envedabio/plant-phenotype · Datasets at Hugging Face

text stringlengths 0 808
10819439 93 96 HIV Negative_phenotype

10819439_8 However, only PS extract suppressed HIV production at the same concentration when the drugs were added during HIV adsorption.
10819439 14 16 PS Plant
10819439 36 39 HIV Negative_phenotype
10819439 110 113 HIV Negative_phenotype

10819439_9 Presumably, the penetration of the PS extract into the cells was required for this activity.
10819439 35 37 PS Plant

10819439_10 Secondly, fractionated PS inhibited HIV reverse transcription in a non-competitive manner.
10819439 23 25 PS Plant
10819439 36 39 HIV Negative_phenotype

10819439_11 This fractionated PS kept anti-HIV activity, but inhibited HIV replication and adsorption to a lesser extent compared to dextran sulphate.
10819439 18 20 PS Plant
10819439 26 34 anti-HIV Positive_phenotype
10819439 59 62 HIV Negative_phenotype

10819439_12 Lastly, an active component(s) was detected in plasma in vivo, after injection into the intestine, which demonstrates the feasibility of oral administration dosing.

10841870_1 Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi) BACKGROUND: Chinese-herb nephropathy is a progressive form of renal fibrosis that develops in some patients who take weight-reducing pills containing Chinese herbs.
10841870 0 20 Urothelial carcinoma Negative_phenotype
10841870 64 84 Aristolochia fangchi Plant
10841870 98 122 Chinese-herb nephropathy Negative_phenotype
10841870 148 162 renal fibrosis Negative_phenotype

10841870_2 Because of a manufacturing error, one of the herbs in these pills (Stephania tetrandra) was inadvertently replaced by Aristolochia fangchi, which is nephrotoxic and carcinogenic.
10841870 67 86 Stephania tetrandra Plant
10841870 118 138 Aristolochia fangchi Plant
10841870 149 160 nephrotoxic Negative_phenotype
10841870 165 177 carcinogenic Negative_phenotype
10841870 Increase 118 138 Aristolochia fangchi Plant 149 160 nephrotoxic Negative_phenotype
10841870 Increase 118 138 Aristolochia fangchi Plant 165 177 carcinogenic Negative_phenotype

10841870_3 METHODS: The diagnosis of a neoplastic lesion in the native urinary tract of a renal-transplant recipient who had Chinese-herb nephropathy prompted us to propose regular cystoscopic examinations and the prophylactic removal of the native kidneys and ureters in all our patients with end-stage Chinese-herb nephropathy who were being treated with either transplantation or dialysis.
10841870 28 45 neoplastic lesion Negative_phenotype
10841870 114 138 Chinese-herb nephropathy Negative_phenotype
10841870 293 317 Chinese-herb nephropathy Negative_phenotype

10841870_4 Surgical specimens were examined histologically and analyzed for the presence of DNA adducts formed by aristolochic acid.

10841870_5 All prescriptions written for Chinese-herb weight-reducing compounds during the period of exposure (1990 to 1992) in these patients were obtained, and the cumulative doses were calculated.

10841870_6 RESULTS: Among 39 patients who agreed to undergo prophylactic surgery, there were 18 cases of urothelial carcinoma (prevalence, 46 percent; 95 percent confidence interval, 29 to 62 percent): 17 cases of carcinoma of the ureter, renal pelvis, or both and 1 papillary bladder tumor.
10841870 94 114 urothelial carcinoma Negative_phenotype
10841870 203 226 carcinoma of the ureter Negative_phenotype
10841870 228 240 renal pelvis Negative_phenotype
10841870 256 279 papillary bladder tumor Negative_phenotype

10841870_7 Nineteen of the remaining patients had mild-to-moderate urothelial dysplasia, and two had normal urothelium.
10841870 39 76 mild-to-moderate urothelial dysplasia Negative_phenotype

10841870_8 All tissue samples analyzed contained aristolochic acid-related DNA adducts.

10841870_9 The cumulative dose of aristolochia was a significant risk factor for urothelial carcinoma, with total doses of more than 200 g associated with a higher risk of urothelial carcinoma.
10841870 23 35 aristolochia Plant
10841870 70 90 urothelial carcinoma Negative_phenotype
10841870 161 181 urothelial carcinoma Negative_phenotype
10841870 Increase 23 35 aristolochia Plant 70 90 urothelial carcinoma Negative_phenotype
10841870 Increase 23 35 aristolochia Plant 161 181 urothelial carcinoma Negative_phenotype

