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์ˆ˜๊ณ  ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค. ์˜์ƒ๊ฒ€์‚ฌ์ด์ƒ์œผ๋กœ 2019.06.12 ๋ณธ์›๋‚ด์›ํ•˜์—ฌ ์ดฌ์˜ํ•œ CT๊ฒ€์‚ฌ์ƒ R/O Lung cancer in RLL ์œผ๋กœ ์ดํ›„ ๋ณธ์› f/u loss ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ์ดํ›„ ํƒ€๋ณ‘์›์—์„œ 9๊ฐœ์›”๊ฐ„ f/u(์กฐ์ง๊ฒ€์‚ฌ ์‹œํ–‰ํ•˜์ง€ ์•Š์Œ) ํ›„ 2023.05.24 ๋ณธ์› ์žฌ๋‚ด์›ํ•˜์—ฌ 2023.06.14 ์‹œํ–‰ํ•œ ์กฐ์ง๊ฒ€์‚ฌ์ƒ lung cancer ํ™•์ธ๋œ ๋ถ„์˜ ์ดˆ์ง„์ผ์„ 2019.06.12 vs 2023.05.24 ์ค‘ ์ดˆ์ง„์ผ ์„ ์ • ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
์ดˆ์ง„์ผ์€ ๋ณธ์› ์žฌ๋‚ด์›์ผ์ธ 2023.05.24.๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์ดˆ์ง„์ผ ๊ด€๋ จํ•˜์—ฌ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.ํƒ€๋ณ‘์› ๊ฐ‘์ƒ์„  ์„ธ์นจ๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์ƒ suspicious papillary carcinoma๋กœ, ์ˆ˜์ˆ ์œ„ํ•ด ์ €ํฌ ๋ณ‘์›์œผ๋กœ ๋‚ด์›ํ•  ๋•Œ ํƒ€๋ณ‘์›์—์„œ C73 ๊ฐ‘์ƒ์„ ์•”์œผ๋กœ ์ง„๋‹จ๋ฐ›๊ณ  ์˜ค๋Š” ๊ฒฝ์šฐ๊ฐ€ ์žˆ์Šต๋‹ˆ๋‹ค.์ด๋Ÿด ๊ฒฝ์šฐ ์ดˆ์ง„์ผ์„ ํƒ€๋ณ‘์›์—์„œ ์•”์ง„๋‹จ์„ ๋ฐ›์•˜์Œ์—๋„ ๊ฒฐ๊ณผ ์ƒ suspicious์ด๊ธฐ ๋•Œ๋ฌธ์— ์ €ํฌ๋ณ‘์› ์ฒ˜์Œ ๋‚ด์›ํ•œ ๋‚ ์งœ๋กœ ๋ถ€์—ฌํ•ด์•ผํ• ์ง€, ์•„๋‹ˆ๋ฉด ์˜๋ฃŒ์ง„์˜ ํŒ๋‹จ์— ๋”ฐ๋ผ ์•”์œผ๋กœ ๋ณด์•˜๊ธฐ๋•Œ๋ฌธ์— ํƒ€๋ณ‘์› ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์ง€์— ์ ํžŒ ๋‚ ์งœ๋กœ ์ดˆ์ง„์ผ์„ ๋ถ€์—ฌํ•ด์•ผํ•  ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
ํƒ€๋ณ‘์›์—์„œ ์•”์œผ๋กœ ์ง„๋‹จ๋œ ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์ง€ ๋‚ ์งœ๋ฅผ ์ดˆ์ง„์ผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.(suspicious ๋Š” ์•”์œผ๋กœ ๊ฐ„์ฃผํ•˜๋Š” ์šฉ์–ด์ž„ SEER 2000 ์ฑ… p.15 ์ฐธ๊ณ )
์ด์ „์— 1๋ฒˆ ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์— ๋Œ€ํ•ด ์กฐ์ง1๋ฒˆ ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์˜ ๊ฒฝ์šฐ, ์„œ๋กœ ๋‹ค๋ฅธ ์กฐ์ง์†Œ๊ฒฌ๊ตฐ(neuroendocrine tumor, squcc)์ž„์—๋„ ๋†’์€์ฝ”๋“œ๋กœ ๋“ฑ๋กํ•˜๋„๋ก ๋‹ต๋ณ€์„ ๋ฐ›์•˜์Šต๋‹ˆ๋‹ค. ๊ทธ ์ดํ›„ ์ˆ˜์ˆ ์„ ์‹œํ–‰ํ•˜์˜€๊ณ , 2๋ฒˆ๊ณผ ๊ฐ™์€ ์ˆ˜์ˆ ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค. 2๋ฒˆ ์ˆ˜์ˆ ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ๋ถ€์œ„๋Š” supraglottis๋กœ ๋™์ผํ•˜๋‚˜, ์„œ๋กœ ํŽธ์ธก์„ฑ&TNM๋„ ๋‹ค๋ฅด๊ณ , ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋„ 2๊ฐœ์ž…๋‹ˆ๋‹ค. ๊ทธ๋ž˜๋„ ์•„๋ž˜ ์ผ€์ด์Šค๋Š” 1๊ฐœ๋กœ ๋“ฑ๋กํ•ด์•ผ ํ• ์ง€, ๋˜๋Š” ๋”๋ธ”์•”์œผ๋กœ ๋ณด์•„์•ผํ• ์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค. -------------------------------------------1) 2023-11-15 ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผSupraglottis, "epiglottis laryngeal surface"(frozen No.1 and No.1), laryngeal microsurgery; Mixed neuroendocrine tumor, grade 1, and squamous cell carcinoma, well differentiated (SEE NOTE) with 1. mitotic count: <1/10HPF (in neuroendocrine tumor area) 2. lymphovascular invasion: not identified> 2024.01.09 ์•”๋“ฑ๋ก ๊ต์œก์„ผํ„ฐ ๋‹ต๋ณ€ : ๋†’์€์ฝ”๋“œ์ธ M8246/3 Neuroendocrine carcnom๋กœ ๋“ฑ๋ก ----------------------------------------2) 2023-12-12 ์ˆ˜์ˆ ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผLarynx, bilateral, partial laryngectomy; 1. Large cell neuroendocrine carcinoma in the background of atypical carcinoid Resection after radiation or chemotherapy : no 1) Primary tumor site : supraglottis ; laryngeal surface of epiglottis 2) Tumor Laterality : right 3) Tumor Size - Greatest dimension (centimeters): 2.6cm - Additional dimensions (centimeters): 1.8cm 4) Limited to larynx 5) Surgical resection margin : anterior resection margin(preepiglottic side) involved by tumor (safety margin: inferior: <0.1cm, right lateral: <0.1cm, superior: 0.1cm, left lateral: 1.2cm) 6) Lymph node metastasis : metastasis in 7 out of 44 lymph nodes (7/44) Rt.neck level II LN(2/18), Rt.neck level III LN(3/7), Rt.neck level IV LN(2/19) (1) Laterality of lymph nodes involved Ipsilateral (2) The greatest tumor dimension: 0.5cm (3) Extranodal Extension (ENE): present (1mm) 7) Lymphatic invasion : present 8) Venous invasion : not identified 9) Perineural invasion : present 10) Pathologic staging: pT3N3b (AJCC 8th edition) 2. Squamous cell carcinoma, non-keratinizing, moderately differentiated 1) Primary tumor site : supraglottis ; false vocal cord 2) Tumor Laterality : left 3) Tumor Size - Greatest dimension (centimeters): 0.9cm - Additional dimensions (centimeters): 0.4cm 4) Limited to larynx 5) Surgical resection margin : free from tumor (safety margin: inferior: 0.3cm, anterior: 0.3cm, left lateral: 0.4cm, superior: 1.0cm, right lateral: 2.1cm) 6) Lymph node metastasis : metastasis in 8 out of 51 lymph nodes (8/51) Lt.neck level IA LN(0/3), Lt.neck level IB LN(0/4), Lt.neck level II LN(3/20), Lt.neck level IIB LN(0/7), Lt.neck level III LN(1/6), Lt.neck level IV LN(3/7), Lt.neck level V LN(1/4) (1) Laterality of lymph nodes involved Ipsilateral (2) The greatest tumor dimension: 0.9cm (3) Extranodal Extension (ENE): not identified 7) Lymphatic invasion : not identified 8) Venous invasion : not identified 9) Perineural invasion : not identified 10) Pathologic staging: pT1N2b (AJCC 8th edition)
๋‹ต1) ์ผ€์ด์Šค 1์˜ ๊ฒฝ์šฐ๋Š” ์ข…์–‘์ด ํ•˜๋‚˜๋ฟ์ด๋ผ ๋‹ค์ค‘์›๋ฐœ์•” ๊ทœ์น™์„ ์ ์šฉํ•  ์ˆ˜ ์—†์Šต๋‹ˆ๋‹ค. ๋ณต์žกํ•œ ์ง„๋‹จ๋ช… ๊ทœ์น™์— ๋”ฐ๋ผ ์ฝ”๋”ฉ์„ ํ•ด์•ผํ•˜๊ณ , ๋”ฐ๋ผ์„œ ๊ธฐ์กด ๋‹ต๋ณ€๋Œ€๋กœ '๋†’์€์ฝ”๋“œ์ธ M8246/3 Neuroendocrine carcnom'๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.๋‹ต2) ์ผ€์ด์Šค 2์˜ ๊ฒฝ์šฐ๋Š” ์ข…์–‘์ด ๋‘๊ฐœ์ด์ƒ์ธ ๊ฒฝ์šฐ๋ผ ๋‹ค์ค‘์›๋ฐœ์•” ๊ทœ์น™์„ ์ ์šฉํ•ฉ๋‹ˆ๋‹ค. Tumor1(right): M8013/3(Large cell neuroendocrine carcinoma)= 5๋ฒˆ ๊ทธ๋ฃน์— ํ•ด๋‹น Tumor2(left): M8072/3(Squamous cell carcinoma, nonkeratinizing, NOS)= 1๋ฒˆ ๊ทธ๋ฃน์— ํ•ด๋‹น ์ด ์ผ€์ด์Šค๋Š” M8072/3 ์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค. (โˆต ๋‘ ์ข…์–‘์ด ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์€ ์•„๋‹ˆ๋‚˜ (5)๋ฒˆ ๊ทธ๋ฃน์€ 'Unspecified' ๊ทธ๋ฃน์ด๊ธฐ ๋•Œ๋ฌธ)
์ฒ™์ถ”์ข…์–‘๋“ฑ๋ก ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.MRI SPINE 9/7 CSF space at L2/3 level : - A small IDEM nodular lesion, 0.5cm, R/O neurogenic tumor.MRI SPINE 10/23. CSF space at L2/3 level :- A 4x2mm sized small IDEM nodular lesion with well enhancement--> R/O neurogenic tumor. A large round T1 low, T2 high enhancing lesion in L1 VB.-> R/O atypical hemangioma. Small another typical hemangioma in L1 VB.๋ผ๊ณ  ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค. SPINE ์ชฝ์˜ hemangioma ๊ฐ€ ๋“ฑ๋ก ๊ฐ€๋Šฅํ•œ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. C70.1 / M9120/0๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋ณด๋‚ด์ฃผ์‹  ๊ฒฐ๊ณผ๋งŒ์œผ๋กœ๋Š” ์›๋ฐœ๋ถ€์œ„๋ฅผ ํŠน์ •ํ•  ์ˆ˜ ์—†์Šต๋‹ˆ๋‹ค.์ง„๋‹จ๋‚ด๋ฆฐ ์ฃผ์น˜์˜์—๊ฒŒ ๋ฌธ์˜ํ•˜์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
01/11 Liver Bx -> carcinoma with signet ring cell -like appearance and neuroendocrine differentiationPrimary hepatic signet ring cell neuroendocrine tumor ์˜ ๋ชฐํด๋กœ์ง€๋Š” M8574/3 ์œผ๋กœ ๋ถ€์—ฌํ•ด์•ผํ• ์ง€ ๊ณ ๊ฒฌ์ฃผ์‹œ๋ฉด ๊ฐ์‚ฌํ•˜๊ฒ ์Šต๋‹ˆ๋‹ค.
M8574/3(Carcinoma with neuroendocrine differentiation) ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
.ํƒ€๋ณ‘์› ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๊ฐ€ ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.Skin, anterior neck, excisional biopsy; Lymphomatoid papulosis, subtype A [ ADDITIONAL STUDIES ]The results of immunohistochemical staining; CD4 : positive CD8 : negative CD30 : positive TCRฮด : negative CD20 : positive์™ธ๋ž˜ ๊ธฐ๋ก์ƒ ํ•ด๋‹น ๋ณ‘๋ณ€์€ ๋ถ„๋ฅ˜ ์ƒ indolent cutaneous lymphoma ์— ์†ํ•˜๊ธฐ๋Š” ํ•˜๋‚˜, ๋ณ„๋‹ค๋ฅธ ์น˜๋ฃŒ ์—†์ด ํ˜ธ์ „๋˜๊ธฐ๋„ ๋‹ค์‹œ ์ฆ๊ฐ€ํ•˜๊ธฐ๋„ ํ•œ๋‹ค ๋ผ๋Š” ๋‚ด์šฉ์ด ์žˆ์Šต๋‹ˆ๋‹ค.KCD์—์„œ๋Š” C86.6์ธ๋ฐ์š”.ICD-O-3 2nd์—์„œ๋Š” M9718/1 Lymphomatoid papulosis(C44.-)๋กœ ํ™•์ธ์ด ๋ฉ๋‹ˆ๋‹ค.M9718/3์— Primary cutaneous CD30 positive T-cell lymphoproliferative disorder๋„ ์žˆ๋Š”๋ฐ 1. subtype์— ๋”ฐ๋ผ์„œ /1๊ณผ /3์œผ๋กœ ๊ตฌ๋ถ„ํ•  ์ˆ˜ ์žˆ๋Š”์ง€2. ๋ฉด์—ญ๋ณ‘๋ฆฌ์— CD30 positive๊ฐ€ ํ™•์ธ๋˜๋‹ˆ /3์œผ๋กœ ๋ถ€์—ฌํ•  ์ˆ˜ ์žˆ๋Š”์ง€๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.
ICD-O-3 2nd ๊ธฐ์ค€์œผ๋กœ ํ•ด๋‹น ์ผ€์ด์Šค๋Š” M9718/1 Lymphomatoid papulosis(C44.-) ๋กœ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
. M-code ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ^^ Nasal cavity Cancer๋กœ nasal OP ํ›„ ๋‚˜์˜จ ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค. Nasal cavity, right, excision: Hybrid carcinoma of myoepithelial carcinoma and squamous cell carcinoma (see note) with involved excisional margin ์œ„ ๊ฒฐ๊ณผ์™€ ๊ฐ™์€ ์กฐํ•ฉ์ฝ”๋“œ๊ฐ€ ์—†์–ด์„œ M8982/3 (Myoepithelial carcinoma) , M8070/3(Squamous cell carcinoma, NOS) ๊ฐ๊ฐ ๋“ฑ๋ก์„ ํ•˜๋ฉด๋ ๊นŒ์š” ? ๋‹ต๋ณ€ ๋ฏธ๋ฆฌ ๊ฐ์‚ฌ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ^^
(see note) ๋‚ด์šฉ ๊ฐ™์ด ์ฒจ๋ถ€ํ•ด์ฃผ์„ธ์š”.
,์›๋ฐœ๋ถ€์œ„ ๋ฐ ์กฐ์งํ•™์ ์ง„๋‹จ๋ช… ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.Colon and rectum์— polypectomy๋ฅผ ์‹œํ–‰ํ•˜์˜€๊ณ  ์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.Descending(Is, 6mm): Tubular adenoma, focal high grade dysplasia Sigmoid(Is, 5mm): Tubulovillous adenoma, focal high grade dysplasia 1) Descending๊ณผ sigomoid๋Š” ํ•ด๋ถ€ํ•™์ ์œผ๋กœ ์ธ์ ‘ํ•œ ๋ถ€์œ„์ด๋ฏ€๋กœ ๊ฒฐ์žฅ์˜ ์ค‘๋ณต๋ณ‘๋ณ€์ธ C188์„ ์›๋ฐœ๋กœ ๋ถ€์—ฌํ•˜๊ณ  2) ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์€Tubular adenoma, focal high grade dysplasia 82112 ์™€Tubulovillous adenoma, focal high grade dysplasia 82632 ์ค‘ ๋” ๋†’์€ ์ฝ”๋“œ์ธ 82632๋ฅผ ๋ถ€์—ฌํ•˜๋Š”๊ฒŒ ๋งž์„๊นŒ์š”?
C189 M8263/2 ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.ํ•˜๋‚˜์˜ ์ข…์–‘์ด ๋‘˜ ์ด์ƒ์˜ ๋ฒ”์ฃผ ๋˜๋Š” ๊ฒฝ๊ณ„์— ๋ฐœ์ƒํ•œ ๊ฒฝ์šฐ์— overlapping code(_.8)๋ฅผ ์‚ฌ์šฉํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.ํ•ด๋‹น ์ผ€์ด์Šค๋Š” ์ข…์–‘์ด ๊ฐ๊ฐ 2๊ฐœ์ธ ๊ฒฝ์šฐ๋ผ overlapping code ๋กœ ์ฝ”๋”ฉํ•  ์ˆ˜ ์—†์Šต๋‹ˆ๋‹ค.(์•”๋“ฑ๋ก์ง€์นจ์„œ 2012, p.32. ๊ทœ์น™C ์ฐธ๊ณ )
, ์ˆ˜๊ณ ๊ฐ€ ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค. ------------------------------------------------------------------------1HE)Diagnosis: Pancreas, head, EUS-FNA biopsy: Atypical-looking glands with papillary architecture ; possibility of Intraductal papillary mucinous neoplasm (IPMN)------------------------------------------------------------------------1HE)Diagnosis: Bile duct, PTBD-guided biopsy: Adenocarcinoma, well-differentiated------------------------------------------------------------------------#1. Pancreas head cancer (2023/8) - invasion of duodenum & EHD - Bx (adenocarcinoma, WD) ------------------------------------------------------------------------์œ„ ์†Œ๊ฒฌ์ผ ๊ฒฝ์šฐ -> C250(Pancreas head cancer) -> M8453/3(Intraductal papillary mucinous neoplasm with an associated invasive carcinoma(C25._)) -> seer 2 -> ๋ถ„ํ™”๋„ well-differentiated ๋กœ ์•”๋“ฑ๋ก ํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค, ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
์›๋ฐœ๋ถ€์œ„๊ฐ€ pancreas ์ด๊ณ , ์นจ๋ฒ”๋ถ€์œ„๊ฐ€ duodenum ์ธ ๊ทผ๊ฑฐ(invasion of duodenum & EHD)๊ฐ€ ํ™•์ธ ๊ฐ€๋Šฅํ•œ ์˜์ƒ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๋ฅผ ์ฒจ๋ถ€ํ•ด์ฃผ์„ธ์š”.์›๋ฐœ๋ถ€์œ„์— ๋”ฐ๋ผ ์•”๋“ฑ๋ก์ด ๋‹ฌ๋ผ์งˆ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.
์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.Stomach, lower body antrum : Neuroendocrine dysplasia in mucosa 1. NET์™€ ๊ฐ™์€๊ฒƒ์ธ๊ฐ€์š”?2. ์ œ์ž๋ฆฌ์•”์ธ๊ฐ€์š”?3. ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ๋งž๋‚˜์š”?
ํ•ด๋‹น ์ง„๋‹จ์€ ์•”๋“ฑ๋ก๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
Psudomyxoma peritonei ์†Œ๊ฒฌ์œผ๋กœ lap.exploration ์‹œํ–‰ํ•˜์‹  ๋ถ„์œผ๋กœBx์ƒAppendix, appendectomy: Low grade appendical mucinous neoplasm(pTNM, pT4a, pM1b) consisten with psudomyxoma peritoneiOvary tissue biopsy: Low grade appendical mucinous neoplasm, MetasaticOmentum biopsy: Low grade appendical mucinous neoplasm, Metastatic์œผ๋กœ pseudomyxoma peritonei ์ง„๋‹จ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.Appendix๋Š” M8480/1์— ํ•ด๋‹นํ•˜๋Š”๋ฐpseudomyxoma peritonei์˜ ์›๋ฐœ์•”์œผ๋กœ ๋“ฑ๋ก ๊ฐ€๋Šฅํ•œ๊ฐ€์š”?
์ž๋ฌธ์˜๊ฒฌ์€ ์•„๋ž˜์™€ ๊ฐ™์Šต์‹ ๋‹ค. ๋งน์žฅ์˜ ์ ์•ก์ข…์–‘์— ๋Œ€ํ•˜์—ฌ ์™„์ „ํžˆ ์ •๋ฆฝ๋œ ๊ฒƒ์€ ์•„๋‹ˆ๋ผ ์• ๋งคํ•˜๊ธฐ๋Š” ํ•ฉ๋‹ˆ๋‹ค.๊ทธ๋Ÿฐ๋ฐ LAMN์˜ ๊ฒฝ์šฐ๋Š” ๋”์šฑ ์˜๊ฒฌ์ด ๊ฐˆ๋ผ์ง€๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ํŠนํžˆ ๋Œ€๋ถ€๋ถ„ ๋ณต๋ง‰์ „์ด์™€ ์›๋ฐœ๋ถ€์œ„์˜ grade๊ฐ€ ๋น„์Šทํ•œ๋ฐ, ๋‹ค๋ฅผ ๊ฒฝ์šฐ ๊ฐ๊ฐ grading์„ ํ•˜๋ผ๊ณ  ๋˜์–ด ์žˆ์Šต๋‹ˆ๋‹ค.๋˜ํ•œ ๋ณต๋ง‰ํŒŒ์ข…์ด ์žˆ๋Š” ๊ฒฝ์šฐ ๊ทธ๊ฒƒ๋งŒ์œผ๋กœ๋„ ์ƒ˜์•”์ข…์— ์ค€ํ•˜๋Š” 8480/3์ด๋‚˜ ๋ณต๋ง‰ํŒŒ์ข…์„ ๊ณ ๋ คํ•˜์—ฌ 8480/6์œผ๋กœ ํ•ด์•ผํ•œ๋‹ค๋Š” ์˜๊ฒฌ๊ณผ destructive stromal invasion์ด ์—†๋‹ค๋ฉด ์˜ˆํ›„๊ฐ€ ์ข‹์œผ๋ฏ€๋กœ ๋ณต๋ง‰ํŒŒ์ข…์ด ์žˆ์–ด๋„ 8480/1๋กœ ํ•ด์•ผํ•œ๋‹ค๋Š” ์˜๊ฒฌ์ด ์žˆ์Šต๋‹ˆ๋‹ค.์ž๋ฌธ์˜๊ฒฌ์„ ํ† ๋Œ€๋กœ ๋ณ‘๋ฆฌ์˜ํ•œํ…Œ ๋ฌธ์˜ํ›„ ์ง„๋‹จ์—ฌ๋ถ€๋ฅผ ํ™•์ธํ•ด์ฃผ์„ธ์š”.
5-8. Left mid to lower mass:- Histologic type: Papillary carcinoma, classic (#5-8)- Pathologic staging (pTNM) [AJCC 8th ed.] pT1b (Tumor >1 cm but โ‰ค2 cm, limited to the thyroid) pN0 (No evidence of locoregional lymph node metastasis) - Tumor size: 16 mm- Margin: Uninvolved by tumor cells - Multiplicity: Not identified - Bilaterality: Cannot be assessed - Tumor encapsulation: Not identified - Thyroid capsular invasion: Not identified - Extrathyroidal extension: Not identified - Lymphatic invasion: Not identified - Angioinvasion: Not identified- Additional findings: Not identified 1. Pretracheal LN (0/1), 2. Prelaryngeal LN (fibroadipose tissue), 3. Left paratracheal LN (0/3): Uninvolved by tumor cells- No. of lymph nodes examined: 4- No. of lymph nodes involved: 0- Parathyroid gland: Present (#3)4. Margin: Uninvolved by tumor cells Immunohistochemical stains:NTRK (Negative) on block #5SEER 1,2 ๋ฒˆ ์–ด๋Š๊ฒƒ์œผ๋กœ ์ค˜์•ผ ํ•˜๋‚˜์š”?
