text: Severe acute respiratory syndrome coronavirus 2 related multisystem inflammatory syndrome in children mimicking Kawasaki disease The severe acute respiratory syndrome coronavirus 2 SARS CoV 2 pandemic has been characterized by high transmission rates and high mortality in adults with predisposing factors including age 70 years obesity diabetes systemic hypertension and other underlying diseases During the second week of viral pneumonia acute respiratory distress syndrome can occur and carries high mortality Unlike most common respiratory viruses children seem to be less susceptible to SARS CoV 2 infection and generally develop mild disease with low mortality However clusters of severe shock associated with high levels of cardiac biomarkers and unusual vasoplegia requiring inotropes vasopressors and volume loading have recently been described Both the clinical symptoms i e high and persistent fever gastrointestinal disorders skin rash conjunctival injection and dry cracked lips and the biological signs e g elevated C reactive protein procalcitonin and high levels of ferritinaemia mimicked Kawasaki disease In most cases intravenous immunoglobin therapy improved cardiac function and led to full recovery within a few days Adjunctive steroid therapy and sometimes biotherapy e g anti interleukin 1Ra and anti interleukin 6 monoclonal antibodies were often necessary Although almost all children fully recovered within a week some of them later developed coronary artery dilation or aneurysm Thus a new multisystem inflammatory syndrome in children related to SARS CoV 2 has recently been described Similarities with Kawasaki disease and the physiopathology of this syndrome still need further exploration 