diff --git "a/descriptions/corpus.jsonl" "b/descriptions/corpus.jsonl" --- "a/descriptions/corpus.jsonl" +++ "b/descriptions/corpus.jsonl" @@ -1,3229 +1,3229 @@ -{"_id": 2, "text": "A cerebral ventricle cancer that is located_in the plexus located_in the ventricles of the brain."} -{"_id": 5, "text": "An angiosarcoma and hemangioma of intra-abdominal structure and malignant soft tissue neoplasm of the spleen that results_in a nonhematolymphoid malignant neoplasm of the spleen."} -{"_id": 8, "text": "A endometrial cancer that is located_in the tissue lining the uterus."} -{"_id": 11, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia."} -{"_id": 14, "text": "An inherited metabolic disorder that involves mitochondrial metabolism dysfunction."} -{"_id": 17, "text": "A non-syndromic intellectual disability characterized by a X-linked inheritance pattern."} -{"_id": 20, "text": "An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infection."} -{"_id": 23, "text": "A tularemia that results_in inflammation of eye and swelling of lymph glands in front of the ear."} -{"_id": 26, "text": "A opisthorchiasis that involves parasitic infection of the liver, biliary ducts, pancreas and pancreatic ducts by Opisthorchis felineus. The symptoms include fever, general malaise, skin rash, gastrointestinal disturbances, severe anemia and liver damage."} -{"_id": 29, "text": "A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing."} -{"_id": 32, "text": "An ectothrix infectious disease that results_in zoophilic fungal infection located_in hair, located_in skin, and located_in nail, has_material_basis_in Microsporum canis."} -{"_id": 35, "text": "A genetic disease associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia."} -{"_id": 38, "text": "A commensal Escherichia coli infectious disease that is caused by Escherichia coli. The disease results from proliferation of aspirated organisms in terminal airways, usually at multiple sites in the lung. Multifocal area of consolidation result and terminal airways and alveoli are filled with proteinaceous fluid, fibrin, neutrophils, and macrophages."} -{"_id": 41, "text": "An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries."} -{"_id": 44, "text": "A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye."} -{"_id": 47, "text": "An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision."} -{"_id": 50, "text": "A muscle tissue disease characterized by congenital joint contractures of hand and feet."} -{"_id": 53, "text": "A purpura characterized blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation. It is often fatal."} -{"_id": 56, "text": "A smallpox that results_in severe infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions."} -{"_id": 59, "text": "An autosomal dominant disease that is characterized by predisposition to hamartomatous benign polyps in the gastrointestinal tract, specifically in the stomach, small intestine, colon, and rectum."} -{"_id": 62, "text": "A Human immunodeficiency virus infectious disease that results_in inflammation located_in wall of artery of the central nervous system, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2."} -{"_id": 65, "text": "An autosomal dominant disease characterized by abnormalities of the front part of the eye, the anterior segment."} -{"_id": 68, "text": "A breast myoepithelial neoplasm that affects the breast and is characterized by biphasic proliferation of both epithelial and myoepithelial cells."} -{"_id": 71, "text": "A genetic disease that is characterized by underdevelopment of the tips of fingers or toes, underdevelopment or abscense of finger or toe nails and developmental disability."} -{"_id": 74, "text": "A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinomycetales bacteria, which are part of the normal human flora."} -{"_id": 77, "text": "A spotted fever that has_material_basis_in Rickettsia rickettsii, which is transmitted_by ticks (Dermacentor variabilis and Dermacentor andersoni). The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, and has_symptom maculopapular rash progressing into papular or petechial rash."} -{"_id": 80, "text": "A viral infectious disease that results_in infection in pigs, has_material_basis_in African swine fever virus, which is transmitted_by contact with sick animals or transmitted_by ingestion of contaminated food containing infected meat, or transmitted_by ticks of the genus Ornithodoros. The infection has_symptom fever, has_symptom reddening of the skin, has_symptom leukopenia, and has_symptom thrombocytopenia."} -{"_id": 83, "text": "An X-linked disease that is caused by mutation in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement."} -{"_id": 86, "text": "A connective tissue benign neoplasm that is located_in bone."} -{"_id": 89, "text": "A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term."} -{"_id": 92, "text": "A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both."} -{"_id": 95, "text": "A duodenum cancer that derives_from epithelial cells of glandular origin."} -{"_id": 98, "text": "A acute conjunctivitis which involves a fibrin-rich exudate formation on the surface of the conjunctiva. Infectious causes of pseudomembranes include Corynebacterium diphtheriae, streptococci, pneumococci, herpes simplex virus, adenovirus, Chlamydia and gonococci. Other causes include chemical (alkali) irritants, erythema multiforme, and ocular pemphigoid."} -{"_id": 101, "text": "A plasma protein metabolism disease that has_material_basis_in defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells."} -{"_id": 104, "text": "A ethmoid sinusitis which lasts for 12 weeks or more."} -{"_id": 107, "text": "A viral infectious disease that results_in necrosis located_in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has_symptom severe chest pain, has_symptom fever, has_symptom malaise, has_symptom pleuritis, and has_symptom headache."} -{"_id": 110, "text": "A pneumonia which has a multifactorial etiology and develops as a result of complex interactions between environmental factors, host factors, and pathogens leading to pulmonary lesions caused by various micro organisms ( essentially viruses and bacteria). Environmental factors (eg, weaning, transport, commingling, crowding, and inadequate ventilation) serve as stressors that adversely affect the immune and nonimmune defense mechanisms of the host. In addition, certain environmental factors (eg, crowding and inadequate ventilation) can enhance the transmission of infectious agents among animals."} -{"_id": 113, "text": "An arthritis that has_material_basis_in uric acid crystal deposits located_in joint."} -{"_id": 116, "text": "A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection."} -{"_id": 119, "text": "A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems."} -{"_id": 122, "text": "A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions."} -{"_id": 125, "text": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells."} -{"_id": 128, "text": "An inflammatory bowel disease characterized by inflammation located_in colon only, has_symptom diarrhea, has_symptom rectal bleeding, has_symptom skin lesions and has_symptom formation of ulcers, fistulas and abscesses around the anus."} -{"_id": 131, "text": "A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting."} -{"_id": 134, "text": "A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding."} -{"_id": 137, "text": "A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands."} -{"_id": 140, "text": "A muscular disease in which the muscle fibers do not function resulting in muscular weakness."} -{"_id": 143, "text": "A labyrinthitis which is a bacterial infectious disease of the inner ear, often causing deafness and loss of vestibular function. This is caused when bacteria spread to the inner ear during the course of severe acute otitis media, purulent meningitis, or an enlarging cholesteatoma."} -{"_id": 146, "text": "A uterine Corpus sarcoma that has recurred after it has been treated."} -{"_id": 149, "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from precursor cells called blast cells."} -{"_id": 152, "text": "An agnosia that is a loss of the ability to orient parts of the body."} -{"_id": 155, "text": "A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation."} -{"_id": 158, "text": "An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy."} -{"_id": 161, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Echinostoma species. The symptoms include nausea, vomiting, diarrhea, fever and abdominal pain."} -{"_id": 164, "text": "A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation."} -{"_id": 167, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop."} -{"_id": 170, "text": "A West Nile virus infectious disease that has_material_basis_in West Nile virus, which can cause meningitis, encephalitis, acute laccid paralysis, Parkingsonian-like conditions or movement disorder."} -{"_id": 173, "text": "A heart sarcoma that is a soft tissue sarcoma located in the heart."} -{"_id": 176, "text": "A medulloblastoma that is characterized by cells that are larger than would be normally expected."} -{"_id": 179, "text": "An epidemic typhus that is a mild form of the disease, which recurs in someone after a long period of latency due to immunosuppression, malnutrition or other illnesses."} -{"_id": 182, "text": "A mixed germ cell cancer that is located_in the testis."} -{"_id": 185, "text": "A peripheral primitive neuroectodermal tumor that is located_in bone."} -{"_id": 188, "text": "An organ system benign neoplasm located_in the integumentary system organs."} -{"_id": 191, "text": "An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur."} -{"_id": 194, "text": "A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue."} -{"_id": 197, "text": "A vein disease that is characterized by impaired flow of blood through the veins."} -{"_id": 200, "text": "An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms."} -{"_id": 203, "text": "A peripheral neuropathy that involves damage to nerves of the peripheral nervous system."} -{"_id": 206, "text": "A syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows, medially flaring and sparse in the middle part, hypertelorism, deep set but large eyes, large and uplifted ear lobes, with a central depression, saddle nose with prominent rounded nasal tip, prominent columella, open mouth, with M-shaped upper lip, frequent smiling, and a prominent but narrow and triangular pointed chin), moderate-to-severe intellectual deficiency, epilepsy and variable congenital malformations including Hirschsprung disease, genitourinary anomalies (in particular hypospadias in males), congenital heart defects, agenesis of the corpus callosum and eye anomalies. It is caused by de novo heterozygous mutation in the ZEB2 gene on chromosome 2q22."} -{"_id": 209, "text": "A pancreas disease that is characterized by the failure of the pancreas to develop prior to birth."} -{"_id": 212, "text": "An American histoplasmosis that results_in inflammation, located_in stomach lining in immunocompromised patients, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and results_in_formation_of gastric mass with ulceration, and results_in_formation_of hypertrophic gastric folds."} -{"_id": 215, "text": "A renal tubular transport disease characterized by excess levels of acid in the blood, due to a failure of the kidneys to appropriately acidify the urine."} -{"_id": 218, "text": "A brucellosis that involves an infection caused by Brucella melitensis in cattle, goats, sheep and humans. The disease has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom limb pain and has_symptom back pain."} -{"_id": 221, "text": "A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades."} -{"_id": 224, "text": "An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain."} -{"_id": 227, "text": "A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes."} -{"_id": 230, "text": "A head and neck cancer that has_material_basis_in epithelial cells and is located_in the upper aerodigestive tract, including the lip, oral cavity (mouth), nasal cavity, paranasal sinuses, pharynx, and larynx."} -{"_id": 233, "text": "A kidney sarcoma that starts in the bones and that is located_in the kidney."} -{"_id": 236, "text": "A Coronaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Torovirus, which is transmitted_by ingestion of food contaminated with feces."} -{"_id": 239, "text": "An agnosia that is a loss of the ability to recgonize a whole image or scene while retianing the ability to recognize objects or details in their visual field one at a time."} -{"_id": 242, "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice."} -{"_id": 245, "text": "A speech disorder that involves a complete inability to speak."} -{"_id": 248, "text": "A fish allergy triggered by Salmo salar."} -{"_id": 251, "text": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells."} -{"_id": 254, "text": "An esophageal carcinoma that derives_from epithelial cells of the salivary gland."} -{"_id": 257, "text": "A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination."} -{"_id": 260, "text": "An endodermal sinus tumor that occurs in children."} -{"_id": 263, "text": "A ssDNA virus infectious disease that results_in infection in humans, has_material_basis_in Anelloviridae viruses."} -{"_id": 266, "text": "A papillomavirus infectious disease and complicated_by acquired immunodeficiency syndrome that results_in infection, has_material_basis_in human papillomavirus, in patients with AIDS."} -{"_id": 269, "text": "A Measles virus infectious disease that results_in inflammation located_in cornea and located_in conjunctiva, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom mucopurulent discharge from the eye, has_symptom pain in the eye, and has_symptom redness."} -{"_id": 272, "text": "A sweat gland neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland."} -{"_id": 275, "text": "An amino acid metabolic disorder characterized by the formation 2,8-dihydroxyadenine stones and renal failure secondary to intratubular crystalline precipitation. It has an autosomal recessive inheritance pattern."} -{"_id": 278, "text": "A filariasis that involves parasitic infection of the abdomen in cattle, horses and sheep by nematodes of the genus Setaria."} -{"_id": 281, "text": "A human papillomavirus related carcinoma that results_in infection, has_material_basis_in human papillomavirus (types 16, or 18), which cause malignant tumors in squamous epithelium in genital and periungual areas."} -{"_id": 284, "text": "A severe combined immunodeficiency that is a X-linked SCID caused by mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells."} -{"_id": 287, "text": "A pneumonia that results_in inflammation located_in lung, has_material_basis_in Histoplasma capsulatum var capsulatum or Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom mediastinal lymphadenopathy, has_symptom cough and has_symptom chest pain."} -{"_id": 290, "text": "A sleeping sickness that involves infection caused by Trypanosoma brucei gambiense, which is carried by the tsetse fly. The symptoms include fever, rash, swelling of the face and hands, headaches, fatigue, aching muscles and joints, itching skin, swollen lymph nodes, progressive confusion, personality changes, daytime sleepiness with nighttime sleep disturbances, and other neurologic problems."} -{"_id": 293, "text": "A thrombophlebitis that is characterized by repeated occurances of thrombophlebitis in different locations."} -{"_id": 296, "text": "A spotted fever that has_material_basis_in Rickettsia helvetica, which is transmitted_by ticks (Ixodes sp). The infection has_symptom fever, has_symptom headache, has_symptom myalgia."} -{"_id": 299, "text": "An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance."} -{"_id": 302, "text": "A Cytomegalovirus infectious disease that results_in inflammation located_in stomach lining, has_material_basis_in Human herpesvirus 5, has_symptom dyspepsia, and has_symptom nausea and vomiting."} -{"_id": 305, "text": "A melanoma that is most commonly located_in sun-exposed skin and results_in_formation_ of spindle-like shaped cells that have a high recurrence rate even with treatment."} -{"_id": 308, "text": "An encephalitis that involves inflammation of the brain caused by viral infection."} -{"_id": 311, "text": "A Varicellovirus infectious disease that results_in inflammation located_in liver, has_material_basis_in Human herpesvirus 3, has_symptom skin rash, has_symptom oral lesions, has_symptom severe abdominal and back pain, has_symptom fever, has_symptom chills, has_symptom malaise, and has_symptom fatigue."} -{"_id": 314, "text": "A sleeping sickness that involves infection caused by Trypanosoma brucei rhodesiense, which is carried by the tsetse fly. The symptoms include fever, severe headache, irritability, extreme fatigue, swollen lymph nodes, aching muscles and joints, skin rash, progressive confusion, personality changes, and other neurologic problems."} -{"_id": 317, "text": "A hypersensitivity reaction type IV disease that results from the presence of excessive amounts of a single monoclonal gammaglobulin in the blood."} -{"_id": 320, "text": "An impetigo that is characterized as a form of severe pustular psoriasis occurring in pregnancy."} -{"_id": 323, "text": "A viral infectious disease that results_in infection in deer, has_material_basis_in Epizootic hemorrhagic disease virus, which is transmitted_by Culicoides biting midges. The infection has_symptom hemorrhages in many tissues including the skin, heart, and gastrointestinal tract, and has_symptom ulcers of the tongue, dental pad, palate, rumen, and omasum."} -{"_id": 326, "text": "A specific developmental disorder that is characterized by repeated, rhythmic, purposeless movements or activities such as head banging, nail biting, or body rocking."} -{"_id": 329, "text": "A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans."} -{"_id": 332, "text": "A male reproductive organ cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is_located_in the Littre glands."} -{"_id": 335, "text": "A Varicellovirus infectious disease that results_in infection located_in eye, has_material_basis_in Human herpesvirus 3, which reactivates from the trigeminal ganglion after the primary infection."} -{"_id": 338, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected."} -{"_id": 341, "text": "A bile duct disease that is an inflammation of the bile duct."} -{"_id": 344, "text": "A personality disorder that involves an excessive preoccupation with issues of personal adequacy, power, prestige and vanity."} -{"_id": 347, "text": "An impulse control disorder that involves the uncontrollable impulse to repeatedly set fires with no obvious motive."} -{"_id": 350, "text": "An African histoplasmosis that results_in inflammation located_in pericardium, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom pleural effusions, has_symptom chest pain and has_symptom cough."} -{"_id": 353, "text": "An intestinal disease located_in the cecum."} -{"_id": 356, "text": "A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix."} -{"_id": 359, "text": "A Pasteurella infectious disease that involves infection by the bacterium Mannheimia haemolytica and less frequently by Pasteurella multocida and Histophilus somni. After stress or viral infection, the replication rate of M. haemolytica in the upper respiratory tract increases rapidly, followed by inhalation and colonization of the lungs due to suppression of the host's defense mechanism. The bacterium produces exotoxin called leukotxin which interacts with the host's defense mechanism resulting in tissue damage with charactersistic necrosis, thrombosis, and exudation and the development of pneumonia."} -{"_id": 362, "text": "A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head."} -{"_id": 365, "text": "A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs."} -{"_id": 368, "text": "A pulmonary tuberculosis which involves inflammation of bronchi resulting in irregular circumferential bronchial wall thickening that leads to narrowed or even obstructed airways."} -{"_id": 371, "text": "An autosomal dominant disease that is characterized by short stature, sparse hair, a bulbous nasal tip and cone-shaped epiphyses (the growing ends of bones), as well as severe generalized shortening of all finger and toe bones (brachydactyly)."} -{"_id": 374, "text": "A histidine metabolism disease that involves a deficiency of the enzyme histidase."} -{"_id": 377, "text": "A Parkinson's disease caused by mutation in the parkin gene, PARK2, on chromosome 6q25.2-q27."} -{"_id": 380, "text": "A human papilloma virus related cervical squamous cell carcinoma that results_in infection located_in cervix, has_material_basis_in human papillomavirus (types 16 or 18), which cause papillae in squamous epithelium of cervix."} -{"_id": 383, "text": "A systemic mycosis that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices."} -{"_id": 386, "text": "An organic acidemia that disrupts or prevents normal metabolism of the branched-chain amino acid leucine."} -{"_id": 389, "text": "A cardiovascular system disease that involves the heart."} -{"_id": 392, "text": "A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell)."} -{"_id": 395, "text": "An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall."} -{"_id": 398, "text": "An immune system disease that is caused by abnormal immune responses."} -{"_id": 401, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding."} -{"_id": 404, "text": "A thyroid cancer that has_material_basis_in epithelial cells."} -{"_id": 407, "text": "A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans."} -{"_id": 410, "text": "A dystonia that is localized to a specific part of the body."} -{"_id": 413, "text": "A bartonellosis that has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella quintana. The disease is characterized by the proliferation of blood vessels, resulting in them forming tumour-like masses in the skin and other organs."} -{"_id": 416, "text": "A disease of cellular proliferation that results in an abnormal mass of tissue."} -{"_id": 419, "text": "A germ cell cancer that has_material_basis_in cells that line the yolk sac of the embryo."} -{"_id": 422, "text": "A combined T cell and B cell immunodeficiency that is caused by a mutatino in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay."} -{"_id": 425, "text": "A viral infectious disease that results_in infection, has_material_basis_in RNA viruses, which have RNA as their genetic material."} -{"_id": 428, "text": "A Vibrio infectious disease that involves inflammation of the stomach and intestines caused by noncholera Vibrio species like Vibrio parahaemolyticus, Vibrio fluvialis and Vibrio vulnificus. Some species produce enterotoxins, which impair intestinal absorption, resulting in watery diarrhea. The symptoms include abdominal cramps, fever, vomiting, nausea and diarrhea."} -{"_id": 431, "text": "An embryonal carcinoma that is located_in the ovary."} -{"_id": 434, "text": "A breast carcinoma that derives_from breast lobules (milk glands)."} -{"_id": 437, "text": "An anal canal cancer that derives_from epithelial cells of glandular origin."} -{"_id": 440, "text": "An eye disease that is located_in the retina."} -{"_id": 443, "text": "A tinea capitis that results_in fungal infection located_in cuticle of hair, has_material_basis_in Microsporum canis, has_material_basis_in Microsporum gypseum, has_material_basis_in Trichophyton equinum, and has_material_basis_in Trichophyton verrucosum, which produce arthroconidia on the exterior of the hair shaft."} -{"_id": 446, "text": "A dsDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Polyomaviridae viruses."} -{"_id": 449, "text": "An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone."} -{"_id": 452, "text": "An Enterovirus infectious disease that results_in infection, has_material_basis_in group A coxsackievirus or has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom paralysis, has_symptom myositis, and has_symptom degeneration of neuronal tissue."} -{"_id": 455, "text": "A fibrosarcoma of soft tissue and small intestinal sarcoma that is located_in the small bowel."} -{"_id": 458, "text": "A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites."} -{"_id": 461, "text": "A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver."} -{"_id": 464, "text": "A lysosomal storage disease that has_material_basis_in deficiency of the beta-A-manosidase enzyme resulting in the disruption of N-linked glycoprotein oligosaccharide catabolism."} -{"_id": 467, "text": "An acrofacial dysostosis characterized by underdeveloped cheek bones, very small lower jaw, cleft palate, defects in the middle ear, absent eyelashes, and a notch in the lower eyelids called a coloboma, in children."} -{"_id": 470, "text": "A syndrome characterized by a combination of obesity, retarded development of the sex glands, and changes in secondary sex characteristics that results from impaired function or disease of the pituitary gland and hypothalamus."} -{"_id": 473, "text": "An opportunistic mycosis that results_in systemic fungal infection in immunocompromised people, has_material_basis_in Microsporidia phylum members."} -{"_id": 476, "text": "A vein disease that is characterized by inflammation of a vein."} -{"_id": 479, "text": "A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae."} -{"_id": 482, "text": "A viral infectious disease that results_in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted_by Phlebotomus papatasi sandfly. The infection has_symptom fever, has_symptom severe frontal headaches, has_symptom muscle ache, has_symptom joint aches, has_symptom flushing of the face, and has_symptom tachycardia."} -{"_id": 485, "text": "An acromesomelic dysplasia that has_material_basis_in mutation in CDMP-1 which results_in micromelia, absence of middle and proximal phalanges and some metacarpal and metatarsal bones."} -{"_id": 488, "text": "A gastrointestinal tuberculosis that results_in inflammation located_in peritoneum, which results in formation of tubercles. The infection has_symptom abdominal discomfort, has_symptom pain, has_symptom distention from gas or fluid, has_symptom digestive disturbances and has_symptom emaciation."} -{"_id": 491, "text": "A gonadal disease that is characterized by diminished functional activity of the gonads."} -{"_id": 494, "text": "A muscle tissue disease that is characterised by slow muscle relaxation associated with hyperexcitation of the muscle fibres."} -{"_id": 497, "text": "An orofaciodigital syndrome characterized_by polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of the OFD1 gene."} -{"_id": 500, "text": "An ampulla of Vater carcinoma that derives_from epithelial squamous cells."} -{"_id": 503, "text": "A rubella that results_in infection has_material_basis_in Rubella virus, which is transmitted_by congenital method to the developing fetus of a pregnant woman who has contracted rubella during her first trimester."} -{"_id": 506, "text": "A vulvovaginal candidiasis that involves fungal infection of the vaginal mucous membranes by Candida albicans in AIDS patients."} -{"_id": 509, "text": "A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck."} -{"_id": 512, "text": "A respiratory system cancer that is located_in the larynx."} -{"_id": 515, "text": "A hepatitis that involves viral infection causing inflammation of the liver."} -{"_id": 518, "text": "An extrinsic allergic alveolitis involving inflammation of the alveoli within the lung caused by hypersensitivity to the inhalation of organic dust particles derived from either the mushrooms, their spores or the compost in which the mushrooms are grown. It is usually caused by the spores of thermophilic actinomycetes."} -{"_id": 521, "text": "A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs."} -{"_id": 524, "text": "A cranial nerve disease that is located_in the optic nerve."} -{"_id": 527, "text": "A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior."} -{"_id": 530, "text": "A monogenic disease that has_material_basis_in muations in genes on the X chromosome."} -{"_id": 533, "text": "A pancreas cancer that derives_from epithelial cells located_in the pancreas."} -{"_id": 536, "text": "A spotted fever that has_material_basis_in Rickettsia akari, which is transmitted_by house mouse mite (Liponyssoides sanguineus) found on mice and other rodents. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, and has_symptom papulovesicular rash."} -{"_id": 539, "text": "A neuroendocrine tumor that results_in an overproduction of gastric acid."} -{"_id": 542, "text": "A craniosynostosis that involves premature fusion of certain skull bones. This early fusion prevents the skull from growing normally and affects the shape of the head and face. The disease is associated with mutations in the FGFR2 gene."} -{"_id": 545, "text": "A congenital disorder of glycosylation involve disrupted synthesis of the lipid-linked oligosaccharide precursor."} -{"_id": 548, "text": "A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium."} -{"_id": 551, "text": "An organ system cancer that is located_in the skin, hair and nails."} -{"_id": 554, "text": "A gastrointestinal system disease that is located_in the intestine."} -{"_id": 557, "text": "An actinomycosis that involves invasion and infiltration located_in large intestine, located_in greater omentum, or located_in abdominal wall, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus or has_material_basis_in Actinomyces meyeri, which produce a characteristic granulomatous inflammatory response, with pus production and has_symptom abscess formation."} -{"_id": 560, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of dogs, cats and foxes with Toxascaris leonina causing damage to the lining of the intestine. The symptoms include diarrhea, vomiting and loss of appetite."} -{"_id": 563, "text": "An eye disease characterized by missing pieces of tissue in structures that form the eye, such as the iris, retina, choroid or optic disc."} -{"_id": 566, "text": "A trichostrongyloidiasis that involves parasitic infection of the bronchial tree of horses, sheep, goats, deer, and cattle by nematodes of the genus Dictyocaulus."} -{"_id": 569, "text": "A dermatomycosis that results_in fungal infection located_in nail, has_material_basis_in Neoscytalidium dimidiatum and has_symptom rough nail, and has_symptom crumbly nail which can separate from the nail bed."} -{"_id": 572, "text": "A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located_in the upper dermis."} -{"_id": 575, "text": "A malignant glioma that is has_material_basis_in astocyte cells, a type of star-shaped glial cell, located_in the cerebrum."} -{"_id": 578, "text": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney."} -{"_id": 581, "text": "A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency."} -{"_id": 584, "text": "A large intestine cancer that has_material_basis_in epithelial cells of glandular origin."} -{"_id": 587, "text": "A syndrome characterized byvariable expression of microcephaly, ocular disorders including chorioretinopathy, congenital lymphedema of the lower limbs, and mild to moderate intellectual disability."} -{"_id": 590, "text": "A spinal cord glioma that has_material_basis_in cells linking the spinal cord central canal."} -{"_id": 593, "text": "A urinary system disease that is located_in the urethra."} -{"_id": 596, "text": "A skin disease characterized by a defect in the normal process of keratinization of the mucosa."} -{"_id": 599, "text": "A Charcot-Marie-Tooth disease that is characterized by early-onset optic atrophy resulting in progressive visual loss and peripheral axonal sensorimotor neuropathy with highly variable age at onset and severity."} -{"_id": 602, "text": "An autoimmune disease of the central nervous system."} -{"_id": 605, "text": "A cell type benign neoplasm that is a benign tumor of smooth muscle cells."} -{"_id": 608, "text": "A human papillomavirus related carcinoma that results_in infection, has_material_basis_in human papillomaviruses (types 16, 18, 31, 39 or 45), which cause lesions that progress to cancers."} -{"_id": 611, "text": "A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms."} -{"_id": 614, "text": "An anal carcinoma that arises near the squamocolumnar junction."} -{"_id": 617, "text": "Esotropia is a strabismus in which the eye turns inward toward the nose."} -{"_id": 620, "text": "A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. It has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma."} -{"_id": 623, "text": "A lymphatic system cancer that affects white blood cells and involves tumor deposits in the spleen."} -{"_id": 626, "text": "A female reproductive system disease characterized by the implantation of the embryo outside the uterine cavity."} -{"_id": 629, "text": "A pneumococcal infectious disease that involves infection by the bacterium Streptococcus pneumoniae, also known as pneumococcus. In adults, pneumococcal pneumonia is often characterized by sudden onset of illness with symptoms including shaking chills, fever, shortness of breath or rapid breathing, pain in the chest that is worsened by breathing deeply, and a productive cough. In infants and young children, signs and symptoms may not be specific, and may include fever, cough, rapid breathing or grunting."} -{"_id": 632, "text": "A syndrome that is a chronic unilateral (or rarely bilateral) iridocyclitis appearing with the triad of heterochromia, predisposition to cataracts and glaucoma, and keratitic percipitates on the posterior corneal surface."} -{"_id": 635, "text": "An ectothrix infectious disease that results_in geophilic fungal infection located_in scalp and located_in hair in humans and animals, has_material_basis_in Microsporum fulvum."} -{"_id": 638, "text": "A RNA virus infectious disease that results_in infection, has_material_basis_in ssRNA negative-strand viruses, which have negative-sense single-stranded RNA genomes."} -{"_id": 641, "text": "A malaria characaterized as a relatively mild form caused by a parasite Plasmodium ovale, which is characterized by tertian chills and febrile paroxysms, and that ends spontaneously."} -{"_id": 644, "text": "A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood."} -{"_id": 647, "text": "A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy."} -{"_id": 650, "text": "A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand."} -{"_id": 653, "text": "A malignant vascular tumor that results_in rapidly proliferating, extensively infiltrating anaplastic cells derived_from blood vessels and derived_from the lining of irregular blood-filled spaces."} -{"_id": 656, "text": "A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis."} -{"_id": 659, "text": "A lung carcinoma that is located_in large undifferentiated cells."} -{"_id": 662, "text": "A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung."} -{"_id": 665, "text": "An agnosia that is a deficiency in understanding, processing, or describing emotions."} -{"_id": 668, "text": "An osteochondrodysplasia that results_in thinning and the tendency to fracture located_in bone."} -{"_id": 671, "text": "An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway."} -{"_id": 674, "text": "An artery disease characterized by chronic elevated blood pressure in the arteries."} -{"_id": 677, "text": "A type of ALS with juvenile onset caused_by mutation located_in senataxin gene (SETX) located_in chromosome 9."} -{"_id": 680, "text": "An autosomal recessive disease that involves abnormal development of the pancreas, nose and scalp, with mental retardation, hearing loss and growth failure. It is inherited in an autosomal recessive manner."} -{"_id": 683, "text": "A smallpox that results_in milder infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions."} -{"_id": 686, "text": "A nonsyndromic deafness characterized by an autosomal dominant inheritance mode."} -{"_id": 689, "text": "A disease that is characterized by abnormally rapid cell division."} -{"_id": 692, "text": "A motor neuron disease characterized by painless but progressive weakness and stiffness of the muscles of the legs."} -{"_id": 695, "text": "A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis."} -{"_id": 698, "text": "An immune system disease that is located_in the lymphatic system."} -{"_id": 701, "text": "A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism."} -{"_id": 704, "text": "A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis."} -{"_id": 707, "text": "A vitamin metabolic disorder that has_material_basis_in mutations in the folate receptor 1 (FOLR1) gene coding for folate receptor alpha (FRalpha), is located_in the brain and is characterized by progressive movement disturbance, psychomotor decline, and epilepsy."} -{"_id": 710, "text": "A vascular disease that is characterized by a restriction in blood supply to tissues."} -{"_id": 713, "text": "A tertiary neurosyphilis that results_in mild meningitis."} -{"_id": 716, "text": "A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs."} -{"_id": 719, "text": "A viral infectious disease that results_in infection located_in joint, has_material_basis_in Ross River virus, which is transmitted_by Culex, and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash."} -{"_id": 722, "text": "An organic acidemia that involves an accumulation of methylmalonic acid in the blood."} -{"_id": 725, "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system."} -{"_id": 728, "text": "A parasitic protozoa infectious disease that occurs in the intestinal tract of animals and humans caused by Coccidia protozoa. Immunocompromised persons are at greater risk of developing the infection."} -{"_id": 731, "text": "A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy."} -{"_id": 734, "text": "An extragonadal germ cell cancer that are located_in the pineal gland in the brain, located_in the mediastinum or located_in the abdomen."} -{"_id": 737, "text": "A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_physical_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region."} -{"_id": 740, "text": "A Q fever that is a zoonotic infectious disease caused by Coxiella burnetii, a bacterium which affects both humans and animals. The symptoms include fever, headache, cough, pleuritic chest pain, myalgia and arthralgia. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, or excreta of infected herd animals, ingestion of contaminated milk, tick bites and human to human transmission."} -{"_id": 743, "text": "A rhabdomyosarcoma and sarcoma of the anus that is located_in the anus."} -{"_id": 746, "text": "A personality disorder that is characterized by a pervasive pattern of preoccupation with orderliness, perfectionism, and mental and interpersonal control at the expense of flexibility, openness, and efficiency."} -{"_id": 749, "text": "An achondrogenesis that has_material_basis_in mutations in the COL2A1 gene which results_in underdeveloped lungs, hydrops fetalis, a prominent forehead and abnormal ossification of the located_in vertebral column or located_in pelvis."} -{"_id": 752, "text": "A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange."} -{"_id": 755, "text": "A corneal disease characterized by a bilaterally enlarged corneal diameter without an increase in intraocular pressure; caused_by mutation in the CHRDL1 gene."} -{"_id": 758, "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in anus, has_material_basis_in human papillomavirus (types 16 or 18), which cause malignant tumors in squamous epithelium of anus."} -{"_id": 761, "text": "A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles."} -{"_id": 764, "text": "A liposarcoma and mediastinum sarcoma that is located_in the mediastinum."} -{"_id": 767, "text": "A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock."} -{"_id": 770, "text": "A Measles virus infectious disease that results_in inflammation located_in liver, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection causes hepatic dysfunction and has_symptom jaundice."} -{"_id": 773, "text": "A lactic acidosis that has_material_basis_in high levels of acid."} -{"_id": 776, "text": "A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance."} -{"_id": 779, "text": "An amino acid metabolic disorder that involves a deficiency of one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream."} -{"_id": 782, "text": "A nervous system cancer that is located_in the central nervous system."} -{"_id": 785, "text": "A delusional disorder in which a person holds a delusion that a friend, spouse, parent, or other close family member has been replaced by an identical-looking impostor."} -{"_id": 788, "text": "A urinary system disease that is located_in the bladder."} -{"_id": 791, "text": "A coccidioidomycosis that results_in inflammation located_in meninges, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom headache, has_symptom alterations in sensorium, and has_symptom obstructing hydrocephalus."} -{"_id": 794, "text": "A retinoblastoma that is located_in the eye and has not spread to other parts of the body."} -{"_id": 797, "text": "A somatoform disorder that involves persistently complaints of varied physical symptoms that have no identifiable physical origin."} -{"_id": 800, "text": "A gastrointestinal system disease that is located_in the liver and/or biliary tract."} -{"_id": 803, "text": "A tongue cancer that is located_in the squamous cells of the tongue."} -{"_id": 806, "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia."} -{"_id": 809, "text": "A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities."} -{"_id": 812, "text": "A tularemia that results_in swelling of regional lymph glands."} -{"_id": 815, "text": "An extrapulmonary tuberculosis that results in formation of lesions located_in bone."} -{"_id": 818, "text": "A familial hyperlipidemia characterized by very high levels of low-density lipoprotein (LDL) and early cardiovascular disease."} -{"_id": 821, "text": "A lung carcinoma that has_material_basis in a combination of squamous cells, mucus secreting cells and intermediate cells."} -{"_id": 824, "text": "A central nervous system disease characterized by acute neuritis located_in eye and demyelination located_in optic nerve and located_in spinal cord."} -{"_id": 827, "text": "An endothrix infectious disease that results_in anthropophilic fungal infection located_in scalp and located_in hair, has_material_basis_in Trichophyton soudanense."} -{"_id": 830, "text": "A pleural empyema which involves presence of pus in the pleural cavity and calcified visceral pleura. It results from a large number of mycobacteria spilling into the pleural space, usually from rupture of a cavity or an adjacent paranchymal focus via a bronchopleural fistula."} -{"_id": 833, "text": "An intrinsic cardiomyopathy characterized by distinctive (spongy) morphological appearance of the LV myocardium."} -{"_id": 836, "text": "A malignant mediastinal neurogenic neoplasm that has_material_basis_in immature nerve cells."} -{"_id": 839, "text": "A lysosomal storage disease characterized by increased sialic acid in the urine."} -{"_id": 842, "text": "A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person."} -{"_id": 845, "text": "A retinoblastoma that develops in both eyes."} -{"_id": 848, "text": "A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans."} -{"_id": 851, "text": "A HIV encephalopathy that results_in infection in adults located_in brain, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom cognitive impairment, has_symptom motor dysfunction, has_symptom behavioral change, and has_symptom speech problems."} -{"_id": 854, "text": "A viral infectious disease that results_in infection located_in brain in sheep and goats, has_material_basis_in Visna/Maedi virus , which is transmitted_by droplet spread of oronasal secretion, and transmitted_by ingestion of contaminated water, milk or colostrum. The infection has_symptom hindlimb weakness, has_symptom head tilt, has_symptom ataxia, has_symptom incoordination, has_symptom muscle tremors, has_symptom paresis, and has_symptom paraplegia."} -{"_id": 857, "text": "A leukemia that is characterized by the presence of abnormal white blood cells located_in peripheral blood, but in which the total number of white blood cells is normal."} -{"_id": 860, "text": "A plague that results_in infection located_in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has_symptom enlarged, tender lymph nodes, has_symptom fever, has_symptom chills and has_symptom prostration."} -{"_id": 863, "text": "A primary systemic mycosis that results_in systemic fungal infection through hematogenous spread, has_material_basis_in Paracoccidioides brasiliensis."} -{"_id": 866, "text": "A disease of anatomical entity that is located_in the thoracic cavity."} -{"_id": 869, "text": "A genetic disease that require multiple abnormal alleles to manifest are complex. These diseases are termed multifactorial or polygenic. Expressivity or penetrance of the disease is complex and is associated with multiple genes in combination with lifestyle and environmental factors. Multifactoral genetic diseases include heart disease and diabetes, although a subset of diabetes may be classified as a monogenic disease (due to the presence of a single abnormal allele)."} -{"_id": 872, "text": "A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells."} -{"_id": 875, "text": "A myeloma and spenic disease that is located_in the bone marrow that results_in the marrow being replaced by fibrous (scar) tissue and has_symptom abdominal fullness related to an enlarged spleen, has_symptom bone pain, has_symptom bruising, has_symptom easy bleeding, has_symptom fatigue, has_symptom increased susceptibility to infection, has_symptom pallor, has_symtom shortness of breath while doing physical work."} -{"_id": 878, "text": "A focal dystonia that is characterized by simultaneous contraction of the agonist and antagonist muscles that control the position of the head contracting during dystonic movement which causes the neck to involuntarily turn to the left, right, upwards, and/or downwards."} -{"_id": 881, "text": "An autosomal dominant disease that is characterized by imperforate anus, dysplastic ears often associated with sensorineural and/or conductive hearing impairment, and thumb malformations."} -{"_id": 884, "text": "An osteochondrodysplasia that has_material_basis_in mutations in the COMP gene which results_in short limb dwarfism."} -{"_id": 887, "text": "An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism."} -{"_id": 890, "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme alpha-L-iduronidase."} -{"_id": 893, "text": "A primary systemic mycosis that results_in inflammation located_in lungs, has_material_basis_in Paracoccidioides brasiliensis and has_symptom cough, has_symptom fever, has_symptom night sweats, has_symptom malaise, and has_symptom weight loss."} -{"_id": 896, "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue."} -{"_id": 899, "text": "An opportunistic mycosis that involves localized or hematogenously disseminated fungal infection by Fusarium solani or Fusarium oxysporum. Skin lesions are seen in neutropenic patients, and indolent cellulitis or soft-tissue necrosis occur in immunocompromised patients at the site of trauma."} -{"_id": 902, "text": "An adenovirus infectious disease described as the infection of the lungs by adenoviruses (1,2, 3 and 7) especially in infants and children. In mild form of infection, findings of interstitial inflammatory cell infiltration may predominate, and nuclear inclusion bodies, most prominent in alveolar lining cells, may be identified in infected cells."} -{"_id": 905, "text": "A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy."} -{"_id": 908, "text": "An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities."} -{"_id": 911, "text": "A peroxisomal disease that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes."} -{"_id": 914, "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash."} -{"_id": 917, "text": "A primary bacterial infectious disease that results_in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli."} -{"_id": 920, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection by flukes of the genus Paragonimus. In the acute phase, the symptoms are diarrhea, abdominal pain, fever, cough, urticaria, hepatosplenomegaly, pulmonary abnormalities, and eosinophilia. Pulmonary manifestations include cough, expectoration of discolored sputum, hemoptysis, and chest radiographic abnormalities. Various organs like brain, spleen and liver can be infected."} -{"_id": 923, "text": "A reproductive system disease that affects male reproductive organs."} -{"_id": 926, "text": "A primary bacterial infectious disease that results_in infection located_in skin, located_in joint or located_in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has_symptom skin lesions."} -{"_id": 929, "text": "A ssRNA-RT virus infectious disease that results_in infection in animals and humans, has_material_basis_in Retroviridae viruses."} -{"_id": 932, "text": "An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough."} -{"_id": 935, "text": "A hypertension with no known cause. It is the most common type of hypertension."} -{"_id": 938, "text": "An X-linked disease that is characterized by profound congenital sensorineural hearing impairment, early-onset hypotonia, delayed motor development, mild to moderate intellectual disability, ataxia, and increased risk of infection and has_material_basis_in mutations of the PRPS1 gene."} -{"_id": 941, "text": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma."} -{"_id": 944, "text": "A lipid metabolism disorder characterized by elevated triglyceride levels as a result of excess hepatic production of VLDL or heterozygous LPL deficiency."} -{"_id": 947, "text": "An autosomal recessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy."} -{"_id": 950, "text": "A Kaposi's sarcoma and AIDS-related malignancy that results_in the occurence of Kaposi's sarcoma in people that have progressed to AIDS."} -{"_id": 953, "text": "A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree."} -{"_id": 956, "text": "A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy."} -{"_id": 959, "text": "An eye disease characterized by the drooping or falling of the upper or lower eyelid."} -{"_id": 962, "text": "An agnosia that is a loss of the ability to integrate these elements together into comprehensible perceptual wholes while recognizing elements of the whole."} -{"_id": 965, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding."} -{"_id": 968, "text": "A pancreatic cancer that is located_in the pancreas and that arises from transformed cells of mesenchymal origin."} -{"_id": 971, "text": "A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches."} -{"_id": 974, "text": "A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough."} -{"_id": 977, "text": "A carcinoma in situ that is characterized by the spread of cancer in the digestive organ and the lack of invasion of surrounding tissues."} -{"_id": 980, "text": "A breast disease characterized by a collection of pus in the breast."} -{"_id": 983, "text": "An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures."} -{"_id": 986, "text": "An inflammatory bowel disease that involves inflammation located_in colon."} -{"_id": 989, "text": "A sarcoma that affects children and is located_in the soft tissues of the body."} -{"_id": 992, "text": "A prostate carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 995, "text": "An endocrine gland located_in the pineal gland located in the brain."} -{"_id": 998, "text": "A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells."} -{"_id": 1001, "text": "A neuromuscular junction disease that results from an abnormality of acetylcholine (ACh) release at the neuromuscular junction. It results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal."} -{"_id": 1004, "text": "A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food."} -{"_id": 1007, "text": "A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze."} -{"_id": 1010, "text": "A parasitic stramenopiles infectious disease that involves infection of the intestine with a pathogenic heterokont Blastocystis hominis. The symptoms include watery diarrhea, abdominal pain, perianal pruritus, and excessive flatulence."} -{"_id": 1013, "text": "A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight."} -{"_id": 1016, "text": "A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs."} -{"_id": 1019, "text": "A nonparalytic poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 3, which is transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms."} -{"_id": 1022, "text": "A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers."} -{"_id": 1025, "text": "A bone structure disease that results_in change or damage of structure located_in bone."} -{"_id": 1028, "text": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions."} -{"_id": 1031, "text": "A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb."} -{"_id": 1034, "text": "A myopathy characterized by muscle inflammation."} -{"_id": 1037, "text": "A type of ALS caused_by mutation located_in CHMP2B gene located_in chromosome 3."} -{"_id": 1040, "text": "A hematologic cancer that has_material_basis_in lymphoma located_in central nervous system."} -{"_id": 1043, "text": "A bone development disease that results_in defective development of cartilage or bone."} -{"_id": 1046, "text": "A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency."} -{"_id": 1049, "text": "A bone remodeling disease that results in an abnormal decrease of bone density or mass."} -{"_id": 1052, "text": "A mycoplasmal pneumonia that is a contagious infection of pigs caused my Mycoplasma hyopneumoniae resulting in lung lesions and chronic cough."} -{"_id": 1055, "text": "An organ system benign neoplasm located_in gastrointestinal tract organs."} -{"_id": 1058, "text": "A type of ALS caused_by mutation located_in FIG4 gene located_in chromosome 6."} -{"_id": 1061, "text": "A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body."} -{"_id": 1064, "text": "An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derived_from multiple cell types including astrocytes and oligondroctyes."} -{"_id": 1067, "text": "A specific developmental disorder that involves specific developmental disorders of speech and language."} -{"_id": 1070, "text": "A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts."} -{"_id": 1073, "text": "An ovary epithelial cancer that has_material_basis_in the endometrium and is located_in the ovary."} -{"_id": 1076, "text": "A hypersensitivity reaction type I disease triggered by a metal."} -{"_id": 1079, "text": "An intestinal benign neoplasm that is located_in the cecum."} -{"_id": 1082, "text": "A bartonellosis that results_in infection located_in endothelial cells or located_in red blood cells, has_material_basis_in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed."} -{"_id": 1085, "text": "A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body."} -{"_id": 1088, "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Flaviviridae viruses, which are transmitted_by arthropod vectors."} -{"_id": 1091, "text": "An autosomal recessive disease characterized by photosensitivity and liver spots (solar lentigines)."} -{"_id": 1094, "text": "An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life."} -{"_id": 1097, "text": "An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system."} -{"_id": 1100, "text": "A pneumococcal infectious disease that involves inflammation of the peritoneum caused by streptococcal infection. The symptoms include diarrhea, fever, fasciitis and influenza-like syndrome."} -{"_id": 1103, "text": "A reading disorder resulting from a developmental reading disability involving the inability to process graphic symbols resulting in impairment of reading ability."} -{"_id": 1106, "text": "A labyrinthitis which involves viral infection of the inner ear through the upper airway or the blood stream. The symptoms may include hearing loss and ringing in the ears. If the virus reaches the vestibular system, dizziness, severe vertigo with nausea and vomiting, and imbalance can occur."} -{"_id": 1109, "text": "A type of ALS caused_by mutation located_in PFN1 gene located_in chromosome 17."} -{"_id": 1112, "text": "A physical disorder that has_material_basis_in abnormal segmentation of the vertebra during fetal development which results_in fusion located_in cervical vertebra."} -{"_id": 1115, "text": "An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue."} -{"_id": 1118, "text": "A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly."} -{"_id": 1121, "text": "An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes."} -{"_id": 1124, "text": "A hypersensitivity reaction type I disease triggered by a drug."} -{"_id": 1127, "text": "A germ cell cancer that is associated with an embryo."} -{"_id": 1130, "text": "A monogenic disease that results from a reduced functionality of DNA repair."} -{"_id": 1133, "text": "A bone cancer and malignant neoplasm of chest wall that is located_in the chest wall."} -{"_id": 1136, "text": "A Kaposi's sarcoma that is located_in black Africans."} -{"_id": 1139, "text": "A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous."} -{"_id": 1142, "text": "An organ system benign neoplam that is located_in the thoracic cavity."} -{"_id": 1145, "text": "A cholestasis characterized by blockage of the ducts that carry bile from the liver to the gallbladder."} -{"_id": 1148, "text": "A histiocytic and dendritic cell cancer that is mainly located_in lymph nodes."} -{"_id": 1151, "text": "A mitochondrial metabolism disease that has material basis in mutation in the ATP5A1 gene on chromosome 18q."} -{"_id": 1154, "text": "A pyoderma that is a milder form of diphtheria restricted to the skin producing shallow skin ulcers is caused by direct physical contact of indivduals infected with Corynebacterium diphtheriae as the bacteria releases the diphtheria toxin."} -{"_id": 1157, "text": "An African histoplasmosis that results_in inflammation located_in lung, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom mediastinal lymphadenopathy, has_symptom cough and has_symptom chest pain."} -{"_id": 1160, "text": "A brucellosis that involves an infection caused by Brucella suis in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue."} -{"_id": 1163, "text": "A retinoblastoma that effects only one eye."} -{"_id": 1166, "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Cytomegalovirus, which is transmitted_by contact with the infected person's bodily fluids or transmitted_by sexual contact, or transmitted_by blood transfusions."} -{"_id": 1169, "text": "An inherited blood coagulation disease that has_material_basis_in Factor IX deficiency, which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait."} -{"_id": 1172, "text": "A monogenic disease that is caused by a mutation in a single gene on one of the non-sex chromosomes."} -{"_id": 1175, "text": "A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation."} -{"_id": 1178, "text": "A frontal sinusitis which lasts for less than 4 weeks."} -{"_id": 1181, "text": "A crustacean allergy triggered by Farfantepenaeus aztecus."} -{"_id": 1184, "text": "A Simplexvirus infectious disease that results_in inflammation located_in external ear, has_material_basis_in Human herpesvirus 1 or has-agent Human herpesvirus 2 and has_symptom vesicles in the ear canal."} -{"_id": 1187, "text": "An endothrix infectious disease that results_in anthropophilic fungal infection located_in scalp and located_in hair, has_material_basis_in Trichophyton yaoundei, results_in_formation_of lesions."} -{"_id": 1190, "text": "A carcinosarcoma that has_material_basis_in gland and muscle components."} -{"_id": 1193, "text": "A bacterial pneumonia caused by the genus Mycoplasma."} -{"_id": 1196, "text": "A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has_symptom gummatous ulcers, has_symptom periosteal lesions, has_symptom paresis, has_symptom tabes, has_symptom optic atrophy, has_symptom interstitial keratitis, has_symptom sensorineural deafness, and has_symptom dental deformities."} -{"_id": 1199, "text": "A neuropathy that is located_in one of the twelve cranial nerves."} -{"_id": 1202, "text": "A genital herpes that results_in infection located_in vulva and located_in vagina, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2 and has_symptom fever, has_symptom lymphadenopathy, and has_symptom lesions."} -{"_id": 1205, "text": "A leiomyosarcoma and sarcoma of bile duct that is located_in the bile duct or located_in the outside of the liver."} -{"_id": 1208, "text": "A bilirubin metabolic disorder that involves a build up of bilirubin as bilirubin is not being broken down as a result of a lack or deficiency of the enzyme uridine diphosphate glycosyltransferase (UGT)."} -{"_id": 1211, "text": "An arthritis that involves infection by a pathogen located_in joint."} -{"_id": 1214, "text": "A lymphatic system cancer that is located_in the lymph node."} -{"_id": 1217, "text": "A glomerulonephritis characterized by build up of IgA antibody in the glomerulus."} -{"_id": 1220, "text": "A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc."} -{"_id": 1223, "text": "A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis."} -{"_id": 1226, "text": "A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules."} -{"_id": 1229, "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria."} -{"_id": 1232, "text": "A kyphosis that has_material_basis_in slouching which results_in stretching of spinal ligament and abnormal formation located_in vertebra."} -{"_id": 1235, "text": "A central nervous system sarcoma that is located_in the inner lining of blood vessels."} -{"_id": 1238, "text": "A combined T cell and B cell immunodeficiency that is an autosomal recessive immunodeficiency associated with mutations in the recombination activating genes (RAG1 and RAG2), affecting circulating levels of both B-cells and T-cells."} -{"_id": 1241, "text": "A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash."} -{"_id": 1244, "text": "A peritonitis which involves inflammation of peritoneal cavity by Corynebacterium diphtheriae."} -{"_id": 1247, "text": "A pelvic varix disease characterized by swollen, inflamed veins around the anus or lower rectum."} -{"_id": 1250, "text": "A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure."} -{"_id": 1253, "text": "A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death."} -{"_id": 1256, "text": "An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body."} -{"_id": 1259, "text": "An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain."} -{"_id": 1262, "text": "A supratentorial cancer that is located_in the cerebrum."} -{"_id": 1265, "text": "A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system."} -{"_id": 1268, "text": "A chronic lymphocytic leukemia that is characterized by the presence of immature lymphocytes in the blood and bone marrow and/or in the lymph nodes."} -{"_id": 1271, "text": "A mature B-cell neoplasm of B-cells found in the germinal center."} -{"_id": 1274, "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic mesoderm."} -{"_id": 1277, "text": "A parasitic ectoparasitic infectious disease that is caused by parasitic dipterous fly larvae (maggots) feeding on the host's necrotic or living tissue."} -{"_id": 1280, "text": "A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs."} -{"_id": 1283, "text": "A cranio-facial dystonia that is accompanied by blepharospasm."} -{"_id": 1286, "text": "A syndrome characterized by hydrocephalus, spasticity of the lower limbs, adducted thumbs, aphasia, seizures, agenesis of the corpus callosum and intellectual disability in the mild to moderate range."} -{"_id": 1289, "text": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes."} -{"_id": 1292, "text": "An opportunistic mycosis that results_in fungal infection located_in human body, has_material_basis_in Basidiomycota phylum members."} -{"_id": 1295, "text": "A primary systemic mycosis that results_in systemic fungal infection in animals and humans, has_material_basis_in Stachybotrys chartarum, transmitted_by airborne spores and transmitted_by vehicle-borne ingestion and the fungus produces trichothecene mycotoxins including satratoxins causing pulmonary hemorrhage in infants."} -{"_id": 1298, "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters."} -{"_id": 1301, "text": "An adrenal medulla cancer that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin."} -{"_id": 1304, "text": "An anus disease characterized by is an abnormal connection between the epithelialised surface of the anal canal and the perianal skin."} -{"_id": 1307, "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from germ cells."} -{"_id": 1310, "text": "A neurodegenerative disease that is located_in the motor neurones."} -{"_id": 1313, "text": "An angiosarcoma that is located_in the aorta."} -{"_id": 1316, "text": "A carcinoma that is derived_from epithelial cells with finger like projections."} -{"_id": 1319, "text": "A salivary gland cancer that is located_in the sublingual gland."} -{"_id": 1322, "text": "A salivary gland cancer that is located_in the parotid gland."} -{"_id": 1325, "text": "A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord."} -{"_id": 1328, "text": "An autoimmune disease of centreal nervous system caused by an autoimmune response."} -{"_id": 1331, "text": "An autosomal dominant disease that is characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form caused by mutations in a transcript variant of CACNA1C."} -{"_id": 1334, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever."} -{"_id": 1337, "text": "A syndrome that is characterized by advanced bone age, failure to thrive, respiratory problems, dysmorphic facial features, and variable mental retardation."} -{"_id": 1340, "text": "An endocarditis that results from the deposition of small sterile vegetations on valve leaflets."} -{"_id": 1343, "text": "A neonatoal period electroclinical syndrome that is characterized by tonic spasms and partial seizures."} -{"_id": 1346, "text": "An inherited metabolic disorder that involves the creation and degradation of lipids."} -{"_id": 1349, "text": "A parasitic helminthiasis infectious disease that involves infection of the bowel by Hymenolepis nana or Hymenolepis diminuta. The symptoms include diarrhea, gastrointestinal discomfort, itchy anus, poor appetite and weakness."} -{"_id": 1352, "text": "An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell."} -{"_id": 1355, "text": "An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra."} -{"_id": 1358, "text": "A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body."} -{"_id": 1361, "text": "An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place."} -{"_id": 1364, "text": "A Coronaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in coronaviruses, which are transmitted_by droplet spread of respiratory secretions or transmitted_by ingestion of contaminated food."} -{"_id": 1367, "text": "A pancreas adenocarcinoma that has_material_basis_in cells with morphological resemblance to acinar cells and is associated with increased serum lipase."} -{"_id": 1370, "text": "An autosomal recessive disease characterized by abnormal pigmentation of the skin, hair and eyes."} -{"_id": 1373, "text": "A neurodegenerative disease that is characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements."} -{"_id": 1376, "text": "A mitochondrial metabolism disease that has material basis in mutation in the ATP5E gene on chromosome 20q13."} -{"_id": 1379, "text": "A prion disease characterized by adult onset of memory loss, dementia, ataxia, and pathologic deposition of amyloid-like plaques in the brain."} -{"_id": 1382, "text": "A syndrome that involves arachnodactyly, receding lower jaw, and joint laxity limited to the hands and feet."} -{"_id": 1385, "text": "A trichomoniasis that involves infection of the urogenital tract, has_material_basis_in Trichomonas vaginalis, which is transmitted through sexual contact. Symptoms include inflammation of the cervix, urethra and vagina which produce an itching or burning sensation, and yellow-green, itchy, frothy foul-smelling vaginal discharge."} -{"_id": 1388, "text": "A personality disorder that is characterized by paranoia and a pervasive, long-standing suspiciousness and generalized mistrust of others."} -{"_id": 1391, "text": "A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host."} -{"_id": 1394, "text": "A hemiplegia characterized by recurrent episodes of temporary weakness or complete paralysis on one or both sides of the body."} -{"_id": 1397, "text": "A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region."} -{"_id": 1400, "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk."} -{"_id": 1403, "text": "A congenital disorder of glycosylation that involves malfunctioning trimming/processing of the protein-bound oligosaccharide chain."} -{"_id": 1406, "text": "A connective tissue cancer that located_in the pleura."} -{"_id": 1409, "text": "An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus."} -{"_id": 1412, "text": "A vein disease that is characterized by a blood clot that forms within the hepatic portal vein."} -{"_id": 1415, "text": "A prostate carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 1418, "text": "A follicular thyroid carcinoma that has_material_basis_in parafollicular cells."} -{"_id": 1421, "text": "A thalassemia characterized by the reduced or absent synthesis of the beta globin chains of hemoglobin."} -{"_id": 1424, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations."} -{"_id": 1427, "text": "A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM)."} -{"_id": 1430, "text": "A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching."} -{"_id": 1433, "text": "A gamma-amino butyric acid metabolism disorder that is characterized by an excess of homocarnosine in the brain and has_material_basis_in a deficiency of serum carnosinase in its ability to hydrolyze homocarnosine."} -{"_id": 1436, "text": "An anxiety disorder which results from a traumatic experience that results in psychological trauma."} -{"_id": 1439, "text": "An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system."} -{"_id": 1442, "text": "A gallbladder carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 1445, "text": "A rete testis neoplasm that derives_from epithelial cells of glandular origin."} -{"_id": 1448, "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Saffold virus, which is transmitted_by ingestion of food contaminated with feces. The infection has_symptom watery diarrhea, has_symptom fever, has_symptom nausea, and has_symptom vomiting."} -{"_id": 1451, "text": "A syndrome characterized by blepharophimosis, blepharoptosis, highly arched eyebrows hypertelorism, cleft lip and palate, postnatal growth deficiency, cognitive impairment, hearing loss and, in a smaller percentage of cases, craniosynostosis, radioulnar synostosis and genital and vesicorenal anomalies. It encompasses four disorders that were previously designated the Malpuech, Michels, Mingarelli and Carnevale syndromes."} -{"_id": 1454, "text": "An adenoma that is a cystic."} -{"_id": 1457, "text": "A pre-eclampsia that has_symptom at least one of the following: SBP of 160mm HG or higher or DPB of 110mm HG or higher on 2 occasions at least 6 hours apart, proteinuria more than 5g in a 24-hour collection, pulmonary edema or cyanosis, oliguria, persistent headaches, epigastric pain and/or impaired liver function, thrombocytopenia, oligohydramnios, decreased fetal growth or placental abruption."} -{"_id": 1460, "text": "A mitochondrial metabolism disease that has material basis in mutation in the TMEM70 gene on chromosome 8q21."} -{"_id": 1463, "text": "A pituitary gland disease characterized by the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland."} -{"_id": 1466, "text": "An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system."} -{"_id": 1469, "text": "A myeloma and anemia that is located_in some people with diseases that affect the bone marrow."} -{"_id": 1472, "text": "A kidney cancer that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products)."} -{"_id": 1475, "text": "A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting."} -{"_id": 1478, "text": "A Simplexvirus infectious disease that results in inflammatory response by the immune system of the body to Human herpesvirus 1 or Human herpesvirus 2 in the blood, urine, lungs, skin, or other tissues. The symptoms include fever, chills, rapid breathing, and rapid heart rate."} -{"_id": 1481, "text": "An adrenal adenoma that is a benign tumor of the adrenal cortex."} -{"_id": 1484, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea."} -{"_id": 1487, "text": "A Arteriviridae infectious disease that results_in infection in animals, has_material_basis_in Arterivirus."} -{"_id": 1490, "text": "A leukocyte disorder that is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection."} -{"_id": 1493, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Metagonimus yokogawai. The symptoms are diarrhea and colicky abdominal pain. The heart and brain can also be infected."} -{"_id": 1496, "text": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills."} -{"_id": 1499, "text": "A dysgerminoma that is located_in the ovary."} -{"_id": 1502, "text": "A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality."} -{"_id": 1505, "text": "A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus."} -{"_id": 1508, "text": "A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling."} -{"_id": 1511, "text": "A heavy chain disease that results from an overproduction of delta antibody (IgD)."} -{"_id": 1514, "text": "An endocrine system disease that is located_in the gonads."} -{"_id": 1517, "text": "An autosomal recessive disease that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life."} -{"_id": 1520, "text": "A dermatomycosis that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Lacazia loboi and has_symptom crusty plaques, has_symptom tumors and results_in_formation_of nodular lesions."} -{"_id": 1523, "text": "An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system."} -{"_id": 1526, "text": "A cutaneous mycosis that results_in fungal infection located_in skin or of its appendages, has_material_basis_in Ascomycota fungi other than the dermatophytes."} -{"_id": 1529, "text": "An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness."} -{"_id": 1532, "text": "A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly."} -{"_id": 1535, "text": "A carcinoma that results_in a lesion that breaks through the boundary located_in the duct or located_in the lobule."} -{"_id": 1538, "text": "A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate."} -{"_id": 1541, "text": "An impaired renal function disease characterized by a complete or partial resistance of the kidneys to vasopressin (ADH)."} -{"_id": 1544, "text": "An amino acid metabolic disorder that has_material_basis_in defects in the biosynthesis of the amino acid L-serine."} -{"_id": 1547, "text": "An eye and adnexa disease that is located_in the adnexa of the eye."} -{"_id": 1550, "text": "A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles."} -{"_id": 1553, "text": "A pneumoconiosis that involves allergic response located_in lungs caused by inhalation of beryllium compounds."} -{"_id": 1556, "text": "A hypersensitivity reaction type II disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; caused by mutations in the MEFV gene, which encodes the protein pyrin."} -{"_id": 1559, "text": "An inherited metabolic disorder involving dysfunction of pyrimidine metabolism."} -{"_id": 1562, "text": "A viral infectious disease that results_in infection located_in liver, has_material_basis_in Torque teno virus, which is transmitted_by blood transfusion."} -{"_id": 1565, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis."} -{"_id": 1568, "text": "A small intestine carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 1571, "text": "A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities."} -{"_id": 1574, "text": "An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus Penicillium glabrum. The symptoms include dyspnea, wheezing cough, fever and asthenia."} -{"_id": 1577, "text": "A (-)ssRNA virus infectious disease that results_in infection in humans, has_material_basis_in Mononegavirales viruses."} -{"_id": 1580, "text": "A focal dystonia that is characterized as dystonia that affects the muscles of the head, face, and neck."} -{"_id": 1583, "text": "A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly."} -{"_id": 1586, "text": "A inner ear infectious disease which involves inflammation of the labyrinths."} -{"_id": 1589, "text": "An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes."} -{"_id": 1592, "text": "A pancreatic carcinoma that is characterized by its papillary architecture."} -{"_id": 1595, "text": "A plague that results_in infection located_in lung, which results from direct inhalation of the bacillus and has_symptom fever, has_symptom chills, has_symptom cough and has_symptom difficulty breathing."} -{"_id": 1598, "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme resulting in incomplete breakdown of the heparan sulfate sugar chain."} -{"_id": 1601, "text": "A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per \u00b5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS."} -{"_id": 1604, "text": "A mycoplasmal pneumonia that is caused by the bacterial species Mycoplasma pneumoniae. The symptoms include chest pain, chills, dry cough which is not bloody, excessive sweating, fever, headache and sore throat."} -{"_id": 1607, "text": "An amebiasis that involves infection of the skin caused by the parasite Entamoeba histolytica, resulting in lesions on the body."} -{"_id": 1610, "text": "A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 1613, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Colorado tick fever virus which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom stiff neck, has_symptom chills, has_symptom hallucinations, has_symptom disorientation, and has_symptom memory loss."} -{"_id": 1616, "text": "A commensal bacterial infectious disease that is caused by Chlamydia trachomatis."} -{"_id": 1619, "text": "A focal dystonia that is characterized by the involuntary, forcible contraction of the muscles controlling eye blinks."} -{"_id": 1622, "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Varicellovirus."} -{"_id": 1625, "text": "A glucose metabolism disorder that is characterized by chronic haemolytic anaemia, cardiomyopathy, susceptibility to infections and severe neurological dysfunction, and has_physical_basis_in the triosephosphate isomerase enzyme (TPI1) gene inherited as an autosomal recessive trait."} -{"_id": 1628, "text": "A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages."} -{"_id": 1631, "text": "A viral infectious disease that results_in infection, located_in lungs or located_in kidney, has_material_basis_in Hantavirus, which is transmitted_by rodents. The infection has_symptom renal failure, has_symptom hemorrhagic manifestations, and has_symptom pulmonary edema."} -{"_id": 1634, "text": "A coccidiosis that involves infection of the epithelial cells of the small intestine with Cystoisospora belli, which results in nonbloody diarrhea with crampy abdominal pain, malabsorption and weight loss."} -{"_id": 1637, "text": "An aspergillosis that involves fungal infection of the tonsils by Aspergillus species."} -{"_id": 1640, "text": "A spastic cerebral palsy that affects only one limb."} -{"_id": 1643, "text": "A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment."} -{"_id": 1646, "text": "A cerebral palsy that is caused by injury to both the pyramidal and extra pyramidal areas of the brain, which results in both the tight muscle tone and the involuntary movements. The individual have difficulty with speaking and swallowing."} -{"_id": 1649, "text": "A pulmonary tuberculosis in which dissemination of the infection by Mycobacterium tuberculosis has occured to parts of the same lung or the opposite lung through rupture of a caseous lymph node into a bronchus."} -{"_id": 1652, "text": "A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa."} -{"_id": 1655, "text": "A lymphatic system disease that is characterized by an excessive number of histiocytes."} -{"_id": 1658, "text": "A primary bacterial infectious disease that results_in infection located_in skin or located_in mucosa of genital tract, has_material_basis_in Klebsiella granulomatis, transmitted by sexual contact or transmitted_by contact with the open sores. The infection has_symptom painless genital ulcers."} -{"_id": 1661, "text": "An inflammatory bowel disease characterized by inflammation located_in colon and located_in ileum, has_symptom diarrhea, has_symptom weight loss, has_symptom abdominal pain in middle or lower right part."} -{"_id": 1664, "text": "A sarcoma and malignant tumor of extrahepatic bile duct that is located_in the bile duct."} -{"_id": 1667, "text": "A viral infectious disease that results_in infection in ruminants, has_material_basis_in Bluetongue virus, which is transmitted_by Culicoides imicola midge. The infection has_symptom fever, has_symptom excessive salivation, has_symptom swelling of the face and tongue, and has_symptom cyanosis of the tongue."} -{"_id": 1670, "text": "A dsDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Papillomaviridae viruses."} -{"_id": 1673, "text": "An autosomal dominant disease that is characterized by heart arrhythmia defined as a short QT interval on an EKG (less than 300 ms) that does not significantly change with heart rate, tall and peaked T waves, and a structurally normal heart."} -{"_id": 1676, "text": "A beta-lactam allergy triggered by penicillin."} -{"_id": 1679, "text": "An autosomal dominant disease that is characterized by large-joint dislocations and characteristic craniofacial abnormalities."} -{"_id": 1682, "text": "A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information."} -{"_id": 1685, "text": "An intracranial aneurysm with a characteristic rounded shape; the most common form of cerebral aneurysm."} -{"_id": 1688, "text": "A childhood electroclinical syndrome characterized by the occurrence of typical absence seizures starting between the age of four and ten years."} -{"_id": 1691, "text": "A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue."} -{"_id": 1694, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts."} -{"_id": 1697, "text": "An agnosia that is the loss of the ability to recognize objects by touch based on its texture, size and weight."} -{"_id": 1700, "text": "A renal tubular transport disease that is characterized by tubular proteinuria, hypercalciuria, calcium nephrolithiasis, nephrocalcinosis and chronic kidney failure and has_material_basis_in X-linked recessive inheritance of mutations in the CLCN5 gene or OCRL1 gene."} -{"_id": 1703, "text": "A bone disease that results_in formation or resorption abnormalities located_in bone."} -{"_id": 1706, "text": "A lymphoma that begins in cells of the immune system in which different types of lymphoma cells occur at the same time."} -{"_id": 1709, "text": "An anal carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin."} -{"_id": 1712, "text": "A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck."} -{"_id": 1715, "text": "A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache."} -{"_id": 1718, "text": "A muscular dystrophy that is characterized by weakening of the muscles of the hip and shoulders which comprise the limb girdle muscles."} -{"_id": 1721, "text": "A type of ALS caused_by mutation located_in C9ORF72 gene located_in chromosome 9. It is characterized by adult onset of either frontotemporal dementia and/or amyotrophic lateral sclerosis."} -{"_id": 1724, "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Enterovirus, which is transmitted_by direct contact with secretions from an infected person, transmitted_by fomites, transmitted_by droplet spread of oronasal secretions from an infected person, or transmitted_by ingestion of contaminated food."} -{"_id": 1727, "text": "A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as."} -{"_id": 1730, "text": "An ureter carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 1733, "text": "An urogenital tuberculosis that is located_in ureter resulting in ureteral strictures."} -{"_id": 1736, "text": "A candidiasis that results_in fungal infection of the outer-most layer located_in nail, has_material_basis_in Candida species. The infection causes painful, red, swollen area around the nail, often at the cuticle or at the site of a hangnail or other injury."} -{"_id": 1739, "text": "A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis."} -{"_id": 1742, "text": "A nonsyndromic deafness characterized by an X-linked inheritance mode."} -{"_id": 1745, "text": "A gastrointestinal system cancer that is located_in the intestine."} -{"_id": 1748, "text": "An amebiasis that involves infection of the brain caused by the parasite Entamoeba histolytica resulting in brain abscesses."} -{"_id": 1751, "text": "An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal."} -{"_id": 1754, "text": "A skin disease characterized by congenital blistering, skin atrophy, photosensitivity, skin fragility, and scaling."} -{"_id": 1757, "text": "An extraocular retinoblastoma that effects children."} -{"_id": 1760, "text": "A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism."} -{"_id": 1763, "text": "A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo."} -{"_id": 1766, "text": "A rhabdomyosarcoma and sarcoma of liver that are located_in the liver."} -{"_id": 1769, "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed."} -{"_id": 1772, "text": "A skin disease characterized by cutaneous pigmentation, premature graying, dystrophy of the nails, leukoplakia of the oral mucosa, continuous lacrimation due to atresia of the lacrimal ducts, often thrombocytopenia, anemia, testicular atrophy in the male carriers and predisposition to cancer."} -{"_id": 1775, "text": "A glioblastoma multiforme that is characterized by a prevalence of bizarre, multinucleated giant cells."} -{"_id": 1778, "text": "A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the MMP13 gene which results_in a pear-shaped vertebrae, abnormal metaphyseal changes, and genu varum deformities."} -{"_id": 1781, "text": "A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina."} -{"_id": 1784, "text": "An anal carcinoma that represents a group of cancers that are frequently diagnosed in people with HIV/AIDS."} -{"_id": 1787, "text": "A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye; symptoms include vision loss."} -{"_id": 1790, "text": "An American histoplasmosis that results_in inflammation located_in retina, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and results_in_formation_of lesions."} -{"_id": 1793, "text": "An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40."} -{"_id": 1796, "text": "A viral infectious disease that results_in infection located_in respiratory system, located_in gastrointestinal system, and located_in nervous system of dogs, foxes, wolves, coyotes, raccoons, skunks, and ferrets, has_material_basis_in Canine distemper virus, which is transmitted_by droplet spread of respiratory secretions from an infected animal. The infection has_symptom fever, has_symptom nasal discharge, has_symptom coughing, has_symptom vomiting, has_symptom diarrhea, has_symptom seizures, and has_symptom twitching."} -{"_id": 1799, "text": "A sarcoma and malignant tumor of small intestine that is located_in the small intestine."} -{"_id": 1802, "text": "An achromatopsia that is characterized by severely impaired color discrimination, low visual acuity, nystagmus, photophobia due to the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina and has_material_basis_in recessive X-linked inheritance."} -{"_id": 1805, "text": "An aortic disease that is characterized by an absence of an opening from the left ventricle of the heart into the aorta."} -{"_id": 1808, "text": "An urea cycle disorder that involves a mutated and ineffective form of the enzyme ornithine transcarbamylase."} -{"_id": 1811, "text": "A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it."} -{"_id": 1814, "text": "A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts."} -{"_id": 1817, "text": "A liposarcoma that is located_in the larynx."} -{"_id": 1820, "text": "A malignant retroperitoneal cancer and sarcoma that is located_in the retroperitoneal space."} -{"_id": 1823, "text": "A colon cancer that arises from transformed cells of mesenchymal origin and is located_in the colon."} -{"_id": 1826, "text": "A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin."} -{"_id": 1829, "text": "A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva."} -{"_id": 1832, "text": "A Charcot-Marie-Tooth disease characterized by abnormalities in the axon of the peripheral nerve cell."} -{"_id": 1835, "text": "A coccidiosis that involves infection of the intestine with the parasitic protozoan Cyclospora cayetanensis, which is transmitted by contaminated food and water. The symptoms include watery diarrhea, anorexia, weight loss, abdominal pain, nausea and vomiting, myalgias, low-grade fever, and fatigue."} -{"_id": 1838, "text": "A non-Hodgkin lymphoma that has_material_basis_in mature T lymphocytes and natural killer cells."} -{"_id": 1841, "text": "A fibrosarcoma of soft tissue and sarcoma of liver that is located_in the liver."} -{"_id": 1844, "text": "A cutaneous mycosis that results_in fungal infection located_in skin, located_in hair and located_in nail, has_material_basis_in Basidiomycota phylum members."} -{"_id": 1847, "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools."} -{"_id": 1850, "text": "A skin cancer that has_material_basis_in melanocytes."} -{"_id": 1853, "text": "An Epstein-Barr virus infectious disease that results_in inflammation, located_in brain, has_material_basis_in Human herpesvirus 4 and has_symptom seizures, has_symptom altered consciousness, and has_symptom cerebellar ataxia."} -{"_id": 1856, "text": "A syndrome characterize by seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance. It is caused by homozygous or compound heterozygous mutation in the KCNJ10 gene on chromosome 1q23."} -{"_id": 1859, "text": "A breast benign neoplasm comprised of fibrous and glandoular tissues located_in breast."} -{"_id": 1862, "text": "A syndrome characterized by microcornea, microphthalmia, anterior-segment dysgenesis, cataract, coloboma of various parts of the eye, abnormalities of the retinal pigment epithelium, and rod-cone dystrophy and a particular cleft ear lobule."} -{"_id": 1865, "text": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus."} -{"_id": 1868, "text": "A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning."} -{"_id": 1871, "text": "A labyrinthitis induced by alcohol, drug ingestion, or occasionally, inhaled substances that are toxic to the inner ear. Drugs like aminoglycosides, furosemide, ethacrynic acid, acetylsalicyclic acid, amiodarone, quinine, cisplatinum, barbiturates, quinine, anti-Alzheimer's medications, anticonvulsants, antidepressants, and anxiolytics can be ototoxic."} -{"_id": 1874, "text": "A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."} -{"_id": 1877, "text": "An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face."} -{"_id": 1880, "text": "An extraosseous chondrosarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage and is characterized by a marked abundance of extracellular mucoid (myxoid) matrix."} -{"_id": 1883, "text": "A mediastinal cancer that has_material_basis_in neural cells."} -{"_id": 1886, "text": "An epididymis cancer that derives_from epithelial cells of glandular origin."} -{"_id": 1889, "text": "A skin carcinoma affecting basal cells."} -{"_id": 1892, "text": "An osteochondrosis that results_in death and fracture located_in hip joint."} -{"_id": 1895, "text": "A brain disease characterized by marked reduction of nearly all motor functions including facial expressions, gestures and speech output, but with some degree of alertness."} -{"_id": 1898, "text": "An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column."} -{"_id": 1901, "text": "A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain."} -{"_id": 1904, "text": "A syndrome characterized by intellectual disability, focal dystonia of the hands and dysarthria."} -{"_id": 1907, "text": "A lymphopenia that is caused by a reduction of CD4+ T lymphocytes."} -{"_id": 1910, "text": "A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep."} -{"_id": 1913, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding."} -{"_id": 1916, "text": "A syndrome characterized by childhood hypotonia, a distinctive facial appearance, speech impediments and developmental disability, as well as epilepsy, congenital and urogenetic defects, microcephaly, corpulence, and psychiatric disorders. It is caused either by a microdeletion in the chromosome region 9q34.3 or by a point mutation in the EHMT1 gene located in that region."} -{"_id": 1919, "text": "An asthma that is characterized by chronic nonproductive cough without shortness of breath."} -{"_id": 1922, "text": "A syndrome characterized_by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids, and with alopecia."} -{"_id": 1925, "text": "A Pseudocoelomata infectious disease that involves infection by parasitic worms known as thorny-headed worms, characterized by the presence of an evertable proboscis, armed with spines, which is used to pierce and hold the gut wall of the host."} -{"_id": 1928, "text": "A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles."} -{"_id": 1931, "text": "An aortic valve disease that is characterized by leaking of the aortic valve of the heart causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle."} -{"_id": 1934, "text": "A bipolar disorder that is characterized by at least one hypomanic episode and at least one major depressive episode; with this disorder, depressive episodes are more frequent and more intense than manic episodes."} -{"_id": 1937, "text": "A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable."} -{"_id": 1940, "text": "A cervix carcinoma that has_material_basis_in squamous cells of the cervix."} -{"_id": 1943, "text": "A nervous system cancer that is located_in the peripheral nervous system."} -{"_id": 1946, "text": "A cerebral degeneration characterized by dysfunction of the white matter of the brain."} -{"_id": 1949, "text": "An adrenalcortical carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin."} -{"_id": 1952, "text": "A pulmonary blastoma that derives_from the lung or pleural cavity."} -{"_id": 1955, "text": "A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has_material_basis_in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene."} -{"_id": 1958, "text": "An electroclinical syndrome with onset in infancy occurring between birth and one year of age."} -{"_id": 1961, "text": "A Paramyxoviridae infectious disease that results_in infection in domestic animals and humans, has_material_basis_in Henipavirus, which is transmitted_by direct contact with the urine, feces, and nasal secretions of an infected animal."} -{"_id": 1964, "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, located_in liver, has_material_basis_in Hepeviridae viruses."} -{"_id": 1967, "text": "A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage."} -{"_id": 1970, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine."} -{"_id": 1973, "text": "An intraocular retinoblastoma that effects children."} -{"_id": 1976, "text": "A blepharitis that is characterized by the dual combination of conjunctivitis with blepharitis."} -{"_id": 1979, "text": "An amino acid metabolic disorder that involves deficiency in histidine."} -{"_id": 1982, "text": "A congenital hemolytic anemia characterized by the production of red blood cells with a sphere shape, rather than the normal biconcave disk shape."} -{"_id": 1985, "text": "A choroid plexus cancer that has_material_basis_in epithelial cells of the choroid plexus."} -{"_id": 1988, "text": "An atrophic glossitis that is characterized as an inflammatory condition of the mucous membrane of the tongue, usually on the dorsal surface."} -{"_id": 1991, "text": "An embryoma and malignant neoplasm of lung that derives_from tissues of the lung and derives_from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). It is most commonly effects children."} -{"_id": 1994, "text": "A gonadal dysgenesis that is characterized by a normal 46,XY karyotype along with a progressive loss of germ cells on the developing gonads of an embryo."} -{"_id": 1997, "text": "A toxoplasmosis that is caused by the protozoan Toxoplasma gondii which is recognized as pathogen in immunocompromised patients. Microscopy of the lung shows fibrinous exudate, and necrotic areas with intra and extracellular tachizoites along the interstitium and alveolar spaces. The symptoms are cough, shortness of breath, high fever and rales."} -{"_id": 2000, "text": "A cholera that involves infection of the intestine caused by Vibrio cholerae serogroup O1 biovar El Tor."} -{"_id": 2003, "text": "A acute transudative otitis media involving thick, viscid and mucuslike fluid effusion due to which the drum appears blue in color."} -{"_id": 2006, "text": "A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and necrotizing vasculitis of venules and hemorrhage, and edema."} -{"_id": 2009, "text": "A otitis which involves inflammation of the inner ear."} -{"_id": 2012, "text": "A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord."} -{"_id": 2015, "text": "A Pneumocystis jirovecii pneumonia that is_a disease associated with AIDS has_material_basis_in Pneumocystis jirovecii located_in lungs affecting individuals with HIV."} -{"_id": 2018, "text": "An embryonal cancer that is a type of germ cell tumour that is located_in the ovaries or located_in the testes."} -{"_id": 2021, "text": "An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit."} -{"_id": 2024, "text": "An urethra cancer that is characterized by cancer cells forming in the renal pelvis and ureter."} -{"_id": 2027, "text": "A Flaviviridae infectious disease that results_in infection, has_material_basis_in Hepacivirus, which is transmitted_by sexual contact, or transmitted_by blood transfusion."} -{"_id": 2030, "text": "A sphenoid sinusitis which lasts for less than 4 weeks."} -{"_id": 2033, "text": "An autosomal genetic disease characterized by short stature, bachycephaly and other facial abnormalities, brachydactyly, joint stiffness and distinctive ocular abnormalities."} -{"_id": 2036, "text": "A primary ciliary dyskinesia that results from dysfunction of the cilia during embryologic development and is characterized by the triad of sinusitis, bronchiectasis and situs inversus with dextrocardia."} -{"_id": 2039, "text": "A leukemia that is located_in the spleen. It results_in an enlargement of the leukemia."} -{"_id": 2042, "text": "A pulmonary tuberculosis in which tissue deep in the lungs becomes thick and stiff (scarred)."} -{"_id": 2045, "text": "A connective tissue disease that results in increasing fibrous constriction and ultimately in spontaneous amputation of the toes and especially the little toes. A painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous amputation (autoamputation) a few years later."} -{"_id": 2048, "text": "A primary systemic mycosis that results_in fungal infection located_in skin and located_in subcutaneous tissue, and located_in lymphatic vessel through direct inoculation from wood splinters or hay, has_material_basis_in Sporothrix schenckii, a dimorphic fungus, which results_in_formation_of erythematous papulonodular lesions at the site of implantation and along the lymphangitic channels which soon become palpable and ulcerate."} -{"_id": 2051, "text": "A brain oligodendroglioma located_in the corpus callosum."} -{"_id": 2054, "text": "A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults."} -{"_id": 2057, "text": "A non-suppurative otitis media which involves obstruction of the collecting lymphatic tubules of the middle ear and eustachian tube as they drain to the retropharyngeal lymphatics. Retraction of the tympanic membrane is also observed."} -{"_id": 2060, "text": "A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits."} -{"_id": 2063, "text": "An ovarian cancer that originates in the germ (egg) cells of the ovary."} -{"_id": 2066, "text": "A hematologic cancer and central nervous system neoplasm that is located_in the central nervous system."} -{"_id": 2069, "text": "A genetic disease that is the result of one or more abnormal alleles and may be dominant (a single copy of the abnormal allele is sufficient to give rise to the disease), semi-dominant, or recessive (requiring both copies of the gene to have an abnormal allele)."} -{"_id": 2072, "text": "A malignant glioma that is derived from ependymal cells, a type of glial cell, located_in ventricle lining within the central part of the brain."} -{"_id": 2075, "text": "A malignant neoplasm that is manifested in the pelvic region."} -{"_id": 2078, "text": "A disease that has an etiology of chemical exposure or exposure to other environmental factors excluding infectious agents."} -{"_id": 2081, "text": "An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues."} -{"_id": 2084, "text": "A suppurative otitis media which is persistent and long-lasting."} -{"_id": 2087, "text": "A musculoskeletal system benign neoplasm that is located_in connective tissue."} -{"_id": 2090, "text": "A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris."} -{"_id": 2093, "text": "A crustacean allergy triggered by Litopenaeus vannamei."} -{"_id": 2096, "text": "A viral infectious disease that results_in infection located_in joint, has_material_basis_in O'nyong-nyong virus, which is transmitted_by Anopheles gambiae, and transmitted_by Anopheles funestus mosquitoes. The infection has_symptom fever, has_symptom arthralgia, has_symptom rash, and has_symptom lymphadenitis."} -{"_id": 2099, "text": "A bone development disease that results_in defective ossification of located_in bone."} -{"_id": 2102, "text": "A viral infectious disease that results_in infection located_in joint, has_material_basis_in Barmah Forest virus, which is transmitted_by mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash."} -{"_id": 2105, "text": "A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection."} -{"_id": 2108, "text": "An autosomal dominant disease that is characterized by multiple bluish cutaneous or mucosal venous lesions."} -{"_id": 2111, "text": "A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years."} -{"_id": 2114, "text": "A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage."} -{"_id": 2117, "text": "An anogenital venereal wart that results_in infection located_in skin of anus, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during anal sex with an infected partner. The infection has_symptom anal warts."} -{"_id": 2120, "text": "A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies."} -{"_id": 2123, "text": "A superficial mycosis that results_in fungal infection of the outermost layer located_in skin and located_in hair shaft, has_material_basis_in Basidiomycota phylum members."} -{"_id": 2126, "text": "An epilepsy that is characterized by frequent febrile seizures with onset before 1 year."} -{"_id": 2129, "text": "A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia."} -{"_id": 2132, "text": "An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located_in the cells that line the blood vessels within the breast or underarm area."} -{"_id": 2135, "text": "A food allergy triggered by a plant fruit product."} -{"_id": 2138, "text": "An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons."} -{"_id": 2141, "text": "A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis."} -{"_id": 2144, "text": "A parasitic protozoa infectious disease that involves infection caused by a free-living ameba Balamuthia mandrillaris resulting in encephalitis and skin lesions in humans and animals."} -{"_id": 2147, "text": "A ciliopathy that is characterized by renal cystic dysplasia, occipital encephalocele, polydactyly (post axial), hepatic developmental defects, and pulmonary hypoplasia."} -{"_id": 2150, "text": "A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity."} -{"_id": 2153, "text": "An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located_in the liver."} -{"_id": 2156, "text": "A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods."} -{"_id": 2159, "text": "A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences."} -{"_id": 2162, "text": "A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together."} -{"_id": 2165, "text": "A rectum cancer that derives_from epithelial cells of glandular origin."} -{"_id": 2168, "text": "A gastrointestinal benign neoplasm that is a located_in the salivary glands."} -{"_id": 2171, "text": "A purine-pyrimidine metabolic disorder characterized by deficiency of xanthine oxidase, resulting in excretion of large amounts of xanthine in the urine and the formation of xanthine stones."} -{"_id": 2174, "text": "A yaws that results in initial papule at the site of entry of bacteria. Without treatment, this is followed by disseminated skin lesions over the body. Bone pain and bone lesions may also occur."} -{"_id": 2177, "text": "A leprosy that results in small numerous red irregularly shaped plaques."} -{"_id": 2180, "text": "An artery disease that is characterized by degeneration of the cells composing the aortic wall."} -{"_id": 2183, "text": "A sleep disorder that involves recurring bouts of excessive amounts of sleepiness."} -{"_id": 2186, "text": "An organ system cancer located_in the ear and characterized by uncontrolled cellular proliferation of the auditory organs."} -{"_id": 2189, "text": "Emphysematous cholecystitis is a bacterial infectious disease consisting of an inflammation of the gallbladder characterized by air-filled expansions in interstitial or subcutaneous tissues."} -{"_id": 2192, "text": "A type of ALS with juvenile onset caused_by homozygous or compound heterozygous mutation in the spatacsin gene (SPG11) on chromosome 15q21."} -{"_id": 2195, "text": "A gastrointestinal system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct."} -{"_id": 2198, "text": "A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of Toxocara canis or Toxocara cati. The larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions."} -{"_id": 2201, "text": "A gallbladder carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 2204, "text": "A non-suppurative otitis media and eustachian tube disorder with a sudden onset and a short course."} -{"_id": 2207, "text": "An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness."} -{"_id": 2210, "text": "A colon carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 2213, "text": "A heavy chain disease that results from an overproduction of gamma antibody (IgG)."} -{"_id": 2216, "text": "A lipid storage disease that is characterized by the desposition of yellowish cholesterol-rich material in tendons or other body parts."} -{"_id": 2219, "text": "An aspiration pneumonia caused by anaerobic bacteria like Bacteroides fragilis, Peptostreptococcus, anaerobic streptococci, Fusobacterium species (Fusobacterium nucleatum and Fusobacterium necrophoram). Lung abscess and empyema are diagnosed in this disease."} -{"_id": 2222, "text": "A lymph node cancer that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures of the lymph nodes. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes."} -{"_id": 2225, "text": "A synovium cancer which develops in the synovial membrane of the joints."} -{"_id": 2228, "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse."} -{"_id": 2231, "text": "A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use."} -{"_id": 2234, "text": "An artery disease that is characterized by dysfunction of the blood vessels supplying the brain."} -{"_id": 2237, "text": "A tyrosinemia that has_material_basis_in deficiency of the enzyme fumarylacetoacetate hydrolase resulting in an increase in fumarylacetoacetate which inhibits previous steps in tyrosine degradation leading to an accumulation of tyrosine in the body."} -{"_id": 2240, "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis."} -{"_id": 2243, "text": "A gastrointestinal system disease that is located_in the esophagus."} -{"_id": 2246, "text": "A Varicellovirus infectious disease that results_in pain located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after the primary infection, has_symptom severe pain, has_symptom sensitivity to light touch, has_symptom muscle weakness, has_symptom paralysis, and has_symptom itching."} -{"_id": 2249, "text": "A spina bifida characterized by protrusion of the spinal cord through an opening, covered by meningeal membranes."} -{"_id": 2252, "text": "An upper respiratory tract disease which involves inflammation of both larynx and pharynx."} -{"_id": 2255, "text": "A gastrointestinal system cancer that has_material_basis_in epithelial cells."} -{"_id": 2258, "text": "A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia."} -{"_id": 2261, "text": "A neurilemmoma with a predominantly cellular growth but no Verocay bodies."} -{"_id": 2264, "text": "Encephalitis is a nervous system infectious disease characterized as an acute inflammation of the brain. The usual cause is a viral infection, but bacteria can also cause it. Cases can range from mild to severe. For mild cases, you could have flu-like symptoms. Serious cases can cause severe headache, sudden fever, drowsiness, vomiting, confusion and seizures."} -{"_id": 2267, "text": "A chondrosarcoma that is located_in exclusively soft tissue."} -{"_id": 2270, "text": "An autosomal recessive disease that is a genetically heterogeneous encephalopathy characterized in its most severe form by cerebral atrophy, leukodystrophy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infections."} -{"_id": 2273, "text": "A selective immunoglobulin deficiency disease thatis a dysgammaglobulinemia resulting from decreased levels of immunoglobulin M (IgM) production to roduction of other antibodies."} -{"_id": 2276, "text": "A vaginal cancer that has_material_basis_in epithelial cells."} -{"_id": 2279, "text": "A nephroblastoma that recurs over time."} -{"_id": 2282, "text": "A syndrome that affects growth, cranial development, hair growth and dental development."} -{"_id": 2285, "text": "An adrenal admenoma characterized by over production of aldosterone."} -{"_id": 2288, "text": "An American histoplasmosis that results_in inflammation located_in pericardium, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom pleural effusions, has_symptom chest pain and has_symptom cough."} -{"_id": 2291, "text": "A connective tissue benign neoplasm that is characterized by the development of benign tumors in the skin, striated muscles, bones, and in exceptional cases, visceral organs."} -{"_id": 2294, "text": "A dysostosis characterized by cranium bifidum, severe hypertelorism, median cleft lip and palate, nasal bifurcation, brachycephaly, large fontanelle, tibial hemimelia, preaxial polydactyly of the feet and brain malformations."} -{"_id": 2297, "text": "A candidiasis that results_in inflammation located_in endocardium, has_material_basis_in Candida, which favors previously damaged or prosthetic heart valves. The source is often an intravascular catheter or contaminated equipment used for illicit intravenous drug injection. The illness has_symptom fever, has_symptom murmur, has_symptom congestive heart failure, has_symptom anemia, and has_symptom splenomegaly."} -{"_id": 2300, "text": "A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium."} -{"_id": 2303, "text": "A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop)."} -{"_id": 2306, "text": "An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent."} -{"_id": 2309, "text": "A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system."} -{"_id": 2312, "text": "A tertiary syphilis that is caused by the spirochetal bacterium Treponema pallidum subspecies pallidum. It is a sexually transmitted disease although congenital syphilis can also occur. Treponema infection of the lung leads to a fibrous induration spreading from the roots of the lungs. Ulcerations occur in the superficial tissues, while in the deep tissues gummata are formed. Symptoms include dry cough, hemoptysis, hemorrhage, dyspnea, pain in the chest, loss of weight and slight fever."} -{"_id": 2315, "text": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior."} -{"_id": 2318, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi . Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur."} -{"_id": 2321, "text": "An embryonal cancer and bone cancer and mesenchymal cell neoplasm that is located_in the notochord."} -{"_id": 2324, "text": "A germ cell cancer that derives_from cells that give rise to egg cells."} -{"_id": 2327, "text": "A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint."} -{"_id": 2330, "text": "An X-linked disease characterized by pre- and postnatal overgrowth and craniofacial, skeletal, cardiac and renal abnormalities."} -{"_id": 2333, "text": "A tularemia that results_in bacteremia and has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom malaise, and has_symptom weight loss."} -{"_id": 2336, "text": "A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis."} -{"_id": 2339, "text": "An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea."} -{"_id": 2342, "text": "An ancylostomiasis that involves parasitic infection of animals and humans by Ancylostoma ceylanicum larvae, which invade percutaneously and migrate to the intestine."} -{"_id": 2345, "text": "A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH)."} -{"_id": 2348, "text": "An acrodermatitis characterized by a chronically progressive course, leading to widespread atrophy of the skin. It is a clinical manifestation of Lyme borreliosis."} -{"_id": 2351, "text": "A pineal gland neoplasm located_in the brain."} -{"_id": 2354, "text": "An integumentary system disease that is located_in hair."} -{"_id": 2357, "text": "A Varicellovirus infectious disease that results_in infection in cattle, located_in upper respiratory tract, and located_in genital tract, has_material_basis_in Bovine herpesvirus 1, has_symptom nasal discharge, has_symptom fever, has_symptom abortion, and has_symptom conjunctivitis."} -{"_id": 2360, "text": "A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide."} -{"_id": 2363, "text": "An external ear cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 2366, "text": "A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities."} -{"_id": 2369, "text": "A dystonia that affects two or more adjacent parts of the body."} -{"_id": 2372, "text": "A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption."} -{"_id": 2375, "text": "A fruit allergy triggered by Cucumis melo plant fruit food product."} -{"_id": 2378, "text": "A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated."} -{"_id": 2381, "text": "A fruit allergy triggered by Prunus armeniaca plant fruit food product."} -{"_id": 2384, "text": "A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent."} -{"_id": 2387, "text": "An egg allergy triggered by Gallus gallus eggs."} -{"_id": 2390, "text": "A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system."} -{"_id": 2393, "text": "A syndromic intellectual characterized by an X-linked inheritance pattern."} -{"_id": 2396, "text": "A coxsackie meningitis that results_in inflammation located_in meningeal cluster, has_material_basis_in Human echovirus 30, or has_material_basis_in Human echovirus 9, which is transmitted_by ingestion of food contaminated with feces, transmitted_by droplet spread of oronasal secretions from infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom headache, has_symptom photophobia and has_symptom neck stiffness."} -{"_id": 2399, "text": "A otitis media which involves inflammation of the middle ear with infected effusion containing pus."} -{"_id": 2402, "text": "A drug allergy triggered by a beta-lactam (\u03b2-lactam)."} -{"_id": 2405, "text": "A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body."} -{"_id": 2408, "text": "An autosomal recessive disease that is characterized by the combination of hypertelorism, cleft lip and palate and microtia."} -{"_id": 2411, "text": "A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration."} -{"_id": 2414, "text": "A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure."} -{"_id": 2417, "text": "A bone marrow cancer that results_in the overproduction of white blood cells."} -{"_id": 2420, "text": "A myeloma and blood platelet disease that is characterized by the presence of high platelet counts in the blood."} -{"_id": 2423, "text": "A calcinosis that is the calcification or a bony hardening of ligaments in areas where they attach to your spine."} -{"_id": 2426, "text": "A sideroblastic anemia characterized by an autosomal dominant inheritance pattern."} -{"_id": 2429, "text": "An embryonal testis carcinoma that occurs in children."} -{"_id": 2432, "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 2435, "text": "An actinomycosis that results_in infection, has_material_basis_in Actinomyces israelii or has_material_basis_in Actinomyces gerencseriae. It results in lung cavities, lung nodules, and pleural effusion. The infection has_symptom chest pain, has_symptom cough with sputum, has_symptom fever, has_symptom lethargy, has_symptom night sweats, has_symptom shortness of breath, has_symptom weight loss, and has_symptom draining of sinuses."} -{"_id": 2438, "text": "A mitochondrial metabolism disease characterized by motor disability, with ataxia, apraxia, dystonia, and dysarthria, associated with necrotic lesions throughout the brain and has material basis in mutation in the TTC19 gene on chromosome 17. It has an autosomal recessive inheritance pattern."} -{"_id": 2441, "text": "A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens."} -{"_id": 2444, "text": "A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage."} -{"_id": 2447, "text": "An endocervical carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 2450, "text": "A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria)."} -{"_id": 2453, "text": "A T cell deficiency disease that is the result of a large deletion of chromosome 22 which includes the DGS gene needed for development of the thymus and related glands with subsequent lack of T-cell production."} -{"_id": 2456, "text": "A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries."} -{"_id": 2459, "text": "A eustachian tube disorder with a wider eustachian tube which allows a larger bolus of bacteria-laden material from the nasopharynx during an infection to enter the middle ear, causing a more fulminant infection."} -{"_id": 2462, "text": "A B cell deficiency that is caused by a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement."} -{"_id": 2465, "text": "A respiratory system disease which involves the upper respiratory tract."} -{"_id": 2468, "text": "A germ cell cancer that derives_from germ cells that are found in areas of the body other than the ovary or testicle. The tumors originate in the sperm forming cells in the testicles or egg producing cells in the ovary."} -{"_id": 2471, "text": "A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death."} -{"_id": 2474, "text": "A transitional cell carcinoma that has sarcoma-like components arising from the malignant transitional epithelium."} -{"_id": 2477, "text": "A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality."} -{"_id": 2480, "text": "A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope."} -{"_id": 2483, "text": "A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly."} -{"_id": 2486, "text": "A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching."} -{"_id": 2489, "text": "A globe disease that is characterized by inflammation of the inside of the eye."} -{"_id": 2492, "text": "A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot."} -{"_id": 2495, "text": "An osteosclerosis that results_in numerous bone islands located_in skeleton."} -{"_id": 2498, "text": "A pervasive developmental disease that is a neurological and developmental disorder that mostly occurs in females and is caused_by a mutation on the MECP2 gene on the X chromosome. Infants with Rett syndrome seem to grow and develop normally at first, but then stop developing and even lose skills and abilities."} -{"_id": 2501, "text": "A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch."} -{"_id": 2504, "text": "A chondroid chordoma and chordoma of the clivus that is located_in the clivus."} -{"_id": 2507, "text": "A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality."} -{"_id": 2510, "text": "An anthrax disease that results_in infection located_in lung lymph nodes brought on by breathing in the spores of the bacteria Bacillus anthracis. The first symptoms of inhalation anthrax are like cold or flu symptoms and can include a sore throat, mild fever and muscle aches. Later symptoms include cough, chest discomfort, shortness of breath, tiredness and muscle aches."} -{"_id": 2513, "text": "An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. It is caused by mutations in the GNAS1 gene."} -{"_id": 2516, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis."} -{"_id": 2519, "text": "A hereditary ataxia characterized by sporadic bouts of ataxia with or without continuous muscle movement."} -{"_id": 2522, "text": "A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by fungal infection in immunocompromised patients."} -{"_id": 2525, "text": "A thyroid cancer that is located_in the supporting cells of the thyroid."} -{"_id": 2528, "text": "A larynx cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic mesoderm."} -{"_id": 2531, "text": "A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting."} -{"_id": 2534, "text": "An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs."} -{"_id": 2537, "text": "An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions."} -{"_id": 2540, "text": "An eccrine sweat gland cancer that derives_from epithelial cells of glandular origin."} -{"_id": 2543, "text": "A dermatitis that is an inflammatory skin condition resulting in flaky, white to yellowish scales on oily areas such as the scalp or inside the ear, which is caused due to a combination of an over production of skin oil and irritation from a yeast Malassezia furfur. The symptoms include itching, skin lesions and scales, redness, plaques and hair loss."} -{"_id": 2546, "text": "Motility-related diarrhea is a diarrhea which is caused by the rapid movement of food through the intestines (hypermotility). If the food moves too quickly through the GI tract, there is not enough time for sufficient nutrients and water to be absorbed."} -{"_id": 2549, "text": "An opportunistic mycosis that results_in fungal infection located_in nail, has_material_basis_in Scopulariopsis brevicaulis and has_symptom rough nail, and has_symptom crumbly nail which can separate from the nail bed."} -{"_id": 2552, "text": "A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells."} -{"_id": 2555, "text": "A bone disease that results_in inflammation of the located_in bone."} -{"_id": 2558, "text": "A xanthomatosis that is characterized by a deficiency in the production of the bile acid, chenodeoxycholic acid that has_material_basis_in autosomal recessive inheritance and results in cholestanol deposition in the brain and other tissues and with elevated levels of cholesterol in plasma."} -{"_id": 2561, "text": "An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges."} -{"_id": 2564, "text": "A germinoma that has_material_basis_in cells that make sperm and eggs."} -{"_id": 2567, "text": "An extrinsic allergic alveolitis which is caused by inhalation of fungal spores of Aspergillus clavatus and Aspergillus fumigatus from moldy barley."} -{"_id": 2570, "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system."} -{"_id": 2573, "text": "An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids."} -{"_id": 2576, "text": "An Enterovirus infectious disease that results_in inflammation located_in brain, has_material_basis_in polioviruses, which are transmitted_by ingestion of food contaminated with feces. The infection has_symptom tremors, has_symptom nystagmus, has_symptom loss of conjugate eye movements, has_symptom muscle rigidity, has_symptom hemiparesis, and has_symptom coma."} -{"_id": 2579, "text": "A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with cysts and papillary endophytic projections."} -{"_id": 2582, "text": "A hypobammaglobulinemia that is a B cell deficiency caused by a mutation a cytoplasmic linker or adaptor protein that plays a critical role in B cell development, the B cell linker protein (BLNK) gene. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. The BLNK gene is associated with intracellular calcium mobilization, essential for cell activation."} -{"_id": 2585, "text": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body."} -{"_id": 2588, "text": "A uterine body mixed cancer that has_material_basis_in both endometrial carcinoma and sarcoma."} -{"_id": 2591, "text": "A viral infectious disease that results_in infection, has_material_basis_in Rubella virus, which is transmitted_by direct contact with the infected person through coughing and sneezing, and transmitted_by congenital method."} -{"_id": 2594, "text": "A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions."} -{"_id": 2597, "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain."} -{"_id": 2600, "text": "A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue forming serous lesions."} -{"_id": 2603, "text": "A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes."} -{"_id": 2606, "text": "A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible."} -{"_id": 2609, "text": "A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth."} -{"_id": 2612, "text": "An angiosarcoma that affects children."} -{"_id": 2615, "text": "A syndrome characterized by classical lissencephaly and distinct facial features. Visible and submicroscopic deletions of 17p13.3, including the LIS1 gene, are found in almost 100% of patients."} -{"_id": 2618, "text": "A primary systemic mycosis that results_in fungal infection located_in lung, has_material_basis_in Sporothrix schenckii, a dimorphic fungus, which is transmitted_by airborne spores and has_symptom productive cough, has_symptom nodules and cavitations of the lungs, has_symptom fibrosis, and has_symptom swollen hilar lymph nodes."} -{"_id": 2621, "text": "A"} -{"_id": 2624, "text": "An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection."} -{"_id": 2627, "text": "A brain cancer that has_material_basis_in glial cells."} -{"_id": 2630, "text": "A nephroblastoma that results_in an unfavorable appearance under the microscope. They are characterized by a cell nuclei that tends to be very large and distorted."} -{"_id": 2633, "text": "A leiomyosarcoma and sarcoma of the mediastinum that derive_from smooth muscle and are usually located_in the esophagus or located_in the main vessels."} -{"_id": 2636, "text": "A gallbladder sarcoma that is located_in the gallbladder."} -{"_id": 2639, "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Caliciviridae viruses."} -{"_id": 2642, "text": "A salivary gland carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes."} -{"_id": 2645, "text": "A ssDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Parvoviridae viruses."} -{"_id": 2648, "text": "A liposarcoma that is located_in the kidney."} -{"_id": 2651, "text": "A genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature."} -{"_id": 2654, "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which produce mucin."} -{"_id": 2657, "text": "A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood."} -{"_id": 2660, "text": "A non-small cell lung carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 2663, "text": "A carcinoma that is able to grow at sites distant from the primary site of origin."} -{"_id": 2666, "text": "A syndrome that is characterized by congenital joint contractures, renal tubular dysfunction, cholestasis, severe failure to thrive, ichthyosis, and a defect in platelet alpha-granule biogenesis, caused_by homozygous or compound heterozygous mutation located_in VPS33B gene or caused_by homozygous or compound heterozygous mutation in the VIPAR gene on chromosome 14q24.3.."} -{"_id": 2669, "text": "An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop."} -{"_id": 2672, "text": "A germ cell cancer that occurs in many forms."} -{"_id": 2675, "text": "An idiopathic interstitial pneumonia which involves diffuse interstitial infiltration of involved areas mostly with T lymphocytes, plasma cells, and macrophages. Lymphoid hyperplasia is frequently seen. Onset is often slow with gradually increasing cough and breathlessness over 3 or more years. Fever, weight loss, chest pain, and arthralgia are occasionally found. Crackles may be detected as the disease progresses."} -{"_id": 2678, "text": "A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds."} -{"_id": 2681, "text": "A Q fever that involves inflammation of the liver caused by Coxiella burnetti, which results in the formation of granulomas. The symptoms include fever, malaise, hepatomegaly with right upper abdominal pain, and jaundice."} -{"_id": 2684, "text": "A spotted fever that has_material_basis_in Rickettsia honei, which is transmitted_by cayenne ticks (Amblyomma cajennense). The infection has_symptom mild spotted fever, has_symptom eschar and has_symptom adenopathy."} -{"_id": 2687, "text": "A bone cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 2690, "text": "An idiopathic interstitial pneumonia that is characterized by the accumulation of bronchiolocentric alveolar macrophages in alveolar spaces and interstitial inflammation and involves mild bronchiolar fibrosis and chronic inflammation."} -{"_id": 2693, "text": "A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia."} -{"_id": 2696, "text": "A hypersensitivity reaction type IV disease that results from a proliferation of cells producing immunoglobulin heavy chains."} -{"_id": 2699, "text": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences."} -{"_id": 2702, "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Inkoo virus, which is transmitted_by Ochlerotatus communis mosquito. The infection has_symptom stiff neck, has_symptom lethargy, has_symptom headache, has_symptom fever, and has_symptom seizures."} -{"_id": 2705, "text": "Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself."} -{"_id": 2708, "text": "A (-)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Orthomyxoviridae family viruses, which are transmitted_by droplet spread of respiratory secretions or transmitted_by contaminated fomites."} -{"_id": 2711, "text": "A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications."} -{"_id": 2714, "text": "A Paramyxoviridae infectious disease that results_in infection in dogs, seals, cattle and humans, has_material_basis_in Morbillivirus."} -{"_id": 2717, "text": "A leukemia that has_material_basis_in lymphoblasts (immature white blood cells)."} -{"_id": 2720, "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the prostate gland caused by Trichomonas vaginalis."} -{"_id": 2723, "text": "A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum."} -{"_id": 2726, "text": "A nonparalytic poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 2, which is transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms."} -{"_id": 2729, "text": "A vascular disease that is located_in a vein."} -{"_id": 2732, "text": "A congenital heart disease characterized by abnormal development of the left-sided structures of the heart."} -{"_id": 2735, "text": "An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs."} -{"_id": 2738, "text": "A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance."} -{"_id": 2741, "text": "An enteroinvasive Escherichia coli infectious disease that involves infection of the intestine caused by enteroinvasive Escherichia coli. The symptoms include fever, bloody diarrhea, and dehydration."} -{"_id": 2744, "text": "An autosomal recessive disease characterized by sun sensitivity, short stature, predisposition to the development of cancer and genomic instability."} -{"_id": 2747, "text": "Paronychia is a nail infectious disease where there is an often-tender bacterial or fungal hand infection or foot infection due to either bacteria or fungus (Candida albicans) where the nail and skin meet at the side or the base of a finger or toe nail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia). Puss is usually present, along with gradual thickening and browning discoloration of the nail plate."} -{"_id": 2750, "text": "A pneumonia accompanied by inflammation of the pleura and accumulation of pus in the pleural space caused by bacteria."} -{"_id": 2753, "text": "A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells."} -{"_id": 2756, "text": "A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions."} -{"_id": 2759, "text": "An acquired immunodeficiency syndrome that results_in involuntary loss of more than 10% of body weight, plus more than 30 days of either diarrhea, or weakness and fever, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2."} -{"_id": 2762, "text": "A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion."} -{"_id": 2765, "text": "A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and is caused by mutations in the CTNS gene, located on chromosome 17."} -{"_id": 2768, "text": "A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food."} -{"_id": 2771, "text": "A sarcoma and malignant tumor of rectum that is located_in the rectum."} -{"_id": 2774, "text": "A Rhabditida infectious disease that involves parasitic infection of gastrointestinal tracts of ruminants, horses, cats, dogs, swine and humans by nematodes belonging to the suborder Strongylida."} -{"_id": 2777, "text": "A chordoma that is located_in the skull base."} -{"_id": 2780, "text": "A bovine respiratory disease complex which is an infectious disease in calves involving stress and possibly an initial respiratory viral infection followed by a secondary bacterial infection of the lower respiratory tract. Mycoplasmal and bacterial agents including Pasteurella multocida, Mannheimia haemolytica, and Mycoplasma bovis represent the most frequently isolated pathogenic organisms."} -{"_id": 2783, "text": "A subcutaneous mycosis that involves fungal infection of the subcutaneous tissue caused by members of the order Entomophthorales."} -{"_id": 2786, "text": "A hypersensitivity reaction type I disease located in the respiratory tract."} -{"_id": 2789, "text": "A leukemia that is in between acute and chronic leukemia and is characterized by a moderate duration or severity."} -{"_id": 2792, "text": "A parasitic helminthiasis infectious disease that involves infection by parasitic roundworms including ascarids, filarids, hookworms, pinworms, and whipworms."} -{"_id": 2795, "text": "A viral infectious disease that results_in infection in cattle and swine, has_material_basis_in Foot-and-mouth disease virus, which is transmitted_by contaminated fomites, or transmitted_by ingestion of food contaminated with infected meat or animal products. The infection results_in_formation_of vesicles in the mouth, or on the feet and has_symptom lameness."} -{"_id": 2798, "text": "A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries."} -{"_id": 2801, "text": "A monogenic disease that has_material_basis_in muations on the Y chromosome."} -{"_id": 2804, "text": "A type of ALS caused_by mutation located_in UBQLN 2 gene located_in X chromosome."} -{"_id": 2807, "text": "A fibrosarcoma that is located_in the dermis laryer of the skin and that begins as a hard nodule and grows slowly."} -{"_id": 2810, "text": "A viral infectious disease that results_in infection in horses, mules, donkeys and zebras located_in lung, has_material_basis_in African horsesickness virus, which is transmitted_by biting midge, Culicoides imicola, transmitted_by Culex mosquito, transmitted_by Anopheles mosquito, transmitted_by Aedes mosquito, transmitted_by Hyalomma tick, and transmitted_by Rhipicephalus tick. The infection has_symptom tachypnea, has_symptom forced expiration, has_symptom profuse sweating, has_symptom spasmodic coughing, and has_symptom ecchymoses on the tongue."} -{"_id": 2813, "text": "A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa."} -{"_id": 2816, "text": "A filarial elephantiasis that involves parasitic infection by the nematode Brugia malayi, which inhabits the lymphatics. The symptoms include fever, lymphadenitis, lymphangitis, lymphedema, and secondary bacterial infection."} -{"_id": 2819, "text": "A coxsackie carditis that results_in inflammation located_in pericardium, has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom acute chest pain, has_symptom disturbance of heart rate, and has_symptom dyspnea."} -{"_id": 2822, "text": "A leukemia that is located_in myeloid tissue."} -{"_id": 2825, "text": "A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone."} -{"_id": 2828, "text": "An ampulla of Vater carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 2831, "text": "A dsDNA virus infectious disease that results_in infection in pigs, has_material_basis_in Asfarviridae viruses, which are transmitted_by soft tick bite."} -{"_id": 2834, "text": "A Joubert syndrome subtype with orofaciodigital defect."} -{"_id": 2837, "text": "A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates."} -{"_id": 2840, "text": "A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot."} -{"_id": 2843, "text": "A disease that involving errors in metabolic processes of building or degradation of molecules."} -{"_id": 2846, "text": "An acute stress disorder that involves neurotic reactions to unusual, severe, or overwhelming military stress."} -{"_id": 2849, "text": "An alveolar soft part sarcoma and vulvar sarcoma that is located_in the vulva."} -{"_id": 2852, "text": "A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast."} -{"_id": 2855, "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Flavivirus, which causes encephalitis or hemorrhagic fever in humans and transmitted_by arthropod vectors or transmitted_by contact with infected animal carcasses."} -{"_id": 2858, "text": "A mansonelliasis that involves parasitic infection by the nematode Mansonella ozzardi, which resides in the subcutaneous tissues causing arthralgias, headaches, fever, pulmonary symptoms, adenopathy, hepatomegaly, and pruritus. Both midges and blackflies transmit the disease."} -{"_id": 2861, "text": "A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all."} -{"_id": 2864, "text": "A viral infectious disease that results_in ulceration located_in intestinal epithelium of cats, which has_material_basis_in Feline panleukopenia virus, transmitted_by contact with an infected cat's bodily fluids, feces, or fleas. The infection has_symptom bloody diarrhea, has_symptom dehydration, has_symptom anemia, and has_symptom vomiting."} -{"_id": 2867, "text": "An agnosia that is a loss of the ability to perceive facial expression, body language and intonation, rendering them unable to non-verbally perceive people's emotions and limiting that aspect of social interaction."} -{"_id": 2870, "text": "A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection."} -{"_id": 2873, "text": "A pulmonary tuberculosis that is characterized by filling of airspaces with fluid, inflammatory exudates (pus, proteins and immunological substances) or cells (malignant cells and red blood cells) in a region of the lung."} -{"_id": 2876, "text": "A food allergy that results in adverse immune reaction to one or more of the proteins in cow's milk and/or the milk of other animals, which are normally harmless to the non-allergic individual."} -{"_id": 2879, "text": "A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity."} -{"_id": 2882, "text": "An opportunistic mycosis that has_material_basis_in Galactomyces geotrichum, results_in systemic infection in immunocompromised people."} -{"_id": 2885, "text": "A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause."} -{"_id": 2888, "text": "A syndrome characterized by mild to moderate short stature due to growth delays after birth, distinctive craniofacial abnormalities, skeletal malformations and genital abnormalities."} -{"_id": 2891, "text": ".A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene."} -{"_id": 2894, "text": "A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia."} -{"_id": 2897, "text": "An organic acidemia that involes a nonfunctional propionyl CoA carboxylase affecting conversion of aminio acids and fats into sugar for energy."} -{"_id": 2900, "text": "An agnosia that involves a severe problem with recalling words or names."} -{"_id": 2903, "text": "An actinomycosis that results_in infection located_in skin, has_material_basis_in Actinomyces israelii, which invades the soft tissue resulting in the formation of abnormal channels leading to the skin surface (external sinus tracts) that discharge pale yellow sulfur granules."} -{"_id": 2906, "text": "An adult sarcoma of soft tissue and synovial sarcoma that affects non-epithelial, extraskeletal tissue of the body, including the muscle, fat, fibrous tissue, vessels and peripheral nervous system."} -{"_id": 2909, "text": "An anomalous configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system."} -{"_id": 2912, "text": "A urinary system disease that is located_in the ureter."} -{"_id": 2915, "text": "A cervical carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 2918, "text": "A glioblastoma multiforme that is characterized by the expression of several gene types that are also typical of the brain's normal, noncancerous nerve cells, or neurons."} -{"_id": 2921, "text": "An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection."} -{"_id": 2924, "text": "A respiratory system cancer that is located_in the nasal cavity."} -{"_id": 2927, "text": "A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis."} -{"_id": 2930, "text": "A leprosy that results in one erythematous large plaque with well-defined borders that are elevated and that slope down into an atrophic center."} -{"_id": 2933, "text": "A otitis media which is an expansile, inflammatory mass of granulation tissue in the middle ear. It is a foreign body reaction to cholesterol deposits that occur in obstructed fluid-filled air cells of the temporal bone. It is present with a conductive hearing loss and a blue eardrum."} -{"_id": 2936, "text": "A hereditary spastic paraplegia that is characterized by spasticity of the leg muscles, progressive muscle weakness, paraplegia, muscle wasting in the hands and feet (distal amyotrophy), small stature, developmental delay, learning disorders, speech difficulties (dysarthria), and mood swings, and has_material_basis_in a mutation of the SPG20 gene."} -{"_id": 2939, "text": "A viral infectious disease that results_in infection in humans, has_material_basis_in Mumps virus, which is transmitted_by contact with the oronasal secretions of an infected person."} -{"_id": 2942, "text": "A macular degeneration that can cause progressive vision loss, it is characterized by the disruption of cells in a small area near the center of the retina, the macula."} -{"_id": 2945, "text": "An acromesomelic dysplasia that has_material_basis_in mutation in NPR-B receptor which results_in severe dwarfism, abnormalities of the located_in vertebral column and shortening of middle and distal segments in the located_in limb."} -{"_id": 2948, "text": "A viral infectious disease that involves fever and bleeding disorder caused by Arenavirus."} -{"_id": 2951, "text": "A genetic disease that has_material_basis_in mutations in the MODY genes disrupting insulin production."} -{"_id": 2954, "text": "A hypersensitivity reaction type II disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin)."} -{"_id": 2957, "text": "An autosomal dominant disease that is characterized by ankylosis of the proximal interphalangeal joints, carpal and tarsal bone fusion, and conductive deafness."} -{"_id": 2960, "text": "An autosomal dominant disease characterized by myxomas, spotty pigmentation of the skin and endocrine overactivity."} -{"_id": 2963, "text": "A focal dystonia that affects a single muscle or small group of muscles in the hand resulting from involuntary muscular contractions."} -{"_id": 2966, "text": "A giant cell tumor and bone cancer and bone tissue neoplasm that results_in the presence of multinucleated giant cells (osteoclast-like cell)."} -{"_id": 2969, "text": "An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem."} -{"_id": 2972, "text": "An autosomal dominant cerebellar ataxia that is characterized by slow degeneration of the hindbrain and has_material_basis_in expansion of CAG triplet repeats (glutamine) in the ATXN3 gene."} -{"_id": 2975, "text": "A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching."} -{"_id": 2978, "text": "Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions."} -{"_id": 2981, "text": "A laryngitis which lasts less than a few days."} -{"_id": 2984, "text": "A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon."} -{"_id": 2987, "text": "A pathologic nystagmus, present at birth, characterized by involuntary, rhythmic eye movements; oscillations are usually horizontal in direction."} -{"_id": 2990, "text": "A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. Peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. The symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output."} -{"_id": 2993, "text": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."} -{"_id": 2996, "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in vagina, has_material_basis_in human papillomavirus (type16), which cause malignant tumors in squamous epithelium of the vagina."} -{"_id": 2999, "text": "A sensory organ benign neoplasm that is located in the eye conjunctiva."} -{"_id": 3002, "text": "A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues."} -{"_id": 3005, "text": "A lipoma that is a painful subcutaneous nodule, having all other features of a typical lipoma."} -{"_id": 3008, "text": "A uterine disease that is located_in the placenta."} -{"_id": 3011, "text": "A ptosis characterized by eyelid drop present at birth."} -{"_id": 3014, "text": "A vitamin metabolic disorder that results from low blood levels of vitamin B12."} -{"_id": 3017, "text": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles."} -{"_id": 3020, "text": "A lipid metabolism disorder that has_material_basis_in X-linked inheritance of the tafazzin gene and is characterized by decreased production of an enzyme required to produce cardiolipin."} -{"_id": 3023, "text": "A hyperostosis that involves formation of new bone on the surface of preexisting bone."} -{"_id": 3026, "text": "An osteochondrosis that results_in death and collapse located_in navicular bone of foot."} -{"_id": 3029, "text": "An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress."} -{"_id": 3032, "text": "A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy."} -{"_id": 3035, "text": "A tinea capitis that results_in fungal infection located_in hair, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which produce arthroconidia within the hair shaft only."} -{"_id": 3038, "text": "A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy."} -{"_id": 3041, "text": "An upper respiratory tract disease which involves inflammation of the epiglottis due to infection. Haemophilus influenzae type B is the most common bacterial causative agent, although some cases are attributable to Streptococcus pneumoniae or Streptococcus pyogenes. The infection can cause the epiglottis to either obstruct or completely close off the windpipe. Epiglottitis typically affects children, and is associated with fever, difficulty in swallowing, drooling, hoarseness of voice, and stridor."} -{"_id": 3044, "text": "A neurodegenerative disease that is characterized by progressive cerebellar ataxia, leading to clumsiness in body movements, veering from midline when walking, wide-based stance, and falls without signs of paralysis or weakness and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in degeneration of neuron in the cerebellum, pons and inferior olives."} -{"_id": 3047, "text": "A viral infectious disease that results_in infection, has_material_basis_in Lujo virus, which has_symptom bleeding."} -{"_id": 3050, "text": "An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities."} -{"_id": 3053, "text": "A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year."} -{"_id": 3056, "text": "A syndrome characterized by intellectual disability, specific facial gestalt and Hirschsprung's disease (HSCR). It is caused by homozygous mutation in the KIAA1279 gene on chromosome 10q21.1."} -{"_id": 3059, "text": "A congenital hemolytic anemia characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood."} -{"_id": 3062, "text": "An age related macular degeneration that is characterized by progressive vision loss usually to the point of legal blindness."} -{"_id": 3065, "text": "An adenocarcinoma that results in a hard structure owing to the formation of dense connective tissue in the stroma."} -{"_id": 3068, "text": "An angiosarcoma and sarcoma of prostate that is located_in the prostate."} -{"_id": 3071, "text": "A muscular dystrophy that has_material_basis_in X-linked disease caused by mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy."} -{"_id": 3074, "text": "A papillary adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures with psammoma bodies."} -{"_id": 3077, "text": "A combined T cell and B cell immunodeficiency that is a rare autosomal recessive metabolic disorder caused by a mutaion in the PNP gene and characterized mainly by decreased T-cell function."} -{"_id": 3080, "text": "A viral infectious disease that results_in infection located_in mouth, has_material_basis_in human papillomavirus (types 13 or 32), has_symptom papules or nodules in the oral cavity."} -{"_id": 3083, "text": "A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture."} -{"_id": 3086, "text": "A heavy chain disease that results from an overproduction of mu antibody (IgM)."} -{"_id": 3089, "text": "An organ system cancer located_in the nervous sytem that affects the central or peripheral nervous system."} -{"_id": 3092, "text": "A spinal muscular dystrophy that has_material_basis_in an X-linked recessive expansion of CAG triplet repeats (glutamine)\\nin exon 1 of AR gene encoding the androgen receptor."} -{"_id": 3095, "text": "A Polyomaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Polyomavirus, which cause respiratory symptoms, cystitis or skin cancer."} -{"_id": 3098, "text": "A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary and testis."} -{"_id": 3101, "text": "A primary systemic mycosis that results_in systemic fungal infection through hematogenous spread, has_material_basis_in Sporothrix schenckii, a dimorphic fungus."} -{"_id": 3104, "text": "A hypersensitivity reaction type II disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva."} -{"_id": 3107, "text": "A uterine benign neoplasm derived from the smooth muscle layer of the uterus."} -{"_id": 3110, "text": "A tricuspid valve disease that is a congenital heart defect in which the septal leaflet of the tricuspid valve is displaced towards the apex of the right ventricle of the heart."} -{"_id": 3113, "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth."} -{"_id": 3116, "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood."} -{"_id": 3119, "text": "A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid \\cap\\\" cells of the arachnoid villi in the meninges.\""} -{"_id": 3122, "text": "An impulse control disorder that involves the uncontrollable plucking of ones hair."} -{"_id": 3125, "text": "An intestinal infectious disease that involves infection of the intestine by nosocomial bacterium Enterobacter aerogenes, which results in formation of ulcers."} -{"_id": 3128, "text": "A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages."} -{"_id": 3131, "text": "An eye and adnexa disease that is located in the vitreous of the eye."} -{"_id": 3134, "text": "An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood."} -{"_id": 3137, "text": "A movement disease characterized by brief, semi-directed, irregular movements that not repetitive or rhythmic, but appear to flow from one muscle to the next."} -{"_id": 3140, "text": "A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen."} -{"_id": 3143, "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract."} -{"_id": 3146, "text": "An agnosia that is a loss of the ability to acknowledge objects in the neglected field that are visible when a mirror reflects the object visible in the non-neglected field."} -{"_id": 3149, "text": "A kyphosis that results_in abnormal formation located_in body of vertebra."} -{"_id": 3152, "text": "A labyrinthitits in which bacterial toxins invade the inner ear. It is the most common complication of acute or chronic middle ear infections."} -{"_id": 3155, "text": "A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy."} -{"_id": 3158, "text": "A metal metabolism disorder characterized by the accumulation of iron in various organs of the body."} -{"_id": 3161, "text": "A Cytomegalovirus infectious disease that results_in inflammation, located_in brain, has_material_basis_in Human herpesvirus 5, has_symptom confusional syndrome, has_symptom seizures, has_symptom coma, has_symptom dysphasia, and has_symptom cranial nerve palsies."} -{"_id": 3164, "text": "A parotid disease characterized by the inflammation of one or both parotid glands."} -{"_id": 3167, "text": "A bone marrow cancer that affects plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body."} -{"_id": 3170, "text": "A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs."} -{"_id": 3173, "text": "A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure."} -{"_id": 3176, "text": "A sensory system disease that is located_in the eye or the adnexa of the eye."} -{"_id": 3179, "text": "A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip."} -{"_id": 3182, "text": "An organ system benign neoplasm located_in the axilla, an area directly under the arm and shoulder joint composed_of adipose tissue."} -{"_id": 3185, "text": "A sinusitis which involves infection of the frontal sinuses over the eyes in the brow area. This causes pain or pressure in the frontal sinus cavity and headache over the forehead."} -{"_id": 3188, "text": "A carcinoma of bladder that originates in the epithelial cells (the internal lining) of the bladder wall and is limited to this area."} -{"_id": 3191, "text": "An autosomal recessive disease characterized by oculocutaneous albinism, immune deficiency, coagulation deficiency and neuropathy; it is caused by mutations in the CHS1 gene."} -{"_id": 3194, "text": "A syndrome characterized by the presence of multiple enchondromas (benign growths of cartilage) associated with multiple hemangiomas."} -{"_id": 3197, "text": "A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work."} -{"_id": 3200, "text": "A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles."} -{"_id": 3203, "text": "A disease that has_material_basis_in genetic variations in the human genome."} -{"_id": 3206, "text": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."} -{"_id": 3209, "text": "An inflammatory bowel disease characterized by inflammation located_in ileum, has_symptom diarrhea, has_symptom abdominal pain, often in the right lower quadrant, has_symptom weight loss."} -{"_id": 3212, "text": "A malaria that is caused by the protozoan parasite Plasmodium vivax, which induces paroxysms at 48-hour intervals."} -{"_id": 3215, "text": "An adenovirus infectious disease that involves damage of the cells in the lining of the stomach and intestines caused by adenoviruses (types 40 and 41). The symptoms include watery diarrhea, vomiting and fever."} -{"_id": 3218, "text": "A retinoblastoma that has spread from the soft tissues surrounding the eye or to the optic nerve beyond the margin of resection to other parts of the body."} -{"_id": 3221, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Banna virus, which is transmitted_by Culex, and transmitted_by Anopheles mosquitoes. The infection has_symptom fever, and has_symptom headache."} -{"_id": 3224, "text": "An oropharyngeal candidiasis that involves fungal infection of the oropharynx by Candida species in AIDS patients."} -{"_id": 3227, "text": "A blood platelet disease characterized by low a platelet count in the blood."} -{"_id": 3230, "text": "A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces."} -{"_id": 3233, "text": "A cell type benign neoplasm that is composed_of glandular and fibrous tissues, with a relatively large proportion of glands."} -{"_id": 3236, "text": "A food allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms."} -{"_id": 3239, "text": "A pseudomembranous conjunctivitis characterized by swollen and reddened, hot and painful lids. The Corynebacterium diphtheriae bacilli produce profuse exudation which has a tendency to coagulate on the surface of the conjunctiva to form a grayish-white membrane."} -{"_id": 3242, "text": "A pneumonia that is an acute inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. It is a sentinel health event (occupational) associated with exposure to ammonia (refrigeration, fertilizer, and oil refining industries), chlorine (alkali and bleach industries), nitrogen oxides (silo fillers, arc welders, and nitric acid industry), sulfur dioxide (paper, refrigeration, and oil refining industries), cadmium (processors and cadmium smelters), trimellitic anhydride (plastics and organic chemical synthesis), and vanadium pentoxide (boilermakers). The two types of pulmonary agents are central and peripheral. Central pulmonary agents, for example, ammonia, are water soluble irritants that injure the upper airways. Peripheral pulmonary agents, for example, phosgene, NOx, and PFIB, are slightly water soluble irritants that injure the alveolar-capillary membranes. Chlorine has both central and peripheral effects."} -{"_id": 3245, "text": "An Escherichia coli intestinal infectious disease that involves infection of the intestine caused by a serological subgroup of Escherichia coli called enteroinvasive Escherichia coli (EIEC), which penetrate and multiply within epithelial cells of the colon causing cell destruction. They do not produce toxins but they possess a specific adhesin, which is an outer membrane protein. The symptoms include dysentery-like diarrhea with fever."} -{"_id": 3248, "text": "An aspergillosis that involves fungal infection of the central nervous system in immunocompromised patients caused by Aspergillus, presenting as a space-occupying lesion."} -{"_id": 3251, "text": "An aplastic anemia where the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes)."} -{"_id": 3254, "text": "A syndrome that is an adverse physical reaction to low levels of many common chemicals."} -{"_id": 3257, "text": "A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy."} -{"_id": 3260, "text": "A substance abuse that involves the recurring use of antidepressant drugs despite negative consequences."} -{"_id": 3263, "text": "A parasitic infectious disease that involves parasitic infection by the members of the class Ichthyosporea, which are parasites of fish and other animals."} -{"_id": 3266, "text": "A larynx sarcoma that is a smooth muscle connective tissue tymor located_in the larynx."} -{"_id": 3269, "text": "A retinal disease characterized by the slower than usual adaptation of the eyes to changing light conditions; can be caused by mutations in the RGS9 or the R9AP genes."} -{"_id": 3272, "text": "A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis."} -{"_id": 3275, "text": "An acrofacial dysostosis characterized by a spectrum of mandibulofacial dysostosis phenotypes, such as cleft palate, micrognathia, malar flattening, microcephaly and, in some cases, extrafacial skeletal defects. It is caused by heterozygous mutation in the POLR1A gene located in chromosome 2p11."} -{"_id": 3278, "text": "A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid."} -{"_id": 3281, "text": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions."} -{"_id": 3284, "text": "A crustacean allergy triggered by Scylla paramamosain."} -{"_id": 3287, "text": "A milk allergy triggered by Capra hircus milk."} -{"_id": 3290, "text": "A Mumps virus infectious disease that results_in inflammation located_in peripheral nerves, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom pins-and-needles sensation, has_symptom weakness, and has_symptom numbness."} -{"_id": 3293, "text": "A Simplexvirus infectious disease that results_in inflammation located_in iris and located_in ciliary body of the eye, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, and has_symptom redness, has_symptom photophobia, has_symptom lacrimation, and has_symptom blurred vision."} -{"_id": 3296, "text": "A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night."} -{"_id": 3299, "text": "A disease of mental health that involves disruption of sleep patterns."} -{"_id": 3302, "text": "A severe combined immunodeficiency an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3gamma chain precursors. Patients with CD3gamma deficiency have a severe defect in the expression of the T-cell receptor CD3-complex. Affected patients have decreased T-cell numbers and function; B cells are variably affected."} -{"_id": 3305, "text": "A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia ) or myeloid cells (acute myelocytic leukemia ) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia."} -{"_id": 3308, "text": "An organ system cancer located_in the genitourinary system that is characterized by uncontrolled cellular proliferation in reproductive and urinary organs."} -{"_id": 3311, "text": "An autoimmune disease of skin and connective tissue characterized by large blisters."} -{"_id": 3314, "text": "A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision."} -{"_id": 3317, "text": "A nonparalytic poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, which is transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms."} -{"_id": 3320, "text": "A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel."} -{"_id": 3323, "text": "A scoliosis with no known cause."} -{"_id": 3326, "text": "An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland."} -{"_id": 3329, "text": "A mixed germ cell cancer that is located_in areas of the body other than the ovary or testicle."} -{"_id": 3332, "text": "An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis."} -{"_id": 3335, "text": "A physical disorder characterized by a defect in the development of the abdominal wall muscles, resulting in the intestines, liver and other organs to remain outside of the abdomen in a sac."} -{"_id": 3338, "text": "An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism."} -{"_id": 3341, "text": "A chondrosarcoma that is located_in bone."} -{"_id": 3344, "text": "A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities."} -{"_id": 3347, "text": "A brain cancer that is usually located in the brain, but can occur anywhere in the central nervous system."} -{"_id": 3350, "text": "A syndrome characterized by a unique combination of cardiac arrhythmias and intestinal pseudo-obstruction; caused by the mutated SGOL1 protein. Distinctive clinical features include atrial dysrhythmias, sick sinus syndrome (SSS) and valve anomalies and chronic intestinal pseudo-obstruction (CIPO)."} -{"_id": 3353, "text": "A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached."} -{"_id": 3356, "text": "A syndrome characterized by limb defects, usually bilateral, like cleft hands or feet and longitudinal defects involving radius or ulna, tibia or fibula and renal anomalies which include agenesis, hypoplasia and rarely polycystic kidneys. Additional malformations may involve the oro-mandibular region, the trachea and lungs, skin derivatives including sweat glands, mammary glands, the uterus, vas deferens, the nasal placodes and the eyes."} -{"_id": 3359, "text": "A kidney cancer that is found in the kidney and is usually found before birth by ultrasound or within the first 3 months of life."} -{"_id": 3362, "text": "A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page."} -{"_id": 3365, "text": "A respiratory syncytial virus infectious disease that results_in inflammation located_in lung, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The disease is characterized by occasional multinucleated syncytial giant cells, hyperplasia of alveolar epithelial cells, epithelial necrosis of bronchioles and bronchi, papillary epithelial hyperplasia, and an inflammatory infiltrate composed of lymphocytes and macrophages in the peribronchial space and interstitium."} -{"_id": 3368, "text": "A toxoplasmosis that involves a reactivated infection of the mother transmitted to the fetus during pregnancy. Spontaneous abortion and stillbirth may occur."} -{"_id": 3371, "text": "A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability."} -{"_id": 3374, "text": "A lymphedema commonly located_in legs, caused_by congenital abnormalities in the lymphatic system."} -{"_id": 3377, "text": "A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from spindle cells and/or derives_from giant cells."} -{"_id": 3380, "text": "A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes."} -{"_id": 3383, "text": "A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains."} -{"_id": 3386, "text": "An agnosia that is a loss of the ability to recognize text."} -{"_id": 3389, "text": "A type of ALS with juvenile onset caused_by mutation located_in MATR3 gene located_in chromosome 5."} -{"_id": 3392, "text": "A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body."} -{"_id": 3395, "text": "An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting."} -{"_id": 3398, "text": "A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and results_in_formation_of nodules."} -{"_id": 3401, "text": "A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy."} -{"_id": 3404, "text": "An opportunistic mycosis that results_in disseminated infection, has_material_basis_in Trichosporon and results_in_formation_of nontender erythematous nodules anywhere on the body."} -{"_id": 3407, "text": "A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood."} -{"_id": 3410, "text": "A pigmentation disease characterized by a reticulate pattern of abnormally dark skin coloring, particularly in the body's folds and creases."} -{"_id": 3413, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia."} -{"_id": 3416, "text": "A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium."} -{"_id": 3419, "text": "A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus."} -{"_id": 3422, "text": "A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause."} -{"_id": 3425, "text": "A suppurative otitis media which is an inflammatory disease of the middle ear cleft characterized by the presence of a persisting perforation within the pars tensa of the tympanic membrane, intermittent profuse muco-purulent otorrhea and gradually progressive conductive hearing loss of more than 12 weeks duration. It is caused by episodes of upper respiratory infections."} -{"_id": 3428, "text": "An ectothrix infectious disease that results_in zoophilic inflammatory fungal infection located_in skin, located_in beard, located_in scalp and located_in nail in cattle and humans, has-agent Trichophyton verrucosum."} -{"_id": 3431, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Influenza A virus or has_material_basis_in Influenza B virus, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. The infection has_symptom fever, has_symptom reduced consciousness, and has_symptom ocular muscle palsies."} -{"_id": 3434, "text": "A peripheral neuropathy characterized by congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages."} -{"_id": 3437, "text": "A cancer that affects an anatomical entity."} -{"_id": 3440, "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Picornaviridae viruses."} -{"_id": 3443, "text": "A vascular disease that is located_in an artery."} -{"_id": 3446, "text": "An acute porphyria characterized by painful, blistering skin lesions that develop on sun-exposed skin."} -{"_id": 3449, "text": "A dysgerminoma of ovary that occurs in children."} -{"_id": 3452, "text": "A viral infectious disease that results_in infection located_in skin and located_in mucous membrane of cattle, has_material_basis_in Lumpy skin disease virus, which results_in_formation_of nodules on the skin particularly on the head, neck, udder, genitalia, perineum and legs, has_symptom fever, and has_symptom lymphadenopathy."} -{"_id": 3455, "text": "A Cytomegalovirus infectious disease that results_in infection located_in esophagus, has_material_basis_in Human herpesvirus 5 and has_symptom odynophagia, has_symptom nausea and vomiting, has_symptom fever, has_symptom diarrhea, and has_symptom hemoptysis."} -{"_id": 3458, "text": "A commensal bacterial infectious disease involving Klebsiella pneumoniae infection. Patients with Klebsiella pneumonia tend to cough up a characteristic sputum that is said to resemble \\red-currant jelly\\\". Klebsiella pneumonia tends to affect people with underlying diseases, such as alcoholism, diabetes and chronic lung disease. The symptoms include high fever, rigors and pleuritic pain, and hemoptysis.\""} -{"_id": 3461, "text": "A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus Leishmania, which is transmitted by the bite of sand fly (subfamily Phlebotominae)."} -{"_id": 3464, "text": "A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information."} -{"_id": 3467, "text": "A malaria that involves infection with more than one species of Plasmodium at the same time."} -{"_id": 3470, "text": "An eye disease where one or both eyeballs are abnormally small."} -{"_id": 3473, "text": "An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells."} -{"_id": 3476, "text": "A lysosomal storage disease that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase)."} -{"_id": 3479, "text": "A retinal vascular disease characterized by the prevention of blood vessel formation at the edges of the retina and the hemorrhage of the blood vessels in the retina."} -{"_id": 3482, "text": "A soft tissue cancer that is a soft tissue sarcoma and originates in the pericytes in the walls of capillaries."} -{"_id": 3485, "text": "A staphylococcal infectious disease that is caused by ingestion of food containing enterotoxins, which are produced by staphylococcal species. The symptoms include abdominal cramps, diarrhea, headache and fever."} -{"_id": 3488, "text": "An X-linked disease that is characterized by intellectual disability, truncal obesity, seizures, hypogonadism, developmental delay, distinctive facial features, tapered fingers and short toes and has_material_basis_in X-linked recessive inheritance of mutations in the PHF6 gene."} -{"_id": 3491, "text": "A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right)."} -{"_id": 3494, "text": "A tertiary syphilis that is characterized by granulomatous lesions, called gummas, which are characterized by a center of necrotic tissue with a rubbery texture. They form in the liver, bones, and testes but may affect any organ."} -{"_id": 3497, "text": "A late yaws that involves destruction of the bone and cartilage of the nose. This is caused by the spirochete bacterium, Treponema pallidum pertenue."} -{"_id": 3500, "text": "A viral infectious disease that results_in infection, has_material_basis_in Dengue virus with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding."} -{"_id": 3503, "text": "A cognitive disorder that involves an excessive, irrational dread of everyday situations."} -{"_id": 3506, "text": "A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening."} -{"_id": 3509, "text": "A viral infectious disease that results_in infection in cattle and other ruminants, has_material_basis_in Macavirus and has_symptom fever, has_symptom bilateral corneal opacity, and has_symptom oculonasal discharge."} -{"_id": 3512, "text": "An opportunistic mycosis that results_in fungal infection located_in lungs, has_material_basis_in Mucorales molds and has_symptom hemoptysis and has_symptom necrosis."} -{"_id": 3515, "text": "A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder."} -{"_id": 3518, "text": "A histiocytic and dendritic cell cancer that effect dendritic cells."} -{"_id": 3521, "text": "A staphylococcal infectious disease that is caused due to the infection by Gram-positive bacterium Staphylococcus aureus, which is an important cause of hospital-acquired infection that results in the formation of abscesses, empyema, pneumothorax, and cyst."} -{"_id": 3524, "text": "A carcinoma that is in situ (very early-stage breast cancer)."} -{"_id": 3527, "text": "A coxsackie carditis that results_in inflammation located_in myocardium, has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom lethargy, has_symptom heart failure, has_symptom pallor, has_symptom cyanosis, has_symptom dyspnea, has_symptom tachycardia, and has_symptom enlargement of heart."} -{"_id": 3530, "text": "A bacterial infectious disease that results_in infection by bacteria in individuals whose host defense mechanisms have been compromised."} -{"_id": 3533, "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system."} -{"_id": 3536, "text": "A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma."} -{"_id": 3539, "text": "A meningioma by site and orbital neoplasm that is located_in the area around the eye sockets of the skull and results_in pressure in the eyes, giving a bulging appearance."} -{"_id": 3542, "text": "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss."} -{"_id": 3545, "text": "An inherited blood coagulation disease characterized by the tendency to form clots in the veins."} -{"_id": 3548, "text": "An oral cavity cancer that has_material_basis_in squamous cells."} -{"_id": 3551, "text": "An opportunistic mycosis that results_in fungal infection located_in human body, has_material_basis_in Microsporidia phylum members."} -{"_id": 3554, "text": "A syndrome affecting returning military veterans and civilian workers of the Gulf War."} -{"_id": 3557, "text": "A hypersensitivity reaction type II disease that involves inflammation or pain in the muscles, joints, or fibrous tissue."} -{"_id": 3560, "text": "An amino acid metabolic disorder that has_material_basis in deficiency of ornithine translocase resulting in the accumulation of ammonia in the blood."} -{"_id": 3563, "text": "An Escherichia coli intestinal infectious disease that involves infection of the intestine caused by a serological subgroup of Escherichia coli called enterohemorrhagic Escherichia coli (EHEC), which cause hemorrhagic colitis or bloody diarrhea that can progress to hemolytic uremic syndrome. EHEC are considered to be moderately invasive and are characterized by the production of verotoxin or Shiga toxins. The infection results in copious bloody discharge."} -{"_id": 3566, "text": "A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss."} -{"_id": 3569, "text": "An exostosis that results_in an abnormal growth located_in calcaneus."} -{"_id": 3572, "text": "A respiratory syncytial virus infectious disease that results_in inflammation located_in bronchiole, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. Infection is characterized by inflammation, edema, and necrosis of the small airway epithelium with associated bronchospasm and increased mucous production."} -{"_id": 3575, "text": "A carcinoma that derives_from neuroendocrine cells."} -{"_id": 3578, "text": "An autosomal recessive disease that is caused by rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging."} -{"_id": 3581, "text": "A gastrointestinal system cancer that has_material_basis_in neuroendocrine cells."} -{"_id": 3584, "text": "An aortic aneurysm that is located_in the thoracic aorta."} -{"_id": 3587, "text": "An osteochondrodysplasia characterized by short limbs and a short trunk with a barrel-shaped chest and caused_by homozygous or compound heterozygous mutation in the DYM gene on chromosome 18q."} -{"_id": 3590, "text": "An anal carcinoma that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the anal margin (where the canal meets the outside skin at the anus)."} -{"_id": 3593, "text": "A transitional cell carcinoma that has several papillary fronds with central fibrovascular core lined by transitional type epithelium."} -{"_id": 3596, "text": "A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by viruses. The symptoms include abdominal pain, indigestion, ulcer formation, abdominal bloating, nausea and vomiting."} -{"_id": 3599, "text": "An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism."} -{"_id": 3602, "text": "A monogenic disease that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth)."} -{"_id": 3605, "text": "A colorectal cancer that is located_in the colon."} -{"_id": 3608, "text": "A pulmonary tuberculosis presenting as multiple bilateral large nodules in the lungs."} -{"_id": 3611, "text": "A RNA virus infectious disease that results_in infection, has_material_basis_in ssRNA retro-transcribing viruses, which possess single-stranded RNA genomes and replicate using reverse transcriptase."} -{"_id": 3614, "text": "A Mumps virus infectious disease that results_in inflammation located_in testis, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom groin pain, has_symptom discharge from penis, has_symptom scrotal swelling, and has_symptom blood in the semen."} -{"_id": 3617, "text": "An Alveolata infectious disease that involves infection caused by the members of the phylum Apicomplexa, which are unicellular, spore forming parasites of animals and humans."} -{"_id": 3620, "text": "A gastrointestinal system disease that is located_in the mouth."} -{"_id": 3623, "text": "A vitamin B12 deficiency that is characterized by megaloblastic anemia due to the absence of gastric intrinsic factor which results in abnormal vitamin B12 absorption."} -{"_id": 3626, "text": "A syndrome characterized by facial abnormalities such as telecanthus, epicanthus, broad flattened nose, large inverted W-shaped mouth and malformed ears, malformed extremities such as camptodactyly, clinodactyly, interdigital webbing and joint hyperlaxity and mental retardation."} -{"_id": 3629, "text": "A neonatal period electroclinical syndrome that is characterized by tonic-clonic seizures in newborns occurring within the first seven days of life and ceasing within the first 15 weeks of life and has_material_basis_in autosomal dominant inheritance of voltage-gated potassium channels or a chromosomal inversion."} -{"_id": 3632, "text": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle."} -{"_id": 3635, "text": "A fish allergy triggered by Cyprinus carpio."} -{"_id": 3638, "text": "A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow."} -{"_id": 3641, "text": "A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin."} -{"_id": 3644, "text": "An electroclinical syndrome with onset in the neonatal period less than 44 weeks of gestational age."} -{"_id": 3647, "text": "A parotid gland cancer that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ."} -{"_id": 3650, "text": "Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents."} -{"_id": 3653, "text": "A pneumoconiosis caused by inhalation and retention of asbestos fibers."} -{"_id": 3656, "text": "A viral gastritis that involves inflammation of the stomach lining caused by herpes simplex virus."} -{"_id": 3659, "text": "An agnosia that is a loss of the ability to gain feedback about one's own condition or impairments."} -{"_id": 3662, "text": "A syndrome mainly characterized by severe growth retardation and microcephaly. It is a new form of cohesinopathy showing defects in sister chromatid cohesion and hypersensitivity to chemicals that induce replication stress, thus combining distinct cytogenetic features seen in Roberts syndrome and Fanconi anemia, respectively. It is caused by homozygous or compound heterozygous mutation in the DDX11 gene on chromosome 12p11."} -{"_id": 3665, "text": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis."} -{"_id": 3668, "text": "An intestinal disease characterized by a dysbalance of the bacterial flora of the small intestine, causing derangement to the normal physiological processes of digestion and absorption."} -{"_id": 3671, "text": "A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms."} -{"_id": 3674, "text": "A bipolar disorder that is characterized by at least one manic or mixed episode."} -{"_id": 3677, "text": "An opportunistic mycosis that is located_in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has_symptom nonproductive cough, has_symptom shortness of breath, and has_symptom fever."} -{"_id": 3680, "text": "An idiopathic interstitial pneumonia that occurs mainly in women, people who do not smoke, and people younger than 50 years with no known cause or risk factors. Lung biopsies may show predominantly interstitial inflammation or fibrosis or a combination of inflammation and fibrosis. A dry cough and shortness of breath develop over 6 to 18 months. Low-grade fever and a feeling of illness (malaise) may occur."} -{"_id": 3683, "text": "A microsporidiosis that is a zoonotic infectious disease results_in disseminated fungal infection in dogs, cats, hamsters, guinea pigs, rats, mice and humans, has_material_basis_in Encephalitozoon cuniculi, has_material_basis_in Encephalitozoon intestinalis or has_material_basis_in Encephalitozoon hellem."} -{"_id": 3686, "text": "A parasitic helminthiasis infectious disease that involves infection caused by parasitic invertebrates, which have a pseudocoel. Tissue derived from mesoderm only partly lines the fluid filled body cavity of these animals."} -{"_id": 3689, "text": "An adenoma and biliary tract cancer that results_in a small firm white nodule with multiple bile ducts that are located_in a fibrous stroma."} -{"_id": 3692, "text": "A anus cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the anus."} -{"_id": 3695, "text": "A non-small cell lung carcinoma that has_material_basis_in the squamous cell."} -{"_id": 3698, "text": "A myotonic disease that is characterized by myotonia and progressive, proximal muscle wasting and weakness affecting the skeletal and smooth muscles of the neck, shoulders, elbows and hips and has_physical_basis_in the autosomal dominant inheritance of the CNBP (ZNF9) gene containing an expansion of a CCTG repeat in intron one."} -{"_id": 3701, "text": "An extrapulmonary tuberculosis that is located_in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction."} -{"_id": 3704, "text": "An opportunistic mycosis that is located_in lungs caused by inhalation of fungal spores while stripping the bark from maple logs, has_material_basis_in Cryptostroma corticale."} -{"_id": 3707, "text": "A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton mentagrophytes and results_in_formation_of subcutaneous abscesses."} -{"_id": 3710, "text": "An opportunistic mycosis that has_material_basis_in Scopulariopsis, which results_in a systemic infection in immunocompromised individuals."} -{"_id": 3713, "text": "Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection."} -{"_id": 3716, "text": "An appendix cancer that has_material_basis_in neurodendocrine cells."} -{"_id": 3719, "text": "A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella."} -{"_id": 3722, "text": "A parasitic protozoa infectious disease that has_symptommild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease."} -{"_id": 3725, "text": "A neutropenia characterized by a maturation arrest of granulopoiesis at the level or promyelocytes and early onset of severe bacterial infections."} -{"_id": 3728, "text": "A glioblastoma multiforme that is characterized by IDH1 and p53 mutations and Platelet Derived Growth Factor A amplification."} -{"_id": 3731, "text": "An autosomal recessive disease characterized by severe intellectual disability, epilepsy, scoliosis, choreoathetosis, dysmorphic facial features and altered dermal pigmentation."} -{"_id": 3734, "text": "An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system."} -{"_id": 3737, "text": "An amino acid metabolic disorder that involves impaired break down of the amino acid tyrosine."} -{"_id": 3740, "text": "A disease of anatomical entity that occurs in the muscular and/or skeletal system."} -{"_id": 3743, "text": "A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood."} -{"_id": 3746, "text": "A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing."} -{"_id": 3749, "text": "A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage."} -{"_id": 3752, "text": "A bronchus cancer that has_material_basis_in epithelial cells."} -{"_id": 3755, "text": "An autosomal recessive disease that is characterized by brachydactyly, hyperphalangism of digits, facial dysmorphism, dental anomalies, sensorineural hearing loss, delayed motor and mental development, and growth retardation and has_material_basis_in homozygous mutation in the CHSY1 gene."} -{"_id": 3758, "text": "A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels."} -{"_id": 3761, "text": "A vaginal carcinosarcoma derives_from the glands that line the uterus."} -{"_id": 3764, "text": "A metaphyseal dysplasia that results_in short-limbed dwarfism and fine sparse hair."} -{"_id": 3767, "text": "A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin."} -{"_id": 3770, "text": "A laryngitis in which symptoms last longer than three weeks. Gastroesophageal reflux, and lingering bronchitis can cause the disease."} -{"_id": 3773, "text": "An autosomal recessive disease characterized by mulitple fetal developmental defects including polydactyly and central nervous system malformations that results from a single amino acid mutation of D211G of the HYLS1 gene which plays a central role in cilia formation."} -{"_id": 3776, "text": "A fungal infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Fungi, which penetrate the dermis or even deeper during or after a skin trauma."} -{"_id": 3779, "text": "A palmoplantar keratosis characterized by keratoses with a \\raindrop\\\" pattern on the palmoplantar surface, skin lesions which may involve the whole of the palmoplantar surface, or may be more restricted in their distribution.\""} -{"_id": 3782, "text": "A Mononegavirales infectious disease that results_in infection in animals and humans, has_material_basis_in Rhabdoviridae viruses."} -{"_id": 3785, "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body."} -{"_id": 3788, "text": "A respiratory system cancer that is located_in the paranasal sinuses."} -{"_id": 3791, "text": "A placenta disease that is characterized by separation of the placental lining from the uterus of the mother."} -{"_id": 3794, "text": "An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type."} -{"_id": 3797, "text": "A desmoplastic small round-cell tumor that primarily is located_in the abdomen."} -{"_id": 3800, "text": "A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance."} -{"_id": 3803, "text": "A thyroid gland disease that involves an over production of thyroid hormone."} -{"_id": 3806, "text": "An urogenital tuberculosis that is located_in epididymis, has_symptom pain and has_symptom scrotal swelling."} -{"_id": 3809, "text": "A physical disorder characterized by pancreatic fibrosis, renal dysplasia and hepatic dysgenesis; it is usual fatal soon after birth."} -{"_id": 3812, "text": "A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted_by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins."} -{"_id": 3815, "text": "A thymic carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 3818, "text": "A vascular disease that is characterized by inflammation of the blood vessels."} -{"_id": 3821, "text": "An organ system benign neoplasm that is located_in the serous membrane lining the abdominal cavity or coelom."} -{"_id": 3824, "text": "An ophthalmic herpes zoster that results_in inflammation located_in iris and located_in ciliary body, has_material_basis_in Human herpesvirus 3,which reactivates from the trigeminal ganglion after the primary infection and has_symptom photophobia, has_symptom redness, has_symptom lacrimation, and blurres vision."} -{"_id": 3827, "text": "An autosomal dominant disease that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas."} -{"_id": 3830, "text": "An Enterovirus infectious disease that results_in infection, has_material_basis_in Swine vesicular disease virus, which is transmitted_by ingestion of contaminated food, or transmitted_by contact with an infected animal. The infection results_in_formation_of vesicles in the mouth, snout and feet, and has_symptom lameness."} -{"_id": 3833, "text": "A muscular dystrophy that chiefly affects muscles used for movement (skeletal) and heart (cardiac) muscle."} -{"_id": 3836, "text": "A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac."} -{"_id": 3839, "text": "A sarcoma and malignant neoplasm of anus that is located_in the anus."} -{"_id": 3842, "text": "A severe combined immunodeficiency that is an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3epsilon chain precursors. Patients with CD3epsilon deficiency have a severe defect in the expression of the T-cell receptor CD3-complex."} -{"_id": 3845, "text": "An agnosia that is a loss of the ability to recognising spoken words as semantically meaningful."} -{"_id": 3848, "text": "An acquired metabolic disease that is characterized by abnormal mineral metabolism."} -{"_id": 3851, "text": "A mood disorder that involves alternating periods of mania and depression."} -{"_id": 3854, "text": "A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs."} -{"_id": 3857, "text": "A diphtheria that involves membrane formation from the faucial tonsil areas over the pharyngeal wall and into the nasopharynx. Severe disease may cause marked edema of the submandibular areas and the anterior neck along with lymphadenopathy, giving a characteristic \\bullneck\\\" apprearance.\""} -{"_id": 3860, "text": "A acute serous otitis media caused by an allergen."} -{"_id": 3863, "text": "A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis."} -{"_id": 3866, "text": "A viral infectious disease that results_in infection in cattle, dogs, horses, pigs, and humans, has_material_basis_in Adenoviridae viruses."} -{"_id": 3869, "text": "A tricuspid valve disease that is characterized by the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve."} -{"_id": 3872, "text": "A lacrimal gland carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 3875, "text": "A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired."} -{"_id": 3878, "text": "A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair."} -{"_id": 3881, "text": "A carcinoma that derives_from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm."} -{"_id": 3884, "text": "A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough."} -{"_id": 3887, "text": "A squamous cell carcinoma that has papillae, which are characterized either by narrow fibrovascular cores that superficially resemble papillary carcinoma of the urinary tract or by broad cores that contain edematous fibrous stroma with prominent capillaries and stromal inflammation."} -{"_id": 3890, "text": "A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions."} -{"_id": 3893, "text": "A hyperostosis characterized by excessive bone formation most prominent in the skull, mandible, clavicle, ribs and diaphyses of long bones; bone formation occurs throughout life."} -{"_id": 3896, "text": "A syndrome that is characterized by blepharophimosis, ptosis, dental hypoplasia, hearing impairment and intellectual disability."} -{"_id": 3899, "text": "A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath."} -{"_id": 3902, "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain."} -{"_id": 3905, "text": "A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands."} -{"_id": 3908, "text": "A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy."} -{"_id": 3911, "text": "A serine deficiency that has_material_basis_in deficiency of phosphoserine aminotransferase and is characterized by low concentartions of serine and flycine in plasma and cerebrospinal fluid."} -{"_id": 3914, "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme iduronate sulfatase."} -{"_id": 3917, "text": "A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia."} -{"_id": 3920, "text": "A stomach disease that is an inflammation of the lining of the stomach."} -{"_id": 3923, "text": "A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing."} -{"_id": 3926, "text": "An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue."} -{"_id": 3929, "text": "A severe combined immunodeficiency that is an actin regulator when mutated results in SCID through inhibition of thymic egress of mature thymocytes into peripheral lymphoid organs."} -{"_id": 3932, "text": "A viral infectious disease that results_in infection located_in brain, has_material_basis_in Measles virus which is immune resistant (which can be a result of a mutation of the virus itself)."} -{"_id": 3935, "text": "A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage."} -{"_id": 3938, "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, with villous architecture."} -{"_id": 3941, "text": "A lymph node disease characterized by enlarged, non-painful lymph nodes occurring for more than three to six months for which no other reason can be found."} -{"_id": 3944, "text": "An acrocephalosyndactylia characterized by craniosynostosis, acrocephaly, obesity, syndactyly and polydactyly."} -{"_id": 3947, "text": "An opportunistic fungi incertae sedis mycosis that results_in fungal infection located_in sinuses, located_in brain, or located_in lungs of immunocompromised people, has_material_basis_in Mucorales molds."} -{"_id": 3950, "text": "A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language."} -{"_id": 3953, "text": "A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis."} -{"_id": 3956, "text": "A tertiary syphilis that results_in infection located_in brain or located_in spinal cord."} -{"_id": 3959, "text": "A musculoskeletal system cancer that is located_in muscle."} -{"_id": 3962, "text": "A muscular dystrophy that is characterized by progressive muscle wasting and weakness."} -{"_id": 3965, "text": "A uterine corpus cancer that has_material_basis_in more than one type of cell."} -{"_id": 3968, "text": "A pleural cancer that has_material_basis_in mesothelium cells."} -{"_id": 3971, "text": "A uterine cancer that is located_in tissues lining the uterus."} -{"_id": 3974, "text": "An autosomal recessive disease characterized by dwarfism, facial dysmorphia and skeletal abnormalities."} -{"_id": 3977, "text": "A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart."} -{"_id": 3980, "text": "A serine deficiency that has_material_basis_in deficiency of phosphoserine phosphatase impeding the synthesis of L-serine."} -{"_id": 3983, "text": "A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction."} -{"_id": 3986, "text": "A thyroid sarcoma and angiosarcoma that results_in a high prevalence of iodine-deficient goiter."} -{"_id": 3989, "text": "An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body."} -{"_id": 3992, "text": "An autosomal dominant disease that is characterized by the iris stroma being hypoplastic resulting from abnormalities in the differentiation of the anterior segment structures and increased values of intraocular pressure and has_material_basis_in autosomal dominant inheritance of mutations in the PITX2 gene."} -{"_id": 3995, "text": "A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis."} -{"_id": 3998, "text": "A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved."} -{"_id": 4001, "text": "A lung cancer that derives_from the distal bronchioles or alveoli that initially exhibit a specific non-invasive growth pattern."} -{"_id": 4004, "text": "A dystonia that involves two or more unrelated body parts."} -{"_id": 4007, "text": "A otosalpingitis which is persistent and long-lasting."} -{"_id": 4010, "text": "A substance abuse that involves the recurring use of opioid drugs despite negative consequences."} -{"_id": 4013, "text": "A syndrome characterized by intellectual disability and developmental delay, breathing problems, recurrent seizures (epilepsy), and distinctive facial features. It is caused by heterozygous de novo mutations in the TCF4 gene in chromosome 18q21."} -{"_id": 4016, "text": "A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern."} -{"_id": 4019, "text": "A parasitic protozoa infectious disease that involves infection caused by parabasalids, which are anaerobic flagellated protozoans."} -{"_id": 4022, "text": "A selective immunoglobulin deficiency disease that is caused by a reduction in some types of gamma globulins."} -{"_id": 4025, "text": "An intestinal benign neoplasm that has_material_basis_in epithelial tissue with glandular origin and is located_in the rectum."} -{"_id": 4028, "text": "A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption."} -{"_id": 4031, "text": "A malignant neoplasm of ovary and nephroblastoma that is located_in the ovaries."} -{"_id": 4034, "text": "A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components."} -{"_id": 4037, "text": "A bone benign neoplasm that is located_in the phalanx that has_material_basis_in cartilaginous cells."} -{"_id": 4040, "text": "A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids."} -{"_id": 4043, "text": "An adult sarcoma of soft tissue that derives_form the soft tissues of the body."} -{"_id": 4046, "text": "A otosalpingitis with a sudden onset and a short course."} -{"_id": 4049, "text": "A purine-pyrimidine metabolic disorder that is an autosomal recessive metabolic disorder in which there is absent or significantly decreased activity of dihydropyrimidine dehydrogenase, an enzyme involved in the metabolism of uracil and thymine."} -{"_id": 4052, "text": "An agnosia that results in the loss of the ability to consciously recognize familiar faces."} -{"_id": 4055, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa."} -{"_id": 4058, "text": "A somatoform disorder that involves heart disease symptoms without any identifiable physiological abnormatlities."} -{"_id": 4061, "text": "A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness."} -{"_id": 4064, "text": "A dysostosis characterized by intellectual disability, short stature, hypertelorism, broad notched nasal tip, cleft lip palate, postaxial camptobrachypolysyndactyly, fibular hypoplasia and anomalies of foot structure."} -{"_id": 4067, "text": "A Charcot-Marie-Tooth disease characterized by demyelination of the peripheral nerve axons."} -{"_id": 4070, "text": "A biliary tract neoplasm that has_material_basis_in epithelial tissue of glandular origin located_in the gallbladder."} -{"_id": 4073, "text": "A non-syndromic intellectual disability characterized by an autosomal recessive inheritance pattern."} -{"_id": 4076, "text": "A dsRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Reoviridae viruses."} -{"_id": 4079, "text": "A monogenic disease that is characterized by hypertelorism, hypospadias, and additional midline defects resulting from mutations to the MID1 gene in the X-linked form or from a deletion on chromosome 22q11.2 in the autosomal dominant form."} -{"_id": 4082, "text": "A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength."} -{"_id": 4085, "text": "A cryptococcosis that is_a disease associated with AIDS has_material_basis_in Cryptococcus neoformans which results_in a systemic infection in individuals with HIV."} -{"_id": 4088, "text": "A ciliopathy that causes a defect in the action of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube."} -{"_id": 4091, "text": "A nervous system disease that results_from damage located_in left parietal lobe, has_symptom agraphia, has_symptom acalculia, has_symptom finger agnosia."} -{"_id": 4094, "text": "A salivary gland cancer that has_material_basis_in epithelial cells."} -{"_id": 4097, "text": "A taeniasis that results from ingestion of eggs or larvae of the Taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. Neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions."} -{"_id": 4100, "text": "An ophthalmic herpes zoster that results_in inflammation located_in cornea and located_in conjunctiva, has_material_basis_in Human herpesvirus 3, which reactivates from the trigeminal ganglion after the primary infection and has_symptom red eye, has_symptom irritation, and has_symptom pain."} -{"_id": 4103, "text": "A lysosomal storage disease that has_material_basis_in deficiency of the alpha-D-manosidase enzyme resulting in the impairment of cell function from a build up of complex sugars derived from glycoproteins in the lysosome."} -{"_id": 4106, "text": "A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years."} -{"_id": 4109, "text": "A blepharoconjunctivitis that is characterized by fissuring, scaling, maceration and erythema of the lateral or medial canthal area."} -{"_id": 4112, "text": "An aortic valve disease that has_physical_basis_in incomplete opening of the aortic valve."} -{"_id": 4115, "text": "A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids."} -{"_id": 4118, "text": "A spinal cancer that is located_in the spinal cord and derives_from lymphocytes."} -{"_id": 4121, "text": "An adrenal medulla cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 4124, "text": "A nervous system disease that is located_in nerves or nerve cells."} -{"_id": 4127, "text": "An Apicomplexa infectious disease that involves infection caused by the members of the class Aconoidasida."} -{"_id": 4130, "text": "A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles."} -{"_id": 4133, "text": "A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness."} -{"_id": 4136, "text": "An appendix carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 4139, "text": "An organ system benign neoplasm that is located_in reproductive system organs."} -{"_id": 4142, "text": "An osteochondrodysplasia that results_in short arms and legs with excess folds of skin."} -{"_id": 4145, "text": "A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization."} -{"_id": 4148, "text": "A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 4151, "text": "A corneal dystrophy that is characterized by corneal haze, bilateral loss of vision, eventually necessitating corneal transplantation resulting from progressive punctate opacities in the cornea."} -{"_id": 4154, "text": "An Enterovirus infectious disease that results_in infection located_in gastrointestinal tract, or located_in skin, has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by droplet spread of oronasal secretions from infected person, or transmitted_by contaminated fomites."} -{"_id": 4157, "text": "A fallopian tube cancer that is characterized as a mixture of carcinoma and sarcoma and has_material_basis_in epithelial tissue and has_material_basis_in connective tissue."} -{"_id": 4160, "text": "An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently and characterized by an enlarged heart."} -{"_id": 4163, "text": "An osteosclerosis that results_in coarsening located_in trabecular bone."} -{"_id": 4166, "text": "A genetic disease that is characterized by permanently bent fingers (camptodactyly), short stature, rocker-bottom or club feet, joints that are bent in a fixed position (contractures), union or webbing of the skin between the fingers (syndactyly), and/or webbing of the neck, inside bend of the elbows, back of the knees and armpits."} -{"_id": 4169, "text": "A bile duct carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 4172, "text": "A multiple carboxylase deficiency that involves a deficiency in biotinidase."} -{"_id": 4175, "text": "A shellfish allergy triggered by Crustacea."} -{"_id": 4178, "text": "An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function."} -{"_id": 4181, "text": "An embryonal cancer that are masses of rapidly growing cells that originates in embryonic (fetal) tissue in the brain and spinal cord."} -{"_id": 4184, "text": "A syndrome characterized by unusually sparse, brittle, curly hair, macrocephaly, a prominent forehead and bi-temporal narrowing, intellectual disability, failure to thrive, congenital heart defects, short stature and skin abnormalities; it is caused by mutation in the BRAF, MAP2K1, MAP2kK2 and KRAS genes."} -{"_id": 4187, "text": "A viral infectious disease that results_in infection in fish, has_material_basis_in Viral hemorrhagic septicemia virus, which is transmitted_by contact with the contaminated water, or transmitted_by direct contact. The infection has_symptom hemorrhages in the internal organs, skin, and muscle, has_symptom bulging eyes, and has_symptom bloated abdomens."} -{"_id": 4190, "text": "A Varicellovirus infectious disease that results_in infection located_in skin of eyelid, has_material_basis_in Human herpesvirus 3 and has_symptom rash after the reactivation of latent virus years after the primary infection."} -{"_id": 4193, "text": "A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs."} -{"_id": 4196, "text": "A dystonia that affects most or all of the body."} -{"_id": 4199, "text": "A pharynx cancer that has_material_basis_in squamous cells."} -{"_id": 4202, "text": "A mucopolysaccharidosis characterized by corneal clouding, facial dysmorphism and normal lifespan."} -{"_id": 4205, "text": "A Simplexvirus infectious disease that results_in inflammation located_in liver, has-agent Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, and has_symptom fever, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, and has_symptom herpetic lesions."} -{"_id": 4208, "text": "A severe combined immunodeficiency that affects the development and function of T cells."} -{"_id": 4211, "text": "A primary Bacillaceae infectious disease involving Bacillus anthracis infection resulting in pulmonary infiltrates and necrosis."} -{"_id": 4214, "text": "A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign."} -{"_id": 4217, "text": "A syndrome that is characterized by large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues."} -{"_id": 4220, "text": "A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver."} -{"_id": 4223, "text": "A mitochondrial metabolism disease that is characterized by hearing loss that begins early in life, problems with movement, impaired vision, and behavior problems."} -{"_id": 4226, "text": "A type of ALS were intermediate-length polyglutamine repeat expansions in the ATXN2 gene located_in chromosome 12 contribute to susceptibility."} -{"_id": 4229, "text": "A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations."} -{"_id": 4232, "text": "A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies."} -{"_id": 4235, "text": "An osteosclerosis that results_in increased calcium concentration located_in skull which decreases the size of cranium foramina and cervical spinal canal."} -{"_id": 4238, "text": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp."} -{"_id": 4241, "text": "A food allergy triggered by Crustacea or Mollusca."} -{"_id": 4244, "text": "A middle ear carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 4247, "text": "A carbohydrate metabolic disorder that involves a defect in galactose metabolism resulting in toxic levels of galactose 1-phosphate in various tissues."} -{"_id": 4250, "text": "A parasitic infectious disease that involves infection caused by parasitic members of the taxon stramenopiles, in which the flagellate cells possess two different shaped flagella. This taxon contains both unicellular and multicellular organisms."} -{"_id": 4253, "text": "An acquired metabolic disease that has_material_basis_in low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate."} -{"_id": 4256, "text": "A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures."} -{"_id": 4259, "text": "An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by a translocation between chromosomes 15 and 17."} -{"_id": 4262, "text": "A blood platelet disease characterized by thrombocytopathy, thrombocytopenia, mild anemia, asplenia, tubular aggregate myopathy, miosis, headache, and ichthyosis. It is caused by heterozygous in the STM1 gene located in chromosome 11p15. It has an autosomal dominant inheritance pattern."} -{"_id": 4265, "text": "A syndrome characterized by a combination of multiple joint contractures and osteogenesis imperfecta."} -{"_id": 4268, "text": "An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb Dwarfism."} -{"_id": 4271, "text": "A cerebellum cancer that begins in the lower part of the brain on the floor of the skull."} -{"_id": 4274, "text": "An inherited metabolic disorder that involves plasma protein metabolism malfunction."} -{"_id": 4277, "text": "An immune system disease that has_material_basis_in hematopoietic cells."} -{"_id": 4280, "text": "An autosomal recessive disease characterized by severe intellectual disability, microcephaly, congenital cataract, microcornea, microphthalmia, agenesis or hypoplasia of the corpus callosum and hypogenitalism."} -{"_id": 4283, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Dicrocoelium dendriticum. The symptoms include cholecystitis, liver abscesses and upper abdominal pain."} -{"_id": 4286, "text": "A parasitic protozoa infectious disease that involves an infection in humans and animals caused by a parasitic protozoan of genus Acanthamoeba, which is an opportunistic pathogen occuring in patients with weakened immune system."} -{"_id": 4289, "text": "A Yellow fever virus infectious disease that results_in inflammation located_in liver, has_material_basis_in Yellow fever virus. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom weakness, has_symptom nausea, has_symptom vomiting, has_symptom jaundice, and has_symptom hemorrhagic manifestations."} -{"_id": 4292, "text": "A parasitic helminthiasis infectious disease that involves infection of the small intestine in humans, cats, dogs and foxes by the nematode Uncinaria stenocephala. The symptoms include diarrhea and hypoproteinemia in heavier infections."} -{"_id": 4295, "text": "An Apicomplexa infectious disease that involves infection caused by the members of the class Coccidia, which are spore-forming, single-celled and obligate intracellular parasites of the intestinal tract of animals and humans."} -{"_id": 4298, "text": "An amyotrophic lateral sclerosis caused_by mutation located_in TUBA4A gene located_in chromosome 2q35."} -{"_id": 4301, "text": "A non-Hodgkin's lymphoma that is caused by a mutation of T cells."} -{"_id": 4304, "text": "A specific phobia that involves a fear caused by the presence or thought of a specific animal that poses little or no danger at all."} -{"_id": 4307, "text": "A breast carcinoma that is located_in the nipple."} -{"_id": 4310, "text": "An organ system benign neoplasm that is located_in the muscular and skeletal organs."} -{"_id": 4313, "text": "An amino acid metabolic disorder that is an autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid causing progressive brain damage."} -{"_id": 4316, "text": "A dermatomycosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi which are not dermatophytes and has_symptom opaque nail, has_symptom yellow-brown nail, has_symptom crumbly nail that can separate from the nail bed."} -{"_id": 4319, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis."} -{"_id": 4322, "text": "A cell type benign neoplasm that has_material_basis_in glial-type cells."} -{"_id": 4325, "text": "A spondyloepimetaphyseal dysplasia that is characterized by spondylar and nasal changes, with striations of the metaphyses that has_material_basis_in autosomal recessive inheritance."} -{"_id": 4328, "text": "A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite (\\comfort eating\\\"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.\""} -{"_id": 4331, "text": "A primary systemic mycosis that results_in fungal infection located_in lungs, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom lung lesions, has_symptom pleural thickening and results_in_formation_of pulmonary nodules."} -{"_id": 4334, "text": "An adenovirus infectious disease that involves inflammation of the liver caused by Human adenovirus 1, has_material_basis_in Human adenovirus 2, or has_material_basis_in Human adenovirus 5. The symptoms include fever, coagulopathy and gastrointestinal bleeding. Histopathological examination reveals widespread hepatic necrosis with hemorrhage."} -{"_id": 4337, "text": "An ovarian carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 4340, "text": "A basal ganglia disease characterized by the presence of abnormal calcium deposits of unknown cause in the brain; has symptom dementia, psychosis, mood swings and loss of acquired motor skills."} -{"_id": 4343, "text": "A cervical carcinosarcoma is located_in the cervix with morphological features resembling Wilms tumor of the kidney."} -{"_id": 4346, "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Tahyna virus, which is transmitted_by Aedes, transmitted_by Culex, and transmitted_by Ochlerotatus mosquitoes. The infection has_symptom headache, has_symptom fever, has_symptom anorexia, and has_symptom seizures."} -{"_id": 4349, "text": "A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting."} -{"_id": 4352, "text": "An African histoplasmosis that results_in inflammation located_in meninges, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and results_in_formation_of focal mass lesions, has_symptom headache, has_symptom confusion, has_symptom decreased level of consciousness, has_symptom cranial nerve deficits, and has_symptom seizures."} -{"_id": 4355, "text": "A pharynx cancer that is located_in the hypopharynx."} -{"_id": 4358, "text": "A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect."} -{"_id": 4361, "text": "A cell type benign neoplasm that has_material_basis in mesothelium."} -{"_id": 4364, "text": "A drug dependence that is a psychological dependency on the regular use of cocaine."} -{"_id": 4367, "text": "A goiter characterized by a multinodular enlargement of the thyroid gland."} -{"_id": 4370, "text": "A peritoneum cancer that develops from cells of the mesothelium and is located_in the peritoneum."} -{"_id": 4373, "text": "A malaria characterized as a vector-borne infectious disease of birds caused by protozoan parasites Plasmodium relictum, Plasmodium anasum or Plasmodium gallinaceum, which are transmitted by Culex quinquefasciatus mosquitoes, causing anemia."} -{"_id": 4376, "text": "A movement disease characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain."} -{"_id": 4379, "text": "A spastic cerebral palsy that affects one side of the body resulting in stiff arm, hand and leg. On the affected side,the arm and leg may not develop normally."} -{"_id": 4382, "text": "A Parkinson's disease caused by heterozygous mutation in the gene encoding dardarin , LRRK2, located on chromosome 12q12."} -{"_id": 4385, "text": "A crustacean allergy triggered by Fenneropenaeus indicus."} -{"_id": 4388, "text": "An amebiasis that involves infection of the intestine with the protozoan parasite Entamoeba histolytica trophozoites resulting in intermittent nondysenteric diarrhea with abdominal pain, mucus, flatulence, and weight loss. Chronic infection manifests as tender, palpable masses or annular lesions (amebomas) in the cecum and ascending colon."} -{"_id": 4391, "text": "A fruit allergy triggered by Malus domestica plant fruit food product."} -{"_id": 4394, "text": "A toxoplasmosis that occurs in patients with AIDS or weakened immune system, who develop the infection due to reactivation, present with ring-enhancing intracranial mass lesions or encephalitis. The symptoms include headache, altered mental status, seizures, coma, fever, motor or sensory loss, cranial nerve palsies, visual abnormalities, and focal seizures."} -{"_id": 4397, "text": "A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain."} -{"_id": 4400, "text": "A mitochondrial metabolism disease characterized by a wide range of manifestations including marked and often fatal lactic acidosis, cardiomyopathy, leukoencephalopathy, pure myopathy and hepatopathy with tubulopathy. Among the numerous clinical phenotypes observed are Leigh syndrome, Leber hereditary optic neuropathy and MELAS syndrome. It can be caused by mutations in multiple different genes, both nuclear-encoded and mitochondrial-encoded."} -{"_id": 4403, "text": "A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host."} -{"_id": 4406, "text": "A viral infectious disease that involves necrosis of the liver caused by Canine adenovirus 1 in dogs, wolves, coyotes and bears. The symptoms include fever, leukopenia, apathy, anorexia, conjunctivitis, serous discharge from the eyes and nose, petechiae of the oral mucosa, subcutaneous edema of the head, neck and trunk, hematomas in the mouth, jaundice, and hepatic encephalopathy."} -{"_id": 4409, "text": "A vascular disease that is located_in the liver."} -{"_id": 4412, "text": "A nephritis that causes inflammation of the glomeruli located_in kidney."} -{"_id": 4415, "text": "A pre-eclampsia characterized by the presence of seizures."} -{"_id": 4418, "text": "An organ system benign neoplasm located_in the immune system organs."} -{"_id": 4421, "text": "A central nervous system lipoma that is characterized by abnormal fat accumulation in and around the spinal cord."} -{"_id": 4424, "text": "A neuropathy that affect the nerves that control the voluntary muscles."} -{"_id": 4427, "text": "A thoracic cancer that is located_in the chest wall."} -{"_id": 4430, "text": "A syphilis that is the first stage of syphilis, marked by the development of a chancre, which is characterized by mononuclear leukocytic infiltration, macrophages, and lymphocytes."} -{"_id": 4433, "text": "A Mumps virus infectious disease that results_in inflammation located_in pancreas, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom abdominal pain, has_symptom chills, has_symptom fever, and has_symptom persistent vomiting."} -{"_id": 4436, "text": "A malignant melanoma of iris and spindle cell intraocular melanoma that is located_in the iris."} -{"_id": 4439, "text": "A Paramyxoviridae infectious disease that results_in infection, has_material_basis_in Respirovirus, which is transmitted_by contact with the respiratory secretions of an infected person."} -{"_id": 4442, "text": "A color blindness that is characterized by a congenital cone color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels has_material_basis_in autosomal recessive inheritance."} -{"_id": 4445, "text": "A dsDNA-RT virus infectious disease that results_in infection in animals and humans, located_in liver, has_material_basis_in Hepadnaviridae viruses."} -{"_id": 4448, "text": "A severe combined immunodeficiency that is the result of a mutation on Chromosome 6 RAG1 gene involving genetic rearrangement of both the T- and B-lymphocyte receptor genes."} -{"_id": 4451, "text": "A bile duct carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 4454, "text": "A gastrointestinal system cancer that is located_in the stomach."} -{"_id": 4457, "text": "An autosomal recessive cerebellar ataxia that is characterized by congenital onset of nonprogressive cerebellar ataxia, disturbed equilibrium, and mental retardation, associated with cerebellar hypoplasia."} -{"_id": 4460, "text": "A toxoplasmosis that results from reactivation of congenital toxoplasmosis, but rarely with acquired infection. Focal necrotizing retinitis and a secondary granulomatous inflammation of the choroid occur. The symptoms include conjunctivitis, ocular pain, blurred vision, and blindness."} -{"_id": 4463, "text": "A lung cancer that is located_in the lung and that arises from transformed cells of mesenchymal origin."} -{"_id": 4466, "text": "A heavy chain disease that results from an overproduction of alpha antibodies (IgA)."} -{"_id": 4469, "text": "A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores."} -{"_id": 4472, "text": "An osteogenesis imperfecta characterized by craniosynostosis, communicating hydrocephalus, ocular proptosis, marked postnatal growth failure, and distinctive facial appearance."} -{"_id": 4475, "text": "An abdominal tuberculosis that results_in formation of granulomas or abscesses located_in spleen."} -{"_id": 4478, "text": "A trichostrongyloidiasis that involves infection of the small intestine with Trichostrongylus colubriformis or Trichostrongylus axei, which results in abdominal pain, diarrhea, anorexia, headache, fatigue, anemia and eosinophilia."} -{"_id": 4481, "text": "A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia."} -{"_id": 4484, "text": "A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years."} -{"_id": 4487, "text": "An urogenital tuberculosis that results_in formation of granulomas located_in kidney."} -{"_id": 4490, "text": "A bone cancer that has_material_basis in neural crest cells derived_from undeveloped, undifferentiated neuroectoderm."} -{"_id": 4493, "text": "A methylmalonic aciduria that is characterized by combined homocystinuria and methylmalonic aciduria and deficiency of MCM and MS activities."} -{"_id": 4496, "text": "A urinary system disease which consists of the presence of bacteria in urine."} -{"_id": 4499, "text": "A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults."} -{"_id": 4502, "text": "A bladder carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 4505, "text": "A schistosomiasis that is a short-term, cutaneous inflammatory response associated with penetration of the skin by cercariae of bird schistosome, Austrobilharzia variglandis. The disease has_symptom skin reddening, has_symptom skin itching, in the water or immediately after emerging and has_symptom itchy, raised papules, occur within hours of infection."} -{"_id": 4508, "text": "A glycogen storage disease characterized by enlargement of the liver, moderately low blood sugar, elevated levels of acetone and other ketone bodies in the blood and moderate growth retardation."} -{"_id": 4511, "text": "A opisthorchiasis that involves parasitic infection of the liver, biliary ducts, pancreas and pancreatic ducts by Opisthorchis viverrini. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma."} -{"_id": 4514, "text": "A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis."} -{"_id": 4517, "text": "An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs."} -{"_id": 4520, "text": "A tuberculosis that is a chronic and progressive wasting and weakness caused by infection of companion, captive exotic, wild and domestic birds with Mycobacterium avium complex (serotypes 1, 2 and 3) and M. genavense."} -{"_id": 4523, "text": "A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever."} -{"_id": 4526, "text": "A brain cancer that is located_in the supratentorial region."} -{"_id": 4529, "text": "An ampulla of Vater carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 4532, "text": "A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness."} -{"_id": 4535, "text": "A movement disease that is of unknown etiology characterized by progressive rigidity."} -{"_id": 4538, "text": "A parasitic protozoa infectious disease that involves infection of the cornea of the eye with Acanthamoeba in people wearing contact lenses. The symptoms include eye pain, eye redness, blurred vision, sensitivity to light, excessive tearing and sensation of something in the eye."} -{"_id": 4541, "text": "A cancer of urethra that has recurred after it has been treated. The cancer may come back in the urethra or in other parts of the body."} -{"_id": 4544, "text": "An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite."} -{"_id": 4547, "text": "A gastrointestinal system disease that is located_in the stomach."} -{"_id": 4550, "text": "A spondyloepiphyseal dysplasia characterized by short stature with hyperpigmented macules and an unusual facies, proteinuria with progressive renal failure, lymphopenia with recurrent infections, and cerebral ischaemia. It is caused by mutations in the SMARCAL1 gene."} -{"_id": 4553, "text": "A bone inflammation disease that results_in inflammation located_in epicondyle."} -{"_id": 4556, "text": "A superficial mycosis that results_in fungal infection of the outermost layer located_in skin and located_in hair shaft, has_material_basis_in Ascomycota phylum members."} -{"_id": 4559, "text": "A cryptococcosis that results_in inflammation located_in lungs, has_material_basis_in Cryptococcus neoformans which results_in_formation_of nodular lesions and results_in_formation_of lobar consolidation in the lungs of the immunocompetent patient and has_symptom cough, has_symptom chest pain and has_symptom difficulty breathing."} -{"_id": 4562, "text": "A Yersinia infectious disease that involves infection of the intestine caused by Yersinia enterocolitica. The symptoms include fever, abdominal pain, and diarrhea (often bloody in children)."} -{"_id": 4565, "text": "An ureter cancer that is located_in the ureter."} -{"_id": 4568, "text": "A hypotrichosis that is characterized by a loss of hair from the head or body."} -{"_id": 4571, "text": "An intellectual disability that is characterized by the absence of associated medical and behavioral signs and symptoms."} -{"_id": 4574, "text": "A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage."} -{"_id": 4577, "text": "A viral infectious disease that has_material_basis in Zika virus, which is transmitted_by Aedes aegypti mosquitoes."} -{"_id": 4580, "text": "A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity."} -{"_id": 4583, "text": "A fish allergy triggered by Danio rerio."} -{"_id": 4586, "text": "A colitis that can only be diagnosed_by the examination of colon tissue under a microscope."} -{"_id": 4589, "text": "A serine deficiency that has_material_basis_in deficiency of phosphoglycerate dehydrogenase which results in a disruption of L-serine biosynthesis."} -{"_id": 4592, "text": "An autosomal recessive disease caused by homozygous mutation the SNAP29 gene and characterized by a unique constellation of clinical manifestations including microcephaly, severe neurologic impairment, psychomotor retardation, failure to thrive, facial dysmoprhism, palmoplantar keratoderma and late-onset ichthyosis."} -{"_id": 4595, "text": "A gastrointestinal system cancer that is located_in the oral cavity."} -{"_id": 4598, "text": "A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin."} -{"_id": 4601, "text": "A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions."} -{"_id": 4604, "text": "A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus."} -{"_id": 4607, "text": "A skeletal muscle cancer that arise from skeletal muscle progenitors."} -{"_id": 4610, "text": "A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice."} -{"_id": 4613, "text": "A capillariasis that involves infection of the liver with Capillaria, which manifests as an acute or subacute hepatitis with eosinophilia. The symptoms include abdominal pain, fever, chills, hepatitis, ascites, hepatolithiasis, and hepatomegaly."} -{"_id": 4616, "text": "A syndrome characterized by polyhydramnios with neonatal macrosomia, nephromegaly, distinctive facial appearance, renal dysplasia, nephroblastomatosis, and predisposition to Wilms tumor. It shows similarities to Beckwith-Wiedemann syndrome."} -{"_id": 4619, "text": "A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host."} -{"_id": 4622, "text": "A disease that manifests in a defined anatomical structure."} -{"_id": 4625, "text": "A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule."} -{"_id": 4628, "text": "A pharynx cancer that is located_in the nasopharynx, the uppermost region of the pharynx or \\throat\\\", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.\""} -{"_id": 4631, "text": "An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males."} -{"_id": 4634, "text": "An amino acid metabolic disorder characterized by the body's inability to effectively break down lysine, arginine and ornithine and by renal hyperdiaminoaciduria, especially lysinuria, and by impaired formation of urea with hyperammonemia after protein ingestion. It is caused by homozygous or compound heterozygous mutation in the amino acid transporter gene SLC7A7 on chromosome 14q11."} -{"_id": 4637, "text": "A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells."} -{"_id": 4640, "text": "A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter."} -{"_id": 4643, "text": "A cancer of urethra that shows squamous cell differentiation."} -{"_id": 4646, "text": "A muscular dystrophy that is an autosomal recessive disorder present at birth, which may result in contractures, scoliosis, respiratory and swallowing difficulties, and foot deformities."} -{"_id": 4649, "text": "A syndrome characterized by distinctive facial features including hypertelorism, large eyelid openings, ptosis, high-arched eyebrows, a broad nasal bridge and tip of the nose, a long space between the nose and the upper lip, full cheeks and a pointed chin; structural abnormalities of the brain might also be present."} -{"_id": 4652, "text": "A lipid metabolism disorder that involves defects in steroid metabolism."} -{"_id": 4655, "text": "A type of ALS caused_by mutation located_in FUS gene located_in chromosome 16."} -{"_id": 4658, "text": "A parasitic helminthiasis infectious disease that has_material_basis_in Taenia solium or has_material_basis_in Taenia saginata, which are transmitted_by ingestion of undercooked contaminated meat."} -{"_id": 4661, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis."} -{"_id": 4664, "text": "A syndrome characterized by multiple congenital anomalies and mental retardation. Other characteristics include a peculiar facial gestalt, short stature, skeletal and visceral abnormalities, cardiac anomalies, and immunological defects."} -{"_id": 4667, "text": "A neuromuscular disease that is characterized by the disfunction of conduction through the neuromuscular junction."} -{"_id": 4670, "text": "A frontal sinusitis which lasts for 12 weeks or more. This causes steady headache, localized tenderness and intermittent, purulent nasal and postnasal drainage."} -{"_id": 4673, "text": "An anal canal cancer that derives_from epithelial cells."} -{"_id": 4676, "text": "An bone structure disease that involves degeneration between vertebra located_in vertebral column."} -{"_id": 4679, "text": "A otitis externa which is a microbial infection that occurs suddenly, rapidly worsens, and becomes very painful and alarming. It is caused by swimming in polluted water, scratching the ear or inside the ear and object stuck in the ear. It is occasionally associated with middle ear infection or upper respiratory infections such as colds."} -{"_id": 4682, "text": "A stromal sarcoma and sarcoma of prostate and tumor of specialized prostatic stroma that is located_in the prostate."} -{"_id": 4685, "text": "An inherited metabolic disorder that involves metabolic disturbances in the processing or distribution of dietary minerals."} -{"_id": 4688, "text": "A primary immunodeficiency disease that involves multiple components of the immune system, including both humoral immunity and cell-mediated immunity."} -{"_id": 4691, "text": "An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene."} -{"_id": 4694, "text": "A spotted fever that has_material_basis_in Rickettsia japonica, which is transmitted_by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has_symptom fever, has_symptom eschars, has_symptom regional adenopathy, and has_symptom rash on extremities."} -{"_id": 4697, "text": "A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks."} -{"_id": 4700, "text": "An Alphavirus infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, has_material_basis_in Venezuelan equine encephalitis virus, or has_material_basis_in Western equine encephalomyelitis virus, which are transmitted_by moquito bite. The infection has_symptom fever, has_symptom headache, and has_symptom malaise."} -{"_id": 4703, "text": "A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip."} -{"_id": 4706, "text": "A Rubella virus infectious disease that results_in inflammation located_in liver, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection results in hepatic necrosis."} -{"_id": 4709, "text": "A bone remodeling disease that has_material_basis_in \\nimpaired mineralization or calcification of bones before epiphyseal closure due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium which results_in softening and deformity located_in bone."} -{"_id": 4712, "text": "A central nervous system cancer that is located_in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer)."} -{"_id": 4715, "text": "An anogenital venereal wart that results_in infection located_in mucosa of vagina, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct sexual contact with the skin of an infected partner. The infection has_symptom vaginal warts."} -{"_id": 4718, "text": "An embryonal carcinoma that is located_in the testis."} -{"_id": 4721, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection."} -{"_id": 4724, "text": "A multifocal dystonia that involves the arm and leg on the same side of the body."} -{"_id": 4727, "text": "A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars."} -{"_id": 4730, "text": "A vaginal benign neoplasm that is characterized by the presence of a fibrovascular stalk lined by normal squamous epithelium."} -{"_id": 4733, "text": "A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever."} -{"_id": 4736, "text": "An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period."} -{"_id": 4739, "text": "A trypanosomiasis that involves inflammation of the meninges caused due to Trypanosoma species."} -{"_id": 4742, "text": "An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 4745, "text": "A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder."} -{"_id": 4748, "text": "A B-cell lymphoma that is characterized by initial formation in the marginal zones of lymph tissue."} -{"_id": 4751, "text": "An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma, arising from an anatomic site other than the liver."} -{"_id": 4754, "text": "An X-linked disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait."} -{"_id": 4757, "text": "A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue."} -{"_id": 4760, "text": "A colonic disease that is characterized by an abnormal dilation of the colon."} -{"_id": 4763, "text": "A teeth hard tissue disease characterized by presence of normal enamel but atypical dentin with abnormal pulpal morphology."} -{"_id": 4766, "text": "A Charcot-Marie-Tooth disease that is characterized optic atrophy followed by retinitis pigmentosa."} -{"_id": 4769, "text": "A uterine corpus cancer that is characterized histologically by papillae with fibrovascular cores, marked nuclear atypia, psammoma bodies and cilia."} -{"_id": 4772, "text": "A cell type benign neoplasm that is composed_of a mixture of gonadal elements."} -{"_id": 4775, "text": "A chordoma that histologically derives_from chordoma, derives_from chondroma, and derives_from chondrosarcoma."} -{"_id": 4778, "text": "A blue drum syndrome caused by an allergen."} -{"_id": 4781, "text": "An urogenital tuberculosis that results_in formation of granulomas located_in fallopian tube."} -{"_id": 4784, "text": "An ectothrix infectious disease that results_in zoophilic fungal infection located_in skin, and located_in hair, has_material_basis_in Microsporum distortum, which causes infections in cats, dogs and other animals."} -{"_id": 4787, "text": "A stomach cancer that is located_in the stomach."} -{"_id": 4790, "text": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart."} -{"_id": 4793, "text": "A tracheal disease characterized by flaccidity of the tracheal support cartilage."} -{"_id": 4796, "text": "A central nervous system disease that results_in the progressive deterioration of function or structure of neurons."} -{"_id": 4799, "text": "A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times."} -{"_id": 4802, "text": "A night blindness that is characterized by hemeralopia with a moderate loss of visual acuity and caused by defective photoreceptor-to-bipolar cell signaling with common ERG findings of reduced or absent b-waves and generally normal a-waves."} -{"_id": 4805, "text": "A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision."} -{"_id": 4808, "text": "A functioning pituitary adenoma that characterized by excess cortisol a primary cause of Cushing's syndrome."} -{"_id": 4811, "text": "A disease that is present at birth due to a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment."} -{"_id": 4814, "text": "A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing."} -{"_id": 4817, "text": "A syndrome that involves occipital head aches, nystagmus on head movement, tinnitus, spasms, blurred vision, corneal hyperaesthesia, and corneal ulcers."} -{"_id": 4820, "text": "A disease of anatomical entity that is located_in the gastrointestinal tract."} -{"_id": 4823, "text": "A viral infectious disease that results_in infection in mammals, has_material_basis_in Pestivirus, which is transmitted_by contact with nasal secretions of an infected animal. The infection has_symptom diarrhea, has_symptom respiratory problems, and has_symptom bleeding disorder."} -{"_id": 4826, "text": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from mesenchymal cells."} -{"_id": 4829, "text": "A viral infectious disease that results_in infection in birds, has_material_basis_in Avian leukosis virus, which causes wide range of tumors."} -{"_id": 4832, "text": "A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure."} -{"_id": 4835, "text": "A lipid metabolism disorder characterized by malnutrition, failure to thrive, growth failure, vitamin E deficiency and the absence of chylomicrons and apolipoprotein B48 post-prandially. It has an autosomal recessive inheritance pattern and is caused by mutations in the SAR1B gene located in chromosome 5q31.1."} -{"_id": 4838, "text": "A gastrointestinal system benign neoplasm located_in the hepatobiliary system."} -{"_id": 4841, "text": "A colorectal cancer that derives_from epithelial cells of glandular origin."} -{"_id": 4844, "text": "A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma."} -{"_id": 4847, "text": "An adenocarcinoma that derives_from epithelial cells which have clear cytoplasm."} -{"_id": 4850, "text": "An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate."} -{"_id": 4853, "text": "A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide."} -{"_id": 4856, "text": "A otitis externa which involves bacterial infections often related to underlying comorbidities as well as trauma. Common sources of trauma include ear piercing, boxing, blunt trauma, burns, bite wounds and iatrogenic insults. The common bacterial pathogens are staphylococcal and streptococcal species."} -{"_id": 4859, "text": "A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes."} -{"_id": 4862, "text": "An ocular cancer that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells and arises_from the tissues that cover structures located_in the eye."} -{"_id": 4865, "text": "A syndrome characterized by progressive weakness and atrophy of muscles in feet, legs and hands. In some patients the syndrome also causes decreased sensitivity to touch, heat or cold, particularly in the lower arms or legs."} -{"_id": 4868, "text": "A rectum sarcoma that is a smooth muscle tumor and is located_in the rectum."} -{"_id": 4871, "text": "A type of ALS caused_by mutation located_in VCP gene located_in chromosome 9."} -{"_id": 4874, "text": "A diphtheria that involves a bluish white membrane formation on the faucial pillars, uvula, soft palate and tonsils."} -{"_id": 4877, "text": "A syndactyly characterized by an increased number of digits; often a result of a mutation in the HOX D13 gene."} -{"_id": 4880, "text": "A candidiasis that involves fungal infection of the oropharynx in immunocompromised patients caused by Candida species resulting in formation of white plaques on the buccal mucosa, tongue, gums, palate, or pharynx. The symptoms include burning or dryness of the mouth, loss of taste, and pain on swallowing."} -{"_id": 4883, "text": "A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells."} -{"_id": 4886, "text": "An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development."} -{"_id": 4889, "text": "An aortic aneurysm that is located_in the abdominal aorta."} -{"_id": 4892, "text": "A gender identity disorder that is characterized by having a sexual orientation or an attraction that is at odds with one's idealized self-image, causing anxiety and a desire to change one's orientation or become more comfortable with one's sexual orientation."} -{"_id": 4895, "text": "A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has_symptom soft-tissue swelling, has_symptom bone lesions, and has_symptom irritability."} -{"_id": 4898, "text": "An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue."} -{"_id": 4901, "text": "A lymphoblastic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood."} -{"_id": 4904, "text": "An autosomal dominant disease characterized by abnormal development of ectodermal tissues including the skin, hair, nails, teeth and sweat glands and anhidrotic ectodermal dysplasia with cleft lip/palate."} -{"_id": 4907, "text": "A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis."} -{"_id": 4910, "text": "A psychotic disorder that involves schizophrenia symptoms over time period of one month."} -{"_id": 4913, "text": "A bone structure disease that involves a defect located_in lumbar vertebral column."} -{"_id": 4916, "text": "A malignant giant cell tumor that is composed_of multinucleated giant cells."} -{"_id": 4919, "text": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis."} -{"_id": 4922, "text": "An amino acid metabolic disorder that involves an accumulation of homocysteine in the serum and an increased excretion of homocysteine in the urine."} -{"_id": 4925, "text": "An ischemic bone disease that results_in necrosis located_in bone."} -{"_id": 4928, "text": "A blepharitis that is characterized by an infection of the sebaceous glands of Zeis at the base of the eyelashes, or an infection of the apocrine sweat glands of Moll."} -{"_id": 4931, "text": "A commensal streptococcal infectious disease that is caused due to the infection by group A streptococci, of which Streptococcus pyogenes is the most important pathogen. The infection results in the development of empyema, pneumothorax, and cyst."} -{"_id": 4934, "text": "An uterine corpus cancer that is located_in the muscles of the uterus or located_in other tissues that support the uterus."} -{"_id": 4937, "text": "A opportunistic mycosis that results_in fungal infection located_in gastrointestinal tract, has_material_basis_in Mucorales molds in immunocompromised patients, results_in_formation_of intra-abdominal abscess and has_symptom abdominal pain, has_symptom distention, has_symptom nausea, and has_symptom vomiting."} -{"_id": 4940, "text": "A syndrome that is characterized by progressive proximal muscle weakness, steolytic bone lesions consistent with Paget disease, and frontotemporal dementia and has_physical_basis_in mutation in the valosin containing protein (VCP)."} -{"_id": 4943, "text": "A syndrome that is characterized by sensorineural hearing loss with onset in infancy, followed in adolescence by progressive optic nerve atrophy with loss of vision and in adulthood by progressive dementia."} -{"_id": 4946, "text": "A perichondritis of auricle which is persistent and long-lasting."} -{"_id": 4949, "text": "A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses."} -{"_id": 4952, "text": "A migraine that is characterized by migraine headaches that are not accompanied by an aura."