Datasets:

dotan1111

/

MSA-amino-10-seq

like 0

CCCCTCTCTC---W---S---------K---------A---------C---------I---------R-----T---T-----C---C-----E---E-----S---S-----R---R-----F---F-----Y---Y-----V---V-----R---R-----T---T-----I---I-----P---P-----G---G-----E---E-----V---V-----F---F-----F---I--LLLLLLLLLLPQQQRRRQRQYYYYYYYYYYNHNNNNNNNNKKKKKKKKKWIFLLIIILLIDDDDEDDDDDAAAATATASAKKKKKKKKKKDGDDDDDDDDQEEEEEEEEERHHHVAAHAHIIATAAAAAAAAAAAAAAAALLLLILLLLLSSSDSSRDSSNTNNSNSNNTRRRRRRERRREEEEEEEEEEKKRRKKRRKKLLLMLLLMLLVVVVTVTITVKEEEEEEEEEDDDD---D-DGGGG---G-GNNNN---N-DS---------L---------Y---------H---------P---------I---------I---------K---------S---------P---------K---------R---------T---------G---------G---------L---------N---------H---------D---------V---------D---------T---------K---------P---------E---------E---------D---------V---------P---------D---------T---------E---------V---------K---------N---------E---------E---------I---------K---------R---------R---------L---------HHHH---H-HLLLL---L-LLLLL---L-LDGGG---G-GVVIV---V-IIVIV---V-LRRRR---R-RLL-------LFFFF---F-FQTTT---T-TEEEE---E-EILLL---L-LVVVV---V-VLILL---L-LQQHH---Q-HQQQQ---Q-Q-------S--KKKK---K-KQQQH---H-QSSSSSSSSSSDDDDSNADADTTSTTTTTTTMMMVLLLQLMLLLLLLLLLIKKKKRERKRKGGDGGGGDGGVVVVVIVVIVAAVAAAAAAAGGGGGGKGGGQQQRQRQRQQLPLLLLLLLL

LLLLLLLMLLAGAGAGGAGATSTTTTSTTTFFFFFIFFLF---R---------T---------Y---------W---------H---------T---------L---------L---------G---------H---------E---------V---------S---------F---------L---------I---------V---------V---------N---------S---------K---------F---------D---------L---------I---------K---------K---------D---------S---------F---------N---------L---------K---------F---------G---------S---------G---------E---------V---------L---------Q---------L------NNNNNNNGTSIIIIIVIVIIEEEEEEEEEELIIIIIIIIICCCCCSCDCCTTTKTTTTTTNEKENEEAENCCCCCCCCCCIEIIIIEITIGGGGGGGGGGLLLLLLLLLLTTTTTTTTTTMLLFMFLFLMDDDDDDDDTDLLRLLLLLLLVDVVVVAVAVGRGRGRRGRGIIIIIIIIIIFVSVFVVVVFG-MGGG-GGGV-VVAV-VVVNGSGSGGGGSTPTATAQAQTLLLTLMLMLLVVVVVVVVVVKKKKKKKKKKYFYFYFFFFYSATSTTATATTSSSASSSSASSSSSSSSSSATSRSTTRTSA-ETSTTTLS---------Y---------G---------A---------Q---------P---------L---------R---------R---------F---------T---------I---------H---------L---------R---------T---------K---------G---------K

KKKKKKKKKKKKFKFKKKKKLLL-L-----KDDDDDDDDDHHHHHHHHHNSSTSTTSSSTLLLLLLLLLL--------V-KKEKENKKKKSSNNSGNNNNELLLLLLILLLLLLLLLLLLRRRRRRRRRRAANCNIVAVVYYYYYFYYYYDDDDDDDDDDAAAASAAAAADDDDDDDDDDAAGAGAVAAARRRRRRKRKKPPPPPPPPPPAAA-I-----EEE-E-----RRRRRKQRRQQQQLQLFLLLLLLMLIMMMMTTTTTTTTTTGGAGSGGGGGAAAAAAAAAAVVVVVVVVVVLFFFFFFFFFPPPPPPPPPPAAAAAAAAAAKRTQKQQQQQGGGGGGGGGGVVVVVVVVVVDDDDDD-D-DMMMMMM-M-MGGGAGG-A-GEEEEEE-E-EDDDDDD-D-D

GGGGGGGGGGGGGGCGGGGGSNNNNNNNNNKKDKKKKKKKLLLLLLLVLLQILFLLQLLLMIMLAMMCIVCICCICCVIITTTTTNTTNTPPPPPPPPPPKKKKKKKKKKRRRRRRRRRRKEEEEEKEEEFYYYYYFYYFETDDTDDTTTASAASAAASALLLFLLLLLLLSLLSLLLSMPPPPPPPPPPDANDSNDSASDDDDDDDDDDPLPPLPPLLLTRTTRTTTRTAAAAAAAAAAEEEEEEEEEEDSSSSTSSTSAVVVVVVVV-TIATTTTTT-KKKKKKKKKKGGGGGGGGPGVIIVIIVIIIPAPPAPPAAAQQQQQEEQQQNKRKKRNRKRSSSSASSSSSVIIINIIIIIDDDEDDDDDDLILLVLLAIAYIVIIIIIIIDNDDNDNNND

RSRSRRRRKSIIIVIIIIIVLLLLLLLLLLLLILIFLLILRRRRRRRRRRPPPPPPPPPPV-VVTVVVVVE-EEEEEDEELLLLLLLLVLTTTTATTTRTCCCCCCCCCCDDDDDDDDDDLLLVLLLLLV--A---------Y---------L---------R---------Q---------G---------C---------P---------F---------T---------S---------V---------E---------L---------A---------M---------F---------D-------PL-LPPPPSLEE-ESEEESEVV-VVVIVVVVL-KVVVVTIFYFYFWFWFYETSMSSSSSTVVVTVVVVVVIIIIIIIVIILLLLLLLLLLLL-L-LLM-L------D---DDDDEDDDEDKKKKKKKRKRLLLLLLLLLLGAGAGAAAGAENEPEEEEEPKRARRRRRRRGGGGGGGGGGSDSSSSSSQSRKHKHRRNHKLLLLFLLLLQLLLLLLLLLLVVVVVVVVIVSASESASSSA

EDDDEKEEEEPAPPPPPPPPRTKKKKKRKKLIIILVVLLLLLLLMLLLLMEPPPPPPIPPNNNNDNNNNNLLLLLLLLLLEEEEEEEEEEMFMFFFFFFFRRARRRARRRKKKKKKKKKKLLLLLLLLL-I------I--YYYYYHYYY-EEEEEEAEE-VVVVVVVVV-TTTTTTSTT-AAAAAAAAA-QQQQQLQQQ-PTPTPPPPP-KKREKKRKK-IIVIVVVVV-DDDDDDDDD-IIIIITIII-EKKKEEKEE-RRRRRRRRR-EEEEEEEEE--AAA--A---SSSSSSDSS-L----L-IL-VVVVVVVVV-TSSSSTSTT-IIIIIVIII-LLFLLLLLLFRRRRRKRQRRAAAAAAAAAAPPPDPPPPPPMFFFFFFMFFAAAAATAAAAQKQQQQNQQQEEEEEEEEEE

GPSGGGSGGGGGGGGGGGGGFHEHHHEHHHKKRKKKRRKRAAAAAAAAAQKKKKKKKKKKAAVAAAVCKARKKRRKKTRTCCCCCCCICIH---------EEEE-EEEEEPPPP-PPPPPDDDD-DDEDDGGGG-GGGGGGGGG-GGGGGGGGG-GGNGNIITI-ITLILPPPP-PPPPPRRRR-RKKRR-FL--FLF-F-SS--STS-S-TS--TGS-S-LL--LLF-F-LF--LLL-L-TT--MT----HH--HH----AL--ALL-L-YY--YYY-Y-FF--FFF-F---------P-HH--HHH-H-LM--LLL-L-VC--VCV-V-TT--TTV-V-LL--LLL-L-VS--GSA-A-VL--VLL-L-GG--GGG-G-DE--EEE-ERRRR-RRPRRYFYY-FFYYHAEEE-EEEEE

SSSSCSSSSSRRRRKRRRRRVVAVVVVVVVIIIIIIIIIIIIMIMIIIFCVVLVVVVVTLLLLLLLLLLLNNNNNNNNNNAAASASASASAKKKKKAKAKVVVVVVVVVVEEEEEDEEEDNRRRRRNRRRPPPPPPPPPPHHNHHQHHHQAAASASASASLLLLLLLLLLYYYYYYYYYYMMMLMMMMMTKKKKKKKKKKNNNNNNNNNNRNLSLNNNNNQRRRRRQRRRDNNNNNNNNNKKKKKKKKKKGGGGEGGGGGRHRRRRRRRRVRRSRSVSRSYYYYYYYYYYLLLLLLLLLLESSSMSETESPPPPPAPPPASSSSSSSSSSVVVVVVVVIVKKKKKKKKKKFFFFSFFFFF

TTTTTTTTTTLLLLLLLLLLLVVVVVVVVLDDDDDDDDDDGGGGGGGGGG-T---------P---------K---------E---------E---------K---------S---------R---------D---------E------------F--F--AGAAAAAAAAGGGGGGGNGGPPPPPPPPPPAVVSAVVASARRKRRRRRRRMLLLLLLLLLQQQQQQQTQQ-DD--DD---WYYWWYYYWWVANAANAAPALLLLLLLLLLYYYYYYFYYYYYYYYYYYYYGTGGGGGGGGDSDADDSDADAAAAAAAAAAYKKVYKKYHYRKKRRKKRRRYYYYYYYYYYFFFFFFFFFFEEEEAEEAEEMMMMMMMMYMEEEEQEEEEEFCCCCCCCCFSLISPIIPSSYYYYYYQYYYPPPPPPPPPPRRRRRRRQRWNNNNNNNSNNIIIIVIIIIITSTTTTTTQTSQQSPQQPSSIIIIIIIIIIMMMMMMMMAMEKKEEKKEEKGGSGASGGGGKKKKKKKKKKVVVVVVVVVP

VVYFVFVFVVYVYYYYIYYYRRERRRRRRRGNNDGNGDGGMMKKMMMKMMGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGQQQQQQQQQQAKSPAAYSAATTTTTTTTTTAAAAAAAAATKRAAKKKA-KIIIIIIII-ISSKKSSSKSSGGGGGGGGGGEEEEEEEEEEMMMMMMMMMMTSLLAATLSARNNNNNNNNNLL-LLLLLLLAA-AAAAAAANN-NNNNNNNKK-NKKKNKKRR-KRKRKRRII-IIIIIIIKK-KKKKKKKKP-PPPPPPPFF-YFFFFFF---TTT-TTTVV-VVAVAVAFF-FFFFFFFII-IIIIIIIRR-RRRRRRRVF-MIIFMVIYD-EDDDEKDLL-VLLLCFLSS-QSSSQSSIV-IIIIVIIVVVVVVVIAV

EEEEEEEEEEIIVVVVIVIID-----T-D-QHHHHYHHHHEDEEEEEEEEAAKKAAARAPAHHHHHHHHHMMMMLLMMMMVVVVVVVVIVRRRRRRRRRRVIVVVIVVVVVVVVIVVVVVWWWWWWFWFTPPPPPPPPPPCCCCCCCCCCEEQQEEEEEEILIILLILILNNSGSSNNNNIVIIVVLIIVEEEEEKEEEKPPPPSPPPPPKKKKKKKKKKLLLLLLLILLMMMMRMNMMMVVLLVTVLVISSSSSSSSSSAAGTAAATAASTTTTTSTSTTIHNII-N-IHNHHDDHHHHAACAAAAVAAHHHHYFHHHHASHHKKARASKKKKKKKNKKQQQQQQQQQQ-----A---------D---------E---------L---------D---------L---------A---------G---------R---------S---------P---------V---------P---------E---------L---------H---------T---------L---------P---------L----CCCCECFCCYAAAAAAAAAA

