text: Erythema Multiforme and COVID 19 What Do We Know i Background i Erythema multiforme EM is an acute cutaneous eruption often associated with infections and more rarely with drugs This review aimed to evaluate the association between erythema multiforme and coronavirus disease 2019 COVID 19 i Methods i A systematic search of PubMed MEDLINE Scimago Scopus and ISI Web of Science was performed Original articles case series or case reports were evaluated and selected i Results i Fourteen articles were selected describing a total of 70 patients EM is a cutaneous eruption rarely occurring in COVID 19 and is in most cases associated with a hypersensitivity reaction to the virus In these cases EM seems to affect patients younger than 30 years or older than 55 years Infrequently some drugs used in the management of COVID 19 may induce EM especially hydroxychloroquine The three groups of patients seem to have different clinical characteristics and courses i Conclusions i From these data it is possible to preliminarily propose that EM or EM like eruptions linked to COVID 19 might be divided into three types the virus related juvenile type affecting patients 30 year old the virus related older type affecting patients 55 years and the drug induced type The occurrence of a skin rash does not seem to be related to the severity and clinical course of COVID 19 