README.md

---
library_name: popV
license: cc-by-4.0
tags:
- biology
- genomics
- single-cell
- anndata_version:0.11.3
- python_version:3.11.11
- popV
- 'tissue: diverse'
---

Popular Vote (popV) model for automated cell type annotation of single-cell RNA-seq data. We provide here pretrained models
for plug-in use in your own analysis.
Follow our [tutorial](https://github.com/YosefLab/popV/blob/main/tabula_sapiens_tutorial.ipynb) to learn how to use the model for cell type annotation.

# Model description

Tabula Sapiens is a benchmark, first-draft human cell atlas of over 1.1M cells from 28 organs of 24 normal human subjects. This work is the product of the Tabula Sapiens Consortium. Taking the organs from the same individual controls for genetic background, age, environment, and epigenetic effects, and allows detailed analysis and comparison of cell types that are shared between tissues.

**Link to CELLxGENE**:
Link to the [data](https://cellxgene.cziscience.com/e/53d208b0-2cfd-4366-9866-c3c6114081bc.cxg/) in the CELLxGENE browser for interactive exploration of the data and download of the source data.

**Training Code URL**:
Not provided by uploader.

# Metrics

We provide here accuracies for each of the experts and the ensemble model. The validation set accuracies are
computed on a 10% random subset of the data that was not used for training.

| Cell Type | N cells |  celltypist |  knn bbknn |  knn harmony |  knn on scvi |  onclass |  scanvi |  svm |  xgboost | Consensus Prediction |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| B cell | 11660 | 0.99 | 0.99 | 0.99 | 0.99 | 0.00 | 0.99 | 0.99 | 0.98 | 0.99 |
| CD4-positive, alpha-beta T cell | 9698 | 0.56 | 0.79 | 0.82 | 0.73 | 0.00 | 0.59 | 0.43 | 0.51 | 0.79 |
| fibroblast | 8490 | 0.79 | 0.80 | 0.94 | 0.70 | 0.00 | 0.64 | 0.70 | 0.66 | 0.89 |
| CD8-positive, alpha-beta T cell | 7669 | 0.73 | 0.78 | 0.81 | 0.74 | 0.00 | 0.74 | 0.58 | 0.61 | 0.80 |
| neutrophil | 6857 | 0.95 | 0.97 | 0.97 | 0.97 | 0.00 | 0.94 | 0.95 | 0.93 | 0.98 |
| macrophage | 6769 | 0.79 | 0.84 | 0.93 | 0.81 | 0.00 | 0.74 | 0.74 | 0.70 | 0.89 |
| stromal cell of ovary | 3561 | 0.95 | 0.94 | 0.91 | 0.68 | 0.00 | 0.39 | 0.96 | 0.92 | 0.98 |
| endothelial cell | 3306 | 0.69 | 0.73 | 0.91 | 0.62 | 0.00 | 0.54 | 0.65 | 0.63 | 0.83 |
| basal cell | 3386 | 0.89 | 0.86 | 0.89 | 0.68 | 0.00 | 0.63 | 0.85 | 0.82 | 0.93 |
| plasma cell | 2769 | 0.98 | 0.98 | 0.97 | 0.97 | 0.00 | 0.98 | 0.98 | 0.97 | 0.99 |
| bladder urothelial cell | 2725 | 0.99 | 0.97 | 0.97 | 0.65 | 0.00 | 0.60 | 0.98 | 0.96 | 0.99 |
| monocyte | 2546 | 0.43 | 0.41 | 0.77 | 0.47 | 0.00 | 0.26 | 0.50 | 0.52 | 0.59 |
| mesenchymal stem cell | 2373 | 0.89 | 0.81 | 0.90 | 0.40 | 0.00 | 0.10 | 0.90 | 0.81 | 0.91 |
| smooth muscle cell | 1899 | 0.72 | 0.69 | 0.88 | 0.69 | 0.00 | 0.64 | 0.73 | 0.72 | 0.81 |
| classical monocyte | 1761 | 0.59 | 0.62 | 0.75 | 0.43 | 0.00 | 0.57 | 0.59 | 0.64 | 0.71 |
| luminal epithelial cell of mammary gland | 1527 | 0.98 | 0.08 | 0.96 | 0.72 | 0.00 | 0.60 | 0.98 | 0.96 | 0.99 |
| capillary endothelial cell | 1503 | 0.69 | 0.65 | 0.88 | 0.53 | 0.00 | 0.55 | 0.67 | 0.65 | 0.78 |
| erythrocyte | 1475 | 0.97 | 0.96 | 0.95 | 0.96 | 0.00 | 0.96 | 0.95 | 0.96 | 0.97 |
| natural killer cell | 1495 | 0.72 | 0.75 | 0.75 | 0.67 | 0.00 | 0.73 | 0.67 | 0.70 | 0.75 |
| enterocyte of epithelium proper of duodenum | 1351 | 0.91 | 0.49 | 0.81 | 0.41 | 0.00 | 0.34 | 0.90 | 0.89 | 0.94 |
| stratified squamous epithelial cell | 1234 | 0.84 | 0.78 | 0.87 | 0.71 | 0.00 | 0.68 | 0.84 | 0.82 | 0.88 |
| acinar cell of salivary gland | 1210 | 0.95 | 0.85 | 0.94 | 0.61 | 0.00 | 0.43 | 0.95 | 0.93 | 0.97 |
| pulmonary alveolar type 2 cell | 1212 | 0.97 | 0.96 | 0.97 | 0.83 | 0.00 | 0.91 | 0.97 | 0.96 | 0.98 |
| conjunctival epithelial cell | 1173 | 0.92 | 0.76 | 0.85 | 0.51 | 0.00 | 0.31 | 0.94 | 0.90 | 0.95 |
| pericyte | 1110 | 0.64 | 0.58 | 0.84 | 0.53 | 0.00 | 0.55 | 0.67 | 0.66 | 0.75 |
| luminal cell of prostate epithelium | 1066 | 0.90 | 0.85 | 0.92 | 0.76 | 0.00 | 0.65 | 0.94 | 0.91 | 0.95 |
| cardiac endothelial cell | 940 | 0.94 | 0.91 | 0.92 | 0.47 | 0.00 | 0.20 | 0.95 | 0.88 | 0.97 |
| naive thymus-derived CD4-positive, alpha-beta T cell | 970 | 0.21 | 0.04 | 0.32 | 0.06 | 0.00 | 0.22 | 0.22 | 0.28 | 0.29 |
| kidney epithelial cell | 954 | 0.99 | 0.89 | 0.94 | 0.52 | 0.00 | 0.02 | 0.99 | 0.98 | 0.99 |
| hepatocyte | 764 | 1.00 | 0.99 | 0.95 | 0.64 | 0.00 | 0.70 | 0.99 | 0.96 | 0.99 |
| blood vessel smooth muscle cell | 630 | 0.73 | 0.49 | 0.89 | 0.42 | 0.00 | 0.21 | 0.89 | 0.76 | 0.91 |
| enterocyte of epithelium proper of ileum | 640 | 0.97 | 0.01 | 0.79 | 0.36 | 0.00 | 0.02 | 0.98 | 0.95 | 0.97 |