10841870_10 CONCLUSIONS: The prevalence of urothelial carcinoma among patients with end-stage Chinese-herb nephropathy (caused by aristolochia species) is a high.
10841870 31 51 urothelial carcinoma Negative_phenotype
10841870 82 106 Chinese-herb nephropathy Negative_phenotype
10841870 118 130 aristolochia Plant
10841870 Increase 31 51 urothelial carcinoma Negative_phenotype 118 130 aristolochia Plant
10841870 Increase 82 106 Chinese-herb nephropathy Negative_phenotype 118 130 aristolochia Plant

10884715_1 Increased waist size and weight in relation to consumption of Areca catechu (betel-nut); a risk factor for increased glycaemia in Asians in east London.
10884715 10 20 waist size Neutral_phenotype
10884715 25 31 weight Neutral_phenotype
10884715 62 75 Areca catechu Plant
10884715 77 86 betel-nut Plant
10884715 117 126 glycaemia Negative_phenotype
10884715 Increase 10 20 waist size Neutral_phenotype 62 75 Areca catechu Plant
10884715 Increase 25 31 weight Neutral_phenotype 62 75 Areca catechu Plant
10884715 Increase 62 75 Areca catechu Plant 117 126 glycaemia Negative_phenotype
10884715 Increase 77 86 betel-nut Plant 117 126 glycaemia Negative_phenotype

10884715_2 Type 2 diabetes is commoner in Asians than Caucasians.
10884715 0 15 Type 2 diabetes Negative_phenotype

10884715_3 Many nitrosamines are diabetogenic, causing both type 2 and type 1 diabetes.
10884715 22 34 diabetogenic Negative_phenotype
10884715 49 75 type 2 and type 1 diabetes Negative_phenotype

10884715_4 Of CD1 mice fed with betel-nut or associated nitrosamines 8.5% develop glucose intolerance with marked obesity.
10884715 21 30 betel-nut Plant
10884715 71 90 glucose intolerance Negative_phenotype
10884715 103 110 obesity Negative_phenotype
10884715 Association 21 30 betel-nut Plant 71 90 glucose intolerance Negative_phenotype
10884715 Association 21 30 betel-nut Plant 103 110 obesity Negative_phenotype

10884715_5 Glycaemia and anthropometric risk markers for type 2 diabetes were therefore examined in relation to betel usage in 993 'healthy' Bangladeshis by one bilingual research-worker (N.M.).
10884715 0 9 Glycaemia Negative_phenotype
10884715 46 61 type 2 diabetes Negative_phenotype
10884715 101 106 betel Plant

10884715_6 Of these, 12% had known diabetes.

10819439 93 96 HIV Negative_phenotype

10819439_8 However, only PS extract suppressed HIV production at the same concentration when the drugs were added during HIV adsorption.

10819439 14 16 PS Plant

10819439 36 39 HIV Negative_phenotype

10819439 110 113 HIV Negative_phenotype

10819439_9 Presumably, the penetration of the PS extract into the cells was required for this activity.

10819439 35 37 PS Plant

10819439_10 Secondly, fractionated PS inhibited HIV reverse transcription in a non-competitive manner.

10819439 23 25 PS Plant

10819439 36 39 HIV Negative_phenotype

10819439_11 This fractionated PS kept anti-HIV activity, but inhibited HIV replication and adsorption to a lesser extent compared to dextran sulphate.

10819439 18 20 PS Plant

10819439 26 34 anti-HIV Positive_phenotype

10819439 59 62 HIV Negative_phenotype

10819439_12 Lastly, an active component(s) was detected in plasma in vivo, after injection into the intestine, which demonstrates the feasibility of oral administration dosing.

10841870_1 Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi) BACKGROUND: Chinese-herb nephropathy is a progressive form of renal fibrosis that develops in some patients who take weight-reducing pills containing Chinese herbs.

10841870 0 20 Urothelial carcinoma Negative_phenotype

10841870 64 84 Aristolochia fangchi Plant

10841870 98 122 Chinese-herb nephropathy Negative_phenotype

10841870 148 162 renal fibrosis Negative_phenotype

10841870_2 Because of a manufacturing error, one of the herbs in these pills (Stephania tetrandra) was inadvertently replaced by Aristolochia fangchi, which is nephrotoxic and carcinogenic.

10841870 67 86 Stephania tetrandra Plant

10841870 118 138 Aristolochia fangchi Plant

10841870 149 160 nephrotoxic Negative_phenotype

10841870 165 177 carcinogenic Negative_phenotype

10841870 Increase 118 138 Aristolochia fangchi Plant 149 160 nephrotoxic Negative_phenotype

10841870 Increase 118 138 Aristolochia fangchi Plant 165 177 carcinogenic Negative_phenotype

10841870_3 METHODS: The diagnosis of a neoplastic lesion in the native urinary tract of a renal-transplant recipient who had Chinese-herb nephropathy prompted us to propose regular cystoscopic examinations and the prophylactic removal of the native kidneys and ureters in all our patients with end-stage Chinese-herb nephropathy who were being treated with either transplantation or dialysis.

