the LMRDA. However, Caloumeno asserts that his breach of contract claim is not one brought under the LMRDA, but rather is an ancillary state claim, over which we have pendent jurisdiction. In light of the questions discussed above concerning Caloumeno's allegations of breach, this rather questionable claim is not ripe for decision. d. LMRDA Free Speech Claims Section 101(a)(2) of the LMRDA, 29 U.S.C. § 411(a)(2) (1982), guarantees members freedom of speech and assembly in union affairs. This guarantee creates a tension with other statutes and policies. See, e.g., Schonfeld v. Penza, 477 F.2d 899, 903-904 (2d Cir.1973) (Title IV's requirement of initial appeal to the Secretary of Labor); Newman v. Local 1101, Communications Workers of America, A.F.L.-C. I.O., 570 F.2d 439 (2d Cir.1978) (longstanding policy against intervention in the internal affairs of unions). In order to accommodate the competing objectives underlying these various constraints, the courts will intervene under section 101(a)(2) only "where union action ... can be fairly said, as a result of established union history or articulated policy, to be part of a purposeful and deliberate attempt by union officials to suppress dissent within the union." Schonfeld, 477 F.2d 809, 904 (2d Cir.1973); see also Newman, 570 F.2d at 445-446. This standard is not met by the "mere appendage of free speech allegations to an *328 election complaint," Schonfeld, 477 F.2d at 903, but rather requires clear and convincing proof. Newman, 570 F.2d at 445-446. The question of whether the union's actions in question were taken for the purpose of stifling dissent or simply to discipline perceived thievery, raises issues of motivation and intent. Such "state of mind" issues are ordinarily inappropriate subjects for summary judgment treatment. 10A Wright, Miller & Kane, Federal Practice and Procedure: § 2730 (1983). Moreover, there is an issue of fact whether the union's disciplining of Caloumeno was an isolated retaliatory action, or part of a wider anti-democratic scheme. For this reason also, summary judgment on Caloumeno's LMRDA free speech claims is inappropriate. Cotter v. Owens, 753 F.2d 223 (2d Cir.1985). e. LMRDA Equal Rights Claims The viability of Caloumeno's LMRDA equal rights claims depends on that of his LMRDA free speech and fair hearing claims. Because we have denied summary judgment on the latter claims, we must perforce deny summary judgment on the equal rights claims. CONCLUSION For the reasons discussed above, the remaining claims in this action are those numbered 1, 2, 3, 4, 5, 7, 11, and 17. As to these claims, the parties' several motions for summary judgment are denied. In closing, we wish to remark that this Court has been attempting to bring this case on for trial for several years. However, counsel for both parties have preferred to conduct extensive motion practice. This must cease. The parties must be ready for trial within thirty days of the date of this decision. SO ORDERED. NOTES [1] The twenty-ninth claim pertains to the LMRDA free speech rights of Dennis Tobin. However, both the plaintiffs and the defendants have acknowledged that Tobin has withdrawn as a plaintiff in this action. See Plaintiffs' Reply Memorandum (in opposition to defendants' earlier motion to add Local 350 as a party) at 14; Affidavit of Michael J. Smith in Support of Defendants' Motion for Summary Judgment at ¶ 7. Indeed Tobin is a counterclaim plaintiff. Accordingly, the twenty-ninth claim is dismissed. [2] Caloumeno has conceded the invalidity of the sixth claim. Caloumeno v. McGowan, No. 83 Civ. 4932, slip op. at 9, n. 3 (S.D.N.Y. Jan. 9, 1984). In addition, the eighth and ninth "claims" concern remedies and are not separate causes of action per se. Id. [3] Caloumeno also argues that he was denied a fair hearing because the Board refused to approve a settlement offered by both parties. This point is frivolous and does not merit discussion. [4] Caloumeno argues that the Judicial Board Procedures gave him the right as President of Region II to demand that his hearing be held in New York City. These Procedures provide that absent special circumstances, hearings "will" be held at the CSEA headquarters in Albany "or in Region offices." It is not clear, however, to whose discretion is left the decision as to the actual location of a given hearing, whether Albany or a Region office. Nor is it clear on what factors such a decision should rest. [5] Neither party's submissions include a copy of the brief in question. We are therefore not in a position to comment on whether it was of any consequence. Q: Get textbox.Text from FORM to CLASS I have tried to get the textbox.text to a class and it doesent work what am I am doing wrong please help! In my form.cs it looks like this: public string score1; public void getPlayerOneScore1Input() { score1 = playerOneScore1TextBox.Text; } public void playerOneAddScoreButton_Click(object sender, EventArgs e) { score1Calculator theCalculator = new score1Calculator(score1); } and in my CLASS it looks like this: class score1Calculator { public score1Calculator(string score1) { this.score1= score1; } public int playerOneDart1Value; public void calculateDart1() { if (score1== "t1" || score1== "T1" || score1== "3") { playerOneDart1Value = 3; } else { MessageBox.Show("Dart 1! This is not a valid input!"); return; } } } error i get: 'WindowsFormApplication1.score1Calculator' does not contain a definition for 'player' and no extension method 'player' accepting a first argument of type 'WindowsFormApplication1.score1Calculator' could be found (are you missing a using directive or an assembly reference?) A: There is no need to do it overly complicated. A Textbox.Text value is just a string. You can directly call the constructor with this reference. Just write it like this score1Calculator theCalculator = new dart1Calculator(playerOneScore1TextBox.Text); No need to store the value on module level. As is known in the art, a radio frequency (RF) transmitter is a device that produces RF signals. RF transmitters may be included, for example, as part of a radio communication system that uses electromagnetic waves (radio waves) to transport information over a distance. As is also known, a trade-off must generally be made in RF communications transmitters between energy efficiency and linearity. Over the decades of development of the RF transmitter and corresponding RF amplifiers, it has generally been true that one could obtain either high efficiency or high linearity, but not both. It would, therefore, be desirable to provide systems and techniques that avow a user to amplify RF signals and/or transmit data carrying RF signals with both high efficiency and high linearity. Fading Out... By Ayush Srivastava 2014 Copyright Ayush Srivastava Smashwords Edition Smashwords Edition, License Notes Thank you for downloading this ebook. This book remains the copyrighted property of the author
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." "[loud music playing] -[crowd cheering]" "[Tony] I'm bringing a mirror." "I'm bringing crazy tools." "I mean, I'll be off the charts." "I'll be weird." "I'll be bizarre." "I'll seem gross." "I'll use the science of taboo language because words have the power to pierce the conscious mind." "Look, I'll do whatever the eff it takes to break the pattern, so you can reclaim who you really are." "[announcer] Welcome to the stage, Mr. Anthony Robbins!" "[crowd cheering]" "[singing] ♪ Life will never be the same ♪" "Whoa!" "Come on, guys!" "Come on!" "Come on!" "Whoa!" "How're you doing out there, ladies and gentlemen?" "[crowd cheering]" "Welcome to "Date With Destiny 2014," and for some of you, welcome home." "Good to see you." "Start your morning" " It's afternoon now, with 12 good morning high-fives, hugs." "Go for it." "Introduce yourselves." "Connect." "All right, grab a seat." "Thank you for the warm welcome." "What have you gotten yourself into?" "[chuckles] [audience cheering]" "I wanna welcome you here." "First of all, this is my favorite program." "This is my 74th "Date With Destiny" in 25 years." "It's been amazing." "And over those decades, doing this, literally, all around the world in virtually every major country." "I've had people from more than 100 countries attend this program." "Uh, what I can tell you right now is this program is different than any other program." "And what's different about this program is not only the depth of what we're gonna go to." "We're gonna get to take a look at the force that controls every thought, every feeling and every emotion of your life." "The beliefs, values, and rules that literally control the way you think, feel, and behave." "We are gonna get emotionally fit because life is gonna come at you." "This is not some bullshit "positive-thinking" seminar where I'm gonna tell you to start chanting," ""There's no weeds, there's no weeds," and hope shit isn't there." "This is a place where you and I prepare for anything." "We look for the weed and we rip it out." "Over the next six days and nights, we're gonna get to the source of what controls it all, then you're gonna change it." "And you're not going to do it the way I tell you to." "Who the hell am I?" "I'm not your guru." "I didn't come here to fix you 'cause you're not broken, and I know that." "Even if you think you're broken, I'm here to tell you and show you you're not." "What I want you to know is if you're gonna have a breakthrough, when someone says, "It took ten years to make a change,"" "what you really find out is that change happened in a moment." "It took you ten years to get to the moment where you finally said," ""Never again!" "I quit!" "Let's begin!" "I love you!" "I do!" "It's over!"" "Our entire life changes in a moment." "Who gets that?" "Say "aye."" "[all] Aye!" "And I want you to get that what we're gonna do is have lots of those moments." "And you can have as many as you want." "There's no limit here." "You can break through multiple times." "Guys can even have multiple breakthroughs." "It's an amazing thing." "[audience laughing]" "It's truly amazing." "By the way, how many of you came here because there's something significant you really wanna change in your life right now?" "How many came-- 'Cause that's a major outcome." "Say "aye."" "[all] Aye!" "We're gonna make sure you get that change, but that's temporary." "What we really want to do is not just solve your problem... but deal with the thing that creates it in the first place." "That's what's gonna be mind-boggling in its change." "But for it to work, we gotta be energy-rich." "And I know you won't always feel that way." "I won't either." "But that's part of the discipline of someone who's the best in the world at what they do." "I'm inviting you right now to make a decision." "That for the next six days" "You could do anything for six days and nights, couldn't you?" "For the next six days, you play a level of intensity you've never played before." "You push yourself." "You use your voice, your body to keep finding a way to increase that energy." "Because at that energy level, you'll get totally different insights than at the one most people live in day-to-day." "And they go, "I get it." "I understand." "I do."" "But if you and I wake up, we could take back control forever." "You're gonna watch people stand up in the next few days and they're gonna reclaim their life." "They're gonna wake up." "And that's where the game gets exciting." "Who knows what I'm talking about here?" "Say "aye."" "[all] Aye!" "Good." "So now... what's an area that you came here with that it's time to break through?" "What's an area of your life that is not the way you want it?" "Who's got something of that nature?" "Yes, ma'am." "Give her a hand." "[audience applauding]" "Give her a hand!" "[audience cheering]" "What's your name?" "Where're you from?" "Sienna." "I'm from Newport Beach, California." "Sienna." "Give her a hand." "It's Sienna, ladies and gentlemen." "So, Sienna, what is it you're frustrated with?" "What is it that's not where you want it to be?" "Uh, my diet." "Your diet." "And what about your diet?" "Um, not that it has to be perfect, but that I know that my body and my health deserve better." "Okay." "And better than what?" "Like, what are you not doing that you should be doing?" "I'm not eating at the times of the day I should be..." "that would be most beneficial for me." "Okay." "Okay." "And it's making myself lose respect." "Lose respect for yourself?" "Yes." "Okay, and when you lose respect for yourself, what do you do?" "I then eat. [laughs]" "It's in a whole fun circle." "Yes." "Yeah. [chuckles]" "And now, question." "What are you doing all this for?" "What's life about?" "It's about finding love and happiness." "Okay, so life is about finding love and happiness, okay?" "And what has to happen for you to hit the target of love and happiness?" "[Sienna] Um... do something kind for others." "So you gotta do something kind for others." "Do something for myself that, um, scares me, that's new." ""Do something for myself that scares me."" "So here's this young lady, "Life's about love and happiness," "I gotta do kind for other people." "I gotta do something that scares me."" "What else do I need to do?" "I need to give love to those who don't have it." "Okay. "I need to give love to those who don't have it." Fantastic." "What else do I need to do?" "I need to receive love." "And what do you have to do to receive love?" "Do you have to be worthy of it?" "Yes." "And what has to happen for you to be worthy of receiving love?" "I have to be responsible for their happiness." ""I have to be responsible for their happiness."" "Now, fortunately, she's only how old?" "Nineteen." "Nineteen." "So she hasn't felt the wear and tear of a couple decades of that yet." "[chuckles]" "To wear her into the fucking ground." "Who knows what I'm talking about here?" "[chuckles]" "Say "aye." -[all] Aye!" "We're seeing her right before all the fucking shit happens right now." "Isn't this cool?" "All right." "[audience laughing]" "Now let's take a look at something for a moment." "This is where your model of the world has come from, the thing that's controlling all your decisions." "Whose love did you crave the most growing up?" "Your mother or your father?" "Not "who did you love more?" I'm sure you loved them both." "Whose love did you crave more?" "Truthfully." "Since I didn't quite get it, it was my dad's." "Yes, clearly." "Who did you have to be for your father?" "First reaction." "My gosh." "Phew." "Now, I'm really on her right now." "She's doing some real honest searching." "Can you feel that?" "[audience] Yeah." "She didn't like this, you see that?" "She liked that whole thing when," ""I know what to say, know what to do, and I can achieve it all
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ICO, also known as Javi, Defendant-Appellant Appeal from the United States District Court for the Eastern District of Texas USDC No. 4:16-CR-11-10 Before DAVIS, JONES, and DUNCAN, Circuit Judges. PER CURIAM: * The attorney appointed to represent David Javier Rico has moved for leave to withdraw and has filed a brief in accordance with Anders v. California, 386 U.S. 738 (1967), and United States v. Flores, 632 F.3d 229 (5th Cir. 2011). Rico has not filed a response. We have reviewed counsel’s brief and the relevant portions of the record reflected therein. We concur with counsel’s assessment that the appeal presents no nonfrivolous issue for appellate review. * Pursuant to 5TH CIR. R. 47.5, the court has determined that this opinion should not be published and is not precedent except under the limited circumstances set forth in 5TH CIR. R. 47.5.4. Case: 17-40749 Document: 00514582466 Page: 2 Date Filed: 08/02/2018 No. 17-40749 Accordingly, counsel’s motion for leave to withdraw is GRANTED, counsel is excused from further responsibilities herein, and the APPEAL IS DISMISSED. See 5TH CIR. R. 42.2. 2 Metronews a fait le tour de la presse internationale et vous livre le fait divers du jour... L’arme s’est très, très bêtement retournée contre lui. Lundi, un Américain de 37 ans s’est blessé en recevant une balle dans le poignet alors qu’il était en train de tuer avec son pistolet 7 chiots auxquels il n’arrivait pas à trouver un foyer. D’après les premiers éléments de l’enquête, Jerry Allen Bradford venait de tuer trois des 7 chiots, âgés de trois mois, lorsqu’il en prit deux dans ses bras, bien décidé à poursuivre son œuvre sanglante. Mais tout ne s’est pas passé comme prévu. En effet, avec un chiot dans sa main gauche et l’autre sous le bras droit, le trentenaire a visiblement eu du mal à se concentrer et à viser. Le chiot a posé sa patte sur la détente Quelques secondes d’inattention dont ont profité les chiots. Celui dans la main gauche, qui ne tenait pas en place, s’est tortillé pour échapper à son funeste destin et a opportunément posé sa patte sur la détente de l’arme. Le coup est alors parti directement dans le poignet de Jerry Allen Bradford, rapporte NBCnews.com . Hospitalisé en Floride, le jeune Américain a dû expliquer comment il s’était blessé… conduisant la police a perquisitionner chez lui. Sur place, les forces de l’ordre ont trouvé les cadavres de trois chiots. Les quatre derniers, épargnés par l’intervention inopinée de l’un des leurs, sont en excellente santé. Ils ont été placés dans un chenil en attendant d’être adoptés. Quant au propriétaire, il pourrait avoir de sérieux démêlés avec la justice qui réfléchi à la poursuivre pour actes de cruauté envers les animaux.Over recent years, research and development of light-emitting diodes (hereinafter referred as to “LEDs”) have been advancing at a rapid pace, with various types of LEDs being developed, productized, and used in a wide range of fields. Due to their features of low power consumption, long life, and compactness, LEDs have long been used as operation indicator lights for electronic equipment and the like. These LEDs have been much used in, for example, backlights for liquid crystal panels, various kinds of display boards, electronic signboards, decorative illumination devices and so forth, and have now come to be used in the field of illumination. In the illumination field, they are used for automobile headlights and taillights, in planar illumination devices incorporating a plurality of LEDs, in illumination devices that incorporate LEDs inside a tube and can be used in the same manner as fluorescent tubes, for example. The planar light sources that are used for indoor illumination devices and the like are required to emit light uniformly, but since LEDs have strong light directionality, they are not suitable, without modification, to be used for indoor illumination devices. Accordingly, as light source devices using a related-art LED that are for obtaining illuminating light with planar, uniform illuminance distribution, light source devices in which reflection means is provided on the emitting surface of light so that the light is multiply reflected are well known (see Patent Documents 1 and 2 below). The strong-directionality light of LEDs causes unpleasant brightness called “glare” when it enters eyes directly. Light source devices that, in order to prevent this glare, are designed so that the light emitted from the light source is reflected once or more times at the sidewall of the aperture of reflection means provided inside the light source device or on its reflection surface to pass through the aperture are well known (see Patent Document 1 below). In the light source device set forth in Patent Document 3, a point light source is provided in the bottom of a containing assembly called a casing or housing, and reflection means is provided at the mouth portion of the casing, or more precisely on the surface that faces the point light source, so that the strong-directionality light from the point light source is multiply reflected and uniformized to be emitted. In order to heighten the light utilization rate in the light source device, the casing and the reflection means have inner wall surfaces that are formed from material that has high light reflectivity, low light transmissivity, and low light absorptance. As such material, ultrafinely foamed reflection plate is used. Ultrafinely foamed reflection plate is a material that has, for example, 98% light reflectivity, and 1% each of light transmissivity and light absorptance, and is lightweight and easy to process. With this ultrafinely foamed reflection plate, the casing and reflection means, for example, can be fabricated with ease.DA's office stops using probation agency's drug tests Updated 7:35 pm, Tuesday, August 28, 2012 Paul Becker, director of the Harris County probation department, was questioned about the reliability of the drug tests during a three-day hearing. Paul Becker, director of the Harris County probation department, was questioned about the reliability of the drug tests during a three-day hearing. Photo: Cody Duty DA's office stops using probation agency's drug tests 1 / 1 Back to Gallery The Harris County District Attorney's Office will stop using results from drug tests administered by the county probation department in the wake of testimony from department employees that shoddy record-keeping, human error and lack of oversight may mean none of the 25,000 tests a month can be verified. The decision echoed concerns voiced by defense attorneys and judges about the veracity of test results and mismanagement in the agency. "In recent court testimony, senior adult probation department officials revealed previously undisclosed issues concerning the accuracy and reliability of urinalysis testing performed by and on behalf of their agency," District Attorney Pat Lykos said in a statement Tuesday. "This moratorium will remain in effect until I am assured of the accuracy of the department's test results." Defense lawyers in Houston's criminal courthouse said they expect clients whose cases are complete to try to redeem themselves. "This is going to open the floodgates for people to challenge the validity of their urine samples," said attorney Emily Detoto. "This is going to cause a lot of us to review a lot of our past cases." Footage of I-10 closed and the trafficGodofredo Vasquez, Houston Chronicle North Texas storms continueFox4 AT&T Names First Cities to Get 5G NetworkWibbitz Bridging police & young minority studentsFox 26 Houston The 'Black Panther' effectFox 26 Houston 100 Boys March against violenceFox 26 Houston Isiah Factor Uncensored celebrates crawfish seasonFox 26 Houston NASA engineer approved for proton therapyFox 26 Houston 10 p.m. Feb. 20 FOXRAD ForecastFox 26 Houston She said revelations about the probation department beg the question of how many people have been sent to prison based on shoddy work. "If people's lives are at stake, we want to depend on the reliability of the urinalysis," Detoto said. The district attorney's announcement did not surprise Lisa Andrews, the attorney who investigated the department's procedures while preparing for a hearing in which prosecutors sought to use four positive drug tests to revoke probation for one of her clients. She also subpoenaed thousands of emails and documents to show that the agency's drug test results could not be relied on in court. "Given all the weight and enormity of all the evidence that came in at that hearing, they had no choice," Andrews said of
