text: 例如在苯丙酮尿症时，苯丙氨酸羟化酶缺乏代谢旁路开放，代谢产物苯乙酸及苯乳酸增高这些物质的毒性作用造成了神经系统的损害造成产物皮质醇及醛固酮缺乏水、电解质紊乱和休克，同时导致睾酮升高底物堆积，或产物缺乏，或旁路代谢产物产生为主，产生病理损害。
entities.entity: 苯丙酮尿症
entities.label: dis
entities.entity: 苯丙氨酸羟化酶
entities.label: bod
entities.entity: 苯丙氨酸羟化酶缺乏
entities.label: sym
entities.entity: 代谢旁路开放
entities.label: sym
entities.entity: 苯乙酸
entities.label: bod
entities.entity: 苯乳酸
entities.label: bod
entities.entity: 代谢产物苯乙酸及苯乳酸增高
entities.label: sym
entities.entity: 神经系统
entities.label: bod
entities.entity: 这些物质的毒性作用造成了神经系统的损害
entities.label: sym
entities.entity: 产物皮质醇
entities.label: bod
entities.entity: 醛固酮
entities.label: bod
entities.entity: 造成产物皮质醇及醛固酮缺乏
entities.label: sym
entities.entity: 水、电解质紊乱
entities.label: sym
entities.entity: 休克
entities.label: sym
entities.entity: 睾酮
entities.label: bod
entities.entity: 同时导致睾酮升高
entities.label: sym
entities.entity: 底物堆积
entities.label: sym
entities.entity: 产物缺乏
entities.label: sym
entities.entity: 旁路代谢产物产生
entities.label: sym