text: Burdens of post acute sequelae of COVID 19 by severity of acute infection demographics and health status The Post Acute Sequelae of SARS CoV 2 infection PASC have been characterized however the burden of PASC remains unknown Here we used the healthcare databases of the US Department of Veterans Affairs to build a cohort of 181 384 people with COVID 19 and 4 397 509 non infected controls and estimated that burden of PASC defined as the presence of at least one sequela in excess of non infected controls was 73 43 72 10 74 72 per 1000 persons at 6 months Burdens of individual sequelae varied by demographic groups age race and sex but were consistently higher in people with poorer baseline health and in those with more severe acute infection In sum the burden of PASC is substantial PASC is non monolithic with sequelae that are differentially expressed in various population groups Collectively our results may be useful in informing health systems capacity planning and care strategies of people with PASC 