text: COVID 19 and BRD4 a stormy and cardiotoxic bromo romance Severe systemic inflammation in COVID 19 patients can lead to dysfunction of multiple organs including the heart Using an ex vivo cardiac organoid system Mills et al discovered that inhibitors of the chromatin reader protein bromodomain containing protein 4 protect cardiomyocytes from COVID associated cytokine storm We briefly review these important findings and highlight the translational significance of the work 