{ "form": [ { "box": [ 115, 207, 127, 215 ], "text": "pH", "label": "question", "words": [ { "box": [ 115, 207, 127, 215 ], "text": "pH" } ], "linking": [ [ 0, 16 ] ], "id": 0 }, { "box": [ 112, 349, 155, 358 ], "text": "SOLUBILITY", "label": "question", "words": [ { "box": [ 112, 349, 155, 358 ], "text": "SOLUBILITY" } ], "linking": [ [ 1, 19 ] ], "id": 1 }, { "box": [ 124, 434, 132, 443 ], "text": "", "label": "question", "words": [ { "box": [ 124, 434, 132, 443 ], "text": "" } ], "linking": [ [ 2, 20 ] ], "id": 2 }, { "box": [ 123, 485, 144, 494 ], "text": "ORAL", "label": "question", "words": [ { "box": [ 123, 485, 144, 494 ], "text": "ORAL" } ], "linking": [ [ 3, 21 ] ], "id": 3 }, { "box": [ 127, 162, 158, 173 ], "text": "A221", "label": "answer", "words": [ { "box": [ 127, 162, 158, 173 ], "text": "A221" } ], "linking": [ [ 12, 4 ] ], "id": 4 }, { "box": [ 119, 885, 156, 893 ], "text": "SIGNATURE", "label": "question", "words": [ { "box": [ 119, 885, 156, 893 ], "text": "SIGNATURE" } ], "linking": [ [ 5, 32 ] ], "id": 5 }, { "box": [ 190, 909, 221, 918 ], "text": "CENTER", "label": "other", "words": [ { "box": [ 190, 909, 221, 918 ], "text": "CENTER" } ], "linking": [], "id": 6 }, { "box": [ 154, 909, 186, 918 ], "text": "RESEARCH", "label": "other", "words": [ { "box": [ 154, 909, 186, 918 ], "text": "RESEARCH" } ], "linking": [], "id": 7 }, { "box": [ 115, 912, 152, 921 ], "text": "LORILLARD", "label": "other", "words": [ { "box": [ 115, 912, 152, 921 ], "text": "LORILLARD" } ], "linking": [], "id": 8 }, { "box": [ 646, 643, 667, 731 ], "text": "87428306", "label": "other", "words": [ { "box": [ 646, 643, 667, 731 ], "text": "87428306" } ], "linking": [], "id": 9 }, { "box": [ 511, 880, 530, 891 ], "text": "DATE", "label": "question", "words": [ { "box": [ 511, 880, 530, 891 ], "text": "DATE" } ], "linking": [ [ 10, 34 ] ], "id": 10 }, { "text": "COMPOUND PHYSICAL PARAMETERS", "box": [ 258, 119, 545, 136 ], "linking": [], "label": "header", "words": [ { "text": "COMPOUND", "box": [ 258, 120, 357, 136 ] }, { "text": "PHYSICAL", "box": [ 361, 122, 439, 135 ] }, { "text": "PARAMETERS", "box": [ 443, 119, 545, 136 ] } ], "id": 11 }, { "text": "LRC FILE NUMBER", "box": [ 114, 152, 175, 162 ], "linking": [ [ 12, 4 ] ], "label": "question", "words": [ { "text": "LRC", "box": [ 114, 154, 129, 162 ] }, { "text": "FILE", "box": [ 130, 154, 145, 162 ] }, { "text": "NUMBER", "box": [ 144, 152, 175, 160 ] } ], "id": 12 }, { "text": "LOT NUMBER", "box": [ 508, 147, 556, 158 ], "linking": [], "label": "question", "words": [ { "text": "LOT", "box": [ 508, 147, 523, 158 ] }, { "text": "NUMBER", "box": [ 521, 148, 556, 156 ] } ], "id": 13 }, { "text": "PHYSICAL STATE", "box": [ 115, 179, 171, 188 ], "linking": [ [ 14, 15 ] ], "label": "question", "words": [ { "text": "PHYSICAL", "box": [ 115, 180, 147, 188 ] }, { "text": "STATE", "box": [ 148, 179, 171, 188 ] } ], "id": 14 }, { "text": "A crystalline solid at room temperature which melts at > 56 C.", "box": [ 128, 184, 547, 202 ], "linking": [ [ 14, 15 ] ], "label": "answer", "words": [ { "text": "A", "box": [ 128, 190, 140, 202 ] }, { "text": "crystalline", "box": [ 143, 189, 222, 202 ] }, { "text": "solid", "box": [ 225, 189, 261, 201 ] }, { "text": "at", "box": [ 266, 189, 281, 201 ] }, { "text": "room", "box": [ 286, 190, 319, 201 ] }, { "text": "temperature", "box": [ 322, 189, 398, 201 ] }, { "text": "which", "box": [ 402, 187, 439, 200 ] }, { "text": "melts", "box": [ 443, 186, 482, 201 ] }, { "text": "at", "box": [ 483, 186, 500, 201 ] }, { "text": ">", "box": [ 505, 184, 514, 200 ] }, { "text": "56", "box": [ 513, 184, 528, 199 ] }, { "text": "C.", "box": [ 527, 184, 547, 201 ] } ], "id": 15 }, { "text": "The pH of a 50 % concentration of A221 in water was theoretically calculated to be 7.26 at 22 C from a 0.5 % solution in 79.5 % aqueous dioxane according to the extrapolation procedures of Dr. P. D. Schickedantz, Lozillard Accession Number 1662. Referenced 45- 10- 1.", "box": [ 128, 219, 588, 277 ], "linking": [ [ 0, 16 ] ], "label": "answer", "words": [ { "text": "The", "box": [ 128, 222, 149, 233 ] }, { "text": "pH", "box": [ 155, 222, 171, 237 ] }, { "text": "of", "box": [ 176, 222, 192, 235 ] }, { "text": "a", "box": [ 197, 226, 206, 237 ] }, { "text": "50", "box": [ 211, 222, 223, 237 ] }, { "text": "%", "box": [ 225, 221, 233, 236 ] }, { "text": "concentration", "box": [ 239, 222, 329, 235 ] }, { "text": "of", "box": [ 334, 221, 350, 236 ] }, { "text": "A221", "box": [ 356, 221, 385, 236 ] }, { "text": "in", "box": [ 389, 222, 405, 234 ] }, { "text": "water", "box": [ 409, 222, 446, 233 ] }, { "text": "was", "box": [ 449, 223, 472, 232 ] }, { "text": "theoretically", "box": [ 477, 219, 569, 235 ] }, { "text": "calculated", "box": [ 130, 237, 200, 249 ] }, { "text": "to", "box": [ 203, 238, 219, 249 ] }, { "text": "be", "box": [ 222, 237, 242, 248 ] }, { "text": "7.26", "box": [ 246, 234, 274, 250 ] }, { "text": "at", "box": [ 281, 237, 296, 249 ] }, { "text": "22", "box": [ 301, 235, 316, 248 ] }, { "text": "C", "box": [ 316, 237, 332, 248 ] }, { "text": "from", "box": [ 334, 235, 366, 247 ] }, { "text": "a", "box": [ 369, 238, 377, 247 ] }, { "text": "0.5", "box": [ 382, 235, 403, 246 ] }, { "text": "%", "box": [ 404, 235, 412, 247 ] }, { "text": "solution", "box": [ 417, 234, 473, 249 ] }, { "text": "in", "box": [ 477, 235, 494, 247 ] }, { "text": "79.5", "box": [ 499, 235, 527, 248 ] }, { "text": "%", "box": [ 527, 235, 535, 246 ] }, { "text": "aqueous", "box": [ 539, 237, 588, 250 ] }, { "text": "dioxane", "box": [ 128, 250, 179, 262 ] }, { "text": "according", "box": [ 182, 250, 248, 265 ] }, { "text": "to", "box": [ 251, 251, 267, 260 ] }, { "text": "the", "box": [ 271, 251, 294, 262 ] }, { "text": "extrapolation", "box": [ 301, 249, 391, 262 ] }, { "text": "procedures", "box": [ 393, 250, 467, 263 ] }, { "text": "of", "box": [ 471, 249, 486, 261 ] }, { "text": "Dr.", "box": [ 489, 250, 513, 259 ] }, { "text": "P.", "box": [ 517, 250, 533, 261 ] }, { "text": "D.", "box": [ 539, 250, 554, 261 ] }, { "text": "Schickedantz,", "box": [ 128, 262, 216, 277 ] }, { "text": "Lozillard", "box": [ 222, 