text: Post COVID Syndrome Incidence Clinical Spectrum and Challenges for Primary Healthcare Professionals Post COVID syndrome also known as long COVID refers to symptoms persisting for more than three weeks after the diagnosis of COVID 19 We reviewed the current evidence on post COVID syndrome focusing on its clinical manifestations and addressing the challenges for its management in primary healthcare The incidence of post COVID syndrome is estimated at 10 35 while for hospitalized patients it may reach 85 Fatigue is the most common symptom reported in 17 5 72 of post COVID cases followed by residual dyspnea with an incidence ranging from 10 40 Mental problems chest pain and olfactory and gustatory dysfunction may affect up to 26 22 and 11 of patients respectively More than one third of patients with post COVID syndrome have pre existing comorbidities hypertension and diabetes mellitus being the most common Beyond the prolonged duration of symptoms the scarce published data indicate that most patients with post COVID syndrome have a good prognosis with no further complications or fatal outcomes reported Given the clinical spectrum of patients with post COVID syndrome most of them will be managed by primary healthcare professionals in conjunction with pre existing or new co morbidities which in turn may increase the burden of COVID 19 on primary healthcare In conclusion approximately 10 of patients with COVID 19 may have symptoms persisting beyond three weeks fulfilling the criteria of post COVID syndrome Primary healthcare professionals have a key role in the management of patients with post COVID syndrome Research is needed to elucidate the pathogenesis clinical spectrum and prognosis of post COVID syndrome 