text: 约85%AS病人为性连锁显性遗传（XLinkedAS，XLAS），致病基因定位于X染色体长臂中段Xq22，为编码Ⅳ型胶原α5链（COL4A5）基因突变所致；其余病人为常染色体隐性遗传（autosomalrecessiveAS，ARAS）和常染色体显性遗传AS（autosomaldominantAS，ADAS），前者致病基因为COL4A3或COL4A4基因，而后者具有遗传多源性。
entities.entity: AS
entities.label: dis
entities.entity: 性连锁显性遗传
entities.label: sym
entities.entity: XLinkedAS
entities.label: sym
entities.entity: XLAS
entities.label: sym
entities.entity: X染色体长臂中段Xq22
entities.label: bod
entities.entity: Ⅳ型胶原α5链
entities.label: bod
entities.entity: COL4A5
entities.label: bod
entities.entity: 编码Ⅳ型胶原α5链（COL4A5）基因突变
entities.label: sym
entities.entity: 常染色体隐性遗传
entities.label: sym
entities.entity: autosomalrecessiveAS
entities.label: dis
entities.entity: ARAS
entities.label: dis
entities.entity: 常染色体显性遗传AS
entities.label: dis
entities.entity: autosomaldominantAS
entities.label: dis
entities.entity: ADAS
entities.label: dis
entities.entity: COL4A3或COL4A4基因
entities.label: bod