text: 近年的研究逐渐认识到部分CVID的发病机制与T细胞调节网络失常有关，部分患儿CD8+</sup>T细胞增多T细胞减少CD4/CD8T细胞比值下降T细胞分泌的干扰素γ可抑制B细胞合成和分泌Ig，CVID的遗传方式不定，可为常染色体隐性或显性，也可为X连锁，但更常见为无遗传家系的散发病例。
entities.entity: CVID
entities.label: dis
entities.entity: T细胞
entities.label: bod
entities.entity: T细胞
entities.label: bod
entities.entity: T细胞增多
entities.label: sym
entities.entity: T细胞
entities.label: bod
entities.entity: T细胞减少
entities.label: sym
entities.entity: CD4/CD8T细胞
entities.label: bod
entities.entity: CD4/CD8T细胞比值下降
entities.label: sym
entities.entity: T细胞
entities.label: bod
entities.entity: 干扰素γ
entities.label: bod
entities.entity: B细胞
entities.label: bod
entities.entity: Ig
entities.label: bod
entities.entity: CVID
entities.label: dis
entities.entity: 常染色体
entities.label: bod
entities.entity: X连锁
entities.label: bod