-SS----S---GG----G---GG----G--AGG-ASSGA-GRG-GGGGG-NNN-NDNNN-H-G-HGGGH-DDD-DDDDE-SVC-SACCS-YVI-YFFIY-SAS-SSSTS-KKA-KKKAK-EEE-EKKEE-TSTSTTTTTS---P-----PDDDDDDDDDDNDDDDDDDDDKKKKKKKKKKDDDDDDDDDDCCCCCCCCCCYYYYYKYYYY-H---------V---------P---------I--------LLLLLLLLLLNEEHNQQENER---R---R-R---R---R-----L---------I---------N-----AAAAAKKAAAFWYWWWWWFWGGGGGGGGGGYFFLFFFFMFSTSTSSSSSTIWWWWWWWFWCCFACCCCCAPSSSSSSSSSIMIMIIIIIMRRRRRRRRRRDDDGDDDDDGI-F-VVVLI-P-P-PPPPP-F-F-FFFFF-V-Q-VVIVV-GGGGGGGGGGVLLLVLLLVLFLLLLLLLFLAAAAAAAAAA

TTTTTTTTTTAKAAAAAAQAIAVIIIVVIINQKQQQQQQQFLFFFFFFFLYLYYYYYFFYIVIVIVVIVVNRNKKKKRRKLLLLLLLLLL-----G---------L---------P----PPPPPPPPPPQQQRQEQQQEL-L-LI---LW-W-WR---RM-M-ML---MY-Y-HD---DV-V-VM---MSASSSSSASAAPAAAATPPAKKKKKKKKKKAAAASSAAASMLMMMMMMMMGEGGGGGGGGNQNSNNSQQNHPHSHHHPPHQQQQQRQQQQL-LLLNLLLNLLLHLLHLLLRKRKKRKKKRRRRRKRRRRRFFFFFMFFFMK-KKKKRKKKV-VVVVVGVVA-ATAATAAF

LLLLLLLIILKRKRKKRRKRTTTTTTTTTTMMMMMCMFMMMMIMMIMMIMCCCCCCCCCCILLILLLLLLKEKEKKEEKEATTTTTTTTNGGGGSGGGGGERAKEEKKEKNTTTTTTTTTMLLLLLLLLLPKPTPPSSPSRRRKRRRRRRPPPPPPPPPPKQKKKNNKKNAAAAAAAAAAFF-FF-FF-FDD-DD-NN-NGE-EG-EE-ERR-RR-RR-RES-SE-SS-SKKTKKSKKKKSSSSSSSSSSPPPPPPPPPPVIVVVVVVVVTVVVTVVVVVEEEEEEEEEEVAVAVVVVVVLLLLLLLLLLLLLLLLLLLL------C---------I---------P---------P---------D---DDDDNDDDED

SSTNSSTSTTAAAAAAAAAA--L---L-LLLLLLLLLLLLAAAAAAAAAAKREKKKEKEEA---A-----QHHHQH-HHHRSSSRS-SSSIIVIIIFIFFDEEDEEEEEE-AAAAAAAAA-IIIIIIIVQ-IVIILVIVINNNHNKNNNNYEYYYYYYYYWWLWWWWWWWRRRRRRRRRNKKKKKKKKKKQRQQQQQRQKMMMMMIMMVMPPPPPPDPPPLMLMLLLMLLDDDEDDDDDD--------P---------K-GAASGSAAAADACADAAAAAVVIVVIVVMIF-LLFKLFLLI-QMIMLMMMTTSSTSSTSSNNNNNNNNNNAARRARRARREEENEVEEEELFIILVIFMLHHTHHNSHSSSSSSSASASSCCCCCCCCCCIIVLIIVIVV

PPPPPPPPPPTTTTQTQQQTPPPPPPPPPPGGGGGGGGGGHHYHRHHHHH-E---EEDDEITVTIVIVVTEEEEEEEEEEGNGGNNNNNNPNPPPNPPPNPPPPPPPPPPDSDDDDDDDSGGGGEGGGGGYFFYFFFFFFVIVVVIVVVVRRRRRRRRRRVVIVFIFFYVASAASSSSSSQQQQQQQQQQQGQQQEQEENYYYYYYYYYYVVVVVAVVVVVVVVIVVVVIGSSGPISSSSSSENDDDADDDIHHRARSSHQVQQLVVIVVDEEEEEEEEEKKKKKNKKKKKAKKKKKAKAFFFFFFFFFFAAAATATTTASASSAAASSAHNNNNNNNNNLLVLLLLLLLEEDEEEEEEE

NNNGNNNNNNKKKKKKKKKKHTTTTTTTTTAGGGGGGGGGGVAAGGGAAAAAAAAAAAAAPPPPPPPPPKGGGGGGGGGGIIIIIIIIIIFFYHFFFFFLRRRRRRRRRRSSGSSSSSSSPPPPPPPPPPEEQEEEEEEQSSSSSSSSSSEEEEEEEEEEVVVVVMVVMVVVVVVVVVVVKQQRQTQQQSLILFLLLLLLRRKKRRRRKKIIIIIIIVIIAEEEAAAEEELLLILLLLLMLLLLLLLLLLLILLLLLLLLRRRRRRRRRRVVVVVVVVKVKKSSAAKKSSLVLLLLLLLQCCCCTTCCCCEQEQEEEEQGLLLLLLLLLLTTTTTTTSTTLLLLLLLLLLKRKKRRKKKKEEEAEKEEEE

RRRRRRRRRRLTTATLTTTLLLALLLLSLLIIIIIIIIIIILLLLILLLIPPPPPPPPPPQQQQQQQQQQTASASTASSTYFFFFYYFFYDDDDDDDDDDSSQQQCQQQQIIFIIIIIIIAAFAAAAFAAASGAAAAAAAKKKKKKKKKKVVIVVVVLIVVIVVVVVVVLIIIIIIIIIICHHHHHHHHHDDDDDDDDDDIKKKKIKKKILLLLLLLLLLPPPPPPPPPPAVAAAAAAAA-------D---------Y---------L---------I---------N---------K---------D---------V---------K---------F---------C---------Y---------R--EEKEEEEKKERRKRRRRKKRLL-LLLL-LLFY-FFFF-FFAA-AAAA-SARR-RRRR-RRAVMMMMMMMMHYYYYHYYYHNNNNNNSNNNDDDDEDDDDD-GSGGGGSSG-NNNNNNQNNDDDDDDDDDDDDDDDDDDDD---------R---------T---------T---------A---------R---------S---------H---------H---------S---------P---------K---------G---------E---------Y---------Q---------K---------AYYHYHYYHHYLLLL-LLLLILLLL-LLLLL

NNHNNNNNNNMMMYGMMTMMDDDDDDDDDDGGGGGGGGGGRRRRRRRRRRSNNN-NNNSNHHHH-RHHHKLLML-LLLPLLLLLLLLLLLFYYYYYYFFYEHHHHHREEHKVVVVVVKKVIIIIIIIIIITKKKKKKKKKGSGGGGSSSGLLLLLLLLLL-LLLMLLLLMVVVVIVVVVVQRQQQEQQQQPPPPPPPPPPAAAAAAHAAAIILIRLIIILNNSNSSNNNSPPPPQPPPPRLIILIIIILIEEEEEEEE-EKTVTTTTK-T-AAALLAA-LIIIIIIIIIINNTNTTNNNTEEEEEEEEEEIPPPGGPPIGSNDDDDNNSDAATTTTAAQTAAAAAAAAAADEEEEEEEEEFMGGGGMMMG

KKKKQKKKKELLLLLLLLLLKKKKEKKRRKMMMMAMMMMAMIIIIMIIIIEEEEEEEEEESSSQSSSQQSEEEKEEEKKEKKKKKKKKKKNNNNSNNNNNIIIIIIIIIIGGGAGGGAAGPPPPPPPPPPVVVVVVMVVVATTTTATTTTMKMMMMMMMMVVVVVAVVVVEDEEDEDEEDDGGGGDGGGGRRRRNRRRRRAAAAAAAAAANNNNNNNNNNCACCCTGCCCVKVFKIKVVKTTTMTTTVITRRRRRRRRRRSSSSSSS-SSEEEQTEEQQTHHHHHHHHHHSSTQTSSQQTEEEEEEEEEELQLLQLQLLLEEEEEEEEEEPPPLPPPHHPKKKKKKKKKKPCPPPPPPPP

SSSSSSSSSSLLLLLLLLLLAGALAAAAAARRRRRRRRRR-------V---------S---------I--TTTTTTTTTTRSNSNKNNNNYYYYYYYYYYEEEEEEEEEEYYYYFYYYYYAALVVAAAVAIIIIIIIIIITTTTTTTTTTFFFFFFFLFLLIIIILIMIMVVVTVVVVVV-------N-NAAAAAAASASADDDSSSSSSKEEEEEEEEEIIVIIIVIVIIIIIIIIIIIDDKDDDDDDDMTMIMMMMMMSTTTTSTTTTGGGGGGGGGGFFFFTFFFTFLLLLLLLLLL-------N-N-------I-V-------L-L-------T-T-------Y-YLIIVILILILKKRKKKREKRLIVVVLVLVLEEEEEEEAEEM-MMMMMMMMK-KKKKAKKKN-NNNNNNNN

AAAAAAAAAALLLLMLLLLMSSSLSSSSSSVVLLLLLVLLAADDDNDADDDDDDDDDDDDKKKKKKKKKKKKKKKKKSKKQQQEQQQQQQRRYHRRRRRRPPPPPPPPPPQQRRKRRQRKQQKKKKKQKKGGAGGGSGSGEQRRRQQQQRVVSAAAEVEAEDASNAADAHKAKKKKKAKKIIIIIIIIIIKKKKKKKKKKVEQQQQQEQQNNDDDDDNDDLLTTKTTLTKIIIVLIIIIIFFFFFFFFVFLFLVLLVFVLDDDDDDDDDDGGGNNGGGGNDDDEDGDDDDSSPPPSSSSPDDNYKNNDNNNNNNNNNNNNAGGGNGGGGNRRRRKRRRRKRRRRRRNRRR------T-T-------L-L-------M-M-------D-D-FFFFLFFFFLSSPSSSSSSSFFFFFFFFFFWWWWWWWWWWSSSSSSNSSNRRRRDRRRRD------G-G-------N-N-------R-R-------H-H-------P-A-------G-G-------S-S-------T-T-------Q-E-------W-W-------E-E-------A-E-------P-P-------H-H-------V-V-TTTTTTTTTTTTMMLMMNMKHHHNNHHHHN

TKTTTTTSTTQMMQMQMMIMLVVLILIVIIPPPPPPPPPPLVVLLLVVVLSTKSTSTTTTAAAAAAAAAAMMMMMMMMMMTTTTTTYTYT-----K---------P---------A---------A---------C---------S---------A---------G---------E----KEEKDEEEEDEQEEEEEEEELQQQQQQQQQNDDNDDDDDDIEEINIEEEITKKKKRTKKKGGGGGGGGGG-D-----D--GGGGGGGGGGIFVIIILVLIEEEEEEEEEEQEEEEEEEEETYYTSTTYTTKKKKK-RKRKRRRRR-TRHRAKPAA-VKVATTTTT-TTTTIIIVI-VIIISEESS-EEESLLVLL-LLLL-KT---TTT--FF---FFF--DD---D-D--II---LIF-IIMII-IVII

LLLLLLLLLLMLLMLLMMMMYYYYYHNYNYLLLLLLLLLLAAAAAA-A--AAVAAV-T--AGGGGG-G--PPPPPP-P---------R--GGGGGGGGGGRRRRRRRRRRAAIAAA-A--DDPDDDDDDDILLLLVMLMMSSPSSPSSSSEEEQEEQQQQQKKKKKKKKKFFFFFFFFFFRRRRRRRRRREEEEEEEEEERR-RRRRRRRGG-GGGNGNNEE-EEEKKKQVV-VVLVVVVGGGGGGGGGGKQARAVKKKKFFFFFFFFYFGGGGGGGGGGGGGGGGKGKRPPPPPPPPPPAAAAAAAAAAGGGGGGGGGG---------S---------ILLLILLIIIILLLLLLLLLL

