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Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study.

A re-increasing trend of thyroid cancer since 2015 has been observed despite a similar examination rate, and the incidence of thyroid cancer among young adults continues to rise.

Pushed to the edge: Spatial sorting can slow down invasions.

Our ability to understand population spread dynamics is complicated by rapid evolution, which renders simple ecological models insufficient. If dispersal ability evolves, more highly dispersive individuals may arrive at the population edge than less dispersive individuals (spatial sorting), accelerating spread. If individuals at the low-density population edge benefit (escape competition), high dispersers have a selective advantage (spatial selection). These two processes are often described as forming a positive feedback loop; they reinforce each other, leading to faster spread. Although spatial sorting is close to universal, this form of spatial selection is not: low densities can be detrimental for organisms with Allee effects. Here, we present two conceptual models to explore the feedback loops that form between spatial sorting and spatial selection. We show that the presence of an Allee effect can reverse the positive feedback loop between spatial sorting and spatial selection, creating a negative feedback loop that slows population spread.

All-in-one diagnostic and therapeutic precision thoracic surgery using a hybrid operating theatre: the triple-marking technique.

The minimally invasive management of sub-centimetric and often sub-solid lung lesions is quite challenging for thoracic surgeons. As a matter of fact, thoracoscopic wedge resection can often require conversion to thoracotomy when pulmonary lesions cannot be visually identified. Hybrid operating rooms (ORs) can serve as a helpful tool in a multidisciplinary setting, providing real-time lesion imaging and targeting, allowing preoperative or intraoperative percutaneous placement of different lesions targeting techniques to help locate non-palpable lung nodules during video-assisted thoracic surgery. The aim of the study is to assess whether the lung nodule marking using methylene blue, indocyanine green, and gold seeds - the "triple-marking technique" - in the hybrid OR is effective in helping locate non-visible or palpable nodules.

Foveal to peripheral extrapolation of facial emotion.

Peripheral vision is characterized by poor resolution. Recent evidence from brightness perception suggests that missing information is filled out with information at fixation. Here we show a novel filling-out mechanism: when participants are presented with a crowd of faces, the perceived emotion of faces in peripheral vision is biased towards the emotion of the face at fixation. This mechanism is particularly important in social situations where people often need to perceive the overall mood of a crowd. Some faces in the crowd are more likely to catch people's attention and be looked at directly, while others are only seen peripherally. Our findings suggest that the perceived emotion of these peripheral faces, and the overall perceived mood of the crowd, is biased by the emotions of the faces that people look at directly.

Improved 2-Year Freedom from Arthroplasty in Patients with High-Risk SIFK Scores and Medial Knee Osteoarthritis Treated with an Implantable Shock Absorber versus Non-Operative Care.

Subchondral insufficiency fracture of the knee (SIFK) is associated with high rates of osteoarthritis (OA) and arthroplasty. The implantable shock absorber (ISA) is an extra-capsular implant that unloads the medial knee compartment. This study compared the 2-year freedom from arthroplasty rates in subjects with medial knee OA and SIFK when treated with an ISA versus a matched cohort of patients treated non-surgically.

Photoionic Effect Imposed by Photoresponsive Local Field in a Tellurate Glass with Lanthanide Ions and Ag Nanoparticles.

Understanding the photoionic mechanism in optoelectronic materials offers significant potential for various applications in the fields of laser, data/energy storage, signal processing, and ionic batteries. However, the research on such light-matter interaction using photons of sub-bandgap energy is scarce, especially for those transparent materials with photoactive centers that would generate a local field upon photoillumination. This research investigates the photoionic effect in Yb

Cytotoxicity sesquiterpenoids from the leaves of

Four new sesquiterpenoids, dstramonins A-D (

Sulfur-Containing Radical Anions Formed by Photolysis of Thiosulfate: Quantum-Chemical Analysis.

The photochemistry of sodium thiosulfate (S

Biomechanics of calcaneus impacted by talus: a dynamic finite element analysis.

