text: Metabolic Reprogramming in COVID 19 Plenty of research has revealed virus induced alternations in metabolic pathways which is known as metabolic reprogramming Studies focusing on COVID 19 have uncovered significant changes in metabolism resulting in the perspective that COVID 19 is a metabolic disease Reprogramming of amino acid glucose cholesterol and fatty acid is distinctive characteristic of COVID 19 infection These metabolic changes in COVID 19 have a critical role not only in producing energy and virus constituent elements but also in regulating immune response offering new insights into COVID 19 pathophysiology Remarkably metabolic reprogramming provides great opportunities for developing novel biomarkers and therapeutic agents for COVID 19 infection Such novel agents are expected to be effective adjuvant therapies In this review we integrate present studies about major metabolic reprogramming in COVID 19 as well as the possibility of targeting reprogrammed metabolism to combat virus infection 