| T cell | 645 | 0.47 | 0.22 | 0.57 | 0.08 | 0.00 | 0.24 | 0.39 | 0.38 | 0.56 |
| mast cell | 582 | 0.88 | 0.85 | 0.96 | 0.83 | 0.00 | 0.91 | 0.91 | 0.87 | 0.93 |
| skeletal muscle satellite stem cell | 589 | 0.96 | 0.94 | 0.96 | 0.80 | 0.00 | 0.81 | 0.95 | 0.91 | 0.97 |
| regular atrial cardiac myocyte | 555 | 0.83 | 0.81 | 0.82 | 0.28 | 0.00 | 0.09 | 0.91 | 0.91 | 0.94 |
| pancreatic acinar cell | 560 | 0.95 | 0.26 | 0.93 | 0.55 | 0.00 | 0.45 | 0.98 | 0.96 | 0.98 |
| intermediate monocyte | 535 | 0.38 | 0.13 | 0.55 | 0.20 | 0.00 | 0.20 | 0.35 | 0.44 | 0.51 |
| mature NK T cell | 547 | 0.37 | 0.42 | 0.54 | 0.35 | 0.00 | 0.45 | 0.35 | 0.43 | 0.55 |
| mononuclear phagocyte | 460 | 0.39 | 0.00 | 0.92 | 0.14 | 0.00 | 0.01 | 0.63 | 0.48 | 0.59 |
| fibroblast of breast | 499 | 0.81 | 0.00 | 0.98 | 0.20 | 0.00 | 0.42 | 0.84 | 0.70 | 0.94 |
| vascular associated smooth muscle cell | 478 | 0.66 | 0.06 | 0.76 | 0.22 | 0.00 | 0.39 | 0.59 | 0.61 | 0.69 |
| vein endothelial cell | 461 | 0.42 | 0.15 | 0.74 | 0.23 | 0.00 | 0.32 | 0.46 | 0.43 | 0.59 |
| CD4-positive, alpha-beta thymocyte | 457 | 0.39 | 0.00 | 0.57 | 0.24 | 0.00 | 0.36 | 0.34 | 0.32 | 0.61 |
| enterocyte of epithelium of large intestine | 426 | 0.77 | 0.28 | 0.56 | 0.42 | 0.00 | 0.22 | 0.78 | 0.83 | 0.79 |
| myofibroblast cell | 429 | 0.60 | 0.25 | 0.82 | 0.46 | 0.00 | 0.41 | 0.61 | 0.58 | 0.77 |
| thymic fibroblast type 2 | 439 | 0.57 | 0.00 | 0.70 | 0.15 | 0.00 | 0.12 | 0.68 | 0.55 | 0.63 |
| corneal epithelial cell | 393 | 0.90 | 0.01 | 0.92 | 0.81 | 0.00 | 0.89 | 0.96 | 0.93 | 0.96 |
| spermatid | 412 | 0.96 | 0.00 | 0.96 | 0.83 | 0.00 | 0.97 | 0.98 | 0.96 | 0.98 |
| duct epithelial cell | 356 | 0.83 | 0.59 | 0.85 | 0.56 | 0.00 | 0.48 | 0.86 | 0.77 | 0.89 |
| mesenchymal stem cell of adipose tissue | 344 | 0.26 | 0.01 | 0.65 | 0.38 | 0.00 | 0.22 | 0.29 | 0.33 | 0.52 |
| basal cell of prostate epithelium | 350 | 0.73 | 0.14 | 0.89 | 0.41 | 0.00 | 0.60 | 0.88 | 0.72 | 0.86 |
| endothelial cell of artery | 362 | 0.52 | 0.45 | 0.78 | 0.46 | 0.00 | 0.57 | 0.63 | 0.55 | 0.76 |
| stromal cell | 340 | 0.60 | 0.03 | 0.47 | 0.43 | 0.00 | 0.26 | 0.77 | 0.69 | 0.86 |
| thymic fibroblast type 1 | 333 | 0.29 | 0.01 | 0.84 | 0.22 | 0.00 | 0.04 | 0.66 | 0.43 | 0.49 |
| pulmonary alveolar type 1 cell | 314 | 0.95 | 0.95 | 0.96 | 0.88 | 0.00 | 0.94 | 0.97 | 0.94 | 0.97 |
| spermatocyte | 298 | 0.89 | 0.00 | 0.94 | 0.46 | 0.00 | 0.68 | 0.97 | 0.96 | 0.96 |
| pancreatic ductal cell | 271 | 0.87 | 0.52 | 0.90 | 0.67 | 0.00 | 0.43 | 0.96 | 0.94 | 0.96 |
| regulatory T cell | 279 | 0.07 | 0.01 | 0.26 | 0.08 | 0.00 | 0.22 | 0.30 | 0.34 | 0.35 |
| ventricular cardiac muscle cell | 241 | 0.34 | 0.03 | 0.75 | 0.32 | 0.00 | 0.46 | 0.82 | 0.81 | 0.86 |
| endothelial cell of lymphatic vessel | 250 | 0.69 | 0.57 | 0.87 | 0.57 | 0.00 | 0.60 | 0.60 | 0.62 | 0.72 |
| hematopoietic precursor cell | 221 | 0.63 | 0.68 | 0.73 | 0.61 | 0.00 | 0.46 | 0.59 | 0.59 | 0.76 |
| retinal blood vessel endothelial cell | 221 | 0.22 | 0.00 | 0.77 | 0.17 | 0.00 | 0.00 | 0.61 | 0.50 | 0.56 |
| small intestine goblet cell | 220 | 0.85 | 0.66 | 0.90 | 0.71 | 0.00 | 0.47 | 0.90 | 0.85 | 0.90 |
| gamma-delta T cell | 168 | 0.20 | 0.15 | 0.66 | 0.11 | 0.00 | 0.37 | 0.62 | 0.45 | 0.65 |
| fibroblast of cardiac tissue | 183 | 0.94 | 0.49 | 0.93 | 0.07 | 0.00 | 0.21 | 0.71 | 0.64 | 0.93 |
| paneth cell of epithelium of small intestine | 178 | 0.51 | 0.49 | 0.71 | 0.17 | 0.00 | 0.31 | 0.59 | 0.61 | 0.77 |
| club cell | 162 | 0.81 | 0.75 | 0.85 | 0.57 | 0.00 | 0.71 | 0.78 | 0.70 | 0.86 |
| intestinal crypt stem cell of colon | 171 | 0.76 | 0.61 | 0.55 | 0.36 | 0.00 | 0.16 | 0.85 | 0.80 | 0.85 |
| progenitor cell of mammary luminal epithelium | 174 | 0.99 | 0.00 | 0.96 | 0.94 | 0.00 | 0.92 | 0.96 | 0.93 | 0.99 |
| epithelial cell | 173 | 0.91 | 0.67 | 0.94 | 0.44 | 0.00 | 0.45 | 0.92 | 0.90 | 0.91 |
| basophil | 162 | 0.42 | 0.07 | 0.94 | 0.35 | 0.00 | 0.77 | 0.77 | 0.69 | 0.83 |
| large intestine goblet cell | 142 | 0.88 | 0.71 | 0.85 | 0.51 | 0.00 | 0.45 | 0.94 | 0.86 | 0.91 |
| eye photoreceptor cell | 143 | 0.88 | 0.88 | 0.92 | 0.87 | 0.00 | 0.90 | 0.97 | 0.94 | 0.95 |
| epithelial cell of uterus | 150 | 0.93 | 0.43 | 0.91 | 0.30 | 0.00 | 0.50 | 0.88 | 0.82 | 0.95 |
| enterocyte of epithelium proper of small intestine | 136 | 0.38 | 0.00 | 0.59 | 0.29 | 0.00 | 0.01 | 0.60 | 0.55 | 0.72 |
| tissue-resident macrophage | 118 | 0.60 | 0.00 | 0.78 | 0.32 | 0.00 | 0.20 | 0.48 | 0.46 | 0.71 |
| acinar cell | 141 | 0.80 | 0.60 | 0.83 | 0.75 | 0.00 | 0.79 | 0.89 | 0.88 | 0.90 |
| non-classical monocyte | 136 | 0.29 | 0.28 | 0.27 | 0.07 | 0.00 | 0.22 | 0.27 | 0.34 | 0.43 |