SEERCODE '1' ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค. (๊ทผ๊ฑฐ: limited to the thyroid)
,Breast, left, partial mastectomy ์กฐ์ง๊ฒฐ๊ณผ, MIXED INVASIVE BREAST CARCINOMA, NST (70 %) and MUCINOUS CARCINOMA (30 %). 1) Tumor size : 1.5 x 1.3 x 1.2 cm. 2) Histologic grade : II. 3) Nuclear grade : Intermediate nuclear grade. 4) Extensive intraductal component (EIC): POSITIVE. 5) Microcalcification : PRESENT. 6) Lymphovascular invasion : PRESENT. 7) Perineural invasion : Not identified. 8) Mitotic count : < 8 / 10 HPF (x400).๋กœ ํ™•์ธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.์ด ๊ฒฝ์šฐ M8523/3 Infiltrating duct mixed with other types of carcinoma ๋กœ ์•”๋“ฑ๋กํ•˜๋Š”๊ฒƒ์ด ๋งž์„์ง€, ์•„๋‹ˆ๋ฉด M8500/3 INVASIVE BREAST CARCINOMA, NST ์•”๋“ฑ๋กํ•˜๋Š”๊ฒƒ์ด ๋งž์„์ง€ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M8523/3 Infiltrating duct and mucinous carcinoma(C50._) ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
ovary mass ์†Œ๊ฒฌ๋ณด์—ฌ ์ž…์›ํ•˜์—ฌ ์‹œํ–‰ํ•œ Pelvic MRI ์ƒ, malignant omental mass ์žˆ์–ด omentum(Rt), needle Bx ์‹œํ–‰ํ•˜์˜€์Šต๋‹ˆ๋‹ค. Bx ํŒ๋…๊ฒฐ๊ณผ, Metastatic carcinoma. Favor high grade serous carcinoma from ovary ๋ณด๊ณ ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.ICD-O-3 2nd ๊ฐœ์ •ํŒ์— M8461/3 High grade serous carcinoma ๊ฐ€ ์‹ ์„ค๋˜์—ˆ๋Š”๋ฐ, M8461/6 Metastatic high grade serous carcinoma ์ฝ”๋“œ๋ฅผ ์ถ”๊ฐ€ํ•˜์—ฌ ์‚ฌ์šฉํ•ด๋„ ๋ ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. (์•”๋“ฑ๋ก ์‹œ ์ „์ด๋ถ€์œ„ M์ฝ”๋“œ๋ฅผ ์ž…๋ ฅํ•˜์ง€ ์•Š์ง€๋งŒ, ํ‡ด์›ํ™˜์ž ์ฝ”๋”ฉํ•  ๋•Œ M8461/6 ์ฝ”๋“œ๊ฐ€ ์กด์žฌํ•˜์ง€ ์•Š์•„์„œ M8461/6 ์ฝ”๋“œ ์‚ฌ์šฉ ๊ฐ€๋ถ€์— ๋Œ€ํ•ด ๋‹ต๋ณ€ํ•ด์ฃผ์‹œ๋ฉด ๊ฐ์‚ฌํ•˜๊ฒ ์Šต๋‹ˆ๋‹ค:)
์ค‘์•™์•”๋“ฑ๋ก๋ณธ๋ถ€์—์„œ๋Š” ์•”๋“ฑ๋ก ๊ด€๋ จ ์งˆ๋ฌธ์— ๋Œ€ํ•ด ๋‹ต๋ณ€๋“œ๋ฆฌ๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์งˆ๋ณ‘๋ถ„๋ฅ˜์— ๊ด€ํ•ด์„œ๋Š” ๋Œ€ํ•œ๋ณด๊ฑด์˜๋ฃŒ์ •๋ณด๊ด€๋ฆฌ์‚ฌํ˜‘ํšŒ์˜ ์ฝ”๋”ฉํด๋ฆฌ๋‹‰์— ๋ฌธ์˜ํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก ๋ˆ„๋ฝ๊ฑด์„ ๊ฒ€ํ† ํ•˜๋‹ค๊ฐ€ ์งˆ๋ฌธ์ด ์žˆ์–ด์„œ Q&A ๋ฅผ ๋‚จ๊น๋‹ˆ๋‹ค. 2014๋…„ ์ง€์นจ์— ์˜ํ•˜๋ฉด, ์›๋ฐœ๋ถ€์œ„๊ฐ€ C15 C16 C18 C19 C20 C22 C23.9 C24.1 C25 ์— ๋Œ€ํ•ด์„œ๋Š”์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์ด High grade dysplasia/neoplasia ์ธ ๊ฒฝ์šฐ ํ–‰ํƒœ์ฝ”๋“œ /2 ๋กœ ์ธ์ •ํ•œ๋‹ค๊ณ  ๋˜์–ด์žˆ๊ณ , ํ•ด๋‹น ๊ฒฝ์šฐ ์•”๋“ฑ๋ก์„ ํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์งˆ๋ฌธ 1) ์›๋ฐœ๋ถ€์œ„๊ฐ€ C15 C16 C18 C19 C20 C22 C23.9 C24.1 C25 ์— ํ•ด๋‹นํ•˜๊ณ ,์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์ด Epithelial dysplasia, high grade ๋ผ๋ฉด์•”๋“ฑ๋ก์„ ํ•ด์•ผํ•˜๋Š” ๋Œ€์ƒ์ธ์ง€์งˆ๋ฌธ 2) ์กฐ์ง๋ณ‘๋ฆฌ๊ฒ€์‚ฌ์— Epithelial dysplasia, high grade ์ด์ง€๋งŒ ์ฃผ์น˜์˜๊ฐ€ benign ์œผ๋กœ ๊ฐ„์ฃผํ•˜๋Š” ๊ฒฝ์šฐ์—๋„ ์•”๋“ฑ๋ก์„ ํ•ด์•ผํ•˜๋Š”์ง€์ƒ๊ธฐ ๋‘ ์งˆ๋ฌธ์— ๋Œ€ํ•œ ๋‹ต๋ณ€๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. * 22๋…„๋„์— ์›๋ฐœ๋ถ€์œ„๊ฐ€ stomach ์ด๊ณ , ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์ด Epithelial dysplasia, high grade์ธ ๊ฒฝ์šฐ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ธ์ง€ ์—ฌ๋ถ€์— ๋Œ€ํ•ด ์งˆ์˜๋ฅผ ๋‚จ๊ฒผ์—ˆ๋‹ค๊ฐ€ "'high grade dysplasia'์™€ ๋™์ผํ•˜๊ฒŒ ๋ณผ ์ˆ˜ ์žˆ๋Š”์ง€ ์ฃผ์น˜์˜ ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค." ๋‹ต๋ณ€์„ ๋ฐ›์€ ์ ์ด ์žˆ์Šต๋‹ˆ๋‹ค.( ์ž‘์„ฑ์ผ 2022.02.08. ์ž‘์„ฑ์ž ์†กํ˜„์ • )๊ทธ๋Ÿฌ๋‚˜, ๊ทธ ์ดํ›„ ์งˆ์˜ ๊ฑด๋“ค์˜ ๋‹ต๋ณ€์„ ๋ณด์•„ํ•˜๋‹ˆ low grade ๊ฐ€ ์•„๋‹Œ ์ด์ƒ Epithelial dysplasia, HG ๋Š” ์•”๋“ฑ๋ก ๋Œ€์ƒ์œผ๋กœ ๋‹ต๋ณ€์ด ๋˜์–ด์žˆ์–ด์„œ ์žฌ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋‹ต๋ณ€1) High grade dysplasia(/2) ๋กœ ์ค„ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.2022๋…„ ๋‹ต๋ณ€ ๋‹น์‹œ, 'epithelial' ์ด ์ฝ”๋“œ์— ์˜ํ–ฅ์„ ๋ฏธ์น ์ง€์— ๋Œ€ํ•ด ๋ช…ํ™•ํ•˜์ง€ ์•Š์•„ ๋ณธ์› ์˜๋ฃŒ์ง„์—๊ฒŒ ํ™•์ธํ•˜๋ผ๋Š” ๋‹ต๋ณ€์„ ๋“œ๋ ธ์Šต๋‹ˆ๋‹ค. ํ˜„์žฌ๋Š” 'epithelial' ์œ ๋ฌด์™€ ์ƒ๊ด€์—†์ด 'High grade dysplasia' ๋ฅผ ์ง„๋‹จ๋ฐ›์•˜๊ธฐ์— '/2' ํ–‰ํƒœ์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.๋‹ต๋ณ€2) ๋ณ‘๋ฆฌ์˜(high grade dysplasia, /2)์™€ ์ฃผ์น˜์˜(benign, /0)์˜ ์˜๊ฒฌ ๋‹ค๋ฅธ ๊ฒฝ์šฐ๋กœ ๋ณธ์› ์˜๋ฃŒ์ง„์—๊ฒŒ ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.
.์งˆ๋ฌธ์žˆ์–ด ๊ธ€ ๋‚จ๊น๋‹ˆ๋‹ค.๊ตฌ๊ฐ•์•”์˜ ๊ฒฝ์šฐ HPV ๊ฐ€ ์–‘์„ฑ์ด๋ƒ ์Œ์„ฑ์ด๋ƒ์— ๋”ฐ๋ผ ํ˜•ํƒœํ•™ ์ฝ”๋“œ๊ฐ€ 8085,8086์œผ๋กœ ๋‚˜๋‰œ๋‹ค๊ณ  ์•Œ๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค.์—ฌ๊ธฐ์„œ, ๊ถ๊ธˆํ•œ ์ ์€ ๋ชจ๋“  ๊ตฌ๊ฐ•์•”์— ํ•œํ•˜์—ฌ HPV ์— ๋”ฐ๋ผ ํ˜•ํƒœํ•™ ์ฝ”๋“œ๊ฐ€ ๋ฐ”๋€Œ๋Š”๊ฒƒ์ธ์ง€, ์•„๋‹ˆ๋ฉด AJCC 8th ์ฐจ ์ƒ์„ธ๋ถ€์œ„ ๊ฒ€์ƒ‰ ์‹œ HPV ์–‘์„ฑ์ด๋ƒ ์Œ์„ฑ์ด๋ƒ๋ฅผ ์„ ํƒํ•  ์ˆ˜ ์žˆ๋Š” ์ฐฝ์ด ๋œจ๋Š” ์•”์ข…์— ํ•œํ•˜์—ฌ ๋ฐ”๋€Œ๋Š”๊ฒƒ์ธ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค. ๋ช…ํ™•ํ•˜๊ฒŒ ์–ด๋–ค ์›๋ฐœ์•”์— ํ•œํ•˜์—ฌ HPV ์–‘์„ฑ ์Œ์„ฑ ํ˜•ํƒœํ•™์ฝ”๋“œ๋ฅผ ์‚ฌ์šฉํ•˜๋Š” ๊ฒƒ์ธ์ง€ ์•Œ๋ ค์ฃผ์‹œ๋ฉด ๊ฐ์‚ฌํ•˜๊ฒ ์Šต๋‹ˆ๋‹ค. ๋˜ํ•œ, ๋ณ‘๋ฆฌ๊ฒ€์‚ฌ ์ƒ DIAGNOSIS: Oral cavity, tongue, left, punch biopsy: squamous cell carcinoma์ƒ๊ธฐ ๋‚ด์šฉ๋งŒ ํ™•์ธ๋œ ๊ฒฝ์šฐ HPV ์— ๋Œ€ํ•œ ์ •๋ณด๋ฅผ ๊ธฐ๋ก์ง€ ๋‚ด์—์„œ ์ฐพ์„์ˆ˜ ์žˆ๋‹ค๋ฉด 8085,8086 ์„ ์‚ฌ์šฉํ•ด๋„ ๋˜๋Š”๊ฒƒ์ธ์ง€, ์•„๋‹ˆ๋ฉด ๋ณ‘๋ฆฌ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ์ง€์— ๋ช…ํ™•ํ•˜๊ฒŒ squamous cell carcinoma, HPV(+) ๊ฐ€ ๊ธฐ์žฌ๋˜์–ด์•ผ ์‚ฌ์šฉ๊ฐ€๋Šฅํ•œ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.์ƒ๊ธฐ ์งˆ๋ฌธ์— ๋Œ€ํ•œ ๋ช…ํ™•ํ•œ ๊ธฐ์ค€ ๋ฐ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฌ๋ฉฐ, ํ•ญ์ƒ ์•”๋“ฑ๋ก ๋ฌธ์˜์— ๋„์›€์ฃผ์…”์„œ ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๊ตฌ๊ฐ•์•”์˜ HPV(+), (-) ๊ด€๋ จ ์ฝ”๋“œ๋Š” ์ฃผ๋Š” ๋ฐฉ๋ฒ•์€ 1) ์›๋ฐœ์ด C00-C14(๊ตฌ๊ฐ•) ์ด๋ฉด์„œ ๋ณ‘๋ฆฌ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ์ง€์— 'Squmaous cell carcinoma' ์ง„๋‹จ์ด ๋‚˜์˜ค๋ฉด.. 2) HPV ๊ฒ€์‚ฌ ์—ฌ๋ถ€๋ฅผ ํ™•์ธํ•œ๋‹ค. 3) HPV ๊ฒ€์‚ฌ ์•ˆํ•จ: M8070/3 HPV(+): M8085/3 HPV(-): 8086/3
์งˆ๋ฌธ๊ณผ ๋‹ต๋ณ€ <๋ฒˆํ˜ธ 2629๋ฒˆ M์ฝ”๋“œ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.>์˜ ๋‹ต๋ณ€์— ๋Œ€ํ•ด ์žฌ์งˆ๋ฌธ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.<์ฐธ๊ณ :๋ฒˆํ˜ธ 2629๋ฒˆ >์งˆ๋ฌธ)์ฑ„์ทจ๋ถ€์œ„: 1:L2 IDEM tumorDIAGNOSIS:Spine, L2, biopsy: Paragangliomaํ™˜์ž๋ถ„ ์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ Paraganglioma ๋‚˜์™”์œผ๋‚˜ ์ฃผ์น˜์˜ ๊ต์ˆ˜๋‹˜์ด ๋ณ‘๋ฆฌ๊ณผ ๊ต์ˆ˜๋‹˜๊ณผ ์ƒ์˜ ํ›„ ์–‘์„ฑ์œผ๋กœ ์†Œ๊ฒฌ ์ฃผ์…จ์Šต๋‹ˆ๋‹ค. ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ์™€ ์ฃผ์น˜์˜ ์ง„๋‹จ์ด ๋‹ค๋ฅผ ๊ฒฝ์šฐ ์ฃผ์น˜์˜ ์ง„๋‹จ์— ๋”ฐ๋ผ ๋“ฑ๋กํ•˜๋ฏ€๋กœ C720 M8680/0์œผ๋กœ ์ƒ๊ฐ๋ฉ๋‹ˆ๋‹ค.paraganglioma๋Š” ICD-O-3 1st ์—์„œ๋Š” /0, /1 ๋ชจ๋‘ ๊ฐ€๋Šฅํ–ˆ์ง€๋งŒICD-O-3 2nd ์—์„œ๋Š” M์ฝ”๋“œ ์ž์ฒด๊ฐ€ ์•…์„ฑ์œผ๋กœ ๋ณ€๊ฒฝ๋œ ๊ฒƒ์œผ๋กœ ์•Œ๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค.์ด๋Ÿด ๊ฒฝ์šฐ ์–ด๋–ป๊ฒŒ ์•”๋“ฑ๋ก ํ•ด์•ผํ•  ์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋‹ต๋ณ€)๋ณ‘๋ฆฌ๊ณผ ๊ต์ˆ˜๋‹˜ ํ™•์ธ ๊ฒฐ๊ณผ ์–‘์„ฑ(benign)์ด ๋งž๋‹ค๋ฉด ์›๋ฐœ๋ถ€์œ„ C75.5 M8680/0 ์œผ๋กœ ์•”๋“ฑ๋ก ํ•ฉ๋‹ˆ๋‹ค.๋˜ํ•œ [bigo]๋ž€์— ํ•ด๋‹น ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์™€ ๋ณ‘๋ฆฌ์˜์‚ฌ benignํ™•์ธํ–ˆ๋‹ค๋Š” ๋‚ด์šฉ์„ ๊ธฐ์žฌ๋ฐ”๋ž๋‹ˆ๋‹ค.ใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…กใ…ก"์ข…์–‘ํ•™ ๊ตญ์ œ์งˆ๋ณ‘๋ถ„๋ฅ˜ ์ฝ”๋“œ(ICD-O-3 2nd revision)์™€ ์ฝ”๋”ฉ ๊ฐ€์ด๋“œ๋ผ์ธ"์—์„œ 8680/0 Paraganglioma, benign ์ฝ”๋“œ๋Š” Delete- ์‚ญ์ œ๋œ ์ฝ”๋“œ ๋ฐ ์šฉ์–ด ์ธ ๊ฒƒ์œผ๋กœ ์•Œ๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ๋‹ค์‹œ ํ•œ๋ฒˆ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฌ๊ฒ ์Šต๋‹ˆ๋‹ค.๋˜ ๋น„๊ณ ๋ž€์— ๋‚ด์šฉ์„ ๊ธฐ์žฌ๋ฐ”๋ž€๋‹ค๊ณ  ํ•ด์ฃผ์…จ๋Š”๋ฐ, ํ˜น์‹œ 8680/3์œผ๋กœ ์•”๋“ฑ๋ก ํ›„ ์ €ํฌ๋ณ‘์› ์•”๋“ฑ๋ก ๋‹ด๋‹น์ž๋‹˜์ด ์ผ๋…„์˜ ์•”๋“ฑ๋ก ์ž๋ฃŒ๋ฅผ๋ณด๋‚ด๋Š” ์—‘์…€ํŒŒ์ผ์— ๋‚ด์šฉ์„ ์ ์–ด๋‹ฌ๋ž€ ๋ง์”€์ด์‹ค๊นŒ์š”?!๋ฐ”์˜์‹  ์™€์ค‘์— ๊ฐ์‚ฌ๋“œ๋ฆฝ๋‹ˆ๋‹ค^^
๋„ค, ๋งž์Šต๋‹ˆ๋‹ค.์•”๋“ฑ๋กํ•ญ๋ชฉ ์ค‘์— [bigo] ๋ผ๋Š” ๋ฉ”๋ชจ๋ฅผ ๊ธฐ์žฌํ•˜๋Š” ํ•ญ๋ชฉ์ด ์žˆ์Šต๋‹ˆ๋‹ค.์ด [bigo] ํ•ญ๋ชฉ์— ํ•ด๋‹น ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์™€ ๋ณ‘๋ฆฌ์˜์‚ฌ๊ฐ€ benign ์œผ๋กœ ์ง„๋‹จ์„ ๋‚ด๋ฆฐ ๊ทผ๊ฑฐ ๋‚ด์šฉ์„ ์ž‘์„ฑํ•ด์ฃผ์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
์ˆ˜๊ณ ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค. ์œ ๋ฐฉ์•” Morphology ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.[์ˆ˜์ˆ ํ›„ Bx ๊ฒฐ๊ณผ] 1) Breast, central, right, skin-sparing mastectomy : - DUCTAL CARCINOMA IN SITU, grade 2, with Size/Extent: 2.2 cm x 4.0 cm Dimension (1): maximum extent on one slice: 2.2 x 1.8 cm Dimension (2): involving 8 slices (4.0 cm, slice #6 to #13) Type: solid, cribriform, micropapillary type Necrosis: absent Microcalcifications in tumor: present Margins: negative Distance to superficial margin: < 0.1 cm deep margin: 0.2 cm superior margin: 6.2 cm inferior margin: 5.2 cm medial margin: 3.0 cm lateral margin: 7.0 cm TNM staging: pTis pN0 (see NOTE 1) cM0. - LOBULAR CARCINOMA IN SITU, grade 2 Type: classic type Size: 0.3 x 0.5 cm (slice #17) Necrosis: absent Microcalcification: absent Margins: negative. 2) Breast, subareolar, right, excision : - Moderate ductal hyperplasia, benign breast tissue. 3) Breast, nipple, right, excision : - DUCTAL CARCINOMA IN SITU, grade 2 with Margins: negative.์œ„์™€ ๊ฐ™์ด ์ˆ˜์ˆ  ํ›„ ์œ ๋ฐฉ Bx ๊ฒฐ๊ณผ๊ฐ€ DUCTAL CARCINOMA IN SITU(M8500/2),LOBULAR CARCINOMA IN SITU(M8520/2)๊ฐ€ ๋‚˜์™”์„ ๊ฒฝ์šฐ,๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์œผ๋กœ ๋ชฐํด๋กœ์ง€๋Š” ๋‘˜ ์ค‘ ์ข…์–‘์˜ ๋Œ€๋ถ€๋ถ„์„ ์ฐจ์ง€ํ•˜๋Š” M8500/2 ๋กœ ํ•˜๋‚˜๋งŒ ๋“ฑ๋กํ•˜๋ฉด ๋˜๋Š”์ง€, ์•„๋‹ˆ๋ฉด ์กฐํ•ฉ์ฝ”๋“œ๋กœ M8522/2(Intraductal carcinoma and lobular carcinoma in situ)๋กœ ์ฃผ๋Š”๊ฒŒ ๋งž๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์ธ ๊ฒฝ์šฐ, ๋†’์€ ์ฝ”๋“œ(M8520/2)๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
.์ดˆ์ง„์ผ์˜ ๊ธฐ์ค€์„ ์žฌํ™•์ธํ•˜๊ณ ์ž ํ•ฉ๋‹ˆ๋‹ค.ํƒ€๋ณ‘์›๊ธฐ๋ก ์ค‘ ํ™•์ธ๋˜๋Š” ๊ฐ€์žฅ ๋น ๋ฅธ ๋‚ ์งœ๋ฅผ ์ž…๋ ฅ์ด ๊ธฐ์ค€์ด๋ผ๊ณ  ํ•œ๋‹ค๋ฉด,๊ฒ€์‚ฌ๊ฒฐ๊ณผ์ง€์ธ ๊ฒฝ์šฐ์— ๊ฒ€์‚ฌ์ฒ˜๋ฐฉ์ผ, ๊ฒ€์‚ฌ์‹œํ–‰์ผ, ๊ฒฐ๊ณผ๋ณด๊ณ ์ผ ์ค‘์—์„œ๊ฒ€์‚ฌ์ฒ˜๋ฐฉ์ผ๋กœ ์ž…๋ ฅํ•˜๋Š” ๊ฒƒ์ด ๋งž๋Š”์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.์˜ˆ์‹œ)๊ฒ€์ฒด์ ‘์ˆ˜์ผ(์ฒ˜๋ฐฉ์ผ) 2023.11.27 19:07๊ฒ€์‚ฌ์‹œํ–‰์ผ 2023.11.28๊ฒฐ๊ณผ๋ณด๊ณ ์ผ 2023.11.29 10:59
๋„ค, ๋งž์Šต๋‹ˆ๋‹ค.๊ฐ™์€ ๊ธฐ๋ก์ง€๋‚ด์—์„œ ๊ฐ€์žฅ ๋น ๋ฅธ ๋‚ ์งœ๋ฅผ ๊ธฐ์ค€์œผ๋กœ ์ž…๋ ฅํ•ด์ฃผ์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
.M์ฝ”๋“œ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ์กฐ์ง๋ณ‘๋ฆฌ ๊ฒฐ๊ณผ[ DIAGNOSIS ]Skin, chest, shave biopsy; Seborrheic keratosis, consistent with MelanoacanthomaD22.5 Melanocytic naevi of trunkM8720/0 Pigmented naevus NOS (M8720/0)๋กœ ์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌ ํ•˜๋Š”๊ฒŒ ์ ํ•ฉํ• ์ง€, ๋‹ค๋ฅธ ์ฝ”๋“œ๋กœ ๋ถ€์—ฌ ํ•ด์•ผํ•˜๋Š”์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
์˜ฌ๋ ค์ฃผ์‹  ๋‚ด์šฉ์€ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.์งˆ๋ณ‘๋ถ„๋ฅ˜์ฝ”๋“œ๋Š” ๋Œ€ํ•œ๋ณด๊ฑด์˜๋ฃŒ์ •๋ณด๊ด€๋ฆฌ์‚ฌํ˜‘ํšŒ์— ๋ฌธ์˜ ๋ฐ”๋ž๋‹ˆ๋‹ค.
