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+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+We have shown that non-Alp GBS differ from Alp GBS in the region surrounding the insertion site of Alp genes of Alp GBS as well as in their content of other surface proteins and that PCR for the upstream flanking region of the Alp gene may be useful for differentiation between Alp and non-Alp GBS .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+DESIGN AND METHODS : In this genotype-phenotype analysis we screened the coding sequence and intron-exon boundaries of RPS14 , RPS16 , RPS24 , RPL5 , RPL11 , and RPL35A in 92 Italian patients with Diamond-Blackfan_anemia who were negative for RPS19 mutations .
+A double-blind , randomized , prospective , parallel-group study was conducted to evaluate the efficacy and safety of MTA in the treatment of asthmatic_crisis in children 2 to 6 years of age .
+Autosomal dominant PTHS is caused by mutations in the transcription_factor_4 -LRB- TCF4 -RRB- gene , whereas NRXN1 and CNTNAP2 mutations are associated with autosomal recessive PTHS .
+A randomized , double-blind , placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic_stress_disorder .
+We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+A randomized , double-blind , placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic_stress_disorder .
+The efficacy , safety , and tolerance of pentoxifylline -LRB- Trental , Hoechst-Roussel Pharmaceuticals , Inc. -RRB- in the treatment of intermittent_claudication associated with chronic_occlusive_arterial_disease -LRB- COAD -RRB- were evaluated in a double-blind , placebo-controlled , parallel-group , multicenter clinical trial involving a total of 128 outpatients .
+We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls .
+METHODS : Thalidomide was given to 2 patients with EOS -LRB- a 16-year-old girl and an 8-year-old boy -RRB- at an initial dosage of 2 mg/kg/day , and the dosage was increased if necessary .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+In isolated guinea-pig trachea , YM-16638 inhibited the contractions elicited by LTC4 , LTD4 and LTE4 and its IC50 values were 5.7 x 10 -LRB- -8 -RRB- , 1.6 x 10 -LRB- -7 -RRB- and 9.6 x 10 -LRB- -8 -RRB- mol/l , respectively .
+CONCLUSIONS : Identification of an MYH3 mutation in this family with distal_arthrogryposis_type_1 broadens the phenotype associated with MYH3 mutations to include distal_arthrogryposis_types_1 , 2A -LRB- Freeman-Sheldon_syndrome -RRB- , and 2B -LRB- Sheldon-Hall_syndrome -RRB- .
+OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee .
+Metaanalysis using a random-effects model , demonstrated that tetracyclines were associated with a decreased risk of CDI -LRB- odds ratio -LSB- OR -RSB- , 0.62 ; 95 % confidence interval -LSB- CI -RSB- , 0.47-0.81 ; P < .001 -RRB- .
+Height predictions based on three different methods -LRB- Bayley-Pinneau -LSB- BP -RSB- , Tanner-Whitehouse Mark II -LSB- TW II -RSB- , Roche-Wainer-Thissen -LSB- RWT -RSB- -RRB- were compared to adult heights in 19 males with constitutional_tall_stature previously treated with high-dose testosterone_oenanthate for 6 months -LRB- group A -RRB- and 25 untreated tall males -LRB- group B -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Compared with non-use , metformin use was associated with a decreased risk of developing severe_dengue -LRB- adjusted risk ratio -LSB- aRR -RSB- = 0.60 , 95 % confidence interval -LSB- CI -RSB- : 0.37-0.98 , P = 0.04 -RRB- .
+The aim of this study was to investigate the effects of carvacrol on lipopolysaccharide -LRB- LPS -RRB- - induced endotoxemia and acute_lung_injury -LRB- ALI -RRB- in mice .
+AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- .
+Compared with non-use , metformin use was associated with a decreased risk of developing severe_dengue -LRB- adjusted risk ratio -LSB- aRR -RSB- = 0.60 , 95 % confidence interval -LSB- CI -RSB- : 0.37-0.98 , P = 0.04 -RRB- .
+The aim of this study was to assess the efficacy and safety of azathioprine in the treatment of pulmonary_sarcoidosis .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+At 2 h after dosing , frovatriptan reduced the risk of nausea by 14 % -LRB- 95 % CI 6-20 % , P = 0.0005 -RRB- , photophobia 17 % -LRB- 95 % CI 12-22 % , P < 0.0001 -RRB- , and phonophobia 14 % -LRB- 95 % CI 17-20 % , P < 0.0001 -RRB- .
+AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD .
+BACKGROUND : This randomized , double-blind , placebo-controlled trial was designed to assess the efficacy and safety of topiramate in bulimia_nervosa .
+RESULTS : TOS , OSI levels and prolidase activity in patients with AA were found to be significantly higher compared to the control group -LRB- p = 0.02 , p = 0.004 , p < 0.001 , respectively -RRB- , whereas PON1 and arylesterase activities were significantly lower -LRB- p < 0.001 , p = 0.005 , respectively -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls .
+METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout .
+OBJECTIVE : The aim of this double-blind , placebo-controlled study was to evaluate the efficacy and tolerability of ziprasidone in the treatment of adult patients with borderline_personality_disorder .
+This study suggested that IL23R polymorphisms were associated with susceptibility to AS in the Chinese population and that IL23R may be involved in the development of AS .
+Nintedanib , a small molecule receptor tyrosine kinase inhibitor -LRB- TKI -RRB- of platelet-derived_growth_factor_receptor -LRB- PDGFR -RRB- , fibroblast growth factor receptor -LRB- FGFR -RRB- , and vascular_endothelial_growth_factor_receptor -LRB- VEGFR -RRB- , has been approved for IPF after phase III INPULSIS trials in 2014 .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : Thalidomide was given to 2 patients with EOS -LRB- a 16-year-old girl and an 8-year-old boy -RRB- at an initial dosage of 2 mg/kg/day , and the dosage was increased if necessary .
+The objective of this study was to compare the efficacy of flutamide and cyproterone_acetate in the treatment of hirsutism .
+Identification of a novel nonsense mutation in the UNC13D gene from a patient with hemophagocytic_lymphohistiocytosis : a case report .
+BACKGROUND : The aim of this study was to evaluate the efficacy of tianeptine , an antidepressant that acts by increasing serotonin reuptake , in the treatment of posttraumatic_stress_disorder and to compare the effects of tianeptine and fluoxetine , an antidepressant from the selective serotonin reuptake inhibitors class .
+A multicentre , prospective , randomized , double-blind , parallel group study was undertaken to compare the efficacy and tolerability of topical terbinafine with topical clotrimazole in the treatment of interdigital_tinea_pedis .
+However , homocysteine levels in patients with neovascular_glaucoma were found to be significantly higher than the control group -LRB- p < 0.001 -RRB- .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+The aim of this study was to assess the efficacy and safety of azathioprine in the treatment of pulmonary_sarcoidosis .
+The aim of this study was to assess the efficacy and safety of azathioprine in the treatment of pulmonary_sarcoidosis .
+It was observed that the urine levels of TWEAK in patients with LN were significantly elevated compared with those in the other groups -LRB- P < 0.05 -RRB- .
+We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls .
