text: Acute disseminated encephalomyelitis and COVID 19 A systematic synthesis of worldwide cases Acute disseminated encephalomyelitis ADEM has been reported after coronavirus disease 2019 COVID 19 In this review we systematically included worldwide reported cases on this association We included 30 case reports pediatric and adults and explored epidemiological and clinical evidence We described time to diagnosis clinical imaging and laboratory features response to treatment regimens and differences regarding severity Also an original case report was presented Neurologists must be alert to the occurrence of multifocal neurological symptoms with or without encephalopathy in patients recovered from COVID 19 Timely MRI studies should be performed to establish the diagnosis and to consider early corticosteroid based treatment 