| lung ciliated cell | 131 | 0.78 | 0.58 | 0.98 | 0.74 | 0.00 | 0.91 | 0.96 | 0.89 | 0.96 |
| activated CD8-positive, alpha-beta T cell | 109 | 0.35 | 0.00 | 0.72 | 0.02 | 0.00 | 0.04 | 0.29 | 0.28 | 0.38 |
| alveolar adventitial fibroblast | 111 | 0.72 | 0.05 | 0.89 | 0.21 | 0.00 | 0.57 | 0.54 | 0.73 | 0.85 |
| naive thymus-derived CD8-positive, alpha-beta T cell | 118 | 0.15 | 0.00 | 0.39 | 0.07 | 0.00 | 0.15 | 0.14 | 0.12 | 0.33 |
| adventitial cell | 106 | 0.13 | 0.00 | 0.74 | 0.12 | 0.00 | 0.31 | 0.28 | 0.29 | 0.62 |
| respiratory goblet cell | 105 | 0.48 | 0.57 | 0.81 | 0.47 | 0.00 | 0.55 | 0.60 | 0.58 | 0.77 |
| theca cell | 101 | 0.63 | 0.08 | 0.80 | 0.34 | 0.00 | 0.70 | 0.77 | 0.58 | 0.81 |
| myeloid leukocyte | 93 | 0.17 | 0.00 | 0.73 | 0.14 | 0.00 | 0.19 | 0.23 | 0.14 | 0.54 |
| keratocyte | 103 | 0.30 | 0.00 | 0.56 | 0.06 | 0.00 | 0.14 | 0.52 | 0.38 | 0.35 |
| enteroglial cell | 89 | 0.84 | 0.69 | 0.94 | 0.80 | 0.00 | 0.75 | 0.96 | 0.83 | 0.86 |
| erythroid progenitor cell | 92 | 0.59 | 0.59 | 0.69 | 0.61 | 0.00 | 0.52 | 0.65 | 0.65 | 0.70 |
| innate lymphoid cell | 90 | 0.17 | 0.18 | 0.34 | 0.31 | 0.00 | 0.22 | 0.19 | 0.19 | 0.37 |
| myometrial cell | 86 | 0.78 | 0.00 | 0.78 | 0.15 | 0.00 | 0.21 | 0.64 | 0.53 | 0.80 |
| endothelial cell of vascular tree | 90 | 0.45 | 0.15 | 0.54 | 0.54 | 0.00 | 0.21 | 0.50 | 0.46 | 0.68 |
| hematopoietic stem cell | 91 | 0.74 | 0.65 | 0.77 | 0.72 | 0.00 | 0.64 | 0.79 | 0.79 | 0.85 |
| salivary gland cell | 88 | 0.54 | 0.00 | 0.89 | 0.57 | 0.00 | 0.67 | 0.54 | 0.58 | 0.88 |
| granulocyte | 76 | 0.23 | 0.03 | 0.50 | 0.35 | 0.00 | 0.15 | 0.24 | 0.19 | 0.47 |
| CD8-positive, alpha-beta thymocyte | 72 | 0.24 | 0.00 | 0.39 | 0.17 | 0.00 | 0.18 | 0.24 | 0.25 | 0.44 |
| ciliated columnar cell of tracheobronchial tree | 61 | 0.19 | 0.28 | 0.96 | 0.52 | 0.00 | 0.78 | 0.90 | 0.83 | 0.96 |
| intrahepatic cholangiocyte | 49 | 0.99 | 0.05 | 0.95 | 0.27 | 0.00 | 0.55 | 0.97 | 0.87 | 0.99 |
| mural cell | 73 | 0.35 | 0.10 | 0.86 | 0.13 | 0.00 | 0.31 | 0.61 | 0.54 | 0.78 |
| intestinal crypt stem cell of small intestine | 56 | 0.24 | 0.27 | 0.32 | 0.16 | 0.00 | 0.04 | 0.34 | 0.39 | 0.47 |
| activated CD4-positive, alpha-beta T cell | 77 | 0.04 | 0.00 | 0.32 | 0.00 | 0.00 | 0.14 | 0.13 | 0.13 | 0.28 |
| myeloid dendritic cell | 46 | 0.14 | 0.15 | 0.41 | 0.22 | 0.00 | 0.11 | 0.16 | 0.12 | 0.23 |
| Mueller cell | 47 | 0.54 | 0.34 | 0.59 | 0.64 | 0.00 | 0.72 | 0.88 | 0.72 | 0.82 |
| fast muscle cell | 52 | 0.71 | 0.56 | 0.93 | 0.74 | 0.00 | 0.88 | 0.81 | 0.81 | 0.93 |
| platelet | 37 | 0.91 | 0.90 | 0.95 | 0.83 | 0.00 | 0.70 | 0.90 | 0.69 | 0.93 |
| myoepithelial cell | 41 | 0.76 | 0.41 | 0.72 | 0.43 | 0.00 | 0.38 | 0.62 | 0.38 | 0.89 |
| common myeloid progenitor | 53 | 0.54 | 0.46 | 0.76 | 0.30 | 0.00 | 0.38 | 0.62 | 0.68 | 0.66 |
| thymocyte | 42 | 0.00 | 0.00 | 0.33 | 0.33 | 0.00 | 0.39 | 0.33 | 0.21 | 0.67 |
| intestinal tuft cell | 26 | 0.68 | 0.58 | 0.92 | 0.58 | 0.00 | 0.59 | 0.96 | 0.81 | 0.88 |
| pancreatic stellate cell | 44 | 0.00 | 0.00 | 0.88 | 0.33 | 0.00 | 0.00 | 0.54 | 0.31 | 0.78 |
| tendon cell | 35 | 0.43 | 0.00 | 0.52 | 0.44 | 0.00 | 0.30 | 0.45 | 0.21 | 0.67 |
| microglial cell | 41 | 0.07 | 0.00 | 0.53 | 0.12 | 0.00 | 0.15 | 0.20 | 0.15 | 0.34 |
| muscle cell | 47 | 0.71 | 0.00 | 0.95 | 0.74 | 0.00 | 0.91 | 0.80 | 0.84 | 0.95 |
| enterocyte of epithelium proper of jejunum | 52 | 0.00 | 0.00 | 0.20 | 0.27 | 0.00 | 0.11 | 0.55 | 0.37 | 0.63 |
| mesothelial cell | 34 | 0.67 | 0.65 | 0.86 | 0.75 | 0.00 | 0.41 | 0.44 | 0.72 | 0.72 |
| colon endothelial cell | 43 | 0.05 | 0.05 | 0.68 | 0.07 | 0.00 | 0.21 | 0.26 | 0.33 | 0.46 |
| colon macrophage | 35 | 0.19 | 0.00 | 0.76 | 0.04 | 0.00 | 0.03 | 0.24 | 0.18 | 0.57 |
| serous cell of epithelium of trachea | 27 | 0.37 | 0.00 | 0.79 | 0.25 | 0.00 | 0.10 | 0.38 | 0.39 | 0.76 |
| ciliated epithelial cell | 34 | 0.90 | 0.00 | 0.96 | 0.48 | 0.00 | 0.85 | 0.96 | 0.86 | 0.94 |
| Schwann cell | 28 | 0.73 | 0.56 | 0.60 | 0.42 | 0.00 | 0.46 | 0.61 | 0.55 | 0.74 |
| supporting cell of vestibular epithelium | 31 | 0.86 | 0.12 | 0.52 | 0.64 | 0.00 | 0.36 | 0.98 | 0.77 | 0.94 |
| mucus secreting cell | 24 | 0.57 | 0.11 | 0.78 | 0.21 | 0.00 | 0.22 | 0.62 | 0.55 | 0.78 |
| enteroendocrine cell of small intestine | 25 | 0.64 | 0.10 | 0.78 | 0.55 | 0.00 | 0.67 | 0.86 | 0.68 | 0.78 |
| ovarian surface epithelial cell | 19 | 0.55 | 0.33 | 0.80 | 0.60 | 0.00 | 0.17 | 0.84 | 0.61 | 0.89 |
| transit amplifying cell of colon | 23 | 0.56 | 0.35 | 0.46 | 0.13 | 0.00 | 0.06 | 0.53 | 0.42 | 0.67 |
| glandular epithelial cell | 26 | 0.67 | 0.11 | 0.67 | 0.21 | 0.00 | 0.59 | 0.98 | 0.62 | 0.89 |
| melanocyte | 24 | 0.75 | 0.51 | 0.70 | 0.36 | 0.00 | 0.53 | 0.81 | 0.57 | 0.94 |