+METHODS : Bezafibrate -LRB- 400 mg/day -RRB- was orally administered to 7 consecutive patients with PSC , and we analyzed their clinical features and the drug efficacy in terms of the effect on hepatobiliary enzymes , including ALP , gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- , aspartate_aminotransferase -LRB- AST -RRB- , and alanine_aminotransferase -LRB- ALT -RRB- after 6 months .
+We have typed genomic DNA for the presence of the putative KIR loci KIR2DL1 , KIR2DL2 , KIR2DL3 , KIR2DL4 , KIR3DL1 , KIR3DL2 , KIR3DL3 , KIR2DS1 , KIR2DS2 , KIR2DS3 , KIR2DS4 , KIR2DS5 , and KIR3DS1 using modified polymerase chain reaction sequence-specific primers .
+Cinacalcet HCl , an allosteric modulator of the calcium-sensing_receptor -LRB- CaR -RRB- , has recently been approved for the treatment of secondary_hyperparathyroidism in patients with chronic kidney_disease on dialysis , due to its suppressive effect on parathyroid_hormone -LRB- PTH -RRB- secretion .
+The aim of this study was to assess the efficacy and safety of azathioprine in the treatment of pulmonary_sarcoidosis .
+We examined the function of CXCR3 signaling in EAE using mice that were deficient for CXCR3 -LRB- CXCR3 -LRB- - / - -RRB- -RRB- .
+Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- .
+DESIGN AND METHODS : In this genotype-phenotype analysis we screened the coding sequence and intron-exon boundaries of RPS14 , RPS16 , RPS24 , RPL5 , RPL11 , and RPL35A in 92 Italian patients with Diamond-Blackfan_anemia who were negative for RPS19 mutations .
+We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls .
+CONCLUSION : This study confirms that mutations in ASPM are the most common cause of MCPH , that ASPM mutations are restricted to individuals with an MCPH phenotype , and that ASPM testing in primary_microcephaly is clinically useful .
+A randomized , double-blind , placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic_stress_disorder .
+To the best of our knowledge , this is the first report of BRIP1 mutation in MBC in the Indian population .
+An objective causality assessment using the Naranjo probability scale suggested that famciclovir was the probable cause of LCV in this patient .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout : a phase 3 , multicentre , randomized , double-blind , double-dummy , active-controlled , parallel-group study .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+A randomized , double-blind , placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic_stress_disorder .
+Discovery of 1 - -LSB- 2-Fluoro-4 - -LRB- 1H-pyrazol-1-yl -RRB- phenyl -RSB- -5 - methoxy-3 - -LRB- 1-phenyl-1H-pyrazol-5-yl -RRB- pyridazin-4 -LRB- 1H -RRB- - one -LRB- TAK-063 -RRB- , a Highly Potent , Selective , and Orally Active Phosphodiesterase_10A -LRB- PDE10A -RRB- Inhibitor .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+We have shown that non-Alp GBS differ from Alp GBS in the region surrounding the insertion site of Alp genes of Alp GBS as well as in their content of other surface proteins and that PCR for the upstream flanking region of the Alp gene may be useful for differentiation between Alp and non-Alp GBS .
+We believe this is the first report of successful use of thalidomide in a human being with CRPS 1 , and we therefore recommend that thalidomide should be considered in the treatment of CRPS 1 .
+BACKGROUND : The aim of this study was to evaluate the efficacy of tianeptine , an antidepressant that acts by increasing serotonin reuptake , in the treatment of posttraumatic_stress_disorder and to compare the effects of tianeptine and fluoxetine , an antidepressant from the selective serotonin reuptake inhibitors class .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee .
+OBJECTIVE : The purpose of this study was to evaluate the efficacy and safety of ciclesonide in the treatment of perennial_allergic_rhinitis .
+OBJECTIVE : To determine whether serum interleukin_6 -LRB- IL-6 -RRB- , oncostatin_M -LRB- OSM -RRB- , soluble IL-6 receptor -LRB- sIL-6R -RRB- , and soluble gp130 -LRB- sgp130 -RRB- levels in patients with systemic_sclerosis -LRB- SSc -RRB- are elevated and whether they are correlated with the clinical or serological features of the disease .
+OBJECTIVE : The aim of this double-blind , placebo-controlled study was to evaluate the efficacy and tolerability of ziprasidone in the treatment of adult patients with borderline_personality_disorder .
+For production of monoclonal antibodies against domoic_acid , a causative agent of amnesic_shellfish_poisoning , three immunogens , domoic_acid conjugated with bovine serum_albumin -LRB- BSA -RRB- , ovalbumin -LRB- OVA -RRB- and human gamma globulin -LRB- HGG -RRB- , were prepared .
+PATIENTS AND METHODS : Patients with stage III-IVb NPC received NAB-paclitaxel -LRB- 260mg/m <sup> 2 </sup> -RRB- combined with cisplatin -LRB- 80mg/m <sup> 2 </sup> -RRB- intravenously on days 1 and 22 , followed by cisplatin -LRB- 80mg/m <sup> 2 </sup> -RRB- on days 43 and 64 , concomitant with intensity-modulated radiation therapy .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout .
+PATIENTS AND METHODS : Patients with stage III-IVb NPC received NAB-paclitaxel -LRB- 260mg/m <sup> 2 </sup> -RRB- combined with cisplatin -LRB- 80mg/m <sup> 2 </sup> -RRB- intravenously on days 1 and 22 , followed by cisplatin -LRB- 80mg/m <sup> 2 </sup> -RRB- on days 43 and 64 , concomitant with intensity-modulated radiation therapy .
+RESULTS : MRSA VAP patients treated with vancomycin had an average hospital length of stay -LRB- LOS -RRB- of 49 days -LRB- range 9-99 days -RRB- , an average intensive care unit -LRB- ICU -RRB- LOS of 43 days -LRB- range 6-98 days -RRB- , and average ventilator days of 34.4 -LRB- range 3-76 days -RRB- .
+A binary logistic regression analysis showed that GLU -LRB- odds ratio -LSB- OR -RSB- , 5.052 ; P < 0.01 -RRB- and TC -LRB- OR , 1.074 ; P < 0.01 -RRB- may be risk factors for CP , whereas HDL-c may be a CP protective factor -LRB- OR , 0.833 ; P < 0.01 -RRB- .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+To evaluate the effectiveness of thalidomide for epistaxis in hereditary_hemorrhagic_telangiectasia -LRB- HHT -RRB- , 7 HHT patients with recurrent epistaxis were treated with thalidomide at an initial dose of 50 mg/d , gradually increasing to 100 mg/d if needed .
+The primary aim of this study was to compare the efficacy and safety of single-dose fluconazole and a 7-day regimen of itraconazole for the treatment of oropharyngeal_candidiasis in human_immunodeficiency_virus -LRB- HIV -RRB- - positive patients .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+A double-blind , placebo-controlled study was performed to assess whether a new calcium antagonist , nisoldipine , in doses of either 5 mg or 10 mg daily , in combination with beta-adrenergic-blocking_drugs -LRB- combination therapy -RRB- was more effective than beta-adrenergic-blocking_drugs alone -LRB- single therapy -RRB- in the treatment of chronic_stable_angina .
+METHOD : The study was a randomized , double-blind , parallel-group , flexible-dose comparison of sertraline and placebo in outpatients with a DSM-III-R diagnosis of panic_disorder with or without agoraphobia .
