text: Short term and Long term Rates of Postacute Sequelae of SARS CoV 2 Infection A Systematic Review Short term and long term persistent postacute sequelae of COVID 19 PASC have not been systematically evaluated The incidence and evolution of PASC are dependent on time from infection organ systems and tissue affected vaccination status variant of the virus and geographic region To estimate organ system specific frequency and evolution of PASC PubMed MEDLINE Scopus the World Health Organization Global Literature on Coronavirus Disease and CoronaCentral databases were searched from December 2019 through March 2021 A total of 2100 studies were identified from databases and through cited references Studies providing data on PASC in children and adults were included The Preferred Reporting Items for Systematic Reviews and Meta analyses PRISMA guidelines for abstracting data were followed and performed independently by 2 reviewers Quality was assessed using the Newcastle Ottawa Scale for cohort studies The main outcome was frequency of PASC diagnosed by 1 laboratory investigation 2 radiologic pathology and 3 clinical signs and symptoms PASC were classified by organ system ie neurologic cardiovascular respiratory digestive dermatologic and ear nose and throat as well as mental health constitutional symptoms and functional mobility From a total of 2100 studies identified 57 studies with 250 351 survivors of COVID 19 met inclusion criteria The mean SD age of survivors was 54 4 8 9 years 140 196 56 were male and 197 777 79 were hospitalized during acute COVID 19 High income countries contributed 45 studies 79 The median IQR proportion of COVID 19 survivors experiencing at least 1 PASC was 54 0 45 0 69 0 13 studies at 1 month short term 55 0 34 8 65 5 38 studies at 2 to 5 months intermediate term and 54 0 31 0 67 0 9 studies at 6 or more months long term Most prevalent pulmonary sequelae neurologic disorders mental health disorders functional mobility impairments and general and constitutional symptoms were chest imaging abnormality median IQR 62 2 45 8 76 5 difficulty concentrating median IQR 23 8 20 4 25 9 generalized anxiety disorder median IQR 29 6 14 0 44 0 general functional impairments median IQR 44 0 23 4 62 6 and fatigue or muscle weakness median IQR 37 5 25 4 54 5 respectively Other frequently reported symptoms included cardiac dermatologic digestive and ear nose and throat disorders In this systematic review more than half of COVID 19 survivors experienced PASC 6 months after recovery The most common PASC involved functional mobility impairments pulmonary abnormalities and mental health disorders These long term PASC effects occur on a scale that could overwhelm existing health care capacity particularly in low and middle income countries 