2011๋…„ renal cell ca๋กœ ์ค‘๊ตญ์—์„œ right nephrectomyํ›„ 2020๋…„ pancrease์— mass ๋ฐœ๊ฒฌ๋˜์–ด recurr๋กœ ์ƒ๊ฐํ•˜๊ณ  votrient 400mg ํˆฌ์•ฝ ์‹œ์ž‘ํ•˜์˜€๊ณ  ํ™˜์ž์˜ compliance๊ฐ€ ์•ˆ์ข‹์•„(์„ค์‚ฌ๋“ฑ ๋ถ€์ž‘์šฉ) 2023๋…„์— Inlyta 5mg q 12h๋กœ ํˆฌ์•ฝ์ค‘์ธ ํ™˜์ž์ž…๋‹ˆ๋‹ค๋ณต๋ถ€CT์ƒ pacrease mass๋Š” 2018๋…„๋ถ€ํ„ฐ ์žˆ์—ˆ๋˜ ๊ฒƒ์œผ๋กœ ๋ณด์ด๋ฉฐ ์ดํ›„ lung metz ์žˆ์–ด ์กฐ์ง๊ฒ€์‚ฌ(2023๋…„ 9์›”)์ƒ renal cell ca๋กœ ์ง„๋‹จ ๋ฐ›์•˜์Šต๋‹ˆ๋‹ค. 23๋…„ 4์›”๊นŒ์ง€ ๋ณต๋ถ€ CT์—์„œ pacrease์—์„œ ๋ณด์ด๋˜ mass๋Š” ์—†์–ด์กŒ๊ณ  23๋…„ 7์›”๊ณผ 11์›”์— ์‹œํ–‰ํ•œ chest CT์ƒ lung metz size๊ฐ€ ์ ์ฐจ ์ปค์ง€๊ณ  metz์†Œ๊ฒฌ์œผ๋กœ resection ๊ถŒ์œ ํ•œ ์ƒํƒœ์ž…๋‹ˆ๋‹ค.renal cell ca. -> ์•”๋“ฑ๋ก ๋Œ€์ƒ์ธ์ง€ ์•„๋‹Œ์ง€ ํ™•์ธ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.(1 or 2) 1. 2011๋…„ renal cell ca. ์— ๋Œ€ํ•œ ์›๋ฐœ์•” ์•”๋“ฑ๋ก์„ ํ•œ๋‹ค. 2. ํ์— ์ „์ด์•” or ์žฌ๋ฐœ์•” ์ด๋ฏ€๋กœ renal cell ca.๋Š” ๊ณผ๊ฑฐ๋ ฅ์œผ๋กœ ๋ณด๊ณ  ๋“ฑ๋กํ•˜์ง€์•Š๋Š”๋‹ค. (+์ด๊ฒฝ์šฐ ํ์•”์€ ์ „์ด์•”์ธ๊ฐ€์š”? ์žฌ๋ฐœ์•”์ธ๊ฐ€์š”?)
2011๋…„ ์ง„๋‹จ๋ฐ›์€ ๋‚ด์šฉ์œผ๋กœ renal cell carcinoma ์— ๋Œ€ํ•œ ์•”๋“ฑ๋ก์„ ํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
ํƒ€๋ณ‘์›์—์„œ 6๋…„์ „๋ถ€ํ„ฐ Primary myelofibrosis๋กœ Jakavi๋ฅผ ์‹œ์ž‘ํ–ˆ๋‹ค๋Š” ์ •๋ณด๊ฐ€ ์žˆ๊ณ  ์ €ํฌ ๋ณ‘์›์—๋Š” F/U ๋ฐ ์•ฝ์„ ์ฒ˜๋ฐฉ๋ฐ›์œผ๋ ค ์™ธ๋ž˜ ๋‚ด์›ํ•˜์˜€์Šต๋‹ˆ๋‹ค. ๊ณผ๊ฑฐ์ •๋ณด๊ฐ€ ์—†์–ดC42.1, M9961/3, ์ง„๋‹จ๋ฐฉ๋ฒ•: 1, ์น˜๋ฃŒ๋ฐฉ๋ฒ• : ํ•ญ์•”์œผ๋กœ ์ฒดํฌํ•˜๋ฉด ๋˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
C42.1, M9800/3(Leukemia, NOS), ์ง„๋‹จ๋ฐฉ๋ฒ•: 1, ์น˜๋ฃŒ๋ฐฉ๋ฒ•: ํ•ญ์•”์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
lung caํ™˜์ž๋กœ ์ˆ˜์ˆ  ์กฐ์ง๊ฒ€์‚ฌ์—์„œ Lung, left lobe, decortication;- ADENOCARCINOMA, solid predominant (solid 80% + papillary 20%) with SARCOMATOID differentiation, see note. 1) Histologic grade: G3 (poorly differentiated) 2) Mitotic count: high mitotic count (>5/10HPF).......๊ณผ ๊ฐ™์€ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค.M์ฝ”๋“œ๋ฅผ solid predominant (solid 80% + papillary 20%)์„ ์ ์šฉํ•˜์—ฌ M8230/3์œผ๋กœ ๋ถ„๋ฅ˜ํ•˜๋ฉด ๋˜๋Š”์ง€์š”?
๋„ค, M8230/3(Soild adenocarcinoma)์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
[DIAGNOSIS] Uterus, total laparoscopic hysterectomy: ENDOMETRIOID ADENOCARCINOMA, FIGO GRADE 1/3, ABOUT 2.5X2.0 CM, ENDOMETRIUM with 1) squamous differentiation:PRESENT 2) depth of invasion: limited to endometrium 3) low uterine segment involvement: absent 4) cervical stromal connective tissue invasion: absent 5) serosal and/ or adnexa involvement: absent 6) lymphovascular invasion: not identified 7) perineural invasion: not identified 8) cervical resection margin involvement: absent 9) other findings: adenomyosis. ENDOMETRIOID ADENOCARCINOMA with squamous differentiation M8570/3 ์œผ๋กœ ๋ถ€์—ฌํ•˜๋ฉด ๋˜๋Š”์ง€ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. (ํ•ด๋‹น๋ณ‘์› ๋ณ‘๋ฆฌ์—์„œ๋Š” ์ •ํ™•ํ•œ ๋‹ต๋ณ€์„ ๋ฐ›์ง€ ๋ชปํ–ˆ์Šต๋‹ˆ๋‹ค)
M8380/3(Endometrioid adenocarcinoma)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
Skin, nose, excision: Basal cell carcinoma Skin, lower lip, excision: Basal cell carcinoma ์ „์ด, ์žฌ๋ฐœ์—†์ด ๋™์ผ์‹œ์ ์— C44.0, C44.3 ํ•จ๊ป˜ ์ง„๋‹จ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.๊ฐ๊ฐ ๋ถ€์œ„์— ๋™์ผ ์กฐ์งํ•™์  ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”๋Š”๋ฐ ์•”๋“ฑ๋ก์„ ๊ฐ๊ฐ 2๋ฒˆ ํ•ด์•ผ ํ•˜๋‚˜์š”?ํ™•์ธ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
C443(Skin of face)๋กœ ํ•œ๋ฒˆ๋งŒ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ์ƒ Kindey, left, US guided biopsy : Scattered atypical epithelial clusters with marked necrosis, suspicious of SMARCB1 deficient renal medullary carcinoma. ์œผ๋กœ ๋‚˜์™”์Šต๋‹ˆ๋‹ค. SMARCB1 deficient renal medullary carcinoma->M ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M8510/3(Medullary carcinoma,NOS)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.[WHO Classification of Tumours of the Urinary and Male Genital System 2022, p.84 ์ฐธ๊ณ ]
!๋‚œ์†Œ์˜ ๊ฒฝ๊ณ„ํ˜• ์ข…์–‘์˜ ์กฐ์งํ•™์ฝ”๋“œ์— ๋Œ€ํ•ด ์งˆ๋ฌธ๋“œ๋ฆฝ๋‹ˆ๋‹ค.์กฐ์ง๊ฒ€์‚ฌ์ƒ Mucinous borderline tumor with focal microinvasion ์ธ ๊ฒฝ์šฐ,๋‹ค๋ฅธ ์งˆ์˜๊ธ€์—์„œ M8472/3๋กœ ๋“ฑ๋กํ•˜๋ผ๋Š” ๋‹ต๋ณ€์„ ํ™•์ธํ•˜์˜€์Šต๋‹ˆ๋‹ค.ํ•ด๋‹น ์ฝ”๋“œ๋Š” ํ˜„์žฌ ์ƒ์„ฑ๋˜์–ด์žˆ์ง€์•Š์€๋ฐ M8472/3์ด๋‚˜ M8442/3์„ ์ž์ฒด์ ์œผ๋กœ ์ฝ”๋“œ๋ฅผ ์ƒ์„ฑํ•ด์„œ ๋“ฑ๋กํ•˜๋ฉด ๋ ๊นŒ์š”? ๊ทธ๋ ‡๊ฒŒํ•œ๋‹ค๋ฉด ๋งคํฌ๋กœ์— ์˜ค๋ฅ˜๋กœ ๋œฐ๊ฑฐ๊ฐ™์€๋ฐ ์–ด๋–ป๊ฒŒ ํ•ด์•ผํ•˜๋Š”์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค!โ—Ž ๋ณ‘ ๋ฆฌ ์ง„ ๋‹จ1. Adnexa, right, salpingo-oophorectomy (S2023-17786); 1) Mucinous borderline tumor with focal microinvasion (3), ovary โ—Ž ๋ณ‘ ๋ฆฌ ์ง„ ๋‹จAdnexa, right, pelviscopic salpingo-oophorectomy;1) Serous borderline tumor (A1,B3-B7) with focal microinvasion (B7), ovary, and (1) non-invasive implant, periovarian soft tissue (2) ovarian surface involved
๊ฐ๊ฐ M8472/3, M8442/3 ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.(๋น„๊ณ ๋ž€์— bx ๊ฒฐ๊ณผ๋ฅผ ๊ธฐ์žฌ๋ฐ”๋ž๋‹ˆ๋‹ค.)
์ด๋ฒˆ 12์›”๋‹ฌ ๋‚ด์›์‹œ ํ™˜์ž๊ฐ€ Anus intraepithelial neoplasia , high grade ์ง„๋‹จ์„ ๋ฐ›์•˜์Šต๋‹ˆ๋‹ค.(์ด์ „ 11์›”๋‹ฌ ๋‚ด์›์‹œ๋Š” ํ•ญ๋ฌธ์˜ ์–‘์„ฑ์‹ ์ƒ๋ฌผ ์ง„๋‹จ์„ ๋ฐ›๊ณ  ํ‡ด์›ํ•˜์˜€์Šต๋‹ˆ๋‹ค.) ์•”๋“ฑ๋ก์ง€์นจ์„œ์— ๋”ฐ๋ฅด๋ฉด, high grade๋ฅผ /2๋กœ ์ธ์ •ํ•˜๋Š” ์›๋ฐœ๋ถ€์œ„์— ํ•ญ๋ฌธ(anus) ๋Š” ํฌํ•จ๋˜์–ด ์žˆ์ง€ ์•Š์€๊ฒƒ์œผ๋กœ ํ™•์ธ๋ฉ๋‹ˆ๋‹ค. ๊ทธ๋Ÿฐ๋ฐ ์˜์‚ฌ๊ณผ ์กฐ์ง๊ฒ€์‚ฌ์‹ค์—์„œ๋Š” ์ œ์ž๋ฆฌ์•”(/2)์œผ๋กœ ๋ณด์‹ ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค.์ง€์นจ๊ณผ ์ž„์ƒ์†Œ๊ฒฌ์ด ์ƒ์ดํ•˜์—ฌ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก ์ง€์นจ ์ƒ ๊ทธ ์™ธ์˜ ๋ถ€์œ„๋Š” ์ฃผ์น˜์˜์™€ ์ƒ์˜ ํ›„ ๊ฒฐ์ •ํ•ฉ๋‹ˆ๋‹ค.๋ณ‘๋ฆฌ์˜ ์†Œ๊ฒฌ๊ณผ ์ž„์ƒ์†Œ๊ฒฌ์ƒ ์ œ์ž๋ฆฌ์•”์œผ๋กœ ์ง„๋‹จ๋˜์—ˆ๊ธฐ ๋•Œ๋ฌธ์—, M8077/2(Anal intraepithelial neoplasia, grade lll)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
Small bowel, segmental resection;Desmoid-type fibromatosis, intra-abdominal(mesenteric)์œ„์™€ ๊ฐ™์€ ์กฐ์ง๋ณ‘๋ฆฌ ๋‚˜์˜จ ํ™˜์ž๋กœICD-O-3 Morphology search ์‹œ M8821/1 Desmoid type fibromatosis ๋ฏธ์ƒ[์ž„์ƒ์˜ ์ง„๋‹จ ๋ฐ ์˜๊ฒฌ]** C49.4 Malignant neoplasm of connective and soft tissue of abdomen ์ง„๋‹จ ํ•˜ malignant tumor ์ค€ํ•ด์„œ ์น˜๋ฃŒ s/p RTx on abdomen (5000cGy/25fr) s/p 1L vinblastin & MTX Chemoport ์‚ฝ์ž… ์‹œํ–‰* C49.4 ์‚ฐ์ •ํŠน๋ก€๋“ฑ๋ก์‹ ์ฒญ ์œ„ ๊ฒฝ์šฐ, M8821/3 ์ƒ์„ฑํ•˜์—ฌ ๋“ฑ๋ก์„ ํ•ด๋„ ๋˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
ํ–‰ํƒœ์ฝ”๋“œ๋ฅผ ์•…์„ฑ์œผ๋กœ ๋ณ€๊ฒฝํ•  ์ˆ˜ ์žˆ๋Š” ๊ฒฝ์šฐ๋Š” ๋ณ‘๋ฆฌ์˜๊ฐ€ ์•…์„ฑ์•”์œผ๋กœ ํŒ๋‹จํ•˜์˜€์„ ๊ฒฝ์šฐ์— ํ•œํ•ฉ๋‹ˆ๋‹ค. (์•”๋“ฑ๋ก ์ง€์นจ ๊ทœ์น™ F, p.41)์•…์„ฑ์ข…์–‘์— ์ค€ํ•˜์—ฌ ์น˜๋ฃŒ๋ฅผ ์‹œํ–‰ํ•œ ๊ฒฝ์šฐ๋ผ๋„, ๋ณธ ์ง€์นจ์„ ์ ์šฉํ•  ์ˆ˜ ์—†๊ธฐ ๋•Œ๋ฌธ์— ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
์š”์ฆ˜์€ ๊ฑด๊ฐ•๊ฒ€์ง„์œผ๋กœ Brain CT ๋˜๋Š” MRI๋ฅผ ๋งŽ์ด ๊ฒ€์‚ฌํ•จ์— ๋”ฐ๋ผ ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์—์„œ DDx ๋˜๋Š” R/O์œผ๋กœ Meningioma ๋˜๋Š” Schwannoma ๋“ฑ ์–‘์„ฑ์ข…์–‘์ด ๋ฐœ๊ฒฌ๋˜์–ด ์‹ ๊ฒฝ์™ธ๊ณผ๋ฅผ ์ง„๋ฃŒ๋ฐ›๊ฒŒ๋˜๋Š” ๊ฒฝ์šฐ๊ฐ€ ์ข…์ข… ์žˆ์Šต๋‹ˆ๋‹ค. ํ™•์ง„๋œ ๊ฒฝ์šฐ๋„ ์žˆ๊ตฌ์š”. ๊ทธ๋Ÿฐ๋ฐ ์ด๋Ÿฐ ๊ฒฝ์šฐ ์‚ฌ์ด์ฆˆ๊ฐ€ ์•„์ฃผ ๋ฏธ๋ฏธํ•˜๊ฑฐ๋‚˜ ํฌ๊ฒŒ ๋ฌธ์ œ๋˜์ง€ ์•Š๋Š” ๊ฒฝ์šฐ์—๋Š” 1๋…„๋งˆ๋‹ค F/U ํ•˜๊ธฐ๋งŒ ํ•˜๋Š” ํ™˜์ž๋“ค์ด ์žˆ์Šต๋‹ˆ๋‹ค. ์ž„์ƒ์˜์‚ฌ๊ฐ€ ํ™•์ง„ํ•œ ๊ฒฝ์šฐ์—๋Š” ์ด๋ ‡๊ฒŒ F/U๋งŒ ํ•˜๋Š” ํ™˜์ž๋“ค๋„ ๋ชจ๋‘ ์•”๋“ฑ๋ก์„ ํ•ด์•ผํ•˜๋‚˜์š”? ์ด๋Ÿฐ ๊ฒฝ์šฐ์—๋Š” ์ž„์ƒ์˜์‚ฌ๋“ค์ด ํ™˜์ž๋ฅผ ์‚ฐ์ •ํ•ด๋‹น ํ™˜์ž๋กœ ๋“ฑ๋กํ•˜์ง€๋„ ์•Š์Šต๋‹ˆ๋‹ค.์ง€๊ธˆ๊นŒ์ง€ ์ž„์ƒ์˜์‚ฌ๊ฐ€ ํ™•์ง„ํ•œ ๊ฒฝ์šฐ์—๋Š” ์•”๋“ฑ๋ก์„ ํ•ด์™”๋Š”๋ฐ ์ ์  ๊ฒ€์ง„์œผ๋กœ ์ธํ•ด ์ด๋Ÿฐ ํ™˜์ž๋“ค์ด ๋งŽ์•„์ง€๊ณ  ์žˆ์–ด์„œ ๋ช…ํ™•ํžˆ ํ•˜๊ณ ์ž ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
ํ™•์ง„๋œ ๊ฒ€์‚ฌ๊ฒฐ๊ณผ๋ฅผ ํ† ๋Œ€๋กœ ์•”๋“ฑ๋ก ํ•ฉ๋‹ˆ๋‹ค.
ํ™˜์ž๋ถ„ ํƒ€๋ณ‘์›์—์„œ ๊ฐ€์ ธ์˜ค์‹  ์™ธ๋ถ€ ์Šฌ๋ผ์ด๋“œ ํŒ๋…๊ฒฐ๊ณผBreast, left, 2 o'clock, needle biopsy: . INVASIVE DUCTAL CARCINOMA, nuclear grade 3/3, histologic grade 3/3. . Microcalcification in stroma.2. Breast, left, 12 o'clock, needle biopsy: . INVASIVE DUCTAL CARCINOMA, nuclear grade 3/3, histologic grade 3/3. . No microcalcification.3. Soft tissue, axilla, left, needle biopsy: . INVASIVE DUCTAL CARCINOMA, nuclear grade 3/3, histologic grade 3/3. (see note) . No microcalcification.์†Œ๊ฒฌ ๋ณด์ด์‹  ๋ถ„์œผ๋กœ, ๋ณธ์›์—์„œ ํ•ญ์•”์น˜๋ฃŒ ์‹œํ–‰ํ›„ ์ˆ˜์ˆ ํ•˜์—ฌ ๋‚˜์˜จ ์กฐ์ง๊ฒ€์‚ฌ์—์„œBreast, left, upper outer and upper center, partial mastectomy with sentinel lymph node biopsy : . Status post neoadjuvant chemotherapy (RT2023-468 : nuclear grade, 3 / 3; histologic grade, 3 / 3; overall cancer cellularity, 50 %). . Metaplastic carcinoma, squamous cell type, residual ;1) tumor size: 0.8x0.5x0.5 cm (DCIS extent, up to 3 cm largest tumor bed size: 2x1.9 cm) (overall cancer cellularity: 20 %) (ypT1) 2) nuclear grade: high with central necrosis 3) Bloom-Richardson grade: 3 / 3 4) lymphovascular invasion: absent 5) intraductal component: 30 % / EIC ( + ), flat and cribriform type Van Nuys classification group: 3 / 3 6) microcalcification in benign duct, stroma, and tumor 7) negative but very close medial resection margin (see IT2023-16337) 8) negative other resection margins (superior, 0.3 cm; inferior, 0.3 cm; lateral, 1.3 cm; deep, 1.9 cm; superficial, 0.5 cm) 9) no metastasis in 8 regional lymph nodes (ypN0) (0/8 : Left sentinel lymph node #1 to #6 for frozen "IT2023-16355", 0/6; Left non-sentinel lymph node #1 to #3 for frozen "IT2023-16355", 0/2)๋ณ‘๋ฆฌ๊ฒ€์‚ฌ ๋‚˜์˜ค์‹  ํ™˜์ž๋ถ„์ด์‹ญ๋‹ˆ๋‹ค.์ฒ˜์Œ ์•”๋“ฑ๋ก์‹œ M8500/3์œผ๋กœ ์•”๋“ฑ๋กํ•˜์˜€๋Š”๋ฐ, ์ˆ˜์ˆ ํ›„ Metaplastic carcinoma ๋‚˜์™€ M8575/3์œผ๋กœ M์ฝ”๋“œ ์ˆ˜์ •ํ•˜๋Š” ๊ฒƒ์ด ๋งž๋Š”์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
ํ•ญ์•”์น˜๋ฃŒ ์ „ ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ์ธ, M8500/3 (Invasive ductal carcinoma)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
. ์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์€ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค.Urinary bladder, anterior wall(#1), transurethral resection; Invasive urothelial carcinoma with extensive squamous differentiation, high grade, with involvement of subepithelial connective tissueM์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
M8120/3 (urothelial carcinoma)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค
์•„๋ž˜์™€ ๊ฐ™์ด ํ™•์ธ๋˜๋Š” ๊ฒฝ์šฐ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.subtype์„ ๋ณด๋ฉด non-mucinous adenocarcinoma์ธ ๊ฒƒ์„ ํ™•์ธํ•  ์ˆ˜ ์žˆ์œผ๋ฏ€๋กœ,> ๊ทธ ์ค‘ ๋งŽ์€ ๋น„์ค‘์„ ์ฐจ์ง€ํ•˜๋Š” lepidic์„ ๋‚˜ํƒ€๋‚ด๋Š” M8250/3 Lepidic adenocarcinoma ์œผ๋กœ ๋“ฑ๋กํ• ์ง€,> Minimally invasive๋ฅผ ๋‚˜ํƒ€๋‚ด๋Š” M8256/3 Minimally invasive adenocarcinoma, non-mucinous ์œผ๋กœ ๋“ฑ๋กํ•ด์•ผํ• ์ง€๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.Lung, right, upper, wedge resection; Minimally invasive adenocarcinoma - Preoperative treatment : None - Tumor size (entire): 2.0x1.3x0.9cm - Size of invasive component : 0.4cm - Histologic patterns: lepidic 90%, acinar 10% - Histologic grade: IASLC grade 1 - Bronchial involvement: Not identified - Visceral pleural invasion: Not identified (PL0) - Necrosis: Not identified - Lymphovascular invasion: Not identified - Perineural invasion: Not identified - Spread through air spaces (STAS): Not identified - Resection margin: Free from tumor (safety margin; parenchymal : 0.7cm) - Regional lymph nodes : No metastasis in 7 lymph nodes (0/7) LN2(0/1), LN4(0/1), LN10(0/5) - Associated finding: None - Non-neoplastic lung: Emphysematous change; subpleural fibroelastosis, mild - Pathologic staging: pT1miN0 (AJCC 8th ed.)
๋งŽ์€ ๋น„์ค‘์„ ์ฐจ์ง€ํ•˜๋Š” lepidic์„ ๋‚˜ํƒ€๋‚ด๋Š” M8250/3 Lepidic adenocarcinoma๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์„ ์ƒ๋‹˜ํ‡ด์›๋ถ„์„ ์—…๋ฌด ์ค‘ melanoma์— ๋Œ€ํ•ด seer ์งˆ๋ฌธ ๋ฐœ์ƒํ•˜์—ฌ ์งˆ๋ฌธ ๋‚จ๊น๋‹ˆ๋‹ค.DIAGNOSIS: Back, left, wide excision: Malignant round cell tumor, consistent with malignant melanoma, metastatic 1) Size of tumor: 2.4x1.6x1.2cm . . . 7) Extension: confinement to soft tissueํ•ด๋‹น ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋ฅผ ํ† ๋Œ€๋กœ seer ๋ฅผ ๋ถ€์—ฌํ•œ๋‹ค๋ฉด seer 1๊ณผ 2 ์ค‘ ์–ด๋Š๊ฒƒ์„ ๋ถ€์—ฌํ•ด์•ผํ•˜๋Š”์ง€ ์•Œ๊ณ ์‹ถ์Šต๋‹ˆ๋‹ค.ํ™•์ธ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
์›๋ฐœ๋ถ€์œ„ ํ™•์ธ์ด ์šฐ์„ ๋˜์–ด์•ผ ํ•ฉ๋‹ˆ๋‹ค. ์˜ฌ๋ ค์ฃผ์‹  ๋‚ด์šฉ์œผ๋กœ๋Š” ๋‹ต๋ณ€์ด ๋ถˆ๊ฐ€๋Šฅ ํ•ฉ๋‹ˆ๋‹ค.