263, 289, 275 ] }, { "text": "Accession", "box": [ 291, 263, 355, 275 ] }, { "text": "Number", "box": [ 361, 263, 404, 274 ] }, { "text": "1662.", "box": [ 409, 262, 442, 275 ] }, { "text": "Referenced", "box": [ 457, 262, 525, 275 ] }, { "text": "45-", "box": [ 527, 262, 548, 273 ] }, { "text": "10-", "box": [ 548, 262, 568, 273 ] }, { "text": "1.", "box": [ 567, 263, 580, 274 ] } ], "id": 16 }, { "text": "SPECIFIC GRAVITY", "box": [ 115, 287, 178, 298 ], "linking": [ [ 17, 18 ] ], "label": "question", "words": [ { "text": "SPECIFIC", "box": [ 115, 289, 147, 298 ] }, { "text": "GRAVITY", "box": [ 147, 287, 178, 296 ] } ], "id": 17 }, { "text": "Not Determined.", "box": [ 128, 305, 234, 317 ], "linking": [ [ 17, 18 ] ], "label": "answer", "words": [ { "text": "Not", "box": [ 128, 305, 149, 317 ] }, { "text": "Determined.", "box": [ 155, 305, 234, 317 ] } ], "id": 18 }, { "text": "MUTAGENICITY SOLVENTS A221 is soluble EtOH at 0.2 g/ ml, with stirring, at room temperature. Reference BC30- 88.", "box": [ 126, 361, 536, 399 ], "linking": [ [ 1, 19 ] ], "label": "answer", "words": [ { "text": "MUTAGENICITY", "box": [ 126, 361, 177, 370 ] }, { "text": "SOLVENTS", "box": [ 176, 361, 215, 370 ] }, { "text": "A221", "box": [ 127, 372, 156, 385 ] }, { "text": "is", "box": [ 160, 373, 179, 384 ] }, { "text": "soluble", "box": [ 182, 372, 233, 383 ] }, { "text": "", "box": [ 238, 372, 254, 384 ] }, { "text": "EtOH", "box": [ 258, 370, 289, 383 ] }, { "text": "at", "box": [ 293, 372, 310, 384 ] }, { "text": "0.2", "box": [ 313, 369, 336, 385 ] }, { "text": "g/", "box": [ 341, 369, 354, 386 ] }, { "text": "ml,", "box": [ 354, 369, 373, 385 ] }, { "text": "with", "box": [ 381, 370, 412, 383 ] }, { "text": "stirring,", "box": [ 416, 369, 475, 385 ] }, { "text": "at", "box": [ 483, 372, 499, 384 ] }, { "text": "room", "box": [ 505, 372, 536, 383 ] }, { "text": "temperature.", "box": [ 126, 386, 212, 399 ] }, { "text": "Reference", "box": [ 225, 385, 288, 398 ] }, { "text": "BC30-", "box": [ 293, 386, 326, 397 ] }, { "text": "88.", "box": [ 326, 385, 349, 397 ] } ], "id": 19 }, { "text": "A221 forms a solution in corn oil at 0.5 g/ 0.5 mL, with stirring at room temperature. Reference BC30- 8888.", "box": [ 127, 436, 567, 466 ], "linking": [ [ 2, 20 ] ], "label": "answer", "words": [ { "text": "A221", "box": [ 127, 440, 154, 451 ] }, { "text": "forms", "box": [ 160, 439, 196, 451 ] }, { "text": "a", "box": [ 202, 441, 211, 450 ] }, { "text": "solution", "box": [ 214, 439, 274, 452 ] }, { "text": "in", "box": [ 278, 440, 294, 451 ] }, { "text": "corn", "box": [ 298, 440, 329, 449 ] }, { "text": "oil", "box": [ 334, 439, 355, 450 ] }, { "text": "at", "box": [ 358, 439, 374, 450 ] }, { "text": "0.5", "box": [ 380, 436, 403, 451 ] }, { "text": "g/", "box": [ 408, 437, 423, 450 ] }, { "text": "0.5", "box": [ 422, 437, 445, 450 ] }, { "text": "mL,", "box": [ 447, 439, 471, 451 ] }, { "text": "with", "box": [ 476, 437, 507, 449 ] }, { "text": "stirring", "box": [ 511, 437, 567, 454 ] }, { "text": "at", "box": [ 127, 455, 142, 466 ] }, { "text": "room", "box": [ 