text: The Neurological Manifestations of Post Acute Sequelae of SARS CoV 2 infection Coronavirus disease 2019 COVID 19 caused by the severe acute respiratory syndrome coronavirus 2 SARS CoV 2 is a global health challenge This review aims to summarize the incidence risk factors possible pathophysiology and proposed management of neurological manifestations of post acute sequelae of SARS CoV 2 infection PASC or neuro PASC based on the published literature The National Institutes of Health has noted that PASC is a multi organ disorder ranging from mild symptoms to an incapacitating state that can last for weeks or longer following recovery from initial infection with SARS CoV 2 Various pathophysiological mechanisms have been proposed as the culprit for the development of PASC These include but are not limited to direct or indirect invasion of the virus into the brain immune dysregulation hormonal disturbances elevated cytokine levels due to immune reaction leading to chronic inflammation direct tissue damage to other organs and persistent low grade infection A multidisciplinary approach for the treatment of neuro PASC will be required to diagnose and address these symptoms Tailored rehabilitation and novel cognitive therapy protocols are as important as pharmacological treatments to treat neuro PASC effectively With recognizing the growing numbers of COVID 19 patients suffering from neuro PASC there is an urgent need to identify affected individuals early to provide the most appropriate and efficient treatments Awareness among the general population and health care professionals about PASC is rising and more efforts are needed to understand and treat this new emerging challenge In this review we summarize the relevant scientific literature about neuro PASC 