์•„๋ž˜์™€ ๊ฐ™์ด ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.1. Pituitary incidentaloma ๋„ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ธ์ง€2. ๋งŒ์•ฝ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ๋งž๋‹ค๋ฉด, ์›๋ฐœ์žฅ๊ธฐ : C751 ์กฐ์งํ•™์ ์ง„๋‹จ๋ช… : 80001 ์œผ๋กœ ์•”๋“ฑ๋ก์„ ํ•˜๋ฉด ๋ ์ง€๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
incidentaloma๋Š” ์ •์˜๋˜์ง€ ์•Š์€ ์šฐ์—ฐํžˆ ๋ฐœ๊ฒฌ๋œ ๋ณ‘๋ณ€์„ ์˜๋ฏธํ•ฉ๋‹ˆ๋‹ค. ์ถ”๊ฐ€์ ์œผ๋กœ ๋‹ค๋ฅธ ์ง„๋‹จ์ด ์—†๋‹ค๋ฉด ์•”๋“ฑ๋ก ๋Œ€์ƒ ์—ฌ๋ถ€๋ฅผ ํŒ๋‹จํ•  ์ˆ˜ ์—†์Šต๋‹ˆ๋‹ค.
1. Urinary bladder, "bladder tumor", TUR-B: Invasive urothelial carcinoma, high-grade (A), with 1) depth of invasion: lamina propria 2) presence of proper muscle component: absent์ด ๊ฒฝ์šฐ M์ฝ”๋“œ๋Š” M8120/2(urothelial carcinoma in situ) ๋˜๋Š” M8120/3(urothelial carcinoma, NOS) ์ค‘ ์–ด๋–ค๊ฑธ ๋ถ€์—ฌํ•ด์•ผํ•˜๋‚˜์š”?
M8120/3(urothelial carcinoma, NOS)์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
**๊ธฐ์กด ๋‹ต๋ณ€**SEER์ฝ”๋“œ๋Š” '9๋ฒˆ(unknown)'์œผ๋กœ ์ฃผ์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.์ดˆ์ง„ 4๊ฐœ์›” "์ด๋‚ด๋งŒ" ์ ์šฉ ํ•ญ๋ชฉ: ์น˜๋ฃŒ, seer, ์ „์ด๋ถ€์œ„, stage์ด์™ธ ์ถ”๊ฐ€๋กœ ์ •๋ฆฌํ•ด์ฃผ์‹  ๋‚ด์šฉ ๋ชจ๋‘ ๋งž์Šต๋‹ˆ๋‹ค.*****-- ์ดˆ์ง„ 4๊ฐœ์›” ์ด๋‚ด์—๋งŒ ์ˆ˜์ •๋˜์–ด์•ผ ํ•˜๋Š” SEER ์— ๋Œ€ํ•ด, ๊ธฐ์กด IN SITU - UNKNOWN ์œผ๋กœ ์ˆ˜์ •ํ•˜๋ผ๊ณ  ๋‹ต๋ณ€ ์ฃผ์‹  ๋‚ด์šฉ์ด ์ดํ•ด๊ฐ€๊ฐ€์ง€ ์•Š์•„ ์žฌ์งˆ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.4๊ฐœ์›” ์ด๋‚ด์˜ ๊ฒฐ๊ณผ๋งŒ ์ ์šฉํ•œ๋‹ค๋ฉด IN SITU๋กœ ์œ ์ง€ํ•ด์•ผํ•˜๋Š” ๊ฒƒ์ด ์•„๋‹Œ์ง€์š”?
์œ ์„ ๋‹ต๋ณ€ ์™„๋ฃŒํ•˜์˜€์Šต๋‹ˆ๋‹ค.
๋ณต๋ง‰ ์ˆ˜์ˆ ํ•œ ํ™˜์ž๋กœ ์กฐ์ง๋ณ‘๋ฆฌ๊ฐ€ ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.Peritoneum, robot assisted excision; SchwannomaSchwannoma M9560/0 ์œผ๋กœ ์–‘์„ฑ์œผ๋กœ ๋ถ„๋ฅ˜ํ•˜์—ฌ D36.1 ๋ถ€์—ฌํ•˜์˜€๋Š”๋ฐ,์ž„์ƒ๊ต์ˆ˜๋‹˜์€ D48.3 ํ›„๋ณต๋ง‰์˜ ๋ฏธ์ƒ ์‹ ์ƒ๋ฌผ๋กœ ์ฝ”๋“œ๋กœ ์ง„๋‹จ์„ ๋‚ด๋ฆฌ์…จ์Šต๋‹ˆ๋‹ค. ์‹ ๊ฒฝ์ดˆ์ข…์€ ์–‘์„ฑ์œผ๋กœ ์•Œ๊ณ  ์žˆ๋Š”๋ฐ, ์ž„์ƒ์˜์˜ ํŒ๋‹จ์œผ๋กœ ๋ฏธ์ƒ ์‹ ์ƒ๋ฌผ๋กœ ํŒ๋‹จํ•ด๋„ ๋˜๋Š”๊ฑธ๊นŒ์š”?
ํ›„๋ณต๋ง‰์— ์ƒ๊ธด ๋ฏธ์ƒ ๋˜๋Š” ์–‘์„ฑ์‹ ์ƒ๋ฌผ์€ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.์งˆ๋ณ‘๋ถ„๋ฅ˜์ฝ”๋“œ๋Š” ๋Œ€ํ•œ๋ณด๊ฑด์˜๋ฃŒ์ •๋ณด๊ด€๋ฆฌ์‚ฌํ˜‘ํšŒ์— ๋ฌธ์˜ ๋ฐ”๋ž๋‹ˆ๋‹ค.
. lymphoma ๊ด€๋ จ ์•”๋“ฑ๋ก ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์™€ PET-CT ์•„๋ž˜์™€ ๊ฐ™์ด ๋‚˜์˜จ ํ™˜์ž์ž…๋‹ˆ๋‹ค. # Duodenum, ampulla, endoscopic biopsy (S2023-47856) High grade B cell lymphoma, most likely diffuse large B cell lymphoma. Note: 1) Results of immunohistochemistry CD20, CD10, Bcl-6: Positive CD3, Bcl-2, MUM1, Cytokeratin: Negative Ki-67 proliferation index: 90% 2) Result of EBER in situ hybridization Negative # Lung, right lower lobe, biopsy: Non-Hodgkin's lymphoma (see result of S2023-47856) Note: CD56(-), CK(-), TTF-1(-), Synaptophysin(-), P40(-), Chromogranin(-), LCA(+) # Torso (skull base-upper thigh) PET/CT Duodenal cancer without metastasis r/o primary lung cancer in RLL - DDx. inflammatory change Multiple inflammatory lesions in both lungs r/o inflammatory change in the right thigh ํ‡ด์› ํ›„ ์™ธ๋ž˜๊ธฐ๋ก ์ƒ NHL (DLBCL-NOS, lung/duodenum) ์ž‘์„ฑ ํ•˜์…จ๋Š”๋ฐ, ์•”๋“ฑ๋ก ์›๋ฐœ์ฝ”๋“œ ์–ด๋–ป๊ฒŒ ๋“ฑ๋กํ•˜์—ฌ์•ผ ํ• ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์ƒ ๋ฆผํ”„์ ˆ ์นจ๋ฒ”์ด ์—†๋Š” ๊ฒƒ์œผ๋กœ ํ™•์ธ๋œ ๊ฒฝ์šฐ C809๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.[์•”๋“ฑ๋ก ์ง€์นจ ๋ณ€๊ฒฝ ๋ฐ ์ฃผ์š”์‚ฌํ•ญ ๊ณต์ง€(2018) p.3_๋ฆผํ”„์ข… ์›๋ฐœ๋ถ€์œ„ ์ฝ”๋”ฉ ]์ฐธ๊ณ 
ํ™˜์ž ๋ถ„ BM Bx. ์ƒ ๋‹ค์Œ๊ณผ ๊ฐ™์ด ๋ณด๊ณ  ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.Hematologic diagnosis:S/O Lymphoplasmacytic lymphomaStage w/u PET-CT ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.PET-CT:Conclusion) 1. Diffuse FDG uptake in the whole spines, sternum, bilateral ribs, humerus, femurs, pelvic bones and scapula DDx.) #1. r/o reactive marrow hyperplasia #2. r/o multiple myeloma.์ฃผ์น˜์˜ ์ž„์ƒ์ง„๋‹จ Waldenstrom macroglobulinemia ๋กœ ๋‚ด๋ ธ๊ณ ,์ž„์ƒ์ •๋ณด ์ƒ, Lymphoplasmacytic lymphoma์™€ Waldenstrom macroglobulinemia ๋Š”๋™์ผํ•œ ์•”(๋™์˜์–ด)๋กœ ๋ณธ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค.ICD-O-3 ์—์„  Lymphoplasmacytic lymphoma ๋Š” M9671/3Waldenstrom macroglobulinemia ๋Š” C42.0 M9761/3 ์œผ๋กœ์›๋ฐœ๋ถ€์œ„์™€ Morphology ์ฝ”๋“œ๊ฐ€ ์ƒ์ดํ•œ๋ฐ,์–ด๋–ค๊ฑธ๋กœ ๋“ฑ๋กํ•˜๋Š”๊ฒŒ ๋งž์„์ง€์š”..?๋ฐ”์˜์‹œ๊ฒ ์ง€๋งŒ, ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
์ฃผ์น˜์˜ ์ง„๋‹จ์— ๋”ฐ๋ผ ์ง„๋‹จ๋ฐฉ๋ฒ•์€ 1(์ž„์ƒ์ง„๋‹จ), Waldenstrom macroglobulinemia (M9671/3)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.[์•”๋“ฑ๋ก ์ง€์นจ์„œ p. 40_ํ‘œ13. ๋น„ํ˜„๋ฏธ๊ฒฝ์  ๋ฐฉ๋ฒ•์œผ๋กœ ์ง„๋‹จ์‹œ ์ธ์ •๋˜๋Š” ์กฐ์งํ•™์  ์†Œ๊ฒฌ]์ฐธ๊ณ 
, ๋ณ‘๋ฆฌ ๊ฒฐ๊ณผ์— ๋”ฐ๋ฅธ Morphology ์ฝ”๋“œ ๋ฐ ์•”๋“ฑ๋ก ์งˆ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.------------------------------------------------------------------------[๋ณ‘๋ฆฌ ๊ฒฐ๊ณผ]Supraglottis, "epiglottis laryngeal surface"(frozen No.1 and No.1), laryngeal microsurgery; Mixed neuroendocrine tumor, grade 1, and squamous cell carcinoma, well differentiated (SEE NOTE) with 1. mitotic count: <1/10HPF (in neuroendocrine tumor area) 2. lymphovascular invasion: not identifiedNote) ์ด์ „ ๊ฒฝ๋ถ€ ๋ฆผํ”„์ ˆ(Lt.level IIa) ์Šฌ๋ผ์ด๋“œ(S23-24897)์„ ์žฌ๊ฒ€ํ† ํ•˜๊ณ  ๋ฉด์—ญ ์—ผ์ƒ‰์„ ์ถ”๊ฐ€ํ•˜์˜€์Šต๋‹ˆ๋‹ค. ๊ฒฝ๋ถ€ ๋ฆผํ”„์ ˆ ์กฐ์ง์—์„œ๋Š” ์‹ ๊ฒฝ๋‚ด๋ถ„๋น„ ํ‘œ์ง€์ž๊ฐ€ ์Œ์„ฑ์ธ ํŽธํ‰์ƒํ”ผ์•”์ด ๊ด€์ฐฐ๋˜๋ฉฐ, supraglottis์—์„œ ๋ณด์ด๋Š” ํŽธํ‰์ƒํ”ผ์•”์— ๋น„ํ•ด ํ›จ์”ฌ ๋ถ„ํ™”๊ฐ€ ์ข‹์ง€ ์•Š์Šต๋‹ˆ๋‹ค. --------------------------------------------------------------------------์กฐ์ง ๋ณ‘๋ฆฌ ๊ฒฐ๊ณผ ์œ„์™€ ๊ฐ™์ด ํŒ๋…๋˜์—ˆ๋Š”๋ฐ, M8240/3 Neuroendocrine tumor NOS => (other specific carcinomas) M8070/3 Squamous cell carcinoma NOS => (squamous and transitional cell carcinoma)์œ„์™€ ๊ฐ™์ด ๊ฐ๊ฐ Morphology ์ฝ”๋“œ๋ฅผ ์ฃผ์–ด์•ผ ํ•  ์ง€, ์•„๋‹ˆ๋ฉด ๋ณ‘ํ•ฉ๋œ ์ฝ”๋“œ๊ฐ€ ๋”ฐ๋กœ ์žˆ์„์ง€ ์งˆ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ๊ฐ ๋ถ€์—ฌํ•˜๋Š” ๊ฒฝ์šฐ, ๋‘ ์กฐ์งํ•™์  ์ฝ”๋“œ๊ฐ€ ์„œ๋กœ ๋‹ค๋ฅธ ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์— ์†ํ•˜๋ฏ€๋กœ ๊ฐ๊ฐ ์•”๋“ฑ๋ก ํ•ด์•ผํ•˜๋Š”์ง€๋„ ์งˆ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.ํ™•์ธํ•˜์‹  ํ›„ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋†’์€ ์ฝ”๋“œ์ธ M8246/3 neuroendocrine carcinoma, NOS ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค. [2012 ์•”๋“ฑ๋ก์ง€์นจ P.44 ๋ณต์žกํ•ฉ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…] ๊ทœ์น™1. ์กฐํ•ฉ์ฝ”๋“œ - 2. ์ƒ์„ธ์ฝ”๋“œ - 3. ๋น„์ค‘(%) - 4. ๋†’์€ ์ฝ”๋“œ๋ฒˆํ˜ธ
abdomen ~ chest wall ์ข…๋ฌผ๋กœ ๋‚ด์›excision : Lipoblastoma, with size: 3.8x3cmLipoblastoma M8881/0*์ž„์ƒ์˜ ์˜๊ฒฌlipoblastoma๋Š” ๋ช…๋ฐฑํ•œ ํฌ๊ท€์•”์ž…๋‹ˆ๋‹ค. ๋…ผ๋ฌธ์—๋„ ์—ฌ๋ŸฌํŽธ ๋‚˜์™€์žˆ๋Š” ์žฌ๋ฐœ์„ฑ ์•”์ž…๋‹ˆ๋‹ค.์ผ๋ฐ˜์•…์„ฑ์ข…์–‘๋ณด๋‹ค๋Š” ์ˆ˜์ˆ ๋กœ ๊ฐ€๋” ์™„์น˜๊ฐ€ ๋˜์ง€๋งŒ, ์žฌ๋ฐœ์˜ ์œ„ํ—˜๋„๋„ ๋ถ„๋ช…ํžˆ ๋…ผ๋ฌธ์— ๋‚˜์™€์žˆ์Šต๋‹ˆ๋‹ค. *์˜์‚ฌ์ง„๋‹จ C49.4 ๋ณต๋ถ€์˜ ๊ฒฐํ•ฉ์กฐ์ง ๋ฐ ์—ฐ์กฐ์ง์˜ ์•…์„ฑ ์‹ ์ƒ๋ฌผ ์ด ๊ฒฝ์šฐ M8881/3 ์œผ๋กœ ์ฝ”๋“œ๋ฅผ ์ƒ์„ฑํ•˜์—ฌ ๋“ฑ๋กํ•˜๋ฉด ๋ ๊นŒ์š”?
์ž„์ƒ์˜ ์˜๊ฒฌ์—์„œ๋„ ํ™•์‹คํ•œ ์•…์„ฑ์•”์œผ๋กœ ํŒ๋‹จํ•˜๊ธฐ์—๋Š” ์–ด๋ ค์›€์ด ์žˆ์Šต๋‹ˆ๋‹ค. ์ž„์ƒ์˜๊ฐ€ ์•…์„ฑ์œผ๋กœ ์ง„๋‹จํ•œ ๋‚ด์šฉ์— ๋Œ€ํ•ด ๋ณ‘๋ฆฌ๊ธฐ๋ก๊ณผ ๋ถˆ์ผ์น˜ํ•œ ๋‚ด์šฉ์€ ํ™•์ธํ•ด๋ณด์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค. *์•”๋“ฑ๋ก์ž๋ฃŒ๋Š” ์งˆ๋ณ‘๋ถ„๋ฅ˜์™€ ๋‹ฌ๋ฆฌ ๊ตญ๊ฐ€์•”๋“ฑ๋กํ†ต๊ณ„์‚ฐ์ถœ์„ ๋ชฉ์ ์œผ๋กœ ์ˆ˜์ง‘ํ•ฉ๋‹ˆ๋‹ค.๋”ฐ๋ผ์„œ ํ™˜์ž์˜ ์งˆ๋ณ‘๋ถ„๋ฅ˜์™€๋Š” ๋ณ„๋„๋กœ ์•”๋“ฑ๋ก์‹œ์—๋Š” ์•”๋“ฑ๋ก ์ง€์นจ์„ ์‚ฌ์šฉํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
์„ ์ƒ๋‹˜ ,๋‹ค๋ฆ„์ด ์•„๋‹ˆ์˜ค๋ผ M์ฝ”๋“œ ๊ด€๋ จํ•ด์„œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.[ Name Of Operation ]Stomach, endoscopic submucosal dissection [ Pathological Diagnosis ]Epithelial dysplasia, low gradeโ—‡ Size: 1.4x0.8cmโ—‡ Resection margin: - Proximal: Free of dysplasia (safety margin: 0.6cm)- Distal: Free of dysplasia (safety margin: 0.6cm) - Greater curvature: Free of dysplasia (safety margin: 0.7cm)- Lesser curvature: Free of dysplasia (safety margin: 0.4cm)- Basal: Free of dysplasia (safety margin: 800ใŽ›)โ—‡ H. pylori: Absent โ—‡ ๋ณธ ์ง„๋‹จ์€ ์กฐ์ง๊ตฌ์ถ•ํ•™์  ๊ฒ€์‚ฌ ํ›„ ํŒ๋…๊ฒฐ๊ณผ์ž…๋‹ˆ๋‹ค. [ Gross Description ]The specimen consists of a piece of endoscopically dissected submucosal tissue, clinically from the posterior wall of antrum of stomach, measuring 2.4x2.3cm. All the submitted tissues are sent for tumor mapping.[INK CODE: proximal; blue, distal; green, greater curvature; yellow, lesser curvature; red, base; black]D13.1 ์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌํ–ˆ๋Š”๋ฐ, ํ˜น์‹œ M์ฝ”๋“œ๋Š” ๋ช‡๋ฒˆ์œผ๋กœ ๋ถ€์—ฌํ•˜๋ฉด ์ข‹์„์ง€ ์—ฌ์ญค๋ด๋„ ๋ ๊นŒ์š”.๋‹ค๋ฅธ D13.- ์ฝ”๋“œ๋Š” M์ฝ”๋“œ๊ฐ€ ํ™•์ธ๊ฐ€๋Šฅ ํ•œ๋ฐ D13.1์˜ ๊ฒฝ์šฐ์—๋Š” ์–ด๋””๋กœ ๋ถ€์—ฌํ•ด์•ผ ์ข‹์„์ง€ ํ™•์ธ์ด ์–ด๋ ค์›Œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค. ์งˆ๋ณ‘๋ถ„๋ฅ˜์— ๊ด€ํ•ด์„œ๋Š” ๋Œ€ํ•œ๋ณด๊ฑด์˜๋ฃŒ์ •๋ณด๊ด€๋ฆฌ์‚ฌํ˜‘ํšŒ์˜ ์ฝ”๋”ฉํด๋ฆฌ๋‹‰์— ๋ฌธ์˜ํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
~์•”๋“ฑ๋กํ•˜๋‹ค๊ฐ€ ๊ถ๊ธˆํ•œ ํ™˜์ž๊ฐ€ ์žˆ์–ด์„œ์š”~2022๋…„๋„ PIN high grade์˜€๋˜ ํ™˜์ž ์•”๋“ฑ๋ก์ดˆ์ง„์ผ์ž:2022-07-14T์ฝ”๋“œ :C61M์ฝ”๋“œ : 8148/2ICD 10 ์ฝ”๋“œ: D075๋ถ„ํ™”๋„: ํ•ด๋‹น์—†์Œseer : in situ ๋กœ ์คฌ์Šต๋‹ˆ๋‹ค2023๋…„๋„ 11์›” P-bx๊ฒฐ๊ณผ adenocarcinoma๋‚˜์™”๋Š”๋ฐ,M์ฝ”๋“œ๋Š” ์ดˆ์ง„ 4๊ฐœ์›”์ด ์ง€๋‚˜๋„ ์—…๋ฐ์ดํŠธ ํ•ด์ค˜์•ผ๋˜๋Š” ํ•ญ๋ชฉ์ด๋ฏ€๋กœ M8140/3 ์œผ๋กœ ์ฃผ๊ณ seer๋Š” ์ดˆ์ง„ 4๊ฐœ์›” ์ด๋‚ด ์—…๋ฐ์ดํŠธ๋œ ๋‚ด์šฉ๋งŒ ์ ์šฉ๋˜๋ฏ€๋กœ ๊ทธ๋Œ€๋กœ in situ๋กœ ๋‘๋ฉด ๋˜๋Š” ๊ฑธ๊นŒ์š”?in situ๋ฉด์„œ M์ฝ”๋“œ๋Š” ์•…์„ฑ์œผ๋กœ ์ €์žฅ์ด ๋˜๋ฏ€๋กœ ํ™•์ธ์ฐจ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋”๋ถˆ์–ด,์ดˆ์ง„ 4๊ฐœ์›” "์ด๋‚ด๋งŒ" ์ ์šฉ ํ•ญ๋ชฉ- ์น˜๋ฃŒ, seer, ์ „์ด๋ถ€์œ„์ดˆ์ง„ 4๊ฐœ์›” "์ดํ›„"์—๋„ ์—…๋ฐ์ดํŠธ- ์ตœ์ข…์ง„๋‹จ๋ฐฉ๋ฒ•, Grade, morphology, ์•”์‚ฌ๋ง์—ฌ๋ถ€, ์‚ฌ๋ง์ผ์ด๋ ‡๊ฒŒ ์ •๋ฆฌํ•ด๋‘์—ˆ๋Š”๋ฐ, ๋งž๋Š”์ง€๋„ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฌ๊ฒ ์Šต๋‹ˆ๋‹ค.
SEER์ฝ”๋“œ๋Š” '9๋ฒˆ(unknown)'์œผ๋กœ ์ฃผ์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค. ์ดˆ์ง„ 4๊ฐœ์›” "์ด๋‚ด๋งŒ" ์ ์šฉ ํ•ญ๋ชฉ: ์น˜๋ฃŒ, seer, ์ „์ด๋ถ€์œ„, stage์ด์™ธ ์ถ”๊ฐ€๋กœ ์ •๋ฆฌํ•ด์ฃผ์‹  ๋‚ด์šฉ ๋ชจ๋‘ ๋งž์Šต๋‹ˆ๋‹ค.
ํ์•”๋“ฑ๋ก๊ด€๋ จ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์ด ๋‚˜์˜จ ํ™˜์ž์ž…๋‹ˆ๋‹ค.Lung, right upper lobe, lobectomy after wedge resection ;1. Invasive adenocarcinoma , moderately differentiated,acinar (20%), papillary (40%), lepidic (10%), micropapillary (30%),single, 2x1x0.5cm, right upper lobe,with 1) confinement to lung (PL0) [pT1b [1, โ‰ค2cm]2) lymphovascular invasion : not identified3) perineural invasion : not identified4) parenchymal and bronchial margin: clear5) vascular margin: clear6) non-neoplastic lung : no diagnostic abnormality7) no metastasis in 32 lymph nodes (0/32) (pN0)(peribronchial lymph node : 0/6,#2 lymph node : 0/7,#4 lymph node : 0/5,#7 lymph node : 0/7,#10 lymph node : 0/3,#11 lymph node : 0/4)2. Squamous cell carcinoma, well differentiated, 0.5x0.3cm, right upper lobe,with 1) confinement to lung (PL0) [pT1a [โ‰ค1cm]2) lymphovascular invasion : not identified3) perineural invasion : not identified4) parenchymal and bronchial margin: clear5) vascular margin: clear๊ต์ˆ˜๋‹˜๊ป˜์„œ ์™ธ๋ž˜๊ธฐ๋ก์— Double primary Lung ca(ADC & SqCC, pT1cN0M0)๋ผ๊ณ ์ž‘์„ฑํ•˜์…จ๋Š”๋ฐ, ํ˜„์žฌ ์•”๋“ฑ๋ก์‹œ ์›๋ฐœ์žฅ๊ธฐ RUL ์—๋Š” ํ•˜๋‚˜์˜ ๋ชฐํด๋กœ์ง€๋งŒ ๋“ฑ๋ก๊ฐ€๋Šฅํ•˜์—ฌ์–ด๋–ป๊ฒŒ ๋“ฑ๋กํ•˜์—ฌ์•ผ ํ• ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ผ๊ณ  ๋ฌธ์˜๋“œ๋ฆฐ๊ธ€์— ๋‹ต๋ณ€์œผ๋กœ ๋‘ ์กฐ์งํƒ€์ž…์€ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์— ํ•ด๋‹นํ•˜์ง€ ์•Š์œผ๋ฏ€๋กœ ๊ฐ๊ฐ ๋“ฑ๋กํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.C341, M8260/3 (Papillary adenocarcinoma)C341, M8070/3 (Squamous cell carcinoma)๋ผ๊ณ  ๋‹ต๋ณ€์ฃผ์…จ๋Š”๋ฐ์š”~๊ฐ๊ฐ ๋“ฑ๋กํ•˜๋Š”๊ฑด ์•Œ๊ณ ์žˆ๋Š”๋ฐ, ์›๋ฐœ๋ถ€์œ„๊ฐ€ ๊ฐ™์€๋ฐ๋„ ๋‘๋ฒˆ ๋“ฑ๋ก์ด ๋˜๋‚˜์š”~?ํ˜„ ์‹œ์Šคํ…œ์ƒ ํ•œ ์›๋ฐœ๋ถ€์œ„์— ๋ชฐํด๋กœ์ง€ ํ•œ๊ฐœ๋งŒ ๋“ฑ๋ก์ด ๊ฐ€๋Šฅํ•˜์—ฌ ๋ฌธ์˜๋“œ๋ฆฐ๊ฒƒ์ž…๋‹ˆ๋‹ค~C341์—๋Š” ํ•œ๊ฐœ์˜ ๋ชฐํด๋กœ์ง€๋งŒ ๋“ฑ๋ก์ด ๊ฐ€๋Šฅํ•œ ์ƒํƒœ์ž…๋‹ˆ๋‹ค.