| tracheal goblet cell | 20 | 0.00 | 0.19 | 0.58 | 0.67 | 0.00 | 0.40 | 0.75 | 0.63 | 0.74 |
| hepatic stellate cell | 26 | 0.36 | 0.00 | 0.71 | 0.13 | 0.00 | 0.15 | 0.54 | 0.38 | 0.69 |
| bronchial smooth muscle cell | 26 | 0.00 | 0.00 | 0.56 | 0.11 | 0.00 | 0.33 | 0.35 | 0.33 | 0.53 |
| paneth cell of colon | 21 | 0.58 | 0.29 | 0.50 | 0.41 | 0.00 | 0.18 | 0.77 | 0.34 | 0.88 |
| tongue muscle cell | 18 | 0.50 | 0.00 | 0.81 | 0.31 | 0.00 | 0.36 | 0.58 | 0.32 | 0.77 |
| leukocyte | 28 | 0.16 | 0.07 | 0.19 | 0.00 | 0.00 | 0.00 | 0.14 | 0.11 | 0.21 |
| tuft cell of colon | 32 | 0.00 | 0.00 | 0.72 | 0.37 | 0.00 | 0.70 | 0.89 | 0.83 | 0.85 |
| slow muscle cell | 19 | 0.70 | 0.25 | 0.73 | 0.40 | 0.00 | 0.64 | 0.76 | 0.73 | 0.80 |
| ionocyte | 13 | 0.52 | 0.18 | 0.76 | 0.46 | 0.00 | 0.06 | 0.81 | 0.67 | 0.86 |
| connective tissue cell | 20 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.56 | 0.24 | 0.69 |
| neuro-medullary thymic epithelial cell | 12 | 0.34 | 0.35 | 0.73 | 0.36 | 0.00 | 0.25 | 0.38 | 0.35 | 0.46 |
| sebum secreting cell | 18 | 0.00 | 0.02 | 0.77 | 0.16 | 0.00 | 0.12 | 0.81 | 0.58 | 0.83 |
| endothelial cell of arteriole | 11 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 | 0.26 | 0.42 | 0.32 | 0.62 |
| male germ cell | 12 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.21 | 0.96 | 0.81 | 0.96 |
| type B pancreatic cell | 10 | 0.80 | 0.00 | 0.84 | 0.86 | 0.00 | 0.74 | 0.95 | 0.86 | 0.95 |
| hematopoietic cell | 10 | 0.00 | 0.00 | 0.53 | 0.00 | 0.00 | 0.18 | 0.62 | 0.42 | 0.86 |
| plasmacytoid dendritic cell | 5 | 0.13 | 0.29 | 0.33 | 0.22 | 0.00 | 0.06 | 0.35 | 0.17 | 0.35 |
| neuron | 4 | 0.00 | 0.00 | 0.89 | 0.21 | 0.00 | 0.29 | 0.44 | 0.46 | 0.89 |
| myeloid cell | 5 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.22 | 0.10 | 0.25 |
| myo-medullary thymic epithelial cell | 3 | 0.33 | 0.00 | 0.80 | 0.33 | 0.00 | 0.44 | 0.57 | 0.40 | 0.67 |
| Langerhans cell | 10 | 0.00 | 0.00 | 0.67 | 0.25 | 0.00 | 0.42 | 0.32 | 0.34 | 0.63 |
| interstitial cell of Cajal | 7 | 0.00 | 0.00 | 1.00 | 0.15 | 0.00 | 0.00 | 0.70 | 0.56 | 0.86 |
| retinal pigment epithelial cell | 6 | 0.92 | 0.00 | 0.50 | 0.80 | 0.00 | 0.92 | 1.00 | 0.92 | 1.00 |
| peritubular myoid cell | 8 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.35 | 0.35 | 0.43 |
| spermatogonium | 10 | 0.00 | 0.00 | 0.50 | 0.00 | 0.00 | 0.25 | 0.82 | 0.86 | 0.75 |
| retinal bipolar neuron | 10 | 0.00 | 0.18 | 0.46 | 0.40 | 0.00 | 0.26 | 0.76 | 0.67 | 0.67 |
| endothelial cell of venule | 7 | 0.00 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.73 | 0.30 | 0.00 |
| vestibular dark cell | 5 | 0.00 | 0.00 | 0.33 | 0.20 | 0.00 | 0.09 | 1.00 | 0.73 | 0.80 |
| pancreatic A cell | 2 | 0.67 | 0.00 | 0.67 | 1.00 | 0.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| type L enteroendocrine cell | 4 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.57 | 1.00 | 0.44 | 0.40 |
| medullary thymic epithelial cell | 3 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.03 | 1.00 | 0.67 | 0.50 |
| adipocyte | 2 | 0.00 | 0.00 | 0.50 | 0.00 | 0.00 | 0.20 | 0.22 | 0.12 | 0.29 |
| transit amplifying cell of small intestine | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| taste receptor cell | 3 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.07 | 0.50 | 0.09 | 0.80 |
| enterochromaffin-like cell | 2 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 1.00 | 0.40 | 0.00 |
| enteroendocrine cell | 4 | 0.00 | 0.33 | 1.00 | 0.57 | 0.00 | 0.55 | 0.89 | 0.44 | 0.89 |
| pulmonary ionocyte | 2 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 | 0.21 | 1.00 | 1.00 | 1.00 |
| glial cell | 1 | 0.00 | 0.00 | 0.50 | 0.00 | 0.00 | 0.10 | 0.40 | 0.15 | 0.67 |
| oocyte | 5 | 0.00 | 0.04 | 0.89 | 0.89 | 0.00 | 0.71 | 1.00 | 1.00 | 1.00 |
| serous cell of epithelium of bronchus | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| radial glial cell | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Leydig cell | 3 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.33 | 0.00 |
| pancreatic D cell | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| T follicular helper cell | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| retina horizontal cell | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| erythroid lineage cell | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| pancreatic PP cell | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| epithelial fate stem cell | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| mesenchymal cell | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |

The train accuracies are computed on the training data.