10841870 28 45 neoplastic lesion Negative_phenotype

10841870 114 138 Chinese-herb nephropathy Negative_phenotype

10841870 293 317 Chinese-herb nephropathy Negative_phenotype

10841870_4 Surgical specimens were examined histologically and analyzed for the presence of DNA adducts formed by aristolochic acid.

10841870_5 All prescriptions written for Chinese-herb weight-reducing compounds during the period of exposure (1990 to 1992) in these patients were obtained, and the cumulative doses were calculated.

10841870_6 RESULTS: Among 39 patients who agreed to undergo prophylactic surgery, there were 18 cases of urothelial carcinoma (prevalence, 46 percent; 95 percent confidence interval, 29 to 62 percent): 17 cases of carcinoma of the ureter, renal pelvis, or both and 1 papillary bladder tumor.

10841870 94 114 urothelial carcinoma Negative_phenotype

10841870 203 226 carcinoma of the ureter Negative_phenotype

10841870 228 240 renal pelvis Negative_phenotype

10841870 256 279 papillary bladder tumor Negative_phenotype

10841870_7 Nineteen of the remaining patients had mild-to-moderate urothelial dysplasia, and two had normal urothelium.

10841870 39 76 mild-to-moderate urothelial dysplasia Negative_phenotype

10841870_8 All tissue samples analyzed contained aristolochic acid-related DNA adducts.

10841870_9 The cumulative dose of aristolochia was a significant risk factor for urothelial carcinoma, with total doses of more than 200 g associated with a higher risk of urothelial carcinoma.

10841870 23 35 aristolochia Plant

10841870 70 90 urothelial carcinoma Negative_phenotype

10841870 161 181 urothelial carcinoma Negative_phenotype

10841870 Increase 23 35 aristolochia Plant 70 90 urothelial carcinoma Negative_phenotype

10841870 Increase 23 35 aristolochia Plant 161 181 urothelial carcinoma Negative_phenotype

10841870_10 CONCLUSIONS: The prevalence of urothelial carcinoma among patients with end-stage Chinese-herb nephropathy (caused by aristolochia species) is a high.

10841870 31 51 urothelial carcinoma Negative_phenotype

10841870 82 106 Chinese-herb nephropathy Negative_phenotype

10841870 118 130 aristolochia Plant

10841870 Increase 31 51 urothelial carcinoma Negative_phenotype 118 130 aristolochia Plant

10841870 Increase 82 106 Chinese-herb nephropathy Negative_phenotype 118 130 aristolochia Plant

10884715_1 Increased waist size and weight in relation to consumption of Areca catechu (betel-nut); a risk factor for increased glycaemia in Asians in east London.

10884715 10 20 waist size Neutral_phenotype

10884715 25 31 weight Neutral_phenotype

10884715 62 75 Areca catechu Plant

10884715 77 86 betel-nut Plant

10884715 117 126 glycaemia Negative_phenotype

10884715 Increase 10 20 waist size Neutral_phenotype 62 75 Areca catechu Plant

10884715 Increase 25 31 weight Neutral_phenotype 62 75 Areca catechu Plant

10884715 Increase 62 75 Areca catechu Plant 117 126 glycaemia Negative_phenotype

10884715 Increase 77 86 betel-nut Plant 117 126 glycaemia Negative_phenotype

10884715_2 Type 2 diabetes is commoner in Asians than Caucasians.

10884715 0 15 Type 2 diabetes Negative_phenotype

10884715_3 Many nitrosamines are diabetogenic, causing both type 2 and type 1 diabetes.

10884715 22 34 diabetogenic Negative_phenotype

10884715 49 75 type 2 and type 1 diabetes Negative_phenotype

10884715_4 Of CD1 mice fed with betel-nut or associated nitrosamines 8.5% develop glucose intolerance with marked obesity.

10884715 21 30 betel-nut Plant

10884715 71 90 glucose intolerance Negative_phenotype

10884715 103 110 obesity Negative_phenotype

10884715 Association 21 30 betel-nut Plant 71 90 glucose intolerance Negative_phenotype

10884715 Association 21 30 betel-nut Plant 103 110 obesity Negative_phenotype

10884715_5 Glycaemia and anthropometric risk markers for type 2 diabetes were therefore examined in relation to betel usage in 993 'healthy' Bangladeshis by one bilingual research-worker (N.M.).

10884715 0 9 Glycaemia Negative_phenotype

10884715 46 61 type 2 diabetes Negative_phenotype

10884715 101 106 betel Plant

10884715_6 Of these, 12% had known diabetes.