+We aimed to compare total_oxidant_status -LRB- TOS -RRB- , total_antioxidant_status -LRB- TAS -RRB- , oxidative stress index -LRB- OSI -RRB- , and prolidase levels of SSc patients and healthy controls .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS/DESIGN : This is a multicentre randomised , double-blind , placebo-controlled feasibility study of glycopyrronium_bromide -LRB- glycopyrrolate -RRB- and hyoscine_hydrobromide -LRB- hyoscine -RRB- in patients with clozapine-induced_hypersalivation .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol_3,4,5-trisphosphate -LRB- PtdIns -LRB- 3,4,5 -RRB- P -LRB- 3 -RRB- -RRB- , but not PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- , although both lipids were found to support phosphorylation of Akt .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+During the median follow-up of 14 months -LRB- range , 0-111 months -RRB- , the overall_survival -LRB- OS -RRB- of ASXL1 CMML patients was significantly inferior to that of ASXL1 CMML patients with a median survival of 11 months and 19 months , respectively -LRB- log-rank P = 0.049 -RRB- .
+In this study , we want to examine the effects of colchicine on platelet density , mean platelet volume -LRB- MPV -RRB- , neutrophil-lymphocyte ratio -LRB- NLR -RRB- , platelet-lymphocyte ratio -LRB- PLR -RRB- and red cell distribution width -LRB- RDW -RRB- of the patients with RAS .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Unstimulated CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells from FIV -LRB- + -RRB- cats significantly suppress the proliferative response and the IL-2 production of Con A-stimulated autologous CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells compared with unstimulated CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells from FIV -LRB- - -RRB- cats .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : Thalidomide was given to 2 patients with EOS -LRB- a 16-year-old girl and an 8-year-old boy -RRB- at an initial dosage of 2 mg/kg/day , and the dosage was increased if necessary .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : We conducted an open-label study in which ivermectin was administered in a single oral dose of 200 micrograms per kilogram to 11 otherwise healthy patients with scabies and to 11 patients with scabies who were also infected with the human_immunodeficiency_virus -LRB- HIV -RRB- , 7 of whom had the acquired_immunodeficiency_syndrome .
+A phase 2 , randomized , double-blind , placebo-controlled , dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal_candidiasis .
+Expression of seven genes of the anthocyanin biosynthetic pathway -LRB- phenylalanine ammonia lyase -LSB- PAL -RSB- , chalcone_synthase -LSB- CHS -RSB- , chalcone_isomerase -LSB- CHI -RSB- , flavanone-3-hydroxylase -LSB- F3H -RSB- , dihydroflavonol_4-reductase -LSB- DFR -RSB- , leucoanthocyanidin_dioxygen-ase -LSB- LDOX -RSB- , and UDP_glucose-flavonoid_3-o-glucosyl_transferase -LSB- UFGT -RSB- -RRB- was determined .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS AND RESULTS : Apolipoprotein_E-deficient -LRB- apoE - / - -RRB- mice fed a 1 % cholesterol diet were treated with a selective COX-1 inhibitor -LRB- SC-560 -RRB- , a selective COX-2 inhibitor -LRB- SC-236 -RRB- , or vehicle .
+On day 13 , 20 and 30 post immunization , the content of MDA in the EAE group was obviously higher than that in the control group -LRB- P < 0.05 -RRB- ; the content of MDA in the DXM group was obviously lower than that in the EAE group -LRB- P < 0.05 -RRB- .
+The aim of this study was to assess the efficacy and safety of azathioprine in the treatment of pulmonary_sarcoidosis .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- .
+A binary logistic regression analysis showed that GLU -LRB- odds ratio -LSB- OR -RSB- , 5.052 ; P < 0.01 -RRB- and TC -LRB- OR , 1.074 ; P < 0.01 -RRB- may be risk factors for CP , whereas HDL-c may be a CP protective factor -LRB- OR , 0.833 ; P < 0.01 -RRB- .
+A phase 2 , randomized , double-blind , placebo-controlled , dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal_candidiasis .
+The inhibitory effect of wortmannin on Rap1B activation was overcome by addition of phosphatidylinositol_3,4,5-trisphosphate -LRB- PtdIns -LRB- 3,4,5 -RRB- P -LRB- 3 -RRB- -RRB- , but not PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- , although both lipids were found to support phosphorylation of Akt .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+BACKGROUND : Pregabalin is approved by the US Food and Drug Administration for the treatment of fibromyalgia -LRB- FM -RRB- , diabetic_peripheral_neuropathy -LRB- DPN -RRB- , postherpetic_neuralgia -LRB- PHN -RRB- , and neuropathic_pain due to spinal_cord_injury -LRB- SCI -RRB- .
+Loxapine -LRB- 0.3 mg/kg s.c. -RRB- , olanzapine -LRB- 10 mg/kg s.c. -RRB- and SCH_23390 -LRB- R - -LRB- + -RRB- - chloro-2 , 3 , 4 , 5-tetrahydro-3-methyl-5-phenyl-1-H-3-benzazepine ; 1 mg/kg , s.c. -RRB- , but not clozapine -LRB- 10 mg/kg , s.c. -RRB- , induced catalepsy in rats .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+The purpose of this study was to determine the prevalence of low serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- and testosterone in men with poststroke_hemiplegia .
+CONCLUSIONS : Identification of an MYH3 mutation in this family with distal_arthrogryposis_type_1 broadens the phenotype associated with MYH3 mutations to include distal_arthrogryposis_types_1 , 2A -LRB- Freeman-Sheldon_syndrome -RRB- , and 2B -LRB- Sheldon-Hall_syndrome -RRB- .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+METHODS/DESIGN : This is a multicentre randomised , double-blind , placebo-controlled feasibility study of glycopyrronium_bromide -LRB- glycopyrrolate -RRB- and hyoscine_hydrobromide -LRB- hyoscine -RRB- in patients with clozapine-induced_hypersalivation .
+AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD .
+Health-related quality of life outcomes with prasugrel among medically managed non-ST-segment elevation acute_coronary_syndrome patients : Insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes -LRB- TRILOGY ACS -RRB- trial .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+We conducted a pilot study to evaluate the efficacy of topiramate in trigeminal_neuralgia using a randomized , double-blind , placebo-controlled , two-period crossover design .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+On day 13 , 20 and 30 post immunization , the content of MDA in the EAE group was obviously higher than that in the control group -LRB- P < 0.05 -RRB- ; the content of MDA in the DXM group was obviously lower than that in the EAE group -LRB- P < 0.05 -RRB- .
+This study suggested that IL23R polymorphisms were associated with susceptibility to AS in the Chinese population and that IL23R may be involved in the development of AS .
+It is shown that glutamate and N-methyl-D-aspartate neurotoxicity are prevented by the following compounds : 1-amino-cyclo-pentane-trans-1,3-dicarboxylic_acid , agonist of mGluR1 , _ 2 , _ 3_and_5 ; 3,5-dihydroxyphenylglycine , agonist of mGluR1_and_5 ; S-4-carboxy-3-hydroxyphenylglycine , agonist of mGluR5 and antagonist of mGluR1 ; trans-azetidine-2,4-dicarboxylic_acid , agonist of mGluR5 .
