text: Role of senescence in the chronic health consequences of COVID 19 While the full impact of COVID 19 is not yet clear early studies have indicated that upwards of 10 of patients experience COVID 19 symptoms longer than 3 weeks known as Long Haulers Syndrome or PACS postacute sequelae of SARS CoV 2 infection There is little known about risk factors or predictors of susceptibility for Long Haulers Syndrome but older adults are at greater risk for severe outcomes and mortality from COVID 19 The pillars of aging including cellular senescence telomere dysfunction impaired proteostasis mitochondrial dysfunction deregulated nutrient sensing genomic instability progenitor cell exhaustion altered intercellular communication and epigenetic alterations that contribute to age related dysfunction and chronic diseases the Geroscience Hypothesis may interfere with defenses against viral infection and consequences of these infections Heightening of the low grade inflammation that is associated with aging may generate an exaggerated response to an acute COVID 19 infection Innate immune system dysfunction that leads to decreased senescent cell removal and or increased senescent cell formation could contribute to accumulation of senescent cells with both aging and viral infections These processes may contribute to increased risk for long term COVID 19 sequelae in older or chronically ill patients Hence senolytics and other geroscience interventions that may prolong healthspan and alleviate chronic diseases and multimorbidity linked to fundamental aging processes might be an option for delaying preventing or alleviating Long Haulers Syndrome 