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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | WelChol decreased the Cmax and AUC of sustained-release verapamil (Calan SR ) by approximately 31% and 11%, respectively. | <WelChol, mechanism, verapamil>, <WelChol, mechanism, Calan SR> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | DIAMOX modifies phenytoin metabolism with increased serum levels of phenytoin. | <DIAMOX, mechanism, phenytoin>, <DIAMOX, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. | <DIAMOX, mechanism, primidone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone. | <DIAMOX, advise, primidone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Acetazolamide may increase the effects of other folic acid antagonists. | <Acetazolamide, effect, folic acid antagonists> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect. | <Acetazolamide, mechanism, amphetamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Acetazolamide reduces urinary excretion of quinidine and may enhance its effect. | <Acetazolamide, mechanism, quinidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Acetazolamide may prevent the urinary antiseptic effect of methenamine. | <Acetazolamide, effect, methenamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Acetazolamide increases lithium excretion and the lithium may be decreased. | <Acetazolamide, mechanism, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Acetazolamide and sodium bicarbonate used concurrently increases the risk of renal calculus formation. | <Acetazolamide, effect, sodium bicarbonate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Acetazolamide may elevate cyclosporine levels. | <Acetazolamide, mechanism, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Since PLETAL is extensively metabolized by cytochrome P-450 isoenzymes, caution should be exercised when PLETAL is coadministered with inhibitors of C.P.A. such as ketoconazole and erythromycin or inhibitors of CYP2C19 such as omeprazole. | <PLETAL, advise, ketoconazole>, <PLETAL, advise, erythromycin>, <PLETAL, advise, omeprazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Pharmacokinetic studies have demonstrated that omeprazole and erythromycin significantly increased the systemic exposure of cilostazol and/or its major metabolites. | <omeprazole, mechanism, cilostazol>, <erythromycin, mechanism, cilostazol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Population pharmacokinetic studies showed higher concentrations of cilostazol among patients concurrently treated with diltiazem, an inhibitor of C.P.A.. | <cilostazol, mechanism, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Animal experience indicates that clorazepate dipotassium prolongs the sleeping time after hexobarbital or after ethyl alcohol, increases the inhibitory effects of chlorpromazine, but does not exhibit monoamine oxidase inhibition. | <clorazepate dipotassium, effect, hexobarbital>, <clorazepate dipotassium, effect, ethyl alcohol>, <clorazepate dipotassium, effect, chlorpromazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The actions of the benzodiazepines may be potentiated by barbiturates, narcotics, phenothiazines, monoamine oxidase inhibitors or other antidepressants. | <benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, narcotics>, <benzodiazepines, effect, phenothiazines>, <benzodiazepines, effect, monoamine oxidase inhibitors>, <benzodiazepines, effect, antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phospholine Iodide potentiates other cholinesterase inhibitors such as succinylcholine or organophosphate and carbamate insecticides. | <Phospholine Iodide, effect, cholinesterase inhibitors>, <Phospholine Iodide, effect, succinylcholine>, <Phospholine Iodide, effect, organophosphate insecticide>, <Phospholine Iodide, effect, carbamate insecticide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibiotics or potent diuretics such as furosemide. | <cephalosporins, effect, aminoglycoside antibiotics>, <cephalosporins, effect, diuretics>, <cephalosporins, effect, furosemide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chloramphenicol has been shown to be antagonistic to beta-lactam antibiotics, including ceftazidime, based on in vitro studies and time kill curves with enteric gram-negative bacilli. | <Chloramphenicol, effect, beta-lactam antibiotics>, <Chloramphenicol, effect, ceftazidime> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anakinra: Concurrent administration of anakinra (an interleukin-1 antagonist) and another TNF-blocking agent has been associated with an increased risk of serious infections, an increased risk of neutropenia and no additional benefit compared to these medicinal products alone. | <anakinra, effect, TNF-blocking agent>, <interleukin-1 antagonist, effect, TNF-blocking agent> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore the, combination of anakinra with other TNF-blocking agents, including HUMIRA, may also result i n similar toxicities. | <anakinra, effect, TNF-blocking agents>, <anakinra, effect, HUMIRA> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concurrent