+We have shown that non-Alp GBS differ from Alp GBS in the region surrounding the insertion site of Alp genes of Alp GBS as well as in their content of other surface proteins and that PCR for the upstream flanking region of the Alp gene may be useful for differentiation between Alp and non-Alp GBS .
+In this study , we want to examine the effects of colchicine on platelet density , mean platelet volume -LRB- MPV -RRB- , neutrophil-lymphocyte ratio -LRB- NLR -RRB- , platelet-lymphocyte ratio -LRB- PLR -RRB- and red cell distribution width -LRB- RDW -RRB- of the patients with RAS .
+A binary logistic regression analysis showed that GLU -LRB- odds ratio -LSB- OR -RSB- , 5.052 ; P < 0.01 -RRB- and TC -LRB- OR , 1.074 ; P < 0.01 -RRB- may be risk factors for CP , whereas HDL-c may be a CP protective factor -LRB- OR , 0.833 ; P < 0.01 -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+The aim of this study was to determine whether the single nucleotide polymorphisms -LRB- SNPs -RRB- in the IL-33 gene are associated with susceptibility to AS in a Chinese population .
+To evaluate the relationship between the development of obesity and the hypersecretion of amylin by the pancreas , we examined the effects of 16.7 mmol/L glucose and 10 mmol/L arginine on the secretion of amylin and insulin by isolated perfused pancreata from genetically obese -LRB- fa/fa -RRB- and lean -LRB- Fa / ? -RRB-
+HFS_LTD was blocked by the group I/II mGluR antagonist LY341495 -LRB- -LRB- 2S -RRB- -2-amino-2 - -LSB- -LRB- 1S , _ 2S -RRB- -2-carboxycycloprop-1-yl -RSB- -3 -LRB- xanth-9-yl -RRB- propanoic_acid -RRB- and by the mGluR5-selective antagonist 2-methyl-6 - -LRB- phenylethynyl -RRB- pyridine_hydrochloride -LRB- MPEP -RRB- .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+METHODS : This was an extension of a multi-centre , randomised , double-blind , placebo-controlled base study in which patients with homozygous_sitosterolemia and plasma sitosterol concentrations > 5 mg/dl were randomised 4 : 1 to ezetimibe 10 mg/day -LRB- n = 30 -RRB- or placebo -LRB- n = 7 -RRB- for 8 weeks .
+The purpose of this study was to determine the prevalence of low serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- and testosterone in men with poststroke_hemiplegia .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+The aim of this study was to determine whether the single nucleotide polymorphisms -LRB- SNPs -RRB- in the IL-33 gene are associated with susceptibility to AS in a Chinese population .
+BACKGROUND : Pregabalin is approved by the US Food and Drug Administration for the treatment of fibromyalgia -LRB- FM -RRB- , diabetic_peripheral_neuropathy -LRB- DPN -RRB- , postherpetic_neuralgia -LRB- PHN -RRB- , and neuropathic_pain due to spinal_cord_injury -LRB- SCI -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+OBJECTIVE : The objective of this study was to evaluate the efficacy , tolerability , and safety of mibefradil , a new selective T-type calcium channel blocker , in patients with chronic_stable_angina_pectoris receiving concomitant beta-blocker therapy .
+A double-blind , placebo-controlled study was performed to assess whether a new calcium antagonist , nisoldipine , in doses of either 5 mg or 10 mg daily , in combination with beta-adrenergic-blocking_drugs -LRB- combination therapy -RRB- was more effective than beta-adrenergic-blocking_drugs alone -LRB- single therapy -RRB- in the treatment of chronic_stable_angina .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+PDGF-BB-induced dephosphorylation of cofilin was inhibited by pretreatment with piceatannol -LRB- a spleen_tyrosine_kinase -LSB- Syk -RSB- inhibitor -RRB- , PP2 -LRB- a Src inhibitor -RRB- , or SP600125 -LRB- a c-Jun N-terminal kinase -LSB- JNK -RSB- inhibitor -RRB- , but not by PD98059 , an inhibitor of extracellular_signal-regulated_kinase_1 / 2 .
+HFS_LTD was blocked by the group I/II mGluR antagonist LY341495 -LRB- -LRB- 2S -RRB- -2-amino-2 - -LSB- -LRB- 1S , _ 2S -RRB- -2-carboxycycloprop-1-yl -RSB- -3 -LRB- xanth-9-yl -RRB- propanoic_acid -RRB- and by the mGluR5-selective antagonist 2-methyl-6 - -LRB- phenylethynyl -RRB- pyridine_hydrochloride -LRB- MPEP -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee .
+In this study , we want to examine the effects of colchicine on platelet density , mean platelet volume -LRB- MPV -RRB- , neutrophil-lymphocyte ratio -LRB- NLR -RRB- , platelet-lymphocyte ratio -LRB- PLR -RRB- and red cell distribution width -LRB- RDW -RRB- of the patients with RAS .
+In conclusion , we did not detect any known or likely pathogenic variants in the <i> ISL1 </i> gene in 125 Swedish BEEC patients , indicating that variation in the <i> ISL1 </i> gene is not a common genetic mechanism of BEEC development in the Swedish population .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee .
+Catatonia induced by etorphine -LRB- 0.004 mg/kg s.c. -RRB- and constipation induced by etorphine -LRB- 0.004 mg/kg s.c. -RRB- and D-Ala2-D-Leu5-enkephalin -LRB- 0.1 mg/kg i.p. -RRB- were completely antagonized by bremazocine -LRB- 0.03-8 mg/kg i.p. -RRB- .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+We have shown that non-Alp GBS differ from Alp GBS in the region surrounding the insertion site of Alp genes of Alp GBS as well as in their content of other surface proteins and that PCR for the upstream flanking region of the Alp gene may be useful for differentiation between Alp and non-Alp GBS .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : Bezafibrate -LRB- 400 mg/day -RRB- was orally administered to 7 consecutive patients with PSC , and we analyzed their clinical features and the drug efficacy in terms of the effect on hepatobiliary enzymes , including ALP , gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- , aspartate_aminotransferase -LRB- AST -RRB- , and alanine_aminotransferase -LRB- ALT -RRB- after 6 months .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+A double-blind , randomized , prospective , parallel-group study was conducted to evaluate the efficacy and safety of MTA in the treatment of asthmatic_crisis in children 2 to 6 years of age .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Flow cytometric assay showed that treatment of AGS cells with tangeretin decreased the mitochondrial membrane potential -LRB- MMP -RRB- in a dose-dependent manner , which indicated that mitochondrial_dysfunction was involved in the tangeretin-induced apoptosis .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Administration of AEE788 , alone and in combination with paclitaxel , to athymic nude_mice bearing s.c. ATC xenografts inhibited the growth of ATC xenografts by 44 % and 69 % , respectively , compared with the control group .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+A phase 2 , randomized , double-blind , placebo-controlled , dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal_candidiasis .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Serum CTRP1 levels in all subjects and serum tumor_necrosis_factor-a -LRB- TNF-a -RRB- , interleukin-1b -LRB- IL-1b -RRB- , and interleukin-6 -LRB- IL-6 -RRB- levels in KD patients were measured using enzyme-linked immunosorbent assay.ResultsCompared with the HC group , serum CTRP1 levels were significantly elevated in the KD group .
