evidence: The median time to first postsurgical use of rescue opioid medication was significantly longer with liposome bupivacaine (9.3 hours) compared with bupivacaine HCl (6.4 hours; P = 0.013) and placebo (3.6 hours; P < 0.0001).
intervention: liposome bupivacaine
comparator: bupivacaine HCl and placebo
outcome: The median time to first postsurgical use of rescue opioid medication