text: Long COVID syndrome associated brain fog and chemofog Luteolin to the rescue COVID 19 leads to severe respiratory problems but also to long COVID syndrome associated primarily with cognitive dysfunction and fatigue Long COVID syndrome symptoms especially brain fog are similar to those experienced by patients undertaking or following chemotherapy for cancer chemofog or chemobrain as well in patients with myalgic encephalomyelitis chronic fatigue syndrome ME CFS or mast cell activation syndrome MCAS The pathogenesis of brain fog in these illnesses is presently unknown but may involve neuroinflammation via mast cells stimulated by pathogenic and stress stimuli to release mediators that activate microglia and lead to inflammation in the hypothalamus These processes could be mitigated by phytosomal formulation in olive pomace oil of the natural flavonoid luteolin 