+Aqueous humor outflow facility was measured by a two-level constant-pressure perfusion METHOD : <AbstractText Label="RESULTS" NlmCategory="RESULTS"> PGE2 , ONO-AE1-259-01 -LRB- EP2 agonist -RRB- , and ONO-AE1-329 -LRB- EP4 agonist -RRB- significantly reduced IOP in a dose-dependent manner , whereas ONO-DI-004 -LRB- EP1 agonist -RRB- and ONO-AE-248 -LRB- EP3 agonist -RRB- had no effect .
+A double-blind , placebo-controlled study was performed to assess whether a new calcium antagonist , nisoldipine , in doses of either 5 mg or 10 mg daily , in combination with beta-adrenergic-blocking_drugs -LRB- combination therapy -RRB- was more effective than beta-adrenergic-blocking_drugs alone -LRB- single therapy -RRB- in the treatment of chronic_stable_angina .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+Serum CTRP1 levels in all subjects and serum tumor_necrosis_factor-a -LRB- TNF-a -RRB- , interleukin-1b -LRB- IL-1b -RRB- , and interleukin-6 -LRB- IL-6 -RRB- levels in KD patients were measured using enzyme-linked immunosorbent assay.ResultsCompared with the HC group , serum CTRP1 levels were significantly elevated in the KD group .
+We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma .
+OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee .
+RESULTS : The median duration of otorrhea in the prednisolone group was 1.0 days -LRB- 25 % to 75 % range , 1.0 to 2.0 days -RRB- , compared with 3.0 days -LRB- 25 % to 75 % range , 2.0 to 4.0 days -RRB- in the children receiving placebo -LRB- P < .001 -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+CONCLUSION : This study confirms that mutations in ASPM are the most common cause of MCPH , that ASPM mutations are restricted to individuals with an MCPH phenotype , and that ASPM testing in primary_microcephaly is clinically useful .
+BACKGROUND : This randomized , double-blind , placebo-controlled trial was designed to assess the efficacy and safety of topiramate in bulimia_nervosa .
+METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout .
+METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout .
+MEASUREMENTS : Anemia was defined as a hemoglobin level of less than 10 g/dL , hyperkalemia as a potassium level greater than 5.5 mEq/L , acidosis as a bicarbonate level of less than 21 mEq/L , and hyperphosphatemia as a phosphorus level greater than 4.6 mg/dL .
+Expression of seven genes of the anthocyanin biosynthetic pathway -LRB- phenylalanine ammonia lyase -LSB- PAL -RSB- , chalcone_synthase -LSB- CHS -RSB- , chalcone_isomerase -LSB- CHI -RSB- , flavanone-3-hydroxylase -LSB- F3H -RSB- , dihydroflavonol_4-reductase -LSB- DFR -RSB- , leucoanthocyanidin_dioxygen-ase -LSB- LDOX -RSB- , and UDP_glucose-flavonoid_3-o-glucosyl_transferase -LSB- UFGT -RSB- -RRB- was determined .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : This was a multicenter , randomized , double-blind , placebo-controlled study designed to determine the efficacy and safety of desloratadine in the treatment of moderate-to-severe CIU .
+The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS .
+AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD .
+Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout : a phase 3 , multicentre , randomized , double-blind , double-dummy , active-controlled , parallel-group study .
+Cinacalcet HCl , an allosteric modulator of the calcium-sensing_receptor -LRB- CaR -RRB- , has recently been approved for the treatment of secondary_hyperparathyroidism in patients with chronic kidney_disease on dialysis , due to its suppressive effect on parathyroid_hormone -LRB- PTH -RRB- secretion .
+Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+The agonists and antagonists used were iloprost -LRB- IP agonist -RRB- , ONO-DI-004 -LRB- EP1 agonist -RRB- , ONO-AE1-259 -LRB- EP2 agonist -RRB- , sulprostone -LRB- EP3 agonist -RRB- , ONO-AE1-329 -LRB- EP4 agonist -RRB- , CAY10441 -LRB- IP antagonist -RRB- , ONO-8713 -LRB- EP1 antagonist -RRB- , DG-041 -LRB- EP3 antagonist -RRB- and ONO-AE3-208 -LRB- EP4 antagonist -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MEASUREMENTS : Anemia was defined as a hemoglobin level of less than 10 g/dL , hyperkalemia as a potassium level greater than 5.5 mEq/L , acidosis as a bicarbonate level of less than 21 mEq/L , and hyperphosphatemia as a phosphorus level greater than 4.6 mg/dL .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+A prospective randomized double-blind study was conducted to evaluate the efficacy of sodium_benzoate in the treatment of acute portal-systemic_encephalopathy .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+PDGF-BB-induced dephosphorylation of cofilin was inhibited by pretreatment with piceatannol -LRB- a spleen_tyrosine_kinase -LSB- Syk -RSB- inhibitor -RRB- , PP2 -LRB- a Src inhibitor -RRB- , or SP600125 -LRB- a c-Jun N-terminal kinase -LSB- JNK -RSB- inhibitor -RRB- , but not by PD98059 , an inhibitor of extracellular_signal-regulated_kinase_1 / 2 .
+To the best of our knowledge , this is the first reported case of thrombotic_thrombocytopenic_purpura associated with the use of moxifloxacin .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+The objective of this study was to compare the efficacy of flutamide and cyproterone_acetate in the treatment of hirsutism .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+This study aimed to evaluate the efficacy of metformin as an adjunct to scaling and root planing -LRB- SRP -RRB- in the treatment of chronic_periodontitis .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout : a phase 3 , multicentre , randomized , double-blind , double-dummy , active-controlled , parallel-group study .
+A randomized , double-blind , placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic_stress_disorder .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+OBJECTIVES : An open-label study was performed to assess the efficacy and safety of terbinafine in the treatment of eumycetoma .
+The objective of this study was to evaluate the efficacy of fluvoxamine in the treatment of pathological_gambling .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Loxapine -LRB- 0.3 mg/kg s.c. -RRB- , olanzapine -LRB- 10 mg/kg s.c. -RRB- and SCH_23390 -LRB- R - -LRB- + -RRB- - chloro-2 , 3 , 4 , 5-tetrahydro-3-methyl-5-phenyl-1-H-3-benzazepine ; 1 mg/kg , s.c. -RRB- , but not clozapine -LRB- 10 mg/kg , s.c. -RRB- , induced catalepsy in rats .
+There was a correlation between serum levels of alkaline phosphatase -LRB- r = 0.3 , p less than 0.01 -RRB- , phosphate -LRB- r = 0.42 , p less than 0.01 -RRB- and serum osteocalcin levels .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+We determined genotype and allele frequencies of ALDH2 , CYP2E1 , ADH2 , and ADH3 in male Korean patients with alcoholic_cirrhosis -LRB- n = 56 -RRB- , alcoholics without evidence of liver_disease -LRB- n = 52 -RRB- , and nondrinkers -LRB- n = 64 -RRB- by using PCR or PCR-directed mutagenesis followed by restriction enzyme digestion .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Mean serum levels of PP in patients with gastrinomas -LRB- 67 + / - 31 pmol/l -LRB- SD -RRB- -RRB- were significantly -LRB- P less than 0.01 -RRB- higher than in the normal subjects -LRB- 47 + / - 15 pmol/l -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS .
