document: ECG-gated / sup 18/F-FDG positron emission tomography . Single test evaluation of segmental metabolism , function and contractile reserve in patients with coronary artery disease and regional dysfunction / sup 18/F-fluorodeoxyglucose -LRB- / sup 18/F-FDG -RRB- - positron emission tomography -LRB- PET -RRB- provides information about myocardial glucose metabolism to diagnose myocardial viability . Additional information about the functional status is necessary . Comparison of tomographic metabolic PET with data from other imaging techniques is always hampered by some transfer uncertainty and scatter . We wanted to evaluate a new Fourier-based ECG-gated PET technique using a high resolution scanner providing both metabolic and functional data with respect to feasibility in patients with diseased left ventricles . Forty-five patients with coronary artery disease and at least one left ventricular segment with severe hypokinesis or akinesis at biplane cineventriculography were included . A new Fourier-based ECG-gated metabolic / sup 18/F-FDG-PET was performed in these patients . Function at rest and / sup 18/F-FDG uptake were examined in the PET study using a 36-segment model . Segmental comparison with ventriculography revealed a high reliability in identifying dysfunctional segments -LRB- > 96 % -RRB- . / sup 18/F-FDG uptake of normokinetic/hypokinetic/akinetic segments was 75.4 + or-7 .5 , 65.3 + or-10 .5 , and 35.9 + or-15 .2 % -LRB- p < 0.001 -RRB- . In segments > or = 70 % / sup 18/F-FDG uptake no akinesia was observed . No residual function was found below 40 % / sup 18/F-FDG uptake . An additional dobutamine test was performed and revealed inotropic reserve -LRB- viability -RRB- in 42 akinetic segments and 45 hypokinetic segments . ECG-gated metabolic PET with pixel-based Fourier smoothing provides reliable data on regional function . Assessment of metabolism and function makes complete judgement of segmental status feasible within a single study without any transfer artefacts or test-to-test variability . The results indicate the presence of considerable amounts of viable myocardium in regions with an uptake of 40-50 % / sup 18/F-FDG
doc_bio_tags: O O O O O O O O O O O O O O O O O O O O B O B I I O B I O O O O O O O O O O O O O O O O O O B I I O O B I O O O O O B O O O O O O O O O O O O O O O O O O O O B I O O O O O O O O O O O O O O O B I I O O O O B O O O O O O B O B I I O O B O B I I O O O O B I I O B I O B O B I O O O O O O O O O O O O O O O B O O O O O O O O O O O O O O O O O O O O O O O B O O O O O O B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B I O O O O O O O O O O O O B I O O O O B I O O O O O B I O O B I O O O O O O O O O O O O B I O O O O O O O O O O B I O O O O O O O B I O O O O O O O O O O O O O B I O O O O O O O O O O O
extractive_keyphrases: ventriculography dysfunctional segments residual function dobutamine test inotropic reserve akinetic segments hypokinetic segments regional function segmental status transfer artefacts viable myocardium regional dysfunction myocardial glucose metabolism myocardial viability functional transfer uncertainty high resolution scanner patients diseased left ventricles coronary artery disease left ventricular segment severe hypokinesis akinesis biplane cineventriculography
abstractive_keyphrases: fourier-based ecg-gated metabolic /sup 18/f-fluorodeoxyglucose-positron emission tomography /sup 18/f-fluorodeoxyglucose uptake thirty six-segment model normokinetic/hypokinetic/akinetic segments pixel-based fourier smoothing fourier-based ecg-gated pet technique