} -{"_id": 4955, "text": "A Varicellovirus infectious disease that results_in infection located_in peripheral nervous system in swine, cattle, sheep, dogs and raccoons, has_material_basis_in Suid herpesvirus 1 and has_symptom abortion, has_symptom coughing, has_symptom sneezing, has_symptom fever, has_symptom constipation, has_symptom depression, has_symptom seizures, has_symptom ataxia, has_symptom circling, has_symptom excess salivation in piglets, and has_symptom intense itching in cattle."} -{"_id": 4958, "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye."} -{"_id": 4961, "text": "A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Treponema carateum, which is transmitted_by contact with skin and mucous membrane of an infected person. The infection has_symptom pruritic plaque, which slowly enlarges and becomes pigmented and hyperkeratotic."} -{"_id": 4964, "text": "A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes."} -{"_id": 4967, "text": "An agnosia that is a loss of the ability to recognize familiar voices."} -{"_id": 4970, "text": "A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood."} -{"_id": 4973, "text": "An autosomal recessive disease characterized by callosal agenesis, cataracts, cardiomyopathy, combined\\nimmunodeficiency and hypopigmentation. It is caused by mutation in the EPG5 gene located in chromosome 18q12.3."} -{"_id": 4976, "text": "A bone cancer that is located_in almost exclusively in the long bones."} -{"_id": 4979, "text": "A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising caused by a heritable defect in collagen synthesis, which leads to marked healing difficulties. EDS has five cardinal signs, which may be present to some degree in all of the subtypes. These five cardinal signs are skin fragility, blood vessel fragility, skin hyperelasticity, joint hypermobility, and characteristic subcutaneous nodules."} -{"_id": 4982, "text": "A brucellosis that involves an infection caused by Brucella abortus in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia."} -{"_id": 4985, "text": "A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs."} -{"_id": 4988, "text": "A cutaneous mycosis that results_in fungal infection located_in skin, located_in hair and located_in nail, has_material_basis_in Ascomycota phylum members."} -{"_id": 4991, "text": "An Enterovirus infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Human echovirus 11, which is transmitted_by contaminated drinking water. The infection has_symptom diarrhea."} -{"_id": 4994, "text": "An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract."} -{"_id": 4997, "text": "A candidiasis that involves fungal infection of the mucous membrane of the mouth by Candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes."} -{"_id": 5000, "text": "A female reproductive system disease that is located_in the uterus."} -{"_id": 5003, "text": "A childhood kidney neoplasm that is located_in the in the kidney as well as other locations outside the kidneys such as the liver, muscle, heart, lung, soft tissues, skin, the central nervous system."} -{"_id": 5006, "text": "An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building."} -{"_id": 5009, "text": "A sarcoma that results_in the formation of numerous sarcomas or located_in various parts of the body."} -{"_id": 5012, "text": "An eye disease characterized by nonsyphilitic interstitial keratitis located_in cornea, has_symptom fever, has_symptom fatigue."} -{"_id": 5015, "text": "A schistosomiasis that involves parasitic infection of domestic animals caused by a trematode fluke Schistosoma bovis."} -{"_id": 5018, "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase."} -{"_id": 5021, "text": "An Escherichia coli intestinal infectious disease that involves infection of the intestine caused by a serological subgroup of Escherichia coli called enterotoxigenic Escherichia coli (ETEC), which are non-invasive and produce heat-labile enterotoxin (LT) or heat stable toxin (ST). The bacteria colonize the GI tract by means of a fimbrial adhesin. The symptoms include diarrhea without fever."} -{"_id": 5024, "text": "An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones."} -{"_id": 5027, "text": "A respiratory system cancer that is located_in the trachea."} -{"_id": 5030, "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the urethra caused by Trichomonas vaginalis, which results in pain during urination."} -{"_id": 5033, "text": "A shellfish allergy triggered by Mollusca."} -{"_id": 5036, "text": "A filarial elephantiasis that involves parasitic infection of the lymphatic system by a filarial worm Wuchereria bancrofti, which is transmitted by mosquitoes. The symptoms include lymphedema, fever, chills, skin infections, painful lymph nodes, orchitis and epididymitis."} -{"_id": 5039, "text": "A syndrome characterized by craniofacial, neurologic, limb and ocular abnormalities."} -{"_id": 5042, "text": "A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm."} -{"_id": 5045, "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the foreskin and glans in uncircumcised males caused by Trichomonas vaginalis resulting in redness of foreskin or penis, rash on the head of penis, foul-smelling discharge, and painful penis and foreskin."} -{"_id": 5048, "text": "A pertussis that is a milder disease caused by the bacterium Bordetella parapertussis. The disease has_symptom coughing, has_symptom sneezing, or has_symptom runny nose ."} -{"_id": 5051, "text": "A cancer that is classified based on the organ it starts in."} -{"_id": 5054, "text": "A viral infectious disease that results_in_formation_of vesicles located_in epithelium of the snout, lips, nostrils, tongue, feet and mammary glands of swine, has_material_basis_in Vesicular exanthema of swine virus, which is transmitted_by direct contact."} -{"_id": 5057, "text": "A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function."} -{"_id": 5060, "text": "An echinococcosis that is caused by the larvae of Echinococcus vogeli or Echinococcus oligarthrus, which infect the liver."} -{"_id": 5063, "text": "A sarcoma of the mediastinum and synovial sarcoma that is located_in the mediastinum."} -{"_id": 5066, "text": "A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma."} -{"_id": 5069, "text": "A urinary system cancer that is located_in the ureter."} -{"_id": 5072, "text": "A parasitic ectoparasitic infectious disease that involves parasitic infestation by members of the subclass Hirudinea. The leeches remain attached to their hosts and feed on blood until they become full, at which point they fall off to digest. While feeding, they release an anesthetic and use a combination of mucus and suction to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream."} -{"_id": 5075, "text": "A bone cancer that is located_in bone that has_material_basis_in cells of mesenchymal origin."} -{"_id": 5078, "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Snowshoe hare virus, which is transmitted_by Aedes mosquitoes. The infection has_symptom headache, has_symptom fever, has_symptom anorexia, and has_symptom seizures."} -{"_id": 5081, "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Human torovirus, which is transmitted_by ingestion of food contaminated with feces. The infection has_symptom bloody diarrhea."} -{"_id": 5084, "text": "An autosomal dominant disease characterized by congenital anomalies located_in heart and located_in upper limb."} -{"_id": 5087, "text": "A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain."} -{"_id": 5090, "text": "A human papillomavirus related adenocarcinoma that results_in infection, located_in endocervix, has_material_basis_in human papillomaviruses (types 16, 18, 31, 39 or 45), which cause lesions that progress to cancers."} -{"_id": 5093, "text": "A pyrimidine metabolic disorder that is characterized by an excessive secretion of orotic acid in urine."} -{"_id": 5096, "text": "A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Pseudallescheria boydii, which results_in_formation_of abscesses."} -{"_id": 5099, "text": "An asthma that is a life threatening condition with progressive respiratory failure, which does not respond to standard treatment."} -{"_id": 5102, "text": "A keratosis characterized_by keratinizing squamous epithelium located_in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction."} -{"_id": 5105, "text": "An adult sarcoma of soft tissue and mesenchymal chondrosarcoma that is located_in the cartilage."} -{"_id": 5108, "text": "A viral infectious disease that results_in infection, has_material_basis_in Human herpesvirus 4, which is transmitted_by contact with the saliva."} -{"_id": 5111, "text": "A (-)ssRNA virus infectious disease that results_in infection in rodents and humans, has_material_basis_in Arenaviridae viruses."} -{"_id": 5114, "text": "A syndrome characterized by distinctive facial appearance, a cluster of minor and major anomalies and central nervous system dysfunction."} -{"_id": 5117, "text": "A parasitic protozoa infectious disease involving infection caused by Balantidium coli. The trophozoites are capable of attacking the intestinal epithelium, creating ulcers and causing bloody diarrhea. The infectiou has_symptom cramping, has_symptom abdominal pain, has_symptom nausea and has_symptom foul breath."} -{"_id": 5120, "text": "A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis."} -{"_id": 5123, "text": "A sarcoma that affects adults and is located_in the muscle, located_in fat, located_in fibrous tissue, located_in blood vessels, or located_in other supporting tissue of the body."} -{"_id": 5126, "text": "A ethmoid sinusitis which lasts for less than 4 weeks."} -{"_id": 5129, "text": "An acrocephalosyndactylia characterized by abnormalities in the bones of the legs, congenital heart defects and craniofacial defects and craniosynostosis. The patients suffer from cyanosis and other respiratory and breathing infections."} -{"_id": 5132, "text": "A rickets that has_material_basis_in increased serum 1,25-dihydroxyvitamin D levels and increased intestinal calcium absorption and is characterized by the presence of hypophosphatemia secondary to renal phosphate wasting, radiographic and/or histologic evidence of rickets, limb deformities, muscle weakness, and bone pain."} -{"_id": 5135, "text": "A vascular disease that is characterized as a small vascular malformation of the gut."} -{"_id": 5138, "text": "A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium."} -{"_id": 5141, "text": "A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others."} -{"_id": 5144, "text": "A lymphatic system disease that is characterized by inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. It is caused by Streptococcus pyogenes (Group A strep) or Staphylococcus aureus. Lymphangitis is also sometimes called blood poisoning."} -{"_id": 5147, "text": "A disorder that is a psychological or behavioral pattern associated with distress or disability that occurs in an individual and is not a part of normal development or culture."} -{"_id": 5150, "text": "A bone remodeling disease that results in an abnormal growth of located_in bone."} -{"_id": 5153, "text": "A hereditary ataxia that has_material_basis_in autosomal dominant inheritance."} -{"_id": 5156, "text": "A cell type benign neoplasm that has_material_basis_in odontogenic epithelium."} -{"_id": 5159, "text": "A sarcoma that results_in cells that are spindle-shaped. They are usually resistant to radiation therapy."} -{"_id": 5162, "text": "A sarcoma and malignant tumor of trachea that is located_in the trachea."} -{"_id": 5165, "text": "A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys."} -{"_id": 5168, "text": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 5171, "text": "A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight."} -{"_id": 5174, "text": "A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed."} -{"_id": 5177, "text": "A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face."} -{"_id": 5180, "text": "A syphilis that results_in a multisystem infection in the fetus via the placenta."} -{"_id": 5183, "text": "A thyroid gland disease that is characterized by excess thyroid hormone."} -{"_id": 5186, "text": "An acrocephalosyndactylia that has_material_basis_in mutations in the FGFR1 and FGFR2 gene which results_in premature fusion located_in skull."} -{"_id": 5189, "text": "A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms."} -{"_id": 5192, "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis."} -{"_id": 5195, "text": "A trichostrongyloidiasis that involves parasitic infection of the ruminant abomasum by nematodes of the genus Haemonchus resulting in anemia, dehydration, diarrhea and accumulation of fluid in the abdomen, gut wall, thoracic cavity and submandibular tissue."} -{"_id": 5198, "text": "A Simplexvirus infectious disease that results_in inflammation located_in cornea of the eye, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, and has_symptom photophobia, has_symptom blurred vision, has_symptom tearing, has_symptom pain, and has_symptom redness."} -{"_id": 5201, "text": "A substance abuse that involves the recurring use of hallucinogenic drugs despite negative consequences."} -{"_id": 5204, "text": "A spotted fever that has_material_basis_in Rickettsia conorii subsp caspia, which is transmitted_by ticks (Rhipicephalus pumilio and Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities."} -{"_id": 5207, "text": "A viral infectious disease that has_material_basis_in human papillomaviruses, which establish productive infections only in the stratified epithelium of the skin or mucous membranes. These viruses cause warts and sometimes tumors. They are transmitted_by sexual contact."} -{"_id": 5210, "text": "A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea."} -{"_id": 5213, "text": "A parasitic ectoparasitic infectious disease that involves parasitic infestation of blood feeding ticks of the families Ixodidae and Argasidae on animals and humans. Ticks are vectors of a number diseases, including Lyme disease, Q fever, Colorado tick fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis and tick-borne meningoencephalitis, as well as anaplasmosis in cattle and canine jaundice."} -{"_id": 5216, "text": "A Varicellovirus infectious disease that results_in inflammation located_in lung, has_material_basis_in Human herpesvirus 3, has_symptom rash, has_symptom tachypnea, has_symptom chest tightness, has_symptom cough, has_symptom dyspnea, has_symptom fever, has_symptom pleuretic chest pain, and has_symptom hemoptysis."} -{"_id": 5219, "text": "An anogenital venereal wart that results_in infection located_in skin of vulva, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct sexual contact with the skin of an infected partner. The infection has_symptom vulvar warts."} -{"_id": 5222, "text": "A skin malanoma that results_in nonpigmented lesions located_in sun-exposed areas of the body, most commonly on the head and neck."} -{"_id": 5225, "text": "A type of ALS caused_by mutation located_in TARDBP gene located_in chromosome 1."} -{"_id": 5228, "text": "An astrocytoma that is characterized as a low grade astrocytoma and has_material_basis_in neoplastic astrocytes."} -{"_id": 5231, "text": "An autosomal dominant disease characterized by abnormal development of the face, skin and genitals. Clinical expressions of the disease include cleft lip, with or without cleft palate, contractures of the lower extremities, abnormal external genitalia, syndactyly of fingers and/or toes, and a pyramidal skin fold over the hallux nail. It is caused by mutations in the IRF6 gene located in chromosome 1."} -{"_id": 5234, "text": "A myeloma that is located_in the plasma cells in bone marrow."} -{"_id": 5237, "text": "A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen."} -{"_id": 5240, "text": "A metaphyseal dysplasia that results_in dwarfism and bowed legs."} -{"_id": 5243, "text": "A hematopoietic system disease characterized by oval or elliptical red blood cells, slight or absent hemolysis with little or no anemia; splenomegaly is often present."} -{"_id": 5246, "text": "A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum."} -{"_id": 5249, "text": "A conjunctival disease characterized by an inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids."} -{"_id": 5252, "text": "An amino acid metabolic disorder that involves phenylalanine and tyrosine metabolism with the accumulation of homogentisic acid, a toxic tyrosine byproduct."} -{"_id": 5255, "text": "An 2-hydroxyglutaric aciduria that involves developmental delay, seizures, weak muscle tone (hypotonia), and abnormalities in the largest part of the brain (the cerebrum), which controls many important functions such as muscle movement, speech, vision, thinking, emotion, and memory."} -{"_id": 5258, "text": "An X-linked disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in X-linked inheritance and a loss of FMR1 function."} -{"_id": 5261, "text": "A learning disability involing difficulty reading resulting primarily from neurological factors which affect any part of the reading process."} -{"_id": 5264, "text": "A primary bacterial infectious disease that has_material_basis_in Francisella tularensis, which is transmitted_by dog tick bite (Dermacentor variabilis), transmitted_by deer flies (Chrysops sp) or transmitted_by contact with infected animal tissues."} -{"_id": 5267, "text": "A commensal bacterial infectious disease that results_in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces gerencseriae, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus, has_material_basis_in Actinomyces meyeri, has_material_basis_in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures."} -{"_id": 5270, "text": "A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE."} -{"_id": 5273, "text": "A viral infectious disease that results_in infection in cattle, located_in intestine, has_material_basis_in Bovine viral diarrhea virus 1, which is transmitted_by ingestion of infected food, or transmitted_by nasal secretions. The infection has_symptom lesions in the mucosa of digestive tract, has_symptom necrosis of lymphoid tissue, has_symptom hoof inflammation and dermatitis, and has_symptom diarrhea."} -{"_id": 5276, "text": "An agnosia that is a loss of the ability to perceive a whole object while perceiving only parts of details."} -{"_id": 5279, "text": "A Charcot-Marie-Tooth disease characterized by motor conduction velocities above and below 38 m/s."} -{"_id": 5282, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by nematodes of the superfamily Trichostrongyloidea."} -{"_id": 5285, "text": "An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months."} -{"_id": 5288, "text": "An osteochondrodysplasia that results_in shortened long bones and distinct facial abnormalities."} -{"_id": 5291, "text": "A trichomoniasis that is caused by a singled-celled protozoan parasite Trichomonas tenax, which is transmitted through oral droplets, by kissing, or on fomites such as eating utensils. Trichomonas tenax causes periodonitis and bronchopulmonary trichomoniasis by aspiration from the oropharynx."} -{"_id": 5294, "text": "An amino acid metabolic disorder that involves abnormally high levels of the amino acid glycine in bodily fluids and tissues."} -{"_id": 5297, "text": "A Simplexvirus infectious disease that results_in inflammation located_in brain and located_in meninges, has_material_basis_in Human herpesvirus 2 and has_symptom headache, has_symptom lesions in the brain, and has_symptom cerebral hemorrhage."} -{"_id": 5300, "text": "A pigmentation disease characterized by progressively pigmented and depigmented macules, often mixed in a reticulate pattern, concentrated on the dorsal extremities."} -{"_id": 5303, "text": "A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity."} -{"_id": 5306, "text": "A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets."} -{"_id": 5309, "text": "A bone development disease characterized by short fingers and toes."} -{"_id": 5312, "text": "A thoracic cancer that originates in the mammary gland."} -{"_id": 5315, "text": "A gastrointestinal anthrax that results_in infection located_in mucosa of oropharynx, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite."} -{"_id": 5318, "text": "An intrinsic cardiomyopathy that has_material_basis_in autosomal dominant inheritance and that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause."} -{"_id": 5321, "text": "A syndrome that involves abnormality of collagen synthesis in lamellar bones, with manifestations limited to the skeleton. The initial symptom is frequently spontaneous fractures."} -{"_id": 5324, "text": "An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image."} -{"_id": 5327, "text": "An extrahepatic bile duct carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 5330, "text": "A uterine corpus cancer that is derived_from the inner lining of the uterus."} -{"_id": 5333, "text": "An autosomal dominant disease characterized by problems with regulating body temperature and other abnormalities affecting many parts of the body; caused_by mutations in the CRLF1 gene."} -{"_id": 5336, "text": "A nutritional deficiency disease that is characterized by thinning of the hair (often with loss of hair color), and red scaly rash around the eyes, nose, and mouth."} -{"_id": 5339, "text": "An autoimmune disease of skin and connective tissue that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested."} -{"_id": 5342, "text": "A malignant melanoma of choroid and spindle cell intraocular melanoma that is located_in the choroid."} -{"_id": 5345, "text": "A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated."} -{"_id": 5348, "text": "A glioblastoma multiforme that is characterized by the most frequent number of mutation of the Neurofibromin 1 gene."} -{"_id": 5351, "text": "An amino acid metabolic disorder that involves accumulation of ammonia in the blood."} -{"_id": 5354, "text": "A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior."} -{"_id": 5357, "text": "A musculoskeletal system disease that affects the muscles."} -{"_id": 5360, "text": "A Chromadorea infectious disease that involves infection by parasitic nematodes of the order Spirurida."} -{"_id": 5363, "text": "A Measles virus infectious disease that results_in inflammation located_in brain, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom headache, has_symptom irritability, has_symptom drowsiness, has_symptom abnormal reflexes, has_symptom involuntary movements, has_symptom hemiplagia, has_symptom ataxia, has_symptom nystagmus, and has_symptom dysphasia."} -{"_id": 5366, "text": "A Salmonella infectious disease that involves inflammation of the stomach and intestines caused by Salmonella infection. The symptoms include diarrhea, vomiting, abdominal pain, fever and weakness."} -{"_id": 5369, "text": "A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring."} -{"_id": 5372, "text": "A hypersensitivity reaction type II disease of the eyes, ears, nose and throat."} -{"_id": 5375, "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Simplexvirus."} -{"_id": 5378, "text": "A carcinoma of bladder that is manifested in squamous cells of the bladder."} -{"_id": 5381, "text": "A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading to hereditary angioedema (HAE) involving swelling due to leakage of fluid from blood vessels into connective tissue."} -{"_id": 5384, "text": "A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements."} -{"_id": 5387, "text": "A mycoplasmal pneumonia that is a highly contagious infection usually associated with pleurisy of cattle, goats, and sheep, which is caused by bacteria of the genus Mycoplasma (especially M. mycoides)."} -{"_id": 5390, "text": "A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells."} -{"_id": 5393, "text": "A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations."} -{"_id": 5396, "text": "A specific phobia that is characterized by a fear of flying."} -{"_id": 5399, "text": "An osteochondrodysplasia that results_in inward turning of lower leg, located_in tibia, which fails to develop normally."} -{"_id": 5402, "text": "A dysostosis that results_in abnormal fusing of adjacent bones."} -{"_id": 5405, "text": "A cardiovascular system disease that involves the heart's electrical conduction system."} -{"_id": 5408, "text": "An ocular cancer that has_material_basis_in melanocytes and is located_in the eye."} -{"_id": 5411, "text": "A Chlamydophila infectious disease that involves Chlamydophila pneumoniae infection, characterized by interstitial infiltrates and respiratory distress."} -{"_id": 5414, "text": "A subcutaneous mycosis that results_in fungal infection located_in skin and located_in subcutaneous tissue, has_material_basis_in Ascomycota phylum members."} -{"_id": 5417, "text": "A herpes simplex that results_in infection located_in skin of the finger, toe, or thumb, has_material_basis_in Human herpesvirus 1 and has_material_basis_in Human herpesvirus 2 and has_symptom lesions, has_symptom fever, and has_symptom swollen lymph nodes."} -{"_id": 5420, "text": "An endocrine system disease that is located_in the pancreas."} -{"_id": 5423, "text": "A kidney sarcoma that has_material_basis_in clear cells that are characterized as cells that look clear when viewed under a microscope."} -{"_id": 5426, "text": "An inflammatory bowel disease characterized by inflammation located_in stomach and located_in duodenum, has_symptom nausea, has_symptom vomiting, has_symptom weight loss and has_symptom loss of appetite."} -{"_id": 5429, "text": "A bone disease that results_in an interruption of blood supply located_in bone."} -{"_id": 5432, "text": "An autosomal dominant disease characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities."} -{"_id": 5435, "text": "A galactosemia that involves an accumulation of galactose and galactitol secondary to the decreased conversion of galactose to galactose-1-phosphate by galactokinase."} -{"_id": 5438, "text": "A vulva carcinoma that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in Bartholin's gland."} -{"_id": 5441, "text": "A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper."} -{"_id": 5444, "text": "A pneumonia located_in the lung parenchyma of unknown cause."} -{"_id": 5447, "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Nidovirales viruses."} -{"_id": 5450, "text": "A colon carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 5453, "text": "A histoplasmosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and results_in_formation_of nodules, results_in_formation_of ulcers and results_in_formation_of osteolytic bone lesions."} -{"_id": 5456, "text": "A B cell deficiency that is caused by a reduction in all types of gamma globulins."} -{"_id": 5459, "text": "A cerebrum cancer that affects the lymph cells and derives_from the brain."} -{"_id": 5462, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis."} -{"_id": 5465, "text": "A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue."} -{"_id": 5468, "text": "A vulva carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 5471, "text": "A physical disorder characterized by mandibular hypoplasia or agnathia, ventromedial auricular malposition (melotia) and/or auricular fusion (synotia), and microstomia with oroglossal hypoplasia or aglossia. Holoprosencephaly is the most commonly identified association, but skeletal, genitourinary and cardiovascular anomalies and situs inversus have been reported."} -{"_id": 5474, "text": "A mental depression that involves presentation of depressive symptoms only during a specific season of the year."} -{"_id": 5477, "text": "A primary bacterial infectious disease that involves infection of the intestine by the bacterium Escherichia coli, caused by consumption of contaminated food and water. Some strains of Escherichia coli produce Shiga toxin, which cause severe illness. The symptoms include severe stomach cramps, fever, diarrhea (sometimes bloody), and vomiting."} -{"_id": 5480, "text": "A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors."} -{"_id": 5483, "text": "A vascular disease that is characterized by blood vessel obstruction resulting from the release of cholesterol from the inside of blood vessels along the bloodstream."} -{"_id": 5486, "text": "An agnosia that is a loss of the ability to visually recognize objects."} -{"_id": 5489, "text": "A parasitic helminthiasis infectious disease that involves infection caused by parasitic worms, which are bilaterian, unsegmented, soft-bodied invertebrate animals with no body cavity."} -{"_id": 5492, "text": "A strongyloidiasis that involves parasitic infection by the filariform larvae of Strongyloides stercoralis, which penetrate the human skin causing urticarial rashes in the buttocks and waist areas."} -{"_id": 5495, "text": "A Varicellovirus infectious disease that results_in infection located_in brain, has_material_basis_in Human herpesvirus 3 and has_symptom lethargy, has_symptom rash, has_symptom confusion, has_symptom hallucinations, has_symptom weakness, has_symptom paralysis, has_symptom numbness, and has_symptom parasthesias."} -{"_id": 5498, "text": "A vascular disease that is located_in the capillaries."} -{"_id": 5501, "text": "An agammaglobulinemia that is a condition where there is co-occurrence of deficient cell-mediated immunity and benign thymoma."} -{"_id": 5504, "text": "A muscular dystrophy which begins at the lower legs and affects the shoulder region earlier and more severely than distal arm."} -{"_id": 5507, "text": "A gallbladder sarcoma that is located_in the gallbladder."} -{"_id": 5510, "text": "A leiomyosarcoma and sarcoma of liver that is located_in the liver."} -{"_id": 5513, "text": "An endocrine gland cancer located_in the pituitary gland located at the base of the brain."} -{"_id": 5516, "text": "A sarcoma and malignant neoplasm of heart that is located_in the heart."} -{"_id": 5519, "text": "A sarcoma of the rectum that results_in lesions that are located_in the rectum."} -{"_id": 5522, "text": "A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize."} -{"_id": 5525, "text": "A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection."} -{"_id": 5528, "text": "An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene."} -{"_id": 5531, "text": "A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding."} -{"_id": 5534, "text": "A cryptococcosis that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Filobasidiella neoformans and has_symptom gastointestinal bleeding, has_symptom diarrhea and has_symptom abdominal pain."} -{"_id": 5537, "text": "A hypersensitivity reaction type II disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots."} -{"_id": 5540, "text": "A communication disorder that involves the processing of linguistic information."} -{"_id": 5543, "text": "A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax."} -{"_id": 5546, "text": "A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation."} -{"_id": 5549, "text": "An Enterovirus infectious disease that results_in inflammation located_in meningeal cluster, has_material_basis_in Human enterovirus B, which is transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom headache, and has_symptom neck pain."} -{"_id": 5552, "text": "An ocular malanoma that derives_from melanocytes in the uveal tract that results_in_formation_of spindle-shaped cells."} -{"_id": 5555, "text": "A viral infectious disease that results_in infection in domesticated housecats, has_material_basis_in Feline immunodeficiency virus, which is transmitted_by contact with the infected cat's saliva during deep bite wounds, and transmitted_by congenital method. The virus attacks the immune system infecting CD4+ and CD8+ T lymphocytes, B lymphocytes, and macrophages. Some of the symptoms are loss of weight, malaise, pyrexia, anemia, gastroenteritis, gingivitis, stomatitis, diarrhea, infections of the skin, eyes, urinary tract, respiratory tract, and diseases of the nervous system."} -{"_id": 5558, "text": "A Chromadorea infectious disease that involves infection by parasitic nematodes of the order Oxyurida."} -{"_id": 5561, "text": "An inherited metabolic disorder characterized by the body's inability to break down proteins and fats to produce energy. It is a disorder of fatty acid,amino acid, and choline metabolism and has an autosomal recessive inheritance pattern. It is caused by mutations in the ETFA, ETFB and ETFDH genes. It presents three clinical phenotypes: a neonatal-onset form with congenital anomalies (type I), a neonatal-onset form without congenital anomalies (type II), and a late-onset form (type III). The neonatal-onset forms are usually fatal."} -{"_id": 5564, "text": "A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has_symptom stiff body, has_symptom muscle spasms, has_symptom difficulty in breathing, and has_symptom exhaustion."} -{"_id": 5567, "text": "A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery."} -{"_id": 5570, "text": "A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions."} -{"_id": 5573, "text": "A urinary bladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 5576, "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue."} -{"_id": 5579, "text": "An embryonal rhabdomyosarcoma located in the parameningeal region."} -{"_id": 5582, "text": "A Charcot-Marie-Tooth disease has_material_basis_in X-linked inheritance of a point mutation in the connexin-32 gene."} -{"_id": 5585, "text": "An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe."} -{"_id": 5588, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys."} -{"_id": 5591, "text": "An idiopathic generalized epilepsy that is characterized by febrile seizures often with accessory afebrile generalized tonic-clonic seizures with childhood onset."} -{"_id": 5594, "text": "A candidiasis that involves fungal infection of the esophagus by Candida albicans in immunocompromised people, resulting in lesions, bleeding, painful swallowing and substernal pain."} -{"_id": 5597, "text": "A Cytomegalovirus infectious disease that results_in infection, located_in colon, has_material_basis_in Human herpesvirus 5, which results_in_formation_of ulcer, has_symptom watery or bloody diarrhea, has_symptom abdominal pain, has_symptom fever, and has_symptom weight loss."} -{"_id": 5600, "text": "A pancreatic carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 5603, "text": "An Epstein-Barr virus infectious disease and is_a carcinoma that derives_from epithelial cells, has_material_basis_in Human herpesvirus 4, which causes a growth activation of the epithelial cells that it infects."} -{"_id": 5606, "text": "A suppurative otitis media with sudden onset and a short course."} -{"_id": 5609, "text": "A dissociative disorder where he continuity of the patient's memory is disrupted. Patients with dissociative amnesia have recurrent episodes in which they forget important personal information or events, usually connected with trauma or severe stress."} -{"_id": 5612, "text": "A disease of mental health that involves the impairment in normal sexual functioning."} -{"_id": 5615, "text": "A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm."} -{"_id": 5618, "text": "An angiostrongyliasis that involves infection of the intestine by Angiostrongylus costaricensis, which is characterized by the formation of granulomas with heavy eosinophilic infiltration in the abdominal cavity."} -{"_id": 5621, "text": "An endometrial carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 5624, "text": "An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot."} -{"_id": 5627, "text": "An adnexa disease that is located_in the eye socket."} -{"_id": 5630, "text": "An acrocephalosyndactylia that has_material_basis_in a genetic mutation in the TWIST1 gene which results_in premature fusion located_in skull."} -{"_id": 5633, "text": "A syphilis that is characterized as the second stage of syphilis which appears from 2 to 6 months after primary infection, and is marked by lesions especially in the skin but also in organs and tissues, and that lasts from 3 to 12 weeks."} -{"_id": 5636, "text": "A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure."} -{"_id": 5639, "text": "A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils."} -{"_id": 5642, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma."} -{"_id": 5645, "text": "A lice infestation that involves parasitic infestation by pubic lice Pthirus pubis, which are found in the pubic hair, less commonly in eyebrows, eyelashes, beard, mustache, armpit, perianal area, groin, trunk and scalp. The symptoms include itching in the pubic and groin area. Intense itching leads to scratching which can cause sores and secondary bacterial infection of the skin."} -{"_id": 5648, "text": "A disorder that has an available objective mechanical test (such as chemical tests or brain scans), and are diagnosed only by behavioral syndrome (such as those in the Diagnostic and Statistical Manual of Mental Disorders (DSM)."} -{"_id": 5651, "text": "An encephalomyelitis characterized by inflammation located_in brain and located_in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection."} -{"_id": 5654, "text": "A type of ALS with juvenile onset caused_by mutation located_in HNRNPA1 gene located_in chromosome 12."} -{"_id": 5657, "text": "A Haemophilus influenzae infectious disease that is caused by the strains of Haemophilus influenzae resulting in pleural effusions. This disease occurs in individuals with disorders that impaired the normal defense mechanisms and with pre-existing lung disease. H. influenzae causes bronchopneumonia making the patients wheezy and progressively more breathless."} -{"_id": 5660, "text": "A trypanosomiasis that is a chronic, sexually transmitted disease of horses and other equids, caused by the protozoan parasite Trypanosoma equiperdum, which is characterized by swelling of the genitalia, cutaneous plaques and neurological signs."} -{"_id": 5663, "text": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia."} -{"_id": 5666, "text": "A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye."} -{"_id": 5669, "text": "A Simplexvirus infectious disease that results_in inflammation located_in mucosa of mouth, has_material_basis_in Human herpesvirus 1, and has_symptom cold sores, has_symptom bad breath, and has_symptom fever."} -{"_id": 5672, "text": "An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories."} -{"_id": 5675, "text": "A color blindness that is characterised by a selective deficiency of blue vision, has_material_basis_in autosomal dominant inheritance of a mutation in the OPN1SW gene and is associated with a deficiency or absence of blue-sensitive cone photoreceptor function."} -{"_id": 5678, "text": "A Reoviridae infectious disease that results_in infection in vertebrates, has_material_basis_in Orbivirus, which is transmitted_by mosquitoes, transmitted_by midges, transmitted_by gnats, transmitted_by sandflies, and transmitted_by ticks."} -{"_id": 5681, "text": "An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy."} -{"_id": 5684, "text": "A tracheal disease which involves bacterial infection of the trachea often caused by Staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. The symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions."} -{"_id": 5687, "text": "A non-Hodgkin lymphoma that has_material_basis_in B cells."} -{"_id": 5690, "text": "An agnosia that is a loss of the ability to distinguish visual shapes."} -{"_id": 5693, "text": "A renal infectious disease and is_a Human immunodeficiency virus infectious disease that results_in infection located_in kidney, has_material_basis_in has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom nephrotic-range proteinuria (>3.5 g/d), has_symptom azotemia, has_symptom hypoalbuminemia, and has_symptom hyperlipidemia."} -{"_id": 5696, "text": "A brain cancer that is located_in the infratentorial region."} -{"_id": 5699, "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in cervix, has_material_basis_in human papillomavirus (types 16 or 18), which cause malignant tumors in squamous epithelium of cervix."} -{"_id": 5702, "text": "A Bartholin's gland carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 5705, "text": "An autosomal recessive disease that is characterized by inverted facial expressions in association with a severe and early-onset form of dysfunctional urinary voiding."} -{"_id": 5708, "text": "A X-linked hereditary ataxia that is characterized by adult-onset progressive intention tremor and gait ataxia, has_material_basis_in expanded trinucleotide repeat of the FMR1 gene that results_in a toxic gain of function of FMR1 RNA."} -{"_id": 5711, "text": "An atrioventricular block characterized by the presence of conduction system disease of any form, which is diagnosed on or before 28 days of life."} -{"_id": 5714, "text": "An autosomal dominant disease characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis."} -{"_id": 5717, "text": "An ehrlichiosis that results_in infection located_in monocyte or located_in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash."} -{"_id": 5720, "text": "An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as \\sore throat\\\". The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.\""} -{"_id": 5723, "text": "An endocardium disease that is characterized by a thickening of the inmost lining of the heart chambers due to an increase in the amount of supporting connective tissue and elastic fibers."} -{"_id": 5726, "text": "A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales."} -{"_id": 5729, "text": "A heart valve disease that is characterized by repeated inflammation with fibrinous repair. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.It is caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage."} -{"_id": 5732, "text": "An amyloidosis that is characterized by a loss of sensation in the extremities, cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis resulting from abnormal deposits of amyloid protein in the body's organs and tissues and has_material_basis_in autosomal dominant inheritance of mutations in the TTR gene."} -{"_id": 5735, "text": "An integumentary system disease that is located_in nail."} -{"_id": 5738, "text": "A viral infectious disease that affects CD8 lymphocytes, has_material_basis_in Human T-lymphotropic virus 2, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The person infected with HTLV-2 develop neurologic diseases resembling tropical spastic paraparesis."} -{"_id": 5741, "text": "A germ cell cancer that lacks histologic differentiation. It usually refers to a tumor in the brain."} -{"_id": 5744, "text": "An ovary serous adenocarcinoma that has_material_basis_in glandular epithelium, in which cystic accumulations of retained secretions are formed."} -{"_id": 5747, "text": "A carcinoma in situ that is characterized by the spread of cancer in the respiratory system and the lack of invasion of surrounding tissues."} -{"_id": 5750, "text": "A gastroenteritis that involves inflammation of the stomach and intestines caused by viruses. The symptoms include abdominal cramps and pain, fever, watery diarrhea, loss of appetite, nausea, and vomiting."} -{"_id": 5753, "text": "A multiple myeloma that is a slow growing type of myeloma in which abnormal plasma cells results_in too much of a single type of monoclonal antibody."} -{"_id": 5756, "text": "An embryonal testis carcinoma that is located within a tubule."} -{"_id": 5759, "text": "An adenosarcoma and malignant ovarian endometroid tumorthat is located_in the ovary."} -{"_id": 5762, "text": "A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling."} -{"_id": 5765, "text": "A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods."} -{"_id": 5768, "text": "A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread."} -{"_id": 5771, "text": "A parasitic helminthiasis infectious disease that involves zoonotic infection caused by Moniezia expansa, the common tapeworm of sheep."} -{"_id": 5774, "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine in pigs, has_material_basis_in Transmissible gastroenteritis virus, which is transmitted_by ingestion of food contaminated with feces. The infection has_symptom vomiting, has_symptom watery yellow diarrhea, has_symptom weight loss, and has_symptom dehydration."} -{"_id": 5777, "text": "An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage."} -{"_id": 5780, "text": "A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern."} -{"_id": 5783, "text": "A bone structure disease characterized by an appreciable lateral deviation in the normally straight vertical line of the spine."} -{"_id": 5786, "text": "An oral cavity cancer that is located_in the salivary gland."} -{"_id": 5789, "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Sapovirus, which is transmitted_by ingestion of contaminated food. The infection has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, and has_symptom diarrhea."} -{"_id": 5792, "text": "A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate."} -{"_id": 5795, "text": "An autosomal dominant disease characterized by the higher than normal tendency to develop breast and ovarian cancers in genetically related families."} -{"_id": 5798, "text": "A maxillary sinusitis which lasts for 12 weeks or more."} -{"_id": 5801, "text": "An anal canal cancer that derives_from epithelial squamous cells."} -{"_id": 5804, "text": "A uterine cancer that is located_in the uterine corpus."} -{"_id": 5807, "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract."} -{"_id": 5810, "text": "A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause."} -{"_id": 5813, "text": "An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body."} -{"_id": 5816, "text": "A ciliopathy that is characterized by congenital malformation of the brainstem and agenesis or hypoplasia of the cerebellar vermis leading to an abnormal respiratory pattern, nystagmus, hypotonia, ataxia, and delay in achieving motor milestones."} -{"_id": 5819, "text": "A secondary syphilis that involves infection of the liver by the spirochete Treponema pallidum, which results in the formation of hepatic lesions."} -{"_id": 5822, "text": "An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures."} -{"_id": 5825, "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Norovirus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by fomites. The infection has_symptom vomiting, has_symptom watery diarrhea, has_symptom abdominal cramps, has_symptom nausea, and has_symptom fever."} -{"_id": 5828, "text": "A sphenoid sinusitis which lasts for 12 weeks or more."} -{"_id": 5831, "text": "A recurrent hematologic cancer that is located_in bone marrow and is characterized by the production of too many lymphocytes."} -{"_id": 5834, "text": "An opportunistic mycosis that results_in fungal infection located_in cutaneous tissues or located_in subcutaneous tissues followed by a traumatic implantation of fungal elements through the skin, has_material_basis_in Mucorales molds and has_symptom necrotic lesions which progressively evolve from the epidermis into dermis and even muscle."} -{"_id": 5837, "text": "An osteochondrodysplasia characterized by short stature, joint laxity, scoliosis, and advanced carpal ossification with a delta phalanx."} -{"_id": 5840, "text": "A lymphoma by site that is manifested in immune system cells called lymphocytes."} -{"_id": 5843, "text": "A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 5846, "text": "A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph."} -{"_id": 5849, "text": "A brucellosis involving an infection caused by Brucella canis in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly."} -{"_id": 5852, "text": "A bronchus cancer that has_material_basis_in squamous cells, mucus-secreting cells, and intermediate cells."} -{"_id": 5855, "text": "A diphtheria that is characterized by a mucopurulent nasal discharge (containing both mucus and pus) which may become blood-tinged. A white membrane usually forms on the nasal septum. The disease is usually fairly mild because of apparent poor systemic absorption of toxin in this location, and it can be terminated rapidly by antitoxin and antibiotic therapy."} -{"_id": 5858, "text": "A primary Bacillaceae infectious disease that is caused by ingestion of food contaminated with Bacillus cereus, which produces enterotoxins in the intestine. The symptoms include vomiting, abdominal cramps, fever and diarrhea."} -{"_id": 5861, "text": "An adrenal gland cancer that derives_from immature neuroblastic cells."} -{"_id": 5864, "text": "A muscle cancer that is located_in striated muscle and has_material_basis_in rhabdoid cells which are large cells with eccentrically located nuclei and abundant, eosinophilic cytoplasm."} -{"_id": 5867, "text": "A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone\\ and symptoms starting before seven years of age.\""} -{"_id": 5870, "text": "An extrapulmonary tuberculosis that is located_in urogenital system."} -{"_id": 5873, "text": "A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules."} -{"_id": 5876, "text": "An endocrine gland cancer located_in the adrenal glands which are located above the kidneys."} -{"_id": 5879, "text": "A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue."} -{"_id": 5882, "text": "An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii."} -{"_id": 5885, "text": "A nasal cavity carcinoma that has_material_basis_in squamous cells."} -{"_id": 5888, "text": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint."} -{"_id": 5891, "text": "A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis."} -{"_id": 5894, "text": "An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia."} -{"_id": 5897, "text": "An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63."} -{"_id": 5900, "text": "A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms."} -{"_id": 5903, "text": "A glycogen metabolism disorder that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types."} -{"_id": 5906, "text": "An adamantinoma of long bone that is located_in the tibia."} -{"_id": 5909, "text": "A carcinoma that is characterized by a BRD4-NUT translocation involving the rearrangement of the bromodomain-containing protein 4 (BRD4) and the gene encoding nuclear protein of the testis (NUT) at 15q14, BRD4-NUT t(15;19)(q14;q13.1) and arises from midline epithelial structures, most commonly the head, neck, and mediastinum."} -{"_id": 5912, "text": "A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer."} -{"_id": 5915, "text": "A rhabdomyosarcoma and sarcoma of prostate that is located_in the prostate."} -{"_id": 5918, "text": "A fallopian tube cancer that is located_in the fallopian tube."} -{"_id": 5921, "text": "An agnosia that is a loss of the ability to perceive any auditory information but whose hearing is intact."} -{"_id": 5924, "text": "An ectothrix infectious disease that results_in anthropophilic fungal infection located_in scalp and located_in hair, has_material_basis_in Trichophyton megninii."} -{"_id": 5927, "text": "A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant."} -{"_id": 5930, "text": "An autosomal dominant disease characterized by increases risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata."} -{"_id": 5933, "text": "A embryonal cancer that is located in the kidney."} -{"_id": 5936, "text": "A mansonelliasis that involves parasitic infection by the nematode Mansonella perstans, which resides in body cavities and the surrounding tissues causing angioedema, pruritus, fever, headaches, arthralgias, and neurologic manifestations. Midges transmit the disease."} -{"_id": 5939, "text": "A pancreas adenocarcinoma that derives_from pancreatic duct cells."} -{"_id": 5942, "text": "A hematologic cancer that is located_in the blood or bone marrow that doesn't respond to treatment."} -{"_id": 5945, "text": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."} -{"_id": 5948, "text": "A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever."} -{"_id": 5951, "text": "A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress."} -{"_id": 5954, "text": "A dermatitis that selectively affects the hands and feet."} -{"_id": 5957, "text": "An autosomal dominant disease that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene)."} -{"_id": 5960, "text": "A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system."} -{"_id": 5963, "text": "An ancylostomiasis that involves infection of the intestine in dogs and humans by the nematode Ancylostoma caninum. In humans, the larvae migrate to the intestine causing eosinophilic enteritis. They have also been implicated as a cause of diffuse unilateral subacute neuroretinitis."} -{"_id": 5966, "text": "A syndrome that is acterized by a pattern of congenital anomalies including choanal atresia and malformations of the heart, inner ear, and retina."} -{"_id": 5969, "text": "A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body."} -{"_id": 5972, "text": "A non-Hodgkin lymphoma that is characterized as an indolent non-Hodgkin's lymphoma and has_material_basis_in follicle center B-cells (centrocytes and centroblasts)."} -{"_id": 5975, "text": "A viral infectious disease that results_in bronchioloalveolar carcinoma in ovine, located_in lung, has_material_basis_in Jaagsiekte sheep retrovirus, characterized by proliferation of the pulmonary alveolar epithelium and occlusion of the alveoli and terminal bronchioles, presenting as a collection of benign growths of grandular origin."} -{"_id": 5978, "text": "A syndrome that results_in rheumatoid arthritis, splenomegaly and neutropenia."} -{"_id": 5981, "text": "An autosomal dominant cerebellar ataxia that is characterized by the early-onset of cerebellar signs and eye movement abnormalities with a very slow disease progression, and has_physical_basis_in a mutation in the SPTBN2 gene."} -{"_id": 5984, "text": "An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone."} -{"_id": 5987, "text": "An anthrax disease that results_in infection located_in skin, has_material_basis_in Bacillus anthracis, which is transmitted_by contact with infected animals or animal products. The infection has_symptom skin lesion that eventually forms an ulcer with a black center."} -{"_id": 5990, "text": "A Picornaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Cardiovirus."} -{"_id": 5993, "text": "A colitis caused_by inadequate blood supply to the colon."} -{"_id": 5996, "text": "A Simplexvirus infectious disease that results_in infection located_in brain, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2. The infection has_symptom headache, has_symptom fever, has_symptom personality and behavioral changes, has_symptom seizures, has_symptom partial paralysis, and has_symptom hallucinations."} -{"_id": 5999, "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain."} -{"_id": 6002, "text": "A mitral valve disease where one or both of the cusps of the mitral valve bulge or collapse backward in the left atrium during systole."} -{"_id": 6005, "text": "A bubonic plague that results_in a benign form of bubonic plague, has_symptom fever, has_symptom lymphadenitis, has_symptom headache and has_symptom prostration."} -{"_id": 6008, "text": "A middle ear carcinoma that has_material_basis_in squamous cells."} -{"_id": 6011, "text": "An opportunistic bacterial infectious disease that involves infection of the intestine caused by Morganella morganii."} -{"_id": 6014, "text": "A staphylococcal infectious disease that involves infection of the intestine caused by staphylococci, which produce toxins. The symptoms include diarrhea, abdominal pain, vomiting and nausea."} -{"_id": 6017, "text": "A combined T cell and B cell immunodeficiency that is caused by mutation in TNFRSF5 resulting in type 3 hyper-IgM immunodeficiency characterized by an inability of B cells to undergo isotype switching, an inability to mount an antibody-specific immune response, and a lack of germinal center formation."} -{"_id": 6020, "text": "A cell type benign neoplasm that from perivascular epithelioid cells."} -{"_id": 6023, "text": "An autosomal dominant disease characterized by short stature, moderate to sever intellectual disability, distinctive facial features and broad thumbs and first toes; additionally it can include eye abnormalities, heart and kidney defects, dental problems and obesity."} -{"_id": 6026, "text": "A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm."} -{"_id": 6029, "text": "A severe pre-eclampsia characterized by hemolysis, elevated liver enzyme and low platelet count."} -{"_id": 6032, "text": "A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8)."} -{"_id": 6035, "text": "A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones."} -{"_id": 6038, "text": "A personality disorder that is characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, emotional coldness and sometimes sexual apathy, with a simultaneous rich, elaborate and exclusively internal fantasy world."} -{"_id": 6041, "text": "A syndrome characterized by mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma. It is cause by homozygous mutation in the AP1S1 gene on chromosome 7q22."} -{"_id": 6044, "text": "A otitis media which involves transudation of fluid in the middle ear without pus formation."} -{"_id": 6047, "text": "An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods."} -{"_id": 6050, "text": "An endometrial carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 6053, "text": "A vulva cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 6056, "text": "A Varicellovirus infectious disease that results_in inflammation located_in meninges, has_material_basis_in Human herpesvirus 3, which reactivates after the primary infection. The infection has_symptom fever, has_symptom headache, has_symptom cervical rigidity, has_symptom seizure, has_symptom ataxia, and has_symptom skin lesions."} -{"_id": 6059, "text": "A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma."} -{"_id": 6062, "text": "A candidiasis that involves fungal infection of the outer ear canal caused by Candida species. The symptoms include discharge, tinnitus, pruritus, and a feeling of fullness in the ear resulting in scratching and further damage to the epidermis."} -{"_id": 6065, "text": "A spinal cancer that is located_in the spinal cord and has_material_basis_in glial cells."} -{"_id": 6068, "text": "A somatoform disorder that involves an excessive preoccupation or worry about having a serious illness."} -{"_id": 6071, "text": "A lipodystrophy characterized by abnormal subcutaneous adipose tissue distribution beginning in late childhood or early adult life."} -{"_id": 6074, "text": "A hepatobiliary benign neoplasm located_in the biliary tract."} -{"_id": 6077, "text": "A myopathy that is characterized by mitochondrial dysfunction."} -{"_id": 6080, "text": "A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea."} -{"_id": 6083, "text": "A basal ganglia disease characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language."} -{"_id": 6086, "text": "A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood."} -{"_id": 6089, "text": "A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells."} -{"_id": 6092, "text": "A malignant neoplasm that is manifested in the lower limb."} -{"_id": 6095, "text": "A RNA virus infectious disease that results_in infection, has_material_basis_in dsRNA viruses, which possess double-stranded RNA genomes."} -{"_id": 6098, "text": "A crustacean allergy triggered by Penaeus monodon."} -{"_id": 6101, "text": "A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly."} -{"_id": 6104, "text": "A cell type benign neoplasm that has_material_basis_in glial cells."} -{"_id": 6107, "text": "An intestinal disease that involves inflammation located_in intestine."} -{"_id": 6110, "text": "A chromosomal deletion syndrome that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes."} -{"_id": 6113, "text": "A Chromadorea infectious disease that involves infection of humans and domestic animals by parasitic roundworms with three lips on the anteriour end."} -{"_id": 6116, "text": "A human papilloma virus related cervical squamous cell carcinoma that results_in infection located_in cervix, has_material_basis_in human papillomavirus (types 16 or 18), which cause warty malignant tumors in squamous epithelium of cervix."} -{"_id": 6119, "text": "A rheumatic disease and collagen disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs."} -{"_id": 6122, "text": "A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems."} -{"_id": 6125, "text": "A biliary tract cancer that is located_in the gallbladder."} -{"_id": 6128, "text": "A neuromuscular disease characterized by congenital weakness, arthrogryposis, cleft palate, ptosis, myopathic facies, short stature, kykphoscoliosis, talipes deformities and susceptibility to malignant hyperthermia provoked by anesthesia; caused by homozygous mutation in the STAC3 gene on chromosome 12q13."} -{"_id": 6131, "text": "An adenovirus infectious disease that results_in inflammation located_in brain, has_material_basis_in Human adenovirus 2 or has_material_basis_in Human adenovirus 4. The symptoms include fever, stupor, nuchal rigidity, loss of consciousness and seizures."} -{"_id": 6134, "text": "An appendix cancer that is characterized by progressive accumulation of mucus-secreting tumor cells within the abdomen and pelvis."} -{"_id": 6137, "text": "An agnosia that is a loss of the ability to visually recognise an object while maintaining the use of non-visual sensory systems such as feeling, tapping, smelling, rocking or flicking the object to recognise the object."} -{"_id": 6140, "text": "A benign neoplasm that is classified by the organ system from which it is arising from."} -{"_id": 6143, "text": "A primary Helicobacter infectious disease that involves inflammation of the stomach lining caused by Candidatus Helicobacter heilmannii, which is associated with peptic ulceration."} -{"_id": 6146, "text": "An angiosarcoma and gallbladder sarcoma that is located_in the gallbladder."} -{"_id": 6149, "text": "A Reoviridae infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Rotavirus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by fomites. The infection has_symptom fever, has_symptom vomiting, has_symptom diarrhea, and has_symptom abdominal pain."} -{"_id": 6152, "text": "A severe combined immunodeficiency that results from defective IL7R expression causes T-B+NK+ SCID. Loss of IL-7R function leads to the loss of an antiapoptotic signal, resulting in a loss of T-cell selection in thymus."} -{"_id": 6155, "text": "A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness."} -{"_id": 6158, "text": "A metaphyseal dysplasia that has_material_basis_in mutation in PTH receptor which results_in short-limbed dwarfism."} -{"_id": 6161, "text": "A Parkinson's disease caused by mutations in the PINK1 gene located on chromosome 1p36.12."} -{"_id": 6164, "text": "An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies."} -{"_id": 6167, "text": "An osteosclerosis that has_material_basis_in a mutation of the LEMD3 gene which results_in a hyperdense bony cortex."} -{"_id": 6170, "text": "An intestinal benign neoplasm that has_material_basis_in epithelial tissue with glandular origin and is located_in the large intestine."} -{"_id": 6173, "text": "A bone structure disease that has_material_basis_in an abnormal curvature located_in vertebral column."} -{"_id": 6176, "text": "A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash."} -{"_id": 6179, "text": "A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions."} -{"_id": 6182, "text": "A acute laryngitis which is caused by viral infection."} -{"_id": 6185, "text": "A colonic benign neoplasm that has_material_basis_in epithelial tissue with glandular origin."} -{"_id": 6188, "text": "A fish allergy triggered by Gadus morhua."} -{"_id": 6191, "text": "A schistosomiasis that involves parasitic infection of the brain and spinal cord by Schistosoma haematobium, Schistosoma mansoni or Schistosoma japonicum causing acute or subacute myelopathy, focal central nervous system impairment, seizures and increased intracranial pressure."} -{"_id": 6194, "text": "An opportunistic mycosis that has_material_basis_in Pneumocystis jirovecii, located_in lymph node, located_in spleen, located_in liver and located_in bone marrow, results_in_formation_of lesions."} -{"_id": 6197, "text": "A small intestine cancer that is located_in the beginning section of the small intestine."} -{"_id": 6200, "text": "A acute sanguinous otitis media caused by an allergen."} -{"_id": 6203, "text": "A acute transudative otitis media which involves bloody effusion."} -{"_id": 6206, "text": "An alveolar soft part sarcoma and cervical soft tissue tumor and malignant neoplasm of cervix uteri that is located_in the cervix."} -{"_id": 6209, "text": "A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet."} -{"_id": 6212, "text": "A otomycosis which is persistent and long-lasting or recurrent."} -{"_id": 6215, "text": "A hypogonadism that is characterized by the lack of mature male germ cells and testicular hormones."} -{"_id": 6218, "text": "A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy."} -{"_id": 6221, "text": "An ectothrix infectious disease that results_in geophilic and zoophilic fungal infection located_in skin, located_in scalp and located_in hair, has_material_basis_in Microsporum nanum, which results_in_formation_of chronic non-inflammatory lesions in pigs and humans."} -{"_id": 6224, "text": "A cholesteatoma which involves invasion of the squamous tissue into a localized area of bony erosion of the ear canal. It may develop spontaneously or as a consequence of infection, trauma or surgery."} -{"_id": 6227, "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the urinary bladder caused by Trichomonas vaginalis. The symptoms include pain during urination, foul urine odor and abnormal urine color."} -{"_id": 6230, "text": "A idiopathic interstitial pneumonia which develops suddenly and is severe. Initially, the lung shows edema, hyaline membranes, and interstitial acute inflammation. Later,it develops loose organizing fibrosis, mostly within alveolar septa and type II pneumocyte hyperplasia. Fever, cough, and difficulty breathing develop over 1 to 2 weeks, typically progressing to acute respiratory failure."} -{"_id": 6233, "text": "An agnosia that is a loss of the ability to comprehending the meaning of written words."} -{"_id": 6236, "text": "A capillariasis that involves infection of the intestine with Capillaria causing abdominal pain, weight loss, stomach growling, depressed levels of potassium and albumin in the blood, and diarrhea."} -{"_id": 6239, "text": "A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability."} -{"_id": 6242, "text": "A carcinoma that is an early development defined by the absence of invasion of surrounding tissues."} -{"_id": 6245, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Fasciolopsis buski. The symptoms include diarrhea, abdominal pain, fever, ascites, anasarca and intestinal obstruction."} -{"_id": 6248, "text": "A syndrome characterized by exocrine pancreatic insufficiency, bone marrow failure and skeletal abnormalities."} -{"_id": 6251, "text": "A laryngeal carcinoma that has_material_basis_in squamous cells."} -{"_id": 6254, "text": "An epilepsy syndrome that is located_in an area of the brain other than the temporal lobe."} -{"_id": 6257, "text": "A acute transudative otitis media with thin, watery and sterile effusion."} -{"_id": 6260, "text": "An osteochondrodysplasia that results_in abnormalities of bone growth located_in vertebral column, located_in epiphysis, located_in metaphysis."} -{"_id": 6263, "text": "A monogenic disease that is characterized by glomerulonephritis, endstage kidney disease, and hearing loss."} -{"_id": 6266, "text": "A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart."} -{"_id": 6269, "text": "A fruit allergy triggered by Prunus avium plant fruit food product."} -{"_id": 6272, "text": "A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol."} -{"_id": 6275, "text": "A viral infectious disease that results_in infection located in skin of mice, has_material_basis_in Ectromelia virus. The infection has_symptom swelling of the feet, has_symptom gangrene, and has_symptom lesions on the skin."} -{"_id": 6278, "text": "A thyroid carcinoma that has_material_basis_in follicular cells."} -{"_id": 6281, "text": "A vascular cancer that is characterized by an encapsulated, firm round mass at the bifurcation of the common carotid artery."} -{"_id": 6284, "text": "A respiratory system disease which involves the lower respiratory tract."} -{"_id": 6287, "text": "A childhood renal Wilms cancer that occurs in children. It encompasses two histologically distinct but grossly indistinguishable lesions: cystic nephroma and cystic partially differentiated nephroblastoma (CPDN)."} -{"_id": 6290, "text": "Alpha thalassemia is a thalassemia involving the genes HBA1and HBA2 hemoglobin genes."} -{"_id": 6293, "text": "A hypothyroidism that is present at birth."} -{"_id": 6296, "text": "A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision."} -{"_id": 6299, "text": "An autosomal recessive disease that is characterized by the buildup of thick, sticky mucus that can damage many organs."} -{"_id": 6302, "text": "An angiosarcoma and sarcoma of the mediastinum that is located_in the mediastinum."} -{"_id": 6305, "text": "A substance dependence that involves the continued use of drugs despite problems related to use of the substance."} -{"_id": 6308, "text": "A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia."} -{"_id": 6311, "text": "A cholangitis that is characterized_by an inflammation that is located_in the gallbladder."} -{"_id": 6314, "text": "An agnosia that is a loss of the ability to comprehend the succession and duration of events."} -{"_id": 6317, "text": "A hematologic cancer located_in the central nervous system."} -{"_id": 6320, "text": "An aspergillosis that involves an allergic reaction due to the spores of Aspergillus moulds (A. fumigatus), which colonizes the mucus in the airways causing inflammation. The disease has_symptom cough, has_symptom wheezing and has_symptom fever."} -{"_id": 6323, "text": "An inherited metabolic disorder that involves peroxisome malfunction."} -{"_id": 6326, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears."} -{"_id": 6329, "text": "A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart."} -{"_id": 6332, "text": "A diphtheria that involves a bluish white membrane formation on the larynx. It can be an extension of the nasopharyngeal diphtheria. This membrane can lead to airway obstruction, coma, and death. Symptoms include fever, hoarseness, and a barking cough."} -{"_id": 6335, "text": "A tonsil cancer that has_material_basis_in squamous cells."} -{"_id": 6338, "text": "A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen."} -{"_id": 6341, "text": "An acquired metabolic disease that involves abnormal deposited of amyloid proteins in organs and/or tissues."} -{"_id": 6344, "text": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness."} -{"_id": 6347, "text": "A dental enamel hypoplasia characterized by abnormal enamel formation."} -{"_id": 6350, "text": "A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin without elevation of liver alanine transaminase and aspartate transaminase enzymes as a result of the deficient ability of hepatocytes to secrete conjugated bilirubin into the bile."} -{"_id": 6353, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Nipah virus, which is transmitted_by direct contact with sick person or animals, or their contaminated tissues. The infection has_symptom dizziness, has_symptom drowsiness, has_symptom altered consciousness, has_symptom disorientation, and has_symptom coma."} -{"_id": 6356, "text": "An Ehlers-Danlos syndrome that is characterized by aged appearance, developmental delay, short stature, craniofacial disproportion, generalized osteopenia, defective wound healing, hypermobile joints, hypotonic muscles, and loose but elastic skin and has_material_basis_in compound heterozygous mutation in the B3GALT6 gene."} -{"_id": 6359, "text": "A pseudohermaphroditism that is characterized by the persistence of Mullerian duct derivatives (i.e. uterus, cervix, fallopian tubes and upper two thirds of vagina) in a phenotypically and karyotypically male."} -{"_id": 6362, "text": "A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts."} -{"_id": 6365, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma."} -{"_id": 6368, "text": "A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus."} -{"_id": 6371, "text": "A vaginitis that is characterized by a grayish vaginal discharge usually of foul odor and the presence of Gardnerella vaginalis."} -{"_id": 6374, "text": "A neurodegenerative disease characterized by spastic paraplegia, axonal neuropathy, dysarthria, acoustic startle, and congenital optical atrophy. It is caused by homozygous mutation in the KLC2 gene on chromosome 11q13.2."} -{"_id": 6377, "text": "An upper respiratory tract disease characterized by the swelling of the uvula to 3-5 times its normal size."} -{"_id": 6380, "text": "A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms."} -{"_id": 6383, "text": "A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint."} -{"_id": 6386, "text": "An autosomal recessive disease characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers. In 90% of the cases it is caused by mutations in the WRN gene, located_in chromosome 8."} -{"_id": 6389, "text": "An integumentary system disease that is located_in skin."} -{"_id": 6392, "text": "A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors."} -{"_id": 6395, "text": "A stage 0 cancer of the testis consisting of the uniform precursor of testicular germ cell tumors (GCTs). ITGCNU can be found in testicular tissue adjacent to GCTs in approximately 90 percent of adult cases and is found in all groups at risk for testicular cancer, including men with cryptorchid testes, prior testicular cancer, and individuals with abnormal sexual differentiation."} -{"_id": 6398, "text": "A schistosomiasis that involves parasitic infection of domestic animals by Schistosoma mattheei."} -{"_id": 6401, "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine of sheep and goats, has_material_basis_in Nairobi sheep disease virus, which is transmitted_by Rhipicephalus appendiculatus ticks. The infection has_symptom fever, has_symptom leukopenia, has_symptom rapid respiration, has_symptom anorexia, has_symptom profound depression, has_symptom diarrhea, and has_symptom dehydration."} -{"_id": 6404, "text": "A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma."} -{"_id": 6407, "text": "An amino acid metabolic disorder that involves the accumulation of argininosuccinic acid (ASA) in the blood and urine."} -{"_id": 6410, "text": "A renal tubular transport disease of the proximal renal tubes characterized by glucosuria, phosphaturia, generalized aminoaciduria and HCO3 wasting."} -{"_id": 6413, "text": "A tonsillitis which involves collection of pus beside the tonsil (peritonsillar space). It is caused by both aerobic and anaerobic bacteria. Commonly involved species include streptococci, staphylococci and hemophilus. Progressively worsening unilateral sore throat and pain during swallowing usually are the earliest symptoms. As the abscess develops, persistent pain in the peritonsillar area, fever, malaise, headache and a distortion of vowels informally known as \\hot potato voice\\\" may appear. Neck pain associated with tender, swollen lymph nodes, referred ear pain and halitosis are also common.\""} -{"_id": 6416, "text": "An alveolar soft part sarcoma that has spread to other parts of the body."} -{"_id": 6419, "text": "A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs."} -{"_id": 6422, "text": "A bone remodeling disease that results_in abnormal elevated bone density or mass."} -{"_id": 6425, "text": "A Parkinson's disease caused by homozygous or compound heterozygous mutation in the DJ1 gene on chromosome 1p36."} -{"_id": 6428, "text": "A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting."} -{"_id": 6431, "text": "A bovine respiratory disease complex defined as an acute, noncontagious respiratory distress caused 5-10days after change to a better, often lush, pasture. Metabolites of the naturally occurring amino acid L-tryptophan probably are responsible for the disease. Severely affected cattle show extensive respiratory distress with mouth breathing, extension of the tongue, and drooling. There is extensive edema and emphysema, often with the formation of large air-filled bullae in interlobular and subpleural regions of the lung."} -{"_id": 6434, "text": "A tooth disease characterized by failure to develop on or more missing teeth."} -{"_id": 6437, "text": "An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system."} -{"_id": 6440, "text": "A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus."} -{"_id": 6443, "text": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety."} -{"_id": 6446, "text": "An agnosia that is a loss of the ability to perceive and process pain."} -{"_id": 6449, "text": "A neuropathy that is located_in nerves of the peripheral nervous system."} -{"_id": 6452, "text": "A large intestine cancer that is located_in the colon and/or located_in the rectum."} -{"_id": 6455, "text": "An organ system benign neoplasm that is located_in the respiratory system which extends from the nasal sinuses to the diaphragm."} -{"_id": 6458, "text": "A cerebellar disease characterized by ataxia originating in the cerebellum."} -{"_id": 6461, "text": "An autosomal recessive disease that is characterized at birth or prenatally by malformations and deformities affecting the majority of the skeleton and other areas of the body with autosomal recessive inheritance of the FGFR2 gene."} -{"_id": 6464, "text": "A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions."} -{"_id": 6467, "text": "A histoplasmosis endocarditis that results_in inflammation located_in endocardium, has_material_basis_in Histoplasma capsulatum var duboisii or has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom murmurs, has_symptom peripheral edema, has_symptom pulmonary rales, has_symptom petechia and has_symptom skin lesions."} -{"_id": 6470, "text": "A pancreatic cancer that is located_in the pancreatic islet cells."} -{"_id": 6473, "text": "A sarcoma and malignant neoplasm of penis that is located_in the penis."} -{"_id": 6476, "text": "A commensal Clostridium infectious disease that is caused by ingestion of food contaminated with Clostridium perfringens, which produces an enterotoxin that acts on the small intestine. The symptoms include watery diarrhea, abdominal cramps, a severe decrease in blood pressure and abdominal expansion from gas."} -{"_id": 6479, "text": "A candidiasis that involves fungal infection of the meninges caused by Candida species, predominantly in low birth weight neonates with septicemia, resulting in formation of abscesses."} -{"_id": 6482, "text": "A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers."} -{"_id": 6485, "text": "A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting."} -{"_id": 6488, "text": "An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents."} -{"_id": 6491, "text": "A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis."} -{"_id": 6494, "text": "Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine."} -{"_id": 6497, "text": "An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood."} -{"_id": 6500, "text": "An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body."} -{"_id": 6503, "text": "A retinal disease that is characterized by the loss of cone cells, the photoreceptors responsible for both central and color vision."} -{"_id": 6506, "text": "A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues."} -{"_id": 6509, "text": "A tularemia that is located_in lungs. The bacteria are transmitted_by breathing dusts or aerosols containing the organisms. The infection has_symptom cough, has_symptom chest has_symptom pain, and has_symptom difficulty breathing."} -{"_id": 6512, "text": "An endocrine system disease that is located_in the pituitary gland."} -{"_id": 6515, "text": "An extrinsic allergic alveolitis caused by inhalation of antigens from thermophilic actinomycetes species growing in air conditioners and humidifiers. Fungi like Aureobasidium sp and Candida albicans that survive in the contaminated water in humidifiers and air conditioners are also known to cause the disease."} -{"_id": 6518, "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in vulva, has_material_basis_in human papillomavirus (type16 and 18), which cause malignant tumors in squamous epithelium of the vulva."} -{"_id": 6521, "text": "A fundus dystrophy that is characterized by discrete uniform white dots over the entire fundus with greatest density in the midperiphery and no macular involvement."} -{"_id": 6524, "text": "A lysosomal storage disease that involves he accumulation of glycosaminoglycans in the tissues and their excretion in the urine."} -{"_id": 6527, "text": "A colonic disease characterized by the formation and inflammation of diverticula within the colon wall."} -{"_id": 6530, "text": "An autosomal recessive disease that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair."} -{"_id": 6533, "text": "A intestinal disease characterized by the protrusion by part of the intestine though an opening in the abdominal muscles."} -{"_id": 6536, "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which have signet ring appearance."} -{"_id": 6539, "text": "A synostosis that results_in premature fusion located_in skull."} -{"_id": 6542, "text": "A dermatophytosis that results_in fungal skin infection located_in hand, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, has_symptom burning, has_symptom cracking, and has_symptom scaling."} -{"_id": 6545, "text": "A bone structure disease that has_material_basis_in displacement located_in set of vertebrae."} -{"_id": 6548, "text": "A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men."} -{"_id": 6551, "text": "A mitochondrial metabolism disease that is characterized by a deficiency of CoQ10 resulting from reduced biosynthesis."} -{"_id": 6554, "text": "A hypersensitivity reaction type I disease triggered by latex."} -{"_id": 6557, "text": "A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia."} -{"_id": 6560, "text": "A syndrome characterized by malformations of the outer, middle and inner ear and branchial and renal malformations. Mutations of the EYA1, SIX1 and SIX5 genes are associated with the syndrome."} -{"_id": 6563, "text": "A mite infestation that involves rash caused by Leptotrombidium deliense."} -{"_id": 6566, "text": "An autosomal dominant disease that is characterized by low birth weight and growth retardation, bilateral branchial clefts."} -{"_id": 6569, "text": "A Rubella virus infectious disease that results_in infection located_in joint, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom joint pains."} -{"_id": 6572, "text": "A respiratory system cancer that is located_in the lung."} -{"_id": 6575, "text": "A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people."} -{"_id": 6578, "text": "A parasitic helminthiasis infectious disease that involves infection by parasitic flatworms known as tapeworms living in the vertebrate digestive tract."} -{"_id": 6581, "text": "A viral infectious disease that results_in inflammation located_in lung, has_material_basis_in Influenza A virus, has_material_basis_in Influenza B virus, or has_material_basis_in Influenza C virus, which can directly damage the respiratory epithelium, allowing free access to invading bacteria. The mucous membranes are covered with foamy, bloody fluid from the pulmonary edema in the more acute cases. Interstitial fibrosis has been observed. The infection has_symptom cough, has_symptom pain in the chest and throughout body, has_symptom headache, has_symptom weakness, and has_symptom chills."} -{"_id": 6584, "text": "A leiomyosarcoma and sarcoma of kidney that is located_in the kidney."} -{"_id": 6587, "text": "An extrinsic allergic alveolitis which is caused by inhalation of antigens from avian excreta. The disease has_symptom abrupt onset of dyspnea, has_symptom cough, has_symptom malaise, and has_symptom fever, after exposure to antigen."} -{"_id": 6590, "text": "A perichondritis of auricle with a sudden onset and a short course."} -{"_id": 6593, "text": "A pneumothorax in which air enters into the pleural cavity."} -{"_id": 6596, "text": "A vascular disease that is characterized by generalized calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall."} -{"_id": 6599, "text": "A collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen."} -{"_id": 6602, "text": "A parasitic infectious disease that occurs when part of the body is infested with parasitic worms such as cestodes, nematodes and trematodes."} -{"_id": 6605, "text": "A papillomavirus infectious disease that results_in infection, has_material_basis_in human papillomavirus (types 16, 18, 31, 32 or 33), which cause intraepithelial lesions that may progress to carcinomas."} -{"_id": 6608, "text": "A dengue disease that results_in infection, has_material_basis_in Dengue virus with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has no manifestations of symptoms."} -{"_id": 6611, "text": "An autosomal dominant disease characterized by multiple noncancerous, tumor-like growths (hamartomas) and an increased risk of certain forms of cancer, especially breast, thyroid and endometrium. It is caused by mutations in the PTEN, SDHB, SDHD and KLLN genes."} -{"_id": 6614, "text": "An autosomal recessive disease characterized by intrauterine growth retardation and postnatal dwarfism with microcephaly and intellectual disability."} -{"_id": 6617, "text": "A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding."} -{"_id": 6620, "text": "A substance abuse that involves the recurring use of amphetamines despite negative consequences."} -{"_id": 6623, "text": "A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping."} -{"_id": 6626, "text": "An urticaria induced by sweating."} -{"_id": 6629, "text": "A Kaposi's sarcoma that derives_from the tissue that lines the lymph vessels under the skin or in mucous membranes."} -{"_id": 6632, "text": "An autosomal recessive disorder characterized by severe intrauterine and postnatal growth retardation, microcephaly, bilateral microtia and hypoplastic patellae."} -{"_id": 6635, "text": "An ornithosis involving Chlamydophila psittaci infection, contracted by inhaling dust from the feathers or the waste of infected birds. The symptoms include fever, chills, fatigue, and loss of appetite. A cough develops, which is initially dry but later brings up greenish sputum."} -{"_id": 6638, "text": "A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves."} -{"_id": 6641, "text": "An agnosia that is a loss of the ability to rely on visual cues to guide them directionally due to the inability to recognise objects."} -{"_id": 6644, "text": "A cerebrum cancer that is located_in the parietal lobe."} -{"_id": 6647, "text": "A commensal Alcaligenaceae infectious disease that is caused by the bacterium Bordetella pertussis resulting in difficulty breathing."} -{"_id": 6650, "text": "A Flavivirus infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by mosquito bites. The infection has_symptom fever, has_symptom severe headache, has_symptom back pain, has_symptom muscle ache, has_symptom nausea, and has_symptom weakness."} -{"_id": 6653, "text": "An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor."} -{"_id": 6656, "text": "An endothrix infectious disease that results_in anthropophilic fungal infection located_in skin, located_in nail, located_in beard, and located_in scalp, has_material_basis_in Trichophyton violaceum and results_in_formation_of scaling lesions. The hairs become notably fragile and break easily at the level of the scalp. The rest of the infected follicle looks like \\black dots\\\".\""} -{"_id": 6659, "text": "A parasitic protozoa infectious disease that involves infection caused by fornicates, which are unicellular flagellates with one or two karyomastigonts per cell."} -{"_id": 6662, "text": "A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Trichosporon beigelii. Infected hairs develop soft greyish-white nodules along the shaft."} -{"_id": 6665, "text": "An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism."} -{"_id": 6668, "text": "An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow."} -{"_id": 6671, "text": "A breast carcinoma that is manifested in the female breast."} -{"_id": 6674, "text": "A macrocytic anemia that is characterized by inhibition of DNA synthesis during red blood cell production."} -{"_id": 6677, "text": "A yaws that appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis."} -{"_id": 6680, "text": "A spindle intraocular melanoma that is located_in the ciliary body."} -{"_id": 6683, "text": "A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by Plasmodium species."} -{"_id": 6686, "text": "A leprosy that is an early form of the disease which causes one to a few hypopigmented or erythematous macules."} -{"_id": 6689, "text": "A mouth disease characterized by a white patch on the side of the tongue with a corrugated or hairy appearance; caused by Epstein-Barr virus."} -{"_id": 6692, "text": "A syndrome that is characterized by delayed psychomotor development, visual impairment, and short stature and has_material_basis_in homozygous mutation in the PLK4 gene."} -{"_id": 6695, "text": "A biliary tract cancer that is located_in the bile duct."} -{"_id": 6698, "text": "A urinary system disease that is located_in the lower urinary tract and is characterized by the formation of a stone."} -{"_id": 6701, "text": "An agnosia that is a loss of the ability to recognize musical notes, rhythms, and intervals."} -{"_id": 6704, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the eyes by Philophthalmus species. External ocular philophthalmiasis manifests as follicular conjunctivitis and superficial keratitis. Sub-conjunctival ocular philophthalmiasis consists of a mild edema with minimal cellular reaction."} -{"_id": 6707, "text": "A parasitic protozoa infectious disease that involves infection caused by alveolates, which are single-celled eukaryotes."} -{"_id": 6710, "text": "A skin disease characterized by skin that is loose, hanging, wrinkled and lacking in elasticity; it can also affect connective tissue in other parts of the body, including the heart, blood vessels, joints, intestines and lungs."} -{"_id": 6713, "text": "A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development."} -{"_id": 6716, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis."} -{"_id": 6719, "text": "A viral infectious disease that results_in infection in sheep and goats, has_material_basis_in Border disease virus, which is transmitted_by congenital method. The infection has_symptom abortion, has_symptom stillbirth, has_symptom hairy fleece in lambs, and has_symptom abnormal body conformation."} -{"_id": 6722, "text": "A capillariasis that involves infection of the lungs with Capillaria, resulting in fever, cough, asthma, and pneumonia."} -{"_id": 6725, "text": "An eye disease characterized by variable iris atrophy, pigmented and pedunculated nodules located_in iris and attachment of the iris to the cornea (peripheral anterior synechiae) and characterized_by glaucoma."} -{"_id": 6728, "text": "A lung disease characterized by microbial infection which causes a type of liquefactive necrosis of the pulmonary tissue and formation of cavities containing necrotic debris or fluid."} -{"_id": 6731, "text": "A mesenchymal cell neoplasm that has_material_basis_in myofibroblastic cells admixed with inflammatory cells."} -{"_id": 6734, "text": "A sarcoma and hematologic cancer that derives_from follicular lymphoma."} -{"_id": 6737, "text": "A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma."} -{"_id": 6740, "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the vagina caused by Trichomonas vaginalis. The symptoms include foul vaginal odor, burning during urination, vaginal discharge and irritation of the genital area."} -{"_id": 6743, "text": "A filariasis that involves parasitic infection by the nematodes Mansonella ozzardi or Mansonella perstans, which reside in the skin or body cavities. The nematode is transmitted through the bite of midges and blackflies."} -{"_id": 6746, "text": "A dermatomycosis that results_in fungal infection located_in hand, foot and nail of toe by Scytalidium hyalinum, resulting_in_formation_of lesions and has_symptom keratotic plantar surface."} -{"_id": 6749, "text": "A severe combined immunodeficiency that is an autosomal recessive disease with T and B lymphocyte dysfunction, due to a large deletion at one allelle and a point mutation at the other. The point mutation resulted in the alteration of intervening sequence 13 donor splice site. The population of T lymphocytes is diminished and unresponsive to mitogen stimulation. The level of B lymphocyte numbers, serum immunoglobulin decreased with age."} -{"_id": 6752, "text": "A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites."} -{"_id": 6755, "text": "A labyrinthitis which is an infectious inflammatory disease of a circumscribed area of either the vestibular or the cochlear portion of the labyrinth, or of both together. This is caused by a chronic suppurative otitis media, mastoiditis, or cholesteatoma."} -{"_id": 6758, "text": "An ancylostomiasis that involves parasitic infection of the small intestine in humans, cats and dogs by the nematode Ancylostoma duodenale. The symptoms include abdominal pain, loss of appetite, geophagy and anemia."} -{"_id": 6761, "text": "An angiostrongyliasis that involves infection of the brain by the larvae of Angiostrongylus cantonensis causing eosinophilic meningitis. The symptoms include severe headache, nausea, vomiting, neck stiffness, seizures, and neurologic abnormalities. Ocular invasion by the larvae can occur."} -{"_id": 6764, "text": "A mitochondrial metabolism disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction."} -{"_id": 6767, "text": "An urinary tract cancer that derives_from the tissues of the urethra."} -{"_id": 6770, "text": "A fruit allergy triggered by Citrus sinensis plant fruit food product."} -{"_id": 6773, "text": "Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products."} -{"_id": 6776, "text": "A cystitis characterized by a sudden onset or severe symptoms."} -{"_id": 6779, "text": "A disease of mental health that affects cognitive functions including memory processing, perception and problem solving."} -{"_id": 6782, "text": "A lymphoma that is characterized by having cellular features of both classic Hodgkin's lymphomas and large B-cell Lymphomas."} -{"_id": 6785, "text": "A benign neoplasm that is classified by the type of cell or tissue from which it is derived."} -{"_id": 6788, "text": "A histiocytosis that is characterized by clonal proliferation of Langerhans cells."} -{"_id": 6791, "text": "A gastroenteritis that involves inflammation of the stomach and intestines caused by bacteria. The symptoms include abdominal cramps and pain, diarrhea, loss of appetite, nausea, and vomiting."} -{"_id": 6794, "text": "A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing."} -{"_id": 6797, "text": "An eyelid disease that is characterized by often chronic inflammation of the eyelid, generally the part where eyelashes grow."} -{"_id": 6800, "text": "A candidiasis that involves inflammation of the lung caused by Candida species either by hematogenous dissemination or by bronchial extension in patients with oropharyngeal candidiasis. The symptoms include fever, tachypnea, dyspnea, and chest pain."} -{"_id": 6803, "text": "An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra."} -{"_id": 6806, "text": "A dysostosis that is characterized by premature joint ankylosis and has_material_basis_in autosomal dominant inhertitance."} -{"_id": 6809, "text": "An ovarian cancer that has_material_basis_in melanoctyes."} -{"_id": 6812, "text": "An adenoma that is located_in the pancreas and is characterized by overproduction of insulin."} -{"_id": 6815, "text": "A pigmentation disease characterized by lesions that initially arise as letiginous, hyperpigmented macules in a reticular pattern on the dorsal aspect of the hands and feet. Over time, lesions may spread proximally and may darken; palmoplantar pitting and dermatoglyphic disruption may also be present."} -{"_id": 6818, "text": "A viral infectious disease that results_in infection in swine, has_material_basis_in Classical swine fever virus, which is transmitted_by direct contact with oronasal secretions of the infected pig, transmitted_by ingestion of contaminated food, and transmitted_by fomites. The infection has_symptom high fever, has_symptom huddling, has_symptom weakness, has_symptom drowsiness, has_symptom anorexia, has_symptom conjunctivitis, has_symptom diarrhea, and has_symptom hemorrhages in the skin."} -{"_id": 6821, "text": "A lung combined type small cell carcinoma that has_material_basis_in epithelial tissue of glandular origin."} -{"_id": 6824, "text": "A thoracic cancer that is located_in the mediastinum."} -{"_id": 6827, "text": "A disease of anatomical entity that is located_in the immune system."} -{"_id": 6830, "text": "A viral infectious disease that results_in pain located_in trigeminal nerve, has_material_basis_in Human herpesvirus 3, which reactivates after the initial infection. The infection has_symptom facial pain."} -{"_id": 6833, "text": "A spondyloepimetaphyseal dysplasia that is characterized by short stature of prenatal onset, joint dislocations (knees, hips, radial heads), club feet, and limitation of range of motion that can involve all large joints."} -{"_id": 6836, "text": "A pancreatic carcinoma located_in the pancreatic duct."} -{"_id": 6839, "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme beta-glucuronidase resulting in the inability to degrade glucuronic acid-containing glycosaminoglycans."} -{"_id": 6842, "text": "A jejunal cancer that is located_in the jejunum and has_material_basis_in epithelial tissue that has glandular origin."} -{"_id": 6845, "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system."} -{"_id": 6848, "text": "A viral infectious disease that results_in infection, has_material_basis_in Measles virus, which is transmitted_by droplet spread, or trasnmitted_by contact of oronasal secretions from an infected person."} -{"_id": 6851, "text": "A non-Hodgkin lymphoma involving aberrant T-cells."} -{"_id": 6854, "text": "An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope."} -{"_id": 6857, "text": "A carcinoma in situ that is characterized by the spread of cancer in the eye and the lack of invasion of surrounding tissues."} -{"_id": 6860, "text": "A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition."} -{"_id": 6863, "text": "A leukemia that derives_from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers."} -{"_id": 6866, "text": "A large intestine cancer that is located_in the cecum."} -{"_id": 6869, "text": "A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness."} -{"_id": 6872, "text": "A spotted fever that has_material_basis_in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities."} -{"_id": 6875, "text": "A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen."} -{"_id": 6878, "text": "A sebaceous gland disease characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring."} -{"_id": 6881, "text": "A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone."} -{"_id": 6884, "text": "A pericardial effusion in which fluid accumulates in the pericardium (the sac in which the heart is enclosed) and the pericardial spaces fills up faster than the pericardial sac can stretch."} -{"_id": 6887, "text": "A milk allergy triggered by Bos taurus milk."} -{"_id": 6890, "text": "An ischemic bone disease that results_in necrosis located_in epiphysis."} -{"_id": 6893, "text": "A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms."} -{"_id": 6896, "text": "An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size."} -{"_id": 6899, "text": "An urogenital tuberculosis that results_in inflammtion located_in ovary."} -{"_id": 6902, "text": "A hypersensitivity reaction type II disease that is characterized by glomerulonephritis located_in kidney and hemorrhaging located_in lung."} -{"_id": 6905, "text": "A bone cancer and lymphoma by site that results_in lymphoma starting in the bone."} -{"_id": 6908, "text": "An islet cell tumor that has_material_basis_in epithelial cells."} -{"_id": 6911, "text": "A germ cell cancer that is derived_from a mixture of germs cells and embryonal cells."} -{"_id": 6914, "text": "A typhus that has_material_basis_in Rickettsia prowazekii, which is transmitted_by human body louse (Pediculus humanus corporis). The infection has_symptom high fever, has_symptom cough, has_symptom rash, has_symptom severe muscle pain, has_symptom chills, has_symptom falling blood pressure, has_symptom stupor, has_symptom sensitivity to light, and has_symptom delirium."} -{"_id": 6917, "text": "A viral infectious disease that results_in infection in ruminants, has_material_basis_in Peste-des-petits-ruminants virus, which is transmitted_by contact with oronasal and ocular secretions, urine, and feces. The infection results_in_formation_of lesions on the gums, lips and palate."} -{"_id": 6920, "text": "A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back."} -{"_id": 6923, "text": "An agnosia that is a loss of the ability to recognize visual scenes or classes of objects but retain the abilty to describe them."} -{"_id": 6926, "text": "An inherited metabolic disorders which impair the synthesis and degradation of amino acids."} -{"_id": 6929, "text": "A spastic cerebral palsy that affects all four limbs. The individuals have difficulty with walking and talking."} -{"_id": 6932, "text": "An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis."} -{"_id": 6935, "text": "A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell."} -{"_id": 6938, "text": "An esophagitis characterized by inflammation involving eosinophils located_in esophagus."} -{"_id": 6941, "text": "A Salmonella infectious disease that is caused by Gram-negative bacteria of genus Salmonella which is rare in adults, although more common in children in the tropics. This infection is complicated by suppuration with lung abscess or empyema formation."} -{"_id": 6944, "text": "An alveolar soft part sarcoma that recurs over time."} -{"_id": 6947, "text": "A peroxisomal disease that is characterized by hypotonia and seizures in the neonatal period and neurological regression in early infancy."} -{"_id": 6950, "text": "A commensal streptococcal infectious disease that is caused by group B streptococci (Streptococcus agalactiae) usually infecting neonates and the elderly."} -{"_id": 6953, "text": "A Nidovirales infectious disease that results_in infection in animals and humans, has_material_basis_in Coronaviridae viruses, which is transmitted_by droplet spread of respiratory secretions or transmitted_by ingestion of contaminated food."} -{"_id": 6956, "text": "A trichostrongyloidiasis that involves parasitic infection of the ruminant gastrointestinal tract by nematodes of the genus Ostertagia."} -{"_id": 6959, "text": "A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation."} -{"_id": 6962, "text": "A syndrome that is characterized by congenital microcephaly and chorioretinal dysplasia associated with poor vision and nystagmus and has_material_basis_in compound heterozygous mutation in the TUBGCP4 gene."} -{"_id": 6965, "text": "A cystits which involves inflammation and formation of a dense fibrous false membrane on the mucous membrane of the bladder."} -{"_id": 6968, "text": "A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow."} -{"_id": 6971, "text": "A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver."} -{"_id": 6974, "text": "An organ system cancer that is located in the peritoneum."} -{"_id": 6977, "text": "A connective tissue cancer that has_material_basis_in cells derived from transformed cells that produce cartilage."} -{"_id": 6980, "text": "A (-)ssRNA virus infectious disease that results_in infection located_in liver in humans, has_material_basis_in Deltavirus."} -{"_id": 6983, "text": "A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells."} -{"_id": 6986, "text": "A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes."} -{"_id": 6989, "text": "An American histoplasmosis that results_in inflammation located_in lung, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom mediastinal lymphadenopathy, has_symptom cough and has_symptom chest pain."} -{"_id": 6992, "text": "An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions."} -{"_id": 6995, "text": "A tuberculosis that involves infection of the mesenteric glands by tuberculosis causing mycobacteria. The symptoms include distended abdomen, persistent intestinal indigestion, diarrhea, flatulence, and abdominal pain."} -{"_id": 6998, "text": "An immune system disease that is related to the transplantation of cells, tissues and/or whole organs from one individual to another."} -{"_id": 7001, "text": "An ectothrix infectious disease that results_in non-inflammatory fungal infection located_in scalp and located_in skin, has_material_basis_in Microsporum audouinii."} -{"_id": 7004, "text": "A tracheal cancer that effects the airway that leads from the larynx to the bronchi."} -{"_id": 7007, "text": "A coagulation protein disease that is a hereditary abnormality which slows the blood clotting process. It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion."} -{"_id": 7010, "text": "An acquired immunodeficiency syndrome that results_in infection located_in brain, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom cognitive impairment, has_symptom motor dysfunction, and has_symptom behavioral change."} -{"_id": 7013, "text": "A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash."} -{"_id": 7016, "text": "A tuberculosis that is resistant to isoniazid and rifampicin, the two most powerful first-line anti-TB drugs."} -{"_id": 7019, "text": "A viral infectious disease that results_in infection in cattle, has_material_basis_in Bovine viral diarrhea virus 2, which is transmitted_by ingestion of infected food, or transmitted_by nasal secretions. The infection has_symptom low grade fever, has_symptom bloody diarrhea, and has_symptom bleeding in the eyes."} -{"_id": 7022, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection in dogs, cats and humans caused by cysticercoid larvae of Dipylidium caninum through ingestion of larvae contaminated flea, which results in diarrhea and restlessness."} -{"_id": 7025, "text": "An endothrix infectious disease that results_in anthropophilic fungal infection located_in skin, located_in nail and located_in scalp, has_material_basis_in Trichophyton tonsurans and results_in_formation_of scaling lesions."} -{"_id": 7028, "text": "A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction."} -{"_id": 7031, "text": "A genital herpes that results_in infection located_in skin of vulva, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2 and has_symptom lesions."} -{"_id": 7034, "text": "A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection."} -{"_id": 7037, "text": "An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness."} -{"_id": 7040, "text": "An impulse control disorder that involves the repeated impulse to steal for no great gain, when he or she has sufficient money to pay for the item and no need for what is stolen."} -{"_id": 7043, "text": "An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood."} -{"_id": 7046, "text": "A duodenal benign neoplasm that has_material_basis_in epithelial tissue with glandular origin."} -{"_id": 7049, "text": "An urticaria induced by external physical influences."} -{"_id": 7052, "text": "A Salmonella infectious disease that involves infection of the intestine caused by Salmonella enterica subsp arizonae, which is a gut inhabitant of reptiles. The symptoms include fever, headache, abdominal pain, vomiting, and diarrhea."} -{"_id": 7055, "text": "An endocrine system disease that is located_in the adrenal gland."} -{"_id": 7058, "text": "An amino acid metabolic disorder that involves defective proteins called carnitine transporters, which bring carnitine into cells and prevent its escape from the body preventing the body cannot utilize fats for energy."} -{"_id": 7061, "text": "A vascular disease that is characterized by compression at the superior thoracic outlet resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles."} -{"_id": 7064, "text": "A nasal cavity carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 7067, "text": "A type of ALS caused_by mutation located_in OPTN gene located_in chromosome 10."} -{"_id": 7070, "text": "A malaria caused by a parasite Plasmodium malariae, which is marked by recurrence of paroxysms at 72-hour intervals."} -{"_id": 7073, "text": "An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing."} -{"_id": 7076, "text": "A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis."} -{"_id": 7079, "text": "An alopecia areata that involves diffuse loss of hair over the whole scalp."} -{"_id": 7082, "text": "A syndrome that is characterized by the presence of at least three of the following: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities."} -{"_id": 7085, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness."} -{"_id": 7088, "text": "An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash."} -{"_id": 7091, "text": "A spinal chordoma that is located_in the sacrum."} -{"_id": 7094, "text": "An extrapulmonary tuberculosis that results in formation of tuberculomas located_in brain or located_in spinal cord."} -{"_id": 7097, "text": "A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas."} -{"_id": 7100, "text": "A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern."} -{"_id": 7103, "text": "A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload."} -{"_id": 7106, "text": "A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy."} -{"_id": 7109, "text": "A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis."} -{"_id": 7112, "text": "A synostosis characterized by the fusion of carpal and tarsal bones, which causes stiffness and immobility of the hands and the feet."} -{"_id": 7115, "text": "A Strongylida infectious disease that involves infection of the small intestine of mammals, cats and dogs by the parasitic nematodes of genus Ancylostoma, Necator and Uncinaria."} -{"_id": 7118, "text": "A liver cancer that has_material_basis_in epithelial cells."} -{"_id": 7121, "text": "A cutaneous mycosis that results_in fungal infection located_in skin, located_in hair, and located_in nail, has_material_basis_in Epidermophyton, has_material_basis_in Microsporum, or has_material_basis_in Trichophyton, which invade the dead keratin and has_symptom itchy patches, and has_symptom red rash on the skin."} -{"_id": 7124, "text": "A pollen allergy triggered by Phleum pratense pollen."} -{"_id": 7127, "text": "A rhabdomyosarcoma wherein the mesenchymally-derived malignant cells resemble the primitive developing skeletal muscle of the embryo; it occurs most often in the head and neck area or in the genital or urinary organs."} -{"_id": 7130, "text": "A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Myodes glareolus . The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure."} -{"_id": 7133, "text": "An adenoma that is composed_of cells with a clear cytoplasm located_in ovary."} -{"_id": 7136, "text": "A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs."} -{"_id": 7139, "text": "A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia."} -{"_id": 7142, "text": "A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood."} -{"_id": 7145, "text": "An autosomal dominant disease characterized by variable combinations of microcephaly, limb malformations, esophageal and duodenal atresias, and learning disability/mental retardation."} -{"_id": 7148, "text": "A lymphocytic choriomeningitis that results_in inflammation located_in meninges and located_in brain, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom headache, has_symptom stiff neck, has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis."} -{"_id": 7151, "text": "An adenosarcoma and malignant uterine body mixed neoplasm that derives_from the glands that line the uterus."} -{"_id": 7154, "text": "A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source."} -{"_id": 7157, "text": "A prostate cancer that is located_in the prostate."} -{"_id": 7160, "text": "A primary systemic mycosis that results_in fungal infection located_in human body, has_material_basis_in Ascomycota phylum members."} -{"_id": 7163, "text": "A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability."} -{"_id": 7166, "text": "A prostate sarcoma that is located_in the prostate."} -{"_id": 7169, "text": "An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone."} -{"_id": 7172, "text": "A carbohydrate metabolism disorder that is characterized by abnormal accumulation or depletion of liver glycogen."} -{"_id": 7175, "text": "A Parabasalia infectious disease that involves infection with anaerobic flagellate parasites belonging to the order Tritrichomonadida, which are characterized by a single mastigont with four flagella, and both a comb-like structure and an infrakinetosomal body."} -{"_id": 7178, "text": "A medical disorder that is an illness caused by abnormalities in genes or chromosomes."} -{"_id": 7181, "text": "An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes."} -{"_id": 7184, "text": "A small intestine cancer that develops from epithelial cells and is located_in the small intestine."} -{"_id": 7187, "text": "A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure."} -{"_id": 7190, "text": "A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis."} -{"_id": 7193, "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis."} -{"_id": 7196, "text": "An osteochondrodysplasia characterized by generalized platyspondyly without significant long bone abnormalities and short stature."} -{"_id": 7199, "text": "A tularemia that results in formation of ulcerative lesions located_in gastrointestinal tract. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom muscle aches, and has_symptom vomiting."} -{"_id": 7202, "text": "A parasitic helminthiasis infectious disease that involves intestinal infection by the parasite of the genus Heterophyes. The symptoms are diarrhea and colicky abdominal pain. Migration of the eggs to the heart, results in fatal myocardial and valvular damage. Brain can also be infected."} -{"_id": 7205, "text": "A female reproductive organ cancer that is located_in the uterus."} -{"_id": 7208, "text": "A malignant neoplasm that derives_from the retina."} -{"_id": 7211, "text": "An organ system cancer that is manifested in the reproductive organs."} -{"_id": 7214, "text": "A neurodegenerative disease that is characterized by onset between ages 2 and 6 months of truncal hypotonia, athetosis, seizures, and ophthalmologic abnormalities, particularly optic atrophy and retinal degeneration."} -{"_id": 7217, "text": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes."} -{"_id": 7220, "text": "A viral infectious disease that results_in inflammation located_in intestine of turkeys, has_material_basis_in Turkey coronavirus, which is transmitted_by ingestion of food contaminated with feces, or transmitted_by fomites contaminated with feces. The infection has_symptom diarrhea, has_symptom anorexia, has_symptom decreased weight, and has_symptom depression."} -{"_id": 7223, "text": "A blepharitis that is characterized as a cyst in the eyelid that is caused by inflammation of a blocked meibomian gland, usually on the upper eyelid."} -{"_id": 7226, "text": "A small intestine cancer that is located_in the ileum."} -{"_id": 7229, "text": "A venous insufficiency that is characterized by aching pain, heaviness, swelling, cramps, itching, or tingling in the affected limb and is a chronic complication of deep venous thrombosis."} -{"_id": 7232, "text": "A germ cell and embryonal cancer that derives_from trophoblastic tissue."} -{"_id": 7235, "text": "An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland."} -{"_id": 7238, "text": "A syndrome that is characterized by delayed psychomotor development and visual impairment, often accompanied by short stature and has_material_basis_in homozygous or compound heterozygous mutation in the TUBGCP6 gene."} -{"_id": 7241, "text": "A vitamin B12 deficiency that is characterized by a lack of vitamin B12 intestinal absorption resulting from a deficiency in the B12 transport protein TCII."} -{"_id": 7244, "text": "A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities."} -{"_id": 7247, "text": "A nervous system benign neoplasm that is characterized as a nerve tissue tumor."} -{"_id": 7250, "text": "A parasitic protozoa infectious disease that involves infection caused by the members of the class Heterolobosea, which move with eruptive bulges and show transformation to a temporary flagellate stage."} -{"_id": 7253, "text": "An adenoma that derives_from epithelial cells which have clear cytoplasm."} -{"_id": 7256, "text": "A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment."} -{"_id": 7259, "text": "A peripheral nervous system neoplasm that is located_in the autonomic nervous system."} -{"_id": 7262, "text": "An autonomic nervous system neoplasm that derives_from immature nerve cells."} -{"_id": 7265, "text": "A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra."} -{"_id": 7268, "text": "A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm."} -{"_id": 7271, "text": "An anxiety disorder that has_symptom flashbacks, has_symptom bad dreams, has_symptom frightening thoughts, has_symptom avoidance or has_symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD."} -{"_id": 7274, "text": "A large intestine cancer that is located_in the terminal part of the large intestine."} -{"_id": 7277, "text": "A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord."} -{"_id": 7280, "text": "A cardiovascular system disease that is located_in the fibrous sac surrounding the heart."} -{"_id": 7283, "text": "A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton concentricum, which is characterized by ring-like growth in overlapping circles that may have an autosomal dominant genetic predisposition."} -{"_id": 7286, "text": "A Measles virus infectious disease that results_in inflammation located_in middle ear, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom pain in the ear."} -{"_id": 7289, "text": "A fruit allergy triggered by Prunus persica plant fruit food product."} -{"_id": 7292, "text": "An endocrine gland cancer located_in the parathyroid glands located in the neck."} -{"_id": 7295, "text": "An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system."} -{"_id": 7298, "text": "A skin disease where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion."} -{"_id": 7301, "text": "A hypersensitivity vasculitis that results_in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin."} -{"_id": 7304, "text": "An ovarian carcinoma that has_material_basis_in cells with clear cytoplasm and glycogen secreting hob nail cells."} -{"_id": 7307, "text": "A nasal cavity cancer that_has_material_basis_in epithelial cells."} -{"_id": 7310, "text": "A substance abuse that involves the recurring use of cannabis despite negative consequences."} -{"_id": 7313, "text": "A bullous skin disease characterized by skin lesions and scaring and located_in mucous membranes and located_in skin."} -{"_id": 7316, "text": "An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint."} -{"_id": 7319, "text": "A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media."} -{"_id": 7322, "text": "An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle."} -{"_id": 7325, "text": "A Herpesviridae infectious disease that results_in infection, has_material_basis_in Human herpesvirus 8."} -{"_id": 7328, "text": "A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement."} -{"_id": 7331, "text": "A methylmalonic acidemia that has_material_basis_in deficiency in synthesis of both AdoCbl and MeCbl (cblC) and is characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl), which results in decreased activity of the respective enzymes methylmalonyl-CoA mutase."} -{"_id": 7334, "text": "A chordoma of skull base that is located in the clivus."} -{"_id": 7337, "text": "A skin carcinoma that has_material_basis_in squamous cells."} -{"_id": 7340, "text": "A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly."} -{"_id": 7343, "text": "A non-suppurative otitis media which is a collection of fluid that occurs in the middle ear space as a result of the negative pressure produced by altered Eustachian tube function. This can occur from viral upper respiratory infection or bacterial infection, or it can precede and/or follow acute bacterial otitis media."} -{"_id": 7346, "text": "A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face."} -{"_id": 7349, "text": "A toxoplasmosis that involves inflammation of the liver caused by the protozoan Toxoplasma gondii, which results in jaundice."} -{"_id": 7352, "text": "A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work."} -{"_id": 7355, "text": "A candidiasis that involves infection of the small intestine caused by Candida species, resulting in ulceration."} -{"_id": 7358, "text": "A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea."} -{"_id": 7361, "text": "A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system."} -{"_id": 7364, "text": "A gastrointestinal system disease that is located_in the gallbladder."} -{"_id": 7367, "text": "An iron metabolism disease that has_material_basis_in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload."} -{"_id": 7370, "text": "An anus carcinoma that derives_from epithelial cells of glandular origin located_in the anal gland."