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user_define_t*)pair_second(ppair))->n_elem == 0); assert_true(*(int*)pair_first(ppair) == 0); t_elem.n_elem = 100; _pair_make_second(ppair, &t_elem); assert_true(((_test__pair_make_second__user_define_t*)pair_second(ppair))->n_elem == 100); assert_true(*(int*)pair_first(ppair) == 0); pair_destroy(ppair); } Michael Craddock Michael Craddock (born April 9, 1956 in Nashville) is a former member of the Metropolitan Council of Nashville and Davidson County, representing the 4th district. In 2011, Craddock announced that he would be running to challenge Karl Dean as the Mayor of Nashville in the August 4th 2011 Metro Elections. In 2019, he was a candidate for Metro Council At Large. Early life Born and raised in Nashville Tennessee. Michael attended Beauna Vista, Glenn, Highland Heights and graduated from East High school in 1974. Education and career In his first term in the Metro Council, Michael Craddock served on the Codes, Fair, and Farmer's Market; Public Safety - Beer and Regulated Beverages; and Traffic and Parking Committees. In his second term, Michael serves as Chair of the Public Safety Committee for 2008, he is also a member of the Codes and Budget and Finance Committees. He currently works as a realtor. He graduated from East Nashville High School in 1974 and the Institute of Real Estate Training in 1980. Bills sponsored Michael Craddock was the author of the idea of installing survelliance cameras in Nashville parks that experienced problems with persons committing deviant sex acts. Michael Craddock also sponsored the mobile vendor bill which prohibits selling items in parking lots. During 2006, Craddock sponsored and obtained approval in the Metro Council for a Charter Amendment to be placed on the November 2006 ballot that would allow the people of Nashville to vote for and create the position of independent Auditor. In the November 2006 election, the people of Nashville overwhelmingly approved the charter amendment and by this August for the first time in the history of Nashville we will have a completely independent auditor. Throughout his tenure in the Metropolitan Council, Craddock has consistently criticized waste of the taxpayers' dollar. In June 2009 Michael sponsored and obtained unanimous approval of a ban on booting vehicles. Craddock has been quoted as saying that he intends to introduce legislation to legitimize the practice and add structure to it. Political positions During his time on the council Craddock has been opposed to many issues seen as supportive to the GLBT community. In 2009, Councilman Craddock voted against a non-discrimination ordinance sponsored by Councilwoman Megan Barry that would extend employment protection to gay and transgender city workers. In 2011, Craddock opposed an ordinance that would extend the 2009 NDO to companies that contract with Metro Government. Craddock was also reported to have said he was "sick to his stomach" at news of a male only strip club coming to Nashville, saying that "If Metro council could do something - you're looking at the man who would do it". Craddock was a consistent critic of plans to bring a convention center to downtown Nashville using general revenue as bond collateral, asking "[h]ow on earth can we justify using tax payer money to build a Convention Center. I’d crawl under the table before I’d tell these people that I’m going to up and raise their taxes." Craddock was skeptical of a 2010 study claiming a large increase in jobs and revenue to the city, saying, "[t]his study says we are going to create 1,524 new jobs, its going to cost us $600million to do that, that's about $400,000 per job, I can think of a better way to spend that $400,000." Craddock was a staunch opponent of plans to redevelop the Tennessee State Fairgrounds and Racetrack for commercial purposes, saying "[t]he fairgrounds is part of my fabric, my culture. I'm ashamed it's been neglected." May 2010 Criminal Court Race The term-limited councilman sought a new position as Criminal Court Clerk of Davidson County. In the May 18, 2010 Democratic Primary election, Craddock was soundly defeated by four-term incumbent David Torrence, receiving only 4,988 votes against Torrence's 10,852. August 2011 Mayoral Race On March 31, 2011 Craddock held a kick-off party at his home for his run to replace Karl Dean as Mayor of Nashville, with a central issue being Dean's attempted redevelopment of the Fairgrounds into commercial property. On April 11, Craddock announced that his campaign had raised $14,075 as of April 1, compared to $520,000 cash on hand claimed by the Dean campaign. Faced with lackluster support and unable to raise much money, Craddock withdrew from the race on May 25; Karl Dean was subsequently reelected by a landslide. References Category:Metropolitan Council members (Nashville, Tennessee) Category:American people of Welsh descent Category:Living people Category:1956 birthsSo much for biometrics and immigration security: A South Korean woman managed to fool a million-dollar fingerprint reading machine in Japanese border controls using a simple piece of tape stuck to her fingers. It happened at Tokyo airport. The woman has repeatedly entered Japan using the same trick without anybody noticing. Japanese officials say that they suspect many others have been doing the same things, demonstrating that the biometric systems they installed in 30 airports in 2007-to the tune of $45 million-are completely useless. The woman was deported in July 2007 for illegally staying in Japan as a bar hostess in Nagano, but she entered again with the system, using the tape and a fake passport allegedly provided by a South Korean broker. [Sidney Morning Herald via Fashion Funky]// Copyright 2009 The Go Authors. All rights reserved. // Use of this source code is governed by a BSD-style // license that can be found in the LICENSE file. // Copyright ©2015 The Gonum Authors. All rights reserved. // Use of this source code is governed by a BSD-style // license that can be found in the LICENSE file. //+build !noasm,!appengine // TODO(kortschak): use textflag.h after we drop Go 1.3 support //#include "textflag.h" // Don't insert stack check preamble. #define NOSPLIT 4 // func Sqrt(x float32) float32 TEXT ·Sqrt(SB),NOSPLIT,$0 SQRTSS x+0(FP), X0 MOVSS X0, ret+8(FP) RET 258 P.3d 9 (2011) 172 Wn.2d 120 In the Matter of the Recall of Mark E. LINDQUIST, Pierce County Prosecuting Attorney, Respondent. No. 85361-4. Supreme Court of Washington, En Banc. Considered April 28, 2011. Decided July 21, 2011. *11 G. Perrin Walker, Mark A. Hood, Daniel C. Montopoli, Vandeberg, Johnson & Gandara, Douglas Warren Vanscoy, David H. Prather, Pierce County Prosecutor's Office, Tacoma, WA, for Respondent. FAIRHURST, J. ¶ 1 Petitioners Albert O. Ugás and Daniel B. Fishburn filed a recall petition against respondent Pierce County Prosecuting Attorney Mark Lindquist, charging him with (1) misfeasance and/or malfeasance and breach of his oath of office for failing to investigate alleged corruption and falsification of records by former Pierce County Assessor-Treasurer Ken Madsen, and (2) obstruction of justice for deterring law enforcement from investigating Madsen. After dismissing petitioners' affidavit of prejudice, Judge James Cayce held the recall petition to be legally and factually insufficient and awarded respondent $50,000 in attorney fees for petitioners' intentionally filing a frivolous recall petition in bad faith. Petitioners moved for direct review of the dismissal of the affidavit of prejudice, the finding that the recall petition was legally and factually insufficient, and the award of attorney fees. We affirm the trial court. FACTS ¶ 2 Ugás is the Pierce County Deputy Assessor-Treasurer, having been promoted to second in authority by current assessor-treasurer Dale Washam. Fishburn became acquainted with the assessor-treasurer's office when Washam asked him to serve on the Pierce County Assessor-Treasurer's citizens commission to investigate the actions of former assessor-treasurer Ken Madsen. Lindquist became the Pierce County prosecuting attorney on September 1, 2009, after the retirement of former prosecuting attorney Gerald Horne. Shortly after the recall petition was filed, Lindquist was retained in the November 2010 election. ¶ 3 It appears that Washam's promotion of Ugás to deputy assessor-treasurer and appointment of Fishburn to the citizens commission were motivated, at least in part, by Washam's desire to continue his campaign against Madsen. Washam himself previously investigated Madsen and even brought a recall petition against Madsen during his tenure as assessor-treasurer. In 2005, Judge
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))$ “[$(\delta)$]{}” $(\forall j \le i)(\exists n < \omega)(\forall n) [n \le m < \omega \rightarrow g_j(x_{\nu_i(m)}) = g_j(x_{\rho_i(m)})$ [$(\varepsilon)$]{}" $(\forall j < i)(\exists n < \omega)(\forall m) (n \le m < \omega \rightarrow g_i(x_{\nu_j(m)}) = g_i(x_{\nu_j(m)})$ “[$(\zeta)$]{}” $\nu_i(n) \ne \rho_i(m)$. Arriving to $i$ let $h_i:i \rightarrow \omega$ be such that $\langle \{ \eta_j \restriction \ell:\ell \in [h_i(j),\omega)\}:j < i\rangle$ are pairwise disjoint (possible as $Y$ is $\mu^+$-free). Now choose $g_i$ such that clause $(\varepsilon)$ holds with $n = h_i(j)$, as the choice of $h,\sigma$ splits the problem. Let $i = \dbcu_{n < \omega} A^i_n,A^i_n \subseteq A^i_{n+1},|A^i_n| < \mu$. Now choose by induction on $n,\alpha = \rho_i(n),\beta = \nu_i(n)$ as distinct ordinals $\in \{ \alpha \in \mu: \alpha \notin \{\nu_i(m),\rho_i(m:m < m\}$ and $pr_1(\alpha) = \eta_i(n)\}$ such that $\langle g_j(x_{\nu_\alpha}):j \in A^i_n \rangle = \langle g_j (x_\beta):j \in A^i_n \rangle$. Let $L$ be generated by $L_0 \cup \{y_{i,m}:i < \lambda,m < \omega\}$ freely except that (the equations of $L_0$ and) $(\dsize \prod_{p \in \bold P_0 \cap n} p) y_{i,n+1} = y_{i,n} + x_{\nu_i(n)} - x_{\rho_i(n)}$. : Suppose $V \models 2^{\aleph_\alpha} = \aleph_{\alpha +2}$. If we use the Easton forcing, $2^{\aleph_n} = \aleph_{n+2}$ we get: $|G| < \aleph_\omega,G$ not free, $\lambda_p(\text{Ext}(G,\Bbb Z))$ uncountable two. In $\aleph_{\omega+1},\aleph_{\omega +2}$ have to look at [@GiSh:597]. So CON$[(\forall L)(\text{Ext}(L,\Bbb Z) \ne 0 \rightarrow (\text{Ent}_p(L,\Bbb Z) \ne 0)]$ is hard. : Do we have compactness for singular for Ext$_p(G,\Bbb Z) = 0$? Let $V \models \kappa$ is supercompact, $\lambda = \text{ cf}(\lambda) > \kappa, GCH$ and $\lambda = \text{ cf}(\lambda) > \lambda_0 \Rightarrow \diamondsuit^*_\lambda$. in some generic extension “[$(*)$]{}” if $L$ is $\aleph_1$-free abelian group, not free $L' \subseteq L \and |L'| < L \Rightarrow L/L'$ not free then [ $\lambda_0(\text{Ext}(L,\Bbb Z)) = 2^{|L|}$ $\lambda_p(\text{Ext}(L,\Bbb Z)) = 2^{|L|}$. ]{} Let $P$ be adding $\lambda$ Cohen reals. : If $\bar \lambda \in \Xi_{\Bbb Z}$ can we derive $\bar \lambda' \in \Xi_{\Bbb Z}$ by increasing some $\lambda_p$’s? : Suppose we choose $\lambda > 2^{\aleph_0}$ strongly inaccessible, $p^*$ prime and add by iterated forcing a $G$ satisfying $r_0 (\text{Ext}(G,\Bbb Z)) = 2^\lambda,r_{p^*}(\text{Ext} (G,\Bbb Z)) =0$. Does not $\bar \lambda \in \Xi_{\Bbb Z} \and p \ne p^* \Rightarrow \lambda_p = \lambda_0$? : If $\bar \lambda^i = \langle \lambda^i_p:p \in \bold P \cup \{0\} \rangle \in \Xi_{\Bbb Z}$ for $i < \alpha$ and $\lambda_p = \dsize \prod_{i < \alpha} \lambda^i_p$, then $\langle \lambda_p:p \in \bold P \cup \{0\} \rangle \in \Xi_{\Bbb Z}$. As if $G = {\underset {i < \alpha} {}\to \bigoplus}$ then Ext$(G,\Bbb Z) = \dsize \prod_{i < \lambda} \text{ Ext}(G,\Bbb Z)$ hence $\lambda_p(\text{Ext}(G,\Bbb Z)) = \dsize \prod_{i < \alpha} \lambda_p (\text{Ext}(G_i,\Bbb Z))$. : In [@EkSh:505] the statement “there is a $W$-abelian group" is characterized. We can similarly characterize “there is a separable group". We have the same characterization for “there is a non-free abelian group" such that for some $p$, $r_p(\text{Ext}(G,\Bbb Z))=0$. : Can $\bold P^* = \{p:p$ prime and $\bar \lambda \in \Xi_{\Bbb Z} \and \lambda_0 > 0 \Rightarrow \lambda_p > 0\}$ be $\notin \{\emptyset,\bold P\}$? If $\lambda$ is strong inaccessible or $\lambda = \mu^+, \mu$ strong limit singular of cofinality $\aleph_0,S \subseteq \{\delta < \lambda:\text{cf}(\delta) = \aleph_0\}$ is stationary not reflecting and $\diamondsuit^*_S$ and $\bold P_0$ a set of primes, there is a $\lambda$-free abelian group $G$ such that $r_0(\text{Ext}(G,\Bbb Z) = 2^\lambda,r_p(\text{Ext}(G,\Bbb Z)) = 0$ and: $p \in \bold P_0 \Rightarrow r_p(\text{Ext}(G,\Bbb Z)) = 2^\lambda$ and $p$ prime and $p \notin \bold P_0 \Rightarrow r_p(\text{Ext}(G,\Bbb Z) =0$. We continue [@GrSh:302a]. For consistency of “no examples" see [@MkSh:418]. 1) We say ${\Cal A}$ is a $(\lambda, \bold I)$-system if ${\Cal A} = (\lambda,\bold I,\bar G = \langle G_\alpha:\alpha \le \omega \rangle, \bar H^t = \langle H^t_\alpha:\alpha \le \omega \rangle, \bar \pi = \langle \pi_{\alpha,\beta}, \pi^t_{\alpha,\beta}:\alpha \le \beta \le \omega,t \in \bold I \rangle, \bar \sigma = \langle \sigma_t:t \in \bold I \rangle)$ satisfies (we may write $\lambda^{\Cal A}, \pi^{t,{\Cal A}}_{\alpha,\beta}$, etc.) “[$(A)$]{}” $\lambda$ is $\aleph_0$ or generally a cardinal of cofinality $\aleph_0$ “[$(B)$]{}” $\langle G_m,\pi_{m,n}:m \le n < \omega \rangle$ is an inverse system whose inverse limit is $G_\omega$ with $\pi_{n,\omega}$ such that $|G_n| \le \lambda$. (So $\pi_{m,n}$ is a homomorphism from $G_n$ to $G_m,\alpha \le \beta \le \gamma \le \omega \Rightarrow \pi_{\alpha,\beta} \circ \pi_{\beta,\gamma} = \pi_{\alpha,\beta}$ and $\pi_{\alpha,\alpha}$ is the identity). “[$(C)$]{}” $\bold I$ is an index set of cardinality $\le \lambda$. For every $t \in \bold I$ we have $\langle H^t_m,\pi^t_{m,n}:m \le n < \omega \rangle$ is an inverse system of groups and $H^t_\omega$ with $\pi^t_{n,\omega}$ being the corresponding inverse limit $H^t_\omega$ with $\pi^t_{m,\omega}$ and $H^t_m$ has cardinality $\le \lambda$. “[$(D)$]{}” for every $t \in \bold I,\sigma^t_n:H
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, 61 of the 472 physicians (13%) who completed the 2013 survey had left Stanford by 2015. Burnout and intent to leave {#Sec10} --------------------------- In the fully adjusted model (Table [3](#Tab3){ref-type="table"}), those who were experiencing burnout had 4.86 times higher odds of intent to leave compare to those who were not experiencing burnout. We also found that for every one point (range: 4--20) increase in depression score, physicians had 22% greater odds of intent to leave (Table [4](#Tab4){ref-type="table"}). There were no statically significant associations between intent to leave and surgical specialty, work hour category, sleep-related impairment or anxiety scores (Table [4](#Tab4){ref-type="table"}).Table 3Association between physicians' intent to leave and burnoutOR (95% CI)*p*-ValueUnadjusted Model6.48 (4.11--10.21)*\< 0.001*Adjusted Model 1^a^6.48 (4.11--10.20)*\< 0.001*Adjusted Model 2^b^7.06 (4.38--1.40)*\< 0.001*Adjusted Model 3^c^6.63 (3.98--11.03)*\< 0.001*Adjusted Model 4^d^4.86 (2.81--8.39)*\< 0.001Abbreviations*: *OR* Odds Ratio, *CI* Confidence Interval^a^ Adjusted for Surgical Specialty^b^ Adjusted for Surgical Specialty, Hours Worked per Week Category^c^ Adjusted for Surgical Specialty, Hours Worked per Week Category, and Sleep-Related Impairment^d^ Adjusted for Surgical Specialty, Hours Worked per Week Category, Sleep-Related Impairment, Anxiety, and DepressionTable 4Association between intent to leave and burnout - details of Model 4OR(95% CI)*p*-ValueBurned Out4.862.81--8.39*\<  0.001*Surgical Specialty1.390.75--2.570.29Very High Work Hours0.510.25--1.050.07High Work Hours0.600.30--1.200.15Moderate Work Hours0.750.37--1.510.42Low Work Hours (reference group)1----Sleep-Related Impairment0.990.95--1.030.63Anxiety1.010.89--1.160.85Depression1.221.06--1.39*0.004Abbreviations*: *OR* Odds Ratio, *CI* Confidence Interval Among physicians who reported one or more symptoms of burnout in 2013, 58.7% indicated intent to leave their practice within 2 years, compared with only 18% of those without burnout symptoms (RR = 3.3; 95% C:2.5--4.3). Therefore, intent to leave of 41% of those who were burned out may be attributed to burnout \[attributable risk = 58.7--18% = 40.7%\] which is about 3.7 times higher than the actual observed rate of subsequent turnover attributable to burnout. Discussion {#Sec11} ========== The results of our analysis indicate that 1) physicians who are experiencing burnout are more than twice likely to leave their practice, and that the effect of burnout on turnover is independent of personal factors such as anxiety or depression; 2) the economic cost of turnover attributable to physician burnout is high, and; 3) intent to leave is a strong predictor of actual departure. Those who reported intent to leave the institution were more than three times as likely to leave within 2 years, compared to those who did not report intent to leave. In this study sample, physicians had modestly higher scores for sleep-related impairment, and similar to median scores for anxiety, and depression to median scores from PROMIS reference populations (the 2000 General US Census and a clinical sample for sleep-related impairment, and the 2000 General US Census for anxiety and depression) \[[@CR37]--[@CR39]\]. Although depression was a significant predictor of intent to leave even after adjusting for other variables, only burnout (an indicator of work-specific distress), rather than depression and anxiety (indicators of general distress) was a significant predictor of actual physician turnover. Similar to other studies, \[[@CR40], [@CR44]\] our results suggest that intent to leave is a strong predictor of physician turnover. In our baseline sample, 28% reported intent to leave the institution within 2 years, and after 2 years 13% of physicians had left Stanford. Those who reported intent to leave in 2013 were more than three times as likely to have left by 2015. Intent to leave may be a valid proxy indicator of turnover to calculate organization-specific financial burden of physician turnover attributable to burnout, when data on actual turnover is not available. However, intent to leave attributable to burnout is much higher than actual subsequent turnover attributable to burnout. An adjustment factor for this difference will improve accuracy when estimating financial burden from intent to leave data where turnover data is not yet available. The adjustment factor indicated by the present study is to divide intent to leave attributable to burnout by 3.7 to estimate actual subsequent turnover attributable to burnout. Additional data from a heterogeneous set of health care organizations will help clarify the variance in difference between intent to leave versus actual subsequent turnover attributable to burnout. Future investigation from a heterogeneous set of health care organizations will also help clarify the variance in economic cost of physician turnover attributable to burnout. Physicians working in academic medical centers often have unique challenges (e.g. academic productivity expectations) and benefits (e.g. opportunities to teach and conduct research) that may affect the relationship between burnout and turnover. The only other published data---to our knowledge---on the association between burnout and turnover indicates an effect of burnout on physician turnover similar in magnitude \[[@CR6]\] to the present study finding, which provides some across-organization validity. However, this collaborating data is also from an AMC, whereas most health care organizations in the United States are not AMCs. It is not clear that these findings will generalize accurately in attempts to estimate cost of turnover attributable to burnout in non-AMC organizations. The only published article to date \[[@CR4]\] that attempts to use turnover attributable to burnout to build an economic argument for investing in physician well-being relies on unpublished data from the present study \[[@CR45]--[@CR47]\]. The present study is limited to observation of the relationship between burnout and subsequent turnover, which provides necessary but far from sufficient evidence of a causal relationship. In addition to an AMC focus, the present study is also limited to secondary data analysis of completely de-identified evaluation data, without demographic data that might be helpful in assessing generalizability of results. With these limitations in mind, the findings of the present study, coupled with previous evidence of effective strategies to mitigate burnout, \[[@CR48]\] suggest feasibility of longitudinal study to determine the effect of interventions to mitigate burnout on cost of physician turnover. Average turnover rates observed at Stanford (13% in 2 years) are similar to national averages. The Cejka Search and American Medical Group Association Physician Retention Survey results show that the annual rate of physician turnover was about 6% in 2010 and 2011 \[[@CR49]\]. If interventions can reduce burnout to half of the current rate, Stanford Medicine may be able to save \$7,772,000 to \$27,753,000 in physician recruitment costs alone during the subsequent 2 years. These figures based on recruitment cost at Stanford, which are comparable to national averages reported elsewhere \[[@CR4], [@CR50]\]. Our estimate of the high cost of turnover attributable to burnout does not include either the loss of revenue due to physician faculty position vacancy or the diminished economic productivity associated with burnout among those who remain employed---such as a reduction in work-hours \[[@CR51]\]. Nor does this estimate include a broader range of costs associated with burnout, such as the disruption in the quality and continuity of direct patient care or the reduced health of physicians \[[@CR9], [@CR52]\]. Investment in interventions to reduce burnout may pay dividends in all of these domains. Conclusion {#Sec12} ========== Our results suggest that the economic cost of physician faculty attrition attributable to burnout is high. This finding may help motivate further investigation to determine the effect of strategies to mitigate burnout on physician turnover and associated economic burden. Academic medical centers offer physicians rewarding careers, including opportunities to develop new frontiers in patient care, create and advance new knowledge, and to educate and mentor trainees. In turn, these institutions benefit immensely from talented physicians who drive high standards in patient care, research, and education. Investing in strategies that prevent or reduce burnout may render economic benefits associated with reduced physician attrition. Perhaps more compelling for AMC-employed physicians and the patients they serve are the benefits that reduced burnout may render to physicians' personal and professional wellbeing and to the quality of clinical care. We would like to thank Marcia Cohen, the Senior Associate Dean for Finance and Administration for the School of Medicine at Stanford University, for providing us the cost estimates of physician recruitment at Stanford. We would also like to express our gratitude to Véronique Grenon, FCAS and Ming Lu at the Risk Authority Stanford for data management, linking and de-identification of the data set. Funding {#FPar1} ======= None Availability of data and materials {#FPar2} ================================== The data that support the findings of this study are property of The Risk Authority Stanford and Stanford Medicine WellMD Center strict restrictions apply to