DDDDDDDDDDRKNRRRNNRRYFFFFYFFFFGAAAAGAAAAQQRQQQQQQQVEEAEVEEEEEEEEEEDDEEKEKKKKKKKKLLLLLLLLLLAAAAAAAAAALLLLLLLLLLTAAAATAAAAIIIFIIIIIISSTSGNTTGSKKNNNKNNNKSIIIMTIIMIFMMMWFLMWMNNNNNNNNNNQQLLQQLLQQ--Q---TT--NGNNNNNN-NLLLLLLMM-LLEEEEVEE-EKKKKKKKK-R-LLLL-LL-LDDDDEDDD-DIMMMMMMM-MEEEDEEQQ-ELLFLILFF-LSSASKSSS-TLLLLLLLL-LLLLLLLLL-LAKKKKAKK-KEEEEEEDE-ETIIIITII-I

QQQQQKQQQQ-----V----SSSSSSSSSSDEEEEDEDEEGGGGGGGGGGSSSASSSSSS----L-----IVVFVILIVLFWFFFFFFFFRRKKRRRRKKDDDDDDDDDDEEEEEEEEAEAAAAAAAAAADDDDDDDDDDNDDDDNNNDDNNSSNNNNNSNNNNNNNNNNAAAAAAAAAAGGGGGGGGGGNNSSSNSSASFFFFFLFFFFDQQQQDEQQQEEEEEEEEPE--LL----LL--DD----DD--IT----IT--AT----ATRRRRRRRRRRKRKKKKKKKKPPPPPPPPPPEDDDDEEEDDDDGDDDDDDDLLIILLLLLIDDEDDDDDDDEEEEEEEEEEVAAAAVVVAAFWWYWFFFWYIIIIIIIIIILLLLLLLLLLEDDDDEEEDEASSSNAMATS--V-------RRNNRRKRRNLLIIILLWIIEPSPPPPPPP

---G----G----Y----Y----I----I----K----K-RRRRRRRRRRRRRRKRKKRKDEDDEEDEEDTTTISTTTSTFFFFLFPFFPAAAEAAAEEQFFFYFFFYYFKPKPPP-PP-LLLLLLLLLLMTTTTTTTTTLVLLVVLLLLLALAAALAALAAAAAAAAAAGGGGGGGGGGPPPQPPPLQPETEVCTDAVDNNNNNNDNNNVTTTTTTTDIRRRRRKRRRRT-TV--VVVTQ-QQ--EQQQE-EE--EEEEQ---------S-ME--TEETL-LI--IIIIEEEDEQEEEESNNASNSSSSATASSTGTTGGGGGGGGGGGFFFFFFFFFFFFFAFFFFFFFFFFFFFFFFVQIVQQIVVIDEDGNDDDGDQQQQQETQQQKTKTSTHTTHGAGESAGEEGIIIIIILIILKKKTKKKTTK

---N---------L---------S---------Y------TTTTTTTTTTNDDSNNNNNNRRRRRRRRRRRRRRRRRRRRLLLYLLLLLILLLLLLLLMLPQQKQQQQRRGGGGGGGGGGTTTTTTTTSTASSSASAASSYFYYYSYYYYNNNDNDNNDKSAASSSSSKSIVIIIIIIIIAAAAAAAALAAAAAAAAAAASDSSDEDDSEEEEEEEEEEEILIVVVIIVVTTTTTTTTTTHHHHHHHHTHSAAASAASAAGGGGGSGGGGAQATATAATT-NNN-NKKNN-AAA-AAAAALLMILMLLLLEEEEEEEEEEAVVVAVAAVISSSSSSSSSSVIIVIIIIAIDDDEDDDDDD

RRKKKRKRRRMMMMMMMMMMDDDDDND--NEEEDEEEEEETTTTT-TTTALLLLL-LLLLLLLLL-LLLLLLIII-ILLLSSKKK-RSSKRRAAA-ARRRIVLLL-LVVIMMQQK-QMMQIIIIL-IIITEDEEE-EEEDLLLLL-LLLLVIIII-IIIILLLLL-LIMLTTTTT-TTKTTTTTT-TTTTVVVVV-VVVVRRRRR-RRRRVIVVVVVIIVAAAAANAAANLLLLLLLLLLSSSSSSSSSAAAAAASAAAFLMLLLILMMI--DDDDD--D--FFFFF--L--KKKKK--K--GGGGG--G--WWWWW--W--TPTTP--T

KKKKKKKKKKQQLQLQQAQQGGSNSGGGNNVMVLVMVIVLVMIIIMVVIIV---------E---------E---------D---------S---------A---------EEEDEEDEEDTNKNKNNNNNFILWWHFFWWIIIIIIIIIIAASSSAAASSTKAAAKTKAAKKKKRKKKKKDNDDDNDNDDVIVVVIVVVVYYYYHYYYYYFFLFFFLFFFLLL-LLLLLVVVV-VVVVVAMMM-MMLMMMGGG-GGGGGGPSSRSSSSSRPSAATSPSAAVVVIVVVVVVRRRRRRRRRREEEEEEEEEEGGGGGGGGGGEEEEEEEEKEPPPPPPPPPPQQQHQQQQQQIIIIIIIIVIEEEEEEEEEEDDDDDDDDDDKIVVVVKVVVMMIIITMLIIPPAGGPPPGG

PPPPPPPPPPIAVLILIIIIDDDDDDDDDDGGGGGGGGGGNNNNNNNNNNAQQQEQQQQQN-DDDDN-DDS-TTTTG-STF-FYFFF-FFD-EDDDE-DDY-Q-H-Y--HE-EEEEE-EEL-LLLLL-LLP-PPPPP-PPT-TTTTT-TTN-NANSN-NNH-HIHIH-HHG-GGGGG-GG----S---------Y---------R---------V---------L-----S-NCACS-SSI-IVIVI-VVY-YTYTY-SYVATATAVAATCCCCSCCCCCYYFYYYYYYYHHHHHYHHHHDQHQHQDQQHQ--V-VQ-V-T--F-FT-T-P--Q-QP-Q-G--G-GG-G-LCFFFFLFFFKSSDSSKSSSEEDEEEEEEDDDDDDNDDDDADDADAADADTATTTTTATIDDEEDEDDADEHQQQQEQQQAAAAAAAAAA

KKKKKKKKKKIIIIIIIIIIVIVIVIVVVVQQQQQQEQQQYYHHYYYYFYKKRRKKRRKKEEEEEEEEEEVVVVVVVVVIVVIVVVVVVVEEEEEEEEEE-V--V------G--G------H--H------V--V------Y--Y------G--G------T--T------D--D------R--R------L--L-----MMVCMMVMMMAARRAARSAAQQQ-QQQQQQFFY-FFYYRRLLL-LLLLLLTSR-TTATTTEED-EEDDDDEED-EEEDEEKRE-KKEEDDDDS-DDNNNNTTT-TTTTTTLLL-LLLLLLNND-SNNNNN-R--RR-----A--AA-----L--LV-----K--NK-----C--CY-----T--TA-----E--EK-----G--GG-----N--NT-----L--LI-----D--DD-----R--RR-----V--VV-----D--DD-----S--SS-----N--NN-----H--HH----SSS-SSSSSSDDE-DDDDDDYYW-YYWWWWKKN-KKNNYYKKE-KKEEEENNN-NLNNNNKEE-EEKKKEYYY-YYYYYYYKY-YYYYYYLLL-LILLIL

RRRRRRRRRRLLLLLLLSLLAEEEAAEEEEKRRERRRERKAAAATTAAATSSAASSSASATTTTTTTTTTLLLVLLLVLLEEEEEEEEEEAVVVIIIVVVTTTNTTTTTKVVIIIVVIVIKSKEKKKEKKLLLLLLLLLLQQQQQQQQQQGGGGGGGGGGIIIVIIIIIISSSSAASPSSLLLYLLLLLLKEEEKKEEEEEEAEEEGEEEGGGGGGGGGGFFFFFFFVFFKSTTSSTTSTKKKERRKEKQEEEEEEEEEEDDNNNNDNDNVVVQVVVVVLTKTTTTETTTQQQQQQQQQQTEKQTTQQQNTTTTTTTTTTGGGSGGASGNAAAAAAAAAAIIIVIIIVIVEEQQEEDQDQLLLLLLLLLLNNNNNNNNNNTTTSTTTSTSDVEREEEREREENNEENNNNQQQQQQQQQQRRRRRKRERREESSDEASAS

AAAAASAEAAAKAAKAAAAAQQQQQQQQQKLIIIILLLIIHHHHHHHHHHSQSSSSSSSSKCS-SSKKS-GDG-GGGGG-PPT-PPPPT-KAS-AASSA-WWW-WWWWW-RRR-RRRTR-ASASSAAAASEEEEEEEEEEDDGDDDDDSGEEEEEEEEEEVETTSTVTRTSSESSSSTESEEEEEEEEEEFYYYYYYYYYKQEQQQLTERLLLLILLLLLNNNNNNNNNNAVVVVVAAVVGGGGGGGGGGIIVVIVIIVVAVAVVVVVAVRERRESRNRRTTVTTTTTVSKRKKKKKKKKVVVTVVVVVVTTTVSTTTTVAALLAAALLLVVVVIVVVVVCCVCCCCCVFTTTTTTTATTRSVSSSRSIEEAEEEEEEEEAAAAAAVAAAIVIIIMIIIIRRRRRRRRRRYYYYYYYYYYFFFFFFFFFFTTCCTTTTCC

IAVVVVVVVVRRRRRRKSRRLLLLLLFLLLDDDDDDDDDDNNNNNNNNNDAATTTATTVAFIIIIFIL-FLLLLLLLL-LPPPPPPPP-PSAASASSE-SQQKQEQQQ-QFFFFFFFF-FFIIIIIII-LRRRRRRRR-RIIIIIIII-VLKKKKLKKKKTVTTTTTTVTAAAAAAAIAAFFFFFFFFFF-SSSS-SSSSTQSSSTSSQSIIIVIIIIIITVSSSTSSVTVVLVLVVLVVEDEDEDDDDDAAAAAAAAAAQRRNRQRRKKLYLLLLLLLLVLLLILLLLLLFFFFLFFFLMIMIMMIIIMNGGGGNGGGNFFFFYFFFFFV---------VVVVVVVVVV

VVLFVLLLVLHHYYHYYYHYLLVVLLIVLVLLLLLLLLLLKKKNKKKTKKFFFFFFFFFFVVVVVIIIVVVVVVVVVVVISSSSSSSSSSFFFFFFFFFFWKKKLRKKWKDDEDDDDDDDIIIIIIIIIIVVVVVVVVVVQQQQQRQQQQYYYYYYYTYYGGGGGGEGGGRRRRRRRRRRDDNNDNNNDDFVVVFIVVFVVVVVIVIIVVGGNSGGGGGGHHHHHHRRHHLLLLLLLLLLSSTSSSSSSSIIIIIIIIIITTTETTTTTHGGGGGGGGGGIIIIIIIIIIIIIIIIIIIIIIIIIVIIIIGGGGGGRGGGAEEEAETIAEKKKKRKKKKK