use of two or more drugs with anticholinergic activity--such as an antipsychotic drug (eg, chlorpromazine), an antiparkinsonian drug (eg, trihexyphenidyl), and/or a tricyclic antidepressant (eg, amitriptyline)--commonly results in excessive anticholinergic effects, including dry mouth and associated dental complications, blurred vision, and, in patients exposed to high temperature and humidity, hyperpyrexia. | <antipsychotic drug, effect, antiparkinsonian drug>, <antipsychotic drug, effect, trihexyphenidyl>, <antipsychotic drug, effect, tricyclic antidepressant>, <antipsychotic drug, effect, amitriptyline>, <chlorpromazine, effect, antiparkinsonian drug>, <chlorpromazine, effect, trihexyphenidyl>, <chlorpromazine, effect, tricyclic antidepressant>, <chlorpromazine, effect, amitriptyline>, <antiparkinsonian drug, effect, tricyclic antidepressant>, <antiparkinsonian drug, effect, amitriptyline>, <trihexyphenidyl, effect, tricyclic antidepressant>, <trihexyphenidyl, effect, amitriptyline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Isoflurane, enflurane, and halothane decrease the ED50 of NUROMAX by 30% to 45%. | <Isoflurane, mechanism, NUROMAX>, <enflurane, mechanism, NUROMAX>, <halothane, mechanism, NUROMAX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Other drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as NUROMAX include certain antibiotics (e. g., aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, and sodium colistimethate), magnesium salts, lithium, local anesthetics, procainamide, and quinidine. | <NUROMAX, effect, antibiotics>, <NUROMAX, effect, aminoglycosides>, <NUROMAX, effect, tetracyclines>, <NUROMAX, effect, bacitracin>, <NUROMAX, effect, polymyxins>, <NUROMAX, effect, lincomycin>, <NUROMAX, effect, clindamycin>, <NUROMAX, effect, colistin>, <NUROMAX, effect, sodium colistimethate>, <NUROMAX, effect, magnesium>, <NUROMAX, effect, lithium>, <NUROMAX, effect, anesthetics>, <NUROMAX, effect, procainamide>, <NUROMAX, effect, quinidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | As with some other nondepolarizing neuromuscular blocking agents, the time of onset of neuromuscular block induced by NUROMAX is lengthened and the duration of block is shortened in patients receiving phenytoin or carbamazepine. | <nondepolarizing neuromuscular blocking agents, effect, phenytoin>, <nondepolarizing neuromuscular blocking agents, effect, carbamazepine>, <NUROMAX, effect, phenytoin>, <NUROMAX, effect, carbamazepine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Plasma levels of anticonvulsant agents may become subtherapeutic during cisplatin therapy. | <anticonvulsant agents, mechanism, cisplatin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | poor metabolizers of debrisoquin: Interactions of carvedilol with strong inhibitors of CYP2D6 (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol . | <quinidine, effect, carvedilol>, <fluoxetine, effect, carvedilol>, <paroxetine, effect, carvedilol>, <propafenone, effect, carvedilol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Catecholamine-depleting Agents: Patients taking both agents with b-blocking properties and a drug that can deplete catecholamines (e.g., reserpine and monoamine oxidase inhibitors) should be observed closely for signs of hypotension and/or severe bradycardia. | <agents with b-blocking properties, effect, reserpine>, <agents with b-blocking properties, effect, monoamine oxidase inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Clonidine: Concomitant administration of clonidine with agents with b-blocking properties may potentiate blood-pressure- and heart-rate-lowering effects. | <clonidine, effect, agents with b-blocking properties> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When concomitant treatment with agents with b-blocking properties and clonidine is to be terminated, the b-blocking agent should be discontinued first. | <agents with b-blocking properties, advise, clonidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cyclosporine: Modest increases in mean trough cyclosporine concentrations were observed following initiation of carvedilol treatment in 21 renal transplant patients suffering from chronic vascular rejection. | <cyclosporine, mechanism, carvedilol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Due to wide interindividual variability in the dose adjustment required, it is recommended that cyclosporine concentrations be monitored closely after initiation of carvedilol therapy and that the dose of cyclosporine be adjusted as appropriate. | <cyclosporine, advise, carvedilol>, <carvedilol, advise, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digoxin: Digoxin concentrations are increased by about 15% when digoxin and carvedilol are administered concomitantly. | <digoxin, mechanism, carvedilol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Both digoxin and COREG slow AV conduction. | <digoxin, effect, COREG> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, increased monitoring of digoxin is recommended when initiating, adjusting, or discontinuing