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"Did you find the other us in time?" "I couldn't get to me, but I found you." "I told him to look for Goldenmire." " I just hope he listened." "He was really off his face." " Oh, so do I." "Because, right now, those two idiots are our last hope." "MUSIC:" "Pedestrian At Best by Courtney Barnett" "# I love you, I hate you I'm on the fence, it all depends" "# Whether I'm up, I'm down, I'm on the mend" "# Transcending all reality" "# I like you, despise you, admire you" "♪ What are we gonna do when everything all falls through...?" "♪"Infection dynamics and acute phase response of an Actinobacillus pleuropneumoniae field isolate of moderate virulence in pigs. Actinobacillus pleuropneumoniae, the causative agent of porcine contagious pleuropneumonia (PCP), causes significant economic losses associated mainly with growth stunting of animals. Although serotypes can be distinguished according to their virulence, most of the studies are focused in A. pleuropneumoniae infections with virulent serotypes. There is little information regarding the role of acute phase proteins (APPs) and proinflammatory cytokines in infections with isolates of mild or moderate virulence. Thus, the present study aims to evaluate the kinetics of infection with an A. pleuropneumoniae serotype 6 (Ap6) field isolate of moderate virulence and the changes in the serum concentration of specific antibodies and different APPs and proinflammatory cytokines. Control animals showed no clinical signs or lesions throughout the study. Infected animals showed increased rectal temperature, respiratory distress and depression from 24hpi, and typical gross and microscopic lesions of PCP from 6hpi onwards. Ap6 was isolated from nasal swabs of four out of five inoculated animals at 24hpi, and from nasal swabs, tonsil and lung samples from all inoculated animals at 72hpi. Specific antibodies against Ap6 or changes in the serum concentration of IL-1β, IL-10 and TNF-α were not detected throughout the study. The serum concentration of IL-6 increased from 6hpi as well as serum A amyloid, C-reactive protein and haptoglobin from 24hpi onwards. Our results highlight the onset of the acute phase response after the infection with a field isolate of A. pleuropneumoniae of moderate virulence from 24hpi onwards which may be of interest in the study of the pathogenesis of this disease.Our Philosophy Festina lente -make haste...slowly Friday, March 2, 2012 Shifting Gears Twenty minutes in the Blue Ridge laundrymat, catching up on wash from the conference and a short vacation/property hunt in Ellijay. In between Columbus and the mountains I slipped down to Valdosta for a root canal, promising myself I would do better with my teeth from now on (if for no other reason than that that kind of work is EXPENSIVE!). Whoo. Not exactly welcome expenses in our world right now. We've found a nice plot - nearly 2 1/2 acres of forest near the Clear Creek area, southeast of Ellijay. We looked at being part of a larger resettlement project on a really world-class property yesterday, but it was just too expensive to be feasible at this point. I wish them the best and I'm sure we'll all be part of the same community of like minds in the region very soon. The property we're in the process of buying is only about 5 miles away from it - so no problem, even at horse-pace... Time frame-wise, we are working the Spring Folk Life Festival at the Agrirama in Tifton - Jess giving a soap-making workshop, and me manning our booth. That is April 14th, I believe, so look for that to be our last trip south to wrap up our business in Tift County. We'll be setting up a nice camp on the new property: 16x20 wall tent on a wood deck (that will have to be built), woodstove and Hoosier cabinet kitchen, real beds, clawfoot tub, couch and coffee table on an area rug (all of which we already have minus the tub - please help if you can!). We will be transplanting some nursery stock into their new (and hopefully permanent) homes at the same time, and erecting a perimeter fence. As soon as we have a more solid weekeend in mind for setting up camp, we would love to have any and all help from anyone who feels like helping! I'll post that announcement here as soon as I can. Good to meet so many fine people at the conference, to hear about such pressing work being done, and we are really looking forward to getting to know as many of you as we possibly can. That's a nifty idea- sort of a tent cabin on 2 and a half acres. My wife and I have talked about doing something similar. There's a community in a picturesque part of southeast Minnesota, and while we might not directly be members of it, we'd purchase some land nearby, plant a food forest, and spend time there in the summers. That's the dream at least. Glad to hear you're really living it. For now we have our garden and food forest in St. Paul. Cheers! jeff zhttp://eighthacrefarm.blogspot.com Howdy, Nicole! So good to hear from you!! Yes, we are well, and really excited about hopefully being off the road for good. It's been too long since we felt like we were home. Wish you could come stomp some cob with us... Jeff, yeah man, 2.34 acres seems like a nice family food forest to me. The property is sort of a bowl-shaped sun-trap facing south/southeast. A little pond at the bottom is definitely on my list of things to do, but for now there is a small lake about 100 yards away, full of panfish, bass, and hopefully some trout, and a pretty little creek flowing out of it parallel to our property. Top shelf mushroom hunting I'm thinking! I sure like what you guys are doing in St. Paul; keep me posted on how the transition plans go! By the way, we are closing on the property March 23rd, so look for a formal workshop announcement very soon! We ordered our big wall tent this morning from Davis Tents in Colorado, custom fit, fly'd, and shipped to us here in south Georgia for $1900. A bit less expensive than anything Nieman Marcus will be offering this holiday season... Toon Followers Follow Small Batch About Me Husband, father of two, ecologist, organic gardener, orchardist, small stocker, mushroom cultivator, cobber, herbalist, teacher, and cultural infidel, who lived in a big tent without power or running water in the north Georgia mountains for two years, now doing the same in a simple wooden structure, muddling toward sustainability one baby step at a time. Every now and then I stumble upon something I deem worth sharing. Even if it's just with myself. Contact Feel free to contact me in regard to the topics of this blog, or my grant-funded Montessori school project 'Operation Self-Reliance,' whether for speaking engagements, workshops, consultation, or just to chat, at: trippticket(at)gmail(dot)com, or simply post to the current thread. Cheers.Chatsworth, Ontario (town) Chatsworth is a community in Grey County, Ontario, Canada, part of the Township of Chatsworth. It is located south of Owen Sound and north of Durham where Highways 6 and 10 merge. The village neighbours Williamsford, Dornoch, and Desboro. History Originally named Johnstown after an early landowner, the post office was renamed Holland East in 1851. It was renamed again to its present name in 1857. The name comes from Chatsworth House, in Derbyshire, near the home town of the postmaster at that time. Chatsworth was founded in 1848 at the northern terminus of the Toronto-Sydenham Colonization Road. Modern Highway 10 follows most of the original road's route. On January 1, 2001, The Village of Chatsworth was merged into the new Township of Chatsworth, along with Holland and Sullivan Townships. Famous Canadian suffragette Nellie McClung was born in Chatsworth. Transportation Chatsworth sits at the junction of Ontario Highway 6 and Ontario Highway 10, which are the modern-day evolutions of the Garafraxa Colonization Road and the Toronto-Sydenham Colonization Road respectively. The Toronto, Grey and Bruce Railway once passed through the village, but that section of its line (then owned by Canadian Pacific) was abandoned in the 1980s. It is served by Kasper Transportation's Owen Sound to Guelph intercity bus route, which began operating in January 2020 with a fourteen-seat passenger van. There are two buses in each direction on Monday to Saturday, one in the morning and one in the afternoon. References Category:Communities in Grey County Category:Former municipalities in Ontario Category:Populated places disestablished in 2001[Hepatocellular carcinoma. Significance of the association with cirrhosis, alcohol consumption and the hepatitis B virus (serum markers and tissue antigens)]. In a consecutive series of 35 cases of HCC, 21 (60%) had a habitual alcoholic intake of greater than 80 g/die and 26 (
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gas atmosphere in order to ensure that the medicine will not become contaminated during storage from exposure to oxygen or other contaminating gases; the inert gas most frequently used is nitrogen. There is a need to provide a quality inspection procedure for the manufacturing process described above, to sample the gas entrapped in the sealed ampule in order to verify that the gas does not contain any substantial quantity of oxygen, in order to confirm that the medicine in the ampule will have an adequate shelf life before use. Unfortunately, because the ampules comprise a sealed glass container, the quality inspection procedure requires that the ampule be broken in order to gain access to the gas contained in the interior, thereby creating a destructive testing process. This means that quality testing can only be done on a sampling basis, wherein random or statistically accurate samples of ampules are withdrawn from the assembly line process for testing. Further, even if a destructive process is used, it is extremely difficult to withdraw a gas sample from the ampule without contaminating the sample.INTRODUCTION {#s1} ============ Chronic Myelogenous Leukemia (CML) is a hematological stem cell disorder characterized by excessive proliferation of cells of the myelogenous lineage \[[@R1]\]. The hallmark of CML is the Philadelphia chromosome, which arises from reciprocal translocation between chromosomes 9 and 22. The molecular consequence of this translocation is the replacement of the first exon of c-Abl with sequences from the Bcr gene resulting in a Bcr-Abl fusion gene whose protein product generates a constitutively activated tyrosine kinase. Found in 95% of patients with CML, Bcr-Abl is also present in approximately 5--10% of adults with acute leukemia for whom there is no evidence of antecedent CML. Bcr-Abl is considered necessary, but may not be sufficient, to cause malignant transformation in CML. Bcr-Abl activates intracellular signal transduction pathways that promote proliferation and genetic instability while suppressing apoptosis and weakening cellular adhesion \[[@R1]\]. Biochemical signaling pathways known to be activated by Bcr-Abl include the PI3K/AKT/mTOR pathway, CRK oncogene-like protein/focal adhesion kinase, the RAS/RAF/MEK/ERK pathway, c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK), and the Signal Transducer and Activator of Transcription (Stat)-5 pathway \[[@R1]--[@R5]\]. Particularly, activation of Stat5 by Bcr/Abl leads to increased expression of genes driving cell cycle progression, promoting survival, and oncogenesis signaling pathways downstream of Bcr-Abl kinase \[[@R6]\]. In contrast, deletion of Stat5 in Bcr-Abl^+^ cells induces apoptosis, even in Bcr-Abl tyrosine kinase inhibitors (TKI)-resistant cells. Furthermore, Stat5 is constitutively active in many forms of hematologic cancers \[[@R5]\], and, aside Bcr-Abl, it is a signaling hallmark of CML and its activity is associated with poor prognosis \[[@R7]\]. The tyrosine kinase inhibitor (TKI) imatinib mesylate (IM), an ATP-competitive selective inhibitor of Bcr-Abl, is the standard first-line therapy for all CML patients \[[@R8]\]. Particularly, 80% of newly diagnosed patients with chronic-phase CML have shown a complete cytogenetic response to treatment with IM over a median follow-up of 54 months. However, although the initial response rates are high, IM fails in up to 40% of patients because of disease resistance or unacceptable side effects which call for alternative therapies to treat CML patients. Both preclinical and clinical studies suggest that the induction of the apoptosis of Bcr-Abl^+^ leukemia cells by IM may be incomplete and patients can develop resistance to TKI \[[@R9]\]. The most frequently reported causes for TKI resistance are mutations in the kinase domain of Bcr-Abl. Other mechanisms include the increased expression of proteins such as Bcr-Abl or the drug transporter ABCB1, TP53 inactivation, elevated levels of granulocyte-macrophage-colony-stimulating factor (GM-CSF), or increased Stat5 activation \[[@R9]\]. To circumvent the resistance, more potent TKI have been approved (e.g., dasatinib and nilotinib). However, these compounds do not show therapeutic activities against all IM-resistant mutants of Bcr-Abl, and finally a long-term tolerability problem has emerged \[[@R8], [@R10]\]. Preclinical and clinical studies suggest that multikinase drugs (i.e., to target alternate Bcr-Abl kinase pathways) might produce better results than "selective" TKI because mitogenesis and drug resistance can occur, in part, via activation of alternate Bcr-Abl mitogenic signals \[[@R10], [@R11]\]. Therefore, the combination of TKI with multikinase inhibitors would be clinically relevant. Notably, the inhibition of phosphoStat5 (pStat5) constitutes a suitable target to abrogate CML cell growth and other types of leukemias, and, it is considered an attractive target to overcome resistance to clinically used Bcr-Abl kinase inhibitors \[[@R12]--[@R14]\]. The biological activities and structural properties of naphthoquinone (NPQ) (mainly 1,4-napthtoquinones and their derivatives) have led to consider them as privileged structures in medicinal chemistry. NPQ-based derivatives have exhibited a wide variety of biological activities which include, among others, anti-inflammatory, cytotoxic, and anticancer activities. Particularly, NPQ derivatives have been shown to suppress Stat signaling pathway in cancer cells \[[@R15], [@R16]\]. Recently, we have discovered the compound CM363 \[4-(1,6,11-trioxo-2,3,4,6,11,12-hexahydro-1H-benzo\[b\]xanthen-12-yl)benzonitrile\] \[[@R17]\], a synthetic NPQ-based derivative that was discovered by transcriptionally based assays and phenotypic cell based screening of a small molecules library. In this study, we report the anti-CML effects of CM363 *in vitro* and *in vivo*. CM363 was characterized as an inhibitor Bcr-Abl-Stat5 signaling pathway that induces cell cycle arrest and apoptosis in CML cells. These effects are enhanced when CM363 is combined with IM. Notably, CM363 is equally effective against IM-sensitive and IM--resistant cells. These findings provide new insights into molecular and cellular mechanisms of a novel multikinase modulator in CML and suggest a potential therapeutic application of this compound in Bcr-Abl- and Stat5-related malignancies. RESULTS {#s2} ======= CM363 inhibits viability of human leukemia cells {#s2_1} ------------------------------------------------ CM363 (Figure [1A](#F1){ref-type="fig"}) was discovered by high-throughput cell based phenotypic screening of a proprietary small molecule library \[[@R17]\]. First, cells transfected with a Stat-response element driving expression of a luciferase reporter gene were used to interrogate that chemical library. From this approach, CM363 was found to inhibit Stat5- or Stat3- (Figure [1B](#F1){ref-type="fig"}) dependent reporter genes. However, CM363 had negligible effects on transcriptional activity that regulates constitutive expression of β-galactosidase or luciferase (data not shown) protein (Figure [1B](#F1){ref-type="fig"}), suggesting that CM363 does not inhibit transcription factors broadly. Second, viability of exponentially growing cells, representative of hematological and solid tumors, was studied in the presence of CM363 for 48 h by using the MTT assay. CM363 was able to inhibit cell viability of all human leukemia cell lines tested (i.e., K562, MOLM.13, MV4.11, HEL, and HL60) with high efficacy (Table [1](#T1){ref-type="table"}). Thus, IC50s for K562 (IC50 = 0.7 ± 0.5 μM), HEL (IC50 = 1.3 ± 0.3 μM), and HL60 (IC50 = 1.3 ± 0.6 μM) cells (Figure [1C](#F1){ref-type="fig"}) were lower than that observed for some non-hematological (i.e., HeLa = 4.8 ± 0.4 μM) and non-malignant (i.e., MRC-5 = 3.5 ± 0.01 μM and PBMC cells \> 5 μM) cells (Table [1](#T1){ref-type="table"} and Figure [1C](#F1){ref-type="fig"}). *In vivo* Live-Cell Imaging of K562 cells corroborated that CM363 (Figure [1D](#F1){ref-type="fig"}) caused a cytostatic effect on cell growth at concentrations lower than 1 μM (IC50~AUC~ = 0.6 ± 0.3 μM) and induced a cytotoxic effect at higher concentrations (EC50~AUC~ = 1.1 ± 0.4 μM). As expected \[[@R18]\], IM caused a cytostatic effect on K562 cells growth (IC50~AUC~ = 0.2 ± 0.1 μM) (data not shown). Time-lapse movies and photomicrograph of each well confirmed the effects of CM363 on K562 cell proliferation (Figure [1E](#F1){ref-type="fig"}). Finally, viability and proliferation of K562 cells were examined after cells were pulsed-exposed to 1--3 μM CM363 for either 6--24 h, followed by CM363 removal from medium, and then grown in the absence of CM363 for additional 1--2 days. Exposure of K562 cells to 3 μM CM363 for 6 h followed
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and more. The interface for Chrome Download Manager is pretty slick. Once it detects an applicable file available for download, it presents a popup window that allows you to either download the file, or cancel the download. Each download is placed in the var/mobile/Media/Downloads directory for easy access with iFile. Initiating the download puts the files into a queue to be downloaded. If the file is fairly large, then you will notice a badge notification on the settings menu for Chrome, which denotes a download in progress. When I could get it working correctly, the badge notifications were a nice touch, making the downloads feel like a native feature instead of a 3rd party afterthought. The developer also promises Notification Center support for notifications of completed downloads when Chrome’s running in the background. Although I didn’t get that little tidbit on video, I can report that it works just as you might expect it to. Despite the bugs, it’s evident that some serious work was put into Chrome Download Manager. Instead of just shoehorning in support for the iPad and the iPhone, it’s clear that it was created with both devices in mind. Make no mistake, this tweak is leaps and bounds above Chrome Download Enabler in terms of look, feel, and performance. If the developer can stamp out the 1.0 bugs, then this is going to be one of the better tweaks to hit the wire in quite some time. Even with the bugs, if you’re interested in scoring Chrome Download Manager for the best price possible, you may want to act now. The developer currently has a special “introductory” promotion where they’re only charging 3 bucks, but they don’t indicate what price the tweak will land at once the promotion is done away with. If interested, then head over to Cydia’s ModMyi repo where you can download it now, and be sure to tell me what you think about it in the comments below.Homeschooling vs. Distance Education – The GOOD & The BAD By Caz | October four, 2018 | This submit might include affiliate hyperlinks, which suggests we might obtain a small fee, without charge to you, for those who make a purchase order via a hyperlink. Learn our Disclosure. I graduated from College in 1997 as a main faculty instructor and headed straight for the worst space in London to show for two years. Since then I’ve principally taught youngsters which have come from deprived circumstances in North Carolina, Dublin, and Bangkok. Apart from my two years educating on the North Shore of Sydney, the place I taught youngsters such because the son of the top of Sony Music Australia, and the son of the Director of AMP. That was fairly bliss (though not with out points.) I assumed I’d be proper on prime of educating my very own baby on this nice Australian street journey. Hmmm. Homeschooling vs. Distance Education If you journey together with your youngsters, you will have two homeschooling choices (nicely at the least in Australia). There are plenty of elements to think about and all of it will depend on your private circumstances and preferences. There isn’t any proper or incorrect means. What’s homeschooling? Homeschooling is when the duty for studying is positioned upon the mother and father. Mother and father have to ensure they’re checking off aims and outcomes for his or her youngster’s stage of studying. It’s a must to plan, implement, and consider after which report that to the authorities. I don’t know a lot past that, however you possibly can take a look at extra info right here. What’s distance schooling? There are lots of youngsters in Australia who stay in distant areas, miles from the closest faculty. Distance Education, or Faculty of the Air because it was as soon as recognized, was created to cater to their education wants. Classes have been despatched by mail and academics train the scholars over radio. These faculties nonetheless function, and in case you are touring, that is, by regulation, your solely choice. We thought-about homeschooling, however couldn’t as a result of we might not have a everlasting residence. For distance schooling, you enroll in a faculty (our college is Sydney Distance Education – SDEPS) they usually ship you two weeks value of classes at a time, with all required assets. There are directions and marking guides, so we simply implement (my dream educating job). Every little thing is aligned to the normal education curriculum and college students are assigned a instructor. They correspond with the instructor by way of Skype, telephone or e-mail. We additionally join with Kalyra’s class and instructor by means of a web-based group portal. getting it accomplished in a restaurant in Melbourne Why we selected, and like, distance schooling We had no selection, it’s the regulation due to our touring circumstances. I’m guessing you might work round these legal guidelines, however we didn’t need to take the danger. The last item we would like is the effort of coping with the federal government and the regulation. I’m not an awesome supporter of the schooling system, however I do consider in a sure construction to studying. The curriculum within the important areas like studying and maths, typically science, is fairly on-level. We definitely gained’t be homeschooling endlessly and I don’t need Kalyra to fall behind. Distance-ed ensures she’s checking off the packing containers. I want accountability. It’s exhausting sufficient for me to remain on process with the education work as it’s with distance schooling. It might be far too straightforward for me to place off the targeted studying actions to only let the youngsters play and discover freely. This does have very constructive factors, however there must be a stability and I don’t assume it’s truthful for my laziness and non-chalance to interrupt my baby’s studying. Different mother and father could also be extra disciplined than me. I’ve spent 15 years researching, planning and getting ready for classes masking all topics. I left educating as a result of I hated it and I used to be drained. I can’t bear the considered having this duty for my very own baby. My endurance for educating her is already actually skinny, simply due to the earlier life I lived. I LOVE that another person has created all of the models of labor and I simply get to do what I really like – facilitate studying. I don’t have time to be a homeschooling mum or dad. It takes plenty of time to plan actions that align with the curriculum. Plus, it’s a must to discover the supplies and be sure that its curriculum and particular person wants aligned. Simply give it to me. Inform me what I’ve to do, give me the supplies and let me do it. With distance schooling, Kalyra nonetheless will get to have a instructor and really feel like she’s concerned in a classroom. Simply yesterday we have been in her digital classroom studying about classmates in Poland and others touring round Australia like she is. Kalyra beloved faculty so that is as shut as we will get to giving her a small possession in it. The GOOD of distance schooling A few of these are positives of homeschooling too. The construction (constructive elements of it) of conventional studying continues to be current. I do know she is checking off all curriculum bins and gained’t fall behind. There’s loads of flexibility with how we manage our day. There’s a lot room for all times studying. It’s much more focused to her wants. One-on-one educating means it takes 1/5 of the time to finish a lesson. They provide you with all the teachings and supplies. It’s tremendous straightforward to implement. Kalyra will get cool movies and audios to take heed to with supported examples of what she’s studying or instructor course. We will work round her power ranges and moods. If we see she is just too drained or her psychological area isn’t conducive to studying we simply put it away and are available again at a greater time. You possibly can by no means do this in a classroom. What’s the purpose if their lovely brains simply aren’t open to receiving at the moment? The BAD of distance schooling It’s nonetheless about checking off bins and far of the training is irrelevant. I get immensely annoyed once I HAVE to do a lesson with Kalyra, regardless of figuring out how pointless it’s. I get annoyed with the schooling system for losing my daughter’s time filling her head with cloud labels like cumulonimbus and altostratus as an alternative of educating her to make use of her 5 senses to know when rain is coming, methods to decide, the best way to get together with others, find out how to handle cash, discover peace inside herself so she will handle uncertainty. You get my drift and you may see the place this rant goes! I’ve not skilled homeschooling, however they are saying there’s extra work for the kid to do with distance schooling. I’m unsure. I feel there’s probably much less for the mother and father, however it relies upon how targeted you plan to be together with your youngsters for homeschooling. I don’t assume it takes as much as a lot time and you’ve got that consolation of figuring out their instructional wants are taken care of.