| Cell Type | N cells |  celltypist |  knn bbknn |  knn harmony |  knn on scvi |  onclass |  scanvi |  svm |  xgboost | Consensus Prediction |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| B cell | 102833 | 0.99 | 0.99 | 0.99 | 0.99 | 0.00 | 0.99 | 0.99 | 0.98 | 0.99 |
| CD4-positive, alpha-beta T cell | 87430 | 0.57 | 0.78 | 0.87 | 0.83 | 0.00 | 0.57 | 0.45 | 0.52 | 0.82 |
| fibroblast | 74840 | 0.79 | 0.74 | 0.97 | 0.85 | 0.00 | 0.86 | 0.70 | 0.66 | 0.93 |
| CD8-positive, alpha-beta T cell | 68607 | 0.73 | 0.77 | 0.87 | 0.82 | 0.00 | 0.72 | 0.59 | 0.62 | 0.82 |
| neutrophil | 62682 | 0.95 | 0.97 | 0.98 | 0.98 | 0.00 | 0.94 | 0.95 | 0.93 | 0.98 |
| macrophage | 62296 | 0.79 | 0.83 | 0.95 | 0.87 | 0.00 | 0.77 | 0.75 | 0.70 | 0.91 |
| stromal cell of ovary | 31442 | 0.95 | 0.67 | 0.94 | 0.89 | 0.00 | 0.95 | 0.96 | 0.92 | 0.99 |
| endothelial cell | 30391 | 0.70 | 0.69 | 0.96 | 0.82 | 0.00 | 0.81 | 0.66 | 0.65 | 0.91 |
| basal cell | 30140 | 0.88 | 0.80 | 0.94 | 0.81 | 0.00 | 0.84 | 0.85 | 0.83 | 0.94 |
| plasma cell | 24580 | 0.98 | 0.97 | 0.98 | 0.97 | 0.00 | 0.97 | 0.98 | 0.97 | 0.99 |
| bladder urothelial cell | 24516 | 0.98 | 0.96 | 0.98 | 0.78 | 0.00 | 0.95 | 0.98 | 0.97 | 0.99 |
| monocyte | 23207 | 0.44 | 0.31 | 0.86 | 0.73 | 0.00 | 0.59 | 0.51 | 0.53 | 0.72 |
| mesenchymal stem cell | 21124 | 0.89 | 0.73 | 0.95 | 0.72 | 0.00 | 0.94 | 0.91 | 0.82 | 0.95 |
| smooth muscle cell | 16525 | 0.73 | 0.64 | 0.93 | 0.85 | 0.00 | 0.84 | 0.75 | 0.75 | 0.88 |
| classical monocyte | 16439 | 0.58 | 0.55 | 0.84 | 0.74 | 0.00 | 0.71 | 0.59 | 0.65 | 0.77 |
| luminal epithelial cell of mammary gland | 13905 | 0.98 | 0.00 | 0.98 | 0.85 | 0.00 | 0.96 | 0.98 | 0.96 | 0.99 |
| capillary endothelial cell | 13793 | 0.70 | 0.54 | 0.93 | 0.78 | 0.00 | 0.76 | 0.69 | 0.68 | 0.85 |
| erythrocyte | 13136 | 0.97 | 0.96 | 0.98 | 0.98 | 0.00 | 0.97 | 0.96 | 0.96 | 0.97 |
| natural killer cell | 12736 | 0.72 | 0.73 | 0.83 | 0.80 | 0.00 | 0.72 | 0.68 | 0.70 | 0.77 |
| enterocyte of epithelium proper of duodenum | 12144 | 0.91 | 0.00 | 0.88 | 0.75 | 0.00 | 0.94 | 0.91 | 0.89 | 0.96 |
| stratified squamous epithelial cell | 11080 | 0.84 | 0.72 | 0.93 | 0.83 | 0.00 | 0.83 | 0.85 | 0.82 | 0.90 |
| acinar cell of salivary gland | 11027 | 0.95 | 0.74 | 0.97 | 0.80 | 0.00 | 0.95 | 0.95 | 0.93 | 0.98 |
| pulmonary alveolar type 2 cell | 10382 | 0.97 | 0.96 | 0.99 | 0.89 | 0.00 | 0.96 | 0.97 | 0.96 | 0.98 |
| conjunctival epithelial cell | 9912 | 0.91 | 0.70 | 0.91 | 0.71 | 0.00 | 0.91 | 0.94 | 0.90 | 0.96 |
| pericyte | 9774 | 0.64 | 0.49 | 0.90 | 0.77 | 0.00 | 0.72 | 0.69 | 0.67 | 0.81 |
| luminal cell of prostate epithelium | 9586 | 0.91 | 0.68 | 0.96 | 0.86 | 0.00 | 0.93 | 0.94 | 0.92 | 0.95 |
| cardiac endothelial cell | 9147 | 0.94 | 0.80 | 0.98 | 0.83 | 0.00 | 0.97 | 0.95 | 0.88 | 0.98 |
| naive thymus-derived CD4-positive, alpha-beta T cell | 8856 | 0.21 | 0.02 | 0.51 | 0.32 | 0.00 | 0.28 | 0.24 | 0.30 | 0.39 |
| kidney epithelial cell | 8324 | 0.98 | 0.22 | 0.97 | 0.79 | 0.00 | 0.99 | 0.99 | 0.98 | 0.99 |
| hepatocyte | 6650 | 1.00 | 0.98 | 0.98 | 0.89 | 0.00 | 0.97 | 0.99 | 0.98 | 1.00 |
| blood vessel smooth muscle cell | 6012 | 0.73 | 0.20 | 0.95 | 0.87 | 0.00 | 0.94 | 0.90 | 0.79 | 0.95 |
| enterocyte of epithelium proper of ileum | 5837 | 0.97 | 0.00 | 0.86 | 0.67 | 0.00 | 0.96 | 0.98 | 0.96 | 0.98 |
| T cell | 5644 | 0.47 | 0.17 | 0.70 | 0.41 | 0.00 | 0.45 | 0.40 | 0.38 | 0.64 |
| mast cell | 5639 | 0.87 | 0.84 | 0.97 | 0.94 | 0.00 | 0.95 | 0.92 | 0.88 | 0.95 |
| skeletal muscle satellite stem cell | 5579 | 0.95 | 0.92 | 0.98 | 0.92 | 0.00 | 0.96 | 0.95 | 0.91 | 0.97 |
| regular atrial cardiac myocyte | 5261 | 0.82 | 0.62 | 0.91 | 0.75 | 0.00 | 0.96 | 0.91 | 0.91 | 0.95 |
| pancreatic acinar cell | 4921 | 0.95 | 0.01 | 0.97 | 0.83 | 0.00 | 0.91 | 0.98 | 0.96 | 0.99 |
| intermediate monocyte | 4943 | 0.38 | 0.10 | 0.71 | 0.53 | 0.00 | 0.27 | 0.38 | 0.46 | 0.57 |
| mature NK T cell | 4847 | 0.38 | 0.42 | 0.69 | 0.61 | 0.00 | 0.51 | 0.37 | 0.46 | 0.63 |
| mononuclear phagocyte | 4876 | 0.42 | 0.00 | 0.96 | 0.57 | 0.00 | 0.90 | 0.68 | 0.53 | 0.91 |
| fibroblast of breast | 4771 | 0.81 | 0.00 | 0.99 | 0.67 | 0.00 | 0.82 | 0.85 | 0.71 | 0.97 |
| vascular associated smooth muscle cell | 4541 | 0.68 | 0.02 | 0.86 | 0.67 | 0.00 | 0.76 | 0.65 | 0.65 | 0.79 |
| vein endothelial cell | 4236 | 0.42 | 0.09 | 0.87 | 0.60 | 0.00 | 0.55 | 0.50 | 0.49 | 0.72 |