} -{"_id": 7373, "text": "A primary immunodeficiency disease that is the result in a mutation of a gene encoding one of the thirty complement system proteins, produced predominantly in liver, which function to defend against infection and produce inflammation."} -{"_id": 7376, "text": "A glioblastoma multiforme that is characterized by abnormally high levels of epidermal growth factor receptor and the absence of p53 mutations."} -{"_id": 7379, "text": "An agnosia that is a loss of the ability to recognize or identify objects by touch alone."} -{"_id": 7382, "text": "A coxsackie carditis that results_in inflammation located_in endocardium, has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions."} -{"_id": 7385, "text": "A viral infectious disease that results_in infection in primates and monkeys, has_material_basis_in Simian immunodeficiency virus, which is transmitted_by sexual contact, and transmitted_by ingestion of virus-infected milk. The infection The virus attacks the immune system leading to severe depletion of CD4+ T cells."} -{"_id": 7388, "text": "A brain disease that is characterized by brain damage resulting from the abnormal folding, clumping and accumulation of cellular proteins in the brain induced by prion proteins."} -{"_id": 7391, "text": "A male infertility disease characterized by the absence of any measurable level of sperm in semen."} -{"_id": 7394, "text": "A microcytic anemia characterized by paler than normal blood cells."} -{"_id": 7397, "text": "A Nematoda infectious disease that involves infection by parasitic worms of the class Enoplea, characterized by no body annules, no elaborate amphids, and five or more esophageal glands."} -{"_id": 7400, "text": "A Togaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Alphavirus, which is transmitted_by mosquito bite."} -{"_id": 7403, "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Rocio virus, which is transmitted_by Psorophora ferox and transmitted_by Aedes species of mosquitoes. The infection has_symptom abdominal distension, has_symptom confusion, has_symptom motor impairment, has_symptom difficulty in walking and maintaining balance, has_symptom meningeal irritation, and has_symptom cerebellar syndrome."} -{"_id": 7406, "text": "A viral infectious disease that results_in breakdown of red blood cells in horses, has_material_basis_in Equine infectious anemia virus, which is transmitted_by horse fly bite, transmitted_by deer fly bite, transmitted_by contact with saliva, milk, and body secretions, and transmitted_by contaminated needles and surgical equipment. The infection has_symptom anemia, has_symptom weakness, has_symptom swelling of the lower abdomen and legs, has_symptom weak pulse, and has_symptom irregular heartbeat."} -{"_id": 7409, "text": "A B cell deficiency that is an autosomal recessive disorder caused by mutation in the IgA (CD79 alpha) antigen receptor."} -{"_id": 7412, "text": "A respiratory allergy triggered by pollen."} -{"_id": 7415, "text": "A RNA virus infectious disease that results_in infection, has_material_basis_in ssRNA positive-strand viruses, no DNA stage, which possess positive-sense single-stranded RNA genomes."} -{"_id": 7418, "text": "A stomach carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 7421, "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia."} -{"_id": 7424, "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Human astrovirus, which is transmitted_by ingestion of contaminated food. The infection has_symptom watery diarrhea, has_symptom nausea, has_symptom abdominal pain, has_symptom vomiting, and has_symptom fever."} -{"_id": 7427, "text": "A neuromuscular junction disease that is characterized by weakness and easy fatiguability resulting from a genetic defect at the junction where the nerve stimulates muscle activity that result in muscle weakness and may affect nerve cells (presynaptic), muscle cells (postsynaptic) or the space between nerve and muscle cells (synaptic)."} -{"_id": 7430, "text": "An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs."} -{"_id": 7433, "text": "A small intestine cancer that has_material_basis_in cells of the neuroendocrine system."} -{"_id": 7436, "text": "A cecal benign neoplasm that has_material_basis_in epithelial tissue with glandular origin."} -{"_id": 7439, "text": "An adamantinoma that is located_in the long bones and results_in focal epithelial differentiation."} -{"_id": 7442, "text": "A viral infectious disease that results_in inflammation located_in lungs, has_material_basis_in Ovine progressive pneumonia virus, which is transmitted_by droplet spread of oronasal secretion, and transmitted_by ingestion of contaminated milk or colostrum. The infection has_symptom coughing, has_symptom bronchial exudate, has_symptom depression, and has_symptom fever."} -{"_id": 7445, "text": "A cell type benign neoplasm that has_physical_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood."} -{"_id": 7448, "text": "An autosomal dominant disease that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose."} -{"_id": 7451, "text": "A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton."} -{"_id": 7454, "text": "A fruit allergy triggered by Solanum lycopersicum plant fruit food product."} -{"_id": 7457, "text": "A Parkinson's disease caused by mutation in the FBXO7 gene located on chromosome 22q12.3."} -{"_id": 7460, "text": "Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure."} -{"_id": 7463, "text": "A gingival overgrowth characterized by benign, slowly progressive, nonhemorrhagic, fibrous enlargement of the oral masticatory mucosa."} -{"_id": 7466, "text": "An immune system disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the exocrine system."} -{"_id": 7469, "text": "A soft tissue infectious disease that involves accumulation of pus in the pleural cavity as a result of infection within the lung (pneumonia) or a lung abscess spreading into the space. The symptoms include cough, fever, chest pain, sweating and shortness of breath."} -{"_id": 7472, "text": "A trachea carcinoma that is characterized by the presence of squamous cells, mucus-secreting cells, and intermediate cells."} -{"_id": 7475, "text": "An intestinal cancer that is located_in the small intestine."} -{"_id": 7478, "text": "An AIDS-related Kaposi's sarcoma and gastric Kaposi's sarcoma that is located_in the stomach."} -{"_id": 7481, "text": "A bone cancer and jaw disease that is located_in the jaw and results_in a swollen jaw, results_in numbness or a tingling sensation in jaw, and results_in an abnormal growth of the jaw bone."} -{"_id": 7484, "text": "A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache."} -{"_id": 7487, "text": "A prostate rhabdomyosarcoma that is most common in children."} -{"_id": 7490, "text": "A type 2 diabetes that involves severe lipodystrophy in addition to the traditional signs of diabetes."} -{"_id": 7493, "text": "An American histoplasmosis that results_in inflammation located_in meninges, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and results_in_formation_of focal mass lesions, has_symptom headache, has_symptom confusion, has_symptom decreased level of consciousness, has_symptom cranial nerve deficits, and has_symptom seizures."} -{"_id": 7496, "text": "A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex."} -{"_id": 7499, "text": "A pulmonary tuberculosis involving inflammation that causes extensive thickening of the walls of the trachea with luminal narrowing."} -{"_id": 7502, "text": "A sarcoma of colon that is located_in the colon."} -{"_id": 7505, "text": "A bone cancer and neoplasm of chest wall and sternal disorder that is located_in the sternum."} -{"_id": 7508, "text": "An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional."} -{"_id": 7511, "text": "A Chromadorea infectious disease that involves infection by parasitic nematodes of the order Rhabditida, characterized by oral aperture with 2, 3 or 6 lips."} -{"_id": 7514, "text": "A lymphocytic choriomeningitis that results_in inflammation located_in meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom headache, and has_symptom stiff neck."} -{"_id": 7517, "text": "An inherited metabolic disorder resulting from a deficiency in vitamin or vitamin cofactor transport or metabolism."} -{"_id": 7520, "text": "An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system."} -{"_id": 7523, "text": "A male reproductive organ cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is_located_in the Cowper's gland."} -{"_id": 7526, "text": "Hydrops fetalis is a alpha thalassemia characterized by an abnormal accumulation of serous fluid in the fetal tissues, as in erythroblastosis fetalis."} -{"_id": 7529, "text": "An adult sarcoma of soft tissue and myxoid chondrosarcoma that is composed_of multiple lobules of chondroblast-like cells, arranged in cords and strands, embedded in a myxoid stroma, and separated by fibrous septa."} -{"_id": 7532, "text": "A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening."} -{"_id": 7535, "text": "An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness."} -{"_id": 7538, "text": "An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands."} -{"_id": 7541, "text": "A speech disorder that involves the automatic repetition of vocalizations made by another person."} -{"_id": 7544, "text": "A muscle tissue disease characterized by muscles unusually sensitive to movement or pressure; the proximal muscles are most affected, especially the thighs."} -{"_id": 7547, "text": "A subcutaneous mycosis that results_in fungal infection located_in skin and located_in subcutaneous tissue, has_material_basis_in Fungi incertae sedis taxon members."} -{"_id": 7550, "text": "A gastritis that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting."} -{"_id": 7553, "text": "A drug dependence that involves the continued use of cannabis despite problems related to use of the substance."} -{"_id": 7556, "text": "An ehrlichiosis that results_in infection located_in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted_by lone start tick (Amblyomma americanum ). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash."} -{"_id": 7559, "text": "A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells."} -{"_id": 7562, "text": "A gonadal dysgenesis that is characterized by the lack of functional ovaries to induce puberty in an otherwise 46,XX female."} -{"_id": 7565, "text": "A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs."} -{"_id": 7568, "text": "A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice."} -{"_id": 7571, "text": "A lipoma that is a deep-seated, firm, yellow tumors that characteristically occur on the legs of women."} -{"_id": 7574, "text": "A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue."} -{"_id": 7577, "text": "An Alveolata infectious disease that involves infection caused by the members of the phylum Ciliophora, which are characterized by the presence of hair-like organelles called cilia."} -{"_id": 7580, "text": "An opportunistic mycosis that results_in fungal infection located_in human body, has_material_basis_in Fungi incertae sedis taxon members."} -{"_id": 7583, "text": "An esophageal carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 7586, "text": "A cervix carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 7589, "text": "A lipoma that is characterized by floret giant cells with overlapping nuclei."} -{"_id": 7592, "text": "An amnestic disorder that involves the impaired or lost ability to memorize new things."} -{"_id": 7595, "text": "A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart."} -{"_id": 7598, "text": "A leukemia that arises from changes in the tissues forming white blood cells and characterized by a normal or decreased number of white blood cells in the circulating blood."} -{"_id": 7601, "text": "An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation."} -{"_id": 7604, "text": "A hereditary ataxia that has_material_basis_in autosomal recessive inheritance."} -{"_id": 7607, "text": "A non-syndromic intellectual disability characterized by an autosomal dominant inheritance pattern."} -{"_id": 7610, "text": "A non-suppurative otitis media that is characterized by effusion with very thick and glue-like middle ear fluid which may cause conductive hearing impairment."} -{"_id": 7613, "text": "A dsDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Herpesviridae viruses."} -{"_id": 7616, "text": "A multiple sclerosis that is characterised by a worsening of disability, rather than by relapses followed by recovery, which progressively worsens until a steady progression of disability replaces the cycles of attacks."} -{"_id": 7619, "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice."} -{"_id": 7622, "text": "An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth."} -{"_id": 7625, "text": "A Mumps virus infectious disease that results_in inflammation located_in liver, has_material_basis_in Mumps virus, which is transmitted_by contact with the oronasal secretions of an infected person. The infection causes swelling of parotid gland and has_symptom fever, has_symptom nausea, has_symptom anorexia, and has_symptom dark urine."} -{"_id": 7628, "text": "A cardiovascular cancer located_in the heart."} -{"_id": 7631, "text": "A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon."} -{"_id": 7634, "text": "A female reproductive system cancer that is located_in the vagina."} -{"_id": 7637, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death."} -{"_id": 7640, "text": "A tooth disease characterized by a localized collection of pus associated with a tooth."} -{"_id": 7643, "text": "A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress."} -{"_id": 7646, "text": "An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas."} -{"_id": 7649, "text": "An astrocytoma that is characterized by cells with regular, round to oval nuclei."} -{"_id": 7652, "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet."} -{"_id": 7655, "text": "A primary syphilis that is characterized by occurence of painless sores on the anus, which is caused by the spirochete Treponema pallidum."} -{"_id": 7658, "text": "A biliary tract neoplasm characterized by multiple papillary tumors in the intrahepatic and/or extrahepatic biliary tree."} -{"_id": 7661, "text": "A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss."} -{"_id": 7664, "text": "A herpes zoster that is complicated_by AIDS."} -{"_id": 7667, "text": "A kidney cancer that is located_in the kidney's connective tissue."} -{"_id": 7670, "text": "A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death."} -{"_id": 7673, "text": "An autosomal dominant cerebellar ataxia that has_material_basis_in expansion of CAG triplet repeats (glutamine) encoding a polyglutamine tract in the atrophin-1 protein."} -{"_id": 7676, "text": "A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy."} -{"_id": 7679, "text": "An amino acid metabolic disorder that involves failures of carboxylation enzymes."} -{"_id": 7682, "text": "A cerebrum cancer that is located_in the cerebral ventricles."} -{"_id": 7685, "text": "An ectothrix infectious disease that results_in geophilic fungal infection located_in glabrous skin, located_in scalp and located_in hair, has_material_basis_in Microsporum gypseum, which results_in_formation_of inflammatory lesions."} -{"_id": 7688, "text": "A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease."} -{"_id": 7691, "text": "A lymph node tuberculosis that is characterized by a peri-hilar or paratracheal lymph adenopathy after the primary infection. The diseased lymph nodes and associated inflammatory edema compress the airways resulting in partial or total airway obstruction. When a caseating lymph node erupts into an airway, aspiration of caseous material results in dense alveolar consolidation of the affected segment/lobe."} -{"_id": 7694, "text": "An auditory system cancer that is located_in the middle ear."} -{"_id": 7697, "text": "A mitochondrial metabolism disease characerized by a highly variable phenotype. Some patients have multisystem involvement of the brain, heart, muscle, liver, and kidneys resulting in death in infancy, whereas others have only isolated cardiac or muscle involvement with onset in adulthood and normal cognition. It s caused by homozygous or compound heterozygous mutation in the nuclear-encoded SDHA gene on chromosome 5p, the nuclear-encoded SDHAF1 gene on chromosome 19q, or the nuclear-encoded SDHD gene on chromosome 11q23."} -{"_id": 7700, "text": "An ovarian cancer that is derived_from ovarian surface epithelium."} -{"_id": 7703, "text": "An autosomal recessive disease that is characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form) resulting from dysfunction of ciliary proteins (ciliopathy)."} -{"_id": 7706, "text": "A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image)."} -{"_id": 7709, "text": "An eosinophilic pneumonia which slowly progresses over weeks to months. Life-threatening shortness of breath can develop if the condition is not treated. Individuals are often diagnosed with asthma before the advent of this disease."} -{"_id": 7712, "text": "A Pseudomonas infectious disease that involves infection of the intestine caused by the bacterial genus Pseudomonas, which can result in diarrhea, necrotizing enterocolitis, typhlitis and rectal abscess."} -{"_id": 7715, "text": "A colitis caused_by diversion of the fecal stream due to complication of ileostomy or colostomy."} -{"_id": 7718, "text": "A communication disorder that involves difficulty with the act of speech production."} -{"_id": 7721, "text": "An intestinal disease that involves intestinal infection caused by viruses, bacteria, fungi and parasites."} -{"_id": 7724, "text": "A pulmonary tuberculosis characterized by tubercles formation which coalesce into consolidated areas. Caseation and softening of these areas, with involvement of the interstitial tissue, lead to the formation of a cavity. The symptoms include fever, increased cough and sputum."} -{"_id": 7727, "text": "An African histoplasmosis that results_in inflammation located_in retina, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and results_in_formation_of lesions."} -{"_id": 7730, "text": "An osteomyelitis that has_material_basis_in infection located_in petrous part of temporal bone."} -{"_id": 7733, "text": "An eating disorder that is characterized by effortless regurgitation of most meals following consumption."} -{"_id": 7736, "text": "A spotted fever that has_material_basis_in Rickettsia sibirica, which is transmitted_by ticks (Dermacentor nuttalli, Dermacentor marginatus and Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash."} -{"_id": 7739, "text": "A colitis characterized by a distinctive thickening of the subepithelial collagen table."} -{"_id": 7742, "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma."} -{"_id": 7745, "text": "A jaw cancer and maxillary disease that effects the maxilla or upper jaw."} -{"_id": 7748, "text": "An autosomal recessive disease that is characterized by microcephaly, intellectual deficit and early onset symptoms of achalasia (abnormal enlargement of the esophagus, impaired peristalsis, cardiospasm, recurrent vomiting and respiratory infections)."} -{"_id": 7751, "text": "A phlebitis that results from a blood clot in the vessel."} -{"_id": 7754, "text": "A Human immunodeficiency virus infectious disease that results_in microvascular changes located_in retina, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom cotton-wool spots, has_symptom retinal hemorrhages, and has_symptom microaneurysms."} -{"_id": 7757, "text": "An autosomal dominant disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium."} -{"_id": 7760, "text": "A physical disorder that is the result of structural, biochemical or electrical abnormalities in the brain or spinal cord, or in the nerves leading to or from them, can result in symptoms such as paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain and altered levels of consciousness."} -{"_id": 7763, "text": "A pervasive developmental disorder that is a rare condition characterized by late onset (>3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress."} -{"_id": 7766, "text": "A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots."} -{"_id": 7769, "text": "An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins."} -{"_id": 7772, "text": "A refractory hematologic cancer that is a mature B cell cancer that does not yield readily to treatment."} -{"_id": 7775, "text": "A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep."} -{"_id": 7778, "text": "A severe acute respiratory syndrome that results_in infection located_in lungs, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom myalgia, has_symptom lethargy, has_symptom cough, has_symptom sore throat, has_symptom shortness of breath, and other breathing difficulties which may lead to death as a result of respiratory failure."} -{"_id": 7781, "text": "A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located_in neuromuscular junction, resulting in descending muscle paralysis, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F."} -{"_id": 7784, "text": "A female reproductive organ cancer that is located_in the cervix."} -{"_id": 7787, "text": "A otitis which involves inflammation of the middle ear."} -{"_id": 7790, "text": "An esophageal carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 7793, "text": "A genital herpes that results_in infection located_in skin of penis, has_material_basis_in Human herpesvirus 1 and Human herpesvirus 2 and has_symptom lesions, and has_symptom swollen glands in the groin area."} -{"_id": 7796, "text": "A Simplexvirus infectious disease that results_in inflammation located_in esophagus, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2. The infection has_symptom difficulty swallowing, has_symptom fever, has_symptom herpetic lesions and has_symptom painful swallowing."} -{"_id": 7799, "text": "A liver disease that is characterized by an accumulation of bile in the liver resulting from a reducted number of liver small bile ducts."} -{"_id": 7802, "text": "A carbohydrate metabolic disorder characterized by the buildup of lactic acid in the body and a variety of neurological problems and caused by a deficiency of one of the three enzymes in the pyruvate dehydrogenase complex."} -{"_id": 7805, "text": "A female reproductive organ cancer that is located_in the ovary."} -{"_id": 7808, "text": "A penis carcinoma that has_material_basis_in squamous cells."} -{"_id": 7811, "text": "An idiopathic interstitial pneumonia which is a distinctive type of chronic fibrosing interstitial pneumonia with thick scarring in the lung creating a honeycomb appearance. The main symptoms start insidiously as shortness of breath on exertion, cough, and diminished stamina. Other common complaints include weight loss and fatigue. The level of oxygen in the blood decreases, and the skin may take on a bluish tinge (called cyanosis) and the ends of the fingers may become thick or club-shape. In most people, symptoms worsen over a period ranging from about 6 months to several years."} -{"_id": 7814, "text": "A syndrome characterized by parkinsonism, hypoventilation, depression, and weight loss; caused by heterozygous mutation in the DCTN1 gene on chromosome 2p13.. The mean age at onset is 48 years; the mean disease duration is five years. Parkinsonism and psychiatric changes (depression, apathy, character changes, and withdrawal) tend to occur early; severe weight loss and hypoventilation manifest later."} -{"_id": 7817, "text": "A leukemia that develops slowly."} -{"_id": 7820, "text": "An autosomal recessive disease characterized by the accumulation of deposits of calcium and other minerals in elastic fibers, which are a component of connective tissue, this can result in changes in the skin, eyes, cardiovascular system and gastrointestinal system."} -{"_id": 7823, "text": "A thyroid carcinoma that has_material_basis_in compact bundles of long spindle epithelial cells that merge with tubulopapillary structures and/or mucinous glands."} -{"_id": 7826, "text": "A nephroblastoma that results_in either bilateral disease or a family history of Wilms' tumour."} -{"_id": 7829, "text": "A type of ALS caused_by mutation located_in ERBB4 gene located_in chromosome 2."} -{"_id": 7832, "text": "A syndrome that is characterized by four typical symptoms: polymorphous exanthemas, recurrent high fever, leucocytosis and arthralgia."} -{"_id": 7835, "text": "An endocrine gland cancer located_in the thryoid gland located in the neck below the thyroid cartilage."} -{"_id": 7838, "text": "A viral infectious disease that results_in infection in sheep and rarely humans, has_material_basis_in Louping ill virus, which is transmitted_by sheep tick, Ixodes ricinus. The infection has_symptom lethargy, has_symptom muscle pains, has_symptom fever, and has_symptom focal neurological signs."} -{"_id": 7841, "text": "An esophageal disease that is characterized by an inability of the esophagus to move food toward the stomach resulting from the lower esophogeal sphincter not fully relaxing during swallowing."} -{"_id": 7844, "text": "A syndrome that is characterized by intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, genital abnormalities and has_physical_basis_in heterozygous mutation in the CDKN1C gene."} -{"_id": 7847, "text": "A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis."} -{"_id": 7850, "text": "A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull."} -{"_id": 7853, "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine in goats, pigs and humans by the nematode Oesophagostomum bifurcum. The symptoms are a low-grade fever, tenderness in the lower-right quadrant and painless cutaneous masses in the lower abdominal region. Rarely, Oesophagostomum spp will perforate the bowel wall, causing purulent peritonitis or migrate to the skin, producing cutaneous nodules."} -{"_id": 7856, "text": "An anogenital venereal wart that results_in infection located_in skin of urethra, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct sexual contact with the skin of an infected partner. The infection has_symptom urethral warts."} -{"_id": 7859, "text": "A parasitic helminthiasis infectious disease that involves infection by parasitic worms known as flukes, which are carried to various organs through blood stream."} -{"_id": 7862, "text": "A myositis that results_in inflammation located_in muscle or located_in skin where a skin rash is often seen prior to the onset of muscle weakness. The disease may result from either a viral infection or an autoimmune reaction."} -{"_id": 7865, "text": "An atrial fibrillation that has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes."} -{"_id": 7868, "text": "A legionellosis that involves a milder respiratory illness without pneumonia. Symptoms include fever, headache and muscle aches which last for 2 to 5 days."} -{"_id": 7871, "text": "A focal dystonia that is characterized by a prolonged involuntary upward deviation of the eyes."} -{"_id": 7874, "text": "An eating disorder that is characterized by an appetite for non-nutritive substances or food ingredients."} -{"_id": 7877, "text": "A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp."} -{"_id": 7880, "text": "A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge."} -{"_id": 7883, "text": "A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred."} -{"_id": 7886, "text": "A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals."} -{"_id": 7889, "text": "A communication disorder that involves both the receptive and expressive areas of communication may be affected in any degree, from mild to severe."} -{"_id": 7892, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation."} -{"_id": 7895, "text": "A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. The legs cross at the knees, making it difficult to walk."} -{"_id": 7898, "text": "A synostosis that results_in craniosynostosis and syndactyly."} -{"_id": 7901, "text": "A Retroviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Lentivirus, which is transmitted_by sexual contact, transmitted_by breast feeding, and transmitted_by contact of infected blood with any open wound."} -{"_id": 7904, "text": "A gastrointestinal system cancer that is located_in the pharynx."} -{"_id": 7907, "text": "A mollusc allergy triggered by snails."} -{"_id": 7910, "text": "A rhabdomyosarcoma and sarcoma of the mediastinum that is located_in the mediastinum and affects children and adolescents."} -{"_id": 7913, "text": "A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head."} -{"_id": 7916, "text": "An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer."} -{"_id": 7919, "text": "A nipple carcinoma that is located_in the nipple duct."} -{"_id": 7922, "text": "A renal cell carcinoma that is characterized by the development of multiple, bilateral papillary renal tumors."} -{"_id": 7925, "text": "A hemangiopericytoma and sarcoma of the mediastinum that is located_in the mediastinum."} -{"_id": 7928, "text": "A leiomyosarcoma and sarcoma of lung that is located_in the lung."} -{"_id": 7931, "text": "A dermatophytosis that results_in fungal infection located_in skin, limited to the stratum corneum of the epidermis, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, and has_symptom red colored skin rash. The border of the rash lesions look scaly."} -{"_id": 7934, "text": "A Paramyxoviridae infectious disease that results_in infection in cattle and humans, has_material_basis_in Pneumovirus, which is transmitted_by contact with the respiratory secretions."} -{"_id": 7937, "text": "An aspergillosis that presents as a clump of tangled mass of Aspergillus fungus fibres, blood clots, and white blood cells, which exists in the cavities of the lungs that develop in an area of previous lung disease or lung scarring."} -{"_id": 7940, "text": "A penile cancer that is located_in the skin or tissues of the penis."} -{"_id": 7943, "text": "A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape."} -{"_id": 7946, "text": "A histiocytic and dendritic cell cancer that derives_from the lymph nodes, derives_from the skin, derives_from the liver, derives_from the spleen and derives_from bones."} -{"_id": 7949, "text": "A viral infectious disease that results_in infection in cats, located_in peritoneum, has_material_basis_in Feline infectious peritonitis virus, which is transmitted_by contact with the infected cat, and transmitted_by congenital method. The infection has_symptom sneezing, has_symptom watery eyes, has_symptom nasal discharge, and has_symptom accumulation of fluid in the abdomen."} -{"_id": 7952, "text": "A hereditary spastic paraplegia associated with dementia."} -{"_id": 7955, "text": "A specific phobia that involves an irrational fear of contracting a disease."} -{"_id": 7958, "text": "A substance abuse that involves the recurring use of barbiturate drugs despite negative consequences."} -{"_id": 7961, "text": "A maxillary sinusitis which lasts for less than 4 weeks."} -{"_id": 7964, "text": "A cryptococcosis that results_in inflammation located_in meninges, has_material_basis_in Cryptococcus neoformans and has_symptom headache, has_symptom nausea, has_symptom staggering gait, has_symptom dementia, has_symptom blurred vision and has_symptom confusion."} -{"_id": 7967, "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice."} -{"_id": 7970, "text": "A type of ALS with loci associated with the disease located_in chromosome 18."} -{"_id": 7973, "text": "A demyelinating disease characterized by the fact that the demyelinated tissues form concentric layers."} -{"_id": 7976, "text": "A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer."} -{"_id": 7979, "text": "An acrocephalosyndactylia that has_material_basis_in mutation in the GLI3 gene which results_in abnormal development located_in limb, located_in head, located_in face."} -{"_id": 7982, "text": "A male reproductive system cancer that is located_in the testicles."} -{"_id": 7985, "text": "A skin hemangioma characterized by the presence of small red dots that cluster together to form a linear or snake-like array or ring-shaped pattern located_in the blood vessels of the skin."} -{"_id": 7988, "text": "A cholesteatoma located_in paranasal sinus."} -{"_id": 7991, "text": "A pharynx cancer that is located_in the oropharynx."} -{"_id": 7994, "text": "A large intestine cancer that is located_in the anus."} -{"_id": 7997, "text": "An agnosia that is a loss of motion perception."} -{"_id": 8000, "text": "A neurodegenerative disease that is characterized by an abnormal accumulation of iron in the brain and progressive degeneration of the nervous system."} -{"_id": 8003, "text": "An immune system cancer located_in the thymus."} -{"_id": 8006, "text": "An autosomal recessive disease characterized_by is a rare autosomal recessive disease, characterized by microcephaly with brain anomalies including CA in some cases, intellectual disability, and early-infantile-onset nephrotic syndrome."} -{"_id": 8009, "text": "A congenital heart septal defect characterized by an abnormal or inadequate fusion of the superior and inferior endocardial cushions with the mid portion of the atrial septum and the muscular portion of the ventricular septum, thus allowing extra blood to circulate the lungs."} -{"_id": 8012, "text": "An extrapulmonary tuberculosis that results in formation of tiny lesions in all the organs."} -{"_id": 8015, "text": "A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Piedraia hortae, an ascomycetous fungus forming hard black nodules on the shafts of the scalp, beard, moustache and pubic hair."} -{"_id": 8018, "text": "A focal dystonia that involves the muscles that control the vocal cords, resulting in strained or breathy speech."} -{"_id": 8021, "text": "A rickets characterized by low levels of serum phosphate and elevated levels of ALP and phosphaturia and that has_material_basis_in autosomal dominant inheritance."} -{"_id": 8024, "text": "A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs."} -{"_id": 8027, "text": "A thymus cancer that derives_from epithelial cells. The tumor cells in a thymic carcinoma look very different from the normal cells of the thymus, grow more quickly, and have usually spread to other parts of the body when the cancer is found."} -{"_id": 8030, "text": "A (-)ssRNA virus infectious disease that results_in infection in rodents and humans, has_material_basis_in Bunyaviridae viruses, which are transmitted_by arthropod vectors."} -{"_id": 8033, "text": "A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus."} -{"_id": 8036, "text": "A syndrome that is characterized by developmental delay, intellectual disability, muscle weakness (hypotonia), epilepsy, distinctive facial features and congenital malformations of the heart, urogenital tract and the central nervous system, and has_physical_basis_in either a chromosome 17 (17q21.31) microdeletion or a mutation in the KANSL1-gene."} -{"_id": 8039, "text": "A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain."} -{"_id": 8042, "text": "A tick infestation that is characterized by an acute, ascending, flaccid motor paralysis, which is caused by the introduction of a neurotoxin into humans during attachment and feeding by the females of several tick species such as Dermacentor andersoni, Dermacentor variabilis, Amblyomma americanum, Amblyomma maculatum, Ixodes scapularis, Ixodes pacificus, Ixodes holocyclus, Rhipicephalus sanguineus and Otobius megnini. The symptoms include local inflammation, edema and hemorrhage."} -{"_id": 8045, "text": "A myiasis that involves parasitic infestation of warble flies of the genus Hypoderma, on cattle and deer and Dermatobia hominis on humans. The larvae of human botfly, Dermatobia hominis, feed in a subdermal cavity causing cutaneous swellings on the body or scalp that may produce discharges and be painful."} -{"_id": 8048, "text": "A intestinal cancer that is located_in the appendix."} -{"_id": 8051, "text": "A primary bacterial infectious disease that refers to a group of diseases, located_in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted_by lice, transmitted_by fleas, and transmitted_by mites."} -{"_id": 8054, "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Trivittatus virus, which is transmitted_by Ochlerotatus trivittatus mosquito. The infection has_symptom headache, has_symptom fever, has_symptom disorientation, has_symptom tremors, has_symptom convulsions, has_symptom paralysis, and has_symptom coma."} -{"_id": 8057, "text": "A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes."} -{"_id": 8060, "text": "A severe combined immunodeficiency that is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines. Lack of ADA causes accumulation of dATP."} -{"_id": 8063, "text": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis."} -{"_id": 8066, "text": "A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene."} -{"_id": 8069, "text": "A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts."} -{"_id": 8072, "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center."} -{"_id": 8075, "text": "An intestinal infectious disease and is_a Cytomegalovirus infectious disease that is complicated_by acquired immunodeficiency syndrome which results_in inflammation located_in colon and located_in small intestine, has_material_basis_in Cytomegalovirus in AIDS patients."} -{"_id": 8078, "text": "A syphilis that is characterized as having serologic proof of infection without signs or symptoms of disease."} -{"_id": 8081, "text": "A syndrome characterized by the combination of lower lip pits, cleft lip with or without cleft palate and cleft palate alone."} -{"_id": 8084, "text": "A nervous system disease that affects the peripheral nervous system."} -{"_id": 8087, "text": "A retinal disease that is characterized by nystagmus, sluggish or no pupillary responses, and severe vision loss or blindness."} -{"_id": 8090, "text": "A severe combined immunodeficiency that is caused when the DCLREI1, DNA cross-link repair 1C gene contains mutations resulting in the inability to repair DNA."} -{"_id": 8093, "text": "A spotted fever that has_material_basis_in Rickettsia conorii subsp israelensis, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities."} -{"_id": 8096, "text": "A Nematoda infectious disease that involves infection by parasitic worms of the class Chromadorea, characterized by body annules, elaborated and spiral amphids, and three esophageal glands."} -{"_id": 8099, "text": "An adrenal medulla cancer that is characterized by overproduction of adrenaline."} -{"_id": 8102, "text": "A syndrome that is characterized by hypotonia, congenital fiber type disproportion and dysharmonic skeletal maturation."} -{"_id": 8105, "text": "A keratosis of the hands and feet characterized by persistent, asymptomatic, yellowish to white papules and plaques associated with fine-textured scalp hair and an atopic diathesis."} -{"_id": 8108, "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma."} -{"_id": 8111, "text": "A kidney cancer that affects the kidneys and typically located_in children."} -{"_id": 8114, "text": "A disease comprised of a group of signs and symptoms that occur together and characterize a particular abnormality."} -{"_id": 8117, "text": "A bone cancer that is located_in the femur."} -{"_id": 8120, "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Jamestown Canyon virus, which is transmitted_by Culiseta, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom headache, has_symptom fever, has_symptom neck stiffness, has_symptom photophobia, has_symptom nausea, has_symptom vomiting, and has_symptom seizures."} -{"_id": 8123, "text": "An opportunistic mycosis that results_in fungal infection located_in nose, located_in sinuses, located_in eyes, and located_in brain of immunocompromised individuals and has_symptom orbital cellulitis, has_symptom proptosis, has_symptom pus discharge from the nose, and has_symptom seizures."} -{"_id": 8126, "text": "A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood."} -{"_id": 8129, "text": "A bone benign neoplasm that has_material_basis_in odontogenic epithelium and is located_in bone."} -{"_id": 8132, "text": "A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia."} -{"_id": 8135, "text": "A syndrome that is haracterized by the development of a one or more tumors (gastrinoma) in the pancreas, duodenum, or both that secrete excessive levels of gastrin, a hormone that stimulates production of acid by the stomach."} -{"_id": 8138, "text": "A severe combined immunodeficiency that is characterized by the absence of T cells but normal numbers of B cells. CD3D is essential for T cell development."} -{"_id": 8141, "text": "A male reproductive organ cancer that is located_in the prostate."} -{"_id": 8144, "text": "An 2-hydroxyglutaric aciduria that involves damage to cerebellum affecting movement coordination resulting in problems with balance and muscle coordination (ataxia)."} -{"_id": 8147, "text": "A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction."} -{"_id": 8150, "text": "A focal dystonia that is characterized by distortions of the mouth and tongue."} -{"_id": 8153, "text": "A fruit allergy triggered by Prunus domestica plant fruit food product."} -{"_id": 8156, "text": "An Enterovirus infectious disease that involves inflammation located_in brain, has_material_basis_in group A coxsackievirus or has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom reduced level of consciousness, has_symptom confusion, has_symptom irritability, has_symptom seizures, and has_symptom coma."} -{"_id": 8159, "text": "A Mononegavirales infectious disease that results_in infection in animals and humans, has_material_basis_in Bornaviridae viruses."} -{"_id": 8162, "text": "An adult sarcoma of soft tissue and extraosseous osteosarcoma that is located in the soft tissues without direct attachment to the skeletal system and results in the production of osteoid, bone, or chondroid material."} -{"_id": 8165, "text": "An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall."} -{"_id": 8168, "text": "An achondrogenesis that results_in abnormal ossification of the located_in vertebral column or located_in spine."} -{"_id": 8171, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection by the nematode Dioctophyme renale in humans after eating undercooked food. The larvae are found in the subcutaneous nodules and kidneys."} -{"_id": 8174, "text": "A leiomyosarcoma and sarcoma of colon that is located_in the colon."} -{"_id": 8177, "text": "A hyperostosis of endosteal bone."} -{"_id": 8180, "text": "A commensal Helicobacter infectious disease that involves inflammation of the stomach lining caused by Helicobacter pylori, which contributes to ulcer formation by increasing acid production, interfering with the normal defenses against stomach acid, and producing toxins. The symptoms include indigestion and pain or discomfort in the upper abdomen."} -{"_id": 8183, "text": "A pneumoconiosis that results_in humans that also have rheumatoid arthritis."} -{"_id": 8186, "text": "A lymphocytic choriomeningitis that results_in inflammation located_in brain, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis."} -{"_id": 8189, "text": "An autosomal dominant disease that is characterized by fusion of the carpals, tarsals, and phalanges, short first metacarpals causing brachydactyly; and humeroradial fusion."} -{"_id": 8192, "text": "A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling."} -{"_id": 8195, "text": "A larynx cancer that has_material_basis_in epithelial cells."} -{"_id": 8198, "text": "A brain stem cancer that begins in the lower part of the brain on the floor of the skull."} -{"_id": 8201, "text": "A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies."} -{"_id": 8204, "text": "A vascular disease that is characterized by severe supine hypotension in late pregnancy, whose clinical presentation ranges from minimal cardiovascular alterations to severe shock, resulting from inferior vena cava compression by gravid uterus."} -{"_id": 8207, "text": "A primary bacterial infectious disease that results_in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash."} -{"_id": 8210, "text": "A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated."} -{"_id": 8213, "text": "A syndrome that occurs in human immunodeficiency virus (HIV) positive patients, which is accompanied by decreased kidney function. The spectrum of kidney involvement includes acute or chronic kidney disease, primarily tubular proteinuria and dense lymphocytic tubulointerstitial infiltrates predominantly composed of CD8 T cells."} -{"_id": 8216, "text": "An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues."} -{"_id": 8219, "text": "A tinea favosa that results_in anthropophilic fungal infection located_in scalp, has_material_basis_in Trichophyton schoenleinii. It is a chronic, scarring form of tinea capitis, which results_in_formation_of scutula and has_symptom permanent hair loss."} -{"_id": 8222, "text": "A disease of mental health in which the normally well-integrated functions of memory, identity, perception, or consciousness are separated (dissociated)."} -{"_id": 8225, "text": "A colitis caused_by introduction of various chemicals."} -{"_id": 8228, "text": "An achondrogenesis that has_material_basis_in mutation in the SLC26A2 gene which results_in umbilical or inguinal hernia and a prominent rounded abdomen."} -{"_id": 8231, "text": "An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands."} -{"_id": 8234, "text": "A bacterial pneumonia caused due to the infection by Gram-positive bacteria of genus Streptococcus which are the most common cause of community-acquired pneumonias."} -{"_id": 8237, "text": "An adrenal cortex disease characterized by small to normal sized adrenal glands containing multiple small cortical pigmented nodules."} -{"_id": 8240, "text": "An ethmoid sinus cancer that derives_from epithelial cells of glandular origin."} -{"_id": 8243, "text": "A lipid metabolism disorder characterized by an enzymatic defect that prevents long-chain fatty acids from being transported into the mitochondria."} -{"_id": 8246, "text": "A commensal bacterial infectious disease that involves infection of the intestine by the bacterium Clostridium difficile, which causes diarrhea, pseudomembranous colitis, toxic megacolon, intestinal perforation and sepsis. The symptoms include fever, loss of appetite, nausea and abdominal pain."} -{"_id": 8249, "text": "A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis."} -{"_id": 8252, "text": "An autosomal recessive disease that results from mutations in multiple BBS genes affecting cellular cilia structure or function (ciliopathy) resulting in variable presentation and characterized principally by obesity, retinitis pigmentosa,vision loss, polydactyly, mental retardation, hypogonadism, and renal failure in some cases."} -{"_id": 8255, "text": "An actinomycosis that involves invasion and infiltration located_in head and located_in neck, has_material_basis_in Actinomyces israelii. The infection results_in_formation_of abscesses following oral surgery or in patients with poor dental hygiene."} -{"_id": 8258, "text": "A syndrome characterized by a combination of hearing loss and visual impairment."} -{"_id": 8261, "text": "An astrocytoma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain."} -{"_id": 8264, "text": "A fallopian tube carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 8267, "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation."} -{"_id": 8270, "text": "An ovarian carcinoma that has_material_basis_in the lining of the ovary and produces a serum-like fluid."} -{"_id": 8273, "text": "A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance."} -{"_id": 8276, "text": "A middle ear disease characterized by an inflammation of the mucosal lining of the mastoid antrum and the mastoid air cell system inside the mastoid process."} -{"_id": 8279, "text": "A pulmonary tuberculosis involving inflammation of trachea and bronchi. The symptoms include dry cough followed by dyspnea, localized wheezing, hemoptysis, hoarseness, anorexia, weight loss, chest pain and fever."} -{"_id": 8282, "text": "A bile duct disease that is characterized by abnormal dilatation of the intrahepatic bile ducts."} -{"_id": 8285, "text": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain."} -{"_id": 8288, "text": "A gastrointestinal system cancer that is located_in the liver."} -{"_id": 8291, "text": "An inherited metabolic disorder characterized_by wide range of phenotypic variability; patients can have severe metabolic and CNS abnormalities, while others possess hyperglycerolemia and glyceroluria with no other apparent phenotype. It is caused by mutation in the GK gene on chromosome Xp21."} -{"_id": 8294, "text": "An electroclinical syndrome with onset in childhood between one and 12 years of age."} -{"_id": 8297, "text": "A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness."} -{"_id": 8300, "text": "An Epstein-Barr virus infectious disease and is_a lymphoma that derives_from lymphocytes, has_material_basis_in Human herpesvirus 4, which causes a growth activation of the lymphocytes that it infects."} -{"_id": 8303, "text": "A spinal muscular atrophy that is associated with the survival of motor neuron protein."} -{"_id": 8306, "text": "A synostosis characterized by coronal craniosynostosis, short stature, and aplasia or hypoplasia of the radial bone."} -{"_id": 8309, "text": "An urea cycle disorder that involves the accumulation of ammonia in the blood."} -{"_id": 8312, "text": "An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot."} -{"_id": 8315, "text": "A cholera that involves infection of the intestine caused by Vibrio cholerae O139 strain."} -{"_id": 8318, "text": "An eye and adnexa disease that is located_in the eye."} -{"_id": 8321, "text": "A tertiary neurosyphilis that is caused due to syphilis, which occurs suddenly and produces tinnitus and deafness when the cochlear branch is affected whereas vertigo, disturbances of equilibrium, spontaneous nystagmus and vomiting when the vestibular branch suffers. A combination of these symptoms are seen when both the branches are involved."} -{"_id": 8324, "text": "A type of ALS with juvenile onset caused_by mutation located_in SIGMAR1 gene (SETX) located_in chromosome 9."} -{"_id": 8327, "text": "A substance abuse that involves the recurring use of cocaine despite negative consequences."} -{"_id": 8330, "text": "A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding."} -{"_id": 8333, "text": "A phagocyte bactericidal dysfunction characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones may occur along with swollen areas of inflamed tissues known as granulomas that can be widely distributed."} -{"_id": 8336, "text": "An autosomal genetic disease that is characterized by microphthalmia or anophthalmia, pulmonary agenesis, and diaphragmatic defect."} -{"_id": 8339, "text": "An anxiety disorder that involves discress but neither delusions nor hallucinations."} -{"_id": 8342, "text": "A human papilloma virus related cervical squamous cell carcinoma that results_in infection located_in cervix, has_material_basis_in human papillomavirus (types 16 or 18), which cause papillary tumors with a transitional differentiation."} -{"_id": 8345, "text": "A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces."} -{"_id": 8348, "text": "A urinary system cancer that is located_in the kidney."} -{"_id": 8351, "text": "A lung disease that is a mycosis caused by fungal growth in the lungs."} -{"_id": 8354, "text": "A spotted fever that has_material_basis_in Rickettsia parkeri, which is transmitted_by Gulf Coast tick (Amblyomma maculatum). The infection has_symptom fever, has_symptom headache, has_symptom eschar, and has_symptom rash."} -{"_id": 8357, "text": "The most common type of familial ALS caused_by mutation located_in SOD1 gene located in chromosome 21."} -{"_id": 8360, "text": "A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty speaking, has_symptom difficulty swallowing, and has_symptom difficulty chewing."} -{"_id": 8363, "text": "A Mononegavirales infectious disease that results_in infection in animals and humans, has_material_basis_in Filoviridae viruses."} -{"_id": 8366, "text": "An oligohydramnios desribing the typical physical appearances of a fetus or neonate due to oligohydramnios experienced in the womb where there is a decrease in amniotic fluid volume sufficient to cause disruptions in morphogenesis of the fetus."} -{"_id": 8369, "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Togaviridae viruses."} -{"_id": 8372, "text": "A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine."} -{"_id": 8375, "text": "An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years."} -{"_id": 8378, "text": "A dysentery that involves protozoan infection."} -{"_id": 8381, "text": "A myocarditis characterized by dilated cardiomyopathy and a variety of types of dysrhythmia and conduction disturbances. It is caused by Corynebacterium diphtheriae."} -{"_id": 8384, "text": "A testis sarcoma that arises from mesenchymal cells and is located_in the testis."} -{"_id": 8387, "text": "A purulent acute otitis media with no perforation of the tympanic membrane."} -{"_id": 8390, "text": "A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness."} -{"_id": 8393, "text": "An osteoporosis caused by chronic glucocorticoid use. Glucocorticoids impair the replication, differentiation and function of osteoblasts and induce the apoptosis of mature osteoblasts and osteocytes; the also favor osteoclastogenesis leading to an increase in bone resorption."} -{"_id": 8396, "text": "A viral infectious disease that results_in infection located_in pharynx or located_in conjunctiva, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7, which are transmitted_by droplet spread of respiratory secretions or transmitted_by fomites. The infection has_symptom fever, has_symptom lymphadenopathy of the neck, and has_symptom headache."} -{"_id": 8399, "text": "A genetic disease that is characterized by slow growth before and after birth, intellectual disability that is usually severe to profound, skeletal abnormalities involving the arms and hands, and distinctive facial features."} -{"_id": 8402, "text": "An intestinal benign neoplasm that is located_in the colon."} -{"_id": 8405, "text": "An anthrax disease that results_in infection located_in mucosa of gastrointestinal tract, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite."} -{"_id": 8408, "text": "A syndrome that occurs in humans with psoriasis who also experience symptoms similar to arthritis."} -{"_id": 8411, "text": "A viral infectious disease that results_in inflammation located_in lung, has_material_basis_in Human parainfluenza virus 3, which is transmitted_by contact with the respiratory secretions of an infected person. The infection leads to the formation of multinucleated giant cells derived from the respiratory epithelium. The infection has_symptom shortness of breath, has_symptom cough, and has_symptom fever."} -{"_id": 8414, "text": "A notochordal cancer that derives_from cellular remnants of the notochord."} -{"_id": 8417, "text": "An epilepsy syndrome that is a group of clinical entities showing a cluster of electro-clinical characteristics, classified according to age at onset, cognitive and developmental antecedents and consequences, motor and sensory examinations, EEG features, provoking or triggering factors, and patterns of seizure occurrence with respect to sleep."} -{"_id": 8420, "text": "An arthritis that has_material_basis_in worn out cartilage located_in joint."} -{"_id": 8423, "text": "A carcinoma that derives_from myoepithelial cells."} -{"_id": 8426, "text": "A rickets that has_material_basis_in autosomal recessive inheritance mutation in the DMP1 gene and is haracterized by hypophosphatemia, rickets and/or osteomalacia and slow growth."} -{"_id": 8429, "text": "An adenoma that is composed_of adipose tissue."} -{"_id": 8432, "text": "A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium."} -{"_id": 8435, "text": "A breast carcinoma that derives_from the lining of milk ducts."} -{"_id": 8438, "text": "A carcinoma that derives_from squamous epithelial cells."} -{"_id": 8441, "text": "A cancer by anatomical entitiy that affects the organs in the abdominal cavity."} -{"_id": 8444, "text": "A multiple carboxylase deficiency that involves a deficiency in holocarboxylase synthetase."} -{"_id": 8447, "text": "A diverticulits characterized by the inflammation of a congenital diverticulum, which is a slight bulge of the small intestine present at birth."} -{"_id": 8450, "text": "A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain."} -{"_id": 8453, "text": "A myopathy is characterized by progressive skeletal muscle weakness degeneration."} -{"_id": 8456, "text": "A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve)."} -{"_id": 8459, "text": "A monogenic disease affects a person's height, muscles, skeleton, genitals, and appearance of the face."} -{"_id": 8462, "text": "A trypanosomiasis that involves infection of cattle caused by Trypanosoma vivax, which is transmitted by tsetse flies. The symptoms include fever, anemia, abortion, loss of appetite, lethargy, and progressive weight loss."} -{"_id": 8465, "text": "A type of ALS with juvenile onset caused_by mutation located_in alsin gene located_in chromosome 2."} -{"_id": 8468, "text": "An organ system cancer that located_in the heart and blood vessels."} -{"_id": 8471, "text": "A sinusitis which involves infection of ethmoid sinuses that causes pain or pressure behind and between the eyes, tearing, and headache over the forehead."} -{"_id": 8474, "text": "A dissociative disorder that involves the simultaneous display of multiple distinct identities or personalities."} -{"_id": 8477, "text": "A lymphatic system cancer that has_material_basis_in endothelial cells located_in lymphatic vessels."} -{"_id": 8480, "text": "A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition."} -{"_id": 8483, "text": "A nervous system cancer that is located_in the sensory system."} -{"_id": 8486, "text": "An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles)."} -{"_id": 8489, "text": "A sarcoma and malignant neoplasm of testis that is located_in the testis."} -{"_id": 8492, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Whitewater Arroyo virus, which is transmitted_by white-throated woodrats (Neotoma albigula). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, and has_symptom hemorrhagic manifestations."} -{"_id": 8495, "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Astroviridae viruses."} -{"_id": 8498, "text": "An ovarian embryonal carcinoma that occurs in childhood."} -{"_id": 8501, "text": "An ovary adenocarcinoma that derives_from the lining of a cavity that produces a serum-like fluid (a serous cavity)."} -{"_id": 8504, "text": "An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss."} -{"_id": 8507, "text": "A lymphatic system disease characterized by he presence of intestinal lymphangiectasia, mental retardation, and characteristic facial anomalies. It in inherited in an autosomal recessive pattern. Most individuals with Hennekam syndrome have characteristic facial abnormalities, such as a flat face with accompanying puffy eyelids and hypertelorism; the nasal bridge is typically flat and the ears are typically small. Congenital extremity and genital lymphedema is present in most patients."} -{"_id": 8510, "text": "A chordoma that derives_from the spine."} -{"_id": 8513, "text": "A myiasis that involves parasitic infestation of Cochliomyia hominivorax or Chrysomya bezziana larvae, which feed on the living tissues of warm-blooded animals. In Cochliomyia infestation, larvae migrate from the subdermis to other tissues in the body, causing extreme damage in the process. Chrysomya bezziana larvae feed and can cause permanent tissue damage."} -{"_id": 8516, "text": "A food allergy triggered by fish."} -{"_id": 8519, "text": "An amebiasis that involves infection of the intestine with Entamoeba histolytica trophozoites, which adhere to and kill colonic epithelial cells causing diarrhea with blood and mucus. The symptoms inlcude abdominal pain and fever."} -{"_id": 8522, "text": "An adnexa disease that is located_in the eyelid."} -{"_id": 8525, "text": "A congenital structural myopathy characterized by generally non-progressive muscle weakness of varying severity; certain muscle fibers show the presence of rod-like structures called nemaline bodies."} -{"_id": 8528, "text": "An opportunistic mycosis that involves infection of the body by fungi belonging to the phylum Ascomycota."} -{"_id": 8531, "text": "A thyroid carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer."} -{"_id": 8534, "text": "A chromosomal disease that has_material_basis_in deletion polymorphisms at chromosome location 22q11 and is characterized by variable developmental problems and schizoid features."} -{"_id": 8537, "text": "An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss."} -{"_id": 8540, "text": "A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries."} -{"_id": 8543, "text": "A combined T cell and B cell immunodeficiency that is caused by a defect in several genes encoding for B and T lymphocytes resulting in individuals with non-functional immune systems."} -{"_id": 8546, "text": "A retroperitoneal cancer that has_material_basis_in immature nerve cells."} -{"_id": 8549, "text": "An agnosia that is a loss of the ability to distinguishing environmental and non-verbal auditory cues including difficulty distinguishing speech from non-speech sounds even though hearing is usually normal."} -{"_id": 8552, "text": "A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances."} -{"_id": 8555, "text": "A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs."} -{"_id": 8558, "text": "An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress."} -{"_id": 8561, "text": "A fish allergy triggered by Oncorhynchus mykiss."} -{"_id": 8564, "text": "A Parabasalia infectious disease that involves infection with anaerobic flagellate parasites belonging to the order Trichomonadida. They typically have four to six flagella at the cell's apical pole."} -{"_id": 8567, "text": "A female reproductive organ cancer that is located_in fallopian tube."} -{"_id": 8570, "text": "A sarcoma and malignant tumor of nasal sinuses that is located_in the paranasal sinus."} -{"_id": 8573, "text": "A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain."} -{"_id": 8576, "text": "A refractive error characterized by the inability to see farther objects clearly."} -{"_id": 8579, "text": "A onchocerciasis that involves parasitic infection of the eye by the larvae of Onchocerca volvulus. The microfilariae migrate to the surface of the cornea. Punctate keratitis occurs in the infected area. In severe infection, sclerosing keratitis occurs, making the affected area become opaque leading to blindness."} -{"_id": 8582, "text": "A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin."} -{"_id": 8585, "text": "A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas."} -{"_id": 8588, "text": "A heart disease that is caused by high blood pressure."} -{"_id": 8591, "text": "A vulva carcinoma and has_material_basis_in squamous cells and is located_in the epidermis of the vulvar tissue."} -{"_id": 8594, "text": "A skin cancer that is located_in tissues of the skin and develops from epithelial cells."} -{"_id": 8597, "text": "An autosomal recessive disesase that is characterized by sensorineural hearing loss and ovarian failure."} -{"_id": 8600, "text": "A thoracic disease that is located_in the breast."} -{"_id": 8603, "text": "A congenital hypoplastic anemia that is characterized by anemia (low red blood cell counts) with decreased erythroid progenitors in the bone marrow and has_material_basis insufficient levels of red blood cells due to bone marrow dysfunction."} -{"_id": 8606, "text": "An interstitial lung disease that is caused by the inhalation of dust."} -{"_id": 8609, "text": "A pericarditis characterized by inflammation, occurring after injury, located_in pericardium."} -{"_id": 8612, "text": "A hematoloic cancer that is located_in the blood or bone marrow that has come back in a patient."} -{"_id": 8615, "text": "An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain."} -{"_id": 8618, "text": "A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis."} -{"_id": 8621, "text": "An autosomal recessive disease that is characterized by mental retardation, cataracts, coloboma, kyphosis, and coarse facial features and has_material_basis_in mutation in the SRD5A3 gene."} -{"_id": 8624, "text": "An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods."} -{"_id": 8627, "text": "An agnosia that is a loss of the ability to recognize a color, while being able to perceive or distinguish it."} -{"_id": 8630, "text": "A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue."} -{"_id": 8633, "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice."} -{"_id": 8636, "text": "An autosomal recessive disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1)."} -{"_id": 8639, "text": "A mixed neoplasm that is seen mostly in early infancy and that consists of classic and cellular (atypical) variants."} -{"_id": 8642, "text": "A secretory diarrhea caused_by mutation in the SLC26A3 gene."} -{"_id": 8645, "text": "A type of ALS caused_by mutation located_in ANG gene located_in chromosome 14."} -{"_id": 8648, "text": "A Cytomegalovirus infectious disease that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 5, has_symptom nausea, has_symptom vomiting, has_symptom headache, has_symptom abdominal pain, has_symptom dark urine, and has_symptom jaundice. Clinical feature includes atypical lymphocytes in the blood."} -{"_id": 8651, "text": "A hypolipoproteinemia that is characterized by an inablility to fully absorb dietary fats, cholesterol and fat-soluble vitamins, has_physical_basis_in an autosomal recessive disorder of lipid metabolism caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL)."} -{"_id": 8654, "text": "A Rubella virus infectious disease that results_in inflammation located_in brain, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom confusion, has_symptom drowsiness, has_symptom delirium, has_symptom convulsions, has_symptom cranial nerve palsies, and has_symptom coma."} -{"_id": 8657, "text": "A bone inflammation disease that involves rupture of the growth plate in children located_in tibia."} -{"_id": 8660, "text": "An alveolar soft part sarcoma that has not spread to other parts of the body."} -{"_id": 8663, "text": "A glycogen storage disease that has_material_basis_in deficiency of the lysosomal acid alpha-glucosidase enzyme resulting in damage to muscle and nerve cells due to an accumulation of glycogen in the lysosome."} -{"_id": 8666, "text": "A thymus cancer that derives_from epithelial cells located_in the thymus. The tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus."} -{"_id": 8669, "text": "A viral infectious disease that results_in infection causing reproductive failure of sows and respiratory problems of piglets and growing pigs, has_material_basis_in Porcine reproductive and respiratory syndrome virus, which is transmitted_by contact with feces, urine and semen of infected pigs, and transmitted_by fomites. The infection has_symptom stillborn piglets, has_symptom mummified fetuses, has_symptom premature farrowings, has_symptom weak-born pigs, and has_symptom pneumonia."} -{"_id": 8672, "text": "A thyroid gland disease which involves an underproduction of thyroid hormone."} -{"_id": 8675, "text": "A kidney cancer which is manifested in the kidney."} -{"_id": 8678, "text": "A sarcoma and malignant mediastinal mesenchymnal tumor that is located_in the mediastinum."} -{"_id": 8681, "text": "A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances."} -{"_id": 8684, "text": "A carcinoma that is located_in the inside of the abdomen."} -{"_id": 8687, "text": "A squamous cell carcinoma that contains squamous cells and gland-like cells."} -{"_id": 8690, "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons."} -{"_id": 8693, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems."} -{"_id": 8696, "text": "Ulcer of lower limbs is a chronic ulcer of skin where the ulcer is not a decubitus ulcer."} -{"_id": 8699, "text": "An epilepsy characterized by seizures triggered by visual stimuli that form patterns in space or time, such as flashing lights."} -{"_id": 8702, "text": "A personality disorder that is characterized by a pervasive psychological dependence on other people."} -{"_id": 8705, "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in penis, has_material_basis_in human papillomavirus (types 16 and 18), which cause malignant tumors in squamous epithelium of the penis."} -{"_id": 8708, "text": "An endocrine gland cancer that has_material_basis_in neuroendocrine cells."} -{"_id": 8711, "text": "A male reproductive organ cancer that derives_from epithelial cells of glandular origin."} -{"_id": 8714, "text": "An autosomal recessive disease characterized by oculocutaneous albinism, bleeding problems due to platelet storage pool defect, visual impairment and lysosomal accumulation of ceroid lipofuscin."} -{"_id": 8717, "text": "A parasitic protozoa infectious disease that involves infection of the large intestine by a protozoan parasite Dientamoeba fragilis. The symptoms include diarrhea, stomach pain and cramping, loss of appetite and weight, nausea, and fatigue."} -{"_id": 8720, "text": "A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues."} -{"_id": 8723, "text": "A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins."} -{"_id": 8726, "text": "A sarcoma and malignant neoplasm of urinary bladder that is located_in the bladder."} -{"_id": 8729, "text": "An ampulla of Vater cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 8732, "text": "An urethra cancer that derives_from epithelial cells of glandular origin."} -{"_id": 8735, "text": "An X-linked disease characterized by retardation, hyperactivity, hypotonia, broad thumbs, big first toes and a characteristic facial appearance including macrocephaly and has an X-linked recessive inheritance pattern."} -{"_id": 8738, "text": "A bartonellosis that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain."} -{"_id": 8741, "text": "A hypersensitivity reaction type II disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis."} -{"_id": 8744, "text": "An adenovirus infectious disease that results_in inflammation located_in meninges, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7 and has_symptom fever, has_symptom headache, has_symptom stiff neck, and has_symptom confusion."} -{"_id": 8747, "text": "A viral infectious disease results_in infection located_in skin, or located_in mucous membranes of the mouth, oesophagus, larynx or trachea of birds, has_material_basis_in Fowlpox virus, has_symptom lesions on the skin, has_symptom diphtheritic lesions in the upper parts of the digestive and respiratory tracts."} -{"_id": 8750, "text": "A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance."} -{"_id": 8753, "text": "An anus carcinoma that derives_from epithelial cells of glandular origin located_in the anal colloid."} -{"_id": 8756, "text": "A Herpesviridae infectious disease that results_in infection in children, has_material_basis_in Human herpesvirus 6 and has_material_basis_in Human herpesvirus 7."} -{"_id": 8759, "text": "A Kaposi's sarcoma that located_in older men of Italian or Eastern European Jewish origin. Kaposi's sarcoma results_in slow-growing lesions on the legs and feet."} -{"_id": 8762, "text": "An autosomal dominant disease that is characterized by \\nand has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers."} -{"_id": 8765, "text": "An upper respiratory tract disease involving inflammation of the nasal cavities and trachea caused by feline herpesvirus 1, of the family Herpesviridae in cats and especially young kittens that is characterized by sneezing, conjunctivitis with discharge, and nasal discharges."} -{"_id": 8768, "text": "A Flavivirus infectious disease that results_in infection in animals and humans, has_material_basis_in West Nile virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom nausea, has_symptom vomiting, has_symptom swollen lymph glands, or has_symptom skin rash on the chest, stomach and back."} -{"_id": 8771, "text": "A middle ear cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 8774, "text": "A lung disease characterized by inadequate gas exchange by the respiratory system."} -{"_id": 8777, "text": "An amino acid metabolic disorder that has_material_basis_in a mutation in the GATM gene resulting in deficiency of arginine:glycine amidinotransferase which then limits creatine synthesis."} -{"_id": 8780, "text": "A DNA virus infectious disease that results_in infection, has_material_basis_in ssDNA viruses, which possess single-stranded DNA."} -{"_id": 8783, "text": "A pancreatic ductal carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 8786, "text": "An autosomal recessive disease that is characterised by severe reduction or absence of the fibula and complex brachydactyly."} -{"_id": 8789, "text": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring."} -{"_id": 8792, "text": "A toxoplasmosis that involves infection of the heart with Toxoplasma gondii resulting in shortness of breath and constricting chest pain."} -{"_id": 8795, "text": "A corneal disease in which the cornea blends with sclera, resulting in clouding of the cornea."} -{"_id": 8798, "text": "A tyrosinemia that has_material_basis_in deficiency of 4-hydroxyphenylpyruvate dioxygenase disrupting the break down of tyrosine."} -{"_id": 8801, "text": "A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract."} -{"_id": 8804, "text": "A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails."} -{"_id": 8807, "text": "A musculoskeletal system cancer that is located_in connective tissue."} -{"_id": 8810, "text": "Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus."} -{"_id": 8813, "text": "An endodermal sinus tumor that occurs in adults."} -{"_id": 8816, "text": "A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability."} -{"_id": 8819, "text": "A DNA virus infectious disease that results_in infection, has_material_basis_in dsDNA retro-transcribing viruses, which possess double-stranded DNA genomes and replicate using reverse transcriptase."} -{"_id": 8822, "text": "An ancylostomiasis that is characterized by skin manifestations (cutaneous larva migrans) occuring due to migrating larvae of Ancylostoma braziliense in the upper epidermis. It is marked by the presence of erythematous, serpiginous and pruritic cutaneous eruptions."} -{"_id": 8825, "text": "A pericardial effusion that results from blood in the pericardial sac."} -{"_id": 8828, "text": "A leukemia that occurs in children."} -{"_id": 8831, "text": "A cervical adenosquamous carcinoma that is a rare form and is composed of cells with a glass-like cytoplasm."} -{"_id": 8834, "text": "A rickettsiosis that is caused by the genus Rickettsia. This infection results in pleural effusions and pulmonary edema."} -{"_id": 8837, "text": "A fruit allergy triggered by Ziziphus mauritiana plant fruit food product."} -{"_id": 8840, "text": "An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs."} -{"_id": 8843, "text": "A Charcot-Marie-Tooth disease characterized by demyelinating or axonal abnormalities that has_material_basis_in autosomal recessive inheritance."} -{"_id": 8846, "text": "A syndrome characterized by calcinosis, Raynaud's phenomeno, esophageal dysmotility, sclerodactyly and telangiectasia."} -{"_id": 8849, "text": "A B cell deficiency that is caused by mutations in the IGLL1 gene. Lambda 5 mutations an cause a block in B cell development at the transition between the pro-B cell and the pre-B cell stage."} -{"_id": 8852, "text": "An endocrine system disease that is located_in the parathyroid gland."} -{"_id": 8855, "text": "An adenofibroma that is composed_of epithelial ovarian tissue."} -{"_id": 8858, "text": "A mood disorder that involves the presence of a low mood almost daily over a span of at least two years."} -{"_id": 8861, "text": "A nervous system benign neoplasm that is located_in a sensory organ."} -{"_id": 8864, "text": "A respiratory system cancer that is located_in the bronchus."} -{"_id": 8867, "text": "A viral infectious disease that results_in infection in cattle, has_material_basis_in Bovine ephemeral fever virus, which is transmitted_by Culex, transmitted_by Anopheles, and transmitted_by Culicoides arthropods. The infection has_symptom fever, has_symptom stiffness, has_symptom lameness, has_symptom nasal discharge, has_symptom ocular discharge, has_symptom depression, has_symptom cessation of rumination, and has_symptom constipation."} -{"_id": 8870, "text": "A coccidioidomycosis that results_in pneumonia located_in lungs, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom pleuritic chest pain, has_symptom respiratory failure, has_symptom pleural effusion, and results_in_formation_of pulmonary nodules."} -{"_id": 8873, "text": "A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney."} -{"_id": 8876, "text": "A type of ALS with loci associated with the disease located_in chromosome 20."} -{"_id": 8879, "text": "A parasitic helminthiasis infectious disease that involves infection by metacestode larval stage (coenurus) of Taenia multiceps or Taenia serialis. Coenuri in the skin or subcutaneous tissue present as painless nodules, which manifest on the trunk, sclera, subconjuctiva, neck, shoulders, head and limbs. Coenuri in the central nervous system may cause headache, fever, vomiting, nerve palsies, jacksonian epilepsy, pachymeningitis, obstructive or communicating hydrocephalus, and intracranial arteritis with transient hemiparesis. Coenuri in the eye cause both intraocular and orbital infections."} -{"_id": 8882, "text": "A Human immunodeficiency virus infectious disease that results_in infection characterized by chronic diarrhea lasting longer than 1 month, without an identified infectious cause after thorough evaluation, in an HIV-positive individual, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. It is observed that HIV-infected individuals have histologic abnormalities of the gastrointestinal mucosa, malabsorption, and lymphocyte depletion causing diarrhea, increased gastrointestinal inflammation, increased intestinal permeability, and malabsorption of bile acid and vitamin B12."} -{"_id": 8885, "text": "A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss."} -{"_id": 8888, "text": "An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which affects bone growth and results_in a small body, hydrops fetalis, and abnormal ossification located_in vertebral column or located_in pelvis. The disease has_symptom enlarged abdomen."} -{"_id": 8891, "text": "An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system."} -{"_id": 8894, "text": "A thyroid medullary carcinoma that has_material_basis_in autosomal dominant inheritance."} -{"_id": 8897, "text": "An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland."} -{"_id": 8900, "text": "A sex differentiation disease that is characterized by the partial or complete inability of the cell to respond to androgens in individuals with a karyotype of 46,XY resulting in female physical traits but male genetic makeup."} -{"_id": 8903, "text": "A hematologic cancer that has_material_basis_in mast cells."} -{"_id": 8906, "text": "A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses)."} -{"_id": 8909, "text": "A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions."} -{"_id": 8912, "text": "An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease."} -{"_id": 8915, "text": "A spotted fever that has_material_basis_in Rickettsia heilongjiangensis, which is transmitted_by ticks (Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom maculopapular rash, and has_symptom regional adenopathy."} -{"_id": 8918, "text": "A Simplexvirus infectious disease that results_in inflammation located_in meninges, has_material_basis_in Human herpesvirus 2 and has_symptom headache, has_symptom fever, and has_symptom meningism."} -{"_id": 8921, "text": "A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health."} -{"_id": 8924, "text": "A viral infectious disease that results_in infection located_in eyes or located_in upper respiratory tract of domestic rabbits, has_material_basis_in Myxoma virus, which is transmitted_by mosquitos, transmitted_by biting flies or transmitted_by direct contact. The infection has_symptom conjunctivitis with a milky discharge from the inflamed eye and has_symptom breathing difficulties."} -{"_id": 8927, "text": "A dendritic cell sarcoma cancer that effects the follicular dendritic cells."} -{"_id": 8930, "text": "A type of ALS caused_by mutation located_in CHCHD10 gene located_in chromosome 22. It is characterized by adult onset of either frontotemporal dementia and/or amyotrophic lateral sclerosis."} -{"_id": 8933, "text": "A cancer that is classified by the type of cell from which it is derived."} -{"_id": 8936, "text": "A cell type benign neoplam that is composed_of epithelial tissue on papillae of vascularized connective tissue."} -{"_id": 8939, "text": "A carcinoma that derives_from transitional epithelial cells."} -{"_id": 8942, "text": "A eustachian tube disorder which involves inflammation of the mucous membrane of the cartilagenous portion of the eustachian tube caused by acute nasopharyngitis, infection from some pathogenic microbes or trauma of the tube."} -{"_id": 8945, "text": "A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis."} -{"_id": 8948, "text": "A spotted fever that has_material_basis_in Rickettsia conorii subsp indica, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities."} -{"_id": 8951, "text": "A dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking."} -{"_id": 8954, "text": "A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset."} -{"_id": 8957, "text": "An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions)."} -{"_id": 8960, "text": "A hypogonadism that is characterized by a progressive loss of germ cells on the developing gonads of an embryo."} -{"_id": 8963, "text": "A parasitic helminthiasis infectious diseasea that involves infection of the eyes in humans by nematode Thelazia callipaeda causing varying degrees of inflammation and lacrimation. In heavier infections, photophobia, edema, conjunctivitis, and blindness occurs."} -{"_id": 8966, "text": "A syndrome that involves pre-excitation of the ventricles due to an accessory pathway providing an abnormal electrical communication from the atria to the ventricles."} -{"_id": 8969, "text": "A cell type cancer that has_material_basis_in mesothelial tissue."} -{"_id": 8972, "text": "An upper respiratory tract disease characterized by the unusual growth of the adenoid tonsil; has_symptom snoring, has_symptom hyponasality, has_symptom otitis media with effusion, has symptom mouth breathing."} -{"_id": 8975, "text": "A primary systemic mycosis that results_in fungal infection located_in skin and located_in subcutaneous tissue through direct inoculation from wood splinters or hay, has_material_basis_in Sporothrix schenckii, a dimorphic fungus, which results_in_formation_of erythematous papulonodular lesions evolving into either smooth or verrucose painless nodules that may ulcerate and drain."} -{"_id": 8978, "text": "An aspergillosis that involves infection of the lung with Aspergillus, which causes pneumonia in people with an impaired immune system. The symptoms include wheezing, coughing and fever."} -{"_id": 8981, "text": "A pneumonia involving inflammation of the lungs caused by bacteria."} -{"_id": 8984, "text": "An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain."} -{"_id": 8987, "text": "An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response."} -{"_id": 8990, "text": "An autosomal disease characterized by varying degrees of deafness, minor defects in structures arising from the neural crest and pigmentation anomalies of the hair, the skin and/or the iris of both eyes."} -{"_id": 8993, "text": "An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism."} -{"_id": 8996, "text": "A connective tissue disease that is characterized by elongation and generalized tortuosity of the major arteries including the aorta."} -{"_id": 8999, "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Rotavirus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by fomites. The infection has_symptom fever, has_symptom vomiting, has_symptom diarrhea, and has_symptom abdominal pain."} -{"_id": 9002, "text": "A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal."} -{"_id": 9005, "text": "An opiate dependence that involves the continued use of heroin despite problems related to use of the substance."} -{"_id": 9008, "text": "A Retroviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Deltaretrovirus, which is transmitted_by congenital method, and transmitted_by sexual contact."} -{"_id": 9011, "text": "A Mumps virus infectious disease that results_in inflammation located_in brain, has_material_basis_in Mumps virus, which is transmitted_by contact with the oronasal secretions of an infected person. The infection has_symptom convulsions, has_symptom drowsiness, has_symptom rigidity of limbs, and has_symptom slurred speech."} -{"_id": 9014, "text": "An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle."} -{"_id": 9017, "text": "A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood."} -{"_id": 9020, "text": "A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment."} -{"_id": 9023, "text": "A Mumps virus infectious disease that results_in inflammation located_in meninges, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom severe headache, and has_symptom neck stiffness."} -{"_id": 9026, "text": "A viral infectious disease that results_in infection, has_material_basis_in DNA viruses, which have DNA as their genetic material and replicate using a DNA-dependent DNA polymerase."} -{"_id": 9029, "text": "A cervix disease characterized by a benign polyp on the surface of the cervical canal."} -{"_id": 9032, "text": "A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has_symptom blurred vision."} -{"_id": 9035, "text": "A colitis characterized by an overgrowth of Clostridium difficile bacteria."} -{"_id": 9038, "text": "A type of ALS caused_by mutation located_in VAPB gene located_in chromosome 20."} -{"_id": 9041, "text": "A nonsyndromic deafness characterized by an autosomal recessive inheritance mode."} -{"_id": 9044, "text": "An Epstein-Barr virus related lymphoma and is_a posttransplantation lymphoproliferative disorder that derives_from lymphocytes after organ transplant, has_material_basis_in Human herpesvirus 4."} -{"_id": 9047, "text": "An ectothrix infectious disease that results_in anthropophilic fungal infection located_in skin and located_in hair, has_material_basis_in Microsporum ferrugineum."} -{"_id": 9050, "text": "A cheilitis characterized by inflammation of one or both of the corners of the mouth."} -{"_id": 9053, "text": "A gastrointestinal system benign neoplasm that is located_in the intestine."} -{"_id": 9056, "text": "A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells."} -{"_id": 9059, "text": "A cecum cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 9062, "text": "An endocrine system disease that is located_in the thyroid."} -{"_id": 9065, "text": "A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions."} -{"_id": 9068, "text": "A testicular cancer that has_material_basis_in germ cells."} -{"_id": 9071, "text": "A commensal streptococcal infectious disease that involves infection of the pharynx and sometimes the larynx and tonsils. It is caused by Group A Streptococcus bacteria. The common symptoms include fever, sore throat, headache, stomach ache, nausea, or chills."} -{"_id": 9074, "text": "A parasitic protozoa infectious disease that involves infection caused by euglenozoans, which are single-celled flagellates."} -{"_id": 9077, "text": "A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes."} -{"_id": 9080, "text": "A lice infestation that is a cutaneous condition caused by parasitic infestation of body lice Pediculus humanus corporis, which feed on the human blood. Body lice can spread epidemic typhus, trench fever, and louse-borne relapsing fever."} -{"_id": 9083, "text": "A chronic purulent otitis media which involves perforation in the attic region (pars flaccida of the tympanic membrane) or at the posterosuperior margin, with in-growth of squamous epithelium into the middle ear. This is caused as a result of poor ventilation of the middle ear and episodes of infection."} -{"_id": 9086, "text": "An esophageal cancer that arises from transformed cells of mesenchymal origin sarcoma and located_in the esophagus."} -{"_id": 9089, "text": "A disease of mental health where symptoms are deliberately produced, feigned or exaggerated in order to falsely demonstrate the presence of an illness."} -{"_id": 9092, "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum."} -{"_id": 9095, "text": "A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year."} -{"_id": 9098, "text": "A brain glioma that has_material_basis_in oligodendrocytes."} -{"_id": 9101, "text": "A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite."} -{"_id": 9104, "text": "An intestinal disease characterized by inflammation located_in all parts of digestive tract."} -{"_id": 9107, "text": "A sarcoma that is located_in the gallbladder."} -{"_id": 9110, "text": "An Enterovirus infectious disease that results_in inflammation located_in heart, has_material_basis_in Human enterovirus B, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions."} -{"_id": 9113, "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from two germinal layers of tissue."} -{"_id": 9116, "text": "A bone carcinoma that derives_from squamous epithelial cells."} -{"_id": 9119, "text": "An African histoplasmosis that results_in inflammation located_in endocardium, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom murmurs, has_symptom peripheral edema, has_symptom pulmonary rales, has_symptom petechia and has_symptom skin lesions."} -{"_id": 9122, "text": "A retinoblastoma that refers to bilateral retinoblastoma associated with an intracranial primitive neuroectodermal tumor located_in the pineal or suprasellar region."} -{"_id": 9125, "text": "A tic disorder that consists of multiple motor and/or phonic tics with duration of at least 4 weeks, but less than 12 months."} -{"_id": 9128, "text": "A hemangiopericytoma which is manifested in the central nervous system."} -{"_id": 9131, "text": "A pigmentation disease characterized by reticulate hyper- and hypo-pigmentated macules in a generalized distribution."} -{"_id": 9134, "text": "A thymic carcinoma that derives_from squamous cells and gland-like cells."} -{"_id": 9137, "text": "A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain."} -{"_id": 9140, "text": "An osteochondrodysplasia that has_material_basis_in a mutation in chromosome 17 which results_in bowing in the located_in tibia or located_in femur."} -{"_id": 9143, "text": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 9146, "text": "A pulmonary tuberculosis characterized by bronchial compression and obstruction as a result of enlarged lymph nodes of the primary complex or by infiltration of the wall of the bronchi by caseous lymph nodes."} -{"_id": 9149, "text": "An endocrine gland cancer located_in the pancreas."} -{"_id": 9152, "text": "A tularemia that results_in painful regional lymphadenopathy and an ulcerated skin lesion."} -{"_id": 9155, "text": "A small intestine sarcoma that affects the involuntary smooth muscles of the small intestines."} -{"_id": 9158, "text": "An exostosis that has_material_basis_in a mutation on the genes EXT1, EXT2 and EXT3 which results_in multiple bony spurs throughout a child's growth."} -{"_id": 9161, "text": "An urticaria induced by stroking of the skin."} -{"_id": 9164, "text": "A urinary system disease that is located_in the kidney."} -{"_id": 9167, "text": "A strongyloidiasis that involves infection of intestine with Strongyloides stercoralis, which results in abdominal pain, diarrhea, ileus, massive gastrointestinal bleeding, severe malabsorption, and peritonitis."} -{"_id": 9170, "text": "A synostosis that results_in the fusion of two or more digits."} -{"_id": 9173, "text": "A lymphoblastic leukemia that is characterized by over production of lymphoblasts."} -{"_id": 9176, "text": "An extracranial neuroblastoma that has_material_basis_in immature nerve cells."} -{"_id": 9179, "text": "A syndrome characterized by defects of the scalp (aplasia cutis congenita), abnormalities of the fingers, toes, arms and legs."} -{"_id": 9182, "text": "An actinomycosis that involves invasion and infiltration located_in brain, has_material_basis_in Actinomyces israelii. The infection results_in_formation_of brain abscess."} -{"_id": 9185, "text": "A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning."} -{"_id": 9188, "text": "A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia."} -{"_id": 9191, "text": "An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum."} -{"_id": 9194, "text": "A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis."} -{"_id": 9197, "text": "A gamma-amino butyric acid metabolism disorder that is characterized by a defect in the gene coding for gamma-aminobutyrate transaminase, which is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde."} -{"_id": 9200, "text": "An autosomal recessive disease that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB)."} -{"_id": 9203, "text": "A filarial elephantiasis that involves parasitic infection by the nematode Brugia timori, which inhabits the lymphatics. The symptoms include fever and chronic lymphedema."} -{"_id": 9206, "text": "A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp."} -{"_id": 9209, "text": "An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood."} -{"_id": 9212, "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine, liver and lungs caused by Capillaria species."} -{"_id": 9215, "text": "A thyroid gland disease that involves an abnormal enlargement of the thyroid gland."} -{"_id": 9218, "text": "A parasitic protozoa infectious disease that involves infection caused by amoeboid protozoa."} -{"_id": 9221, "text": "A neurodegenerative disease that is characterized by intraneuronal inclusions of mutant neuroserpin resulting in progressive encephalopathy, dementia and seizures and has_material_basis_in a mutation in the SERPINI1 gene inherited in an in autosomal dominant pattern."} -{"_id": 9224, "text": "A leiomyosarcoma and sarcoma of the anus that is located_in the anus."} -{"_id": 9227, "text": "A Pseudomonas infectious disease that is caused by a Gram-negative bacterium Pseudomonas aeruginosa resulting in pulmonary edema. This bacterium releases immunogenic bacterial components that can gain access to airway epithelium and immune cells in the lung thus causing airway inflammation. P. aeruginosa is the common cause of hospital acquired and ventilator-associated pneumonias."} -{"_id": 9230, "text": "A lipodystrophy and is_a Human immunodeficiency virus infectious disease that is characterized by loss of subcutaneous fat, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. Anti-retroviral medications are also associated with the disease. The infection has_symptom fat loss in face, buttocks, arms, legs."} -{"_id": 9233, "text": "A skin disease characterized_by growth of keratin on the skin or mucous membranes."} -{"_id": 9236, "text": "A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles."} -{"_id": 9239, "text": "An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other."} -{"_id": 9242, "text": "A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells."} -{"_id": 9245, "text": "A viral infectious disease that results_in inflammation located_in brain and located_in spinal cord of pigs, has_material_basis_in Porcine teschovirus, which is transmitted_by ingestion of contaminated food, and transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom anorexia, has_symptom depression, has_symptom incoordination, has_symptom paralysis, has_symptom muscle tremors, has_symptom stiffness, has_symptom nystagmus, has_symptom seizures, and has_symptom loss of the voice."} -{"_id": 9248, "text": "A carcinoma that derives_from the cells that line an organ."} -{"_id": 9251, "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the liver of a variety of wild and domestic ruminants by Fascioloides magna."} -{"_id": 9254, "text": "A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles."} -{"_id": 9257, "text": "A carcinoma in situ that is characterized by the spread of cancer in skin and the lack of invasion of surrounding tissues."} -{"_id": 9260, "text": "A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. The rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous."} -{"_id": 9263, "text": "An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in undeveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull."} -{"_id": 9266, "text": "A viral infectious disease that results_in infection in cattle, has_material_basis_in Rinderpest virus, which is transmitted_by direct contact with an infected animal, or transmitted_by ingestion of contaminated water. The infection has_symptom fever, has_symptom nasal and eye discharge, and results_in_formation_of erosions in the mouth, the lining of the nose and the genital tract."} -{"_id": 9269, "text": "A sleep disorder that involves involuntary limb movement during sleep."} -{"_id": 9272, "text": "An inflammatory bowel disease that is characterized by patchy areas of inflammation located_in jejunum, has_symptom abdominal pain, has_symptom diarrhea, has_symptom cramps and has_symptom formation of fistulas."} -{"_id": 9275, "text": "A myeloid leukemia that is characterized by over production of white blood cells."} -{"_id": 9278, "text": "A dsDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Poxviridae viruses."} -{"_id": 9281, "text": "A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face."} -{"_id": 9284, "text": "An angiosarcoma and hemangioma of skin and malignant skin vascular tumor and sarcoma of skin that is located_in the skin and results_in an enlarged bruise (a blue-black nodule) and an unhealed ulceration."} -{"_id": 9287, "text": "A carcinosarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium."} -{"_id": 9290, "text": "A Parkinson's disease caused by mutation in the alpha-synuclein gene, SNCA, on chromosome 4q22.1."} -{"_id": 9293, "text": "A pulmonary valve disease that occurs when the pulmonary valve is not strong enough to prevent backflow into the right ventricle. If it is secondary to pulmonary hypertension it is referred to as a Graham Steell murmur."} -{"_id": 9296, "text": "A cell type benign neoplasm that is composed of lipocytes."} -{"_id": 9299, "text": "A myopathy characterized by abnormally located nuclei in skeletal muscle cells. The nuclei are located in the center of the cell, instead of their normal location at the periphery."} -{"_id": 9302, "text": "A Varicellovirus infectious disease that results_in inflammation located_in external ear canal, has_material_basis_in Human herpesvirus 3, has_symptom pain in the outer ear, and has_symptom ear discharge."} -{"_id": 9305, "text": "A parasitic ectoparasitic infectious disease that involves infestation of lice, which are blood-feeding ectoparasitic insects of the order Phthiraptera."} -{"_id": 9308, "text": "A histoplasmosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains."} -{"_id": 9311, "text": "A DNA virus infectious disease that results_in infection, has_material_basis_in dsDNA viruses, which possess double-stranded DNA."} -{"_id": 9314, "text": "An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates."} -{"_id": 9317, "text": "A mixed neoplasm that consist of epithelial tissue, and stromal or mesenchymal tissue."} -{"_id": 9320, "text": "A lung small cell carcinoma that is characterized as a multiphasic lung cancer comprised of a mixture of small cell and non-small cell lung carcinoma cells."} -{"_id": 9323, "text": "A mucopolysaccharidosis characterized by a deficiency in hyaluronidase."} -{"_id": 9326, "text": "A primary bacterial infectious disease that is a sexually transmitted infection located_in skin of the genitals, has_material_basis_in Haemophilus ducreyi, which is transmitted_by sexual contact. The infection has_symptom painful and soft ulcers."} -{"_id": 9329, "text": "An amino acid metabolic disorder that iis caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum."} -{"_id": 9332, "text": "A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures."} -{"_id": 9335, "text": "An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland."} -{"_id": 9338, "text": "A spondyloepimetaphyseal dysplasia that is characterized by short stature, short and bowed lower limbs, mild brachydactyly, kyphoscoliosis, abnormal gait, enlarged knee joints, precocious osteoarthropathy, and normal intelligence."} -{"_id": 9341, "text": "A primary Campylobacter infectious disease that involves inflammation of the stomach and intestines caused by Campylobacter jejuni infection, which is characterized by diarrhea (may be bloody), abdominal pain, fever and vomiting."} -{"_id": 9344, "text": "A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever."} -{"_id": 9347, "text": "A muscular disease that is located_in the diaphragm."} -{"_id": 9350, "text": "A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues."} -{"_id": 9353, "text": "A cardiovascular cancer that is located_in blood vessels."} -{"_id": 9356, "text": "A disease that involves any biological process (GO:0008150) specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms."} -{"_id": 9359, "text": "A Paramyxoviridae infectious disease that results_in infection in birds and rarely humans, has_material_basis_in Avulavirus, which is transmitted_by direct contact with droppings and secretions from the nose, mouth, and eyes."} -{"_id": 9362, "text": "An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus."} -{"_id": 9365, "text": "A nasopharyngeal disease which involves inflammation of the nasal passages and upper part of the pharynx."} -{"_id": 9368, "text": "A sublingual gland cancer that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ."} -{"_id": 9371, "text": "A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly."} -{"_id": 9374, "text": "A disease by infectious agent that results_in infection, has_material_basis_in Viruses."} -{"_id": 9377, "text": "A HIV encephalopathy that results_in inflammation located_in white matter of neuraxis, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom weakness, has_symptom paralysis, has_symptom vision loss, has_symptom impaired speech, and has_symptom cognitive deterioration."} -{"_id": 9380, "text": "A central nervous system disease that involves encephalitis which occurs along with meningitis."} -{"_id": 9383, "text": "An autosomal dominant disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins."} -{"_id": 9386, "text": "A selective immunoglobulin deficiency disease that is the result of a deficiency of immunoglobulin A (IgA), an antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract."} -{"_id": 9389, "text": "An ectothrix infectious disease that results_in zoophilic fungal infection located_in scalp and located_in hair, has_material_basis_in Trichophyton equinum."} -{"_id": 9392, "text": "A candidiasis that involves inflammation of the gastric mucosa caused by Candida albicans infection. The symptoms include dyspepsia, gastric ulcers, gastric perforations, nausea and vomiting."} -{"_id": 9395, "text": "An impulse control disorder that involves abnormalities in memory, social and sexual functioning and idiosyncratic behaviors resulting from damage from trauma or infection to both temporal lobes causing individuals to put objects in their mouths and engage in inappropriate sexual behavior."} -{"_id": 9398, "text": "A bile duct cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 9401, "text": "A Nidovirales infectious disease that results_in infection in animals, has_material_basis_in Arteriviridae viruses."} -{"_id": 9404, "text": "A keratosis characterized by abnormal thickening of the palms and the soles."} -{"_id": 9407, "text": "A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body."} -{"_id": 9410, "text": "A disease by infectious agent that results_in infection, has_material_basis_in Bacteria."} -{"_id": 9413, "text": "A mansonelliasis that involves parasitic infection by the nematode Mansonella streptocerca, which resides in the dermis and subcutaneous tissue causing pruritus, papular eruptions and pigmentation changes. Midges transmit the disease."} -{"_id": 9416, "text": "A non-Hodgkin lymphoma that has_material_basis_in mucosal tissue involved in antibody production."} -{"_id": 9419, "text": "An urea cycle disorder that involves arginase deficiency resulting in elevated levels of plasma arginine."} -{"_id": 9422, "text": "A T-cell leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions."} -{"_id": 9425, "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine in horses by the nematode Strongylus equinus."} -{"_id": 9428, "text": "A Cytomegalovirus infectious disease that results_in inflammation, located_in lung, has_material_basis_in Human herpesvirus 5, a member of a group of herpes-type viruses especially in people who have a suppressed immune system and has_symptom cough, has_symptom fatigue, has_symptom shortness of breath, and has_symptom hypoxemia. Cytomegalovirus infection can be demonstrated microscopically by the detection of intranuclear inclusion bodies."} -{"_id": 9431, "text": "An intestinal infectious disease that involves inflammation of the intestines, especially colon, due to chemical irritants, bacteria, protozoa, or parasitic worms, which results in severe diarrhea with passage of mucus and blood."} -{"_id": 9434, "text": "A mitochondrial metabolism disease that has material basis in mutation in the ATPAF2 gene on chromosome 17p11."} -{"_id": 9437, "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzymes galactose 6-sulfate sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain."} -{"_id": 9440, "text": "A Chagas disease that involves deterioration of the function of the myocardium caused due to Trypanosoma cruzi infection, which leads to heart rhythm abnormalities and may result in sudden death."} -{"_id": 9443, "text": "An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation."} -{"_id": 9446, "text": "A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly."} -{"_id": 9449, "text": "A chronic myeloproliferative and megakaryocytic tumor and thrombocytosis that is a rare chronic disorder that results_in the overproduction of platelets."} -{"_id": 9452, "text": "An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 9455, "text": "A severe combined immunodeficiency that is the result of a mutation on Chromosome 6 RAG2 gene involving genetic rearrangement of both the T- and B-lymphocyte receptor genes."} -{"_id": 9458, "text": "A tuberculosis that occurs at body sites other than the lung."} -{"_id": 9461, "text": "A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia."} -{"_id": 9464, "text": "A neonatal diabetes mellitus characterized by hyperglycemia during the neonatal period that remits during infancy but recurs in later life in most patients."} -{"_id": 9467, "text": "An ischemic bone disease the has_material_basis_in nitrogen embolization located_in bone."} -{"_id": 9470, "text": "An idiopathic generalized epilepsy characterized by onset of multiple seizure types in the first few years of life and associated with poor prognosis. Affected individuals have cognitive regression and intellectual disability."} -{"_id": 9473, "text": "A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning."} -{"_id": 9476, "text": "A dementia and a synucleinopathy that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities."} -{"_id": 9479, "text": "An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac."} -{"_id": 9482, "text": "An autosomal recessive genetic disease characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease."} -{"_id": 9485, "text": "An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected."} -{"_id": 9488, "text": "An autosomal recessive disease characterized by permanent parathyroid hormone (PTH) deficiency, hypocalcemia, hyperphosphatemia, facial anomalies, and psychomotor retardation; it is seen among children born to consanguineous couple of Arab ethnicity."} -{"_id": 9491, "text": "A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them."} -{"_id": 9494, "text": "A lung disease with an unknown etiology affecting the lungs which results in bleeding from tiny alveolar capillaries. Examination of sputum and bronchoalveolar lavage fluid can disclose hemosiderin-laden alveolar macrophages (siderophages), and the lung biopsy shows numerous siderophages in the alveoli. Alveolar hemorrhage is characterized by hemoptysis, dyspnea, alveolar infiltrates on chest radiograph, and various degrees of anaemia. Following a bleeding episode, the alveolar macrophages convert the hemoglobin's iron into hemosiderin within 36-72h."} -{"_id": 9497, "text": "An anogenital venereal wart that results_in infection located_in cervix, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct sexual contact with the skin of an infected partner. The infection has_symptom cervical warts."} -{"_id": 9500, "text": "A methylmalonic acidemia that is characterized by the accumulation of cobalamin in lysosomes which is then unable to synthesize the cofactors adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl)."} -{"_id": 9503, "text": "A melanoma that has_material_basis_in melanocytes located_in mucosal membranes lining the respiratory, gastrointestinal and urogenital tract."} -{"_id": 9506, "text": "A viral infectious disease that results in increased proliferation of affected CD4 lymphocytes, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The person infected with HTLV-1 eventually develop an often rapidly fatal leukemia, while others will develop a debilitative myelopathy, uveitis, infectious dermatitis, or another inflammatory disorder."} -{"_id": 9509, "text": "A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings."} -{"_id": 9512, "text": "A hypersensitivity reaction type II disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes."} -{"_id": 9515, "text": "A non-suppurative otitis media and eustachian tube disorder in which the tube is either too narrow or too wide. It can also be cuased by nasal inflammation which leads to inflammatory swelling and obstruction of the eustachian tube, which, in turn, leads to increased negative pressure in the middle ear and improper ventilation."} -{"_id": 9518, "text": "An articulation disorder characterized by involuntary sound repetition and disruption or blocking of speech."} -{"_id": 9521, "text": "A Mononegavirales infectious disease that results_in infection in animals and humans, has_material_basis_in Paramyxoviridae viruses."} -{"_id": 9524, "text": "An amino acid metabolic disorder that involves the formation of cystine stones in the kidneys, ureter, and bladder."} -{"_id": 9527, "text": "An agnosia that is a loss of the ability to distinguish the fingers on the hand."} -{"_id": 9530, "text": "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle."} -{"_id": 9533, "text": "A bone cancer that is manifested in the long bones of the lower limb."} -{"_id": 9536, "text": "A hemangiopericytoma that is manifested in the breast."} -{"_id": 9539, "text": "A carcinoma that results from uncontrolled proliferation of transformed cells of epithelial origin, which has no epithelial structural differentiation."} -{"_id": 9542, "text": "A rectum sarcoma that is located_in the rectum in which the cancer cells are thought to arise from skeletal muscle progenitors."} -{"_id": 9545, "text": "A parietal lobe neoplasm that has_material_basis_in cells lining the ventricles of the brain."} -{"_id": 9548, "text": "An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms."} -{"_id": 9551, "text": "A mitochondrial metabolism disease that has_material_basis_in a mutation in the SCO2 gene which encodes a COX assembly factor and results in deficiency of cytochrome c oxidase."} -{"_id": 9554, "text": "An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism."} -{"_id": 9557, "text": "A chronic conjunctivitis that is an inflammation of the conjunctiva involing red, itchy, and watery eyes a resulting from an exposure to an allergen or an irritant."} -{"_id": 9560, "text": "A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum."} -{"_id": 9563, "text": "An autoimmune disease that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels."} -{"_id": 9566, "text": "A hypersensitivity reaction type I disease located in the gastrointestinal tract."} -{"_id": 9569, "text": "A gastrointestinal system cancer that is located_in the esophagus."} -{"_id": 9572, "text": "A jaw cancer and mandibular disease that affects your lower jawbone."} -{"_id": 9575, "text": "A snail allergy triggered by Turbo cornutus."} -{"_id": 9578, "text": "A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively."} -{"_id": 9581, "text": "An appendix cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 9584, "text": "A disease of anatomical entity that is located_in reproductive system organs."} -{"_id": 9587, "text": "A uveal cancer that has_material_basis_in uvea pigment cells."} -{"_id": 9590, "text": "A skin disease that is located_in the sebaceous gland."} -{"_id": 9593, "text": "A sarcoma that is located_in the skin or located_in tissues that line or cover internal organs and that contains long spindle-shaped cells."} -{"_id": 9596, "text": "A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy."} -{"_id": 9599, "text": "A non-suppurative otitis media and eustachian tube disorder which is persistent and long-lasting."} -{"_id": 9602, "text": "A peripheral nervous system neoplasm that is located_in the connective tissue surrounding nerves."} -{"_id": 9605, "text": "A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes."} -{"_id": 9608, "text": "Collecting duct carcinoma is a renal cell carcinoma described as a rare and aggressive type of renal cell carcinoma. The cancerous cells form irregular tubes inside the tumor. Collecting duct carcinoma is more common among young people and unfortunately is diagnosed in most cases when the cancer has metastasized (spread inside the body)."} -{"_id": 9611, "text": "An X-linked disease resulting from a deficiency in N-terminal acetyltransferase, characterized by postnatal growth failure with severe delays and dysmorphic features in boys."} -{"_id": 9614, "text": "An Escherichia coli intestinal infectious disease that involves infection of the intestine caused by a serological subgroup of Escherichia coli called enteropathogenic Escherichia coli (EPEC), which has a plasmid-encoded protein referred to as EPEC adherence factor that enables localized adherence of bacteria to intestinal cells and a non fimbrial adhesin designated intimin, which is an outer membrane protein that mediates the final stages of adherence. EPEC induce a profuse watery (sometimes bloody) diarrhea."} -{"_id": 9617, "text": "A colorectal cancer that is located_in the rectum."} -{"_id": 9620, "text": "An autosomal dominant disease characterized by familial granulomatous arthritis, uveitis and skin granulomas caused_by NOD2/CARD15 mutations."} -{"_id": 9623, "text": "A B-cell lymphocytic neoplasm characterized by an uncontrolled increase of B-cells."} -{"_id": 9626, "text": "An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles."} -{"_id": 9629, "text": "A labyrinthine disease characterized by an abnormal bone growth in the middle ear."} -{"_id": 9632, "text": "A Human immunodeficiency virus infectious disease that results_in infection with mild symptoms, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom swollen lymph glands, has_symptom fever, has_symptom diarrhea, and has_symptom weight loss."} -{"_id": 9635, "text": "A cognitive disorder that involves an excessive, irrational dread of everyday situations."} -{"_id": 9638, "text": "A rickets that results has_material_basis in X-linked mutations in the PHEX gene that lead to increased circulating levels of FGF-23, a phosphate-regulating hormone (phosphatonin), that leads to reduced renal phosphate reabsorption and consequently abnormal bone mineralization."} -{"_id": 9641, "text": "A cervical carcinosarcoma that is located_in the cervix."} -{"_id": 9644, "text": "A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} -{"_id": 9647, "text": "A cecum carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 9650, "text": "An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation."} -{"_id": 9653, "text": "A rhabdomyosarcoma and sarcoma of bile duct that is located_in the bile duct."} -{"_id": 9656, "text": "An interstitial nephritis endemic to the regions along the Danube river, in the modern countries of Croatia, Bosnia and Herzegovina, Serbia, Romania and Bulgaria."} -{"_id": 9659, "text": "A factitious disorder that involves a care giver's deliberate exaggeration, fabrication, and/or induce physical, psychological, behavioral, and/or mental health problems in others."} -{"_id": 9662, "text": "A myiasis that involves parasitic infestation of Oestrus ovis larvae in the eye causing severe irritation, edema, and pain."} -{"_id": 9665, "text": "A renal pelvis carcinoma that derives_from epithelial cells of glandular origin."} -{"_id": 9668, "text": "An apocrine sweat gland cancer that derives_from epithelial cells of glandular origin."} -{"_id": 9671, "text": "A Charcot-Marie-Tooth disease that is characterized by pyramidal features including extensor plantar responses, mild increase in tone, and preserved or increased reflexes but no spastic gait."} -{"_id": 9674, "text": "An adrenal gland cancer that is located_in the adrenal medulla."} -{"_id": 9677, "text": "A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting."} -{"_id": 9680, "text": "An electroclinical syndrome with onset in adolescence and adulthood."} -{"_id": 9683, "text": "A bone inflammation disease that is located_in joint."} -{"_id": 9686, "text": "An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face."} +{"_id": "2", "text": "A cerebral ventricle cancer that is located_in the plexus located_in the ventricles of the brain."} +{"_id": "5", "text": "An angiosarcoma and hemangioma of intra-abdominal structure and malignant soft tissue neoplasm of the spleen that results_in a nonhematolymphoid malignant neoplasm of the spleen."} +{"_id": "8", "text": "A endometrial cancer that is located_in the tissue lining the uterus."} +{"_id": "11", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia."} +{"_id": "14", "text": "An inherited metabolic disorder that involves mitochondrial metabolism dysfunction."} +{"_id": "17", "text": "A non-syndromic intellectual disability characterized by a X-linked inheritance pattern."} +{"_id": "20", "text": "An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infection."} +{"_id": "23", "text": "A tularemia that results_in inflammation of eye and swelling of lymph glands in front of the ear."} +{"_id": "26", "text": "A opisthorchiasis that involves parasitic infection of the liver, biliary ducts, pancreas and pancreatic ducts by Opisthorchis felineus. The symptoms include fever, general malaise, skin rash, gastrointestinal disturbances, severe anemia and liver damage."} +{"_id": "29", "text": "A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing."} +{"_id": "32", "text": "An ectothrix infectious disease that results_in zoophilic fungal infection located_in hair, located_in skin, and located_in nail, has_material_basis_in Microsporum canis."} +{"_id": "35", "text": "A genetic disease associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia."} +{"_id": "38", "text": "A commensal Escherichia coli infectious disease that is caused by Escherichia coli. The disease results from proliferation of aspirated organisms in terminal airways, usually at multiple sites in the lung. Multifocal area of consolidation result and terminal airways and alveoli are filled with proteinaceous fluid, fibrin, neutrophils, and macrophages."} +{"_id": "41", "text": "An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries."} +{"_id": "44", "text": "A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye."} +{"_id": "47", "text": "An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision."} +{"_id": "50", "text": "A muscle tissue disease characterized by congenital joint contractures of hand and feet."} +{"_id": "53", "text": "A purpura characterized blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation. It is often fatal."} +{"_id": "56", "text": "A smallpox that results_in severe infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions."} +{"_id": "59", "text": "An autosomal dominant disease that is characterized by predisposition to hamartomatous benign polyps in the gastrointestinal tract, specifically in the stomach, small intestine, colon, and rectum."} +{"_id": "62", "text": "A Human immunodeficiency virus infectious disease that results_in inflammation located_in wall of artery of the central nervous system, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2."} +{"_id": "65", "text": "An autosomal dominant disease characterized by abnormalities of the front part of the eye, the anterior segment."} +{"_id": "68", "text": "A breast myoepithelial neoplasm that affects the breast and is characterized by biphasic proliferation of both epithelial and myoepithelial cells."} +{"_id": "71", "text": "A genetic disease that is characterized by underdevelopment of the tips of fingers or toes, underdevelopment or abscense of finger or toe nails and developmental disability."} +{"_id": "74", "text": "A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinomycetales bacteria, which are part of the normal human flora."