text: Renin Angiotensin System RAS and Immune System Profile in Specific Subgroups with COVID 19 The identification of vulnerable subgroups and risk factors associated with the susceptibility to severe acute respiratory syndrome coronavirus 2 SARS CoV 2 infection and coronavirus disease 2019 COVID 19 is of utmost importance in a pandemic scenario Potential interactions between renin angiotensin system RAS immune markers and COVID 19 play a role in disease outcome in specific groups of patients This review aimed to describe the particularities of the RAS and the immune system profile of particular subgroups of patients This non systematic review summarizes evidence on SARS CoV 2 infection in specific subgroups of patients and possible relationships between immune system RAS and the pathophysiology of COVID 19 The RAS and the immune system exert a role in the pathogenesis and prognosis of COVID 19 mainly in cases of hypertension diabetes obesity and other chronic diseases The overactivation of the ACE Ang II AT1R axis and the enhancement of inflammation contribute to deleterious effects of COVID 19 Likewise pregnant women and elderly patients usually display immune responses that are less effective in withstanding exposition to viruses while children are relatively protected against severe complications of COVID 19 Women conversely exhibit stronger antiviral responses and are less sensitive to the effects of increased Ang II Future Perspectives The recognition of vulnerable subgroups and risk factors for disease severity is essential to better understand the pandemic Precision medicine tools including proteomics and metabolomics approaches identified metabolic patterns of the severe form of disease and might be the alternative to diagnose evaluate and predict the prognosis and the efficiency of therapies 