text: Stop COVID Cohort An Observational Study of 3480 Patients Admitted to the Sechenov University Hospital Network in Moscow City for Suspected Coronavirus Disease 2019 COVID 19 Infection The epidemiology clinical course and outcomes of patients with coronavirus disease 2019 COVID 19 in the Russian population are unknown Information on the differences between laboratory confirmed and clinically diagnosed COVID 19 in real life settings is lacking We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID 19 infection in Moscow between 8 April and 28 May 2020 Of the 4261 patients hospitalized for suspected COVID 19 outcomes were available for 3480 patients median age 56 years interquartile range 45 66 The most common comorbidities were hypertension obesity chronic cardiovascular disease and diabetes Half of the patients n 1728 had a positive reverse transcriptase polymerase chain reaction RT PCR while 1748 had a negative RT PCR but had clinical symptoms and characteristic computed tomography signs suggestive of COVID 19 No significant differences in frequency of symptoms laboratory test results and risk factors for in hospital mortality were found between those exclusively clinically diagnosed or with positive severe acute respiratory syndrome coronavirus 2 SARS CoV 2 RT PCR In a multivariable logistic regression model the following were associated with in hospital mortality older age per 1 year increase odds ratio 1 05 95 confidence interval 1 03 1 06 male sex 1 71 1 24 2 37 chronic kidney disease 2 99 1 89 4 64 diabetes 2 1 1 46 2 99 chronic cardiovascular disease 1 78 1 24 2 57 and dementia 2 73 1 34 5 47 Age male sex and chronic comorbidities were risk factors for in hospital mortality The combination of clinical features was sufficient to diagnose COVID 19 infection indicating that laboratory testing is not critical in real life clinical practice 