text: SARS CoV 2 and pathological matrix remodeling mediators Recognizing only sharp elevation in a short period of time the COVID 19 SARS CoV 2 propagation is more and more marked in the whole world Induced inflammation afterwards infection engenders a high infiltration of immune cells and cytokines that triggers matrix metalloproteinases MMPs activation These endopeptidases are mediators of the lung extracellular matrix ECM a basic element for alveoli structure and gas exchange When immune cells MMPs secreted cytokines and several other mediators are gathered a pathological matrix remodeling occurs This phenomenon tends to tissue destruction in the first place and a pulmonary hypertrophy and fibrosis in the second place After pathological matrix remodeling establishment pathological diseases take place even after infection state Since post COVID 19 pulmonary fibrosis is an emerging complication of the disease there is an urge to better understand and characterize the implication of ECM remodeling during SARS CoV 2 infection Targeting MMPs and their inhibitors could be a probable solution for occurred events since there are many cured patients that remain with severe sequels even after the end of infection 