text: Post COVID syndrome a new challenge for medicine The huge concern raised by SARS CoV2 pandemic about public health management and social impact is still under debate particularly because COVID 19 may affect infected people much longer than expected from a typical air borne viral disease The scientific community is actually wondering about the etiopathogenesis and clinical development of this post COVID complex symptomatology very close to symptoms typically observed in chronic fatigue syndrome so recently named as post acute sequelae of COVID 19 PASC This commentary tries to focus on the most recent news about this issue 