| CD4-positive, alpha-beta thymocyte | 4228 | 0.39 | 0.00 | 0.75 | 0.58 | 0.00 | 0.67 | 0.38 | 0.35 | 0.72 |
| enterocyte of epithelium of large intestine | 4141 | 0.78 | 0.24 | 0.75 | 0.71 | 0.00 | 0.83 | 0.80 | 0.86 | 0.85 |
| myofibroblast cell | 4007 | 0.64 | 0.14 | 0.91 | 0.76 | 0.00 | 0.71 | 0.63 | 0.61 | 0.86 |
| thymic fibroblast type 2 | 3766 | 0.58 | 0.00 | 0.86 | 0.52 | 0.00 | 0.86 | 0.67 | 0.56 | 0.90 |
| corneal epithelial cell | 3792 | 0.90 | 0.00 | 0.95 | 0.89 | 0.00 | 0.94 | 0.96 | 0.92 | 0.96 |
| spermatid | 3597 | 0.96 | 0.00 | 0.98 | 0.98 | 0.00 | 0.98 | 0.99 | 0.96 | 0.99 |
| duct epithelial cell | 3533 | 0.81 | 0.38 | 0.92 | 0.74 | 0.00 | 0.86 | 0.86 | 0.79 | 0.91 |
| mesenchymal stem cell of adipose tissue | 3433 | 0.28 | 0.00 | 0.75 | 0.58 | 0.00 | 0.48 | 0.32 | 0.37 | 0.55 |
| basal cell of prostate epithelium | 3145 | 0.73 | 0.01 | 0.93 | 0.77 | 0.00 | 0.83 | 0.88 | 0.75 | 0.88 |
| endothelial cell of artery | 3109 | 0.47 | 0.28 | 0.84 | 0.66 | 0.00 | 0.69 | 0.63 | 0.55 | 0.79 |
| stromal cell | 3118 | 0.61 | 0.01 | 0.70 | 0.58 | 0.00 | 0.89 | 0.79 | 0.70 | 0.93 |
| thymic fibroblast type 1 | 2937 | 0.30 | 0.00 | 0.91 | 0.55 | 0.00 | 0.86 | 0.68 | 0.48 | 0.87 |
| pulmonary alveolar type 1 cell | 2802 | 0.96 | 0.93 | 0.98 | 0.93 | 0.00 | 0.95 | 0.98 | 0.94 | 0.98 |
| spermatocyte | 2772 | 0.92 | 0.00 | 0.97 | 0.93 | 0.00 | 0.96 | 0.98 | 0.96 | 0.98 |
| pancreatic ductal cell | 2448 | 0.89 | 0.13 | 0.95 | 0.83 | 0.00 | 0.87 | 0.96 | 0.94 | 0.97 |
| regulatory T cell | 2370 | 0.10 | 0.00 | 0.41 | 0.32 | 0.00 | 0.27 | 0.33 | 0.34 | 0.49 |
| ventricular cardiac muscle cell | 2358 | 0.30 | 0.00 | 0.81 | 0.67 | 0.00 | 0.96 | 0.83 | 0.84 | 0.88 |
| endothelial cell of lymphatic vessel | 2188 | 0.66 | 0.46 | 0.94 | 0.76 | 0.00 | 0.76 | 0.63 | 0.64 | 0.80 |
| hematopoietic precursor cell | 1919 | 0.63 | 0.65 | 0.84 | 0.78 | 0.00 | 0.46 | 0.60 | 0.61 | 0.78 |
| retinal blood vessel endothelial cell | 1866 | 0.23 | 0.00 | 0.92 | 0.47 | 0.00 | 0.96 | 0.63 | 0.54 | 0.91 |
| small intestine goblet cell | 1824 | 0.87 | 0.52 | 0.93 | 0.85 | 0.00 | 0.87 | 0.94 | 0.90 | 0.95 |
| gamma-delta T cell | 1809 | 0.20 | 0.11 | 0.78 | 0.38 | 0.00 | 0.56 | 0.67 | 0.49 | 0.79 |
| fibroblast of cardiac tissue | 1764 | 0.95 | 0.18 | 0.99 | 0.54 | 0.00 | 0.85 | 0.74 | 0.68 | 0.98 |
| paneth cell of epithelium of small intestine | 1675 | 0.48 | 0.41 | 0.79 | 0.58 | 0.00 | 0.68 | 0.69 | 0.74 | 0.83 |
| club cell | 1585 | 0.82 | 0.68 | 0.91 | 0.70 | 0.00 | 0.76 | 0.80 | 0.74 | 0.89 |
| intestinal crypt stem cell of colon | 1561 | 0.74 | 0.46 | 0.80 | 0.62 | 0.00 | 0.76 | 0.87 | 0.85 | 0.92 |
| progenitor cell of mammary luminal epithelium | 1520 | 0.98 | 0.00 | 0.99 | 0.97 | 0.00 | 0.94 | 0.96 | 0.93 | 0.99 |
| epithelial cell | 1502 | 0.90 | 0.29 | 0.98 | 0.73 | 0.00 | 0.90 | 0.92 | 0.92 | 0.95 |
| basophil | 1507 | 0.44 | 0.01 | 0.96 | 0.85 | 0.00 | 0.86 | 0.80 | 0.69 | 0.92 |
| large intestine goblet cell | 1415 | 0.88 | 0.15 | 0.93 | 0.77 | 0.00 | 0.77 | 0.94 | 0.89 | 0.94 |
| eye photoreceptor cell | 1385 | 0.90 | 0.90 | 0.96 | 0.94 | 0.00 | 0.96 | 0.98 | 0.97 | 0.97 |
| epithelial cell of uterus | 1267 | 0.93 | 0.23 | 0.98 | 0.65 | 0.00 | 0.90 | 0.92 | 0.86 | 0.98 |
| enterocyte of epithelium proper of small intestine | 1279 | 0.37 | 0.00 | 0.76 | 0.58 | 0.00 | 0.79 | 0.62 | 0.67 | 0.83 |
| tissue-resident macrophage | 1237 | 0.60 | 0.00 | 0.85 | 0.64 | 0.00 | 0.47 | 0.51 | 0.48 | 0.72 |
| acinar cell | 1204 | 0.82 | 0.31 | 0.97 | 0.88 | 0.00 | 0.89 | 0.92 | 0.89 | 0.93 |
| non-classical monocyte | 1148 | 0.35 | 0.30 | 0.55 | 0.37 | 0.00 | 0.24 | 0.35 | 0.37 | 0.60 |
| lung ciliated cell | 1078 | 0.74 | 0.14 | 0.98 | 0.91 | 0.00 | 0.97 | 0.95 | 0.92 | 0.98 |
| activated CD8-positive, alpha-beta T cell | 1038 | 0.38 | 0.00 | 0.87 | 0.45 | 0.00 | 0.58 | 0.33 | 0.32 | 0.71 |
| alveolar adventitial fibroblast | 1002 | 0.76 | 0.01 | 0.94 | 0.61 | 0.00 | 0.64 | 0.61 | 0.75 | 0.95 |
| naive thymus-derived CD8-positive, alpha-beta T cell | 938 | 0.14 | 0.00 | 0.61 | 0.40 | 0.00 | 0.19 | 0.18 | 0.14 | 0.45 |
| adventitial cell | 939 | 0.16 | 0.00 | 0.89 | 0.55 | 0.00 | 0.64 | 0.32 | 0.35 | 0.83 |
| respiratory goblet cell | 935 | 0.53 | 0.39 | 0.90 | 0.73 | 0.00 | 0.59 | 0.64 | 0.66 | 0.85 |
| theca cell | 937 | 0.66 | 0.00 | 0.87 | 0.74 | 0.00 | 0.62 | 0.79 | 0.61 | 0.89 |
| myeloid leukocyte | 909 | 0.14 | 0.00 | 0.84 | 0.45 | 0.00 | 0.68 | 0.31 | 0.21 | 0.77 |
