text: Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection A State of the Art Review The vast majority of patients 99 with severe acute respiratory syndrome coronavirus 2 survive immediate infection but remain at risk for persistent and or delayed multisystem This review of published reports through May 31 2021 found that manifestations of postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection PASC affect between 33 and 98 of coronavirus disease 2019 survivors and comprise a wide range of symptoms and complications in the pulmonary cardiovascular neurologic psychiatric gastrointestinal renal endocrine and musculoskeletal systems in both adult and pediatric populations Additional complications are likely to emerge and be identified over time Although data on PASC risk factors and vulnerable populations are scarce evidence points to a disproportionate impact on racial ethnic minorities older patients patients with preexisting conditions and rural residents Concerted efforts by researchers health systems public health agencies payers and governments are urgently needed to better understand and mitigate the long term effects of PASC on individual and population health 