+A multicentre , prospective , randomized , double-blind , parallel group study was undertaken to compare the efficacy and tolerability of topical terbinafine with topical clotrimazole in the treatment of interdigital_tinea_pedis .
+METHODS : Thalidomide was given to 2 patients with EOS -LRB- a 16-year-old girl and an 8-year-old boy -RRB- at an initial dosage of 2 mg/kg/day , and the dosage was increased if necessary .
+This LPS-induced_dye_leakage was suppressed by phosphodiesterase inhibitors , including pentoxifylline -LRB- 160 mg kg-1 -RRB- , milrinone -LRB- 5 - 10 mg kg-1 -RRB- , rolipram -LRB- 0.5 - 10 mg kg-1 -RRB- and zaprinast -LRB- 5 - 10 mg kg-1 -RRB- .
+The purpose of this study was to determine the prevalence of low serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- and testosterone in men with poststroke_hemiplegia .
+OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee .
+Cidofovir -LRB- Vistide -RRB- has been officially approved for the treatment of CMV_retinitis in AIDS patients , tenofovir_disoproxil_fumarate -LRB- Viread -RRB- has been approved for the treatment of HIV_infections -LRB- i.e. , AIDS -RRB- , and adefovir_dipivoxil -LRB- Hepsera -RRB- has been approved for the treatment of chronic hepatitis_B .
+We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma .
+Twelve patients with either asymptomatic PBC -LRB- group 1 , n = 6 -RRB- or PBC with a poor response to UDCA -LRB- group 2 , n = 6 -RRB- , were compared to healthy controls -LRB- group 3 , n = 6 -RRB- .
+OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee .
+Mean serum levels of PP in patients with gastrinomas -LRB- 67 + / - 31 pmol/l -LRB- SD -RRB- -RRB- were significantly -LRB- P less than 0.01 -RRB- higher than in the normal subjects -LRB- 47 + / - 15 pmol/l -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+HOMA-IR , IL-6 , TNF-a , MDA and ox-LDL levels in patients with eclampsia were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- , and the adiponectin_receptor_2 and COX-2 expression levels in the placental tissue were significantly higher than those in patients without eclampsia -LRB- p < 0.05 -RRB- .
+Ropinirole in the treatment of patients with restless_legs_syndrome : a US-based randomized , double-blind , placebo-controlled clinical trial .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Prenatal diagnosis of a novel mutation , c. 529C > T -LRB- p.Q177X -RRB- , in the BCKDHA gene in a family with maple_syrup_urine_disease .
+A double-blind , placebo-controlled crossover trial was undertaken to determine the efficacy of meclofenamate_sodium in the treatment of menorrhagia .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+A double-blind , randomized , prospective , parallel-group study was conducted to evaluate the efficacy and safety of MTA in the treatment of asthmatic_crisis in children 2 to 6 years of age .
+We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma .
+Bosentan therapy in patients with Eisenmenger_syndrome : a multicenter , double-blind , randomized , placebo-controlled study .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Pretreatment with tripelennamine -LRB- histamine_H1-receptor antagonist , 40 mg/kg i.p. -RRB- prior to the administration of compound 48/80 reduced the effect of compound 48/80 on drinking , but pretreatment with cimetidine -LRB- histamine_H2-receptor antagonist , 40 mg/kg i.p. -RRB- or propranolol -LRB- beta-adrenoceptor antagonist , 10 mg/kg i.p. -RRB- had no effect .
+Results of a double-blind , randomized , placebo-controlled , parallel study in 37 patients indicate that terfenadine , 60 mg bid , is significantly more effective than placebo and as effective as hydroxyzine , 25 mg qid , in the treatment of chronic_idiopathic_urticaria without causing the somnolence that was associated with the use of hydroxyzine .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Mean serum neopterin levels in SP and PMF patients -LRB- 10.72 + / - 0.98 nmol/L ; 14.08 + / - 3.86 nmol/L , respectively -RRB- were significantly higher than those of control group -LRB- 5.30 + / - 0.47 nmol/L -RRB- -LRB- P < 0.05 -RRB- .
+RESULTS : The median duration of otorrhea in the prednisolone group was 1.0 days -LRB- 25 % to 75 % range , 1.0 to 2.0 days -RRB- , compared with 3.0 days -LRB- 25 % to 75 % range , 2.0 to 4.0 days -RRB- in the children receiving placebo -LRB- P < .001 -RRB- .
+8-Hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- and buspirone , putative 5-HT1A agonists , m-trifluoromethylphenyl-piperazine -LRB- TFMPP -RRB- and 7-trifluoromethyl-4 -LRB- 4-methyl-1-piperazinyl -RRB- - pyrrolo -LRB- 1,2-1a -RRB- quinoxaline -LRB- CGS 12066B -RRB- , 5-HT1B agonists , and 5-carboxamidotryptamine -LRB- 5-CT -RRB- , a mixed 5-HT1A_and_5HT1B agonist , were used .
+The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS .
+ADAMTS4 showed a weak correlation with high-sensitivity C-reactive_protein -LRB- hs-CRP -RRB- ; however , no significant correlation was found between ADAMTS4 and troponin_T -LRB- TnT -RRB- in ACS patients .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS/DESIGN : This is a multicentre randomised , double-blind , placebo-controlled feasibility study of glycopyrronium_bromide -LRB- glycopyrrolate -RRB- and hyoscine_hydrobromide -LRB- hyoscine -RRB- in patients with clozapine-induced_hypersalivation .
+OBJECTIVE : To compare the efficacy and safety of celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , with those of naproxen , a nonsteroidal anti-inflammatory drug -LRB- NSAID -RRB- , and placebo in the treatment of osteoarthritis_of_the_knee .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma .
+To evaluate the relationship between the development of obesity and the hypersecretion of amylin by the pancreas , we examined the effects of 16.7 mmol/L glucose and 10 mmol/L arginine on the secretion of amylin and insulin by isolated perfused pancreata from genetically obese -LRB- fa/fa -RRB- and lean -LRB- Fa / ? -RRB-
+The aim of the present study was to evaluate the effects of the 5-HT6 receptor agonist , EMD_386088 , on the ketamine-induced deficits in the attentional set-shifting task -LRB- ASST -RRB- , novel object recognition -LRB- NOR -RRB- task and prepulse inhibition -LRB- PPI -RRB- task in rats .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+The ENOs were totally blocked by the GABAA receptor antagonist bicuculline and they were also substantially reduced by the glutamatergic antagonists D,L-2-amino-5-phosphonovaleric _ acid -LRB- D , L-APV -RRB- and 6-cyano-7-nitroquinoxaline-2,3-dione -LRB- CNQX -RRB- .
+Eight patients with myeloproliferative_disorders , five with polycythaemia rubra vera -LRB- PRV -RRB- and three with essential thrombocythaemia -LRB- ET -RRB- , have been treated with the anti-folate drug Pyrimethamine for periods ranging from 1 to 24 years .
