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id
string
tokens
sequence
ner_tags
sequence
0
[ "Selegiline", "-", "induced", "postural", "hypotension", "in", "Parkinson", "'", "s", "disease", ":", "a", "longitudinal", "study", "on", "the", "effects", "of", "drug", "withdrawal", "." ]
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1
[ "OBJECTIVES", ":", "The", "United", "Kingdom", "Parkinson", "'", "s", "Disease", "Research", "Group", "(", "UKPDRG", ")", "trial", "found", "an", "increased", "mortality", "in", "patients", "with", "Parkinson", "'", "s", "disease", "(", "PD", ")", "randomized", "to", "receive", "10", "mg", "selegiline", "per", "day", "and", "L", "-", "dopa", "compared", "with", "those", "taking", "L", "-", "dopa", "alone", "." ]
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2
[ "Recently", ",", "we", "found", "that", "therapy", "with", "selegiline", "and", "L", "-", "dopa", "was", "associated", "with", "selective", "systolic", "orthostatic", "hypotension", "which", "was", "abolished", "by", "withdrawal", "of", "selegiline", "." ]
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3
[ "This", "unwanted", "effect", "on", "postural", "blood", "pressure", "was", "not", "the", "result", "of", "underlying", "autonomic", "failure", "." ]
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4
[ "The", "aims", "of", "this", "study", "were", "to", "confirm", "our", "previous", "findings", "in", "a", "separate", "cohort", "of", "patients", "and", "to", "determine", "the", "time", "course", "of", "the", "cardiovascular", "consequences", "of", "stopping", "selegiline", "in", "the", "expectation", "that", "this", "might", "shed", "light", "on", "the", "mechanisms", "by", "which", "the", "drug", "causes", "orthostatic", "hypotension", "." ]
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[ "METHODS", ":", "The", "cardiovascular", "responses", "to", "standing", "and", "head", "-", "up", "tilt", "were", "studied", "repeatedly", "in", "PD", "patients", "receiving", "selegiline", "and", "as", "the", "drug", "was", "withdrawn", "." ]
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[ "RESULTS", ":", "Head", "-", "up", "tilt", "caused", "systolic", "orthostatic", "hypotension", "which", "was", "marked", "in", "six", "of", "20", "PD", "patients", "on", "selegiline", ",", "one", "of", "whom", "lost", "consciousness", "with", "unrecordable", "blood", "pressures", "." ]
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[ "A", "lesser", "degree", "of", "orthostatic", "hypotension", "occurred", "with", "standing", "." ]
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[ "Orthostatic", "hypotension", "was", "ameliorated", "4", "days", "after", "withdrawal", "of", "selegiline", "and", "totally", "abolished", "7", "days", "after", "discontinuation", "of", "the", "drug", "." ]
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[ "Stopping", "selegiline", "also", "significantly", "reduced", "the", "supine", "systolic", "and", "diastolic", "blood", "pressures", "consistent", "with", "a", "previously", "undescribed", "supine", "pressor", "action", "." ]
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[ "CONCLUSION", ":", "This", "study", "confirms", "our", "previous", "finding", "that", "selegiline", "in", "combination", "with", "L", "-", "dopa", "is", "associated", "with", "selective", "orthostatic", "hypotension", "." ]
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[ "The", "possibilities", "that", "these", "cardiovascular", "findings", "might", "be", "the", "result", "of", "non", "-", "selective", "inhibition", "of", "monoamine", "oxidase", "or", "of", "amphetamine", "and", "metamphetamine", "are", "discussed", "." ]
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[ "Further", "studies", "on", "effects", "of", "irrigation", "solutions", "on", "rat", "bladders", "." ]
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[ "Further", "studies", "on", "the", "effects", "of", "certain", "irrigating", "fluids", "on", "the", "rat", "bladder", "for", "18", "hours", "are", "reported", "." ]
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[ "The", "results", "have", "shown", "that", "the", "degradation", "product", "p", "-", "choloroaniline", "is", "not", "a", "significant", "factor", "in", "chlorhexidine", "-", "digluconate", "associated", "erosive", "cystitis", "." ]
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[ "A", "high", "percentage", "of", "kanamycin", "-", "colistin", "and", "povidone", "-", "iodine", "irrigations", "were", "associated", "with", "erosive", "cystitis", "and", "suggested", "a", "possible", "complication", "with", "human", "usage", "." ]
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[ "Picloxydine", "irrigations", "appeared", "to", "have", "a", "lower", "incidence", "of", "erosive", "cystitis", "but", "further", "studies", "would", "have", "to", "be", "performed", "before", "it", "could", "be", "recommended", "for", "use", "in", "urological", "procedures", "." ]
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[ "Effects", "of", "tetrandrine", "and", "fangchinoline", "on", "experimental", "thrombosis", "in", "mice", "and", "human", "platelet", "aggregation", "." ]
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18
[ "Tetrandrine", "(", "TET", ")", "and", "fangchinoline", "(", "FAN", ")", "are", "two", "naturally", "occurring", "analogues", "with", "a", "bisbenzylisoquinoline", "structure", "." ]
