text: 【诊断和鉴别诊断】根据婴儿期开始呈慢性进行性贫血、脾大和特殊面容，外周血红细胞形态改变，红细胞渗透脆性减低和（或）阳性家庭史，应高度怀疑本病，进一步作血红蛋白电泳、基因分析等检查，可以确诊，但须与缺铁性贫血、遗传性球形细胞增多症、病毒性肝炎或肝硬化等病鉴别。
entities.entity: 慢性进行性贫血
entities.label: dis
entities.entity: 脾大
entities.label: sym
entities.entity: 特殊面容
entities.label: sym
entities.entity: 外周血红细胞形态改变
entities.label: sym
entities.entity: 红细胞渗透脆性减低
entities.label: sym
entities.entity: 血红蛋白电泳
entities.label: pro
entities.entity: 基因分析
entities.label: pro
entities.entity: 缺铁性贫血
entities.label: dis
entities.entity: 遗传性球形细胞增多症
entities.label: dis
entities.entity: 病毒性肝炎
entities.label: dis
entities.entity: 肝硬化
entities.label: dis