COREG. | <digoxin, advise, COREG> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Inducers and Inhibitors of Hepatic Metabolism: Rifampin reduced plasma concentrations of carvedilol by about 70%. | <Rifampin, mechanism, carvedilol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Calcium Channel Blockers: Isolated cases of conduction disturbance (rarely with hemodynamic compromise) have been observed when COREG is co-administered with diltiazem. | <COREG, effect, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | As with other agents with b-blocking properties, if COREG is to be administered orally with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored. | <COREG, advise, verapamil>, <COREG, advise, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Insulin or Oral Hypoglycemics: Agents with b-blocking properties may enhance the blood-sugar-reducing effect of insulin and oral hypoglycemics. | <Agents with b-blocking properties, effect, insulin>, <Agents with b-blocking properties, effect, hypoglycemics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Elevated plasma levels of theophylline have been reported with concomitant quinolone use. | <theophylline, mechanism, quinolone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | There have been reports of theophylline-related side effects in patients on concomitant therapy with norfloxacin and theophylline. | <norfloxacin, effect, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with norfloxacin. | <cyclosporine, mechanism, norfloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Quinolones, including norfloxacin, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or similar agents. | <Quinolones, effect, anticoagulants>, <Quinolones, effect, warfarin>, <norfloxacin, effect, anticoagulants>, <norfloxacin, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant administration of quinolones including norfloxacin with glyburide (a sulfonylurea agent) has, on rare occasions, resulted in severe hypoglycemia. | <quinolones, effect, glyburide>, <norfloxacin, effect, glyburide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Diminished urinary excretion of norfloxacin has been reported during the concomitant administration of probenecid and norfloxacin. | <probenecid, mechanism, norfloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant use of nitrofurantoin is not recommended since nitrofurantoin may antagonize the antibacterial effect of Norfloxacin in the urinary tract. | <nitrofurantoin, effect, Norfloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Multivitamins, or other products containing iron or zinc, antacids or sucralfate should not be administered concomitantly with, or within 2 hours of, the administration of norfloxacin, because they may interfere with absorption resulting in lower serum and urine levels of norfloxacin. | <Multivitamins, advise, norfloxacin>, <iron, advise, norfloxacin>, <zinc, advise, norfloxacin>, <antacids, advise, norfloxacin>, <sucralfate, advise, norfloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Videx (Didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be administered concomitantly with, or within 2 hours of, the administration of norfloxacin, because these products may interfere with absorption resulting in lower serum and urine levels of norfloxacin. | <Videx, advise, norfloxacin>, <Didanosine, advise, norfloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Some quinolones have also been shown to interfere with the metabolism of caffeine. | <quinolones, mechanism, caffeine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Interactions attributed to the combined use of baclofen injection and epidural morphine include hypotension and dyspnea. | <baclofen, effect, morphine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended that the combination of intravenous dantrolene sodium and calcium channel blockers, such as verapamil, not be used together during the management of malignant hyperthermia crisis until the relevance of these findings to humans is established. | <dantrolene sodium, advise, calcium channel blockers>, <dantrolene sodium, advise, verapamil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Administration of dantrolene may potentiate vecuronium-induced neuromuscular block. | <dantrolene, effect, vecuronium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The vasodilating effects of nitroglycerin may be additive with those of other vasodilators. | <nitroglycerin, effect, vasodilators> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. | <calcium channel blockers, effect, nitrates> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In patients receiving nonselective monoamine oxidase inhibitors (MAOIs) (e.g., selegiline hydrochloride) in combination with serotoninergic agents (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine), there have been reports of serious, sometimes fatal, reactions. | <monoamine oxidase inhibitors, effect, serotoninergic agents>, <monoamine oxidase inhibitors, effect, fluoxetine>, <monoamine oxidase inhibitors, effect, fluvoxamine>, <monoamine oxidase inhibitors, effect, paroxetine>, <monoamine oxidase