text: Detection of N6 methyladenosine in SARS CoV 2 RNA by methylated RNA immunoprecipitation sequencing MeRIP Seq i N i sup i 6 i sup methylation of adenosine m6A is the most abundant internal mRNA modification and is an important post transcriptional regulator of gene expression Here we describe a protocol for methylated RNA immunoprecipitation sequencing MeRIP Seq to detect and quantify m6A modifications in severe acute respiratory syndrome coronavirus 2 SARS CoV 2 RNA The protocol is optimized for low viral RNA levels and is readily adaptable for other applications 