text: Sequelae persistent symptomatology and outcomes after COVID 19 hospitalization the ANCOHVID multicentre 6 month follow up study Long term effects of COVID 19 also called Long COVID affect more than 10 of patients The most severe cases i e those requiring hospitalization present a higher frequency of sequelae but detailed information on these effects is still lacking The objective of this study is to identify and quantify the frequency and outcomes associated with the presence of sequelae or persistent symptomatology SPS during the 6 months after discharge for COVID 19 Retrospective observational 6 month follow up study conducted in four hospitals of Spain A cohort of all 969 patients who were hospitalized with PCR confirmed SARS CoV 2 from March 1 to April 15 2020 was included We collected all the SPS during the 6 months after discharge reported by patients during follow up from primary care records Cluster analyses were performed to validate the measures The main outcome measures were return to the Emergency Services hospital readmission and post discharge death Surviving patients outcomes were collected through clinical histories and primary care reports Multiple logistic regression models were applied The 797 82 2 patients who survived constituted the sample followed while the rest died from COVID 19 The mean age was 63 0 years 53 7 of them were men and 509 63 9 reported some sequelae during the first 6 months after discharge These sequelae were very diverse but the most frequent were respiratory 42 0 systemic 36 1 neurological 20 8 mental health 12 2 and infectious 7 9 SPS with some differences by sex Women presented higher frequencies of headache and mental health SPS among others A total of 160 20 1 patients returned to the Emergency Services 35 4 4 required hospital readmission and 8 1 0 died during follow up The main factors independently associated with the return to Emergency Services were persistent fever dermatological SPS arrythmia or palpitations thoracic pain and pneumonia COVID 19 cases requiring hospitalization during the first wave of the pandemic developed a significant range of mid to long term SPS A detailed list of symptoms and outcomes is provided in this multicentre study Identification of possible factors associated with these SPS could be useful to optimize preventive follow up strategies in primary care for the coming months of the pandemic 