text: 4.WHOⅣ型（ISKDC5a，5b）弥漫增生性肾炎，狼疮肾炎中半数以上是本型，病变广泛且严重，几乎全部肾小球受累，呈活动性毛细血管内增殖性改变，中性粒细胞渗出，纤维素样坏死；毛细血管壁显著增厚，管壁内透明血栓；坏死节段常见细胞性新月体；严重病例呈弥漫性坏死和新月体性肾炎，部分病例呈不同程度肾小球硬化。
entities.entity: WHOⅣ型
entities.label: dis
entities.entity: ISKDC5a，5b
entities.label: dis
entities.entity: 弥漫增生性肾炎
entities.label: dis
entities.entity: 狼疮肾炎
entities.label: dis
entities.entity: 肾小球
entities.label: bod
entities.entity: 几乎全部肾小球受累
entities.label: sym
entities.entity: 活动性毛细血管
entities.label: bod
entities.entity: 活动性毛细血管内增殖性改变
entities.label: sym
entities.entity: 中性粒细胞
entities.label: bod
entities.entity: 中性粒细胞渗出
entities.label: sym
entities.entity: 纤维素样坏死
entities.label: sym
entities.entity: 毛细血管壁
entities.label: bod
entities.entity: 毛细血管壁显著增厚
entities.label: sym
entities.entity: 管壁内透明血栓
entities.label: sym
entities.entity: 坏死节段常见细胞性新月体
entities.label: sym
entities.entity: 弥漫性坏死
entities.label: sym
entities.entity: 新月体性肾炎
entities.label: dis
entities.entity: 肾小球硬化
entities.label: dis