text: Identification of homologous human miRNAs as antivirals towards COVID 19 genome The COVID 19 fatality rate is 57 worldwide The investigation of possible antiviral therapy using host microRNA miRNA to inhibit viral replication and transmission is the need of the hour Computational techniques were used to predict the hairpin precursor miRNA pre miRNAs of COVID 19 genome with high homology towards human host miRNA Top 21 host miRNAs with 80 homology towards 18 viral pre miRNAs were identified The Gibbs free energy ΔG between host miRNAs and viral pre miRNAs hybridization resulted in the best 5 host miRNAs having the highest base pair complementarity miR 4476 had the strongest binding with viral pre miRNA ΔG 21 8 kcal mol due to maximum base pairing in the seed sequence Pre miR 651 secondary structure was most stable due to the 1 least minimum free energy ΔG 24 4 kcal mol energy frequency and noncanonical base pairing and 2 maximum number of stem base pairing and small loop size Host miRNAs viral mRNAs interaction can effectively inhibit viral transmission and replication Furthermore miRNAs gene network and gene ontology studies indicate top 5 host miRNAs interaction with host genes involved in transmembrane receptor signaling cell migration RNA splicing nervous system formation and tumor necrosis factor mediated signaling in respiratory diseases This study identifies host miRNA virus pre miRNAs strong interaction structural stability and their gene network analysis provides strong evidence of host miRNAs as antiviral COVID 19 agents 