context1: Most chemotherapy is delivered intravenously, although a number of agents can be administered orally (e.g., melphalan, busulfan, capecitabine). In some cases, isolated limb perfusion (often used in melanoma), or isolated infusion of chemotherapy into the <strong>liver</strong> or the <strong>lung</strong> have been used. The main purpose of these approaches is to deliver a very high dose of chemotherapy to tumour sites without causing overwhelming systemic damage.
context2: Human synovial fibroblasts have been shown to produce lubricin from the same gene responsible for megakaryocyte stimulating factor (MSF). Lubricin, MSF and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature). The expression of lubricin has also been detected and the protein localised in tendon, meniscus, <strong>lung</strong>, <strong>liver</strong>, heart, bone, ligament, muscle and skin.