text: 现已发现：①淋巴细胞可产生一种29kd的多肽，其可导致肾小球滤过膜多阴离子减少，而出现蛋白尿；②刀豆素（ConA）刺激下的淋巴细胞可产生60～160kd的肾小球通透因子（glomerularpermeabilityfactor，GPF），GPF可直接引起蛋白尿；③淋巴细胞还可通过分泌12～18kd的可溶免疫反应因子（solubleimmuneresponsesuppressor，SIRS）而导致蛋白尿。
entities.entity: 淋巴细胞
entities.label: bod
entities.entity: 29kd
entities.label: bod
entities.entity: 多肽
entities.label: bod
entities.entity: 肾小球滤过膜
entities.label: bod
entities.entity: 出现蛋白尿
entities.label: sym
entities.entity: 刀豆素
entities.label: bod
entities.entity: ConA
entities.label: bod
entities.entity: 淋巴细胞
entities.label: bod
entities.entity: 肾小球通透因子
entities.label: bod
entities.entity: glomerularpermeabilityfactor
entities.label: bod
entities.entity: GPF
entities.label: bod
entities.entity: GPF
entities.label: bod
entities.entity: 蛋白尿
entities.label: sym
entities.entity: 淋巴细胞
entities.label: bod
entities.entity: 可溶免疫反应因子
entities.label: bod
entities.entity: solubleimmuneresponsesuppressor
entities.label: bod
entities.entity: SIRS
entities.label: bod
entities.entity: 蛋白尿
entities.label: sym