DDDDDDDDDDKKKKKKKKRKVVVVVVVIVIPSPQPQPQPEHDHDNDDDDDEEEEEEEEEEAAAAAAAAVAL-L-------KRKRKRKRRRNNNNNNNNTKAGGGGAGAGAIIINITITIT-D-D-EEDED-Q-E-EEQEP-G-G-GGGGG-I-I-IIIII-T-T-STTTT-R-R-RKLKR-M-M-TMMMM-S-G-N-N-D-V-V-A-A-V-G-G-G-G-G-N-N-K-K-K-S-S-S-S-S-F-F-F-F-F-H-H-N-N-N-C-A-FCFCC-D-D-EDEDE-V-V-TVTVTEKEKKKKKKKAAAAAAAAVATTNTTTTTTTGGGGGGGGGGHEEEEEEDEEYYYYYHYHYHIVLIIIVIIIDDDEDDDDDDTSTSASSSSSIVIIIIIIIIFFFFFLFLFFILLILLLLLLTTTITITITISSSASAFSSSTTTTTTTTTTGGGGGGGGGGEKEKEKEKKKDDDGDGDGDGLVLILVVVVVPPPPPPPAPPDMDMDFAFALTTTTTTTSTTRKRKRTKKKK

KKKKKKKKKKDDDDDEEDEDNNGSSGGNGNMMMMMVVMVMQQQQQKQQQQKKKKKKKKKKASAAAAAAAA---LL--------RR--------LL--------II--------LL--------II-----PSPPPPPSPPPPPPPPEPPPYY-----Y--TT-----T--SA-----S--SYYYYYYYYYPPPPPPPPPPMQLLLLLMLLVVVVVVVVVVKKKKKKKKKKKHHHHHHEHHLILIILLILLGGGGGGGGGGLQHEEHHHHQSSTTTTQSMTIIMSTMMIMTRRRRRRRRRRATTTSAAIATRRRRRRRRRRAAAAAAAAAAKKERKEEKEKNNNHHRNNNNRKRRRRARARRLIIVIIIIIVTKTHKKTKKIIIIIIIIIL--PPPPP-PPLILMLLILLLKKKDHKIKMKSSSSSSSGSSII-IIKKIKKEE-EEEEDEEAA-DDAAAAADD-HHNNDND

EEEEEEEEEEFFFFFFFFFFDDDDDDDDDDAASAAAAAASKKKKKKKKARRRRRRRRRRRDYDDFDEDEDLLLLLLLLLL---E----E----A----V----S----S----W----W----T----T----H----R----E----E----V----V-YRYYYYYYYNTSTMSSTTTTKKAKKKKKKANNNNNNNDNNTTTTTTTTTTIAIVAVVVVISNQSNNNNSSQQQVQQQQVQEEEEEEQQEESQSSASSSSSHHHLHHHHLHRRRRRRRRNRDDYDDDDDEGKKKKKEKAKQHHHHHHHHHHQHQQHQ--QQPPPPPP--PPPPPPPPPPPPWWWWWWWWWWKKKQKKQQKKYYYYYYYYYYSASSASGGSSLLLLLLLLLLFFFFFFFFFFKKKKKKKKKKQQQQQQQQQQQQAQQQQQQQVAVAAAAAAVFYFFFFFFFFHHHQHQHHHHPPPPPPPPPPNSNDSSRRDNLMI-MMMMLIGGG-GGGGGGRRL-QRNNRLVVV-VVAAVV--------C---------K---------D---------N---------K---------D---------Y---------V---------Y---------N---------R---------Y---------D---------Y---------M---------L-RRR-RRRRRR

KKKKKKKKKKLQQQQQMQQQAPPPPPPPPEFFFFFFFFFFAAAAAAQAGAQQQQQQQQEQDDDDDDDDEDDNDASSDTSGLILIIILIIIEEEEQEEEEEGGGGGGGGGAVVVVVVVLVVPPPPPPPPPSEEEEEEEDDEASAAAAAAASRRRRRRRRRRKVTVVTTVVVQQEQQQQQQQNNNNNNNNSNIIIIIIIIIIYYYYYYFYYYFFFFFFFFFFIIIIVVVVVIDDDKKDDDDDTGEAAAEAAAQQQQQQQQQKQQQQQQQQQQFFFFFFFFFFIRIRRRIRRRSSSNNNSSSSNKNNNNHYYNKKRKRKRKKKTTTTTTTTTTHHHRRHHHHHIVIVVVIVVVPPPPPPPDPPLFLLLLLLLLTTTTTTTTTTSDSDDDSDDDVVVVVVLVVVKKRKKKKKRKMMMMTMMMMMFFFFFFFFFF

RESRRSSSSSQEQEQQQRQQNRGNNGGGGGAAAAAAAAAAGGGGGDDEDDSSSSSNSSSSWWWWWWWWWWGGGGGGGGGGDEDDENDNNDSSSSSESEESFFFFFFFFFFDDDDDDDDDDDEEEESSSSSKKKKKKRKKRYYYYYYYYYYTTTTTTTTTTIIIIIIVIIIEEEEEEEEEERRKRKNNNNNNNDNNENENNKKKKKKKKKKLLLLLLFLLLKKKKKKKKKKDEEEEEEEEELLLLLLLLLLGGGGGPGGGGHHYHYKQQQQQQQQQYYYYYFFFLFFWFFWVVVVILVVVVGGGGGGGAGGEEEEEEENNEFFFFFFFFFFVVVVVVVVVV

IIIIIIIIIISNNNASSNQNDEDDDDDDDENSNANFDSSSRRRRRRRRRREEEETEEEEEQQQQQQQQQQNGNGQNNGGGLLLLFLLLLLAAAAAAAAAAENNNEEENNNNLNFNNNNFDEDDDNDDDDD-----P---------K---------S---------N---------R---------N---------P----A---AAA---Q---QQQ---K---KKK---K---KNN---P---PPP---C---CCC---N---NNP---A---PRR---L---LLL---V---TTT---RVRARRRSASQKKRKAQKKKMTMTMLLTTTRQRQRRRQRQLLLLLLLLLLVMVVVVVVVVDEEEDDDEEEGGGGGGGGGGQERQQQQQQQQQQQQQQQQQNQNNNTTNQNATATTAATTTRRRRRRRRRRKKKKKEAKKKRHRHRRRHHHVVVVVVVVVVAAAAADDVAAAAATAAAAAAVLLLLLLLLLSASSSSSSSSKKKKKKKKKK

SSSSSSSSSSFLLLFLSFFLSQAASASSSAQNQQQQHQQQTKKKRKTKKKAVVVVYAVVVERRRRREEERDDHDDRDDDDAAMAASAAAAFFFFFFFFFFQSESQEGQQSKKKKKKKKKKRKKKKKRKKKKKKKKKKKKKKKKKKKTKKKPNNNKNPKKNFVVVLIYFLIAAKAAKAAAAGGGGGGGGGGVCCCCCCCCLKKKKTKKKKKSLLLSLSSSLNNNDNNNNNNSTTTSTSSSTNNKNNKNNNRTSASSAITTSYKRKKKYYHKEEEEEEEEEEHFFFFKHHYFLLLLLLLLFLEEEEEEEEEENNEDDDDDDDVIIIVIVVVIEEKEEKDEEE

GGGGGGGGGGKKKKKKRKRKSSSSSSSSSSAKAKAAAKAKPPGPPPPPPPFFFFFFFFFFIIVIITIIVLYYYYYYFYFY-D-D---D-DLLLLLLLLLLCCCCCCCCCCWWWWWWWWWWLLILLLLLILDDDDDDDDDDLILLLLFIFIAAAAAAAAAARRRRRQKRKRILIFIVLLIIDEDEDDEEEEAAAGNAAAAANNNNNNNNNNDEEDDETETEA-A-AA---AKKKKKKKKKKRARALRRARRGGGNGGGGGG-E-E---E---L-L---L---M-A---M---N-N---N--RRRRRRRRRRWWWWWWWWWWTTTETTTTTTLVIAVIIVIVTATTTTTATSNNNNNINNNNKNKNKKKNENTTTTTTTTTTVVVVVI-VVV

LLLLLLLLLLIVIIIVVIIIYYCYYFYYCYPATKKTTTTTMAMMMAAAAAMLMMMLIVMVLLLLLLLLILTVVVVVVVVVGGGGGGGGGGRRRRRRRRRRRTTTTTTTTTRQR-RQQDQNFYYYYYHYYYEEEEEKEEEETTTTTTTTTTGGGGGGGGGGVLVVVLLLVMEEEEEEEEEERKRGRRKQRRSSSSESSLSTAKAAAAKKGKLIIILIIIIITAASTAAAAAGAAGGAAACALIIILIVIVISSTNSSPPSPLLLLLLLLLLSKTSSKKKKAEKEEEEMMEMYMYYYYFFYFLIIIIIVLIVVIVVVVLLVLFFFFFFFFFF

YYYYYYYYYYEEVREEEEERMMIIMMMMMIFLLLLLLLLLAAAAAAAAAAKKKKAAKKKKEEEEEQEEEEYYLLYCYYYLRRRRRRRRRRQQNNNNNTTNNNDDDDDDDDIIIVIIIIIISSNTSSTTTTLLLLLLLLLLSSSSSSAAASAPPPPPPPPPPPPPPPPPPPQQEEHHQQQEGGGWGGGGGGGKGGGGGAGGPKKKKKKKKKGGGGGPGGGGQAAAPPRRRAVVVEVVVVVVHFHHHHHHHHKRKKKKEKKKCVCCCLCCCCQQQQQQQQQQKKKKKKKLKKPPPPPPPPPPFFFYFFFFFFHYQQKKEEEQQQQQQQQQQQ

GGGGGGGGGGAAAAPAAAAAASASASAAAAAAASAAAAAAYFYYYHFYYFIIIIIIIIIIYFYFYFYYYFASAAAAAAAALLLLLLLLLLNNNNNSNNNNFFFFFFFFFFHNSHHHHHHHIIIIIIIIIVATAAAAAAIASAAAAAAAAADEDEEEDEEEKKKKRRKKKKVVVVVVVVVVRGNNNNDHNSYYYYYYYYYYKKKKKKKKKKVVVVIVVLVVNGNGNGGNNGGGGGSG-SS-QQKQQQQQQQVVVVYIVVVVTTTTTT-TS-QQQQEQQEEQSQHQHQHHHHHRHRRRQRRQLLLLLLLLLLLSSSSSSSTSKKKKRKKRKK

AEEAEQAAAQPPPPPPPPPPSNSSSSSSSSYYSYSYYYYYSQDQDDRQQDRRTRTRRRRRRRLLLLLLLLTQHQHQQRQILLLLLLLLLLYYFYFFYYYFSSASAASSEAAAVSVVAAAIDDEGQEDDDEQQQQQKQQQQKKKKKKKKKKEEIQIIQEEITTTRTTTTTTMMVIVIIMMIKKKKKEKKKKDSKTKVTTSVTTTTTTTTSTQQREREEQQEGGGGGGGGGGDDDDDDDDDDLLLLPLLLLLTKSTTTTTTTRRRRRARRRKPPPPPPPPPPQPPPPPPPPPSSTTTTTTTTFFFFFFFFFFYFFYYYYYYYGGGGGGGGGG

KPPPPAPPPPIIVIIIIVIITSTSTTTTTTLLLLLLLLLLLLLLLLLLLCMLMLIIIMMISSSGSSSSSSLLLLLLLKILSTGSSSSGSSTTTTVVTTTVHNHNHHHHHHEDEEEEEKEEIIIIIII-IIIIIIIIIIIIDEEEEEEEDEKQKQQQQKQQEEEEEEEEEDNEEEEQEEAQAMMMAMMMMMSSSSSSSSSSEDEDDDDEEDEVAVVVVAAVD-D----DD-AAAATTAAGTLLLLRRRLLRNNDNNNQDQNFFFFFFFFFFDDDDDDDEDDGGGGGGGGGGTSSSSSSSSPEEEEEEEEEERRRRKKRRRKVVIVMVVIKV

