text: Multisystem inflammatory syndrome in children MIS C a mini review Multisystem inflammatory syndrome in children MIS C is a novel life threatening hyperinflammatory condition that develops in children a few weeks after infection with severe acute respiratory syndrome coronavirus 2 SARS CoV 2 This disease has created a diagnostic challenge due to overlap with Kawasaki disease KD and KD shock syndrome The majority of patients with MIS C present with the involvement of at least four organ systems and all have evidence of a marked inflammatory state Most patients show an increase in the level of at least four inflammatory markers C reactive protein neutrophil count ferritin procalcitonin fibrinogen interleukin 6 and triglycerides Therapy is primarily with immunomodulators suggesting that the disease is driven by post infectious immune dysregulation Most patients even those with severe cardiovascular involvement recover without sequelae Since coronary aneurysms have been reported echocardiographic follow up is needed Further study is needed to create uniform diagnostic criteria therapy and follow up protocols 