text: Association of Blood Groups with the Severity and Outcome of COVID 19 Infection in Children The objective of this study was to find out the association of ABO blood groups with the severity and outcome of corona virus disease 2019 COVID 19 in children It included all laboratory confirmed cases of COVID 19 and post COVID multisystem inflammatory syndrome in children MIS C Kawasaki disease KD like illness admitted from March to September 2020 to The Childrens Hospital Lahore Out of 66 children 45 68 2 were COVID 19 and 21 31 8 MIS C KD temporally associated with SARS C0V 2 The mean age was 7 9 4 2 years Majority of children had mild to moderate illness 38 57 6 while 23 34 8 had severe or critical disease Among all patients 24 36 4 had some underlying comorbidity Blood group A was significantly associated with severe and critical disease p 0 030 COVID 19 in children had generally a good outcome but children with blood group A were more susceptible to severe critical disease Key Words Coronavirus disease 2019 ABO blood groups Children Severity Outcome 