YYYYYYYYYYAPPAAPAPPPVVVVVVVAVVCINCCMCCMCIIIIIIIIIIILLIILILLLAAAAAAAADALLIIIIIILIRQRRRLRRQRNSNDDNNQNNVVVVVIVVVVEEEEEEEEEETTTTTTTTTTNSSSSSNSSSMALLMMMLMLQKQLQQQQKQLVIMMVLIVIAIVVVIAVIVHHHHHHHHHYQRQQQRQRRQRNQRRNRNNQTTITTTVTTIQQQEEQQSQQLIILLILVIIYFGYYYYYYGFFFFFFFFFFESEEEEEEDEDDDDDDDDDDKAKRKKKKEKSASNAASAASAAAAAAAAAPYYYYYYYYYYMMMMMMMMMM

AAAAAATAAATTTTTTTTTTRRRASRRRRRSSFSSSFSSFAAAYAAAAAARRRRRRRRRRKKKRTKKRIKHHHHQNNNNNVVIVVIIVIIYYFYYYYYLFLLALLLLMLAAAAAAASASAGGGGGGGGGGEEEEEEEEEELLLMLLLLLLAATASAAAAALLLLLLLLLLKKKKKKKKKRKKKKKKKKKKLLLLLLLLMLCCCCCCCCCGSSNCSSSSSNLLLLLLLLLLAAAAAAVAAAIVVVVVVV-VLLLLLLLLLLDDDDDDDDDDVAASSAAAAASSDGGEDEEDFFFFFFFFFFGGGGGGGGGGVVVVVVVVVVIIILIIIIVI

PPPPPPPPPPRKRRRRRRRRGGGGGGGGGGLLLIILLLLLQQQQQQQAQQIIIIIIIIIIHHHNNHHHHHQPPPPPPPPPLLILLLLLLLEEEEEQEEEEPPPPPPPPPPSSSLLLSSSF--------M---------I---------F---------I---------G---------N---------G---------R---------S---------A---------P---------T---------A---------N---------Q---------G---------D---------S---------V---------F---------Y---------L---------A---------L---------V---------E---------V---------P---------N---------S---------T---------G---------S---------L---------I---------N---------K---------V---------S---------G---------F---------T---------A---------Q---------A---------A---------S---------H-IIIIIVLVIVAAAAAAASAAGGGGGGGGGGGGGGGGGGGGTIMMMMIVMMSSSSSSSSSSKAAAAAASSALLLLLLLLLLEEEQQEEEEEDEEEEEEDEEMMMMMMMMMMTAATTTATTTTIITETITTTNSNNDNNNNNDGGDNDGDDDKKKKKKKKKKIAATTTAITTKTTSTTTQSTEEEEEEESQEYYYFFRYYYRGGGGGGGGDG

VAAAAAAAAASCCCCSCCCSEEEEKEEDQEITIIIIIIIIIVVVVIVVAVWWWWWWWWWWNNNNNENNNNPPPPPPPPPP-----V----STSTTSSTTSGGGGGGNGGGLLLLLILLLLGGGAGGGGAGSSQSCSQSSTPAPPPPPAPPQKRRKQRKRKPPPPPPPPPPSSSSSSSSSSVAMVVVRAVVILLLLILLLIVVVVVVMVVVMMQIMMMMIIRRRRRRRRRRPPPLPPPPPPLLLLLLLLLLGSSSSSSSSSHHHHHHHHHHLLLLLLLLLLEKKKKKRKKKIIIIIIIIIIDDDDDDQDDDEEEEEEEEEELFLLLLLFLFPPPPPDPPPPQQAQQTSQQQEEEDEEEEEENGKGNNGGGN

SESEASGESTEEEEEEEEEE------I---ERSRRRRRERLLLLSLSLLLEEEEEEEEEEKKKKKKKKKKKKKKKKKKKKDSNTNNNTDNLLLLLLLLLLQQQG-Q-QHQEEEEEEEEEECCFVCCCICCGGGAEGDGGGIIIIIIIIIIVVVVVLIVVVHHHHHHHHYHKKRKKKKKKRQEEEEEEEEESSSSSSSSSAKKKKLSKKKKTVVLCTTVTVSGSSSCSPSSLLLLLLLLLLVIIIIIIIVINNNQNNNQNNRRKNKRKNKKTVVVTTTVTAWWWWWWWWWWTAAASSTATVPPPPPPPPPPQQQEQQQQQQYQQQHYHQYQAASSAAAAAA

EHDEDEDDDELLLLLLLPLLVVVVIVVVVVGGGGGGGGGG---------V---------V---------K---------P---------E---------E---------L---------D---------K---------T---------S---------I---------Q---------KLLLVLLILLLQQQQQEQQQQPPPPPPPPPPFFFFFFFFFVIIIVVIIIII-VL-LLLLLL-ND-NNDDGG-TT-TTTTST-RK-KRKKRRTATTTATTTT-T---S--SS-P---P--PPKKKKKKKKKKKKKKKKKKKRDDDDDDDDDDLLLCLILLLLTTTTVTTVTT--V---V---IIIIIIIIILVSTVTSTTTTEEEEQEEQEKACAAACVAAANSNNNNNNNSQQDQQQEQQQAAAAAAIAMMCCYCYCYYCCEEE-EEEEEEGGG-GGGGGGTAT-TATTAASSK-SSSSSS-I---V--KKSSS-SSSSSSHPP-PPPPPP

VVVVVVVVIIEEEEEEKEEEEEKEEEAEEESSSVSSAAAAIIIIWIIIII-----E---------Q----QEKQAAKKKKTTTTTTTTAQGGGGGGGGGGTSSTTTATTTLLLLLLVLLLGNNGGGNDNNDDDDDDDDDDMVMMMMMMMMSSSSSSSSSSLLLLLLLLFLG-GGAAGGAAF-LFFFMIMMTTTTTTTSSSPPPPPPPPPSSHHSSTHQHHKKKRKKKKKKLVFLLLIILLLWWWWWWWWWYYYYYYYYYYGGGGGGGGGGIVVLVVVIAVQQQQCCQQQQAAAAAAAAAATNNNNDNNNNMLMIMMSAMMPPPPPPPPPPV-VVVVVVVVI-ILLLLLLLM-TMMMMMMMA-SAAAAVVVP-SPPPETSSP-PPPPPPPP

---L---------D------KKEEKT-EKKFFFFFFFFFFTTTTATTTTSYYNNYYYNYYFFFFFFFFFFAAAAGAAASATTTTSSSTSSDDEEDDDEDDVVAAVVVAVIKKKKKKKTKKDDDDSSDESGKKKKQQRKQQEEDHEEEHEEYYFFYYYFYYIIIIIIIIIITTTTVTTTTTIVILAIIIIILLCCCCCCCCSSSSYYYSYYSPPPPPPPPPFFFFFFFFFFAAEESSAESSAAAAAAAAAAAAVAGVVAVVHHHHHHHHHHHHHHHHHHHHDDDDDDDDDDSSSPSSSPSSGGGGGGGGGGNNNNNNNNNHDDDDDDEDDDRRKKKKKKKKVVVVVVVKVV

LLLLLLLLLLVTTVVVVSTVKSSSSNSSSEAAAAAAAAAAVVVVV-VVVVEQQE--EQQETIVT-TTIITGGGG-GGGGGEALA-AAAAAVIVVVVVVVVSSSSSSSSSSKKKRKKKKKKYLLLLLFLLYSSASASSSSADPPDDDDPPDPPPPPPPPPPCCFCCCCCCCVLLMAALIIVEEEEQQEEKEGGGGGGGGGGHHHHHHHHHHGGGGGGGGGGQQQQQQQQQHEEEEEAEEEEGGGGGGGGGGSSSTSSSSSSMMMRRRMMMWKKKKKKKKKKKRKKKKKKKK-----R---------T---------A---------Q---------L---------I---------L---------L---------K---------A---------T---------F---------Q----GSNGGGGSSGNKIIIMNIINIVVVVVVIVVNWWWWWWWWHWWWWWWWWWWASSSSSSSSAPPPPPPPPPPHNNHHHHNNH

FLLLLLLLFLQQQQQQRQQHKSSSSSSSSSTSTSSTSTTTPPPPPPPPPPKKKQKKKKKKEEDEEEEEEEPPPPPPPPPPQKKKKKKRKKQQQQQQQPQEFFFFFFFFFFFQFQAMQMFFVTILVVVVVVGNGNNGDGGGNSNSSSSDNNEEEEEEEEEETSQSSENQRQPPPPPPPPPPWWWWWWWWWWVPAPAAAAVVQQQQQQQQQQ-------T--RKRKKRRRRRQEQEHHHQQQAEREEKEKKKAAAAAAAAAALFYFFHFFLFAAAAAAAAAADRRRRKREDETTTTTTTTTTLLLLLLPLLLLLLLLLLLLLCCCCCCCCCCKQKQQKQKKK

KKKKKKKKKKSSGSSSSSGS--E-------SNNNNNNSNNLILIIIILLIRQRRKRRRRPLLLLLLLLLLLILLLLLILLMMLMMMMMLMPPPPPPPPPPQQQQQQQQKQVVVVVIVVVVFFFFFFVFFFDEDDEDDDDDEQEEQQEEEQVIVVVVVVVVDDDDDDDDDDSQTSSSSSASQQQQQGQEQGEEEEEEEEQEMMMMMMMMMMGTGGTTGGGTPPPPPPPIPPFFFFFFFFFFDDDDADDDDDATATTTTTAIVVVLVVLIVVAAGSSDSAADRQSEQQERSQRKRKKPKRRAVVIVVVVTIVPPPPPPPPLPPPPPPPPRPPFFFFFFFFFF

ININVNVIINIIILITIIIIAAAAAAAAAAKKKKKKRKRKPPPPPPPPPPTTTTTTTTTHILIVIVIIIIRRRYRRRRRREKKKKKKENKIIIIIIIVILAAAACACACAEDEDLEEETD----E-E-------K-K---YYYFYYYYYFVVTIAVAVVVAAAAMAMAMAAAAASASAAAVVVVVVVVVYHYYYYHYHYYKKEKKKKKKKKTTCTTTKTTHHHHHHHHHHKAKAQAQKHAHSTSRSRHTTYYYYYYYYYYLSLTATLLLTVVVVVVVVIVATAAAAAAAARHRHRHRHRHEDEEEDEEEDVIVVVIVVFISSSSSSSSNS-L-L-L---LAAASASASASSSSSSSSSSS

GGDDDGDDGDAADDDDDDADKKRRRKRRKRQKRKRKTTKRVLLILIIIVLGGGGGGAAGGMMFMYMCCMFQKKKKKDKQKHHHHHHHHHHNNNNNNNDNNEEEEEEEEEEIIIIIIIIIITSAAAAVATAGGGGGGGGGGYYYYYYYYYYLLFLFLLLLFDDDDDDGDDDKKRKKRKKKRVVVVVVVVVVDDDDDDDDDDVLVIV--IIVASASA--SSALLLLLL-LLL-AEAEA-AAE-KLLLKLLKI-TQQQQQQVQ-TTTTTITTV-DDDTSDDDD-RHRHRRRRH-GGGGGGGGG-TQEETEETE-TTTTTTTTT-TTTTTQTTT-STSSSTSSS-MMMMLMMMM-KKKKKKKKK-RRRRRRRKR

DNDDNDDDDDESEEEEEEEEGGGGGGGGGG-------V---------V---------A--VIVVVVVVVVEEEEEEEEEE--------T---------L-PPPPPPPPPPDDDDDDDDDDSTTTSSSSTSHHYHHHHHHHLMF-LLLLLLNTN-NDNNNNSSS-NSSSSNFFL-FFFFFFMMM-MMMLAMFFF-FFFFFFIII-IIIIILASA-AAAAAASAA-SASAAARRR-RRRRRRVVV-LVVVVVEEE-EEEEEEPPP-PPPPPPHEH-HHHQNHWWW-FFWFWFLLL-VLSLLVGGGGAGGGGGEDDDAADADASSSSSSSSSSESSSEEEESEEEEEKEEEEKRRTRRRRRRR--PP----P-AAAATTASADIIIIIIIIII