} +{"_id": "77", "text": "A spotted fever that has_material_basis_in Rickettsia rickettsii, which is transmitted_by ticks (Dermacentor variabilis and Dermacentor andersoni). The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, and has_symptom maculopapular rash progressing into papular or petechial rash."} +{"_id": "80", "text": "A viral infectious disease that results_in infection in pigs, has_material_basis_in African swine fever virus, which is transmitted_by contact with sick animals or transmitted_by ingestion of contaminated food containing infected meat, or transmitted_by ticks of the genus Ornithodoros. The infection has_symptom fever, has_symptom reddening of the skin, has_symptom leukopenia, and has_symptom thrombocytopenia."} +{"_id": "83", "text": "An X-linked disease that is caused by mutation in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement."} +{"_id": "86", "text": "A connective tissue benign neoplasm that is located_in bone."} +{"_id": "89", "text": "A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term."} +{"_id": "92", "text": "A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both."} +{"_id": "95", "text": "A duodenum cancer that derives_from epithelial cells of glandular origin."} +{"_id": "98", "text": "A acute conjunctivitis which involves a fibrin-rich exudate formation on the surface of the conjunctiva. Infectious causes of pseudomembranes include Corynebacterium diphtheriae, streptococci, pneumococci, herpes simplex virus, adenovirus, Chlamydia and gonococci. Other causes include chemical (alkali) irritants, erythema multiforme, and ocular pemphigoid."} +{"_id": "101", "text": "A plasma protein metabolism disease that has_material_basis_in defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells."} +{"_id": "104", "text": "A ethmoid sinusitis which lasts for 12 weeks or more."} +{"_id": "107", "text": "A viral infectious disease that results_in necrosis located_in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has_symptom severe chest pain, has_symptom fever, has_symptom malaise, has_symptom pleuritis, and has_symptom headache."} +{"_id": "110", "text": "A pneumonia which has a multifactorial etiology and develops as a result of complex interactions between environmental factors, host factors, and pathogens leading to pulmonary lesions caused by various micro organisms ( essentially viruses and bacteria). Environmental factors (eg, weaning, transport, commingling, crowding, and inadequate ventilation) serve as stressors that adversely affect the immune and nonimmune defense mechanisms of the host. In addition, certain environmental factors (eg, crowding and inadequate ventilation) can enhance the transmission of infectious agents among animals."} +{"_id": "113", "text": "An arthritis that has_material_basis_in uric acid crystal deposits located_in joint."} +{"_id": "116", "text": "A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection."} +{"_id": "119", "text": "A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems."} +{"_id": "122", "text": "A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions."} +{"_id": "125", "text": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells."} +{"_id": "128", "text": "An inflammatory bowel disease characterized by inflammation located_in colon only, has_symptom diarrhea, has_symptom rectal bleeding, has_symptom skin lesions and has_symptom formation of ulcers, fistulas and abscesses around the anus."} +{"_id": "131", "text": "A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting."} +{"_id": "134", "text": "A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding."} +{"_id": "137", "text": "A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands."} +{"_id": "140", "text": "A muscular disease in which the muscle fibers do not function resulting in muscular weakness."} +{"_id": "143", "text": "A labyrinthitis which is a bacterial infectious disease of the inner ear, often causing deafness and loss of vestibular function. This is caused when bacteria spread to the inner ear during the course of severe acute otitis media, purulent meningitis, or an enlarging cholesteatoma."} +{"_id": "146", "text": "A uterine Corpus sarcoma that has recurred after it has been treated."} +{"_id": "149", "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from precursor cells called blast cells."} +{"_id": "152", "text": "An agnosia that is a loss of the ability to orient parts of the body."} +{"_id": "155", "text": "A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation."} +{"_id": "158", "text": "An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy."} +{"_id": "161", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Echinostoma species. The symptoms include nausea, vomiting, diarrhea, fever and abdominal pain."} +{"_id": "164", "text": "A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation."} +{"_id": "167", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop."} +{"_id": "170", "text": "A West Nile virus infectious disease that has_material_basis_in West Nile virus, which can cause meningitis, encephalitis, acute laccid paralysis, Parkingsonian-like conditions or movement disorder."} +{"_id": "173", "text": "A heart sarcoma that is a soft tissue sarcoma located in the heart."} +{"_id": "176", "text": "A medulloblastoma that is characterized by cells that are larger than would be normally expected."} +{"_id": "179", "text": "An epidemic typhus that is a mild form of the disease, which recurs in someone after a long period of latency due to immunosuppression, malnutrition or other illnesses."} +{"_id": "182", "text": "A mixed germ cell cancer that is located_in the testis."} +{"_id": "185", "text": "A peripheral primitive neuroectodermal tumor that is located_in bone."} +{"_id": "188", "text": "An organ system benign neoplasm located_in the integumentary system organs."} +{"_id": "191", "text": "An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur."} +{"_id": "194", "text": "A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue."} +{"_id": "197", "text": "A vein disease that is characterized by impaired flow of blood through the veins."} +{"_id": "200", "text": "An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms."} +{"_id": "203", "text": "A peripheral neuropathy that involves damage to nerves of the peripheral nervous system."} +{"_id": "206", "text": "A syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows, medially flaring and sparse in the middle part, hypertelorism, deep set but large eyes, large and uplifted ear lobes, with a central depression, saddle nose with prominent rounded nasal tip, prominent columella, open mouth, with M-shaped upper lip, frequent smiling, and a prominent but narrow and triangular pointed chin), moderate-to-severe intellectual deficiency, epilepsy and variable congenital malformations including Hirschsprung disease, genitourinary anomalies (in particular hypospadias in males), congenital heart defects, agenesis of the corpus callosum and eye anomalies. It is caused by de novo heterozygous mutation in the ZEB2 gene on chromosome 2q22."} +{"_id": "209", "text": "A pancreas disease that is characterized by the failure of the pancreas to develop prior to birth."} +{"_id": "212", "text": "An American histoplasmosis that results_in inflammation, located_in stomach lining in immunocompromised patients, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and results_in_formation_of gastric mass with ulceration, and results_in_formation_of hypertrophic gastric folds."} +{"_id": "215", "text": "A renal tubular transport disease characterized by excess levels of acid in the blood, due to a failure of the kidneys to appropriately acidify the urine."} +{"_id": "218", "text": "A brucellosis that involves an infection caused by Brucella melitensis in cattle, goats, sheep and humans. The disease has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom limb pain and has_symptom back pain."} +{"_id": "221", "text": "A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades."} +{"_id": "224", "text": "An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain."} +{"_id": "227", "text": "A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes."} +{"_id": "230", "text": "A head and neck cancer that has_material_basis_in epithelial cells and is located_in the upper aerodigestive tract, including the lip, oral cavity (mouth), nasal cavity, paranasal sinuses, pharynx, and larynx."} +{"_id": "233", "text": "A kidney sarcoma that starts in the bones and that is located_in the kidney."} +{"_id": "236", "text": "A Coronaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Torovirus, which is transmitted_by ingestion of food contaminated with feces."} +{"_id": "239", "text": "An agnosia that is a loss of the ability to recgonize a whole image or scene while retianing the ability to recognize objects or details in their visual field one at a time."} +{"_id": "242", "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice."} +{"_id": "245", "text": "A speech disorder that involves a complete inability to speak."} +{"_id": "248", "text": "A fish allergy triggered by Salmo salar."} +{"_id": "251", "text": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells."} +{"_id": "254", "text": "An esophageal carcinoma that derives_from epithelial cells of the salivary gland."} +{"_id": "257", "text": "A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination."} +{"_id": "260", "text": "An endodermal sinus tumor that occurs in children."} +{"_id": "263", "text": "A ssDNA virus infectious disease that results_in infection in humans, has_material_basis_in Anelloviridae viruses."} +{"_id": "266", "text": "A papillomavirus infectious disease and complicated_by acquired immunodeficiency syndrome that results_in infection, has_material_basis_in human papillomavirus, in patients with AIDS."} +{"_id": "269", "text": "A Measles virus infectious disease that results_in inflammation located_in cornea and located_in conjunctiva, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom mucopurulent discharge from the eye, has_symptom pain in the eye, and has_symptom redness."} +{"_id": "272", "text": "A sweat gland neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland."} +{"_id": "275", "text": "An amino acid metabolic disorder characterized by the formation 2,8-dihydroxyadenine stones and renal failure secondary to intratubular crystalline precipitation. It has an autosomal recessive inheritance pattern."} +{"_id": "278", "text": "A filariasis that involves parasitic infection of the abdomen in cattle, horses and sheep by nematodes of the genus Setaria."} +{"_id": "281", "text": "A human papillomavirus related carcinoma that results_in infection, has_material_basis_in human papillomavirus (types 16, or 18), which cause malignant tumors in squamous epithelium in genital and periungual areas."} +{"_id": "284", "text": "A severe combined immunodeficiency that is a X-linked SCID caused by mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells."} +{"_id": "287", "text": "A pneumonia that results_in inflammation located_in lung, has_material_basis_in Histoplasma capsulatum var capsulatum or Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom mediastinal lymphadenopathy, has_symptom cough and has_symptom chest pain."} +{"_id": "290", "text": "A sleeping sickness that involves infection caused by Trypanosoma brucei gambiense, which is carried by the tsetse fly. The symptoms include fever, rash, swelling of the face and hands, headaches, fatigue, aching muscles and joints, itching skin, swollen lymph nodes, progressive confusion, personality changes, daytime sleepiness with nighttime sleep disturbances, and other neurologic problems."} +{"_id": "293", "text": "A thrombophlebitis that is characterized by repeated occurances of thrombophlebitis in different locations."} +{"_id": "296", "text": "A spotted fever that has_material_basis_in Rickettsia helvetica, which is transmitted_by ticks (Ixodes sp). The infection has_symptom fever, has_symptom headache, has_symptom myalgia."} +{"_id": "299", "text": "An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance."} +{"_id": "302", "text": "A Cytomegalovirus infectious disease that results_in inflammation located_in stomach lining, has_material_basis_in Human herpesvirus 5, has_symptom dyspepsia, and has_symptom nausea and vomiting."} +{"_id": "305", "text": "A melanoma that is most commonly located_in sun-exposed skin and results_in_formation_ of spindle-like shaped cells that have a high recurrence rate even with treatment."} +{"_id": "308", "text": "An encephalitis that involves inflammation of the brain caused by viral infection."} +{"_id": "311", "text": "A Varicellovirus infectious disease that results_in inflammation located_in liver, has_material_basis_in Human herpesvirus 3, has_symptom skin rash, has_symptom oral lesions, has_symptom severe abdominal and back pain, has_symptom fever, has_symptom chills, has_symptom malaise, and has_symptom fatigue."} +{"_id": "314", "text": "A sleeping sickness that involves infection caused by Trypanosoma brucei rhodesiense, which is carried by the tsetse fly. The symptoms include fever, severe headache, irritability, extreme fatigue, swollen lymph nodes, aching muscles and joints, skin rash, progressive confusion, personality changes, and other neurologic problems."} +{"_id": "317", "text": "A hypersensitivity reaction type IV disease that results from the presence of excessive amounts of a single monoclonal gammaglobulin in the blood."} +{"_id": "320", "text": "An impetigo that is characterized as a form of severe pustular psoriasis occurring in pregnancy."} +{"_id": "323", "text": "A viral infectious disease that results_in infection in deer, has_material_basis_in Epizootic hemorrhagic disease virus, which is transmitted_by Culicoides biting midges. The infection has_symptom hemorrhages in many tissues including the skin, heart, and gastrointestinal tract, and has_symptom ulcers of the tongue, dental pad, palate, rumen, and omasum."} +{"_id": "326", "text": "A specific developmental disorder that is characterized by repeated, rhythmic, purposeless movements or activities such as head banging, nail biting, or body rocking."} +{"_id": "329", "text": "A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans."} +{"_id": "332", "text": "A male reproductive organ cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is_located_in the Littre glands."} +{"_id": "335", "text": "A Varicellovirus infectious disease that results_in infection located_in eye, has_material_basis_in Human herpesvirus 3, which reactivates from the trigeminal ganglion after the primary infection."} +{"_id": "338", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected."} +{"_id": "341", "text": "A bile duct disease that is an inflammation of the bile duct."} +{"_id": "344", "text": "A personality disorder that involves an excessive preoccupation with issues of personal adequacy, power, prestige and vanity."} +{"_id": "347", "text": "An impulse control disorder that involves the uncontrollable impulse to repeatedly set fires with no obvious motive."} +{"_id": "350", "text": "An African histoplasmosis that results_in inflammation located_in pericardium, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom pleural effusions, has_symptom chest pain and has_symptom cough."} +{"_id": "353", "text": "An intestinal disease located_in the cecum."} +{"_id": "356", "text": "A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix."} +{"_id": "359", "text": "A Pasteurella infectious disease that involves infection by the bacterium Mannheimia haemolytica and less frequently by Pasteurella multocida and Histophilus somni. After stress or viral infection, the replication rate of M. haemolytica in the upper respiratory tract increases rapidly, followed by inhalation and colonization of the lungs due to suppression of the host's defense mechanism. The bacterium produces exotoxin called leukotxin which interacts with the host's defense mechanism resulting in tissue damage with charactersistic necrosis, thrombosis, and exudation and the development of pneumonia."} +{"_id": "362", "text": "A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head."} +{"_id": "365", "text": "A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs."} +{"_id": "368", "text": "A pulmonary tuberculosis which involves inflammation of bronchi resulting in irregular circumferential bronchial wall thickening that leads to narrowed or even obstructed airways."} +{"_id": "371", "text": "An autosomal dominant disease that is characterized by short stature, sparse hair, a bulbous nasal tip and cone-shaped epiphyses (the growing ends of bones), as well as severe generalized shortening of all finger and toe bones (brachydactyly)."} +{"_id": "374", "text": "A histidine metabolism disease that involves a deficiency of the enzyme histidase."} +{"_id": "377", "text": "A Parkinson's disease caused by mutation in the parkin gene, PARK2, on chromosome 6q25.2-q27."} +{"_id": "380", "text": "A human papilloma virus related cervical squamous cell carcinoma that results_in infection located_in cervix, has_material_basis_in human papillomavirus (types 16 or 18), which cause papillae in squamous epithelium of cervix."} +{"_id": "383", "text": "A systemic mycosis that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices."} +{"_id": "386", "text": "An organic acidemia that disrupts or prevents normal metabolism of the branched-chain amino acid leucine."} +{"_id": "389", "text": "A cardiovascular system disease that involves the heart."} +{"_id": "392", "text": "A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell)."} +{"_id": "395", "text": "An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall."} +{"_id": "398", "text": "An immune system disease that is caused by abnormal immune responses."} +{"_id": "401", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding."} +{"_id": "404", "text": "A thyroid cancer that has_material_basis_in epithelial cells."} +{"_id": "407", "text": "A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans."} +{"_id": "410", "text": "A dystonia that is localized to a specific part of the body."} +{"_id": "413", "text": "A bartonellosis that has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella quintana. The disease is characterized by the proliferation of blood vessels, resulting in them forming tumour-like masses in the skin and other organs."} +{"_id": "416", "text": "A disease of cellular proliferation that results in an abnormal mass of tissue."} +{"_id": "419", "text": "A germ cell cancer that has_material_basis_in cells that line the yolk sac of the embryo."} +{"_id": "422", "text": "A combined T cell and B cell immunodeficiency that is caused by a mutatino in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay."} +{"_id": "425", "text": "A viral infectious disease that results_in infection, has_material_basis_in RNA viruses, which have RNA as their genetic material."} +{"_id": "428", "text": "A Vibrio infectious disease that involves inflammation of the stomach and intestines caused by noncholera Vibrio species like Vibrio parahaemolyticus, Vibrio fluvialis and Vibrio vulnificus. Some species produce enterotoxins, which impair intestinal absorption, resulting in watery diarrhea. The symptoms include abdominal cramps, fever, vomiting, nausea and diarrhea."} +{"_id": "431", "text": "An embryonal carcinoma that is located_in the ovary."} +{"_id": "434", "text": "A breast carcinoma that derives_from breast lobules (milk glands)."} +{"_id": "437", "text": "An anal canal cancer that derives_from epithelial cells of glandular origin."} +{"_id": "440", "text": "An eye disease that is located_in the retina."} +{"_id": "443", "text": "A tinea capitis that results_in fungal infection located_in cuticle of hair, has_material_basis_in Microsporum canis, has_material_basis_in Microsporum gypseum, has_material_basis_in Trichophyton equinum, and has_material_basis_in Trichophyton verrucosum, which produce arthroconidia on the exterior of the hair shaft."} +{"_id": "446", "text": "A dsDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Polyomaviridae viruses."} +{"_id": "449", "text": "An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone."} +{"_id": "452", "text": "An Enterovirus infectious disease that results_in infection, has_material_basis_in group A coxsackievirus or has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom paralysis, has_symptom myositis, and has_symptom degeneration of neuronal tissue."} +{"_id": "455", "text": "A fibrosarcoma of soft tissue and small intestinal sarcoma that is located_in the small bowel."} +{"_id": "458", "text": "A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites."} +{"_id": "461", "text": "A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver."} +{"_id": "464", "text": "A lysosomal storage disease that has_material_basis_in deficiency of the beta-A-manosidase enzyme resulting in the disruption of N-linked glycoprotein oligosaccharide catabolism."} +{"_id": "467", "text": "An acrofacial dysostosis characterized by underdeveloped cheek bones, very small lower jaw, cleft palate, defects in the middle ear, absent eyelashes, and a notch in the lower eyelids called a coloboma, in children."} +{"_id": "470", "text": "A syndrome characterized by a combination of obesity, retarded development of the sex glands, and changes in secondary sex characteristics that results from impaired function or disease of the pituitary gland and hypothalamus."} +{"_id": "473", "text": "An opportunistic mycosis that results_in systemic fungal infection in immunocompromised people, has_material_basis_in Microsporidia phylum members."} +{"_id": "476", "text": "A vein disease that is characterized by inflammation of a vein."} +{"_id": "479", "text": "A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae."} +{"_id": "482", "text": "A viral infectious disease that results_in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted_by Phlebotomus papatasi sandfly. The infection has_symptom fever, has_symptom severe frontal headaches, has_symptom muscle ache, has_symptom joint aches, has_symptom flushing of the face, and has_symptom tachycardia."} +{"_id": "485", "text": "An acromesomelic dysplasia that has_material_basis_in mutation in CDMP-1 which results_in micromelia, absence of middle and proximal phalanges and some metacarpal and metatarsal bones."} +{"_id": "488", "text": "A gastrointestinal tuberculosis that results_in inflammation located_in peritoneum, which results in formation of tubercles. The infection has_symptom abdominal discomfort, has_symptom pain, has_symptom distention from gas or fluid, has_symptom digestive disturbances and has_symptom emaciation."} +{"_id": "491", "text": "A gonadal disease that is characterized by diminished functional activity of the gonads."} +{"_id": "494", "text": "A muscle tissue disease that is characterised by slow muscle relaxation associated with hyperexcitation of the muscle fibres."} +{"_id": "497", "text": "An orofaciodigital syndrome characterized_by polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of the OFD1 gene."} +{"_id": "500", "text": "An ampulla of Vater carcinoma that derives_from epithelial squamous cells."} +{"_id": "503", "text": "A rubella that results_in infection has_material_basis_in Rubella virus, which is transmitted_by congenital method to the developing fetus of a pregnant woman who has contracted rubella during her first trimester."} +{"_id": "506", "text": "A vulvovaginal candidiasis that involves fungal infection of the vaginal mucous membranes by Candida albicans in AIDS patients."} +{"_id": "509", "text": "A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck."} +{"_id": "512", "text": "A respiratory system cancer that is located_in the larynx."} +{"_id": "515", "text": "A hepatitis that involves viral infection causing inflammation of the liver."} +{"_id": "518", "text": "An extrinsic allergic alveolitis involving inflammation of the alveoli within the lung caused by hypersensitivity to the inhalation of organic dust particles derived from either the mushrooms, their spores or the compost in which the mushrooms are grown. It is usually caused by the spores of thermophilic actinomycetes."} +{"_id": "521", "text": "A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs."} +{"_id": "524", "text": "A cranial nerve disease that is located_in the optic nerve."} +{"_id": "527", "text": "A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior."} +{"_id": "530", "text": "A monogenic disease that has_material_basis_in muations in genes on the X chromosome."} +{"_id": "533", "text": "A pancreas cancer that derives_from epithelial cells located_in the pancreas."} +{"_id": "536", "text": "A spotted fever that has_material_basis_in Rickettsia akari, which is transmitted_by house mouse mite (Liponyssoides sanguineus) found on mice and other rodents. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, and has_symptom papulovesicular rash."} +{"_id": "539", "text": "A neuroendocrine tumor that results_in an overproduction of gastric acid."} +{"_id": "542", "text": "A craniosynostosis that involves premature fusion of certain skull bones. This early fusion prevents the skull from growing normally and affects the shape of the head and face. The disease is associated with mutations in the FGFR2 gene."} +{"_id": "545", "text": "A congenital disorder of glycosylation involve disrupted synthesis of the lipid-linked oligosaccharide precursor."} +{"_id": "548", "text": "A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium."} +{"_id": "551", "text": "An organ system cancer that is located_in the skin, hair and nails."} +{"_id": "554", "text": "A gastrointestinal system disease that is located_in the intestine."} +{"_id": "557", "text": "An actinomycosis that involves invasion and infiltration located_in large intestine, located_in greater omentum, or located_in abdominal wall, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus or has_material_basis_in Actinomyces meyeri, which produce a characteristic granulomatous inflammatory response, with pus production and has_symptom abscess formation."} +{"_id": "560", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of dogs, cats and foxes with Toxascaris leonina causing damage to the lining of the intestine. The symptoms include diarrhea, vomiting and loss of appetite."} +{"_id": "563", "text": "An eye disease characterized by missing pieces of tissue in structures that form the eye, such as the iris, retina, choroid or optic disc."} +{"_id": "566", "text": "A trichostrongyloidiasis that involves parasitic infection of the bronchial tree of horses, sheep, goats, deer, and cattle by nematodes of the genus Dictyocaulus."} +{"_id": "569", "text": "A dermatomycosis that results_in fungal infection located_in nail, has_material_basis_in Neoscytalidium dimidiatum and has_symptom rough nail, and has_symptom crumbly nail which can separate from the nail bed."} +{"_id": "572", "text": "A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located_in the upper dermis."} +{"_id": "575", "text": "A malignant glioma that is has_material_basis_in astocyte cells, a type of star-shaped glial cell, located_in the cerebrum."} +{"_id": "578", "text": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney."} +{"_id": "581", "text": "A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency."} +{"_id": "584", "text": "A large intestine cancer that has_material_basis_in epithelial cells of glandular origin."} +{"_id": "587", "text": "A syndrome characterized byvariable expression of microcephaly, ocular disorders including chorioretinopathy, congenital lymphedema of the lower limbs, and mild to moderate intellectual disability."} +{"_id": "590", "text": "A spinal cord glioma that has_material_basis_in cells linking the spinal cord central canal."} +{"_id": "593", "text": "A urinary system disease that is located_in the urethra."} +{"_id": "596", "text": "A skin disease characterized by a defect in the normal process of keratinization of the mucosa."} +{"_id": "599", "text": "A Charcot-Marie-Tooth disease that is characterized by early-onset optic atrophy resulting in progressive visual loss and peripheral axonal sensorimotor neuropathy with highly variable age at onset and severity."} +{"_id": "602", "text": "An autoimmune disease of the central nervous system."} +{"_id": "605", "text": "A cell type benign neoplasm that is a benign tumor of smooth muscle cells."} +{"_id": "608", "text": "A human papillomavirus related carcinoma that results_in infection, has_material_basis_in human papillomaviruses (types 16, 18, 31, 39 or 45), which cause lesions that progress to cancers."} +{"_id": "611", "text": "A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms."} +{"_id": "614", "text": "An anal carcinoma that arises near the squamocolumnar junction."} +{"_id": "617", "text": "Esotropia is a strabismus in which the eye turns inward toward the nose."} +{"_id": "620", "text": "A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. It has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma."} +{"_id": "623", "text": "A lymphatic system cancer that affects white blood cells and involves tumor deposits in the spleen."} +{"_id": "626", "text": "A female reproductive system disease characterized by the implantation of the embryo outside the uterine cavity."} +{"_id": "629", "text": "A pneumococcal infectious disease that involves infection by the bacterium Streptococcus pneumoniae, also known as pneumococcus. In adults, pneumococcal pneumonia is often characterized by sudden onset of illness with symptoms including shaking chills, fever, shortness of breath or rapid breathing, pain in the chest that is worsened by breathing deeply, and a productive cough. In infants and young children, signs and symptoms may not be specific, and may include fever, cough, rapid breathing or grunting."} +{"_id": "632", "text": "A syndrome that is a chronic unilateral (or rarely bilateral) iridocyclitis appearing with the triad of heterochromia, predisposition to cataracts and glaucoma, and keratitic percipitates on the posterior corneal surface."} +{"_id": "635", "text": "An ectothrix infectious disease that results_in geophilic fungal infection located_in scalp and located_in hair in humans and animals, has_material_basis_in Microsporum fulvum."} +{"_id": "638", "text": "A RNA virus infectious disease that results_in infection, has_material_basis_in ssRNA negative-strand viruses, which have negative-sense single-stranded RNA genomes."} +{"_id": "641", "text": "A malaria characaterized as a relatively mild form caused by a parasite Plasmodium ovale, which is characterized by tertian chills and febrile paroxysms, and that ends spontaneously."} +{"_id": "644", "text": "A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood."} +{"_id": "647", "text": "A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy."} +{"_id": "650", "text": "A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand."} +{"_id": "653", "text": "A malignant vascular tumor that results_in rapidly proliferating, extensively infiltrating anaplastic cells derived_from blood vessels and derived_from the lining of irregular blood-filled spaces."} +{"_id": "656", "text": "A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis."} +{"_id": "659", "text": "A lung carcinoma that is located_in large undifferentiated cells."} +{"_id": "662", "text": "A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung."} +{"_id": "665", "text": "An agnosia that is a deficiency in understanding, processing, or describing emotions."} +{"_id": "668", "text": "An osteochondrodysplasia that results_in thinning and the tendency to fracture located_in bone."} +{"_id": "671", "text": "An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway."} +{"_id": "674", "text": "An artery disease characterized by chronic elevated blood pressure in the arteries."} +{"_id": "677", "text": "A type of ALS with juvenile onset caused_by mutation located_in senataxin gene (SETX) located_in chromosome 9."} +{"_id": "680", "text": "An autosomal recessive disease that involves abnormal development of the pancreas, nose and scalp, with mental retardation, hearing loss and growth failure. It is inherited in an autosomal recessive manner."} +{"_id": "683", "text": "A smallpox that results_in milder infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions."} +{"_id": "686", "text": "A nonsyndromic deafness characterized by an autosomal dominant inheritance mode."} +{"_id": "689", "text": "A disease that is characterized by abnormally rapid cell division."} +{"_id": "692", "text": "A motor neuron disease characterized by painless but progressive weakness and stiffness of the muscles of the legs."} +{"_id": "695", "text": "A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis."} +{"_id": "698", "text": "An immune system disease that is located_in the lymphatic system."} +{"_id": "701", "text": "A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism."} +{"_id": "704", "text": "A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis."} +{"_id": "707", "text": "A vitamin metabolic disorder that has_material_basis_in mutations in the folate receptor 1 (FOLR1) gene coding for folate receptor alpha (FRalpha), is located_in the brain and is characterized by progressive movement disturbance, psychomotor decline, and epilepsy."} +{"_id": "710", "text": "A vascular disease that is characterized by a restriction in blood supply to tissues."} +{"_id": "713", "text": "A tertiary neurosyphilis that results_in mild meningitis."} +{"_id": "716", "text": "A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs."} +{"_id": "719", "text": "A viral infectious disease that results_in infection located_in joint, has_material_basis_in Ross River virus, which is transmitted_by Culex, and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash."} +{"_id": "722", "text": "An organic acidemia that involves an accumulation of methylmalonic acid in the blood."} +{"_id": "725", "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system."} +{"_id": "728", "text": "A parasitic protozoa infectious disease that occurs in the intestinal tract of animals and humans caused by Coccidia protozoa. Immunocompromised persons are at greater risk of developing the infection."} +{"_id": "731", "text": "A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy."} +{"_id": "734", "text": "An extragonadal germ cell cancer that are located_in the pineal gland in the brain, located_in the mediastinum or located_in the abdomen."} +{"_id": "737", "text": "A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_physical_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region."} +{"_id": "740", "text": "A Q fever that is a zoonotic infectious disease caused by Coxiella burnetii, a bacterium which affects both humans and animals. The symptoms include fever, headache, cough, pleuritic chest pain, myalgia and arthralgia. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, or excreta of infected herd animals, ingestion of contaminated milk, tick bites and human to human transmission."} +{"_id": "743", "text": "A rhabdomyosarcoma and sarcoma of the anus that is located_in the anus."} +{"_id": "746", "text": "A personality disorder that is characterized by a pervasive pattern of preoccupation with orderliness, perfectionism, and mental and interpersonal control at the expense of flexibility, openness, and efficiency."} +{"_id": "749", "text": "An achondrogenesis that has_material_basis_in mutations in the COL2A1 gene which results_in underdeveloped lungs, hydrops fetalis, a prominent forehead and abnormal ossification of the located_in vertebral column or located_in pelvis."} +{"_id": "752", "text": "A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange."} +{"_id": "755", "text": "A corneal disease characterized by a bilaterally enlarged corneal diameter without an increase in intraocular pressure; caused_by mutation in the CHRDL1 gene."} +{"_id": "758", "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in anus, has_material_basis_in human papillomavirus (types 16 or 18), which cause malignant tumors in squamous epithelium of anus."} +{"_id": "761", "text": "A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles."} +{"_id": "764", "text": "A liposarcoma and mediastinum sarcoma that is located_in the mediastinum."} +{"_id": "767", "text": "A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock."} +{"_id": "770", "text": "A Measles virus infectious disease that results_in inflammation located_in liver, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection causes hepatic dysfunction and has_symptom jaundice."} +{"_id": "773", "text": "A lactic acidosis that has_material_basis_in high levels of acid."} +{"_id": "776", "text": "A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance."} +{"_id": "779", "text": "An amino acid metabolic disorder that involves a deficiency of one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream."} +{"_id": "782", "text": "A nervous system cancer that is located_in the central nervous system."} +{"_id": "785", "text": "A delusional disorder in which a person holds a delusion that a friend, spouse, parent, or other close family member has been replaced by an identical-looking impostor."} +{"_id": "788", "text": "A urinary system disease that is located_in the bladder."} +{"_id": "791", "text": "A coccidioidomycosis that results_in inflammation located_in meninges, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom headache, has_symptom alterations in sensorium, and has_symptom obstructing hydrocephalus."} +{"_id": "794", "text": "A retinoblastoma that is located_in the eye and has not spread to other parts of the body."} +{"_id": "797", "text": "A somatoform disorder that involves persistently complaints of varied physical symptoms that have no identifiable physical origin."} +{"_id": "800", "text": "A gastrointestinal system disease that is located_in the liver and/or biliary tract."} +{"_id": "803", "text": "A tongue cancer that is located_in the squamous cells of the tongue."} +{"_id": "806", "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia."} +{"_id": "809", "text": "A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities."} +{"_id": "812", "text": "A tularemia that results_in swelling of regional lymph glands."} +{"_id": "815", "text": "An extrapulmonary tuberculosis that results in formation of lesions located_in bone."} +{"_id": "818", "text": "A familial hyperlipidemia characterized by very high levels of low-density lipoprotein (LDL) and early cardiovascular disease."} +{"_id": "821", "text": "A lung carcinoma that has_material_basis in a combination of squamous cells, mucus secreting cells and intermediate cells."} +{"_id": "824", "text": "A central nervous system disease characterized by acute neuritis located_in eye and demyelination located_in optic nerve and located_in spinal cord."} +{"_id": "827", "text": "An endothrix infectious disease that results_in anthropophilic fungal infection located_in scalp and located_in hair, has_material_basis_in Trichophyton soudanense."} +{"_id": "830", "text": "A pleural empyema which involves presence of pus in the pleural cavity and calcified visceral pleura. It results from a large number of mycobacteria spilling into the pleural space, usually from rupture of a cavity or an adjacent paranchymal focus via a bronchopleural fistula."} +{"_id": "833", "text": "An intrinsic cardiomyopathy characterized by distinctive (spongy) morphological appearance of the LV myocardium."} +{"_id": "836", "text": "A malignant mediastinal neurogenic neoplasm that has_material_basis_in immature nerve cells."} +{"_id": "839", "text": "A lysosomal storage disease characterized by increased sialic acid in the urine."} +{"_id": "842", "text": "A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person."} +{"_id": "845", "text": "A retinoblastoma that develops in both eyes."} +{"_id": "848", "text": "A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans."} +{"_id": "851", "text": "A HIV encephalopathy that results_in infection in adults located_in brain, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom cognitive impairment, has_symptom motor dysfunction, has_symptom behavioral change, and has_symptom speech problems."} +{"_id": "854", "text": "A viral infectious disease that results_in infection located_in brain in sheep and goats, has_material_basis_in Visna/Maedi virus , which is transmitted_by droplet spread of oronasal secretion, and transmitted_by ingestion of contaminated water, milk or colostrum. The infection has_symptom hindlimb weakness, has_symptom head tilt, has_symptom ataxia, has_symptom incoordination, has_symptom muscle tremors, has_symptom paresis, and has_symptom paraplegia."} +{"_id": "857", "text": "A leukemia that is characterized by the presence of abnormal white blood cells located_in peripheral blood, but in which the total number of white blood cells is normal."} +{"_id": "860", "text": "A plague that results_in infection located_in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has_symptom enlarged, tender lymph nodes, has_symptom fever, has_symptom chills and has_symptom prostration."} +{"_id": "863", "text": "A primary systemic mycosis that results_in systemic fungal infection through hematogenous spread, has_material_basis_in Paracoccidioides brasiliensis."} +{"_id": "866", "text": "A disease of anatomical entity that is located_in the thoracic cavity."} +{"_id": "869", "text": "A genetic disease that require multiple abnormal alleles to manifest are complex. These diseases are termed multifactorial or polygenic. Expressivity or penetrance of the disease is complex and is associated with multiple genes in combination with lifestyle and environmental factors. Multifactoral genetic diseases include heart disease and diabetes, although a subset of diabetes may be classified as a monogenic disease (due to the presence of a single abnormal allele)."} +{"_id": "872", "text": "A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells."} +{"_id": "875", "text": "A myeloma and spenic disease that is located_in the bone marrow that results_in the marrow being replaced by fibrous (scar) tissue and has_symptom abdominal fullness related to an enlarged spleen, has_symptom bone pain, has_symptom bruising, has_symptom easy bleeding, has_symptom fatigue, has_symptom increased susceptibility to infection, has_symptom pallor, has_symtom shortness of breath while doing physical work."} +{"_id": "878", "text": "A focal dystonia that is characterized by simultaneous contraction of the agonist and antagonist muscles that control the position of the head contracting during dystonic movement which causes the neck to involuntarily turn to the left, right, upwards, and/or downwards."} +{"_id": "881", "text": "An autosomal dominant disease that is characterized by imperforate anus, dysplastic ears often associated with sensorineural and/or conductive hearing impairment, and thumb malformations."} +{"_id": "884", "text": "An osteochondrodysplasia that has_material_basis_in mutations in the COMP gene which results_in short limb dwarfism."} +{"_id": "887", "text": "An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism."} +{"_id": "890", "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme alpha-L-iduronidase."} +{"_id": "893", "text": "A primary systemic mycosis that results_in inflammation located_in lungs, has_material_basis_in Paracoccidioides brasiliensis and has_symptom cough, has_symptom fever, has_symptom night sweats, has_symptom malaise, and has_symptom weight loss."} +{"_id": "896", "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue."} +{"_id": "899", "text": "An opportunistic mycosis that involves localized or hematogenously disseminated fungal infection by Fusarium solani or Fusarium oxysporum. Skin lesions are seen in neutropenic patients, and indolent cellulitis or soft-tissue necrosis occur in immunocompromised patients at the site of trauma."} +{"_id": "902", "text": "An adenovirus infectious disease described as the infection of the lungs by adenoviruses (1,2, 3 and 7) especially in infants and children. In mild form of infection, findings of interstitial inflammatory cell infiltration may predominate, and nuclear inclusion bodies, most prominent in alveolar lining cells, may be identified in infected cells."} +{"_id": "905", "text": "A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy."} +{"_id": "908", "text": "An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities."} +{"_id": "911", "text": "A peroxisomal disease that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes."} +{"_id": "914", "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash."} +{"_id": "917", "text": "A primary bacterial infectious disease that results_in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli."} +{"_id": "920", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection by flukes of the genus Paragonimus. In the acute phase, the symptoms are diarrhea, abdominal pain, fever, cough, urticaria, hepatosplenomegaly, pulmonary abnormalities, and eosinophilia. Pulmonary manifestations include cough, expectoration of discolored sputum, hemoptysis, and chest radiographic abnormalities. Various organs like brain, spleen and liver can be infected."} +{"_id": "923", "text": "A reproductive system disease that affects male reproductive organs."} +{"_id": "926", "text": "A primary bacterial infectious disease that results_in infection located_in skin, located_in joint or located_in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has_symptom skin lesions."} +{"_id": "929", "text": "A ssRNA-RT virus infectious disease that results_in infection in animals and humans, has_material_basis_in Retroviridae viruses."} +{"_id": "932", "text": "An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough."} +{"_id": "935", "text": "A hypertension with no known cause. It is the most common type of hypertension."} +{"_id": "938", "text": "An X-linked disease that is characterized by profound congenital sensorineural hearing impairment, early-onset hypotonia, delayed motor development, mild to moderate intellectual disability, ataxia, and increased risk of infection and has_material_basis_in mutations of the PRPS1 gene."} +{"_id": "941", "text": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma."} +{"_id": "944", "text": "A lipid metabolism disorder characterized by elevated triglyceride levels as a result of excess hepatic production of VLDL or heterozygous LPL deficiency."} +{"_id": "947", "text": "An autosomal recessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy."} +{"_id": "950", "text": "A Kaposi's sarcoma and AIDS-related malignancy that results_in the occurence of Kaposi's sarcoma in people that have progressed to AIDS."} +{"_id": "953", "text": "A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree."} +{"_id": "956", "text": "A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy."} +{"_id": "959", "text": "An eye disease characterized by the drooping or falling of the upper or lower eyelid."} +{"_id": "962", "text": "An agnosia that is a loss of the ability to integrate these elements together into comprehensible perceptual wholes while recognizing elements of the whole."} +{"_id": "965", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding."} +{"_id": "968", "text": "A pancreatic cancer that is located_in the pancreas and that arises from transformed cells of mesenchymal origin."} +{"_id": "971", "text": "A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches."} +{"_id": "974", "text": "A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough."} +{"_id": "977", "text": "A carcinoma in situ that is characterized by the spread of cancer in the digestive organ and the lack of invasion of surrounding tissues."} +{"_id": "980", "text": "A breast disease characterized by a collection of pus in the breast."} +{"_id": "983", "text": "An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures."} +{"_id": "986", "text": "An inflammatory bowel disease that involves inflammation located_in colon."} +{"_id": "989", "text": "A sarcoma that affects children and is located_in the soft tissues of the body."} +{"_id": "992", "text": "A prostate carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "995", "text": "An endocrine gland located_in the pineal gland located in the brain."} +{"_id": "998", "text": "A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells."} +{"_id": "1001", "text": "A neuromuscular junction disease that results from an abnormality of acetylcholine (ACh) release at the neuromuscular junction. It results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal."} +{"_id": "1004", "text": "A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food."} +{"_id": "1007", "text": "A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze."} +{"_id": "1010", "text": "A parasitic stramenopiles infectious disease that involves infection of the intestine with a pathogenic heterokont Blastocystis hominis. The symptoms include watery diarrhea, abdominal pain, perianal pruritus, and excessive flatulence."} +{"_id": "1013", "text": "A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight."} +{"_id": "1016", "text": "A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs."} +{"_id": "1019", "text": "A nonparalytic poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 3, which is transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms."} +{"_id": "1022", "text": "A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers."} +{"_id": "1025", "text": "A bone structure disease that results_in change or damage of structure located_in bone."} +{"_id": "1028", "text": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions."} +{"_id": "1031", "text": "A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb."} +{"_id": "1034", "text": "A myopathy characterized by muscle inflammation."} +{"_id": "1037", "text": "A type of ALS caused_by mutation located_in CHMP2B gene located_in chromosome 3."} +{"_id": "1040", "text": "A hematologic cancer that has_material_basis_in lymphoma located_in central nervous system."} +{"_id": "1043", "text": "A bone development disease that results_in defective development of cartilage or bone."} +{"_id": "1046", "text": "A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency."} +{"_id": "1049", "text": "A bone remodeling disease that results in an abnormal decrease of bone density or mass."} +{"_id": "1052", "text": "A mycoplasmal pneumonia that is a contagious infection of pigs caused my Mycoplasma hyopneumoniae resulting in lung lesions and chronic cough."} +{"_id": "1055", "text": "An organ system benign neoplasm located_in gastrointestinal tract organs."} +{"_id": "1058", "text": "A type of ALS caused_by mutation located_in FIG4 gene located_in chromosome 6."} +{"_id": "1061", "text": "A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body."} +{"_id": "1064", "text": "An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derived_from multiple cell types including astrocytes and oligondroctyes."} +{"_id": "1067", "text": "A specific developmental disorder that involves specific developmental disorders of speech and language."} +{"_id": "1070", "text": "A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts."} +{"_id": "1073", "text": "An ovary epithelial cancer that has_material_basis_in the endometrium and is located_in the ovary."} +{"_id": "1076", "text": "A hypersensitivity reaction type I disease triggered by a metal."} +{"_id": "1079", "text": "An intestinal benign neoplasm that is located_in the cecum."} +{"_id": "1082", "text": "A bartonellosis that results_in infection located_in endothelial cells or located_in red blood cells, has_material_basis_in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed."} +{"_id": "1085", "text": "A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body."} +{"_id": "1088", "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Flaviviridae viruses, which are transmitted_by arthropod vectors."} +{"_id": "1091", "text": "An autosomal recessive disease characterized by photosensitivity and liver spots (solar lentigines)."} +{"_id": "1094", "text": "An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life."} +{"_id": "1097", "text": "An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system."} +{"_id": "1100", "text": "A pneumococcal infectious disease that involves inflammation of the peritoneum caused by streptococcal infection. The symptoms include diarrhea, fever, fasciitis and influenza-like syndrome."} +{"_id": "1103", "text": "A reading disorder resulting from a developmental reading disability involving the inability to process graphic symbols resulting in impairment of reading ability."} +{"_id": "1106", "text": "A labyrinthitis which involves viral infection of the inner ear through the upper airway or the blood stream. The symptoms may include hearing loss and ringing in the ears. If the virus reaches the vestibular system, dizziness, severe vertigo with nausea and vomiting, and imbalance can occur."} +{"_id": "1109", "text": "A type of ALS caused_by mutation located_in PFN1 gene located_in chromosome 17."} +{"_id": "1112", "text": "A physical disorder that has_material_basis_in abnormal segmentation of the vertebra during fetal development which results_in fusion located_in cervical vertebra."} +{"_id": "1115", "text": "An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue."} +{"_id": "1118", "text": "A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly."} +{"_id": "1121", "text": "An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes."} +{"_id": "1124", "text": "A hypersensitivity reaction type I disease triggered by a drug."} +{"_id": "1127", "text": "A germ cell cancer that is associated with an embryo."} +{"_id": "1130", "text": "A monogenic disease that results from a reduced functionality of DNA repair."} +{"_id": "1133", "text": "A bone cancer and malignant neoplasm of chest wall that is located_in the chest wall."} +{"_id": "1136", "text": "A Kaposi's sarcoma that is located_in black Africans."} +{"_id": "1139", "text": "A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous."} +{"_id": "1142", "text": "An organ system benign neoplam that is located_in the thoracic cavity."} +{"_id": "1145", "text": "A cholestasis characterized by blockage of the ducts that carry bile from the liver to the gallbladder."} +{"_id": "1148", "text": "A histiocytic and dendritic cell cancer that is mainly located_in lymph nodes."} +{"_id": "1151", "text": "A mitochondrial metabolism disease that has material basis in mutation in the ATP5A1 gene on chromosome 18q."} +{"_id": "1154", "text": "A pyoderma that is a milder form of diphtheria restricted to the skin producing shallow skin ulcers is caused by direct physical contact of indivduals infected with Corynebacterium diphtheriae as the bacteria releases the diphtheria toxin."} +{"_id": "1157", "text": "An African histoplasmosis that results_in inflammation located_in lung, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom mediastinal lymphadenopathy, has_symptom cough and has_symptom chest pain."} +{"_id": "1160", "text": "A brucellosis that involves an infection caused by Brucella suis in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue."} +{"_id": "1163", "text": "A retinoblastoma that effects only one eye."} +{"_id": "1166", "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Cytomegalovirus, which is transmitted_by contact with the infected person's bodily fluids or transmitted_by sexual contact, or transmitted_by blood transfusions."} +{"_id": "1169", "text": "An inherited blood coagulation disease that has_material_basis_in Factor IX deficiency, which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait."} +{"_id": "1172", "text": "A monogenic disease that is caused by a mutation in a single gene on one of the non-sex chromosomes."} +{"_id": "1175", "text": "A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation."} +{"_id": "1178", "text": "A frontal sinusitis which lasts for less than 4 weeks."} +{"_id": "1181", "text": "A crustacean allergy triggered by Farfantepenaeus aztecus."} +{"_id": "1184", "text": "A Simplexvirus infectious disease that results_in inflammation located_in external ear, has_material_basis_in Human herpesvirus 1 or has-agent Human herpesvirus 2 and has_symptom vesicles in the ear canal."} +{"_id": "1187", "text": "An endothrix infectious disease that results_in anthropophilic fungal infection located_in scalp and located_in hair, has_material_basis_in Trichophyton yaoundei, results_in_formation_of lesions."} +{"_id": "1190", "text": "A carcinosarcoma that has_material_basis_in gland and muscle components."} +{"_id": "1193", "text": "A bacterial pneumonia caused by the genus Mycoplasma."} +{"_id": "1196", "text": "A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has_symptom gummatous ulcers, has_symptom periosteal lesions, has_symptom paresis, has_symptom tabes, has_symptom optic atrophy, has_symptom interstitial keratitis, has_symptom sensorineural deafness, and has_symptom dental deformities."} +{"_id": "1199", "text": "A neuropathy that is located_in one of the twelve cranial nerves."} +{"_id": "1202", "text": "A genital herpes that results_in infection located_in vulva and located_in vagina, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2 and has_symptom fever, has_symptom lymphadenopathy, and has_symptom lesions."} +{"_id": "1205", "text": "A leiomyosarcoma and sarcoma of bile duct that is located_in the bile duct or located_in the outside of the liver."} +{"_id": "1208", "text": "A bilirubin metabolic disorder that involves a build up of bilirubin as bilirubin is not being broken down as a result of a lack or deficiency of the enzyme uridine diphosphate glycosyltransferase (UGT)."} +{"_id": "1211", "text": "An arthritis that involves infection by a pathogen located_in joint."} +{"_id": "1214", "text": "A lymphatic system cancer that is located_in the lymph node."} +{"_id": "1217", "text": "A glomerulonephritis characterized by build up of IgA antibody in the glomerulus."} +{"_id": "1220", "text": "A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc."} +{"_id": "1223", "text": "A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis."} +{"_id": "1226", "text": "A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules."} +{"_id": "1229", "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria."} +{"_id": "1232", "text": "A kyphosis that has_material_basis_in slouching which results_in stretching of spinal ligament and abnormal formation located_in vertebra."} +{"_id": "1235", "text": "A central nervous system sarcoma that is located_in the inner lining of blood vessels."} +{"_id": "1238", "text": "A combined T cell and B cell immunodeficiency that is an autosomal recessive immunodeficiency associated with mutations in the recombination activating genes (RAG1 and RAG2), affecting circulating levels of both B-cells and T-cells."} +{"_id": "1241", "text": "A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash."} +{"_id": "1244", "text": "A peritonitis which involves inflammation of peritoneal cavity by Corynebacterium diphtheriae."} +{"_id": "1247", "text": "A pelvic varix disease characterized by swollen, inflamed veins around the anus or lower rectum."} +{"_id": "1250", "text": "A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure."} +{"_id": "1253", "text": "A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death."} +{"_id": "1256", "text": "An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body."} +{"_id": "1259", "text": "An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain."} +{"_id": "1262", "text": "A supratentorial cancer that is located_in the cerebrum."} +{"_id": "1265", "text": "A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system."} +{"_id": "1268", "text": "A chronic lymphocytic leukemia that is characterized by the presence of immature lymphocytes in the blood and bone marrow and/or in the lymph nodes."} +{"_id": "1271", "text": "A mature B-cell neoplasm of B-cells found in the germinal center."} +{"_id": "1274", "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic mesoderm."} +{"_id": "1277", "text": "A parasitic ectoparasitic infectious disease that is caused by parasitic dipterous fly larvae (maggots) feeding on the host's necrotic or living tissue."} +{"_id": "1280", "text": "A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs."} +{"_id": "1283", "text": "A cranio-facial dystonia that is accompanied by blepharospasm."} +{"_id": "1286", "text": "A syndrome characterized by hydrocephalus, spasticity of the lower limbs, adducted thumbs, aphasia, seizures, agenesis of the corpus callosum and intellectual disability in the mild to moderate range."} +{"_id": "1289", "text": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes."} +{"_id": "1292", "text": "An opportunistic mycosis that results_in fungal infection located_in human body, has_material_basis_in Basidiomycota phylum members."} +{"_id": "1295", "text": "A primary systemic mycosis that results_in systemic fungal infection in animals and humans, has_material_basis_in Stachybotrys chartarum, transmitted_by airborne spores and transmitted_by vehicle-borne ingestion and the fungus produces trichothecene mycotoxins including satratoxins causing pulmonary hemorrhage in infants."} +{"_id": "1298", "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters."} +{"_id": "1301", "text": "An adrenal medulla cancer that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin."} +{"_id": "1304", "text": "An anus disease characterized by is an abnormal connection between the epithelialised surface of the anal canal and the perianal skin."} +{"_id": "1307", "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from germ cells."} +{"_id": "1310", "text": "A neurodegenerative disease that is located_in the motor neurones."} +{"_id": "1313", "text": "An angiosarcoma that is located_in the aorta."} +{"_id": "1316", "text": "A carcinoma that is derived_from epithelial cells with finger like projections."} +{"_id": "1319", "text": "A salivary gland cancer that is located_in the sublingual gland."} +{"_id": "1322", "text": "A salivary gland cancer that is located_in the parotid gland."} +{"_id": "1325", "text": "A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord."} +{"_id": "1328", "text": "An autoimmune disease of centreal nervous system caused by an autoimmune response."} +{"_id": "1331", "text": "An autosomal dominant disease that is characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form caused by mutations in a transcript variant of CACNA1C."} +{"_id": "1334", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever."} +{"_id": "1337", "text": "A syndrome that is characterized by advanced bone age, failure to thrive, respiratory problems, dysmorphic facial features, and variable mental retardation."} +{"_id": "1340", "text": "An endocarditis that results from the deposition of small sterile vegetations on valve leaflets."} +{"_id": "1343", "text": "A neonatoal period electroclinical syndrome that is characterized by tonic spasms and partial seizures."} +{"_id": "1346", "text": "An inherited metabolic disorder that involves the creation and degradation of lipids."} +{"_id": "1349", "text": "A parasitic helminthiasis infectious disease that involves infection of the bowel by Hymenolepis nana or Hymenolepis diminuta. The symptoms include diarrhea, gastrointestinal discomfort, itchy anus, poor appetite and weakness."} +{"_id": "1352", "text": "An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell."} +{"_id": "1355", "text": "An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra."} +{"_id": "1358", "text": "A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body."} +{"_id": "1361", "text": "An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place."} +{"_id": "1364", "text": "A Coronaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in coronaviruses, which are transmitted_by droplet spread of respiratory secretions or transmitted_by ingestion of contaminated food."} +{"_id": "1367", "text": "A pancreas adenocarcinoma that has_material_basis_in cells with morphological resemblance to acinar cells and is associated with increased serum lipase."} +{"_id": "1370", "text": "An autosomal recessive disease characterized by abnormal pigmentation of the skin, hair and eyes."} +{"_id": "1373", "text": "A neurodegenerative disease that is characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements."} +{"_id": "1376", "text": "A mitochondrial metabolism disease that has material basis in mutation in the ATP5E gene on chromosome 20q13."} +{"_id": "1379", "text": "A prion disease characterized by adult onset of memory loss, dementia, ataxia, and pathologic deposition of amyloid-like plaques in the brain."} +{"_id": "1382", "text": "A syndrome that involves arachnodactyly, receding lower jaw, and joint laxity limited to the hands and feet."} +{"_id": "1385", "text": "A trichomoniasis that involves infection of the urogenital tract, has_material_basis_in Trichomonas vaginalis, which is transmitted through sexual contact. Symptoms include inflammation of the cervix, urethra and vagina which produce an itching or burning sensation, and yellow-green, itchy, frothy foul-smelling vaginal discharge."} +{"_id": "1388", "text": "A personality disorder that is characterized by paranoia and a pervasive, long-standing suspiciousness and generalized mistrust of others."} +{"_id": "1391", "text": "A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host."} +{"_id": "1394", "text": "A hemiplegia characterized by recurrent episodes of temporary weakness or complete paralysis on one or both sides of the body."} +{"_id": "1397", "text": "A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region."} +{"_id": "1400", "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk."} +{"_id": "1403", "text": "A congenital disorder of glycosylation that involves malfunctioning trimming/processing of the protein-bound oligosaccharide chain."} +{"_id": "1406", "text": "A connective tissue cancer that located_in the pleura."} +{"_id": "1409", "text": "An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus."} +{"_id": "1412", "text": "A vein disease that is characterized by a blood clot that forms within the hepatic portal vein."} +{"_id": "1415", "text": "A prostate carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "1418", "text": "A follicular thyroid carcinoma that has_material_basis_in parafollicular cells."} +{"_id": "1421", "text": "A thalassemia characterized by the reduced or absent synthesis of the beta globin chains of hemoglobin."} +{"_id": "1424", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations."} +{"_id": "1427", "text": "A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM)."} +{"_id": "1430", "text": "A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching."} +{"_id": "1433", "text": "A gamma-amino butyric acid metabolism disorder that is characterized by an excess of homocarnosine in the brain and has_material_basis_in a deficiency of serum carnosinase in its ability to hydrolyze homocarnosine."} +{"_id": "1436", "text": "An anxiety disorder which results from a traumatic experience that results in psychological trauma."} +{"_id": "1439", "text": "An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system."} +{"_id": "1442", "text": "A gallbladder carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "1445", "text": "A rete testis neoplasm that derives_from epithelial cells of glandular origin."} +{"_id": "1448", "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Saffold virus, which is transmitted_by ingestion of food contaminated with feces. The infection has_symptom watery diarrhea, has_symptom fever, has_symptom nausea, and has_symptom vomiting."} +{"_id": "1451", "text": "A syndrome characterized by blepharophimosis, blepharoptosis, highly arched eyebrows hypertelorism, cleft lip and palate, postnatal growth deficiency, cognitive impairment, hearing loss and, in a smaller percentage of cases, craniosynostosis, radioulnar synostosis and genital and vesicorenal anomalies. It encompasses four disorders that were previously designated the Malpuech, Michels, Mingarelli and Carnevale syndromes."} +{"_id": "1454", "text": "An adenoma that is a cystic."} +{"_id": "1457", "text": "A pre-eclampsia that has_symptom at least one of the following: SBP of 160mm HG or higher or DPB of 110mm HG or higher on 2 occasions at least 6 hours apart, proteinuria more than 5g in a 24-hour collection, pulmonary edema or cyanosis, oliguria, persistent headaches, epigastric pain and/or impaired liver function, thrombocytopenia, oligohydramnios, decreased fetal growth or placental abruption."} +{"_id": "1460", "text": "A mitochondrial metabolism disease that has material basis in mutation in the TMEM70 gene on chromosome 8q21."} +{"_id": "1463", "text": "A pituitary gland disease characterized by the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland."} +{"_id": "1466", "text": "An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system."} +{"_id": "1469", "text": "A myeloma and anemia that is located_in some people with diseases that affect the bone marrow."} +{"_id": "1472", "text": "A kidney cancer that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products)."} +{"_id": "1475", "text": "A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting."} +{"_id": "1478", "text": "A Simplexvirus infectious disease that results in inflammatory response by the immune system of the body to Human herpesvirus 1 or Human herpesvirus 2 in the blood, urine, lungs, skin, or other tissues. The symptoms include fever, chills, rapid breathing, and rapid heart rate."} +{"_id": "1481", "text": "An adrenal adenoma that is a benign tumor of the adrenal cortex."} +{"_id": "1484", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea."} +{"_id": "1487", "text": "A Arteriviridae infectious disease that results_in infection in animals, has_material_basis_in Arterivirus."} +{"_id": "1490", "text": "A leukocyte disorder that is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection."} +{"_id": "1493", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Metagonimus yokogawai. The symptoms are diarrhea and colicky abdominal pain. The heart and brain can also be infected."} +{"_id": "1496", "text": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills."} +{"_id": "1499", "text": "A dysgerminoma that is located_in the ovary."} +{"_id": "1502", "text": "A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality."} +{"_id": "1505", "text": "A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus."} +{"_id": "1508", "text": "A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling."} +{"_id": "1511", "text": "A heavy chain disease that results from an overproduction of delta antibody (IgD)."} +{"_id": "1514", "text": "An endocrine system disease that is located_in the gonads."} +{"_id": "1517", "text": "An autosomal recessive disease that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life."} +{"_id": "1520", "text": "A dermatomycosis that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Lacazia loboi and has_symptom crusty plaques, has_symptom tumors and results_in_formation_of nodular lesions."} +{"_id": "1523", "text": "An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system."} +{"_id": "1526", "text": "A cutaneous mycosis that results_in fungal infection located_in skin or of its appendages, has_material_basis_in Ascomycota fungi other than the dermatophytes."} +{"_id": "1529", "text": "An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness."} +{"_id": "1532", "text": "A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly."} +{"_id": "1535", "text": "A carcinoma that results_in a lesion that breaks through the boundary located_in the duct or located_in the lobule."} +{"_id": "1538", "text": "A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate."} +{"_id": "1541", "text": "An impaired renal function disease characterized by a complete or partial resistance of the kidneys to vasopressin (ADH)."} +{"_id": "1544", "text": "An amino acid metabolic disorder that has_material_basis_in defects in the biosynthesis of the amino acid L-serine."} +{"_id": "1547", "text": "An eye and adnexa disease that is located_in the adnexa of the eye."} +{"_id": "1550", "text": "A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles."} +{"_id": "1553", "text": "A pneumoconiosis that involves allergic response located_in lungs caused by inhalation of beryllium compounds."} +{"_id": "1556", "text": "A hypersensitivity reaction type II disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; caused by mutations in the MEFV gene, which encodes the protein pyrin."} +{"_id": "1559", "text": "An inherited metabolic disorder involving dysfunction of pyrimidine metabolism."} +{"_id": "1562", "text": "A viral infectious disease that results_in infection located_in liver, has_material_basis_in Torque teno virus, which is transmitted_by blood transfusion."} +{"_id": "1565", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis."} +{"_id": "1568", "text": "A small intestine carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "1571", "text": "A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities."} +{"_id": "1574", "text": "An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus Penicillium glabrum. The symptoms include dyspnea, wheezing cough, fever and asthenia."} +{"_id": "1577", "text": "A (-)ssRNA virus infectious disease that results_in infection in humans, has_material_basis_in Mononegavirales viruses."} +{"_id": "1580", "text": "A focal dystonia that is characterized as dystonia that affects the muscles of the head, face, and neck."} +{"_id": "1583", "text": "A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly."} +{"_id": "1586", "text": "A inner ear infectious disease which involves inflammation of the labyrinths."} +{"_id": "1589", "text": "An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes."} +{"_id": "1592", "text": "A pancreatic carcinoma that is characterized by its papillary architecture."} +{"_id": "1595", "text": "A plague that results_in infection located_in lung, which results from direct inhalation of the bacillus and has_symptom fever, has_symptom chills, has_symptom cough and has_symptom difficulty breathing."} +{"_id": "1598", "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme resulting in incomplete breakdown of the heparan sulfate sugar chain."} +{"_id": "1601", "text": "A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per \u00b5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS."} +{"_id": "1604", "text": "A mycoplasmal pneumonia that is caused by the bacterial species Mycoplasma pneumoniae. The symptoms include chest pain, chills, dry cough which is not bloody, excessive sweating, fever, headache and sore throat."} +{"_id": "1607", "text": "An amebiasis that involves infection of the skin caused by the parasite Entamoeba histolytica, resulting in lesions on the body."} +{"_id": "1610", "text": "A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "1613", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Colorado tick fever virus which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom stiff neck, has_symptom chills, has_symptom hallucinations, has_symptom disorientation, and has_symptom memory loss."} +{"_id": "1616", "text": "A commensal bacterial infectious disease that is caused by Chlamydia trachomatis."} +{"_id": "1619", "text": "A focal dystonia that is characterized by the involuntary, forcible contraction of the muscles controlling eye blinks."} +{"_id": "1622", "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Varicellovirus."} +{"_id": "1625", "text": "A glucose metabolism disorder that is characterized by chronic haemolytic anaemia, cardiomyopathy, susceptibility to infections and severe neurological dysfunction, and has_physical_basis_in the triosephosphate isomerase enzyme (TPI1) gene inherited as an autosomal recessive trait."} +{"_id": "1628", "text": "A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages."} +{"_id": "1631", "text": "A viral infectious disease that results_in infection, located_in lungs or located_in kidney, has_material_basis_in Hantavirus, which is transmitted_by rodents. The infection has_symptom renal failure, has_symptom hemorrhagic manifestations, and has_symptom pulmonary edema."} +{"_id": "1634", "text": "A coccidiosis that involves infection of the epithelial cells of the small intestine with Cystoisospora belli, which results in nonbloody diarrhea with crampy abdominal pain, malabsorption and weight loss."} +{"_id": "1637", "text": "An aspergillosis that involves fungal infection of the tonsils by Aspergillus species."} +{"_id": "1640", "text": "A spastic cerebral palsy that affects only one limb."} +{"_id": "1643", "text": "A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment."} +{"_id": "1646", "text": "A cerebral palsy that is caused by injury to both the pyramidal and extra pyramidal areas of the brain, which results in both the tight muscle tone and the involuntary movements. The individual have difficulty with speaking and swallowing."} +{"_id": "1649", "text": "A pulmonary tuberculosis in which dissemination of the infection by Mycobacterium tuberculosis has occured to parts of the same lung or the opposite lung through rupture of a caseous lymph node into a bronchus."} +{"_id": "1652", "text": "A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa."} +{"_id": "1655", "text": "A lymphatic system disease that is characterized by an excessive number of histiocytes."} +{"_id": "1658", "text": "A primary bacterial infectious disease that results_in infection located_in skin or located_in mucosa of genital tract, has_material_basis_in Klebsiella granulomatis, transmitted by sexual contact or transmitted_by contact with the open sores. The infection has_symptom painless genital ulcers."} +{"_id": "1661", "text": "An inflammatory bowel disease characterized by inflammation located_in colon and located_in ileum, has_symptom diarrhea, has_symptom weight loss, has_symptom abdominal pain in middle or lower right part."} +{"_id": "1664", "text": "A sarcoma and malignant tumor of extrahepatic bile duct that is located_in the bile duct."} +{"_id": "1667", "text": "A viral infectious disease that results_in infection in ruminants, has_material_basis_in Bluetongue virus, which is transmitted_by Culicoides imicola midge. The infection has_symptom fever, has_symptom excessive salivation, has_symptom swelling of the face and tongue, and has_symptom cyanosis of the tongue."} +{"_id": "1670", "text": "A dsDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Papillomaviridae viruses."} +{"_id": "1673", "text": "An autosomal dominant disease that is characterized by heart arrhythmia defined as a short QT interval on an EKG (less than 300 ms) that does not significantly change with heart rate, tall and peaked T waves, and a structurally normal heart."} +{"_id": "1676", "text": "A beta-lactam allergy triggered by penicillin."} +{"_id": "1679", "text": "An autosomal dominant disease that is characterized by large-joint dislocations and characteristic craniofacial abnormalities."} +{"_id": "1682", "text": "A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information."} +{"_id": "1685", "text": "An intracranial aneurysm with a characteristic rounded shape; the most common form of cerebral aneurysm."} +{"_id": "1688", "text": "A childhood electroclinical syndrome characterized by the occurrence of typical absence seizures starting between the age of four and ten years."} +{"_id": "1691", "text": "A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue."} +{"_id": "1694", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts."} +{"_id": "1697", "text": "An agnosia that is the loss of the ability to recognize objects by touch based on its texture, size and weight."} +{"_id": "1700", "text": "A renal tubular transport disease that is characterized by tubular proteinuria, hypercalciuria, calcium nephrolithiasis, nephrocalcinosis and chronic kidney failure and has_material_basis_in X-linked recessive inheritance of mutations in the CLCN5 gene or OCRL1 gene."} +{"_id": "1703", "text": "A bone disease that results_in formation or resorption abnormalities located_in bone."} +{"_id": "1706", "text": "A lymphoma that begins in cells of the immune system in which different types of lymphoma cells occur at the same time."} +{"_id": "1709", "text": "An anal carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin."} +{"_id": "1712", "text": "A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck."} +{"_id": "1715", "text": "A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache."} +{"_id": "1718", "text": "A muscular dystrophy that is characterized by weakening of the muscles of the hip and shoulders which comprise the limb girdle muscles."} +{"_id": "1721", "text": "A type of ALS caused_by mutation located_in C9ORF72 gene located_in chromosome 9. It is characterized by adult onset of either frontotemporal dementia and/or amyotrophic lateral sclerosis."} +{"_id": "1724", "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Enterovirus, which is transmitted_by direct contact with secretions from an infected person, transmitted_by fomites, transmitted_by droplet spread of oronasal secretions from an infected person, or transmitted_by ingestion of contaminated food."} +{"_id": "1727", "text": "A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as."} +{"_id": "1730", "text": "An ureter carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "1733", "text": "An urogenital tuberculosis that is located_in ureter resulting in ureteral strictures."} +{"_id": "1736", "text": "A candidiasis that results_in fungal infection of the outer-most layer located_in nail, has_material_basis_in Candida species. The infection causes painful, red, swollen area around the nail, often at the cuticle or at the site of a hangnail or other injury."} +{"_id": "1739", "text": "A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis."} +{"_id": "1742", "text": "A nonsyndromic deafness characterized by an X-linked inheritance mode."} +{"_id": "1745", "text": "A gastrointestinal system cancer that is located_in the intestine."} +{"_id": "1748", "text": "An amebiasis that involves infection of the brain caused by the parasite Entamoeba histolytica resulting in brain abscesses."} +{"_id": "1751", "text": "An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal."} +{"_id": "1754", "text": "A skin disease characterized by congenital blistering, skin atrophy, photosensitivity, skin fragility, and scaling."} +{"_id": "1757", "text": "An extraocular retinoblastoma that effects children."} +{"_id": "1760", "text": "A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism."} +{"_id": "1763", "text": "A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo."} +{"_id": "1766", "text": "A rhabdomyosarcoma and sarcoma of liver that are located_in the liver."} +{"_id": "1769", "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed."} +{"_id": "1772", "text": "A skin disease characterized by cutaneous pigmentation, premature graying, dystrophy of the nails, leukoplakia of the oral mucosa, continuous lacrimation due to atresia of the lacrimal ducts, often thrombocytopenia, anemia, testicular atrophy in the male carriers and predisposition to cancer."} +{"_id": "1775", "text": "A glioblastoma multiforme that is characterized by a prevalence of bizarre, multinucleated giant cells."} +{"_id": "1778", "text": "A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the MMP13 gene which results_in a pear-shaped vertebrae, abnormal metaphyseal changes, and genu varum deformities."} +{"_id": "1781", "text": "A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina."} +{"_id": "1784", "text": "An anal carcinoma that represents a group of cancers that are frequently diagnosed in people with HIV/AIDS."} +{"_id": "1787", "text": "A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye; symptoms include vision loss."} +{"_id": "1790", "text": "An American histoplasmosis that results_in inflammation located_in retina, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and results_in_formation_of lesions."} +{"_id": "1793", "text": "An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40."} +{"_id": "1796", "text": "A viral infectious disease that results_in infection located_in respiratory system, located_in gastrointestinal system, and located_in nervous system of dogs, foxes, wolves, coyotes, raccoons, skunks, and ferrets, has_material_basis_in Canine distemper virus, which is transmitted_by droplet spread of respiratory secretions from an infected animal. The infection has_symptom fever, has_symptom nasal discharge, has_symptom coughing, has_symptom vomiting, has_symptom diarrhea, has_symptom seizures, and has_symptom twitching."} +{"_id": "1799", "text": "A sarcoma and malignant tumor of small intestine that is located_in the small intestine."} +{"_id": "1802", "text": "An achromatopsia that is characterized by severely impaired color discrimination, low visual acuity, nystagmus, photophobia due to the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina and has_material_basis_in recessive X-linked inheritance."} +{"_id": "1805", "text": "An aortic disease that is characterized by an absence of an opening from the left ventricle of the heart into the aorta."} +{"_id": "1808", "text": "An urea cycle disorder that involves a mutated and ineffective form of the enzyme ornithine transcarbamylase."} +{"_id": "1811", "text": "A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it."} +{"_id": "1814", "text": "A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts."} +{"_id": "1817", "text": "A liposarcoma that is located_in the larynx."} +{"_id": "1820", "text": "A malignant retroperitoneal cancer and sarcoma that is located_in the retroperitoneal space."} +{"_id": "1823", "text": "A colon cancer that arises from transformed cells of mesenchymal origin and is located_in the colon."} +{"_id": "1826", "text": "A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin."} +{"_id": "1829", "text": "A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva."} +{"_id": "1832", "text": "A Charcot-Marie-Tooth disease characterized by abnormalities in the axon of the peripheral nerve cell."} +{"_id": "1835", "text": "A coccidiosis that involves infection of the intestine with the parasitic protozoan Cyclospora cayetanensis, which is transmitted by contaminated food and water. The symptoms include watery diarrhea, anorexia, weight loss, abdominal pain, nausea and vomiting, myalgias, low-grade fever, and fatigue."} +{"_id": "1838", "text": "A non-Hodgkin lymphoma that has_material_basis_in mature T lymphocytes and natural killer cells."} +{"_id": "1841", "text": "A fibrosarcoma of soft tissue and sarcoma of liver that is located_in the liver."} +{"_id": "1844", "text": "A cutaneous mycosis that results_in fungal infection located_in skin, located_in hair and located_in nail, has_material_basis_in Basidiomycota phylum members."} +{"_id": "1847", "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools."} +{"_id": "1850", "text": "A skin cancer that has_material_basis_in melanocytes."} +{"_id": "1853", "text": "An Epstein-Barr virus infectious disease that results_in inflammation, located_in brain, has_material_basis_in Human herpesvirus 4 and has_symptom seizures, has_symptom altered consciousness, and has_symptom cerebellar ataxia."} +{"_id": "1856", "text": "A syndrome characterize by seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance. It is caused by homozygous or compound heterozygous mutation in the KCNJ10 gene on chromosome 1q23."} +{"_id": "1859", "text": "A breast benign neoplasm comprised of fibrous and glandoular tissues located_in breast."} +{"_id": "1862", "text": "A syndrome characterized by microcornea, microphthalmia, anterior-segment dysgenesis, cataract, coloboma of various parts of the eye, abnormalities of the retinal pigment epithelium, and rod-cone dystrophy and a particular cleft ear lobule."} +{"_id": "1865", "text": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus."} +{"_id": "1868", "text": "A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning."} +{"_id": "1871", "text": "A labyrinthitis induced by alcohol, drug ingestion, or occasionally, inhaled substances that are toxic to the inner ear. Drugs like aminoglycosides, furosemide, ethacrynic acid, acetylsalicyclic acid, amiodarone, quinine, cisplatinum, barbiturates, quinine, anti-Alzheimer's medications, anticonvulsants, antidepressants, and anxiolytics can be ototoxic."} +{"_id": "1874", "text": "A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both."} +{"_id": "1877", "text": "An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face."} +{"_id": "1880", "text": "An extraosseous chondrosarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage and is characterized by a marked abundance of extracellular mucoid (myxoid) matrix."} +{"_id": "1883", "text": "A mediastinal cancer that has_material_basis_in neural cells."} +{"_id": "1886", "text": "An epididymis cancer that derives_from epithelial cells of glandular origin."} +{"_id": "1889", "text": "A skin carcinoma affecting basal cells."} +{"_id": "1892", "text": "An osteochondrosis that results_in death and fracture located_in hip joint."} +{"_id": "1895", "text": "A brain disease characterized by marked reduction of nearly all motor functions including facial expressions, gestures and speech output, but with some degree of alertness."} +{"_id": "1898", "text": "An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column."} +{"_id": "1901", "text": "A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain."} +{"_id": "1904", "text": "A syndrome characterized by intellectual disability, focal dystonia of the hands and dysarthria."} +{"_id": "1907", "text": "A lymphopenia that is caused by a reduction of CD4+ T lymphocytes."} +{"_id": "1910", "text": "A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep."} +{"_id": "1913", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding."} +{"_id": "1916", "text": "A syndrome characterized by childhood hypotonia, a distinctive facial appearance, speech impediments and developmental disability, as well as epilepsy, congenital and urogenetic defects, microcephaly, corpulence, and psychiatric disorders. It is caused either by a microdeletion in the chromosome region 9q34.3 or by a point mutation in the EHMT1 gene located in that region."} +{"_id": "1919", "text": "An asthma that is characterized by chronic nonproductive cough without shortness of breath."} +{"_id": "1922", "text": "A syndrome characterized_by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids, and with alopecia."} +{"_id": "1925", "text": "A Pseudocoelomata infectious disease that involves infection by parasitic worms known as thorny-headed worms, characterized by the presence of an evertable proboscis, armed with spines, which is used to pierce and hold the gut wall of the host."} +{"_id": "1928", "text": "A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles."} +{"_id": "1931", "text": "An aortic valve disease that is characterized by leaking of the aortic valve of the heart causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle."} +{"_id": "1934", "text": "A bipolar disorder that is characterized by at least one hypomanic episode and at least one major depressive episode; with this disorder, depressive episodes are more frequent and more intense than manic episodes."} +{"_id": "1937", "text": "A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable."} +{"_id": "1940", "text": "A cervix carcinoma that has_material_basis_in squamous cells of the cervix."} +{"_id": "1943", "text": "A nervous system cancer that is located_in the peripheral nervous system."} +{"_id": "1946", "text": "A cerebral degeneration characterized by dysfunction of the white matter of the brain."} +{"_id": "1949", "text": "An adrenalcortical carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin."} +{"_id": "1952", "text": "A pulmonary blastoma that derives_from the lung or pleural cavity."} +{"_id": "1955", "text": "A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has_material_basis_in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene."} +{"_id": "1958", "text": "An electroclinical syndrome with onset in infancy occurring between birth and one year of age."} +{"_id": "1961", "text": "A Paramyxoviridae infectious disease that results_in infection in domestic animals and humans, has_material_basis_in Henipavirus, which is transmitted_by direct contact with the urine, feces, and nasal secretions of an infected animal."} +{"_id": "1964", "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, located_in liver, has_material_basis_in Hepeviridae viruses."} +{"_id": "1967", "text": "A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage."} +{"_id": "1970", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine."} +{"_id": "1973", "text": "An intraocular retinoblastoma that effects children."} +{"_id": "1976", "text": "A blepharitis that is characterized by the dual combination of conjunctivitis with blepharitis."} +{"_id": "1979", "text": "An amino acid metabolic disorder that involves deficiency in histidine."} +{"_id": "1982", "text": "A congenital hemolytic anemia characterized by the production of red blood cells with a sphere shape, rather than the normal biconcave disk shape."} +{"_id": "1985", "text": "A choroid plexus cancer that has_material_basis_in epithelial cells of the choroid plexus."} +{"_id": "1988", "text": "An atrophic glossitis that is characterized as an inflammatory condition of the mucous membrane of the tongue, usually on the dorsal surface."} +{"_id": "1991", "text": "An embryoma and malignant neoplasm of lung that derives_from tissues of the lung and derives_from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). It is most commonly effects children."} +{"_id": "1994", "text": "A gonadal dysgenesis that is characterized by a normal 46,XY karyotype along with a progressive loss of germ cells on the developing gonads of an embryo."} +{"_id": "1997", "text": "A toxoplasmosis that is caused by the protozoan Toxoplasma gondii which is recognized as pathogen in immunocompromised patients. Microscopy of the lung shows fibrinous exudate, and necrotic areas with intra and extracellular tachizoites along the interstitium and alveolar spaces. The symptoms are cough, shortness of breath, high fever and rales."} +{"_id": "2000", "text": "A cholera that involves infection of the intestine caused by Vibrio cholerae serogroup O1 biovar El Tor."} +{"_id": "2003", "text": "A acute transudative otitis media involving thick, viscid and mucuslike fluid effusion due to which the drum appears blue in color."} +{"_id": "2006", "text": "A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and necrotizing vasculitis of venules and hemorrhage, and edema."} +{"_id": "2009", "text": "A otitis which involves inflammation of the inner ear."} +{"_id": "2012", "text": "A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord."} +{"_id": "2015", "text": "A Pneumocystis jirovecii pneumonia that is_a disease associated with AIDS has_material_basis_in Pneumocystis jirovecii located_in lungs affecting individuals with HIV."} +{"_id": "2018", "text": "An embryonal cancer that is a type of germ cell tumour that is located_in the ovaries or located_in the testes."} +{"_id": "2021", "text": "An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit."} +{"_id": "2024", "text": "An urethra cancer that is characterized by cancer cells forming in the renal pelvis and ureter."} +{"_id": "2027", "text": "A Flaviviridae infectious disease that results_in infection, has_material_basis_in Hepacivirus, which is transmitted_by sexual contact, or transmitted_by blood transfusion."} +{"_id": "2030", "text": "A sphenoid sinusitis which lasts for less than 4 weeks."} +{"_id": "2033", "text": "An autosomal genetic disease characterized by short stature, bachycephaly and other facial abnormalities, brachydactyly, joint stiffness and distinctive ocular abnormalities."} +{"_id": "2036", "text": "A primary ciliary dyskinesia that results from dysfunction of the cilia during embryologic development and is characterized by the triad of sinusitis, bronchiectasis and situs inversus with dextrocardia."} +{"_id": "2039", "text": "A leukemia that is located_in the spleen. It results_in an enlargement of the leukemia."} +{"_id": "2042", "text": "A pulmonary tuberculosis in which tissue deep in the lungs becomes thick and stiff (scarred)."} +{"_id": "2045", "text": "A connective tissue disease that results in increasing fibrous constriction and ultimately in spontaneous amputation of the toes and especially the little toes. A painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous amputation (autoamputation) a few years later."} +{"_id": "2048", "text": "A primary systemic mycosis that results_in fungal infection located_in skin and located_in subcutaneous tissue, and located_in lymphatic vessel through direct inoculation from wood splinters or hay, has_material_basis_in Sporothrix schenckii, a dimorphic fungus, which results_in_formation_of erythematous papulonodular lesions at the site of implantation and along the lymphangitic channels which soon become palpable and ulcerate."} +{"_id": "2051", "text": "A brain oligodendroglioma located_in the corpus callosum."} +{"_id": "2054", "text": "A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults."} +{"_id": "2057", "text": "A non-suppurative otitis media which involves obstruction of the collecting lymphatic tubules of the middle ear and eustachian tube as they drain to the retropharyngeal lymphatics. Retraction of the tympanic membrane is also observed."} +{"_id": "2060", "text": "A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits."} +{"_id": "2063", "text": "An ovarian cancer that originates in the germ (egg) cells of the ovary."} +{"_id": "2066", "text": "A hematologic cancer and central nervous system neoplasm that is located_in the central nervous system."} +{"_id": "2069", "text": "A genetic disease that is the result of one or more abnormal alleles and may be dominant (a single copy of the abnormal allele is sufficient to give rise to the disease), semi-dominant, or recessive (requiring both copies of the gene to have an abnormal allele)."} +{"_id": "2072", "text": "A malignant glioma that is derived from ependymal cells, a type of glial cell, located_in ventricle lining within the central part of the brain."} +{"_id": "2075", "text": "A malignant neoplasm that is manifested in the pelvic region."} +{"_id": "2078", "text": "A disease that has an etiology of chemical exposure or exposure to other environmental factors excluding infectious agents."} +{"_id": "2081", "text": "An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues."} +{"_id": "2084", "text": "A suppurative otitis media which is persistent and long-lasting."} +{"_id": "2087", "text": "A musculoskeletal system benign neoplasm that is located_in connective tissue."} +{"_id": "2090", "text": "A squamous cell carcinoma that presents as single, isolated cells with bizzare cytoplasmic shapes, intense cytoplasmic eosinophilia, and intensely hyperchromatic, angular nuclei in a background of necrotic and keratinous debris."} +{"_id": "2093", "text": "A crustacean allergy triggered by Litopenaeus vannamei."} +{"_id": "2096", "text": "A viral infectious disease that results_in infection located_in joint, has_material_basis_in O'nyong-nyong virus, which is transmitted_by Anopheles gambiae, and transmitted_by Anopheles funestus mosquitoes. The infection has_symptom fever, has_symptom arthralgia, has_symptom rash, and has_symptom lymphadenitis."} +{"_id": "2099", "text": "A bone development disease that results_in defective ossification of located_in bone."} +{"_id": "2102", "text": "A viral infectious disease that results_in infection located_in joint, has_material_basis_in Barmah Forest virus, which is transmitted_by mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash."} +{"_id": "2105", "text": "A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection."} +{"_id": "2108", "text": "An autosomal dominant disease that is characterized by multiple bluish cutaneous or mucosal venous lesions."} +{"_id": "2111", "text": "A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years."} +{"_id": "2114", "text": "A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage."} +{"_id": "2117", "text": "An anogenital venereal wart that results_in infection located_in skin of anus, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during anal sex with an infected partner. The infection has_symptom anal warts."} +{"_id": "2120", "text": "A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies."} +{"_id": "2123", "text": "A superficial mycosis that results_in fungal infection of the outermost layer located_in skin and located_in hair shaft, has_material_basis_in Basidiomycota phylum members."} +{"_id": "2126", "text": "An epilepsy that is characterized by frequent febrile seizures with onset before 1 year."} +{"_id": "2129", "text": "A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia."} +{"_id": "2132", "text": "An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located_in the cells that line the blood vessels within the breast or underarm area."} +{"_id": "2135", "text": "A food allergy triggered by a plant fruit product."} +{"_id": "2138", "text": "An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons."} +{"_id": "2141", "text": "A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis."} +{"_id": "2144", "text": "A parasitic protozoa infectious disease that involves infection caused by a free-living ameba Balamuthia mandrillaris resulting in encephalitis and skin lesions in humans and animals."} +{"_id": "2147", "text": "A ciliopathy that is characterized by renal cystic dysplasia, occipital encephalocele, polydactyly (post axial), hepatic developmental defects, and pulmonary hypoplasia."} +{"_id": "2150", "text": "A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity."} +{"_id": "2153", "text": "An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located_in the liver."} +{"_id": "2156", "text": "A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods."} +{"_id": "2159", "text": "A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences."} +{"_id": "2162", "text": "A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together."} +{"_id": "2165", "text": "A rectum cancer that derives_from epithelial cells of glandular origin."} +{"_id": "2168", "text": "A gastrointestinal benign neoplasm that is a located_in the salivary glands."} +{"_id": "2171", "text": "A purine-pyrimidine metabolic disorder characterized by deficiency of xanthine oxidase, resulting in excretion of large amounts of xanthine in the urine and the formation of xanthine stones."} +{"_id": "2174", "text": "A yaws that results in initial papule at the site of entry of bacteria. Without treatment, this is followed by disseminated skin lesions over the body. Bone pain and bone lesions may also occur."} +{"_id": "2177", "text": "A leprosy that results in small numerous red irregularly shaped plaques."} +{"_id": "2180", "text": "An artery disease that is characterized by degeneration of the cells composing the aortic wall."} +{"_id": "2183", "text": "A sleep disorder that involves recurring bouts of excessive amounts of sleepiness."} +{"_id": "2186", "text": "An organ system cancer located_in the ear and characterized by uncontrolled cellular proliferation of the auditory organs."} +{"_id": "2189", "text": "Emphysematous cholecystitis is a bacterial infectious disease consisting of an inflammation of the gallbladder characterized by air-filled expansions in interstitial or subcutaneous tissues."} +{"_id": "2192", "text": "A type of ALS with juvenile onset caused_by homozygous or compound heterozygous mutation in the spatacsin gene (SPG11) on chromosome 15q21."} +{"_id": "2195", "text": "A gastrointestinal system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct."} +{"_id": "2198", "text": "A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of Toxocara canis or Toxocara cati. The larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions."} +{"_id": "2201", "text": "A gallbladder carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "2204", "text": "A non-suppurative otitis media and eustachian tube disorder with a sudden onset and a short course."} +{"_id": "2207", "text": "An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness."} +{"_id": "2210", "text": "A colon carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "2213", "text": "A heavy chain disease that results from an overproduction of gamma antibody (IgG)."} +{"_id": "2216", "text": "A lipid storage disease that is characterized by the desposition of yellowish cholesterol-rich material in tendons or other body parts."} +{"_id": "2219", "text": "An aspiration pneumonia caused by anaerobic bacteria like Bacteroides fragilis, Peptostreptococcus, anaerobic streptococci, Fusobacterium species (Fusobacterium nucleatum and Fusobacterium necrophoram). Lung abscess and empyema are diagnosed in this disease."} +{"_id": "2222", "text": "A lymph node cancer that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures of the lymph nodes. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes."} +{"_id": "2225", "text": "A synovium cancer which develops in the synovial membrane of the joints."} +{"_id": "2228", "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse."} +{"_id": "2231", "text": "A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use."} +{"_id": "2234", "text": "An artery disease that is characterized by dysfunction of the blood vessels supplying the brain."} +{"_id": "2237", "text": "A tyrosinemia that has_material_basis_in deficiency of the enzyme fumarylacetoacetate hydrolase resulting in an increase in fumarylacetoacetate which inhibits previous steps in tyrosine degradation leading to an accumulation of tyrosine in the body."} +{"_id": "2240", "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis."} +{"_id": "2243", "text": "A gastrointestinal system disease that is located_in the esophagus."} +{"_id": "2246", "text": "A Varicellovirus infectious disease that results_in pain located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after the primary infection, has_symptom severe pain, has_symptom sensitivity to light touch, has_symptom muscle weakness, has_symptom paralysis, and has_symptom itching."} +{"_id": "2249", "text": "A spina bifida characterized by protrusion of the spinal cord through an opening, covered by meningeal membranes."} +{"_id": "2252", "text": "An upper respiratory tract disease which involves inflammation of both larynx and pharynx."} +{"_id": "2255", "text": "A gastrointestinal system cancer that has_material_basis_in epithelial cells."} +{"_id": "2258", "text": "A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia."} +{"_id": "2261", "text": "A neurilemmoma with a predominantly cellular growth but no Verocay bodies."} +{"_id": "2264", "text": "Encephalitis is a nervous system infectious disease characterized as an acute inflammation of the brain. The usual cause is a viral infection, but bacteria can also cause it. Cases can range from mild to severe. For mild cases, you could have flu-like symptoms. Serious cases can cause severe headache, sudden fever, drowsiness, vomiting, confusion and seizures."} +{"_id": "2267", "text": "A chondrosarcoma that is located_in exclusively soft tissue."} +{"_id": "2270", "text": "An autosomal recessive disease that is a genetically heterogeneous encephalopathy characterized in its most severe form by cerebral atrophy, leukodystrophy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infections."} +{"_id": "2273", "text": "A selective immunoglobulin deficiency disease thatis a dysgammaglobulinemia resulting from decreased levels of immunoglobulin M (IgM) production to roduction of other antibodies."} +{"_id": "2276", "text": "A vaginal cancer that has_material_basis_in epithelial cells."} +{"_id": "2279", "text": "A nephroblastoma that recurs over time."} +{"_id": "2282", "text": "A syndrome that affects growth, cranial development, hair growth and dental development."} +{"_id": "2285", "text": "An adrenal admenoma characterized by over production of aldosterone."} +{"_id": "2288", "text": "An American histoplasmosis that results_in inflammation located_in pericardium, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom pleural effusions, has_symptom chest pain and has_symptom cough."} +{"_id": "2291", "text": "A connective tissue benign neoplasm that is characterized by the development of benign tumors in the skin, striated muscles, bones, and in exceptional cases, visceral organs."} +{"_id": "2294", "text": "A dysostosis characterized by cranium bifidum, severe hypertelorism, median cleft lip and palate, nasal bifurcation, brachycephaly, large fontanelle, tibial hemimelia, preaxial polydactyly of the feet and brain malformations."} +{"_id": "2297", "text": "A candidiasis that results_in inflammation located_in endocardium, has_material_basis_in Candida, which favors previously damaged or prosthetic heart valves. The source is often an intravascular catheter or contaminated equipment used for illicit intravenous drug injection. The illness has_symptom fever, has_symptom murmur, has_symptom congestive heart failure, has_symptom anemia, and has_symptom splenomegaly."} +{"_id": "2300", "text": "A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium."} +{"_id": "2303", "text": "A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop)."} +{"_id": "2306", "text": "An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent."} +{"_id": "2309", "text": "A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system."} +{"_id": "2312", "text": "A tertiary syphilis that is caused by the spirochetal bacterium Treponema pallidum subspecies pallidum. It is a sexually transmitted disease although congenital syphilis can also occur. Treponema infection of the lung leads to a fibrous induration spreading from the roots of the lungs. Ulcerations occur in the superficial tissues, while in the deep tissues gummata are formed. Symptoms include dry cough, hemoptysis, hemorrhage, dyspnea, pain in the chest, loss of weight and slight fever."} +{"_id": "2315", "text": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior."} +{"_id": "2318", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi . Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur."} +{"_id": "2321", "text": "An embryonal cancer and bone cancer and mesenchymal cell neoplasm that is located_in the notochord."} +{"_id": "2324", "text": "A germ cell cancer that derives_from cells that give rise to egg cells."} +{"_id": "2327", "text": "A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint."} +{"_id": "2330", "text": "An X-linked disease characterized by pre- and postnatal overgrowth and craniofacial, skeletal, cardiac and renal abnormalities."} +{"_id": "2333", "text": "A tularemia that results_in bacteremia and has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom malaise, and has_symptom weight loss."} +{"_id": "2336", "text": "A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis."} +{"_id": "2339", "text": "An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea."} +{"_id": "2342", "text": "An ancylostomiasis that involves parasitic infection of animals and humans by Ancylostoma ceylanicum larvae, which invade percutaneously and migrate to the intestine."} +{"_id": "2345", "text": "A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH)."} +{"_id": "2348", "text": "An acrodermatitis characterized by a chronically progressive course, leading to widespread atrophy of the skin. It is a clinical manifestation of Lyme borreliosis."} +{"_id": "2351", "text": "A pineal gland neoplasm located_in the brain."} +{"_id": "2354", "text": "An integumentary system disease that is located_in hair."} +{"_id": "2357", "text": "A Varicellovirus infectious disease that results_in infection in cattle, located_in upper respiratory tract, and located_in genital tract, has_material_basis_in Bovine herpesvirus 1, has_symptom nasal discharge, has_symptom fever, has_symptom abortion, and has_symptom conjunctivitis."} +{"_id": "2360", "text": "A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide."} +{"_id": "2363", "text": "An external ear cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "2366", "text": "A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities."} +{"_id": "2369", "text": "A dystonia that affects two or more adjacent parts of the body."} +{"_id": "2372", "text": "A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption."} +{"_id": "2375", "text": "A fruit allergy triggered by Cucumis melo plant fruit food product."} +{"_id": "2378", "text": "A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated."} +{"_id": "2381", "text": "A fruit allergy triggered by Prunus armeniaca plant fruit food product."} +{"_id": "2384", "text": "A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent."} +{"_id": "2387", "text": "An egg allergy triggered by Gallus gallus eggs."} +{"_id": "2390", "text": "A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system."} +{"_id": "2393", "text": "A syndromic intellectual characterized by an X-linked inheritance pattern."} +{"_id": "2396", "text": "A coxsackie meningitis that results_in inflammation located_in meningeal cluster, has_material_basis_in Human echovirus 30, or has_material_basis_in Human echovirus 9, which is transmitted_by ingestion of food contaminated with feces, transmitted_by droplet spread of oronasal secretions from infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom headache, has_symptom photophobia and has_symptom neck stiffness."} +{"_id": "2399", "text": "A otitis media which involves inflammation of the middle ear with infected effusion containing pus."} +{"_id": "2402", "text": "A drug allergy triggered by a beta-lactam (\u03b2-lactam)."} +{"_id": "2405", "text": "A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body."} +{"_id": "2408", "text": "An autosomal recessive disease that is characterized by the combination of hypertelorism, cleft lip and palate and microtia."} +{"_id": "2411", "text": "A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration."} +{"_id": "2414", "text": "A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure."} +{"_id": "2417", "text": "A bone marrow cancer that results_in the overproduction of white blood cells."} +{"_id": "2420", "text": "A myeloma and blood platelet disease that is characterized by the presence of high platelet counts in the blood."} +{"_id": "2423", "text": "A calcinosis that is the calcification or a bony hardening of ligaments in areas where they attach to your spine."} +{"_id": "2426", "text": "A sideroblastic anemia characterized by an autosomal dominant inheritance pattern."} +{"_id": "2429", "text": "An embryonal testis carcinoma that occurs in children."} +{"_id": "2432", "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "2435", "text": "An actinomycosis that results_in infection, has_material_basis_in Actinomyces israelii or has_material_basis_in Actinomyces gerencseriae. It results in lung cavities, lung nodules, and pleural effusion. The infection has_symptom chest pain, has_symptom cough with sputum, has_symptom fever, has_symptom lethargy, has_symptom night sweats, has_symptom shortness of breath, has_symptom weight loss, and has_symptom draining of sinuses."} +{"_id": "2438", "text": "A mitochondrial metabolism disease characterized by motor disability, with ataxia, apraxia, dystonia, and dysarthria, associated with necrotic lesions throughout the brain and has material basis in mutation in the TTC19 gene on chromosome 17. It has an autosomal recessive inheritance pattern."} +{"_id": "2441", "text": "A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens."} +{"_id": "2444", "text": "A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage."} +{"_id": "2447", "text": "An endocervical carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "2450", "text": "A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria)."} +{"_id": "2453", "text": "A T cell deficiency disease that is the result of a large deletion of chromosome 22 which includes the DGS gene needed for development of the thymus and related glands with subsequent lack of T-cell production."} +{"_id": "2456", "text": "A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries."} +{"_id": "2459", "text": "A eustachian tube disorder with a wider eustachian tube which allows a larger bolus of bacteria-laden material from the nasopharynx during an infection to enter the middle ear, causing a more fulminant infection."} +{"_id": "2462", "text": "A B cell deficiency that is caused by a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement."} +{"_id": "2465", "text": "A respiratory system disease which involves the upper respiratory tract."} +{"_id": "2468", "text": "A germ cell cancer that derives_from germ cells that are found in areas of the body other than the ovary or testicle. The tumors originate in the sperm forming cells in the testicles or egg producing cells in the ovary."} +{"_id": "2471", "text": "A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death."} +{"_id": "2474", "text": "A transitional cell carcinoma that has sarcoma-like components arising from the malignant transitional epithelium."} +{"_id": "2477", "text": "A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality."} +{"_id": "2480", "text": "A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope."} +{"_id": "2483", "text": "A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly."} +{"_id": "2486", "text": "A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching."} +{"_id": "2489", "text": "A globe disease that is characterized by inflammation of the inside of the eye."} +{"_id": "2492", "text": "A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot."} +{"_id": "2495", "text": "An osteosclerosis that results_in numerous bone islands located_in skeleton."} +{"_id": "2498", "text": "A pervasive developmental disease that is a neurological and developmental disorder that mostly occurs in females and is caused_by a mutation on the MECP2 gene on the X chromosome. Infants with Rett syndrome seem to grow and develop normally at first, but then stop developing and even lose skills and abilities."} +{"_id": "2501", "text": "A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch."} +{"_id": "2504", "text": "A chondroid chordoma and chordoma of the clivus that is located_in the clivus."} +{"_id": "2507", "text": "A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality."} +{"_id": "2510", "text": "An anthrax disease that results_in infection located_in lung lymph nodes brought on by breathing in the spores of the bacteria Bacillus anthracis. The first symptoms of inhalation anthrax are like cold or flu symptoms and can include a sore throat, mild fever and muscle aches. Later symptoms include cough, chest discomfort, shortness of breath, tiredness and muscle aches."} +{"_id": "2513", "text": "An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. It is caused by mutations in the GNAS1 gene."} +{"_id": "2516", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis."} +{"_id": "2519", "text": "A hereditary ataxia characterized by sporadic bouts of ataxia with or without continuous muscle movement."} +{"_id": "2522", "text": "A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by fungal infection in immunocompromised patients."} +{"_id": "2525", "text": "A thyroid cancer that is located_in the supporting cells of the thyroid."} +{"_id": "2528", "text": "A larynx cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic mesoderm."} +{"_id": "2531", "text": "A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting."} +{"_id": "2534", "text": "An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs."} +{"_id": "2537", "text": "An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions."} +{"_id": "2540", "text": "An eccrine sweat gland cancer that derives_from epithelial cells of glandular origin."} +{"_id": "2543", "text": "A dermatitis that is an inflammatory skin condition resulting in flaky, white to yellowish scales on oily areas such as the scalp or inside the ear, which is caused due to a combination of an over production of skin oil and irritation from a yeast Malassezia furfur. The symptoms include itching, skin lesions and scales, redness, plaques and hair loss."} +{"_id": "2546", "text": "Motility-related diarrhea is a diarrhea which is caused by the rapid movement of food through the intestines (hypermotility). If the food moves too quickly through the GI tract, there is not enough time for sufficient nutrients and water to be absorbed."} +{"_id": "2549", "text": "An opportunistic mycosis that results_in fungal infection located_in nail, has_material_basis_in Scopulariopsis brevicaulis and has_symptom rough nail, and has_symptom crumbly nail which can separate from the nail bed."} +{"_id": "2552", "text": "A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells."} +{"_id": "2555", "text": "A bone disease that results_in inflammation of the located_in bone."} +{"_id": "2558", "text": "A xanthomatosis that is characterized by a deficiency in the production of the bile acid, chenodeoxycholic acid that has_material_basis_in autosomal recessive inheritance and results in cholestanol deposition in the brain and other tissues and with elevated levels of cholesterol in plasma."} +{"_id": "2561", "text": "An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges."} +{"_id": "2564", "text": "A germinoma that has_material_basis_in cells that make sperm and eggs."} +{"_id": "2567", "text": "An extrinsic allergic alveolitis which is caused by inhalation of fungal spores of Aspergillus clavatus and Aspergillus fumigatus from moldy barley."} +{"_id": "2570", "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system."