text: 在使用茶碱类药物时要注意几个方面：①由于茶碱主要在肝脏代谢，因而严重的不良反应更容易出现在充血性心力衰竭、肝硬化和呼吸衰竭的患儿；②许多药物会干扰茶碱的代谢，引起茶碱血药浓度升高或降低，（表8-8）；③个体差异大，治疗要强调个体化和测定血浓度；④不要超过每日总的茶碱剂量，（表8-8）。
entities.entity: 茶碱类药物
entities.label: dru
entities.entity: 茶碱
entities.label: dru
entities.entity: 肝脏
entities.label: bod
entities.entity: 充血性心力衰竭
entities.label: dis
entities.entity: 肝硬化
entities.label: dis
entities.entity: 呼吸衰竭
entities.label: dis
entities.entity: 茶碱
entities.label: dru
entities.entity: 茶碱血药浓度
entities.label: ite
entities.entity: 血浓度
entities.label: ite
entities.entity: 茶碱
entities.label: dru