์‹œ์Šคํ…œ ๋ถ€๋ถ„์€ ๋ณ„๋„ ์œ ์„ ๋‹ต๋ณ€ ์ง„ํ–‰ํ•˜์˜€์Šต๋‹ˆ๋‹ค.
์•„๋ž˜ ๊ฒ€์‚ฌ๋ฅผ ํ†ตํ•ด P.vera ์ง„๋‹จ ๋ฐ›์•˜์Šต๋‹ˆ๋‹ค.JAK2 gene, Exon 12 Mutation[sequencing] JAK-2 V617F Mutation์•”๋“ฑ๋ก ํ•˜๋ ค๊ณ  ํ•˜๋Š”๋ฐ ์ตœ์ข… ์ง„๋‹จ๋ฐฉ๋ฒ•์„ 5. ์„ธํฌํ•™์  ๋˜๋Š” ํ˜ˆ์•กํ•™์  ๊ฒ€์‚ฌ๋กœ ํ•˜๋ฉด ๋ ๊นŒ์š”?
ํ•ด๋‹น ๊ฒ€์‚ฌ๋งŒ์œผ๋กœ ์ง„๋‹จ ๋ฐ›๊ธฐ๋Š” ์–ด๋ ต์Šต๋‹ˆ๋‹ค. ์ถ”๊ฐ€๋กœ Bone marrow ์กฐ์ง๊ฒ€์‚ฌ ๋‚ด์šฉ์ด ์—†๋Š”์ง€ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
์ˆ˜๊ณ ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค.1.Pancreas tail cancer ํ™˜์ž CT์ธ๋ฐ SEER ๋ฌธ์˜๋“œ๋ฆฌ๊ณ ์ž ๊ธ€ ๋‚จ๊น๋‹ˆ๋‹ค.[Impression]1. Grossly no change of a 5.4cm sized multiseptated cystic lesion with enhancing solid portions in the pancreatic tail portion ; main duct dilatation(1.3cm in long diameter) ; abutment of stomach upper body and left adrenal gland์œ„ ํŒ๋…์—์„œ "abutment of"๋ฅผ Extension to์˜ ์˜๋ฏธ๋กœ SEER๋ฅผ 7์œผ๋กœ ๋“ฑ๋กํ•ด๋„ ๋ ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.2. Nasal cavity cancer ๋ณ‘๋ฆฌ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ์ธ๋ฐ ๋ชฐํด๋กœ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. Nasal cavity, right, excision: Hybrid carcinoma of myoepithelial carcinoma and squamous cell carcinoma (see note) with involved excisional margin ์ธ๋ฐ myoepithelial carcinoma (M8982/3), squamous cell carcinoma (M8070/3) ๊ฐ๊ฐ ๋“ฑ๋กํ•˜๋ฉด ๋ ๊นŒ์š” ? Hybrid carcinoma๋กœ ๋ถ„๋ฅ˜๋˜๋Š” ๋ชฐํด๋กœ์ง€๊ฐ€ ์—†์–ด์„œ ์งˆ๋ฌธ๋“œ๋ ค์š”. ๋ฏธ๋ฆฌ ๋‹ต๋ณ€ ๊ฐ์‚ฌ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ใ…Ž^^ใ…Ž
"abutment of"๋Š” Extension to์˜ ์˜๋ฏธ๋กœ ๋ณด๊ธฐ์—๋Š” ์–ด๋ ต์Šต๋‹ˆ๋‹ค. ๋ช…ํ™•ํ•œ ์นจ๋ฒ”์ •๋„๋ฅผ ์•Œ ์ˆ˜ ์žˆ๋Š” ์˜์ƒ๊ฒ€์‚ฌ ์ž๋ฃŒ๊ฐ€ ์žˆ๋Š”์ง€ ์ถ”๊ฐ€๋กœ ํ™•์ธํ•ด์ฃผ์„ธ์š”.[์ฐธ๊ณ ]SEER summary staging manual 2000. p.15 'Interpreting Ambiguous Terminology for Summary Stage
M ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.์กฐ์ง๋ณ‘๋ฆฌ ๊ฒฐ๊ณผ๋กœ Meninges, spheno-temporal, right, tumor removal; En plaque meningioma, WHO grade IEn plaque meningioma,์˜ M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹คmeningioma NOS ์ธ M9530/0์œผ๋กœ ํ•˜๋ฉด ๋˜๋Š”์ง€์š”?๋ฐ”์˜์‹œ๊ฒ ์ง€๋งŒ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋„ค, M9530/0 (Meningioma, NOS)๋กœ ์ฝ”๋”ฉํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
ํ์•”๋“ฑ๋ก๊ด€๋ จ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์ด ๋‚˜์˜จ ํ™˜์ž์ž…๋‹ˆ๋‹ค. Lung, right upper lobe, lobectomy after wedge resection ; 1. Invasive adenocarcinoma , moderately differentiated, acinar (20%), papillary (40%), lepidic (10%), micropapillary (30%), single, 2x1x0.5cm, right upper lobe, with 1) confinement to lung (PL0) [pT1b [>1, โ‰ค2cm] 2) lymphovascular invasion : not identified 3) perineural invasion : not identified 4) parenchymal and bronchial margin: clear 5) vascular margin: clear 6) non-neoplastic lung : no diagnostic abnormality 7) no metastasis in 32 lymph nodes (0/32) (pN0) (peribronchial lymph node : 0/6, #2 lymph node : 0/7, #4 lymph node : 0/5, #7 lymph node : 0/7, #10 lymph node : 0/3, #11 lymph node : 0/4) 2. Squamous cell carcinoma, well differentiated, 0.5x0.3cm, right upper lobe, with 1) confinement to lung (PL0) [pT1a [โ‰ค1cm] 2) lymphovascular invasion : not identified 3) perineural invasion : not identified 4) parenchymal and bronchial margin: clear 5) vascular margin: clear ๊ต์ˆ˜๋‹˜๊ป˜์„œ ์™ธ๋ž˜๊ธฐ๋ก์— Double primary Lung ca(ADC & SqCC, pT1cN0M0)๋ผ๊ณ  ์ž‘์„ฑํ•˜์…จ๋Š”๋ฐ, ํ˜„์žฌ ์•”๋“ฑ๋ก์‹œ ์›๋ฐœ์žฅ๊ธฐ RUL ์—๋Š” ํ•˜๋‚˜์˜ ๋ชฐํด๋กœ์ง€๋งŒ ๋“ฑ๋ก๊ฐ€๋Šฅํ•˜์—ฌ ์–ด๋–ป๊ฒŒ ๋“ฑ๋กํ•˜์—ฌ์•ผ ํ• ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๋‘ ์กฐ์งํƒ€์ž…์€ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์— ํ•ด๋‹นํ•˜์ง€ ์•Š์œผ๋ฏ€๋กœ ๊ฐ๊ฐ ๋“ฑ๋กํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค. C341, M8260/3 (Papillary adenocarcinoma)C341, M8070/3 (Squamous cell carcinoma)
๋‡Œ์ข…์–‘ ์ˆ˜์ˆ  ํ›„ ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ ์ž…๋‹ˆ๋‹ค.1. Integrated diagnosis: Low grade glioma with focal features of subependymal giant cell astrocytoma (Subependymal giant cell astrocytoma-like astrocytoma), NF1 associated2. Histological classification: Low grade glioma with focal features of subependymal giant cell astrocytoma3. CNS WHO grade: 2์•…์„ฑ์ด ์šฐ์„ ์ด๋‹ˆ Glioma(M9380/3) ๋กœ ์ฃผ์–ด์•ผ ํ•  ๊ฒƒ ๊ฐ™์€๋ฐ..Low grade glioma ์ด๋ฉฐ CNS WHO grade: 2 ์—ฌ์„œ, subependymal giant cell astrocytoma(M9384/1)๋กœ ๋“ฑ๋กํ•˜๋Š” ๊ฒƒ์ด ๋” ์ •ํ™•ํ•œ๊ฒŒ ์•„๋‹Œ์ง€ ๋ชจ๋ฅด๊ฒ ์Šต๋‹ˆ๋‹ค.ํ™•์ธ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M9380/3 Glioma, NOS(C71._)(except nasal glioma: not neoplastic)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
ํ•ด๋‹น ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ์กฐ์ง๊ฒ€์‚ฌ ์ดํ›„ ๊ต์ˆ˜๋‹˜ ์™ธ๋ž˜ F/U ๊ธฐ๋ก ์ƒ "Sarcoma(rt. infrascapular area)"์œผ๋กœ ํ™•์ธ๋ฉ๋‹ˆ๋‹ค.Myxosarcoma (M8840/3) ์œผ๋กœ ๋ถ€์—ฌํ•˜๋ฉด ๋ ์ง€์š”?โ—† ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ[ DIAGNOSIS ]Soft tissue, infrascapular area, right, needle biopsy; Myxoid spindle cell tumor with uncertain malignant potential, SEE NOTENOTE) Differential diagnosis includes low-grade fibromyxoid sarcoma, myxoid liposarcoma,intramuscular myxoma, etc.[ ADDITIONAL STUDIES ]The results of immunohistochemical staining of tumor cells(A01); CD34: positive, weak SMA: positive, focal and weak Desmin: negative S-100: negative SOX10: negative STAT6: negative MUC4: negative
๋ณด๋‚ด์ฃผ์‹  ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋งŒ์œผ๋กœ๋Š” ํ™•์ธ์ด ์–ด๋ ต์Šต๋‹ˆ๋‹ค. ์ตœ์ข…์ง„๋‹จ์— 'Sarcoma'๋กœ ์ฃผ์‹  ๊ทผ๊ฑฐ๋ฅผ ํ™•์ธํ•ด์ฃผ์„ธ์š”.
์ˆ˜๊ณ  ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค.ํ์•”์˜ ์กฐ์งํƒ€์ž…์„ ๋ฌป๋Š” ์งˆ์˜์— ๋Œ€ํ•œ ์˜๋ฌธ์  ์žˆ์–ด ์งˆ์˜ ์˜ฌ๋ฆฝ๋‹ˆ๋‹ค.๋‹ต๋ณ€ ์ฃผ์‹  2๋ฒˆ์˜ ํ์•” ์กฐ์งํƒ€์ž…์ด M8254/3์œผ๋กœ ๋˜์–ด ์žˆ์–ด์„œ ์ค‘๊ธ‰์ž๋ฃŒ 223์— ์„ค๋ช…์ž๋ฃŒ์— subtype+other type์ผ ๊ฒฝ์šฐ์—๋Š” other type์€ ์ œ์™ธ๋ผ๊ณ  ๋˜์–ด ์žˆ์–ด์„œ ์ด ๊ฒฝ์šฐ์—๋„ mixed mucinous and non-mucinous๋Š” other type์œผ๋กœ ๋ณด๊ณ  ์ œ์™ธ์‹œ์ผœ์•ผ ํ•˜๋Š”๊ฒŒ ์•„๋‹Œ๊ฐ€ ์‹ถ์–ด ๋ฌธ์˜ํ•ฉ๋‹ˆ๋‹ค.๊ทธ๋ž˜์„œ subtype์ธ M8255/3์œผ๋กœ ๋ถ„๋ฅ˜ํ•ด์•ผ ํ• ๊ฑฐ ๊ฐ™์•„ ๋ฌธ์˜ํ•ฉ๋‹ˆ๋‹ค.๊ทธ๋ฆฌ๊ณ  ํ•œ๊ฐ€์ง€ ๋” ๋ฌป์ž๋ฉด ์•”๋“ฑ๋ก ๊ต์œก์ž๋ฃŒ ์ค‘๊ธ‰๊ต์œก์ž๋ฃŒ223 ์ค‘๊ธ‰๊ณผ์ •FAQ ์— 20์ชฝ ์Šฌ๋ผ์ด๋“œ์™€ 21์ชฝ ์Šฌ๋ผ์ด๋“œ์˜ ์˜ˆ์ œ2๊ฐ€ ๋˜‘๊ฐ™์€๊ฑฐ ๊ฐ™์€๋ฐ ๋‹ต์ด ๋‹ฌ๋ผ์„œ ๋ฌธ์˜ํ•ฉ๋‹ˆ๋‹ค.
'ํ์•” ๊ทœ์น™-M8255/3'์€ ๊ธฐ๋ณธ ์ „์ œ๊ฐ€ 'Adenocarcinoma'์ธ ๊ฒฝ์šฐ์—๋งŒ ํ•ด๋‹นํ•ฉ๋‹ˆ๋‹ค. ๊ธฐ์กด 2664 ์งˆ์˜ ๋‚ด์šฉ๊ณผ๋Š” ์ƒ์ดํ•œ ์ •๋ณด์ž…๋‹ˆ๋‹ค. ๋˜ํ•œ ์ค‘๊ธ‰๊ต์œก๊ณผ์ • FAQ ๋‚ด์šฉ์— ๋Œ€ํ•œ ์ถ”๊ฐ€์„ค๋ช…์€ ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค. p20. ์Šฌ๋ผ์ด๋“œ ์˜ˆ2) Adenocarcinoma(lepidic 70%, acinar 30%) : M8250/3 "Only Subtype"์— ํ•ด๋‹นํ•˜๋Š” type๋“ค์€ %๊ฐ€ ์žˆ์„ ๊ฒฝ์šฐ ๋†’์€ % ์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌํ•ฉ๋‹ˆ๋‹ค.P21. ์Šฌ๋ผ์ด๋“œQ1) Lung, left lower lobe, lobectomy: Adenocarcinoma, M/D, acinar and lepidic type "Only Subtype"์— ํ•ด๋‹นํ•˜๋Š” type๋“ค ์ด์ง€๋งŒ, %๊ฐ€ ์—†์œผ๋ฏ€๋กœ Mixed ์ฝ”๋“œ์ธ M8255/3 ์œผ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
Pancreas, body, EUS-fine needle biopsy:#1, 1-Suction: Adenocarcinoma, with squamous cell carcinoma differentiated. #2, 2-Capillary suction: Adenocarcinoma, with squamous cell carcinoma differentiated. ์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๊ฐ€ ์œ„์™€ ๊ฐ™์ด ๋‚˜์˜จ ๊ฒฝ์šฐ M์ฝ”๋“œ๊ฐ€ ์–ด๋–ป๊ฒŒ ๋˜๋‚˜์š” ? ๋ณต์žกํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ๊ทœ์น™ 3๋ฒˆ์ข…์–‘์˜ ๋Œ€๋ถ€๋ถ„์„ ์ฐจ์ง€ํ•˜๋Š” ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์œผ๋กœ ์ฝ”๋”ฉํ•œ๋‹ค. -์ข…์–‘์˜ ๋Œ€๋ถ€๋ถ„์„ ์ง€์นญํ•˜๋Š” ์šฉ์–ด "with ...differentiation" ์ด ๊ทœ์น™ ์ ์šฉํ•˜์—ฌ Squamous cell carcinoma 8070/3 ๋กœ ์ฝ”๋”ฉํ•ด์•ผํ• ๊นŒ์š”? 1. ์œ„ ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ์˜ ๊ฒฝ์šฐ ๊ทœ์น™3๋ฒˆ ์ ์šฉ๋˜๋Š” ์ผ€์ด์Šค์ธ์ง€? 2. ์œ„ ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์˜ ๊ฒฝ์šฐ M์ฝ”๋“œ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค
์ค‘์•™์•”๋“ฑ๋ก๋ณธ๋ถ€์—์„œ ์ž๋ฌธ๋ฐ›์€ ์˜๊ฒฌ์€ ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.์ด ์ฆ๋ก€์˜ ๊ฒฝ์šฐ ์ผ๋‹จ Adenocarcinoma๊ฐ€ ์žˆ๊ณ  squamous cell carcinoma ๋ถ€๋ถ„์ด ์žˆ๋‹ค๋Š” ๊ฒƒ์œผ๋กœ ๋ณด๋Š” ๊ฒƒ์ด ๋” ํƒ€๋‹นํ•  ๊ฒƒ์œผ๋กœ ๋ณด์ž…๋‹ˆ๋‹ค. ์ด ๊ฒฝ์šฐ ๋ช…ํ™•ํ•œ criteria๊ฐ€ ์žˆ๋Š” ๊ฒƒ์€ ์•„๋‹ˆ๋‚˜ Adenosquamous carcinoma๋กœ ํ•˜๋ ค๋ฉด squamous cell carcinoma ๋ถ€๋ถ„์ด ์ ์–ด๋„ 30% ์ด์ƒ์€ ๋˜์–ด์•ผ ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜์™€ ์žˆ๊ธฐ๋Š” ํ•ฉ๋‹ˆ๋‹ค. ์ด ์ฆ๋ก€๋Š” ์ „์ฒด ์ข…์–‘ ์ค‘ ์–ผ๋งˆ๋งŒํผ์”ฉ ์„ž์—ฌ์žˆ๋Š”์ง€ ํ™•์‹คํ•˜์ง€ ์•Š์•„ ํ™•์‹คํ•˜๊ฒŒ ํ•˜๊ธฐ๋Š” ์ข€ ์–ด๋ ต์ง€๋งŒ ๋‘ ๋ฒˆ์˜ ๊ฒ€์‚ฌ์—์„œ ๋ชจ๋‘ ์–‘์ชฝ ์„ฑ๋ถ„์ด ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ํ™•์ธ๋ฉ๋‹ˆ๋‹ค. ์ด์— ๊ธฐ์ˆ ํ•œ ๋ณ‘๋ฆฌ์˜์‚ฌ์—๊ฒŒ 'Adenocarcinoma'์ธ์ง€ 'Adenosqumous carcinoma' ์ธ์ง€ ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.
, Breast cancer ์•”๋“ฑ๋ก์— ๋Œ€ํ•ด ๋ฌธ์˜์‚ฌํ•ญ ์žˆ์–ด ๊ธ€ ๋‚จ๊น๋‹ˆ๋‹ค.DIAGNOSIS: Breast, left nipple, excision: DUCTAL CARCINOMA IN SITU associated with Paget's disease 1) Post-lumpectomy status 2) Size of tumor: 1.0cm (pTis(Paget)) ... 10) Pathological TN category (AJCC 2017): pTis(Paget)Nx 1)ํ•ด๋‹น ๋ณ‘๋ฆฌ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ์— ๋”ฐ๋ผ ํ˜•ํƒœํ•™ ์ฝ”๋“œ 8543/3 ๋ถ€์—ฌํ•˜๋Š” ์ ์€ ํ™•์ธํ•˜์˜€์œผ๋‚˜, 8543/3 ์œผ๋กœ ์•”๋“ฑ๋ก ์‹œ GRADE , SEER , TNM ์„ /3 ์— ๋Œ€ํ•œ ๊ธฐ์ค€์œผ๋กœ ๋ถ€์—ฌํ•ด์•ผํ•˜๋Š”์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค. 2)/3 ๊ณผ pTis(Paget)NX ์ž…๋ ฅ ์‹œ ๋งคํฌ๋กœ ์˜ค๋ฅ˜์— ๊ฑธ๋ฆฌ์ง€๋Š” ์•Š๋Š”์ง€๋„ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.ํ•ด๋‹น ๋‚ด์šฉ ํ™•์ธํ•˜์‹œ์–ด ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M8543/3(Paget disease and intraductal carcinoma of breast)๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค. ์•”๋“ฑ๋ก ์‹œ ์•…์„ฑ์•”์— ๋Œ€ํ•œ ๊ธฐ์ค€์œผ๋กœ GRADE, SEER๋ฅผ ๋ถ€์—ฌํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค. ์ฃผ์–ด์ง„ stage ์ •๋ณด๋ฅผ ๊ธฐ์ž…ํ•ด์ฃผ์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค. (๋น„๊ณ ๋ž€์— bx ๊ฒฐ๊ณผ ๊ธฐ์žฌ๋ฐ”๋ž๋‹ˆ๋‹ค.)
ํƒ€๋ณ‘์›์—์„œ ๊ฐ€์ ธ์˜จ ์˜๋ขฐ์„œ์— rectum carcinoma in situ ๋งŒ ๊ธฐ์žฌ๋˜์–ด ์žˆ์œผ๋ฉฐ,์ง„๋‹จ๋ฐฉ๋ฒ•์— ๋Œ€ํ•œ ์ •๋ณด๊ฐ€ ์—†์–ด์„œ ์ง„๋‹จ ๋ฐฉ๋ฒ•์„ 1๋กœ ์ค€๋‹ค๋ฉด ์กฐ์งํ•™์  ์ง„๋‹จ์€ M8010/2์ด์ง€๋งŒ ์•”๋“ฑ๋ก ์‹œ์—๋Š” ์–ด๋–ป๊ฒŒ ์ฃผ๋ฉด๋˜๋‚˜์š”?
M8010/2 ์ฝ”๋“œ๋Š” '๋น„ํ˜„๋ฏธ๊ฒฝ์  ๋ฐฉ๋ฒ•์œผ๋กœ ์ง„๋‹จ์‹œ ์ธ์ •๋˜๋Š” 22๊ฐœ์˜ ์กฐ์งํ•™์  ์†Œ๊ฒฌ'์— ํ•ด๋‹น๋˜์ง€ ์•Š์œผ๋ฏ€๋กœ M8000/2๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค. (ํ•ด๋‹น๋‚ด์šฉ์€ ๋น„๊ณ ๋ž€์— ๊ธฐ์ž…ํ•ด์ฃผ์„ธ์š”)
. ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์ƒ ์•„๋ž˜์™€ ๊ฐ™์ด ํ™•์ธ๋ฉ๋‹ˆ๋‹ค. Endometrioid carcinoma - Procedure: total hysterectomy, bilateral salpingo-oophorectomy, pelvic LND and omentectomy - Tumor site: lower uterine segment - Tumor size: 10.7x7.5cm - Histologic type and FIGO grade: Endometrioid carcinoma, grade 3, with neuroendocrine differentiation - Depth of invasion (pT2) - Myometrial invasion: present, one half or more (9mm/14mm (myometrial thickness)) - Invades cervical stroma (10mm/19mm (cervical thickness)) - Resection margins: free from carcinoma (Distance of invasive carcinoma from exocervical margin: 0.3cm) - Lymph node metastasis: no metastasis in 18 lymph nodes (0/18) (pN0) Rt.pelvic LN(0/14) Lt.pelvic LN(0/4) - Lymphovascular Space Invasion: focal(<5), deep myometrial - Additional findings: Endometrioid intraepithelial neoplasia - 2023 FIGO staging: IIc------------------------------------------------------------------------ Endometrioid carcinoma, grade 3, with neuroendocrine differentiation M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. KCD 8์ฐจ ๊ฐœ์ •์ƒ์—๋Š” carcinoma - endometriod - with squamous differentiation ์€ ์žˆ์œผ๋‚˜ neuroendocrine differentiation์€ ํ™•์ธ๋˜์ง€ ์•Š์•„ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
M8380/3 (Endometrioid carcinoma)๋กœ ์ฝ”๋”ฉํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
๊ฐ‘์ƒ์„ ์•” ํ™˜์ž์ž…๋‹ˆ๋‹ค. ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์ƒPapillary microcarcinoma, encapsulated๋ณด๊ณ ๋˜์–ด M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
M8343/3 (Papillary carcinoma, encapsulated, of thyroid)๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผoral mucosa, tongue : squamous dysplasia , high grade๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค.์•”๋“ฑ๋ก ๋Œ€์ƒ(์ œ์ž๋ฆฌ์•”) ์—ฌ๋ถ€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. high grade๋ฅผ /2๋กœ ์ธ์ •ํ•˜์ง€ ์•Š๋Š” ๋ถ€์œ„๋ผ์„œ ์ œ์ž๋ฆฌ์•”์ด ์•„๋‹ˆ๋ผ๋ฉด, ์–ด๋–ค ์ฝ”๋“œ๋กœ ๋ด์•ผํ• ์ง€๋„ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
Tongue์€ High grade dysplasia์˜ ํ–‰ํƒœ์ฝ”๋“œ๋ฅผ /2๋กœ ์ธ์ •ํ•˜๋Š” ์›๋ฐœ๋ถ€์œ„๊ฐ€ ์•„๋‹™๋‹ˆ๋‹ค. ์ฃผ์น˜์˜์™€ ์ƒ์˜ ํ›„ ๊ฒฐ์ •ํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค.[์•”๋“ฑ๋ก ์ง€์นจ ๋ณ€๊ฒฝ ๋ฐ ์ฃผ์š”์‚ฌํ•ญ ๊ณต์ง€ (2014) , 1) High grade dysplasia / neoplasia ๋‚ด์šฉ์ฐธ๊ณ ]์ƒํ”ผ๋‚ด์•” ์ง„๋‹จ์ด ์•„๋‹ˆ๋ผ๋ฉด ์•”๋“ฑ๋ก๋Œ€์ƒ ์•„๋‹™๋‹ˆ๋‹ค.
