text: Post Acute Sequelae of COVID 19 and Cardiovascular Autonomic Dysfunction What Do We Know Post acute sequelae of SARS CoV 2 PASC or long COVID syndrome is emerging as a major health issue in patients with previous SARS CoV 2 infection Symptoms commonly experienced by patients include fatigue palpitations chest pain dyspnea reduced exercise tolerance and brain fog Additionally symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous system Signs of cardiovascular autonomic dysfunction appear to be common in PASC and are similar to those observed in postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia In this review we report on the epidemiology of PASC discuss current evidence and possible mechanisms underpinning the dysregulation of the autonomic nervous system and suggest nonpharmacological and pharmacological interventions to treat and relieve symptoms of PASC associated dysautonomia 