+METHODS : Bezafibrate -LRB- 400 mg/day -RRB- was orally administered to 7 consecutive patients with PSC , and we analyzed their clinical features and the drug efficacy in terms of the effect on hepatobiliary enzymes , including ALP , gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- , aspartate_aminotransferase -LRB- AST -RRB- , and alanine_aminotransferase -LRB- ALT -RRB- after 6 months .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+Using in vitro protein tyrosine phosphatase -LRB- PTPase -RRB- assays , we found that sodium_stibogluconate , a drug used in treatment of leishmaniasis , is a potent inhibitor of PTPases Src homology PTPase1 -LRB- SHP-1 -RRB- , SHP-2 , and PTP1B but not the dual-specificity phosphatase mitogen-activated protein kinase phosphatase 1 .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHOD : The study was a randomized , double-blind , parallel-group , flexible-dose comparison of sertraline and placebo in outpatients with a DSM-III-R diagnosis of panic_disorder with or without agoraphobia .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+However , a significant association was detected between the LIFR gene polymorphisms and schizophrenia patients with persecutory_delusion -LRB- rs2071236 , OR = 2.18 , 95 % CI = 1.20-3.94 , P = 0.009 in the overdominant model ; rs6862038 , OR = 2.08 , 95 % CI = 1.16-3.74 , P = 0.013 in the overdominant model -RRB- .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+The plasma trough C/D ratio of apixaban in patients with CYP3A5 * 1 / * 3 or * 3 / * 3 genotypes was also significantly higher than that in patients with the CYP3A5 * 1 / * 1 genotype -LRB- P < 0.05 -RRB- .
+The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS .
+The present study investigated the effects of systemic administration of the putative dopamine_D3_receptor agonist 7-hydroxy-N , N-di-n-propyl-2-aminotetralin -LRB- 7-OH-DPAT -RRB- on the acquisition and expression of morphine-induced place preference in male Wistar_rats .
+OBJECTIVE : To determine whether serum interleukin_6 -LRB- IL-6 -RRB- , oncostatin_M -LRB- OSM -RRB- , soluble IL-6 receptor -LRB- sIL-6R -RRB- , and soluble gp130 -LRB- sgp130 -RRB- levels in patients with systemic_sclerosis -LRB- SSc -RRB- are elevated and whether they are correlated with the clinical or serological features of the disease .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD .
+To compare the efficacy and safety of mebendazole and secnidazole in the treatment of giardiasis in adult patients , a single-centre , parallel group , open-label , randomized non-inferiority trial was carried out .
+Using in vitro protein tyrosine phosphatase -LRB- PTPase -RRB- assays , we found that sodium_stibogluconate , a drug used in treatment of leishmaniasis , is a potent inhibitor of PTPases Src homology PTPase1 -LRB- SHP-1 -RRB- , SHP-2 , and PTP1B but not the dual-specificity phosphatase mitogen-activated protein kinase phosphatase 1 .
+The agonists and antagonists used were iloprost -LRB- IP agonist -RRB- , ONO-DI-004 -LRB- EP1 agonist -RRB- , ONO-AE1-259 -LRB- EP2 agonist -RRB- , sulprostone -LRB- EP3 agonist -RRB- , ONO-AE1-329 -LRB- EP4 agonist -RRB- , CAY10441 -LRB- IP antagonist -RRB- , ONO-8713 -LRB- EP1 antagonist -RRB- , DG-041 -LRB- EP3 antagonist -RRB- and ONO-AE3-208 -LRB- EP4 antagonist -RRB- .
+We performed a multicenter , randomized , placebo-controlled , double-blind , phase 3 trial to evaluate the efficacy and safety of prucalopride in children -LRB- 6-18 years old -RRB- with functional constipation .
+BACKGROUND : This randomized , double-blind , placebo-controlled trial was designed to assess the efficacy and safety of topiramate in bulimia_nervosa .
+The present study evaluated whether 2-deoxy-D-glucose -LRB- 2DG , 400 mg/kg -RRB- hyperphagia was affected by methysergide -LRB- 0.5-5 mg/kg -RRB- , ritanserin -LRB- 0.25-2.5 mg/kg -RRB- , or ICS-205,930 -LRB- 0.5-5 mg/kg -RRB- alone or in combination with naltrexone -LRB- 0.25 and 2.5 mg/kg -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+A double-blind , randomized , prospective , parallel-group study was conducted to evaluate the efficacy and safety of MTA in the treatment of asthmatic_crisis in children 2 to 6 years of age .
+A phase 2 , randomized , double-blind , placebo-controlled , dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal_candidiasis .
+The aim of this study was to determine whether the single nucleotide polymorphisms -LRB- SNPs -RRB- in the IL-33 gene are associated with susceptibility to AS in a Chinese population .
+Among participants with a history of hypertension , the use of furosemide , when compared with the use of other antihypertensive medications , was associated with increased risk for developing P-HPTH ; age-adjusted RR for incident P-HPTH was 1.79 -LRB- 95 % CI , 1.15-2.79 -RRB- and multivariate-adjusted RR was 1.71 -LRB- 95 % CI , 1.08-2.71 -RRB- .
+Long-chain omega-3_fatty_acids , eicosapentaenoic_acid -LRB- EPA -RRB- -LRB- 20:5 n-3 -RRB- and docosahexaenoic_acid -LRB- DHA -RRB- -LRB- 22:6 n-3 -RRB- , are associated with decreased triglyceride levels in hypertriglyceridemic patients and decreased risk of developing coronary_heart_disease -LRB- CHD -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+BACKGROUND : This randomized , double-blind , placebo-controlled trial was designed to assess the efficacy and safety of topiramate in bulimia_nervosa .
+A randomized , double-blind , placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic_stress_disorder .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+The adenosine_A2A_receptor antagonist , 1,3,7-trimethyl-8 - -LRB- 3-chlorostyryl -RRB- xanthine -LRB- CSC -RRB- , significantly decreased catalepsy induced by raclopride and haloperidol , while the adenosine A1 receptor antagonist , 1,3-dimethyl-8-phenylxanthine -LRB- 8-PT -RRB- , was ineffective .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+8-Hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- and buspirone , putative 5-HT1A agonists , m-trifluoromethylphenyl-piperazine -LRB- TFMPP -RRB- and 7-trifluoromethyl-4 -LRB- 4-methyl-1-piperazinyl -RRB- - pyrrolo -LRB- 1,2-1a -RRB- quinoxaline -LRB- CGS 12066B -RRB- , 5-HT1B agonists , and 5-carboxamidotryptamine -LRB- 5-CT -RRB- , a mixed 5-HT1A_and_5HT1B agonist , were used .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+8-Hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- and buspirone , putative 5-HT1A agonists , m-trifluoromethylphenyl-piperazine -LRB- TFMPP -RRB- and 7-trifluoromethyl-4 -LRB- 4-methyl-1-piperazinyl -RRB- - pyrrolo -LRB- 1,2-1a -RRB- quinoxaline -LRB- CGS 12066B -RRB- , 5-HT1B agonists , and 5-carboxamidotryptamine -LRB- 5-CT -RRB- , a mixed 5-HT1A_and_5HT1B agonist , were used .
+MEASUREMENTS : Anemia was defined as a hemoglobin level of less than 10 g/dL , hyperkalemia as a potassium level greater than 5.5 mEq/L , acidosis as a bicarbonate level of less than 21 mEq/L , and hyperphosphatemia as a phosphorus level greater than 4.6 mg/dL .
+METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout .
