text: Elementary Laboratory Assays as Biomarkers of Ageing Support for Treatment of COVID 19 Youth working age and the elderly On a timeline chronological age CA and biological age BA may dissociate nosological entities manifest themselves at different BAs In determining which disease corresponds to a given age decade statistical registries of causes of death are unreliable and this does not change with SARS CoV 2 infection Beyond adolescence ageing metrics involve estimations of changes in fitness including prediction models to estimate the number of remaining years left to live A substantial disparity in biomarker levels and health status of ageing can be observed the difference in CA and BA in the large cohorts under consideration is glaring Here we focus more closely on ageing and senescence metrics in order to make information available for risk analysis non the least with COVID 19 including the most recent risk factors of ABO blood type and 3p21 31 chromosome cluster impacting on C5a and SC5b 9 plasma levels From the multitude of routine medical laboratory assays a potentially meaningful set of assays aimed to best reflect the stage of individual senescence hence risk factors the observational prospective SENIORLABOR study of 1 467 healthy elderly performed since 2009 and similar approaches since 1958 can be instantiated as a network to combine a set of elementary laboratory assays quantifying senescence 