HIPEC(Hyperthemic intraperitoneal Chemotherapy) ์น˜๋ฃŒ ๊ด€๋ จ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค!HIPEC์€ ์ˆ˜์ˆ ์‹ค์—์„œ ๊ณ ์˜จ์˜ ํ•ญ์•”์ œ๋ฅผ ๋ณต๋ถ€์— ์ฃผ์ž…(๋ณต๊ฐ•๋‚ด ์˜จ์—ด ํ•ญ์•”ํ™”ํ•™์š”๋ฒ•)ํ•˜๋Š” ํ˜•ํƒœ๋กœ ์ง„ํ–‰๋˜๋Š” ์น˜๋ฃŒ๋กœ, ๋‹จ๋…์œผ๋กœ ์ง„ํ–‰ํ–ˆ์„ ๋•Œ์™€ ๋‹ค๋ฅธ ์ˆ˜์ˆ ๊ณผ ํ•จ๊ป˜ ์ง„ํ–‰๋˜์—ˆ์„ ๋•Œ ์น˜๋ฃŒ ํ˜•ํƒœ๋ฅผ ์ˆ˜์ˆ ๊ณผ ํ•ญ์•”์— ๋ชจ๋‘ ์—…๋ฐ์ดํŠธ ํ•ด์•ผํ•˜๋Š”์ง€ ์•„๋‹ˆ๋ฉด ์น˜๋ฃŒ๋‚˜ ์ˆ˜์ˆ  ์ค‘ ํ•˜๋‚˜์—๋งŒ ์—…๋ฐ์ดํŠธ ํ•ด์•ผํ•˜๋Š”์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค :)
ํ•ญ์•”์น˜๋ฃŒ๋กœ ๋ถ„๋ฅ˜ํ•ฉ๋‹ˆ๋‹ค.
Stomach, lesser curvature of body, radical subtotal gastrectomy: Adenocarcinoma with mixed subtypes - Tubular adenocarcinoma, moderately differentiated (60%) - Tubular adenocarcinoma, poorly differentiated (30%) - Signet-ring cell carcinoma (10%)์œ„์•” ์กฐ์ง๊ฒ€์‚ฌ ์œ„์™€๊ฐ™์ด ํ™•์ธ๋˜์—ˆ์Šต๋‹ˆ๋‹คM์ฝ”๋“œ M8255/3(Adenocarcinoma with mixed subtypes)์œผ๋กœ ํ™•์ธ ํ•ด์•ผํ• ์ง€M8211/3(Tubular adenocarcinoma) ์œผ๋กœ ํ™•์ธ ํ•ด์•ผํ• ์ง€ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฌ๊ฒ ์Šต๋‹ˆ๋‹ค~
M8211/3 (Tubular adenocarcinoma) ์œผ๋กœ ์ฝ”๋”ฉํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.(2012 ์•”๋“ฑ๋ก์ง€์นจ- P.44 ๋ณต์žกํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ๊ทœ์น™- '3.์ข…์–‘์˜ ๋Œ€๋ถ€๋ถ„์„ ์ฐจ์ง€ํ•˜๋Š” ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…' ๊ทœ์น™ ์‚ฌ์šฉ)
์œ ๋ฐฉ์•” ํ˜•ํƒœํ•™ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.DIAGNOSIS: Breast, right 10 o'clock, needle biopsy: Ductal carcinoma in situ involving intraductal papilloma ===============================================ํ•ด๋‹น case์˜ ๊ฒฝ์šฐ, ์•„๋ž˜ M์ฝ”๋“œ ์ค‘ ์–ด๋–ค ํ˜•ํƒœํ•™์„ ๋ถ€์—ฌํ•˜๋ฉด ๋ ์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค1) 8500/2 : Intraductal carcinoma, noninfiltrating NOS2) 8503/2 : Noninfiltrating intraductal papillary adenocar- cinoma
M8503/2 (Intraductal papilloma with DCIS) ๋กœ ์ฝ”๋”ฉํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
.์กฐ์งํ•™์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.[DIAGNOSIS]Lung, LUL, CT Chest Guide Biopsy;Non-small cell carcinoma with spindle cell and/or giant cell carcinoma.[COMMENT]Spindle cell์ด cytokeratin ๋ฉด์—ญ์กฐ์งํ™”ํ•™์  ์—ผ์ƒ‰์— ์–‘์„ฑ์œผ๋กœ Spindle cell carcinoma์— ํ•ฉ๋‹นํ•˜์ง€๋งŒ, ์ƒ๊ฒ€์กฐ์ง์˜ ํ•œ๊ณ„๋กœ adenocarcinoma๋‚˜ squamous cell carcinoma์ด ๋™๋ฐ˜๋œ Pleomorphic carcinoma์˜ ๊ฐ€๋Šฅ์„ฑ์„ ์™„์ „ํžˆ ๋ฐฐ์ œํ•  ์ˆ˜๋Š” ์—†์Šต๋‹ˆ๋‹ค. ์™„์ „ ์ ˆ์ œ๋กœ ํ™•์ง„์ด ๊ฐ€๋Šฅํ•  ๊ฒƒ์œผ๋กœ ์‚ฌ๋ฃŒ๋ฉ๋‹ˆ๋‹ค.์ตœ์ข…์ง„๋‹จ NSCLC(spindle cell ca, cT4N3M1c, stage IVB) ์ด๋ ‡๊ฒŒ ๊ธฐ์žฌํ•ด ์ฃผ์…จ์Šต๋‹ˆ๋‹ค. M8046/3 ์œผ๋กœ ๋“ฑ๋กํ•ด์•ผ ๋ ์ง€์š”?
M8032/3 (Spindle cell carcinoma)๋กœ ์ฝ”๋”ฉํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
2021.07.15. bx.Labeled left chest wall mass, excision: Angiosarcoma, high grade 1. Nuclear atypia: severe 2. Necrosis: absent 3. Mitosis: 10-12/10HPF (atypical mitosis is noted) 4. Surgical margins: involved by tumor 5. Lymphovascular invasion: absent2021.08.09. bx.Skin and soft tissue, chest wall, wide excision Malignancy, s/p excision for angiosarcoma of chest wall; consistent with residual angiosarcoma - Surgical margin: free from tumor cells (based on fronzen section and more resection)2022.07.06. bx.Skin, mass on trunk S/P angiosarcoma, excisional biopsy: Malignancy; Consistent with recurrent angiosarcoma, s/p excision for angiosarcoma of chest wall - Resection margin: involved by tumor cells2022.07.18. bx. Skin and soft tissue, chest wall, wide excision: - A few atypical cells in dermis, consistent with residual angiosarcoma, focal, microscopic size (s/p excision for angiosarcoma since 2021; S21-14846, S22-13039) with clear resection margin - Foreign body reaction2023.01.19. bx.Skin and soft tissue, breast (chest), excision: C/W, Angiosarcoma with foreign body reaction 1) Size: 1.2 x 0.8 x 0.8cm 2) Resection margins: - deep margin: abut and focal involved - 12์‹œ: abut and focal involved - 3์‹œ: abut and focal involved - 6์‹œ: abut and focal involved2023.07.03. bx.Skin, chest, left, excisional biopsy: Angiosarcoma, high grade, recurrent (s/p wide excision for angiosarcoma; S23-01318) with 1) involved resection margins 2) labeled "wound base": involved by tumor cells2023.10.13. bx.Skin, chest, left, excisional biopsy and coverage with advancement flap: Angiosarcoma, high grade 1. Size: 4.5 x 3.1 x 1.5cm 2. Lymphovascular invasion: absent 3. Mitosis: 20 / 10 HPF 4. Resection margins: - Involved by tumor (deep margin) - free from tumor (safety margin: 0.05cm from 6์‹œ, 9์‹œ, 0.3cm from 12์‹œ)Labeled muscle base, excisional biopsy and coverage with advancement flap: Positive for tumor cells, focal 1. Size: 0.2cmํ™˜์ž 21๋…„๋„ ์›๋ฐœ๋ถ€์œ„ C49.3, M9120/3 ์œผ๋กœ ์•”๋“ฑ๋ก์„ ํ•œ ํ™˜์ž์ž…๋‹ˆ๋‹ค.2023.01.19. bx. ๊ฒฐ๊ณผ๋กœ ์˜์‚ฌ๊ฐ€ C50 ์œผ๋กœ M9120/3 ์„ ์คฌ๋Š”๋ฐ์š”. C50์„ M9120/3 ์— ์›๋ฐœ๋กœ ์ค˜๋„ ๋ ๊นŒ์š”? C44.5 ๋ฅผ ์›๋ฐœ๋กœ ์•ˆ๋‚ดํ•ด์•ผ ํ•˜์ง€ ์•Š์„๊นŒ์š”?
์žฌ๋ฐœ์•”์€ ๋“ฑ๋ก๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค. ๊ธฐ์กด ์•”๋“ฑ๋ก ํ•œ ์ž๋ฃŒ๋ผ๋ฉด ์ถ”๊ฐ€ ๋“ฑ๋ก์€ ํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค.
์ˆ˜๊ณ ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค Lung, RLL, biopsy:Adenocarcinoma with micropapillary pattern.์ด๊ฒฝ์šฐ M82653์กฐ์งํ•™์ ์ง„๋‹จ์ฝ”๋“œ๋กœ ์ž…๋ ฅํ•˜๋ฉด TM๊ณผ ๋ถˆ์ผ์น˜ํ•ด์„œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค
ํ•ด๋‹น ์›๋ฐœ๋ถ€์œ„์™€ ์กฐ์งํ•™์ ์ง„๋‹จ๋ช…์€ ์˜ค๋ฅ˜ ์—†์ด ๋“ฑ๋ก ๊ฐ€๋Šฅํ•ฉ๋‹ˆ๋‹ค.[์•”๋“ฑ๋กํ†ต๊ณ„์‹œ์Šคํ…œ-๊ณต์ง€์‚ฌํ•ญ]์—์„œ ์ตœ์‹  ์˜ค๋ฅ˜์ฒดํฌ๋งคํฌ๋กœ ํŒŒ์ผ์„ ๋‹ค์šด๋ฐ›์•„ ์‚ฌ์šฉํ•˜์‹œ๊ธฐ๋ฐ”๋ž๋‹ˆ๋‹ค. (2023.6.15. "2021๋…„ ์•”๋ฐœ์ƒํ†ต๊ณ„์ž๋ฃŒ ์˜ค๋ฅ˜์ฒดํฌ๋งคํฌ๋กœ")
. 1. Uterus, hysterectomy:*MICROSCOPIC TUMOR DESCRIPTION 1) Tumor site: exocervix to lower uterine segment, whole o'clock direction2) Histologic type: Squamous cell carcinoma, HPV-associated, with neuroendocrine and sarcomatoid differentiation ์ผ ๋•Œ, ์›๋ฐœ๋ถ€์œ„ ์ฝ”๋“œ์™€ ๋ชฐํด๋กœ์ง€ ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. 2. Lung, lower lobe, left, lobectomy 1) Histologic type: Mixed invasive mucinous (60%) and non-mucinous (40%) adenocarcinoma (Histologic patterns - Papillary: 50%, Micropapillary: 30%, Solid: 20%) ์ผ ๊ฒฝ์šฐ, ๋ชฐํด๋กœ์ง€ ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
1. ์›๋ฐœ๋ถ€์œ„๋Š” Exocervix์— ๊ตญํ•œ๋œ ๊ฒƒ์œผ๋กœ ๋ณด์ด์ง€ ์•Š์œผ๋ฏ€๋กœ C53.9(Cervix, NOS)๋กœ ๋ถ€์—ฌํ•ฉ๋‹ˆ๋‹ค. ์กฐ์งํ•™์ ์ง„๋‹จ๋ช…์€ HPV ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๋ฅผ ํ™•์ธ ๋ฐ ๋ฐ˜์˜ํ•˜์—ฌ ์ฝ”๋“œ ๋ถ€์—ฌํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.2. M8254/3 (Adenocarcinoma of lung, mixed mucinous and non-mucinous(C34._))์œผ๋กœ ๋ถ€์—ฌํ•ฉ๋‹ˆ๋‹ค.
Greater curvature to anterior wall of antrum:1. Epithelial dysplasia, low to high gradeโ—‡ Resection margin: - Oral: Free of dysplasia (safety margin: 0.6cm)- Anal: Free of dysplasia (safety margin: 0.6cm) - Greater curvature: Free of dysplasia (safety margin: 0.3cm)- Lesser curvature: Free of dysplasia (safety margin: 0.4cm)์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋กœ ์œ„์™€ ๊ฐ™์ด ๋‚˜์˜ค๋ฉด m์ฝ”๋“œ๋Š” ๋ฌด์—‡์„ ์ค˜์•ผํ• ์ง€์š”?
Stomach์€ high grade dysplasia(/2)๋กœ ์ธ์ •ํ•˜๋Š” ์›๋ฐœ๋ถ€์œ„์ž…๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ M8148/2๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.๋น„๊ณ (bigo)๋ž€์— Bx ๊ฒฐ๊ณผ๋ฅผ ๊ธฐ์žฌํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค. [์ฐธ๊ณ ] ์•”๋“ฑ๋ก์ง€์นจ ๋ณ€๊ฒฝ ๋ฐ ์ฃผ์š”์‚ฌํ•ญ ๊ณต์ง€(2014) - 3.1) High grade dysplasia/neoplasia
์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.Uterus and left adnexa, toatl left hysterectomy and left salpingo-oophorectomy: Minimal - deviation adenocarcinoma, cervix Minimal - deviation adenocarcinoma, cervix์— ๋Œ€ํ•œ ๋ชฐํฌ๋กœ์ง€ ์ฝ”๋“œ๋ฅผ ์ฐพ์„์ˆ˜๊ฐ€ ์—†์–ด์„œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
M8140/3(Adenocarcinoma, NOS)๋กœ ๋ถ€์—ฌํ•ฉ๋‹ˆ๋‹ค.
, M8255/3 ๋ถ„๋ฅ˜์— ๋Œ€ํ•ด ๋ฌธ์˜๋ฅผ ๋“œ๋ฆฝ๋‹ˆ๋‹ค. Lung, right upper lobe, segmentectomy; - Adenocarcinoma, acinar predominant - Histologic components of adenocarcinoma: acinar 90%, lepidic 10%2018 ์•”๋“ฑ๋ก ๊ณต์ง€์‚ฌํ•ญ์— ์˜๊ฑฐํ•˜์—ฌ ํ์•”ํ™˜์ž์˜ Histologic component๋“ค์ด ๋ชจ๋‘ Subtype ๋‚ด์— ์กด์žฌํ•˜๋Š” ๊ฒฝ์šฐ 8255/3์œผ๋กœ ๋ถ„๋ฅ˜ํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค.์ด๋Š” 2012 ์•”๋“ฑ๋ก ์ง€์นจ์„œ 44ํŽ˜์ด์ง€ '๋ณต์žกํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…'์˜ ์šฐ์„ ์ˆœ์œ„ โ‘ ์— ํ•ด๋‹นํ•œ๋‹ค๊ณ  ํŒ๋‹จํ–ˆ์Šต๋‹ˆ๋‹ค.์ด์ „์— ๋‹ค๋ฅธ ์„ ์ƒ๋‹˜๋“ค๊ป˜์„œ ์งˆ์˜๋“ฑ๋ก(2023.08.07.)ํ•˜์‹  ๋‚ด์šฉ์—๋Š” *๋‹จ, ๋น„์ค‘(%)์ด ๋ช…์‹œ๋˜์–ด์žˆ๋Š” ๊ฒฝ์šฐ๋Š” ๋น„์ค‘์ด ํฐ ์กฐ์ง์œผ๋กœ ์ฝ”๋”ฉํ•œ๋‹ค ๋ผ๋Š” ๋ง์ด ์žˆ๋˜๋ฐ ๊ทธ๋Ÿผ ์ € mixed subtype์ฝ”๋“œ๋Š” ๋น„์ค‘์ด ๋ช…์‹œ๊ฐ€ ์—†์„๋•Œ๋งŒ ์ ์šฉ์ด ๊ฐ€๋Šฅํ•˜๋‹ค๋Š” ๊ฑธ๊นŒ์š”? ํ˜น์‹œ ํ•ด๋‹น ๋ ˆํผ๋Ÿฐ์Šค๋Š” ์–ด๋””์„œ ์ฐพ์•„๋ณผ ์ˆ˜ ์žˆ๋‚˜์š”?
ํ•ด๋‹น ์ผ€์ด์Šค๋Š” M8551/3 (Acinar adenocarcinoma of lung(C34._))๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค. ๊ด€๋ จ ๋‚ด์šฉ์€ [์•”๋“ฑ๋ก๊ต์œก์„ผํ„ฐ-์ž๋ฃŒ์‹ค-์•”๋“ฑ๋ก์ž๋ฃŒ-223๋ฒˆ ๊ธ€] "์ค‘๊ธ‰๊ณผ์ •_FAQ" ํŒŒ์ผ ๋‚ด์˜ ํ‘œ๋ฅผ ์ฐธ๊ณ ํ•˜์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
.๋‹ค์ค‘์›๋ฐœ์•”, ์กฐ์งํ•™์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.1. Uterus, total hysterectomy; 1) Neuroendocrine carcinoma (small cell and large cell types), high grade, admixed with early invasive endocervical adenocarcinoma (12), cervix (1-5,9,12,13,19), with (1) tumor size; 3.7x1.5cm (the largest one) (2) depth of stromal invasion; 0.7cm (3) adenocarcinoma in situ (4,6,8-12) (4) squamous cell carcinoma in situ (10,11) (5) clear cervical resection margin (safety margin; 4mm) (3) (6) tumor emboli in lymphovascular spaces (7) no tumor invasion, paracervical soft tissue 2) Leiomyoma with focal dystrophic calcification, intramural type (16) 3) Adenomyosis (14) 4) Late secretory endometrium (14,15)2. Salpinx, both, salpingectomy; 1) Paratubal cyst (17) 2) Unremarkable, both salpinges (17,18) * Number of total LNs (0/7) (F2023-935, F2023-936) (FIGO IB2)์กฐ์ง๋ณ‘๋ฆฌ๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์œ„์™€๊ฐ™์ด ํ™•์ธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.์ด ๊ฒฝ์šฐ 1) C539, M8246/32) C539, M8384/3 ์œผ๋กœ ๋‹ค์ค‘์›๋ฐœ์•” ๋“ฑ๋กํ•ด์•ผํ•˜๋Š”์ง€,C539, M8574/3์œผ๋กœ ํ•œ๋ฒˆ๋งŒ ๋“ฑ๋กํ•˜๋ฉด ๋˜๋Š”์ง€ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค!
M8574/3 Adenocarcinoma admixed with neuroendocrine carcinoma ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.(2012 ์•”๋“ฑ๋ก์ง€์นจ- P.44 ๋ณต์žกํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ๊ทœ์น™- ์กฐํ•ฉ์ฝ”๋“œ ์‚ฌ์šฉ)
์œ ๋ฐฉ์•” SEER ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.DIAGNOSIS: Breast, left, simple mastectomy: MICROINVASIVE CARCINOMA 1) Size of invasive component: <0.1cm (pT1mi) 2) Size of intraductal component: 9.0cm 3) Histologic grade: not applicable 4) Intraductal component: present, intratumoral/extratumoral (99%) (nuclear grade: low, necrosis: present, architectural pattern: papillary/cribriform/solid/comedo, extensive intraductal component: present) 5) Nipple: involvement of lactiferous duct SEER ์ฑ…์„ ์ฐธ๊ณ ํ•˜๋ฉด, " Skin infiltration of primary breast including skin od nipple and/or areloa" ๊ฐ€ SEER2 ์— ํ•ด๋‹นํ•˜๋Š”๋ฐ ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์—์„œ ํ™•์ธ๋œ" 5) Nipple: involvement of lactiferous duct " ์˜ ๋ฌธ๊ตฌ๋ฅผ ํ™•์ธํ•˜์—ฌ SEER 2๋ฅผ ๋ถ€์—ฌํ•ด๋„ ๋˜๋Š”์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.๋ฐ”์˜์‹  ์™€์ค‘์— ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
Skin involvement์˜ ๊ทผ๊ฑฐ๊ฐ€ ์—†์œผ๋ฏ€๋กœ SEER 1 ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.(Confined to breast tissue and fat including nipple and/or areola Paget disease WITH or WITHOUT underlyning tumor)
. Nasal cavity, right(frozen #1 and #1), endoscopic sinus surgery; HPV-associated multiphenotypic sinonasal carcinoma (see note)Nasal cavity, "uncinate process", right(#2), endoscopic sinus surgery; HPV-associated multiphenotypic sinonasal carcinoma (see note)"HPV-associated multiphenotypic sinonasal carcinoma"์— ๋Œ€ํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
M8010/3(Carcioma, NOS)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋กœ Conjunctival squamous intraepithelial neoplasia 2 (squamous epithelial dysplasia, moderate) ์ฒ˜๋Ÿผ ๋‚˜์™”์Šต๋‹ˆ๋‹ค. M์ฝ”๋“œ,seer ์€ ์–ด๋–ป๊ฒŒ ์ค˜์•ผํ• ์ง€ ๋ฌธ์˜ ๋‚จ๊น๋‹ˆ๋‹ค.