} +{"_id": "2573", "text": "An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids."} +{"_id": "2576", "text": "An Enterovirus infectious disease that results_in inflammation located_in brain, has_material_basis_in polioviruses, which are transmitted_by ingestion of food contaminated with feces. The infection has_symptom tremors, has_symptom nystagmus, has_symptom loss of conjugate eye movements, has_symptom muscle rigidity, has_symptom hemiparesis, and has_symptom coma."} +{"_id": "2579", "text": "A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with cysts and papillary endophytic projections."} +{"_id": "2582", "text": "A hypobammaglobulinemia that is a B cell deficiency caused by a mutation a cytoplasmic linker or adaptor protein that plays a critical role in B cell development, the B cell linker protein (BLNK) gene. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. The BLNK gene is associated with intracellular calcium mobilization, essential for cell activation."} +{"_id": "2585", "text": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body."} +{"_id": "2588", "text": "A uterine body mixed cancer that has_material_basis_in both endometrial carcinoma and sarcoma."} +{"_id": "2591", "text": "A viral infectious disease that results_in infection, has_material_basis_in Rubella virus, which is transmitted_by direct contact with the infected person through coughing and sneezing, and transmitted_by congenital method."} +{"_id": "2594", "text": "A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions."} +{"_id": "2597", "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain."} +{"_id": "2600", "text": "A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue forming serous lesions."} +{"_id": "2603", "text": "A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes."} +{"_id": "2606", "text": "A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible."} +{"_id": "2609", "text": "A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth."} +{"_id": "2612", "text": "An angiosarcoma that affects children."} +{"_id": "2615", "text": "A syndrome characterized by classical lissencephaly and distinct facial features. Visible and submicroscopic deletions of 17p13.3, including the LIS1 gene, are found in almost 100% of patients."} +{"_id": "2618", "text": "A primary systemic mycosis that results_in fungal infection located_in lung, has_material_basis_in Sporothrix schenckii, a dimorphic fungus, which is transmitted_by airborne spores and has_symptom productive cough, has_symptom nodules and cavitations of the lungs, has_symptom fibrosis, and has_symptom swollen hilar lymph nodes."} +{"_id": "2621", "text": "A"} +{"_id": "2624", "text": "An eosinophilic pneumonia described as a form of pulmonary eosinophilia characterized as a mild pneumonitis marked by transitory pulmonary infiltration and eosinophilia and usually considered to be an allergic reaction. It can occur in response to a parasitic infection."} +{"_id": "2627", "text": "A brain cancer that has_material_basis_in glial cells."} +{"_id": "2630", "text": "A nephroblastoma that results_in an unfavorable appearance under the microscope. They are characterized by a cell nuclei that tends to be very large and distorted."} +{"_id": "2633", "text": "A leiomyosarcoma and sarcoma of the mediastinum that derive_from smooth muscle and are usually located_in the esophagus or located_in the main vessels."} +{"_id": "2636", "text": "A gallbladder sarcoma that is located_in the gallbladder."} +{"_id": "2639", "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Caliciviridae viruses."} +{"_id": "2642", "text": "A salivary gland carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes."} +{"_id": "2645", "text": "A ssDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Parvoviridae viruses."} +{"_id": "2648", "text": "A liposarcoma that is located_in the kidney."} +{"_id": "2651", "text": "A genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature."} +{"_id": "2654", "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which produce mucin."} +{"_id": "2657", "text": "A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood."} +{"_id": "2660", "text": "A non-small cell lung carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "2663", "text": "A carcinoma that is able to grow at sites distant from the primary site of origin."} +{"_id": "2666", "text": "A syndrome that is characterized by congenital joint contractures, renal tubular dysfunction, cholestasis, severe failure to thrive, ichthyosis, and a defect in platelet alpha-granule biogenesis, caused_by homozygous or compound heterozygous mutation located_in VPS33B gene or caused_by homozygous or compound heterozygous mutation in the VIPAR gene on chromosome 14q24.3.."} +{"_id": "2669", "text": "An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop."} +{"_id": "2672", "text": "A germ cell cancer that occurs in many forms."} +{"_id": "2675", "text": "An idiopathic interstitial pneumonia which involves diffuse interstitial infiltration of involved areas mostly with T lymphocytes, plasma cells, and macrophages. Lymphoid hyperplasia is frequently seen. Onset is often slow with gradually increasing cough and breathlessness over 3 or more years. Fever, weight loss, chest pain, and arthralgia are occasionally found. Crackles may be detected as the disease progresses."} +{"_id": "2678", "text": "A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds."} +{"_id": "2681", "text": "A Q fever that involves inflammation of the liver caused by Coxiella burnetti, which results in the formation of granulomas. The symptoms include fever, malaise, hepatomegaly with right upper abdominal pain, and jaundice."} +{"_id": "2684", "text": "A spotted fever that has_material_basis_in Rickettsia honei, which is transmitted_by cayenne ticks (Amblyomma cajennense). The infection has_symptom mild spotted fever, has_symptom eschar and has_symptom adenopathy."} +{"_id": "2687", "text": "A bone cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "2690", "text": "An idiopathic interstitial pneumonia that is characterized by the accumulation of bronchiolocentric alveolar macrophages in alveolar spaces and interstitial inflammation and involves mild bronchiolar fibrosis and chronic inflammation."} +{"_id": "2693", "text": "A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia."} +{"_id": "2696", "text": "A hypersensitivity reaction type IV disease that results from a proliferation of cells producing immunoglobulin heavy chains."} +{"_id": "2699", "text": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences."} +{"_id": "2702", "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Inkoo virus, which is transmitted_by Ochlerotatus communis mosquito. The infection has_symptom stiff neck, has_symptom lethargy, has_symptom headache, has_symptom fever, and has_symptom seizures."} +{"_id": "2705", "text": "Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself."} +{"_id": "2708", "text": "A (-)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Orthomyxoviridae family viruses, which are transmitted_by droplet spread of respiratory secretions or transmitted_by contaminated fomites."} +{"_id": "2711", "text": "A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications."} +{"_id": "2714", "text": "A Paramyxoviridae infectious disease that results_in infection in dogs, seals, cattle and humans, has_material_basis_in Morbillivirus."} +{"_id": "2717", "text": "A leukemia that has_material_basis_in lymphoblasts (immature white blood cells)."} +{"_id": "2720", "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the prostate gland caused by Trichomonas vaginalis."} +{"_id": "2723", "text": "A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum."} +{"_id": "2726", "text": "A nonparalytic poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 2, which is transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms."} +{"_id": "2729", "text": "A vascular disease that is located_in a vein."} +{"_id": "2732", "text": "A congenital heart disease characterized by abnormal development of the left-sided structures of the heart."} +{"_id": "2735", "text": "An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs."} +{"_id": "2738", "text": "A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance."} +{"_id": "2741", "text": "An enteroinvasive Escherichia coli infectious disease that involves infection of the intestine caused by enteroinvasive Escherichia coli. The symptoms include fever, bloody diarrhea, and dehydration."} +{"_id": "2744", "text": "An autosomal recessive disease characterized by sun sensitivity, short stature, predisposition to the development of cancer and genomic instability."} +{"_id": "2747", "text": "Paronychia is a nail infectious disease where there is an often-tender bacterial or fungal hand infection or foot infection due to either bacteria or fungus (Candida albicans) where the nail and skin meet at the side or the base of a finger or toe nail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia). Puss is usually present, along with gradual thickening and browning discoloration of the nail plate."} +{"_id": "2750", "text": "A pneumonia accompanied by inflammation of the pleura and accumulation of pus in the pleural space caused by bacteria."} +{"_id": "2753", "text": "A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells."} +{"_id": "2756", "text": "A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions."} +{"_id": "2759", "text": "An acquired immunodeficiency syndrome that results_in involuntary loss of more than 10% of body weight, plus more than 30 days of either diarrhea, or weakness and fever, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2."} +{"_id": "2762", "text": "A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion."} +{"_id": "2765", "text": "A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and is caused by mutations in the CTNS gene, located on chromosome 17."} +{"_id": "2768", "text": "A rhinitis which involves a hypersensitive reaction to various potentially irritating stimuli such as changes in weather, temperature, or barometric pressure, chemical irritants such as smoke, ozone, pollution, perfumes, and aerosol sprays, psychological stress and emotional shocks, medications, alcohol, and spicy food."} +{"_id": "2771", "text": "A sarcoma and malignant tumor of rectum that is located_in the rectum."} +{"_id": "2774", "text": "A Rhabditida infectious disease that involves parasitic infection of gastrointestinal tracts of ruminants, horses, cats, dogs, swine and humans by nematodes belonging to the suborder Strongylida."} +{"_id": "2777", "text": "A chordoma that is located_in the skull base."} +{"_id": "2780", "text": "A bovine respiratory disease complex which is an infectious disease in calves involving stress and possibly an initial respiratory viral infection followed by a secondary bacterial infection of the lower respiratory tract. Mycoplasmal and bacterial agents including Pasteurella multocida, Mannheimia haemolytica, and Mycoplasma bovis represent the most frequently isolated pathogenic organisms."} +{"_id": "2783", "text": "A subcutaneous mycosis that involves fungal infection of the subcutaneous tissue caused by members of the order Entomophthorales."} +{"_id": "2786", "text": "A hypersensitivity reaction type I disease located in the respiratory tract."} +{"_id": "2789", "text": "A leukemia that is in between acute and chronic leukemia and is characterized by a moderate duration or severity."} +{"_id": "2792", "text": "A parasitic helminthiasis infectious disease that involves infection by parasitic roundworms including ascarids, filarids, hookworms, pinworms, and whipworms."} +{"_id": "2795", "text": "A viral infectious disease that results_in infection in cattle and swine, has_material_basis_in Foot-and-mouth disease virus, which is transmitted_by contaminated fomites, or transmitted_by ingestion of food contaminated with infected meat or animal products. The infection results_in_formation_of vesicles in the mouth, or on the feet and has_symptom lameness."} +{"_id": "2798", "text": "A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries."} +{"_id": "2801", "text": "A monogenic disease that has_material_basis_in muations on the Y chromosome."} +{"_id": "2804", "text": "A type of ALS caused_by mutation located_in UBQLN 2 gene located_in X chromosome."} +{"_id": "2807", "text": "A fibrosarcoma that is located_in the dermis laryer of the skin and that begins as a hard nodule and grows slowly."} +{"_id": "2810", "text": "A viral infectious disease that results_in infection in horses, mules, donkeys and zebras located_in lung, has_material_basis_in African horsesickness virus, which is transmitted_by biting midge, Culicoides imicola, transmitted_by Culex mosquito, transmitted_by Anopheles mosquito, transmitted_by Aedes mosquito, transmitted_by Hyalomma tick, and transmitted_by Rhipicephalus tick. The infection has_symptom tachypnea, has_symptom forced expiration, has_symptom profuse sweating, has_symptom spasmodic coughing, and has_symptom ecchymoses on the tongue."} +{"_id": "2813", "text": "A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa."} +{"_id": "2816", "text": "A filarial elephantiasis that involves parasitic infection by the nematode Brugia malayi, which inhabits the lymphatics. The symptoms include fever, lymphadenitis, lymphangitis, lymphedema, and secondary bacterial infection."} +{"_id": "2819", "text": "A coxsackie carditis that results_in inflammation located_in pericardium, has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom acute chest pain, has_symptom disturbance of heart rate, and has_symptom dyspnea."} +{"_id": "2822", "text": "A leukemia that is located_in myeloid tissue."} +{"_id": "2825", "text": "A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone."} +{"_id": "2828", "text": "An ampulla of Vater carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "2831", "text": "A dsDNA virus infectious disease that results_in infection in pigs, has_material_basis_in Asfarviridae viruses, which are transmitted_by soft tick bite."} +{"_id": "2834", "text": "A Joubert syndrome subtype with orofaciodigital defect."} +{"_id": "2837", "text": "A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates."} +{"_id": "2840", "text": "A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot."} +{"_id": "2843", "text": "A disease that involving errors in metabolic processes of building or degradation of molecules."} +{"_id": "2846", "text": "An acute stress disorder that involves neurotic reactions to unusual, severe, or overwhelming military stress."} +{"_id": "2849", "text": "An alveolar soft part sarcoma and vulvar sarcoma that is located_in the vulva."} +{"_id": "2852", "text": "A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast."} +{"_id": "2855", "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Flavivirus, which causes encephalitis or hemorrhagic fever in humans and transmitted_by arthropod vectors or transmitted_by contact with infected animal carcasses."} +{"_id": "2858", "text": "A mansonelliasis that involves parasitic infection by the nematode Mansonella ozzardi, which resides in the subcutaneous tissues causing arthralgias, headaches, fever, pulmonary symptoms, adenopathy, hepatomegaly, and pruritus. Both midges and blackflies transmit the disease."} +{"_id": "2861", "text": "A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all."} +{"_id": "2864", "text": "A viral infectious disease that results_in ulceration located_in intestinal epithelium of cats, which has_material_basis_in Feline panleukopenia virus, transmitted_by contact with an infected cat's bodily fluids, feces, or fleas. The infection has_symptom bloody diarrhea, has_symptom dehydration, has_symptom anemia, and has_symptom vomiting."} +{"_id": "2867", "text": "An agnosia that is a loss of the ability to perceive facial expression, body language and intonation, rendering them unable to non-verbally perceive people's emotions and limiting that aspect of social interaction."} +{"_id": "2870", "text": "A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection."} +{"_id": "2873", "text": "A pulmonary tuberculosis that is characterized by filling of airspaces with fluid, inflammatory exudates (pus, proteins and immunological substances) or cells (malignant cells and red blood cells) in a region of the lung."} +{"_id": "2876", "text": "A food allergy that results in adverse immune reaction to one or more of the proteins in cow's milk and/or the milk of other animals, which are normally harmless to the non-allergic individual."} +{"_id": "2879", "text": "A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity."} +{"_id": "2882", "text": "An opportunistic mycosis that has_material_basis_in Galactomyces geotrichum, results_in systemic infection in immunocompromised people."} +{"_id": "2885", "text": "A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause."} +{"_id": "2888", "text": "A syndrome characterized by mild to moderate short stature due to growth delays after birth, distinctive craniofacial abnormalities, skeletal malformations and genital abnormalities."} +{"_id": "2891", "text": ".A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene."} +{"_id": "2894", "text": "A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia."} +{"_id": "2897", "text": "An organic acidemia that involes a nonfunctional propionyl CoA carboxylase affecting conversion of aminio acids and fats into sugar for energy."} +{"_id": "2900", "text": "An agnosia that involves a severe problem with recalling words or names."} +{"_id": "2903", "text": "An actinomycosis that results_in infection located_in skin, has_material_basis_in Actinomyces israelii, which invades the soft tissue resulting in the formation of abnormal channels leading to the skin surface (external sinus tracts) that discharge pale yellow sulfur granules."} +{"_id": "2906", "text": "An adult sarcoma of soft tissue and synovial sarcoma that affects non-epithelial, extraskeletal tissue of the body, including the muscle, fat, fibrous tissue, vessels and peripheral nervous system."} +{"_id": "2909", "text": "An anomalous configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system."} +{"_id": "2912", "text": "A urinary system disease that is located_in the ureter."} +{"_id": "2915", "text": "A cervical carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "2918", "text": "A glioblastoma multiforme that is characterized by the expression of several gene types that are also typical of the brain's normal, noncancerous nerve cells, or neurons."} +{"_id": "2921", "text": "An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection."} +{"_id": "2924", "text": "A respiratory system cancer that is located_in the nasal cavity."} +{"_id": "2927", "text": "A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis."} +{"_id": "2930", "text": "A leprosy that results in one erythematous large plaque with well-defined borders that are elevated and that slope down into an atrophic center."} +{"_id": "2933", "text": "A otitis media which is an expansile, inflammatory mass of granulation tissue in the middle ear. It is a foreign body reaction to cholesterol deposits that occur in obstructed fluid-filled air cells of the temporal bone. It is present with a conductive hearing loss and a blue eardrum."} +{"_id": "2936", "text": "A hereditary spastic paraplegia that is characterized by spasticity of the leg muscles, progressive muscle weakness, paraplegia, muscle wasting in the hands and feet (distal amyotrophy), small stature, developmental delay, learning disorders, speech difficulties (dysarthria), and mood swings, and has_material_basis_in a mutation of the SPG20 gene."} +{"_id": "2939", "text": "A viral infectious disease that results_in infection in humans, has_material_basis_in Mumps virus, which is transmitted_by contact with the oronasal secretions of an infected person."} +{"_id": "2942", "text": "A macular degeneration that can cause progressive vision loss, it is characterized by the disruption of cells in a small area near the center of the retina, the macula."} +{"_id": "2945", "text": "An acromesomelic dysplasia that has_material_basis_in mutation in NPR-B receptor which results_in severe dwarfism, abnormalities of the located_in vertebral column and shortening of middle and distal segments in the located_in limb."} +{"_id": "2948", "text": "A viral infectious disease that involves fever and bleeding disorder caused by Arenavirus."} +{"_id": "2951", "text": "A genetic disease that has_material_basis_in mutations in the MODY genes disrupting insulin production."} +{"_id": "2954", "text": "A hypersensitivity reaction type II disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin)."} +{"_id": "2957", "text": "An autosomal dominant disease that is characterized by ankylosis of the proximal interphalangeal joints, carpal and tarsal bone fusion, and conductive deafness."} +{"_id": "2960", "text": "An autosomal dominant disease characterized by myxomas, spotty pigmentation of the skin and endocrine overactivity."} +{"_id": "2963", "text": "A focal dystonia that affects a single muscle or small group of muscles in the hand resulting from involuntary muscular contractions."} +{"_id": "2966", "text": "A giant cell tumor and bone cancer and bone tissue neoplasm that results_in the presence of multinucleated giant cells (osteoclast-like cell)."} +{"_id": "2969", "text": "An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem."} +{"_id": "2972", "text": "An autosomal dominant cerebellar ataxia that is characterized by slow degeneration of the hindbrain and has_material_basis_in expansion of CAG triplet repeats (glutamine) in the ATXN3 gene."} +{"_id": "2975", "text": "A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching."} +{"_id": "2978", "text": "Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions."} +{"_id": "2981", "text": "A laryngitis which lasts less than a few days."} +{"_id": "2984", "text": "A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon."} +{"_id": "2987", "text": "A pathologic nystagmus, present at birth, characterized by involuntary, rhythmic eye movements; oscillations are usually horizontal in direction."} +{"_id": "2990", "text": "A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. Peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. The symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output."} +{"_id": "2993", "text": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."} +{"_id": "2996", "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in vagina, has_material_basis_in human papillomavirus (type16), which cause malignant tumors in squamous epithelium of the vagina."} +{"_id": "2999", "text": "A sensory organ benign neoplasm that is located in the eye conjunctiva."} +{"_id": "3002", "text": "A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues."} +{"_id": "3005", "text": "A lipoma that is a painful subcutaneous nodule, having all other features of a typical lipoma."} +{"_id": "3008", "text": "A uterine disease that is located_in the placenta."} +{"_id": "3011", "text": "A ptosis characterized by eyelid drop present at birth."} +{"_id": "3014", "text": "A vitamin metabolic disorder that results from low blood levels of vitamin B12."} +{"_id": "3017", "text": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles."} +{"_id": "3020", "text": "A lipid metabolism disorder that has_material_basis_in X-linked inheritance of the tafazzin gene and is characterized by decreased production of an enzyme required to produce cardiolipin."} +{"_id": "3023", "text": "A hyperostosis that involves formation of new bone on the surface of preexisting bone."} +{"_id": "3026", "text": "An osteochondrosis that results_in death and collapse located_in navicular bone of foot."} +{"_id": "3029", "text": "An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress."} +{"_id": "3032", "text": "A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy."} +{"_id": "3035", "text": "A tinea capitis that results_in fungal infection located_in hair, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which produce arthroconidia within the hair shaft only."} +{"_id": "3038", "text": "A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy."} +{"_id": "3041", "text": "An upper respiratory tract disease which involves inflammation of the epiglottis due to infection. Haemophilus influenzae type B is the most common bacterial causative agent, although some cases are attributable to Streptococcus pneumoniae or Streptococcus pyogenes. The infection can cause the epiglottis to either obstruct or completely close off the windpipe. Epiglottitis typically affects children, and is associated with fever, difficulty in swallowing, drooling, hoarseness of voice, and stridor."} +{"_id": "3044", "text": "A neurodegenerative disease that is characterized by progressive cerebellar ataxia, leading to clumsiness in body movements, veering from midline when walking, wide-based stance, and falls without signs of paralysis or weakness and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in degeneration of neuron in the cerebellum, pons and inferior olives."} +{"_id": "3047", "text": "A viral infectious disease that results_in infection, has_material_basis_in Lujo virus, which has_symptom bleeding."} +{"_id": "3050", "text": "An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities."} +{"_id": "3053", "text": "A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year."} +{"_id": "3056", "text": "A syndrome characterized by intellectual disability, specific facial gestalt and Hirschsprung's disease (HSCR). It is caused by homozygous mutation in the KIAA1279 gene on chromosome 10q21.1."} +{"_id": "3059", "text": "A congenital hemolytic anemia characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood."} +{"_id": "3062", "text": "An age related macular degeneration that is characterized by progressive vision loss usually to the point of legal blindness."} +{"_id": "3065", "text": "An adenocarcinoma that results in a hard structure owing to the formation of dense connective tissue in the stroma."} +{"_id": "3068", "text": "An angiosarcoma and sarcoma of prostate that is located_in the prostate."} +{"_id": "3071", "text": "A muscular dystrophy that has_material_basis_in X-linked disease caused by mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy."} +{"_id": "3074", "text": "A papillary adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures with psammoma bodies."} +{"_id": "3077", "text": "A combined T cell and B cell immunodeficiency that is a rare autosomal recessive metabolic disorder caused by a mutaion in the PNP gene and characterized mainly by decreased T-cell function."} +{"_id": "3080", "text": "A viral infectious disease that results_in infection located_in mouth, has_material_basis_in human papillomavirus (types 13 or 32), has_symptom papules or nodules in the oral cavity."} +{"_id": "3083", "text": "A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture."} +{"_id": "3086", "text": "A heavy chain disease that results from an overproduction of mu antibody (IgM)."} +{"_id": "3089", "text": "An organ system cancer located_in the nervous sytem that affects the central or peripheral nervous system."} +{"_id": "3092", "text": "A spinal muscular dystrophy that has_material_basis_in an X-linked recessive expansion of CAG triplet repeats (glutamine)\\nin exon 1 of AR gene encoding the androgen receptor."} +{"_id": "3095", "text": "A Polyomaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Polyomavirus, which cause respiratory symptoms, cystitis or skin cancer."} +{"_id": "3098", "text": "A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary and testis."} +{"_id": "3101", "text": "A primary systemic mycosis that results_in systemic fungal infection through hematogenous spread, has_material_basis_in Sporothrix schenckii, a dimorphic fungus."} +{"_id": "3104", "text": "A hypersensitivity reaction type II disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva."} +{"_id": "3107", "text": "A uterine benign neoplasm derived from the smooth muscle layer of the uterus."} +{"_id": "3110", "text": "A tricuspid valve disease that is a congenital heart defect in which the septal leaflet of the tricuspid valve is displaced towards the apex of the right ventricle of the heart."} +{"_id": "3113", "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth."} +{"_id": "3116", "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood."} +{"_id": "3119", "text": "A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid \\cap\\\" cells of the arachnoid villi in the meninges.\""} +{"_id": "3122", "text": "An impulse control disorder that involves the uncontrollable plucking of ones hair."} +{"_id": "3125", "text": "An intestinal infectious disease that involves infection of the intestine by nosocomial bacterium Enterobacter aerogenes, which results in formation of ulcers."} +{"_id": "3128", "text": "A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages."} +{"_id": "3131", "text": "An eye and adnexa disease that is located in the vitreous of the eye."} +{"_id": "3134", "text": "An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood."} +{"_id": "3137", "text": "A movement disease characterized by brief, semi-directed, irregular movements that not repetitive or rhythmic, but appear to flow from one muscle to the next."} +{"_id": "3140", "text": "A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen."} +{"_id": "3143", "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract."} +{"_id": "3146", "text": "An agnosia that is a loss of the ability to acknowledge objects in the neglected field that are visible when a mirror reflects the object visible in the non-neglected field."} +{"_id": "3149", "text": "A kyphosis that results_in abnormal formation located_in body of vertebra."} +{"_id": "3152", "text": "A labyrinthitits in which bacterial toxins invade the inner ear. It is the most common complication of acute or chronic middle ear infections."} +{"_id": "3155", "text": "A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy."} +{"_id": "3158", "text": "A metal metabolism disorder characterized by the accumulation of iron in various organs of the body."} +{"_id": "3161", "text": "A Cytomegalovirus infectious disease that results_in inflammation, located_in brain, has_material_basis_in Human herpesvirus 5, has_symptom confusional syndrome, has_symptom seizures, has_symptom coma, has_symptom dysphasia, and has_symptom cranial nerve palsies."} +{"_id": "3164", "text": "A parotid disease characterized by the inflammation of one or both parotid glands."} +{"_id": "3167", "text": "A bone marrow cancer that affects plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body."} +{"_id": "3170", "text": "A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs."} +{"_id": "3173", "text": "A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure."} +{"_id": "3176", "text": "A sensory system disease that is located_in the eye or the adnexa of the eye."} +{"_id": "3179", "text": "A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip."} +{"_id": "3182", "text": "An organ system benign neoplasm located_in the axilla, an area directly under the arm and shoulder joint composed_of adipose tissue."} +{"_id": "3185", "text": "A sinusitis which involves infection of the frontal sinuses over the eyes in the brow area. This causes pain or pressure in the frontal sinus cavity and headache over the forehead."} +{"_id": "3188", "text": "A carcinoma of bladder that originates in the epithelial cells (the internal lining) of the bladder wall and is limited to this area."} +{"_id": "3191", "text": "An autosomal recessive disease characterized by oculocutaneous albinism, immune deficiency, coagulation deficiency and neuropathy; it is caused by mutations in the CHS1 gene."} +{"_id": "3194", "text": "A syndrome characterized by the presence of multiple enchondromas (benign growths of cartilage) associated with multiple hemangiomas."} +{"_id": "3197", "text": "A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work."} +{"_id": "3200", "text": "A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles."} +{"_id": "3203", "text": "A disease that has_material_basis_in genetic variations in the human genome."} +{"_id": "3206", "text": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."} +{"_id": "3209", "text": "An inflammatory bowel disease characterized by inflammation located_in ileum, has_symptom diarrhea, has_symptom abdominal pain, often in the right lower quadrant, has_symptom weight loss."} +{"_id": "3212", "text": "A malaria that is caused by the protozoan parasite Plasmodium vivax, which induces paroxysms at 48-hour intervals."} +{"_id": "3215", "text": "An adenovirus infectious disease that involves damage of the cells in the lining of the stomach and intestines caused by adenoviruses (types 40 and 41). The symptoms include watery diarrhea, vomiting and fever."} +{"_id": "3218", "text": "A retinoblastoma that has spread from the soft tissues surrounding the eye or to the optic nerve beyond the margin of resection to other parts of the body."} +{"_id": "3221", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Banna virus, which is transmitted_by Culex, and transmitted_by Anopheles mosquitoes. The infection has_symptom fever, and has_symptom headache."} +{"_id": "3224", "text": "An oropharyngeal candidiasis that involves fungal infection of the oropharynx by Candida species in AIDS patients."} +{"_id": "3227", "text": "A blood platelet disease characterized by low a platelet count in the blood."} +{"_id": "3230", "text": "A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces."} +{"_id": "3233", "text": "A cell type benign neoplasm that is composed_of glandular and fibrous tissues, with a relatively large proportion of glands."} +{"_id": "3236", "text": "A food allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms."} +{"_id": "3239", "text": "A pseudomembranous conjunctivitis characterized by swollen and reddened, hot and painful lids. The Corynebacterium diphtheriae bacilli produce profuse exudation which has a tendency to coagulate on the surface of the conjunctiva to form a grayish-white membrane."} +{"_id": "3242", "text": "A pneumonia that is an acute inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. It is a sentinel health event (occupational) associated with exposure to ammonia (refrigeration, fertilizer, and oil refining industries), chlorine (alkali and bleach industries), nitrogen oxides (silo fillers, arc welders, and nitric acid industry), sulfur dioxide (paper, refrigeration, and oil refining industries), cadmium (processors and cadmium smelters), trimellitic anhydride (plastics and organic chemical synthesis), and vanadium pentoxide (boilermakers). The two types of pulmonary agents are central and peripheral. Central pulmonary agents, for example, ammonia, are water soluble irritants that injure the upper airways. Peripheral pulmonary agents, for example, phosgene, NOx, and PFIB, are slightly water soluble irritants that injure the alveolar-capillary membranes. Chlorine has both central and peripheral effects."} +{"_id": "3245", "text": "An Escherichia coli intestinal infectious disease that involves infection of the intestine caused by a serological subgroup of Escherichia coli called enteroinvasive Escherichia coli (EIEC), which penetrate and multiply within epithelial cells of the colon causing cell destruction. They do not produce toxins but they possess a specific adhesin, which is an outer membrane protein. The symptoms include dysentery-like diarrhea with fever."} +{"_id": "3248", "text": "An aspergillosis that involves fungal infection of the central nervous system in immunocompromised patients caused by Aspergillus, presenting as a space-occupying lesion."} +{"_id": "3251", "text": "An aplastic anemia where the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes)."} +{"_id": "3254", "text": "A syndrome that is an adverse physical reaction to low levels of many common chemicals."} +{"_id": "3257", "text": "A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy."} +{"_id": "3260", "text": "A substance abuse that involves the recurring use of antidepressant drugs despite negative consequences."} +{"_id": "3263", "text": "A parasitic infectious disease that involves parasitic infection by the members of the class Ichthyosporea, which are parasites of fish and other animals."} +{"_id": "3266", "text": "A larynx sarcoma that is a smooth muscle connective tissue tymor located_in the larynx."} +{"_id": "3269", "text": "A retinal disease characterized by the slower than usual adaptation of the eyes to changing light conditions; can be caused by mutations in the RGS9 or the R9AP genes."} +{"_id": "3272", "text": "A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis."} +{"_id": "3275", "text": "An acrofacial dysostosis characterized by a spectrum of mandibulofacial dysostosis phenotypes, such as cleft palate, micrognathia, malar flattening, microcephaly and, in some cases, extrafacial skeletal defects. It is caused by heterozygous mutation in the POLR1A gene located in chromosome 2p11."} +{"_id": "3278", "text": "A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid."} +{"_id": "3281", "text": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions."} +{"_id": "3284", "text": "A crustacean allergy triggered by Scylla paramamosain."} +{"_id": "3287", "text": "A milk allergy triggered by Capra hircus milk."} +{"_id": "3290", "text": "A Mumps virus infectious disease that results_in inflammation located_in peripheral nerves, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom pins-and-needles sensation, has_symptom weakness, and has_symptom numbness."} +{"_id": "3293", "text": "A Simplexvirus infectious disease that results_in inflammation located_in iris and located_in ciliary body of the eye, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, and has_symptom redness, has_symptom photophobia, has_symptom lacrimation, and has_symptom blurred vision."} +{"_id": "3296", "text": "A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night."} +{"_id": "3299", "text": "A disease of mental health that involves disruption of sleep patterns."} +{"_id": "3302", "text": "A severe combined immunodeficiency an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3gamma chain precursors. Patients with CD3gamma deficiency have a severe defect in the expression of the T-cell receptor CD3-complex. Affected patients have decreased T-cell numbers and function; B cells are variably affected."} +{"_id": "3305", "text": "A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia ) or myeloid cells (acute myelocytic leukemia ) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia."} +{"_id": "3308", "text": "An organ system cancer located_in the genitourinary system that is characterized by uncontrolled cellular proliferation in reproductive and urinary organs."} +{"_id": "3311", "text": "An autoimmune disease of skin and connective tissue characterized by large blisters."} +{"_id": "3314", "text": "A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision."} +{"_id": "3317", "text": "A nonparalytic poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, which is transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms."} +{"_id": "3320", "text": "A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel."} +{"_id": "3323", "text": "A scoliosis with no known cause."} +{"_id": "3326", "text": "An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland."} +{"_id": "3329", "text": "A mixed germ cell cancer that is located_in areas of the body other than the ovary or testicle."} +{"_id": "3332", "text": "An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis."} +{"_id": "3335", "text": "A physical disorder characterized by a defect in the development of the abdominal wall muscles, resulting in the intestines, liver and other organs to remain outside of the abdomen in a sac."} +{"_id": "3338", "text": "An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism."} +{"_id": "3341", "text": "A chondrosarcoma that is located_in bone."} +{"_id": "3344", "text": "A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities."} +{"_id": "3347", "text": "A brain cancer that is usually located in the brain, but can occur anywhere in the central nervous system."} +{"_id": "3350", "text": "A syndrome characterized by a unique combination of cardiac arrhythmias and intestinal pseudo-obstruction; caused by the mutated SGOL1 protein. Distinctive clinical features include atrial dysrhythmias, sick sinus syndrome (SSS) and valve anomalies and chronic intestinal pseudo-obstruction (CIPO)."} +{"_id": "3353", "text": "A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached."} +{"_id": "3356", "text": "A syndrome characterized by limb defects, usually bilateral, like cleft hands or feet and longitudinal defects involving radius or ulna, tibia or fibula and renal anomalies which include agenesis, hypoplasia and rarely polycystic kidneys. Additional malformations may involve the oro-mandibular region, the trachea and lungs, skin derivatives including sweat glands, mammary glands, the uterus, vas deferens, the nasal placodes and the eyes."} +{"_id": "3359", "text": "A kidney cancer that is found in the kidney and is usually found before birth by ultrasound or within the first 3 months of life."} +{"_id": "3362", "text": "A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page."} +{"_id": "3365", "text": "A respiratory syncytial virus infectious disease that results_in inflammation located_in lung, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The disease is characterized by occasional multinucleated syncytial giant cells, hyperplasia of alveolar epithelial cells, epithelial necrosis of bronchioles and bronchi, papillary epithelial hyperplasia, and an inflammatory infiltrate composed of lymphocytes and macrophages in the peribronchial space and interstitium."} +{"_id": "3368", "text": "A toxoplasmosis that involves a reactivated infection of the mother transmitted to the fetus during pregnancy. Spontaneous abortion and stillbirth may occur."} +{"_id": "3371", "text": "A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability."} +{"_id": "3374", "text": "A lymphedema commonly located_in legs, caused_by congenital abnormalities in the lymphatic system."} +{"_id": "3377", "text": "A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from spindle cells and/or derives_from giant cells."} +{"_id": "3380", "text": "A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes."} +{"_id": "3383", "text": "A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains."} +{"_id": "3386", "text": "An agnosia that is a loss of the ability to recognize text."} +{"_id": "3389", "text": "A type of ALS with juvenile onset caused_by mutation located_in MATR3 gene located_in chromosome 5."} +{"_id": "3392", "text": "A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body."} +{"_id": "3395", "text": "An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting."} +{"_id": "3398", "text": "A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and results_in_formation_of nodules."} +{"_id": "3401", "text": "A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy."} +{"_id": "3404", "text": "An opportunistic mycosis that results_in disseminated infection, has_material_basis_in Trichosporon and results_in_formation_of nontender erythematous nodules anywhere on the body."} +{"_id": "3407", "text": "A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood."} +{"_id": "3410", "text": "A pigmentation disease characterized by a reticulate pattern of abnormally dark skin coloring, particularly in the body's folds and creases."} +{"_id": "3413", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia."} +{"_id": "3416", "text": "A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium."} +{"_id": "3419", "text": "A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus."} +{"_id": "3422", "text": "A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause."} +{"_id": "3425", "text": "A suppurative otitis media which is an inflammatory disease of the middle ear cleft characterized by the presence of a persisting perforation within the pars tensa of the tympanic membrane, intermittent profuse muco-purulent otorrhea and gradually progressive conductive hearing loss of more than 12 weeks duration. It is caused by episodes of upper respiratory infections."} +{"_id": "3428", "text": "An ectothrix infectious disease that results_in zoophilic inflammatory fungal infection located_in skin, located_in beard, located_in scalp and located_in nail in cattle and humans, has-agent Trichophyton verrucosum."} +{"_id": "3431", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Influenza A virus or has_material_basis_in Influenza B virus, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. The infection has_symptom fever, has_symptom reduced consciousness, and has_symptom ocular muscle palsies."} +{"_id": "3434", "text": "A peripheral neuropathy characterized by congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages."} +{"_id": "3437", "text": "A cancer that affects an anatomical entity."} +{"_id": "3440", "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Picornaviridae viruses."} +{"_id": "3443", "text": "A vascular disease that is located_in an artery."} +{"_id": "3446", "text": "An acute porphyria characterized by painful, blistering skin lesions that develop on sun-exposed skin."} +{"_id": "3449", "text": "A dysgerminoma of ovary that occurs in children."} +{"_id": "3452", "text": "A viral infectious disease that results_in infection located_in skin and located_in mucous membrane of cattle, has_material_basis_in Lumpy skin disease virus, which results_in_formation_of nodules on the skin particularly on the head, neck, udder, genitalia, perineum and legs, has_symptom fever, and has_symptom lymphadenopathy."} +{"_id": "3455", "text": "A Cytomegalovirus infectious disease that results_in infection located_in esophagus, has_material_basis_in Human herpesvirus 5 and has_symptom odynophagia, has_symptom nausea and vomiting, has_symptom fever, has_symptom diarrhea, and has_symptom hemoptysis."} +{"_id": "3458", "text": "A commensal bacterial infectious disease involving Klebsiella pneumoniae infection. Patients with Klebsiella pneumonia tend to cough up a characteristic sputum that is said to resemble \\red-currant jelly\\\". Klebsiella pneumonia tends to affect people with underlying diseases, such as alcoholism, diabetes and chronic lung disease. The symptoms include high fever, rigors and pleuritic pain, and hemoptysis.\""} +{"_id": "3461", "text": "A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus Leishmania, which is transmitted by the bite of sand fly (subfamily Phlebotominae)."} +{"_id": "3464", "text": "A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information."} +{"_id": "3467", "text": "A malaria that involves infection with more than one species of Plasmodium at the same time."} +{"_id": "3470", "text": "An eye disease where one or both eyeballs are abnormally small."} +{"_id": "3473", "text": "An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells."} +{"_id": "3476", "text": "A lysosomal storage disease that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase)."} +{"_id": "3479", "text": "A retinal vascular disease characterized by the prevention of blood vessel formation at the edges of the retina and the hemorrhage of the blood vessels in the retina."} +{"_id": "3482", "text": "A soft tissue cancer that is a soft tissue sarcoma and originates in the pericytes in the walls of capillaries."} +{"_id": "3485", "text": "A staphylococcal infectious disease that is caused by ingestion of food containing enterotoxins, which are produced by staphylococcal species. The symptoms include abdominal cramps, diarrhea, headache and fever."} +{"_id": "3488", "text": "An X-linked disease that is characterized by intellectual disability, truncal obesity, seizures, hypogonadism, developmental delay, distinctive facial features, tapered fingers and short toes and has_material_basis_in X-linked recessive inheritance of mutations in the PHF6 gene."} +{"_id": "3491", "text": "A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right)."} +{"_id": "3494", "text": "A tertiary syphilis that is characterized by granulomatous lesions, called gummas, which are characterized by a center of necrotic tissue with a rubbery texture. They form in the liver, bones, and testes but may affect any organ."} +{"_id": "3497", "text": "A late yaws that involves destruction of the bone and cartilage of the nose. This is caused by the spirochete bacterium, Treponema pallidum pertenue."} +{"_id": "3500", "text": "A viral infectious disease that results_in infection, has_material_basis_in Dengue virus with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding."} +{"_id": "3503", "text": "A cognitive disorder that involves an excessive, irrational dread of everyday situations."} +{"_id": "3506", "text": "A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening."} +{"_id": "3509", "text": "A viral infectious disease that results_in infection in cattle and other ruminants, has_material_basis_in Macavirus and has_symptom fever, has_symptom bilateral corneal opacity, and has_symptom oculonasal discharge."} +{"_id": "3512", "text": "An opportunistic mycosis that results_in fungal infection located_in lungs, has_material_basis_in Mucorales molds and has_symptom hemoptysis and has_symptom necrosis."} +{"_id": "3515", "text": "A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder."} +{"_id": "3518", "text": "A histiocytic and dendritic cell cancer that effect dendritic cells."} +{"_id": "3521", "text": "A staphylococcal infectious disease that is caused due to the infection by Gram-positive bacterium Staphylococcus aureus, which is an important cause of hospital-acquired infection that results in the formation of abscesses, empyema, pneumothorax, and cyst."} +{"_id": "3524", "text": "A carcinoma that is in situ (very early-stage breast cancer)."} +{"_id": "3527", "text": "A coxsackie carditis that results_in inflammation located_in myocardium, has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom lethargy, has_symptom heart failure, has_symptom pallor, has_symptom cyanosis, has_symptom dyspnea, has_symptom tachycardia, and has_symptom enlargement of heart."} +{"_id": "3530", "text": "A bacterial infectious disease that results_in infection by bacteria in individuals whose host defense mechanisms have been compromised."} +{"_id": "3533", "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system."} +{"_id": "3536", "text": "A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma."} +{"_id": "3539", "text": "A meningioma by site and orbital neoplasm that is located_in the area around the eye sockets of the skull and results_in pressure in the eyes, giving a bulging appearance."} +{"_id": "3542", "text": "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss."} +{"_id": "3545", "text": "An inherited blood coagulation disease characterized by the tendency to form clots in the veins."} +{"_id": "3548", "text": "An oral cavity cancer that has_material_basis_in squamous cells."} +{"_id": "3551", "text": "An opportunistic mycosis that results_in fungal infection located_in human body, has_material_basis_in Microsporidia phylum members."} +{"_id": "3554", "text": "A syndrome affecting returning military veterans and civilian workers of the Gulf War."} +{"_id": "3557", "text": "A hypersensitivity reaction type II disease that involves inflammation or pain in the muscles, joints, or fibrous tissue."} +{"_id": "3560", "text": "An amino acid metabolic disorder that has_material_basis in deficiency of ornithine translocase resulting in the accumulation of ammonia in the blood."} +{"_id": "3563", "text": "An Escherichia coli intestinal infectious disease that involves infection of the intestine caused by a serological subgroup of Escherichia coli called enterohemorrhagic Escherichia coli (EHEC), which cause hemorrhagic colitis or bloody diarrhea that can progress to hemolytic uremic syndrome. EHEC are considered to be moderately invasive and are characterized by the production of verotoxin or Shiga toxins. The infection results in copious bloody discharge."} +{"_id": "3566", "text": "A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss."} +{"_id": "3569", "text": "An exostosis that results_in an abnormal growth located_in calcaneus."} +{"_id": "3572", "text": "A respiratory syncytial virus infectious disease that results_in inflammation located_in bronchiole, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. Infection is characterized by inflammation, edema, and necrosis of the small airway epithelium with associated bronchospasm and increased mucous production."} +{"_id": "3575", "text": "A carcinoma that derives_from neuroendocrine cells."} +{"_id": "3578", "text": "An autosomal recessive disease that is caused by rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging."} +{"_id": "3581", "text": "A gastrointestinal system cancer that has_material_basis_in neuroendocrine cells."} +{"_id": "3584", "text": "An aortic aneurysm that is located_in the thoracic aorta."} +{"_id": "3587", "text": "An osteochondrodysplasia characterized by short limbs and a short trunk with a barrel-shaped chest and caused_by homozygous or compound heterozygous mutation in the DYM gene on chromosome 18q."} +{"_id": "3590", "text": "An anal carcinoma that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the anal margin (where the canal meets the outside skin at the anus)."} +{"_id": "3593", "text": "A transitional cell carcinoma that has several papillary fronds with central fibrovascular core lined by transitional type epithelium."} +{"_id": "3596", "text": "A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by viruses. The symptoms include abdominal pain, indigestion, ulcer formation, abdominal bloating, nausea and vomiting."} +{"_id": "3599", "text": "An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism."} +{"_id": "3602", "text": "A monogenic disease that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth)."} +{"_id": "3605", "text": "A colorectal cancer that is located_in the colon."} +{"_id": "3608", "text": "A pulmonary tuberculosis presenting as multiple bilateral large nodules in the lungs."} +{"_id": "3611", "text": "A RNA virus infectious disease that results_in infection, has_material_basis_in ssRNA retro-transcribing viruses, which possess single-stranded RNA genomes and replicate using reverse transcriptase."} +{"_id": "3614", "text": "A Mumps virus infectious disease that results_in inflammation located_in testis, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom groin pain, has_symptom discharge from penis, has_symptom scrotal swelling, and has_symptom blood in the semen."} +{"_id": "3617", "text": "An Alveolata infectious disease that involves infection caused by the members of the phylum Apicomplexa, which are unicellular, spore forming parasites of animals and humans."} +{"_id": "3620", "text": "A gastrointestinal system disease that is located_in the mouth."} +{"_id": "3623", "text": "A vitamin B12 deficiency that is characterized by megaloblastic anemia due to the absence of gastric intrinsic factor which results in abnormal vitamin B12 absorption."} +{"_id": "3626", "text": "A syndrome characterized by facial abnormalities such as telecanthus, epicanthus, broad flattened nose, large inverted W-shaped mouth and malformed ears, malformed extremities such as camptodactyly, clinodactyly, interdigital webbing and joint hyperlaxity and mental retardation."} +{"_id": "3629", "text": "A neonatal period electroclinical syndrome that is characterized by tonic-clonic seizures in newborns occurring within the first seven days of life and ceasing within the first 15 weeks of life and has_material_basis_in autosomal dominant inheritance of voltage-gated potassium channels or a chromosomal inversion."} +{"_id": "3632", "text": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle."} +{"_id": "3635", "text": "A fish allergy triggered by Cyprinus carpio."} +{"_id": "3638", "text": "A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow."} +{"_id": "3641", "text": "A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin."} +{"_id": "3644", "text": "An electroclinical syndrome with onset in the neonatal period less than 44 weeks of gestational age."} +{"_id": "3647", "text": "A parotid gland cancer that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ."} +{"_id": "3650", "text": "Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents."} +{"_id": "3653", "text": "A pneumoconiosis caused by inhalation and retention of asbestos fibers."} +{"_id": "3656", "text": "A viral gastritis that involves inflammation of the stomach lining caused by herpes simplex virus."} +{"_id": "3659", "text": "An agnosia that is a loss of the ability to gain feedback about one's own condition or impairments."} +{"_id": "3662", "text": "A syndrome mainly characterized by severe growth retardation and microcephaly. It is a new form of cohesinopathy showing defects in sister chromatid cohesion and hypersensitivity to chemicals that induce replication stress, thus combining distinct cytogenetic features seen in Roberts syndrome and Fanconi anemia, respectively. It is caused by homozygous or compound heterozygous mutation in the DDX11 gene on chromosome 12p11."} +{"_id": "3665", "text": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis."} +{"_id": "3668", "text": "An intestinal disease characterized by a dysbalance of the bacterial flora of the small intestine, causing derangement to the normal physiological processes of digestion and absorption."} +{"_id": "3671", "text": "A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms."} +{"_id": "3674", "text": "A bipolar disorder that is characterized by at least one manic or mixed episode."} +{"_id": "3677", "text": "An opportunistic mycosis that is located_in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has_symptom nonproductive cough, has_symptom shortness of breath, and has_symptom fever."} +{"_id": "3680", "text": "An idiopathic interstitial pneumonia that occurs mainly in women, people who do not smoke, and people younger than 50 years with no known cause or risk factors. Lung biopsies may show predominantly interstitial inflammation or fibrosis or a combination of inflammation and fibrosis. A dry cough and shortness of breath develop over 6 to 18 months. Low-grade fever and a feeling of illness (malaise) may occur."} +{"_id": "3683", "text": "A microsporidiosis that is a zoonotic infectious disease results_in disseminated fungal infection in dogs, cats, hamsters, guinea pigs, rats, mice and humans, has_material_basis_in Encephalitozoon cuniculi, has_material_basis_in Encephalitozoon intestinalis or has_material_basis_in Encephalitozoon hellem."} +{"_id": "3686", "text": "A parasitic helminthiasis infectious disease that involves infection caused by parasitic invertebrates, which have a pseudocoel. Tissue derived from mesoderm only partly lines the fluid filled body cavity of these animals."} +{"_id": "3689", "text": "An adenoma and biliary tract cancer that results_in a small firm white nodule with multiple bile ducts that are located_in a fibrous stroma."} +{"_id": "3692", "text": "A anus cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the anus."} +{"_id": "3695", "text": "A non-small cell lung carcinoma that has_material_basis_in the squamous cell."} +{"_id": "3698", "text": "A myotonic disease that is characterized by myotonia and progressive, proximal muscle wasting and weakness affecting the skeletal and smooth muscles of the neck, shoulders, elbows and hips and has_physical_basis_in the autosomal dominant inheritance of the CNBP (ZNF9) gene containing an expansion of a CCTG repeat in intron one."} +{"_id": "3701", "text": "An extrapulmonary tuberculosis that is located_in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction."} +{"_id": "3704", "text": "An opportunistic mycosis that is located_in lungs caused by inhalation of fungal spores while stripping the bark from maple logs, has_material_basis_in Cryptostroma corticale."} +{"_id": "3707", "text": "A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton mentagrophytes and results_in_formation_of subcutaneous abscesses."} +{"_id": "3710", "text": "An opportunistic mycosis that has_material_basis_in Scopulariopsis, which results_in a systemic infection in immunocompromised individuals."} +{"_id": "3713", "text": "Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection."} +{"_id": "3716", "text": "An appendix cancer that has_material_basis_in neurodendocrine cells."} +{"_id": "3719", "text": "A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella."} +{"_id": "3722", "text": "A parasitic protozoa infectious disease that has_symptommild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease."} +{"_id": "3725", "text": "A neutropenia characterized by a maturation arrest of granulopoiesis at the level or promyelocytes and early onset of severe bacterial infections."} +{"_id": "3728", "text": "A glioblastoma multiforme that is characterized by IDH1 and p53 mutations and Platelet Derived Growth Factor A amplification."} +{"_id": "3731", "text": "An autosomal recessive disease characterized by severe intellectual disability, epilepsy, scoliosis, choreoathetosis, dysmorphic facial features and altered dermal pigmentation."} +{"_id": "3734", "text": "An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system."} +{"_id": "3737", "text": "An amino acid metabolic disorder that involves impaired break down of the amino acid tyrosine."} +{"_id": "3740", "text": "A disease of anatomical entity that occurs in the muscular and/or skeletal system."} +{"_id": "3743", "text": "A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood."} +{"_id": "3746", "text": "A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing."} +{"_id": "3749", "text": "A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage."} +{"_id": "3752", "text": "A bronchus cancer that has_material_basis_in epithelial cells."} +{"_id": "3755", "text": "An autosomal recessive disease that is characterized by brachydactyly, hyperphalangism of digits, facial dysmorphism, dental anomalies, sensorineural hearing loss, delayed motor and mental development, and growth retardation and has_material_basis_in homozygous mutation in the CHSY1 gene."} +{"_id": "3758", "text": "A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels."} +{"_id": "3761", "text": "A vaginal carcinosarcoma derives_from the glands that line the uterus."} +{"_id": "3764", "text": "A metaphyseal dysplasia that results_in short-limbed dwarfism and fine sparse hair."} +{"_id": "3767", "text": "A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin."} +{"_id": "3770", "text": "A laryngitis in which symptoms last longer than three weeks. Gastroesophageal reflux, and lingering bronchitis can cause the disease."} +{"_id": "3773", "text": "An autosomal recessive disease characterized by mulitple fetal developmental defects including polydactyly and central nervous system malformations that results from a single amino acid mutation of D211G of the HYLS1 gene which plays a central role in cilia formation."} +{"_id": "3776", "text": "A fungal infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Fungi, which penetrate the dermis or even deeper during or after a skin trauma."} +{"_id": "3779", "text": "A palmoplantar keratosis characterized by keratoses with a \\raindrop\\\" pattern on the palmoplantar surface, skin lesions which may involve the whole of the palmoplantar surface, or may be more restricted in their distribution.\""} +{"_id": "3782", "text": "A Mononegavirales infectious disease that results_in infection in animals and humans, has_material_basis_in Rhabdoviridae viruses."} +{"_id": "3785", "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body."} +{"_id": "3788", "text": "A respiratory system cancer that is located_in the paranasal sinuses."} +{"_id": "3791", "text": "A placenta disease that is characterized by separation of the placental lining from the uterus of the mother."} +{"_id": "3794", "text": "An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type."} +{"_id": "3797", "text": "A desmoplastic small round-cell tumor that primarily is located_in the abdomen."} +{"_id": "3800", "text": "A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance."} +{"_id": "3803", "text": "A thyroid gland disease that involves an over production of thyroid hormone."} +{"_id": "3806", "text": "An urogenital tuberculosis that is located_in epididymis, has_symptom pain and has_symptom scrotal swelling."} +{"_id": "3809", "text": "A physical disorder characterized by pancreatic fibrosis, renal dysplasia and hepatic dysgenesis; it is usual fatal soon after birth."} +{"_id": "3812", "text": "A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted_by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins."} +{"_id": "3815", "text": "A thymic carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "3818", "text": "A vascular disease that is characterized by inflammation of the blood vessels."} +{"_id": "3821", "text": "An organ system benign neoplasm that is located_in the serous membrane lining the abdominal cavity or coelom."} +{"_id": "3824", "text": "An ophthalmic herpes zoster that results_in inflammation located_in iris and located_in ciliary body, has_material_basis_in Human herpesvirus 3,which reactivates from the trigeminal ganglion after the primary infection and has_symptom photophobia, has_symptom redness, has_symptom lacrimation, and blurres vision."} +{"_id": "3827", "text": "An autosomal dominant disease that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas."} +{"_id": "3830", "text": "An Enterovirus infectious disease that results_in infection, has_material_basis_in Swine vesicular disease virus, which is transmitted_by ingestion of contaminated food, or transmitted_by contact with an infected animal. The infection results_in_formation_of vesicles in the mouth, snout and feet, and has_symptom lameness."} +{"_id": "3833", "text": "A muscular dystrophy that chiefly affects muscles used for movement (skeletal) and heart (cardiac) muscle."} +{"_id": "3836", "text": "A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac."} +{"_id": "3839", "text": "A sarcoma and malignant neoplasm of anus that is located_in the anus."} +{"_id": "3842", "text": "A severe combined immunodeficiency that is an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3epsilon chain precursors. Patients with CD3epsilon deficiency have a severe defect in the expression of the T-cell receptor CD3-complex."} +{"_id": "3845", "text": "An agnosia that is a loss of the ability to recognising spoken words as semantically meaningful."} +{"_id": "3848", "text": "An acquired metabolic disease that is characterized by abnormal mineral metabolism."} +{"_id": "3851", "text": "A mood disorder that involves alternating periods of mania and depression."} +{"_id": "3854", "text": "A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs."} +{"_id": "3857", "text": "A diphtheria that involves membrane formation from the faucial tonsil areas over the pharyngeal wall and into the nasopharynx. Severe disease may cause marked edema of the submandibular areas and the anterior neck along with lymphadenopathy, giving a characteristic \\bullneck\\\" apprearance.\""} +{"_id": "3860", "text": "A acute serous otitis media caused by an allergen."} +{"_id": "3863", "text": "A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis."} +{"_id": "3866", "text": "A viral infectious disease that results_in infection in cattle, dogs, horses, pigs, and humans, has_material_basis_in Adenoviridae viruses."} +{"_id": "3869", "text": "A tricuspid valve disease that is characterized by the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve."} +{"_id": "3872", "text": "A lacrimal gland carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "3875", "text": "A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired."} +{"_id": "3878", "text": "A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair."} +{"_id": "3881", "text": "A carcinoma that derives_from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm."} +{"_id": "3884", "text": "A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough."} +{"_id": "3887", "text": "A squamous cell carcinoma that has papillae, which are characterized either by narrow fibrovascular cores that superficially resemble papillary carcinoma of the urinary tract or by broad cores that contain edematous fibrous stroma with prominent capillaries and stromal inflammation."} +{"_id": "3890", "text": "A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions."} +{"_id": "3893", "text": "A hyperostosis characterized by excessive bone formation most prominent in the skull, mandible, clavicle, ribs and diaphyses of long bones; bone formation occurs throughout life."} +{"_id": "3896", "text": "A syndrome that is characterized by blepharophimosis, ptosis, dental hypoplasia, hearing impairment and intellectual disability."} +{"_id": "3899", "text": "A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath."} +{"_id": "3902", "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain."} +{"_id": "3905", "text": "A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands."} +{"_id": "3908", "text": "A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy."} +{"_id": "3911", "text": "A serine deficiency that has_material_basis_in deficiency of phosphoserine aminotransferase and is characterized by low concentartions of serine and flycine in plasma and cerebrospinal fluid."} +{"_id": "3914", "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme iduronate sulfatase."} +{"_id": "3917", "text": "A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia."} +{"_id": "3920", "text": "A stomach disease that is an inflammation of the lining of the stomach."} +{"_id": "3923", "text": "A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing."} +{"_id": "3926", "text": "An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue."} +{"_id": "3929", "text": "A severe combined immunodeficiency that is an actin regulator when mutated results in SCID through inhibition of thymic egress of mature thymocytes into peripheral lymphoid organs."} +{"_id": "3932", "text": "A viral infectious disease that results_in infection located_in brain, has_material_basis_in Measles virus which is immune resistant (which can be a result of a mutation of the virus itself)."} +{"_id": "3935", "text": "A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage."} +{"_id": "3938", "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, with villous architecture."} +{"_id": "3941", "text": "A lymph node disease characterized by enlarged, non-painful lymph nodes occurring for more than three to six months for which no other reason can be found."} +{"_id": "3944", "text": "An acrocephalosyndactylia characterized by craniosynostosis, acrocephaly, obesity, syndactyly and polydactyly."} +{"_id": "3947", "text": "An opportunistic fungi incertae sedis mycosis that results_in fungal infection located_in sinuses, located_in brain, or located_in lungs of immunocompromised people, has_material_basis_in Mucorales molds."} +{"_id": "3950", "text": "A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language."} +{"_id": "3953", "text": "A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis."} +{"_id": "3956", "text": "A tertiary syphilis that results_in infection located_in brain or located_in spinal cord."} +{"_id": "3959", "text": "A musculoskeletal system cancer that is located_in muscle."} +{"_id": "3962", "text": "A muscular dystrophy that is characterized by progressive muscle wasting and weakness."} +{"_id": "3965", "text": "A uterine corpus cancer that has_material_basis_in more than one type of cell."} +{"_id": "3968", "text": "A pleural cancer that has_material_basis_in mesothelium cells."} +{"_id": "3971", "text": "A uterine cancer that is located_in tissues lining the uterus."} +{"_id": "3974", "text": "An autosomal recessive disease characterized by dwarfism, facial dysmorphia and skeletal abnormalities."} +{"_id": "3977", "text": "A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart."} +{"_id": "3980", "text": "A serine deficiency that has_material_basis_in deficiency of phosphoserine phosphatase impeding the synthesis of L-serine."} +{"_id": "3983", "text": "A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction."} +{"_id": "3986", "text": "A thyroid sarcoma and angiosarcoma that results_in a high prevalence of iodine-deficient goiter."} +{"_id": "3989", "text": "An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body."} +{"_id": "3992", "text": "An autosomal dominant disease that is characterized by the iris stroma being hypoplastic resulting from abnormalities in the differentiation of the anterior segment structures and increased values of intraocular pressure and has_material_basis_in autosomal dominant inheritance of mutations in the PITX2 gene."} +{"_id": "3995", "text": "A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis."} +{"_id": "3998", "text": "A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved."} +{"_id": "4001", "text": "A lung cancer that derives_from the distal bronchioles or alveoli that initially exhibit a specific non-invasive growth pattern."} +{"_id": "4004", "text": "A dystonia that involves two or more unrelated body parts."} +{"_id": "4007", "text": "A otosalpingitis which is persistent and long-lasting."} +{"_id": "4010", "text": "A substance abuse that involves the recurring use of opioid drugs despite negative consequences."} +{"_id": "4013", "text": "A syndrome characterized by intellectual disability and developmental delay, breathing problems, recurrent seizures (epilepsy), and distinctive facial features. It is caused by heterozygous de novo mutations in the TCF4 gene in chromosome 18q21."} +{"_id": "4016", "text": "A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern."} +{"_id": "4019", "text": "A parasitic protozoa infectious disease that involves infection caused by parabasalids, which are anaerobic flagellated protozoans."} +{"_id": "4022", "text": "A selective immunoglobulin deficiency disease that is caused by a reduction in some types of gamma globulins."} +{"_id": "4025", "text": "An intestinal benign neoplasm that has_material_basis_in epithelial tissue with glandular origin and is located_in the rectum."} +{"_id": "4028", "text": "A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption."} +{"_id": "4031", "text": "A malignant neoplasm of ovary and nephroblastoma that is located_in the ovaries."} +{"_id": "4034", "text": "A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components."} +{"_id": "4037", "text": "A bone benign neoplasm that is located_in the phalanx that has_material_basis_in cartilaginous cells."} +{"_id": "4040", "text": "A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids."} +{"_id": "4043", "text": "An adult sarcoma of soft tissue that derives_form the soft tissues of the body."} +{"_id": "4046", "text": "A otosalpingitis with a sudden onset and a short course."} +{"_id": "4049", "text": "A purine-pyrimidine metabolic disorder that is an autosomal recessive metabolic disorder in which there is absent or significantly decreased activity of dihydropyrimidine dehydrogenase, an enzyme involved in the metabolism of uracil and thymine."} +{"_id": "4052", "text": "An agnosia that results in the loss of the ability to consciously recognize familiar faces."} +{"_id": "4055", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa."} +{"_id": "4058", "text": "A somatoform disorder that involves heart disease symptoms without any identifiable physiological abnormatlities."} +{"_id": "4061", "text": "A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness."} +{"_id": "4064", "text": "A dysostosis characterized by intellectual disability, short stature, hypertelorism, broad notched nasal tip, cleft lip palate, postaxial camptobrachypolysyndactyly, fibular hypoplasia and anomalies of foot structure."} +{"_id": "4067", "text": "A Charcot-Marie-Tooth disease characterized by demyelination of the peripheral nerve axons."} +{"_id": "4070", "text": "A biliary tract neoplasm that has_material_basis_in epithelial tissue of glandular origin located_in the gallbladder."} +{"_id": "4073", "text": "A non-syndromic intellectual disability characterized by an autosomal recessive inheritance pattern."} +{"_id": "4076", "text": "A dsRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Reoviridae viruses."} +{"_id": "4079", "text": "A monogenic disease that is characterized by hypertelorism, hypospadias, and additional midline defects resulting from mutations to the MID1 gene in the X-linked form or from a deletion on chromosome 22q11.2 in the autosomal dominant form."} +{"_id": "4082", "text": "A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength."} +{"_id": "4085", "text": "A cryptococcosis that is_a disease associated with AIDS has_material_basis_in Cryptococcus neoformans which results_in a systemic infection in individuals with HIV."} +{"_id": "4088", "text": "A ciliopathy that causes a defect in the action of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube."} +{"_id": "4091", "text": "A nervous system disease that results_from damage located_in left parietal lobe, has_symptom agraphia, has_symptom acalculia, has_symptom finger agnosia."} +{"_id": "4094", "text": "A salivary gland cancer that has_material_basis_in epithelial cells."} +{"_id": "4097", "text": "A taeniasis that results from ingestion of eggs or larvae of the Taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. Neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions."} +{"_id": "4100", "text": "An ophthalmic herpes zoster that results_in inflammation located_in cornea and located_in conjunctiva, has_material_basis_in Human herpesvirus 3, which reactivates from the trigeminal ganglion after the primary infection and has_symptom red eye, has_symptom irritation, and has_symptom pain."} +{"_id": "4103", "text": "A lysosomal storage disease that has_material_basis_in deficiency of the alpha-D-manosidase enzyme resulting in the impairment of cell function from a build up of complex sugars derived from glycoproteins in the lysosome."} +{"_id": "4106", "text": "A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years."} +{"_id": "4109", "text": "A blepharoconjunctivitis that is characterized by fissuring, scaling, maceration and erythema of the lateral or medial canthal area."} +{"_id": "4112", "text": "An aortic valve disease that has_physical_basis_in incomplete opening of the aortic valve."} +{"_id": "4115", "text": "A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids."} +{"_id": "4118", "text": "A spinal cancer that is located_in the spinal cord and derives_from lymphocytes."} +{"_id": "4121", "text": "An adrenal medulla cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "4124", "text": "A nervous system disease that is located_in nerves or nerve cells."} +{"_id": "4127", "text": "An Apicomplexa infectious disease that involves infection caused by the members of the class Aconoidasida."} +{"_id": "4130", "text": "A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles."} +{"_id": "4133", "text": "A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness."} +{"_id": "4136", "text": "An appendix carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "4139", "text": "An organ system benign neoplasm that is located_in reproductive system organs."} +{"_id": "4142", "text": "An osteochondrodysplasia that results_in short arms and legs with excess folds of skin."} +{"_id": "4145", "text": "A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization."} +{"_id": "4148", "text": "A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "4151", "text": "A corneal dystrophy that is characterized by corneal haze, bilateral loss of vision, eventually necessitating corneal transplantation resulting from progressive punctate opacities in the cornea."} +{"_id": "4154", "text": "An Enterovirus infectious disease that results_in infection located_in gastrointestinal tract, or located_in skin, has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by droplet spread of oronasal secretions from infected person, or transmitted_by contaminated fomites."} +{"_id": "4157", "text": "A fallopian tube cancer that is characterized as a mixture of carcinoma and sarcoma and has_material_basis_in epithelial tissue and has_material_basis_in connective tissue."} +{"_id": "4160", "text": "An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently and characterized by an enlarged heart."} +{"_id": "4163", "text": "An osteosclerosis that results_in coarsening located_in trabecular bone."} +{"_id": "4166", "text": "A genetic disease that is characterized by permanently bent fingers (camptodactyly), short stature, rocker-bottom or club feet, joints that are bent in a fixed position (contractures), union or webbing of the skin between the fingers (syndactyly), and/or webbing of the neck, inside bend of the elbows, back of the knees and armpits."} +{"_id": "4169", "text": "A bile duct carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "4172", "text": "A multiple carboxylase deficiency that involves a deficiency in biotinidase."} +{"_id": "4175", "text": "A shellfish allergy triggered by Crustacea."} +{"_id": "4178", "text": "An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function."} +{"_id": "4181", "text": "An embryonal cancer that are masses of rapidly growing cells that originates in embryonic (fetal) tissue in the brain and spinal cord."} +{"_id": "4184", "text": "A syndrome characterized by unusually sparse, brittle, curly hair, macrocephaly, a prominent forehead and bi-temporal narrowing, intellectual disability, failure to thrive, congenital heart defects, short stature and skin abnormalities; it is caused by mutation in the BRAF, MAP2K1, MAP2kK2 and KRAS genes."} +{"_id": "4187", "text": "A viral infectious disease that results_in infection in fish, has_material_basis_in Viral hemorrhagic septicemia virus, which is transmitted_by contact with the contaminated water, or transmitted_by direct contact. The infection has_symptom hemorrhages in the internal organs, skin, and muscle, has_symptom bulging eyes, and has_symptom bloated abdomens."} +{"_id": "4190", "text": "A Varicellovirus infectious disease that results_in infection located_in skin of eyelid, has_material_basis_in Human herpesvirus 3 and has_symptom rash after the reactivation of latent virus years after the primary infection."} +{"_id": "4193", "text": "A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs."} +{"_id": "4196", "text": "A dystonia that affects most or all of the body."} +{"_id": "4199", "text": "A pharynx cancer that has_material_basis_in squamous cells."} +{"_id": "4202", "text": "A mucopolysaccharidosis characterized by corneal clouding, facial dysmorphism and normal lifespan."} +{"_id": "4205", "text": "A Simplexvirus infectious disease that results_in inflammation located_in liver, has-agent Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, and has_symptom fever, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, and has_symptom herpetic lesions."} +{"_id": "4208", "text": "A severe combined immunodeficiency that affects the development and function of T cells."} +{"_id": "4211", "text": "A primary Bacillaceae infectious disease involving Bacillus anthracis infection resulting in pulmonary infiltrates and necrosis."} +{"_id": "4214", "text": "A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign."} +{"_id": "4217", "text": "A syndrome that is characterized by large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues."} +{"_id": "4220", "text": "A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver."} +{"_id": "4223", "text": "A mitochondrial metabolism disease that is characterized by hearing loss that begins early in life, problems with movement, impaired vision, and behavior problems."} +{"_id": "4226", "text": "A type of ALS were intermediate-length polyglutamine repeat expansions in the ATXN2 gene located_in chromosome 12 contribute to susceptibility."} +{"_id": "4229", "text": "A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations."} +{"_id": "4232", "text": "A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies."} +{"_id": "4235", "text": "An osteosclerosis that results_in increased calcium concentration located_in skull which decreases the size of cranium foramina and cervical spinal canal."} +{"_id": "4238", "text": "A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp."} +{"_id": "4241", "text": "A food allergy triggered by Crustacea or Mollusca."} +{"_id": "4244", "text": "A middle ear carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "4247", "text": "A carbohydrate metabolic disorder that involves a defect in galactose metabolism resulting in toxic levels of galactose 1-phosphate in various tissues."} +{"_id": "4250", "text": "A parasitic infectious disease that involves infection caused by parasitic members of the taxon stramenopiles, in which the flagellate cells possess two different shaped flagella. This taxon contains both unicellular and multicellular organisms."} +{"_id": "4253", "text": "An acquired metabolic disease that has_material_basis_in low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate."} +{"_id": "4256", "text": "A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures."} +{"_id": "4259", "text": "An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by a translocation between chromosomes 15 and 17."} +{"_id": "4262", "text": "A blood platelet disease characterized by thrombocytopathy, thrombocytopenia, mild anemia, asplenia, tubular aggregate myopathy, miosis, headache, and ichthyosis. It is caused by heterozygous in the STM1 gene located in chromosome 11p15. It has an autosomal dominant inheritance pattern."} +{"_id": "4265", "text": "A syndrome characterized by a combination of multiple joint contractures and osteogenesis imperfecta."} +{"_id": "4268", "text": "An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb Dwarfism."} +{"_id": "4271", "text": "A cerebellum cancer that begins in the lower part of the brain on the floor of the skull."} +{"_id": "4274", "text": "An inherited metabolic disorder that involves plasma protein metabolism malfunction."} +{"_id": "4277", "text": "An immune system disease that has_material_basis_in hematopoietic cells."} +{"_id": "4280", "text": "An autosomal recessive disease characterized by severe intellectual disability, microcephaly, congenital cataract, microcornea, microphthalmia, agenesis or hypoplasia of the corpus callosum and hypogenitalism."} +{"_id": "4283", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Dicrocoelium dendriticum. The symptoms include cholecystitis, liver abscesses and upper abdominal pain."} +{"_id": "4286", "text": "A parasitic protozoa infectious disease that involves an infection in humans and animals caused by a parasitic protozoan of genus Acanthamoeba, which is an opportunistic pathogen occuring in patients with weakened immune system."} +{"_id": "4289", "text": "A Yellow fever virus infectious disease that results_in inflammation located_in liver, has_material_basis_in Yellow fever virus. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom weakness, has_symptom nausea, has_symptom vomiting, has_symptom jaundice, and has_symptom hemorrhagic manifestations."} +{"_id": "4292", "text": "A parasitic helminthiasis infectious disease that involves infection of the small intestine in humans, cats, dogs and foxes by the nematode Uncinaria stenocephala. The symptoms include diarrhea and hypoproteinemia in heavier infections."} +{"_id": "4295", "text": "An Apicomplexa infectious disease that involves infection caused by the members of the class Coccidia, which are spore-forming, single-celled and obligate intracellular parasites of the intestinal tract of animals and humans."} +{"_id": "4298", "text": "An amyotrophic lateral sclerosis caused_by mutation located_in TUBA4A gene located_in chromosome 2q35."} +{"_id": "4301", "text": "A non-Hodgkin's lymphoma that is caused by a mutation of T cells."} +{"_id": "4304", "text": "A specific phobia that involves a fear caused by the presence or thought of a specific animal that poses little or no danger at all."} +{"_id": "4307", "text": "A breast carcinoma that is located_in the nipple."} +{"_id": "4310", "text": "An organ system benign neoplasm that is located_in the muscular and skeletal organs."} +{"_id": "4313", "text": "An amino acid metabolic disorder that is an autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid causing progressive brain damage."} +{"_id": "4316", "text": "A dermatomycosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi which are not dermatophytes and has_symptom opaque nail, has_symptom yellow-brown nail, has_symptom crumbly nail that can separate from the nail bed."} +{"_id": "4319", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis."} +{"_id": "4322", "text": "A cell type benign neoplasm that has_material_basis_in glial-type cells."} +{"_id": "4325", "text": "A spondyloepimetaphyseal dysplasia that is characterized by spondylar and nasal changes, with striations of the metaphyses that has_material_basis_in autosomal recessive inheritance."} +{"_id": "4328", "text": "A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite (\\comfort eating\\\"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.\""} +{"_id": "4331", "text": "A primary systemic mycosis that results_in fungal infection located_in lungs, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom lung lesions, has_symptom pleural thickening and results_in_formation_of pulmonary nodules."} +{"_id": "4334", "text": "An adenovirus infectious disease that involves inflammation of the liver caused by Human adenovirus 1, has_material_basis_in Human adenovirus 2, or has_material_basis_in Human adenovirus 5. The symptoms include fever, coagulopathy and gastrointestinal bleeding. Histopathological examination reveals widespread hepatic necrosis with hemorrhage."} +{"_id": "4337", "text": "An ovarian carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "4340", "text": "A basal ganglia disease characterized by the presence of abnormal calcium deposits of unknown cause in the brain; has symptom dementia, psychosis, mood swings and loss of acquired motor skills."} +{"_id": "4343", "text": "A cervical carcinosarcoma is located_in the cervix with morphological features resembling Wilms tumor of the kidney."} +{"_id": "4346", "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Tahyna virus, which is transmitted_by Aedes, transmitted_by Culex, and transmitted_by Ochlerotatus mosquitoes. The infection has_symptom headache, has_symptom fever, has_symptom anorexia, and has_symptom seizures."} +{"_id": "4349", "text": "A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting."} +{"_id": "4352", "text": "An African histoplasmosis that results_in inflammation located_in meninges, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and results_in_formation_of focal mass lesions, has_symptom headache, has_symptom confusion, has_symptom decreased level of consciousness, has_symptom cranial nerve deficits, and has_symptom seizures."} +{"_id": "4355", "text": "A pharynx cancer that is located_in the hypopharynx."} +{"_id": "4358", "text": "A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect."} +{"_id": "4361", "text": "A cell type benign neoplasm that has_material_basis in mesothelium."} +{"_id": "4364", "text": "A drug dependence that is a psychological dependency on the regular use of cocaine."} +{"_id": "4367", "text": "A goiter characterized by a multinodular enlargement of the thyroid gland."} +{"_id": "4370", "text": "A peritoneum cancer that develops from cells of the mesothelium and is located_in the peritoneum."} +{"_id": "4373", "text": "A malaria characterized as a vector-borne infectious disease of birds caused by protozoan parasites Plasmodium relictum, Plasmodium anasum or Plasmodium gallinaceum, which are transmitted by Culex quinquefasciatus mosquitoes, causing anemia."} +{"_id": "4376", "text": "A movement disease characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain."} +{"_id": "4379", "text": "A spastic cerebral palsy that affects one side of the body resulting in stiff arm, hand and leg. On the affected side,the arm and leg may not develop normally."} +{"_id": "4382", "text": "A Parkinson's disease caused by heterozygous mutation in the gene encoding dardarin , LRRK2, located on chromosome 12q12."} +{"_id": "4385", "text": "A crustacean allergy triggered by Fenneropenaeus indicus."} +{"_id": "4388", "text": "An amebiasis that involves infection of the intestine with the protozoan parasite Entamoeba histolytica trophozoites resulting in intermittent nondysenteric diarrhea with abdominal pain, mucus, flatulence, and weight loss. Chronic infection manifests as tender, palpable masses or annular lesions (amebomas) in the cecum and ascending colon."} +{"_id": "4391", "text": "A fruit allergy triggered by Malus domestica plant fruit food product."} +{"_id": "4394", "text": "A toxoplasmosis that occurs in patients with AIDS or weakened immune system, who develop the infection due to reactivation, present with ring-enhancing intracranial mass lesions or encephalitis. The symptoms include headache, altered mental status, seizures, coma, fever, motor or sensory loss, cranial nerve palsies, visual abnormalities, and focal seizures."} +{"_id": "4397", "text": "A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain."} +{"_id": "4400", "text": "A mitochondrial metabolism disease characterized by a wide range of manifestations including marked and often fatal lactic acidosis, cardiomyopathy, leukoencephalopathy, pure myopathy and hepatopathy with tubulopathy. Among the numerous clinical phenotypes observed are Leigh syndrome, Leber hereditary optic neuropathy and MELAS syndrome. It can be caused by mutations in multiple different genes, both nuclear-encoded and mitochondrial-encoded."} +{"_id": "4403", "text": "A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host."} +{"_id": "4406", "text": "A viral infectious disease that involves necrosis of the liver caused by Canine adenovirus 1 in dogs, wolves, coyotes and bears. The symptoms include fever, leukopenia, apathy, anorexia, conjunctivitis, serous discharge from the eyes and nose, petechiae of the oral mucosa, subcutaneous edema of the head, neck and trunk, hematomas in the mouth, jaundice, and hepatic encephalopathy."} +{"_id": "4409", "text": "A vascular disease that is located_in the liver."} +{"_id": "4412", "text": "A nephritis that causes inflammation of the glomeruli located_in kidney."} +{"_id": "4415", "text": "A pre-eclampsia characterized by the presence of seizures."} +{"_id": "4418", "text": "An organ system benign neoplasm located_in the immune system organs."} +{"_id": "4421", "text": "A central nervous system lipoma that is characterized by abnormal fat accumulation in and around the spinal cord."} +{"_id": "4424", "text": "A neuropathy that affect the nerves that control the voluntary muscles."} +{"_id": "4427", "text": "A thoracic cancer that is located_in the chest wall."} +{"_id": "4430", "text": "A syphilis that is the first stage of syphilis, marked by the development of a chancre, which is characterized by mononuclear leukocytic infiltration, macrophages, and lymphocytes."} +{"_id": "4433", "text": "A Mumps virus infectious disease that results_in inflammation located_in pancreas, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom abdominal pain, has_symptom chills, has_symptom fever, and has_symptom persistent vomiting."} +{"_id": "4436", "text": "A malignant melanoma of iris and spindle cell intraocular melanoma that is located_in the iris."} +{"_id": "4439", "text": "A Paramyxoviridae infectious disease that results_in infection, has_material_basis_in Respirovirus, which is transmitted_by contact with the respiratory secretions of an infected person."} +{"_id": "4442", "text": "A color blindness that is characterized by a congenital cone color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels has_material_basis_in autosomal recessive inheritance."} +{"_id": "4445", "text": "A dsDNA-RT virus infectious disease that results_in infection in animals and humans, located_in liver, has_material_basis_in Hepadnaviridae viruses."} +{"_id": "4448", "text": "A severe combined immunodeficiency that is the result of a mutation on Chromosome 6 RAG1 gene involving genetic rearrangement of both the T- and B-lymphocyte receptor genes."} +{"_id": "4451", "text": "A bile duct carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "4454", "text": "A gastrointestinal system cancer that is located_in the stomach."} +{"_id": "4457", "text": "An autosomal recessive cerebellar ataxia that is characterized by congenital onset of nonprogressive cerebellar ataxia, disturbed equilibrium, and mental retardation, associated with cerebellar hypoplasia."} +{"_id": "4460", "text": "A toxoplasmosis that results from reactivation of congenital toxoplasmosis, but rarely with acquired infection. Focal necrotizing retinitis and a secondary granulomatous inflammation of the choroid occur. The symptoms include conjunctivitis, ocular pain, blurred vision, and blindness."} +{"_id": "4463", "text": "A lung cancer that is located_in the lung and that arises from transformed cells of mesenchymal origin."} +{"_id": "4466", "text": "A heavy chain disease that results from an overproduction of alpha antibodies (IgA)."} +{"_id": "4469", "text": "A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores."} +{"_id": "4472", "text": "An osteogenesis imperfecta characterized by craniosynostosis, communicating hydrocephalus, ocular proptosis, marked postnatal growth failure, and distinctive facial appearance."} +{"_id": "4475", "text": "An abdominal tuberculosis that results_in formation of granulomas or abscesses located_in spleen."} +{"_id": "4478", "text": "A trichostrongyloidiasis that involves infection of the small intestine with Trichostrongylus colubriformis or Trichostrongylus axei, which results in abdominal pain, diarrhea, anorexia, headache, fatigue, anemia and eosinophilia."} +{"_id": "4481", "text": "A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia."} +{"_id": "4484", "text": "A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years."} +{"_id": "4487", "text": "An urogenital tuberculosis that results_in formation of granulomas located_in kidney."} +{"_id": "4490", "text": "A bone cancer that has_material_basis in neural crest cells derived_from undeveloped, undifferentiated neuroectoderm."} +{"_id": "4493", "text": "A methylmalonic aciduria that is characterized by combined homocystinuria and methylmalonic aciduria and deficiency of MCM and MS activities."} +{"_id": "4496", "text": "A urinary system disease which consists of the presence of bacteria in urine."} +{"_id": "4499", "text": "A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults."} +{"_id": "4502", "text": "A bladder carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "4505", "text": "A schistosomiasis that is a short-term, cutaneous inflammatory response associated with penetration of the skin by cercariae of bird schistosome, Austrobilharzia variglandis. The disease has_symptom skin reddening, has_symptom skin itching, in the water or immediately after emerging and has_symptom itchy, raised papules, occur within hours of infection."} +{"_id": "4508", "text": "A glycogen storage disease characterized by enlargement of the liver, moderately low blood sugar, elevated levels of acetone and other ketone bodies in the blood and moderate growth retardation."} +{"_id": "4511", "text": "A opisthorchiasis that involves parasitic infection of the liver, biliary ducts, pancreas and pancreatic ducts by Opisthorchis viverrini. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma."} +{"_id": "4514", "text": "A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis."} +{"_id": "4517", "text": "An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs."} +{"_id": "4520", "text": "A tuberculosis that is a chronic and progressive wasting and weakness caused by infection of companion, captive exotic, wild and domestic birds with Mycobacterium avium complex (serotypes 1, 2 and 3) and M. genavense."} +{"_id": "4523", "text": "A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever."} +{"_id": "4526", "text": "A brain cancer that is located_in the supratentorial region."} +{"_id": "4529", "text": "An ampulla of Vater carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "4532", "text": "A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness."} +{"_id": "4535", "text": "A movement disease that is of unknown etiology characterized by progressive rigidity."} +{"_id": "4538", "text": "A parasitic protozoa infectious disease that involves infection of the cornea of the eye with Acanthamoeba in people wearing contact lenses. The symptoms include eye pain, eye redness, blurred vision, sensitivity to light, excessive tearing and sensation of something in the eye."} +{"_id": "4541", "text": "A cancer of urethra that has recurred after it has been treated. The cancer may come back in the urethra or in other parts of the body."} +{"_id": "4544", "text": "An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite."} +{"_id": "4547", "text": "A gastrointestinal system disease that is located_in the stomach."} +{"_id": "4550", "text": "A spondyloepiphyseal dysplasia characterized by short stature with hyperpigmented macules and an unusual facies, proteinuria with progressive renal failure, lymphopenia with recurrent infections, and cerebral ischaemia. It is caused by mutations in the SMARCAL1 gene."} +{"_id": "4553", "text": "A bone inflammation disease that results_in inflammation located_in epicondyle."} +{"_id": "4556", "text": "A superficial mycosis that results_in fungal infection of the outermost layer located_in skin and located_in hair shaft, has_material_basis_in Ascomycota phylum members."} +{"_id": "4559", "text": "A cryptococcosis that results_in inflammation located_in lungs, has_material_basis_in Cryptococcus neoformans which results_in_formation_of nodular lesions and results_in_formation_of lobar consolidation in the lungs of the immunocompetent patient and has_symptom cough, has_symptom chest pain and has_symptom difficulty breathing."} +{"_id": "4562", "text": "A Yersinia infectious disease that involves infection of the intestine caused by Yersinia enterocolitica. The symptoms include fever, abdominal pain, and diarrhea (often bloody in children)."} +{"_id": "4565", "text": "An ureter cancer that is located_in the ureter."} +{"_id": "4568", "text": "A hypotrichosis that is characterized by a loss of hair from the head or body."} +{"_id": "4571", "text": "An intellectual disability that is characterized by the absence of associated medical and behavioral signs and symptoms."} +{"_id": "4574", "text": "A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage."} +{"_id": "4577", "text": "A viral infectious disease that has_material_basis in Zika virus, which is transmitted_by Aedes aegypti mosquitoes."} +{"_id": "4580", "text": "A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity."} +{"_id": "4583", "text": "A fish allergy triggered by Danio rerio."} +{"_id": "4586", "text": "A colitis that can only be diagnosed_by the examination of colon tissue under a microscope."} +{"_id": "4589", "text": "A serine deficiency that has_material_basis_in deficiency of phosphoglycerate dehydrogenase which results in a disruption of L-serine biosynthesis."} +{"_id": "4592", "text": "An autosomal recessive disease caused by homozygous mutation the SNAP29 gene and characterized by a unique constellation of clinical manifestations including microcephaly, severe neurologic impairment, psychomotor retardation, failure to thrive, facial dysmoprhism, palmoplantar keratoderma and late-onset ichthyosis."} +{"_id": "4595", "text": "A gastrointestinal system cancer that is located_in the oral cavity."} +{"_id": "4598", "text": "A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin."} +{"_id": "4601", "text": "A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions."} +{"_id": "4604", "text": "A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus."} +{"_id": "4607", "text": "A skeletal muscle cancer that arise from skeletal muscle progenitors."} +{"_id": "4610", "text": "A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice."} +{"_id": "4613", "text": "A capillariasis that involves infection of the liver with Capillaria, which manifests as an acute or subacute hepatitis with eosinophilia. The symptoms include abdominal pain, fever, chills, hepatitis, ascites, hepatolithiasis, and hepatomegaly."} +{"_id": "4616", "text": "A syndrome characterized by polyhydramnios with neonatal macrosomia, nephromegaly, distinctive facial appearance, renal dysplasia, nephroblastomatosis, and predisposition to Wilms tumor. It shows similarities to Beckwith-Wiedemann syndrome."} +{"_id": "4619", "text": "A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host."} +{"_id": "4622", "text": "A disease that manifests in a defined anatomical structure."} +{"_id": "4625", "text": "A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule."} +{"_id": "4628", "text": "A pharynx cancer that is located_in the nasopharynx, the uppermost region of the pharynx or \\throat\\\", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.\""} +{"_id": "4631", "text": "An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males."} +{"_id": "4634", "text": "An amino acid metabolic disorder characterized by the body's inability to effectively break down lysine, arginine and ornithine and by renal hyperdiaminoaciduria, especially lysinuria, and by impaired formation of urea with hyperammonemia after protein ingestion. It is caused by homozygous or compound heterozygous mutation in the amino acid transporter gene SLC7A7 on chromosome 14q11."} +{"_id": "4637", "text": "A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells."} +{"_id": "4640", "text": "A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter."} +{"_id": "4643", "text": "A cancer of urethra that shows squamous cell differentiation."} +{"_id": "4646", "text": "A muscular dystrophy that is an autosomal recessive disorder present at birth, which may result in contractures, scoliosis, respiratory and swallowing difficulties, and foot deformities."} +{"_id": "4649", "text": "A syndrome characterized by distinctive facial features including hypertelorism, large eyelid openings, ptosis, high-arched eyebrows, a broad nasal bridge and tip of the nose, a long space between the nose and the upper lip, full cheeks and a pointed chin; structural abnormalities of the brain might also be present."} +{"_id": "4652", "text": "A lipid metabolism disorder that involves defects in steroid metabolism."} +{"_id": "4655", "text": "A type of ALS caused_by mutation located_in FUS gene located_in chromosome 16."} +{"_id": "4658", "text": "A parasitic helminthiasis infectious disease that has_material_basis_in Taenia solium or has_material_basis_in Taenia saginata, which are transmitted_by ingestion of undercooked contaminated meat."} +{"_id": "4661", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis."} +{"_id": "4664", "text": "A syndrome characterized by multiple congenital anomalies and mental retardation. Other characteristics include a peculiar facial gestalt, short stature, skeletal and visceral abnormalities, cardiac anomalies, and immunological defects."} +{"_id": "4667", "text": "A neuromuscular disease that is characterized by the disfunction of conduction through the neuromuscular junction."} +{"_id": "4670", "text": "A frontal sinusitis which lasts for 12 weeks or more. This causes steady headache, localized tenderness and intermittent, purulent nasal and postnasal drainage."} +{"_id": "4673", "text": "An anal canal cancer that derives_from epithelial cells."} +{"_id": "4676", "text": "An bone structure disease that involves degeneration between vertebra located_in vertebral column."} +{"_id": "4679", "text": "A otitis externa which is a microbial infection that occurs suddenly, rapidly worsens, and becomes very painful and alarming. It is caused by swimming in polluted water, scratching the ear or inside the ear and object stuck in the ear. It is occasionally associated with middle ear infection or upper respiratory infections such as colds."} +{"_id": "4682", "text": "A stromal sarcoma and sarcoma of prostate and tumor of specialized prostatic stroma that is located_in the prostate."} +{"_id": "4685", "text": "An inherited metabolic disorder that involves metabolic disturbances in the processing or distribution of dietary minerals."} +{"_id": "4688", "text": "A primary immunodeficiency disease that involves multiple components of the immune system, including both humoral immunity and cell-mediated immunity."} +{"_id": "4691", "text": "An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene."} +{"_id": "4694", "text": "A spotted fever that has_material_basis_in Rickettsia japonica, which is transmitted_by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has_symptom fever, has_symptom eschars, has_symptom regional adenopathy, and has_symptom rash on extremities."} +{"_id": "4697", "text": "A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks."} +{"_id": "4700", "text": "An Alphavirus infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, has_material_basis_in Venezuelan equine encephalitis virus, or has_material_basis_in Western equine encephalomyelitis virus, which are transmitted_by moquito bite. The infection has_symptom fever, has_symptom headache, and has_symptom malaise."} +{"_id": "4703", "text": "A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip."} +{"_id": "4706", "text": "A Rubella virus infectious disease that results_in inflammation located_in liver, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection results in hepatic necrosis."} +{"_id": "4709", "text": "A bone remodeling disease that has_material_basis_in \\nimpaired mineralization or calcification of bones before epiphyseal closure due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium which results_in softening and deformity located_in bone."} +{"_id": "4712", "text": "A central nervous system cancer that is located_in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer)."} +{"_id": "4715", "text": "An anogenital venereal wart that results_in infection located_in mucosa of vagina, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct sexual contact with the skin of an infected partner. The infection has_symptom vaginal warts."} +{"_id": "4718", "text": "An embryonal carcinoma that is located_in the testis."} +{"_id": "4721", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection."} +{"_id": "4724", "text": "A multifocal dystonia that involves the arm and leg on the same side of the body."} +{"_id": "4727", "text": "A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars."} +{"_id": "4730", "text": "A vaginal benign neoplasm that is characterized by the presence of a fibrovascular stalk lined by normal squamous epithelium."} +{"_id": "4733", "text": "A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever."} +{"_id": "4736", "text": "An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period."} +{"_id": "4739", "text": "A trypanosomiasis that involves inflammation of the meninges caused due to Trypanosoma species."} +{"_id": "4742", "text": "An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "4745", "text": "A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder."} +{"_id": "4748", "text": "A B-cell lymphoma that is characterized by initial formation in the marginal zones of lymph tissue."} +{"_id": "4751", "text": "An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma, arising from an anatomic site other than the liver."} +{"_id": "4754", "text": "An X-linked disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait."} +{"_id": "4757", "text": "A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue."} +{"_id": "4760", "text": "A colonic disease that is characterized by an abnormal dilation of the colon."} +{"_id": "4763", "text": "A teeth hard tissue disease characterized by presence of normal enamel but atypical dentin with abnormal pulpal morphology."} +{"_id": "4766", "text": "A Charcot-Marie-Tooth disease that is characterized optic atrophy followed by retinitis pigmentosa."} +{"_id": "4769", "text": "A uterine corpus cancer that is characterized histologically by papillae with fibrovascular cores, marked nuclear atypia, psammoma bodies and cilia."} +{"_id": "4772", "text": "A cell type benign neoplasm that is composed_of a mixture of gonadal elements."} +{"_id": "4775", "text": "A chordoma that histologically derives_from chordoma, derives_from chondroma, and derives_from chondrosarcoma."} +{"_id": "4778", "text": "A blue drum syndrome caused by an allergen."} +{"_id": "4781", "text": "An urogenital tuberculosis that results_in formation of granulomas located_in fallopian tube."} +{"_id": "4784", "text": "An ectothrix infectious disease that results_in zoophilic fungal infection located_in skin, and located_in hair, has_material_basis_in Microsporum distortum, which causes infections in cats, dogs and other animals."} +{"_id": "4787", "text": "A stomach cancer that is located_in the stomach."} +{"_id": "4790", "text": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart."} +{"_id": "4793", "text": "A tracheal disease characterized by flaccidity of the tracheal support cartilage."} +{"_id": "4796", "text": "A central nervous system disease that results_in the progressive deterioration of function or structure of neurons."} +{"_id": "4799", "text": "A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times."} +{"_id": "4802", "text": "A night blindness that is characterized by hemeralopia with a moderate loss of visual acuity and caused by defective photoreceptor-to-bipolar cell signaling with common ERG findings of reduced or absent b-waves and generally normal a-waves."} +{"_id": "4805", "text": "A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision."} +{"_id": "4808", "text": "A functioning pituitary adenoma that characterized by excess cortisol a primary cause of Cushing's syndrome."} +{"_id": "4811", "text": "A disease that is present at birth due to a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment."} +{"_id": "4814", "text": "A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing."} +{"_id": "4817", "text": "A syndrome that involves occipital head aches, nystagmus on head movement, tinnitus, spasms, blurred vision, corneal hyperaesthesia, and corneal ulcers."} +{"_id": "4820", "text": "A disease of anatomical entity that is located_in the gastrointestinal tract."} +{"_id": "4823", "text": "A viral infectious disease that results_in infection in mammals, has_material_basis_in Pestivirus, which is transmitted_by contact with nasal secretions of an infected animal. The infection has_symptom diarrhea, has_symptom respiratory problems, and has_symptom bleeding disorder."} +{"_id": "4826", "text": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from mesenchymal cells."} +{"_id": "4829", "text": "A viral infectious disease that results_in infection in birds, has_material_basis_in Avian leukosis virus, which causes wide range of tumors."} +{"_id": "4832", "text": "A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure."} +{"_id": "4835", "text": "A lipid metabolism disorder characterized by malnutrition, failure to thrive, growth failure, vitamin E deficiency and the absence of chylomicrons and apolipoprotein B48 post-prandially. It has an autosomal recessive inheritance pattern and is caused by mutations in the SAR1B gene located in chromosome 5q31.1."} +{"_id": "4838", "text": "A gastrointestinal system benign neoplasm located_in the hepatobiliary system."} +{"_id": "4841", "text": "A colorectal cancer that derives_from epithelial cells of glandular origin."} +{"_id": "4844", "text": "A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma."} +{"_id": "4847", "text": "An adenocarcinoma that derives_from epithelial cells which have clear cytoplasm."} +{"_id": "4850", "text": "An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate."} +{"_id": "4853", "text": "A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide."} +{"_id": "4856", "text": "A otitis externa which involves bacterial infections often related to underlying comorbidities as well as trauma. Common sources of trauma include ear piercing, boxing, blunt trauma, burns, bite wounds and iatrogenic insults. The common bacterial pathogens are staphylococcal and streptococcal species."} +{"_id": "4859", "text": "A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes."} +{"_id": "4862", "text": "An ocular cancer that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells and arises_from the tissues that cover structures located_in the eye."} +{"_id": "4865", "text": "A syndrome characterized by progressive weakness and atrophy of muscles in feet, legs and hands. In some patients the syndrome also causes decreased sensitivity to touch, heat or cold, particularly in the lower arms or legs."} +{"_id": "4868", "text": "A rectum sarcoma that is a smooth muscle tumor and is located_in the rectum."} +{"_id": "4871", "text": "A type of ALS caused_by mutation located_in VCP gene located_in chromosome 9."} +{"_id": "4874", "text": "A diphtheria that involves a bluish white membrane formation on the faucial pillars, uvula, soft palate and tonsils."} +{"_id": "4877", "text": "A syndactyly characterized by an increased number of digits; often a result of a mutation in the HOX D13 gene."} +{"_id": "4880", "text": "A candidiasis that involves fungal infection of the oropharynx in immunocompromised patients caused by Candida species resulting in formation of white plaques on the buccal mucosa, tongue, gums, palate, or pharynx. The symptoms include burning or dryness of the mouth, loss of taste, and pain on swallowing."} +{"_id": "4883", "text": "A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells."} +{"_id": "4886", "text": "An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development."} +{"_id": "4889", "text": "An aortic aneurysm that is located_in the abdominal aorta."} +{"_id": "4892", "text": "A gender identity disorder that is characterized by having a sexual orientation or an attraction that is at odds with one's idealized self-image, causing anxiety and a desire to change one's orientation or become more comfortable with one's sexual orientation."} +{"_id": "4895", "text": "A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has_symptom soft-tissue swelling, has_symptom bone lesions, and has_symptom irritability."} +{"_id": "4898", "text": "An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue."} +{"_id": "4901", "text": "A lymphoblastic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood."} +{"_id": "4904", "text": "An autosomal dominant disease characterized by abnormal development of ectodermal tissues including the skin, hair, nails, teeth and sweat glands and anhidrotic ectodermal dysplasia with cleft lip/palate."} +{"_id": "4907", "text": "A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis."} +{"_id": "4910", "text": "A psychotic disorder that involves schizophrenia symptoms over time period of one month."} +{"_id": "4913", "text": "A bone structure disease that involves a defect located_in lumbar vertebral column."} +{"_id": "4916", "text": "A malignant giant cell tumor that is composed_of multinucleated giant cells."} +{"_id": "4919", "text": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis."} +{"_id": "4922", "text": "An amino acid metabolic disorder that involves an accumulation of homocysteine in the serum and an increased excretion of homocysteine in the urine."} +{"_id": "4925", "text": "An ischemic bone disease that results_in necrosis located_in bone."} +{"_id": "4928", "text": "A blepharitis that is characterized by an infection of the sebaceous glands of Zeis at the base of the eyelashes, or an infection of the apocrine sweat glands of Moll."} +{"_id": "4931", "text": "A commensal streptococcal infectious disease that is caused due to the infection by group A streptococci, of which Streptococcus pyogenes is the most important pathogen. The infection results in the development of empyema, pneumothorax, and cyst."} +{"_id": "4934", "text": "An uterine corpus cancer that is located_in the muscles of the uterus or located_in other tissues that support the uterus."} +{"_id": "4937", "text": "A opportunistic mycosis that results_in fungal infection located_in gastrointestinal tract, has_material_basis_in Mucorales molds in immunocompromised patients, results_in_formation_of intra-abdominal abscess and has_symptom abdominal pain, has_symptom distention, has_symptom nausea, and has_symptom vomiting."} +{"_id": "4940", "text": "A syndrome that is characterized by progressive proximal muscle weakness, steolytic bone lesions consistent with Paget disease, and frontotemporal dementia and has_physical_basis_in mutation in the valosin containing protein (VCP)."} +{"_id": "4943", "text": "A syndrome that is characterized by sensorineural hearing loss with onset in infancy, followed in adolescence by progressive optic nerve atrophy with loss of vision and in adulthood by progressive dementia."} +{"_id": "4946", "text": "A perichondritis of auricle which is persistent and long-lasting."} +{"_id": "4949", "text": "A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses."} +{"_id": "4952", "text": "A migraine that is characterized by migraine headaches that are not accompanied by an aura."