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[ "The", "present", "study", "was", "undertaken", "to", "investigate", "the", "effects", "of", "TET", "and", "FAN", "on", "the", "experimental", "thrombosis", "induced", "by", "collagen", "plus", "epinephrine", "(", "EP", ")", "in", "mice", ",", "and", "platelet", "aggregation", "and", "blood", "coagulation", "in", "vitro", "." ]
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[ "In", "the", "in", "vivo", "study", ",", "the", "administration", "(", "50", "mg", "/", "kg", ",", "i", ".", "p", ".", ")", "of", "TET", "and", "FAN", "in", "mice", "showed", "the", "inhibition", "of", "thrombosis", "by", "55", "%", "and", "35", "%", ",", "respectively", ",", "while", "acetylsalicylic", "acid", "(", "ASA", ",", "50", "mg", "/", "kg", ",", "i", ".", "p", ".", ")", ",", "a", "positive", "control", ",", "showed", "only", "30", "%", "inhibition", "." ]
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[ "In", "the", "vitro", "human", "platelet", "aggregations", "induced", "by", "the", "agonists", "used", "in", "tests", ",", "TET", "and", "FAN", "showed", "the", "inhibitions", "dose", "dependently", "." ]
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[ "In", "addition", ",", "neither", "TET", "nor", "FAN", "showed", "any", "anticoagulation", "activities", "in", "the", "measurement", "of", "the", "activated", "partial", "thromboplastin", "time", "(", "APTT", ")", ",", "prothrombin", "time", "(", "PT", ")", "and", "thrombin", "time", "(", "TT", ")", "using", "human", "-", "citrated", "plasma", "." ]
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[ "These", "results", "suggest", "that", "antithrombosis", "of", "TET", "and", "FAN", "in", "mice", "may", "be", "mainly", "related", "to", "the", "antiplatelet", "aggregation", "activities", "." ]
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24
[ "Angioedema", "due", "to", "ACE", "inhibitors", ":", "common", "and", "inadequately", "diagnosed", "." ]
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25
[ "The", "estimated", "incidence", "of", "angioedema", "during", "angiotensin", "-", "converting", "enzyme", "(", "ACE", ")", "inhibitor", "treatment", "is", "between", "1", "and", "7", "per", "thousand", "patients", "." ]
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26
[ "This", "potentially", "serious", "adverse", "effect", "is", "often", "preceded", "by", "minor", "manifestations", "that", "may", "serve", "as", "a", "warning", "." ]
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[ "Cocaine", "-", "induced", "mood", "disorder", ":", "prevalence", "rates", "and", "psychiatric", "symptoms", "in", "an", "outpatient", "cocaine", "-", "dependent", "sample", "." ]
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28
[ "This", "paper", "attempts", "to", "examine", "and", "compare", "prevalence", "rates", "and", "symptom", "patterns", "of", "DSM", "substance", "-", "induced", "and", "other", "mood", "disorders", "." ]
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[ "243", "cocaine", "-", "dependent", "outpatients", "with", "cocaine", "-", "induced", "mood", "disorder", "(", "CIMD", ")", ",", "other", "mood", "disorders", ",", "or", "no", "mood", "disorder", "were", "compared", "on", "measures", "of", "psychiatric", "symptoms", "." ]
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[ "The", "prevalence", "rate", "for", "CIMD", "was", "12", "%", "at", "baseline", "." ]
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31
[ "Introduction", "of", "the", "DSM", "-", "IV", "diagnosis", "of", "CIMD", "did", "not", "substantially", "affect", "rates", "of", "the", "other", "depressive", "disorders", "." ]
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32
[ "Patients", "with", "CIMD", "had", "symptom", "severity", "levels", "between", "those", "of", "patients", "with", "and", "without", "a", "mood", "disorder", "." ]
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33
[ "These", "findings", "suggest", "some", "validity", "for", "the", "new", "DSM", "-", "IV", "diagnosis", "of", "CIMD", ",", "but", "also", "suggest", "that", "it", "requires", "further", "specification", "and", "replication", "." ]
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34
[ "Effect", "of", "fucoidan", "treatment", "on", "collagenase", "-", "induced", "intracerebral", "hemorrhage", "in", "rats", "." ]
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35
[ "Inflammatory", "cells", "are", "postulated", "to", "mediate", "some", "of", "the", "brain", "damage", "following", "ischemic", "stroke", "." ]
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36
[ "Intracerebral", "hemorrhage", "is", "associated", "with", "more", "inflammation", "than", "ischemic", "stroke", "." ]
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37
[ "We", "tested", "the", "sulfated", "polysaccharide", "fucoidan", ",", "which", "has", "been", "reported", "to", "reduce", "inflammatory", "brain", "damage", ",", "in", "a", "rat", "model", "of", "intracerebral", "hemorrhage", "induced", "by", "injection", "of", "bacterial", "collagenase", "into", "the", "caudate", "nucleus", "." ]
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38