This paper aimed to investigate the biomechanical changes during the talus impact with the calcaneus at varying velocities. Various three-dimensional reconstruction software was utilized to construct a finite element model that consisted of the talus, calcaneus, and ligaments. The explicit dynamics method was used to explore the process of the talus impacting on the calcaneus. The velocity of impact was altered from 5 m/s to 10 m/s with a 1 m/s interval. Stress readings were collected from the posterior, intermediate, and anterior subtalar articular (PSA, ISA, ASA), calcaneocubic articular (CA), Gissane Angle (GA), calcaneal base (BC), medial wall (MW), and lateral wall (LW) of the calcaneus. The changes in the amount and distribution of stress in the different regions of the calcaneus that varied with velocity were analysed. The model was validated through comparison with findings from the existing literature. During the process of impact between the talus and calcaneus, the stress in the PSA reached its peak first. Notably, stress was concentrated mainly in the PSA, ASA, MW, and LW of the calcaneus. At varying impact velocities of the talus, the mean maximum stress of the PSA, LW, CA, BA, and MW exhibited statistically significant differences (P values were 0.024, 0.004, <0.001, <0.001, and 0.001, respectively). However, the mean maximum stress of the ISA, ASA, and GA was not statistically significant (P values were 0.289, 0.213, and 0.087, respectively). In comparison with the velocity at 5 m/s, the mean maximum stress increases in each region of the calcaneus at a velocity of 10 m/s were as follows: PSA 73.81%, ISA 7.11%, ASA 63.57%, GA 89.10%, LW 140.16%, CA 140.58%, BC 137.67%, MW 135.99%. The regions of stress concentration were altered, and the magnitude and sequence of peak stress in the calcaneus also varied according to the velocity of the talus during impact. In conclusion, the velocity of the talus during impact had a significant influence on the magnitude and distribution of stress within the calcaneus, which was a crucial factor in the development of calcaneal fractures. It was possible that the magnitude and sequence of stress peaks played a vital role in determining the emergence of fracture patterns.

Conservative Functional Treatment of Acute Fibular Ligament Rupture of the Ankle.

Acute rupture of the fibular ligament complex is one of the commonest injuries in sports. Prospective randomized trials in the 1980s led to a paradigm shift from primary surgical repair to conservative functional treatment.

Genetic insights into the risk of metabolic syndrome and its components on stroke and its subtypes: Bidirectional Mendelian randomization.

The role of metabolic syndrome (MetS) on stroke has been explored only in many observational studies. We conducted Mendelian randomization (MR) to clarify whether or not the genetically predicted MetS and its components are causally associated with stroke and its subtypes. Genetic instruments of MetS and its components and outcome data sets for stroke and its subtypes came from the gene-wide association study in the UK Biobank and MEGASTROKE consortium, respectively. Inverse variance weighting was utilized as the main method. Genetically predicted MetS, waist circumference (WC), and hypertension increase the risk of stroke. WC and hypertension are related to increased risk of ischemic stroke. MetS, WC, hypertension, and triglycerides (TG) are causally associated with the increasing of large artery stroke. Hypertension increased the risk of cardioembolic stroke. Hypertension and TG lead to 77.43- and 1.19-fold increases, respectively, in small vessel stroke (SVS) risk. The protective role of high-density lipoprotein cholesterol on SVS is identified. Results of the reverse MR analyses show that stroke is related to hypertension risk. From the genetical variants perspective, our study provides novel evidence that early management of MetS and its components are effective strategies to decrease the risk of stroke and its subtypes.

An International, Multicenter Evaluation of Comprehensive Medication Management by Pharmacists in ICU Recovery Centers.

Post-intensive care syndrome (PICS) is defined as a new or worsening impairment in physical, cognitive, or mental health following critical illness. Intensive care unit recovery centers (ICU-RC) are one means to treat patients who have PICS. The purpose of this study is to describe the role of pharmacists in ICU-RCs.

Latino Migrant Farmworker Youths' Perceptions of Access to Care in the Southeast: A Qualitative Approach.

This study explored Latino Migrant Farmworker (LMFW) youths' perceptions regarding access to health care in the United States (U.S.). Twenty semi-structured audio-voice recorded interviews were conducted with LMFW youths (aged 15-20 years old) in Georgia and Florida. Thematic analysis was used to explore whether, and how, LMFW youths would seek health care in the U.S. as well as their personal views toward health care. Five distinct perceptions regarding accessing health care were delineated: (1) cultural-related views and attitudes toward health care, (2) transportation dependency, (3) English language as a barrier for communication, (4) lack of knowledge of available resources, and (5) embracing the obligation, and the necessity, of work. Some of LMFW youths' perceptions of seeking access to health care in the U.S. point to barriers related to social determinants of health. These barriers suggest the need for significant reform within the U.S. health care system to include farmworker youths' health needs and to promote cultural responsiveness among clinicians and rural health providers to better serve this vulnerable population.

Coronary microvascular dysfunction due to Chagas disease: where are we now?

Myocardial ischemia is common in patients with chronic Chagas cardiomyopathy (CCC), but only recently clinical and experimental studies highlighted the involvement of this abnormality as contributing to the progression of myocardial damage.