text: 肾素血管紧张素醛固酮系统和交感神经系统的活化直接导致心肌毒性和外周血管收缩心室重构和心室功能恶化心脏扩大心房利钠因子释放尿钠增多、血管扩张的作用，但该因子导致心力衰竭的机制不明。
entities.entity: 肾素血管紧张素醛固酮系统
entities.label: bod
entities.entity: 交感神经系统
entities.label: bod
entities.entity: 心肌
entities.label: bod
entities.entity: 血管
entities.label: bod
entities.entity: 心肌毒性和外周血管收缩
entities.label: sym
entities.entity: 心室
entities.label: bod
entities.entity: 心室
entities.label: bod
entities.entity: 心室重构和心室功能恶化
entities.label: sym
entities.entity: 心脏
entities.label: bod
entities.entity: 心脏扩大
entities.label: sym
entities.entity: 心房
entities.label: bod
entities.entity: 心房利钠因子释放
entities.label: sym
entities.entity: 尿钠
entities.label: bod
entities.entity: 血管
entities.label: bod
entities.entity: 心力衰竭
entities.label: dis