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succeed," he said. In the beginning, Jack Roosevelt Robinson had a passion for the rights of his people. Really, it was a passion for the rights of every American. 10. The Dream Is Alive in Oakland Across the choppy waters of San Francisco Bay the city of Oakland rises out of the fog, almost like a little boy standing in the back of the classroom. Hey, what about me? When it comes to cable cars and Tony Bennett lyrics and five-star restaurants, Oakland is merely "the other place" to sophisticated San Francisco. As Steve Treder once wrote in Hardball Times, Oakland is "the supporting player, the sidekick to the area's glitzy, overbearing, egotistical star." But when talk turns to baseball and its wonderful history, roles are reversed. Hall of Famers Frank Robinson, Rickey Henderson, Joe Morgan, and Willie Stargell all came from Oakland. Curt Flood, who changed the very fabric of the game in his fight for players' rights, grew up there, as did Vada Pinson, Lloyd Moseby, Gary Pettis, Jimmy Rollins, Dontrelle Willis, and scores of other major leaguers. Billy Martin, who played in the majors and gained fame as a manager, was born and grew up in nearby Berkeley. He was one of the most controversial and colorful managers in the game's history. Pitcher Dave Stewart, who won two games as the A's swept San Francisco in the historic 1989 "Earthquake World Series," grew up in Oakland and remains a favorite son. Stewart, from the moment the Loma Prieta quake struck on October 17, 1989, at 5:04 pm PT, forgot about baseball and for the next 10 days delved into the recovery effort, working around the clock with hundreds of volunteers. He's never forgotten his roots and continues to donate time and money to charities he's created in his homedown. And don't forget Bill Russell. The first black coach in the NBA also hails from Oakland. Since the Oakland Athletic League was formed in 1919, it has produced 61 major league baseball players, 23 professional basketball players, 47 NFL players, and many Olympic gold medalists. "There was so much spirit growing up there," remembers Morgan, one of the game's greatest second basemen, who was elected to the Hall of Fame in 1990. "Watching those older players from Oakland in the big leagues inspired me. "Remember, back in those days, baseball was the sport. There wasn't much else. People weren't that concerned with basketball or football. Your parents, your father, everybody pointed you in that direction. "I think obviously because Jackie Robinson had made such an impact, not only on baseball, but on our country, we looked to baseball. My dad played baseball and I was his batboy. Watching Frank Robinson and the others was a tremendous motivation for kids in the area." Robinson, during an extensive interview with me in December 2013, tried to explain the Oakland phenomenon. "It was like, 'I want to do it too.' It was a chain," he said. "There were a lot of outstanding players, but you had that feeling you wanted to be in the right place at the right time. And, luckily, I was." Rickey Henderson chewed on the question for a few moments. "Yes, it was a great time for sports when I was growing up in Oakland—and long before that," he told me during an interview. "Fathers brought the kids out to play. From their generation they loved playing baseball and other sports. To me, they kept sports alive in Oakland. "Now, the economy has been so bad that we don't have parents taking their kids to play. When I was a kid Mr. Hank Thomas tricked me into playing Babe Ruth baseball. He'd come to my house, get me out of bed, and take me to the ballpark. He'd entice me with a glazed doughnut and a cup of hot chocolate—all that good stuff. "He was so much in to it; he gave us an opportunity to play sports. He was the father around the neighborhood. He got all the kids together, to the ballpark, and to keep them out of trouble. He gave us a chance to play sports." Earlier, in the 1920s and '30s, San Francisco produced the premier players, led by Joe DiMaggio, Lefty O'Doul, Tony Lazzeri, Frank Crosetti, and Joe Cronin. But across the bay, Oakland was becoming more than baseball's best-kept secret. It was sending the likes of Chick Hafey, Lefty Gomez, Ernie Lombardi, Cookie Lavagetto, and Augie Galan to the majors. Jackie Jensen, who graduated from Oakland High School in 1945, was American League MVP in 1958. The quality of baseball talent produced by Oakland beginning in the mid-1950s was extraordinary. In Treder's study, he states: "The explanation of what happened is an intriguing question. Professional sports, baseball included, has always been an attractive pursuit of working-class young men, often children of recent immigrants: note the high proportion of the star players from the Bay Area in the 1920s and '30s with Italian surnames, products of the great Italian immigration to the Bay Area that took place in the 1890 to 1920 period. "A similar dynamic prompted athletically inclined young Bay Area African Americans coming of age in the 1950s to look toward professional baseball—as a means of economic advancement [as well as excitement, fun, travel and fame—and yes, one might read all these as euphemisms for female attention] in an environment which provided few comparable alternatives." There was an outstanding coach named George Powles at Oakland's celebrated McClymonds High School in the 1950s. He had an enormous impact on his young players. Robinson, now MLB's executive vice president for player development, became one of the game's greatest players. Frank, two-time MVP, Rookie of the Year, and a 12-time All-Star, was signed out of McClymonds High in 1953 by the Reds. On October 3, 1974, Cleveland Indians general manager Phil Seghi named Robinson the team's player-manager, Frank thus becoming the first African American manager in major league history. Robinson also managed the Giants, Orioles, Expos, and Nationals and was named American League Manager of the Year in 1989. In many conversations I'd had with Dave Stewart over the years, he often mentioned growing up in Oakland. He'd tell me about playing on fields of the Greenman Field Baseball Complex. "Joe Morgan and Frank Robinson once played on those fields," he'd say, with that fierce look that was his trademark on the mound. "Guys like Curt Flood and Willie Stargell and Vada Pinson. Those fields were all home to them. "When you look at the people who've come out of Oakland, I think you can say we really have something to be proud of." The 1989 World Series matched the A's and Giants, fitting opponents separated by a body of water. Stewart pitched a five-hit, 5–0 complete-game shutout in the first game at the Oakland Coliseum. The A's won the second game 5–1 and after a day off, the Series was to resume at Candlestick Park. The earthquake struck the Oakland–San Francisco area with a magnitude of 7.1 just as thousands of fans were filing into the ballpark to watch batting practice. The destructive nature of the quake was devastating. An hour before it struck, I took a cab from the Hyatt Hotel in Oakland to Candlestick, a route that traveled over the Interstate 880/Nimitz Freeway, a major link to the Oakland–San Francisco Bay Bridge. That freeway collapsed during the quake, killing scores of people. Sixty-three died as a result of the quake. Hours after the collapse, Stewart was at the wreckage, lending a hand. He returned day after day until the Series, after a 10-day interruption ordered by Commissioner Fay Vincent, resumed. Stewart told me he wanted to be there. He owed that to his hometown in this time of need. "I just stand and watch and try to boost the spirits of those people working all night, the people trying to find bodies and cleaning up the rubble, " he said. "I haven't figured out why I'm drawn here, except that for me this isn't something to gawk at like a tourist. This is part of my life." He became a hero in Oakland. It seemed only fitting when the World Series resumed at Candlestick on October 27, Dave Stewart was the winning pitcher in Game 3, a 13–7 rout of the Giants. After the A's, managed by future Hall of Fame manager Tony La Russa, completed the sweep with a 9–6 victory in Game 4, Stewart was named World Series MVP. Stewart, now an agent, pitched for 16 years and was involved in three World Series championships. A 20-game winner for four consecutive years (1987–1990) for the A's, he pitched for five teams and won 168 games. He pitched a no-hitter against the Toronto Blue Jays on June 29, 1990. Fittingly, he returned to his hometown and pitched for the
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ref-type="fig"}. Ninety variants of SRD input matrices were calculated based on the different bit selections and filtering rules for each protein target. The input data matrices for SRD analysis contained the similarity values of the molecules, calculated with each of the 44 similarity measures.Fig. 2Workflow of the input matrix generation and the complete protocol of the study SRD is a novel algorithm based on the calculation of the differences between the object-wise ranks produced by a vector (corresponding to a method, model, similarity metric, etc.), as compared to a reference vector \[[@CR32], [@CR33]\]. The reference can be experimental values as a gold standard, or a consensus produced by data fusion, such as row-average, minimum or maximum, etc. This is related to the basic idea of multicriteria decision making, where the objective is to rank the objects simultaneously by each criterion: using that terminology, the criteria would be the various similarity measures in this case. The basic steps of the protocol are the following: (1) ranking the samples (here, ligands) in their order of magnitude by each column vector (similarity measure), (2) for each sample (ligand), calculating the differences between the ranks produced by each similarity measure and the reference, and (3) summing up the absolute values of the differences for each similarity measure. The resulting sums are called SRD values and can be used to compare the similarity measures: the smaller the SRD value, the closer the measure is to the reference (in terms of ranking behavior). A detailed animation of the calculation procedure can be found as a supplement to our earlier work \[[@CR26]\]. The method is validated with cross-validation and a randomization test as well. The MS Excel SRD macro is freely available for download at: <http://aki.ttk.mta.hu/srd> We should note that besides SRD, a number of methods for the comparison of rankings is reported in the literature, or used routinely by statisticians. Spearman's rank correlation coefficient---probably the most commonly used rank-based statistical test---has been compared to SRD in the paper of Héberger and Kollár-Hunek \[[@CR34]\] as early as 2011, and we have also shown in our recent work the more sophisticated discriminatory power of SRD as compared to Spearman's rho \[[@CR35]\]. An interesting novel application of SRD is in Post-Pareto optimality analysis, where it was clearly shown to be a well-suited decision support tool (by ranking the solutions along the Pareto front) \[[@CR36]\]. More generally: while it is also based on a comparison of rankings, the SRD workflow can be clearly distinguished from rank-based statistical tests, as it involves not one, but three essential steps. The first of these is the definition of the reference vector (i.e. reference ranking), which---depending of the problem---can be a "gold standard" (such as experimental values for the comparison of computational methods for modeling/predicting the same property) or a consensus of the existing (compared) methods, produced with a suitable data fusion technique, such as average, minimum, maximum, etc. This is again problem-dependent, as the reference vector must always represent a hypothetical optimum (or ideal) ranking. (It may involve more than one data fusion technique, if necessary, e.g. in the present work, the hypothetical best similarity measure would be one that produces the highest possible similarity value for active molecules and the lowest possible value for inactives, so our current solution involved the use of maximum values for actives, and minimum values for inactives, see Results section.) Definition of a reference vector is not part of any rank-based statistical test we are aware of. The second step is the calculation of the distance measure itself between the reference vector (ranking) and the rankings produced by the compared methods (here, similarity measures). In the current implementation of SRD, the Manhattan distance is applied: in the case where there are no tied ranks, this is identical to another rank-based distance measure, the Spearman footrule metric \[[@CR37]\]. Koziol related SRD to another distance measure for permutations---namely, the inversion number \[[@CR38]\], but it has less discriminatory power, and has not found any applications yet (to the best of our knowledge). The third step is the application of a meticulous validation approach, involving a randomization (permutation) test and leave-one-out or leave-many-out cross-validation. This step instantly provides answers to two important questions: whether the SRD values characterizing two compared methods (i.e. rankings) are significantly different from each other (cross-validation), and whether there is any among the compared methods (i.e. rankings) that is not significantly better (i.e. not closer to the reference vector) than random rankings (randomization test). The further statistical analysis of SRD values was carried out by factorial analysis of variance (ANOVA). This method is based on the comparison of the average values for the different groups of samples. The input matrices contained the SRD values and several grouping factors such as similarity metrics, symmetricity, metricity, bit selection and filtering rule. The complete procedure of statistical analysis was carried out three times with different pretreatment methods (rank transformation, range scaling, autoscaling). STATISTICA 13 (Dell Inc., Tulsa, OK, USA) was used for the analysis. Results and discussion {#Sec7} ====================== Comparison based on AUC values {#Sec8} ------------------------------ As a first strategy, we have used AUC values for the 10 datasets as a basis for comparison and analysis. The AUC values were calculated with the scikit-learn Python package for each dataset and for each of the 44 similarity measures \[[@CR39]\]. However, a detailed factorial ANOVA analysis revealed that the AUC values are not fit for the proper evaluation of similarity metrics, because the applied ten protein datasets have very different AUC values, leading to different means and very high standard deviations. In this sense, the AUC values are not sensitive enough to find the most or least consistent similarity measures, when using more than one dataset. Figure [3](#Fig3){ref-type="fig"} illustrates the big differences between the protein targets in terms of AUC values, ranging from excellent classification (2H8H and 3ERT, or SRC kinase and estrogen receptor, respectively) to worse than random classification (4M0F and 4XZH, or acetylcholine esterase and aldose reductase, respectively). There is also no clear consensus regarding the relative performances of the various similarity measures, as the shapes of the curves in Fig. [3](#Fig3){ref-type="fig"} are visibly different (and in some cases display opposite trends).Fig. 3Factorial ANOVA with the use of the protein targets and the similarity measures as factors. (AUC values are plotted against the similarity metrics.) The protein targets (with PDB codes) are marked with different colors and marks on the plot. Average values (dots) and 95% confidence intervals (lines) are shown in each case Results based on SRD values {#Sec9} --------------------------- Because of the problem detailed above, we have decided to apply the SRD method for the statistical comparison. Selecting the reference value (data fusion) was not trivial in this particular case, since we have active and inactive ligands as well, where the ideal behavior for a similarity measure is to produce the highest and the smallest similarity values, respectively. Thus, the reference was defined as the minimum or maximum value among the similarity values, depending on the activity of the specific ligand (if it was active, the row-maximum was used, if it was inactive, then row-minimum was used). The analysis was run 90 times altogether, corresponding to each possible combination of 10 protein targets, 3 bit selections, and 3 filtering rules. The original input matrices contained the 44 similarity measures for the different molecules in each case study, but the ranges of these measures were sometimes very different. For example, values close to 0 were typical for the Mou (Mountford) similarity, but values close to 1 were typical for the Yu1 (Yule) similarity. Obviously, in such cases, taking the row minimum as the reference value would favor the former, regardless of the ligand being active or inactive. Thus, an additional round of data pretreatment was essential for the analysis, to provide a valid basis of comparison. Autoscaling, range scaling and rank transformation were applied for this purpose. One example of the original plots produced by the SRD script can be seen in Additional file [1](#MOESM1){ref-type="media"}: Figure S1, where the normalized (scaled) SRD values are plotted in increasing magnitude and the distribution of random SRD rankings (for random numbers) is plotted as a basis of comparison. SRD analysis was performed with fivefold cross-validation to every combination of the original parameters (bit selection, filtering, scaling) and the results (the SRD values) for each similarity measure were collected from every dataset (see Fig. [2](#Fig2){ref-type="fig"}) for a final factorial ANOVA analysis. The collected SRD values for the ten datasets (i.e. target proteins) were used together for the further ANOVA analysis, to allow us more general conclusions. First, we have compared the data pretreatment methods, to select a suitable one for the rest of the analyses. The effect of pretreatment was significant according to ANOVA, meaning that the results were significantly different for the different scaling options, as seen in Fig. [4](#Fig4){ref-type="fig"}. For the further analyses, we have chosen to use autoscaling, as range scaling and rank transformation are more biased and more sensitive
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the Psychic) im sorry you dont care about the father that was interviewed for the segment i do care as i am human For every person who reads this valuable book there are hundreds of naïve souls who would prefer to have their spines tingled by a sensational but worthless potboiler by some hack journalist of the paranormal. You who now read these sentences join a small but wiser minority. Martin Gaardner (Psychology of the Psychic) I really like Eteponge and believe his heart is in the right place and a good deal of effort is placed in his blogs. Having said that, I believe this critique contain less than solid information. Gary Schwartz' experiments on psychics/mediums are less than stellar and as of this date, hasn't even begun to persuade virtually any scientist (with the exception of Dean Radin) that there may be something to mediumship. A serious review of Schwartz' experiment is, unfortunately, laughable. Keeping it in context, back in the day, Eteponge used "Unsolved Mysteries" as a source document for the medium Dorothy Allison which would me like me using Penn & Teller's Bullsh!it as a source for there being no such thing as astrology which, as we all know, would be ridiculous.Sorry Eteponge, but to criticize Dawkins' using Schwartz is, well, like criticizing Stephen Hawkings' "A Brief History of Time" using the Planet of the Apes. For every person who reads this valuable book there are hundreds of naïve souls who would prefer to have their spines tingled by a sensational but worthless potboiler by some hack journalist of the paranormal. You who now read these sentences join a small but wiser minority. Martin Gaardner (Psychology of the Psychic) who cares about double blind test when the tester is a fraudulent EVIL individual (to take money out of the pocket of the grieving is just evil) What I find absolutely hilarious about this, is how Skeptics will bed with a source as biased and error filled as Faux News, with none other than Geraldo (who has a very bad track record for fair reporting) at the helm, blindly accept it as factual reporting, and then never bothering to check to see whether or not it was accurate, selective skepticism at it's finest ... Geraldo of Fox News once did a segment on his show where he attacked Dr. Gary Schwartz and his Research with many false accusations and biased reporting, Gary's response is here ... In what can be described as a character assassination segment on “Geraldo at Large” on Saturday, October 6th, explicit defamatory claims were made against Dr. Gary E. Schwartz concerning his ethics regarding fund raising for afterlife research. The one-sided segment presented interviews with three people – (1) Mr. Knopf, a father grieving the death of his son who had been a former client of Ms. Campbell (2) a medium currently co-starring in the television show Sensing Murder, and (3) Ms. Macy, an investigative reporter hired by Mr. Knopf. The segment was highly selective and biased in its reporting. A summary of the claims, with additional information not shared on the segment, is discussed below. Together they reveal a very different story. Mr. Knopf claimed that Dr. Schwartz engaged in unethical fund raising following the death of his son, including making statements regarding his deceased son’s purported wishes from the other side. What the Geraldo segment did not mention is that (1) it was Mr. Knopf who initiated contact with Dr. Schwartz following Mr. Knopf’s successful private readings with Ms. Campbell, (2) Mr. Knopf claimed that he was a very wealthy man who wanted to honor his deceased son and help support afterlife research, (3) he invited Dr. Schwartz to his home to discuss possible research programs that he would fund, (4) Ms. Campbell provided specific information about his son’s wishes from the other side, (5) Mr. Knopf promised The University of Arizona an unrestricted gift of $100,000 but only followed through with $50,000 to The University of Arizona, (6) Mr. Knopf communicated to Dr. Schwartz that Mr. Knopf had recently been released from spending time in jail, (7) Mr. Knopf also communicated to Dr. Schwartz that he was currently being sued by partners in a medical school he purported to own, and (8) he was upset because Dr. Schwartz refused to participate in a proposed business venture with Mr. Knopf that would compromise Dr. Schwartz’s ethics. Ms. Campbell claimed that she resigned from Dr. Schwartz’s laboratory in 2005, and that this speaks to her opinions regarding Dr. Schwartz’s ethical behavior. What the Geraldo segment did not mention is that (1) new guidelines and procedures for advancing the ethics and scientific understanding for mediums were being formulated at that time, initiated partly by some inappropriate behavior by Ms. Campbell and some other mediums, (2) all mediums would be required to go through a nine step evaluation procedure, including taking a government mandated human subjects ethics examine required of scientists and research staff, plus take a test based on a book describing previous scientific research with mediums, (3) Ms. Campbell was upset that she would have to undergo the required testing for the new guidelines and procedures, (4) she decided not to participate in the testing, and therefore (5) she was about to be let go by the laboratory, and chose to resign instead. Ms. Macy claimed that she had interviewed other individuals who had been approached by Dr. Schwartz for research funding in an unethical manner. What the Geraldo segment did not mention is that (1) Ms. Macy had previously contributed to the spreading of a false rumor concerning fund raising related to Dr. Schwartz and the Forever Family Foundation, and that (2) after being confronted with the facts, she had written a formal letter of apology to Dr. Schwartz for her being part of spreading the false rumor. One wonders why “Geraldo at Large” presented such a one sided story. Geraldo made a point on the show of reporting that Dr. Schwartz did not return their calls, with an implicit negative connotation. The truth is that there was no genuine attempt by the Geraldo show to contact Dr. Schwartz to have a fair representation of both sides of this story. What Geraldo failed to mention was that the call to Dr. Schwartz’s office was made only after closing hours of his office on Friday, October 5, for a show that was ready to be aired on Saturday, October 6. Also, a call had been made to Dr. Schwartz’s home late Friday night. As it happened, both Dr. Schwartz and his wife were out of town that weekend. They returned to Tucson on Sunday evening, October 7, after the show had aired. As the title “Veritas Research Program” (http://veritas.arizona.edu ) indicates, Dr. Schwartz and his colleagues are concerned with truth. As Dr. Schwartz reports on his laboratory’s website (http://lach.web.arizona.edu/hos.htm),“Responsibility to the truth is the heart of science.” The Geraldo segment about Dr. Schwartz reveals a striking disregard for balanced truth in reporting. Legal action will be taken against each and every individual who has made defamatory comments against Dr. Schwartz, and the truth will be brought out in the court room 1. 