IFLLFLRIFRTTSGTTTSTTKKKKKKKKQK-V--V---V-DSDDSDTDTTSSSSSSSSSTDDSDDDDDDDAAAAAAAAAADGTDGDSDNQDDDDSDDDDDEEDDEDEEEEIVVVVVVIVV-----V---------V----QEKQEQQSEQLLLLLLLLLLAGGGGGGKGGCCCCCCCCCCRRRRRRRRRRVIVVIVVIIVDDDDDDDDDDRKKKKKKRKKMTLLTMTMTTDDDDDDDDDDYFYYFYYYHYPPQPPPPPPPCCCCCCCCCCNNNNNNDNNDNNTTNNDNNDAAAAAAAAAANENNENDNQDTTTTTTSTTTRRRRRRRRRRAAGAKAAAAEAEAAEAAAAALLLLLLLLLL

ASAAAAASAALLLLLLLLLIEEEEEEEEEEMMMQMMMMMMAEAEEAREEQRRRRRRRRRRGEG--G-G--VVVIVVVVIIGQGGGGGGGGIIIVIIIIIIYNYHNYNNNDNNNNNNNNNNLLLLLELLLLRRRRRRRRRRGGGGGTGGGGSVCIVTVVITMMMLIMLMLLEEEEEEEEQEVVVIIVIVIIKKKKKKKRKKHHHESHQHQQGDGDDDDDDDDSEDDEDDDENNSNNNNNNNHHHADHHHAALSLLLLLSLLEEEKKDKDKKTTATTTTTTTKKKKKKRKKKDDNEEDEDEEAPAPPPPPPPLV-VVLVVVVIIIIIIIIIIASATTSTTTTAAAAAAAAAA

KKKKKKKKKKLLLLLLLLLLEEKKEEKDEESSSSSASSSSIIIIVIIILIRRRRRARRRQFYYYFYYYYFEEEESQEEESQQEEHQEQEHIVVVVVVVVVSSSSSSSSSQHHHHQHHHHHDAGGGDGGGGDDDDDDDDDSGGGGGGGGGGGNGGGGGNGGAATSSASASSKRKKRKKRGRQKQQQQQQQQRRRRRRRSRRDDDDDDDDDDEDDNDEDDDDRKKRKRKKKKIIIIIIIIIIQEEEEEEEEEEDDDDEDDDDEEEEEEDEEEPPPPPPPPPPPPPPPTPPPPIIIVMIIIIIIIIIIIIIIITITTTTNTTTQENQEENEQEKRTKPKMRKRNGGGGGGGGGSGGGGGGGGG

NNNDNNNTNTSSSNTNNSTSGGGGGGGGGGGGGGGGGGGGARRSRSSRSRCCCCCCCCCCEEEKEEEEEELLLLLFLLLLYYYHYYHYYYIVIVIVVVVVVHIVVVVHVHGAAAAAASASILIILIIIILNSNNNNNANNHHHEHHHHHSSSSSSSSSGSRRRRRRRRRREQQQWQRQQQYHYYYYRHYHKRTTTTTRTRNNNSNNSNYNVLLLLLLLLLLLLILLILILYYFYYYYYYYSSSGSSGSSSAASAASAAAA-----L--V-KKKKKKPIKVKKKKKKKKKKHHHHNHHHHHIIVEVVTIVITKTTTNTKNKCCCSCGSCGC--D---------Y-------GGGAAAAGSGKKKRKKKKKKSSSSSTSSSSEEEEEEEEEETTTRLTRQTT--Y-Y-----DDDDDDDDDEEEEEEEEEEEVVVVVVVVVLRRRKRKNRKRF---------ILIIIVIIIVFFFFFFFFFF

HHHHHHHHYHGGGGGGGGGGSSVSSSSSSSRRRLLRRRLRTTTNNNTNNNNNNNNGNNNNKKREAEEEEEIIIIIIIVIIYYYYYYYYYYIIIIFIIIIIQQQEEQQQEQLLLLLLLLLLQEEEEEEEEEFFFLFFFFFFDDDDDGDGDGLLLLLLLLLLMMMLLMMMLMAAAGGGAGGGQRRRRKRKRKTDTTTRTDTTSSSAAAVAAAMIIMLLMLLLAAAAAQAAAALLLLLLLLLLEEEEDEEEEEPPSPPPPPPPKKKKKQKKKQAAASAAAAAASSSSSTSTSTGGGAGGGGGGNNNNNNNNNNLLLKKLLLKL

GAGAGGGGAARRRRRRRRRRETEKEEEEEEQQDQQQQQKQDDDDSDEDDDRTHTMRHMTTRRRRRRRRRRMMMMMMMMMM----T--T--GGGYGGGGAGTTTTTTTTDTRKKKKKKKKR---R----R-TYTYTTTTYY----L--L--TSTTTTTTTSGGGGGGGG-GEIVVVIVV-I--E-------LLLLLLLL-LEEEE-EEE-ECSCA-CCV-CSS-S-S-S-SCC-C-C-C-CPP-P-P-P-PSSTE-STS-SLIII-IIL-INNNN-NNN-NSSSS-SSS-SLLIL-IIL-LIIII-III-ILLLL-LLL-LILIL-III-LAAAE-AVA-AGGGG-GGG-GAAGA-TAA-AGRDD-DDGDRGGGG-GGGGGDDSD-STDDDQKQK-QQEKKCYTFCTTCKFIR-VT--IVATA-TT--TTTQH-QQ--QQQAE-EG--GEEIV-TI--ITV

PPPPPPPPPPSSSSSSSSSSPPPPPPPPPPIIIIEIIIVIEEEEEEEEEEVVVVVVIVIIQQQQQQQQQQDDDDDDDDGDHHHHHHHHHHKKKTTKKKKKVVVVLVVFCVLLLLLLLLLLEEEEEEEEEEAVVIIALALLILLLLILILLIIIIIIIIIIFFFFFFFFFFWWWWWYEYYYYYHYYYYYYYIVLIVIVIVVYYFYYFYYYYLVIIVLVLVVPPPPPPPPPPDDEDDDDDNNDRRSSDRDKKNSSSSDTNTLYYYIIYYYYFVVIVVVVAVVGGGGRGGGGGDDDNDDDDDDSASSGSASAASGGSSSGSGGNHNNNSNNNNAAAAAAEAEEAAAAAAAAAARRRRRQRRRRVVVVVVVVVVGGGGGGGGGGTTTTTTTTTTRKKKKKKKKKYFYYYYMYLLMMMMMMMLMMPPPPSPPPPP

LLLILLLLLLVAASSVAAAATTTNTTTTTTFFFFFFFFLFMMM-FMLTLMGGGGGGGGGGILTLMVIITIVVVVVVVVVVNNNNNNNNNNLLLLLLLLILFFFFFFFFFFEEQEEEEEQEKQKKKKKKKKAAAAAAAAAARRRRRRRKRRNSSAANNNSNVVVVVVVVAVTTTAATTTTTRRRRRRRRRREAARRESAAAFYYYYFYYYYSTASASSRASVVVSCVVVVVSFFFFSSSFSRKKEERRRKRNRS--SSSSCFFF--FFFIFIII--IIIIIKNN--KKNNKHLH--HH-HHLVI--IIIQISSD--SSSSS

AAAAAAAAAAQQQQQQNQQQEEEEEEEEEEGGGGSGGGGGDQDQQQDDDQVIIIFIIAIISSSSSSSSSSQKAKKEAEAELLIMLLILLL-S-SSN---S-K-KKK---K-----T---T-D-NND---E-P-PPP---PDDDDDDDDDDNPPPPPPPPPGTTTTTTNTSGGGGGGGGGGNDNDDDNNNDDDSDDDDDDD-D-DD------D-DD------T-TT-----QQQQQQQQQQPPPPPPPPPPVVILVVIVVVSSSSSSSSSS------Q---ITVVVVIIIVLCLCCCLLLCASASTAAASARRRQRRRRRRIIFIIIFIFI-----D---------G---------L---------L---------E---------L---------G---------K---------E---------N---------E---------I---------L---------S---------D---------L---------E---------L---------N---------Q---------V---------R---------F---------E---------A---------A---------G---------H---------R---------T---------C---------A---------Y---------D---------Y---------K---------R---------K---------G---------T---------Q---------R---------H---------I---------E---------L---------T---------H---------K----NHDHHHNNNHGGGGGGGGGGRRKRRRKRRRRRRRRRRRRRIIVTTILIIICYCCCCCCCCDNDDDDDEDD

YYYYYYYYYYPQPPPQQPPEFFFFFFFSAFMMMMMMMMMMSASSSVSNNAALAAALLMMLSSSSSSSSSSDDDNDDDDDDRRRRKKRKKRPPPPPPPPPPKRKRKRRKKKRRRRRRRRRRTHTSTKTSSK--------L-TNTNTCTTTCCCCCCCCCCCQQEQEQQSEQLLLLLLLLLLDEDDDEDDEEEEEEENEEEEVVVAVVVVVVEEEEEREEER-----P----ILIILLIIILDDDDDDDDDDILIIILIVILGGGGGGGGGGYYYYFYYFFYLLLLLLLLLLPPPPPPPPPPSTSSSITSSIQQQQQQQQQQEEEEEEEEEEKRKRKKRKKKLLILILIIILGGGGGGGGGGVLVIVIIVVIAAAAAAAAAAGGGGKGGK-GPPPPPPPP-PVIVVVVVV-VTLATALTAALVVVVVVTVVVLLLLLLLLLLLLLLLLLLVL

DDDDDDDDDDDDDNSSNNKSMMMIIIIIIILLLLLLLVLLYHYHYYYYYYEEEDDDDEEDQQQQQQQQQQNRSRRRRRRRKTTTTTTTTTKAEKHKKKKKIIIILRIVMLVIVIIIIIIIPPPPPPPPPPSSSSSSSSSSFFFYQQWWWQKKKLLLLKKLLLLRRRRLLRSSSSSSSSSSSNNNYNNNNYDDEDDEDDDDSSSTADTNNSYYYYYYYYYYRRRRRRRRRRAAAAAAAAAAGGGGWGAGGWMMMMMMMMMYEEENNNNNNNGGGGGGGGGGKKKRRRRKKRVVVVIVVVVVKKKKKKKKKKAAAAAADAASTTETPTTTTPPPPPPPPPPPGKGQQRQRRQSSSQSDSSSALLLLLLLMLLPPPPPPPP-PRRRRRRRRRRPPPPPPPPPPPPPPPPPPPPEKEKKKKKKKEKEEEEEEEEVVVIIRIVVI

---M------QQQQQQQQQQFFFFFFFFFFFFFWFFFFFFGGGGGGGGGGFFFFFFFFFFPPPPPPKPPPGGGGGGGGGGMMMMMVMMMMYYYYYFFYYYLLLMLLLLVLEEEEEEEEDEVVEVVEEVVVDDDDDDDDDDPPPPPPPPPPGGGGGGGGGGAAGAGGGGAGFFFFFFFFFFKKKKKKKKKAGGAGTTTTGTSSNSNNKNSNGGNGNNNNGNHQRQRRRRQRCCCCCCCCCCEQEQEEEEQEHHHHHHHTHHCCCCCCCCCCSTTTTTTTTTKKKQKKKKQKLLLLLLLLLLVVAVVVVVVLDDDDDDDDDDAASASSSTASNNTNNNDNNN--Q-------YYYYYYYYYYLLTLTTTTLTDDDDDDDQDDEE-E----E-TL-S----S-

