text: The authors present an end to end training of a CNN architecture that combines CT image signal processing and image analysis.  This is an interesting paper.  Time will tell whether a disease specific signal processing will be the future of medical image analysis,  but - to the best of my knowledge - this is one of the first attempts to do this in CT image analysis,  a field that is of significance both to researchers dealing with image reconstruction (denoising, etc.) and image analysis (lesion detection).   As such I would be positive about the topic of the paper and the overall innovation it promises both in image acquisition and image processing,  although I would share the technical concerns pointed out by Reviewer2,  and the authors would need good answers to them before this study would be ready to be presented.