text: COVID Related Stress and Work Intentions in a Sample of US Health Care Workers To evaluate relationships between coronavirus disease 2019 COVID 19 related stress and work intentions in a sample of US health care workers Between July 1 and December 31 2020 health care workers were surveyed for fear of viral exposure or transmission COVID 19 related anxiety or depression work overload burnout and intentions to reduce hours or leave their jobs Among 20 665 respondents at 124 institutions median organizational response rate 34 intention to reduce hours was highest among nurses 33 7 n 776 physicians 31 4 n 2914 and advanced practice providers APPs 28 9 n 608 while lowest among clerical staff 13 6 n 242 and administrators 6 8 n 50 all i P i 001 Burnout odds ratio OR 2 15 95 CI 1 93 to 2 38 fear of exposure COVID 19 related anxiety depression and workload were independently related to intent to reduce work hours within 12 months all i P i 01 Intention to leave ones practice within 2 years was highest among nurses 40 0 n 921 APPs 33 0 n 694 other clinical staff 29 4 n 718 and physicians 23 8 n 2204 while lowest among administrators 12 6 n 93 all i P i 001 Burnout OR 2 57 95 CI 2 29 to 2 88 fear of exposure COVID 19 related anxiety depression and workload were predictors of intent to leave Feeling valued by ones organization was protective of reducing hours OR 0 65 95 CI 0 59 to 0 72 and intending to leave OR 0 40 95 CI 0 36 to 0 45 all i P i 01 Approximately 1 in 3 physicians APPs and nurses surveyed intend to reduce work hours One in 5 physicians and 2 in 5 nurses intend to leave their practice altogether Reducing burnout and improving a sense of feeling valued may allow health care organizations to better maintain their workforces postpandemic 