GEEEEEGEEERRRRRRRRRRE---------S---------S---------E---------T---------E---------Y---------KKKKKKKKKKEEEEEEEEEEAAAAAAAAAAKKKKRGKKGKSSTTSSSSSTFFFFFFFFFFIIIIIILIIINYHNHHNDHHLLLLLFLLL-NNNNNNNNN-GAATAAGAAARRRRRRRRRRKKKKKKKKKKEDAEEKEEKEIVLIIVIIVIVLAVALVVLALLLLLLLLLLEEEEEEEEEEAAAAAAAAAAIFIIIFIKFIDEDDDDDDDDLLLILLLLLLVLLLLLLLLLYYYYYYYYYYRRRRRRRRRRKKKKKKKKAKGGGGGGGGGGHHHHHHHHHHTTTTTTTTTTQQQQQQQQQQMLLLHLLLLLRRTRTRRKRTSSDSDTSSTDLLLLLLLLLLSSSSSSSSSSIIIIIKIIVITNPNNNTNNNMMMMMLMMLMTNNTNNTTNNQKQQQKKQKQPPPPPPPPPP

TGTGGGGGTTANNNNNNNNNRHRHLHHHRRFFFFYFFFFFKKKKKKKKKSYHHHHHHHHQDDDDDPDDDDKKRKKKKKKKLLLLLLLLLLQQQQQQKQQRDEEEDEEEEDFVIVVV-VIFIIIIII-IIIYYYYYY-YYYEEKEEE-EEEIIIIIIIIIITTTSTTSTTTSSSARTASSSSSPSSSSSSSAAASAAAAAARRKRRRRRRRSSASSSSSASKKKKKKKKKKIIILIIIIIIAAAEASSAAATCTTCTTTTTVILVVVVVLVSSSSQSSSSSMMMMMMMMMMSSSSSSASSTRKKKKKKKKRWWWWYWWWWW

LLLLLLLLLLQEQEQQQQQQHHHHHHHHHHQQQQQQQQQQRKKKKRKKKKPPPPPPPPPPEEEEEEEEQEGGGGGGGGGGGGGGGGGGAGMIIILMIIILGGGGSGGGTGATTTTASTTTLLLILLLLLIDDDDIDMDTMEEEETEEEEETVVVTTVTTIAAAAAAAAAAENKEEEDEEDVVLLVVTVVICMVVCCMCCMNNNNNNNNNNNNNNNNTNHTSCAAASCAACGCCCCGCCCCRQRRRRQRRQIVIIIIIIIISAAASSLSEISYSSTSYSTYLLMMLLLLLLCCCCCCCCCCAAMMAAAAAAAASAAAAAAAIIIIIIIIIISASTASASAARRRQRRAARRWTSTTTTTTTAAAAAAAAAAGGGGGGGGGG

VVVVVVVVVVSSPPSPSSSPTTTSTSTTTSFFFFFFFFFFLLLLLLLLILAPPPPPPPPPCCSSCSCSCSIIMMILIIIMAAAAEAAAASSSSSSSSSSSKKKKKDKKKKVVIVTIIVVIRRRRRSRRRSIILLLLILILDKDDDDDDDDKELKKLKKELEEEEVEEEEEAAAAAAAAAADDDDDDDDDDNNNNNNNNNNVILVVVIVIVNKNNN-NNK--S---------A---------R---------D--------LLLLLLVLLLIIIVLIVIIILLLLLLLLLLAPAAEAAATAGGGGGGGGGGWWWWWWWWWYDDDDDDDDDDAAAAAAA-MAIVVVVVV-VVFLLLLLL-LL

ECCCTDDTCCEEEDEEAKEEEEEEEEEEEEPPPPPPPPPPWWWWWWWWWWEQEEQQQQQQRRRRRRRRRREEEKEEEEEENNNNDNNDNNN----TT---L----LL---L----LL---KKKKQKKKKKGGGGGGGGGGTNNNTTTTNNIVIIVIIIVVIIIIIIIIIIYFFFYYYYFFADDDAAATDNAVAAAAAAVVPPPPPPPDPPQQQQEQQEQQVAVVVVVVVAKQKKKKKKRRQKRKKKKKKHILLLLQLLLLGGGGGGGGGGKQRRKKKKRQAGGGGGGGGGPPDDPPPPPPILVVIIIIIILMMMLMMMMMNDDDDDEDDDEKKKKKKKKKPPPPPLPPPPVVVLAVVVVVLLLLLIILLLLLLLLLLLLLSSSSSSSSSSKQQQKQQQQQIIIIIIIIIIWWWWWWWWWWYYFYYYYYYYAKKKAVVAKKVSPPVVVVSSMLMMMMMMML

NDNNNVNNNV-------L---------K---------K---------L--HYYYYYYHYYDEEDESEEDDQKKQKKKQQKIIIIIIIIIIEEEAEEPEEELLLLLLLLMLPPPPPPPPPPLLLLLLLLLLIIIIIIIVIINSNNNNSNNNATTATTKAASNNKNN-NNNNLLLLL-LLLLMVVAV-VAAVLLLLLLLLLLSSSSSTSNSSRRKRRRRRRRTTTTTNTSSNASSSSSSDSSLLLLLVLLPVFLLFLLLFFLLLLLLLLLLLEEEEEEEEEEGGGGGGGGGGFFFFCFFFFFGGGGGGGGGGTRRSKRRTSRFYFFYFFFFFTTTTTTTTTTNNNNQNNGNNFFFFFFFFFFGGGGGGGGGGKKKKKKKKKKSPPPPAPSPAKKKKKKQKKKHHHHHHHHHKNNNNNNDNNG

DNDDDNDDNDQQQQQQQQQQEEEEEEEEKEIVVLVVVIVVEEEAEQEEQEEEEEEEEEEELLLLLLLLLLVIVVVIVVIVQQQQQQHQQQAAAAVAVAASKKKRKKKKKQAAAAASAAAASSSSSSSESSLLMLLLILLLLIVLLVLVVLWWWWWWWWWWNDDDNDNDDDPPPPLPPPPPAAAAQMQAAALHLEAQLLQENNNNDNDNNNSSSSSSSSSSKRQTKSQQTTRRRRRRHRRREEEEEQEEQEFFFFIFFFFFPKPPPKPPKEQNQQMEMQELAAGAAAAGAAIVIDVVVIVESSSTASASKTCGCCCGCAGCEEEPESEEEPVVVVVVVVVVEEEEEEEEEEYYYYYFYYYYPSPSPTPPTTKQRMLQLRQQ

VVVAVVVTVAGSSSGSRSASDDDDDDEDDDKKKKKKKKKKKKKKKKQKKKQEQQQQQQHQAAAAAAAAALRRRRRRRRRRVAVAAAVAVADDDDDDDEDDQQQQQQQQQQFFFFFFFFFYRRRRRRRYRKEQEQEEEQKQVVVVVVVVIVLIIIVIIIIIKKKKKKKKKKGGGGGGGGGGDDDDDDDDDDDTDDDTNDNDVVVVLVLVLVEEEEEEEEEEFFFFFFCFCFYYFFYYYYYFEEEEETEEEETVVITVVIVIRKRKRKRKRRLLLLLLLLLLLLLLLLILLLSSSASSSSSRSSSPSSSNSDFFFFFFFFFF

IILLIIIILLYFYYYFYFFYYFYYFFFFFYEEEQEEEEETFFLLFFFFLLKKQRKKKKKQLLKKLLLIKKEEEEEEEEEESSAASSSSTAPPPPPPPPPPLFLLLLLLLLLLLLLLLLLLPPPPPPPPPPWWTTWWWWTTYYKKYYYYYKLLQRLLLLLRRRRRKRRRRRKKKKKKKKKKQQRQQQQQQRGGQQGGGGQQPPVVPVPVVVLLLLLLLLLLAAAADAAAAA--V------I--E------E--P------P--G------GDDDDDDDDDDGGKEGAGAKKFFYYFYFFYYQRSRQRQRRSFFFFFFFFFFHHYHHHNHHYKSQQKAKKQQLLLLLLLLLLAAAAAACAAARRKKRKRKKKEEEQEEEEEESTSSSSSSSSAAQAAANAAQLLIALIIIIIGGSGGGGGGA

WWWWWWWWWWRRQRRRRRRRNNSNSDSNN-PPEPPPEPP-SDDDEDDDE-TVTTTTTTTTTTTTTTTTTTWWWWWWWWWWQKKKKKKKKKAAAAAAAAAARRRRRRRRRRDDDDDDDDDGTTTTTTTTTT--N-N-N-SS--Q-E-Q-AR--T-T-T-TT--G-G-G-GG--D-D-D-DD--L-L-L-LL--N-N-D-DN--R-Q-S-QQ--Q-Q-Q-QN--T-T-T-TT--Q-Q-Q-QQ--D-D-D-DD--K-K-K-KK--I-I-I-VI--E-E-E-EE--D-D-D-EENNNNNNNNNNSSSMGSSQGGAAAAAAAASAHHHHHHHQHHLLLILLLLLLLLLLLLLLLLLLLLLLLLLLEEEEEEEEEESSSSSSSSSS

QSEEQQESQERRRRRRRKREKKKKKKKKKKTTAMMTATLTLLLLLLLLLLRRRRRRRRRRLLLLLLLLLLLLLLRNLLLLSSSSSSSSSSDDDDDDDDDDLIIIIIILIITAKAAGKAAKQQQQQQQQQQKQQQQKQLIQRRRRRRRRRRFLLLLFLLLLQSQQQQMQQQVVVIIVVVTVSDTSSSTSSSLLRLLLSLLSAAAAAAAAAADEQEEENEEEIVVIIIVIIIKKKKKKKKKKFFIFFFFFFFYHSYYYSYYYFLFFFFFFFF--------T---------E---------N---------A-EDDDAEDDADAGGGGAGGGGVQVVVVVQVVKKKKKKKEDKDDPDDDEDDEVSVVSVVSSVSPPTSSPPSPGSSCCASSCSKKKKKKKEKKSSSSSSAHSSTTTTTTTTTT

IIIIIIIIIIKKKKKKKKKKFFFFFFFFFFVEVVVVVVVVFFFFFFFFFFVVVVVAVGVIEEEDSEDEQEAEEEESESESMMMMMFMMMMK----K-K-KGGGGGGGGGGVVTVFVVVTVRKKKKRKKKRVVATTVTVVVVTTTTTTTTTLFLFLLFLLLQSRSSQSQRQGAAAAAAARARCERRRRRERNNNNNNNNNNKKKKKKKKKKRKRRRLRQRRLLILHLLLLLPVPPPPPPPPHHHRHHRHHHKKEKRKKKEKGGGGGGGGGGTTATSTTTSTEEEEEEEEEEEEEMEDEDEETSTSTTTTTTAVAFAAFAAAKKRKKKKKKKVVVIIVIVVVAPPPPGPGPGSSSSSSSSSSFFFFFFFFFFRR-RCWRSRRAGGGGAGEGASSASSSSSTSGGGGGGGGGGIIIII-I-IIHFFFF-F-FD

LLVLVLLVLVGGGGGGGGGGSSSSSSNSSSAAAAASAAAAVVVVVVVVVVLLLLLLLLLLEEEEEEEEEEYYYYYYYYYYQEEEDTEETDIVMVTMIMMMAALALLALLMLLLLLLILALQQKQKQQKQKAATATSATSEAAAAGAAAAGLLILVILVIVGGGGGGGCGGQQQQQAQQAQPPPPPPPPPPAASASASSSSIVVVVVVVVVLLLLLLILLLDDDDDDDDDDDADADDDDDDQDEEAQQQQEAACACAACACRRRRRRRRKRSSGSGGAGGGWWWWWWWWWWKKKKKPKKRKGGGGGEGGEGDDDDNEDDTDRQRRRRRRRR-------G---------G---------A---------K---------C---------T---------E--GGGGGGGGGGDDDDDDDNEDASLSVVVVVVLIIIIVVIIINNNNEENNENQSQSQQQQQQRRRRRRRQRR----K----KVIMIAMMMMAVVVVVAIVVV