1 An expanded and more academic discussion of these issues – including the philosophy and consequences of erroneous character assassination – will be available at a future date." Funny how I hear skeptics say this, and yet, I've listened to interviews where Dr. Gary Schwartz has been interviewed, where he has been asked about the same skeptical criticisms that are in the skeptical articles about him (which are usually attacking his early 2000-2003 experiments, before he stepped up the protocols and tightened the controls) and I've listened to him shoot them down over and over again calmly and rationally. ProfWag wrote:Keeping it in context, back in the day, Eteponge used "Unsolved Mysteries" as a source document for the medium Dorothy Allison Again, you misinterpret and distort what I actually did. More like "keeping it out of context" ProfWag. What I did FOR THE RECORD ... I used VIDEO INTERVIEWS with Dorothy Allison, the Police Detectives, and the Victim's Family Members who consulted Dorothy, from Unsolved Mysteries, BECAUSE THEY ARE THE *ONLY KNOWN VIDEO INTERVIEWS TO EXIST* with those individuals. My main source was *NOT* Unsolved Mysteries, it was Dorothy Allison: A Psychic Story (the book), among several newspaper articles (including one from the new york times), and several misc articles and sources (including a few skeptic sources). The video interviews from UM were important because you have the Police Detectives and Family of the Victims going on record, in video, about the cases, confirming Dorothy's account of the events. That's the actual context. It's pissing me off having to reclarify this all the time when a Skeptic gets it wrong. by the way telling something ¨calmly¨ doesnt mean ANYTHING but to believers that just shows you how lower the standard is for believers than it is for critical thinkers. For every person who reads this valuable book there are hundreds of naïve souls who would prefer to have their spines tingled by a sensational
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10-455],[@b11-tcrm-10-455] Indications for arteriography of the affected kidney and superselective renal artery embolization are: - continuous increasing perirenal hematoma; - severe renal injuries such as renal lacerations; - renal A--V fistula or pseudoaneurysm formation; and - persistent hematuria or fall of blood pressure after active Anti shock therapy.[@b11-tcrm-10-455] However, open surgery is still suggested in cases with both arterial and venous vascular injuries or pelvic injuries.[@b11-tcrm-10-455] Before initiation of this intervention therapy, CT and other imaging examinations should be performed, to confirm the location and degree of injury and determine whether or not there are complicated injuries to the brain, lungs and other organs in the pelvic and abdominal cavities, as long as conditions permit, after emergency fluid resuscitation and anti-shock treatment. The 16 patients in our study all received a whole-body CT scan and preoperative renal arteriography, confirming that hemorrhage was in the renal artery or the segmental or distal renal artery branches. There was one patient who received balloon-catheter occlusion for renal artery trunk laceration and was transferred immediately to surgery for emergency nephrectomy. In the remaining 15 patients, superselective cannulation was performed to the hemorrhagic artery, and spring steel coils with gelatin sponge particles were used to permanently embolize the affected artery. Hematuria disappeared 5--12 days after surgery, indicating that the hemostatic effect was satisfactory. In addition, no significant impairment to renal function was observed after surgery. Internal iliac angiography showed rupture of the arterial branches in two patients complicated with pelvic fracture, in whom artery embolization was performed successfully. It is reported in the literature that the success rate of using arterial embolization for the treatment of hemorrhage from pelvic fracture is 85%--94%.[@b12-tcrm-10-455] Short-term complications after superselective renal artery embolization include embolization syndrome, recurrence of renal hemorrhage due to falling off of emboli, renal function impairment, and nephrogenic hypertension. Long-term complications include perirenal or renal abscess, renal function impairment, and nephrogenic hypertension.[@b10-tcrm-10-455] It is often difficult to identify embolization syndrome because it may be confused with, or clouded by, the underlying traumatic symptoms. Three patients in our series developed post-embolization syndrome presenting as nausea and vomiting, local abdominal distension and low-grade fever. These symptoms disappeared after symptomatic treatment on the basis of excluding any significant cerebral injury. Renovascular hypertension from non-specific embolism of the renal artery branch is a more serious complication. Although it is quite rare, it may lead to nephrectomy. No postoperative nephrogenic hypertension, perirenal abscess or renal function impairment was observed in our 14 patients who received kidney-preservation surgery during the follow-up periods from 8 months to 9 years. In conclusion, superselective transcatheter renal artery embolization is an effective, minimally invasive option for the treatment of BRT hemorrhage, and is well worthy of wider clinical applications. **Disclosure** The authors report no conflict of interest in this work. ![Before treatment two segmental renal arteries, both the anterior and the posterior branches, were injured, (the arrows point to the bleeding sites).](tcrm-10-455Fig1){#f1-tcrm-10-455} ![After treatment two segmental renal arteries, both the anterior and the posterior branches, were injured, (the arrows point to the embolization sites).](tcrm-10-455Fig2){#f2-tcrm-10-455} Age-related thymic activity in adults following chemotherapy-induced lymphopenia. The potential role of the adult thymus in T-cell homeostasis subsequent to lymphopenia remains the subject of debate. We examined whether thymic activity contributes to reconstitution of the peripheral T-cell pool, a critical process for patients recovering from antineoplastic therapy. In selected patients with various neoplastic diseases we assessed peripheral blood lymphocyte subsets by flow-cytometry, including thymus-derived, CD4+ T cells expressing the CD45RA molecule, and thymic size rebound by CT scan before, and 3, 6 and 12 months after completion of cytotoxic therapy. Adult patients (n = 21, mean age of 30 years, range 18-49) had higher baseline numbers of B and lower numbers of NK cells than elderly patients (n = 15, mean age of 79 years, range 70-91), while total T-cell numbers did not differ. Despite the reduction of lymphocyte counts being comparable in the adult (mean of 45%) and elderly (mean of 49%) groups, occurring at, or near, completion of treatment, an enlargement of the previously atrophic thymus was evident in 63% of the adult, but in none of the elderly, subjects. In 22 patients who remained active disease-free during the following year, B cells and NK cells recovered to pretreatment levels as soon as at 3 months, whereas overall T-cell recovery occurred at 6 months post-treatment. Thymic rebound, observed in 11 of 22 patients who were of younger age, correlated significantly with a faster and more complete recovery of CD45RA+ CD4+ (mainly helper-naïve) T cells. The adult thymus appears capable of regeneration, at least up to middle age, contributing significantly to the reconstitution of the peripheral T-cell pool following chemotherapy-induced lymphopenia. In advanced age, however, although peripheral homeostatic pathways appear intact, regeneration of the naïve repertoire is incomplete.High Powered Headlines August 1, 2014 Massachusetts Candidate for Attorney General Would Mandate Smart Gun Technology Warren Tolman who is competing with Maura Healey for Attorney General of Massachusetts says he would mandate all new guns in Massachusetts be fitted with “smart-gun” fingerprint recognition technology. Healey has accused Tolman of softening on his threat. However, Tolman’s website says, “It’s time we use the power of this law to protect the health and safety of our citizens to do what Congress can’t—require gun manufacturers to utilize existing personalized gun technology for all weapons sold in the commonwealth.” Healey’s stance is one of not mandating the technology, but will welcome guns in the state that have built-in smart gun technology as a means to curb gun violence.Click here to read the entire story. Colorado Magazine Capacity Restrictions Law Appealed Again A group of Colorado sheriffs, gun shops, citizens, Colorado Farm Bureau and the Colorado Outfitters Association filed a notice in court on Monday, July 28 to once again appeal Colorado’s magazine capacity restriction and universal background check laws. On June 26, another group lost its suit against the state claiming the laws are unconstitutional.Click here to read the entire story. DOJ Ordered to Release Fast and Furious Documents After 16 months of withholding documents related to Fast and Furious, a judge from the U.S. District Court for the District of Columbia ruled the Department of Justice must turn over a “Vaughn index” of all materials related to the scandal. “Finally, we may get some accountability for Border Patrol Agent Brian Terry and the countless others murdered as a result of the insanely reckless Obama administration program,” says Judicial Watch president Tom Fitton.Click here to read the entire story. Hornady Critical Duty 9mm Ammo Recall Hornady has issued a recall on its Critical Duty 9mm 135-grain +P ammunition due to “light or no powder charges” in a single lot. The item number is 90226, with lot number 3141635. Using this ammo could damage your firearm or yourself. If you have a box of this ammo, do not use it and call Hornady for exchange information.Click here to read the entire story. Everytown for Gun Safety Commercial Backfires Bloomberg’s Everytown for Gun Safety anti-gun organization released a commercial pushing for more gun control in which a man breaks into a woman’s house and proceeds to shoot her. On Tuesday’s The View, the hosts of the talk show aired the commercial and proceeded to discuss the commercial was the exact reason why three out of four of them own a firearm.Click here to read the entire story. Pentagon Loses $626 Million Worth of Weapons A recent report reveals the Pentagon has lost 203,000 guns sent to Afghanistan over the last ten years. Due to faulty reporting and record keeping, $626 million worth of weapons are unaccounted for. Some worry these weapons will fall into the hands of terrorists.Click here to read the entire story. Currently, Cheaper Than Dirt! carries over 1,000 products made by Under Armour, for men and women both. Under Armour Performance Clothing You know us for our selection of ammo and for the best prices on the web for firearms. But you probably don’t know Cheaper Than Dirt! for all things outdoors. We have worked hard in the last year to expand our inventory exponentially. We add an average of 200 new products a day to our website. We are proud to offer a full line of fishing, camping, water sports and law enforcement products to fulfill our outdoor-loving customers’ needs. This includes having the largest selection of clothing we have ever carried. Not only tactical clothing for police and shooters or camo for hunters, but we now carry the most well-known brand of athletic gear—Under Armour. Currently, Cheaper Than Dirt! has over 1,000 products made by Under Armour, for men and women both. Included are Under Arm
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parameter (say string) because the RowCallback processor does not return any object. It is up to subclasses of RowCallback to collect state due to processing the result set which is later queried.</para> </sect2> </sect1> <sect1 xml:id="ado-datatable-dataset"> <title>DataTable and DataSet</title> <para>AdoTemplate contains several 'families' of methods to help remove boilerplate code and reduce common programming errors when using DataTables and DataSets. There are many methods in AdoTemplate so it is easy to feel a bit overwhelmed when taking a look at the SDK documentation. However, after a while you will hopefully find the class 'easy to navigate' with intellisense. Here is a quick categorization of the method names and their associated data access operation. Each method is overloaded to handle common cases of passing in parameter values.</para> <para>The 'catch-all' Execute methods upon which other functionality is built up upon are shown below.</para> <para>In <property>Spring.Data.Core.AdoTemplate</property></para> <itemizedlist> <listitem> <para><literal>object Execute(IDataAdapterCallback dataAdapterCallback)</literal> - Execute ADO.NET operations on a IDbDataAdapter object using an interface based callback.</para> </listitem> </itemizedlist> <para>Where <literal>IDataAdapterCallback</literal> is defined as</para> <programlisting language="csharp">public interface IDataAdapterCallback { object DoInDataAdapter(IDbDataAdapter dataAdapter); }</programlisting> <para>The passed in <literal>IDbDataAdapter</literal> will have its <property>SelectCommand</property> property created and set with its <property>Connection</property> and <property>Transaction</property> values based on the calling transaction context. The return value is the result of processing or null.</para> <para>There are type-safe versions of this method in <literal>Spring.Data.Generic.AdoTemplate</literal></para> <itemizedlist> <listitem> <para><literal>T Execute&lt;T&gt;(IDataAdapterCallback&lt;T&gt; dataAdapterCallback) </literal>- Execute ADO.NET operations on a IDbDataAdapter object using an interface based callback.</para> </listitem> <listitem> <para><literal>T Execute&lt;T&gt;(DataAdapterDelegate&lt;T&gt; del) </literal>- Execute ADO.NET operations on a IDbDataAdapter object using an delegate based callback.</para> </listitem> </itemizedlist> <para>Where IDataAdapterCallback&lt;T&gt; and DataAdapterDelegate&lt;T&gt; are defined as</para> <programlisting language="csharp">public interface IDataAdapterCallback&lt;T&gt; { T DoInDataAdapter(IDbDataAdapter dataAdapter); } public delegate T DataAdapterDelegate&lt;T&gt;(IDbDataAdapter dataAdapter);</programlisting> <sect2 xml:id="ado-datatable"> <title>DataTables</title> <para>DataTable operations are available on the class <literal>Spring.Data.Core.AdoTemplate</literal>. If you are using the generic version, <literal>Spring.Data.Generic.AdoTemplate</literal>, you can access these methods through the property <property>ClassicAdoTemplate</property>, which returns the non-generic version of AdoTemplate. DataTable operations available fall into the general family of methods with 3-5 overloads per method.</para> <itemizedlist> <listitem> <para><methodname>DataTableCreate</methodname> - Create and Fill DataTables</para> </listitem> <listitem> <para><methodname>DataTableCreateWithParameters</methodname> - Create and Fill DataTables using a parameter collection.</para> </listitem> <listitem> <para><methodname>DataTableFill</methodname> - Fill a pre-existing DataTable.</para> </listitem> <listitem> <para><methodname>DataTableFillWithParameters</methodname> - Fill a pre-existing DataTable using a parameter collection.</para> </listitem> <listitem> <para><methodname>DataTableUpdate</methodname> - Update the database using the provided DataTable, insert, update, delete SQL.</para> </listitem> <listitem> <para><methodname>DataTableUpdateWithCommandBuilder</methodname> - Update the database using the provided DataTable, select SQL, and parameters.</para> </listitem> </itemizedlist> </sect2> <sect2 xml:id="ado-dataset"> <title>DataSets</title> <para>DataSet operations are available on the class <literal>Spring.Data.Core.AdoTemplate</literal>. If you are using the generic version, <literal>Spring.Data.Generic.AdoTemplate</literal>, you can access these methods through the property <property>ClassicAdoTemplate</property>, which returns the non-generic version of AdoTemplate. DataSet operations available fall into the following family of methods with 3-5 overloads per method.</para> <itemizedlist> <listitem> <para><methodname>DataSetCreate</methodname> - Create and Fill DataSets</para> </listitem> <listitem> <para><methodname>DataSetCreateWithParameters</methodname> - Create and Fill DataTables using a parameter collection.</para> </listitem> <listitem> <para><methodname>DataSetFill</methodname> - Fill a pre-existing DataSet</para> </listitem> <listitem> <para><methodname>DataSetFillWithParameters</methodname> - Fill a pre-existing DataTable using parameter collection.</para> </listitem> <listitem> <para><methodname>DataSetUpdate</methodname> - Update the database using the provided DataSet, insert, update, delete SQL.</para> </listitem> <listitem> <para><methodname>DataSetUpdateWithCommandBuilder</methodname> - Update the database using the provided DataSet, select SQL, and parameters.</para> </listitem> </itemizedlist> <para>The following code snippets demonstrate the basic functionality of these methods using the Northwind database. See the SDK documentation for more details on other overloaded methods.</para> <para><programlisting language="csharp">public class DataSetDemo : AdoDaoSupport { private string selectAll = @"select Address, City, CompanyName, ContactName, " + "ContactTitle, Country, Fax, CustomerID, Phone, PostalCode, " + "Region from Customers"; public void DemoDataSetCreate() { DataSet customerDataSet = AdoTemplate.DataSetCreate(CommandType.Text, selectAll); // customerDataSet has a table named 'Table' with 91 rows customerDataSet = AdoTemplate.DataSetCreate(CommandType.Text, selectAll, new string[] { "Customers" }); // customerDataSet has a table named 'Customers' with 91 rows } public void DemoDataSetCreateWithParameters() { string selectLike = @"select Address, City, CompanyName, ContactName, " + "ContactTitle, Country, Fax, CustomerID, Phone, PostalCode, " + "Region from Customers where ContactName like @ContactName"; DbParameters dbParameters = CreateDbParameters(); dbParameters.Add("ContactName", DbType.String).Value = "M%'; DataSet customerLikeMDataSet = AdoTemplate.DataSetCreateWithParams(CommandType.Text, selectLike, dbParameters); // customerLikeMDataSet has a table named 'Table' with 12 rows } public void DemoDataSetFill() { DataSet dataSet = new DataSet(); dataSet.Locale = CultureInfo.InvariantCulture;
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moid((syn0[0] + syn0[1] + syn0[2])/3.0) layer_2 = (innerProd(syn1[0],layer_1,M_onehot[len(layer_1) - 2][0],l) / float(scaling_factor))[0:2] print("True Pred:" + str(output_dataset[row_i]) + " Encrypted Prediction:" + str(layer_2) + " Decrypted Prediction:" + str(s_decrypt(layer_2) / scaling_factor)) Iter:0 Encrypted Loss:84890656 Decrypted Loss:2.529 Alpha:0.015 Iter:10 Encrypted Loss:69494197 Decrypted Loss:2.071 Alpha:0.015 Iter:20 Encrypted Loss:64017850 Decrypted Loss:1.907 Alpha:0.015 Iter:30 Encrypted Loss:62367015 Decrypted Loss:1.858 Alpha:0.015 Iter:40 Encrypted Loss:61874493 Decrypted Loss:1.843 Alpha:0.015 Iter:50 Encrypted Loss:61399244 Decrypted Loss:1.829 Alpha:0.015 Iter:60 Encrypted Loss:60788581 Decrypted Loss:1.811 Alpha:0.015 Iter:70 Encrypted Loss:60327357 Decrypted Loss:1.797 Alpha:0.015 Iter:80 Encrypted Loss:59939426 Decrypted Loss:1.786 Alpha:0.015 Iter:90 Encrypted Loss:59628769 Decrypted Loss:1.778 Alpha:0.015 Iter:100 Encrypted Loss:59373621 Decrypted Loss:1.769 Alpha:0.015 Iter:110 Encrypted Loss:59148014 Decrypted Loss:1.763 Alpha:0.015 Iter:120 Encrypted Loss:58934571 Decrypted Loss:1.757 Alpha:0.015 Iter:130 Encrypted Loss:58724873 Decrypted Loss:1.75 Alpha:0.0155 Iter:140 Encrypted Loss:58516008 Decrypted Loss:1.744 Alpha:0.015 Iter:150 Encrypted Loss:58307663 Decrypted Loss:1.739 Alpha:0.015 Iter:160 Encrypted Loss:58102049 Decrypted Loss:1.732 Alpha:0.015 Iter:170 Encrypted Loss:57863091 Decrypted Loss:1.725 Alpha:0.015 Iter:180 Encrypted Loss:55470158 Decrypted Loss:1.653 Alpha:0.015 Iter:190 Encrypted Loss:54650383 Decrypted Loss:1.629 Alpha:0.015 Iter:200 Encrypted Loss:53838756 Decrypted Loss:1.605 Alpha:0.015 Iter:210 Encrypted Loss:51684722 Decrypted Loss:1.541 Alpha:0.015 Iter:220 Encrypted Loss:54408709 Decrypted Loss:1.621 Alpha:0.015 Iter:230 Encrypted Loss:54946198 Decrypted Loss:1.638 Alpha:0.015 Iter:240 Encrypted Loss:54668472 Decrypted Loss:1.63 Alpha:0.0155 Iter:250 Encrypted Loss:55444008 Decrypted Loss:1.653 Alpha:0.015 Iter:260 Encrypted Loss:54094286 Decrypted Loss:1.612 Alpha:0.015 Iter:270 Encrypted Loss:51251831 Decrypted Loss:1.528 Alpha:0.015 Iter:276 Encrypted Loss:24543890 Decrypted Loss:0.732 Alpha:0.015 Final Prediction: True Pred:[0] Encrypted Prediction:[-3761423723.0718255 0.0] Decrypted Prediction:[-0.112] True Pred:[1] Encrypted Prediction:[24204806753.166267 0.0] Decrypted Prediction:[ 0.721] True Pred:[1] Encrypted Prediction:[23090462896.17028 0.0] Decrypted Prediction:[ 0.688] True Pred:[0] Encrypted Prediction:[1748380342.4553354 0.0] Decrypted Prediction:[ 0.052] Things to takeaway: The weights of the network are all encrypted. The data is decrypted... 1s and 0s. After training, the network could be decrypted for increased performance or training (or switch to a different encryption key). The training loss and output predictions are all also encrypted values. We have to decode them in order to be able to interpret the network. Part 9: Sentiment Classification So, now that we know how to encrypt and decrypt messages (And compute basic addition and multiplication), it's time to start trying to expand to the rest of the operations we need to build a simple XOR neural network. While technically neural networks are just a series of very simple operations, there are several combinations of these operations that we need some handy functions for. So, here I'm going to describe each operation we need and the high level approach we're going to take (basically which series of additions and multiplications we'll use). Then I'll show you code. For detailed descriptions check out this work As a general disclaimer, there might be more effient ways of accomplishing these methods, but I didn't want to risk compromising the integrity of the homomorphic encryption scheme, so I sortof bent over backwards to just use the provided functions from the paper (with the allowed extension to sigmoid). Now, let's see how these are accomplished in Python.Now, there's one bit that I haven't told you about yet. To save time, I'm pre-computing several keys, , vectors, and matrices and storing them. This includes things like "the vector of all 1s" and one-hot encoding vectors of various lengths. This is useful for the masking operations above as well as some simple things we want to be able to do. For example, the derivive of sigmoid is sigmoid(x) * (1 - sigmoid(x)). Thus, precomputing these variables is handy. Here's the pre-computation step.If you're looking closely, you'll notice that the H_sigmoid matrix is the matrix we need for the polynomial evaluation of sigmoid. :) Finally, we want to train our neural network with the following. If the neural netowrk parts don't make sense, review A Neural Network in 11 Lines of Python . I've basically taken the XOR network from there and swapped out its operations with the proper utility functions for our encrypted weights.When I train this neural network, this is the output that I see. Tuning was a bit tricky as some combination of the encryption noise and the low precision creates for somewhat chunky learning. Training is also quite slow. A lot of this comes back to how expensive the transpose operation is. I'm pretty sure that I could do something quite a bit simpler, but, again, I wanted to air on the side of safety for this proof of concept. To make this a bit more real, here's the same network training on IMDB sentiment reviews based on a network from Udacity's Deep Learning Nanodegree. You can find the full code here import time import sys import numpy as np # Let's tweak our network from before to model these phenomena class SentimentNetwork: def __init__(self, reviews,labels,min_count = 10,polarity_cutoff = 0.1,hidden_nodes = 8, learning_rate = 0.1): np.random.seed(1234) self.pre_process_data(reviews, polarity_cutoff, min_count) self.init_network(len(self.review_vocab),hidden_nodes, 1, learning_rate) def pre_process_data(self,reviews, polarity_cutoff,min_count): print("Pre-processing data...") positive_counts = Counter() negative_counts = Counter() total_counts = Counter() for i in range(len(reviews)): if(labels[i] == 'POSITIVE'): for word in reviews[i].split(" "): positive_counts[word] += 1 total_counts[word] += 1 else: for word in reviews[i].split(" "): negative_counts[word] += 1 total_counts[word] += 1 pos_neg_ratios = Counter() for term,cnt in list(total_counts.most_common()): if(cnt >= 50): pos_neg_ratio = positive_counts[term] / float(negative_counts[term]+1) pos_neg_ratios[term] = pos_neg_ratio for word,ratio in pos_neg_ratios.most_common(): if(ratio > 1): pos_neg_ratios[word] = np.log(ratio) else: pos_neg_ratios[word] = -np.log((1 / (ratio + 0.01))) review_vocab = set() for review in reviews: for word in review.split(" "): if(total_counts[word] > min_count): if(word in pos_neg_ratios.keys()): if((pos_neg_ratios[word] >= polarity_cutoff) or (pos_neg_ratios[word] <= -polarity_cutoff)): review_vocab