} +{"_id": "4955", "text": "A Varicellovirus infectious disease that results_in infection located_in peripheral nervous system in swine, cattle, sheep, dogs and raccoons, has_material_basis_in Suid herpesvirus 1 and has_symptom abortion, has_symptom coughing, has_symptom sneezing, has_symptom fever, has_symptom constipation, has_symptom depression, has_symptom seizures, has_symptom ataxia, has_symptom circling, has_symptom excess salivation in piglets, and has_symptom intense itching in cattle."} +{"_id": "4958", "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye."} +{"_id": "4961", "text": "A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Treponema carateum, which is transmitted_by contact with skin and mucous membrane of an infected person. The infection has_symptom pruritic plaque, which slowly enlarges and becomes pigmented and hyperkeratotic."} +{"_id": "4964", "text": "A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes."} +{"_id": "4967", "text": "An agnosia that is a loss of the ability to recognize familiar voices."} +{"_id": "4970", "text": "A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood."} +{"_id": "4973", "text": "An autosomal recessive disease characterized by callosal agenesis, cataracts, cardiomyopathy, combined\\nimmunodeficiency and hypopigmentation. It is caused by mutation in the EPG5 gene located in chromosome 18q12.3."} +{"_id": "4976", "text": "A bone cancer that is located_in almost exclusively in the long bones."} +{"_id": "4979", "text": "A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising caused by a heritable defect in collagen synthesis, which leads to marked healing difficulties. EDS has five cardinal signs, which may be present to some degree in all of the subtypes. These five cardinal signs are skin fragility, blood vessel fragility, skin hyperelasticity, joint hypermobility, and characteristic subcutaneous nodules."} +{"_id": "4982", "text": "A brucellosis that involves an infection caused by Brucella abortus in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia."} +{"_id": "4985", "text": "A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs."} +{"_id": "4988", "text": "A cutaneous mycosis that results_in fungal infection located_in skin, located_in hair and located_in nail, has_material_basis_in Ascomycota phylum members."} +{"_id": "4991", "text": "An Enterovirus infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Human echovirus 11, which is transmitted_by contaminated drinking water. The infection has_symptom diarrhea."} +{"_id": "4994", "text": "An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract."} +{"_id": "4997", "text": "A candidiasis that involves fungal infection of the mucous membrane of the mouth by Candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes."} +{"_id": "5000", "text": "A female reproductive system disease that is located_in the uterus."} +{"_id": "5003", "text": "A childhood kidney neoplasm that is located_in the in the kidney as well as other locations outside the kidneys such as the liver, muscle, heart, lung, soft tissues, skin, the central nervous system."} +{"_id": "5006", "text": "An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building."} +{"_id": "5009", "text": "A sarcoma that results_in the formation of numerous sarcomas or located_in various parts of the body."} +{"_id": "5012", "text": "An eye disease characterized by nonsyphilitic interstitial keratitis located_in cornea, has_symptom fever, has_symptom fatigue."} +{"_id": "5015", "text": "A schistosomiasis that involves parasitic infection of domestic animals caused by a trematode fluke Schistosoma bovis."} +{"_id": "5018", "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase."} +{"_id": "5021", "text": "An Escherichia coli intestinal infectious disease that involves infection of the intestine caused by a serological subgroup of Escherichia coli called enterotoxigenic Escherichia coli (ETEC), which are non-invasive and produce heat-labile enterotoxin (LT) or heat stable toxin (ST). The bacteria colonize the GI tract by means of a fimbrial adhesin. The symptoms include diarrhea without fever."} +{"_id": "5024", "text": "An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones."} +{"_id": "5027", "text": "A respiratory system cancer that is located_in the trachea."} +{"_id": "5030", "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the urethra caused by Trichomonas vaginalis, which results in pain during urination."} +{"_id": "5033", "text": "A shellfish allergy triggered by Mollusca."} +{"_id": "5036", "text": "A filarial elephantiasis that involves parasitic infection of the lymphatic system by a filarial worm Wuchereria bancrofti, which is transmitted by mosquitoes. The symptoms include lymphedema, fever, chills, skin infections, painful lymph nodes, orchitis and epididymitis."} +{"_id": "5039", "text": "A syndrome characterized by craniofacial, neurologic, limb and ocular abnormalities."} +{"_id": "5042", "text": "A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm."} +{"_id": "5045", "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the foreskin and glans in uncircumcised males caused by Trichomonas vaginalis resulting in redness of foreskin or penis, rash on the head of penis, foul-smelling discharge, and painful penis and foreskin."} +{"_id": "5048", "text": "A pertussis that is a milder disease caused by the bacterium Bordetella parapertussis. The disease has_symptom coughing, has_symptom sneezing, or has_symptom runny nose ."} +{"_id": "5051", "text": "A cancer that is classified based on the organ it starts in."} +{"_id": "5054", "text": "A viral infectious disease that results_in_formation_of vesicles located_in epithelium of the snout, lips, nostrils, tongue, feet and mammary glands of swine, has_material_basis_in Vesicular exanthema of swine virus, which is transmitted_by direct contact."} +{"_id": "5057", "text": "A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function."} +{"_id": "5060", "text": "An echinococcosis that is caused by the larvae of Echinococcus vogeli or Echinococcus oligarthrus, which infect the liver."} +{"_id": "5063", "text": "A sarcoma of the mediastinum and synovial sarcoma that is located_in the mediastinum."} +{"_id": "5066", "text": "A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma."} +{"_id": "5069", "text": "A urinary system cancer that is located_in the ureter."} +{"_id": "5072", "text": "A parasitic ectoparasitic infectious disease that involves parasitic infestation by members of the subclass Hirudinea. The leeches remain attached to their hosts and feed on blood until they become full, at which point they fall off to digest. While feeding, they release an anesthetic and use a combination of mucus and suction to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream."} +{"_id": "5075", "text": "A bone cancer that is located_in bone that has_material_basis_in cells of mesenchymal origin."} +{"_id": "5078", "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Snowshoe hare virus, which is transmitted_by Aedes mosquitoes. The infection has_symptom headache, has_symptom fever, has_symptom anorexia, and has_symptom seizures."} +{"_id": "5081", "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Human torovirus, which is transmitted_by ingestion of food contaminated with feces. The infection has_symptom bloody diarrhea."} +{"_id": "5084", "text": "An autosomal dominant disease characterized by congenital anomalies located_in heart and located_in upper limb."} +{"_id": "5087", "text": "A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain."} +{"_id": "5090", "text": "A human papillomavirus related adenocarcinoma that results_in infection, located_in endocervix, has_material_basis_in human papillomaviruses (types 16, 18, 31, 39 or 45), which cause lesions that progress to cancers."} +{"_id": "5093", "text": "A pyrimidine metabolic disorder that is characterized by an excessive secretion of orotic acid in urine."} +{"_id": "5096", "text": "A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Pseudallescheria boydii, which results_in_formation_of abscesses."} +{"_id": "5099", "text": "An asthma that is a life threatening condition with progressive respiratory failure, which does not respond to standard treatment."} +{"_id": "5102", "text": "A keratosis characterized_by keratinizing squamous epithelium located_in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction."} +{"_id": "5105", "text": "An adult sarcoma of soft tissue and mesenchymal chondrosarcoma that is located_in the cartilage."} +{"_id": "5108", "text": "A viral infectious disease that results_in infection, has_material_basis_in Human herpesvirus 4, which is transmitted_by contact with the saliva."} +{"_id": "5111", "text": "A (-)ssRNA virus infectious disease that results_in infection in rodents and humans, has_material_basis_in Arenaviridae viruses."} +{"_id": "5114", "text": "A syndrome characterized by distinctive facial appearance, a cluster of minor and major anomalies and central nervous system dysfunction."} +{"_id": "5117", "text": "A parasitic protozoa infectious disease involving infection caused by Balantidium coli. The trophozoites are capable of attacking the intestinal epithelium, creating ulcers and causing bloody diarrhea. The infectiou has_symptom cramping, has_symptom abdominal pain, has_symptom nausea and has_symptom foul breath."} +{"_id": "5120", "text": "A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis."} +{"_id": "5123", "text": "A sarcoma that affects adults and is located_in the muscle, located_in fat, located_in fibrous tissue, located_in blood vessels, or located_in other supporting tissue of the body."} +{"_id": "5126", "text": "A ethmoid sinusitis which lasts for less than 4 weeks."} +{"_id": "5129", "text": "An acrocephalosyndactylia characterized by abnormalities in the bones of the legs, congenital heart defects and craniofacial defects and craniosynostosis. The patients suffer from cyanosis and other respiratory and breathing infections."} +{"_id": "5132", "text": "A rickets that has_material_basis_in increased serum 1,25-dihydroxyvitamin D levels and increased intestinal calcium absorption and is characterized by the presence of hypophosphatemia secondary to renal phosphate wasting, radiographic and/or histologic evidence of rickets, limb deformities, muscle weakness, and bone pain."} +{"_id": "5135", "text": "A vascular disease that is characterized as a small vascular malformation of the gut."} +{"_id": "5138", "text": "A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium."} +{"_id": "5141", "text": "A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others."} +{"_id": "5144", "text": "A lymphatic system disease that is characterized by inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. It is caused by Streptococcus pyogenes (Group A strep) or Staphylococcus aureus. Lymphangitis is also sometimes called blood poisoning."} +{"_id": "5147", "text": "A disorder that is a psychological or behavioral pattern associated with distress or disability that occurs in an individual and is not a part of normal development or culture."} +{"_id": "5150", "text": "A bone remodeling disease that results in an abnormal growth of located_in bone."} +{"_id": "5153", "text": "A hereditary ataxia that has_material_basis_in autosomal dominant inheritance."} +{"_id": "5156", "text": "A cell type benign neoplasm that has_material_basis_in odontogenic epithelium."} +{"_id": "5159", "text": "A sarcoma that results_in cells that are spindle-shaped. They are usually resistant to radiation therapy."} +{"_id": "5162", "text": "A sarcoma and malignant tumor of trachea that is located_in the trachea."} +{"_id": "5165", "text": "A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys."} +{"_id": "5168", "text": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "5171", "text": "A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight."} +{"_id": "5174", "text": "A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed."} +{"_id": "5177", "text": "A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face."} +{"_id": "5180", "text": "A syphilis that results_in a multisystem infection in the fetus via the placenta."} +{"_id": "5183", "text": "A thyroid gland disease that is characterized by excess thyroid hormone."} +{"_id": "5186", "text": "An acrocephalosyndactylia that has_material_basis_in mutations in the FGFR1 and FGFR2 gene which results_in premature fusion located_in skull."} +{"_id": "5189", "text": "A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms."} +{"_id": "5192", "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis."} +{"_id": "5195", "text": "A trichostrongyloidiasis that involves parasitic infection of the ruminant abomasum by nematodes of the genus Haemonchus resulting in anemia, dehydration, diarrhea and accumulation of fluid in the abdomen, gut wall, thoracic cavity and submandibular tissue."} +{"_id": "5198", "text": "A Simplexvirus infectious disease that results_in inflammation located_in cornea of the eye, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, and has_symptom photophobia, has_symptom blurred vision, has_symptom tearing, has_symptom pain, and has_symptom redness."} +{"_id": "5201", "text": "A substance abuse that involves the recurring use of hallucinogenic drugs despite negative consequences."} +{"_id": "5204", "text": "A spotted fever that has_material_basis_in Rickettsia conorii subsp caspia, which is transmitted_by ticks (Rhipicephalus pumilio and Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities."} +{"_id": "5207", "text": "A viral infectious disease that has_material_basis_in human papillomaviruses, which establish productive infections only in the stratified epithelium of the skin or mucous membranes. These viruses cause warts and sometimes tumors. They are transmitted_by sexual contact."} +{"_id": "5210", "text": "A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea."} +{"_id": "5213", "text": "A parasitic ectoparasitic infectious disease that involves parasitic infestation of blood feeding ticks of the families Ixodidae and Argasidae on animals and humans. Ticks are vectors of a number diseases, including Lyme disease, Q fever, Colorado tick fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis and tick-borne meningoencephalitis, as well as anaplasmosis in cattle and canine jaundice."} +{"_id": "5216", "text": "A Varicellovirus infectious disease that results_in inflammation located_in lung, has_material_basis_in Human herpesvirus 3, has_symptom rash, has_symptom tachypnea, has_symptom chest tightness, has_symptom cough, has_symptom dyspnea, has_symptom fever, has_symptom pleuretic chest pain, and has_symptom hemoptysis."} +{"_id": "5219", "text": "An anogenital venereal wart that results_in infection located_in skin of vulva, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct sexual contact with the skin of an infected partner. The infection has_symptom vulvar warts."} +{"_id": "5222", "text": "A skin malanoma that results_in nonpigmented lesions located_in sun-exposed areas of the body, most commonly on the head and neck."} +{"_id": "5225", "text": "A type of ALS caused_by mutation located_in TARDBP gene located_in chromosome 1."} +{"_id": "5228", "text": "An astrocytoma that is characterized as a low grade astrocytoma and has_material_basis_in neoplastic astrocytes."} +{"_id": "5231", "text": "An autosomal dominant disease characterized by abnormal development of the face, skin and genitals. Clinical expressions of the disease include cleft lip, with or without cleft palate, contractures of the lower extremities, abnormal external genitalia, syndactyly of fingers and/or toes, and a pyramidal skin fold over the hallux nail. It is caused by mutations in the IRF6 gene located in chromosome 1."} +{"_id": "5234", "text": "A myeloma that is located_in the plasma cells in bone marrow."} +{"_id": "5237", "text": "A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen."} +{"_id": "5240", "text": "A metaphyseal dysplasia that results_in dwarfism and bowed legs."} +{"_id": "5243", "text": "A hematopoietic system disease characterized by oval or elliptical red blood cells, slight or absent hemolysis with little or no anemia; splenomegaly is often present."} +{"_id": "5246", "text": "A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum."} +{"_id": "5249", "text": "A conjunctival disease characterized by an inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids."} +{"_id": "5252", "text": "An amino acid metabolic disorder that involves phenylalanine and tyrosine metabolism with the accumulation of homogentisic acid, a toxic tyrosine byproduct."} +{"_id": "5255", "text": "An 2-hydroxyglutaric aciduria that involves developmental delay, seizures, weak muscle tone (hypotonia), and abnormalities in the largest part of the brain (the cerebrum), which controls many important functions such as muscle movement, speech, vision, thinking, emotion, and memory."} +{"_id": "5258", "text": "An X-linked disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in X-linked inheritance and a loss of FMR1 function."} +{"_id": "5261", "text": "A learning disability involing difficulty reading resulting primarily from neurological factors which affect any part of the reading process."} +{"_id": "5264", "text": "A primary bacterial infectious disease that has_material_basis_in Francisella tularensis, which is transmitted_by dog tick bite (Dermacentor variabilis), transmitted_by deer flies (Chrysops sp) or transmitted_by contact with infected animal tissues."} +{"_id": "5267", "text": "A commensal bacterial infectious disease that results_in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces gerencseriae, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus, has_material_basis_in Actinomyces meyeri, has_material_basis_in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures."} +{"_id": "5270", "text": "A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE."} +{"_id": "5273", "text": "A viral infectious disease that results_in infection in cattle, located_in intestine, has_material_basis_in Bovine viral diarrhea virus 1, which is transmitted_by ingestion of infected food, or transmitted_by nasal secretions. The infection has_symptom lesions in the mucosa of digestive tract, has_symptom necrosis of lymphoid tissue, has_symptom hoof inflammation and dermatitis, and has_symptom diarrhea."} +{"_id": "5276", "text": "An agnosia that is a loss of the ability to perceive a whole object while perceiving only parts of details."} +{"_id": "5279", "text": "A Charcot-Marie-Tooth disease characterized by motor conduction velocities above and below 38 m/s."} +{"_id": "5282", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by nematodes of the superfamily Trichostrongyloidea."} +{"_id": "5285", "text": "An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months."} +{"_id": "5288", "text": "An osteochondrodysplasia that results_in shortened long bones and distinct facial abnormalities."} +{"_id": "5291", "text": "A trichomoniasis that is caused by a singled-celled protozoan parasite Trichomonas tenax, which is transmitted through oral droplets, by kissing, or on fomites such as eating utensils. Trichomonas tenax causes periodonitis and bronchopulmonary trichomoniasis by aspiration from the oropharynx."} +{"_id": "5294", "text": "An amino acid metabolic disorder that involves abnormally high levels of the amino acid glycine in bodily fluids and tissues."} +{"_id": "5297", "text": "A Simplexvirus infectious disease that results_in inflammation located_in brain and located_in meninges, has_material_basis_in Human herpesvirus 2 and has_symptom headache, has_symptom lesions in the brain, and has_symptom cerebral hemorrhage."} +{"_id": "5300", "text": "A pigmentation disease characterized by progressively pigmented and depigmented macules, often mixed in a reticulate pattern, concentrated on the dorsal extremities."} +{"_id": "5303", "text": "A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity."} +{"_id": "5306", "text": "A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets."} +{"_id": "5309", "text": "A bone development disease characterized by short fingers and toes."} +{"_id": "5312", "text": "A thoracic cancer that originates in the mammary gland."} +{"_id": "5315", "text": "A gastrointestinal anthrax that results_in infection located_in mucosa of oropharynx, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite."} +{"_id": "5318", "text": "An intrinsic cardiomyopathy that has_material_basis_in autosomal dominant inheritance and that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause."} +{"_id": "5321", "text": "A syndrome that involves abnormality of collagen synthesis in lamellar bones, with manifestations limited to the skeleton. The initial symptom is frequently spontaneous fractures."} +{"_id": "5324", "text": "An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image."} +{"_id": "5327", "text": "An extrahepatic bile duct carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "5330", "text": "A uterine corpus cancer that is derived_from the inner lining of the uterus."} +{"_id": "5333", "text": "An autosomal dominant disease characterized by problems with regulating body temperature and other abnormalities affecting many parts of the body; caused_by mutations in the CRLF1 gene."} +{"_id": "5336", "text": "A nutritional deficiency disease that is characterized by thinning of the hair (often with loss of hair color), and red scaly rash around the eyes, nose, and mouth."} +{"_id": "5339", "text": "An autoimmune disease of skin and connective tissue that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested."} +{"_id": "5342", "text": "A malignant melanoma of choroid and spindle cell intraocular melanoma that is located_in the choroid."} +{"_id": "5345", "text": "A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated."} +{"_id": "5348", "text": "A glioblastoma multiforme that is characterized by the most frequent number of mutation of the Neurofibromin 1 gene."} +{"_id": "5351", "text": "An amino acid metabolic disorder that involves accumulation of ammonia in the blood."} +{"_id": "5354", "text": "A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior."} +{"_id": "5357", "text": "A musculoskeletal system disease that affects the muscles."} +{"_id": "5360", "text": "A Chromadorea infectious disease that involves infection by parasitic nematodes of the order Spirurida."} +{"_id": "5363", "text": "A Measles virus infectious disease that results_in inflammation located_in brain, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom headache, has_symptom irritability, has_symptom drowsiness, has_symptom abnormal reflexes, has_symptom involuntary movements, has_symptom hemiplagia, has_symptom ataxia, has_symptom nystagmus, and has_symptom dysphasia."} +{"_id": "5366", "text": "A Salmonella infectious disease that involves inflammation of the stomach and intestines caused by Salmonella infection. The symptoms include diarrhea, vomiting, abdominal pain, fever and weakness."} +{"_id": "5369", "text": "A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring."} +{"_id": "5372", "text": "A hypersensitivity reaction type II disease of the eyes, ears, nose and throat."} +{"_id": "5375", "text": "A viral infectious disease that results_in infection in animals and humans, has_material_basis_in Simplexvirus."} +{"_id": "5378", "text": "A carcinoma of bladder that is manifested in squamous cells of the bladder."} +{"_id": "5381", "text": "A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading to hereditary angioedema (HAE) involving swelling due to leakage of fluid from blood vessels into connective tissue."} +{"_id": "5384", "text": "A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements."} +{"_id": "5387", "text": "A mycoplasmal pneumonia that is a highly contagious infection usually associated with pleurisy of cattle, goats, and sheep, which is caused by bacteria of the genus Mycoplasma (especially M. mycoides)."} +{"_id": "5390", "text": "A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells."} +{"_id": "5393", "text": "A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations."} +{"_id": "5396", "text": "A specific phobia that is characterized by a fear of flying."} +{"_id": "5399", "text": "An osteochondrodysplasia that results_in inward turning of lower leg, located_in tibia, which fails to develop normally."} +{"_id": "5402", "text": "A dysostosis that results_in abnormal fusing of adjacent bones."} +{"_id": "5405", "text": "A cardiovascular system disease that involves the heart's electrical conduction system."} +{"_id": "5408", "text": "An ocular cancer that has_material_basis_in melanocytes and is located_in the eye."} +{"_id": "5411", "text": "A Chlamydophila infectious disease that involves Chlamydophila pneumoniae infection, characterized by interstitial infiltrates and respiratory distress."} +{"_id": "5414", "text": "A subcutaneous mycosis that results_in fungal infection located_in skin and located_in subcutaneous tissue, has_material_basis_in Ascomycota phylum members."} +{"_id": "5417", "text": "A herpes simplex that results_in infection located_in skin of the finger, toe, or thumb, has_material_basis_in Human herpesvirus 1 and has_material_basis_in Human herpesvirus 2 and has_symptom lesions, has_symptom fever, and has_symptom swollen lymph nodes."} +{"_id": "5420", "text": "An endocrine system disease that is located_in the pancreas."} +{"_id": "5423", "text": "A kidney sarcoma that has_material_basis_in clear cells that are characterized as cells that look clear when viewed under a microscope."} +{"_id": "5426", "text": "An inflammatory bowel disease characterized by inflammation located_in stomach and located_in duodenum, has_symptom nausea, has_symptom vomiting, has_symptom weight loss and has_symptom loss of appetite."} +{"_id": "5429", "text": "A bone disease that results_in an interruption of blood supply located_in bone."} +{"_id": "5432", "text": "An autosomal dominant disease characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities."} +{"_id": "5435", "text": "A galactosemia that involves an accumulation of galactose and galactitol secondary to the decreased conversion of galactose to galactose-1-phosphate by galactokinase."} +{"_id": "5438", "text": "A vulva carcinoma that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in Bartholin's gland."} +{"_id": "5441", "text": "A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper."} +{"_id": "5444", "text": "A pneumonia located_in the lung parenchyma of unknown cause."} +{"_id": "5447", "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Nidovirales viruses."} +{"_id": "5450", "text": "A colon carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "5453", "text": "A histoplasmosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and results_in_formation_of nodules, results_in_formation_of ulcers and results_in_formation_of osteolytic bone lesions."} +{"_id": "5456", "text": "A B cell deficiency that is caused by a reduction in all types of gamma globulins."} +{"_id": "5459", "text": "A cerebrum cancer that affects the lymph cells and derives_from the brain."} +{"_id": "5462", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis."} +{"_id": "5465", "text": "A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue."} +{"_id": "5468", "text": "A vulva carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "5471", "text": "A physical disorder characterized by mandibular hypoplasia or agnathia, ventromedial auricular malposition (melotia) and/or auricular fusion (synotia), and microstomia with oroglossal hypoplasia or aglossia. Holoprosencephaly is the most commonly identified association, but skeletal, genitourinary and cardiovascular anomalies and situs inversus have been reported."} +{"_id": "5474", "text": "A mental depression that involves presentation of depressive symptoms only during a specific season of the year."} +{"_id": "5477", "text": "A primary bacterial infectious disease that involves infection of the intestine by the bacterium Escherichia coli, caused by consumption of contaminated food and water. Some strains of Escherichia coli produce Shiga toxin, which cause severe illness. The symptoms include severe stomach cramps, fever, diarrhea (sometimes bloody), and vomiting."} +{"_id": "5480", "text": "A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors."} +{"_id": "5483", "text": "A vascular disease that is characterized by blood vessel obstruction resulting from the release of cholesterol from the inside of blood vessels along the bloodstream."} +{"_id": "5486", "text": "An agnosia that is a loss of the ability to visually recognize objects."} +{"_id": "5489", "text": "A parasitic helminthiasis infectious disease that involves infection caused by parasitic worms, which are bilaterian, unsegmented, soft-bodied invertebrate animals with no body cavity."} +{"_id": "5492", "text": "A strongyloidiasis that involves parasitic infection by the filariform larvae of Strongyloides stercoralis, which penetrate the human skin causing urticarial rashes in the buttocks and waist areas."} +{"_id": "5495", "text": "A Varicellovirus infectious disease that results_in infection located_in brain, has_material_basis_in Human herpesvirus 3 and has_symptom lethargy, has_symptom rash, has_symptom confusion, has_symptom hallucinations, has_symptom weakness, has_symptom paralysis, has_symptom numbness, and has_symptom parasthesias."} +{"_id": "5498", "text": "A vascular disease that is located_in the capillaries."} +{"_id": "5501", "text": "An agammaglobulinemia that is a condition where there is co-occurrence of deficient cell-mediated immunity and benign thymoma."} +{"_id": "5504", "text": "A muscular dystrophy which begins at the lower legs and affects the shoulder region earlier and more severely than distal arm."} +{"_id": "5507", "text": "A gallbladder sarcoma that is located_in the gallbladder."} +{"_id": "5510", "text": "A leiomyosarcoma and sarcoma of liver that is located_in the liver."} +{"_id": "5513", "text": "An endocrine gland cancer located_in the pituitary gland located at the base of the brain."} +{"_id": "5516", "text": "A sarcoma and malignant neoplasm of heart that is located_in the heart."} +{"_id": "5519", "text": "A sarcoma of the rectum that results_in lesions that are located_in the rectum."} +{"_id": "5522", "text": "A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize."} +{"_id": "5525", "text": "A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection."} +{"_id": "5528", "text": "An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene."} +{"_id": "5531", "text": "A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding."} +{"_id": "5534", "text": "A cryptococcosis that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Filobasidiella neoformans and has_symptom gastointestinal bleeding, has_symptom diarrhea and has_symptom abdominal pain."} +{"_id": "5537", "text": "A hypersensitivity reaction type II disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots."} +{"_id": "5540", "text": "A communication disorder that involves the processing of linguistic information."} +{"_id": "5543", "text": "A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax."} +{"_id": "5546", "text": "A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation."} +{"_id": "5549", "text": "An Enterovirus infectious disease that results_in inflammation located_in meningeal cluster, has_material_basis_in Human enterovirus B, which is transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom headache, and has_symptom neck pain."} +{"_id": "5552", "text": "An ocular malanoma that derives_from melanocytes in the uveal tract that results_in_formation_of spindle-shaped cells."} +{"_id": "5555", "text": "A viral infectious disease that results_in infection in domesticated housecats, has_material_basis_in Feline immunodeficiency virus, which is transmitted_by contact with the infected cat's saliva during deep bite wounds, and transmitted_by congenital method. The virus attacks the immune system infecting CD4+ and CD8+ T lymphocytes, B lymphocytes, and macrophages. Some of the symptoms are loss of weight, malaise, pyrexia, anemia, gastroenteritis, gingivitis, stomatitis, diarrhea, infections of the skin, eyes, urinary tract, respiratory tract, and diseases of the nervous system."} +{"_id": "5558", "text": "A Chromadorea infectious disease that involves infection by parasitic nematodes of the order Oxyurida."} +{"_id": "5561", "text": "An inherited metabolic disorder characterized by the body's inability to break down proteins and fats to produce energy. It is a disorder of fatty acid,amino acid, and choline metabolism and has an autosomal recessive inheritance pattern. It is caused by mutations in the ETFA, ETFB and ETFDH genes. It presents three clinical phenotypes: a neonatal-onset form with congenital anomalies (type I), a neonatal-onset form without congenital anomalies (type II), and a late-onset form (type III). The neonatal-onset forms are usually fatal."} +{"_id": "5564", "text": "A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has_symptom stiff body, has_symptom muscle spasms, has_symptom difficulty in breathing, and has_symptom exhaustion."} +{"_id": "5567", "text": "A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery."} +{"_id": "5570", "text": "A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions."} +{"_id": "5573", "text": "A urinary bladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "5576", "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue."} +{"_id": "5579", "text": "An embryonal rhabdomyosarcoma located in the parameningeal region."} +{"_id": "5582", "text": "A Charcot-Marie-Tooth disease has_material_basis_in X-linked inheritance of a point mutation in the connexin-32 gene."} +{"_id": "5585", "text": "An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe."} +{"_id": "5588", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys."} +{"_id": "5591", "text": "An idiopathic generalized epilepsy that is characterized by febrile seizures often with accessory afebrile generalized tonic-clonic seizures with childhood onset."} +{"_id": "5594", "text": "A candidiasis that involves fungal infection of the esophagus by Candida albicans in immunocompromised people, resulting in lesions, bleeding, painful swallowing and substernal pain."} +{"_id": "5597", "text": "A Cytomegalovirus infectious disease that results_in infection, located_in colon, has_material_basis_in Human herpesvirus 5, which results_in_formation_of ulcer, has_symptom watery or bloody diarrhea, has_symptom abdominal pain, has_symptom fever, and has_symptom weight loss."} +{"_id": "5600", "text": "A pancreatic carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "5603", "text": "An Epstein-Barr virus infectious disease and is_a carcinoma that derives_from epithelial cells, has_material_basis_in Human herpesvirus 4, which causes a growth activation of the epithelial cells that it infects."} +{"_id": "5606", "text": "A suppurative otitis media with sudden onset and a short course."} +{"_id": "5609", "text": "A dissociative disorder where he continuity of the patient's memory is disrupted. Patients with dissociative amnesia have recurrent episodes in which they forget important personal information or events, usually connected with trauma or severe stress."} +{"_id": "5612", "text": "A disease of mental health that involves the impairment in normal sexual functioning."} +{"_id": "5615", "text": "A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm."} +{"_id": "5618", "text": "An angiostrongyliasis that involves infection of the intestine by Angiostrongylus costaricensis, which is characterized by the formation of granulomas with heavy eosinophilic infiltration in the abdominal cavity."} +{"_id": "5621", "text": "An endometrial carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "5624", "text": "An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot."} +{"_id": "5627", "text": "An adnexa disease that is located_in the eye socket."} +{"_id": "5630", "text": "An acrocephalosyndactylia that has_material_basis_in a genetic mutation in the TWIST1 gene which results_in premature fusion located_in skull."} +{"_id": "5633", "text": "A syphilis that is characterized as the second stage of syphilis which appears from 2 to 6 months after primary infection, and is marked by lesions especially in the skin but also in organs and tissues, and that lasts from 3 to 12 weeks."} +{"_id": "5636", "text": "A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure."} +{"_id": "5639", "text": "A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils."} +{"_id": "5642", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma."} +{"_id": "5645", "text": "A lice infestation that involves parasitic infestation by pubic lice Pthirus pubis, which are found in the pubic hair, less commonly in eyebrows, eyelashes, beard, mustache, armpit, perianal area, groin, trunk and scalp. The symptoms include itching in the pubic and groin area. Intense itching leads to scratching which can cause sores and secondary bacterial infection of the skin."} +{"_id": "5648", "text": "A disorder that has an available objective mechanical test (such as chemical tests or brain scans), and are diagnosed only by behavioral syndrome (such as those in the Diagnostic and Statistical Manual of Mental Disorders (DSM)."} +{"_id": "5651", "text": "An encephalomyelitis characterized by inflammation located_in brain and located_in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection."} +{"_id": "5654", "text": "A type of ALS with juvenile onset caused_by mutation located_in HNRNPA1 gene located_in chromosome 12."} +{"_id": "5657", "text": "A Haemophilus influenzae infectious disease that is caused by the strains of Haemophilus influenzae resulting in pleural effusions. This disease occurs in individuals with disorders that impaired the normal defense mechanisms and with pre-existing lung disease. H. influenzae causes bronchopneumonia making the patients wheezy and progressively more breathless."} +{"_id": "5660", "text": "A trypanosomiasis that is a chronic, sexually transmitted disease of horses and other equids, caused by the protozoan parasite Trypanosoma equiperdum, which is characterized by swelling of the genitalia, cutaneous plaques and neurological signs."} +{"_id": "5663", "text": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia."} +{"_id": "5666", "text": "A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye."} +{"_id": "5669", "text": "A Simplexvirus infectious disease that results_in inflammation located_in mucosa of mouth, has_material_basis_in Human herpesvirus 1, and has_symptom cold sores, has_symptom bad breath, and has_symptom fever."} +{"_id": "5672", "text": "An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories."} +{"_id": "5675", "text": "A color blindness that is characterised by a selective deficiency of blue vision, has_material_basis_in autosomal dominant inheritance of a mutation in the OPN1SW gene and is associated with a deficiency or absence of blue-sensitive cone photoreceptor function."} +{"_id": "5678", "text": "A Reoviridae infectious disease that results_in infection in vertebrates, has_material_basis_in Orbivirus, which is transmitted_by mosquitoes, transmitted_by midges, transmitted_by gnats, transmitted_by sandflies, and transmitted_by ticks."} +{"_id": "5681", "text": "An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy."} +{"_id": "5684", "text": "A tracheal disease which involves bacterial infection of the trachea often caused by Staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. The symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions."} +{"_id": "5687", "text": "A non-Hodgkin lymphoma that has_material_basis_in B cells."} +{"_id": "5690", "text": "An agnosia that is a loss of the ability to distinguish visual shapes."} +{"_id": "5693", "text": "A renal infectious disease and is_a Human immunodeficiency virus infectious disease that results_in infection located_in kidney, has_material_basis_in has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom nephrotic-range proteinuria (>3.5 g/d), has_symptom azotemia, has_symptom hypoalbuminemia, and has_symptom hyperlipidemia."} +{"_id": "5696", "text": "A brain cancer that is located_in the infratentorial region."} +{"_id": "5699", "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in cervix, has_material_basis_in human papillomavirus (types 16 or 18), which cause malignant tumors in squamous epithelium of cervix."} +{"_id": "5702", "text": "A Bartholin's gland carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "5705", "text": "An autosomal recessive disease that is characterized by inverted facial expressions in association with a severe and early-onset form of dysfunctional urinary voiding."} +{"_id": "5708", "text": "A X-linked hereditary ataxia that is characterized by adult-onset progressive intention tremor and gait ataxia, has_material_basis_in expanded trinucleotide repeat of the FMR1 gene that results_in a toxic gain of function of FMR1 RNA."} +{"_id": "5711", "text": "An atrioventricular block characterized by the presence of conduction system disease of any form, which is diagnosed on or before 28 days of life."} +{"_id": "5714", "text": "An autosomal dominant disease characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis."} +{"_id": "5717", "text": "An ehrlichiosis that results_in infection located_in monocyte or located_in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash."} +{"_id": "5720", "text": "An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as \\sore throat\\\". The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.\""} +{"_id": "5723", "text": "An endocardium disease that is characterized by a thickening of the inmost lining of the heart chambers due to an increase in the amount of supporting connective tissue and elastic fibers."} +{"_id": "5726", "text": "A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales."} +{"_id": "5729", "text": "A heart valve disease that is characterized by repeated inflammation with fibrinous repair. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.It is caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage."} +{"_id": "5732", "text": "An amyloidosis that is characterized by a loss of sensation in the extremities, cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis resulting from abnormal deposits of amyloid protein in the body's organs and tissues and has_material_basis_in autosomal dominant inheritance of mutations in the TTR gene."} +{"_id": "5735", "text": "An integumentary system disease that is located_in nail."} +{"_id": "5738", "text": "A viral infectious disease that affects CD8 lymphocytes, has_material_basis_in Human T-lymphotropic virus 2, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The person infected with HTLV-2 develop neurologic diseases resembling tropical spastic paraparesis."} +{"_id": "5741", "text": "A germ cell cancer that lacks histologic differentiation. It usually refers to a tumor in the brain."} +{"_id": "5744", "text": "An ovary serous adenocarcinoma that has_material_basis_in glandular epithelium, in which cystic accumulations of retained secretions are formed."} +{"_id": "5747", "text": "A carcinoma in situ that is characterized by the spread of cancer in the respiratory system and the lack of invasion of surrounding tissues."} +{"_id": "5750", "text": "A gastroenteritis that involves inflammation of the stomach and intestines caused by viruses. The symptoms include abdominal cramps and pain, fever, watery diarrhea, loss of appetite, nausea, and vomiting."} +{"_id": "5753", "text": "A multiple myeloma that is a slow growing type of myeloma in which abnormal plasma cells results_in too much of a single type of monoclonal antibody."} +{"_id": "5756", "text": "An embryonal testis carcinoma that is located within a tubule."} +{"_id": "5759", "text": "An adenosarcoma and malignant ovarian endometroid tumorthat is located_in the ovary."} +{"_id": "5762", "text": "A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling."} +{"_id": "5765", "text": "A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods."} +{"_id": "5768", "text": "A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread."} +{"_id": "5771", "text": "A parasitic helminthiasis infectious disease that involves zoonotic infection caused by Moniezia expansa, the common tapeworm of sheep."} +{"_id": "5774", "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine in pigs, has_material_basis_in Transmissible gastroenteritis virus, which is transmitted_by ingestion of food contaminated with feces. The infection has_symptom vomiting, has_symptom watery yellow diarrhea, has_symptom weight loss, and has_symptom dehydration."} +{"_id": "5777", "text": "An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage."} +{"_id": "5780", "text": "A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern."} +{"_id": "5783", "text": "A bone structure disease characterized by an appreciable lateral deviation in the normally straight vertical line of the spine."} +{"_id": "5786", "text": "An oral cavity cancer that is located_in the salivary gland."} +{"_id": "5789", "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Sapovirus, which is transmitted_by ingestion of contaminated food. The infection has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, and has_symptom diarrhea."} +{"_id": "5792", "text": "A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate."} +{"_id": "5795", "text": "An autosomal dominant disease characterized by the higher than normal tendency to develop breast and ovarian cancers in genetically related families."} +{"_id": "5798", "text": "A maxillary sinusitis which lasts for 12 weeks or more."} +{"_id": "5801", "text": "An anal canal cancer that derives_from epithelial squamous cells."} +{"_id": "5804", "text": "A uterine cancer that is located_in the uterine corpus."} +{"_id": "5807", "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract."} +{"_id": "5810", "text": "A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause."} +{"_id": "5813", "text": "An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body."} +{"_id": "5816", "text": "A ciliopathy that is characterized by congenital malformation of the brainstem and agenesis or hypoplasia of the cerebellar vermis leading to an abnormal respiratory pattern, nystagmus, hypotonia, ataxia, and delay in achieving motor milestones."} +{"_id": "5819", "text": "A secondary syphilis that involves infection of the liver by the spirochete Treponema pallidum, which results in the formation of hepatic lesions."} +{"_id": "5822", "text": "An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures."} +{"_id": "5825", "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Norovirus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by fomites. The infection has_symptom vomiting, has_symptom watery diarrhea, has_symptom abdominal cramps, has_symptom nausea, and has_symptom fever."} +{"_id": "5828", "text": "A sphenoid sinusitis which lasts for 12 weeks or more."} +{"_id": "5831", "text": "A recurrent hematologic cancer that is located_in bone marrow and is characterized by the production of too many lymphocytes."} +{"_id": "5834", "text": "An opportunistic mycosis that results_in fungal infection located_in cutaneous tissues or located_in subcutaneous tissues followed by a traumatic implantation of fungal elements through the skin, has_material_basis_in Mucorales molds and has_symptom necrotic lesions which progressively evolve from the epidermis into dermis and even muscle."} +{"_id": "5837", "text": "An osteochondrodysplasia characterized by short stature, joint laxity, scoliosis, and advanced carpal ossification with a delta phalanx."} +{"_id": "5840", "text": "A lymphoma by site that is manifested in immune system cells called lymphocytes."} +{"_id": "5843", "text": "A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "5846", "text": "A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph."} +{"_id": "5849", "text": "A brucellosis involving an infection caused by Brucella canis in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly."} +{"_id": "5852", "text": "A bronchus cancer that has_material_basis_in squamous cells, mucus-secreting cells, and intermediate cells."} +{"_id": "5855", "text": "A diphtheria that is characterized by a mucopurulent nasal discharge (containing both mucus and pus) which may become blood-tinged. A white membrane usually forms on the nasal septum. The disease is usually fairly mild because of apparent poor systemic absorption of toxin in this location, and it can be terminated rapidly by antitoxin and antibiotic therapy."} +{"_id": "5858", "text": "A primary Bacillaceae infectious disease that is caused by ingestion of food contaminated with Bacillus cereus, which produces enterotoxins in the intestine. The symptoms include vomiting, abdominal cramps, fever and diarrhea."} +{"_id": "5861", "text": "An adrenal gland cancer that derives_from immature neuroblastic cells."} +{"_id": "5864", "text": "A muscle cancer that is located_in striated muscle and has_material_basis_in rhabdoid cells which are large cells with eccentrically located nuclei and abundant, eosinophilic cytoplasm."} +{"_id": "5867", "text": "A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone\\ and symptoms starting before seven years of age.\""} +{"_id": "5870", "text": "An extrapulmonary tuberculosis that is located_in urogenital system."} +{"_id": "5873", "text": "A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules."} +{"_id": "5876", "text": "An endocrine gland cancer located_in the adrenal glands which are located above the kidneys."} +{"_id": "5879", "text": "A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue."} +{"_id": "5882", "text": "An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii."} +{"_id": "5885", "text": "A nasal cavity carcinoma that has_material_basis_in squamous cells."} +{"_id": "5888", "text": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint."} +{"_id": "5891", "text": "A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis."} +{"_id": "5894", "text": "An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia."} +{"_id": "5897", "text": "An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63."} +{"_id": "5900", "text": "A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms."} +{"_id": "5903", "text": "A glycogen metabolism disorder that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types."} +{"_id": "5906", "text": "An adamantinoma of long bone that is located_in the tibia."} +{"_id": "5909", "text": "A carcinoma that is characterized by a BRD4-NUT translocation involving the rearrangement of the bromodomain-containing protein 4 (BRD4) and the gene encoding nuclear protein of the testis (NUT) at 15q14, BRD4-NUT t(15;19)(q14;q13.1) and arises from midline epithelial structures, most commonly the head, neck, and mediastinum."} +{"_id": "5912", "text": "A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer."} +{"_id": "5915", "text": "A rhabdomyosarcoma and sarcoma of prostate that is located_in the prostate."} +{"_id": "5918", "text": "A fallopian tube cancer that is located_in the fallopian tube."} +{"_id": "5921", "text": "An agnosia that is a loss of the ability to perceive any auditory information but whose hearing is intact."} +{"_id": "5924", "text": "An ectothrix infectious disease that results_in anthropophilic fungal infection located_in scalp and located_in hair, has_material_basis_in Trichophyton megninii."} +{"_id": "5927", "text": "A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant."} +{"_id": "5930", "text": "An autosomal dominant disease characterized by increases risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata."} +{"_id": "5933", "text": "A embryonal cancer that is located in the kidney."} +{"_id": "5936", "text": "A mansonelliasis that involves parasitic infection by the nematode Mansonella perstans, which resides in body cavities and the surrounding tissues causing angioedema, pruritus, fever, headaches, arthralgias, and neurologic manifestations. Midges transmit the disease."} +{"_id": "5939", "text": "A pancreas adenocarcinoma that derives_from pancreatic duct cells."} +{"_id": "5942", "text": "A hematologic cancer that is located_in the blood or bone marrow that doesn't respond to treatment."} +{"_id": "5945", "text": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."} +{"_id": "5948", "text": "A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever."} +{"_id": "5951", "text": "A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress."} +{"_id": "5954", "text": "A dermatitis that selectively affects the hands and feet."} +{"_id": "5957", "text": "An autosomal dominant disease that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene)."} +{"_id": "5960", "text": "A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system."} +{"_id": "5963", "text": "An ancylostomiasis that involves infection of the intestine in dogs and humans by the nematode Ancylostoma caninum. In humans, the larvae migrate to the intestine causing eosinophilic enteritis. They have also been implicated as a cause of diffuse unilateral subacute neuroretinitis."} +{"_id": "5966", "text": "A syndrome that is acterized by a pattern of congenital anomalies including choanal atresia and malformations of the heart, inner ear, and retina."} +{"_id": "5969", "text": "A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body."} +{"_id": "5972", "text": "A non-Hodgkin lymphoma that is characterized as an indolent non-Hodgkin's lymphoma and has_material_basis_in follicle center B-cells (centrocytes and centroblasts)."} +{"_id": "5975", "text": "A viral infectious disease that results_in bronchioloalveolar carcinoma in ovine, located_in lung, has_material_basis_in Jaagsiekte sheep retrovirus, characterized by proliferation of the pulmonary alveolar epithelium and occlusion of the alveoli and terminal bronchioles, presenting as a collection of benign growths of grandular origin."} +{"_id": "5978", "text": "A syndrome that results_in rheumatoid arthritis, splenomegaly and neutropenia."} +{"_id": "5981", "text": "An autosomal dominant cerebellar ataxia that is characterized by the early-onset of cerebellar signs and eye movement abnormalities with a very slow disease progression, and has_physical_basis_in a mutation in the SPTBN2 gene."} +{"_id": "5984", "text": "An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone."} +{"_id": "5987", "text": "An anthrax disease that results_in infection located_in skin, has_material_basis_in Bacillus anthracis, which is transmitted_by contact with infected animals or animal products. The infection has_symptom skin lesion that eventually forms an ulcer with a black center."} +{"_id": "5990", "text": "A Picornaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Cardiovirus."} +{"_id": "5993", "text": "A colitis caused_by inadequate blood supply to the colon."} +{"_id": "5996", "text": "A Simplexvirus infectious disease that results_in infection located_in brain, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2. The infection has_symptom headache, has_symptom fever, has_symptom personality and behavioral changes, has_symptom seizures, has_symptom partial paralysis, and has_symptom hallucinations."} +{"_id": "5999", "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain."} +{"_id": "6002", "text": "A mitral valve disease where one or both of the cusps of the mitral valve bulge or collapse backward in the left atrium during systole."} +{"_id": "6005", "text": "A bubonic plague that results_in a benign form of bubonic plague, has_symptom fever, has_symptom lymphadenitis, has_symptom headache and has_symptom prostration."} +{"_id": "6008", "text": "A middle ear carcinoma that has_material_basis_in squamous cells."} +{"_id": "6011", "text": "An opportunistic bacterial infectious disease that involves infection of the intestine caused by Morganella morganii."} +{"_id": "6014", "text": "A staphylococcal infectious disease that involves infection of the intestine caused by staphylococci, which produce toxins. The symptoms include diarrhea, abdominal pain, vomiting and nausea."} +{"_id": "6017", "text": "A combined T cell and B cell immunodeficiency that is caused by mutation in TNFRSF5 resulting in type 3 hyper-IgM immunodeficiency characterized by an inability of B cells to undergo isotype switching, an inability to mount an antibody-specific immune response, and a lack of germinal center formation."} +{"_id": "6020", "text": "A cell type benign neoplasm that from perivascular epithelioid cells."} +{"_id": "6023", "text": "An autosomal dominant disease characterized by short stature, moderate to sever intellectual disability, distinctive facial features and broad thumbs and first toes; additionally it can include eye abnormalities, heart and kidney defects, dental problems and obesity."} +{"_id": "6026", "text": "A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm."} +{"_id": "6029", "text": "A severe pre-eclampsia characterized by hemolysis, elevated liver enzyme and low platelet count."} +{"_id": "6032", "text": "A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8)."} +{"_id": "6035", "text": "A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones."} +{"_id": "6038", "text": "A personality disorder that is characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, emotional coldness and sometimes sexual apathy, with a simultaneous rich, elaborate and exclusively internal fantasy world."} +{"_id": "6041", "text": "A syndrome characterized by mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma. It is cause by homozygous mutation in the AP1S1 gene on chromosome 7q22."} +{"_id": "6044", "text": "A otitis media which involves transudation of fluid in the middle ear without pus formation."} +{"_id": "6047", "text": "An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods."} +{"_id": "6050", "text": "An endometrial carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "6053", "text": "A vulva cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "6056", "text": "A Varicellovirus infectious disease that results_in inflammation located_in meninges, has_material_basis_in Human herpesvirus 3, which reactivates after the primary infection. The infection has_symptom fever, has_symptom headache, has_symptom cervical rigidity, has_symptom seizure, has_symptom ataxia, and has_symptom skin lesions."} +{"_id": "6059", "text": "A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma."} +{"_id": "6062", "text": "A candidiasis that involves fungal infection of the outer ear canal caused by Candida species. The symptoms include discharge, tinnitus, pruritus, and a feeling of fullness in the ear resulting in scratching and further damage to the epidermis."} +{"_id": "6065", "text": "A spinal cancer that is located_in the spinal cord and has_material_basis_in glial cells."} +{"_id": "6068", "text": "A somatoform disorder that involves an excessive preoccupation or worry about having a serious illness."} +{"_id": "6071", "text": "A lipodystrophy characterized by abnormal subcutaneous adipose tissue distribution beginning in late childhood or early adult life."} +{"_id": "6074", "text": "A hepatobiliary benign neoplasm located_in the biliary tract."} +{"_id": "6077", "text": "A myopathy that is characterized by mitochondrial dysfunction."} +{"_id": "6080", "text": "A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea."} +{"_id": "6083", "text": "A basal ganglia disease characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language."} +{"_id": "6086", "text": "A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood."} +{"_id": "6089", "text": "A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells."} +{"_id": "6092", "text": "A malignant neoplasm that is manifested in the lower limb."} +{"_id": "6095", "text": "A RNA virus infectious disease that results_in infection, has_material_basis_in dsRNA viruses, which possess double-stranded RNA genomes."} +{"_id": "6098", "text": "A crustacean allergy triggered by Penaeus monodon."} +{"_id": "6101", "text": "A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly."} +{"_id": "6104", "text": "A cell type benign neoplasm that has_material_basis_in glial cells."} +{"_id": "6107", "text": "An intestinal disease that involves inflammation located_in intestine."} +{"_id": "6110", "text": "A chromosomal deletion syndrome that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes."} +{"_id": "6113", "text": "A Chromadorea infectious disease that involves infection of humans and domestic animals by parasitic roundworms with three lips on the anteriour end."} +{"_id": "6116", "text": "A human papilloma virus related cervical squamous cell carcinoma that results_in infection located_in cervix, has_material_basis_in human papillomavirus (types 16 or 18), which cause warty malignant tumors in squamous epithelium of cervix."} +{"_id": "6119", "text": "A rheumatic disease and collagen disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs."} +{"_id": "6122", "text": "A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems."} +{"_id": "6125", "text": "A biliary tract cancer that is located_in the gallbladder."} +{"_id": "6128", "text": "A neuromuscular disease characterized by congenital weakness, arthrogryposis, cleft palate, ptosis, myopathic facies, short stature, kykphoscoliosis, talipes deformities and susceptibility to malignant hyperthermia provoked by anesthesia; caused by homozygous mutation in the STAC3 gene on chromosome 12q13."} +{"_id": "6131", "text": "An adenovirus infectious disease that results_in inflammation located_in brain, has_material_basis_in Human adenovirus 2 or has_material_basis_in Human adenovirus 4. The symptoms include fever, stupor, nuchal rigidity, loss of consciousness and seizures."} +{"_id": "6134", "text": "An appendix cancer that is characterized by progressive accumulation of mucus-secreting tumor cells within the abdomen and pelvis."} +{"_id": "6137", "text": "An agnosia that is a loss of the ability to visually recognise an object while maintaining the use of non-visual sensory systems such as feeling, tapping, smelling, rocking or flicking the object to recognise the object."} +{"_id": "6140", "text": "A benign neoplasm that is classified by the organ system from which it is arising from."} +{"_id": "6143", "text": "A primary Helicobacter infectious disease that involves inflammation of the stomach lining caused by Candidatus Helicobacter heilmannii, which is associated with peptic ulceration."} +{"_id": "6146", "text": "An angiosarcoma and gallbladder sarcoma that is located_in the gallbladder."} +{"_id": "6149", "text": "A Reoviridae infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Rotavirus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by fomites. The infection has_symptom fever, has_symptom vomiting, has_symptom diarrhea, and has_symptom abdominal pain."} +{"_id": "6152", "text": "A severe combined immunodeficiency that results from defective IL7R expression causes T-B+NK+ SCID. Loss of IL-7R function leads to the loss of an antiapoptotic signal, resulting in a loss of T-cell selection in thymus."} +{"_id": "6155", "text": "A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness."} +{"_id": "6158", "text": "A metaphyseal dysplasia that has_material_basis_in mutation in PTH receptor which results_in short-limbed dwarfism."} +{"_id": "6161", "text": "A Parkinson's disease caused by mutations in the PINK1 gene located on chromosome 1p36.12."} +{"_id": "6164", "text": "An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies."} +{"_id": "6167", "text": "An osteosclerosis that has_material_basis_in a mutation of the LEMD3 gene which results_in a hyperdense bony cortex."} +{"_id": "6170", "text": "An intestinal benign neoplasm that has_material_basis_in epithelial tissue with glandular origin and is located_in the large intestine."} +{"_id": "6173", "text": "A bone structure disease that has_material_basis_in an abnormal curvature located_in vertebral column."} +{"_id": "6176", "text": "A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash."} +{"_id": "6179", "text": "A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions."} +{"_id": "6182", "text": "A acute laryngitis which is caused by viral infection."} +{"_id": "6185", "text": "A colonic benign neoplasm that has_material_basis_in epithelial tissue with glandular origin."} +{"_id": "6188", "text": "A fish allergy triggered by Gadus morhua."} +{"_id": "6191", "text": "A schistosomiasis that involves parasitic infection of the brain and spinal cord by Schistosoma haematobium, Schistosoma mansoni or Schistosoma japonicum causing acute or subacute myelopathy, focal central nervous system impairment, seizures and increased intracranial pressure."} +{"_id": "6194", "text": "An opportunistic mycosis that has_material_basis_in Pneumocystis jirovecii, located_in lymph node, located_in spleen, located_in liver and located_in bone marrow, results_in_formation_of lesions."} +{"_id": "6197", "text": "A small intestine cancer that is located_in the beginning section of the small intestine."} +{"_id": "6200", "text": "A acute sanguinous otitis media caused by an allergen."} +{"_id": "6203", "text": "A acute transudative otitis media which involves bloody effusion."} +{"_id": "6206", "text": "An alveolar soft part sarcoma and cervical soft tissue tumor and malignant neoplasm of cervix uteri that is located_in the cervix."} +{"_id": "6209", "text": "A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet."} +{"_id": "6212", "text": "A otomycosis which is persistent and long-lasting or recurrent."} +{"_id": "6215", "text": "A hypogonadism that is characterized by the lack of mature male germ cells and testicular hormones."} +{"_id": "6218", "text": "A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy."} +{"_id": "6221", "text": "An ectothrix infectious disease that results_in geophilic and zoophilic fungal infection located_in skin, located_in scalp and located_in hair, has_material_basis_in Microsporum nanum, which results_in_formation_of chronic non-inflammatory lesions in pigs and humans."} +{"_id": "6224", "text": "A cholesteatoma which involves invasion of the squamous tissue into a localized area of bony erosion of the ear canal. It may develop spontaneously or as a consequence of infection, trauma or surgery."} +{"_id": "6227", "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the urinary bladder caused by Trichomonas vaginalis. The symptoms include pain during urination, foul urine odor and abnormal urine color."} +{"_id": "6230", "text": "A idiopathic interstitial pneumonia which develops suddenly and is severe. Initially, the lung shows edema, hyaline membranes, and interstitial acute inflammation. Later,it develops loose organizing fibrosis, mostly within alveolar septa and type II pneumocyte hyperplasia. Fever, cough, and difficulty breathing develop over 1 to 2 weeks, typically progressing to acute respiratory failure."} +{"_id": "6233", "text": "An agnosia that is a loss of the ability to comprehending the meaning of written words."} +{"_id": "6236", "text": "A capillariasis that involves infection of the intestine with Capillaria causing abdominal pain, weight loss, stomach growling, depressed levels of potassium and albumin in the blood, and diarrhea."} +{"_id": "6239", "text": "A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability."} +{"_id": "6242", "text": "A carcinoma that is an early development defined by the absence of invasion of surrounding tissues."} +{"_id": "6245", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Fasciolopsis buski. The symptoms include diarrhea, abdominal pain, fever, ascites, anasarca and intestinal obstruction."} +{"_id": "6248", "text": "A syndrome characterized by exocrine pancreatic insufficiency, bone marrow failure and skeletal abnormalities."} +{"_id": "6251", "text": "A laryngeal carcinoma that has_material_basis_in squamous cells."} +{"_id": "6254", "text": "An epilepsy syndrome that is located_in an area of the brain other than the temporal lobe."} +{"_id": "6257", "text": "A acute transudative otitis media with thin, watery and sterile effusion."} +{"_id": "6260", "text": "An osteochondrodysplasia that results_in abnormalities of bone growth located_in vertebral column, located_in epiphysis, located_in metaphysis."} +{"_id": "6263", "text": "A monogenic disease that is characterized by glomerulonephritis, endstage kidney disease, and hearing loss."} +{"_id": "6266", "text": "A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart."} +{"_id": "6269", "text": "A fruit allergy triggered by Prunus avium plant fruit food product."} +{"_id": "6272", "text": "A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol."} +{"_id": "6275", "text": "A viral infectious disease that results_in infection located in skin of mice, has_material_basis_in Ectromelia virus. The infection has_symptom swelling of the feet, has_symptom gangrene, and has_symptom lesions on the skin."} +{"_id": "6278", "text": "A thyroid carcinoma that has_material_basis_in follicular cells."} +{"_id": "6281", "text": "A vascular cancer that is characterized by an encapsulated, firm round mass at the bifurcation of the common carotid artery."} +{"_id": "6284", "text": "A respiratory system disease which involves the lower respiratory tract."} +{"_id": "6287", "text": "A childhood renal Wilms cancer that occurs in children. It encompasses two histologically distinct but grossly indistinguishable lesions: cystic nephroma and cystic partially differentiated nephroblastoma (CPDN)."} +{"_id": "6290", "text": "Alpha thalassemia is a thalassemia involving the genes HBA1and HBA2 hemoglobin genes."} +{"_id": "6293", "text": "A hypothyroidism that is present at birth."} +{"_id": "6296", "text": "A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision."} +{"_id": "6299", "text": "An autosomal recessive disease that is characterized by the buildup of thick, sticky mucus that can damage many organs."} +{"_id": "6302", "text": "An angiosarcoma and sarcoma of the mediastinum that is located_in the mediastinum."} +{"_id": "6305", "text": "A substance dependence that involves the continued use of drugs despite problems related to use of the substance."} +{"_id": "6308", "text": "A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia."} +{"_id": "6311", "text": "A cholangitis that is characterized_by an inflammation that is located_in the gallbladder."} +{"_id": "6314", "text": "An agnosia that is a loss of the ability to comprehend the succession and duration of events."} +{"_id": "6317", "text": "A hematologic cancer located_in the central nervous system."} +{"_id": "6320", "text": "An aspergillosis that involves an allergic reaction due to the spores of Aspergillus moulds (A. fumigatus), which colonizes the mucus in the airways causing inflammation. The disease has_symptom cough, has_symptom wheezing and has_symptom fever."} +{"_id": "6323", "text": "An inherited metabolic disorder that involves peroxisome malfunction."} +{"_id": "6326", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears."} +{"_id": "6329", "text": "A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart."} +{"_id": "6332", "text": "A diphtheria that involves a bluish white membrane formation on the larynx. It can be an extension of the nasopharyngeal diphtheria. This membrane can lead to airway obstruction, coma, and death. Symptoms include fever, hoarseness, and a barking cough."} +{"_id": "6335", "text": "A tonsil cancer that has_material_basis_in squamous cells."} +{"_id": "6338", "text": "A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen."} +{"_id": "6341", "text": "An acquired metabolic disease that involves abnormal deposited of amyloid proteins in organs and/or tissues."} +{"_id": "6344", "text": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness."} +{"_id": "6347", "text": "A dental enamel hypoplasia characterized by abnormal enamel formation."} +{"_id": "6350", "text": "A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin without elevation of liver alanine transaminase and aspartate transaminase enzymes as a result of the deficient ability of hepatocytes to secrete conjugated bilirubin into the bile."} +{"_id": "6353", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Nipah virus, which is transmitted_by direct contact with sick person or animals, or their contaminated tissues. The infection has_symptom dizziness, has_symptom drowsiness, has_symptom altered consciousness, has_symptom disorientation, and has_symptom coma."} +{"_id": "6356", "text": "An Ehlers-Danlos syndrome that is characterized by aged appearance, developmental delay, short stature, craniofacial disproportion, generalized osteopenia, defective wound healing, hypermobile joints, hypotonic muscles, and loose but elastic skin and has_material_basis_in compound heterozygous mutation in the B3GALT6 gene."} +{"_id": "6359", "text": "A pseudohermaphroditism that is characterized by the persistence of Mullerian duct derivatives (i.e. uterus, cervix, fallopian tubes and upper two thirds of vagina) in a phenotypically and karyotypically male."} +{"_id": "6362", "text": "A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts."} +{"_id": "6365", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma."} +{"_id": "6368", "text": "A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus."} +{"_id": "6371", "text": "A vaginitis that is characterized by a grayish vaginal discharge usually of foul odor and the presence of Gardnerella vaginalis."} +{"_id": "6374", "text": "A neurodegenerative disease characterized by spastic paraplegia, axonal neuropathy, dysarthria, acoustic startle, and congenital optical atrophy. It is caused by homozygous mutation in the KLC2 gene on chromosome 11q13.2."} +{"_id": "6377", "text": "An upper respiratory tract disease characterized by the swelling of the uvula to 3-5 times its normal size."} +{"_id": "6380", "text": "A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms."} +{"_id": "6383", "text": "A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint."} +{"_id": "6386", "text": "An autosomal recessive disease characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers. In 90% of the cases it is caused by mutations in the WRN gene, located_in chromosome 8."} +{"_id": "6389", "text": "An integumentary system disease that is located_in skin."} +{"_id": "6392", "text": "A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors."} +{"_id": "6395", "text": "A stage 0 cancer of the testis consisting of the uniform precursor of testicular germ cell tumors (GCTs). ITGCNU can be found in testicular tissue adjacent to GCTs in approximately 90 percent of adult cases and is found in all groups at risk for testicular cancer, including men with cryptorchid testes, prior testicular cancer, and individuals with abnormal sexual differentiation."} +{"_id": "6398", "text": "A schistosomiasis that involves parasitic infection of domestic animals by Schistosoma mattheei."} +{"_id": "6401", "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine of sheep and goats, has_material_basis_in Nairobi sheep disease virus, which is transmitted_by Rhipicephalus appendiculatus ticks. The infection has_symptom fever, has_symptom leukopenia, has_symptom rapid respiration, has_symptom anorexia, has_symptom profound depression, has_symptom diarrhea, and has_symptom dehydration."} +{"_id": "6404", "text": "A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma."} +{"_id": "6407", "text": "An amino acid metabolic disorder that involves the accumulation of argininosuccinic acid (ASA) in the blood and urine."} +{"_id": "6410", "text": "A renal tubular transport disease of the proximal renal tubes characterized by glucosuria, phosphaturia, generalized aminoaciduria and HCO3 wasting."} +{"_id": "6413", "text": "A tonsillitis which involves collection of pus beside the tonsil (peritonsillar space). It is caused by both aerobic and anaerobic bacteria. Commonly involved species include streptococci, staphylococci and hemophilus. Progressively worsening unilateral sore throat and pain during swallowing usually are the earliest symptoms. As the abscess develops, persistent pain in the peritonsillar area, fever, malaise, headache and a distortion of vowels informally known as \\hot potato voice\\\" may appear. Neck pain associated with tender, swollen lymph nodes, referred ear pain and halitosis are also common.\""} +{"_id": "6416", "text": "An alveolar soft part sarcoma that has spread to other parts of the body."} +{"_id": "6419", "text": "A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs."} +{"_id": "6422", "text": "A bone remodeling disease that results_in abnormal elevated bone density or mass."} +{"_id": "6425", "text": "A Parkinson's disease caused by homozygous or compound heterozygous mutation in the DJ1 gene on chromosome 1p36."} +{"_id": "6428", "text": "A pyloric stenosis characterized by the enlargement of the muscle surrounding the pylorus, causing severe projectile non-bilious vomiting."} +{"_id": "6431", "text": "A bovine respiratory disease complex defined as an acute, noncontagious respiratory distress caused 5-10days after change to a better, often lush, pasture. Metabolites of the naturally occurring amino acid L-tryptophan probably are responsible for the disease. Severely affected cattle show extensive respiratory distress with mouth breathing, extension of the tongue, and drooling. There is extensive edema and emphysema, often with the formation of large air-filled bullae in interlobular and subpleural regions of the lung."} +{"_id": "6434", "text": "A tooth disease characterized by failure to develop on or more missing teeth."} +{"_id": "6437", "text": "An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system."} +{"_id": "6440", "text": "A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus."} +{"_id": "6443", "text": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety."} +{"_id": "6446", "text": "An agnosia that is a loss of the ability to perceive and process pain."} +{"_id": "6449", "text": "A neuropathy that is located_in nerves of the peripheral nervous system."} +{"_id": "6452", "text": "A large intestine cancer that is located_in the colon and/or located_in the rectum."} +{"_id": "6455", "text": "An organ system benign neoplasm that is located_in the respiratory system which extends from the nasal sinuses to the diaphragm."} +{"_id": "6458", "text": "A cerebellar disease characterized by ataxia originating in the cerebellum."} +{"_id": "6461", "text": "An autosomal recessive disease that is characterized at birth or prenatally by malformations and deformities affecting the majority of the skeleton and other areas of the body with autosomal recessive inheritance of the FGFR2 gene."} +{"_id": "6464", "text": "A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions."} +{"_id": "6467", "text": "A histoplasmosis endocarditis that results_in inflammation located_in endocardium, has_material_basis_in Histoplasma capsulatum var duboisii or has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom murmurs, has_symptom peripheral edema, has_symptom pulmonary rales, has_symptom petechia and has_symptom skin lesions."} +{"_id": "6470", "text": "A pancreatic cancer that is located_in the pancreatic islet cells."} +{"_id": "6473", "text": "A sarcoma and malignant neoplasm of penis that is located_in the penis."} +{"_id": "6476", "text": "A commensal Clostridium infectious disease that is caused by ingestion of food contaminated with Clostridium perfringens, which produces an enterotoxin that acts on the small intestine. The symptoms include watery diarrhea, abdominal cramps, a severe decrease in blood pressure and abdominal expansion from gas."} +{"_id": "6479", "text": "A candidiasis that involves fungal infection of the meninges caused by Candida species, predominantly in low birth weight neonates with septicemia, resulting in formation of abscesses."} +{"_id": "6482", "text": "A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers."} +{"_id": "6485", "text": "A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting."} +{"_id": "6488", "text": "An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents."} +{"_id": "6491", "text": "A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis."} +{"_id": "6494", "text": "Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine."} +{"_id": "6497", "text": "An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood."} +{"_id": "6500", "text": "An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body."} +{"_id": "6503", "text": "A retinal disease that is characterized by the loss of cone cells, the photoreceptors responsible for both central and color vision."} +{"_id": "6506", "text": "A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues."} +{"_id": "6509", "text": "A tularemia that is located_in lungs. The bacteria are transmitted_by breathing dusts or aerosols containing the organisms. The infection has_symptom cough, has_symptom chest has_symptom pain, and has_symptom difficulty breathing."} +{"_id": "6512", "text": "An endocrine system disease that is located_in the pituitary gland."} +{"_id": "6515", "text": "An extrinsic allergic alveolitis caused by inhalation of antigens from thermophilic actinomycetes species growing in air conditioners and humidifiers. Fungi like Aureobasidium sp and Candida albicans that survive in the contaminated water in humidifiers and air conditioners are also known to cause the disease."} +{"_id": "6518", "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in vulva, has_material_basis_in human papillomavirus (type16 and 18), which cause malignant tumors in squamous epithelium of the vulva."} +{"_id": "6521", "text": "A fundus dystrophy that is characterized by discrete uniform white dots over the entire fundus with greatest density in the midperiphery and no macular involvement."} +{"_id": "6524", "text": "A lysosomal storage disease that involves he accumulation of glycosaminoglycans in the tissues and their excretion in the urine."} +{"_id": "6527", "text": "A colonic disease characterized by the formation and inflammation of diverticula within the colon wall."} +{"_id": "6530", "text": "An autosomal recessive disease that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair."} +{"_id": "6533", "text": "A intestinal disease characterized by the protrusion by part of the intestine though an opening in the abdominal muscles."} +{"_id": "6536", "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which have signet ring appearance."} +{"_id": "6539", "text": "A synostosis that results_in premature fusion located_in skull."} +{"_id": "6542", "text": "A dermatophytosis that results_in fungal skin infection located_in hand, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, has_symptom burning, has_symptom cracking, and has_symptom scaling."} +{"_id": "6545", "text": "A bone structure disease that has_material_basis_in displacement located_in set of vertebrae."} +{"_id": "6548", "text": "A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men."} +{"_id": "6551", "text": "A mitochondrial metabolism disease that is characterized by a deficiency of CoQ10 resulting from reduced biosynthesis."} +{"_id": "6554", "text": "A hypersensitivity reaction type I disease triggered by latex."} +{"_id": "6557", "text": "A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia."} +{"_id": "6560", "text": "A syndrome characterized by malformations of the outer, middle and inner ear and branchial and renal malformations. Mutations of the EYA1, SIX1 and SIX5 genes are associated with the syndrome."} +{"_id": "6563", "text": "A mite infestation that involves rash caused by Leptotrombidium deliense."} +{"_id": "6566", "text": "An autosomal dominant disease that is characterized by low birth weight and growth retardation, bilateral branchial clefts."} +{"_id": "6569", "text": "A Rubella virus infectious disease that results_in infection located_in joint, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom joint pains."} +{"_id": "6572", "text": "A respiratory system cancer that is located_in the lung."} +{"_id": "6575", "text": "A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people."} +{"_id": "6578", "text": "A parasitic helminthiasis infectious disease that involves infection by parasitic flatworms known as tapeworms living in the vertebrate digestive tract."} +{"_id": "6581", "text": "A viral infectious disease that results_in inflammation located_in lung, has_material_basis_in Influenza A virus, has_material_basis_in Influenza B virus, or has_material_basis_in Influenza C virus, which can directly damage the respiratory epithelium, allowing free access to invading bacteria. The mucous membranes are covered with foamy, bloody fluid from the pulmonary edema in the more acute cases. Interstitial fibrosis has been observed. The infection has_symptom cough, has_symptom pain in the chest and throughout body, has_symptom headache, has_symptom weakness, and has_symptom chills."} +{"_id": "6584", "text": "A leiomyosarcoma and sarcoma of kidney that is located_in the kidney."} +{"_id": "6587", "text": "An extrinsic allergic alveolitis which is caused by inhalation of antigens from avian excreta. The disease has_symptom abrupt onset of dyspnea, has_symptom cough, has_symptom malaise, and has_symptom fever, after exposure to antigen."} +{"_id": "6590", "text": "A perichondritis of auricle with a sudden onset and a short course."} +{"_id": "6593", "text": "A pneumothorax in which air enters into the pleural cavity."} +{"_id": "6596", "text": "A vascular disease that is characterized by generalized calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall."} +{"_id": "6599", "text": "A collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen."} +{"_id": "6602", "text": "A parasitic infectious disease that occurs when part of the body is infested with parasitic worms such as cestodes, nematodes and trematodes."} +{"_id": "6605", "text": "A papillomavirus infectious disease that results_in infection, has_material_basis_in human papillomavirus (types 16, 18, 31, 32 or 33), which cause intraepithelial lesions that may progress to carcinomas."} +{"_id": "6608", "text": "A dengue disease that results_in infection, has_material_basis_in Dengue virus with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has no manifestations of symptoms."} +{"_id": "6611", "text": "An autosomal dominant disease characterized by multiple noncancerous, tumor-like growths (hamartomas) and an increased risk of certain forms of cancer, especially breast, thyroid and endometrium. It is caused by mutations in the PTEN, SDHB, SDHD and KLLN genes."} +{"_id": "6614", "text": "An autosomal recessive disease characterized by intrauterine growth retardation and postnatal dwarfism with microcephaly and intellectual disability."} +{"_id": "6617", "text": "A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding."} +{"_id": "6620", "text": "A substance abuse that involves the recurring use of amphetamines despite negative consequences."} +{"_id": "6623", "text": "A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping."} +{"_id": "6626", "text": "An urticaria induced by sweating."} +{"_id": "6629", "text": "A Kaposi's sarcoma that derives_from the tissue that lines the lymph vessels under the skin or in mucous membranes."} +{"_id": "6632", "text": "An autosomal recessive disorder characterized by severe intrauterine and postnatal growth retardation, microcephaly, bilateral microtia and hypoplastic patellae."} +{"_id": "6635", "text": "An ornithosis involving Chlamydophila psittaci infection, contracted by inhaling dust from the feathers or the waste of infected birds. The symptoms include fever, chills, fatigue, and loss of appetite. A cough develops, which is initially dry but later brings up greenish sputum."} +{"_id": "6638", "text": "A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves."} +{"_id": "6641", "text": "An agnosia that is a loss of the ability to rely on visual cues to guide them directionally due to the inability to recognise objects."} +{"_id": "6644", "text": "A cerebrum cancer that is located_in the parietal lobe."} +{"_id": "6647", "text": "A commensal Alcaligenaceae infectious disease that is caused by the bacterium Bordetella pertussis resulting in difficulty breathing."} +{"_id": "6650", "text": "A Flavivirus infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by mosquito bites. The infection has_symptom fever, has_symptom severe headache, has_symptom back pain, has_symptom muscle ache, has_symptom nausea, and has_symptom weakness."} +{"_id": "6653", "text": "An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor."} +{"_id": "6656", "text": "An endothrix infectious disease that results_in anthropophilic fungal infection located_in skin, located_in nail, located_in beard, and located_in scalp, has_material_basis_in Trichophyton violaceum and results_in_formation_of scaling lesions. The hairs become notably fragile and break easily at the level of the scalp. The rest of the infected follicle looks like \\black dots\\\".\""} +{"_id": "6659", "text": "A parasitic protozoa infectious disease that involves infection caused by fornicates, which are unicellular flagellates with one or two karyomastigonts per cell."} +{"_id": "6662", "text": "A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Trichosporon beigelii. Infected hairs develop soft greyish-white nodules along the shaft."} +{"_id": "6665", "text": "An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism."} +{"_id": "6668", "text": "An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow."} +{"_id": "6671", "text": "A breast carcinoma that is manifested in the female breast."} +{"_id": "6674", "text": "A macrocytic anemia that is characterized by inhibition of DNA synthesis during red blood cell production."} +{"_id": "6677", "text": "A yaws that appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis."} +{"_id": "6680", "text": "A spindle intraocular melanoma that is located_in the ciliary body."} +{"_id": "6683", "text": "A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by Plasmodium species."} +{"_id": "6686", "text": "A leprosy that is an early form of the disease which causes one to a few hypopigmented or erythematous macules."} +{"_id": "6689", "text": "A mouth disease characterized by a white patch on the side of the tongue with a corrugated or hairy appearance; caused by Epstein-Barr virus."} +{"_id": "6692", "text": "A syndrome that is characterized by delayed psychomotor development, visual impairment, and short stature and has_material_basis_in homozygous mutation in the PLK4 gene."} +{"_id": "6695", "text": "A biliary tract cancer that is located_in the bile duct."} +{"_id": "6698", "text": "A urinary system disease that is located_in the lower urinary tract and is characterized by the formation of a stone."} +{"_id": "6701", "text": "An agnosia that is a loss of the ability to recognize musical notes, rhythms, and intervals."} +{"_id": "6704", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the eyes by Philophthalmus species. External ocular philophthalmiasis manifests as follicular conjunctivitis and superficial keratitis. Sub-conjunctival ocular philophthalmiasis consists of a mild edema with minimal cellular reaction."} +{"_id": "6707", "text": "A parasitic protozoa infectious disease that involves infection caused by alveolates, which are single-celled eukaryotes."} +{"_id": "6710", "text": "A skin disease characterized by skin that is loose, hanging, wrinkled and lacking in elasticity; it can also affect connective tissue in other parts of the body, including the heart, blood vessels, joints, intestines and lungs."} +{"_id": "6713", "text": "A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development."} +{"_id": "6716", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis."} +{"_id": "6719", "text": "A viral infectious disease that results_in infection in sheep and goats, has_material_basis_in Border disease virus, which is transmitted_by congenital method. The infection has_symptom abortion, has_symptom stillbirth, has_symptom hairy fleece in lambs, and has_symptom abnormal body conformation."} +{"_id": "6722", "text": "A capillariasis that involves infection of the lungs with Capillaria, resulting in fever, cough, asthma, and pneumonia."} +{"_id": "6725", "text": "An eye disease characterized by variable iris atrophy, pigmented and pedunculated nodules located_in iris and attachment of the iris to the cornea (peripheral anterior synechiae) and characterized_by glaucoma."} +{"_id": "6728", "text": "A lung disease characterized by microbial infection which causes a type of liquefactive necrosis of the pulmonary tissue and formation of cavities containing necrotic debris or fluid."} +{"_id": "6731", "text": "A mesenchymal cell neoplasm that has_material_basis_in myofibroblastic cells admixed with inflammatory cells."} +{"_id": "6734", "text": "A sarcoma and hematologic cancer that derives_from follicular lymphoma."} +{"_id": "6737", "text": "A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma."} +{"_id": "6740", "text": "A Trichomonas vaginalis trichomoniasis that involves inflammation of the vagina caused by Trichomonas vaginalis. The symptoms include foul vaginal odor, burning during urination, vaginal discharge and irritation of the genital area."} +{"_id": "6743", "text": "A filariasis that involves parasitic infection by the nematodes Mansonella ozzardi or Mansonella perstans, which reside in the skin or body cavities. The nematode is transmitted through the bite of midges and blackflies."} +{"_id": "6746", "text": "A dermatomycosis that results_in fungal infection located_in hand, foot and nail of toe by Scytalidium hyalinum, resulting_in_formation_of lesions and has_symptom keratotic plantar surface."} +{"_id": "6749", "text": "A severe combined immunodeficiency that is an autosomal recessive disease with T and B lymphocyte dysfunction, due to a large deletion at one allelle and a point mutation at the other. The point mutation resulted in the alteration of intervening sequence 13 donor splice site. The population of T lymphocytes is diminished and unresponsive to mitogen stimulation. The level of B lymphocyte numbers, serum immunoglobulin decreased with age."} +{"_id": "6752", "text": "A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites."} +{"_id": "6755", "text": "A labyrinthitis which is an infectious inflammatory disease of a circumscribed area of either the vestibular or the cochlear portion of the labyrinth, or of both together. This is caused by a chronic suppurative otitis media, mastoiditis, or cholesteatoma."} +{"_id": "6758", "text": "An ancylostomiasis that involves parasitic infection of the small intestine in humans, cats and dogs by the nematode Ancylostoma duodenale. The symptoms include abdominal pain, loss of appetite, geophagy and anemia."} +{"_id": "6761", "text": "An angiostrongyliasis that involves infection of the brain by the larvae of Angiostrongylus cantonensis causing eosinophilic meningitis. The symptoms include severe headache, nausea, vomiting, neck stiffness, seizures, and neurologic abnormalities. Ocular invasion by the larvae can occur."} +{"_id": "6764", "text": "A mitochondrial metabolism disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction."} +{"_id": "6767", "text": "An urinary tract cancer that derives_from the tissues of the urethra."} +{"_id": "6770", "text": "A fruit allergy triggered by Citrus sinensis plant fruit food product."} +{"_id": "6773", "text": "Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products."} +{"_id": "6776", "text": "A cystitis characterized by a sudden onset or severe symptoms."} +{"_id": "6779", "text": "A disease of mental health that affects cognitive functions including memory processing, perception and problem solving."} +{"_id": "6782", "text": "A lymphoma that is characterized by having cellular features of both classic Hodgkin's lymphomas and large B-cell Lymphomas."} +{"_id": "6785", "text": "A benign neoplasm that is classified by the type of cell or tissue from which it is derived."} +{"_id": "6788", "text": "A histiocytosis that is characterized by clonal proliferation of Langerhans cells."} +{"_id": "6791", "text": "A gastroenteritis that involves inflammation of the stomach and intestines caused by bacteria. The symptoms include abdominal cramps and pain, diarrhea, loss of appetite, nausea, and vomiting."} +{"_id": "6794", "text": "A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing."} +{"_id": "6797", "text": "An eyelid disease that is characterized by often chronic inflammation of the eyelid, generally the part where eyelashes grow."} +{"_id": "6800", "text": "A candidiasis that involves inflammation of the lung caused by Candida species either by hematogenous dissemination or by bronchial extension in patients with oropharyngeal candidiasis. The symptoms include fever, tachypnea, dyspnea, and chest pain."} +{"_id": "6803", "text": "An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra."} +{"_id": "6806", "text": "A dysostosis that is characterized by premature joint ankylosis and has_material_basis_in autosomal dominant inhertitance."} +{"_id": "6809", "text": "An ovarian cancer that has_material_basis_in melanoctyes."} +{"_id": "6812", "text": "An adenoma that is located_in the pancreas and is characterized by overproduction of insulin."} +{"_id": "6815", "text": "A pigmentation disease characterized by lesions that initially arise as letiginous, hyperpigmented macules in a reticular pattern on the dorsal aspect of the hands and feet. Over time, lesions may spread proximally and may darken; palmoplantar pitting and dermatoglyphic disruption may also be present."} +{"_id": "6818", "text": "A viral infectious disease that results_in infection in swine, has_material_basis_in Classical swine fever virus, which is transmitted_by direct contact with oronasal secretions of the infected pig, transmitted_by ingestion of contaminated food, and transmitted_by fomites. The infection has_symptom high fever, has_symptom huddling, has_symptom weakness, has_symptom drowsiness, has_symptom anorexia, has_symptom conjunctivitis, has_symptom diarrhea, and has_symptom hemorrhages in the skin."} +{"_id": "6821", "text": "A lung combined type small cell carcinoma that has_material_basis_in epithelial tissue of glandular origin."} +{"_id": "6824", "text": "A thoracic cancer that is located_in the mediastinum."} +{"_id": "6827", "text": "A disease of anatomical entity that is located_in the immune system."} +{"_id": "6830", "text": "A viral infectious disease that results_in pain located_in trigeminal nerve, has_material_basis_in Human herpesvirus 3, which reactivates after the initial infection. The infection has_symptom facial pain."} +{"_id": "6833", "text": "A spondyloepimetaphyseal dysplasia that is characterized by short stature of prenatal onset, joint dislocations (knees, hips, radial heads), club feet, and limitation of range of motion that can involve all large joints."} +{"_id": "6836", "text": "A pancreatic carcinoma located_in the pancreatic duct."} +{"_id": "6839", "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme beta-glucuronidase resulting in the inability to degrade glucuronic acid-containing glycosaminoglycans."} +{"_id": "6842", "text": "A jejunal cancer that is located_in the jejunum and has_material_basis_in epithelial tissue that has glandular origin."} +{"_id": "6845", "text": "A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system."} +{"_id": "6848", "text": "A viral infectious disease that results_in infection, has_material_basis_in Measles virus, which is transmitted_by droplet spread, or trasnmitted_by contact of oronasal secretions from an infected person."} +{"_id": "6851", "text": "A non-Hodgkin lymphoma involving aberrant T-cells."} +{"_id": "6854", "text": "An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope."} +{"_id": "6857", "text": "A carcinoma in situ that is characterized by the spread of cancer in the eye and the lack of invasion of surrounding tissues."} +{"_id": "6860", "text": "A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition."} +{"_id": "6863", "text": "A leukemia that derives_from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers."} +{"_id": "6866", "text": "A large intestine cancer that is located_in the cecum."} +{"_id": "6869", "text": "A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness."} +{"_id": "6872", "text": "A spotted fever that has_material_basis_in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities."} +{"_id": "6875", "text": "A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen."} +{"_id": "6878", "text": "A sebaceous gland disease characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring."} +{"_id": "6881", "text": "A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone."} +{"_id": "6884", "text": "A pericardial effusion in which fluid accumulates in the pericardium (the sac in which the heart is enclosed) and the pericardial spaces fills up faster than the pericardial sac can stretch."} +{"_id": "6887", "text": "A milk allergy triggered by Bos taurus milk."} +{"_id": "6890", "text": "An ischemic bone disease that results_in necrosis located_in epiphysis."} +{"_id": "6893", "text": "A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms."} +{"_id": "6896", "text": "An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size."} +{"_id": "6899", "text": "An urogenital tuberculosis that results_in inflammtion located_in ovary."} +{"_id": "6902", "text": "A hypersensitivity reaction type II disease that is characterized by glomerulonephritis located_in kidney and hemorrhaging located_in lung."} +{"_id": "6905", "text": "A bone cancer and lymphoma by site that results_in lymphoma starting in the bone."} +{"_id": "6908", "text": "An islet cell tumor that has_material_basis_in epithelial cells."} +{"_id": "6911", "text": "A germ cell cancer that is derived_from a mixture of germs cells and embryonal cells."} +{"_id": "6914", "text": "A typhus that has_material_basis_in Rickettsia prowazekii, which is transmitted_by human body louse (Pediculus humanus corporis). The infection has_symptom high fever, has_symptom cough, has_symptom rash, has_symptom severe muscle pain, has_symptom chills, has_symptom falling blood pressure, has_symptom stupor, has_symptom sensitivity to light, and has_symptom delirium."} +{"_id": "6917", "text": "A viral infectious disease that results_in infection in ruminants, has_material_basis_in Peste-des-petits-ruminants virus, which is transmitted_by contact with oronasal and ocular secretions, urine, and feces. The infection results_in_formation_of lesions on the gums, lips and palate."} +{"_id": "6920", "text": "A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back."} +{"_id": "6923", "text": "An agnosia that is a loss of the ability to recognize visual scenes or classes of objects but retain the abilty to describe them."} +{"_id": "6926", "text": "An inherited metabolic disorders which impair the synthesis and degradation of amino acids."} +{"_id": "6929", "text": "A spastic cerebral palsy that affects all four limbs. The individuals have difficulty with walking and talking."} +{"_id": "6932", "text": "An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis."} +{"_id": "6935", "text": "A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell."} +{"_id": "6938", "text": "An esophagitis characterized by inflammation involving eosinophils located_in esophagus."} +{"_id": "6941", "text": "A Salmonella infectious disease that is caused by Gram-negative bacteria of genus Salmonella which is rare in adults, although more common in children in the tropics. This infection is complicated by suppuration with lung abscess or empyema formation."} +{"_id": "6944", "text": "An alveolar soft part sarcoma that recurs over time."} +{"_id": "6947", "text": "A peroxisomal disease that is characterized by hypotonia and seizures in the neonatal period and neurological regression in early infancy."} +{"_id": "6950", "text": "A commensal streptococcal infectious disease that is caused by group B streptococci (Streptococcus agalactiae) usually infecting neonates and the elderly."} +{"_id": "6953", "text": "A Nidovirales infectious disease that results_in infection in animals and humans, has_material_basis_in Coronaviridae viruses, which is transmitted_by droplet spread of respiratory secretions or transmitted_by ingestion of contaminated food."} +{"_id": "6956", "text": "A trichostrongyloidiasis that involves parasitic infection of the ruminant gastrointestinal tract by nematodes of the genus Ostertagia."} +{"_id": "6959", "text": "A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation."} +{"_id": "6962", "text": "A syndrome that is characterized by congenital microcephaly and chorioretinal dysplasia associated with poor vision and nystagmus and has_material_basis_in compound heterozygous mutation in the TUBGCP4 gene."} +{"_id": "6965", "text": "A cystits which involves inflammation and formation of a dense fibrous false membrane on the mucous membrane of the bladder."} +{"_id": "6968", "text": "A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow."} +{"_id": "6971", "text": "A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver."} +{"_id": "6974", "text": "An organ system cancer that is located in the peritoneum."} +{"_id": "6977", "text": "A connective tissue cancer that has_material_basis_in cells derived from transformed cells that produce cartilage."} +{"_id": "6980", "text": "A (-)ssRNA virus infectious disease that results_in infection located_in liver in humans, has_material_basis_in Deltavirus."} +{"_id": "6983", "text": "A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells."} +{"_id": "6986", "text": "A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes."} +{"_id": "6989", "text": "An American histoplasmosis that results_in inflammation located_in lung, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom mediastinal lymphadenopathy, has_symptom cough and has_symptom chest pain."} +{"_id": "6992", "text": "An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions."} +{"_id": "6995", "text": "A tuberculosis that involves infection of the mesenteric glands by tuberculosis causing mycobacteria. The symptoms include distended abdomen, persistent intestinal indigestion, diarrhea, flatulence, and abdominal pain."} +{"_id": "6998", "text": "An immune system disease that is related to the transplantation of cells, tissues and/or whole organs from one individual to another."} +{"_id": "7001", "text": "An ectothrix infectious disease that results_in non-inflammatory fungal infection located_in scalp and located_in skin, has_material_basis_in Microsporum audouinii."} +{"_id": "7004", "text": "A tracheal cancer that effects the airway that leads from the larynx to the bronchi."} +{"_id": "7007", "text": "A coagulation protein disease that is a hereditary abnormality which slows the blood clotting process. It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion."} +{"_id": "7010", "text": "An acquired immunodeficiency syndrome that results_in infection located_in brain, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom cognitive impairment, has_symptom motor dysfunction, and has_symptom behavioral change."} +{"_id": "7013", "text": "A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash."} +{"_id": "7016", "text": "A tuberculosis that is resistant to isoniazid and rifampicin, the two most powerful first-line anti-TB drugs."} +{"_id": "7019", "text": "A viral infectious disease that results_in infection in cattle, has_material_basis_in Bovine viral diarrhea virus 2, which is transmitted_by ingestion of infected food, or transmitted_by nasal secretions. The infection has_symptom low grade fever, has_symptom bloody diarrhea, and has_symptom bleeding in the eyes."} +{"_id": "7022", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection in dogs, cats and humans caused by cysticercoid larvae of Dipylidium caninum through ingestion of larvae contaminated flea, which results in diarrhea and restlessness."} +{"_id": "7025", "text": "An endothrix infectious disease that results_in anthropophilic fungal infection located_in skin, located_in nail and located_in scalp, has_material_basis_in Trichophyton tonsurans and results_in_formation_of scaling lesions."} +{"_id": "7028", "text": "A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction."} +{"_id": "7031", "text": "A genital herpes that results_in infection located_in skin of vulva, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2 and has_symptom lesions."} +{"_id": "7034", "text": "A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection."} +{"_id": "7037", "text": "An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness."} +{"_id": "7040", "text": "An impulse control disorder that involves the repeated impulse to steal for no great gain, when he or she has sufficient money to pay for the item and no need for what is stolen."} +{"_id": "7043", "text": "An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood."} +{"_id": "7046", "text": "A duodenal benign neoplasm that has_material_basis_in epithelial tissue with glandular origin."} +{"_id": "7049", "text": "An urticaria induced by external physical influences."} +{"_id": "7052", "text": "A Salmonella infectious disease that involves infection of the intestine caused by Salmonella enterica subsp arizonae, which is a gut inhabitant of reptiles. The symptoms include fever, headache, abdominal pain, vomiting, and diarrhea."} +{"_id": "7055", "text": "An endocrine system disease that is located_in the adrenal gland."} +{"_id": "7058", "text": "An amino acid metabolic disorder that involves defective proteins called carnitine transporters, which bring carnitine into cells and prevent its escape from the body preventing the body cannot utilize fats for energy."} +{"_id": "7061", "text": "A vascular disease that is characterized by compression at the superior thoracic outlet resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles."} +{"_id": "7064", "text": "A nasal cavity carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "7067", "text": "A type of ALS caused_by mutation located_in OPTN gene located_in chromosome 10."} +{"_id": "7070", "text": "A malaria caused by a parasite Plasmodium malariae, which is marked by recurrence of paroxysms at 72-hour intervals."} +{"_id": "7073", "text": "An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing."} +{"_id": "7076", "text": "A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis."} +{"_id": "7079", "text": "An alopecia areata that involves diffuse loss of hair over the whole scalp."} +{"_id": "7082", "text": "A syndrome that is characterized by the presence of at least three of the following: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities."} +{"_id": "7085", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness."} +{"_id": "7088", "text": "An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash."} +{"_id": "7091", "text": "A spinal chordoma that is located_in the sacrum."} +{"_id": "7094", "text": "An extrapulmonary tuberculosis that results in formation of tuberculomas located_in brain or located_in spinal cord."} +{"_id": "7097", "text": "A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas."} +{"_id": "7100", "text": "A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern."} +{"_id": "7103", "text": "A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload."} +{"_id": "7106", "text": "A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy."} +{"_id": "7109", "text": "A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis."} +{"_id": "7112", "text": "A synostosis characterized by the fusion of carpal and tarsal bones, which causes stiffness and immobility of the hands and the feet."} +{"_id": "7115", "text": "A Strongylida infectious disease that involves infection of the small intestine of mammals, cats and dogs by the parasitic nematodes of genus Ancylostoma, Necator and Uncinaria."} +{"_id": "7118", "text": "A liver cancer that has_material_basis_in epithelial cells."} +{"_id": "7121", "text": "A cutaneous mycosis that results_in fungal infection located_in skin, located_in hair, and located_in nail, has_material_basis_in Epidermophyton, has_material_basis_in Microsporum, or has_material_basis_in Trichophyton, which invade the dead keratin and has_symptom itchy patches, and has_symptom red rash on the skin."} +{"_id": "7124", "text": "A pollen allergy triggered by Phleum pratense pollen."} +{"_id": "7127", "text": "A rhabdomyosarcoma wherein the mesenchymally-derived malignant cells resemble the primitive developing skeletal muscle of the embryo; it occurs most often in the head and neck area or in the genital or urinary organs."} +{"_id": "7130", "text": "A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Myodes glareolus . The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure."} +{"_id": "7133", "text": "An adenoma that is composed_of cells with a clear cytoplasm located_in ovary."} +{"_id": "7136", "text": "A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs."} +{"_id": "7139", "text": "A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia."} +{"_id": "7142", "text": "A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood."} +{"_id": "7145", "text": "An autosomal dominant disease characterized by variable combinations of microcephaly, limb malformations, esophageal and duodenal atresias, and learning disability/mental retardation."} +{"_id": "7148", "text": "A lymphocytic choriomeningitis that results_in inflammation located_in meninges and located_in brain, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom headache, has_symptom stiff neck, has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis."} +{"_id": "7151", "text": "An adenosarcoma and malignant uterine body mixed neoplasm that derives_from the glands that line the uterus."} +{"_id": "7154", "text": "A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source."} +{"_id": "7157", "text": "A prostate cancer that is located_in the prostate."} +{"_id": "7160", "text": "A primary systemic mycosis that results_in fungal infection located_in human body, has_material_basis_in Ascomycota phylum members."} +{"_id": "7163", "text": "A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability."} +{"_id": "7166", "text": "A prostate sarcoma that is located_in the prostate."} +{"_id": "7169", "text": "An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone."} +{"_id": "7172", "text": "A carbohydrate metabolism disorder that is characterized by abnormal accumulation or depletion of liver glycogen."} +{"_id": "7175", "text": "A Parabasalia infectious disease that involves infection with anaerobic flagellate parasites belonging to the order Tritrichomonadida, which are characterized by a single mastigont with four flagella, and both a comb-like structure and an infrakinetosomal body."} +{"_id": "7178", "text": "A medical disorder that is an illness caused by abnormalities in genes or chromosomes."} +{"_id": "7181", "text": "An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes."} +{"_id": "7184", "text": "A small intestine cancer that develops from epithelial cells and is located_in the small intestine."} +{"_id": "7187", "text": "A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure."} +{"_id": "7190", "text": "A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis."} +{"_id": "7193", "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis."} +{"_id": "7196", "text": "An osteochondrodysplasia characterized by generalized platyspondyly without significant long bone abnormalities and short stature."} +{"_id": "7199", "text": "A tularemia that results in formation of ulcerative lesions located_in gastrointestinal tract. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom muscle aches, and has_symptom vomiting."} +{"_id": "7202", "text": "A parasitic helminthiasis infectious disease that involves intestinal infection by the parasite of the genus Heterophyes. The symptoms are diarrhea and colicky abdominal pain. Migration of the eggs to the heart, results in fatal myocardial and valvular damage. Brain can also be infected."} +{"_id": "7205", "text": "A female reproductive organ cancer that is located_in the uterus."} +{"_id": "7208", "text": "A malignant neoplasm that derives_from the retina."} +{"_id": "7211", "text": "An organ system cancer that is manifested in the reproductive organs."} +{"_id": "7214", "text": "A neurodegenerative disease that is characterized by onset between ages 2 and 6 months of truncal hypotonia, athetosis, seizures, and ophthalmologic abnormalities, particularly optic atrophy and retinal degeneration."} +{"_id": "7217", "text": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes."} +{"_id": "7220", "text": "A viral infectious disease that results_in inflammation located_in intestine of turkeys, has_material_basis_in Turkey coronavirus, which is transmitted_by ingestion of food contaminated with feces, or transmitted_by fomites contaminated with feces. The infection has_symptom diarrhea, has_symptom anorexia, has_symptom decreased weight, and has_symptom depression."} +{"_id": "7223", "text": "A blepharitis that is characterized as a cyst in the eyelid that is caused by inflammation of a blocked meibomian gland, usually on the upper eyelid."} +{"_id": "7226", "text": "A small intestine cancer that is located_in the ileum."} +{"_id": "7229", "text": "A venous insufficiency that is characterized by aching pain, heaviness, swelling, cramps, itching, or tingling in the affected limb and is a chronic complication of deep venous thrombosis."} +{"_id": "7232", "text": "A germ cell and embryonal cancer that derives_from trophoblastic tissue."} +{"_id": "7235", "text": "An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland."} +{"_id": "7238", "text": "A syndrome that is characterized by delayed psychomotor development and visual impairment, often accompanied by short stature and has_material_basis_in homozygous or compound heterozygous mutation in the TUBGCP6 gene."} +{"_id": "7241", "text": "A vitamin B12 deficiency that is characterized by a lack of vitamin B12 intestinal absorption resulting from a deficiency in the B12 transport protein TCII."} +{"_id": "7244", "text": "A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities."} +{"_id": "7247", "text": "A nervous system benign neoplasm that is characterized as a nerve tissue tumor."} +{"_id": "7250", "text": "A parasitic protozoa infectious disease that involves infection caused by the members of the class Heterolobosea, which move with eruptive bulges and show transformation to a temporary flagellate stage."} +{"_id": "7253", "text": "An adenoma that derives_from epithelial cells which have clear cytoplasm."} +{"_id": "7256", "text": "A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment."} +{"_id": "7259", "text": "A peripheral nervous system neoplasm that is located_in the autonomic nervous system."} +{"_id": "7262", "text": "An autonomic nervous system neoplasm that derives_from immature nerve cells."} +{"_id": "7265", "text": "A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra."} +{"_id": "7268", "text": "A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm."} +{"_id": "7271", "text": "An anxiety disorder that has_symptom flashbacks, has_symptom bad dreams, has_symptom frightening thoughts, has_symptom avoidance or has_symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD."} +{"_id": "7274", "text": "A large intestine cancer that is located_in the terminal part of the large intestine."} +{"_id": "7277", "text": "A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord."} +{"_id": "7280", "text": "A cardiovascular system disease that is located_in the fibrous sac surrounding the heart."} +{"_id": "7283", "text": "A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton concentricum, which is characterized by ring-like growth in overlapping circles that may have an autosomal dominant genetic predisposition."} +{"_id": "7286", "text": "A Measles virus infectious disease that results_in inflammation located_in middle ear, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom pain in the ear."} +{"_id": "7289", "text": "A fruit allergy triggered by Prunus persica plant fruit food product."} +{"_id": "7292", "text": "An endocrine gland cancer located_in the parathyroid glands located in the neck."} +{"_id": "7295", "text": "An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system."} +{"_id": "7298", "text": "A skin disease where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion."} +{"_id": "7301", "text": "A hypersensitivity vasculitis that results_in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin."} +{"_id": "7304", "text": "An ovarian carcinoma that has_material_basis_in cells with clear cytoplasm and glycogen secreting hob nail cells."} +{"_id": "7307", "text": "A nasal cavity cancer that_has_material_basis_in epithelial cells."} +{"_id": "7310", "text": "A substance abuse that involves the recurring use of cannabis despite negative consequences."} +{"_id": "7313", "text": "A bullous skin disease characterized by skin lesions and scaring and located_in mucous membranes and located_in skin."} +{"_id": "7316", "text": "An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint."} +{"_id": "7319", "text": "A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media."} +{"_id": "7322", "text": "An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle."} +{"_id": "7325", "text": "A Herpesviridae infectious disease that results_in infection, has_material_basis_in Human herpesvirus 8."} +{"_id": "7328", "text": "A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement."} +{"_id": "7331", "text": "A methylmalonic acidemia that has_material_basis_in deficiency in synthesis of both AdoCbl and MeCbl (cblC) and is characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl), which results in decreased activity of the respective enzymes methylmalonyl-CoA mutase."} +{"_id": "7334", "text": "A chordoma of skull base that is located in the clivus."