์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์—์„œ '2' ์˜ ์˜๋ฏธ๊ฐ€ grade II ๊ฐ€ ๋งž๋Š”์ง€ ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค. ๋งž๋‹ค๋ฉด ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์€ M8077/2 (Squamous intraepithelial neoplasia, grade) ๋กœ ๋ถ€์—ฌํ•ฉ๋‹ˆ๋‹ค. ์ด๋•Œ SEER ์ฝ”๋“œ๋Š” 0 ์ž…๋‹ˆ๋‹ค.* ์•”๋“ฑ๋ก๊ต์œก์„ผํ„ฐ - ์†Œ์†๊ธฐ๊ด€ ์—…๋ฐ์ดํŠธ ํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
1. ์กฐ์ง์€ [DIAGNOSIS] Bile duct, "hilar portion", endoscopic retrograde cholangiopancreatography: Atypical glands, favor ADENOCARCINOMA. ๊ฐ€ ๋‚˜์™”๊ณ  ์ฃผ์น˜์˜๋Š” ์ตœ์ข…์ง„๋‹จ Cholangiocarcinoma ๋กœ ์ง„๋‹จํ•œ ๊ฒฝ์šฐ ์ž…๋‹ˆ๋‹ค. -> M8162/3 ๋ถ€์—ฌ ์—ฌ๋ถ€ ํ™•์ธ2. ์กฐ์ง [DIAGNOSIS] Common hepatic duct, endoscopic retrograde cholangiopancreatography: ADENOCARCINOMA, POORLY DIFFERENTIATED WITH SIGNET-RING CELL COMPONENT ์ด๋ฉฐ ์ฃผ์น˜์˜ ์ตœ์ข…์ง„๋‹จ์€ Hilar cholangiocarcinoma ์ž…๋‹ˆ๋‹ค.๋‚˜์™”๊ณ  ์ฃผ์น˜์˜๋Š” ์ตœ์ข…์ง„๋‹จ hilar Cholangiocarcinoma๋กœ ์ง„๋‹จํ•œ ๊ฒฝ์šฐ ์ž…๋‹ˆ๋‹ค.-> M8162/3 ๋ถ€์—ฌ ์—ฌ๋ถ€ ํ™•์ธ<<์ตœ๊ทผ 23.1์›”๋‹ต๋ณ€์— hilar Cholangiocarcinoma ๊ฐ€ Klatskin tumor์œผ๋กœ ์ง„๋‹จ๋œ๊ฒŒ ์•„๋‹Œ๊ฒฝ์šฐ๋Š” M8160/3 ์œผ๋กœ ํ•˜๋ผ๋Š” ๋‚ด์šฉ ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์— ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ bile duct adenocarcinoma๊ฐ€ ๊ณง cholangiocarcinoma์ž…๋‹ˆ๋‹ค.์ž„์ƒ์˜์˜ ์ตœ์ข…์ง„๋‹จ์ด Klatskin tumor๋กœ ๋‚˜์˜จ๊ฒŒ ์•„๋‹ˆ๋ผ๋ฉด C24.0, M8160/3์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.2021.12.16 ๋‹ต๋ณ€duct์— ์ƒ๊ธด adenocarcinoma๊ฐ€ ๊ณง cholangiocarcinoma์ž…๋‹ˆ๋‹ค. ๊ทธ๊ฒŒ hilar์— ์ƒ๊ฒผ๋‹ค๋ฉด hilar cholangiocarcinoma์ธ ๊ฒƒ์ž…๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ M8162/3์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.>>
์ž„์ƒ์˜์˜ ์ตœ์ข…์ง„๋‹จ์ด Klatskin tumor๋กœ ํ™•์ธ๋˜์ง€ ์•Š์•˜์œผ๋ฏ€๋กœ 1, 2๋ฒˆ ๋ชจ๋‘ M8160/3(Cholangiocarcinoma)๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
ํ™˜์ž ํƒ€๋ณ‘์› FNA ๊ฒฐ๊ณผ Papillary carcinoma ์†Œ๊ฒฌ์œผ๋กœ ๋‚ด์›ํ•˜์—ฌ total thyroidectomy ์‹œํ–‰ํ•˜์…จ์Šต๋‹ˆ๋‹ค.์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์ด ๋‚˜์™€ ์กฐ์งํ•™์  ์ฝ”๋“œ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.Diagnosis :thyroid total thtroidectomy:CarcinomaProbably Differentid high grade thyroid carcinoma (DHGTC) TNM :pT16(m),pN0
M8010/3 (Carcinoma, NOS) ์œผ๋กœ ๋ถ€์—ฌํ•ฉ๋‹ˆ๋‹ค.
Soft tissue, upper scapular, biopsy ๊ฒฐ๊ณผ Neurogenic tumor with uncertain malignant potential (see note).๋กœ ํ™•์ธ๋ฉ๋‹ˆ๋‹ค. note ๋‚ด์šฉ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์œผ๋ฉฐ, ์ดํ›„ ์ถ”๊ฐ€์ ์ธ ์ ˆ์ œ์ˆ ์€ ์‹œํ–‰ํ•˜์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค. Note) The histomorphology and diffuse S-100-positivity favor schwannoma with ancient change. However, due to the multifocal loss of INI-1, the possibility of low grade malignant peripheral nerve sheath tumor cannot be completely excluded. Complete excision with safety margin is recommended. ์œ„์˜ ์กฐ์งํ•™์  ์†Œ๊ฒฌ์ด ์•…์„ฑ์ธ์ง€ ์–‘์„ฑ์ธ์ง€ ๋˜๋Š” ๊ฒฝ๊ณ„์„ฑ์ธ์ง€ ๊ถ๊ธˆํ•˜๋ฉฐ, ํ•ด๋‹น๋˜๋Š” M์ฝ”๋“œ๋Š” ๋ฌด์—‡์œผ๋กœ ๋ถ€์—ฌํ•ด์•ผํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค. ์งˆ๋ณ‘๋ถ„๋ฅ˜์— ๊ด€ํ•ด์„œ๋Š” ๋Œ€ํ•œ๋ณด๊ฑด์˜๋ฃŒ์ •๋ณด๊ด€๋ฆฌ์‚ฌํ˜‘ํšŒ์˜ ์ฝ”๋”ฉํด๋ฆฌ๋‹‰์— ๋ฌธ์˜ํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
, NF1(Neurofibromatosis)๊ฐ€ ์žˆ๋Š” ํ™˜์•„์ด๋ฉฐ, ์˜์‚ฌ์ง„๋‹จ NF1๊ณผ Optic pathway glioma๋ฅผ ์ง„๋‹จํ•˜์˜€์Šต๋‹ˆ๋‹ค.[ MR,Whole body neurofibromatosis (PED)(with enhance) ]1. Newly appeared thickening, signal change, with hyperenhancement in both intraorbital and intracanalicular segments (left > right). --> Suggestive of optic pathway glioma.2. Evident FASIs in the cerebellum, pons, bilateral thalami and basal ganglia, suspiciously in both hippocampi."[MR,Orbit (with enhance) ]1. No change of thickening in both intraorbital segment (left > right).Less prominent enhancement in left optic nerve. - remained subtle enhancement in the proximal intraortibal segment (#18-11) and intracanalicular segment (#18-17) - more prominent enhancement in the right intraorbital segment. --> Suggestive of optic pathway glioma. "Optic pathway glioma์— ๋Œ€ํ•ด C72.3์„ ๋ถ€์—ฌํ•˜๊ณ  ์•”๋“ฑ๋ก๋Œ€์ƒ์— ํ•ด๋‹นํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฌ๊ณ ์ž ํ•ฉ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
"Suggest of~" ๋Š” ์ฃผ์น˜์˜์™€ ํ˜‘์˜ํ•˜์—ฌ ์•”์œผ๋กœ ์ง„๋‹จ๋œ ๊ฒฝ์šฐ์—๋งŒ ์•”๋“ฑ๋ก์ด ๊ฐ€๋Šฅํ•œ ์šฉ์–ด์ž…๋‹ˆ๋‹ค. ์ฃผ์น˜์˜์—๊ฒŒ glioma ํ™•์ง„ ์—ฌ๋ถ€๋ฅผ ํ™•์ธํ•˜์‹  ํ›„ ๋งž๋‹ค๋ฉด ์•”๋“ฑ๋ก(C72.3 , M9380/3)ํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
๊ฐ„์•” ์น˜๋ฃŒ์ค‘ cryotherapy(cryoablation)์„ ์‹œํ–‰ํ•˜๋Š” ๊ฒฝ์šฐ๊ฐ€ ์žˆ์Šต๋‹ˆ๋‹ค.[ ๊ฒ€์‚ฌ์ผ: 2023.05.30 - ๊ฒฐ๊ณผํ™•์ •์ผ: 2023.05.30 - US,Liver cancer RFA planning ]US,Liver cancer RFA planning *Findings: S8์— HCC๋กœ ์ƒ๊ฐ๋˜์—ˆ๋˜ ๋ณ‘๋ณ€์€ ํ˜„์žฌ ์ดˆ์ŒํŒŒ์ƒ ๋šœ๋ ทํ•˜๊ฒŒ ๋ณด์ด์ง€ ์•Š์•„ US-guided procedure ์–ด๋ ค์šธ ๊ฒƒ์œผ๋กœ ์ƒ๊ฐ๋จ. S5/S6์— dysplastic nodule with HCC foci๋กœ ์ƒ๊ฐ๋˜์—ˆ๋˜ ๋ณ‘๋ณ€์€ ๊ฒฝ๊ณ„๊ฐ€ ๋ถˆ๋ถ„๋ช…ํ•œ ์•ฝ 2.2 cm ํฌ๊ธฐ์˜ ๋ณ‘๋ณ€์œผ๋กœ ๋ณด์ด๊ณ  ์žˆ์Œ. ์ด ๋ณ‘๋ณ€์— ๋Œ€ํ•ด์„œ cryoablation ์‹œํ–‰ํ•  ์˜ˆ์ •์ž„.[ ๊ฒฐ ๋ก  ]US-guided cryoablation is feasible for HCC in S5/6."[ ๊ฒ€์‚ฌ์ผ: 2023.05.30 - ๊ฒฐ๊ณผํ™•์ •์ผ: 2023.05.30 - US,Liver cancer cryoablation ]US,Liver cancer cryoablation *Liver right lobe central portion์— ์žฅ๊ฒฝ ์•ฝ 2.2 cm ํฌ๊ธฐ์˜ ill-defined mass์— ๋Œ€ํ•ด์„œ ice rod 3๊ฐœ๋ฅผ ์ด์šฉํ•ด์„œ cryoablation ์‹œํ–‰ํ•˜์˜€์Œ[ ๊ฒฐ ๋ก  ]US-guided cryotherapy was done. ์ด์™€ ๊ฐ™์ด ์ดˆ์ŒํŒŒ, CT ์œ ๋„ํ•˜ ๊ฐ„๋ƒ‰๋™์ œ๊ฑฐ์ˆ ์„ ์‹œํ–‰ํ•˜๋Š” ๊ฒฝ์šฐ ์น˜๋ฃŒ๋ฐฉ๋ฒ• '์ˆ˜์ˆ '์— ํ•ด๋‹นํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋ณด๋ฉด ๋ ์ง€ '๊ธฐํƒ€'์— ํ•ด๋‹นํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค
๊ธฐํƒ€์น˜๋ฃŒ๋กœ ๋“ฑ๋กํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.(์น˜๋ฃŒ๋ช… cryotherapy(cryoablation) ํ•จ๊ป˜ ๊ธฐ์žฌ)
์œ ๋ฐฉ์•” ํ˜•ํƒœํ•™ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.DIAGNOSIS:Breast, left, lumpectomy:MIXED INVASIVE DUCTAL CARCINOMA AND INVASIVE PAPILLARY CARCINOMA1) Size of tumor: 3.5cm (pT2)2) Intraductal component: present, intratumoral/extratumoral (20%)===============================================ํ•ด๋‹น case์˜ ๊ฒฝ์šฐ, ์•„๋ž˜ M์ฝ”๋“œ ์ค‘ ์–ด๋–ค ํ˜•ํƒœํ•™์„ ๋ถ€์—ฌํ•˜๋ฉด ๋ ์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค1) 8500/3 : Infiltrating duct carcinoma NOS2) 8503/3 : Intraductal papillary adenocarcinoma with invasion
M8523/3 (Infiltrating duct mixed with other types of carcinoma(C50._)) ์œผ๋กœ ๋ถ€์—ฌํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
์ฃผํ˜ธ์†Œ :Intraaxial brain tumor, C/W high-grade glioma์ˆ˜์ˆ ๋ช… : tumor partial removal [FROZEN SECTION PERMANENT DIAGNOSIS] Brain, right, temporal lobe, biopsy; Consitent with high-grade glioma [DIAGNOSIS] Brain, tumor removal; High-grade glial tumor -----------------------------------------------------------------1. C719 M9380/3 ์œผ๋กœ ์ฝ”๋”ฉํ•˜์˜€๋Š”๋ฐ high-grade glial tumor๋ฅผ Glioma๋กœ ๋ณด๋Š” ์ด์œ ๊ฐ€ ์žˆ๋Š”์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.2. glial tumor๋ฅผ glioblastoma ๋กœ ๋ณด๋Š” ๊ฒฝ์šฐ๋Š” ์–ด๋–ค๊ฒฝ์šฐ์ธ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.
์ž„์ƒ ์ง„๋‹จ์— ๊ด€ํ•œ ๋‚ด์šฉ์ด๋ฏ€๋กœ ์ฃผ์น˜์˜์—๊ฒŒ ์งˆ๋ฌธํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
, ์•”๋“ฑ๋ก ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.Skin, abdomen, excision; 1. Atypical spitzoid tumor, junctional, residual (SEE NOTE) with 1) post excisional biopsy status (S23-19832) 2) tumor extent: epidermis and papillary dermis 3) tumor thickness: 0.5mm 4) tumor infiltrating lymphocytes: not identified 5) mitoses: <1/1ใŽŸ 6) regression: not identified 7) microscopic satellite: not identified 8) perineural infiltration: not identified 9) lymphovascular invasion: not identified 10) ulceration: not identified 11) resection margin: free resection margin - safety margins: 12 o'clock: 3.2mm 3 o'clock: 4.8mm 6 o'clock: 2.4mm 9 o'clock: 9.4mm deep: 6.0mm 2. Biopsy site changesNote)1. Previous slide (S23-19832) was reviewed.2. Close-term follow-up is recommended.3. CGH๋ฅผ ํ†ตํ•œ copy number variation, FiSH test๋กœ ์—ฌ๋Ÿฌ๊ฐ€์ง€ gene fusion ์—ฌ๋ถ€๋ฅผ ํ™•์ธํ•ด์•ผ ์ •ํ™•ํ•œ ์ง„๋‹จ์ด ๊ฐ€๋Šฅํ•˜๋‚˜ ์šฐ๋ฆฌ๋‚˜๋ผ์—์„œ๋Š” ๋ณ‘๋ฆฌ์ง„๋‹จ์— ํ™œ์šฉํ•˜๋„๋ก ํ—ˆ๊ฐ€๋ฐ›์ง€ ๋ชปํ•˜์˜€์Šต๋‹ˆ๋‹ค.'Atypical spitzoid tumor, junctional'์˜ M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M8770/0 Spitz nevus, atypical(C44._) ์œผ๋กœ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.[WHO Classification of Skin Tumours(2018) P.111 ์ฐธ๊ณ ]
~์†Œํ™”๊ธฐ์—์„œ Colonoscopic Mucosal and Submucosal Resection ์‹œ์ˆ ํ•˜์‹  ๋ถ„์ธ๋ฐ, ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ๋ฅผ ๋ณด๋‹ˆ M์ฝ”๋“œ๋ฅผ ์–ด๋–ป๊ฒŒ ์ค˜์•ผํ• ์ง€ ๋ชจ๋ฅด๊ฒ ์–ด์„œ ์งˆ๋ฌธ๋“œ๋ฆฝ๋‹ˆ๋‹ค.ใ€ํŒ๋…๊ฒฐ๊ณผใ€‘Specimen: 1 group A piece of grayish-tan polypoid mass, measuring 1.1 x 0.7 x 0.4 cm in size Entirely blocked in A. DIAGNOSIS :Cecum, colonoscopic mucosal resection: A well-circumscribed submucosal lesion composed of cystically dilated atypical oncocytic glands in a rich lymphoid stroma, favor GALT/dome-type carcinoma, well-differentiated, 0.2 cm in greatest dimension, with 1) overlying high-grade dysplastic adenomatous component, 1.1 x 0.7 cm in size 2) confinement to submucosa (1.5 mm in thickness) 3) lymphovascular invasion: not identified 4) perineural invasion: not identified 5) indeterminate resection margin 6) pT1 by AJCC 8th edition (See note) note) The overall microscopic findings favor a GALT/dome-type carcinoma. It is thought that the tumors represent early low-grade lesions limited to the submucosa (pT1). Recurrences or metastases to lymph nodes or distant sites have not been reported for any patients with this tumor, and, thus it seems resonable to conclude that adequate local excision is sufficient treatment (Chetty R et al. World J Gastrointest Oncol 2019 15;11:59-70).*Immunohistochemical staining result p53: positive, diffuseํ˜„์žฌ ์•”๊ณผ ๊ด€๋ จํ•œ ๋‹ค๋ฅธ ์˜์ƒํ•™์  ๊ฒ€์‚ฌ๋Š” ์‹œํ–‰ํ•˜์ง€ ์•Š์•˜์Šต๋‹ˆ๋‹ค.BX ๊ด€๋ จํ•ด์„œ ์ž๋ฃŒ๋ฅผ ์ฐพ์•„๋ณด๋‹ˆ ๊ต‰์žฅํžˆ ๋“œ๋ฌธ ์ผ€์ด์Šค ๊ฐ™์Šต๋‹ˆ๋‹ค.. ๊ต์ˆ˜๋‹˜๊ป˜์„œ ์•…์„ฑ์€ ๋งž๋‹ค๊ณ  ํ•˜์…จ๋Š”๋ฐ, ์ ํ•ฉํ•œ M์ฝ”๋“œ๊ฐ€ ๋ฌด์—‡์ธ์ง€ ์•Œ๋ ค์ฃผ์‹œ๋ฉด ๊ฐ์‚ฌํ•˜๊ฒ ์Šต๋‹ˆ๋‹ค~
๋ณ‘๋ฆฌ์ž๋ฌธ ๊ฒฐ๊ณผ ํ•ด๋‹น ์ง„๋‹จ๋ช…์€ ๋งค์šด ๋“œ๋ฌธ variant of adenocarcinoma ์˜ ์ฆ๋ก€๋กœ์„œ ๋ถ€์—ฌ ๊ฐ€๋Šฅํ•œ ์„ธ๋ถ€ ์ฝ”๋“œ๊ฐ€ ์—†์œผ๋ฏ€๋กœ M8140/3(Adenocarcinoma, NOS) ๋กœ ์ฝ”๋”ฉํ•ด์ฃผ์‹œ๊ธฐ๋ฐ”๋ž๋‹ˆ๋‹ค.
[DIAGNOSIS]Breast, right, simple mastectomy with sentinel lymph node biopsy:- INVASIVE DUCTAL CARCINOMA WITH MICROPAPILLARY COMPONENTS (1.5X1.2X1.2 CM)ARISING IN ENCAPSULATED PAPILLARY CARCINOMA (TOTAL SIZE: 2.2X1.5X1.2 CM),NUCLEAR GRADE 2/3, HISTOLOGIC GRADE 2/31) intraductal component (40 %)/ EIC (+)2) lymphatic invasion: not identified3) venous invasion: not identified4) perineural invasion: not identified5) growth pattern: infiltrative6) calcification: absent7) skin invasion: absent8) nipple invasion: absent9) resected margin: not involved10) associated findings: unremarkable11) other findings: unremarkable์‚ฌ์ด์ฆˆ๊ฐ€ ํฐ Invasive micropapillary carcinoma of breast M8507/3์•„๋‹ˆ๋ฉด morphology ์ˆซ์ž๊ฐ€ ํฐ Encapsulated papillary carcinoma with invasion M8504/3์•„๋‹ˆ๋ฉด Infiltrating duct mixed with other types of carcinoma M8523/3 ์–ด๋–ค๊ฑธ ๋ถ€์—ฌํ•˜๋Š”๊ฒŒ ๋งž์„๊นŒ์š”?
์•…์„ฑ์•”์ธ M8507/3(micropapillary carcinoma of breast)์œผ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
๋‡Œ์ˆ˜์ˆ  ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์ด ๋‚˜์™”์Šต๋‹ˆ๋‹ค๋ณ‘๋ฆฌ๊ฒฐ๊ณผBrain, craniotomy for excisionA. Labeled as tumor #1 : HIGH-GRADE ROUND CELL UNDIFFERENTIATED SARCOMA, see NOTEB. Labeled as tumor #2 : HIGH-GRADE ROUND CELL UNDIFFERENTIATED SARCOMA. see NOTEC. Labeled as tumor core: HIGH-GRADE ROUND CELL UNDIFFERENTIATED SARCOMA, see NOTE 1. The results of immunohistochemical stainGAP : NegativeOlig2 : NegativeDH-1 : NegativeATPX : No Loss53 : POSITIVE (30%-40%)Synaptophysin : NegativeH3K27me3: EquivocalMyoD1 : NegativeCD99 : POSITIVE WT-1 : POSITIYEKi-67 (Proliferative index) : 30%2.2. CiC-rearranged sarcona, CNS WHO grade 4 ์˜ ๊ฐ€๋Šฅ์„ฑ์ด ์žˆ์Šต๋‹ˆ๋‹ค.ํ™•์ง„์„ ์œ„ํ•ด cIC gene fusi on ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค์ƒ‰์ธ๋ถ„๋ฅ˜์ƒSarcoma์ด์ง€๋งŒ connective tissure์•ˆ์— brain์€ ์—†์œผ๋ฏ€๋กœ ํ•ด๋‹น๋ถ€์œ„์ธ C71.๋Œ€๋กœ ๋ถ„๋ฅ˜ํ•˜๋ฉด ๋˜๋Š”๊ฒƒ์ธ์ง€,C49-๋Œ€๋กœ ๋ถ„๋ฅ˜ํ•ด์•ผํ•˜๋Š”๊ฒƒ์ธ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.์‹ ๊ฒฝ์™ธ๊ณผ์—์„œ๋Š” c71๋กœ ์ง„๋‹จ์„ ์ค€ ์ƒํƒœ์ด๊ณ ํ•ญ์•”์œ„ํ•ด ์ž…์›ํ•œ ํ˜ˆ์•ก์ข…์–‘๋‚ด๊ณผ์—์„  c49์ฝ”๋“œ๊ฐ€ ํ•„์š”ํ•œ ์ƒํ™ฉ์ž…๋‹ˆ๋‹ค.์•”๋“ฑ๋ก์‹œ ์›๋ฐœ์•”์€ ์–ด๋””๋กœ ํ•˜๋Š”๊ฒƒ์ด ๋งž๋Š”์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.
ํ•ด๋‹น ์ •๋ณด๋งŒ์œผ๋กœ๋Š” ์›๋ฐœ๋ถ€์œ„ ํ™•์ธ์ด ์–ด๋ ต์Šต๋‹ˆ๋‹ค. see note ๋˜๋Š” ๋‹ค๋ฅธ ์˜์ƒ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๋„ ์ฐธ๊ณ ํ•˜์‹œ์–ด ์ฃผ์น˜์˜๋กœ๋ถ€ํ„ฐ ์›๋ฐœ๋ถ€์œ„ ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.
Colon, terminal ileum, appendix, right hemicolectomy: Undifferentiated carcinoma with rhabdoid feature -> 1) M8020/3 Carcinoma, Undifferentiated NOS 2) M8963/3 Rhabdoid tumor NOS ์ด ๊ฒฝ์šฐ M Code ๋ฐ M8963/3 ์ผ ๊ฒฝ์šฐ์—๋„ ๋ถ„ํ™”๋„๊ฐ€ 4(Undifferentiated)์ธ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M8020/3(Carcinoma, undifferentiated, NOS), ๋ถ„ํ™”๋„ '4' ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
Left thyroid, thyroidectomy: BRAF pcr ํ™•์ธํ›„ ํ™•์ง„ ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.A)B) 1. NON-INVASIVE FOLLICULAR NEOPLASM WITH PAPILLARY LIKE NUCLEAR FEATURES. - with 1) Tumor location: Left 2) Tumor size: 2.5x1.6cm (pT2). 3) Surgical resection margins: Negative for malignancy. 4) Lymphovascular invasion is not identifed. 5) Regional lymph nodes: No metastasis out of lymph nodes. (Total No.: 0/2, B: 0/2) 6) Other pathology: None. 7) Parathyroid gland: Present. โ–  Pathologic stage: pT2N0CK19, Galectin 3: focal positiveHMW-CK; negativeBRAF: negative์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ์ƒ M8349/1 ์œ ๋‘์ƒ ์œ ์‚ฌ ํ•ต ํŠน์ง•์„ ๋™๋ฐ˜ํ•œ ๋น„์นจ๋ฒ”์„ฑ ์†Œํฌ์„ฑ ๊ฐ‘์ƒ์„  ์‹ ์ƒ๋ฌผ๋กœ ํ™•์ธ ๋˜์—ˆ์œผ๋‚˜ ์ž„์ƒ์˜์™€ ๋ณ‘๋ฆฌ์˜๋Š” ์•…์„ฑ์œผ๋กœ ๋ณธ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. ์œ„์™€ ๊ฐ™์€ ๊ฒฝ์šฐ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ๋˜๋Š”์ง€์™€ ์ƒ๋ณ‘์ฝ”๋“œ C739 ํ˜•ํƒœํ•™์  ์ฝ”๋“œ๋Š” ์–ด๋–ป๊ฒŒ ์ž…๋ ฅํ•ด์•ผ ํ•˜๋Š”์ง€์— ๋Œ€ํ•ด ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
์œ ์„ ํ†ตํ™”ํ–ˆ์Šต๋‹ˆ๋‹ค.