DDDDDDDDDDKKKKKKKKKKEEEEEEEAEEAEVIVLLVVVIIIIVIIIITWIIMIIIIVIEEEEEDDEEEDDDDDDDDDDVTVVRLVVVVNNNNNNNNNNSPSNPSSPPSDEEEEQESEESGSQGGAGGAPPPPPPPPPPEEEEEEEEEEIIIIVIIIITEEEEEEEEEENNNNNHHNNNIIIIIIIIIIKLKKLKKLLKLLLLLLLLLLRKRKKKKKKKLILLLLLLILAAAAAAEAAATLTTLTTLLTMWWMWRRWWRFFFFFFFFFFLNLVDNNDNNFFFFFFFFFFPPPPPPPPPPFFFFFFFFFFLLILLLLLMLPPPPPPPPPPRRRRRRRKRRGAGGSNGSGGEEEEEKEEEEANAADNNDNNVEAAAAAAAAQEEQEEEEQEHKHHHHHHHHKKKKKKKKKK

GGGGGGGGGGAAAAAAAAAASSSSSSSSSTYYYYYYNYYYCSCSS-CSSCLLLLL-LLLLEQQQQ-QQRETVTVL-VILTDDDDD-DDDDVVLLV-VVVVAAAAL-AAAEGGGGG-GGGGGGGGG-GGGGVVVIV-LVVIGGGGG-GGGGEEEQE-EEEEIIIII-IIIIKRRRR-RRRRRAAAA-AAEAYYYYY-YYYYASAAA-AAAAPPPPP-PPPPNKNKK-KKKNEEEEE-EEEESSSSS-SSSSAAAAS-ATAAKSKST-ASSKSSSSS-SSSPIIIII-IICIKIKKK-KKKKTVVLV-VVVVLLLLLLLTLLLMMMIMMILMWWWWWWWWWWLLLLLLLLLLA-AAAAPAASD-DDEDDEDDV-VLLVLLLVV-IVIVIIIAR-RRRRRRRRVVVVLVVVVV

SSSDSSSDSSRQQQQRQQQQLLLFFLLFLLIIVVIIVIIIEEEEEEEEEE--Q---Q-----I---I-----Q---Q-----I---V-----P---P-----V---V-----G---G-----T---T-----P---A-----R---R-----S---S-----R---R-----K---N-----D---D-----R---R-----G---G-----D---D-----S---S-----L---L-----S---S-----V---V-----I---L-----M---M-----F---F-----H---H-----N---N-----L---M---KKKKKKGKKK---------E---------R---------M---------L---------K---------VQQTQQQTQTTYYYFYYYYYYANNNNANNNNEEEEEEEEEEKKKEEKKEKKQQQQQEQQSENNNNNNNNGGRRRQRRRQRQEEEEEEEEVVPPPPPPPPPPHHHHHHHHEHKRRKRKRKRRRRRRRRRRRRPPPPPPPPPPRRRRRRRRQQPPPPPPPPPPIII--II-IIAAP--AP-AASST--TT-TTMMMMMMIMMMDEEEEDEEEELMLLLLLLMLSSSSSSSSSSGGGGGGGGGGVVVIVVVIVVLLLIILILLIRKKKKRKKKKKQKEKKKKAATTTTTTTTTTAAPAAAPAAAVVVVVVVVII----E-----LLLLLLLLLLLLLLILLLLLNNNNNNNNNNDEEEEEEEEEIVIIIIVIII

FFFFFFFFFFLLLILLLLLLSSSSSSSSSSTTTTTATTTTTASDASAAASPPAPPPPPPAGGGGGGGGGGKKKKKKKKKKIIIIIIIIIVAAVAAASAAVGEGGGGGGGGLILFLLLLLLGGGGGGGASGGGGGGGGGGGMMMMMMMMMMIVVVVQVVVVAAAAKAAAAALVVVVLVNVVLLLLLLLLLLFFYFYFYYYYSSSSASSSASFFFFLFFFLFKKRKRKRRRRIIIYIIIIVILLLLLLLLLLSSASSSSSSAMMMMMMMMMMDESEDDDDDDFFFFFFFFFF--V-M-IIMV-R-R-------V-V-------R-R-------T-T-------I-I-------L-L-------R-R------PPPPPPPPPPFFFFFFFFFFKKKKEKKKEKEESESETTSSLVIVIVFFIIIVVVVVVVVVFFFFFFFFFFVVVVVVVVVVRRLNGRRRGLSSASSSSSSAHHYHHHSHHIEEEEEEEQEENNNNNNNNNN

PPPPPPPPPPIIIIIIIIILTSTTTTTTTAVVVVVVVIIITTTTTTTTTRWWWQQWNWWWAAAAAAAAAALLLLLLLLLLWYYYYWSWYWDEDEDENEEECCCCTCCCCCCSHSSCSCSCMLMMMMMMMMEEEEEEEEEEAGGGGGGGGGSTTTSVSVTLYYYYYYYFYFPPPPPPPSPPEEEEEEEEEEEEEEEEEEDEPPPPPPPPPPVIIIIIIIIIRRRRRRRRRRDDDDDDDDDDVIIVVIIIIIFFFFFFFFFFLLLLLILLLLKKKKKKGKKKKKKKKKKKKKAAAALVAVALYYYYYYYYYYNPNPPPPPPPVVVVVVVVVVYIIIIIVIILNNNNNNNNNNIVIIIVIIIVAAAAASAAAAQQQEEQEQQQGGGGGGGGGG

ICVVCVILIINN-NN-DNNNVV-VV-VVFVDA-AA-DEAEYY-YY-YYYYSS-SS-SSANTQ-QQ-TKQKLL-LL-LLLRPP-PP-PPAPST-VT-ATTTPP-PP-PPPPII-VV-IIIIRR-YR-RKYKYY-YY-YYFYYY-YY-YYYYML-LL-LLLLGG-GG-EGGGKK-KK-KKKKQQ-QQ-QQQQSS-SG-ASSSMM-MM-MMMLEE-AE-NEEERR-RR-RRRRSA-AA-SSASGG-GG-GGGGFL-LL-FLFLSP-PP-SSPSLL-LL-LLMITT-TT-TTTTHENHENHHHHVVVVVVVVVVESEESEEEEEGGGGGGGGGGVLLLLLVVLC------R---------I---------T---RRKKRKRRKRIILLILILLLDEDEEDDDDDGNDNTDGGDGEEEEEEEEEE

PPPPPPPPPPNNSSNNSNNNQKGGKKKKAKSSSSSSSSSSVAIIVIIIVLDDDDDDDDNDYYYYYYYYYYLILVLLLLLLFFFFFFFFFFEEEEEEEEEEPPPPPPPPPPILLLLLLLLLDDTTDDDDDDNNQQNNHNNNCCLLCCCCCCEELLELLEEESSEESEETSSSSSSSSSSSSDEDDDDDDEDLLLLLLLLLLNDDDDDDDDDRRRRRRRRRREEEEEEEEEEVVVVVHVVIVTTFFTFFFTFTTTTTTTTMTVLLLLLFLLLPPTPPPPPPPF---------H---------M---------G---------V---------I---------S---------AAAAAVVAAAEQHHQQQQQQNTSSNSDSTSIITTILLIIL

RRRRRRRRKRRRRRNRNNRRGGGGGGGGGGMMMMMMMMMMQLLMMMMMMMIIVIVIVVIIDDDDDDDDDDIIIIVIIIIIHHHRHHHHHHEQQQQQQQQQNNNNNNNNNNSSSSSASSSAKKKKKKKKKKVVVVVVVVVVNEEEEEEEEEQQQQQQQQQQFYYYRQYYYQSDSSSKSSKKGGGGGGGGGGKKKKKKKKKKVVIKVVVVVVSSSSSSASSSSAAAAAAAAATTTTVTVVTTQQQQKLKKQQDDDDDDDEDSTTTVVVIVVVDDDDDDDHDDFFFFFFFFFFDDDDDDDDDDAAAAAAAAAARRRRKRKKRRDDDEQELEEEYVVYYYYYYYGAGGGGGGGGGGGGFGFFGGRRRRRRRRRREEEEEEEEEEVVVVVVVVVV

LLLLLLLLLVNNNNNNNNNNVACVVVCCAVRRRRRRKNRRSSSSSSSSSSIIIIIIIIIINNNKKNNNNNGGSGGGGGGGNNNNNNNNSYGGGGGGGGGGQQQQ-QQQQQVIII-IIIIIFFFF-FFFFFVVIV-IVVVIQKEK-EEEQKNNGQ-NNNNNPPPP-PPPPPFFMF-FFFFFCCAC-CAACCKKYK-YYYYYEEEE-EEEEEFFFF-FFFYFEEEE-EEEEEIIVI-VVVLV-----K---------D---------C----FFFF-FFFFFAASA-SSSASILII-IVIIISSDS-DDDDDRRRR-RRRRRAAGA-AGGAAGAAA-AAAAASS-S-SS-SSFF-F-LL-FLTT-T-TR-TTQQ-Q-ST-QSEQ-E-KK-KKSS-S-SS-SSRK-R-RR-RQVVVVVVAVIV

AAAAAAAAAA----M-----KGGGGKRGGKWLLLLLLLLWKKPPKGKKPKVVVVVVIVVVLLLLSLLSLLLILLILLILLKKKKKKKKKKLLLLLLLLLLNNNNSNNRNNDDDDNDDNDDGGGGGGGGGGLLLLLLLLLMASSSNAASSALILLILLILLEEEEEDEEEELLLLLLLILLSSSSSSSSKSYGGGGGGGGYEEEEEEEEEEKQQQQEQQQQII-MVIIIMIVSTTSTTSTVLLTLLLLLTFEEEEDEEDEEVIIIIIIIIVHYSHHHHHSHIILLIIIILILLLLLLLLLLIITIVIIITLQLLLLPPLLPLLLLLLLLLLRRRRRRRRRR

RKRRKRRKKK--------W-FFFFFFFFFFHHHHHHHHHHKEKKEKKEEESSAAQSAQSSEEKKEKKEEKGQAAQAAQQQVVIIVIIVVIAAAAAAAAAALILLLLLLLLIVFIIIIIIIIVIIVIIVVVSSAASSASSSDDDDDDDEDDIIVIIIVIIFTTTTNTTNTT--P---------G-------AGAAGAAGSSGGGGGGGGGGICVVVVVVIIWWWWWWWWWWEEEEEEEEKERKRRKRRKKKVVVAVVAVCVNNNNNNNNNHLLLLLLLLLLAAAAAAATAARKKRKRRKRSGGGGGGGGGGEEEEEDEEEESSPPSSPSSS-P--------FFFFFFFFFFNNNNNNNNNNEEEEEEEDEEETESAESAAAQAQQEQEREEILIMLIMLMFLLLLLLLLLLACAACAACLCDDDDDDDDDDDDDDDDDDDDKKKKKQKKKKRQRLKRLKRRTTTTTTLTTT

TTPTTQPTPLEEDEEEDEEEKKEKKKEKEKQQQQVQQQQQLLLLLLLLLLVTAAAVAAAVKTKTKKKEKKLLVLLLILILAVVVVSVVISTTTTTTTTTTPKKKRKKQKKLLFLLLLLLLTTLTTTTTTT--------I-GGGGGGGGGGEEEEEEEEEEMMMMMMIMMMYHQHHYQHQYNNNNGNNNNNSSSSSSSSSSIVIVIIIILI-----A---AAVAAAAAAVATATATTTTTTTTTTTTTTTTYIYYYYYYYYVVVVVSVVVTNGGDGNGGGNVIMLIVMIVVNENNNDNNNNDDDDDDDDDDKKE-KREKKKDDE-DDDDDDLLL-LLLLQL-----V---------T---------A---------M---------Q---------L---------T---------N---------Q---------D---------L---------S---------T---------K---------I---------P---------D---------D---------L---------R---------R----EEE-EEEEEE