text: 长期服用皮质激素，可产生许多不良反应，如脂肪代谢紊乱，表现为水肿、体脂分布异常及库欣貌；蛋白质分解代谢增加出现氮负平衡、肌肉萎缩无力及伤口愈合不良；糖代谢紊乱可引起高血糖和糖尿；水电解质紊乱，出现水钠潴留和高血压；钙磷代谢紊乱发生高尿钙以及骨质稀疏；胃肠道可发生消化性溃疡，甚至穿孔；神经精神方面有欣快感、兴奋及失眠，严重时发生精神病和癫痫发作；由于抑制抗体形成易发生感染或隐性感染灶（如结核病）的活动和播散；长期用药还可发生白内障及股骨头无菌坏死。
entities.entity: 皮质激素
entities.label: dru
entities.entity: 脂肪代谢紊乱
entities.label: sym
entities.entity: 水肿
entities.label: sym
entities.entity: 体脂分布异常及库欣貌
entities.label: sym
entities.entity: 蛋白质分解代谢增加出现氮负平衡
entities.label: sym
entities.entity: 肌肉萎缩无力及伤口愈合不良
entities.label: sym
entities.entity: 糖代谢紊乱
entities.label: sym
entities.entity: 高血糖
entities.label: sym
entities.entity: 糖尿
entities.label: sym
entities.entity: 水电解质紊乱
entities.label: sym
entities.entity: 水钠潴留
entities.label: sym
entities.entity: 高血压
entities.label: sym
entities.entity: 钙磷代谢紊乱发生高尿钙以及骨质稀疏
entities.label: sym
entities.entity: 胃肠道可发生消化性溃疡，甚至穿孔
entities.label: sym
entities.entity: 神经精神方面有欣快感、兴奋及失眠
entities.label: sym
entities.entity: 精神病
entities.label: sym
entities.entity: 癫痫
entities.label: sym
entities.entity: 感染
entities.label: sym
entities.entity: 隐性感染灶
entities.label: sym
entities.entity: 结核病
entities.label: dis
entities.entity: 白内障
entities.label: dis
entities.entity: 股骨头无菌坏死
entities.label: dis