text: 1.原发性（1）遗传：正常生长激素功能的维持，需要下丘脑GHRH的分泌到GH、IGF-1的分泌，受体效应都要完整，目前下丘脑-垂体-IGF-1轴的多种基因都已发现突变，导致功能障碍，包括与垂体发育有关的基因缺陷、GH、IGF-1的编码基因和受体基因，例如PROP-1、POU1F1、GHRH、GHRH受体、GH、GH受体、IGF-1以及IGF-1受体等。
entities.entity: 生长激素
entities.label: bod
entities.entity: 下丘脑GHRH
entities.label: bod
entities.entity: GH
entities.label: bod
entities.entity: IGF-1
entities.label: bod
entities.entity: 受体
entities.label: bod
entities.entity: 下丘脑-垂体-IGF-1轴
entities.label: bod
entities.entity: 突变
entities.label: sym
entities.entity: 垂体
entities.label: bod
entities.entity: 基因缺陷
entities.label: sym
entities.entity: GH
entities.label: bod
entities.entity: IGF-1
entities.label: bod
entities.entity: PROP-1
entities.label: bod
entities.entity: POU1F1
entities.label: bod
entities.entity: GHRH受体
entities.label: bod
entities.entity: GH
entities.label: bod
entities.entity: GH受体
entities.label: bod
entities.entity: IGF-1
entities.label: bod
entities.entity: IGF-1受体
entities.label: bod