evidence: Considering this subgroup of patients, the reintubation rates related to NIV failure were significantly lower in the study group when compared with controls; two patients (6%) versus 13 (33%); P < 0.05, respectively.
intervention: (B) the Mechanical insufflation-exsufflation (MI-E) extubation protocol (study group)
comparator: (A) a conventional extubation protocol (control group)
outcome: the reintubation rates related to noninvasive ventilation (NIV) failure