[ "Rats", "were", "treated", "with", "seven", "day", "intravenous", "infusion", "of", "fucoidan", "(", "30", "micrograms", "h", "-", "1", ")", "or", "vehicle", "." ]
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39
[ "The", "hematoma", "was", "assessed", "in", "vivo", "by", "magnetic", "resonance", "imaging", "." ]
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40
[ "Motor", "behavior", ",", "passive", "avoidance", ",", "and", "skilled", "forelimb", "function", "were", "tested", "repeatedly", "for", "six", "weeks", "." ]
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[ "Fucoidan", "-", "treated", "rats", "exhibited", "evidence", "of", "impaired", "blood", "clotting", "and", "hemodilution", ",", "had", "larger", "hematomas", ",", "and", "tended", "to", "have", "less", "inflammation", "in", "the", "vicinity", "of", "the", "hematoma", "after", "three", "days", "." ]
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[ "They", "showed", "significantly", "more", "rapid", "improvement", "of", "motor", "function", "in", "the", "first", "week", "following", "hemorrhage", "and", "better", "memory", "retention", "in", "the", "passive", "avoidance", "test", "." ]
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[ "Acute", "white", "matter", "edema", "and", "eventual", "neuronal", "loss", "in", "the", "striatum", "adjacent", "to", "the", "hematoma", "did", "not", "differ", "between", "the", "two", "groups", "." ]
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[ "Investigation", "of", "more", "specific", "anti", "-", "inflammatory", "agents", "and", "hemodiluting", "agents", "are", "warranted", "in", "intracerebral", "hemorrhage", "." ]
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[ "Recurarization", "in", "the", "recovery", "room", "." ]
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46
[ "A", "case", "of", "recurarization", "in", "the", "recovery", "room", "is", "reported", "." ]
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[ "Accumulation", "of", "atracurium", "in", "the", "intravenous", "line", "led", "to", "recurarization", "after", "flushing", "the", "line", "in", "the", "recovery", "room", "." ]
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[ "A", "respiratory", "arrest", "with", "severe", "desaturation", "and", "bradycardia", "occurred", "." ]
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49
[ "Circumstances", "leading", "to", "this", "event", "and", "the", "mechanisms", "enabling", "a", "neuromuscular", "blockade", "to", "occur", ",", "following", "the", "administration", "of", "a", "small", "dose", "of", "relaxant", ",", "are", "discussed", "." ]
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[ "The", "haemodynamic", "effects", "of", "propofol", "in", "combination", "with", "ephedrine", "in", "elderly", "patients", "(", "ASA", "groups", "3", "and", "4", ")", "." ]
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[ "The", "marked", "vasodilator", "and", "negative", "inotropic", "effects", "of", "propofol", "are", "disadvantages", "in", "frail", "elderly", "patients", "." ]
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[ "We", "investigated", "the", "safety", "and", "efficacy", "of", "adding", "different", "doses", "of", "ephedrine", "to", "propofol", "in", "order", "to", "obtund", "the", "hypotensive", "response", "." ]
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[ "The", "haemodynamic", "effects", "of", "adding", "15", ",", "20", "or", "25", "mg", "of", "ephedrine", "to", "200", "mg", "of", "propofol", "were", "compared", "to", "control", "in", "40", "ASA", "3", "/", "4", "patients", "over", "60", "years", "presenting", "for", "genito", "-", "urinary", "surgery", "." ]
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[ "The", "addition", "of", "ephedrine", "to", "propofol", "appears", "to", "be", "an", "effective", "method", "of", "obtunding", "the", "hypotensive", "response", "to", "propofol", "at", "all", "doses", "used", "in", "this", "study", "." ]
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[ "However", ",", "marked", "tachycardia", "associated", "with", "the", "use", "of", "ephedrine", "in", "combination", "with", "propofol", "occurred", "in", "the", "majority", "of", "patients", ",", "occasionally", "reaching", "high", "levels", "in", "individual", "patients", "." ]
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56
[ "Due", "to", "the", "risk", "of", "this", "tachycardia", "inducing", "myocardial", "ischemia", ",", "we", "would", "not", "recommend", "the", "use", "in", "elderly", "patients", "of", "any", "of", "the", "ephedrine", "/", "propofol", "/", "mixtures", "studied", "." ]
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[ "Gemcitabine", "plus", "vinorelbine", "in", "nonsmall", "cell", "lung", "carcinoma", "patients", "age", "70", "years", "or", "older", "or", "patients", "who", "cannot", "receive", "cisplatin", "." ]
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58
[ "Oncopaz", "Cooperative", "Group", "." ]
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59
[ "BACKGROUND", ":", "Although", "the", "prevalence", "of", "nonsmall", "cell", "lung", "carcinoma", "(", "NSCLC", ")", "is", "high", "among", "elderly", "patients", ",", "few", "data", "are", "available", "regarding", "the", "efficacy", "and", "toxicity", "of", "chemotherapy", "in", "this", "group", "of", "patients", "." ]
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