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README.md ADDED
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+ ---
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+ language: rna
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+ tags:
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+ - Biology
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+ - RNA
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+ license:
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+ - agpl-3.0
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+ size_categories:
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+ - 1K<n<10K
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+ task_categories:
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+ - text-generation
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+ - fill-mask
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+ task_ids:
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+ - language-modeling
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+ - masked-language-modeling
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+ pretty_name: EternaBench-Switch
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+ library_name: multimolecule
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+ ---
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+
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+ # EternaBench-Switch
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+
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+ ![EternaBench-Switch](https://eternagame.org/sites/default/files/thumb_eternabench_paper.png)
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+
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+ EternaBench is a database comprising the diverse high-throughput structural data gathered through the crowdsourced RNA design project Eterna, to evaluate the performance of a wide set of structure algorithms.
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+
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+ ## Disclaimer
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+
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+ This is an UNOFFICIAL release of the [EternaBench-Switch](https://github.com/eternagame/EternaBench) by Hannah K. Wayment-Steele, et al.
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+
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+ **The team releasing EternaBench-Switch did not write this dataset card for this dataset so this dataset card has been written by the MultiMolecule team.**
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+
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+ ## Dataset Description
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+
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+ - **Homepage**: https://multimolecule.danling.org/datasets/eternabench_switch
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+ - **datasets**: https://huggingface.co/datasets/multimolecule/eternabench-switch
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+ - **Point of Contact**: [Rhiju Das](https://biochemistry.stanford.edu/people/rhiju-das/)
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+
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+ ## Example Entry
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+
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+ | ID | design_name | sequence | structure | reactivity | errors | signal_to_noise |
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+ | -------- | ---------------------- | ---------------- | ---------------- | -------------------------- | --------------------------- | --------------- |
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+ | 769337-1 | d+m plots weaker again | GGAAAAAAAAAAA... | ................ | [0.642,1.4853,0.1629, ...] | [0.3181,0.4221,0.1823, ...] | 3.227 |
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+
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+ ## Column Description
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+
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+ The EternaBench-Switch dataset consists of the following columns, providing crucial insights for understanding RNA stability for vaccine design:
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+
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+ - **ID**:
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+ A unique identifier for each RNA sequence entry.
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+
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+ - **design_name**:
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+ The name given to each RNA design by contributors, used for easy reference.
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+
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+ - **sequence**:
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+ The nucleotide sequence of the RNA, using standard bases.
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+
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+ - **structure**:
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+ The predicted secondary structure of the RNA, represented using dot-bracket notation.
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+ The structure helps determine the likely secondary interactions within each RNA molecule.
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+
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+ - **reactivity**:
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+ A list of floating-point values that provide an estimate of the likelihood of the RNA backbone being cut at each nucleotide position.
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+ These values help determine the stability of the RNA structure under various experimental conditions.
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+
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+ - **errors**:
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+ Arrays of floating-point numbers indicating the experimental errors corresponding to the measurements in the **reactivity**.
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+ These values help quantify the uncertainty in the degradation rates and reactivity measurements.
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+
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+ ## Related Datasets
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+
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+ - [EternaBench-CM](https://huggingface.co/datasets/multimolecule/eternabench-cm)
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+ - [EternaBench-Switch](https://huggingface.co/datasets/multimolecule/eternabench-switch)
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+
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+ ## License
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+
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+ This dataset is licensed under the [AGPL-3.0 License](https://www.gnu.org/licenses/agpl-3.0.html).
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+
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+ ```spdx
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+ SPDX-License-Identifier: AGPL-3.0-or-later
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+ ```
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+
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+ ## Citation
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+
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+ ```bibtex
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+ @article{waymentsteele2022rna,
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+ author = {Wayment-Steele, Hannah K and Kladwang, Wipapat and Strom, Alexandra I and Lee, Jeehyung and Treuille, Adrien and Becka, Alex and {Eterna Participants} and Das, Rhiju},
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+ journal = {Nature Methods},
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+ month = oct,
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+ number = 10,
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+ pages = {1234--1242},
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+ publisher = {Springer Science and Business Media LLC},
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+ title = {{RNA} secondary structure packages evaluated and improved by high-throughput experiments},
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+ volume = 19,
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+ year = 2022
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+ }
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+ ```
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