text: 1.促性腺激素释放激素类似物（GnRHa）此类药物是将GnRH分子结构中第6位甘氨酸换成D-色氨酸（达菲林和达必佳）及D-亮氨酸（抑那通）等的长效合成激素，其作用原理是利用下丘脑激素类似物竞争性抑制自身分泌的GnRH，减少垂体促性腺激素分泌。
entities.entity: 促性腺激素释放激素类似物
entities.label: dru
entities.entity: GnRHa
entities.label: dru
entities.entity: GnRH
entities.label: bod
entities.entity: 甘氨酸
entities.label: dru
entities.entity: D-色氨酸
entities.label: dru
entities.entity: 达菲林
entities.label: dru
entities.entity: 达必佳
entities.label: dru
entities.entity: D-亮氨酸
entities.label: dru
entities.entity: 抑那通
entities.label: dru
entities.entity: 下丘脑激素类似物
entities.label: dru
entities.entity: GnRH
entities.label: bod
entities.entity: 垂体促性腺激素
entities.label: bod