| keratocyte | 896 | 0.36 | 0.00 | 0.77 | 0.31 | 0.00 | 0.53 | 0.54 | 0.39 | 0.78 |
| enteroglial cell | 901 | 0.83 | 0.53 | 0.97 | 0.91 | 0.00 | 0.83 | 0.91 | 0.81 | 0.89 |
| erythroid progenitor cell | 879 | 0.61 | 0.56 | 0.84 | 0.82 | 0.00 | 0.74 | 0.77 | 0.76 | 0.78 |
| innate lymphoid cell | 874 | 0.18 | 0.10 | 0.57 | 0.46 | 0.00 | 0.55 | 0.24 | 0.25 | 0.50 |
| myometrial cell | 831 | 0.82 | 0.00 | 0.88 | 0.67 | 0.00 | 0.79 | 0.68 | 0.62 | 0.89 |
| endothelial cell of vascular tree | 785 | 0.43 | 0.01 | 0.81 | 0.62 | 0.00 | 0.66 | 0.60 | 0.50 | 0.79 |
| hematopoietic stem cell | 767 | 0.71 | 0.52 | 0.85 | 0.80 | 0.00 | 0.74 | 0.87 | 0.83 | 0.87 |
| salivary gland cell | 762 | 0.55 | 0.00 | 0.92 | 0.72 | 0.00 | 0.81 | 0.56 | 0.63 | 0.91 |
| granulocyte | 693 | 0.23 | 0.00 | 0.70 | 0.66 | 0.00 | 0.23 | 0.28 | 0.22 | 0.58 |
| CD8-positive, alpha-beta thymocyte | 659 | 0.23 | 0.00 | 0.58 | 0.45 | 0.00 | 0.55 | 0.32 | 0.32 | 0.77 |
| ciliated columnar cell of tracheobronchial tree | 652 | 0.26 | 0.07 | 0.97 | 0.86 | 0.00 | 0.94 | 0.94 | 0.88 | 0.98 |
| intrahepatic cholangiocyte | 616 | 0.97 | 0.02 | 0.97 | 0.82 | 0.00 | 0.92 | 0.97 | 0.91 | 0.99 |
| mural cell | 545 | 0.32 | 0.07 | 0.95 | 0.62 | 0.00 | 0.65 | 0.65 | 0.57 | 0.96 |
| intestinal crypt stem cell of small intestine | 531 | 0.24 | 0.18 | 0.42 | 0.36 | 0.00 | 0.35 | 0.50 | 0.55 | 0.59 |
| activated CD4-positive, alpha-beta T cell | 495 | 0.04 | 0.00 | 0.55 | 0.30 | 0.00 | 0.16 | 0.14 | 0.13 | 0.32 |
| myeloid dendritic cell | 525 | 0.13 | 0.04 | 0.59 | 0.44 | 0.00 | 0.19 | 0.24 | 0.20 | 0.33 |
| Mueller cell | 459 | 0.64 | 0.30 | 0.84 | 0.79 | 0.00 | 0.86 | 0.95 | 0.83 | 0.91 |
| fast muscle cell | 443 | 0.69 | 0.49 | 0.94 | 0.87 | 0.00 | 0.92 | 0.80 | 0.89 | 0.94 |
| platelet | 457 | 0.90 | 0.89 | 0.96 | 0.93 | 0.00 | 0.78 | 0.94 | 0.78 | 0.96 |
| myoepithelial cell | 445 | 0.72 | 0.17 | 0.91 | 0.77 | 0.00 | 0.64 | 0.63 | 0.45 | 0.92 |
| common myeloid progenitor | 403 | 0.60 | 0.27 | 0.84 | 0.76 | 0.00 | 0.65 | 0.88 | 0.80 | 0.88 |
| thymocyte | 413 | 0.00 | 0.00 | 0.65 | 0.53 | 0.00 | 0.53 | 0.45 | 0.32 | 0.88 |
| intestinal tuft cell | 422 | 0.85 | 0.79 | 0.97 | 0.87 | 0.00 | 0.96 | 0.97 | 0.97 | 0.97 |
| pancreatic stellate cell | 393 | 0.00 | 0.00 | 0.97 | 0.63 | 0.00 | 0.62 | 0.57 | 0.40 | 0.87 |
| tendon cell | 385 | 0.63 | 0.01 | 0.74 | 0.54 | 0.00 | 0.42 | 0.55 | 0.33 | 0.81 |
| microglial cell | 369 | 0.09 | 0.00 | 0.75 | 0.27 | 0.00 | 0.50 | 0.25 | 0.19 | 0.57 |
| muscle cell | 359 | 0.72 | 0.00 | 0.98 | 0.94 | 0.00 | 0.92 | 0.75 | 0.94 | 0.96 |
| enterocyte of epithelium proper of jejunum | 353 | 0.00 | 0.00 | 0.65 | 0.56 | 0.00 | 0.93 | 0.56 | 0.40 | 0.93 |
| mesothelial cell | 316 | 0.61 | 0.47 | 0.94 | 0.83 | 0.00 | 0.61 | 0.50 | 0.74 | 0.78 |
| colon endothelial cell | 305 | 0.02 | 0.00 | 0.87 | 0.35 | 0.00 | 0.57 | 0.26 | 0.33 | 0.82 |
| colon macrophage | 293 | 0.20 | 0.00 | 0.83 | 0.46 | 0.00 | 0.80 | 0.30 | 0.27 | 0.88 |
| serous cell of epithelium of trachea | 299 | 0.40 | 0.00 | 0.87 | 0.65 | 0.00 | 0.34 | 0.49 | 0.55 | 0.84 |
| ciliated epithelial cell | 286 | 0.87 | 0.00 | 0.98 | 0.83 | 0.00 | 0.96 | 0.98 | 0.95 | 0.98 |
| Schwann cell | 290 | 0.71 | 0.32 | 0.87 | 0.72 | 0.00 | 0.56 | 0.79 | 0.75 | 0.85 |
| supporting cell of vestibular epithelium | 239 | 0.84 | 0.00 | 0.72 | 0.78 | 0.00 | 0.80 | 1.00 | 0.88 | 0.99 |
| mucus secreting cell | 246 | 0.52 | 0.02 | 0.89 | 0.74 | 0.00 | 0.72 | 0.70 | 0.74 | 0.88 |
| enteroendocrine cell of small intestine | 239 | 0.67 | 0.08 | 0.88 | 0.77 | 0.00 | 0.85 | 0.96 | 0.85 | 0.94 |
| ovarian surface epithelial cell | 222 | 0.43 | 0.07 | 0.93 | 0.87 | 0.00 | 0.62 | 0.84 | 0.70 | 0.96 |
| transit amplifying cell of colon | 214 | 0.50 | 0.17 | 0.66 | 0.48 | 0.00 | 0.35 | 0.75 | 0.67 | 0.86 |
| glandular epithelial cell | 209 | 0.58 | 0.03 | 0.91 | 0.67 | 0.00 | 0.88 | 0.96 | 0.72 | 0.99 |
| melanocyte | 210 | 0.65 | 0.30 | 0.86 | 0.66 | 0.00 | 0.75 | 0.85 | 0.75 | 0.92 |
| tracheal goblet cell | 212 | 0.00 | 0.14 | 0.87 | 0.70 | 0.00 | 0.70 | 0.83 | 0.69 | 0.94 |
| hepatic stellate cell | 197 | 0.36 | 0.00 | 0.83 | 0.40 | 0.00 | 0.51 | 0.54 | 0.36 | 0.73 |
| bronchial smooth muscle cell | 194 | 0.00 | 0.00 | 0.75 | 0.49 | 0.00 | 0.31 | 0.48 | 0.53 | 0.77 |
| paneth cell of colon | 196 | 0.44 | 0.07 | 0.76 | 0.62 | 0.00 | 0.47 | 0.81 | 0.37 | 0.90 |
| tongue muscle cell | 184 | 0.43 | 0.00 | 0.90 | 0.74 | 0.00 | 0.55 | 0.72 | 0.51 | 0.95 |
