text: SARS CoV 2 Neuronal Invasion and Complications Potential Mechanisms and Therapeutic Approaches Clinical reports suggest that the coronavirus disease 19 COVID 19 pandemic caused by severe acute respiratory syndrome SARS coronavirus 2 CoV 2 has not only taken millions of lives but has also created a major crisis of neurologic complications that persist even after recovery from the disease Autopsies of patients confirm the presence of the coronaviruses in the CNS especially in the brain The invasion and transmission of SARS CoV 2 in the CNS is not clearly defined but because the endocytic pathway has become an important target for the development of therapeutic strategies for COVID 19 it is necessary to understand endocytic processes in the CNS In addition mitochondria and mechanistic target of rapamycin mTOR signaling pathways play a critical role in the antiviral immune response and may also be critical for endocytic activity Furthermore dysfunctions of mitochondria and mTOR signaling pathways have been associated with some high risk conditions such as diabetes and immunodeficiency for developing severe complications observed in COVID 19 patients However the role of these pathways in SARS CoV 2 infection and spread are largely unknown In this review we discuss the potential mechanisms of SARS CoV 2 entry into the CNS and how mitochondria and mTOR pathways might regulate endocytic vesicle mitochondria interactions and dynamics during SARS CoV 2 infection The mechanisms that plausibly account for severe neurologic complications with COVID 19 and potential treatments with Food and Drug Administration approved drugs targeting mitochondria and the mTOR pathways are also addressed 