text: The psychopathological impact of the SARS CoV 2 epidemic on subjects suffering from different mental disorders An observational retrospective study SARS CoV 2 infection causes a pulmonary disease COVID 19 which spread worldwide generating fear anxiety depression in the general population as well as among subjects affected by mental disorders Little is known about which different psychopathological changes the pandemic caused among individuals affected by different psychiatric disorders which represents the aim of the present study Specific psychometric scales were administered at three time points T0 as outbreak of pandemic T1 as lockdown period T2 as reopening Descriptive analyses and linear regression models were performed A total of 166 outpatients were included Overall psychometric scores showed a significant worsening at T1 with a mild improvement at T2 Only psychopathology in schizophrenia SKZ patients and obsessive compulsive OC symptoms did not significantly improve at T2 Subjects affected by personality disorders PDs resulted to be more compromised in terms of general psychopathology than depressed and anxiety OC ones and showed more severe anxiety symptoms than SKZ patients In conclusion subjects affected by PDs require specific clinical attention during COVID 19 pandemic Moreover the worsening of SKZ and OC symptoms should be strictly monitored by clinicians as these aspects did not improve with the end of lockdown measures Further studies on larger samples are needed to confirm our results ClinicalTrials gov Identifier NCT04694482 