text: 2.FMR-1基因的全突变（fullmutation）FMR-1基因由前突变状态（CGG）53～230扩增至＞230次脆性X综合征，53%的女性携带者表现出轻重程度不等的智力低下，此时称为全突变。
entities.entity: FMR-1基因
entities.label: bod
entities.entity: FMR-1基因的全突变
entities.label: sym
entities.entity: FMR-1基因
entities.label: bod
entities.entity: CGG
entities.label: bod
entities.entity: FMR-1基因由前突变状态（CGG）53～230扩增至＞230次
entities.label: sym
entities.entity: 脆性X综合征
entities.label: dis
entities.entity: 轻重程度不等的智力低下
entities.label: sym
entities.entity: 全突变
entities.label: sym