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Browse files- README.md +4 -6
- l2g_model_1006.pkl +1 -1
README.md
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# Model description
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The locus-to-gene (L2G) model derives features to prioritise likely causal genes at each GWAS locus based on genetic and functional genomics features. The main categories of predictive features are:
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- Distance: (from credible set variants to gene)
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- Molecular QTL Colocalization
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- Chromatin Interaction: (e.g., promoter-capture Hi-C)
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## Training Procedure
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### Hyperparameters
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To use the model, you can load it using the `LocusToGeneModel.load_from_hub` method. This will return a `LocusToGeneModel` object that can be used to make predictions on a feature matrix.
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The model can then be used to make predictions using the `predict` method.
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# Citation
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https://doi.org/10.1038/s41588-021-00945-5
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# Training Procedure
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Gradient Boosting Classifier
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# License
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MIT
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# Model description
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The locus-to-gene (L2G) model derives features to prioritise likely causal genes at each GWAS locus based on genetic and functional genomics features. The main categories of predictive features are:
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- Distance: (from credible set variants to gene)
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- Molecular QTL Colocalization
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- Chromatin Interaction: (e.g., promoter-capture Hi-C)
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## Training Procedure
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Gradient Boosting Classifier
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### Hyperparameters
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To use the model, you can load it using the `LocusToGeneModel.load_from_hub` method. This will return a `LocusToGeneModel` object that can be used to make predictions on a feature matrix.
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The model can then be used to make predictions using the `predict` method.
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More information can be found at: https://opentargets.github.io/gentropy/python_api/methods/l2g/model/
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# Citation
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https://doi.org/10.1038/s41588-021-00945-5
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# License
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MIT
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l2g_model_1006.pkl
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