text: Immune mediating molecules and pathogenesis of COVID 19 associated neurological disease Long period of SARS CoV 2 infection has been associated with psychiatric and cognitive disorders in adolescents and children SARS CoV 2 remains dormant in the CNS leading to neurological complications The wide expression of ACE2 in the brain raises concern for its involvement in SARS CoV 2 infection Though the mechanistic insights about blood brain barriers BBB crossing by SARS CoV 2 and further brain infection are still not clear Moreover the mechanism behind dormant SARS CoV 2 infections leading to chronic neurological disorders needs to be unveiled There is an urgent need to find out the risk factor involved in COVID 19 associated neurological disease Therefore the role of immune associated genes in the pathogenesis of COVID 19 associated neurological diseases is presented which could contribute to finding associated genetic risk factors The search utilizing multiple databases specifically EMBASE PubMed Medline and Google Scholar was performed Moreover the literature survey on the involvement of COVID 19 neuropathogenesis and its consequences was done Persistent inflammatory stimuli may promote the progression of neurodegenerative diseases An increased expression level of cytokine chemokine and decreased expression level of immune cells has been associated with the COVID 19 patient Cytokine storm was observed in severe COVID 19 patients The nature of SARS CoV 2 infection can be neuroinflammatory Genes of immune response could be associated with neurodegenerative diseases The present review will provide a useful framework and help in understanding COVID 19 associated neuropathogenesis Experimental studies on immune associated genes in COVID 19 patients with neurological manifestations could be helpful to establish its neuropathogenesis 