inhibitors, effect, sertraline>, <monoamine oxidase inhibitors, effect, venlafaxine>, <MAOIs, effect, serotoninergic agents>, <MAOIs, effect, fluoxetine>, <MAOIs, effect, fluvoxamine>, <MAOIs, effect, paroxetine>, <MAOIs, effect, sertraline>, <MAOIs, effect, venlafaxine>, <selegiline hydrochloride, effect, serotoninergic agents>, <selegiline hydrochloride, effect, fluoxetine>, <selegiline hydrochloride, effect, fluvoxamine>, <selegiline hydrochloride, effect, paroxetine>, <selegiline hydrochloride, effect, sertraline>, <selegiline hydrochloride, effect, venlafaxine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because dexfenfluramine is a serotonin releaser and reuptake inhibitor, dexfenfluramine should not be used concomitantly with a MAO inhibitor. | <dexfenfluramine, advise, MAO inhibitor> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | At least 14 days should elapse between discontinuation of a MAO inhibitor and initiation of treatment with dexfenfluramine. | <MAO inhibitor, advise, dexfenfluramine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | At least 3 weeks should elapse between discontinuation of dexfenfluramine and initiation of treatment with a MAO inhibitor. | <dexfenfluramine, advise, MAO inhibitor> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A rare, but serious, constellation of symptoms, termed serotonin syndrome, has been reported with the concomitant use of selective serotonin reuptake inhibitors (SSRIs) and agents for migraine therapy, such as Imitrex (sumatriptan succinate) and dihydroergotamine. | <selective serotonin reuptake inhibitors, effect, Imitrex>, <selective serotonin reuptake inhibitors, effect, sumatriptan succinate>, <selective serotonin reuptake inhibitors, effect, dihydroergotamine>, <SSRIs, effect, Imitrex>, <SSRIs, effect, sumatriptan succinate>, <SSRIs, effect, dihydroergotamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Dexfenfluramine should not be administered with other serotoninergic agents. | <Dexfenfluramine, advise, serotoninergic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Itraconazole decreases busulfan clearance by up to 25%, and may produce AUCs 1500 M min in some patients. | <Itraconazole, mechanism, busulfan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenytoin increases the clearance of busulfan by 15% or more, possibly due to the induction of glutathione-S-transferase. | <Phenytoin, mechanism, busulfan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Since the pharmacokinetics of BUSULFEX were studied in patients treated with phenytoin, the clearance of BUSULFEX at the recommended dose may be lower and exposure (AUC) higher in patients not treated with phenytoin. | <BUSULFEX, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because busulfan is eliminated from the body via conjugation with glutathione, use of acetaminophen prior to ( 72 hours) or concurrent with BUSULFEX may result in reduced busulfan clearance based upon the known property of acetaminophen to decrease glutathione levels in the blood and tissues. | <acetaminophen, mechanism, BUSULFEX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Trecator has been found to temporarily raise serum concentrations of isoniazid. | <Trecator, mechanism, isoniazid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Trecator may potentiate the adverse effects of other antituberculous drugs administered concomitantly. | <Trecator, effect, antituberculous drugs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In particular, convulsions have been reported when ethionamide is administered with cycloserine and special care should be taken when the treatment regimen includes both of these drugs. | <ethionamide, effect, cycloserine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Danazol: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol particularly with higher doses of lovastatin (see WARNINGS, Myopathy/Rhabdomyolysis). | <danazol, effect, lovastatin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Amiodarone or Verapamil: The risk of myopathy/rhabdomyolysis is increased when either amiodarone or verapamil is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS, Myopathy/Rhabdomyolysis). | <amiodarone, effect, HMG-CoA reductase inhibitor class>, <verapamil, effect, HMG-CoA reductase inhibitor class> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, another HMG-CoA reductase inhibitor has been found to produce a less than two-second increase in prothrombin time in healthy volunteers receiving low doses of warfarin. | <HMG-CoA reductase inhibitor, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Also, bleeding and/or increased prothrombin time have been reported in a few patients taking coumarin anticoagulants concomitantly with lovastatin. | <coumarin anticoagulant, effect, lovastatin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended that in patients taking anticoagulants, prothrombin time be determined before starting lovastatin and frequently enough during early therapy to insure that no significant alteration of prothrombin time occurs. | <anticoagulants, advise, lovastatin> |