์ˆ˜๊ณ  ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค. lymphoma ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ณจ์ˆ˜๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์•„๋ž˜๋กœ ํ™•์ธ๋˜๋ฉฐ, M9673/3Mantle cell lymphoma(includes all variants)์ด ๋งž๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. CLINICAL INFORMATIONFever of unknown originPERIPHERAL BLOOD FINDINGSHb 9.3g/dL WBC 18.85x10ยณ/ฮผL PLT 370X10ยณ/ฮผL Reticulocyte 2.64%RBC: Normocytic normochromic anemia PolychromasiaWBC: Slightly increased in number Atypical lymphoid cells 19% Left-shifted maturationPLT: Normal in numberBONE MARROW FINDINGSDIFFERENTIAL COUNT (Total count: 500) M : E ratio 1.8 : 1Myeloblasts 0.4% Monoblasts 0% Promyelocytes 0% Promonocytes 0% Myelocytes 8% Monocytes 0.4% Metamyelocytes 12.4% Immature monocytes 0% Band neutrophils 10% Eosinophils 1% Segmented neutrophils 4% Basophils 0% Pronormoblasts 0.4% Plasma cells 2.2% Basophilic normoblasts 2% Histiocytes 1% Polychromatophilic normoblasts 10.4% Mast cells 0% Orthochromic normoblasts 7.6% Metastatic cells 0% Lymphoblasts 0% Immature cells 0% Atypical lymphoid cells 34.2% Lymphocytes 6% BM ASPIRATION (LEFT)The bone marrow aspirate shows good quality.The estimated M:E ratio is 1.8:1.Atypical lmyphoid cells are counted up to 34.2% of total nucleated cells.Erythropoietic cells are observed.Granulopoietic cells are obesrved.Megakaryocytes are frequently observed.Iron stain: normal storage iron (Grade 2+/6)BM BIOPSY (LEFT)The biopsy section is good quality.The cellularity is 20%-30% which is normocellular for age.Atypical lymphoid aggregates are scattered.Erythropoiesis is observed.Granulopoiesis is observed.Megakaryocytes are increased in number (8-12/HPF).Plasma cells and eosinophils are unremarkable.Fibrosis are not present.Immunohistochemical StainCD34: not increasedCD117: not increasedCD61: increased in numberCD3: normal distributionCD5: positive on increased atypical lymphoid cells (interstitial)CD10: normal distributionCD20: positive on increased atypical lymphoid cells (interstitial)CD23: normal distributionCyclin D1: weak positive on some atypical lymphoid cellsMPO: normal distributionRelated StudyLeukemia/Lymphoma immunophenotyping: Leukemic manifestation of CD5 positive lymphomaChromosome study: PendingIGH/CCND1 rearrangement FISH: Negative (0/500 : 0%)IGH/CCND1 atypical signal FISH: Positive (56/500 : 11.2%)Specimen Quality (1: Good, 2: Acceptable, 3: Poor)BM23-0058 Aspirate : 1 Biopsy : 1CONCLUSION ========================================Normocellular Marrow with Interstitial Infiltration of Lymphoid AggregatesBone Marrow Involvement of CD5-positive Mature B-cell Neoplasm (Suggestive of Leukemic Non-Nodal Mantle Cell Lymphoma)
''suggestive' ์šฉ์–ด๋Š” ์˜์‚ฌ์— ํŒ๋‹จ์— ๋”ฐ๋ผ ๋‹ค๋ฅด๊ฒŒ ์‚ฌ์šฉ๋˜๋ฏ€๋กœ ์ตœ์ข…์ ์œผ๋กœ Mantle zone lymphoma ์ง„๋‹จ์ด ๋งž๋‹ค๋ฉด M9673/3๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
๋‹ค์Œ ํŒŒ์ผ์„ ์ฐธ์กฐ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.tongue ์—์„œ ๋‚˜์˜จ high grade dysplasia ์˜ ๊ฒฝ์šฐ ๋ฌด์—‡์œผ๋กœ ๋ถ€์—ฌํ•ด์•ผํ• ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค. ํ•ด๋‹น ํŒŒ์ผ์ž๋ฃŒ์—๋Š” neopalsm of uncertain behavior of tongue ์œผ๋กœ ๊ฒฝ๊ณ„์„ฑ์œผ๋กœ ์ง„๋‹จ๋˜์–ด ์žˆ๋Š”๋ฐ ์•”๋“ฑ๋ก ์ง€์นจ์ƒ tongue์—์„œ ๋‚˜์˜จ high grade dysplasia๊ฐ€ ๊ฒฝ๊ณ„์„ฑ์ด๋ผ๋Š” ๊ทผ๊ฑฐ๋ฅผ ์ฐพ์„ ์ˆ˜ ์—†์–ด์„œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋˜ํ•œ, high grade dysplasia๋ฅผ /2๋กœ ์ธ์ •ํ•˜๋Š” ์›๋ฐœ๋ถ€์œ„์—๋„ ํ•ด๋‹นํ•˜์ง€ ์•Š์•„ ์ œ์ž๋ฆฌ์•”์œผ๋กœ๋„ ๋“ฑ๋กํ•  ์ˆ˜ ์—†์„๊ฑฐ ๊ฐ™์€๋ฐ ๊ฒฝ๊ณ„์„ฑ์œผ๋กœ ๋ณผ์ˆ˜ ์žˆ๋Š” ๊ทผ๊ฑฐ๊ฐ€ ์žˆ์„๊นŒ์š”?
'High grade dysplasia์˜ ํ–‰ํƒœ์ฝ”๋“œ๋ฅผ /2๋กœ ์ธ์ •ํ•˜๋Š” ์›๋ฐœ๋ถ€์œ„์— tongue๋Š” ์ œ์‹œ ๋˜์–ด ์žˆ์ง€ ์•Š์Šต๋‹ˆ๋‹ค. ์ฃผ์น˜์˜์™€ ์ƒ์˜ ํ›„ ๊ฒฐ์ •ํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค.[์•”๋“ฑ๋ก ์ง€์นจ ๋ณ€๊ฒฝ ๋ฐ ์ฃผ์š”์‚ฌํ•ญ ๊ณต์ง€ (2014) , 1) High grade dysplasia / neoplasia ๋‚ด์šฉ์ฐธ๊ณ ]Neoplasm of uncertain behavior of tongue(see comment) ๋ผ๋ฉด ์•”๋“ฑ๋ก๋Œ€์ƒ ์•„๋‹™๋‹ˆ๋‹ค.
1. M์ฝ”๋“œ ๋ฌธ์˜Mastectomy,Invasive carcinoma with mixed papillary, mucinous and micropapillary-like features.2. SEER ๋ฌธ์˜์›๋ฐœ๋ถ€์œ„: C718(Lt)MRI: infiltrating astrocytoma๊ฐ€ Rt frontoparietal lobe์— meta ๋จ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
1) M8523/3(Infiltrating duct mixed with other types of carcinoma)์œผ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค. 2) SEERCODE '5(Regional) ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
stomach ์— ESD ํ•œ ๊ฒฐ๊ณผ Tubular adenocarcinoma, well differentiated, intramucosal, associated with tubular adenoma with high grade dyspalsia (pT1aNxMx)ํŒ๋…๋˜์—ˆ๋Š”๋ฐ /3(malignant) ๋กœ ๋“ฑ๋กํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€ /2(in situ) ๋กœ ๋“ฑ๋กํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.-------------------------------------Stomach, prepyloric, ESD; Tubular adenocarcinoma, well differentiated, intramucosal, associated with tubular adenoma with high grade dyspalsia (pT1aNxMx)1) Location: prepyloric.2) Size: 0.15 cm.3) Histologic type and differentiation : Tubular adenocarcinoma, well differentiated4) Depth of the lesion: intramucosal(0.08 cm.) (pT1a)5) Lymphovascular invasion : not identified6) Resected margin; a) Lateral margin; free of dysplastic lesion b) Lesion free zone: Oral; 1.2 cm., Anal; 0.7 cm., Posterior side; 0.8 cm., Lesser curvature side; 0.8 cm.c) Deep margin; free of dysplastic changesB. Non-dyslastic gastric mucosa; Chronic superificial gastritis
M8211/3(Tubular adenocarcinoma)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์ง„๋‹จ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. dermatofibrosarcoma ํ”ผ๋ถ€์„ฌ์œ ์œก์ข…์€ ์ง„ํ”ผ ๋ฐ ํ”ผํ•˜ ์—ฐ๋ถ€์กฐ์ง์— ๋ฐœ์ƒํ•˜๋Š” ํ”ผ๋ถ€์˜ ์•…์„ฑ์ข…์–‘์œผ๋กœ C44._๋กœ ๋ถ„๋ฅ˜ํ•˜๋Š” ๊ฒƒ์ด ๋งž์œผ๋‚˜ 1. ์‹ค์ œ ์›๋ฐœ ๋ถ€์œ„์˜ ์•…์„ฑ์ข…์–‘์ด ์—ฐ์กฐ์ง๊ณผ ๊ทผ๋ง‰์—์„œ๋„ ๋ฐœ๊ฒฌ๋œ ๊ฒฝ์šฐ C44 ํ”ผ๋ถ€๊ฐ€ ์•„๋‹Œ C49 ๊ฒฐํ•ฉ์กฐ์ง ๋ฐ ์—ฐ์กฐ์ง์˜ ์•…์„ฑ์‹ ์ƒ๋ฌผ๋กœ ๋ถ„๋ฅ˜๊ฐ€ ๊ฐ€๋Šฅํ•œ์ง€ 2. Skin์—์„œ ์‹œ์ž‘๋˜์–ด Soft tissue๊นŒ์ง€ ์นจ์œค๋œ๊ฑฐ๋ผ ๋ณด๋Š”๊ฒฝ์šฐ๋Š” C44 ํ”ผ๋ถ€์˜ ์•…์„ฑ์ข…์–‘์ด ๋งž๋Š” ๊ฒƒ์ธ์ง€ 3. C49๋กœ ๋ถ„๋ฅ˜ํ• ์ˆ˜ ์žˆ๋Š” ๊ฒฝ์šฐ๋Š” ์–ด๋–ค ๊ฒฝ์šฐ์ธ์ง€ ์งˆ์˜ ๋‚จ๊น๋‹ˆ๋‹ค.
์‹ค์ œ case๋กœ ๋ฌธ์˜๋ฐ”๋ž๋‹ˆ๋‹ค. ์ค‘์•™์•”๋“ฑ๋ก๋ณธ๋ถ€๋Š” ์‹ค์ œ case๋ฅผ ๊ธฐ๋ฐ˜์œผ๋กœ๋งŒ ๋‹ต๋ณ€์„ ๋“œ๋ฆด ์ˆ˜ ์žˆ์Œ์„ ์–‘ํ•ด๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
Large intestine, rectosigmoid, laparoscopy assisted low anterior resection;CARCINOMA in a tubulovillous adenoma.ADENOCARCINOMA, well differentiated. 1) Location: rectosigmoid junction 2) Gross type: polypoid 3) Size: 5.0x4.5 cm 4) Depth of invasion: invades proper muscle (pT2) 5) Resection margins, proximal and distal: free from carcinoma (safety margin: proximal 4.0 cm, distal 2.0 cm, circumferential 6 mm) 6) Regional lymph node metastasis: no metastasis in all 28 regional lymph nodes (pN0) 7) Lymphatic invasion: not identified 8) Vascular invasion: not identified 9) Perineural invasion: not identified 10) Tumor budding: not identified 11) Stage โ… M8263/3 Adenocarcinoma in tubulovillous adenoma ์œผ๋กœ ์•”๋“ฑ๋กํ•ด๋„ ๋ ๊นŒ์š”?
M8263/3(Adenocarcinoma in tubulovillous adenoma)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
. ๋‚œ์†Œ์•” ํ˜•ํƒœํ•™ ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. Ovary and salpinx, bilateral, salpingo-oophorectomy:Mixed carcinoma, low grade serous carcinoma (70%) and mucinous carcinoma (30%), right ovary์ด ๊ฒฝ์šฐ ์–ด๋–ค ํ˜•ํƒœํ•™ ์ฝ”๋“œ๊ฐ€ ๋งž๋Š”๊ฑด์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. 1. mixed adenoca.2. low grade serous carcinoma3. mucinous carcinomaํ•ญ์ƒ ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋‹ต๋ณ€ ์ˆ˜์ •(2023.10.23) - ์ž๋ฌธ์ค‘์ž…๋‹ˆ๋‹ค.
Common bile duct cancer (C24.0 )์— ๋Œ€ํ•ด ์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋กœ Pancreas: DUCTAL ADENOCARCINOMA, MODERATELY DIFFERENTIATED associated with intraductal papillary mucinous neoplasm โ—‡ Gross type: Infiltrativeโ—‡ Size: 3.2x2.2cm (pT2)โ—‡ Tumor extent: Involvement of pancreas and common bile duct wall ๋กœ ๋‚˜์™”์œผ๋ฉด.. M์ฝ”๋“œ๋Š” ์–ด๋–ค๊ฑธ ์ค˜์•ผํ• ์ง€์š”
๊ด€๋ฆฌ์ž ๋‹ต๋ณ€ ์—†์Œ
2018๋…„ ์•„๋ž˜์™€ ๊ฐ™์€ ๋ณ‘๋ฆฌ๊ฒ€์‚ฌ๋กœ C3411 M8255/3 ์•”๋“ฑ๋ก ๋˜์–ด ์žˆ๋Š” ๋ถ„์ž…๋‹ˆ๋‹ค.Lung, upper lobe, left, VATS lobectomy : ADENOCARCINOMA, MIXED ACINAR AND SOLID PATTERN2023๋…„ 6์›” ๊ธฐ๊ด€์ง€ ๋‚ด์‹œ๊ฒฝ ํ›„ Left hilum ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์ด ๋‚˜์™”์Šต๋‹ˆ๋‹ค.Lung, left, bronchoscopic biopsy : SMALL CELL CARCINOMA์˜๋ฃŒ์ง„์€ 2023๋…„ 6์›” ๋ฐœ๊ฒฌ๋œ ์•”์„ ์žฌ๋ฐœ์ด ์•„๋‹Œ ์›๋ฐœ์•”์œผ๋กœ ํŒ๋‹จํ•œ๋‹ค๊ณ  ํ•˜์˜€์Šต๋‹ˆ๋‹ค.์งˆ๋ฌธ. ์ด ๊ฒฝ์šฐ ๋‹ค์ค‘์›๋ฐœ์•”์œผ๋กœ ๊ฐ๊ฐ ๋“ฑ๋กํ•˜๋ฉด ๋ ์ง€ (C3411 M8255/3 , C3401 M8041/3)์•„๋‹ˆ๋ฉด ์ค‘๋ณต๋ณ‘๋ณ€์•”์ข…(C3481 M8255/3)์œผ๋กœ ๋“ฑ๋กํ•˜๋ฉด ๋ ์ง€ ์งˆ๋ฌธ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋ฐœ์ƒ๋…„๋„๊ฐ€ ๋‹ค๋ฅด๋”๋ผ๋„ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์ด๋ฏ€๋กœ ๋‹ค์ค‘์›๋ฐœ์•”์— ํ•ด๋‹น๋˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. M8255/3๊ณผ 8041/3์€ ๋™์ผ ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์œผ๋กœ 2018๋…„ ์ด๋ฏธ ์•”๋“ฑ๋กํ•˜์˜€์œผ๋ฏ€๋กœ ์ถ”๊ฐ€ ์•”๋“ฑ๋กํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค.
Thecofibroma M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.Thecoma(M8600/0), Fibroma(M8810/0) ์ค‘ ๋†’์€ ์ฝ”๋“œ๋ฅผ ์ฃผ๋ฉด ๋˜๋‚˜์š”?# Ovary and salpinx, left, salpingo-oophorectomy: Thecofibroma, ovary
ํ•ด๋‹น ์ง„๋‹จ๋ช…์€ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
~ ๋‚ด์‹œ๊ฒฝ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์ด ๋‚˜์™”๊ณ Stomach, high body, anterior wall, endoscopic biopsy; 1 & 2: ADENOCARCINOMA, poorly differentiated. ์ดํ›„ ์ˆ˜์ˆ  ํ›„ ๊ฒฐ๊ณผ๊ฐ€ ์•„๋ž˜์™€ ๊ฐ™์ด ๋‚˜์™”์Šต๋‹ˆ๋‹ค.Stomach, total gastrectomy;ADVANCED GASTRIC CARCINOMA.1) Location: upper third, Center at cardia and anterior wall2) Gross type: Borrmann type 23) Histologic type: carcinoma with lymphoid stroma (medullary carcinoma)4) Histologic type by Lauren: diffuse 5) Size: 5.0x4.5x1.3 cm6) Depth of invasion: penetrates serosa (visceral peritoneum) (pT4a)7) Resection margins, proximal and distal: free from carcinoma8) Lymph node metastasis: metastasis to 3 out of 65 regional lymph nodes (pN2)9) Lymphatic invasion: not identified10) Venous invasion: not identified11) Perineural invasion: present ์ด๋•Œ ์›๋ฐœ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
C16.0(Gastric Cardia)๋กœ ์ฝ”๋”ฉํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค. [2012 ์•”๋“ฑ๋ก์ง€์นจ์„œ p33. 3)์ƒ์ถฉ๋˜๋Š” ๋ณด๊ณ ์„œ] ์ฐธ๊ณ 
์ฑ„์ทจ๋ถ€์œ„: 1:L2 IDEM tumor DIAGNOSIS: Spine, L2, biopsy: Paraganglioma ํ™˜์ž๋ถ„ ์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ Paraganglioma ๋‚˜์™”์œผ๋‚˜ ์ฃผ์น˜์˜ ๊ต์ˆ˜๋‹˜์ด ๋ณ‘๋ฆฌ๊ณผ ๊ต์ˆ˜๋‹˜๊ณผ ์ƒ์˜ ํ›„ ์–‘์„ฑ์œผ๋กœ ์†Œ๊ฒฌ ์ฃผ์…จ์Šต๋‹ˆ๋‹ค. ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ์™€ ์ฃผ์น˜์˜ ์ง„๋‹จ์ด ๋‹ค๋ฅผ ๊ฒฝ์šฐ ์ฃผ์น˜์˜ ์ง„๋‹จ์— ๋”ฐ๋ผ ๋“ฑ๋กํ•˜๋ฏ€๋กœ C720 M8680/0์œผ๋กœ ์ƒ๊ฐ๋ฉ๋‹ˆ๋‹ค.paraganglioma๋Š” ICD-O-3 1st ์—์„œ๋Š” /0, /1 ๋ชจ๋‘ ๊ฐ€๋Šฅํ–ˆ์ง€๋งŒICD-O-3 2nd ์—์„œ๋Š” M์ฝ”๋“œ ์ž์ฒด๊ฐ€ ์•…์„ฑ์œผ๋กœ ๋ณ€๊ฒฝ๋œ ๊ฒƒ์œผ๋กœ ์•Œ๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿด ๊ฒฝ์šฐ ์–ด๋–ป๊ฒŒ ์•”๋“ฑ๋ก ํ•ด์•ผํ•  ์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋ณ‘๋ฆฌ๊ณผ ๊ต์ˆ˜๋‹˜ ํ™•์ธ ๊ฒฐ๊ณผ ์–‘์„ฑ(benign)์ด ๋งž๋‹ค๋ฉด ์›๋ฐœ๋ถ€์œ„ C75.5 M8680/0 ์œผ๋กœ ์•”๋“ฑ๋ก ํ•ฉ๋‹ˆ๋‹ค. ๋˜ํ•œ [bigo]๋ž€์— ํ•ด๋‹น ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์™€ ๋ณ‘๋ฆฌ์˜์‚ฌ benignํ™•์ธํ–ˆ๋‹ค๋Š” ๋‚ด์šฉ์„ ๊ธฐ์žฌ๋ฐ”๋ž๋‹ˆ๋‹ค.[์•”๋“ฑ๋ก์ง€์นจ์„œ p.41 ๊ทœ์น™F ํ–‰ํƒœํ•™์ฝ”๋“œ] ์ฐธ์กฐ.
. ์•„๋ž˜ TURB ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ์— ๋Œ€ํ•œ Morphology ์ฝ”๋“œ๋ฅผ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.Urinary bladder, transurethral resection :Lymphoepithelioma-like urothelial carcinoma, high grade(WHO grage:3/3)with 1) proper muscle invasion 2) lymphovascular invasion : not identifiedQ. M8082/3 (Lymphoepithelioma-like carcinoma)๋ฅผ ๋ถ€์—ฌํ•˜๋Š”์ง€, ๋˜๋Š” ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ์ฃผ์š” ๊ทœ์น™J, [๋ณต์žกํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…] "โ‘ฃ๋ฒˆ ์ฝ”๋“œ๋ฒˆํ˜ธ๊ฐ€ ๋†’์€ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์œผ๋กœ ์ฝ”๋“œํ•œ๋‹ค" ์— ๋”ฐ๋ผ M8120/3 (Urothelial carcinoma) ๋กœ ๋ถ€์—ฌํ•ด์•ผ ํ• ๊นŒ์š”?
ํ•ด๋‹น ์ •๋ณด๋งŒ์œผ๋กœ๋Š” M8120/3(Urothelial carcinoma) ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค. (๋ณต์žกํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ๊ทœ์น™ 4.๋†’์€์ฝ”๋“œ๋ฒˆํ˜ธ)[2012 ์•”๋“ฑ๋ก์ง€์นจ P.44 ๋ณต์žกํ•ฉ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…] ๊ทœ์น™1. ์กฐํ•ฉ์ฝ”๋“œ - 2. ์ƒ์„ธ์ฝ”๋“œ - 3. ๋น„์ค‘(%) - 4. ๋†’์€ ์ฝ”๋“œ๋ฒˆํ˜ธ
Schwannoma(์‹ ๊ฒฝ์ดˆ์ข…) ์›๋ฐœ๋ถ€์œ„ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.Bx]Brain, cerebellopontine angle, craniotomy and removal: Schwannoma, with 1) mitosis : 0/10 HPFs.MR Brain]1. Heterogeneously enhancing extra-axial mass along the right CP angle and right IAC (3.9x2.7x4.0cm). - hemorrhagic and cystic portion. - abutting to right CN 5. -- Vestibular schwannoma, likely.์ฃผ์น˜์˜๋Š” Rt CPA, vestibular schwannoma, 35mm ์ง„๋‹จ ๋‚ด๋ ธ์Šต๋‹ˆ๋‹ค. ์ด๋•Œ, ์›๋ฐœ ๋ถ€์œ„๋ฅผ C716(cerebellopontine angle) vs C724(Acoustic nerve) ๋‘˜ ์ค‘ ์–ด๋–ค ๊ฒƒ์„ ์ค˜์•ผ ํ• ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.โ€ป vestibular schwannoma(์ฒญ์‹ ๊ฒฝ์ดˆ์ข…)์€ ์ฒญ์‹ ๊ฒฝ์˜ ์Šˆ๋ฐ˜ ์„ธํฌ์—์„œ ๊ธฐ์›ํ•˜๋Š” ๋‡Œ์ข…์–‘์ž„์„ ์ฐธ๊ณ ํ•˜์˜€์Šต๋‹ˆ๋‹ค.
C724(acoustic nerve), M9560/0(Schwannoma, NOS)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
๋‡Œ์˜ ์ง€๋ฐฉ์ข… ์•”๋“ฑ๋ก ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. MRI ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์œผ๋ฉฐ, ์˜๋ฃŒ์ง„์€ ํ–‰๋™์–‘์‹๋ถˆ๋ช…์˜ ๋‡Œ์ข…์–‘๋ณด๊ณ  ์‚ฐ์ •ํŠน๋ก€๋“ฑ๋ก ํ•˜์˜€์Šต๋‹ˆ๋‹ค. .. 1. A T1 hyperintense extra-axial lesion in the right ambient cistern (1 cm in Dmax.). - dark signal intensity on fat suppressed FLAIR. - T2 hyperintensity. --> Ambient cistern lipoma, most likely. [ Conclusion ]1. A T1 hyperintense extra-axial lesion in the right ambient cistern (1 cm in Dmax.). --> Ambient cistern lipoma, most likely. 2. Negative in intracranial MRA, except normal variations.๋ชฐํด๋กœ์ง€ ์ฝ”๋“œ๋ฅผ ์–ด๋–ป๊ฒŒ ๋ถ€์—ฌ ํ•ด์•ผํ• ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
'ICD-O-3 ์— ๋”ฐ๋ผ M8850/0(Lipoma, NOS)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค. ๋˜ํ•œ [bigo]๋ž€์— ๊ฒ€์‚ฌ๊ฒฐ๊ณผ ๋‚ด์šฉ ๊ธฐ์žฌ๋ฐ”๋ž๋‹ˆ๋‹ค.(์›๋ฐœ๋ถ€์œ„์™€ ์กฐ์งํ•™์  ์†Œ๊ฒฌ)