text: Comparison of in house SARS CoV 2 genome extraction procedures A need for COVID 19 pandemic Among the methods used to diagnose COVID 19 those based on genomic detection by q RT PCR are the most sensitive To perform these assays a previous genome extraction of the sample is required The dramatic increase in the number of SARS CoV 2 detection assays has increased the demand for extraction reagents hindering the supply of commercial reagents Homemade reagents and procedures could be an alternative Nasopharyngeal samples were extracted by seven different methods as well as the automatic method MagNaPure96 to detect SARS CoV 2 All protocols show sensitivity higher than 87 in comparison with reference method for detecting SARS CoV 2 as well as human β globin Our results support that these procedures using common and cheap reagents are effective to extract RNA from SARS CoV 2 or DNA from human β globin genome from nasopharyngeal swabs Furthermore these procedures could be easily adopted by routine diagnostic laboratories to implement detection methods to help to fight against COVID 19 pandemic 