text: Long term clinical and serological follow up of paediatric patients infected by SARS CoV 2 Studies concerning Severe Acute Respiratory Syndrome Coronavirus 2 SARS CoV 2 infection in paediatrics are limited to children mainly selected from hospitals where patients with complications and co morbidities are managed We aimed to describe the course of the Coronavirus Disease 2019 COVID 19 in a population of children enrolled by place of residence from diagnosis to recovery with a long term clinical and serological follow up We identified patients aged 14 years old living in the Turin Health District 3 who had SARS CoV 2 detected in at least one nasopharyngeal swab from 1st March to 1st June 2020 Epidemiological and clinical features of SARS CoV 2 infection were collected by way of a telephone inquiry Enrolled patients were tested for SARS CoV 2 serology in order to provide evidence of seroconversion and persistence of specific antibodies some time after the infection A total of 46 patients with SARS CoV 2 infection COVID 19 were identified The main pattern of viral transmission was intra family Eleven children were totally asymptomatic If symptoms appeared the disease had a mild course A single case of COVID 19 related respiratory insufficiency was registered Among children who underwent serological evaluation 84 had seroconversion No significant differences in antibody development were found according to the age and the burden of the disease Children tested farther from the primary infection had lower antibody index titre values than the others In conclusion COVID 19 has a good prognosis in paediatric age Children are able to develop a valid immune response although their index titres seem to decrease a long time after the disease 