} +{"_id": "7337", "text": "A skin carcinoma that has_material_basis_in squamous cells."} +{"_id": "7340", "text": "A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly."} +{"_id": "7343", "text": "A non-suppurative otitis media which is a collection of fluid that occurs in the middle ear space as a result of the negative pressure produced by altered Eustachian tube function. This can occur from viral upper respiratory infection or bacterial infection, or it can precede and/or follow acute bacterial otitis media."} +{"_id": "7346", "text": "A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face."} +{"_id": "7349", "text": "A toxoplasmosis that involves inflammation of the liver caused by the protozoan Toxoplasma gondii, which results in jaundice."} +{"_id": "7352", "text": "A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work."} +{"_id": "7355", "text": "A candidiasis that involves infection of the small intestine caused by Candida species, resulting in ulceration."} +{"_id": "7358", "text": "A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea."} +{"_id": "7361", "text": "A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system."} +{"_id": "7364", "text": "A gastrointestinal system disease that is located_in the gallbladder."} +{"_id": "7367", "text": "An iron metabolism disease that has_material_basis_in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload."} +{"_id": "7370", "text": "An anus carcinoma that derives_from epithelial cells of glandular origin located_in the anal gland."} +{"_id": "7373", "text": "A primary immunodeficiency disease that is the result in a mutation of a gene encoding one of the thirty complement system proteins, produced predominantly in liver, which function to defend against infection and produce inflammation."} +{"_id": "7376", "text": "A glioblastoma multiforme that is characterized by abnormally high levels of epidermal growth factor receptor and the absence of p53 mutations."} +{"_id": "7379", "text": "An agnosia that is a loss of the ability to recognize or identify objects by touch alone."} +{"_id": "7382", "text": "A coxsackie carditis that results_in inflammation located_in endocardium, has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions."} +{"_id": "7385", "text": "A viral infectious disease that results_in infection in primates and monkeys, has_material_basis_in Simian immunodeficiency virus, which is transmitted_by sexual contact, and transmitted_by ingestion of virus-infected milk. The infection The virus attacks the immune system leading to severe depletion of CD4+ T cells."} +{"_id": "7388", "text": "A brain disease that is characterized by brain damage resulting from the abnormal folding, clumping and accumulation of cellular proteins in the brain induced by prion proteins."} +{"_id": "7391", "text": "A male infertility disease characterized by the absence of any measurable level of sperm in semen."} +{"_id": "7394", "text": "A microcytic anemia characterized by paler than normal blood cells."} +{"_id": "7397", "text": "A Nematoda infectious disease that involves infection by parasitic worms of the class Enoplea, characterized by no body annules, no elaborate amphids, and five or more esophageal glands."} +{"_id": "7400", "text": "A Togaviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Alphavirus, which is transmitted_by mosquito bite."} +{"_id": "7403", "text": "A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Rocio virus, which is transmitted_by Psorophora ferox and transmitted_by Aedes species of mosquitoes. The infection has_symptom abdominal distension, has_symptom confusion, has_symptom motor impairment, has_symptom difficulty in walking and maintaining balance, has_symptom meningeal irritation, and has_symptom cerebellar syndrome."} +{"_id": "7406", "text": "A viral infectious disease that results_in breakdown of red blood cells in horses, has_material_basis_in Equine infectious anemia virus, which is transmitted_by horse fly bite, transmitted_by deer fly bite, transmitted_by contact with saliva, milk, and body secretions, and transmitted_by contaminated needles and surgical equipment. The infection has_symptom anemia, has_symptom weakness, has_symptom swelling of the lower abdomen and legs, has_symptom weak pulse, and has_symptom irregular heartbeat."} +{"_id": "7409", "text": "A B cell deficiency that is an autosomal recessive disorder caused by mutation in the IgA (CD79 alpha) antigen receptor."} +{"_id": "7412", "text": "A respiratory allergy triggered by pollen."} +{"_id": "7415", "text": "A RNA virus infectious disease that results_in infection, has_material_basis_in ssRNA positive-strand viruses, no DNA stage, which possess positive-sense single-stranded RNA genomes."} +{"_id": "7418", "text": "A stomach carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "7421", "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia."} +{"_id": "7424", "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Human astrovirus, which is transmitted_by ingestion of contaminated food. The infection has_symptom watery diarrhea, has_symptom nausea, has_symptom abdominal pain, has_symptom vomiting, and has_symptom fever."} +{"_id": "7427", "text": "A neuromuscular junction disease that is characterized by weakness and easy fatiguability resulting from a genetic defect at the junction where the nerve stimulates muscle activity that result in muscle weakness and may affect nerve cells (presynaptic), muscle cells (postsynaptic) or the space between nerve and muscle cells (synaptic)."} +{"_id": "7430", "text": "An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs."} +{"_id": "7433", "text": "A small intestine cancer that has_material_basis_in cells of the neuroendocrine system."} +{"_id": "7436", "text": "A cecal benign neoplasm that has_material_basis_in epithelial tissue with glandular origin."} +{"_id": "7439", "text": "An adamantinoma that is located_in the long bones and results_in focal epithelial differentiation."} +{"_id": "7442", "text": "A viral infectious disease that results_in inflammation located_in lungs, has_material_basis_in Ovine progressive pneumonia virus, which is transmitted_by droplet spread of oronasal secretion, and transmitted_by ingestion of contaminated milk or colostrum. The infection has_symptom coughing, has_symptom bronchial exudate, has_symptom depression, and has_symptom fever."} +{"_id": "7445", "text": "A cell type benign neoplasm that has_physical_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood."} +{"_id": "7448", "text": "An autosomal dominant disease that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose."} +{"_id": "7451", "text": "A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton."} +{"_id": "7454", "text": "A fruit allergy triggered by Solanum lycopersicum plant fruit food product."} +{"_id": "7457", "text": "A Parkinson's disease caused by mutation in the FBXO7 gene located on chromosome 22q12.3."} +{"_id": "7460", "text": "Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure."} +{"_id": "7463", "text": "A gingival overgrowth characterized by benign, slowly progressive, nonhemorrhagic, fibrous enlargement of the oral masticatory mucosa."} +{"_id": "7466", "text": "An immune system disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the exocrine system."} +{"_id": "7469", "text": "A soft tissue infectious disease that involves accumulation of pus in the pleural cavity as a result of infection within the lung (pneumonia) or a lung abscess spreading into the space. The symptoms include cough, fever, chest pain, sweating and shortness of breath."} +{"_id": "7472", "text": "A trachea carcinoma that is characterized by the presence of squamous cells, mucus-secreting cells, and intermediate cells."} +{"_id": "7475", "text": "An intestinal cancer that is located_in the small intestine."} +{"_id": "7478", "text": "An AIDS-related Kaposi's sarcoma and gastric Kaposi's sarcoma that is located_in the stomach."} +{"_id": "7481", "text": "A bone cancer and jaw disease that is located_in the jaw and results_in a swollen jaw, results_in numbness or a tingling sensation in jaw, and results_in an abnormal growth of the jaw bone."} +{"_id": "7484", "text": "A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache."} +{"_id": "7487", "text": "A prostate rhabdomyosarcoma that is most common in children."} +{"_id": "7490", "text": "A type 2 diabetes that involves severe lipodystrophy in addition to the traditional signs of diabetes."} +{"_id": "7493", "text": "An American histoplasmosis that results_in inflammation located_in meninges, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and results_in_formation_of focal mass lesions, has_symptom headache, has_symptom confusion, has_symptom decreased level of consciousness, has_symptom cranial nerve deficits, and has_symptom seizures."} +{"_id": "7496", "text": "A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex."} +{"_id": "7499", "text": "A pulmonary tuberculosis involving inflammation that causes extensive thickening of the walls of the trachea with luminal narrowing."} +{"_id": "7502", "text": "A sarcoma of colon that is located_in the colon."} +{"_id": "7505", "text": "A bone cancer and neoplasm of chest wall and sternal disorder that is located_in the sternum."} +{"_id": "7508", "text": "An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional."} +{"_id": "7511", "text": "A Chromadorea infectious disease that involves infection by parasitic nematodes of the order Rhabditida, characterized by oral aperture with 2, 3 or 6 lips."} +{"_id": "7514", "text": "A lymphocytic choriomeningitis that results_in inflammation located_in meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom headache, and has_symptom stiff neck."} +{"_id": "7517", "text": "An inherited metabolic disorder resulting from a deficiency in vitamin or vitamin cofactor transport or metabolism."} +{"_id": "7520", "text": "An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system."} +{"_id": "7523", "text": "A male reproductive organ cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is_located_in the Cowper's gland."} +{"_id": "7526", "text": "Hydrops fetalis is a alpha thalassemia characterized by an abnormal accumulation of serous fluid in the fetal tissues, as in erythroblastosis fetalis."} +{"_id": "7529", "text": "An adult sarcoma of soft tissue and myxoid chondrosarcoma that is composed_of multiple lobules of chondroblast-like cells, arranged in cords and strands, embedded in a myxoid stroma, and separated by fibrous septa."} +{"_id": "7532", "text": "A schizophrenia that involves delusions or auditory hallucinations of persecution or being plotted against without thought disorder, disorganized behavior, or affective flattening."} +{"_id": "7535", "text": "An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness."} +{"_id": "7538", "text": "An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands."} +{"_id": "7541", "text": "A speech disorder that involves the automatic repetition of vocalizations made by another person."} +{"_id": "7544", "text": "A muscle tissue disease characterized by muscles unusually sensitive to movement or pressure; the proximal muscles are most affected, especially the thighs."} +{"_id": "7547", "text": "A subcutaneous mycosis that results_in fungal infection located_in skin and located_in subcutaneous tissue, has_material_basis_in Fungi incertae sedis taxon members."} +{"_id": "7550", "text": "A gastritis that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting."} +{"_id": "7553", "text": "A drug dependence that involves the continued use of cannabis despite problems related to use of the substance."} +{"_id": "7556", "text": "An ehrlichiosis that results_in infection located_in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted_by lone start tick (Amblyomma americanum ). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash."} +{"_id": "7559", "text": "A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells."} +{"_id": "7562", "text": "A gonadal dysgenesis that is characterized by the lack of functional ovaries to induce puberty in an otherwise 46,XX female."} +{"_id": "7565", "text": "A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs."} +{"_id": "7568", "text": "A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice."} +{"_id": "7571", "text": "A lipoma that is a deep-seated, firm, yellow tumors that characteristically occur on the legs of women."} +{"_id": "7574", "text": "A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue."} +{"_id": "7577", "text": "An Alveolata infectious disease that involves infection caused by the members of the phylum Ciliophora, which are characterized by the presence of hair-like organelles called cilia."} +{"_id": "7580", "text": "An opportunistic mycosis that results_in fungal infection located_in human body, has_material_basis_in Fungi incertae sedis taxon members."} +{"_id": "7583", "text": "An esophageal carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "7586", "text": "A cervix carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "7589", "text": "A lipoma that is characterized by floret giant cells with overlapping nuclei."} +{"_id": "7592", "text": "An amnestic disorder that involves the impaired or lost ability to memorize new things."} +{"_id": "7595", "text": "A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart."} +{"_id": "7598", "text": "A leukemia that arises from changes in the tissues forming white blood cells and characterized by a normal or decreased number of white blood cells in the circulating blood."} +{"_id": "7601", "text": "An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation."} +{"_id": "7604", "text": "A hereditary ataxia that has_material_basis_in autosomal recessive inheritance."} +{"_id": "7607", "text": "A non-syndromic intellectual disability characterized by an autosomal dominant inheritance pattern."} +{"_id": "7610", "text": "A non-suppurative otitis media that is characterized by effusion with very thick and glue-like middle ear fluid which may cause conductive hearing impairment."} +{"_id": "7613", "text": "A dsDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Herpesviridae viruses."} +{"_id": "7616", "text": "A multiple sclerosis that is characterised by a worsening of disability, rather than by relapses followed by recovery, which progressively worsens until a steady progression of disability replaces the cycles of attacks."} +{"_id": "7619", "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice."} +{"_id": "7622", "text": "An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth."} +{"_id": "7625", "text": "A Mumps virus infectious disease that results_in inflammation located_in liver, has_material_basis_in Mumps virus, which is transmitted_by contact with the oronasal secretions of an infected person. The infection causes swelling of parotid gland and has_symptom fever, has_symptom nausea, has_symptom anorexia, and has_symptom dark urine."} +{"_id": "7628", "text": "A cardiovascular cancer located_in the heart."} +{"_id": "7631", "text": "A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon."} +{"_id": "7634", "text": "A female reproductive system cancer that is located_in the vagina."} +{"_id": "7637", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death."} +{"_id": "7640", "text": "A tooth disease characterized by a localized collection of pus associated with a tooth."} +{"_id": "7643", "text": "A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress."} +{"_id": "7646", "text": "An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas."} +{"_id": "7649", "text": "An astrocytoma that is characterized by cells with regular, round to oval nuclei."} +{"_id": "7652", "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet."} +{"_id": "7655", "text": "A primary syphilis that is characterized by occurence of painless sores on the anus, which is caused by the spirochete Treponema pallidum."} +{"_id": "7658", "text": "A biliary tract neoplasm characterized by multiple papillary tumors in the intrahepatic and/or extrahepatic biliary tree."} +{"_id": "7661", "text": "A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss."} +{"_id": "7664", "text": "A herpes zoster that is complicated_by AIDS."} +{"_id": "7667", "text": "A kidney cancer that is located_in the kidney's connective tissue."} +{"_id": "7670", "text": "A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death."} +{"_id": "7673", "text": "An autosomal dominant cerebellar ataxia that has_material_basis_in expansion of CAG triplet repeats (glutamine) encoding a polyglutamine tract in the atrophin-1 protein."} +{"_id": "7676", "text": "A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy."} +{"_id": "7679", "text": "An amino acid metabolic disorder that involves failures of carboxylation enzymes."} +{"_id": "7682", "text": "A cerebrum cancer that is located_in the cerebral ventricles."} +{"_id": "7685", "text": "An ectothrix infectious disease that results_in geophilic fungal infection located_in glabrous skin, located_in scalp and located_in hair, has_material_basis_in Microsporum gypseum, which results_in_formation_of inflammatory lesions."} +{"_id": "7688", "text": "A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease."} +{"_id": "7691", "text": "A lymph node tuberculosis that is characterized by a peri-hilar or paratracheal lymph adenopathy after the primary infection. The diseased lymph nodes and associated inflammatory edema compress the airways resulting in partial or total airway obstruction. When a caseating lymph node erupts into an airway, aspiration of caseous material results in dense alveolar consolidation of the affected segment/lobe."} +{"_id": "7694", "text": "An auditory system cancer that is located_in the middle ear."} +{"_id": "7697", "text": "A mitochondrial metabolism disease characerized by a highly variable phenotype. Some patients have multisystem involvement of the brain, heart, muscle, liver, and kidneys resulting in death in infancy, whereas others have only isolated cardiac or muscle involvement with onset in adulthood and normal cognition. It s caused by homozygous or compound heterozygous mutation in the nuclear-encoded SDHA gene on chromosome 5p, the nuclear-encoded SDHAF1 gene on chromosome 19q, or the nuclear-encoded SDHD gene on chromosome 11q23."} +{"_id": "7700", "text": "An ovarian cancer that is derived_from ovarian surface epithelium."} +{"_id": "7703", "text": "An autosomal recessive disease that is characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form) resulting from dysfunction of ciliary proteins (ciliopathy)."} +{"_id": "7706", "text": "A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image)."} +{"_id": "7709", "text": "An eosinophilic pneumonia which slowly progresses over weeks to months. Life-threatening shortness of breath can develop if the condition is not treated. Individuals are often diagnosed with asthma before the advent of this disease."} +{"_id": "7712", "text": "A Pseudomonas infectious disease that involves infection of the intestine caused by the bacterial genus Pseudomonas, which can result in diarrhea, necrotizing enterocolitis, typhlitis and rectal abscess."} +{"_id": "7715", "text": "A colitis caused_by diversion of the fecal stream due to complication of ileostomy or colostomy."} +{"_id": "7718", "text": "A communication disorder that involves difficulty with the act of speech production."} +{"_id": "7721", "text": "An intestinal disease that involves intestinal infection caused by viruses, bacteria, fungi and parasites."} +{"_id": "7724", "text": "A pulmonary tuberculosis characterized by tubercles formation which coalesce into consolidated areas. Caseation and softening of these areas, with involvement of the interstitial tissue, lead to the formation of a cavity. The symptoms include fever, increased cough and sputum."} +{"_id": "7727", "text": "An African histoplasmosis that results_in inflammation located_in retina, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and results_in_formation_of lesions."} +{"_id": "7730", "text": "An osteomyelitis that has_material_basis_in infection located_in petrous part of temporal bone."} +{"_id": "7733", "text": "An eating disorder that is characterized by effortless regurgitation of most meals following consumption."} +{"_id": "7736", "text": "A spotted fever that has_material_basis_in Rickettsia sibirica, which is transmitted_by ticks (Dermacentor nuttalli, Dermacentor marginatus and Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash."} +{"_id": "7739", "text": "A colitis characterized by a distinctive thickening of the subepithelial collagen table."} +{"_id": "7742", "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma."} +{"_id": "7745", "text": "A jaw cancer and maxillary disease that effects the maxilla or upper jaw."} +{"_id": "7748", "text": "An autosomal recessive disease that is characterized by microcephaly, intellectual deficit and early onset symptoms of achalasia (abnormal enlargement of the esophagus, impaired peristalsis, cardiospasm, recurrent vomiting and respiratory infections)."} +{"_id": "7751", "text": "A phlebitis that results from a blood clot in the vessel."} +{"_id": "7754", "text": "A Human immunodeficiency virus infectious disease that results_in microvascular changes located_in retina, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom cotton-wool spots, has_symptom retinal hemorrhages, and has_symptom microaneurysms."} +{"_id": "7757", "text": "An autosomal dominant disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium."} +{"_id": "7760", "text": "A physical disorder that is the result of structural, biochemical or electrical abnormalities in the brain or spinal cord, or in the nerves leading to or from them, can result in symptoms such as paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain and altered levels of consciousness."} +{"_id": "7763", "text": "A pervasive developmental disorder that is a rare condition characterized by late onset (>3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress."} +{"_id": "7766", "text": "A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots."} +{"_id": "7769", "text": "An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins."} +{"_id": "7772", "text": "A refractory hematologic cancer that is a mature B cell cancer that does not yield readily to treatment."} +{"_id": "7775", "text": "A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep."} +{"_id": "7778", "text": "A severe acute respiratory syndrome that results_in infection located_in lungs, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom myalgia, has_symptom lethargy, has_symptom cough, has_symptom sore throat, has_symptom shortness of breath, and other breathing difficulties which may lead to death as a result of respiratory failure."} +{"_id": "7781", "text": "A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located_in neuromuscular junction, resulting in descending muscle paralysis, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F."} +{"_id": "7784", "text": "A female reproductive organ cancer that is located_in the cervix."} +{"_id": "7787", "text": "A otitis which involves inflammation of the middle ear."} +{"_id": "7790", "text": "An esophageal carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "7793", "text": "A genital herpes that results_in infection located_in skin of penis, has_material_basis_in Human herpesvirus 1 and Human herpesvirus 2 and has_symptom lesions, and has_symptom swollen glands in the groin area."} +{"_id": "7796", "text": "A Simplexvirus infectious disease that results_in inflammation located_in esophagus, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2. The infection has_symptom difficulty swallowing, has_symptom fever, has_symptom herpetic lesions and has_symptom painful swallowing."} +{"_id": "7799", "text": "A liver disease that is characterized by an accumulation of bile in the liver resulting from a reducted number of liver small bile ducts."} +{"_id": "7802", "text": "A carbohydrate metabolic disorder characterized by the buildup of lactic acid in the body and a variety of neurological problems and caused by a deficiency of one of the three enzymes in the pyruvate dehydrogenase complex."} +{"_id": "7805", "text": "A female reproductive organ cancer that is located_in the ovary."} +{"_id": "7808", "text": "A penis carcinoma that has_material_basis_in squamous cells."} +{"_id": "7811", "text": "An idiopathic interstitial pneumonia which is a distinctive type of chronic fibrosing interstitial pneumonia with thick scarring in the lung creating a honeycomb appearance. The main symptoms start insidiously as shortness of breath on exertion, cough, and diminished stamina. Other common complaints include weight loss and fatigue. The level of oxygen in the blood decreases, and the skin may take on a bluish tinge (called cyanosis) and the ends of the fingers may become thick or club-shape. In most people, symptoms worsen over a period ranging from about 6 months to several years."} +{"_id": "7814", "text": "A syndrome characterized by parkinsonism, hypoventilation, depression, and weight loss; caused by heterozygous mutation in the DCTN1 gene on chromosome 2p13.. The mean age at onset is 48 years; the mean disease duration is five years. Parkinsonism and psychiatric changes (depression, apathy, character changes, and withdrawal) tend to occur early; severe weight loss and hypoventilation manifest later."} +{"_id": "7817", "text": "A leukemia that develops slowly."} +{"_id": "7820", "text": "An autosomal recessive disease characterized by the accumulation of deposits of calcium and other minerals in elastic fibers, which are a component of connective tissue, this can result in changes in the skin, eyes, cardiovascular system and gastrointestinal system."} +{"_id": "7823", "text": "A thyroid carcinoma that has_material_basis_in compact bundles of long spindle epithelial cells that merge with tubulopapillary structures and/or mucinous glands."} +{"_id": "7826", "text": "A nephroblastoma that results_in either bilateral disease or a family history of Wilms' tumour."} +{"_id": "7829", "text": "A type of ALS caused_by mutation located_in ERBB4 gene located_in chromosome 2."} +{"_id": "7832", "text": "A syndrome that is characterized by four typical symptoms: polymorphous exanthemas, recurrent high fever, leucocytosis and arthralgia."} +{"_id": "7835", "text": "An endocrine gland cancer located_in the thryoid gland located in the neck below the thyroid cartilage."} +{"_id": "7838", "text": "A viral infectious disease that results_in infection in sheep and rarely humans, has_material_basis_in Louping ill virus, which is transmitted_by sheep tick, Ixodes ricinus. The infection has_symptom lethargy, has_symptom muscle pains, has_symptom fever, and has_symptom focal neurological signs."} +{"_id": "7841", "text": "An esophageal disease that is characterized by an inability of the esophagus to move food toward the stomach resulting from the lower esophogeal sphincter not fully relaxing during swallowing."} +{"_id": "7844", "text": "A syndrome that is characterized by intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, genital abnormalities and has_physical_basis_in heterozygous mutation in the CDKN1C gene."} +{"_id": "7847", "text": "A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis."} +{"_id": "7850", "text": "A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull."} +{"_id": "7853", "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine in goats, pigs and humans by the nematode Oesophagostomum bifurcum. The symptoms are a low-grade fever, tenderness in the lower-right quadrant and painless cutaneous masses in the lower abdominal region. Rarely, Oesophagostomum spp will perforate the bowel wall, causing purulent peritonitis or migrate to the skin, producing cutaneous nodules."} +{"_id": "7856", "text": "An anogenital venereal wart that results_in infection located_in skin of urethra, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct sexual contact with the skin of an infected partner. The infection has_symptom urethral warts."} +{"_id": "7859", "text": "A parasitic helminthiasis infectious disease that involves infection by parasitic worms known as flukes, which are carried to various organs through blood stream."} +{"_id": "7862", "text": "A myositis that results_in inflammation located_in muscle or located_in skin where a skin rash is often seen prior to the onset of muscle weakness. The disease may result from either a viral infection or an autoimmune reaction."} +{"_id": "7865", "text": "An atrial fibrillation that has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes."} +{"_id": "7868", "text": "A legionellosis that involves a milder respiratory illness without pneumonia. Symptoms include fever, headache and muscle aches which last for 2 to 5 days."} +{"_id": "7871", "text": "A focal dystonia that is characterized by a prolonged involuntary upward deviation of the eyes."} +{"_id": "7874", "text": "An eating disorder that is characterized by an appetite for non-nutritive substances or food ingredients."} +{"_id": "7877", "text": "A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp."} +{"_id": "7880", "text": "A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge."} +{"_id": "7883", "text": "A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred."} +{"_id": "7886", "text": "A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals."} +{"_id": "7889", "text": "A communication disorder that involves both the receptive and expressive areas of communication may be affected in any degree, from mild to severe."} +{"_id": "7892", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation."} +{"_id": "7895", "text": "A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. The legs cross at the knees, making it difficult to walk."} +{"_id": "7898", "text": "A synostosis that results_in craniosynostosis and syndactyly."} +{"_id": "7901", "text": "A Retroviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Lentivirus, which is transmitted_by sexual contact, transmitted_by breast feeding, and transmitted_by contact of infected blood with any open wound."} +{"_id": "7904", "text": "A gastrointestinal system cancer that is located_in the pharynx."} +{"_id": "7907", "text": "A mollusc allergy triggered by snails."} +{"_id": "7910", "text": "A rhabdomyosarcoma and sarcoma of the mediastinum that is located_in the mediastinum and affects children and adolescents."} +{"_id": "7913", "text": "A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head."} +{"_id": "7916", "text": "An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer."} +{"_id": "7919", "text": "A nipple carcinoma that is located_in the nipple duct."} +{"_id": "7922", "text": "A renal cell carcinoma that is characterized by the development of multiple, bilateral papillary renal tumors."} +{"_id": "7925", "text": "A hemangiopericytoma and sarcoma of the mediastinum that is located_in the mediastinum."} +{"_id": "7928", "text": "A leiomyosarcoma and sarcoma of lung that is located_in the lung."} +{"_id": "7931", "text": "A dermatophytosis that results_in fungal infection located_in skin, limited to the stratum corneum of the epidermis, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, and has_symptom red colored skin rash. The border of the rash lesions look scaly."} +{"_id": "7934", "text": "A Paramyxoviridae infectious disease that results_in infection in cattle and humans, has_material_basis_in Pneumovirus, which is transmitted_by contact with the respiratory secretions."} +{"_id": "7937", "text": "An aspergillosis that presents as a clump of tangled mass of Aspergillus fungus fibres, blood clots, and white blood cells, which exists in the cavities of the lungs that develop in an area of previous lung disease or lung scarring."} +{"_id": "7940", "text": "A penile cancer that is located_in the skin or tissues of the penis."} +{"_id": "7943", "text": "A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape."} +{"_id": "7946", "text": "A histiocytic and dendritic cell cancer that derives_from the lymph nodes, derives_from the skin, derives_from the liver, derives_from the spleen and derives_from bones."} +{"_id": "7949", "text": "A viral infectious disease that results_in infection in cats, located_in peritoneum, has_material_basis_in Feline infectious peritonitis virus, which is transmitted_by contact with the infected cat, and transmitted_by congenital method. The infection has_symptom sneezing, has_symptom watery eyes, has_symptom nasal discharge, and has_symptom accumulation of fluid in the abdomen."} +{"_id": "7952", "text": "A hereditary spastic paraplegia associated with dementia."} +{"_id": "7955", "text": "A specific phobia that involves an irrational fear of contracting a disease."} +{"_id": "7958", "text": "A substance abuse that involves the recurring use of barbiturate drugs despite negative consequences."} +{"_id": "7961", "text": "A maxillary sinusitis which lasts for less than 4 weeks."} +{"_id": "7964", "text": "A cryptococcosis that results_in inflammation located_in meninges, has_material_basis_in Cryptococcus neoformans and has_symptom headache, has_symptom nausea, has_symptom staggering gait, has_symptom dementia, has_symptom blurred vision and has_symptom confusion."} +{"_id": "7967", "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice."} +{"_id": "7970", "text": "A type of ALS with loci associated with the disease located_in chromosome 18."} +{"_id": "7973", "text": "A demyelinating disease characterized by the fact that the demyelinated tissues form concentric layers."} +{"_id": "7976", "text": "A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer."} +{"_id": "7979", "text": "An acrocephalosyndactylia that has_material_basis_in mutation in the GLI3 gene which results_in abnormal development located_in limb, located_in head, located_in face."} +{"_id": "7982", "text": "A male reproductive system cancer that is located_in the testicles."} +{"_id": "7985", "text": "A skin hemangioma characterized by the presence of small red dots that cluster together to form a linear or snake-like array or ring-shaped pattern located_in the blood vessels of the skin."} +{"_id": "7988", "text": "A cholesteatoma located_in paranasal sinus."} +{"_id": "7991", "text": "A pharynx cancer that is located_in the oropharynx."} +{"_id": "7994", "text": "A large intestine cancer that is located_in the anus."} +{"_id": "7997", "text": "An agnosia that is a loss of motion perception."} +{"_id": "8000", "text": "A neurodegenerative disease that is characterized by an abnormal accumulation of iron in the brain and progressive degeneration of the nervous system."} +{"_id": "8003", "text": "An immune system cancer located_in the thymus."} +{"_id": "8006", "text": "An autosomal recessive disease characterized_by is a rare autosomal recessive disease, characterized by microcephaly with brain anomalies including CA in some cases, intellectual disability, and early-infantile-onset nephrotic syndrome."} +{"_id": "8009", "text": "A congenital heart septal defect characterized by an abnormal or inadequate fusion of the superior and inferior endocardial cushions with the mid portion of the atrial septum and the muscular portion of the ventricular septum, thus allowing extra blood to circulate the lungs."} +{"_id": "8012", "text": "An extrapulmonary tuberculosis that results in formation of tiny lesions in all the organs."} +{"_id": "8015", "text": "A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Piedraia hortae, an ascomycetous fungus forming hard black nodules on the shafts of the scalp, beard, moustache and pubic hair."} +{"_id": "8018", "text": "A focal dystonia that involves the muscles that control the vocal cords, resulting in strained or breathy speech."} +{"_id": "8021", "text": "A rickets characterized by low levels of serum phosphate and elevated levels of ALP and phosphaturia and that has_material_basis_in autosomal dominant inheritance."} +{"_id": "8024", "text": "A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs."} +{"_id": "8027", "text": "A thymus cancer that derives_from epithelial cells. The tumor cells in a thymic carcinoma look very different from the normal cells of the thymus, grow more quickly, and have usually spread to other parts of the body when the cancer is found."} +{"_id": "8030", "text": "A (-)ssRNA virus infectious disease that results_in infection in rodents and humans, has_material_basis_in Bunyaviridae viruses, which are transmitted_by arthropod vectors."} +{"_id": "8033", "text": "A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus."} +{"_id": "8036", "text": "A syndrome that is characterized by developmental delay, intellectual disability, muscle weakness (hypotonia), epilepsy, distinctive facial features and congenital malformations of the heart, urogenital tract and the central nervous system, and has_physical_basis_in either a chromosome 17 (17q21.31) microdeletion or a mutation in the KANSL1-gene."} +{"_id": "8039", "text": "A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain."} +{"_id": "8042", "text": "A tick infestation that is characterized by an acute, ascending, flaccid motor paralysis, which is caused by the introduction of a neurotoxin into humans during attachment and feeding by the females of several tick species such as Dermacentor andersoni, Dermacentor variabilis, Amblyomma americanum, Amblyomma maculatum, Ixodes scapularis, Ixodes pacificus, Ixodes holocyclus, Rhipicephalus sanguineus and Otobius megnini. The symptoms include local inflammation, edema and hemorrhage."} +{"_id": "8045", "text": "A myiasis that involves parasitic infestation of warble flies of the genus Hypoderma, on cattle and deer and Dermatobia hominis on humans. The larvae of human botfly, Dermatobia hominis, feed in a subdermal cavity causing cutaneous swellings on the body or scalp that may produce discharges and be painful."} +{"_id": "8048", "text": "A intestinal cancer that is located_in the appendix."} +{"_id": "8051", "text": "A primary bacterial infectious disease that refers to a group of diseases, located_in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted_by lice, transmitted_by fleas, and transmitted_by mites."} +{"_id": "8054", "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Trivittatus virus, which is transmitted_by Ochlerotatus trivittatus mosquito. The infection has_symptom headache, has_symptom fever, has_symptom disorientation, has_symptom tremors, has_symptom convulsions, has_symptom paralysis, and has_symptom coma."} +{"_id": "8057", "text": "A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes."} +{"_id": "8060", "text": "A severe combined immunodeficiency that is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines. Lack of ADA causes accumulation of dATP."} +{"_id": "8063", "text": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis."} +{"_id": "8066", "text": "A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene."} +{"_id": "8069", "text": "A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts."} +{"_id": "8072", "text": "A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center."} +{"_id": "8075", "text": "An intestinal infectious disease and is_a Cytomegalovirus infectious disease that is complicated_by acquired immunodeficiency syndrome which results_in inflammation located_in colon and located_in small intestine, has_material_basis_in Cytomegalovirus in AIDS patients."} +{"_id": "8078", "text": "A syphilis that is characterized as having serologic proof of infection without signs or symptoms of disease."} +{"_id": "8081", "text": "A syndrome characterized by the combination of lower lip pits, cleft lip with or without cleft palate and cleft palate alone."} +{"_id": "8084", "text": "A nervous system disease that affects the peripheral nervous system."} +{"_id": "8087", "text": "A retinal disease that is characterized by nystagmus, sluggish or no pupillary responses, and severe vision loss or blindness."} +{"_id": "8090", "text": "A severe combined immunodeficiency that is caused when the DCLREI1, DNA cross-link repair 1C gene contains mutations resulting in the inability to repair DNA."} +{"_id": "8093", "text": "A spotted fever that has_material_basis_in Rickettsia conorii subsp israelensis, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities."} +{"_id": "8096", "text": "A Nematoda infectious disease that involves infection by parasitic worms of the class Chromadorea, characterized by body annules, elaborated and spiral amphids, and three esophageal glands."} +{"_id": "8099", "text": "An adrenal medulla cancer that is characterized by overproduction of adrenaline."} +{"_id": "8102", "text": "A syndrome that is characterized by hypotonia, congenital fiber type disproportion and dysharmonic skeletal maturation."} +{"_id": "8105", "text": "A keratosis of the hands and feet characterized by persistent, asymptomatic, yellowish to white papules and plaques associated with fine-textured scalp hair and an atopic diathesis."} +{"_id": "8108", "text": "An adenocarcinoma that derives_from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma."} +{"_id": "8111", "text": "A kidney cancer that affects the kidneys and typically located_in children."} +{"_id": "8114", "text": "A disease comprised of a group of signs and symptoms that occur together and characterize a particular abnormality."} +{"_id": "8117", "text": "A bone cancer that is located_in the femur."} +{"_id": "8120", "text": "A California virus encephalitis that results_in inflammation located_in brain, has_material_basis_in Jamestown Canyon virus, which is transmitted_by Culiseta, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom headache, has_symptom fever, has_symptom neck stiffness, has_symptom photophobia, has_symptom nausea, has_symptom vomiting, and has_symptom seizures."} +{"_id": "8123", "text": "An opportunistic mycosis that results_in fungal infection located_in nose, located_in sinuses, located_in eyes, and located_in brain of immunocompromised individuals and has_symptom orbital cellulitis, has_symptom proptosis, has_symptom pus discharge from the nose, and has_symptom seizures."} +{"_id": "8126", "text": "A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood."} +{"_id": "8129", "text": "A bone benign neoplasm that has_material_basis_in odontogenic epithelium and is located_in bone."} +{"_id": "8132", "text": "A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia."} +{"_id": "8135", "text": "A syndrome that is haracterized by the development of a one or more tumors (gastrinoma) in the pancreas, duodenum, or both that secrete excessive levels of gastrin, a hormone that stimulates production of acid by the stomach."} +{"_id": "8138", "text": "A severe combined immunodeficiency that is characterized by the absence of T cells but normal numbers of B cells. CD3D is essential for T cell development."} +{"_id": "8141", "text": "A male reproductive organ cancer that is located_in the prostate."} +{"_id": "8144", "text": "An 2-hydroxyglutaric aciduria that involves damage to cerebellum affecting movement coordination resulting in problems with balance and muscle coordination (ataxia)."} +{"_id": "8147", "text": "A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction."} +{"_id": "8150", "text": "A focal dystonia that is characterized by distortions of the mouth and tongue."} +{"_id": "8153", "text": "A fruit allergy triggered by Prunus domestica plant fruit food product."} +{"_id": "8156", "text": "An Enterovirus infectious disease that involves inflammation located_in brain, has_material_basis_in group A coxsackievirus or has_material_basis_in group B coxsackievirus, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom reduced level of consciousness, has_symptom confusion, has_symptom irritability, has_symptom seizures, and has_symptom coma."} +{"_id": "8159", "text": "A Mononegavirales infectious disease that results_in infection in animals and humans, has_material_basis_in Bornaviridae viruses."} +{"_id": "8162", "text": "An adult sarcoma of soft tissue and extraosseous osteosarcoma that is located in the soft tissues without direct attachment to the skeletal system and results in the production of osteoid, bone, or chondroid material."} +{"_id": "8165", "text": "An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall."} +{"_id": "8168", "text": "An achondrogenesis that results_in abnormal ossification of the located_in vertebral column or located_in spine."} +{"_id": "8171", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection by the nematode Dioctophyme renale in humans after eating undercooked food. The larvae are found in the subcutaneous nodules and kidneys."} +{"_id": "8174", "text": "A leiomyosarcoma and sarcoma of colon that is located_in the colon."} +{"_id": "8177", "text": "A hyperostosis of endosteal bone."} +{"_id": "8180", "text": "A commensal Helicobacter infectious disease that involves inflammation of the stomach lining caused by Helicobacter pylori, which contributes to ulcer formation by increasing acid production, interfering with the normal defenses against stomach acid, and producing toxins. The symptoms include indigestion and pain or discomfort in the upper abdomen."} +{"_id": "8183", "text": "A pneumoconiosis that results_in humans that also have rheumatoid arthritis."} +{"_id": "8186", "text": "A lymphocytic choriomeningitis that results_in inflammation located_in brain, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis."} +{"_id": "8189", "text": "An autosomal dominant disease that is characterized by fusion of the carpals, tarsals, and phalanges, short first metacarpals causing brachydactyly; and humeroradial fusion."} +{"_id": "8192", "text": "A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling."} +{"_id": "8195", "text": "A larynx cancer that has_material_basis_in epithelial cells."} +{"_id": "8198", "text": "A brain stem cancer that begins in the lower part of the brain on the floor of the skull."} +{"_id": "8201", "text": "A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies."} +{"_id": "8204", "text": "A vascular disease that is characterized by severe supine hypotension in late pregnancy, whose clinical presentation ranges from minimal cardiovascular alterations to severe shock, resulting from inferior vena cava compression by gravid uterus."} +{"_id": "8207", "text": "A primary bacterial infectious disease that results_in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash."} +{"_id": "8210", "text": "A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated."} +{"_id": "8213", "text": "A syndrome that occurs in human immunodeficiency virus (HIV) positive patients, which is accompanied by decreased kidney function. The spectrum of kidney involvement includes acute or chronic kidney disease, primarily tubular proteinuria and dense lymphocytic tubulointerstitial infiltrates predominantly composed of CD8 T cells."} +{"_id": "8216", "text": "An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues."} +{"_id": "8219", "text": "A tinea favosa that results_in anthropophilic fungal infection located_in scalp, has_material_basis_in Trichophyton schoenleinii. It is a chronic, scarring form of tinea capitis, which results_in_formation_of scutula and has_symptom permanent hair loss."} +{"_id": "8222", "text": "A disease of mental health in which the normally well-integrated functions of memory, identity, perception, or consciousness are separated (dissociated)."} +{"_id": "8225", "text": "A colitis caused_by introduction of various chemicals."} +{"_id": "8228", "text": "An achondrogenesis that has_material_basis_in mutation in the SLC26A2 gene which results_in umbilical or inguinal hernia and a prominent rounded abdomen."} +{"_id": "8231", "text": "An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands."} +{"_id": "8234", "text": "A bacterial pneumonia caused due to the infection by Gram-positive bacteria of genus Streptococcus which are the most common cause of community-acquired pneumonias."} +{"_id": "8237", "text": "An adrenal cortex disease characterized by small to normal sized adrenal glands containing multiple small cortical pigmented nodules."} +{"_id": "8240", "text": "An ethmoid sinus cancer that derives_from epithelial cells of glandular origin."} +{"_id": "8243", "text": "A lipid metabolism disorder characterized by an enzymatic defect that prevents long-chain fatty acids from being transported into the mitochondria."} +{"_id": "8246", "text": "A commensal bacterial infectious disease that involves infection of the intestine by the bacterium Clostridium difficile, which causes diarrhea, pseudomembranous colitis, toxic megacolon, intestinal perforation and sepsis. The symptoms include fever, loss of appetite, nausea and abdominal pain."} +{"_id": "8249", "text": "A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis."} +{"_id": "8252", "text": "An autosomal recessive disease that results from mutations in multiple BBS genes affecting cellular cilia structure or function (ciliopathy) resulting in variable presentation and characterized principally by obesity, retinitis pigmentosa,vision loss, polydactyly, mental retardation, hypogonadism, and renal failure in some cases."} +{"_id": "8255", "text": "An actinomycosis that involves invasion and infiltration located_in head and located_in neck, has_material_basis_in Actinomyces israelii. The infection results_in_formation_of abscesses following oral surgery or in patients with poor dental hygiene."} +{"_id": "8258", "text": "A syndrome characterized by a combination of hearing loss and visual impairment."} +{"_id": "8261", "text": "An astrocytoma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain."} +{"_id": "8264", "text": "A fallopian tube carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "8267", "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation."} +{"_id": "8270", "text": "An ovarian carcinoma that has_material_basis_in the lining of the ovary and produces a serum-like fluid."} +{"_id": "8273", "text": "A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance."} +{"_id": "8276", "text": "A middle ear disease characterized by an inflammation of the mucosal lining of the mastoid antrum and the mastoid air cell system inside the mastoid process."} +{"_id": "8279", "text": "A pulmonary tuberculosis involving inflammation of trachea and bronchi. The symptoms include dry cough followed by dyspnea, localized wheezing, hemoptysis, hoarseness, anorexia, weight loss, chest pain and fever."} +{"_id": "8282", "text": "A bile duct disease that is characterized by abnormal dilatation of the intrahepatic bile ducts."} +{"_id": "8285", "text": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain."} +{"_id": "8288", "text": "A gastrointestinal system cancer that is located_in the liver."} +{"_id": "8291", "text": "An inherited metabolic disorder characterized_by wide range of phenotypic variability; patients can have severe metabolic and CNS abnormalities, while others possess hyperglycerolemia and glyceroluria with no other apparent phenotype. It is caused by mutation in the GK gene on chromosome Xp21."} +{"_id": "8294", "text": "An electroclinical syndrome with onset in childhood between one and 12 years of age."} +{"_id": "8297", "text": "A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness."} +{"_id": "8300", "text": "An Epstein-Barr virus infectious disease and is_a lymphoma that derives_from lymphocytes, has_material_basis_in Human herpesvirus 4, which causes a growth activation of the lymphocytes that it infects."} +{"_id": "8303", "text": "A spinal muscular atrophy that is associated with the survival of motor neuron protein."} +{"_id": "8306", "text": "A synostosis characterized by coronal craniosynostosis, short stature, and aplasia or hypoplasia of the radial bone."} +{"_id": "8309", "text": "An urea cycle disorder that involves the accumulation of ammonia in the blood."} +{"_id": "8312", "text": "An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot."} +{"_id": "8315", "text": "A cholera that involves infection of the intestine caused by Vibrio cholerae O139 strain."} +{"_id": "8318", "text": "An eye and adnexa disease that is located_in the eye."} +{"_id": "8321", "text": "A tertiary neurosyphilis that is caused due to syphilis, which occurs suddenly and produces tinnitus and deafness when the cochlear branch is affected whereas vertigo, disturbances of equilibrium, spontaneous nystagmus and vomiting when the vestibular branch suffers. A combination of these symptoms are seen when both the branches are involved."} +{"_id": "8324", "text": "A type of ALS with juvenile onset caused_by mutation located_in SIGMAR1 gene (SETX) located_in chromosome 9."} +{"_id": "8327", "text": "A substance abuse that involves the recurring use of cocaine despite negative consequences."} +{"_id": "8330", "text": "A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding."} +{"_id": "8333", "text": "A phagocyte bactericidal dysfunction characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones may occur along with swollen areas of inflamed tissues known as granulomas that can be widely distributed."} +{"_id": "8336", "text": "An autosomal genetic disease that is characterized by microphthalmia or anophthalmia, pulmonary agenesis, and diaphragmatic defect."} +{"_id": "8339", "text": "An anxiety disorder that involves discress but neither delusions nor hallucinations."} +{"_id": "8342", "text": "A human papilloma virus related cervical squamous cell carcinoma that results_in infection located_in cervix, has_material_basis_in human papillomavirus (types 16 or 18), which cause papillary tumors with a transitional differentiation."} +{"_id": "8345", "text": "A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces."} +{"_id": "8348", "text": "A urinary system cancer that is located_in the kidney."} +{"_id": "8351", "text": "A lung disease that is a mycosis caused by fungal growth in the lungs."} +{"_id": "8354", "text": "A spotted fever that has_material_basis_in Rickettsia parkeri, which is transmitted_by Gulf Coast tick (Amblyomma maculatum). The infection has_symptom fever, has_symptom headache, has_symptom eschar, and has_symptom rash."} +{"_id": "8357", "text": "The most common type of familial ALS caused_by mutation located_in SOD1 gene located in chromosome 21."} +{"_id": "8360", "text": "A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty speaking, has_symptom difficulty swallowing, and has_symptom difficulty chewing."} +{"_id": "8363", "text": "A Mononegavirales infectious disease that results_in infection in animals and humans, has_material_basis_in Filoviridae viruses."} +{"_id": "8366", "text": "An oligohydramnios desribing the typical physical appearances of a fetus or neonate due to oligohydramnios experienced in the womb where there is a decrease in amniotic fluid volume sufficient to cause disruptions in morphogenesis of the fetus."} +{"_id": "8369", "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Togaviridae viruses."} +{"_id": "8372", "text": "A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine."} +{"_id": "8375", "text": "An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years."} +{"_id": "8378", "text": "A dysentery that involves protozoan infection."} +{"_id": "8381", "text": "A myocarditis characterized by dilated cardiomyopathy and a variety of types of dysrhythmia and conduction disturbances. It is caused by Corynebacterium diphtheriae."} +{"_id": "8384", "text": "A testis sarcoma that arises from mesenchymal cells and is located_in the testis."} +{"_id": "8387", "text": "A purulent acute otitis media with no perforation of the tympanic membrane."} +{"_id": "8390", "text": "A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness."} +{"_id": "8393", "text": "An osteoporosis caused by chronic glucocorticoid use. Glucocorticoids impair the replication, differentiation and function of osteoblasts and induce the apoptosis of mature osteoblasts and osteocytes; the also favor osteoclastogenesis leading to an increase in bone resorption."} +{"_id": "8396", "text": "A viral infectious disease that results_in infection located_in pharynx or located_in conjunctiva, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7, which are transmitted_by droplet spread of respiratory secretions or transmitted_by fomites. The infection has_symptom fever, has_symptom lymphadenopathy of the neck, and has_symptom headache."} +{"_id": "8399", "text": "A genetic disease that is characterized by slow growth before and after birth, intellectual disability that is usually severe to profound, skeletal abnormalities involving the arms and hands, and distinctive facial features."} +{"_id": "8402", "text": "An intestinal benign neoplasm that is located_in the colon."} +{"_id": "8405", "text": "An anthrax disease that results_in infection located_in mucosa of gastrointestinal tract, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite."} +{"_id": "8408", "text": "A syndrome that occurs in humans with psoriasis who also experience symptoms similar to arthritis."} +{"_id": "8411", "text": "A viral infectious disease that results_in inflammation located_in lung, has_material_basis_in Human parainfluenza virus 3, which is transmitted_by contact with the respiratory secretions of an infected person. The infection leads to the formation of multinucleated giant cells derived from the respiratory epithelium. The infection has_symptom shortness of breath, has_symptom cough, and has_symptom fever."} +{"_id": "8414", "text": "A notochordal cancer that derives_from cellular remnants of the notochord."} +{"_id": "8417", "text": "An epilepsy syndrome that is a group of clinical entities showing a cluster of electro-clinical characteristics, classified according to age at onset, cognitive and developmental antecedents and consequences, motor and sensory examinations, EEG features, provoking or triggering factors, and patterns of seizure occurrence with respect to sleep."} +{"_id": "8420", "text": "An arthritis that has_material_basis_in worn out cartilage located_in joint."} +{"_id": "8423", "text": "A carcinoma that derives_from myoepithelial cells."} +{"_id": "8426", "text": "A rickets that has_material_basis_in autosomal recessive inheritance mutation in the DMP1 gene and is haracterized by hypophosphatemia, rickets and/or osteomalacia and slow growth."} +{"_id": "8429", "text": "An adenoma that is composed_of adipose tissue."} +{"_id": "8432", "text": "A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium."} +{"_id": "8435", "text": "A breast carcinoma that derives_from the lining of milk ducts."} +{"_id": "8438", "text": "A carcinoma that derives_from squamous epithelial cells."} +{"_id": "8441", "text": "A cancer by anatomical entitiy that affects the organs in the abdominal cavity."} +{"_id": "8444", "text": "A multiple carboxylase deficiency that involves a deficiency in holocarboxylase synthetase."} +{"_id": "8447", "text": "A diverticulits characterized by the inflammation of a congenital diverticulum, which is a slight bulge of the small intestine present at birth."} +{"_id": "8450", "text": "A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain."} +{"_id": "8453", "text": "A myopathy is characterized by progressive skeletal muscle weakness degeneration."} +{"_id": "8456", "text": "A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve)."} +{"_id": "8459", "text": "A monogenic disease affects a person's height, muscles, skeleton, genitals, and appearance of the face."} +{"_id": "8462", "text": "A trypanosomiasis that involves infection of cattle caused by Trypanosoma vivax, which is transmitted by tsetse flies. The symptoms include fever, anemia, abortion, loss of appetite, lethargy, and progressive weight loss."} +{"_id": "8465", "text": "A type of ALS with juvenile onset caused_by mutation located_in alsin gene located_in chromosome 2."} +{"_id": "8468", "text": "An organ system cancer that located_in the heart and blood vessels."} +{"_id": "8471", "text": "A sinusitis which involves infection of ethmoid sinuses that causes pain or pressure behind and between the eyes, tearing, and headache over the forehead."} +{"_id": "8474", "text": "A dissociative disorder that involves the simultaneous display of multiple distinct identities or personalities."} +{"_id": "8477", "text": "A lymphatic system cancer that has_material_basis_in endothelial cells located_in lymphatic vessels."} +{"_id": "8480", "text": "A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition."} +{"_id": "8483", "text": "A nervous system cancer that is located_in the sensory system."} +{"_id": "8486", "text": "An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles)."} +{"_id": "8489", "text": "A sarcoma and malignant neoplasm of testis that is located_in the testis."} +{"_id": "8492", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Whitewater Arroyo virus, which is transmitted_by white-throated woodrats (Neotoma albigula). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, and has_symptom hemorrhagic manifestations."} +{"_id": "8495", "text": "A (+)ssRNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Astroviridae viruses."} +{"_id": "8498", "text": "An ovarian embryonal carcinoma that occurs in childhood."} +{"_id": "8501", "text": "An ovary adenocarcinoma that derives_from the lining of a cavity that produces a serum-like fluid (a serous cavity)."} +{"_id": "8504", "text": "An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss."} +{"_id": "8507", "text": "A lymphatic system disease characterized by he presence of intestinal lymphangiectasia, mental retardation, and characteristic facial anomalies. It in inherited in an autosomal recessive pattern. Most individuals with Hennekam syndrome have characteristic facial abnormalities, such as a flat face with accompanying puffy eyelids and hypertelorism; the nasal bridge is typically flat and the ears are typically small. Congenital extremity and genital lymphedema is present in most patients."} +{"_id": "8510", "text": "A chordoma that derives_from the spine."} +{"_id": "8513", "text": "A myiasis that involves parasitic infestation of Cochliomyia hominivorax or Chrysomya bezziana larvae, which feed on the living tissues of warm-blooded animals. In Cochliomyia infestation, larvae migrate from the subdermis to other tissues in the body, causing extreme damage in the process. Chrysomya bezziana larvae feed and can cause permanent tissue damage."} +{"_id": "8516", "text": "A food allergy triggered by fish."} +{"_id": "8519", "text": "An amebiasis that involves infection of the intestine with Entamoeba histolytica trophozoites, which adhere to and kill colonic epithelial cells causing diarrhea with blood and mucus. The symptoms inlcude abdominal pain and fever."} +{"_id": "8522", "text": "An adnexa disease that is located_in the eyelid."} +{"_id": "8525", "text": "A congenital structural myopathy characterized by generally non-progressive muscle weakness of varying severity; certain muscle fibers show the presence of rod-like structures called nemaline bodies."} +{"_id": "8528", "text": "An opportunistic mycosis that involves infection of the body by fungi belonging to the phylum Ascomycota."} +{"_id": "8531", "text": "A thyroid carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer."} +{"_id": "8534", "text": "A chromosomal disease that has_material_basis_in deletion polymorphisms at chromosome location 22q11 and is characterized by variable developmental problems and schizoid features."} +{"_id": "8537", "text": "An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss."} +{"_id": "8540", "text": "A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries."} +{"_id": "8543", "text": "A combined T cell and B cell immunodeficiency that is caused by a defect in several genes encoding for B and T lymphocytes resulting in individuals with non-functional immune systems."} +{"_id": "8546", "text": "A retroperitoneal cancer that has_material_basis_in immature nerve cells."} +{"_id": "8549", "text": "An agnosia that is a loss of the ability to distinguishing environmental and non-verbal auditory cues including difficulty distinguishing speech from non-speech sounds even though hearing is usually normal."} +{"_id": "8552", "text": "A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances."} +{"_id": "8555", "text": "A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs."} +{"_id": "8558", "text": "An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress."} +{"_id": "8561", "text": "A fish allergy triggered by Oncorhynchus mykiss."} +{"_id": "8564", "text": "A Parabasalia infectious disease that involves infection with anaerobic flagellate parasites belonging to the order Trichomonadida. They typically have four to six flagella at the cell's apical pole."} +{"_id": "8567", "text": "A female reproductive organ cancer that is located_in fallopian tube."} +{"_id": "8570", "text": "A sarcoma and malignant tumor of nasal sinuses that is located_in the paranasal sinus."} +{"_id": "8573", "text": "A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain."} +{"_id": "8576", "text": "A refractive error characterized by the inability to see farther objects clearly."} +{"_id": "8579", "text": "A onchocerciasis that involves parasitic infection of the eye by the larvae of Onchocerca volvulus. The microfilariae migrate to the surface of the cornea. Punctate keratitis occurs in the infected area. In severe infection, sclerosing keratitis occurs, making the affected area become opaque leading to blindness."} +{"_id": "8582", "text": "A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin."} +{"_id": "8585", "text": "A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas."} +{"_id": "8588", "text": "A heart disease that is caused by high blood pressure."} +{"_id": "8591", "text": "A vulva carcinoma and has_material_basis_in squamous cells and is located_in the epidermis of the vulvar tissue."} +{"_id": "8594", "text": "A skin cancer that is located_in tissues of the skin and develops from epithelial cells."} +{"_id": "8597", "text": "An autosomal recessive disesase that is characterized by sensorineural hearing loss and ovarian failure."} +{"_id": "8600", "text": "A thoracic disease that is located_in the breast."} +{"_id": "8603", "text": "A congenital hypoplastic anemia that is characterized by anemia (low red blood cell counts) with decreased erythroid progenitors in the bone marrow and has_material_basis insufficient levels of red blood cells due to bone marrow dysfunction."} +{"_id": "8606", "text": "An interstitial lung disease that is caused by the inhalation of dust."} +{"_id": "8609", "text": "A pericarditis characterized by inflammation, occurring after injury, located_in pericardium."} +{"_id": "8612", "text": "A hematoloic cancer that is located_in the blood or bone marrow that has come back in a patient."} +{"_id": "8615", "text": "An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain."} +{"_id": "8618", "text": "A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis."} +{"_id": "8621", "text": "An autosomal recessive disease that is characterized by mental retardation, cataracts, coloboma, kyphosis, and coarse facial features and has_material_basis_in mutation in the SRD5A3 gene."} +{"_id": "8624", "text": "An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods."} +{"_id": "8627", "text": "An agnosia that is a loss of the ability to recognize a color, while being able to perceive or distinguish it."} +{"_id": "8630", "text": "A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue."} +{"_id": "8633", "text": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice."} +{"_id": "8636", "text": "An autosomal recessive disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1)."} +{"_id": "8639", "text": "A mixed neoplasm that is seen mostly in early infancy and that consists of classic and cellular (atypical) variants."} +{"_id": "8642", "text": "A secretory diarrhea caused_by mutation in the SLC26A3 gene."} +{"_id": "8645", "text": "A type of ALS caused_by mutation located_in ANG gene located_in chromosome 14."} +{"_id": "8648", "text": "A Cytomegalovirus infectious disease that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 5, has_symptom nausea, has_symptom vomiting, has_symptom headache, has_symptom abdominal pain, has_symptom dark urine, and has_symptom jaundice. Clinical feature includes atypical lymphocytes in the blood."} +{"_id": "8651", "text": "A hypolipoproteinemia that is characterized by an inablility to fully absorb dietary fats, cholesterol and fat-soluble vitamins, has_physical_basis_in an autosomal recessive disorder of lipid metabolism caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL)."} +{"_id": "8654", "text": "A Rubella virus infectious disease that results_in inflammation located_in brain, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom confusion, has_symptom drowsiness, has_symptom delirium, has_symptom convulsions, has_symptom cranial nerve palsies, and has_symptom coma."} +{"_id": "8657", "text": "A bone inflammation disease that involves rupture of the growth plate in children located_in tibia."} +{"_id": "8660", "text": "An alveolar soft part sarcoma that has not spread to other parts of the body."} +{"_id": "8663", "text": "A glycogen storage disease that has_material_basis_in deficiency of the lysosomal acid alpha-glucosidase enzyme resulting in damage to muscle and nerve cells due to an accumulation of glycogen in the lysosome."} +{"_id": "8666", "text": "A thymus cancer that derives_from epithelial cells located_in the thymus. The tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus."} +{"_id": "8669", "text": "A viral infectious disease that results_in infection causing reproductive failure of sows and respiratory problems of piglets and growing pigs, has_material_basis_in Porcine reproductive and respiratory syndrome virus, which is transmitted_by contact with feces, urine and semen of infected pigs, and transmitted_by fomites. The infection has_symptom stillborn piglets, has_symptom mummified fetuses, has_symptom premature farrowings, has_symptom weak-born pigs, and has_symptom pneumonia."} +{"_id": "8672", "text": "A thyroid gland disease which involves an underproduction of thyroid hormone."} +{"_id": "8675", "text": "A kidney cancer which is manifested in the kidney."} +{"_id": "8678", "text": "A sarcoma and malignant mediastinal mesenchymnal tumor that is located_in the mediastinum."} +{"_id": "8681", "text": "A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances."} +{"_id": "8684", "text": "A carcinoma that is located_in the inside of the abdomen."} +{"_id": "8687", "text": "A squamous cell carcinoma that contains squamous cells and gland-like cells."} +{"_id": "8690", "text": "A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons."} +{"_id": "8693", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems."} +{"_id": "8696", "text": "Ulcer of lower limbs is a chronic ulcer of skin where the ulcer is not a decubitus ulcer."} +{"_id": "8699", "text": "An epilepsy characterized by seizures triggered by visual stimuli that form patterns in space or time, such as flashing lights."} +{"_id": "8702", "text": "A personality disorder that is characterized by a pervasive psychological dependence on other people."} +{"_id": "8705", "text": "A human papillomavirus related squamous cell carcinoma that results_in infection located_in penis, has_material_basis_in human papillomavirus (types 16 and 18), which cause malignant tumors in squamous epithelium of the penis."} +{"_id": "8708", "text": "An endocrine gland cancer that has_material_basis_in neuroendocrine cells."} +{"_id": "8711", "text": "A male reproductive organ cancer that derives_from epithelial cells of glandular origin."} +{"_id": "8714", "text": "An autosomal recessive disease characterized by oculocutaneous albinism, bleeding problems due to platelet storage pool defect, visual impairment and lysosomal accumulation of ceroid lipofuscin."} +{"_id": "8717", "text": "A parasitic protozoa infectious disease that involves infection of the large intestine by a protozoan parasite Dientamoeba fragilis. The symptoms include diarrhea, stomach pain and cramping, loss of appetite and weight, nausea, and fatigue."} +{"_id": "8720", "text": "A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues."} +{"_id": "8723", "text": "A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins."} +{"_id": "8726", "text": "A sarcoma and malignant neoplasm of urinary bladder that is located_in the bladder."} +{"_id": "8729", "text": "An ampulla of Vater cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "8732", "text": "An urethra cancer that derives_from epithelial cells of glandular origin."} +{"_id": "8735", "text": "An X-linked disease characterized by retardation, hyperactivity, hypotonia, broad thumbs, big first toes and a characteristic facial appearance including macrocephaly and has an X-linked recessive inheritance pattern."} +{"_id": "8738", "text": "A bartonellosis that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain."} +{"_id": "8741", "text": "A hypersensitivity reaction type II disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis."} +{"_id": "8744", "text": "An adenovirus infectious disease that results_in inflammation located_in meninges, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7 and has_symptom fever, has_symptom headache, has_symptom stiff neck, and has_symptom confusion."} +{"_id": "8747", "text": "A viral infectious disease results_in infection located_in skin, or located_in mucous membranes of the mouth, oesophagus, larynx or trachea of birds, has_material_basis_in Fowlpox virus, has_symptom lesions on the skin, has_symptom diphtheritic lesions in the upper parts of the digestive and respiratory tracts."} +{"_id": "8750", "text": "A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance."} +{"_id": "8753", "text": "An anus carcinoma that derives_from epithelial cells of glandular origin located_in the anal colloid."} +{"_id": "8756", "text": "A Herpesviridae infectious disease that results_in infection in children, has_material_basis_in Human herpesvirus 6 and has_material_basis_in Human herpesvirus 7."} +{"_id": "8759", "text": "A Kaposi's sarcoma that located_in older men of Italian or Eastern European Jewish origin. Kaposi's sarcoma results_in slow-growing lesions on the legs and feet."} +{"_id": "8762", "text": "An autosomal dominant disease that is characterized by \\nand has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers."} +{"_id": "8765", "text": "An upper respiratory tract disease involving inflammation of the nasal cavities and trachea caused by feline herpesvirus 1, of the family Herpesviridae in cats and especially young kittens that is characterized by sneezing, conjunctivitis with discharge, and nasal discharges."} +{"_id": "8768", "text": "A Flavivirus infectious disease that results_in infection in animals and humans, has_material_basis_in West Nile virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom nausea, has_symptom vomiting, has_symptom swollen lymph glands, or has_symptom skin rash on the chest, stomach and back."} +{"_id": "8771", "text": "A middle ear cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "8774", "text": "A lung disease characterized by inadequate gas exchange by the respiratory system."} +{"_id": "8777", "text": "An amino acid metabolic disorder that has_material_basis_in a mutation in the GATM gene resulting in deficiency of arginine:glycine amidinotransferase which then limits creatine synthesis."} +{"_id": "8780", "text": "A DNA virus infectious disease that results_in infection, has_material_basis_in ssDNA viruses, which possess single-stranded DNA."} +{"_id": "8783", "text": "A pancreatic ductal carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "8786", "text": "An autosomal recessive disease that is characterised by severe reduction or absence of the fibula and complex brachydactyly."} +{"_id": "8789", "text": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring."} +{"_id": "8792", "text": "A toxoplasmosis that involves infection of the heart with Toxoplasma gondii resulting in shortness of breath and constricting chest pain."} +{"_id": "8795", "text": "A corneal disease in which the cornea blends with sclera, resulting in clouding of the cornea."} +{"_id": "8798", "text": "A tyrosinemia that has_material_basis_in deficiency of 4-hydroxyphenylpyruvate dioxygenase disrupting the break down of tyrosine."} +{"_id": "8801", "text": "A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract."} +{"_id": "8804", "text": "A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails."} +{"_id": "8807", "text": "A musculoskeletal system cancer that is located_in connective tissue."} +{"_id": "8810", "text": "Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus."} +{"_id": "8813", "text": "An endodermal sinus tumor that occurs in adults."} +{"_id": "8816", "text": "A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability."} +{"_id": "8819", "text": "A DNA virus infectious disease that results_in infection, has_material_basis_in dsDNA retro-transcribing viruses, which possess double-stranded DNA genomes and replicate using reverse transcriptase."} +{"_id": "8822", "text": "An ancylostomiasis that is characterized by skin manifestations (cutaneous larva migrans) occuring due to migrating larvae of Ancylostoma braziliense in the upper epidermis. It is marked by the presence of erythematous, serpiginous and pruritic cutaneous eruptions."} +{"_id": "8825", "text": "A pericardial effusion that results from blood in the pericardial sac."} +{"_id": "8828", "text": "A leukemia that occurs in children."} +{"_id": "8831", "text": "A cervical adenosquamous carcinoma that is a rare form and is composed of cells with a glass-like cytoplasm."} +{"_id": "8834", "text": "A rickettsiosis that is caused by the genus Rickettsia. This infection results in pleural effusions and pulmonary edema."} +{"_id": "8837", "text": "A fruit allergy triggered by Ziziphus mauritiana plant fruit food product."} +{"_id": "8840", "text": "An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs."} +{"_id": "8843", "text": "A Charcot-Marie-Tooth disease characterized by demyelinating or axonal abnormalities that has_material_basis_in autosomal recessive inheritance."} +{"_id": "8846", "text": "A syndrome characterized by calcinosis, Raynaud's phenomeno, esophageal dysmotility, sclerodactyly and telangiectasia."} +{"_id": "8849", "text": "A B cell deficiency that is caused by mutations in the IGLL1 gene. Lambda 5 mutations an cause a block in B cell development at the transition between the pro-B cell and the pre-B cell stage."} +{"_id": "8852", "text": "An endocrine system disease that is located_in the parathyroid gland."} +{"_id": "8855", "text": "An adenofibroma that is composed_of epithelial ovarian tissue."} +{"_id": "8858", "text": "A mood disorder that involves the presence of a low mood almost daily over a span of at least two years."} +{"_id": "8861", "text": "A nervous system benign neoplasm that is located_in a sensory organ."} +{"_id": "8864", "text": "A respiratory system cancer that is located_in the bronchus."} +{"_id": "8867", "text": "A viral infectious disease that results_in infection in cattle, has_material_basis_in Bovine ephemeral fever virus, which is transmitted_by Culex, transmitted_by Anopheles, and transmitted_by Culicoides arthropods. The infection has_symptom fever, has_symptom stiffness, has_symptom lameness, has_symptom nasal discharge, has_symptom ocular discharge, has_symptom depression, has_symptom cessation of rumination, and has_symptom constipation."} +{"_id": "8870", "text": "A coccidioidomycosis that results_in pneumonia located_in lungs, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom pleuritic chest pain, has_symptom respiratory failure, has_symptom pleural effusion, and results_in_formation_of pulmonary nodules."} +{"_id": "8873", "text": "A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney."} +{"_id": "8876", "text": "A type of ALS with loci associated with the disease located_in chromosome 20."} +{"_id": "8879", "text": "A parasitic helminthiasis infectious disease that involves infection by metacestode larval stage (coenurus) of Taenia multiceps or Taenia serialis. Coenuri in the skin or subcutaneous tissue present as painless nodules, which manifest on the trunk, sclera, subconjuctiva, neck, shoulders, head and limbs. Coenuri in the central nervous system may cause headache, fever, vomiting, nerve palsies, jacksonian epilepsy, pachymeningitis, obstructive or communicating hydrocephalus, and intracranial arteritis with transient hemiparesis. Coenuri in the eye cause both intraocular and orbital infections."} +{"_id": "8882", "text": "A Human immunodeficiency virus infectious disease that results_in infection characterized by chronic diarrhea lasting longer than 1 month, without an identified infectious cause after thorough evaluation, in an HIV-positive individual, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. It is observed that HIV-infected individuals have histologic abnormalities of the gastrointestinal mucosa, malabsorption, and lymphocyte depletion causing diarrhea, increased gastrointestinal inflammation, increased intestinal permeability, and malabsorption of bile acid and vitamin B12."} +{"_id": "8885", "text": "A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss."} +{"_id": "8888", "text": "An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which affects bone growth and results_in a small body, hydrops fetalis, and abnormal ossification located_in vertebral column or located_in pelvis. The disease has_symptom enlarged abdomen."} +{"_id": "8891", "text": "An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system."} +{"_id": "8894", "text": "A thyroid medullary carcinoma that has_material_basis_in autosomal dominant inheritance."} +{"_id": "8897", "text": "An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland."} +{"_id": "8900", "text": "A sex differentiation disease that is characterized by the partial or complete inability of the cell to respond to androgens in individuals with a karyotype of 46,XY resulting in female physical traits but male genetic makeup."} +{"_id": "8903", "text": "A hematologic cancer that has_material_basis_in mast cells."} +{"_id": "8906", "text": "A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses)."} +{"_id": "8909", "text": "A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions."} +{"_id": "8912", "text": "An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease."} +{"_id": "8915", "text": "A spotted fever that has_material_basis_in Rickettsia heilongjiangensis, which is transmitted_by ticks (Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom maculopapular rash, and has_symptom regional adenopathy."} +{"_id": "8918", "text": "A Simplexvirus infectious disease that results_in inflammation located_in meninges, has_material_basis_in Human herpesvirus 2 and has_symptom headache, has_symptom fever, and has_symptom meningism."} +{"_id": "8921", "text": "A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health."} +{"_id": "8924", "text": "A viral infectious disease that results_in infection located_in eyes or located_in upper respiratory tract of domestic rabbits, has_material_basis_in Myxoma virus, which is transmitted_by mosquitos, transmitted_by biting flies or transmitted_by direct contact. The infection has_symptom conjunctivitis with a milky discharge from the inflamed eye and has_symptom breathing difficulties."} +{"_id": "8927", "text": "A dendritic cell sarcoma cancer that effects the follicular dendritic cells."} +{"_id": "8930", "text": "A type of ALS caused_by mutation located_in CHCHD10 gene located_in chromosome 22. It is characterized by adult onset of either frontotemporal dementia and/or amyotrophic lateral sclerosis."} +{"_id": "8933", "text": "A cancer that is classified by the type of cell from which it is derived."} +{"_id": "8936", "text": "A cell type benign neoplam that is composed_of epithelial tissue on papillae of vascularized connective tissue."} +{"_id": "8939", "text": "A carcinoma that derives_from transitional epithelial cells."} +{"_id": "8942", "text": "A eustachian tube disorder which involves inflammation of the mucous membrane of the cartilagenous portion of the eustachian tube caused by acute nasopharyngitis, infection from some pathogenic microbes or trauma of the tube."} +{"_id": "8945", "text": "A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis."} +{"_id": "8948", "text": "A spotted fever that has_material_basis_in Rickettsia conorii subsp indica, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities."} +{"_id": "8951", "text": "A dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking."} +{"_id": "8954", "text": "A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset."} +{"_id": "8957", "text": "An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions)."} +{"_id": "8960", "text": "A hypogonadism that is characterized by a progressive loss of germ cells on the developing gonads of an embryo."} +{"_id": "8963", "text": "A parasitic helminthiasis infectious diseasea that involves infection of the eyes in humans by nematode Thelazia callipaeda causing varying degrees of inflammation and lacrimation. In heavier infections, photophobia, edema, conjunctivitis, and blindness occurs."} +{"_id": "8966", "text": "A syndrome that involves pre-excitation of the ventricles due to an accessory pathway providing an abnormal electrical communication from the atria to the ventricles."} +{"_id": "8969", "text": "A cell type cancer that has_material_basis_in mesothelial tissue."} +{"_id": "8972", "text": "An upper respiratory tract disease characterized by the unusual growth of the adenoid tonsil; has_symptom snoring, has_symptom hyponasality, has_symptom otitis media with effusion, has symptom mouth breathing."} +{"_id": "8975", "text": "A primary systemic mycosis that results_in fungal infection located_in skin and located_in subcutaneous tissue through direct inoculation from wood splinters or hay, has_material_basis_in Sporothrix schenckii, a dimorphic fungus, which results_in_formation_of erythematous papulonodular lesions evolving into either smooth or verrucose painless nodules that may ulcerate and drain."} +{"_id": "8978", "text": "An aspergillosis that involves infection of the lung with Aspergillus, which causes pneumonia in people with an impaired immune system. The symptoms include wheezing, coughing and fever."} +{"_id": "8981", "text": "A pneumonia involving inflammation of the lungs caused by bacteria."} +{"_id": "8984", "text": "An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain."} +{"_id": "8987", "text": "An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response."} +{"_id": "8990", "text": "An autosomal disease characterized by varying degrees of deafness, minor defects in structures arising from the neural crest and pigmentation anomalies of the hair, the skin and/or the iris of both eyes."} +{"_id": "8993", "text": "An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism."} +{"_id": "8996", "text": "A connective tissue disease that is characterized by elongation and generalized tortuosity of the major arteries including the aorta."} +{"_id": "8999", "text": "A viral infectious disease that results_in inflammation located_in stomach and located_in intestine, has_material_basis_in Rotavirus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by fomites. The infection has_symptom fever, has_symptom vomiting, has_symptom diarrhea, and has_symptom abdominal pain."} +{"_id": "9002", "text": "A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal."} +{"_id": "9005", "text": "An opiate dependence that involves the continued use of heroin despite problems related to use of the substance."} +{"_id": "9008", "text": "A Retroviridae infectious disease that results_in infection in animals and humans, has_material_basis_in Deltaretrovirus, which is transmitted_by congenital method, and transmitted_by sexual contact."} +{"_id": "9011", "text": "A Mumps virus infectious disease that results_in inflammation located_in brain, has_material_basis_in Mumps virus, which is transmitted_by contact with the oronasal secretions of an infected person. The infection has_symptom convulsions, has_symptom drowsiness, has_symptom rigidity of limbs, and has_symptom slurred speech."} +{"_id": "9014", "text": "An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle."} +{"_id": "9017", "text": "A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood."} +{"_id": "9020", "text": "A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment."} +{"_id": "9023", "text": "A Mumps virus infectious disease that results_in inflammation located_in meninges, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom severe headache, and has_symptom neck stiffness."} +{"_id": "9026", "text": "A viral infectious disease that results_in infection, has_material_basis_in DNA viruses, which have DNA as their genetic material and replicate using a DNA-dependent DNA polymerase."} +{"_id": "9029", "text": "A cervix disease characterized by a benign polyp on the surface of the cervical canal."} +{"_id": "9032", "text": "A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has_symptom blurred vision."} +{"_id": "9035", "text": "A colitis characterized by an overgrowth of Clostridium difficile bacteria."} +{"_id": "9038", "text": "A type of ALS caused_by mutation located_in VAPB gene located_in chromosome 20."} +{"_id": "9041", "text": "A nonsyndromic deafness characterized by an autosomal recessive inheritance mode."} +{"_id": "9044", "text": "An Epstein-Barr virus related lymphoma and is_a posttransplantation lymphoproliferative disorder that derives_from lymphocytes after organ transplant, has_material_basis_in Human herpesvirus 4."} +{"_id": "9047", "text": "An ectothrix infectious disease that results_in anthropophilic fungal infection located_in skin and located_in hair, has_material_basis_in Microsporum ferrugineum."} +{"_id": "9050", "text": "A cheilitis characterized by inflammation of one or both of the corners of the mouth."} +{"_id": "9053", "text": "A gastrointestinal system benign neoplasm that is located_in the intestine."} +{"_id": "9056", "text": "A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells."} +{"_id": "9059", "text": "A cecum cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "9062", "text": "An endocrine system disease that is located_in the thyroid."} +{"_id": "9065", "text": "A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions."} +{"_id": "9068", "text": "A testicular cancer that has_material_basis_in germ cells."} +{"_id": "9071", "text": "A commensal streptococcal infectious disease that involves infection of the pharynx and sometimes the larynx and tonsils. It is caused by Group A Streptococcus bacteria. The common symptoms include fever, sore throat, headache, stomach ache, nausea, or chills."} +{"_id": "9074", "text": "A parasitic protozoa infectious disease that involves infection caused by euglenozoans, which are single-celled flagellates."} +{"_id": "9077", "text": "A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes."} +{"_id": "9080", "text": "A lice infestation that is a cutaneous condition caused by parasitic infestation of body lice Pediculus humanus corporis, which feed on the human blood. Body lice can spread epidemic typhus, trench fever, and louse-borne relapsing fever."} +{"_id": "9083", "text": "A chronic purulent otitis media which involves perforation in the attic region (pars flaccida of the tympanic membrane) or at the posterosuperior margin, with in-growth of squamous epithelium into the middle ear. This is caused as a result of poor ventilation of the middle ear and episodes of infection."} +{"_id": "9086", "text": "An esophageal cancer that arises from transformed cells of mesenchymal origin sarcoma and located_in the esophagus."} +{"_id": "9089", "text": "A disease of mental health where symptoms are deliberately produced, feigned or exaggerated in order to falsely demonstrate the presence of an illness."} +{"_id": "9092", "text": "A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum."} +{"_id": "9095", "text": "A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year."} +{"_id": "9098", "text": "A brain glioma that has_material_basis_in oligodendrocytes."} +{"_id": "9101", "text": "A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite."} +{"_id": "9104", "text": "An intestinal disease characterized by inflammation located_in all parts of digestive tract."} +{"_id": "9107", "text": "A sarcoma that is located_in the gallbladder."} +{"_id": "9110", "text": "An Enterovirus infectious disease that results_in inflammation located_in heart, has_material_basis_in Human enterovirus B, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions."} +{"_id": "9113", "text": "A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from two germinal layers of tissue."} +{"_id": "9116", "text": "A bone carcinoma that derives_from squamous epithelial cells."} +{"_id": "9119", "text": "An African histoplasmosis that results_in inflammation located_in endocardium, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom murmurs, has_symptom peripheral edema, has_symptom pulmonary rales, has_symptom petechia and has_symptom skin lesions."} +{"_id": "9122", "text": "A retinoblastoma that refers to bilateral retinoblastoma associated with an intracranial primitive neuroectodermal tumor located_in the pineal or suprasellar region."} +{"_id": "9125", "text": "A tic disorder that consists of multiple motor and/or phonic tics with duration of at least 4 weeks, but less than 12 months."} +{"_id": "9128", "text": "A hemangiopericytoma which is manifested in the central nervous system."} +{"_id": "9131", "text": "A pigmentation disease characterized by reticulate hyper- and hypo-pigmentated macules in a generalized distribution."} +{"_id": "9134", "text": "A thymic carcinoma that derives_from squamous cells and gland-like cells."} +{"_id": "9137", "text": "A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain."} +{"_id": "9140", "text": "An osteochondrodysplasia that has_material_basis_in a mutation in chromosome 17 which results_in bowing in the located_in tibia or located_in femur."} +{"_id": "9143", "text": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "9146", "text": "A pulmonary tuberculosis characterized by bronchial compression and obstruction as a result of enlarged lymph nodes of the primary complex or by infiltration of the wall of the bronchi by caseous lymph nodes."} +{"_id": "9149", "text": "An endocrine gland cancer located_in the pancreas."} +{"_id": "9152", "text": "A tularemia that results_in painful regional lymphadenopathy and an ulcerated skin lesion."} +{"_id": "9155", "text": "A small intestine sarcoma that affects the involuntary smooth muscles of the small intestines."} +{"_id": "9158", "text": "An exostosis that has_material_basis_in a mutation on the genes EXT1, EXT2 and EXT3 which results_in multiple bony spurs throughout a child's growth."} +{"_id": "9161", "text": "An urticaria induced by stroking of the skin."} +{"_id": "9164", "text": "A urinary system disease that is located_in the kidney."} +{"_id": "9167", "text": "A strongyloidiasis that involves infection of intestine with Strongyloides stercoralis, which results in abdominal pain, diarrhea, ileus, massive gastrointestinal bleeding, severe malabsorption, and peritonitis."} +{"_id": "9170", "text": "A synostosis that results_in the fusion of two or more digits."} +{"_id": "9173", "text": "A lymphoblastic leukemia that is characterized by over production of lymphoblasts."} +{"_id": "9176", "text": "An extracranial neuroblastoma that has_material_basis_in immature nerve cells."} +{"_id": "9179", "text": "A syndrome characterized by defects of the scalp (aplasia cutis congenita), abnormalities of the fingers, toes, arms and legs."} +{"_id": "9182", "text": "An actinomycosis that involves invasion and infiltration located_in brain, has_material_basis_in Actinomyces israelii. The infection results_in_formation_of brain abscess."} +{"_id": "9185", "text": "A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning."} +{"_id": "9188", "text": "A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia."} +{"_id": "9191", "text": "An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum."} +{"_id": "9194", "text": "A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis."} +{"_id": "9197", "text": "A gamma-amino butyric acid metabolism disorder that is characterized by a defect in the gene coding for gamma-aminobutyrate transaminase, which is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde."} +{"_id": "9200", "text": "An autosomal recessive disease that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB)."} +{"_id": "9203", "text": "A filarial elephantiasis that involves parasitic infection by the nematode Brugia timori, which inhabits the lymphatics. The symptoms include fever and chronic lymphedema."} +{"_id": "9206", "text": "A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp."} +{"_id": "9209", "text": "An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood."} +{"_id": "9212", "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine, liver and lungs caused by Capillaria species."} +{"_id": "9215", "text": "A thyroid gland disease that involves an abnormal enlargement of the thyroid gland."} +{"_id": "9218", "text": "A parasitic protozoa infectious disease that involves infection caused by amoeboid protozoa."} +{"_id": "9221", "text": "A neurodegenerative disease that is characterized by intraneuronal inclusions of mutant neuroserpin resulting in progressive encephalopathy, dementia and seizures and has_material_basis_in a mutation in the SERPINI1 gene inherited in an in autosomal dominant pattern."} +{"_id": "9224", "text": "A leiomyosarcoma and sarcoma of the anus that is located_in the anus."} +{"_id": "9227", "text": "A Pseudomonas infectious disease that is caused by a Gram-negative bacterium Pseudomonas aeruginosa resulting in pulmonary edema. This bacterium releases immunogenic bacterial components that can gain access to airway epithelium and immune cells in the lung thus causing airway inflammation. P. aeruginosa is the common cause of hospital acquired and ventilator-associated pneumonias."} +{"_id": "9230", "text": "A lipodystrophy and is_a Human immunodeficiency virus infectious disease that is characterized by loss of subcutaneous fat, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. Anti-retroviral medications are also associated with the disease. The infection has_symptom fat loss in face, buttocks, arms, legs."} +{"_id": "9233", "text": "A skin disease characterized_by growth of keratin on the skin or mucous membranes."} +{"_id": "9236", "text": "A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles."} +{"_id": "9239", "text": "An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other."} +{"_id": "9242", "text": "A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells."} +{"_id": "9245", "text": "A viral infectious disease that results_in inflammation located_in brain and located_in spinal cord of pigs, has_material_basis_in Porcine teschovirus, which is transmitted_by ingestion of contaminated food, and transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom anorexia, has_symptom depression, has_symptom incoordination, has_symptom paralysis, has_symptom muscle tremors, has_symptom stiffness, has_symptom nystagmus, has_symptom seizures, and has_symptom loss of the voice."} +{"_id": "9248", "text": "A carcinoma that derives_from the cells that line an organ."} +{"_id": "9251", "text": "A parasitic helminthiasis infectious disease that involves parasitic infection of the liver of a variety of wild and domestic ruminants by Fascioloides magna."} +{"_id": "9254", "text": "A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles."} +{"_id": "9257", "text": "A carcinoma in situ that is characterized by the spread of cancer in skin and the lack of invasion of surrounding tissues."} +{"_id": "9260", "text": "A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. The rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous."} +{"_id": "9263", "text": "An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in undeveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull."} +{"_id": "9266", "text": "A viral infectious disease that results_in infection in cattle, has_material_basis_in Rinderpest virus, which is transmitted_by direct contact with an infected animal, or transmitted_by ingestion of contaminated water. The infection has_symptom fever, has_symptom nasal and eye discharge, and results_in_formation_of erosions in the mouth, the lining of the nose and the genital tract."} +{"_id": "9269", "text": "A sleep disorder that involves involuntary limb movement during sleep."} +{"_id": "9272", "text": "An inflammatory bowel disease that is characterized by patchy areas of inflammation located_in jejunum, has_symptom abdominal pain, has_symptom diarrhea, has_symptom cramps and has_symptom formation of fistulas."} +{"_id": "9275", "text": "A myeloid leukemia that is characterized by over production of white blood cells."} +{"_id": "9278", "text": "A dsDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Poxviridae viruses."} +{"_id": "9281", "text": "A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face."} +{"_id": "9284", "text": "An angiosarcoma and hemangioma of skin and malignant skin vascular tumor and sarcoma of skin that is located_in the skin and results_in an enlarged bruise (a blue-black nodule) and an unhealed ulceration."} +{"_id": "9287", "text": "A carcinosarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium."} +{"_id": "9290", "text": "A Parkinson's disease caused by mutation in the alpha-synuclein gene, SNCA, on chromosome 4q22.1."} +{"_id": "9293", "text": "A pulmonary valve disease that occurs when the pulmonary valve is not strong enough to prevent backflow into the right ventricle. If it is secondary to pulmonary hypertension it is referred to as a Graham Steell murmur."} +{"_id": "9296", "text": "A cell type benign neoplasm that is composed of lipocytes."} +{"_id": "9299", "text": "A myopathy characterized by abnormally located nuclei in skeletal muscle cells. The nuclei are located in the center of the cell, instead of their normal location at the periphery."} +{"_id": "9302", "text": "A Varicellovirus infectious disease that results_in inflammation located_in external ear canal, has_material_basis_in Human herpesvirus 3, has_symptom pain in the outer ear, and has_symptom ear discharge."} +{"_id": "9305", "text": "A parasitic ectoparasitic infectious disease that involves infestation of lice, which are blood-feeding ectoparasitic insects of the order Phthiraptera."} +{"_id": "9308", "text": "A histoplasmosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains."} +{"_id": "9311", "text": "A DNA virus infectious disease that results_in infection, has_material_basis_in dsDNA viruses, which possess double-stranded DNA."} +{"_id": "9314", "text": "An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates."} +{"_id": "9317", "text": "A mixed neoplasm that consist of epithelial tissue, and stromal or mesenchymal tissue."} +{"_id": "9320", "text": "A lung small cell carcinoma that is characterized as a multiphasic lung cancer comprised of a mixture of small cell and non-small cell lung carcinoma cells."} +{"_id": "9323", "text": "A mucopolysaccharidosis characterized by a deficiency in hyaluronidase."} +{"_id": "9326", "text": "A primary bacterial infectious disease that is a sexually transmitted infection located_in skin of the genitals, has_material_basis_in Haemophilus ducreyi, which is transmitted_by sexual contact. The infection has_symptom painful and soft ulcers."} +{"_id": "9329", "text": "An amino acid metabolic disorder that iis caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum."} +{"_id": "9332", "text": "A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures."} +{"_id": "9335", "text": "An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland."} +{"_id": "9338", "text": "A spondyloepimetaphyseal dysplasia that is characterized by short stature, short and bowed lower limbs, mild brachydactyly, kyphoscoliosis, abnormal gait, enlarged knee joints, precocious osteoarthropathy, and normal intelligence."} +{"_id": "9341", "text": "A primary Campylobacter infectious disease that involves inflammation of the stomach and intestines caused by Campylobacter jejuni infection, which is characterized by diarrhea (may be bloody), abdominal pain, fever and vomiting."} +{"_id": "9344", "text": "A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever."} +{"_id": "9347", "text": "A muscular disease that is located_in the diaphragm."} +{"_id": "9350", "text": "A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues."} +{"_id": "9353", "text": "A cardiovascular cancer that is located_in blood vessels."} +{"_id": "9356", "text": "A disease that involves any biological process (GO:0008150) specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms."} +{"_id": "9359", "text": "A Paramyxoviridae infectious disease that results_in infection in birds and rarely humans, has_material_basis_in Avulavirus, which is transmitted_by direct contact with droppings and secretions from the nose, mouth, and eyes."} +{"_id": "9362", "text": "An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus."} +{"_id": "9365", "text": "A nasopharyngeal disease which involves inflammation of the nasal passages and upper part of the pharynx."} +{"_id": "9368", "text": "A sublingual gland cancer that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ."} +{"_id": "9371", "text": "A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly."} +{"_id": "9374", "text": "A disease by infectious agent that results_in infection, has_material_basis_in Viruses."} +{"_id": "9377", "text": "A HIV encephalopathy that results_in inflammation located_in white matter of neuraxis, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom weakness, has_symptom paralysis, has_symptom vision loss, has_symptom impaired speech, and has_symptom cognitive deterioration."} +{"_id": "9380", "text": "A central nervous system disease that involves encephalitis which occurs along with meningitis."} +{"_id": "9383", "text": "An autosomal dominant disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins."} +{"_id": "9386", "text": "A selective immunoglobulin deficiency disease that is the result of a deficiency of immunoglobulin A (IgA), an antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract."} +{"_id": "9389", "text": "An ectothrix infectious disease that results_in zoophilic fungal infection located_in scalp and located_in hair, has_material_basis_in Trichophyton equinum."} +{"_id": "9392", "text": "A candidiasis that involves inflammation of the gastric mucosa caused by Candida albicans infection. The symptoms include dyspepsia, gastric ulcers, gastric perforations, nausea and vomiting."} +{"_id": "9395", "text": "An impulse control disorder that involves abnormalities in memory, social and sexual functioning and idiosyncratic behaviors resulting from damage from trauma or infection to both temporal lobes causing individuals to put objects in their mouths and engage in inappropriate sexual behavior."} +{"_id": "9398", "text": "A bile duct cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "9401", "text": "A Nidovirales infectious disease that results_in infection in animals, has_material_basis_in Arteriviridae viruses."} +{"_id": "9404", "text": "A keratosis characterized by abnormal thickening of the palms and the soles."} +{"_id": "9407", "text": "A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body."} +{"_id": "9410", "text": "A disease by infectious agent that results_in infection, has_material_basis_in Bacteria."} +{"_id": "9413", "text": "A mansonelliasis that involves parasitic infection by the nematode Mansonella streptocerca, which resides in the dermis and subcutaneous tissue causing pruritus, papular eruptions and pigmentation changes. Midges transmit the disease."} +{"_id": "9416", "text": "A non-Hodgkin lymphoma that has_material_basis_in mucosal tissue involved in antibody production."} +{"_id": "9419", "text": "An urea cycle disorder that involves arginase deficiency resulting in elevated levels of plasma arginine."} +{"_id": "9422", "text": "A T-cell leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions."} +{"_id": "9425", "text": "A parasitic helminthiasis infectious disease that involves infection of the intestine in horses by the nematode Strongylus equinus."} +{"_id": "9428", "text": "A Cytomegalovirus infectious disease that results_in inflammation, located_in lung, has_material_basis_in Human herpesvirus 5, a member of a group of herpes-type viruses especially in people who have a suppressed immune system and has_symptom cough, has_symptom fatigue, has_symptom shortness of breath, and has_symptom hypoxemia. Cytomegalovirus infection can be demonstrated microscopically by the detection of intranuclear inclusion bodies."} +{"_id": "9431", "text": "An intestinal infectious disease that involves inflammation of the intestines, especially colon, due to chemical irritants, bacteria, protozoa, or parasitic worms, which results in severe diarrhea with passage of mucus and blood."} +{"_id": "9434", "text": "A mitochondrial metabolism disease that has material basis in mutation in the ATPAF2 gene on chromosome 17p11."} +{"_id": "9437", "text": "A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzymes galactose 6-sulfate sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain."} +{"_id": "9440", "text": "A Chagas disease that involves deterioration of the function of the myocardium caused due to Trypanosoma cruzi infection, which leads to heart rhythm abnormalities and may result in sudden death."} +{"_id": "9443", "text": "An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation."} +{"_id": "9446", "text": "A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly."} +{"_id": "9449", "text": "A chronic myeloproliferative and megakaryocytic tumor and thrombocytosis that is a rare chronic disorder that results_in the overproduction of platelets."} +{"_id": "9452", "text": "An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "9455", "text": "A severe combined immunodeficiency that is the result of a mutation on Chromosome 6 RAG2 gene involving genetic rearrangement of both the T- and B-lymphocyte receptor genes."} +{"_id": "9458", "text": "A tuberculosis that occurs at body sites other than the lung."} +{"_id": "9461", "text": "A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia."} +{"_id": "9464", "text": "A neonatal diabetes mellitus characterized by hyperglycemia during the neonatal period that remits during infancy but recurs in later life in most patients."} +{"_id": "9467", "text": "An ischemic bone disease the has_material_basis_in nitrogen embolization located_in bone."} +{"_id": "9470", "text": "An idiopathic generalized epilepsy characterized by onset of multiple seizure types in the first few years of life and associated with poor prognosis. Affected individuals have cognitive regression and intellectual disability."} +{"_id": "9473", "text": "A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning."} +{"_id": "9476", "text": "A dementia and a synucleinopathy that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities."} +{"_id": "9479", "text": "An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac."} +{"_id": "9482", "text": "An autosomal recessive genetic disease characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease."} +{"_id": "9485", "text": "An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected."} +{"_id": "9488", "text": "An autosomal recessive disease characterized by permanent parathyroid hormone (PTH) deficiency, hypocalcemia, hyperphosphatemia, facial anomalies, and psychomotor retardation; it is seen among children born to consanguineous couple of Arab ethnicity."} +{"_id": "9491", "text": "A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them."} +{"_id": "9494", "text": "A lung disease with an unknown etiology affecting the lungs which results in bleeding from tiny alveolar capillaries. Examination of sputum and bronchoalveolar lavage fluid can disclose hemosiderin-laden alveolar macrophages (siderophages), and the lung biopsy shows numerous siderophages in the alveoli. Alveolar hemorrhage is characterized by hemoptysis, dyspnea, alveolar infiltrates on chest radiograph, and various degrees of anaemia. Following a bleeding episode, the alveolar macrophages convert the hemoglobin's iron into hemosiderin within 36-72h."} +{"_id": "9497", "text": "An anogenital venereal wart that results_in infection located_in cervix, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct sexual contact with the skin of an infected partner. The infection has_symptom cervical warts."} +{"_id": "9500", "text": "A methylmalonic acidemia that is characterized by the accumulation of cobalamin in lysosomes which is then unable to synthesize the cofactors adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl)."} +{"_id": "9503", "text": "A melanoma that has_material_basis_in melanocytes located_in mucosal membranes lining the respiratory, gastrointestinal and urogenital tract."} +{"_id": "9506", "text": "A viral infectious disease that results in increased proliferation of affected CD4 lymphocytes, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The person infected with HTLV-1 eventually develop an often rapidly fatal leukemia, while others will develop a debilitative myelopathy, uveitis, infectious dermatitis, or another inflammatory disorder."} +{"_id": "9509", "text": "A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings."} +{"_id": "9512", "text": "A hypersensitivity reaction type II disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes."} +{"_id": "9515", "text": "A non-suppurative otitis media and eustachian tube disorder in which the tube is either too narrow or too wide. It can also be cuased by nasal inflammation which leads to inflammatory swelling and obstruction of the eustachian tube, which, in turn, leads to increased negative pressure in the middle ear and improper ventilation."} +{"_id": "9518", "text": "An articulation disorder characterized by involuntary sound repetition and disruption or blocking of speech."} +{"_id": "9521", "text": "A Mononegavirales infectious disease that results_in infection in animals and humans, has_material_basis_in Paramyxoviridae viruses."} +{"_id": "9524", "text": "An amino acid metabolic disorder that involves the formation of cystine stones in the kidneys, ureter, and bladder."} +{"_id": "9527", "text": "An agnosia that is a loss of the ability to distinguish the fingers on the hand."} +{"_id": "9530", "text": "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle."} +{"_id": "9533", "text": "A bone cancer that is manifested in the long bones of the lower limb."} +{"_id": "9536", "text": "A hemangiopericytoma that is manifested in the breast."} +{"_id": "9539", "text": "A carcinoma that results from uncontrolled proliferation of transformed cells of epithelial origin, which has no epithelial structural differentiation."} +{"_id": "9542", "text": "A rectum sarcoma that is located_in the rectum in which the cancer cells are thought to arise from skeletal muscle progenitors."} +{"_id": "9545", "text": "A parietal lobe neoplasm that has_material_basis_in cells lining the ventricles of the brain."} +{"_id": "9548", "text": "An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms."} +{"_id": "9551", "text": "A mitochondrial metabolism disease that has_material_basis_in a mutation in the SCO2 gene which encodes a COX assembly factor and results in deficiency of cytochrome c oxidase."} +{"_id": "9554", "text": "An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism."} +{"_id": "9557", "text": "A chronic conjunctivitis that is an inflammation of the conjunctiva involing red, itchy, and watery eyes a resulting from an exposure to an allergen or an irritant."} +{"_id": "9560", "text": "A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum."} +{"_id": "9563", "text": "An autoimmune disease that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels."} +{"_id": "9566", "text": "A hypersensitivity reaction type I disease located in the gastrointestinal tract."} +{"_id": "9569", "text": "A gastrointestinal system cancer that is located_in the esophagus."} +{"_id": "9572", "text": "A jaw cancer and mandibular disease that affects your lower jawbone."} +{"_id": "9575", "text": "A snail allergy triggered by Turbo cornutus."} +{"_id": "9578", "text": "A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively."} +{"_id": "9581", "text": "An appendix cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "9584", "text": "A disease of anatomical entity that is located_in reproductive system organs."} +{"_id": "9587", "text": "A uveal cancer that has_material_basis_in uvea pigment cells."} +{"_id": "9590", "text": "A skin disease that is located_in the sebaceous gland."} +{"_id": "9593", "text": "A sarcoma that is located_in the skin or located_in tissues that line or cover internal organs and that contains long spindle-shaped cells."} +{"_id": "9596", "text": "A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy."} +{"_id": "9599", "text": "A non-suppurative otitis media and eustachian tube disorder which is persistent and long-lasting."} +{"_id": "9602", "text": "A peripheral nervous system neoplasm that is located_in the connective tissue surrounding nerves."} +{"_id": "9605", "text": "A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes."} +{"_id": "9608", "text": "Collecting duct carcinoma is a renal cell carcinoma described as a rare and aggressive type of renal cell carcinoma. The cancerous cells form irregular tubes inside the tumor. Collecting duct carcinoma is more common among young people and unfortunately is diagnosed in most cases when the cancer has metastasized (spread inside the body)."} +{"_id": "9611", "text": "An X-linked disease resulting from a deficiency in N-terminal acetyltransferase, characterized by postnatal growth failure with severe delays and dysmorphic features in boys."} +{"_id": "9614", "text": "An Escherichia coli intestinal infectious disease that involves infection of the intestine caused by a serological subgroup of Escherichia coli called enteropathogenic Escherichia coli (EPEC), which has a plasmid-encoded protein referred to as EPEC adherence factor that enables localized adherence of bacteria to intestinal cells and a non fimbrial adhesin designated intimin, which is an outer membrane protein that mediates the final stages of adherence. EPEC induce a profuse watery (sometimes bloody) diarrhea."} +{"_id": "9617", "text": "A colorectal cancer that is located_in the rectum."} +{"_id": "9620", "text": "An autosomal dominant disease characterized by familial granulomatous arthritis, uveitis and skin granulomas caused_by NOD2/CARD15 mutations."} +{"_id": "9623", "text": "A B-cell lymphocytic neoplasm characterized by an uncontrolled increase of B-cells."} +{"_id": "9626", "text": "An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles."} +{"_id": "9629", "text": "A labyrinthine disease characterized by an abnormal bone growth in the middle ear."} +{"_id": "9632", "text": "A Human immunodeficiency virus infectious disease that results_in infection with mild symptoms, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2. The infection has_symptom swollen lymph glands, has_symptom fever, has_symptom diarrhea, and has_symptom weight loss."} +{"_id": "9635", "text": "A cognitive disorder that involves an excessive, irrational dread of everyday situations."} +{"_id": "9638", "text": "A rickets that results has_material_basis in X-linked mutations in the PHEX gene that lead to increased circulating levels of FGF-23, a phosphate-regulating hormone (phosphatonin), that leads to reduced renal phosphate reabsorption and consequently abnormal bone mineralization."} +{"_id": "9641", "text": "A cervical carcinosarcoma that is located_in the cervix."} +{"_id": "9644", "text": "A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."} +{"_id": "9647", "text": "A cecum carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "9650", "text": "An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation."} +{"_id": "9653", "text": "A rhabdomyosarcoma and sarcoma of bile duct that is located_in the bile duct."} +{"_id": "9656", "text": "An interstitial nephritis endemic to the regions along the Danube river, in the modern countries of Croatia, Bosnia and Herzegovina, Serbia, Romania and Bulgaria."} +{"_id": "9659", "text": "A factitious disorder that involves a care giver's deliberate exaggeration, fabrication, and/or induce physical, psychological, behavioral, and/or mental health problems in others."} +{"_id": "9662", "text": "A myiasis that involves parasitic infestation of Oestrus ovis larvae in the eye causing severe irritation, edema, and pain."} +{"_id": "9665", "text": "A renal pelvis carcinoma that derives_from epithelial cells of glandular origin."} +{"_id": "9668", "text": "An apocrine sweat gland cancer that derives_from epithelial cells of glandular origin."} +{"_id": "9671", "text": "A Charcot-Marie-Tooth disease that is characterized by pyramidal features including extensor plantar responses, mild increase in tone, and preserved or increased reflexes but no spastic gait."} +{"_id": "9674", "text": "An adrenal gland cancer that is located_in the adrenal medulla."} +{"_id": "9677", "text": "A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting."} +{"_id": "9680", "text": "An electroclinical syndrome with onset in adolescence and adulthood."} +{"_id": "9683", "text": "A bone inflammation disease that is located_in joint."} +{"_id": "9686", "text": "An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face."}