147, 455, 176, 466 ] }, { "text": "temperature.", "box": [ 182, 453, 265, 466 ] }, { "text": "Reference", "box": [ 278, 452, 344, 465 ] }, { "text": "BC30-", "box": [ 348, 452, 381, 464 ] }, { "text": "8888.", "box": [ 381, 452, 400, 464 ] } ], "id": 20 }, { "text": "A221 forms a solution in corn oil at 0.5 g/ 0.5 mL, with stirring at room temperature. Reference BC30- 88.", "box": [ 127, 504, 568, 535 ], "linking": [ [ 3, 21 ] ], "label": "answer", "words": [ { "text": "A221", "box": [ 128, 507, 156, 519 ] }, { "text": "forms", "box": [ 160, 507, 197, 519 ] }, { "text": "a", "box": [ 202, 508, 213, 520 ] }, { "text": "solution", "box": [ 214, 505, 274, 518 ] }, { "text": "in", "box": [ 278, 505, 293, 520 ] }, { "text": "corn", "box": [ 298, 508, 327, 519 ] }, { "text": "oil", "box": [ 332, 505, 356, 518 ] }, { "text": "at", "box": [ 361, 505, 374, 518 ] }, { "text": "0.5", "box": [ 380, 505, 401, 518 ] }, { "text": "g/", "box": [ 408, 504, 424, 520 ] }, { "text": "0.5", "box": [ 424, 504, 444, 519 ] }, { "text": "mL,", "box": [ 447, 505, 470, 518 ] }, { "text": "with", "box": [ 475, 507, 506, 519 ] }, { "text": "stirring", "box": [ 509, 505, 568, 518 ] }, { "text": "at", "box": [ 127, 520, 143, 535 ] }, { "text": "room", "box": [ 147, 521, 178, 532 ] }, { "text": "temperature.", "box": [ 179, 521, 263, 533 ] }, { "text": "Reference", "box": [ 275, 519, 343, 532 ] }, { "text": "BC30-", "box": [ 348, 519, 381, 531 ] }, { "text": "88.", "box": [ 381, 519, 401, 531 ] } ], "id": 21 }, { "text": "ACUTE CARDIOVASCULAR", "box": [ 116, 574, 205, 584 ], "linking": [ [ 22, 23 ] ], "label": "question", "words": [ { "text": "ACUTE", "box": [ 116, 575, 139, 584 ] }, { "text": "CARDIOVASCULAR", "box": [ 142, 574, 205, 583 ] } ], "id": 22 }, { "text": "A221 is insoluble for this procedure. Reference BC30- 38", "box": [ 127, 598, 516, 615 ], "linking": [ [ 22, 23 ] ], "label": "answer", "words": [ { "text": "A221", "box": [ 127, 602, 156, 615 ] }, { "text": "is", "box": [ 160, 602, 175, 615 ] }, { "text": "insoluble", "box": [ 180, 600, 246, 613 ] }, { "text": "for", "box": [ 249, 602, 274, 614 ] }, { "text": "this", "box": [ 277, 602, 308, 614 ] }, { "text": "procedure.", "box": [ 310, 600, 384, 615 ] }, { "text": "Reference", "box": [ 393, 599, 457, 614 ] }, { "text": "BC30-", "box": [ 463, 598, 498, 614 ] }, { "text": "38", "box": [ 499, 599, 516, 612 ] } ], "id": 23 }, { "text": "STORAGE RECOMMENDATIONS", "box": [ 115, 635, 220, 644 ], "linking": [ [ 24, 25 ] ], "label": "question", "words": [ { "text": "STORAGE", "box": [ 115, 635, 150, 644 ] }, { "text": "RECOMMENDATIONS", "box": [ 150, 635, 220, 644 ] } ], "id": 24 }, { "text": "Refrigerate in an amber glass bottle at no more than 8 C.", "box": [ 126, 680, 517, 698 ], "linking": [ [ 24, 25 ] ], "label": "answer", "words": [ { "text": "Refrigerate", "box": [ 126, 682, 202, 698 ] }, { "text": "in", "box": [ 207, 680, 223, 695 ] }, { "text": "an", "box": [ 226, 682, 245, 694 ] }, { "text": "amber", "box": [ 250, 680, 286, 695 ] }, { "text": "glass", "box": [ 290, 680, 326, 696 ] }, { "text": "bottle", "box": [ 330, 680, 374, 695 ] }, { "text": "at", "box": [ 378, 680, 394, 693 ] }, { "text": "no", "box": [ 400, 682, 416, 694 ] }, { "text": "more", "box": [ 420, 682, 451, 694 ] }, { "text": "than", "box": [ 455, 682, 484, 694 ] }, { "text": "8", "box": [ 489, 680, 497, 693 ] }, { "text": "C.", "box": [ 497, 680, 517, 693 ] } ], "id": 25 }, { "text": "COMPOUND SENSITIVE TO", "box": [ 116, 739, 206, 751 ], "linking": [ [ 26, 27 ], [ 26, 28 ], [ 26, 29 ], [ 26, 30 ] ], "label": "header", "words": [ { "text": "COMPOUND", "box": [ 116, 742, 157, 751 ] }, { "text": "SENSITIVE", "box": [ 159, 741, 191, 749 ] }, { "text": "TO", "box": [ 194, 739, 206, 750 ] } ], "id": 26 }, { "text": "☐ AIR", "box": [ 135, 765, 158, 774 ], "linking": [ [ 26, 27 ] ], "label": "question", "words": [ { "text": "☐", "box": [ 135, 765, 144, 774 ] }, { "text": "AIR", "box": [ 146, 765, 158, 774 ] } ], "id": 27 }, { "text": "☐ HEAT", "box": [ 171, 763, 200, 774 ], "linking": [ [ 26, 28 ] ], "label": "question", "words": [ { "text": "☐", "box": [ 171, 765, 179, 773 ] }, { "text": "HEAT", "box": [ 183, 763, 200, 774 ] } ], "id": 28 }, { "text": "☐ MOISTURE", "box": [ 214, 761, 262, 773 ], "linking": [ [ 26, 29 ] ], "label": "question", "words": [ { "text": "☐", "box": [ 214, 762, 225, 773 ] }, { "text": "MOISTURE", "box": [ 226, 761, 262, 773 ] } ], "id": 29 }, { "text": "☐ OTHER", "box": [ 273, 761, 309, 773 ], "linking": [ [ 26, 30 ] ], "label": "question", "words": [ { "text": "☐", "box": [ 273, 762, 285, 773 ] }, { "text": "OTHER", "box": [ 285, 761, 309, 773 ] } ], "id": 30 }, { "text": "SAFETY COMMENTS (SUGGESTED HANDLING PROCEDURE:", "box": [ 119, 790, 312, 802 ], "linking": [], "label": "question", "words": [ { "text": "SAFETY", "box": [ 119, 791, 144, 800 ] }, { "text": "COMMENTS", "box": [ 144, 791, 183, 800 ] }, { "text": "(SUGGESTED", "box": [ 184, 791, 229, 802 ] }, { "text": "HANDLING", "box": [ 229, 790, 266, 799 ] }, { "text": "PROCEDURE:", "box": [ 267, 790, 312, 798 ] } ], "id": 31 }, { "text": "", "box": [ 144, 882, 352, 921 ], "linking": [ [ 5, 32 ] ], "label": "answer", "words": [ { "text": "", "box": [ 144, 882, 243, 921 ] }, { "text": "", "box": [ 247, 886, 278, 906 ] }, { "text": "", "box": [ 281, 886, 352, 909 ] } ], "id": 32 }, { "text": "A - 13", "box": [ 372, 890, 425, 903 ], "linking": [], "label": "other", "words": [ { "text": "A", "box": [ 372, 890, 384, 903 ] }, { "text": "-", "box": [ 390, 890, 398, 901 ] }, { "text": "13", "box": [ 408, 890, 425, 903 ] } ], "id": 33 }, { "text": "", "box": [ 513, 885, 672, 907 ], "linking": [ [ 10, 34 ] ], "label": "answer", "words": [ { "text": "", "box": [ 513, 888, 526, 907 ] }, { "text": "", "box": [ 529, 888, 595, 904 ] }, { "text": "", "box": [ 600, 886, 625, 907 ] }, { "text": "", "box": [ 628, 885, 672, 901 ] } ], "id": 34 }, { "text": "FORM ", "box": [ 652, 904, 700, 915 ], "linking": [], "label": "other", "words": [ { "text": "FORM", "box": [ 652, 904, 672, 913 ] }, { "text": "", "box": [ 674, 904, 679, 915 ] }, { "text": "", "box": [ 679, 905, 700, 914 ] } ], "id": 35 } ] }