evidence: the therapy including sodium clodronate was the most beneficial in terms of percentage improvement in VAS pain score (10.1% improvement versus group 1; 8.8% improvement versus group 2
intervention: group 1, treated with an injection of hyaluronic acid alone (66 mg) into each knee; group 2, treated with an injection of hyaluronic acid (49.5 mg) plus diclofenac sodium (5 mg) into each knee;
comparator: group 3, treated with an injection of hyaluronic acid (49.5 mg) plus sodium clodronate (5 mg) into each knee
outcome: erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)