text: Pulmonary Embolism in Patients with COVID 19 Comparison between Different Care Settings The clinical characteristics and outcomes of patients with coronavirus disease 2019 COVID 19 who develop pulmonary embolism PE in the full spectrum of patient care settings need to be elucidated The aim of this study was to compare the clinical characteristics treatment and 90 day outcomes in patients diagnosed with PE while recovering from COVID 19 in the outpatient setting versus those who were diagnosed with PE while being hospitalized with COVID 19 Data from the international Registro Informatizado de Enfermedad TromboEmbólica RIETE registry were used The major study outcomes were all cause death major bleeding and venous thromboembolism VTE recurrences during the first 90 days after PE From March 2020 to March 2021 737 patients with COVID 19 experienced acute PE Of these 340 46 were recovering from COVID 19 as outpatients 267 patients who had been treated at home for COVID 19 and 73 discharged after being hospitalized with COVID 19 Compared with inpatients with COVID 19 those recovering in the outpatient setting upon PE were less likely to be men odds ratio OR 0 54 95 confidence interval CI 0 40 0 72 and less likely to have hypertension OR 0 55 95 CI 0 41 0 74 or diabetes OR 0 51 95 CI 0 33 0 76 At 90 day follow up eight patients none recovering from COVID 19 as outpatient vs 2 4 of inpatients with COVID 19 developed recurrent VTE 34 1 9 vs 7 9 had major bleeding and 128 10 vs 24 died On multivariable analysis inpatients with COVID 19 were at a higher risk of major bleeding adjusted hazard ratio HR 6 80 95 CI 1 52 30 4 or death adjusted HR 2 24 95 CI 1 40 3 58 In conclusion using a large multinational registry of patients with COVID 19 who experienced PE thromboembolic episodes occurring in those recovering from COVID 19 as outpatients were associated with less ominous outcomes than inpatients with COVID 19 