+BACKGROUND : This randomized , double-blind , placebo-controlled trial was designed to assess the efficacy and safety of topiramate in bulimia_nervosa .
+To compare the efficacy and safety of mebendazole and secnidazole in the treatment of giardiasis in adult patients , a single-centre , parallel group , open-label , randomized non-inferiority trial was carried out .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+Using in vitro protein tyrosine phosphatase -LRB- PTPase -RRB- assays , we found that sodium_stibogluconate , a drug used in treatment of leishmaniasis , is a potent inhibitor of PTPases Src homology PTPase1 -LRB- SHP-1 -RRB- , SHP-2 , and PTP1B but not the dual-specificity phosphatase mitogen-activated protein kinase phosphatase 1 .
+ADAMTS4 showed a weak correlation with high-sensitivity C-reactive_protein -LRB- hs-CRP -RRB- ; however , no significant correlation was found between ADAMTS4 and troponin_T -LRB- TnT -RRB- in ACS patients .
+The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- , interleukin_18 -LRB- IL-18 -RRB- , and interleukin_10 -LRB- IL-10 -RRB- in elderly patients with ACS .
+In this report , we describe the in vitro and in vivo anti-inflammatory properties of a potent histamine_H4_receptor antagonist , A-940894 -LRB- 4-piperazin-1-yl-6,7-dihydro-5H-benzo -LSB- 6,7 -RSB- cyclohepta -LSB- 1,2-d -RSB- pyrimidin-2-ylamine -RRB- .
+METHODS : Thalidomide was given to 2 patients with EOS -LRB- a 16-year-old girl and an 8-year-old boy -RRB- at an initial dosage of 2 mg/kg/day , and the dosage was increased if necessary .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : Twelve patients with biopsy-proven NASH were randomized to sitagliptin -LRB- 100 mg daily -RRB- -LRB- n = 6 -RRB- or placebo -LRB- n = 6 -RRB- for 24 wk .
+The aim of the study was to evaluate the presence of mutations and single nucleotide polymorphisms in PITX3 gene in clinically diagnosed multisystem_atrophy -LRB- MSA -RRB- , progressive_supranuclear_palsy -LRB- PSP -RRB- , and corticobasal_degeneration -LRB- CBD -RRB- .
+OBJECTIVES : The purpose of this study was to investigate the role of ivabradine in the treatment_of_symptomatic_inappropriate_sinus_tachycardia using a double-blind , placebo-controlled , crossover design .
+The aim of this randomized double-blind , placebo-controlled , parallel-group study was to evaluate the efficacy , safety , and tolerability of pregabalin in combination with oxycodone or placebo , in patients with either postherpetic_neuralgia -LRB- PHN -RRB- or painful_diabetic_neuropathy -LRB- PDN -RRB- .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+Eighty-one FD patients were treated with acotiamide -LRB- 300 mg/day -RRB- -LRB- n = 35 -RRB- , acotiamide -LRB- 300 mg/day -RRB- and rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 28 -RRB- , or rabeprazole -LRB- 10 mg/day -RRB- -LRB- n = 18 -RRB- for a period of 4 weeks and followed after 4 weeks of no treatment .
+Effects of pentamidine , a therapeutic drug for Pneumocystis_carinii_pneumonia -LRB- PCP -RRB- in acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- , on specific bindings of -LSB- 3H -RSB- -LRB- + -RRB- -5-methyl-10,11-dihydro-5H - _ dibenzo -LSB- a , d -RSB- cyclohepten-5,11-imine_maleate -LRB- MK-801 -RRB- and -LSB- 3H -RSB- nitrendipine were investigated in crude synaptic membranes -LRB- CSM -RRB- of rat brain .
+In the current study , the expression of B7-H3 in 45 patients with intrahepatic_cholangiocarcinoma and 8 patients with hepatolithiasis was analyzed by immunohistochemistry , which revealed that B7-H3 was not expressed in hepatolithiatic tissues , but positively expressed in 57.8 % -LRB- 26/45 -RRB- of the ICC cases .
+METHODS : Thalidomide was given to 2 patients with EOS -LRB- a 16-year-old girl and an 8-year-old boy -RRB- at an initial dosage of 2 mg/kg/day , and the dosage was increased if necessary .
+METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : Three models were selected : -LRB- 1 -RRB- the Nyx -LRB- nob -RRB- mouse model of complete congenital_stationary_night_blindness , -LRB- 2 -RRB- the oxygen-induced retinopathy -LRB- OIR -RRB- rat model of retinopathy_of_prematurity -LRB- ROP -RRB- , and -LRB- 3 -RRB- the Rs1 knockout -LRB- KO -RRB- mouse model of X-linked_juvenile_retinoschisis .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+Analysis of the products of RT-PCR showed biallelic expression of the H19 gene in 12 testicular_germ_cell_tumors -LRB- patients numbered 6 , 8-13 , 15 , 16 , and 18-20 -RRB- and of the IGF2 gene in 10 testicular_germ_cell_tumors -LRB- patients numbered 1 , 3 , 6 , 8-13 , and 15-20 -RRB- .
+METHODS : We performed a multicenter , randomized , double-blind , placebo-controlled trial to evaluate the efficacy and safety of eprodisate in patients with AA_amyloidosis_and_kidney_involvement .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+A phase 2 , randomized , double-blind , placebo-controlled , dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal_candidiasis .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+We undertook a double-blind , randomized , placebo-controlled , cross-over study to investigate the effects of a single dose of formoterol inhaled via Turbuhaler -LRB- 12 micrograms -RRB- and of albuterol inhaled via Turbuhaler -LRB- 200 micrograms -RRB- on airway responsiveness to AMP and histamine in 16 subjects with mild atopic_asthma .
+The aim of this randomized double-blind , placebo-controlled , parallel-group study was to evaluate the efficacy , safety , and tolerability of pregabalin in combination with oxycodone or placebo , in patients with either postherpetic_neuralgia -LRB- PHN -RRB- or painful_diabetic_neuropathy -LRB- PDN -RRB- .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+A double-blind , randomized , prospective , parallel-group study was conducted to evaluate the efficacy and safety of MTA in the treatment of asthmatic_crisis in children 2 to 6 years of age .
+These in vitro and in vivo data suggest that c-MET may be a potential therapeutic target in ASPS , and cabozantinib may be a particularly useful therapeutic option for patients with ASPS , including those with pazopanib-resistant ASPS .
+AIM : The aim of this study was to evaluate the effectiveness of short-term -LRB- 3 months -RRB- and long-term -LRB- 12-24 months -RRB- treatment with cabergoline in patients with CD .
+BACKGROUND : This randomized , double-blind , placebo-controlled trial was designed to assess the efficacy and safety of topiramate in bulimia_nervosa .
+MATERIALS AND METHODS : Twenty-eight patients with severe VKC were randomly assigned to receive either topical MMC -LRB- 0.01 % -RRB- -LRB- n = 17 -RRB- or distilled water -LRB- n = 11 -RRB- three times daily for a period of two weeks .
+METHODS : SR_49059 , an orally active , non-peptidic vasopressin_V1a_receptor antagonist , was given orally -LRB- 300 mg once daily -RRB- to 20 patients with RP in a single-centre , double-blind , placebo-controlled , randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout .
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