| leukocyte | 173 | 0.10 | 0.01 | 0.63 | 0.13 | 0.00 | 0.33 | 0.29 | 0.15 | 0.47 |
| tuft cell of colon | 146 | 0.00 | 0.03 | 0.88 | 0.60 | 0.00 | 0.83 | 0.90 | 0.90 | 0.98 |
| slow muscle cell | 155 | 0.70 | 0.15 | 0.87 | 0.77 | 0.00 | 0.58 | 0.91 | 0.91 | 0.95 |
| ionocyte | 147 | 0.58 | 0.05 | 0.82 | 0.64 | 0.00 | 0.34 | 0.86 | 0.80 | 0.93 |
| connective tissue cell | 132 | 0.01 | 0.00 | 0.97 | 0.82 | 0.00 | 0.37 | 0.47 | 0.25 | 0.94 |
| neuro-medullary thymic epithelial cell | 123 | 0.28 | 0.20 | 0.85 | 0.74 | 0.00 | 0.54 | 0.42 | 0.49 | 0.48 |
| sebum secreting cell | 117 | 0.00 | 0.02 | 0.93 | 0.48 | 0.00 | 0.65 | 0.94 | 0.64 | 0.93 |
| endothelial cell of arteriole | 121 | 0.00 | 0.00 | 0.94 | 0.32 | 0.00 | 0.72 | 0.52 | 0.49 | 0.98 |
| male germ cell | 104 | 0.00 | 0.00 | 0.90 | 0.83 | 0.00 | 0.79 | 1.00 | 0.78 | 0.99 |
| type B pancreatic cell | 92 | 0.81 | 0.00 | 0.94 | 0.86 | 0.00 | 0.92 | 1.00 | 0.96 | 0.99 |
| hematopoietic cell | 90 | 0.00 | 0.00 | 0.75 | 0.61 | 0.00 | 0.34 | 0.59 | 0.43 | 0.83 |
| plasmacytoid dendritic cell | 94 | 0.53 | 0.29 | 0.78 | 0.67 | 0.00 | 0.15 | 0.62 | 0.39 | 0.71 |
| neuron | 78 | 0.00 | 0.00 | 0.99 | 0.81 | 0.00 | 0.61 | 0.65 | 0.79 | 0.96 |
| myeloid cell | 76 | 0.00 | 0.00 | 0.66 | 0.03 | 0.00 | 0.29 | 0.34 | 0.28 | 0.74 |
| myo-medullary thymic epithelial cell | 74 | 0.68 | 0.00 | 0.95 | 0.85 | 0.00 | 0.91 | 0.90 | 0.94 | 0.96 |
| Langerhans cell | 66 | 0.00 | 0.00 | 0.85 | 0.54 | 0.00 | 0.24 | 0.39 | 0.42 | 0.87 |
| interstitial cell of Cajal | 64 | 0.00 | 0.00 | 0.95 | 0.72 | 0.00 | 0.61 | 0.58 | 0.60 | 0.94 |
| retinal pigment epithelial cell | 61 | 0.83 | 0.00 | 0.98 | 0.91 | 0.00 | 0.95 | 1.00 | 0.93 | 0.99 |
| peritubular myoid cell | 59 | 0.20 | 0.00 | 0.72 | 0.63 | 0.00 | 0.55 | 0.53 | 0.62 | 0.83 |
| spermatogonium | 54 | 0.00 | 0.00 | 0.74 | 0.57 | 0.00 | 0.56 | 0.94 | 0.80 | 0.89 |
| retinal bipolar neuron | 50 | 0.00 | 0.04 | 0.86 | 0.72 | 0.00 | 0.30 | 0.72 | 0.89 | 0.90 |
| endothelial cell of venule | 45 | 0.00 | 0.00 | 0.96 | 0.27 | 0.00 | 0.57 | 0.85 | 0.54 | 0.97 |
| vestibular dark cell | 44 | 0.00 | 0.00 | 0.45 | 0.23 | 0.00 | 0.34 | 1.00 | 0.93 | 0.96 |
| pancreatic A cell | 46 | 0.67 | 0.00 | 0.92 | 0.87 | 0.00 | 0.95 | 1.00 | 1.00 | 1.00 |
| type L enteroendocrine cell | 40 | 0.00 | 0.09 | 0.89 | 0.73 | 0.00 | 0.84 | 0.95 | 0.93 | 1.00 |
| medullary thymic epithelial cell | 40 | 0.00 | 0.00 | 0.75 | 0.26 | 0.00 | 0.40 | 0.94 | 0.73 | 0.92 |
| adipocyte | 37 | 0.00 | 0.00 | 0.69 | 0.48 | 0.00 | 0.55 | 0.69 | 0.46 | 0.88 |
| transit amplifying cell of small intestine | 34 | 0.00 | 0.00 | 0.40 | 0.33 | 0.00 | 0.14 | 0.83 | 0.75 | 0.91 |
| taste receptor cell | 29 | 0.00 | 0.00 | 0.82 | 0.47 | 0.00 | 0.09 | 0.84 | 0.27 | 0.89 |
| enterochromaffin-like cell | 25 | 0.00 | 0.01 | 0.83 | 0.59 | 0.00 | 0.85 | 1.00 | 0.89 | 0.96 |
| enteroendocrine cell | 21 | 0.00 | 0.00 | 0.91 | 0.73 | 0.00 | 0.72 | 0.93 | 0.84 | 0.93 |
| pulmonary ionocyte | 23 | 0.00 | 0.00 | 0.75 | 0.45 | 0.00 | 0.25 | 0.96 | 0.73 | 0.92 |
| glial cell | 19 | 0.00 | 0.00 | 0.75 | 0.62 | 0.00 | 0.25 | 0.76 | 0.30 | 0.64 |
| oocyte | 13 | 0.00 | 0.03 | 0.90 | 0.77 | 0.00 | 0.37 | 0.90 | 0.87 | 0.87 |
| serous cell of epithelium of bronchus | 15 | 0.00 | 0.00 | 0.93 | 0.12 | 0.00 | 0.14 | 0.71 | 0.94 | 1.00 |
| radial glial cell | 13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.25 | 0.17 | 0.40 |
| Leydig cell | 7 | 0.00 | 0.00 | 0.17 | 0.22 | 0.00 | 0.20 | 0.16 | 0.45 | 0.88 |
| pancreatic D cell | 8 | 0.00 | 0.00 | 0.50 | 0.57 | 0.00 | 0.89 | 1.00 | 1.00 | 1.00 |
| T follicular helper cell | 5 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.62 | 0.42 | 0.89 |
| retina horizontal cell | 4 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.29 | 1.00 | 0.89 | 0.86 |
| erythroid lineage cell | 2 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.80 | 0.80 | 0.67 |
| pancreatic PP cell | 2 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 1.00 | 1.00 | 1.00 |
| epithelial fate stem cell | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.12 | 0.06 | 0.50 | 1.00 |
| mesenchymal cell | 1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.15 | 1.00 | 1.00 |

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# References

Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues, The Tabula Sapiens Consortium; bioRxiv, doi: https://doi.org/10.1101/2024.12.03.626516