text: 下丘脑-垂体-性腺轴主要受两种机制调控：一种为性激素依赖性负反馈调控机制，即一定浓度的性激素能抑制GnRH和Gn的分泌，主要在2～3岁以内发挥作用；一种为中枢神经系统内在的抑制机制，如肾上腺能药物可刺激GnRH释放，内源性脑啡肽可抑制GnRH释放的频率，阿片受体拮抗剂纳曲酮可完全抑制Gn的分泌，主要在3～10岁左右发挥作用。
entities.entity: 下丘脑-垂体-性腺轴
entities.label: bod
entities.entity: 性激素
entities.label: bod
entities.entity: 性激素
entities.label: bod
entities.entity: GnRH
entities.label: bod
entities.entity: Gn
entities.label: bod
entities.entity: 中枢神经系统
entities.label: bod
entities.entity: 肾上腺
entities.label: bod
entities.entity: GnRH
entities.label: bod
entities.entity: 内源性脑啡肽
entities.label: dru
entities.entity: GnRH
entities.label: bod
entities.entity: 阿片受体拮抗剂纳曲酮
entities.label: dru
entities.entity: Gn
entities.label: bod