text: Will Nothing Be the Same Again Changes in Lifestyle during COVID 19 Pandemic and Consequences on Mental Health Social isolation caused by the COVID 19 pandemic has drastically affected lifestyles from sedentary behaviors to reduced physical activity from disrupted sleep patterns to altered dietary habits As a consequence serious mental and emotional responses have been registered There was a significant decline in physical and other meaningful activities of daily living leisure social activity and education In children collateral effects of the pandemic include inadequate nutrition with a risk of both overweight and underweight addiction to screens lack of schooling and psychosocial difficulties Older adults are frequently unable to adapt to lockdown measures and suffer from depression and cognitive complaints Recent studies focusing on changes in lifestyle during the Covid 19 pandemic and consequences on mental health have been identified in PubMed Medline Scopus Embase and ScienceDirect All the available literature has been retrospectively reviewed The results of the present narrative review suggest that mental distress caused by social isolation seems to be linked not only to personality characteristics but also to several lifestyle components sleep disruption altered eating habits reduced physical activity This review aims to explore major changes in the lifestyle and quality of life and the impact of these changes on mental health and to inform clinicians and policymakers about elements that may reduce the negative psychological effects of the quarantine period imposed during this worldwide crisis There is an urgent need for tailored preventive diagnostic and therapeutic mental health interventions for the general population and for higher risk groups 