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any sale for pictures. "There is no sale for mine," she answered. "I do not expect to sell any." "Then," said George, "it's a waste of time to paint them." "I do not paint," the girl replied. "My ambition was not dressed in colors." Mrs. Goodwin smiled upon her, and Mrs. Blakemore drew her husband's attention to what she termed the bright aptness of the remark. George said that it did not make any difference whether art was done with a brush or pencil, it was a waste of time if it failed to sell; and hereupon Mrs. Stuvic began to sniff as a preliminary to an important statement. "A man boarded with me a while last winter that could knock 'em all out when it comes to makin' pictures with a pen," she said. "He drew a bird without takin' his pen up from the paper, and it looked for all the world like it was flyin'. But when that was said all was said. He wan't no manner account. He went away owin' me. Now, what does he want to go to Antioch for? I'd just like for somebody to tell me that." "The man that drew the bird?" George spoke up. "Oh, you keep still. I mean Milford." "Probably the woman he's been working for so hard has moved into the neighborhood," said George. Mrs. Stuvic declared that you never could tell what a man was working for. No man was worth trusting. She knew; she had tried them. Milford was no better than the rest of them. Why didn't he explain himself? Why didn't he stand out where every one could see him? She had defended him. She was getting tired of it. He had not rewarded her with his confidence. He came a stranger and had been a stranger ever since. One of these days he might set fire to the house and run away. "You shall not talk about him so," the girl declared. "No one shall abuse him." "Good for you," Mrs. Stuvic cried. "I've been fightin' his battles all along and I'm glad to get some help. Why, she looks like a cat, don't she? And it's what I like to see, I tell you. But it's usually the way; a man works for one woman and is took up for and defended by another." "He is not working for any woman, madam," said Gunhild. "No woman has any claim on him." Mrs. Blakemore shook her head. "With that dark, handsome face it would be difficult long to escape the claim of a woman." "Come off," said George. "I don't see anything so killing about him." "Men never see killing features in man," his wife replied. "They are left for softer eyes to discover." "Oh," he rejoined, looking worriedly at her. "The 'peach,'" she whispered. "Am I to hear that again?" He scratched upon an envelope and handed to her the words: "I give in. Let us call it even and quits." Mrs. Goodwin looked at Gunhild as if by a new light. Next in importance to the discovery of genius itself, is the discovery that genius is picking its way along the briary path of love, lifting a thorny bough in bloom to peep blushingly from a hiding place, or boldly to tear through the brambles out into the open, and in honest resentment defy the wondering gaze of the common eye. It would be a pretty sight to see this girl in love, the woman mused. She did not wish to see her married to a man who labored in a field; but it would be delicious to see her love him and hating herself for it, fighting a rosy battle with her heart. There was no romance in loving an "available" man; there was no suffering in it, and how empty was a love that did not swallow a midnight sob! She asked Gunhild to walk out into the woods with her. They crossed a low, marshy place where pickerel split the trashy water in the spring of the year, and strolled up a <DW72> into the woods. They gathered flowers, talking of things that interested neither of them; they found an old log covered with moss and here they sat down to rest. It was always sad to feel that the summer would soon be gone, the elderly woman said, gazing at a soldierly mullein stalk, nodding its yellow head. More summers were coming, and the leaves and the flowers would be the same, the grass as green, the birds as full of happy life; but the heart could not be turned back to live over the hours and the days--only, in dreaming, in reminders of the time forever gone. To the youthful, two summers are twins; to the older, they are relatives; to the aged, strangers. "You make me sad when you talk that way," said the girl. "My dear child, a sadness to-day may be food for sweet reflection in the future. Indeed, it would even be well for you to suffer now." "But I do not want to suffer. I do not see the need of it." "My dear, suffering prepares us for the better life. It makes us more thankful." "I do not know that," she said with energy. "Sometimes it may harden us. We may be kept from food so long that we have no manners when we come to the table." "Gunhild, that is a very good remark--a thoughtful remark, true in the main, but not illustrative of the point I wish to make. But you are so full of hope that--" "Full of hope, madam?" "Yes, the hope that rises from health and strength. You have so much to look forward to. You might make a brilliant match." "Then I must hope that sometime I may sell myself?" "Oh, no, no. I didn't mean that. I mean that you have prospects. Shall I be plain? You have the prospects of loving one man and marrying another. That is called a brilliant match, I believe. Or, at least, it is a feature of nearly all brilliant matches. Don't you think so?" "I am not supposed to know, madam." "Not even to please me?" "Oh, if it please you, I am supposed to know everything." "Good. Then tell me what you know about Mr. Milford. You understand that it is my mission to find interest in nearly all--well, I might say, odd persons. You have met him when I was not with you. And he must have told you something." "He has told me nothing that I can repeat." "Oh, is it that bad?" "Is what that bad, Mrs. Goodwin? I do not understand what you mean by that bad. Perhaps what he told me did not make enough impression to be remembered." "But didn't he say things you did not remember, but continued to feel?" "Yes, I believe so. You know that I do not understand men very well. I do not understand any one very well. They make remarks about him and say that he is mysterious, but he is plainer to me than any one. Somehow I feel with him. He has had a hard life, I think, and that brings him closer to me." "Ah, my dear, the suffering I spoke of just now." "But," the girl added, "I do not know that his hard life has made him any better." "Perhaps not. But it must have made him more thoughtful. After all, I'm not so much interested in him. He is one of the characters that throw a side-light on our lives. He can never take an essential part in our affairs. Do you think so?" "I must again say that I do not understand." "Why, don't you know that we meet many persons, and become quite well acquainted with them, and yet never feel that they belong to our atmosphere? They are not necessary to the story of our lives, so to speak, and yet that atmosphere of which they are not really a part, would not be wholly complete without them. They stand ready for our side talks; sometimes they even flip a sentiment at us. We catch it, trim it with ribbons and hand it back. They keep it; we forget. The Blakemores are such persons. We may never see them again--may almost wholly forget them, and yet something that we have said may influence their lives. And perhaps to Mr. Milford, we are but side-lights. He may soon be in his saddle again, forgetting that he ever knew us. But are we to forget him? Has his light been strong enough
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ities were women. The etiology of this change, and the question of why it should happen so soon after the end of the Journey, is still a puzzle. Of the other "matriarchal" or female-oriented species in the galaxy (some seventy-five percent), only one other, the Bhvui, has done anything similar, and the histories of the two species are too different to make comparisons meaningful. But in any case, Rihanssu woman warriors have become almost as much of a legend as pre-Reformation Vulcan, and there are countless gossipy stories of "Romulan"-dominated worlds ruled by suave and sophisticated warrior princesses with harems full of good-looking men. The only thing to be said about these stories is, if they were true, the Rihannsu would not have had to enter into so many destructive deals with the Klingons to keep their economy afloat. They could have done quite nicely from the female tourist trade. But again, these developments were in the future. The eighteen thousand remaining Travelers slowly left the ships over some three years, cautiously establishing support bases for themselves, until there were very few people still living in the ships. Some did choose to remain, mostly those people who had become agoraphobic over the long journey, or had been born in the ships and wanted nothing to do with open skies and planets. The Ship-Clans, as they came to be known, lived quite happily aboard their great echoing homes, looking down on the Two Worlds around which they coasted in asynchronous orbits. The ships were resupplied and repaired over some years from planetary resources: people would return to the ships for holidays, out of nostalgia or curiosity. Over many more years this sort of thing came to an end, as the population turned over and there was no one left who had been born on Vulcan, or on shipboard during the Journey. The long run through interstellar night became something sung about, but not a thing anyone wanted to have experienced. Ch'Rihan and ch'Havran were the real worlds now, not those ancient ones with metal walls and skies that echoed. Though they slowly dwindled, the Ship-Clans maintained the four ships of the Journey, and evening and morning they could be seen low above the planets' horizons, bright points in the sky. They did not stay there forever. Some hundreds of years later, due to neglect, government squabbles, economic troubles, and war, one at a time the stars fell: and the Two Worlds orbited Eisn, their "Homesun," cut off from the rest of the universe in the beginning of their long isolation. It was an unfortunate paradigm for the loss of sciences and technologies that began during that time and would continue for a thousand years to come. But the songs of the Rihannsu still recall the evening stars at sunset, and the breath of wind in trees, and the love of starlight seen through evening rather than through the hard black of space. "The Journey is noble," said one bard's song, "and adventure and danger is sweet, but the wine by the fireside is sweeter, and knowing one's place." # Chapter Seven H'DAEN TR'KHELLIAN WAS gazing out of the antechamber window when Arrhae came in to answer his summons. He didn't turn around, merely twisted somewhat and watched over his shoulder as she gave him the customary obeisance. He looked thoughtful and somewhat ill at ease. "Fair day, _hru'hfirh_ ," she said as usual, straightening. "After a poor night." H'daen looked her full in the face, as if searching for something that might give him an answer before he had to ask any questions aloud. Apparently he saw nothing, and shrugged. "Arrhae, is there truth in what I hear of you and Maiek tr'Annhwi?" "My lord?" Arrhae had no need to pretend surprise. She knew that one of H'daen's body-servants was on intimate terms with Ekkhae, who had been among those cleaning the dining-chamber last night, but she hadn't expected the gossip to travel quite so fast as this. Nor had she expected anyone to give credence to it. "The Subcommander sought me out before he left, and apologized at some length for his behavior. Then he asked if he was forgiven, if he would be permitted to enter my house again—and if I granted him the right to visit you. He told me that you wanted him to speak on this matter." H'daen crossed the room and sat down at his desk, pouring himself a cup of wine rather than asking her to do it. He had been drinking more of late, and earlier in the day, but with Eisn not yet clear of the horizon this cupful was more a continuation of last night's drinking than a new day's start. He swallowed perhaps half the cupful and refilled it before saying any more, and when he turned to face her again, his face was troubled. "It was my impression that you already visited with Lhaesl tr'Khev. Was I mistaken?" Arrhae lowered her eyes uncomfortably. Lhaesl hadn't yet been officially snubbed, and was either too enamored or too dense to realize of his own accord that she had no interest in him. Granted that they were physically of an age, the differing metabolism of Rihannsu and Terran—no matter how accurately that Terran might be disguised—still meant that his twenty-eight and hers left him at a behavioral equivalent of fifteen. A pretty child, but a child for all that. "Tr'Khev visits me, lord. I do not encourage him; and though I should, I have not yet discouraged him in whatever way it needs for him to understand." "Oh. Thank you. The situation becomes clearer, Arrhae. Then I was right in what I told tr'Annhwi." "Told him... ?" "That he could visit with you, that you were a free woman and one with a mind of your own, and that he would learn soon enough if he wasn't welcome." Arrhae barely kept the strangulated squeak of horror in her throat, when what it really wanted to do was leap out as a full-fledged yell of _You old fool!!_ Two days ago she wouldn't even have considered addressing the Head of House in any such fashion, but then, two days ago, she had almost forgotten who she was and what had brought her here. "And if I choose not to make him welcome, lord?" she wondered tentatively. "I would prefer that you did, Arrhae." _"Prefer" indeed! That was an order_. _I wonder why?_ She watched him, but said nothing. "House Annhwi is strong, wealthy, and well-placed—" _Question answered_. "—and the Subcommander's friendship would prove an asset to House Khellian. Arrhae, sit down. Fill my cup again and... and pour a cup for yourself." The invitation was so out of place that Arrhae felt her face burn hot. "Lord, I am _hru'hfe_ only, and—" H'daen raised one finger and she was silent. "You are _hru'hfe_ indeed, and a worthy ornament to this house, honored by its guests. Why wonder, then, that I bid you drink with me out of respect for that honor which reflects so well on me and on my House? Sit, Arrhae, and drink deep." She sat down straight-backed, most uncomfortable with the situation but aware of being closely watched, and determinedly did as she was told. Expecting something rough as ale, Arrhae found the wine so much smoother and of better flavor that she put her mouthful down at a single gulp, then grimaced and felt tears prickle at her eyes as the liquid revealed itself correspondingly stronger—when the swallow had passed the point of no return. H'daen smiled thinly but without any malice. "It takes everyone that way the first time they drink it. Even me. Now, again. It won't be such a shock; you might even start to like it." He was right. Arrhae managed to down her second mouthful without spluttering, and actually enjoyed the small fusion furnace that came to life in the pit of her stomach. As for the rest of it, she set the cup down carefully and began to turn it around and around, watching the pretty sparkling of the reflec glaze. She would have watched moisture condense on glass, or paint dry—just so long as she didn't have to watch H'daen's eyes on her. At the back of her mind there was a suspicion, no matter how unfounded it might be, that H'daen might be trying to make her drunk in order to pry secrets from her. Only great caution would avoid that; she would appear to drink as she was expected to do, without absorbing any of the powerful toxins in the wine. Yet H'daen himself was drinking without restraint, and the first and last rule of making someone drunk to loosen their tongue was not to get drunk first. He was on his third cupful now, and no matter how accustomed one might be to the potent liquor, immunity was a different matter. It wasn't as if he were drinking from another jug
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in which one Scot—possibly himself, as he tended to narrate personal anecdotes in the third person—was required to show devotion to a picture of the Virgin Mary. The prisoner was told to give it a kiss of veneration. He refused and when the picture was pushed up to his face, the prisoner seized the picture and threw it into the sea, saying, "Let our Lady now save herself: she is light enough: let her learn to swim." After that, according to Knox, the Scottish prisoners were no longer forced to perform such devotions. In summer 1548, the galleys returned to Scotland to scout for English ships. Knox's health was now at its lowest point due to the severity of his confinement. He was ill with a fever and others on the ship were afraid for his life. Even in this state, Knox recalled, his mind remained sharp and he comforted his fellow prisoners with hopes of release. While the ships were lying offshore between St Andrews and Dundee, the spires of the parish church where he preached appeared in view. James Balfour, a fellow prisoner, asked Knox whether he recognised the landmark. He replied that he knew it well, recognising the steeple of the place where he first preached and he declared that he would not die until he had preached there again. In February 1549, after spending a total of 19 months in the galley-prison, Knox was released. It is uncertain how he obtained his liberty. Later in the year, Henry II arranged with Edward VI of England the release of all remaining Castilian prisoners. Exile in England, 1549–1554 On his release, Knox took refuge in England. The Reformation in England was a less radical movement than its Continental counterparts, but there was a definite breach with Rome. The Archbishop of Canterbury, Thomas Cranmer, and the regent of King Edward VI, the Duke of Somerset, were decidedly Protestant-minded. However, much work remained to bring reformed ideas to the clergy and to the people. On 7 April 1549, Knox was licensed to work in the Church of England. His first commission was in Berwick-upon-Tweed. He was obliged to use the recently released Book of Common Prayer, which maintained the structure of the Sarum Rite while adapting the content to the doctrine of the reformed Church of England. Knox, however, modified its use to accord with the doctrinal emphases of the Continental reformers. In the pulpit he preached Protestant doctrines with great effect as his congregation grew. In England, Knox met his wife, Margery Bowes (died ). Her father, Richard Bowes (died 1558), was a descendant of an old Durham family and her mother, Elizabeth Aske, was an heiress of a Yorkshire family, the Askes of Richmondshire. Elizabeth Bowes presumably met Knox when he was employed in Berwick. Several letters reveal a close friendship between them. It is not recorded when Knox married Margery Bowes. Knox attempted to obtain the consent of the Bowes family, but her father and her brother Robert Bowes were opposed to the marriage. Towards the end of 1550, Knox was appointed a preacher of St Nicholas' Church in Newcastle upon Tyne. The following year he was appointed one of the six royal chaplains serving the King. On 16 October 1551, John Dudley, 1st Duke of Northumberland, overthrew the Duke of Somerset to become the new regent of the young King. Knox condemned the coup d'état in a sermon on All Saints Day. When Dudley visited Newcastle and listened to his preaching in June 1552, he had mixed feelings about the fire-brand preacher, but he saw Knox as a potential asset. Knox was asked to come to London to preach before the Court. In his first sermon, he advocated a change for the second edition of the Book of Common Prayer. The liturgy required worshippers to kneel during communion. Knox and the other chaplains considered this to be idolatry. It triggered a debate where Archbishop Cranmer was called upon to defend the practice. The end result was a compromise in which the famous Black Rubric, which declared that no adoration is intended while kneeling, was included in the second edition. Soon afterwards, Dudley, who saw Knox as a useful political tool, offered him the bishopric of Rochester. Knox refused, and he returned to Newcastle. On 2 February 1553 Cranmer was ordered to appoint Knox as vicar of All Hallows, Bread Street in London, placing him under the authority of the Bishop of London, Nicholas Ridley. Knox returned to London in order to deliver a sermon before the King and the Court during Lent and he again refused to take the assigned post. Knox was then told to preach in Buckinghamshire and he remained there until Edward's death