text: Immunomodulation and immunotherapeutics of COVID 19 Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 2019 a pandemic which was originated from Wuhan city of China The pandemic has affected millions of people worldwide The pathogenesis of SARS CoV 2 is characterized by a cytokine storm in the blood cytokinemia and tissues especially the lungs One of the major repercussions of this inflammatory process is the endothelial injury causing intestinal bleeding coagulopathy and thromboembolism which result in various sudden and unexpected post COVID complications including kidney failure myocardial infarction or multiorgan failure In this review we have summarized the immune responses biochemical changes and inflammatory responses in the human body after infection with the SARS CoV 2 virus The increased amount of inflammatory cytokines chemokines and involvement of complement proteins in inflammatory reaction increase the risk of occurrence of disease 