on 6 July. Edward's successor, Mary Tudor, re-established Roman Catholicism in England and restored the Mass in all the churches. With the country no longer safe for Protestant preachers, Knox left for the Continent in January 1554 on the advice of friends. On the eve of his flight, he wrote: Sometime I have thought that impossible it had been, so to have removed my affection from the realm of Scotland, that any realm or nation could have been equal dear to me. But God I take to record in my conscience, that the troubles present (and appearing to be) in the realm of England are double more dolorous unto my heart than ever were the troubles of Scotland. From Geneva to Frankfurt and Scotland, 1554–1556 Knox disembarked in Dieppe, France, and continued to Geneva, where John Calvin had established his authority. When Knox arrived Calvin was in a difficult position. He had recently prosecuted the execution of the scholar Michael Servetus for heresy. Knox asked Calvin four difficult political questions: whether a minor could rule by divine right, whether a female could rule and transfer sovereignty to her husband, whether people should obey ungodly or idolatrous rulers, and what party godly persons should follow if they resisted an idolatrous ruler. Calvin gave cautious replies and referred him to the Swiss reformer Heinrich Bullinger in Zürich. Bullinger's responses were equally cautious; but Knox had already made up his mind. On 20 July 1554, he published a pamphlet attacking Mary Tudor and the bishops who had brought her to the throne. He also attacked the Holy Roman Emperor, Charles V, calling him "no less enemy to Christ than was Nero". In a letter dated 24 September 1554, Knox received an invitation from a congregation of English exiles in Frankfurt to become one of their ministers. He accepted the call with Calvin's blessing. But no sooner had he arrived than he found himself in a conflict. The first set of refugees to arrive in Frankfurt had subscribed to a reformed liturgy and used a modified version of the Book of Common Prayer. More recently arrived refugees, however, including Edmund Grindal, the future Archbishop of Canterbury, favoured a stricter application of the book. When Knox and a supporting colleague, William Whittingham, wrote to Calvin for advice, they were told to avoid contention. Knox therefore agreed on a temporary order of service based on a compromise between the two sides. This delicate balance was disturbed when a new batch of refugees arrived that included Richard Cox, one of the principal authors of the Book of Common Prayer. Cox brought Knox's pamphlet attacking the emperor to the attention of the Frankfurt authorities, who advised that Knox leave. His departure from Frankfurt on 26 March 1555 marked his final breach with the Church of England. After his return to Geneva, Knox was chosen to be the minister at a new place of worship petitioned from Calvin. In the meantime, Elizabeth Bowes wrote to Knox, asking him to return to Margery in Scotland, which he did at the end of August. Despite initial doubts about the state of the Reformation in Scotland, Knox found the country significantly changed since he was carried off in the galley in 1547. When he toured various parts of Scotland preaching the reformed doctrines and liturgy, he was welcomed by many of the nobility including two future regents of Scotland, the Earl of Moray and the Earl of Mar. Though the Queen Regent, Mary of Guise, made no move against Knox, his activities caused concern among the church authorities. The bishops of Scotland viewed him as a threat to their authority and summoned him to appear in Edinburgh on 15 May 1556. He was accompanied to the trial by so many influential persons that the bishops decided to call the hearing off. Knox was now free to preach openly in Edinburgh. William Keith, the Earl Marischal, was impressed and urged Knox to write to the Queen Regent. Knox's unusually respectful letter urged her to support the Reformation and overthrow the church hierarchy. Queen Mary took the letter as a joke and ignored it. Return to Geneva, 1556–1559 Shortly after Knox sent the letter to the Queen Regent, he suddenly announced that he felt his duty was to return to Geneva. In the previous year on 1 November 1555, the congregation in Geneva had elected Knox as their minister and he decided to take up the post. He wrote a final letter of advice to his supporters and left Scotland with his wife and mother-in-law. He arrived in Geneva on 13 September 1556. For the next two years, he lived a happy life in Geneva. He recommended Geneva to his friends in England as the best place of asylum for Protestants. In one letter he wrote: I neither fear nor eschame to say, is the most perfect school of Christ that ever was in the earth since the days
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512, 673, 2792, 313, 17, 13, 374, 13, 608, 13, 285, 1903, 1107, 10, 285, 19427, 323, 40295, 257, 4868, 387, 8245, 13, 253, 10005, 273, 40295, 257, 4868, 24315, 10126, 3012, 875, 253, 2390, 2796, 49, 13912, 470, 15, 21940, 13, 323, 6865, 14, 1615, 14, 6998, 5016, 1055, 582, 342, 253, 36121, 14, 51, 1934, 80, 1387, 1907, 327, 3388, 2406, 10005, 2796, 49, 16160, 470, 15, 2874, 13, 323, 5901, 14, 15131, 10, 313, 2841, 544, 19, 66, 1084, 39, 19, 910, 709, 14, 881, 568, 926, 2536, 496, 271, 6960, 21535, 9077, 1783, 13, 253, 6070, 273, 6036, 14, 11747, 486, 10005, 275, 3564, 285, 4669, 387, 1903, 1107, 369, 8131, 407, 253, 3361, 273, 6658, 38890, 2803, 387, 8245, 285, 407, 253, 2014, 14, 21272, 5700, 323, 253, 806, 374, 1107, 313, 3235, 544, 18, 1084, 53, 18, 910, 709, 14, 881, 568, 2420, 2536, 187, 187, 5146, 2490, 187, 3980, 3466, 21535, 9077, 1783, 323, 8188, 9522, 10005, 387, 1903, 1107, 535, 50276, 23807, 387, 8245, 50254, 40953, 1397, 4313, 313, 2222, 6, 7309, 10, 50275, 11, 49, 11, 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14, 2307, 5411, 1331, 343, 248, 18266, 5835, 313, 9042, 10449, 84, 10, 390, 247, 2014, 11085, 10449, 313, 47307, 1843, 4846, 15, 11357, 66, 4846, 688, 4686, 403, 253, 5705, 11691, 387, 1903, 1107, 313, 9389, 1363, 275, 1016, 1387, 858, 417, 452, 7363, 387, 608, 1107, 481, 23409, 403, 4469, 347, 253, 1599, 285, 5325, 6, 7162, 7726, 15, 11357, 67, 4846, 510, 1599, 2544, 275, 40295, 257, 4868, 1309, 1107, 470, 281, 374, 13, 374, 281, 608, 13, 285, 608, 281, 1903, 13, 2556, 281, 253, 3302, 1971, 2390, 5774, 274, 1229, 1549, 14, 19, 4253, 39, 19, 94, 187, 187, 510, 18934, 1599, 1818, 432, 8245, 281, 1903, 1107, 275, 40295, 257, 4868, 369, 884, 313, 2222, 6, 7309, 13, 721, 281, 1668, 10, 275, 1363, 665, 574, 644, 275, 31701, 387, 337, 807, 285, 2030, 313, 2222, 6, 7309, 13, 3127, 281, 4562, 10, 275, 1363, 665, 574, 417, 644, 275, 31701, 387, 337, 807, 2796, 49, 13912, 470, 15, 2874, 481, 2091, 970, 512, 673, 2792, 313, 17, 13, 374, 13, 608, 13, 285, 1903, 1107, 10, 285, 19427, 323, 40295, 257, 4868, 387, 8245, 13, 253, 10005, 273, 40295, 257, 4868, 24315, 10126, 3012, 875, 253, 1363, 275, 31701, 285, 417, 275, 31701, 387, 337, 807, 2796, 49, 16160, 470, 15 ]
11 years. Materials and methods ===================== Patients -------- From April 1993 to May 1995, 199 DMARD-naïve patients with recent-onset RA were admitted to this randomized study comparing the efficacy and tolerability of treatment with either a combination of DMARDs (starting with methotrexate, sulfasalazine, and hydroxychloroquine with prednisolone; FIN-RACo strategy) or a single DMARD (initially sulfasalazine with or without prednisolone; SINGLE strategy). The treatment was targeted toward remission in all patients. After 2 years, the treatment of RA was unrestricted, but still aiming at remission. Thus, regardless of the original randomization group, the patients could be treated liberally with DMARDs, biologic agents, glucocorticoids, and with their combinations, as clinically indicated and tolerated. Conversely, in long-term remission the protocol required drug doses to be reduced and eventually tapered off. The patient-selection criteria and the study design were described in detail earlier \[[@B3],[@B10],[@B11]\]. ### Radiologic assessment Hands and feet of all patients were radiographed at baseline and at 2, 5, and 11 years. Hip, knee, elbow, and shoulder joints of the patients were radiographed at 11 years in 13 study centers; in two study centers, only clinically symptomatic large joints were radiographed. Total joint replacements were counted from the radiographs as well as from the patients\' medical records. The radiographs were assessed by the same experienced radiologist (LL), who was blinded to the clinical data but aware of the order of the radiographs. The radiographs of hands and feet were scored according to the method of Larsen *et al.*\[[@B12]\], with a range from 0 to 200. The large joints were also scored according to the method of Larsen \[[@B12]\], and a score of ≥2 was considered to indicate erosive disease. Clinical assessments were performed by the treating rheumatologist. DMARD strategies used between years 2 and 11 were carefully elucidated based on the patient\'s self-report and his or her medical records \[[@B11]\]. Ethical considerations ---------------------- The study was performed according to the principles of the Declaration of Helsinki. The protocol was approved by the national health authorities and ethics committees in all 18 participating hospitals. All patients gave written informed consent. Statistical methods ------------------- The data are presented as means with standard deviations (SDs), medians with interquartile ranges (IQRs), or counts with percentages. Statistical comparison between groups was made by *t*test, permutation test, χ^2^test, or the Fisher Exact test, when appropriate. The 95% confidence intervals (95% CIs) for the Larsen score are obtained by bias-corrected bootstrapping due to the skewed distribution. The difference in crude changes in Larsen score between the groups was tested by a permutation test. A random coefficient model with bootstrapped standard errors was adapted to analyze the progression of the Larsen score during 11 years and to compare the groups in time. An ordered logistic regression analysis was used to estimate the prediction of achieving radiologic progression. The adjusted risk ratio (RR) between the groups for having no erosive changes in large joints was estimated by a generalized linear model (log link), with presence of erosion in hands or feet at baseline as covariate. A time-to-event analysis based on the product-limit estimate of the cumulative \"survival\" function (Kaplan-Meier) was used to describe the time to the first total joint replacement. A log-rank test was used to identify any survival difference between the groups. Results ======= Of the 199 patients originally randomized to the study, 195 started treatment, 97 in the FIN-RACo group, and 98, in the SINGLE group. At the 11-year visit, 68 patients were assessed in the FIN-RACo group, and 70, in the SINGLE group; the patients\' baseline demographic and clinical characteristics were comparable \[[@B11]\]. In total, 130 patients had radiographs of hands and feet available at baseline and at 11 years, 65 cases in each group. A trend toward a higher mean (range) Larsen score at baseline was found in the SINGLE group compared with the FIN-RACo group: 5 (0 to 30) versus 3 (0 to 25) (*P*= 0.069). Furthermore, the dropout cases in the FIN-RACo group had a higher mean ± SD Larsen score at baseline than did the completers: 6 ± 9 versus 3 ± 6 (*P*= 0.037). In the SINGLE group, the baseline Larsen scores did not differ between the dropouts and the completers: 3 ± 5 versus 5 ± 7 (*P*= 0.22). The cumulative percentages of Larsen scores in both groups are shown in Figure [1](#F1){ref-type="fig"}. One outlier in the FIN-RACo group had progressed to almost a maximum score after 11 years. Despite active combination DMARD treatment, this patient had had high disease activity and HAQ score throughout the follow-up, and by 11 years, also had damage in large joints as well as one total joint replacement. ![**The cumulative percentage of increase in Larsen score from baseline to 11 years in patients initially randomized to receive a combination (FIN-RACo) of disease-modifying antirheumatic drugs (DMARDs) or a single DMARD (SINGLE)**.](ar3060-1){#F1} The mean Larsen scores of hands and feet at baseline and at 2, 5, and 11 years in both groups are shown in Figure [2](#F2){ref-type="fig"}. The crude mean change from baseline to 11 years in Larsen score was 17 (95% CI, 12 to 26) in the FIN-RACo group and 27 (95% CI, 22 to 33) in the SINGLE group (*P*= 0.037). When using all time points (0, 2, 5, and 11 years) and adjusting for Larsen score at baseline, the progression of Larsen score differed statistically significantly between the groups (*P*= 0.021, for Time-by-Group interaction effect), with the FIN-RACo group having on average lower progression (*P*\< 0.001, for Group-Effect) (Figure [2a](#F2){ref-type="fig"}). In an ordered logistic regression analysis, the extent of joint-damage progression in hands and feet at 11 years was predicted by the presence of serum rheumatoid factor at baseline and by the single-treatment strategy for the first 2 years (Table [1](#T1){ref-type="table"}). ###### Ordered logistic regression analysis for radiologic progression at 11 years Variable at baseline Odds ratio (95% CI) *P*value ------------------------------------------- --------------------- ---------- Female sex 1.74 (0.84 to 3.60) 0.13 Age, years 0.99 (0.96 to 1.02) 0.60 Disease duration before diagnosis, months 1.02 (0.94 to 1.10) 0.68 Rheumatoid factor positivity 3.17 (1.45 to 6.92) 0.004 Erythrocyte sedimentation rate 1.01 (0.99 to 1.02) 0.33 Larsen score 0.99 (0.94 to 1.05) 0.77 Initial randomization group 0.016 FIN-RACo 1.00 (reference) SINGLE 2.39 (1.78 to 4.84) Radiologic progression in hands and feet was determined according to the tertiles of Larsen score changes (categories 0 to 1, 2 to 17, and ≥18). FIN-RACo, study group treated for the first 2 years with a combination of three disease-modifying antirheumatic drugs, initially methotrexate, sulfasalazine, and hydroxychloroquine, with prednisolone; SINGLE, study group treated for the first 2 years with one disease-modifying antirheumatic drug, initially sulfasalazine, with or without prednisolone. ![**The crude mean Larsen scores of hands and feet at baseline and at 2, 5, and 11 years in patients initially randomized to receive a combination (FIN-RACo) of disease-modifying antirheumatic drugs (DMARDs) or a single DMARD (SINGLE)**. **(a)**Included are the subjects scored at 11 years (two patients in each group did not have scores at 5 years). Values are expressed as the mean and 95% confidence interval. **(b)**The mean changes in Larsen score during years 0 to 2, 2 to 5, and 5 to 11, according to the initial treatment groups.](ar3060-2){#F2} The crude mean change from baseline to 11 years in Larsen score was 10 (95% CI, 6 to 16) in patients who had been in remission at 1 year and 25 (95% CI, 21 to 31) in patients who had not been in remission at 1 year (*P*= 0.001). When using all time points (0, 2, 5, and 11 years) and adjusting for Larsen score at baseline, the progression of Larsen score differed statistically significantly between the patients in remission and not in remission at 1 year (*P*\< 0.
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'd rather talk to you. There are things we need to discuss." "I don't agree." With another smile and a flourish of his blue coat, he sank down on the worn bench. He leaned back and folded his arms across his chest. "Well, we can talk now. I'm at leisure." She cast him a killing look under her thick tawny lashes, but he knew that for once he had all the advantages. She'd want complete privacy for the coming interview, even if she intended to reveal nothing. His indiscreet questions could stir up trouble in this quiet retreat. "I curse the day I met you," she said, with real feeling. Her mouth was tense with displeasure and the small mole on her cheek stood out on her white skin like a dark beacon. He let his smile widen. "Don't think if you're nice to me you'll cajole me into letting you off the hook." "I'm not a salmon, Erith," she said icily. "I'll see you in the village in an hour. If you're not outside the inn, I'll leave without you. And you and your threats can go to Hades." With an irritated swish of her skirts, she stalked toward the rectory. Erith watched her go, as always admiring the subtle curves of her hips and the grace of her carriage. Annoyance added a swing to her gait. He liked it. It was closer to an hour and a half later when the black coach pulled up outside the village's pathetic excuse for a hostelry. Olivia hadn't exaggerated when she'd called it a poor place. Erith had endured an awkward hour in the filthy taproom drinking watery beer while lumpen yokels stared at him in vacant wonder. After the hour was up, he'd been pleased to go out and wait in the sunshine with Bey. Although the spectacular horse created even more stir among the locals than an earl had inside the dingy inn. His discomfort wasn't purely a result of the unwelcome attention he received in the village. In this obscure corner of the kingdom, the smells and sights and sounds of rural England surrounded him. On the ride down he'd been too angry to notice the burgeoning green around him. He hadn't been in the English countryside for years, probably since the days of his marriage. He'd forgotten the sweet, blossoming poignancy of spring. He'd forgotten how lush the fields were. He'd forgotten the rich smell of English crops growing in English soil. As a young man he'd wanted nothing more than to run his estates and grow old on the lands his father bequeathed to him. Then Joanna died and his life twisted away from its safe, comfortable shape. Strange, he hadn't realized how much he'd missed the familiar countryside. And he had missed it, with a depth of painful longing he only now recognized. Olivia's coachman climbed down and fought his way through the crowd of filthy urchins to take Bey's reins. "Shall I tie him to the back of the carriage, my lord?" "Yes." Erith strode toward the vehicle. He'd thought he might have to trample the little ruffians, but they recognized his authority and swerved out of his way. He swung the door open and climbed inside. As he'd expected, the conveyance was the latest word in luxury, from the ruby red Morocco leather seats to the tasseled silk cushions and gleaming wood fittings. He took his place with his back to the horses and looked speculatively across to where his mistress sat in mute elegance in the opposite corner. After the bright sunlight outside, she was a creature of shadows. He felt her eyes on him as he settled, stretching his legs out across the well between the seats and resting his broad shoulders against the upholstery. She was dressed for town again, in the fashionable bonnet and gloves. She seemed a subtly different woman from the virago who had confronted him beside the pond. But today he'd seen too much to believe that only the cold courtesan existed inside her. For all Olivia's outward calm, he could smell the tension under her sweet floral scent. She braced for his attack like a trapped antelope waiting for the lion to spring. The savage lurking inside him wanted nothing more than to seize her in his arms and kiss that stern mouth into softness. The enforced intimacy of the coach reminded him he was yet to lose himself in her spare, glorious body. He tried to ignore the animal side of his nature. But it was difficult when she was so close. "You're late," he said, as much to pierce the silence as to chastise her. "Yes." Her voice was clipped. She was still angry. Perhaps even angrier than before, now that she didn't fear for Leonidas and there were no witnesses to their confrontation. She didn't need to tell Erith that she'd deliberately delayed picking him up. Had she imagined if she was late, he'd go without her? What did the wench think? That his noble dignity wouldn't extend to waiting half an hour? She underestimated both his patience and his curiosity. The carriage lurched into motion, and he watched her lift one slender arm to grip the leather strap for balance. Aha, my lady, I'm going to put you off balance and keep you that way. He spread his arms along the back of the seat, settling himself into the coach's rocking motion. His appearance of relaxation would rile her. His eyes had adjusted to the gloom, and he read the cool rejection in her striking features. The air was thick with everything unspoken between them. He had no difficulty divining Olivia's strategy. She meant to freeze him into silence and keep him that way until they reached London and the announcement she would remove herself to Lord Peregrine's town house forthwith. With perhaps one final plea to keep what he'd discovered today to himself. Unfortunately for her, his plans were different. And his plans would prevail. He drew a deep breath and launched his attack. "Leonidas Wentworth is your son." ## Chapter 10 As Erith flung the uncompromising words at her, Olivia flinched and her face turned pale as moonlight. She snatched her hand from the strap to press it trembling against her breast. Her shock and fear were unmistakable. In the charged silence that followed his statement, he wondered if she meant to lie and deny what he'd said. He should have known better. He heard her draw in a shuddering breath. She raised her chin and spoke defiantly. "Yes." Her expression was cold and closed. Her full lips took on a tense line and the gloved hand she held to her chest formed a fist. She bristled with hostility so powerful, it was almost tangible in the close confines of the carriage. He sharply regretted that when he pried into her secrets, he hurt her. But while he waited in the village, he'd had time to ponder today's revelations. If he was to help her, he needed to know what had happened in her past and what he could do to gain long-delayed justice. Ever since that jagged moment when he'd realized Leo was her son, a roiling mess of conflicting emotions had churned in Erith's gut. Amazement. Appalled outrage. Protectiveness. Sorrow. A voracious hunger for vengeance. Curiosity that burned like acid. "You must have been little more than a child when you bore him." His tone remained austere although he could hardly bear to imagine what she'd endured. He was afraid that if he loosened the ruthlessly tight rein on his rage and grief, he'd lash out and terrify her indeed. Even though none of his anger was directed at her. Good God, how could it be? "How old are you now? Thirty?" "Thirty-one," she snapped. Older than he'd thought. But in any just world, far too young to have a son of nearly adult age. "And he's what? Sixteen? Seventeen?" The boy's lanky height had originally fooled Erith into thinking him a few years older. Not surprising first impressions led him astray. Erith had observed the youth from yards away and through the distorting mirror of a virulent jealousy he still cringed to admit. Leo didn't resemble his mother in much except for a slight lordliness to his manner. And that intense pride. The same pride he saw in Olivia now as she sat opposite him, spine ruler straight, eyes blazing, chin up. "This is none of your concern, my lord." Her voice was as icy and cutting as sleet on a windy winter moor. The frail intimacy they'd established in the last few days might never have existed. She built a high wall around herself, invisible but real as the leather-covered seat beneath him. Unluckily for her, he intended to lay siege to her defenses. Batter them down if need be. "I make it my concern." Sighing, he ran one hand through his hair. He desperately hoped his motives weren't entirely selfish. He didn't think so. His voice softened. "I know you're stubborn, Olivia. After what I've learned today, I suspect you've had to be. But humor me in this."
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I just realized: I've played more Pokemon White than any friggen game in my collection. 300+ hours and I'm still not getting bored of it. It also made me think: why does no other game have replay value of this magnitude? I played and beat Mario Kart 7 and tried to get into it, but I realized how horribly flawed this whole game is: you are bombarded with car-stopping items, and Wi-fi is the biggest load of crap: players literally WARP to the end of the track. The more I play it, the more I hate it. Pokemon, on the other hand, has the potential of raising over 640 Pokemon, and I feel the potential to train them all to their best potential. And then I feel like training multiple ones of each for different teams, and the Pokemon themselves become inspirations for me and my artwork, and help me with character development/form/size, etc. This game has also helped me make some very good friends. Thanks to this game, I really can't enjoy any other game anymore. My standards on games have also changed too: often ask myself if I'm really going to be playing this game for years on end. I can only apply to that to, like 10 of the 200+ games I own. I don't know how I'm coming to this today, I just feel like I'm not enjoying games that much: the bonus content just doesn't seem engaging to me anymore. This is sort of true. I mean the game is just 10 hours (maybe more.), Story is bland (Young kid embarks on a journey to become a Pokemon master, must collect Pokemon data along the way, fights rival, foils the plan of a evil crime syndicate that was planning on using a legendary Pokemon to rule the world, Kid becomes Pokemon Master. Wash, Rinse, Repeat.), the turn-based battles get boring really fast (the whole game is based around a complex paper, scissor, rock mechanic.) You only really need to level up your main 6 Pokemon (Seriously.), you only need at least 3 Pokemon (one that knows how to surf, fly, use cut, can break boulders, use rockclimb, can cross whirlpools, can go up waterfalls, etc., etc.. You can teach these moves to one of your starters, and all you need to do is capture a flying type.), you don't need the legendary Pokemon (They are banned in any Pokemon event, they are pointless, basically trophies.), the most recent designs are really uninspired (no comment), once you beat the game twice, there's really not much to do. Nintendo should really step it's game up. Pokemon Black/White was the game that made me realize how tedious and boring Pokemon games are starting to get. I played and beat Mario Kart 7 and tried to get into it, but I realized how horribly flawed this whole game is: you are bombarded with car-stopping items, and Wi-fi is the biggest load of crap: players literally WARP to the end of the track. The more I play it, the more I hate it. it's one track with the warping glitch (and it wouldn't surprise me if Nintendo were able to fix it somehow). you can easily avoid it by playing in trusted communities, with friends, or by making sure to not pick Maka Wuhu while playing Worldwide (as opposed to randomizing). if it still comes up, you can either play it through (it's a great track) or force a d/c by going the wrong way; whichever floats your boat. Also, idk what MK games you've been playing, but Mario Kart has always been about bombarding other players with car-stopping items. learning to avoid them takes practice. if you prefer Pokemon to Mario Kart, that's fine, but don't blame the game for your own hangups. the good news for you is that MK7 will probably trade in for a fat chunk of store credit if you want to go that route, or you can probably eBay it for full retail price if you prefer. Pokemon games, not so much :3 BEST THREAD EVERfuture of NL >:3 [16:43] James: I should learn these site rules more clearly [16:44] LztheBlehBird: James doesn't know the rules? For shame!!! [16:44] Vintage: We have rules? [16:44] Reala: don't expose the staff to sunlight, don't get them wet and don't feed them after midnight Everyone has their own thing... To me, I like Pokemon, but it didn't ruin other games for me. Just because I have 400+ hours in some Pokemon games doesn't mean I abandoned all my other games. I have to be in certain moods to play certain games... i like challenging games. games that i can restart on and have just as much fun it even if i remember every detail of the storyline. Pokemon, not challenging. Dragon Quest IX, somewhat challenging. Portal 2 OMFG I LOVE YOU. While portal 2 was a great game and technically shouldn't have much replay value if you remember the puzzles, i love replaying it because the story is loose enough. There is more focus on the game play than the story. I can't tell if im explaining this right, maybe im just a babbling buffoon. If you like Pokémon, why don't you try Dragon Quest Monsters (1 or 2)? It's Pokémon mixed with Dragon Quest and it has tons of replayability If you like RPG's try to get Final Fantasy Tactics A2: it's a great game which is very lengthy too.Pre-Season Week 1 @ New York Giants: Last Call For Optimism On the last episode of the pod, Sam mentioned this being the hottest Dolphins blog on the internet. He quickly provided a disclaimer that the content didn’t reflect my personal appearance. To disprove his utter non-sense, I had some professional glamour shots done – enjoy. You aren’t born with biceps like those Now that games are on the horizon this blog will take on an altered format. My plan is still to produce two pieces per week but with very specific structure. Game PREVIEWS will include film study of the opponent, how we match-up with them and what to expect from the game. The game REVIEW will cover the aftermath using film-study, some advanced statistics and an overall feeling about the team’s standing. The title of this piece is fitting for Dolphins fans. This is the last opportunity to buy into homer-based theories on why this year will be different from the nearly two decades that precluded it. Now the team is putting hard physical evidence on tape of why we should or shouldn’t buy in. Now it’s time for my disclaimer. Whether the team plays great or gets annihilated, you shouldn’t change your preconceived notions about this team. Pre-season is coaches putting players in situations where they can see how well their talent shines through. These glorified scrimmages are hardly a glimpse of what is to be expected when the games count. The depth charts have been released and there are a few somewhat puzzling decisions. Adam Gase said himself, this one doesn’t matter. The one the team releases prior to the Seattle game will be the important depth chart. This is how you wind up with Dallas Thomas (who somehow got onto the field for 1,034 snaps last season) as a starting guard. The team put an emphasis on clean slates and Thomas’ high snap count a year ago is the only reason he gets that nod. These pre-season games are unique in the fact that they are, well, unique. Each game takes on a different alignment with the first game barring some similarities with baseball’s opening day. Coaches will make their best effort to get everyone some playing time. Most established vets won’t play a snap, the quarterback might get one series, and the fourth quarter will have 21 future grocery baggers and maybe one guy that sticks on the field at a given time. As you look at the match-ups, you have to consider the things that Miami wants to accomplish vs. what the Giants want to achieve. For the Dolphins there are a few obvious keys to watch for: – Sort out the guard situation – See if these rookie WR’s practice success can translate to game day – Find out just how dire this cornerback situation is – Play around with different sub packages on the front seven and see who wants playing time The Giants have a few of their own clear ideas in mind: – Who will start on the right side of the offensive line? – A good tailback will get cut from this team, but which one? – How does this young secondary play early on? Speaking of the Giants tailback situation, I would not have a problem with any of their top five finding their way to the Miami roster. They aren’t going to be able to keep Rashad Jennings, Shane Vereen, Andre Williams, Orleans Darkwa and Paul Perkins. The smart money is on Darkwa being cut, but in the event that he beats out Williams, I’ll take either/or over our third back as it stands. Specific things to keep an eye on. 1.) Sterling Shepard vs. Tony Lippett/Bobby McCain/Michael Thomas Bobby McCain is one of my favorite young players on this team. I have him entrenched in pen as the team’s nickel corner (who will play
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the tunnel, conscious and fueled by rage. Suddenly, the Doomslayer blasts Superman with the ship's informational engines. The blast from the ship's informational engines does not destroy Superman, instead it converts him into data and transfers him into the ship's informational engines, where he meets the ship's artificial intelligence. The AI reveals that the ship is actually a sentient creature from another universe that got injured during a journey. When it was healing itself, Luthor attacked it and modified it to suit his needs. When Supergirl threw the Doomsdayclone through the creature's tunnels, it was infused with the creature's knowledge, becoming the Doomslayer. Superman tells the creature that it canhelp, so the creature shows its internal schematics, teaching Superman how to repair it. When Superman learns everything he needs, the creature returns him to solid form. The Eradicator, meanwhile, defeats Superboy Doomsday in Moscow, and Zatanna teleports him to the ship and the heroes to Kansas, where they help Supergirl defeat Cyborg Doomsday. With the clones defeated, the heroes throw them way down into the pit the tower is located in, since the tower will also teleport things that are close to it. Reaching the tower's bridge, Superman manages to activate a sequence that will teleport the tower to its home before it reaches Earth's core. Suddenly, the Doomslayer attacks him but the Eradicator appears to help Superman. The Eradicator, telling Superman that it was an honor fighting alongside him, throws Superman out of the tower, seconds before it teleports away. With the battle over, Superman and Supergirl return to Metropolis. Later, Clark and Lois eat dinner in a restaurant. There, Clark admits to Lois about the Eradicator's sacrifice and that Luthor found out about his double life. He also says that maybe he should reveal his secret identity, but Lois says that it is not necessary, since the people will always trust Superman no matter what happens. Lois tells Clark that it was Jonathan and Martha Kent, not his coming from Krypton, that made him Superman. Clark and Lois then return home. Flashpoint In an effort to save his mother's life from the Reverse-Flash, Barry Allen unknowingly changes reality, creating a new world in which his friends's lives, Superman included, are drastically different. In this new world, Kal-El's rocket crashes directly in Metropolis, causing several deaths. The government takes custody of Kal-El and initiates Project Superman, a military project with the sole purpose of creating a supersoldier that could be used against America's enemies. Kal is designated as Subject One. In the cold and harsh environment of the project's labs, Kal grows to become a solitary and very thin boy who has difficulty getting close to people. Kal's only sources of love and companionship are General Sam Lane, who loves him as the son he never had, and Krypto, who is designated as Subject Two. Kal is then contacted by Subject Zero, the very first person inducted into Project Superman. Having obtained superpowers from the experiments, Zero talks to Kal in a volume only he can hear. Zero trains Kal in the use of his powers, including x-ray vision, as three years pass. Kal witnesses as Lionel Luthor and his son Lex visit the project labs. However, Zero unleashes Two on the Luthors, forcing the soldiers to kill him, much to Kal's grief. However, Kal manages to reach Zero's chamber and destroys the lock with his heat vision, unleashing Zero. As Zero wreaks havoc across the base, Kal returns to General Lane's office, where he meets Lois, General Lane's daughter. Kal and Lois, intrigued by each other, try to reach for the other's hands when Zero comes in. Zero tries to kill Lois as revenge for the experiments her father conducted on him, but Kal defends her. Zero, thanking Kal for letting him escape, tries to kill them both, but General Lane appears with a harness that seals them both in the Phantom Zone. Later, General Nathaniel Adam takes over Project Superman, imposing a more strict schedule on Kal. Returning to his cell, Kal uses his heat vision to draw a picture of Lois in the glass. Kal would reach maturity in his time in Project Superman. The Flash, Batman and Cyborg planned to free Kal from his cell so that he could join them in their mission to stop the war between the Amazons and the Atlanteans and return the timestream to normal. They manage to free Kal, exposing him to yellow sunlight. However, Kal, remembering Lois, flies away from the three heroes and goes to England. Also, Kal'srelease from the project labs had also destroyed the power source that kept Zero in the Phantom Zone, allowing Zero to break free. As Kal reaches England, he finds that Lois is being attacked by the Amazons. He quickly saves her and tells her that they must go somewhere safe from Subject Zero. Lois tells him she can't leave, as she must stay and end the war. Suddenly, Zero reaches England and attacks them. Kal and Zero fight with Lois standing in the middle. A group of Amazons try to intervene, but Zero kills them. Lois tells Kal that he must escape from Zero, but Kal refuses, remembering that General Lane told them that they must protect people from monsters like Zero. Kal continues the battle with Zero, noticing that the energy Zero absorbed from his dead opponents is causing his body to overload. Taking advantage of this, Kal punches Zero in the torso and destroys him in a massive explosion. Unfortunately, Lois is injured in the blast and Kal cradles her in his arms. Lois dies of her injuries, but not before telling Kal to save the people. Mourning her death, Kal decides to be a Superman. In the final battle of the Amazon-Atlantean war, Kal crushes the Enchantress, and then he fights Wonder Woman and Emperor Aquaman. However, the Flash manages to change reality again, creating a new world and allowing his friends to live their lives once again, but in a new way. DCnU In this new timeline, details of Superman's origins have changed and he is shown to have never married or developed a relationship with Lois Lane.[27][317] Superman begins a relationship with Wonder Woman. New Adventures After the Justice League's debut, Superman would have new enemies in his early years as a hero. Superman met the Legion of Super-Heroes and they travelled to Superman's past in order to save his younger self from the Anti-Superman Army.[319] This group of villains attempted to steal a piece of Kryptonite from Superman's rocket in order to kill Superman, but the heroes were able to stop them.[320] Superman would find himself pitted against Maxim Zarov, a hunter who had suspicions that Superman and Clark were the same person.[321] Also, Superman was forced to retire his Clark Kent identity and get a new identity as "Johnny Clark", a Metropolis firefighter.[322] During his time as Johnny Clark, Superman came across Captain Comet, a telepath who wanted to take Susie Thompkins, Lois' niece, with him, as she had telepathic powers as well.[322] With Susie's help, Superman is able to hold Captain Comet off. Also, with the help of Batman, Superman brings his Clark identity back from the dead. Clark has a conversation with Mrs. Nyxly, who reveals herself to be a fifth-dimension person called Nyxlygsptlnz. She tells him that a man from the fifth dimension, Vyndktvx is planning to ruin his life and Superman must stop him.[323] Superman is also able to release Krypto, the House of El's dog, from the Phantom Zone.[324] Later, Superman saves a Mars colonization program from an entity called the Multitude, but Vyndktvx kills the colonists.[325] Vyndktvx organizes the Anti-Superman Army to destroy Superman once and for all.[326] As Superman confronts the Anti-Superman Army, Lois and Jimmy join forces with the legion of Super-Heroes to get help from Mxyzptlk, Nyxlygsptlnz's husband.[327][328] With the help from his allies, Superman banishes Vyndktvx back to the fifth dimension. Nyxlygsptlnz thanks Superman for saving their worlds and Superman asks her to bring the Mars colonists back to life. As Mxyzptlk and Nyxlygsptlnz return to their dimension, Superman is free to live his life without interference.[329] Superman was then afflicted by some sort of infection, causing him to collapse.[330] Under the care of Dr. Shay Veritas, Superman begins to heal, but the infection separates itself from his body and becomes a creature of its own. With Dr. Veritas' help, Superman destroys the creature, but its virus spreads over to Metropolis, infecting several people.[331] Superman manages to cure the people, but he is then attacked by the virus' creator, Lex Luthor. After a lengthy fight, Superman defeats Luthor, who is arrested.[332] Superman also meets Kara Zor-El, his biological cousin and another surviving Kryptonian.[333] Their first meeting becomes a fight and Superman explains Krypton's fate to her.[334] Although Superman offers to help her, Kara decides to go
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in the entire Assyrian army with Venus and AC and it would be a 50/50 chance IMO. I will eat my legos and shit bricks if you guys can kill the Vindicator, hell if you guys can even scratch off half of its hit points) CHALLENGE ACCEPTED I'll take Secret Faction... 4? Remus: Harry... I'm a werewolf. Harry: Are you fucking serious? Remus: Well yes, but I don't see how that applies here. (You could throw in the entire Assyrian army with Venus and AC and it would be a 50/50 chance IMO. I will eat my legos and shit bricks if you guys can kill the Vindicator, hell if you guys can even scratch off half of its hit points) Just remember to always massively combine fire, use grinding rules, aim for weaker spots (like weapons) first, and not stand too close together.Q: Is it bad practice to add a flag to throw an exception? I have some methods in a class that I think could be useful for testing stuff, but also in some cases the program may want to halt completely if the check fails. Originally I was wrapping the method calls in if conditions and then throwing an exception, however, I ended up having the same if conditions in many methods and it seemed wasteful, so I added a boolean flag to the check method to have it throw an exception if the check failed. An example: public function isValidDirection($direction, $throwException = false) { if(!in_array($direction, $this->getDirections()) && $throwException) { throw new \InvalidArgumentException(sprintf('Invalid direction value. Valid directions are: "%s"', implode(", ", $this->getDirections()))); } return in_array($direction, $this->getDirections()); } Is this a bad idea? I've not come across this kind of pattern before and I'm wondering are there any pitfalls to it? A: An exception should be thrown in exceptional circumstances. That means when your code is in a situation that it is not prepared to handle. If your function is a validation function whose job it is to confirm the validity of data, there should hardly be any exceptional error possible. The job of the function is simple: take input, return true or false depending on whether it's valid. If you want to handle the case of invalid input by throwing an exception and you want to DRY that repetitive check, create another function which wraps your validation function. So you'd have two functions: isValidDirection($input) and assertIsValidDirection($input), the latter of which throws an exception if it's not valid and otherwise does nothing. function isValidDirection($input) { return ...; // true or false } function assertIsValidDirection($input) { if (!isValidDirection($input)) { throw new InvalidArgumentException; } } This keeps both functions' responsibilities clear and their implementation simple. Spain’s Bad Bank Needs Goodwill From Europe’s Leaders Nov. 26 (Bloomberg) -- Spain is trying hard to shore up its banking system, an endeavor crucial to the recovery of the euro area’s fourth-largest economy. To improve the chances for success, Europe’s leaders need to send a clear signal that the costs to Spain’s government won’t get out of control. On Dec. 1, Spain plans to put in place a central element of its financial-sector rescue agreement with the European Union: a “bad bank” designed to unburden the country’s commercial lenders of some of their worst assets. The bank will spend as much as 90 billion euros ($115 billion) to buy foreclosed properties and soured real-estate loans, at prices ranging from about 20 percent to 68 percent of face value. To mitigate the cost to the government, it hopes to raise several billion dollars in capital from private investors. The move is more significant as an indicator of Spain’s political will than as a salve for a troubled banking system. It addresses only a small fraction of the 1.5 trillion euros in assets that the government’s consultant, Oliver Wyman, has identified as potentially problematic. At best, it will speed up the process of recognizing losses at banks without much changing the amount of capital they must raise to offset the losses. Capital Needs Even with the bad bank, Spain’s financial institutions will need a lot of capital. Oliver Wyman’s adverse scenario projects capital needs of about 60 billion euros, assuming losses of only 4.1 percent on some 600 billion euros in retail mortgage loans. If a contracting economy and rising joblessness lead mortgage borrowers to default in greater numbers, the amount of money needed to keep Spain’s banking system afloat could be much larger. The big question, then, is how much of the cost will fall on the already-strained budget of Spain’s government. In principle, Spain can afford to spend 60 billion euros to prop up its banks, or even the full 100 billion euros other governments have offered to lend it for the purpose. The added borrowing would increase the country’s debt burden by as much as nine percentage points of gross domestic product, only marginally affecting the longer-term challenge of getting its finances under control. What’s more, Spain would use the money to purchase bank equity, which it might eventually sell at a profit. The greater danger, for markets and for Spain’s solvency, is that the government’s bailout costs might spiral out of control as recession, banking paralysis and defaults reinforce one another. As long as that risk remains, Spain will have a hard time attracting investments and getting its economy growing again. Here’s where Europe’s leaders come in. They’ve pledged to form a banking union in which governments would take collective responsibility for overseeing banks and for recapitalizing (or liquidating) them if they fail. They’ve stopped short, however, of defining the point at which the new system would kick in. Germany has suggested that “legacy” assets, such as Spanish banks’ toxic real-estate loans, would be the sole responsibility of national governments. This leaves the biggest issue for Spain unresolved: What will happen if performing loans -- many of them fueled by the past easy-lending practices of banks in Germany and other euro-area countries -- turn sour in the future? To restore confidence, the governments of the euro area should set a reasonable limit -- say, 100 billion euros -- to Spain’s responsibility for salvaging its banks. They should also make sure the banking union is up and running in time to handle any further capital needs. Slipping beyond the Jan. 1 target date will only aggravate Europe’s financial and economic ills. A currency union consisting of such varied economies as Europe’s cannot survive unless its members share risks. The predicament of Spain’s banking sector offers a test of European leaders’ ability and willingness to do so. If it turns out that they can’t or won’t, one wonders what they were thinking when they created a joint currency in the first place. Today’s highlights: Today’s highlights: the editors on why the U.S. should allow natural gas exports; William D. Cohan on Jon Corzine’s tenure at MF Global; Simon Johnson on whether the New York Fed president will try to stop sensible bank reform; David Kornblau on regulating markets like the nuclear power industry.Rennsport Reunion IV The world's greatest gathering of historic and contemporary Porsche race cars (and their drivers) takes place October 14-15 at Mazda Raceway Laguna Seca. This Rennsport Reunion IV will highlight the decades-long success story of the Porsche 911 race cars. To showcase that, artist Dennis Simon has painted the official poster, which features a 1981 factory 935 long tail in Martini colors and Al Holbert's 911 RSR from 1974. Simon, for the record, has created posters for two of the previous Rennsport events, and both are said to be collector's items. A Part of Hearst Digital Media Road & Track participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites.City in Lebanon with 30,000 inhabitants (2003 estimate), in the Janub governorate, in the south of the country and on the coast facing the Mediterranean Sea.Tyre was originally built on an island right off the coast, providing for natural defence. Many functions were established on the mainland as well, but all important institutions remained on the island. But from 332 BCE and on, a causeway was connected the island to the mainland, making it a peninsula.Tyre was for centuries the strongest and most important Phoenician city, exercising control over the others from 10th century BCE and onwards. The city was famous for its silk products, and its purple dye extracted from the Murex snail.The old harbour area has been excavated, but most of the Phoenician city lies under the modern city. HistoryAround 2000 BCE: Tyre is founded on a